text:
Hi All,
We are considering making some improvements to Orion's log management capabilities. We'd really like to hear how members of the Thwack community are managing log data in your environments and are therefore running a Log Management Survey and would really appreciate your response. It takes <5 minutes and upon completion you will be entered into a draw with a chance to win one of ten $50 Amazon® gift cards*.
Survey Link - SolarWinds Log Management Survey
Also, I'm very interested in talking to users about their current log management practices, so if anyone is up for a quick discussion, please send me a direct message.
Thank you!
*Terms & Conditions available here.
First off, I'd like to personally welcome you to THWACK. I'll start off with a brief introduction of who we are then we'll jump right in.
Maybe you've heard rumblings of thwack or perhaps this is your first time hearing of us. Whichever the case may be, I'm sure there is one question that stands out in your mind; What is thwack and why does it benefit me? Simply put, THWACK connects you with more than 130,000 community members who have contributed to help us make superior products, provide educational IT content, and most importantly, help IT professionals do their jobs better. Here we put you in direct contact with the people who manage and develop our products, here is where you have a say in the direction of our products, and here is where you get support and answers on the fly without having to pick up the phone. Crazy, huh? A company that actually listens to their customers. And you're just now getting here! Without further ado, allow me to show you what you've been missing.
With almost 10 years of content, thwack can appear daunting to a first-comer. To ease the learning curve, we're going quickly to guide you through some of the most important pieces of the site. Along the way you'll earn points and a bonus 500 points for completing the mission. You do not need to complete these tasks in one sitting. Feel free to come back at your convenience.
Have a customer portal account? Link your THWACK & Customer portal accounts to earn an additional 2,000 THWACK points! Plus you'll get great benefits like seeing the products you own on your THWACK profile, see your renewal dates, renew licenses, open support tickets, review existing support tickets, & gain more visibility and access to beta's for the products you own.
No, we won't spam your inbox or add you to any marketing list. Having an account simply allows you to contribute and take advantage of all the features on the site. This should take less than a 5 minutes of your time. To create an account, find the "Register" link on the top right hand corner of your screen. If you already have a THWACK account, you do not need to create another one. You will need to be logged in in order to complete the rest of the tasks.
Here on thwack, you'll find thousands of downloadable templates, reports, scripts and more that allow you to customize and extend our products. Some content in this area is created by SW employees and the rest has been created and shared with the community by our members.
For this task, navigate to the Content Exchange. To get there, you first need to go to the Product Forums button in the top navigation bar, choose the product that you're familiar with, and then feel free to pick a section of content that suits your needs. From there, browse through the documents until you find something that sparks interest.
Next, download the template, report, script, etc. that you've chosen. You can then plug this item into the product which ultimately extends the functionality that is provided out-of-the-box (plugging the downloaded item into the product is not required to complete this task - however, we do recommend you check it out when time becomes available).
As mentioned earlier, we greatly value customer input and will gladly review requests for new features. Here on thwack you can submit an idea or feature request for future implementation. Product Managers pay special attention to this concept of "ideation" and to gauge interest, we allow community members to vote on feature requests. Let me quickly explain how the process works before I give you the task at hand. There are 5 stages in which an idea can be slated for. When a user creates an idea, it is placed into the "Recent" stage. The Product Manager then reviews the request and will move the idea into 1 of 3 stages - Open for Voting, What We're Working On, or Closed. If an idea is placed in the "Closed" stage, it means the request is either unfeasible or doesn't fit with the direction of the product. The last stage is "Implemented" which means the feature has been added to the product. You can read more here about the recent features that were added to our products because of the crowd-sourcing feature on thwack.
For this task, navigate to a product feature request forum. Choose a product you are familiar with from the Product Forums in the top navigation bar, and then click on Feature requests.
You'll then be dropped on a page which showcases the "top ideas" for that product (choose "show all" at the bottom of the list to see all ideas). Find a feature request that would bring value to your environment and vote for it.
The product forums are where you will get most of your support, from either other community members or a SolarWinds employee. There are developers, product managers, community staff, and others that are here to answer your questions and help resolve issues.
For this task, navigate to a product forum. There is a shortcut to this area at the top of your screen, look for the tab that reads "Product Forums". Choose a product you are familiar within the drop-down menu, then click on Content. There is an exceptional amount of content in most of our forums so please take a minute to click around.
Find a discussion thread that sparks your interest and "like" it.
You can find the "What We're Working On" in the global navigation, look for "Blogs & Groups", then "Announcements", and you'll see it in the Featured Content. This post stands as a guide to what the teams are working on for each of our products. Once you've found the guide, bookmark it.
Bookmarking a piece of content will place it in your bookmarks.
We have several blogging areas here on thwack, 6 to be exact. For this task, let's focus on 2 specific blogging areas: Product Blog and Geek Speak.
First, navigate to the Product Blog. You can get there by clicking on Product Forums in the top navigation bar, pick a product, and then go to Product Blog. Some of these blogs may look familiar because they're actually streamed into our products, but I'll bet you didn't know they came from thwack. Click on a blog that interests you and take a minute to read. Make sure you click on the blog subject line for the action to be recorded.
Second, navigate to Geek Speak. To get there, go to the Geek Speak featured content further down on the homepage.
Choose a blog that interests you and take a minute to read. Make sure you click on the blog subject line for the action to be recorded.
You want to see which tasks you still need to complete? No problem! Go to your Profile - More - Reputation - Missions, and just look for this particular mission. Once you click on the wheel in right corner, you'll be able to track your progress, based on the bars displayed in the same order as listed in the onboarding mission. Depending on the completion of a certain task, you'll see either a blue bar (complete) or a white bar (to complete).
That's it! You've completed your first mission and earned 1500 points to be used in the thwack Store! Below are a few other good resources to check out. If you have questions on anything thwack, feel free to reach out to myself or wabbott .
Young THWACK®-hoppers, your monthly mission is complete.
You now have the skills you need to master the art of Security Kung Fu.
We hope you take the wisdom from this journey to help you defeat any cyber security threats that may lie ahead.
Mission Recap Survey & Questions:
Content Resources:
Log & Event Manager
A SIEM that makes it easy to use logs for security, compliance, and troubleshooting
Grand PrizeOctober 30: Xbox One X
Performance Hog: He's the process that just keeps consuming. Yeah, he's that guy that will take the last chicken wing off your plate and say "you weren't going to eat that were you?" This would be the SQL statement you see consistently popping up as the most impactful in the charts. Think of a select with numerous joins without a where clause (nothing to filter by).
Query Blocker: He's the guy with the broken down 1984 lemon in your lane! Your stuck. You are going to be late for work. Look for the SQL transaction in your database that doesn't commit or rollback – yeah, that's the guy. He causes all kinds of blocking waits. He may even have rolled an external dependency into the transaction.
Blame Shifter: He's subtle. He makes his appearance when applications slow down, but no one knows what the issue is. This when everyone starts pointing fingers! No one wins the blame game, except Blame Shifter. Is it the query itself? Is it the database configuration? Is it the data model? Is it the infrastructure? Where do you even begin?!
Submit a screenshot of your chosen view
|Weekly Prizes
Correctly answer all 20 questions by October 29 and get entered to win the Grand Prize! Xbox One X - release date 11/7
Monthly Mission Terms and Conditions: US, UK, and Canada | Germany | Australia
Mission Shortcut Terms and Conditions: US, UK, and Canada | Germany | Australia
Start the SolarWinds Network Management Assessment to help you assess your current network monitoring and management challenges across the three dimensions of Coverage, Tools, and Measurement.
Then compare your results to your industry peers, and get some recommendation advice to help address any identified shortcomings.
Curious to learn about Patch Manager? This new SolarWinds Academy course is a great primer and will get you up to speed quickly.
*NOTE: Attending the training will earn you 2,000 THWACK points!
Please register to attend the live training from the SolarWinds Academy!
Title: Introduction to Patch Manager
Link: https://customerportal.solarwinds.com/VirtualClassrooms/#121
Specifically, this training will cover:
How to register: To register your attendance for this class please log into the customer portal and select the appropriate class and date to register. https://customerportal.solarwinds.com/VirtualClassrooms/#121
Curious to learn about what's new in the NPM 12.2 release, including PERFSTACK?
Please register to attend the live trainings from the SolarWinds Academy!
*NOTE: Attending these trainings will earn you 1,000 THWACK points!
Title: New Feature Training: NPM 12.2 AND Perfstack
Link: https://customerportal.solarwinds.com/VirtualClassrooms/
Specifically, this training will cover:
- Network Insight for Cisco ASA
- Updates to the install/upgrade process
- Database connection and security enhancements
- PerfStack, including Real Time monitoring capabilities
- ARM/Linux Agent
- User Interface Updates
- Additional ASA support in NCM and UDT
- Where to find upgrade resources including guides, training videos and release notes
How to register: To register your attendance for this class, please log into the customer portal and select the appropriate class and date to register. https://customerportal.solarwinds.com/VirtualClassrooms/
Hello THWACK Community! My name is Brett and I am a new Community Manager here at Solarwinds in Lehi, Utah! I am SO excited to meet everyone in this great community!
Just a bit about myself… I am originally from Northridge, CA. I attended junior college in Santa Monica, CA and then graduated from Arizona State University at the Walter Cronkite School of Journalism and Mass Communications in August 2015.
I have found my passion in building online communities and serving people within these communities.
Outside of THWACK, I enjoy traveling, meeting new people, being around water, spending time with my girlfriend (VERY soon to be fiancé!), college football, and trying new restaurants!
In regards to THWACK, I'm here to serve you and continue to bring an excellent user experience! But first, I want to hear from YOU!
What are your favorite aspects of THWACK? How can I help you?
I look forward to interacting with everyone here in this wonderful community! And don't hesitate to reach out with any questions/comments/funny memes!
This week, we are hosting a webcast called Five Ways to Reduce Your Network Config Management Stress. This is for all of you who are trying to manage one hundred things all at once. Our presenters, SolarWinds Head Geek™, Destiny Bertucci ( Dez ), and SolarWinds Principal Product Manager, Tyler Peterson (tyler.peterson), will go over five easy ways to simplify network configuration management so you can get time back in your day. Register HERE.
Webcast: Five Ways to Reduce Your Network Config Management Stress
Date: Thursday, September 14, 2017
Time: 12:00 p.m. CDT
Duration: 50 minutes plus live Q&A
Helpdesk ticket #8675309
Report date: 8/7/17 8:00 AM
Est Due date: 9/3/17 11:59 PM
Department: Marketing (again)
Status: Closed!
Request type: Helpdesk request > Hardware
Subject: Sending out an S.O.S. (Save our server)
Notes: Congrats THWACKsters! You were able to successfully rescue your end-users from the clutches of downtime, password, resets and most importantly from id10T errors.
Mission recap survey & questions:
Web Help Desk
Grand PrizeOctober 2: PS4 + Kung Fu Panda Game
|Weekly Prizes
Correctly answer all 20 questions by October 1 and get entered to win the Grand Prize! PS4 + Kung Fu Panda Game
Monthly Mission Terms and Conditions: US, UK, and Canada | Germany | Australia
Mission Shortcut Terms and Conditions: US, UK, and Canada | Germany
It is with great sadness that I share with y'all today that I am officially leaving THWACK. This was a tough decision to make as I have truly loved being apart of such a passionate and dedicated community, but the time has come for me to close this amazing chapter of my life. I am so thankful that this was my first job opportunity after graduating college and will forever remember each and everyone of you and your love for all things THWACK!
I have to give a huge shout out to my team members DanielleH, wabbott, and thegreateebzies. Y'all made it easy to come to work everyday and always kept me laughing and smiling. I hope my next set of coworkers enjoys how much I talk about Weezer (my cat) and can handle my love for food--especially doughnuts and queso.
It's been a wonderful and I can't wait to see where my life takes me next!
To all the people I met here at SolarWinds,
Attention everyone who lives in the U.K. or Germany - SolarWinds is bringing a SolarWinds User Group (SWUG) your way soon! We had an amazing time with those of you who attended the London SWUG last year and we're coming back in full-force later this year. SWUG is also looking to make a stop in Germany for our first time.
Registration for London is now open: November 14, 2017 - London, U.K. SWUG
Registration for Berlin is now open: November 10, 2017 - Berlin, DE SWUG
Have you had success with Database Performance Analyzer? Do you love DPA? Are you interested in sharing your story with us and others? Could you potentially act as a SolarWinds reference?
If you don't mind, please take a minute, (and grab a quick 500 THWACK points), to complete a quick survey and let's start the conversation! We look forward to your feedback.
Thank you!
*Points will be applied when survey closes.


text:
Two persons have been confirmed dead and several others critically injured in an electrical surge in Anguwan Biri in Bosso Local Government Area of Niger State.
Ibrahim Inga, Director-General of the State Emergency Management Agency, NSEMA, told the News Agency of Nigeria in Minna on Sunday that the incident occurred on Saturday as a result of a power surge resulting from contact between a 33KV line and distribution line in the area.
He said that a middle-aged man, Mohammed Tetengi, and an 8-year-old, Ayomide Michael, died in the incident and several people sustained various degrees of injuries.
Mr. Inga said that three persons were currently receiving treatment at the Minna General Hospital.
He said that officials of the agency have visited the scene to conduct an assessment on the level of damage, adding that the remains of the victims have been buried according to Christian and Islamic rites.
Bala Elkanah, the Police Public Relation Officer in Niger, said that properties worth millions of Naira were destroyed in the incident.
He gave assurance that investigation would be carried out to determine the actual cause of the incident.

subset: commoncrawl


text:
1100 13th Street, NW, Suite 750Washington, DC 20005202.887.6400Toll-free: 800.544.0155
All Contents © 2017The Kiplinger Washington Editors
If you're buying a used vehicle in an area recently hit by a hurricane, check to make sure it doesn't have any flood damage.
Perhaps the first frost has already coated your windshield, forcing you to dig out the scraper. As you adjust to the chill, give a thought to your ride, ...
See All Slide Shows »
See All Practical Advice From Our Partners »


text:
With falling branches and trees hurting or killing 12 people in the last two months in New York City, questions are being raised about just how many more dangerous trees are lurking in the city's parks. Brynn Gingras reports.
Published at 6:42 AM EST on Aug 6, 2013 | Updated at 8:57 AM EST on Aug 6, 2013


text:
Waterloo Road in Hillside, Southport is getting a new road surface dressing this week (Mon-Fri 20th-24th August 2012).
Bitumen emulsion is sprayed onto the road using a large spray tanker, chippings are then spread over the bitumen using a self propelled chipping spreader followed behind by a spray tanker.
The chippings are then compacted into the bitumen by two or more rollers following closely behind.
Residents are asked not to park their vehicles on the road or verge when work starts.
Onthespot – your online reporter
Do you have a story to tell? Please text or phone 07930717137 or email firstname.lastname@example.com
Follow OTS (Onthespot) on Twitter www.twitter.com/onthespot_news


text:
If you are looking for a real, real gain muscle, then you are definitely in the right place. If you really want to gain muscle there is one thing you must understand: Learning to build muscle is very simple. In fact building muscle is hard (for most people). This is because many people are afraid of one thing ... work. Read on to know how to get explosive results with the direction of the truth about muscle gain.
Guide actually gain muscle - Is this useful?
In short, I'd say it's worth. Indeed, Sean Nalewanyj continues to build muscle as it should be ... easy. You see, many people overload of information about the search for a training program to follow. This is because large amounts of bull out there on the subject. That's true muscle gain? The truth is that only you can understand.
His body is made differently from the way Sean, so that your program does not work, as it did for him to do it for you. But, if you decide to jump into this program, here are some tips for success ...
1st Tunnel Vision
This is very important. I mentioned above that there is a lot of information "less than stellar" about building muscle. The problem is that a lot of guys to deviate from this information. Authorized disrupt thousands of techniques that exist.
You need to keep your focus. You must realize that you have the knowledge to gain muscle you want. Now it's just a matter of working with perseverance. Do not be distracted with all the different techniques and programs out there. He did not have time to try them all, even if you tried.
2. Plan your meals
If you're a hard gainer like me, you should know that your diet is essential to get the results you want. Adhesive meal plans and have a uniform when you eat every meal schedules. No joke, every meal is important to your success.
Muscle gain truth to do good for you. Just follow these steps and you're ready.
You must have a burning passion to reach their ideal body type. If you do not have that passion, I suggest you grow. How did you feel when you have this exact body of your desire? Visualize. Take the time to feel the passion and excitement in the gut. It is made stronger. It feels good, does not it? This level of passion is what makes dreams a reality. Care must be taken before you can provide significant value to everything else in life.
If you have the desire, then you ripped, toned, sexy body you've always wanted. It takes a lot less time than you think. If you are looking for 100% impartial investigation of all effective muscle building program, you're going to TheMuscleReport. Here is where you can find a program that we finally gave the results I wanted it badly.


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Heather Locklear 'secretly entered rehab'
Heather Locklear reportedly entered a rehab centre after her split from actor Jack Wagner.
A source claims that the actress has been battling an alcohol problem for many years and quietly sought help following the couple's break-up last year.
The 50-year-old Melrose Place actress was recently hospitalised after reportedly mixing alcohol with prescription medication.
According to the insider, her 52-year-old partner had "begged her to go to rehab," but Heather didn't take action until after their split when she "entered a treatment program, which her family was able to keep quiet," American publication US Weekly reports.
The source claims the star's drinking has been an issue for some time and got even worse since her engagement fell apart.
Heather has suffered personal problems in the past. In 2008 it was claimed she'd tried to commit suicide, although the allegation was later denied. She was helped for anxiety and depression issues later that year.
"Heather has been out of control for many years," the source claimed. "Her drinking has caused her to fall out of many friendships. She doesn't get out of bed most days. Jack kept her on the straight and narrow, but he couldn't keep Heather sober."
Following her recent hospitalisation the star is said to be "weighing her options" on whether to check into rehab.
Her family is concerned and reportedly want Heather to get professional help.
© Cover Media


text:
You are probably already aware of many household dangers for cats, such as certain toxic human foods, poisonous plants, and so on. But there are various other items, common in many homes, that could potentially harm your curious pet. Because cats are so curious, it's best to keep these things out of reach. Following are five little-known household dangers for cats.
1. String on blinds. The strings that are used to pull window blinds open and closed may seem harmless, but I once heard the story of a kitten who got her paw wrapped up in one of these strings and hung there by the paw because she wasn't able to get loose. After hearing this, I have been careful to keep the strings tucked up out of my cat's reach. However, one night my husband woke up to the most pitiful meow, only to find our adult cat, Loki, caught in the string by her back leg, struggling to get free. We are glad the only blinds in our house are in the bedroom, but we are much more careful with them now.
2. Yarn. I have also heard the story of another curious kitten who died from intestinal damage done by yarn. We often associate balls of yarn with cats, but they can actually be fatal to your pet. When a cat starts to chew on a string of yarn, it will stick to his rough tongue and he might not be able to get it back out. As it passes through the digestive system, the yarn will often become tangled in the intestines, eventually causing death.
3. Dental floss. As with the yarn, dental floss is another common household item that can become entangled in the intestines. If your cat enjoys playing with string, be sure to keep your dental floss out of sight so she doesn't get tempted by it.
4. Rubber bands. Again, rubber bands can cause internal damage to your pet, and should be kept out of reach. Loki enjoys chewing on my ponytail holders, and I have found them chewed apart on several occasions. I even found a digested one in the litter box once. Since then, I am very careful to keep them away from her.
5. Plastic bags. Grocery bags could suffocate, or even strangle, your cat; if yours is anything like Loki, he or she probably loves to hide inside bags of any kind. Plastic bags can be dangerous, so tuck them away as soon as they are unloaded, and tie each into a knot for good measure. Poor kitty has gotten her head stuck in the handles in the past, and this naturally causes panic, making the situation worse. Also, if you allow your cat to play inside paper bags with handles, make sure to cut them off before letting him have it.
More from Tonya:
Tips to control shedding in cats
Ways to go green with your cat
Help your indoor cat exercise


text:
Siren Song
Paperback, 382 Pages
Price: $8.01
Prints in 3-5 business days
After falling in with an old school friend he's not seen for thirty years, Nick Robinson's down at heel life enjoys a fantastic transformation. A job to die for leads to love and a new life. A bright future seems assured. But then a shocking betrayal has catastrophic consequences. Overnight, Robinson's life becomes a hallucinagenic runaway roller coaster ride that plunges him headlong towards insanity. He escapes to the Undine Resort on the island of Tuscarora, a tropical paradise that hides a dark and terrible secret purpose, to recuperate and put his shattered life in some semblance of order. There he meets and falls for the hypnotically beautiful Kharmina, and finds that nothing is what it seems...
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Product Details
- Copyright
- Simon D. Smith (Standard Copyright License)
- Edition
- Second Edition
- Publisher
- Simon D. Smith
- Published
- October 9, 2016
- Language
- English
- Pages
- 382
- Binding
- Perfect-bound Paperback
- Interior Ink
- Black & white
- Weight
- 2.45 lbs.
- Dimensions (inches)
- 5.5 wide x 8.5 tall
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Learn The Major Reason Of The Blood That We Have In Our Bodies
Your blood enters each cell and organ and simply clean-up all the natural and unnatural wastes. It takes them to your colon or to your bladder, then they are nicely, as the body was formed, got rid of. Your body is faintly alkaline, this is precisely what you want to be healthy.A Lot Of Excellent Outdoor Furniture Umbrellas: Just Have A Look!When you seek an outdoor furniture umbrella you might wish to look into an offset umbrella rather than the more conventional variety. Those newer models allow for more space under the shelter of the umbrella making them perfect for entertaining. Many people will use them near a swimming pool or around a fire pit in the evening. Naturally if you are going to use it near a fire you require to make sure it is flame proof. This design is very adaptable as it can be moved from one position to another by only changing the angle of the supporting pole. You no longer need to move heavy stands from one side of the garden to another.
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The Ultimate Blog For Planning A Luxury Wedding On A Shoestring Budget
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Ask Health Experts and Get Answers to Your Health Question ASAP
Thank you for your question.
I am Dr Saha, I shall try my best to help you.
Since when are you having this issue?
Any trauma?
Did you try any measure?
Can you send picture?
Thank you for all the information,
This can be an infected cyst.Cyst can occur if the duct of a gland gets obstructed & secretions get collected inside.Fungal or bacterial infection is possible.I would suggest to take an examination by a gynecologist.The doctor can prescribe antibiotics, drain the cyst or do marsupialization.This will relieve your symptoms.Meanwhile,you can apply warm moist compress or can take sitz bath.This is sitting in warm water tub.
You can use the link on it.
http://www.healthline.com/health/sitz-bath#Uses2You can take anti inflammatory analgesics like motrin or naproxen, if there is no other contraindication.
Those will relieve the pain.
I hope this information helps.If there's anything else I can do, please let me know.If you are satisfied, please rate my answer as good or excellent.Regards.
You are always welcome.
Yes, the smell suggests an infection.
Antibiotic will be required.
Till you see doctor. please take the measures, I suggested.
Those will relieve your discomfort.If you are satisfied, please click on 5 star rating.Best wishes.


text: Adapting Mona Simpson's novel about a single mom who flees Wisconsin for Beverly Hills with her sulky daughter, director Wayne Wang doesn't work his Joy Luck Club magic with Anywhere But Here. Natalie Portman eloquently expresses teen angst — often without saying a word — but Susan Sarandon isn't always convincing as the overbearing, immature bane of her existence. If you have time for just one of last year's mother-daughter dramas, try Tumbleweeds. C+


text:
Tuesday, March 31, 2015
Nuances of Self
I've mentioned the blogs name before. Low Sec Lifestyle. I picked it because I was living in low sec and I really, really liked just living in low sec. This was before I could hunt or kill anything. I was a pest buzzing along behind experienced players like an excited puppy. I knew nothing but fear and awe for the most part. I picked the blog name to reflect what I was doing. Living in low sec.
I've said before that I didn't come to Eve to be a PvPer. I came to be an industrialist. I just came to be one in an environment that was hostile and dangerous. I wanted an environment where I was at risk. I wanted to be chased by pirates and gun them down and sometimes win and sometimes lost. That was interesting to me. It still is. It also makes my evolution from Chella Ranier the industrialist to Sugar Kyle the pirate and into Sugar Kyle the member of the CSM all the more strange.
Sugar is my main because Sugar kills people and killing people is one of the few measurable things one can do in Eve. When Sugar started to kill people she started to leave her name behind her on public killboards. It is a trackable metric and one that I have watched over the course of my game play not to personally measure but to see how people react to it.
In Eve Uni chat, new players will see my sec status (-6.0 atm). The ones that understand killboards will see my activity. In fact, when you look into someone in Eve running their name through one of hte major killboards is a very basic step. Who is this person? What is this person? Do they kill or are they killed? What decisions do they make that you can see in this killboard. The fits. The fights. The fleets. They all tell a story about a person that you can read and gather some solid and true knowledge of them.
Inactivity brings its own responses. For every inactive period on my killboard I have a reason. You can see slumps for each Pod and Planet fiction writing contest I have entered. You can see vacations and these days, you can see the increased energy I have put into the CSM and the decreased activity of the killboard. That has led to people asking why I should continue on the CSM if I am inactive in the game.
In some ways activity can define a main. I am Sugar Kyle. But I am also a handful of other players. I am The Cougar Store and TCS is composed of four characters. They are not individuals. Their skills are pretty much mirrored on each other and their existence is to create and maintain a concept. That concept is a low sec market. In that, I am defined as a marketeer of some sort and type as a player. Sugar gains that title but Sugar cannot market. She has no skills for it.
Sugar is an almost seventy million skill point combat pilot. If I were to pick what ship I fly most it is probably one of my freighters. My freighter pilot has more in space time on her than almost anyone else. Yet, she is not my main. I'd never even consider her such. She is another aspect of Sugar. She moves items, she handles logistics, she builds things, and she markets my non TCS items. She is one of my most important and valuable characters when it comes to skills and moving forward my personal game of Eve but I'd never think of her as my main.
I do write about her adventures. I've learned a paranoid fear of red thrashers on gates and neutral Machariel's when I am in a freighter or Orca. I write about my market and industrial activities but they do not quantify the same way that PvP does. I have spun up billion ISK projects and learned the true pain of being a small scale manufacturer. I have struggled with spreadsheets and build freighters in low sec to handle the demands of my projects. I do these things in, for, and about low sec because that is the space that I love. It is my low sec lifestyle but it is not quantifiable. And thus, with a quiet kill-board I am inactive. For how can they prove what I do?
I think what makes a main is more than our personal view of it. It is the external view as well. I do not know Eve Hermit's main but I know his Eve Hermit character is not it. Yet I know Croda trades across multiple accounts and I'd call Croda his main because his tangible connection to me is through his blog where he recounts what he does for we have no other way of sharing it.
The complexity of a main comes into clear view when people start discussing the CSM in a breakdown of region. You buy the player when you select a candidate. I am a pirate, marketeer, industrialist, explorer. I am all of these things across many areas of space. But low ssec is what I put first yet it is not all that I am.
Am I the player or the character?
Like the rest of Eve there are layers within layers. We are the player, the character, and often the alts. It's one, textured expierence. But to put a name to it, that'd be Sugar Kyle, low sec resident.
5 comments:
- DireNecessityMarch 31, 2015 at 3:56 PM
Identity is such richly complicated stuff. Being a lazy butt, I'll cut and paste my comment from his post:ReplyDelete
DireNecessityMarch 20, 2015 at 9:27 AM
What's the difference between Love and Infatuation? If it lasts.
Much the same can be said of the contrast between 'dabble' and 'top playstyle'. Accordingly . . . a little history.
My first character spawned in May 2009: Similar to so many others, a Hi-Sec mission runner.
My second character spawned in September of that same year: Faction warfare PvP.
My third character spawned in January 2010: Value added manufacturing.
One could say these are my three mains. I'd be hard pressed to assert one is more central than the other as one of the great joys I find in Eve is [getting] each of them contributing their part to the overall endeavor. I don't have a main, I have a family.
Character two dabbles: touch of faction warfare, stint as Mission Bear murdering ninja looter, spell as a suicide ganker, mercenary stretch. She's currently unemployed but the ship on ship PvP itch returns – something's about to change.
Character three began and remains an industrialist: By my count her industrial business has undergone four top to bottom reorganizations since early 2010 (Crius alone generated two of them). History would say this is my primary playstyle. Over five years of unrelenting, no pause production.
Character one, the oldest of the set with by far the most skill points, appears to fade into the background but don't you believe it. He supports both character two (scouting, spinning command link) and character three (freighter transportation, optimal npc standing reprocessing). If a character is me, he's the one; the central hub the other characters circle around.
Family Spokesperson,
Lets say my "main" is my demeanor, my projection of who I want to be, an adventurer, a nosy anthropologist.ReplyDelete
My alts? My nature. Geeky, multitasking introverts dedicated to the next project, production or generation of resources towards that goal, forever sidetracked by the next investigation.
I think my alts are "me", my RL me. Supporting my main, my non-RL me.
Who's more me? The me? Or the me that follows him?
I totally have to credit Dire with that question. It was a very good one; dare I say a blog banter? Great response, Sugar!ReplyDeleteReplies
- DireNecessityApril 1, 2015 at 9:17 AM
As the preamble of your post points out, it's not only a puzzling individual identity question, it's a question whose answers can have consequences on CCP's development priorities (presuming we prefer CCP spiff up our 'primary play' first). Sugar's inclusion of external aspects of the question (who do others - including CCP - see as your main) muddies these difficult waters even further.Delete
My main is probably closest to myself: A space archaelogist travelling around like a nomad. Three things I can't do in real life, regardless of how hard I wish myself into a spaceship.ReplyDelete
My alts are on a sliding scale of important to unimportant: Starting with interesting concepts with actual bios and then sliding down to private in-jokes.


text:
Contact Info / Websites
Entry #13
http://www.ngup.net/view.php?file=tank me n%20spritesheet%202
here is a link to a tankmen sheet I made.
If you use it please give credit.
- 3 comments
You must be logged in to comment on this post.
2007-10-18 10:05:27
Link is fucked up.
Pm me for proper link.
2007-10-18 12:16:10
Yeah the link doesnt work :(
luke734 responds:
I dont see why it messed up, if you want the link pm me.


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Setting Bases for TAPER-LOC® XA Models
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text:
In this episode, Amelia will be talking about wardrobes, linens, laundries and mudrooms.
She'll also cover walk-in robes and other storage. These spaces can be important to get right for a home to work well, so let's learn more.
In this episode, Amelia talks about the four Fs upfront and gets through them quite quickly.
Then, she tackles each of these spaces individually, and shares some key mistakes and design tips for each. And in each she talks about where to locate it in your home, and how to connect it to other spaces and rooms so it works as conveniently as possible.
Because convenience is what these spaces are ALL about. When you get it right in these rooms and spaces … when you nail how they work functionally … then it not only assists you in your home. It makes life simpler for everyone, and is a serious sanity saver in family homes.
This is the list of rooms and spaces Amelia talks about in this episode.
Firstly, wardrobes. So these are built-in robes that are a fixed object in a room – and usually a bedroom.
Then there's walk-in robes. These are little (or big) rooms for storing clothing. They'll sometimes be more like a dressing room, with an ottoman or something similar in the middle.
Next, there's linen cupboards. So these are for storing sheets, towels, blankets, and other types of items required for our beds and our homes. They can also be general storage for other things.
There's also broom cupboards. These are generally similar to linen cupboards, with less shelving in them, so you can have space for vertical items such as brooms and mops.
Then, Amelia talks about two rooms … mud rooms and laundries. These rooms can be two separate ones in different parts of your home from each other. They can also be right next door to each other, or combined into the same space. Another name for a mudroom is a boot room.
Listen to the podcast now, and learn how to get it right in your wardrobes, linen, laundry and mudroom.
And if you want to learn more about how to design your home, Amelia has created a special (and free!) e-guide for you. It's called "How to Design a Home: 5 Simple Steps to Getting it Right".
Head to www.undercoverarchitect.com/homedesign to get your copy emailed straight to your inbox. It will give you a fantastic head start on designing your home – whether you're working with a design professional or not.


text:
Your Favorite New Tumblr Will Probably Be 'Who Is Frank Ocean?'
If you're at all into pop culture, music or reading things on the Internet, then you probably heard about Frank Ocean before the 2013 Grammys. Sadly, you're probably also in the minority right now. Because apparently a lot of the people watching the Grammy Awards last night did not know who Frank Ocean was — and therefore did not understand why he kept leaving his seat to make speeches on stage. Every time the camera panned to Frank Ocean, they'd point at the TV, turn to their friends and shout, "that guy! Who is that guy!" And their friend would say, "I dunno, Tommy Rivers or something."
While some people might be reading this and shaking their heads, I'm giddy with glee over the news. Because as an internet aficionado, I know that a tumblr always follows in the wake of widespread internet ignorance. Before the show even ended last night, someone launched "Who is Frank Ocean" — a collection of tweets asking that very question.
Did these people mean to type that question into Google instead of Twitter? No, no they didn't. Bing? Not a chance. Ask Jeeves? Go back to 1999 you time traveler!
Despite taking time out of their lives to watch a music awards show, they preferred to tweet out their ignorance and make a strong point about how little they know about it. It, being music. It's cute.
Almost as cute people defending Chris Brown's choice to remain seated when Frank Ocean won the award for best urban contemporary album. Oh the Internet! It's so full of people I would never want to eat brunch with in real life. You know, the kind of people who watched this performance and thought, "security! get this weirdo off stage! he doesn't even go here!"
(Photo: Adriana M. Barraza/WENN.com)


text:
costume shop cyberstalker
Costumed Cyberstalker Interview Fail
A crazy costume shop owner has been accused of cyberstalking a business competitor, but doesn't take the charge too seriously, as proven when a reporter visits her at work. Watch Video ›
Costume Shop Cyberstalker Report
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text:
Zurich Center for Integrative Human Physiology
Zurich Center for Integrative Human Physiology
Lienemann P.S.,University of Zürich |
Lienemann P.S.,Ecole Polytechnique Federale de Lausanne |
Lutolf M.P.,Ecole Polytechnique Federale de Lausanne |
Ehrbar M.,University of Zürich |
Ehrbar M.,Zurich Center for Integrative Human Physiology
Advanced Drug Delivery Reviews | Year: 2012
The regeneration of large bone defects caused by trauma or disease remains a significant clinical problem. Although osteoinductive growth factors such as bone morphogenetic proteins have entered clinics, transplantation of autologous bone remains the gold standard to treat bone defects. The effective treatment of bone defects by protein therapeutics in humans requires quantities that exceed the physiological doses by several orders of magnitude. This not only results in very high treatment costs but also bears considerable risks for adverse side effects. These issues have motivated the development of biomaterials technologies allowing to better control biomolecule delivery from the solid phase. Here we review recent approaches to immobilize biomolecules by affinity binding or by covalent grafting to biomaterial matrices. We focus on biomaterials concepts that are inspired by extracellular matrix (ECM) biology and in particular the dynamic interaction of growth factors with the ECM. We highlight the value of synthetic, ECM-mimicking matrices for future technologies to study bone biology and develop the next generation of 'smart' implants. © 2012 Elsevier B.V.
Marini F.,University of Milan Bicocca |
Tagliabue C.F.,University of Milan Bicocca |
Sposito A.V.,University of Milan Bicocca |
Hernandez-Arieta A.,Noser Engineering AG |
And 4 more authors.
Neuropsychologia | Year: 2014
The way in which humans represent their own bodies is critical in guiding their interactions with the environment. To achieve successful body-space interactions, the body representation is strictly connected with that of the space immediately surrounding it through efficient visuo-tactile crossmodal integration. Such a body-space integrated representation is not fixed, but can be dynamically modulated by the use of external tools. Our study aims to explore the effect of using a complex tool, namely a functional prosthesis, on crossmodal visuo-tactile spatial interactions in healthy participants. By using the crossmodal visuo-tactile congruency paradigm, we found that prolonged training with a mechanical hand capable of distal hand movements and providing sensory feedback induces a pattern of interference, which is not observed after a brief training, between visual stimuli close to the prosthesis and touches on the body. These results suggest that after extensive, but not short, training the functional prosthesis acquires a visuo-tactile crossmodal representation akin to real limbs. This finding adds to previous evidence for the embodiment of functional prostheses in amputees, and shows that their use may also improve the crossmodal combination of somatosensory feedback delivered by the prosthesis with visual stimuli in the space around it, thus effectively augmenting the patients' visuomotor abilities. © 2013 Elsevier Ltd.
Blau N.,University of Zürich |
Blau N.,Zurich Center for Integrative Human Physiology |
Van Spronsen F.J.,University of Groningen |
Levy H.L.,Harvard University
The Lancet | Year: 2010
Phenylketonuria is the most prevalent disorder caused by an inborn error in aminoacid metabolism. It results from mutations in the phenylalanine hydroxylase gene. Phenotypes can vary from a very mild increase in blood phenylalanine concentrations to a severe classic phenotype with pronounced hyperphenylalaninaemia, which, if untreated, results in profound and irreversible mental disability. Neonatal screening programmes identify individuals with phenylketonuria. The initiation of a phenylalanine-restricted diet very soon after birth prevents most of the neuropsychological complications. However, the diet is difficult to maintain and compliance is often poor, especially in adolescents, young adults, and pregnant women. Tetrahydrobiopterin stimulates phenylalanine hydroxylase activity in about 20 of patients, and in those patients serves as a useful adjunct to the phenylalanine-restricted diet because it increases phenylalanine tolerance and allows some dietary freedom. Possible future treatments include enzyme substitution with phenylalanine ammonia lyase, which degrades phenylalanine, and gene therapy to restore phenylalanine hydroxylase activity. © 2010 Elsevier Ltd.
Heintz C.,University of Zürich |
Cotton R.G.H.,Human Variome Project |
Blau N.,University of Zürich |
Blau N.,Zurich Center for Integrative Human Physiology |
Blau N.,University of Heidelberg
Human Mutation | Year: 2013
In about 20%-30% of phenylketonuria (PKU) patients (all phenotypes of PAH deficiency), Phe levels may be controlled through phenylalanine hydroxylase cofactor tetrahydrobiopterin therapy. These patients can be diagnosed by an oral tetrahydrobiopterin challenge and are characterized by mutations coding for proteins with substantial residual PAH activity. They can be treated with a commercially available synthetic form of tetrahydrobiopterin, either as a monotherapy or as adjunct to the diet. This review article summarizes molecular and metabolic bases of PKU and the importance of the tetrahydrobiopterin loading test used for PKU patients. On the basis of in vitro residual PAH activity, more than 1,200 genotypes from patients challenged with tetrahydrobiopterin were categorized as predictive for tetrahydrobiopterin responsiveness or non-responsiveness and correlated with the loading test, phenotype, and residual in vitro PAH activity. The coexpression of two distinct PAH mutant alleles revealed possible dominance effects (positive or negative) by one of the mutations on residual activity as result of interallelic complementation. The treatment of the transfected cells with tetrahydrobiopterin showed an increase in residual PAH activity with several mutations coexpressed. Tetrahydrobiopterin (BH4; Kuvan®) induces a gain-of-function in phenylalanine hydroxylase (PAH) in a multifactorialresponse mechanism with a notable stabilization of protein structure. In about 20%-30% of phenylketonuria patients (all phenotypes of PAH deficiency), Phelevels may be controlled through PAHcofactor BH4 therapy. A substantial residual PAH activity is essential for the stabilization of enzyme activity and depends on specific PAH gene variations and on interallelic complementation, as shown from in vitro co-expression experiments.© 2013 WILEY PERIODICALS, INC.
Blau N.,University of Heidelberg |
Blau N.,University of Zürich |
Blau N.,Zurich Center for Integrative Human Physiology
Expert Opinion on Drug Metabolism and Toxicology | Year: 2013
Introduction: Phenylketonuria (PKU) is caused by mutation of the enzyme, phenylalanine (Phe) hydroxylase (PAH). The hyperphenylalaninemia characteristic of PKU causes devastating neurological damage if not identified and treated at birth with a Phe-restricted diet. Sapropterin dihydrochloride, a pharmaceutical formulation of the natural cofactor for PAH (6R-tetrahydrobiopterin; BH4), is now available for the management of hyperphenylalaninemia in some PKU patients, including BH4 deficiencies. Sapropterin dihydrochloride improves dietary Phe tolerance in about 20% of patients with PKU. Areas covered: This evaluation describes the identification of patients suitable for treatment of sapropterin dihydrochloride, together with its indications, therapeutic properties and efficacy. Furthermore, the article reviews its safety and tolerability in patients with PKU or BH4 deficiency. Expert opinion: A reduction in blood Phe of at least 30% occurred in ∼ 20-30% of sapropterin-treated PKU patients (mostly with milder forms of PKU). Treatment with sapropterin resulted in clinically significant and sustained reductions in blood Phe concentrations and increased dietary Phe tolerance in well-designed clinical studies in PKU patients who responded to BH4. Successful treatment with sapropterin may lead to a relaxation of the Phe-restricted diet, although continued monitoring of blood Phe is required. Sapropterin was well tolerated. © 2013 Informa UK, Ltd.
Berger W.,University of Zürich |
Berger W.,Neuroscience Center Zurich |
Berger W.,Zurich Center for Integrative Human Physiology |
Kloeckener-Gruissem B.,University of Zürich |
And 2 more authors.
Progress in Retinal and Eye Research | Year: 2010
During the last two to three decades, a large body of work has revealed the molecular basis of many human disorders, including retinal and vitreoretinal degenerations and dysfunctions. Although belonging to the group of orphan diseases, they affect probably more than two million people worldwide. Most excitingly, treatment of a particular form of congenital retinal degeneration is now possible. A major advantage for treatment is the unique structure and accessibility of the eye and its different components, including the vitreous and retina. Knowledge of the many different eye diseases affecting retinal structure and function (night and colour blindness, retinitis pigmentosa, cone and cone rod dystrophies, photoreceptor dysfunctions, as well as vitreoretinal traits) is critical for future therapeutic development. We have attempted to present a comprehensive picture of these disorders, including biological, clinical, genetic and molecular information. The structural organization of the review leads the reader through non-syndromic and syndromic forms of (i) rod dominated diseases, (ii) cone dominated diseases, (iii) generalized retinal degenerations and (iv) vitreoretinal disorders, caused by mutations in more than 165 genes. Clinical variability and genetic heterogeneity have an important impact on genetic testing and counselling of affected families. As phenotypes do not always correlate with the respective genotypes, it is of utmost importance that clinicians, geneticists, counsellors, diagnostic laboratories and basic researchers understand the relationships between phenotypic manifestations and specific genes, as well as mutations and pathophysiologic mechanisms. We discuss future perspectives. © 2010 Elsevier Ltd.
Moes A.D.,Erasmus Medical Center |
Van Der Lubbe N.,Erasmus Medical Center |
Zietse R.,Erasmus Medical Center |
Loffing J.,University of Zürich |
And 2 more authors.
Pflugers Archiv European Journal of Physiology | Year: 2014
SLC12A3 encodes the thiazide-sensitive sodium chloride cotransporter (NCC), which is primarily expressed in the kidney, but also in intestine and bone. In the kidney, NCC is located in the apical plasma membrane of epithelial cells in the distal convoluted tubule. Although NCC reabsorbs only 5 to 10 % of filtered sodium, it is important for the fine-tuning of renal sodium excretion in response to various hormonal and non-hormonal stimuli. Several new roles for NCC in the regulation of sodium, potassium, and blood pressure have been unraveled recently. For example, the recent discoveries that NCC is activated by angiotensin II but inhibited by dietary potassium shed light on how the kidney handles sodium during hypovolemia (high angiotensin II) and hyperkalemia. The additive effect of angiotensin II and aldosterone maximizes sodium reabsorption during hypovolemia, whereas the inhibitory effect of potassium on NCC increases delivery of sodium to the potassium-secreting portion of the nephron. In addition, great steps have been made in unraveling the molecular machinery that controls NCC. This complex network consists of kinases and ubiquitinases, including WNKs, SGK1, SPAK, Nedd4-2, Cullin-3, and Kelch-like 3. The pathophysiological significance of this network is illustrated by the fact that modification of each individual protein in the network changes NCC activity and results in salt-dependent hypotension or hypertension. This review aims to summarize these new insights in an integrated manner while identifying unanswered questions. © 2013 Springer-Verlag Berlin Heidelberg.
Werner E.R.,Innsbruck Medical University |
Blau N.,University of Zürich |
Blau N.,Zurich Center for Integrative Human Physiology |
Blau N.,Research Center for Children |
And 3 more authors.
Biochemical Journal | Year: 2011
BH 4 (6R-L-erythro-5,6,7,8-tetrahydrobiopterin) is an essential cofactor of a set of enzymes that are of central metabolic importance, including four aromatic amino acid hydroxylases, alkylglycerol mono-oxygenase and three NOS (NO synthase) isoenzymes. Consequently, BH 4 is present in probably every cell or tissue of higher organisms and plays a key role in a number of biological processes and pathological states associated with monoamine neurotransmitter formation, cardiovascular and endothelial dysfunction, the immune response and pain sensitivity. BH 4 is formed de novo from GTP via a sequence of three enzymatic steps carried out by GTP cyclohydrolase I, 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase. An alternative or salvage pathway involves dihydrofolate reductase and may play an essential role in peripheral tissues. Cofactor regeneration requires pterin-4a-carbinolamine dehydratase and dihydropteridine reductase, except for NOSs, in which the BH 4 cofactor undergoes a one-electron redox cycle without the need for additional regeneration enzymes. With regard to the regulation of cofactor biosynthesis, the major controlling point is GTP cyclohydrolase I. BH 4 biosynthesis is controlled in mammals by hormones and cytokines. BH 4 deficiency due to autosomal recessive mutations in all enzymes, except for sepiapterin reductase, has been described as a cause of hyperphenylalaninaemia. A major contributor to vascular dysfunction associated with hypertension, ischaemic reperfusion injury, diabetes and others, appears to be an effect of oxidized BH 4, which leads to an increased formation of oxygen-derived radicals instead of NO by decoupled NOS. Furthermore, several neurological diseases have been suggested to be a consequence of restricted cofactor availability, and oral cofactor replacement therapy to stabilizemutant phenylalanine hydroxylase in the BH 4-responsive type of hyperphenylalaninaemia has an advantageous effect on pathological phenylalanine levels in patients. ©The Authors Journal compilation © 2011 Biochemical Society.
Jacobs R.A.,Zurich Center for Integrative Human Physiology |
Jacobs R.A.,University of Zürich |
Lundby C.,Zurich Center for Integrative Human Physiology |
Lundby C.,University of Zürich
Journal of Applied Physiology | Year: 2013
Changes in skeletal muscle respiratory capacity parallel that of aerobic fitness. It is unknown whether mitochondrial content, alone, can fully account for these differences in skeletal muscle respiratory capacity. The aim of the present study was to examine quantitative and qualitative mitochondrial characteristics across four different groups (n = 6 each), separated by cardiorespiratory fitness. Highresolution respirometry was performed on muscle samples to compare respiratory capacity and efficiency in active, well-trained, highly trained, and elite individuals. Maximal exercise capacity (ml O2·min-1·kg-1) differed across all groups, with mean ± SD values of 51 ± 4, 64 ± 5, 71 ± 2, and 77 ± 3, respectively. Mitochondrial content assessed by citrate synthase activity was higher in elite trained compared with active and well-trained (29 ± 7 vs. 16 ± 4 and 19 ± 4 nmol·min -1·mg wet wt-1, respectively). When normalizing respiration to mitochondrial content, the respiratory capacities during maximal fatty acid oxidation (P = 0.003), maximal state 3 respiration (P = 0.021), and total electron transport system capacity (P = 0.008) improved with respect to maximal exercise capacity. The coupling efficiency of β-oxidation, however, expressed no difference across groups. These data demonstrate the quantitative and qualitative differences that exist in skeletal muscle mitochondrial respiratory capacity and efficiency across individuals that differ in aerobic capacity. Mitochondrial-specific respiration capacities during β-oxidation, maximal oxidative phosphorylation, and electron transport system capacity all correspondingly improve with aerobic capacity, independent of mitochondrial content in human skeletal muscle. Copyright © 2013 the American Physiological Society.
Brugger P.,University of Zürich |
Brugger P.,Zurich Center for Integrative Human Physiology |
Lenggenhager B.,University of Zürich |
Lenggenhager B.,Zurich Center for Integrative Human Physiology
Current Opinion in Neurology | Year: 2014
Purpose of review The experience of ourselves as an embodied agent with a first-person perspective is referred to as 'bodily self'. We present a selective overview of relevant clinical and experimental studies. Recent findings Sharing multisensory body space with others can be observed in patients with structurally altered bodies (amputations, congenital absence of limbs), with altered functionality after hemiplegia, such as denial of limb ownership (somatoparaphrenia) and with alterations in bodily self-consciousness on the level of the entire body (e.g. in autoscopic phenomena). In healthy participants, the mechanisms underpinning body ownership and observer perspective are empirically investigated by multisensory stimulation paradigms to alter the bodily self. The resulting illusions have promoted the understanding of complex disturbances of the bodily self, such as out-of-body experiences. We discuss the role of interoception in differentiating between self and others and review current advances in the study of body integrity identity disorder, a condition shaped as much by neurological as by social-psychological factors. Summary We advocate a social neuroscience approach to the bodily self that takes into account the interactions between body, mind and society and might help close the divide between neurology and psychiatry. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.


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Property Details
4B Castlebrook Lane, Centrepointe, Ottawa, ON, K2G 5E2, Canada
Great Location for the Perfect Starter Home. 3Bed/2Bath Features a Cozy Wood Burning Fireplace and Wood Floor in the Living Room with the Formal Dining Room Overlooking the Family Room also Featuring Wood Floor. Ceramic Tile Floor throughout the Bright Foyer and into the Main Traffic Area, Powder Room and Kitchen. Neutral Kitchen Decor offers Generous Counter Top and Cupboard Space with all Appliances Included. Family Room is Located just down the Oak Hardwood Stairs. Large Storage Space in the Basement. The Upper Level Features a Skylight Overlooking the Main Hallway and 3 Good Sized Bedrooms. The Yard with No Rear Neighbours and Mature Trees. Parking and Guest Parking Nearby. Recent Updates Include PVC Windows, Patio Door, Front Door, Roof and Carpets Through all Bedrooms. Walk to Algonquin College, Ben Franklin Place, Shopping and Public Transit.
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You can add your favorite baby boy and girl names to your own "personal list " with different edit features that will allow you to customize your list. Start choosing.
Names for girls, baby girl names, baby girls names. Congratulations on your new baby girl! What to call her? 2017 update. Here is a list of hundreds of names for....
Baby girl names listing - - travelingThe world is not yet ready for another generation of male Seymours and Sheldons, although keep in mind that among the hottest boys' names in the UK now are Harvey and Leon. A sampling of baby names frequently heard in The Netherlands for girls: Feminizations are, in the classic sense, feminine variations of male names rather than unisex baby names. These names relate to a range of impressive personages, real and imagined, and also have both breadth and depth in terms of the meaning they convey. While many Biblical names certainly qualify, we've grouped most of those on their own list. Choose baby boy and girl names from a variety of categories including American, Arabic, French, German, Hawaiian, Hebrew, Italian, Spanish, plus... Easy Recipes Dinner Ideas Chicken Recipes Crock Pot Recipes Breakfast Recipes Breakfast Casseroles Make a mouthwatering breakfast recipe or an easy, delicious breakfast casserole to turn any day into a special day. Ava is one of the hottest names of the past decade, rising from obscure Hollywood Glamour Girl appellation to sleek modern star.
Mama Shirley Main Dishes. Bible names for girls have been popular for girls for more than a generation now, with early favorites Mary and Anna giving way to new favorites performing arts theatre ticketing as Ada and Abigail. Popular Girl Boy Unisex Celebrity Search Namehunter. Names lists based on statistics, that may predict the future for your baby. Some Eva alternatives you may want to consider: Samantha may have long been your favorite among baby girl names, but there are fresher substitutes you may want to consider today. Okay, all these girls' baby names don't literally end with S. Start saving time and money in your kitchen with these easy family-friendly recipes, packed with flavor. Quotes to Live By. Make a mouthwatering breakfast recipe or an easy, delicious breakfast casserole to turn any day into a special day. Find a beautiful name for your new daughter with easy to use lists of names and name meanings for girls. Warm Spiced Bread Pudding Recipe. The princess names for girls here are those chosen by royal families around the world over the past decade or so, baby girl names listing. You have to be pretty darn cool botticelli inspired fashion film name your kid Hortense, cool in that I-like-it-and-I-don't-care-what-the-world-thinks kind of way. Christina, the feminine of Christopher, has many intriguing international variations. Here are some baby names that fit that. Here's a list of romantic girl names chosen for their originality, use in literature and film, as well as romance novels: Royal names on this list come from those used by the British royal family over the centuries. We're in a nickname-friendly era, and these adorable double baby names like Coco and Lulu are in keeping with that trend.
Travel Seoul: Baby girl names listing
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Baby girl names listing -- traveling Seoul
By Ethnicity African Arabic Aramaic Armenian Basque Catalan Celtic Chinese Czech Danish Dutch Egyptian English Finnish French Gaelic German Germanic Greek Hawaiian Hebrew Hindi Hungarian Indian Irish Italian Japanese Korean Latin Literary Maori Mayan Native American Norwegian Old English Old Norse Persian Phoenician Polish Portuguese Russian Sanskrit Scottish Slavic Spanish Swedish Thai Turkish Vietnamese Welsh Yiddish See All... Baby names for your own little goddess might include the following. List all girls names with initial:. So what if you want to transcend the basics like, nowadays, Rose and Grace, but still want a one-syllable middle name for your daughter? See All List Categories.. Sometimes, all you have to do is add an a to the end to bump them up several coolness levels: Natalie to Natalia, Susan to Susanna -- you get the picture.


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increased levels of oxidized LDL (oxLDL) accumulate in atherosclerotic lesions, promote atherosclerotic process, and may cause endothelial dysfunction including disruption of endothelial barrier, impairment of nitric oxide signaling, and decreased endothelial cell migration. In addition, oxLDL alters cellular biomechanical properties, which appear to be important for endothelial mechanotransduction, wound repair, or angiogenesis.
The study by Shentu et al. (6), the current article in focus (published in this issue of American Journal of Physiology-Cell Physiology), investigates the effects of oxLDL on the lipid order of membrane domains in endothelial cells and explores relations between changes in thermodynamic membrane parameters and cell stiffness, contractility, and angiogenic potential. A previous study by this group tested the effects of oxLDL elevation on endothelial mechanical properties by micropipette aspiration technique (4). The results showed that aortic endothelial cells isolated from hypercholesterolemic pigs were significantly stiffer compared with normocholesterolemic controls and that oxLDL caused disappearance of lipid raft marker GM1 from the plasma membrane, although global changes in membrane cholesterol were minuscule. For elucidation of oxLDL effects on lipid packaging of endothelial membranes in the study published in this issue, the authors used two-photon imaging of the fluorescent probe Laurdan, which is sensitive to the local environment and undergoes a red shift at the boundary of gel and fluid phases. The number of such boundaries is reflected by Laurdan red shift in fluorescence, which changes fluorescence ratio from 410–490 nm (gel phase) to 503–553 nm (fluid phase). This approach allowed the authors a topographical mapping of ordered and disordered plasma membrane lipid domains and their quantitative analysis. Preferential peripheral localization of ordered lipid domains was affected by cholesterol extracting compound methyl-β-cyclodextrin (MβCD) and more importantly, by oxLDL, and was reversed by cell membrane replenishing with cholesterol. Similarly to oxLDL, 7-keto-cholesterol, the major oxysterol found in oxLDL as well as androstenol, also decreased membrane lipid packing in ordered domains. Interestingly, oxLDL-induced cholesterol depletion in the cell membrane lipid ordered domains appears to be via increased cholesterol efflux from endothelial cell membranes, but not due to increased cholesterol internalization. The mechanisms of cholesterol efflux triggered by oxLDL remain to be explored.
Previous reports (2) and the current study suggest that oxLDL can actually act as cholesterol acceptor and remove cholesterol from endothelial caveolae, the structures that function as crossroads of many signaling pathways in endothelial cells. Similarly, oxidation products of palmitoyl-arachidonyl-phosphatidyl choline also paradoxically deplete endothelial cholesterol, causing caveolin-1 internalization and activation of sterol regulatory element-binding protein and resulting transcription of the low-density lipoprotein receptor, while cholesterol loading reverses these effects. Results by Shentu et al. also show that, although oxLDL-induced cholesterol efflux is only 10–20% higher than basal cholesterol efflux and represents only about 1% of total membrane cholesterol, it triggers significant changes in lipid packing and cell stiffening. Thus, a small increase in cholesterol efflux leading to significant changes in lipid packing suggests that exogenous oxLDL may very selectively deplete cholesterol from specific cell membrane domains, such as caveoli and other highly ordered cholesterol-containing lipid domains.
Previous reports demonstrated increased stiffness developing in endothelial cells in response to oxLDL challenge (4). In the current study, Shentu et al. used an atomic force microscopy (AFM) approach and found that oxLDL increases endothelial elastic modulus, reflecting increased cell stiffness. An elegant confirmation of direct effects of cholesterol depletion on endothelial cell stiffness is reversal of these effects by replenishment of the membrane pool of cholesterol.
Similarly to oxLDL, 7-keto-cholesterol, the major oxysterol found in oxLDL as well as androstenol, also decreased membrane lipid packing in ordered domains and caused cell stiffening. The remaining question is whether oxysterol-induced disorganization of lipid ordered domains is the result of efflux of nonoxidized cholesterol, as it was shown in oxLDL-treated endothelial cells. These observations suggest that cholesterol oxidation is sufficient to induce endothelial stiffening associated with disruption of lipid packing of the membrane. Clearly, oxLDL-induced cell stiffening is mediated by actin cytoskeleton. Disassembly of the F-actin network by latrunculin-A abrogates the stiffening effect of cholesterol depletion (3).
The other important results of this study show a priming effect of oxLDL preconditioning on force generation of endothelial cells in three-dimensional (3D) collagen gels in the presence of PMA and growth factors. Separate assays showed oxLDL-induced stimulation of endothelial network formation. Previous studies indicate that the increased ability of endothelial cells to generate force correlates with their ability to form interconnected endothelial networks in 3D collagen gels, although the nature of such connection is not completely understood. In contrast to cholesterol depletion, hydrolysis of cell membrane-bound sphingomyelin by exogenous sphingomyelinase had no effect on basal cell stiffness and endothelial cell network formation and even decreased endothelial contractility in 3D gels.
The study by Shentu et al. convincingly demonstrates a role of disturbances in cell membrane composition and lipid order on cell contractile status. In addition, besides effects on cell membrane lipid composition, oxLDL on its own may activate the Rho/Rho-kinase-dependent mechanism of myosin light chain phosphorylation, leading to endothelial contraction and barrier dysfunction (5). Recent AFM studies show that increased cytoskeletal stiffness is associated with activation of Rho signaling leading to actomyosin assembly and force generation (1). Cholesterol-enriched lipid rafts also play a critical role in endothelial barrier protective responses via clustering or transactivation of receptors triggering Rac GTPase signaling (7). Thus, depletion of cell membrane cholesterol by oxLDL may have an additional inhibitory effect on Rac-mediated cell relaxation and enhance Rho-dependent mechanisms of actomyosin cytoskeletal reinforcement. These important relations between "agonist-like" and direct oxLDL effects on cell membrane structures and endothelial responses still remain to be investigated.
In summary, this study provides a novel insight into control of endothelial cell functions by oxLDL via alteration of cellular membrane lipid order caused by cholesterol depletion, which in turn leads to cell stiffening, force generation, and network formation. Such changes in endothelial cell environment may contribute to activated endothelial phenotype, barrier dysfunction, and pathologic vascular remodeling associated with atherosclerosis. In turn, endothelial network formation stimulated by oxLDL may represent a mechanism of neovascularization of atheromatous lesions, one of the major complications of complex lesion formation.
This work was supported by National Heart, Lung, and Blood Institute Grants HL-076259 and HL-058064.
No conflicts of interest, financial or otherwise, are declared by the author.
- Copyright © 2010 the American Physiological Society


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Monday, November 5, 2012
I Am INNOCENT! I PROMISE!
This morning the both kiddos woke up super early to see their daddy off to work. Minnie was so dazed and not quite awake. She was sitting on my lap in a chair wrapped in her favorite blanket. When Hubby left for work, I said to her, "Want to go snuggle back in my bed?"
She eyed me suspiciously and said in a slow uncertain voice, "Who is Buck?"
It took me a second to realize that she thought I had asked, "Want to go snuggle Buck in my bed?"
I assured her there was no one named Buck in my bedroom, but she was still a little nervous to go back there with me!
I have been so amused all morning by this!
2 comments:
- Kristi said...
maybe you ought to get her a little reindeer named "Buck" for Christmas... just to be sure ther eis no confusion from here on out. ;)
- November 5, 2012 at 12:44 PM
- smw said...
- November 5, 2012 at 5:15 PM
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