text: Tesco Corporation Company Profile (NASDAQ:TESO) Company Profile Analyst Ratings Earnings History Earnings Estimates Dividend History Insider Trade Headlines Social Media Chart About Tesco Corporation (NASDAQ:TESO) Tesco Corporation is a provider of technology-based solutions for drilling, servicing and completion of wells for the upstream energy industry. The Company's operations consist of top drives and automated pipe handling equipment sales and rentals; aftermarket sales and services, and tubular services, including related products and accessories sales. Its segments include Products, Tubular Services, Research and Engineering, and Corporate and Other. The Products segment includes top drives and automated pipe handling equipment sales, rentals and aftermarket sales and services. The Tubular Services segment includes onshore and offshore tubular services and sales of related products and accessories. The Research and Engineering segment includes internal research, engineering, and development activities related to its products and tubular services. The Corporate and Other segment includes executive management and various global support and compliance functions. Industry, Sector and Symbol: Sector: Oils/Energy Industry: Oil Related Equipment Sub-Industry: Oil & Gas Equipment & Services Symbol: NASDAQ:TESO CUSIP: 88157K10 Web: www.tescocorp.com Capitalization:Market Cap: $229.09 millionOutstanding Shares: 46,754,000Average Prices:50 Day Moving Avg: $4.99200 Day Moving Avg: $5.1052 Week Range: $3.70 - $9.65 P/E:Trailing P/E Ratio: N/AForeward P/E Ratio: -9.07P/E Growth: -0.09Sales & Book Value:Annual Revenue: $142.59 millionPrice / Sales: 1.61Book Value: $6.13 per sharePrice / Book: 0.80 Profitability:EBITDA: ($34,720,000.00)Net Margins: -47.72%Return on Equity: -18.21%Return on Assets: -16.32%Debt:Current Ratio: 5.86%Quick Ratio: 3.78%Misc:Average Volume: 656,212 shs.Beta: 1.28Short Ratio: 10.82 Frequently Asked Questions for Tesco Corporation (NASDAQ:TESO) What is Tesco Corporation's stock symbol? Tesco Corporation trades on the NASDAQ under the ticker symbol "TESO." How were Tesco Corporation's earnings last quarter? Tesco Corporation (NASDAQ:TESO) released its quarterly earnings results on Tuesday, August, 8th. The company reported ($0.25) earnings per share for the quarter, missing the Zacks' consensus estimate of ($0.24) by $0.01. The company earned $40.10 million during the quarter, compared to analyst estimates of $41.01 million. Tesco Corporation had a negative net margin of 47.72% and a negative return on equity of 18.21%. The company's revenue for the quarter was up 19.3% compared to the same quarter last year. During the same quarter last year, the business earned ($0.39) EPS. View Tesco Corporation's Earnings History. When will Tesco Corporation make its next earnings announcement? Tesco Corporation is scheduled to release their next quarterly earnings announcement on Friday, November, 3rd 2017. View Earnings Estimates for Tesco Corporation. Where is Tesco Corporation's stock going? Where will Tesco Corporation's stock price be in 2017? 5 analysts have issued 12 month price targets for Tesco Corporation's stock. Their predictions range from $5.00 to $7.00. On average, they expect Tesco Corporation's stock price to reach $6.00 in the next year. View Analyst Ratings for Tesco Corporation. Who are some of Tesco Corporation's key competitors? Some companies that are related to Tesco Corporation include Denbury Resources (DNR), California Resources Corporation (CRC), Renewable Energy Group (REGI), Vivint Solar (VSLR), W&T Offshore (WTI), Azure Power Global (AZRE), San Juan Basin Royalty Trust (SJT), Matrix Service Company (MTRX), Natural Gas Services Group (NGS), CNX Coal Resources LP (CNXC), Sanchez Energy Corporation (SN), Abraxas Petroleum Corporation (AXAS), Bill Barrett Corporation (BBG), Arc Logistic Partners LP (ARCX), Cloud Peak Energy (CLD), Natural Resource Partners LP (NRP), Tetra Technologies (TTI) and Energy XXI Gulf Coast (EXXI). Who are Tesco Corporation's key executives? Tesco Corporation's management team includes the folowing people: Michael W. Sutherlin, Independent Chairman of the BoardFernando Rafael Assing, President, Chief Executive Officer, DirectorChristopher L. Boone, Chief Financial Officer, Senior Vice PresidentJohn Terrell Gatlin, Chief Operating Officer, Senior Vice PresidentDarko Ulakovic, Vice President - Products Manufacturing, General Manager - TESCO Manufacturing FacilityDouglas R. Ramsay, DirectorJohn P. Dielwart, Independent DirectorFrederick J. Dyment CPA, Independent DirectorGary L. Kott, Independent DirectorRaymond Vance Milligan, Independent Director How do I buy Tesco Corporation stock? Shares of Tesco Corporation can be purchased through any online brokerage account. Popular online brokerages include Vanguard Brokerage Services, TD Ameritrade, E*TRADE, Scottrade, Fidelity and Charles Schwab. What is Tesco Corporation's stock price today? One share of Tesco Corporation stock can currently be purchased for approximately $4.90. MarketBeat Community Rating for Tesco Corporation (NASDAQ TESO)Community Ranking: 2.4 out of 5 ( )Outperform Votes: 163 (Vote Outperform)Underperform Votes: 182 (Vote Underperform)Total Votes: 345MarketBeat's community ratings are surveys of what our community members think about Tesco Corporation and other stocks. Vote "Outperform" if you believe the stock will outperform the S&P 500 over the long term. Vote "Underperform" if you believe the stock will underperform the S&P 500 over the long term. You may vote once every thirty days. Analyst Ratings Consensus Ratings for Tesco Corporation (NASDAQ:TESO) (How are Consensus Ratings Calculated?) MarketBeat calculates consensus ratings using the most recent rating from each brokerage that has rated a stock within the last twelve months. Since brokers often use different ratings systems, each rating is normalized to a standardized rating score of 1 (sell), 2 (hold), 3 (buy) or 4 (strong buy). Consensus ratings scores are calculated using the mean average of the number of normalized sell, hold, buy and strong buy ratings. Each stock's consensus rating is derived from its calculated consensus ratings score (0-1.5 = Sell, 1.5-2.5 = Hold, 2.5-3.5 = Buy, >3.5 = Strong Buy). MarketBeat's consensus price targets are a mean average of the most recent available price targets set by each analyst that has set a price target for the stock in the last twelve months.MarketBeat will no longer include ratings and price target data in its consensus calculation if a broker drops coverage and MarketBeat has received a report that coverage was dropped. Ratings from certain research firms that issue ratings using purely quantitative methods (such as Zacks, Vetr and ValuEngine) are not included in consensus calculations. MarketBeat's consensus ratings and consensus price targets may differ from those calculated by other firms due to differences in methodology and available data.Ratings Breakdown: 1 Sell Rating, 2 Hold Ratings, 2 Buy RatingsConsensus Rating:Hold (Score: 2.20)Consensus Price Target: $6.00 (22.45% upside)Consensus Price Target History for Tesco Corporation (NASDAQ:TESO) Analysts' Ratings History for Tesco Corporation (NASDAQ:TESO) Show: Only the Most Recent Rating From Each Brokerage All Ratings For This Stock DateFirmActionRatingPrice TargetImpact on Share PriceDetails10/6/2017Cowen and CompanySet Price TargetHold$5.00N/A8/16/2017FBR & CoSet Price TargetBuy$9.00 -> $7.00High8/9/2017Seaport Global SecuritiesReiterated RatingNeutralMedium12/22/2016Bank of America CorporationInitiated CoverageUnderperformN/A11/17/2016HSBC Holdings plcUpgradeBuyN/A9/26/2016Barclays PLCReiterated RatingBuyN/A3/2/2016Iberia CapitalLower Price TargetSector Perform$9.00 -> $8.00N/A12/1/2015GuggenheimUpgradeNeutral -> BuyN/A(Data available from 10/17/2015 forward) Earnings Earnings History for Tesco Corporation (NASDAQ:TESO)Earnings History by Quarter for Tesco Corporation (NASDAQ TESO)DateQuarterConsensus EstimateActual EPSRevenue EstimateActual RevenueRelease LinkConference CallDetails11/2/2017Q3 2017($0.22)N/A8/8/2017Q2 2017($0.24)($0.25)$41.01 million$40.10 millionViewListen5/9/2017Q1 2017($0.29)($0.29)$35.65 million$36.70 millionViewListen2/28/2017Q416($0.35)($0.28)$30.99 million$35.30 millionViewListen11/4/2016Q316($0.37)($0.37)$29.20 million$30.40 millionViewListen8/9/2016Q216($0.42)($0.39)$32.41 million$33.60 millionViewListen5/10/2016Q116($0.35)($0.46)$42.86 million$35.50 millionViewListen3/1/2016Q415($0.32)($0.33)$56.37 million$52.20 millionViewListen11/4/2015Q315($0.25)($0.32)$65.60 million$61.40 millionViewListen8/6/2015Q215($0.07)($0.21)$75.94 million$74.50 millionViewListen5/8/2015Q115($0.01)($0.08)$99.34 million$91.70 millionViewN/A3/31/2015$0.14$0.12$127.72 million$134.50 millionViewN/A11/4/2014Q314$0.34$0.27$154.08 million$141.90 millionViewN/A8/1/2014Q214$0.28$0.29$143.08 million$145.10 millionViewN/A5/5/2014Q114$0.25$0.21$137.52 million$121.40 millionViewN/A2/28/2014Q413$0.30$0.14$133.10 millionViewN/A11/4/2013Q313$0.24$0.29$133.08 million$132.20 millionViewN/A8/6/2013Q2 2013$0.19$0.26$129.10 million$129.00 millionViewListen5/6/2013Q1 2013$0.25$0.22$126.22 million$127.10 millionViewListen2/28/2013Q4 2012$0.21$0.34$120.47 million$137.60 millionViewListen11/5/2012Q312$0.26$0.23$127.77 million$126.40 millionViewN/A8/6/2012$0.33$0.34ViewN/A11/7/2011$0.23$0.10ViewN/A(Data available from 1/1/2011 forward) Estimates Earnings Estimates for Tesco Corporation (NASDAQ:TESO)2017 EPS Consensus Estimate: ($0.93)2018 EPS Consensus Estimate: ($0.53)QuarterNumber of EstimatesLow EstimateHigh EstimateAverage EstimateQ1 20173($0.31)($0.28)($0.30)Q2 20173($0.26)($0.23)($0.24)Q3 20173($0.23)($0.20)($0.22)Q4 20173($0.23)($0.14)($0.18)Q1 20183($0.20)($0.12)($0.16)Q2 20183($0.19)($0.07)($0.14)Q3 20183($0.17)($0.04)($0.12)Q4 20183($0.17)($0.02)($0.11)Q1 20191($0.13)($0.13)($0.13)Q2 20191($0.10)($0.10)($0.10)(Data provided by Zacks Investment Research) Dividends Dividend History by Quarter for Tesco Corporation (NASDAQ TESO)AnnouncedPeriodAmountYieldEx-Dividend DateRecord DatePayable Date11/3/2015quarterly$0.052.31%11/10/201511/13/201512/4/20158/4/2015quarterly$0.052.16%8/12/20158/14/20158/28/20155/13/2015quarterly$0.051.63%5/27/20155/29/20156/15/20153/2/2015quarterly$0.051.9%3/20/20153/24/20154/6/201511/13/2014quarterly$0.051.26%11/20/201411/24/201412/4/20148/8/2014quarterly$0.051.04%8/20/20148/22/20149/2/20145/5/2014special$0.055/20/20145/22/20146/2/2014(Data available from 1/1/2013 forward) Insider Trades Insider Trading and Institutional Ownership History for Tesco Corporation (NASDAQ:TESO)Insider Ownership Percentage: 1.70%Institutional Ownership Percentage: 91.12%Insider Trades by Quarter for Tesco Corporation (NASDAQ:TESO)Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionDetails6/14/2017Thomas B Sloan JrVPSell170$4.70$799.00 3/7/2017Fred J DymentDirectorSell20,000$8.76$175,200.00 1/4/2017Fernando Rafael AssingCEOSell2,857$8.55$24,427.35 1/3/2017Christopher L BooneCFOSell3,529$8.25$29,114.25 1/3/2017Fernando Rafael AssingCEOSell5,214$8.25$43,015.50 1/3/2017Nicholas MawfordVPSell757$8.25$6,245.25 12/21/2016Fernando Rafael AssingCEOSell4,224$9.03$38,142.72 12/13/2016Christopher L BooneCFOSell1,106$8.80$9,732.80 12/13/2016Douglas GreeningVPSell494$8.80$4,347.20 12/13/2016Fernando Rafael AssingCEOSell11,533$8.80$101,490.40 12/13/2016John DielwartDirectorSell1,090$8.80$9,592.00 12/8/2016Fernando Rafael AssingCEOSell30,444$8.44$256,947.36 12/7/2016John DielwartDirectorSell1,374$8.60$11,816.40 12/6/2016Christopher L BooneCFOSell2,751$8.16$22,448.16 12/6/2016Michael IrausquinVPSell696$8.16$5,679.36 12/6/2016Thomas B SloanInsiderSell1,892$8.16$15,438.7212/4/2016Michael W SutherlinDirectorBuy5,500$7.73$42,515.0012/4/2016Thomas B SloanInsiderBuy7,333$7.73$56,684.0911/17/2016Michael IrausquinVPSell4,098$7.05$28,890.90 11/11/2016Fernando Rafael AssingCEOSell3,333$7.15$23,830.95 11/11/2016Gary L KottDirectorSell15,432$7.06$108,949.92 11/11/2016Nicholas MawfordVPSell191$7.06$1,348.46 3/8/2016Michael James NiedermaierInsiderSell1,102$11.42$12,584.841/6/2016Christopher L BooneCFOSell866$7.09$6,139.94 1/6/2016Fernando Rafael AssingDirectorSell6,318$7.10$44,847.691/6/2016Mihial Dean FerrisSVPSell3,679$7.09$26,084.11 1/6/2016Roy Evan McnivenInsiderSell398$7.11$2,828.271/5/2016Douglas GreeningVPSell229$7.36$1,685.44 1/5/2016Nicholas MawfordInsiderSell1,245$7.36$9,158.7212/31/2015Roy Evan McnivenInsiderBuy1,395$0.00$0.0012/30/2015Douglas Christian GreeningInsiderSell345$7.27$2,508.0112/23/2015Fernando Rafael AssingDirectorSell2,368$7.55$17,889.0612/23/2015Roy Evan McnivenInsiderSell312$7.56$2,359.4712/19/2015Fernando Rafael AssingDirectorBuy6,667$0.00$0.0012/18/2015Christopher L BooneCFOSell1,087$7.09$7,706.83 12/18/2015Darko UlakovicInsiderSell458$7.09$3,245.5312/18/2015Fernando Rafael AssingDirectorSell6,913$7.08$48,972.3812/18/2015Michael IrausquinVPSell334$7.09$2,368.06 12/18/2015Mihial Dean FerrisSVPSell765$7.11$5,439.15 11/18/2015R. Vance MilliganDirectorBuy11,500$7.82$89,892.055/10/2015Michael W SutherlinDirectorBuy1,167$0.00$0.005/10/2015Mihial Dean FerrisInsiderBuy2,168$0.00$0.001/5/2015Fernando Rafael AssingCEOSell5,329$12.35$65,813.15 1/5/2015Julio M QuintanaDirectorSell21,507$12.12$260,664.84 1/5/2015Mihial Dean FerrisSVPSell2,812$12.21$34,334.52 12/12/2014Mihial Dean FerrisSVPSell3,000$12.29$36,870.00 9/12/2014Mihial Dean FerrisSVPSell1,671$20.09$33,570.39 8/12/2014Fernando Rafael AssingCOOSell1,753$19.76$34,639.28 6/9/2014V Luxembourg Holdings S.A LrpMajor ShareholderSell1,066,182$21.25$22,656,367.50 5/20/2014Julio QuintanaCEOSell4,562$21.05$96,030.10 5/12/2014Gary KottDirectorSell9,633$21.54$207,494.82 5/12/2014Mihial Dean FerrisSVPSell4,400$21.48$94,512.00 4/7/2014Fernando Rafael AssingCOOSell29,591$17.93$530,566.63 3/13/2014Julio QuintanaCEOSell12,252$17.00$208,284.00 3/12/2014Julio QuintanaCEOSell67,741$17.01$1,152,274.41 3/11/2014Julio QuintanaCEOSell101,237$17.19$1,740,264.03 12/13/2013Mihial Dean FerrisSVPSell41,533$18.26$758,392.58 12/12/2013Mihial Dean FerrisSVPSell4,667$18.21$84,986.07 12/11/2013Jeffrey FosterVPSell2,491$18.01$44,862.91 11/13/2013Fernando Rafael AssingCOOSell2,923$18.65$54,513.95 11/13/2013Julio QuintanaCEOSell11,065$18.63$206,140.95 8/13/2013Fernando Rafael AssingCOOSell1,240$14.95$18,538.00 8/13/2013Mihial Dean FerrisSVPSell1,664$14.97$24,910.08 5/15/2013Julio Manuel QuintanaDirectorSell4,036$12.48$50,367.67 11/14/2012Julio M QuintanaCEOSell6,637$10.00$66,370.00 8/10/2012Mihial Dean FerrisSVPSell2,900$11.28$32,712.00 (Data available from 1/1/2013 forward) Headlines Headline Trends for Tesco Corporation (NASDAQ:TESO) Latest Headlines for Tesco Corporation (NASDAQ:TESO) Source: All Sources Trusted Sources MarketBeat.com Bloomberg MarketWatch Motley Fool NASDAQ Reuters Seeking Alpha The Street The Wall Street Journal Yahoo Finance DateHeadlineTesco whistleblower did not raise concerns in appraisal, court toldfinance.yahoo.com - October 11 at 8:54 PMCity of London plans new court to handle cyber and fraud caseswww.ft.com - October 11 at 3:48 PMTESO Crosses Above Average Analyst Targetwww.thestreet.com - October 11 at 3:48 PMTesco's UK forecasts changing overnight in 2014, court toldfinance.yahoo.com - October 11 at 8:30 AMZacks: Analysts Anticipate Tesco Corporation (TESO) Will Post Quarterly Sales of $43.67 Millionwww.americanbankingnews.com - October 10 at 11:00 AMZacks: Brokerages Anticipate Tesco Corporation (TESO) Will Announce Earnings of -$0.21 Per Sharewww.americanbankingnews.com - October 8 at 6:26 AMTesco Corporation (TESO) Receives Consensus Rating of "Hold" from Brokerageswww.americanbankingnews.com - October 7 at 6:52 AMTesco Corporation (TESO) Receives Hold Rating from Cowen and Companywww.americanbankingnews.com - October 6 at 5:30 PMTesco whistleblower tells of mounting anxieties over accounts gapfinance.yahoo.com - October 6 at 11:12 AMTesco finance team "falling apart" in 2014, court toldfinance.yahoo.com - October 6 at 11:12 AMTesco's UK boss told "word by word" of hole in accounts, court hearsfinance.yahoo.com - October 6 at 11:12 AMTesco CEO: Ex-Sainsbury boss is wrong on Brexit — but 'no deal' could push up food priceswww.businessinsider.com - October 5 at 4:52 AMTwo Tesco finance staff quit over accounting concerns, court toldfinance.yahoo.com - October 3 at 6:29 PMFormer Tesco executives pressured staff 'to cook books', court toldfinance.yahoo.com - October 3 at 1:27 PMBroadbent to give evidence in trial of former Tesco executivesfinance.yahoo.com - October 3 at 1:27 PMEx-Tesco executives 'connived and manipulated figures' to cover up £250 million accounting black hole, court toldwww.businessinsider.com - October 3 at 5:02 AMFrank's International (FI) Names Michael Kearney as President and CEO; CEO Douglas G. Stephens Departswww.streetinsider.com - September 28 at 5:17 AMFrank's International CEO departs after less than a yearwww.bizjournals.com - September 28 at 5:17 AMSandell Asset Management Europe Limited: Form 8.3 - Tesco PLC - AMENDMENTwww.finanznachrichten.de - September 23 at 9:58 AM Brokerages Expect Tesco Corporation (TESO) Will Announce Quarterly Sales of $43.87 Millionwww.americanbankingnews.com - September 21 at 5:36 AMETFs with exposure to Tesco Corp. : September 15, 2017finance.yahoo.com - September 16 at 9:23 AMTesco Corporation (TESO) Given Consensus Recommendation of "Hold" by Brokerageswww.americanbankingnews.com - September 12 at 6:56 AMTesco Corporation (TESO) Expected to Post Quarterly Sales of $43.87 Millionwww.americanbankingnews.com - September 2 at 3:50 AMETFs with exposure to Tesco Corp. : September 1, 2017finance.yahoo.com - September 1 at 9:41 AMSHAREHOLDER ALERT: Monteverde & Associates PC Announces An Investigation Of Tesco Corporation - TESOfinance.yahoo.com - September 1 at 9:41 AMTesco Corp. :TESO-US: Earnings Analysis: Q2, 2017 By the Numbers : August 25, 2017finance.yahoo.com - August 26 at 9:18 AMCorrelation between Nabors Industries and Crude Oil on August 18finance.yahoo.com - August 23 at 12:26 PMTesco Corporation (TESO) Given a $7.00 Price Target by FBR & Co Analystswww.americanbankingnews.com - August 20 at 10:12 PMWhy I'd buy this bargain dividend stock instead of Tesco plcwww.fool.co.uk - August 16 at 8:05 AMTESCO CORPORATION SHAREHOLDER ALERT: Rigrodsky & Long, P.A. Announces Investigation of Buyoutfinance.yahoo.com - August 16 at 8:04 AMCorporate News Blog - TESCO Enters into a Stock-for-Stock Combination Agreement with Nabors Industriesfinance.yahoo.com - August 16 at 8:04 AMQ3 2017 Earnings Estimate for Tesco Co. Issued By Capital One Financial Corporation (TESO)www.americanbankingnews.com - August 16 at 6:26 AMNabors To Acquire Tesco Corp. For $4.62/share In All-Stock Deal - Quick Factswww.rttnews.com - August 15 at 7:36 AMNabors Industries to buy Tesco in all-stock dealseekingalpha.com - August 14 at 9:28 AMNabors Announces Agreement to Acquire Tesco Corporation in an All-Stock Transactionfinance.yahoo.com - August 14 at 6:14 AMTESCO Corporation Enters into Arrangement Agreement with Nabors Industries Ltd. in Stock-for-Stock Combinationfinance.yahoo.com - August 14 at 6:14 AMSeaport Global Securities Reiterates Neutral Rating for Tesco Corporation (TESO)www.americanbankingnews.com - August 11 at 4:00 PMBrokers Issue Forecasts for Tesco Corporation's Q3 2017 Earnings (NASDAQ:TESO)www.americanbankingnews.com - August 11 at 11:40 AMTesco's (TESO) CEO Fernando Assing on Q2 2017 Results - Earnings Call Transcriptseekingalpha.com - August 10 at 8:38 AMHow Many Companies Does Tesco Own?www.investopedia.com - August 10 at 8:38 AMEdited Transcript of TESO earnings conference call or presentation 8-Aug-17 2:00pm GMTfinance.yahoo.com - August 9 at 8:06 AMTesco Corporation (TESO) Issues Earnings Resultswww.americanbankingnews.com - August 8 at 9:42 AMBRIEF-Tesco reports Q2 adjusted loss per share $0.25 excluding itemswww.reuters.com - August 8 at 7:25 AMTesco reports 2Q losswww.cnbc.com - August 8 at 7:25 AMHead to Head Survey: Tesco Corporation (NASDAQ:TESO) versus Natural Gas Services Group (NGS)www.americanbankingnews.com - August 7 at 10:08 PMWhy Amazon Will Not Kill This Businessfinance.yahoo.com - August 4 at 8:59 AMTesco Corporation (TESO) Set to Announce Quarterly Earnings on Tuesdaywww.americanbankingnews.com - August 1 at 7:31 AMComparing Tesco Corporation (NASDAQ:TESO) & CIRCOR International (CIR)www.americanbankingnews.com - July 31 at 9:33 AM$40.65 Million in Sales Expected for Tesco Corporation (NASDAQ:TESO) This Quarterwww.americanbankingnews.com - July 28 at 5:25 PMHead-To-Head Review: Tesco Corporation (TESO) & Dresser-Rand Group (DRC)www.americanbankingnews.com - July 27 at 9:10 AM Social Chart Tesco Corporation (TESO) Chart for Tuesday, October, 17, 2017 This page was last updated on 10/17/2017 by MarketBeat.com Staff


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Conceived and designed the experiments: SM EM. Performed the experiments: SCS EM LKH MV-G. Analyzed the data: SCS SM EM LKH. Contributed reagents/materials/analysis tools: EM PB JDA LKH. Wrote the paper: SCS SM EM.
The authors have declared that no competing interests exist.
Heparanase is an enzyme involved in extracellular matrix remodelling and heparan sulphate proteoglycan catabolism. It is secreted by metastatic tumour cells, allowing them to penetrate the endothelial cell layer and basement membrane to invade target organs. The release of growth factors at the site of cleaved heparan sulphate chains further enhance the potential of the tumour by encouraging the process of angiogenesis. This leads to increased survival and further proliferation of the tumour. Aptamers are single or double stranded oligonucleotides that recognise specific small molecules, peptides, proteins, or even cells or tissues and have shown great potential over the years as diagnostic and therapeutic agents in anticancer treatment. For the first time, single stranded DNA aptamers were successfully generated against the active heterodimer form of heparanase using a modified SELEX protocol, and eluted based on increasing affinity for the target. Sandwich ELISA assays showed recognition of heparanase by the aptamers at a site distinct from that of a polyclonal HPSE1 antibody. The binding affinities of aptamer to immobilised enzyme were high (7×107 to 8×107 M−1) as measured by fluorescence spectroscopy. Immunohistochemistry and immunofluorescence studies demonstrated that the aptamers were able to recognise heparanase with staining comparable or in some cases superior to that of the HPSE1 antibody control. Finally, matrigel assay demonstrated that aptamers were able to inhibit heparanase. This study provides clear proof of principle concept that nucleic acid aptamers can be generated against heparanase. These reagents may serve as useful tools to explore the functional role of the enzyme and in the future development of diagnostic assays or therapeutic reagents.
Heparanase is a β-1,4-endoglycosidase enzyme
Upon secretion of heparanase from metastatic tumour cells, the enzyme hydrolyses the glycosidic bonds of heparan sulphate chains attached to proteoglycans to products 10–20 sugar units in length
Aptamers are short DNA or RNA oligonucleotides developed for diagnostic and therapeutic use that display high binding affinity and specificity for target molecules
In this study, aptamers displaying high affinity and specificity were generated against the active enzyme heparanase using a modified SELEX procedure. Their binding to heparanase was characterised using ELISAs, quartz crystal microbalance (QCM) and fluorescence quenching experiments and aptamers were found to interact with the enzyme with equilibrium association constants in the range of 107 M−1 and could detect heparanase at 10 nM in buffer. Aptamers bound to the enzyme at a site different to that recognised by the antibody used as a control, but in cell and tissue labelling studies they demonstrated comparable and in one instance superior recognition and staining, as well as the ability to inhibit heparanase action in matrigel assays. Thus, aptamers have shown the ability to specifically recognise purified heparanase as well as heparanase expressed in cells and tissue, offering the potential for further therapeutic and diagnostic development.
Aptamers were selected against heparanase using a modified single-round SELEX protocol. Briefly, the aptamer library was incubated with heparanase in a Top Yield PCR tube for one hour at room temperature and eluted using a salt step gradient. Eluates were desalted using Microcon filters and amplified by PCR. Aptamers were detected by agarose gel electrophoresis (
Bands at 75bp were observed in all fractions except the negative control, suggesting that different species of aptamer had bound with different affinities, removed in each salt concentration.
|1.5 M NaCl selection
|3.0 M NaSCN selection
The homologous aptamer sequences from both 1.5 M NaCl and 3.0 M NaSCN elutions were analysed using the Mfold
Competition ELISAs determined that a heparanase polyclonal antibody and the selected aptamers do not compete for the same binding site (data not shown) as there was no reduction in signal from the polyclonal antibody upon aptamer addition. Therefore, their binding was investigated by a sandwich ELISA, where both antibody and aptamer were utilised (
Schematic diagram (right) of the ELISA.
Aptamers were subsequently used to capture and bind heparanase from solution (100–800 nM) in QCM experiments.
Higher concentrations of heparanase exhibited a greater decrease in frequency. Binding and regeneration sensogram (b) for addition of 800 nM heparanase to a quartz crystal immobilised with 1.5 M short aptamer. After a PBS wash, a Δfr of 37.46 Hz was observed, confirming heparanase was retained and bound. Washing with EDTA and 3.0 M NaSCN allowed almost total regeneration of the crystal.
Fluorescence quenching titrations were carried out using the natural intrinsic fluorescence of heparanase (due to the solvatochromic emission peak of tryptophan) to determine the binding interactions of the three aptamers, analysed by a quadratic equation
To test for recognition and specificity of the aptamers in comparison with the heparanase polyclonal antibody, paraffin-embedded placental tissue was sectioned and subjected to immunohistochemistry (
Nuclei were stained blue.
In first trimester placenta stained with polyclonal anti-heparanase antibody, staining was seen in the nuclei and cytoplasm of the cytotrophoblast-syncytiotrophoblast bilayer lining the intervillous space of the chorionic villi, and in endothelial cells of the developing blood vessels. No staining was observed when a mouse antibody was used as a negative control. Of the aptamers, 1.5 M short stained the cytoplasm of the outer syncytiotrophoblasts and 1.5 M long exhibited a staining pattern almost identical, although less intense than the antibody. 3.0 M did show staining, although more uniformly throughout the stroma and not in the same pattern as the antibody, which suggests non-specific staining.
In term placenta, heparanase antibody staining remains localised to syncytiotrophoblasts, and blood vessels. The negative control is unstained. 1.5 M long aptamer shows an identical staining pattern and intensity to the heparanase antibody. 1.5 M short stains fetal capillaries and 3.0 M shows a low level of stromal staining, which suggests once again non-specific binding.
PL4, a first trimester immortalised trophoblast cell line, when fluorescently labelled with the anti-heparanase antibody (
The Matrigel invasion assay was performed to investigate whether binding of aptamers to heparanase inhibited the enzyme's function of hydrolysing heparan sulphate proteoglycans (
The negative controls were represented as no inhibitor and a control mouse antibody. Figures are representative of the average of triplicate experiments and error bars show standard deviation of the mean.
Aptamers were successfully selected against the active heterodimer form of heparanase using an optimised, modified SELEX protocol based on interruption of the interactions formed between protein and aptamer by high salt content. Aptamers generated from 1.5 M NaCl and 3.0 M NaSCN elutions each suggested one prominent species based on sequence homology. Based on their predicted structures using Mfold structure predicting software, the aptamers were truncated to remove any nucleotides not implicated in structure formation for downstream considerations, such as cost and improved tissue penetration, before carrying out preliminary binding experiments. The binding data obtained from ELISA, QCM and fluorescence quenching titrations confirmed that the aptamers bind heparanase with high affinity, possibly close to two of its six tryptophan residues, but at a different site to that of the antibody, which is still able to bind heparanase simultaneously with the aptamers. Equilibrium dissociation constants for the aptamers generated to heparanase were calculated as 13.7 nM, 12 nM and 13 nM for 1.5 M short, long and 3.0 M respectively, which compares with high affinity aptamers generated by other groups for their targets
Aptamer library (5′–GGGAGACAAGAATAAACGCTCAA-25N-TTCGACAGGAGGCTCACAACAGGC-3′) (University of Nottingham, UK) was firstly amplified exponentially with 10 µM forward (
187 nM 5′ biotinylated aptamers (Eurofins; Ebersberg, Germany) were immobilised to the wells of a Maxisorp ELISA plate (NUNC supplied by Fisher Scientific, Loughborough, UK) via 2.5 µg/ml NeutrAvidin® (Invitrogen, Paisley, UK) in PBS (10 mM phosphate buffer, 2.7 mM potassium chloride and 137 mM sodium chloride, pH 7.4, Sigma Aldrich Ltd, Gillingham, UK) overnight at 4°C. After the plate was washed three times with wash buffer (5% Tween 20 in PBS), sample wells were blocked with 10 mg/ml BSA (Sigma Aldrich Ltd, Gillingham, UK) in PBS for 20 minutes at room temperature. After three washes in wash buffer, heparanase was added to sample wells in series between 0 and 200 nM in assay diluent (0.1% Tween 20, 72 mM BSA in PBS), and incubated for one hour at room temperature. After a further three washes in wash buffer, polyclonal rabbit anti-heparanase IgG (kindly supplied by Professor Paul Brenchley, University of Manchester, UK)
Experiments were carried out according to Liss et al
To measure the binding of heparanase to the aptamers immobilised on the gold surface, the crystal was placed in the flow cell which was connected to a pump. Samples were drawn through into the flow cell in a stop-flow manner. PBS was run through the system for one minute on fast flow, then the pump was halted, the program and monitoring switched on, the capacitance adjusted, and the crystal left to equilibrate in the PBS contained within the flow cell for one hour or until the reading was stabilised. After pausing the program and taking care not to introduce any air into the system, human recombinant polymorphic heparanase diluted in PBS was added to the flow cell, using the pump to pull the liquid through very slowly, then the pump was halted and the program was resumed. When the readings had stabilised, the program was paused and the crystal was washed using the pump to pull 10 ml PBS through the system, the pump was ceased and the readings resumed. After the readings had settled, the program was paused and the crystal was regenerated with 10 ml 100 mM EDTA, then 3.0 M NaSCN (both from Sigma Aldrich Ltd, Gillingham, UK) before the experiment ended. The crystal was kept at 4°C in a chamber of PBS containing 0.02% sodium azide until the next experiment. The results, displayed as Δfr (change in resonance frequency), are inversely related to the mass at the surface of the crystal (Δm) as explained in the Sauerbrey equation
Experiments were performed using a Horiba Jobin Yvon Fluoromax-P fluorimeter, with the sample in a 100 µl fluorescence cuvette. Emission spectra were acquired between 300 and 420 nm with an excitation wavelength of 280 nm and integration time of 1s, at 5 nm increments and at room temperature. After performing the acquisition on 250 nM heparanase in salt solution, aptamer was titrated to the following final concentrations in the cuvette, mixed and an acquisition taken immediately: 25 nM, 50 nM, 100 nM, 200 nM, 400 nM. Results were analysed using Microcal Origin 6 and the equilibrium association constant (KA) determined using the equation described by Missailidis and Brady
Immunohistochemistry, immunofluorescence and Matrigel invasion studies were carried out within the Maternal and Fetal Health Research Centre at The University of Manchester. All media and supplements were purchased from Invitrogen Ltd (Paisley, UK).
First trimester placental samples from women undergoing elective terminations of pregnancy between 8–12 weeks gestation and term placental samples were obtained from St. Mary's Hospital, Manchester. Written informed consent was obtained from all patients and ethical approval was obtained from Central Manchester Local Research Ethics Committee (03/CM/031).
Cell lines were cultured to 80% confluency for the following experiments and media were supplemented with 10% FBS, L-glutamine (2 mM), penicillin (100 IU/ml) and streptomycin (100 µg/ml). Placental stromal cells (first trimester) were cultured in 50% DMEM 50% Ham's F12 supplemented with 1% non-essential amino acids and first trimester transformed PL4 trophoblasts were cultured in Ham's F10 medium. Ovarian carcinoma cell line OC MZ-6 was cultured in DMEM containing 10 mM HEPES, 116 mg/L arginine and 36 mg/L asparagine.
Wax embedded samples of first trimester and term placenta were sectioned at 5 µm. Slides were warmed for 10 min at 60°C to soften the wax, then deparaffinised in xylene and alcohol, and rinsed in tap water. Slides were immersed in citrate buffer (2.94g sodium citrate in 1l of dH2O, pH 6.0, with 500 µl Tween 20) and microwaved at high temperature for a total of 10 min. After cooling, endogenous peroxide activity was blocked by placing slides in methanol containing 0.4% (v/v) HCl and 0.5% (v/v) H2O2 for 30 min. After rinsing in running water, the slides were washed for 5 min in TBS. Sections were blocked for 30 min with 5% BSA in TBS, and then primary antibody/5′ biotinylated aptamers were added in TBS (1∶100 dilutions for anti-heparanase and anti-cytokeratin 7, neat for control mouse antibody and 500 nM for all aptamers) and left overnight at 4°C in humidity chamber. After washing slides for 3×5 min in TBS, secondary antibodies were incubated at 1∶200 dilutions for 1h at room temperature to relevant sections and aptamer-labelled sections were incubated with TBS only. Slides were washed three times for 5 min each in TBS, and then avidin peroxidase was added to all sections at 5 µg/ml in TBS and incubated at room temperature for 1h, then washed off with TBS. 3,3′-Diaminobenzidine tetrahydrochloride (DAB) was used to develop the avidin peroxidase (280 ml TBS +20 ml DAB. 45 µl H2O2 was added before use). Slides were washed in tap water and counterstained with Meyers' haematoxylin for 5 min, then once more washed with tap water. Slides were dipped in acid alcohol solution to remove excess stain for five seconds and then immersed in tap water for 5 min. Slides were dehydrated and mounted with large coverslips using xylene alternative mountant.
PL4 and placental stromal cells were fixed in 4% paraformaldehyde for 15 min, permeabilised by incubating them in 0.1% Triton X100 in PBS for 10 min, then washed in PBS. Primary antibody/biotinylated aptamers in PBS were added and incubated for 1h at room temperature (1∶100 dilutions for anti-heparanase and anti-cytokeratin 7, neat for control mouse antibody and 1∶200 dilutions for all aptamers). After 3×5 min washes in PBS, secondary antibodies were added at 1∶200 to Hpa1 and control mouse labelled coverslips only and incubated for 1h at room temperature (aptamer-labelled coverslips were left in PBS). After washing in PBS (3×5 min), streptavidin-FITC conjugate was added to all coverslips at a 1∶50 dilution of stock and incubated for 1h at room temperature underneath a cover to preserve fluorescence. After a further 3 PBS washes, coverslips were blotted on a soft tissue and mounted using Vectashield mounting medium (Vector), containing propidium iodide.
10 mm tissue culture inserts with an 8 µm pore size (Nunc, Fisher Scientific, UK) were placed into each experimental well of a sterile 24-well plate (Nunc, Fisher Scientific, UK). One coverslip per experiment was sterilised in IMS to be used as an indicator of cell confluency throughout the experiment. 20 µl Matrigel (BD Discovery Labware, Bedford, MA, USA) previously diluted to working concentration; (1∶8 in serum-free medium) was spread over each insert then left to dry in the incubator for 30 min.
500 µl medium was added around the edge of each insert and then 400 µl medium plus 6×104 cells in 100 µl medium was placed on the top of the Matrigel and left to adhere for 1h in the incubator. The medium from both the insert and the well was removed then replaced with aptamer/antibody/control solution (all at 1∶100 dilutions in fresh medium); 500 µl each into the insert and the well, and the plate was incubated for 24h. The cells were fixed in 4% paraformaldehyde for 15 min and permeabilised in 0.1% Triton X100 for 10 min, then stored in PBS @4°C until they were ready to be stained. The insides of each membrane were wiped with a cotton bud to remove all cells, leaving only the cells on the underside, which were then stained with freshly filtered haematoxylin. After a PBS wash, the inserts were plunged into a beaker of hot water to activate the stain. The insides of each membrane were once again wiped with a cotton bud and removed from the transwell, then placed on slides and mounted. The slides were viewed under light microscope at ×10 magnification, eight to ten representative areas were selected and the cells counted. Data were represented as the mean ± standard deviation and an unpaired two-tailed t-test was conducted to assess the significance of the results.

subset: commoncrawl


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Roofing Contractor In Wright FL
Are you looking for Wright FL Roof Repair that you can afford? CALL 850-344-1629.
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With about millions of apps strolling in several app stores and hundreds of apps getting submitted daily, isn't it obvious that the app space is the toughest and competitive one? Apple's App Store and Android's Play Store are unquestionably the two most prominent app stores at present that feature million of astounding mobile applications and represent the greatest malls of the technology world. However, not every of them get marketed in the right manner and gain profound prominence in the stores. As the stores are the only distribution platforms where users visit to get appropriate mobile applications that will best serve their interests or needs, marketers or owners deliberately needs some surefire ways to help their app featured at a winsome position in the store.#1 Build an app that is salient and unique in purposeThe first thing that appreneurs should know that the stores do not acknowledge low-quality stuff. Thus, to get the approval seal from them, one must make their app a stellar and offbeat by incorporating incomparable features.
#2 Make sure it has uniform usabilityOne effective way to show that your application is dedicated one and deserves great prominence in the store is making it universal. Owners require to create apps that work well on all robust mobile OS platforms and devices, including Android versions, iPhones, iPad and even on smart wearables.#3 Comes with latest featuresBesides, checking the app's compatibility with the different OS versions and devices, it's also imperative for owners to incorporate or make use of the newest features of Android or iOS. This ensures that the application developed will be providing an enriching experience to users.#4 Running frequent updates and roll on new featuresConstantly running updates and adding up improved features surely aid in scaling up an app's position in the store. This is because the ratings improve following every update and stores take the users ratings into consideration.#5 Localisation is the keyLocalisation is a prerequisite for any path-breaking app idea that is to flourish in wider markets and over cross-border nations. It cannot be targeting all of the global audience and hence owners need to localise its approach, support native languages and incorporate functions suiting to regional preferences.#6 Optimising techniques for listing in the storeThe work does not end once an app gets listed among the top lists. What if the listing is disorganised with no proper title, wordings, and visuals of the application? Surely, no users will be hitting the download/install button. Thus, appreneurs need to brush up their app's listing with a great title, promo message, and screenshots.#7 Choosing relevant and fitting keywordsThe only way users will know about your app's name or find it in the stores, is by typing the words that represent its utility/purpose in the search fields. So, surely the makers should stuff the right set of keywords on the name and description that will make the app easily discovered out in the search fields.#8 Adding up luring visualsThe role of graphics can never be underestimated. From icon to the pages, everything needs to be appealing to the users. Hence, the screenshots that represent the app in the listing should be visually attractive.
#9 Collecting many users feedbackAn app can be spotted as a popular one in the stores if it has enough positive comments and reviews from existing user base. More constructive feedbacks encourage the users to install them.#10 Appealing to the niche segmentIf owners can nail a unique purpose to target the niche segment beautifully, they can assure that their app will top the list in respective category in the store. Further, focussing on the niche audience helps inevitably in outpacing the competition in the crowded marketspace.While following this easy guidance can help owners frantically in boosting their prominence in the stores, there is also the need for tracking key performance metrics like usage rate, downloads times, session rate, uninstallation rate to perceive the actual position of the app to its target users.


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January 7, 2013
See what the Arnold renderer can do even outside big VFX studios with this 250-million-particle 3D fractal. Read More »
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Material authoring software gets support for the AxF material format, plus seven new filters and noises. Read more »
October 20, 2017
Big update adds brush organisation options, automated stroke smoothing, natural media brushes from Kylebrush.com. Read more »
October 19, 2017
Videos: Check out this intuitive new V-Ray powered rendering and compositing tool, targeted at 'graphic designers, not 3D experts'. Read more »
October 19, 2017 | 1 comment
Videos: see the new tools for editing 360-degree VR video and creating data-driven animation. Read more »
The Blur Studio artist discusses his award-winning short, The Legion, and new CG project The Vikings. Read more »
July 18, 2017
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The Cell Phone I Currently Have
The samsung Instinct s30. Waste of 500 dollars. It might be worth about 30 at the most. The speaker in it is awful, it has limited applications that consist almost completely of games, and the features on it that are supposedly the "iPhone killer" that sprint puts out are all now on the latest iPhone. I seriously can't wait until August when my contract runs out and I am free to switch to AT&T and get an iPhone.
metalhead777 18-21, M 0 Feb 22, 2010


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Wednesday, July 1, 2009
Eclipse will begin production when?
August 17, 2009 is when Eclipse begins production! Woot-a-hoot-toot!
XOXO, Anna~Admin at 10:32 PM
Labels: eclipse, filming, movies, production
1 comment:
- AnonymousJuly 2, 2009 at 6:31 PM
That's awesome it starts filming on my birthdayReplyDelete
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Oak Rd, Lake Arrowhead CA, 92385 (Land Lot)
Sold Price:
Status: Sold
Last Updated: 10/20/2017 11:52 PM
Description for Oak Rd Lake Arrowhead, CA 92385
Approx 7,236 sq. ft. on Oak Rd in the Skyforest area above Lake Arrowhead. Adjacent to 781 Oak Ave,
Sold Price:
Sold Date:09/25/2015
San Bernardino
Approx 7,236 sq. ft. on Oak Rd in the Skyforest area above Lake Arrowhead. Adjacent to 781 Oak Ave
Listing Information
Room Information
Exterior / Lot Features
Mountain, Trees/Woods
Raw La, Rural, Mountains
Financial Considerations
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Lake Arrowhead Real Estate
Lake Arrowhead is located in California. Lake Arrowhead, California 92385 has a population of 11,255.
The median household income in Lake Arrowhead, California 92385 is $64,461. The median household income for the surrounding county is $54,100 compared to the national median of $53,482. The median age of people living in Lake Arrowhead 92385 is 42.5 years.
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text: Trippy psychedelic simulation / animation of a DMT experience By 216. Published on March 25, 2016. 0 No animation can truly depict what happens in a DMT trip, but here is an attempt. A tribute to Terence McKenna. We hope you enjoy this educational video to better help you undertand psychedelic experiences.


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Teacher's gifts are always a bit of a challenge. You want something nice to express your gratitude, but you also want to know it is something that is going to get used and enjoyed. Continue reading "Kit Kat Teacher's Gift"
Teacher's gifts are always a bit of a challenge. You want something nice to express your gratitude, but you also want to know it is something that is going to get used and enjoyed. Continue reading "Kit Kat Teacher's Gift"
This week we visited the Lego Store and I am excited to share that we came out with a fun free mini build and brand new Lego Batman Movie set that cost us next to nothing. Thanks to the Lego VIP program and monthly in-store events, there are two easy ways to get your hands on some FREE Lego at the Lego Store.
Continue reading "Lego Store VIP Program and FREE Monthly Mini Builds"
Somewhere between having 2 kids and becoming a stay at home mom, I became a coffee drinker. I managed to make it through 4 years of university without touching a cup of coffee, but the sleepless nights with newborns and long days with toddlers quickly turned it into my preferred form of caffeine.
We were recently scent (teehee) these adorable Whiffer Sniffers toys for review and when our box of goodies arrived, my kids and I couldn't wait to get into the round plastic packages.
On Wednesday I did something I said I wasn't going to do as a parent; I let my son play hooky from school. I had a chance to meet a friend and decided it wouldn't be the end of the world if I let my son skip one day of Kindergarten to come along and play a round of minigolf with his sister and my friend's son. Hopefully this doesn't bite me in the butt later down the road!
Since we were already out and about, we also decided to meet up with my husband for lunch. We ended up with a bit of time to kill in between, so I decided to take a stroll through Chapters and finally check out the new American Girl section in the West Edmonton Mall store.
On our way out of the children's section of the store, I happened upon this beautiful Finding Dory inspired book on the shelf of Staff Picks. I was immediately drawn to Three Little Words because of the soft watercolors and beautiful imagery, and once I read the message inside I knew it was one I wanted to add to our collection.
We had a lot of great moments on our trip to Disneyland this past February, but I think my absolute favorite moment was my 2 year old belting out her own rendition of Let it Go during the Frozen Sing-Along.
Back in September we went to Toys R Us for their annual Play Day event and one of the toy samples we got was this fun little Qixel sword. My 5 year old son is huge into Minecraft at the moment so when he received the small pack of 8 bit pixel beads to create a Minecraft-like sword, he was very excited to get home and try it out.


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New Delhi, Aug. 23: An extinct, nameless tongue spoken by some of the world's earliest farmers more than 8,000 years ago in Turkey was the likely root of the Indo-European languages collectively spoken today by nearly three billion people worldwide.
A new study has suggested that the fertile land of Anatolia in present-day Turkey was the geographical origin of more than 400 languages — from ancient Greek to English, from Persian to Bengali — that make up the giant Indo-European language family.
The study by an international team of scientists challenges a long-standing theory that the Indo-European language family originated in the steppes of Central Asia about 6,000 years ago and was dispersed by nomadic, pastoral people called the Kurgans.
"Linguists have wondered about the origin of the Indo-European family for 200 years," said Quentin Atkinson, a psychologist and a team member at the University of Auckland, New Zealand. The study findings will appear in the US journal Science on Friday.
Language historians have debated two hypotheses, implying different roots for the Indo-European languages in geography and time. The widely accepted hypothesis puts the origin in the steppes of Central Asia about 6,000 years ago. But the alternative theory proposed by British archaeologist Colin Renfrew in 1987 argued for an origin in the farming communities of Anatolia.
Atkinson and his colleagues borrowed a technique used by disease detectives to trace the origins of outbreaks of viruses to explore the origin of the Indo-European languages.
Virologists analyse genetic material to study changes in viruses and determine their sites of origin. The linguists looked for words called cognates that share a common origin across languages — such as mother, mutter, madre, ma or water, wasser, acqua or nero — and analysed their changes over time and place to trace the root of the Indo-European languages.
The new evidence suggests that the root language of this family emerged in Anatolia between 7,100 years and 10,400 years ago, Atkinson told The Telegraph. The researchers say their results agree with Renfrew's hypothesis that the Indo-European family began to diverge with the spread of agriculture from Anatolia between 8,000 years and 9,500 years ago.
"This is exciting because it brings a new technique to probe the antiquity of languages," said Anvita Abbi, chairperson of linguistics at the Jawaharlal Nehru University, New Delhi, who was not associated with the study. "There has been a need for new ideas because contact between languages can confound results from traditional historical or comparative methods," Abbi said.
The new study has also generated a family tree of Indo-European languages displaying the divergence of languages over the past 8,000 years, showing the emergence of several modern Indian languages from this family within the past 1,000 years.
Indian language researchers say the family tree shows divergence patterns known through historical and comparative studies. For example, it shows that Bengali had shared a common ancestor with Odiya and Assamese about 1000 years ago, while Hindi and Urdu had a common ancestor about 700 years ago. But the uncertainty over actual dates of divergence of languages may run into hundreds of years.
The Central Asian origin hypothesis was based on observations that most Indo-European languages have similar words in their vocabulary relating to wagons and wheels, said Michael Dunn, a research group leader at the Max Planck Institute for Psycholinguistics in the Netherlands. For example, the words for horse, wheel or yoke are similar across many subfamilies of Indo-European languages.
"Archaeological evidence suggests that wagons and wheels also originated about 6,000 years ago in the steppes of Central Asia," Dunn told The Telegraph. "The Central Asian hypothesis claimed that the technology of wagons and wheels spread along with the languages," said Dunn a specialist in the evolution of languages and cultures, and a member of the research team.
However, Dunn said, the new analysis does not find good evidence of this shared wagons and wheels vocabulary in the earliest branch of the Indo-European family — the Anatolian branch.
"Our results support the idea that the (earliest) root was in Anatolia, but most of the branches of the Indo-European family also share a common ancestor about 6,000 years ago in the steppes," he said.
"The new results seem important because numerous studies of Indo-European origins have produced inconclusive results," said Ali Fatihi, professor and chairman of linguistics at the Aligarh Muslim University, who was not associated with the study.
Atkinson and his colleagues say they have tried many ways to test the robustness of their results.
For example, they assumed that water — a sea or an ocean — would pose a major barrier to the expansion of languages. They assumed rates of movement across water to be 10-fold or 100-fold less likely than rates of movement across land. "In each case, we continued to find strong support for the Anatolian theory," the researchers have said in a document explaining their work.
The researchers also chose cognates carefully to avoid similar-sounding words that may have emerged through language contact — one language borrowing from another. They picked what linguistics call "basic vocabulary" nouns such as mother, father, hand, eye, water, fire or verbs such as run, walk or push that are relatively universal and unlikely to be borrowed from other languages.
But both Abbi and Fatihi cautioned that the linguistic community is likely to call for more research before closing the debate. "Contacts between languages can sometimes interfere with analysis — for instance, mayura for peacock in Sanskrit sounds similar to mayil for peacock in Malayalam, but they're not cognate words," Abbi. Fatihi said the Anatolian hypothesis would need further elaboration.
The research was carried out by an international interdiscplinary team, the other coauthors in the study: computer scientists Remco Bouckaert and Alexei Drummond in Auckland, virologist Philippe Lemey in Belgium, linguists Simon Greenhill and Russel Gray in Auckland, and bioinformatics specialist Marc Suchard in Los Angeles, and Alexander Alekseyenko in New York.


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Body found by bicyclist in Lowell state forest
LOWELL, MASS. >> Authorities say a body was found on a state forest trail in Lowell over the weekend.
Crews were called to the Lowell-Dracut-Tyngsboro State Forest around 4:30 p.m. Saturday when a bicyclist reported finding an unresponsive man on the off-road path. He was pronounced dead at the scene. His identity wasn't released.
Middlesex District Attorney's office spokesperson Elizabeth Vlock says the death is not considered suspicious.
Authorities are investigating.
If you'd like to leave a comment (or a tip or a question) about this story with the editors, please email us. We also welcome letters to the editor for publication; you can do that by filling out our letters form and submitting it to the newsroom.


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Today I was going to write about Tentacle Grape, the soda-pop for hentai* enthusiasts. Then I somehow got sidetracked and found myself looking at the Köppen Climate Classification and then found myself looking at Greenland. I don't know why.
But remember when we had our fun with Wyoming? This is really kind of the same thing. Do you want to see the capital and largest city in Greenland, Nuuk?its Wikipedia entry, look at the pictures of the University of Greenland and the Nuuk Art Museum. The place is tiny.
I kind of want to go check it out.
Problem is that I don't speak Greenlandic.
* Not even the Wikipedia entry is safe for work.
04 August, 2011
Have you ever wondered what goes on in Greenland?
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The Youngest Country of the World!
Did you know…Following more than seven decades of Yugoslav/Serbian government, Kosovo declared its independence on February 17, 2008. Hence, the Connecticut-size land made the world headlines when became the youngest country in the first decade of the 21st century. Ten years before, it was not an independent nation in Europe compared to its neighbors — for example, Croatia, Slovenia, Bosnia Hercegovina. At the same time, Kosovo boasted one of Europe's last wars, an ethnic-based conflict, where were killed more than 10,000 persons. From the end of the Cold War to the beginning of the 21st century, it had not been neither prosperous nor stable. In those circumstances, Kosovo Pristina stood as the poorest region on the European mainland. Later on, Kosovo's independence was backed by America, Albania, and Great Britain. In 2009, it was one of the most peaceful countries on the Balkan Peninsula of Europe.
Did you know… This Southeastern European nation has a population of about 2,500,000. It ranks 148th in population among the countries of the world. Around 88 per cent of the nation's population is made up of Albanians. There are also other ethnic groups: Serbs, Bosniaks, Goranis, Roma, Turks, Ashkalis, Egyptians.
Did you know…Education and technology have received increased emphasis in this landlocked country since it became independent in the first decade of the 21st century.
Kosovo & the United States of America
Did you know…On November 23, 1999, President Bill Clinton made history when arrived in Ferizaj, Kosovo. Since then, it was the first official visit by an American Head of State to Kosovo. America's leader Clinton arrived in Ferizaj to an enthusiastic welcome. During his visit, Mr Clinton had called on Kosovo Albanians to forgive the injustices perpetrated against them by the Serbs. This Southeastern European nation Kosovo and capital Pristina has been recognized by Washington since 2008.
Did you know…The landlocked country of Kosovo, that once formed part of Ottoman empire, lies on the Balkan Peninsula of Southeastern Europe. It is bordered by Montenegro on the Northwest, Macedonia on the South, and Albania on the West. This new nation holds a territory of 4,203 square miles (or 10,908 square kilometers). On the other hand, the Kosovar countryside consists mainly of mountains separated by fertile valleys. Unique among European countries, it is about the size of Connecticut, an American state Pristina.
Kosovo's capital
Did you know…Pristina — the country's largest city — is the capital city of Kosovo. It is also the nation's chief commercial, cultural, and industrial center. Since then, Pristina is rich history and friendly people has made it one of the most important metropolises on the Balkan Peninsula. Additionally,it has about 800,000 inhabitants.
Did you know…Albanian, English and Serbian are the national languages. The landlocked nation also has other non-official languages: Gorani, Romani, Bosnian, and Turkish, among others.
Did you know…The most popular sports are: basketball, boxing, canoe, chess, gymnastics, soccer, swimming, table tennis, team handball, track & field, water polo, and wrestling. Nonetheless, the Olympic team — made up of Albanians, Kosovo Serbs, Bosniaks and Goranis — has not competed in the modern Olympic Games. Over the past 14 months, the national government has stepped up efforts to participate in the world championships and multi-sports events. Some of its best athletes living in Western Europe. In 1987, Kosovo's boxer Aziz Salihu earned the gold medal at the Mediterranean Games in Syria. Prisstina
Ecology Pristina
Did you know… More than 25 per cent of its territory is covered by rainforests.
Awards & Prizes
Did you know…The new nation was endorsed by Donald Trump,president of Miss Universe Organization in 2008. Also that year, Miss Kosovo, Zana Krasniqi, under the watchful eye of Fadil Berisha — one of the world's most popular fashion photographers — made the top 15 in Nha Trang, Vietnam. Pristina She was the first Kosovar women to compete in MU. Ironically, Kosovo does not have diplomatic ties with Hanoi. In the following year, in August 2009, the nation's contestant Marigona "Gona" Dragusha finished third in The Bahamas, outpacing 80 other entries. Prior to Miss Kosovo's Bahamas trip, she, who is reminiscent of the world-famous actress Audrey Hepburn, had been training in New York City,along with Hasna Xhukici, Miss Albania Pristina.
Did you know… Apart from Pristina, the region gathers four amazing cities: Dakovica, Kosovska Mitrovica, Peja, and Prizren.
International Organizations
Did you know…Since 2009 this Eastern European nation belongs to the International Monetary Fund (IMF) and the World Bank.
Did you know… On the economic side, Kosovo over the last five decades has changed from a socialist economy to a free market system. From then onwards, a number of foreign corporations operate businesses in the country. Despite being one of Europe's smallest nations, the landlocked country has important mineral resources, including nickel, lignite, lead, chrome, aluminum, and magnesium. But there's more. Much of Europe's coal wealth lies in Kosovo. The resources could provide for economic growth to Pristina if those natural resources were used more fully. Additionally, Kosovo is endowed with fertil soil. Nature-based tourism is a new source of income.
Did you know…Deravica is the nation's tallest peak: it rises 8,714 feet (2,656 meters) above sea level.
Famous Kosovars
Did you know… The country's has produced a number of performers/artists, including Melihate Ajeti (actress), Adekina Ismajli (singer), Shaban Gashi (photographer), Akil Mark Koci (composer), Esat Valla (painter) and a host of other pristina . It has also produced many fine writers, among them Xhevdet Bajraj and Eqrem Basha. However, few of them are known outside the country.
Foreign Relations
Did you know…During the 1990s and early 2000s, Kosovo worked to establish ties with several republics. So far, the new nation has been internationally recognized by 62 member countries of the United Nations, including the United States, Australia, France, Turkey, Germany, and the United Kingdom. Meanwhile, the new country receives continued support and aid from the US and European Union.
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Cheers! McMenamins toasts $6.3M in crowdfunding for Bothell project
McMenamins Inc. has closed its first-ever outside funding round, securing $6.3 million from a crew of mostly Northwest investors for its largest project to date: turning an old school in downtown Bothell into a hotel and entertainment complex.
Monday's announcement clears the way for construction to begin late next month on the $25.3 million Anderson School project, said company officials who hope to open the property in November 2014. Built in the 1930s, the art-deco style school has long been vacant.
Portland-based McMenamins, which operates 52 hotels, pubs, breweries and entertainment venues in Oregon and Washington, opted to raise $8 million for the Bothell project from outside investors. Until now, it had self-funded projects.
"We got so frustrated going through traditional channels," Mike McMenamin said during an interview this spring with the Business Journal, explaining the company's decision to seek outside funding. "It would be fun to get some people involved with some intelligence," he joked.
A company spokeswoman on Monday said that although McMenamins didn't raise the entire $8 million, the company was satisfied with the quality of the 23 investors that joined its team. The average investment was around $274,000.
McMenamins believes the offering is one of the largest real estate offerings of its kind in the Northwest to be completed without the assistance of a third-party investment facilitator.
McMenamins will complete the project funding with a combination of approved loans and equity. Other funding sources includes an $18 million loan from HomeStreet Bank and $1 million in equity from McMenamins. In addition, the company cut $700,000 from the construction budget.
The Anderson School project is modeled after the company's Kennedy School in Portland. In Bothell, the old schoolhouse will be turned into the hotel. On the top floor there will be a "principal's office" where guests will be served coffee, wine and beer because when you're in school "you've got to go to the principal's office," Brian McMenamin said this spring..
The company has taken on similarly large projects, but in phases. McMenamins plans to complete the six-acre Bothell project all at once. The company expects the Anderson School will become its second busiest outlet after the Edgefield complex in Troutdale, Ore.
McMenamins estimates that up to 200 people will work, part and full time at Anderson School.
McMenamins also is working on a project in downtown Tacoma, where it hopes to turn an an old Elks Club into a hotel, brewery and entertainment venue.
"[Bothell] is first in line and we would like to get to [Tacoma] after," Mike McMenamin said this spring.


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Spent just one night at Harvest Inn to celebrate a milestone birthday, and it was really wonderful. Room was excellent, comfortable and spacious... and the large private deck was spectacular for the unobstructed vineyard view and quiet sunset. No traffic noise from the highway in room 304, and it's just steps to the spa and pool. Husband had a double dip in the spa and loved it. The attention to detail in the rooms is worth noting, with lots of little touches I appreciated. AND, the friendly, accommodating staff engage with guests, say good morning and good evening, and work their tails off. We felt welcome right from the get-go. The next morning one nice staffer even helped me carry a rather heavy breakfast tray back to my room. The grounds are gorgeous and fun to explore. You can't go wrong with room 304! (And thanks for a great time, Debbie.)
- Official Description (provided by the hotel):
- Voted the #3 hotel in Northern California by Condé Nast Traveler's Readers Choice Awards 2016, Harvest Inn by Charlie Palmer is an idyllic resort designed to celebrate the vineyard way of life, with 78 luxurious accommodations nestled into five uniquely crafted neighborhoods, two secluded swimming pools, and a plush spa with indoor and outdoor facilities. Surrounded by the lush landscaping of expansive clipped lawns and serene shaded groves, partially forested by towering redwoods, Harvest Inn also is home to gardens of agricultural botanicals. Although well situated in proximity to the hub of activity in historic St Helena, Harvest Inn offers picturesque privacy and a "let's get lost" feeling of total relaxation. In classic California fashion, the architecture and land are in harmony, making Harvest Inn an integral part of the terrain. The distinctive mixing of heritage and modern style seen in the richly stained wood, leaded glass panels, and exterior stone as well as Tudor stucco with timber framing adds up to a storybook setting that is both rustic and elegant. As comfortable as it is beautiful, Harvest Inn welcomes both families and friends with its charming warmth and friendly ambiance. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Expedia, Travelocity, Hotels.com, Orbitz, Cheap Tickets, Priceline, Hotwire, TripOnline SA, getaroom.com and Evoline ltd so you can book your Harvest Inn by Charlie Palmer reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Harvest Hotel St. Helena
- Harvest Inn Napa
- Harvest St Helena
- Harvest Inn By Charlie Palmer St. Helena, CA - Napa Valley


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Spring Arbor University guided tours
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Find info concerning Spring Arbor University guided tours, and registering for elective lectures and seminars. Which college degrees give you the best chances of entering a successful career path after graduation? Concentrating on Spring Arbor University guided tours, for example, may give you additional focus in the admissions selection process. Check with the admissions office for assistance with prerequisites, course registration deadlines, and college degree program requirements. Please use the form above to request admissions info for Spring Arbor University.
The US News & World Report rankings are based on data which US News collects, either from an annual survey, or from the school's website. Critics charge that US News & World Report changes its grading methodology every other year so that their college rankings will change of necessity. Forbes Magazine also publishes college rankings & school listings. Although best known for their Forbes 400 list, the Forbes college rankings have been getting a lot of attention.
If you are interested in military service, the Reserve Officers Training Corps (ROTC) program will pay for your college tuition as well as provide a small stipend, as long as you're attending school full-time. There is no fixed military commitment for the first year, allowing you to enroll in ROTC on a trial basis. If you then choose to commit to a military career, ROTC scholarships pay for almost all tuition and fees, and textbook costs, for up to four years of college. Beyond major requirements within the admissions department, you may consider North Arkansas College remedial courses for complementary electives to your primary course of study.
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Apple has finally revised its 12-inch MacBook for 2017. Revealed at this year's WWDC 2017 keynote, the new MacBook brings itself more in line with the hardware found inside the MacBook Pro 2017 models
This includes, of course, the latest Intel Kaby Lake processors and 50% faster SSDs inside.
Getting right into it, here's everything you need to know regarding the newly-debuted 12-inch MacBook for 2017.
Cut to the chase
- What is it? The new 12-inch MacBook refresh
- When is it out? New models are shipping now
- What will it cost? Starting at $1,299, just like before
MacBook 2017 release date
A report out of Bloomberg last month quoted sources "familiar with the matter" stating that Apple plans to debut three different MacBooks during its Worldwide Developers Conference (WWDC) keynote held on June 5, 2017.
Now, we know for certain that the new MacBook models have begun shipping on June 5, no pre-order needed. After you've ordered online, you can choose to receive your new device in as fast as two days, as of this writing.
MacBook 2017 price
Absolutely nothing has changed about the MacBook price for 2017, despite the internal hardware upgrades. (Frankly, as it should be.)
So, the 12-inch MacBook will start at the same price as before: $1,299/£1,249/AU$1,899 to start. However, Apple's secretly made an interesting move in regards to MacBook pricing.
For 300 more in any currency, Apple is now selling a 12-inch MacBook with an Intel Core i5 processor and 512GB of SSD storage. Then, if you need even more power, you can upgrade to an i7 processor for $150 (£135, AU$240) on top of that.
MacBook 2017 specs
Not much concrete information regarding the 12-inch MacBook's internals was revealed on-stage at WWDC. However, we now know much more about what's new inside the laptop.
Naturally, the new 12-inch MacBook for 2017 rocks Intel's latest Kaby Lake, 7th generation processors as well as solid-state drives that are 50% faster. However, Apple has also introduced Intel's more powerful Core i5 processor with a 1.3GHz clock speed to the platform – there's the option to upgrade to an Intel Core i7 chip, too.
Mind, however, that these are likely Core i-Y series chips, essentially a re-branding of the Core M line with much of the same power profile. Also, Apple still hasn't bothered to upgrade the MacBook's poor, 480p webcam. (Seemingly nothing regarding battery life has changed.)
If the past two years have been any indication, the 12-inch MacBook has struggled with power and memory. Luckily, Apple has resolved much of the latter as well. That's right, you can now opt for 16GB of DDR3 memory for $200 (£180, AU$320) over the price of the 8GB config.
The keyboard has also seen some improvement. Whereas the last two MacBooks have used extremely low-profile, first-generation butterfly keys, the 2017 MacBook makes the move to Apple's second-gen butterfly mechanism used by the latest MacBook Pros.
But, if you don't want to spend a fortune on a MacBook laptop, Apple's also given the MacBook Air a slight boost with a current-generation Intel core i5 processor clocked at 1.8GHz – that's a 200MHz increase from the previous model.
- These are the best laptops that the MacBook is up against


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Hello Poe Family and Friends! We are so excited about this year's auction, POE RAVEN'S ANIMAL HOUSE! Please celebrate with us on Saturday, April 8, 2017. We will rock out at Warehouse Live from 6 pm to 11 pm with Dysfunkshun Junkshun. We will start off with a Greek spread from Niko Niko's, then late night snacks from Whataburger and Dominoes! It will be the best frat party of the year! TOGA! TOGA! TOGA!
As you all know it takes a lot to pull off our biggest fundraiser so we need your help! Click the links below to find out more information about all of the ways you can help!
- Donate as an underwriter
- Donate an auction item(s)
- Host an auction social
- Purchase tickets for the big event
- Purchase auction t-shirts
- Volunteer to help with securing auction items, class baskets, socials, class art, etc.
If interested in supporting auction or have additional questions, please email Annie Polasek and Shannon Witz at email@example.com.
They promise you will have nothing but FUN!!


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Itawamba Community College basketball players
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Get the facts about Itawamba Community College basketball players, and registering for elective lectures and seminars. Not all recruiting is done like NCAA Division I teams. College coaches are more interested in players who already know about their team and college, so do your research before visiting a college campus in person. Finally, check with your major department for assistance with prerequisites, tuition payment deadlines, and Itawamba Community College Basketball information. Please use the form above to request admissions info for Itawamba Community College.
Always maintain a positive attitude, especially when you're in pain, or losing a game. Be a good sport, and keep trying. Believe you'll be successful, act like you can still win the game, and then go out and make it happen. Be aggressive, and make a second try on a given play if you have time. It's one thing to make a good effort, but great players keep trying until they succeed, no matter how many years of team practice that takes.
If you get lazy, and decide to take it easy during practice, coaches will take notice. Push yourself, work hard, and you'll improve as a player. It's important to find a position that you really like to play, not just settle for what you're good at. Over the long haul, you'll have a better athletic career. Students must meet specific eligibility requirements each year to participate in Aligarh Muslim University basketball game schedule. Beyond consideration for Itawamba Community College basketball players, you may think about Saint Louis University undergraduate classes online for complementary electives to your primary course of study.
Athletic Trainer, Program Manager
Agility Health
Program Manager, Certified Athletic Trainer. Licensed within the State of Florida as an Athletic Trainer or eligible for FL licensure.
2 days ago Supervisor of Newborn Screening Lab
Community Regional Medical Center
Expectations are to performance annual evaluations of all staff in out appraisal process, in a consistent and timely manner.
6 days ago Sports Coach (Basketball & Flag Football)
YMCA of the Suncoast
The YMCA coach will work together with the assistant coaches to ensure that their team has strong leadership.
7 days ago Youth Programs Coach/Staff Assistant
Miami Dolphins
Played HS, College or coaches football on any level. They will work as a football coach while assisting with setting up all Miami Dolphins Summer programs.
3 days ago Personal Trainer- Golf Fitness
Lifetime Fitness
Nutrition Coaching, Nutritional Products, Supplements, Registered Dietitians. Private Training, Weight Loss, Metabolic Coaching, TEAM Classes, Pilates..
7 days ago


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- Omar El Ayach, Sridhar Rajagopal, Shadi Abu-Surra, Zhouyue Pi, Robert W. Heath
- IEEE Trans. Wireless Communications
- 2014
Millimeter wave (mmWave) signals experience orders-of-magnitude more pathloss than the microwave signals currently used in most wireless applications. MmWave systems must therefore leverage large antenna arrays, made possible by the decrease in wavelength, to combat pathloss with beamforming gain. Beamforming with multiple data streams, known as precoding,… (More)
- Ahmed Alkhateeb, Omar El Ayach, Geert Leus, Robert W. Heath
- IEEE Journal of Selected Topics in Signal…
- 2014
Millimeter wave (mmWave) cellular systems will enable gigabit-per-second data rates thanks to the large bandwidth available at mmWave frequencies. To realize sufficient link margin, mmWave systems will employ directional beamforming with large antenna arrays at both the transmitter and receiver. Due to the high cost and power consumption of gigasample… (More)
- Omar El Ayach, Robert W. Heath
- IEEE Trans. Wireless Communications
- 2012
Interference alignment (IA) is a multiplexing gain optimal transmission strategy for the interference channel. While the achieved sum rate with IA is much higher than previously thought possible, the improvement often comes at the cost of requiring network channel state information at the transmitters. This can be achieved by explicit feedback, a flexible… (More)
- Omar El Ayach, Steven W. Peters, Robert W. Heath
- IEEE Trans. Vehicular Technology
- 2010
Interference alignment (IA) has been shown to achieve the maximum achievable degrees of freedom in the interference channel. This results in sum rate scaling linearly with the number of users in the high signal-to-noise-ratio (SNR) regime. Linear scaling is achieved by precoding transmitted signals to align interference subspaces at the receivers, given… (More)
- Salam Akoum, Omar El Ayach, Robert W. Heath
- 2012
- Omar El Ayach, Robert W. Heath, Shadi Abu-Surra, Sridhar Rajagopal, Zhouyue Pi
- 2012 IEEE 13th International Workshop on Signal…
- 2012
Millimeter wave (mmWave) systems must overcome the heavy attenuation at high frequency to support high-throughput wireless communication. The small wavelength in mmWave systems enables beamforming using large antenna arrays to combat path loss with large array gain. Beamforming in traditional microwave systems is often done at baseband for maximum… (More)
- Omar El Ayach, Angel E. Lozano, Robert W. Heath
- IEEE Trans. Wireless Communications
- 2012
Interference alignment (IA) is a cooperative transmission strategy that, under some conditions, achieves the interference channel's maximum number of degrees of freedom. Realizing IA gains, however, is contingent upon providing transmitters with sufficiently accurate channel knowledge. In this paper, we study the performance of IA in multiple-input… (More)
- Omar El Ayach, Steven W. Peters, Robert W. Heath
- IEEE Wireless Commun.
- 2013
Interference alignment (IA) is a revolutionary wireless transmission strategy that reduces the impact of interference. The idea of interference alignment is to coordinate multiple transmitters so that their mutual interference aligns at the receivers, facilitating simple interference cancellation techniques. Since IA's inception, researchers have… (More)
- Omar El Ayach, Robert W. Heath, Sridhar Rajagopal, Zhouyue Pi
- 2013