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text: 12 Aug 2016 Home » Selling » Sales at Highest Pace in 9 Years!Sales at Highest Pace in 9 Years! by Beth | posted in: Front Page, Listing, Selling | 0 Some Highlights: Sales of existing homes reached the highest annual pace in over 9 years at 5.29 million. Inventory remains below the 6-month norm and prices are still on the rise. Interest rates are at a historic low of 3.48%. Share this:EmailTweetPocketMoreShare on TumblrPrint

subset: commoncrawl


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Silicone Popcorn Maker, Microwave Corn Popper, Healthy, Gourmet, Easy To.
Silicone Popcorn Maker, Microwave Corn Popper, Healthy, Gourmet, Easy To Use, Collapsible Countertop Bowl. Best snacks in the Usa.
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text: padnag definition October 16, 2017 AZ Dictionary Link to this page noun: An ambling nag. An ambling nag. An ambling nag; an easy-going pad. View More others: To drive a pad-nag. Related Sources Definition for "padnag" An ambling nag. View More Sentence for "padnag" Now is not this better than… View More How would you define padnag? All the definitions on AZdictionary were written by people just like you. Now's your chance to add your own! Your Full Name Your definition Post Definition


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Llanberis accommodation
Gamekeeper's Cottage
- Holiday Cottage
- Y Felinheli
- Sleeps 2 to 6, 3 bedrooms
- £440 to £965 per week
An idyllic cottage in a great location. Set in peaceful, countryside surroundings, Gamekeeper's cottage is a fab choice for families or friends looking for a quiet get together but also wish to be in easy reach of the coast, Snowdonia National Park. Distance 5.1 miles.
Ty Capel
- Self Catering
- Beddgelert
- Sleeps 2 to 9, 4 bedrooms
- £450 to £1000 per week
This former chapel house stands in its own grounds on the edge of the village of Rhyd Ddu with outstanding views of Snowdon. Recently extended and refurbished, it's the ideal base for an active or relaxing holiday. Internet access available. Distance 4.5 miles.
Boulder Adventures
- Hostel and Activity Centre
- Llanberis
- Sleeps 1 to 35, 7 bedrooms
- £18 to £35
The Bryn Du Mountain Centre is ideally situated in Llanberis with views of Snowdon and Padarn Lake. Within 10 minutes walk to Snowdon, Snowdon Mountain Railway, Electric Mountain, The Welsh Slate Museum, Padarn Country Park and Llanberis High Street. Distance 0.1 mile.
- Holiday Cottage
- Beddgelert
- Sleeps up to 6, 3 bedrooms
- £400 to £600 per week
In the village of Rhyd Ddu at the foot of Snowdon, this recently updated holiday cottage has great views of England and Wales' highest mountain. Distance 4.5 miles.
The Lodge Plas Y Nant
- Holiday Cottage
- Betws Garmon
- Sleeps 1 to 4, 1 bedroom
- £275 to £475 per week
This 1890s lodge is in a spectacular valley in the foothills of Mount Snowdon. Tastefully renovated to a high standard, an excellent country retreat, for either a relaxing holiday or outdoor active break. A great location for exploring the local area. Distance 2.8 miles.
Y Gorlan
- Self Catering
- Beddgelert
- Sleeps up to 2, 1 bedroom
- £299 to £595 per week
The perfect country cottage for two, set on a working farm on Snowdon between the villages of Rhyd Ddu and Beddgelert. Luxurious, well equipped accommodation with own hot tub. Many walks from your doorstep including Snowdon and the Nantlle Ridge. Distance 5.2 miles.
- Self Catering
- Caernarfon
- Sleeps up to 7, 4 bedrooms
- £275 to £835
Beautiful Farmhouse two miles from Caernarfon, in a rural setting within walking distance of village of Bontnewydd. Very central - 10 minutes drive from many attractions. The Welsh Highland Railway and cycling/walking route within walking distance. Distance 5.9 miles.
The Summer House
- Holiday Accommodation
- Mynydd Llandegai
- Sleeps 1 to 5, 2 bedrooms
- £185 to £300 per week
Charming cottage with striking panoramic view on secluded farm central to Llanberis, Caernarfon, Bangor, Anglesey and Snowdonia National Park. Great area for biking, horse riding, climbing, watersports, wildlife, walks, high Welsh zip-wire approx 2 miles. Distance 3.9 miles.
Bron Eryri
- Self Catering Accommodation
- Nant Peris
- Sleeps 1 to 6, 3 bedrooms
- £350 to £580 per week
This self catering cottage at the foot of Snowdon, great for exploring Snowdonia National Park and the North Wales coast. Mountain views from all windows. Walk from the front door or visit the local pub for a pint and chat. Distance 2.1 miles.
Ty Twt
- Self Catering
- Beddgelert
- Sleeps 1 to 5, 2 bedrooms
- £360 to £845 per week
A beautifully presented cottage with private hot tub on a footpath up Snowdon, Ty Twt is ideal for walkers and cyclists. With miles of foot- and bridlepaths on your doorstep, it also offers peace and quiet for those wanting a country retreat. Distance 5.2 miles.
Plas y Bryn Chalet Park
- Self Catering Accommodation
- Caernarfon
- Sleeps 1 to 6, 2 bedrooms
- £210 to £680 per week
Close to Caernarfon and stunning beaches, we offer self catering pine lodge and caravan holidays. Set between woodland in the manor house's walled garden we offer safety, seclusion and beautiful Snowdonia views, only 15 minute drive to Llanberis. Distance 5.4 miles.
- Holiday Let
- Beddgelert
- Sleeps 2 to 4, 2 bedrooms
- £240 to £500 per week
Rhyd Ddu is a quiet village at the foot of Snowdon, three miles from Beddgelert. You can relax in the garden with spectacular views of Snowdon and wave to the people passing by on the Welsh Highland steam train. It is an ideal base for a Snowdonia break. Distance 4.5 miles.


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Sridhar Swami
Posted April 16, 2004
Hare Krsna,
Do you sell Sridhar Swami Ministry CDs? (MP3s, DVDs, CDs, etc.). I am also interested in his books as well. Buying all of his life's works will please me dearly. Respond with a price quote or info on how I can purchase this devotee's work.


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Customer Reviews Of:
Barry Bricken Wool Gabardine Pants - Pleats, Cuffs (For Men)
Closeouts. Cuffed, pleated pants bring an element of refinement to the well-dressed gentleman, and these Barry Bricken pants execute the style in a beautifully draping gabardine.
Average Rating based on 37 reviews 4.135135 0 5
Verified Buyer Reviewed by Horseygirl from New Mexico on Thursday, June 18, 2015My husband is a 32/30 and these fit him perfectly. Nice fabric, great look.
Verified Buyer Reviewed by Joseph from pacifica, ca on Friday, June 12, 2015These pants are very comfortable, fit true to size and the material is first rate.
Verified Buyer Reviewed by MH from VA on Saturday, April 4, 2015Well built - need more time to test how thay hold up in travel
Verified Buyer Reviewed by Working day pro from Providence, RI on Tuesday, December 16, 2014These gabardine slacks are light weight and stylish with pleats and cuffs for those not enamored with the skinny leg look that is the trend today. The cut is comfortable and colors most workable for the office or after work.
Verified Buyer Reviewed by Damon from Kennebunk, ME on Monday, November 24, 2014Excellent quality, really nice hand - however the sizing is off considerably. I ordered 36X32 as I wear this size in almost all pant sizes regardless of name brand, but these slacks floated on me. Visited the seamtress at my local cleaner where to my surprise, it is going to cost me an additional $100.00 to have the pants tailored to fit properly. The waist fits fine, but both pairs need to be tapered as well as hemmed. Sometimes a good deal just ins't a good deal after all.
Verified Buyer Reviewed by 593Guy from Virginia on Monday, November 10, 2014I am very happy with these pants. They will replace three pairs of gray wool trousers, each one having at least one thing that keeps them from being great.
Reviewed by MBSierra from NH on Friday, October 24, 2014Fit, but not really well enough for a wool gabardin dress pant to keep. These pants should fit better or at least as well as the Land's cotton chinos, but they're just skimpy enough to compromise that sharp dressed look. Really too bad, because the fabric and colors are perfect.
Verified Buyer Reviewed by Herb from Florida on Monday, May 26, 2014Nice fit and finish. Good price. I have not been disappointed with any product ordered.
Reviewed by MJ from Georgia on Thursday, May 15, 2014Some reviews say the sizing is off, some say it's perfect. Some say the quality is great and some say it is not. It's tough making a purchase decision from the reviews. The pants look great and feel great. The waist size is accurate, however, the length is off. The actual measurement of the 32" inseam that I ordered is 31". The overall length of the pants is 1" shorter than all my other 32" inseam pants. This probably why they are for sale here but it would be nice to know before the purchase.
Verified Buyer Reviewed by My Guy's Wife from West Michigan on Monday, May 12, 2014These seemed like nice pants, but the sizing was way off. We ordered my husband's typical size, and he couldn't come close to fastening them.


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Corporate Profile
CalAmp (NASDAQ: CAMP) is a telematics pioneer leading transformation in a global connected economy. We help reinvent businesses and improve lives around the globe with technology solutions that streamline complex IoT deployments and bring intelligence to the edge. Our software applications, scalable cloud services, and intelligent devices collect and assess business-critical data from mobile assets, cargo, companies, cities and people. We call this The New How, powering autonomous IoT interaction, facilitating efficient decision making, optimizing resource utilization, and improving road safety. CalAmp is headquartered in Irvine, California and has been publicly traded since 1983. LoJack is a wholly owned subsidiary of CalAmp.
Investor Relations Contact


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You are able to log in as anyone. Be careful!
You are able to log in as anyone. Be careful!
n49 2000-2015 | N49 is proudly made in toronto
"I was one of the first customers back in 2004 and I am still LOVING my mattress!"
... quality mattresses and pillows specifically designed to make sleeping more comfortable. The products not only reduce aches and pains but also alleviate allergy symptoms. Memory Foam was initially designed for NASA and was developed by ... Read more
15 Woodlawn Road West, Guelph, ON
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55 Dawson Road, Guelph, ON
685 Speedvale Ave, Guelph, ON
SANIFLO products are used to provide additional facilities in bed-and-breakfast houses, restaurants, factories, as well as in obvious domestic situations; en-suite bathrooms, loft conversions, basement installations, facilities for the elderly and disabled ... Read more
72 Macdonell Street, Guelph, ON
"... Bathrooms were above average in terms of hygiene, for a bar. Special night with that certain someone? Bed and breakfast is quality for the price, I would recommend the steak and eggs if you're ..." Read more


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Scrabble?! EPIZOITE
Is EPIZOITE valid for Scrabble? Words With Friends? Other games?!
Definitions of EPIZOITE in various dictionaries:
- noun - an epizoic organism
There are 8 letters in EPIZOITE: E E I I O P T Z
Scrabble results that can be created with an extra letter added to EPIZOITE
To search all scrabble anagrams of EPIZOITE, to go: EPIZOITE?
Rearrange the letters in EPIZOITE and see some winning combinations
Contextual use of EPIZOITE
About EPIZOITE
What's nearby EPIZOITE
Lookup in Wiki for EPIZOITE
Anagrammer is a game resource site that has been extremely popular with players of popular games like Scrabble, Lexulous, WordFeud, Letterpress, Ruzzle, Hangman and so forth. We maintain regularly updated dictionaries of almost every game out there. To be successful in these board games you must learn as many valid words as possible, but in order to take your game to the next level you also need to improve your anagramming skills, spelling, counting and probability analysis. Make sure to bookmark every unscrambler we provide on this site. Explore deeper into our site and you will find many educational tools, flash cards and so much more that will make you a much better player. This page covers all aspects of EPIZOITE, do not miss the additional links under "More about: EPIZOITE"


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Whether you're taking a road trip through the forests of the Pacific Northwest or trekking through the beautiful deserts of the Southwest, we have road trip and travel stamps that will make you want to take your crafty projects along for the ride! Browse below to find everything from car stamps to map stamps, wood mounted to acrylic cling, backgrounds to phrases. Shop now!
$15.00 $14.24
$6.00 $5.69


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Linda was born and raised in Los Angeles, California. In the early 70's she moved to the Bay Area and now lives in the Oakland Hills.
Linda received her Real Estate license in 1993. Linda's career experience includes escrow as well as loan origination work. Her true career passion, however, is real estate.
Linda's warm manner and excellent listening skills ensure that her clients' needs are fully understood and met. She will work enthusiastically from the beginning of the process to the end to provide a level of service that will exceed client expectations!


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Welcome to...
...Um, I need help!
Need special attention? Our support community is the best place to ask specific questions, and collaborate with us, and other Ranch Manager users.
You will need to create an account to participate in the community.
...Go to the Support Community!
Looking for a Product Update?
You can access product updates for your product directly from the application from the Help menu. Alternatively, the links to the desktop updates are provided below. You can install the iPhone or iPad App updates from the Apple App Store.
Ranch Manager ® is a Registered Trademark of Lion Edge Technologies Inc. Copyright © 1999 - 2017 All Rights Reserved.
Lion Edge Technologies is Family Owned & Operated


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Many people accept their doctor's advice as the gospel. But when your doctor's advice and treatment does not give you the results you want, it may be wise to get a second opinion by a doctor of chiropractic. If your case is the result of misalignment in the spine causing pressure on nerves, no amount of medicine, drugs or surgery will help you. Yours is exclusively a case for the chiropractor. And only the chiropractor can determine whether chiropractic can help you!
What You Should Expect
When you decide to get an opinion from a chiropractor, you can expect to get an expert evaluation and examination of your spine and nervous system. Chiropractors are trained in nerve tracing techniques to determine the cause of your problem. Any area of derangement within the spine and pelvis or abnormal mobility or stiffness in the spine can be a cause for major concern in determining the causative factors of your problem.
Why Suffer?
Too many patients try chiropractic as a last resort after running the gamut of medical tests and x-rays, only to have the doctor tell them, "We can't find anything wrong with you." Medical doctors are not trained in manipulation of the intricate biomechanics of the spine; what may seem insignificant to an M.D. may be cause for major concern to your chiropractor. Millions every year are turning to chiropractic and recovering from ailments they have suffered with for years. Once your condition gets chronic it will continue to get worse until you treat the cause of the problem and not merely the symptoms.
Treat The Problem - Not The Symptom
Don't be disillusioned into believing you are regaining your health every time you receive temporary relief from medication. The condition causing the symptoms is progressively getting worse. Remember - malfunction precedes disease. The nervous system controls the function of every organ, system and tissue cell in the body. Why not get an opinion by today's specialist of the nervous system -- the chiropractor.


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Browse by Eprint ID
Number of items: 1.
Scaife, Anna and Green, David A. and Battye, Richard A. et al. (2007) Constraints on spinning dust towards Galactic targets with the Very Small Array: a tentative detection of excess microwave emission towards 3C396. Monthly Notices of the Royal Astronomical Society, 377 (1). L69-L73. ISSN 0035-8711. http://resolver.caltech.edu/CaltechAUTHORS:20091113-100849088


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The fishings at Laithers extend to approximately 2 miles of the south bank of the lower Deveron, some 3 miles west of Turriff (on the B9024 road to Huntly).
This most attractive stretch of river offers excellent salmon, sea trout and brown trout fishing. There are usually good summer and autumn runs of salmon, with the heavier fish being caught towards the end of the season.
Sea trout provide some exciting dusk and night time fishing in June, July and early August, with the brown trout being at their best in April and May.
THE MIAGGIE AND MIAGGIE POTS (N.B. 'House' Rod retained)
Laithers Estate also owns approximately 330 metres of the North (left) bank of the river formerly part of Carnousie, comprising the Miaggie and Miaggie Pots pools. This is a great advantage to Laithers' fishermen, particularly in respect of the Miaggie Pot Pool which fishes much better off the North bank. The estate retains the right to fish a fifth 'house' rod which will be exercised only occasionally by the owner or his ghillie when water conditions suit. When water conditions are too high to cross the river by wading the house rod may fish on the lower half of the lower beat providing one of the let rods are fishing Miaggie/Miaggie Pots.
The beat is served by an excellent stone-built fishing lodge, providing fishermen with comfortable shelter and lunching facilities. Further fishing huts are situated at Morrisons, Miaggie, Turning Wheel and Lower Heron. The lodge comprises:
Large meeting room with open fireplace, fish room, ghillies' room, locker storage, cooking facilities and W .C.
Two cottages are available to let and preference is given to fishing tenants who rent a cottage along with their fishing. Each cottage is fully furnished. A cooker,
refrigerator and all necessary cooking utensils are provided. Each cottage can sleep 5 people (including camp beds). Bed linen is supplied. No dogs are allowed. Earliest
time for entry into the cottages is 4.00 pm on day of arrival and cottages must be vacated by 10.00 am on day of departure.
Either cottage avialable at £415 each (+ VAT). per week.
This fishery is not able to display catches here, so please use the contact details below for further information
Please take the availability link below and check that the days you want are available. Then follow the instructions at the bottom of that page.
Availability / Prices ******
Stichill House
Scotland TD5 7TB
Tel: 01573 470612
Fax: 01573 470259
Email: firstname.lastname@example.com


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"Noisy Shadows" Wins International Award
Media Release
"Noisy Shadows" Wins International Award
Wellingtonian Branwen Millar (Evening Post Wellingtonian of the Year 2001) has recently received a prestigious American award for playwriting.
In 2005 Millar undertook an exchange to the University of Santa Barbara where she composed her first play Noisy Shadows. The play, which deals with the subjects of media influence and American naivety, was performed in California to sell out seasons and critical acclaim. It caused controversy by beating out 90 scripts from the Californian region to be awarded the Dorothy E Corwin Award for Best New Play, the first time this award had been presented to a non-American.
Millar had never considered playwriting as a career until American award-winning playwright and scholar, Naomi Iizuke singled her out, as someone with a unique talent and voice.
Subsequent to winning the award Millar has been invited to return to America to attend the Californian Summer Theatre Lab, three weeks of workshops run by the America's most important theatre practitioners. She has also changed her career path and is now undertaking the MA in Creative Writing (Scriptwriting) at VUW International Institute of Modern Letters.
Noisy Shadows makes its New Zealand debut at Bats Theatre from 21-26 of March 2006. It is being directed by Theatre Militia's Rachel Lenart with sound design by Emile de la Rey.
"Amazing! Vibrant, original, and theatrically inventive. This is the voice of a new generation of playwrights." Santa Barbara News-Press, California.
What: Noisy Shadows by Branwen
When: 21-26 March 2006, 8pm
Where: BATS Theatre
1 Kent Terrace
Cost: $16/ $12
Phone: (04) 8024175 to book.


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Phew! That was a long post with lots of pictures. Glad to get this post out of the way. Next will probably be my Sephora haul from the VIB 20% off sale. I got my package just a few days ago so hopefully I can take pictures soon and share. Oh, and I'm not sure when I can do the room reveal. I still have some things I want to do but I'm almost "done" for what I can do for now. Hope you're not sick of me yet!
"Before you ask someone why they hate you, ask yourself why you even care." -Unknown


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BauExpo 2018
The construction trade fair in Giessen
Hotel reservation for BauExpo 2018 in Giessen
For the 24th time the trade fair BauExpo 2018 takes place in Giessen. The show promises due to its location in Giessen, large sales and to offer regional buyers a reference market.
The trade fair BauExpo will again hold more than 400 exhibitors on a total area of 16,000 m². Well-known companies present their visitors services, new and reinforced products and innovations in the construction industry. The ecological aspect, the accompanying fair "ENERGY" with various lectures and informations.
Do you need a hotel reservation for BauExpo 2018? Please contact us for suitable hotel deals and hotels near to BauExpo 2018 Exhibition Center. Entrust us with a free search on our inquiry form or call us.
Hotel Agenten offers customized hotel reservation according to your requirements. With the experience of our team, you can select your hotel and get a full consultation and all hotel recommendations free of charge. Send us your request and let us convince you of our hotel booking service.
|15.02.2018 - 18.02.2018
Convention Center Gießen
An der Hessenhalle 11, 35389 Gießen
|Opening hours:
|10:00 - 18:00
BauExpo 2018
Convention Center Gießen
An der Hessenhalle 11, 35389 Gießen
Date: 15.02.2018 - 18.02.2018
|Multiple Hotel Inquiries via Watchlist
|Online Inquiry Management
|Direct Booking
|Guestlist Management
|Booking Management
|Personal Support
The AKZENT Hotel Köhler is located in the center of Giessen, 600 meters from the main railway station. The house has good access to the A485 motorway. Nature lovers will also enjoy the beautiful surr...
2.1 km
2.1 km
71.3 km
0.8 km
The Hotel & Restaurant "Altes Eishaus" is located in Giessen quiet and idyllic directly on the river Lahn. It offers easy access to the Giessener Ring motorway exit. The city center is also only a few...
2.7 km
3.0 km
73.6 km
2.9 km
The Hotel Tandreas is located in Giessen and is easily accessible by car, train and plane. It is a central starting point for numerous sights. The 4-star hotel offers 34 individually furnished comfort...
3.0 km
0.6 km
70.7 km
2.4 km
The BEST WESTERN PLUS Hotel Steinsgarten presents itself as a modern business and conference hotel in the heart of Hesse and offers all the comforts a business or conference guest can expect. All 122 ...
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71.4 km
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The Hotel am Ludwigsplatz is located in the city center of the university town of Giessen, close to the city theater, the university, the town hall and the pedestrian zone. The 33 individually designe...
3.7 km
1.1 km
71.4 km
3.0 km
|Our free service includes


text: December 30, 2016 By C M B D No Comments Customer Bikes, Dream Rides Johnny's Trip Photos! Thanks for Sharing! Post navigation « Previous Article Next Article » Leave a Reply Cancel reply Your email address will not be published. Required fields are marked *Comment Name * Email * Website


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These quick, flavorful noodles with ginger and scallions will rival any take-out variety. Add a soft-boiled egg or sliced chicken for a simple and quick week-night dinner. This recipe serves two.
- 2 Tablespoons grapeseed oil (vegetable or canola will also work)
- 1 large bunch of green onions, sliced
- 2 Tablespoons of roughly chopped cilantro
- 2 Tablespoons of ginger, finely minced
- 1 Tablespoon chopped garlic
- 1 Tablespoon chopped shallots
- 2 teaspoons fish sauce
- 1 Tablespoon toasted sesame seed oil
- 1 tablespoon honey
- 1 teaspoon rice wine vinegar
- 2 teaspoons soy sauce
- 1 crushed red chile pepper or 1 teaspoon red chile flakes
- kosher salt to taste
- 10 ounces noodles of your choice, cooked according to package directions and drained (see note
- Heat up the grapeseed oil in a saucepan over high heat until the oil is hot
- Add the green onions, cilantro, ginger, garlic and shallots at once. Stir the ingredients quickly, to coat them in the hot oil, and immediately take the pan off the heat.
- Add the fish sauce, sesame seed oil, rice wine vinegar, soy sauce, honey, crushed red chile pepper and salt to taste.
- Let sit for 15 minutes. Toss with noodles. Serve immediately.


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"Joy to the World".
It's a phrase that gets a lot of play this time of year, but what does it really mean? From the way it's represented in popular culture, "joy" seems to be referring to a kind of giddy, superficial happiness that comes from buying a new sweater at the Gap or wrapping your hands around a single-use 20oz. disposable cup of Ginger Peppermint Mocha from Starbucks.
I've been contemplating the word joy lately and I've come to understand it as a kind of undifferentiated love — one that isn't specific to any particular individual, thing or deity, but rather a whole-hearted love of Life itself that includes all aspects of existence — including all the less loveable bits like death, taxes and Donald Trump.
We can connect to this all-encompassing joy by connecting to our own feeling of "aliveness" by engaging in a breath-centered yoga practice. The enhanced feeling of vitality that deep, conscious breathing and slow, mindful movement cultivates delivers us to the very essence of being alive in this body.
On those mornings where everything comes together in just the right way in my practice, I'm often overwhelmed with a sense of gratitude for this body, breath and mind that allows me to experience all that life has to offer, whether it's "good" or "bad".
When I touch this deep joy that arises from the heart, I can see that even the hard-to-love stuff is an essential part of this beautiful, crazy life because it helps me appreciate the easy-to-love stuff and not take it for granted, and it helps me take it all with a greater sense of equanimity. The outward expression is that staying connected to joy grounds all my actions and interactions in love and compassion and promotes peace.
When we chant "OM shanti, shanti, shanti", it reminds us that when we connect with our sense of inner peace, it naturally leads to more peace in our relationships with our immediate family and community which leads to a more peaceful world. This is very much the spirit of what Jesus meant when he implored us to love our neighbour as our self. If we're to truly love another we need to first love ourselves, and for that we need to accept and embrace the easily loveable and not-so-easily loveable parts of our self.
So, this holiday season I wish you much Joy and Peace, and may it begin with loving your self.
Om shanti, shanti, shantihi!
— Brian


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WHD Professional Marimba, 4 Octave
WHD Professional Marimba, 4 OctaveDetails
The WHD Professional Marimba offers high quality components and workmanship at a reasonable price. Tuned to 440Hz, and featuring removable African Padauk bars and aluminum resonators, as well as an American Light Oak frame, this instrument has a clear mellow sound, perfect for orchestral playing. A set of high grade beaters is included.
Product Ref: 25968View Full Description
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Warm & Mellow Sound Perfect For Orchestral, Jazz, Rock & Pop
The WHD professional Marimba offers a high quality Marimba at a comparatively low price. With four octaves of Padauk bars ranging from the common C3 to C7, tuned to the UK standard of A=440Hz, over high quality aluminium resonators, this Marimba has a loud warm and mellow sound that is perfectly suited to orchestral playing, as well as being ideal for jazz playing, and even rock and pop.
The removable bars and aluminium resonators are housed in a high quality, solid American Light Oak frame, which not only looks great, but is also lighter than its metal equivalents. This all rests on a strong and durable coated steel body that is on castors with lockable brakes for easy movement and stability when playing. The body is also height adjustable, so players of all heights will be able to find a comfortable playing position.
With these high grade materials, combined with such top quality workmanship, why pay more? The WHD Professional Marimba is ideal for use in orchestras of all sizes, and for any other players looking for a high quality instrument on a budget.
The Latest in Percussion Design, Components and Sound.
WHD is a premium brand of Gear4music.com. Bringing together cutting edge percussion design and premium quality components, WHD instruments have been developed for the percussionist looking to take their sound to the next level. The WHD range includes orchestral percussion, acoustic drum kits, snares and up-to-the-minute electronic drum kits.
Each is constructed using only the finest materials, ranging from specially sourced Birch, Rosewood and American Oak, to super-tough hardened acrylic and quality aluminium. With design features including double braced hardware across the kits and professional REMO heads fitted on all acoustic drums, WHD goes far beyond what is expected from percussion at this price point. Completed by striking visual appeal and stand out tone, WHD are set to establish themselves as the discerning percussionist's choice, whatever style they play.
The product price includes 2 years' warranty and 30 day money back guarantee.
However, the Gear4music extended warranty scheme provides an enhanced service, and is designed to offer a higher level of protection than many 'free' warranties offered by some retailers and manufacturers.
The highlights of this enhanced warranty service are:
- Warranty is extended to 6 years from the date of delivery.
- Our Money Back guarantee is extended from 30 days to 180 days (terms apply after 30 days)
- Collection and delivery costs are included for the first 2 years
- Claim 50% cash back on the cost of the policy after 6 years if it has not been used!
- Warranty is transferable if the item is re-sold
- Loan or replacement equipment will be provided if the product isn't repaired within 30 days
- If an item can not be repaired, a similar alternative product or cash discount (as defined in this policy) will be offered
- The policy can be cancelled within 30 days, and at any time after that for a pro-rata discount
Please note that this extended warranty is currently only available on products sold within the EU or EEA, and is subject to the terms and conditions as detailed on the extended warranty certificate provided.
For customers in outlying areas of the country, the price of the Extended Warranty may be marginally higher, due to the potential for higher collection and redelivery transport costs.
This enhanced warranty is in addition to the standard Gear4music and manufacturer warranty policies, and the Gear4music terms and conditions of trade. No statement or condition of sale contained within these terms affects or restricts your statutory rights as defined under the Consumer Contracts Regulation 2014.
Once the product is delivered, you have 30 days to decide that you definitely want to keep it. If you decide it is not suitable for any reason, you can return it back to us for replacement or full refund, including standard delivery charges.
All Products are new unless stated, and include a minimum of 2 years warranty.
Some items are only eligible for money back guarantee if they are returned to us unused and sealed in the original packaging, and in the case of software, unregistered. These items include:
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We are unable to accept returns of any custom made items designed to work together as a unique package, such as computer system built to a customer's personal specifications. Exceptions may only be possible with prior agreement of the vendor, and may be subject to a cancellation fee.
If you also purchase items that do not qualify for free delivery, some delivery charges may be applied to your order which will be shown in your shopping basket.


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IGP Mediterranee
Mediterranee is an IGP located in the Provencial wine region. It covers over 9,700 hectares in the Alpes de Haute Provence, Hautes-Alpes, Alpes-Maritimes, Ardeche, Bouches-du-Rhone, Drome, Var, Vaucluse, Corse-du-Sud and Upper Corsica. Vines in the Mediterranee IGP benefit from the Mediterranean climate and are planted on extremely diverse soil. The Mediterranee IGP produces both red, white, rose and sparkling wines. The reds develop aromas of fruit, vanilla and grilled notes as well as supple tannins. The whites and rosesare balanced, concentrated, fresh and fruity. Finally, the sparkling wines from the Mediterranean IGP have a beautiful structure, liveliness, and a refined finish.


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"From the director of Fast & Furious" are not words that I want to see in any Star Trek trailer.
Star Trek is a science fiction series. It is at its best when it is exploring the implications of its science. Yes, we want action and adventure, too, but there should be a context: exploration, the conflict between different cultures, the dangers of the (mis)use of technology. The TV series has always been better at this than the films, and perhaps it's understandable that the film would have different priorities in a bid for mass market appeal (though the recent success of the very sci-fi The Martian suggests that there is a healthy appetite for this kind of thing after all). Still, the new trailer looks long on punching, short on thinking.
Trailers can, of course, be completely misleading. I was suckered by the first Terminator Genisys trailer—the good trailer, the one that made the film look like it was going to be an exciting riff on the story we've seen before, not the second spoiler-laden trailer that showed what should have been a major reveal before we even stepped foot in the cinema. So maybe Star Trek Beyond will turn out to be good, but oh boy, the new trailer does not inspire confidence. Star Trek Into Darkness was the worst kind of lazy fan-service, totally squandering the promise of the reboot, but at least it was recognizable as Trek. Based on this glimpse Star Trek Beyond isn't, and it looks like it's going to plumb new depths.


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|Commissioner of Oaths
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Commissioner of Oaths
In terms of section 6 of the Justices of the Peace and Commissioners of Oaths Act No. 16 of 1963, the Minister of Justice and Constitutional Development announced in the Government Gazette on 26 September 2008 that SAIT members holding the membership of Master Tax Practitioner (SA), General Tax Practitioner (SA) and Tax Technician (SA) are Commissioner of Oaths.
View the regulations for administering an oath.
2017-10-18Raft of tax court judgments published on the SARS website consider various interesting issues
2017-10-18WATCH: Drastic increase in taxpayer complaints against SARS
2017-10-18OPINION: Trusts - do they stay or do they go
2017-10-18Dividends tax: The importance of determining when a dividend is "due and payable"


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Merge the best aspects of being a firefighter and circus acrobat with today's Groupon: $20 gets you an introductory pole-dance workout at Sheila Kelley S Factor (a $40 value). Celebrate your assets with the workout routine that celebrity sexpots Teri Hatcher (Desperate Housewives), Allison Janney (The West Wing), and Kate Hudson (Almost Famous) love. Whether you're looking to spicy up your love life or tone up your curves, S Factor will have you arching your back as if you were a sexy long-haired wildcat, not to be confused with the long-eared hedgehog, which is really more cute than sexy.
Harness the power of your curvaceous body to build confidence and muscle tone. Fun and inspirational teachers combine elements of ballet, yoga, and striptease (you won't be shedding clothes at your intro class) to strengthen your core and keep you limber. As the seductress embedded deep within makes her way to the surface, you'll engage rarely used muscles, sometimes resulting in day-after pangs of soreness and a confident saunter.
The warm and cozy S Factor studio in Houston is spacious enough to strut and flaunt with no danger of colliding with a low-hanging stalactite or inconveniently placed fruit cart. S Factor's female-only studios keep the focus on how you take your newly discovered moves back home, to the club, or on a subway platform. It's perfect for a unique girls' day out. Classes are taught seven days a week at a variety of times; check out the class calendar for more info.
Sheila Kelley S Factor
When Sheila Kelley broke into the fitness scene, fitness pole-dancing classes were unheard of. However, in just a few years, S Factor—her unique fusion of yoga, ballet, Pilates, and striptease—became renowned for its physical benefits and confidence-boosting ability. Due to this focus on both mind and body, S Factor garnered widespread acclaim, with endorsements from Oprah, Ellen DeGeneres, and Martha Stewart. The workout's mission is clear: engendering female empowerment, confidence, and respect through sultry pole dancing. S Factor's healthful impact on its students' bodies can be attributed to its combination of diverse workout methods, all of which build lean muscle mass. The course's six levels build on one another, relying on stretches, pole work, and traditional dance to get students twirling around the pole safely regardless of their athletic experience. This movement is designed for a woman's unique body by a woman.


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I can get a little obsessed with organization and over this last weekend I felt like I really needed to take control of my scarf collection.
I looked quit a bit on Pinterest for some ideas but mostly I came up with these strange looking hangers with round shower rings taped to them. I really didn't like that idea because I'm trying to get rid of the bulk my scarfs make in the closet. I had about five each wrapped around a hanger. It was just too much. I was super excited, because it only cost me a little over $10.00, and it took very little time.
My husband and I went to the local Menards and I came up with this instead.
This is a bathroom towel organizer but I added some plain round shower curtain rings and neatly tucked my scarfs away. (next chance I get I'm going to have to organize them by color but I was in a hurry to get dinner started)
At the side of the last bar there are two hooks, so. I was excited to be able to hang up a couple of my favorite hats.
Yippee, for organization!!! I know, the small things make me happy~Bam


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Experience the new and improved BingoTwist
Samsung Galaxy Mega 5.8 smartphone was launched in June 2013. The phone comes with a 5.80-inch touchscreen display with a resolution of 540 pixels by 960 pixels. Samsung Galaxy Mega 5.8 price in India starts from Rs. 19,000.
The Samsung Galaxy Mega 5.8 is powered by 1.4GHz dual-core it comes with 1.5GB of RAM. The phone packs 8GB of internal storage that can be expanded up to 64GB via a microSD card. As far as the cameras are concerned, the Samsung Galaxy Mega 5.8 packs a 8-megapixel primary camera on the rear and a 1.9-megapixel front shooter for selfies.
The Samsung Galaxy Mega 5.8 runs Android 4.2 and is powered by a 2600mAh removable battery. It measures 162.60 x 82.40 x 9.00 (height x width x thickness) and weigh 182.00 grams.
The Samsung Galaxy Mega 5.8 is a dual SIM (GSM and GSM) smartphone that accepts Micro-SIM and Micro-SIM. Connectivity options include Wi-Fi, GPS, Bluetooth and 3G. Sensors on the phone include Compass Magnetometer, Proximity sensor, Accelerometer, Ambient light sensor and Gyroscope.
How to download BingoTwist form Samsung Galaxy Mega 5.8?
- Check the Android version to verify compatibility of BingoTwist with Samsung Galaxy Mega 5.8.
Find Android version: go to "Settings" - "About the phone" - "Android version". Make sure BingoTwist is compatible with Samsung Galaxy Mega 5.8.
- Click the download button to download BingoTwist in Samsung Galaxy Mega 5.8.
- Once the download and installation are complete, find BingoTwist in your home screen and tap the icon to open it.
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|Publication number
|Publication type
|Application number
|Publication date
|Jun 27, 1995
|Filing date
|Jan 19, 1993
|Priority date
|Jun 11, 1988
|Fee status
|Also published as
|Publication number
|Thomas Stief
|Original Assignee
|Behringwerke Aktiengesellschaft
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (4), Non-Patent Citations (16), Referenced by (2), Classifications (24), Legal Events (3)
|External Links: USPTO, USPTO Assignment, Espacenet
This is a continuation of application Ser. No. 07/787,780, filed Jul. 18, 1991, now U.S. Pat. No. 5,376,631, which is a continuation of application Ser. No. 07/364,351, filed Jun. 9, 1989, abandoned.
The invention relates to a process for the preparation of derivatives of fibrin, or fibrin or fibrinogen degradation products or partial sequences, wherein these are treated with an oxidizing agent, products prepared by this process and their use as medicaments or for diagnosis.
Human blood possesses an enzymatic system which is capable of redissolving blood clots which have formed: the fibrinolytic system.
The central enzyme in fibrinolysis, plasmin, is formed from its precursor plasminogen via activators which are liberated from endothelial cells and other cell associations. The activators can be subdivided into two types: on the one hand the plasminogen activators of the tissue type (termed t-PA) and on the other hand the plasminogen activators of the urokinase type (u-PA).
T-PA has a high affinity for fibrin, heparin, and plasmin or BrCN- degradation products of fibrinogen, and its plasminogenolytic activity is stimulated in the presence thereof.
T-PA stimulators of this type are of great interest in the therapeutic and diagnostic respect. They enable considerable dosage reductions in t-PA robe administered and promote a sensitive t-PA detection in plasma. In addition, they allow simple affinity chromatographic purifications of t-PA from biological fluids, for example cell supernatant.
Stimulators such as BrCN-degradation products of fibrinogen can, however, not be employed for therapeutic use because of their high toxicity. In vivo heparin has a low efficiency as a stimulator for t-PA.
Polymorphonuclear leukocytes and macrophages participate in physiological fibrinolysis by secretion of proteinases, inter alia urokinase, collagenase and elastase, and also of oxidation products, in this case in particular N-chloramines.
Surprisingly it has now been found that the oxidation of fibrin and fibrin or fibrinogen degradation products (FDP) caused by N-chloramines, such as chloramine T, leads to a substantial (about 5-fold to 10-fold) improvement in the t-PA-stimulating properties of these products (stimulation of unoxidized FDP=approximately 5-fold and stimulation of oxidized FDP=approximately 25-fold, compared with t-PA without stimulator). It was found that the D region of fibrinogen is the domain responsible for this effect.
The invention therefore relates to derivatives of fibrin, or fibrin or fibrinogen degradation products or partial sequences, wherein all or some of the methionine residues in the basic amino acid sequences have been converted to methionine sulfoxide residues.
The invention also relates to a process for the preparation of derivatives of fibrin, or fibrin or fibrinogen degradation products or partial sequences, which comprises treating fibrin, or fibrin or fibrinogen degradation products or partial sequences, with an oxidizing agent.
The invention also relates to a process wherein fibrinogen or fibrin is treated with an oxidizing agent and the product is degraded. Enzymatic degradation is preferred, specifically, for example, by the action of plasmin, thrombin or batroxobin on oxidized fibrinogen.
Soluble fibrin (so-called fibrin monomers) as starting material is prepared, for example, by incubating 1 mg/ml factor XIII-free fibrinogen, for example F XIII reagent, Behringwerke, in 25 mmol/l Tris, 5 mmol/l CaCl2 and 2 mmol/l Gly-Pro-Arg-Pro, pH 7.8, for 10 minutes at 37� C. with 0.5 IU test thrombin and adding 5 IU hirudin/ml.
Fibrinogen degradation products can be produced in accordance with the process described by Stief et al. (Thromb. Res. 48, 603-609, 1987). A fibrinogen solution (1-10 mg/ml) in 25 mmol/l Tris and 5 mmol/l EDTA, pH 7.8, is degraded by the action of plasmin , preferably by passing the fibrinogen solution through a plasmin sepharose (2.5 mg protein/ml gel) at a flow rate of about 60 ml/h.
The oxidation of the starting materials (=fibrinogen solution or the fibrin monomers or degradation products formed) is carried out at pH 7-9.5, preferably in a buffer, in particular Tris buffer, if appropriate with the addition of 0.01-0.2 and preferably 0.1% (w/v) detergent, such as R Triton�100, and, if appropriate, with the addition of mannitol, preferably 5-20mmol/l, to improve the solubility. The oxidizing agent used is preferably a chloramine, such as chloramine T, specifically in a concentration of 1-20 mmol/l, preferably 5-10 mmol/l. The oxidation can be terminated by adding an excess of reducing agent, such as ascorbic acid, acetylcysteine or acetylmethionine. The oxidation can be carried out at 4-45� C., preferably 20�-40� C., and proceeds within seconds (less than 5 min).
The end products are characterized by amino acid analysis. After protein oxidation, methionine is detected only in traces whereas methionine sulfoxide is detected in amounts which correspond to the methionine content occurring in the protein. The plasmin-degraded and oxidized derivatives also possess a better solubility in distilled water than the unoxidized derivatives.
Synthetic methionine-containing peptides containing sequences from the D-region of fibrinogen are also suitable as starting material for the process according to the invention. Oxidized FDP bind t-PA and sc-uPA (single chain form urokinase) with a higher affinity than unoxidized FDP, as shown in tests with FDP covalently bonded to R Sepharose 4B. For this reason oxidized fibrin and fibrinogen derivatives are particularly suitable for purifying t-PA or sc-uPA (for example from cell supernatants) by affinity chromatography.
Suitable oxidizing agents are, in particular, methionine-specific oxidants, which preferably convert methionine to methionine sulfoxide in an alkali medium, preferably chloramines (for example chloramine T or chloramine B), or salts of hypochlorous acid (for example NaOCl). According to Savige and Fontana (Methods in Enzymology 47: 453-459, 1977), dye (for example methylene blue)-mediated photooxidation and also bromosuccinimide; N-chlorosuccinimide; 2,4,5-tribromo-4-methylcyclohexadienone; BNPS-skatole (2-(2-nitrophenylsulfonyl)-3-methyl-3- bromoindolamine); chloramine T; t-butyl hypochlorite; trichloromethanesulfonyl chloride and also 1-chlorobenzotriazole, iodobenzene dichloride in aqueous pyridine, pyridine bromide complexes, quinolines and, in particular, 1,4-diazobicyclo(2.2.2)octanes in aqueous acetic acid are suitable for the conversion of methionine to methionine sulfoxide.
The oxidation, preferably at pH 8-9, is improved by the addition of 0.05-0.1% detergent, such as R Triton�100.
Oxidized FDP likewise bind to fibrin with a considerably higher affinity than non-oxidized FDP, as can be shown in tests with clotted plasma. For this reason they are particularly suitable for directing substances valuable for thrombus diagnosis and therapy to a clot in vivo.
According to the state of the art, thrombi are detected in vivo using radioactively labeled fibrinogen (Mahn, I., and Muller-Berghaus, G., Haemostatis, 4: 40:50, 1975). Since oxidized FDP possess a considerably higher affinity for the thrombus than fibrinogen, the use of radioactively labeled oxidized FDP, preferably FDP-D, is more advantageous since 1. the clinical findings are available within a shorter time (less than 1 h) after administration of the diagnostic agent and 2. the total organism is subjected to lower radioactive doses since less labeled protein is required because of the high affinity.
On the other hand, according to the state of the art, plasminogen activators (PA) are transported to fibrin clots by using PA covalently bonded to fibrin antibodies or chimeras of PA and fibrin antibodies produced by gene technology.
Disadvantages of these methods lie in the induction of antibodies against the protein foreign to the body. The side effects associated herewith (for example immune complex diseases) can be avoided by the use of human oxidized FDP. HOCl--and chloramine-producing enzymes, such as myeloperoxidase, glucose oxidase and xanthine oxidase can also be transported to a thrombus by means of oxidized FDP if they are in a covalently bonded state with oxidized FDP. The enzyme reaction can be started by infusion of suitable non-toxic substrates (for example glucose, xanthine, hypoxanthine). Oxidation of fibrin polymers in vivo lowers the requirement for endogenous and, if necessary, foreign t-PA to dissolve a thrombus, as a result of which, only small amounts of t-PA have to be administered for a successful lysis. The associated oxidative inactivation of the fibrinolysis inhibitor alpha-2-antiplasmin bonded in the thrombus intensifies the profibrinolytic effects.
In addition, intravenous administration of oxidized FDP gives rise to an intensified generalized stimulation of t-PA and sc-uPA, as a result of which the dose of this PA can be reduced or its use can be dispensed with entirely.
Furthermore, oxidized fibrin(ogen) derivatives are suitable for a sensitive and specific detection of plasminogen activators which can be stimulated, such as t-PA, in in vitro test systems in plasma or other biological fluids. For this purpose, for example, 50-200 μg of oxidized fibrinogen degradation products/ml reaction batch are used in a chromogenic detection method for t-PA together with 3 CTA-U plasminogen and 0.3 μM of a chromogenic plasmin substrate.
Preparation of the oxidized fibrinogen degradation products
a) Plasmin degradation products 250 mg of test fibrinogen (Behringwerke) dissolved in 50 ml of distilled water with 5 mmol/l EDTA were passed through 25 ml plasmin- R Sepharose 4B (2.5 mg plasmin/ml gel) at a flow rate of 60 ml/h at room temperature (RT). The effluent (Eff.) was adjusted to pH 8.5, 12.5 ml of 100 mol/l chloramine T were added and the mixture was incubated for 15 minutes at 37� C. The oxidation batch was then dialyzed (48 h, 4� C.) against the 200--fold volume of 50 mmol/l Tris, pH 8.5.
Alternatively, the oxidized degradation products could be obtained by an oxidation taking place prior to passage through the plasmin-sepharose and subsequent plasmin proteolysis.
b) Thrombin degradation products Thrombin degradation products, according to the invention, of oxidized fibrinogen are obtained by first oxidizing 1 mg/ml fibrinogen with chloramine T at a concentration of 2.5 mmol/l and then incubating with 0.5 IU test thrombin (Behringwerke) for 10 minutes at 37� C. and pH 7.8 and adding 5IU hirudin/ml.
Stimulation of the plasminogenolytic activity of t-PA by FDP as a function of the oxidizing agent concentration--detection of t-PA by oxidized FDP
a) 100 μg of FDP-BrCN (FDP prepared via BrCN degradation) and, respectively, 100 μg of FDP-EDTA (FDP prepared via plasmin degradation in the presence of EDTA) in 100 μl of 50 mmol/l Tris, 100 mmol/l NaCl, 0.01% R Triton �100, pH 8.5, and Tris buffer without FDP were incubated with 50 μl of chloramine T of various concentrations (0-20 mmol/l) in distilled water for 10 min at 37� C. After adding 100 μl of 3mmol/l HD-Nva-CHA-Lys-pNA in distilled water, 200 μl of 1.3 μmol/l Glu-plasminogen in 100mmol/l Tris, 100 mmol/l NaCl, 1% Haemaccel and 0.1% R Triton�100, pH 8.4 (TNHT buffer), and 10 IU two-chain t-PA in 200 μl of TNHT buffer, a further incubation for 12 min at 37� C. took place. The conversion of the substrate was terminated by adding 500 μl of 3.4 mol/l acetic acid and the resulting change in absorption at 405 nm was detected.
b) In a variation, the oxidation of the FDP by addition of 50 μl of 10 mmol/l chloramine T was terminated after 10 min (37� C.) pre-incubation by adding 50 μl of 5 mmol/l dithiotreitol and the plasminogen activation was then carried out.
Result from Example 2 a, b:
TABLE 1______________________________________Fibrinogen degradation productsChloramine T with EDTA(concentra- throughtion in BrCN-de- plasmin-50 μl degraded seph. without FDPaddition) Plasmin activity (A405 nm ; mE)______________________________________0 mmol/l 898 1053 1221 mmol/l 1007 947 1322.5 mmol/l 1067 1310 1345 mmol/l 914 1936 1357.5 mmol/l 728 2218 13610 mmol/l 517 2315 13215 mmol/l 220 2091 11820 mmol/l 138 1900 9810 mmol/l/5 mmol/l DTT 806 2356 129______________________________________
Increasing concentrations of chloramine T lead to an increased capacity for t-PA stimulation. FDP-EDTA and FDP-BrCN show an improvement in their stimulation of t-PA which is only minimal (10%) and is only found at low chloramine T concentration. Higher chloramine T concentrations lead to an impairment in the t-PA stimulation.
Stimulation of the plasminogenolytic activity of t-PA by different FDPs - t-PA detection by FDP
100 μg each of FDP-BrCN, FDP-EDTA, fibrinogen and FDP-EDTA obtained by passing oxidized fibrinogen (see Example 1) through a plasmin-R Sepharose were examined in accordance with the test conditions listed in Example 2a) with the addition of 50 μl of 20 mmol/l chloramine T and distilled water to check their stimulating power towards two-chain t-PA. The oxidation was terminated after 10 min (37� C.) by adding 100 μl of 6.25 mmol/l dithiotreitol and the substrate conversion was terminated after 9 min. (37� C.) by adding 500 μl of 3.4 mol/l acetic acid.
See Table 2 for the result.
In the case of FDP-EDTA, oxidation in the test leads to a pronounced rise in the t-PA-stimulation power. Before oxidation in the assay, FDP-BrCN and FDP-EDTA from preoxidized fibrinogen already possess more than 10 times the stimulation power as compared with the buffer control. The oxidation of fibrinogen also increases its stimulation potential.
TABLE 2______________________________________ 50 μl of 20 mmol/l Distilled water chloramine TStimulant Plasmin activity (A405 nm ; mE)______________________________________FDP-BrCN 443 614FDP-EDTA 276 1172FDP-EDTA 485 962(from pre-oxidizedfibrinogen)Fibrinogen 117 156Buffer control 30 27______________________________________
Affinity chromatographic purification of t-PA and sc-uPA by immobilized oxidized fibrin or fibrinogen degradation products and derivatives
1 ml aliquots of single chain (sc)-t-PA, sc-uPA and two-chain (tc)-uPA (1 μg/ml) in TNHT buffer were incubated for 45 min. at room temperature with, in each case, 0-300 μl of a 50% strength FDP-EDTA solution or oxidized FDP-EDTA-R Sepharose 4B (2 mg protein/ml gel) with a gentle shaking. After centrifugation, the supernatants were removed and tested for their plasminogenolytic activity. The residual activity was expressed in percent of the initial activity. 100 times the amount of TNHT buffer was added to the R Sepharose 4B remaining in the sediment and the whole was mixed thoroughly and centrifuged again. The supernatant was decanted off and 1 ml of eluent was added. 2 M KSCN and 1% sodium dodecyl sulfate were used for this purpose. 10 minutes incubation (RT) with shaking were followed by centrifugation and dialysis (48 h, 4� C.) against 200 times the volume of TNHT buffer. The samples were then tested for their plasminogenolytic activity.
Plasminogenolytic activities were determined by incubating 50 μl of sample (supernatant liquor) with 100 μg of FDP-BrCN, 278 pM of Glu-plasminogen and 0.3 μmol of HD-Nva-CHA-Lys-pNA in a volume of 600 μl for 5 min at 37� C. The conversion of the substrate was terminated by adding 500 μl of 3.4 mol/l acetic acid and the resulting extinction at 405 nm was determined.
Immobilized, oxidized FDP-EDTA show a considerably higher affinity for t-PA than unoxidized FDP. In contrast to u-PA, sc-uPA shows an affinity for bonding to oxidized FDP. The elution of the bound PA molecules can be effected by 2 mol/l KSCN or 1% SDS.
TABLE 3______________________________________ Residual activity in theOxidized (non-oxidized) supernatant liquor50% strength FDP- sc-t-PA sc-u-PA tc-u-PAsepharose (μl) added (%) of the initial activity______________________________________ 0 100 (100) 100 (100) 100 (100) 20 97 (100) 100 (100) 100 (98) 50 85 (100) 94 (100) 100 (100)100 55 (87) 91 (97) 97 (100)200 47 (81) 78 (92) 96 (99)300 31 (47) 55 (90) 90 (96)______________________________________
Separation of the oxidized and non-oxidized fibrinogen degradation products through DEAE-Sephacel and subsequent polyacrylamide gel electrophoresis (PAGE) and assay of stimulation by the individual fragments.
The effluent from the plasmin-sepharose, as indicated in Example 1, was re-dialyzed against 200 times the volume of 10 mmol/l sodium phosphate buffer, pH 8.6. The dialysate was then applied to 100 ml of the DEAE-Sephacel pre-equilibrated with three times the column volume of 10 mmol/l sodium phosphate. Elution (10 mmol/l sodium phosphate, pH 8.6, and 300 mmol/h potassium hydrogen phosphate, pH 4.3, 100 ml in each case) was then carried out at a flow rate of 60 ml/h at room temperature by means of an increasing ionic strength and decreasing pH gradient. 3 ml fractions were collected.
Effluent (before applying of the gradient) and individual peaks were examined with respect to optical density at 280 run and also in sodium dodecylsulfate PAGE (see Tables 4 and 5 for results). Fibrinogen degradation products by plasmin degradation possess the following approximate molecular weights(KDa): fibrinogen 340, X 300, Y 150, D 90, 87, 85, E 60.
TABLE 4______________________________________Non-oxidized starting material Main bands (subsidi- ary bands) in SDSFraction No. OD280 nm gel, unreduced (KDa)______________________________________Effluent 14-29 0.7 90Peak 1 47-50 4.4 90, 85Peak 2 51-54 5.6 90 (300, 60, 150)Peak 3 55-58 0.46 90, 60 (300, 150)Peak 5 83-89 0.3 60, 300 (150)Peak 6 90-98 0.32 60 (300)Peak 7 109-113 0.1 (90, 300)______________________________________
Peak I corresponds to fibrinogen fragment D.
TABLE 5______________________________________Oxidized starting material Main bands (subsidi- ary bands) in SDSFraction No. OD280 nm gel, unreduced (KDa)______________________________________Effluent 12-30 0.34 (90, 60, 150, 300)Peak 1 53-55 0.4 90Peak 2 56-60 0.98 85Peak 3 61-67 2.2 90Peak 4 85-98 0.72 60, 300, 150Peak 5 109-120 0.08 300 (90)______________________________________
Peaks 1-3 correspond to fibrinogen fragment D.
100 μl of the individual fractions from the DEAE separation of unoxidized FDP (EDTA) were examined in accordance With Example 2 for their t-PA-stimulating activity in the unoxidized and oxidized state. See Table 6 for results.
TABLE 6______________________________________ a) distilled b) 20 mmol/l water chloramine TAddition of 50 μl Plasmin activity A405 nm /9 min (mE)______________________________________Effluent (main 184 703band in SDS gel)Peak 1 (FDP-D) 320 1890Peak 2 (FDP-D) 451 1728Peak 3 (FDP-D, E) 583 1145Peak 5 (E, X) 266 223Peak 6 (E) 197 291______________________________________
It is recognized from the measured plasmin activities that the domain of the fibrinogen molecule which is responsible for the stimulation and for the oxidation intensified stimulation is the D region.
Amino acid analysis of oxidized and unoxidized FDP-D
1 mg/ml of fibrinogen degradation product D (peak 1, purified in accordance with Example 5) was incubated in accordance with Example 1 in 50 mmol/l Tris buffer, pH 8.5, with and without the addition of 5 mmol/l chloramine T for 30 min at 37� C. This was followed by dialysis against 100 times the volume of distilled water for 48 h at 4� C. and the use of 1.2 nM protein per analysis in a LKB 4150 amino acid analyzer under varied standard hydrolysis conditions (24 h, 110� C. in vacuo, 3 N p-toluenesulfonic acid). The results are mean values of triple determinations. The amino acid tryptophan could not be determined under the conditions used (Table 7).
TABLE 7______________________________________Amino acid composition D (%) oxid. D (%)______________________________________Asp 13.2 12.5Thr 4.0 4.3Ser 5.8 6.1Glu 10.3 12.4Pro 4.9 5.6Gly 11.6 12.2Ala 4.7 4.5Cys 0.4 0.4Val 3.9 4.4Met 0.8 <0.1Ile 3.3 3.5Leu 5.3 5.6Tyr 2.8 2.4Phe 3.1 3.0His 3.2 3.3Lys 8.4 8.2Arg 6.3 6.9______________________________________
The two proteins differ essentially in the lack of methionine in oxidized D. Methionine sulfoxide migrates in the analyzer to another site and is not indicated as methionine.
Increased affinity for fibrin thrombi of oxidized FDP compared with unoxidized FDP: detection of thrombi
0.5 ml of plasma was clotted by adding 50 μl of 0.2 mol/l CaCl2 and 0.5 IU of thrombin. The resulting clots were then washed by centrifuging three times in 20 times the amount of phosphate buffered saline (PBS) and incubated for one hour at room temperature in, in each case, a PBS solution of 0.5 ml of oxizided FDP (FDP=plasmin degradation of fibrinogen in the presence of 5 mmol/l EDTA) (1 mg/ml) and 0.5 ml of unoxidized FDP (1 mg/ml) or, respectively, 0.5 ml of fibrinogen (1 mg/ml) (control=FDP solutions without clots). Subsequently the residual stimulation power of the FDP in the supernatant liquor was tested by incubating 50 μl of a tissue plasminogen activator solution (500 IU tc-t-PA/ml) in PBS with 100 μl of supernatant liquor, 200 μl of plasminogen (=1 CTA-U in 100 mmol/l Tris, 100 mmol/l NaCl 1% (w/v) R Haemaccel, 0.1% (w/v) R Triton�100, pH 8.4) and 100 μl of 3mmol/l D-norvalyl-cyclohexyl-alanyl-lysyl-paranitroanilide (HD-Nva-CHA-Lys-pNA) in distilled water for 8 min at 37� C., stopping with 500 μl of 8.5 mol/l acetic acid and determining the extinction at 405 nm.
See Table 8 for result.
TABLE 8______________________________________ Plasmin activity (t-PA)Sample = stimulus A405 nm /8 min t-PA stimulation(1-3) (mU) power*______________________________________Without clots:1 oxid. FDP 1,235 + 14 15.42 unoxid. FDP 587 + 6 7.33 Fibrinogen 216 + 1 2.7With clots:1 oxid. FDP 755 + 4 61%**2 unoxid. FDP 465 + 1 80%3 Fibrinogen 171 + 2 80%Control (stimulus) 80 � 3percentage______________________________________ *Ratio of tPA activity with stimulus: tPA activity without stimulus **in % without clots
It can be seen that the greatest decrease an the t-PA stimulation power of the supernatant liquor occurs with oxidized FDP, which means that oxidized FDP has a higher binding affinity to fibrin than unoxidized FDP or fibrinogen.
Oxidation of fibrin monomers leads to an intensification of their stimulation properties towards t-PA
100 μl (1 mg/ml) of fibrin monomers in buffer were incubated with chloramine T of different concentrations for 10 min. at 37� C. The oxidation was then terminated by adding 100 μl of mmol/l N-acetyl-methionine, pH 8.4, and
200 μl of tc-t-PA (=10 IU) in buffer , 200 μl of plasminogen (1 CTA-U) in buffer and 100 μl of 3 mmol/l HD-Nva-CHA-Lys-pNA in distilled water were added and the mixtures incubated for 24 min. at 37� C.
The substrate conversion was terminated by adding 500 μl of 8.5 mol/l acetic acid and the resulting extinction at 405 nm was determined.
TABLE 9______________________________________Result:Chloramine T addition Plasmin activity (mA)(50 μl) (mmol/l) fibrin monomers buffer______________________________________ 0 1274 + 5 244 + 3 1 551 + 5 5 795 + 1110 2095 + 4520 2287 + 440 2276 + 4 248 + 8______________________________________
It can be seen that increasing concentrations of chloramine after an initial decrease subsequently leads to an increase in the t-PA stimulation. Addition of methionine does not impair the measurement method, as can be shown in the buffer control.
|Cited Patent
|Filing date
|Publication date
|Oct 11, 1974
|Sep 7, 1976
|Pierce Chemical Company
|Radioactive compounds for labeling proteins
|Apr 2, 1981
|Jan 24, 1984
|Research Corporation
|Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo
|Apr 2, 1981
|Jun 19, 1984
|Research Corporation
|Inhibition of fibrin polymerization by a peptide isolated from fibrin Fragment D1
|Jul 1, 1988
|Oct 15, 1991
|Behringwerke Aktiengesellschaft
|Method for the determination of the activity of serine proteases or serine protease inhibitors
|Ardaillou et al., Biol. Abstracts, vol. 72:8464, 1981.
|B. Chibber et al., "Effects of Human Fibrinogen and Its Cleavage Products on Activation of Human Plasminogen by Streptokinase," Biochemistry, vol. 24, No. 14, Jul. 1985, pp. 3429-3434.
|B. Chibber et al., Effects of Human Fibrinogen and Its Cleavage Products on Activation of Human Plasminogen by Streptokinase, Biochemistry, vol. 24, No. 14, Jul. 1985, pp. 3429 3434.
|Haemostasis, vol. 4, pp. 40 50, 1975, Mahn and Muller Berghaus, Studies on Catabolism of 125 I labelled Fibrinogen in Normal Rabbits and in Rabbits With Indwelling Intravenous Catheters: Methodologic Aspects .
|Haemostasis, vol. 4, pp. 40-50, 1975, Mahn and Muller-Berghaus, "Studies on Catabolism of 125 I-labelled Fibrinogen in Normal Rabbits and in Rabbits With Indwelling Intravenous Catheters: Methodologic Aspects".
|Inada et al., Biochem. Biophys Acta, 532 (1978) pp. 161 170.
|Inada et al., Biochem. Biophys Acta, 532 (1978) pp. 161-170.
|Mello Perisse et al., Chem. Abstracts, vol. 82:167068h (1982).
|Methods in Enzymology, vol. 47, pp. 453 459, 1977, Savige and Fontana, Interconversion of Methionine and Methionine Sulfoxide .
|Methods in Enzymology, vol. 47, pp. 453-459, 1977, Savige and Fontana, "Interconversion of Methionine and Methionine Sulfoxide".
|Shechter et al., Biochemistry, vol. 14, No. 20 (1975) pp. 4497 4503.
|Shechter et al., Biochemistry, vol. 14, No. 20 (1975) pp. 4497-4503.
|Thrombosis Research, vol. 48, pp. 603 609, 1987, Stief, et al., A Simple Method for Producing Degradation Products of Fibrinogen by an Insoluble Derivative of Plasmin .
|Thrombosis Research, vol. 48, pp. 603-609, 1987, Stief, et al., "A Simple Method for Producing Degradation Products of Fibrinogen by an Insoluble Derivative of Plasmin".
|Tietz, N. W., "Fundamentals of Clinical Chemistry," 1976, pp. 286-288.
|Tietz, N. W., Fundamentals of Clinical Chemistry, 1976, pp. 286 288.
|Citing Patent
|Filing date
|Publication date
|May 26, 1995
|Apr 14, 1998
|Bristol-Myers Squibb Company
|Fibrin sealant compositions
|May 31, 1995
|Oct 5, 1999
|Bristol-Myers Squibb Company
|Solid compositions of fibrin monomer
|U.S. Classification
|435/13, 530/382, 210/656, 435/212, 435/217
|International Classification
|Cooperative Classification
|European Classification
|Jan 19, 1999
|Maintenance fee reminder mailed
|Jun 27, 1999
|Lapse for failure to pay maintenance fees
|Sep 21, 1999
|Expired due to failure to pay maintenance fee
Effective date: 19990627


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Located in the Brazeau River Valley at the head of McDonald Creek. Park, Alberta Major headwater Saskatchewan River.
Latitude 52; 21 Longitude 116; 57, Topo map 83C/07
Named in 1935. McDonald, Angus (Angus McDonald was the son of Archibald McDonald and Jane Klyne (Cline). He worked with the Hudson's Bay Company.) Official name.


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Contact Info / Websites
All 9 game Reviews
Battle Gear 2
Rated 5 / 5 stars
This is really awesome. :D Even though I had no clue of what I was doing. xD
The game is well designed as well. I hope this get's a good score!
Kanye vs Taylor
Rated 3 / 5 stars
To be honest, this reminded me of one of those "shoot the ducks to win a prize" advertisement games. It's still pretty decent though.
Thanks wolf. Yeah I just wanted to make a funny little game that's kind of cathartic for those of us who felt bad for Taylor. It's a funny situation all around and I wanted to capture it in a game.
Perfect Fart
Rated 2.5 / 5 stars
This game wasn't really that interesting at all to me. The graphics were good but the whole point of waiting for 5 seconds for a fart isn't really that fun.
Rock Paper Dropkick
Rated 4 / 5 stars
Pretty good.
I found this game to be quite entertaining.
The problem is that the controls were placed kinda awkwardly for me. Other than that I had no other complaints. :)
Rated 4.5 / 5 stars
Pretty cool!
I thought this game was really awesome and well made. :)
xD Even though my mouse is a bit broken I still had fun playing this.
New Super Paper Pong
Rated 4.5 / 5 stars
Well done. :)
For just a simple game of pong, this is actually well made.
Nice job on making this. :D
Jungle Magic
Rated 5 / 5 stars
The design of this game is really well done. Seems like you really took your time into this project.
Completely amazing.
Thanks! :)
Hover Bot Arena 2
Rated 5 / 5 stars
Completely awesome
After playing this game for a few minutes I found myself enjoying the game REALLY well.
Even though it has a the same concept of most shooting/arena games, to me it has a distinct feel to it.
Awesome job on creating this. I look forward to more in the future.
Dig Defense
Rated 3 / 5 stars
Eh..It's ok.
The game is ok in general but as someone stated before, this game is basically a copy of Ballon Tower. But it's a good start though.


text:
|Reviews for from order, chaos
| JPElles chapter 1 . 3/21/2016
Great story. Interesting stuff. Glad I found and read this even if you won't update it further.
| Kurai Ummei chapter 1 . 11/19/2015
| super-rat chapter 1 . 6/1/2015
This is a delightful read!
I'm going to go read the sequel now...
Thanks for posting this!
| SIM99 chapter 1 . 10/18/2013
This was fantastic! Especially the end, it was absolutely perfect. Heck, I made a quote section on my profile JUST for when Hades said, "It's called the divine spark, not the divine fireball of death." I laughed quite a bit at that.
| The-Fun-In-Funeral chapter 1 . 10/9/2013
Intriguing, most definitely. I saw the sequel in the archive, but it seems so short :( Oh well, I look forward to reading it anyway :) This was well written, and certainly interesting. Nice to see a little more historical accuracy than the movie had. Zeus? Nice? Ha! As if, the jerk... Anyhoo, I'll be off to read that sequel now :)
| Niamh St. George chapter 1 . 7/31/2013
Oh, this was GREAT. A fantastic look inside Hades' head, and entirely workable as an AU of the Disney AU. I like, too, that you pulled what you could of the original myth into the story. Also the subtleties of the Hades-and-Meg of it worked really well, too. LOVED IT LOVED IT LOVED IT.
| Lita Snow chapter 1 . 2/16/2013
This is soooo awesome, seriously! Please tell me there's a continuation for this, it can't be over! I love the story and want to see more!
| therentyoupay chapter 1 . 11/20/2012
Perfect, perfect, perfect.
| elfenwindakachrno chapter 1 . 5/8/2012
I love this story SOOOO much!
It's great! And i really like your hints towards greek mythology!
i wish you could write the actual journey of them! it would be wonderful!
| redwingsgirl514 chapter 1 . 1/17/2012
So, there going to be any more? You've got me hooked. :)
| narutolover1996 chapter 1 . 11/9/2011
you should make a sequal
| neverest chapter 1 . 10/17/2011
aww..that was sweet :o)
| Strify chapter 1 . 9/1/2011
I hsve to say...I love this fic. i imagined Meg sarcastic, more world-weary and tinged with sadness but still with the same spark. Without a doubt you wrote her really well. And Hades, less outrageous, probably thanks to being dumped in the pool of souls and all, but with his character intact...The plot is very interesting and I sincerely hope to see it continue. I root for Meg all the way in her journey...
| MegaPotterGleek chapter 1 . 8/13/2011
That was so fantastic. It was exactly the kind of Meg/Hades fic I was looking for. Your characters were written so well I could here their voices in my head saying your words. And it was sort of sad, but not too sad. And there were the hints of romance, but not to the point where it was overwhelming. It was just so awesome, I can't even get over it. Just fantastic. Loved it.
| emi-chan chapter 1 . 8/9/2011
Wow! What an awesome story. Absolutely loved it! You did such a good job with the writing and the characters that I actually heard the movie voice actors while I was reading the dialogue. That very rarely happens! It would be worth the time to invest more in continuing this story!


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panner46 Review
Loved It
The best part was how easy it was to put together.
- How did the color on site compare with the actual product? Great
- Please tell us about the quality of the product. Excellent
- How accurate was the on site description of the product? Right on.
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"Cities are getting bigger as more and more people move in, and there will always be a needs for house with respect to general quality of life."
– Alan Dundes
Although situated in a dense urban area, a house still has to be a comfortable nest, protecting occupants, make everyone feel closer in harmony, and most importantly, a sense of 'at home' in the house, so that every occupant spends every second of their precious time to be with family at home in the midst of urban activity.
In response of the characters above, split level was used as a design solution to create the impression of widespread room, added with natural touch such as fish pond and greenwall on the main staircase.
Address : Sunter Griya Inti Sentosa, Jakarta
Category : Residence
Building Area : 500 m2
Land Area : 325 m2
Year of Project : 2010
Architects : Rudy Kelana, Matheus Sompotan & Paula Silalahi


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Council To Continue Support Of Mainstreet Program
Council To Continue Support Of Mainstreet Programme
Auckland city's Strategy and Governance committee has recommended that the council continue its direct financial contribution to the Mainstreet programmes.
Committee chairperson, Councillor Mark Donnelly says Mainstreet is a valued project, producing worthwhile benefits for businesses operating in the 15 Mainstreet areas, and also for the wider communities serviced by those areas. He said that a recent round of consultation with the Mainstreet groups had been constructive, highlighting opportunities to reduce costs and to make the programme more effective.
Mainstreet programmes are a partnership between the council, the business communities, and the wider community, around defined "mainstreet" areas. There are currently 15 programmes of varying size and complexity, operating in Avondale, Blockhouse Bay, Eden Valley, Ellerslie, Glenn Innes, Heart of the City (CBD), Karangahape Road, Mt Eden Village, Newmarket, Onehunga, Otahuhu, Panmure, Parnell, Remuera, and St Heliers.
The programmes are funded mainly through rates from within the defined areas, and provide a focal point for efforts to enhance and develop these traditional neighbourhood shopping centres. Basic objectives are to enhance physical environments, promote business creation and development, increased employment, and local business investment. Community development and heritage conservation are also objectives.
A steering group consisting of Mainstreet
representatives, council officers and Councillor Donnelly,
is to be set up and will work closely to review the current
structure and operation of the Mainstreet programme.
The committee recommended a reduction in the Mainstreet budget of $50,000. Councillor Donnelly says he expects that this collaborative review process will identify efficiency gains and improvements to the current arrangements, making the lower target attainable.
An earlier proposal that council recover the cost of its annual contribution from Mainstreet business ratepayers is to be deferred for a year, giving the steering group a chance to complete its review of the current programmes. Councillor Donnelly says the committee recognises the importance of continuing to expand the Mainstreet programme, enabling other areas around the city to become involved.
The Combined Committees of council will consider the Strategy and Governance committee's recommendations when it meets later this month.


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Varieties of wheat designated as the class Canada Western Amber Durum (CWAD)
Order number 2017-40 - Variety designation list
July 31, 2017
List of varieties designated as the class Canada Western Amber Durum (CWAD)
Pursuant to the definition of "class" contained in section 2 of the Canada Grain Act, the Commission establishes the class Canada Western Amber Durum (CWAD) and designates the varieties of wheat listed below as the class.
- AAC Cabri
- AAC Current
- AAC Congress
- AAC Raymore
- AAC Marchwell
- AAC Durafield
- AAC Spitfire
- AAC Stronghold
- AC Avonlea
- AC Melita
- AC Morse
- AC Navigator
- Brigade
- CDC Alloy
- CDC Carbide
- CDC Credence
- CDC Desire
- CDC Dynamic
- CDC Fortitude
- CDC Precision
- CDC Verona
- CDC Vivid
- Commander
- Eurostar
- Enterprise
- Kyle
- Napoleon
- Strongfield
- Transcend (formerly DT801)
- Wakooma
- Wascana
This order will be in effect for the crop year commencing August 1, 2017 and continuing until July 31, 2018, unless revoked earlier.
Doug Chorney
Assistant Chief Commissioner
Lonny McKague
In accordance with Section 28 of the Canada Grain Act, varieties not designated by the Canadian Grain Commission to a specific class or varieties which are not a registered variety under the Seeds Act will only be eligible for the lowest grade for that kind of grain.
- Date modified:


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Clapton is God 20:42 23 Jan 2008
The section is particularly awful in rush hour.
The times to avoid, ideally, are any time between 1st January and 31st December each year.
To give an example, I started a new job in September 2007 which required me to use the M25 between the M23 (junction 7; not 8 as you state) and junction 9 (Leatherhead).
In my first 5 working days (10 journeys); what should have been a door-to-door journey each way of 35 minutes, took me 10 different times varying between 35 minutes (just one journey) and 80 minutes!