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A Christmas Story
A Christmas Story- (Comedy) Ralphie only wants one thing for Christmas: a Red Ryder BB gun. However, he is not sure he will ever make it to Christmas, between his brother Randy and the school bully Scut Farkus. Whenever he tells someone how much he wants it, he/she tells him that he will shoot his eye out and refuses to get it for him. A hilarious show that includes a department store Santa, Chinese Turkey, and even a "special award"!
Christmas is coming to The Barn. Come be a part of the holiday magic. America's #1 Christmas movie comes to life on our stage. Join Ralphie's quest to acquire the perfect gift, a genuine Red Ryder BB gun. Filled with quirky and lovable characters, this zany, heartfelt, and nostalgic Christmas story is a delight for young and old.
The directors of this production are not requiring a memorized prepared piece. Small pieces of the play text will be provided for the auditioning participants. Direction is given along the way and participants need not fear that they will in any way be embarrassed. Though the selection process does imply some competition, the process is made as pleasant as possible. The Barn Theatre believes in non-traditional multi-ethnic casting and encourages everyone to come out and audition.
Auditions will be held on Saturday, October 14 at The Barn Theatre in Willmar, MN
-Beginning at 3 PM
-Production dates: November 30-December 10 (Possible follow-on week)
*Note about elementary school ages: The directors will see young actors 8-14 who can "play" the appropriate ages.
Ralph Parker: older, wiser alter ego, functions as the story's narrator and various town folk
Ralphie: the young protagonist, equal parts dreamer and schemer
Randy: Ralphie's little brother
Ralphie's Mother: a patient parent with strong convictions
The Old Man: Ralphie's father, a grumpy and good hearted beleaguered patriarch
Schwartz and Flick: Ralphie's two best friends
Scutt Farkus: the schoolyard bully who routinely torments Ralphie and his friends
Grover Dill: a Farkus toady
Esther Jane and Helen: two of Ralphie's female classmates
Miss Shields: Ralphie's elementary school teacher
Why Do Fools Fall in Love? The Musical
Why Do Fools Fall in Love?- (Musical) Millie's getting married! And when three of her girlfriends (boy-crazy Sally, very shy Florence, and young tag along Dee Dee) throw her a bachelorette party, the girls end up sharing more than a great time - after tequila shots and Snowball sugar highs, they dive into the age old questions about love, marriage, and the overwhelming dating game. Featuring classic 1960s songs like "My Boy Lollipop," "I Will Follow Him," and "You Don't Have to Say You Love Me."
Sex Please, We're Sixty
Sex Please, We're Sixty- (Comedy) Mrs. Stancliffe's Rose Cottage Bed & Breakfast has been successful for many years. Her Guests (nearly all women) return year after year. Her next door neighbor, the elderly, silver-tongued, Bud "Bud the Stud" Davis believes they come to spend time with him in romantic liaisons. Her other neighbor and would-be suitor Henry Mitchell is a retired chemist who has developed a blue pill called "Venusia," after Venus the goddess of love, to increase the libido of menopausal women. Add to the guest list three older women: a romance novelist, a friend of Henry's who has agreed to test the Venusia: and a "Southern Belle" whose libido does not need to be increased!
Bye Bye Birdie: The Musical
Bye Bye Birdie- (Musical) When the draft selects rock star Conrad Birdie, his fans are devastated, but none more than struggling songwriter Albert Peterson, whose song Birdie was just about to record. Albert's longtime girlfriend, Rosie, pushes Albert to write a new tune that Birdie will perform on television to a fan selected in a contest. The scheme works, with young Ohio teenager Kim McAfee declared the winner, but no one has counted on the jealous wrath of her boyfriend…
The Three Musketeers
The Three Musketeers- (Dramatic Comedy) A tale of heroism, treachery, close escapes and above all, honor. The story, set in 1625, begins with d'Artagnan who sets off for Paris in search of adventure...along with Sabine, his sister, the quintessential tomboy. Sent with d'Artagnan to attend a convent school in Paris, she poses as a young man – d'Artagnan's servant – and quickly becomes entangled in her brother's adventures. Soon after reaching Paris, d'Artagnan encounters the greatest heroes of the day, Athos, Porthos and Aramis, the famous musketeers, and he joins forces with his heroes to defend the honor of the Queen of France. In so doing, he finds himself in opposition to the most dangerous man in Europe, Cardinal Richelieu. Even more deadly is the infamous Countess de Winter, known as Milady, who will stop at nothing to revenge herself on d'Artagnan – and Sabine – for their meddlesome behavior.
Mothers and Sons
Mothers and Sons- (Drama) At turns funny and powerful, MOTHERS AND SONS portrays a woman who pays an unexpected visit to the New York apartment of her late son's partner, who is now married to another man and has a young son. Challenged to face how society has changed around her, generations collide as she revisits the past and begins to see the life her son might have led. "Eloquent, exceptionally timely and intensely resonant. A moving reflection on a changed America." —Chicago Tribune.
The Barn Theatre
PO Box 342
321 4th St SW
Willmar, Minnesota 56201
email: firstname.lastname@example.com
design by Dennis Benson


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Refreshing with a little edge...
This is all about love, life, nature.
Stop, relax, enjoy!!
Labels: 2011, fireworks, new year, night, own photo
geplaatst door Anne / Inspire Styling @ 12:00
Happy new year to you, too. Just found you via Decor8.Leigha
A great year to you too. Hope to read more from you! (just started following your blog too)Anna
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subset: commoncrawl


text:
NAB is behind us once again and we'Äôre delighted to announce that this year'Äôs show was our most successful yet. For those of you who may have forgotten, NAB is the world'Äôs largest electronic media event and it saw more than 98,000 visitors from 159 countries making the pilgrimage to the shining lights of Las Vegas in April. The show provided us with a great platform to showcase the latest developments within Vitec Videocom and this year'Äôs highlights included several…Read More...
Time-poor but feature-rich: Sachtler Ace Accessories take the pressure out of DSLR shoots for Paul Cook.Read More >
Anton/Bauer Digital Battery Series redefines the power standard for a new generation of digital cameras.Read More >
Litepanels dazzles NAB visitors with the latest in LED technology with the newest additions to the Litepanels product range.Read More >
Sachtler's innovative accessories and camera support systems bring an added element of robustness and reliability to any shoot.Read More >


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Updates cause system crashes and freezes
So, the date us 10/15/2012. At 5 AM today I was on my computer, everything was great, etc. I turned it off, came back later today, and the first thing I notice is how long it takes to log in to my account on the computer. Before it would be at the Welcome screen for a second, now its an upwards to 15-20. Not only that, but after that screen disappears a completely black screen comes up for another 10 seconds until I finally reach my desktop. I went to movie maker, I had some editing to do with a couple of videos I used my samsung s3 to record. Everything was cool for a good 15 minutes, movie maker was a bit laggy like usual but nothing too bad. And then randomly it locked up, the screen flashed black and it said "display driver has stopped working and recovered". I thought okay wierd, but kept editing, and then randomly my PC just crashed, went to the blue screen for a dump, and restarted. This happens every time I open movie maker now. The wierd part as well was that when I went to log back in, my keyboard and mouse wouldn't work, or just the mouse, etc. I have reinstalled my video drivers, I updated my phone, I updated my computer, I'm at a loss here why this would be happening. Thanks guy any help is much appreciated
3 answers Last reply
More about updates system crashes freezes
first download this program
upload an image
There is NO free software that you need to make your system run correctly --
avoid it.
One thing is to make sure that the priority of the game is highest, there maybe other processes running that have priority over the game.
Including for instance security programs and antivirus. The latest of which have gaming modes.
If there is not a gaming mode on the security try turning it OFF.
Another good thing is to eliminate as many unused / junk / UN-needed applications.
turn off the screen saver
Go into the power profiles,
set standby, hibernate and sleep to OFF
leave the monitor standby ON, that's OK (maybe not, try OFF)
Set the Hard Drive standby to NEVER
Set system Performance to MAXIMUM, not "quiet mode."
Open the bios set up and make sure "cool and quiet" is OFF. (AMD)
There may be a performance setting in the bios setup you have...make sure it's cranked up to max.
in the bios, see that the allocation for video, if available, is maxed.
Now open the hardware manager profiles...
click start
click computer
click system properties
click device manager
double click on mice and other pointing devices
right click on HID compliant mouse
left click on properties
click on the power management tab
UN-check the box that says: "allow the computer to turn off this device to save power." (there is now NO check mark in this box)
click OK
Now repeat this procedure for all mice, monitors, keyboards, and ALL USB ports on the device manager list.
You must open ALL the devices one at a time, as above, and turn off the power saver, for each device.
You should read this: http://support.microsoft.com/kb/2674065/en-us and this: http://support.microsoft.com/kb/2673509/en-us
Ask a new question
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text:
DHAKA, Bangladesh (AP) — Police say two officers have been killed by attackers who stormed a restaurant popular with foreigners in a diplomatic zone in the Bangladeshi capital, Dhaka, taking dozens of hostages and exchanging gunfire with security forces.
Hospital authorities said another 25 officers and one civilian were being treated for injuries, including 10 people listed in critical condition. The injuries include bullet wounds and broken bones, they said.
The Islamic State's Amaq News Agency said the attack on the restaurant was carried out by "Islamic State commandos," according to the SITE Intelligence Group which monitors jihadist activity. Bangladesh authorities did not immediately respond to the claim.
As many as nine gunmen attacked the Holey Artisan Bakery in Dhaka's Gulshan area on Friday night.
(Copyright 2016 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)


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NHTSA Ratings
Based on Ford Ranger FX4 Level II
Ford continues to give compact-pickup buyers plenty of choices. Rangers are available with a four-cylinder or a choice of two V-6s, and with either a manual transmission or a five-speed automatic. Options range from skid plates and Bilstein shock absorbers to earth-shattering audio systems. Mazda... Read Full Report
What We Like
What We Don't Like
Notable Features
Average based on 29 reviewsWrite a Review
2006 2 door XLT Supercab. Bought new, my first Ranger was a used 1998. That one cost me $10,500 to drive it 198,000 miles. Had to change timing belt @100k and not enough ponies(120hp) to get me on the... Read Full Review
There are currently 5 recalls for this car.
Safety defects and recalls are relatively common. Stay informed and know what to do ahead of time.
Service & Repair


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So, you may be wondering…
Helping over 700 start-up catering businesses each year, NCASS is a trade association for caterers and suppliers in the UK and Ireland.
The organisation aims to "provide caterers with information, systems and support whilst helping them be safe, legal and profitable".
To view NCASS' membership packages, click on one of the links below, depending on whether you're a mobile caterer or work from a fixed site:
1. Mobile and function caterers
Prices start at £21 a month and vary depending on what package you chose.
The main difference between the packages is the number of places they offer on training courses.
The training courses include: Hygiene (levels 1 to 3), Health & Safety, First Aid, Fire Extinguisher and HACCP.
As well as free places on the training courses listed above, as a catering member you receive half price places on a Sustainability Training course (normally priced at £95).
The course was developed by NCASS, in association with the Sustainable Restaurant's Association (SRA) and addresses three concepts of sustainability:
(1) Sourcing food (2) Social responsibility and (3) Environmental practices
The course is all online and takes up to 3 hours. And if you pass the 20 minute online exam, you'll receive a "stylish A4 colour certificate, laminated for display in the kitchen". 🙂
As well as taking NCASS' Sustainability course, why not green your catering business by switching to sustainable food packaging?
Regular disposable packaging is often made from plastic. Plastics are made from oil. Plus lots of plastics can't be recycled.
To ensure your business isn't using up resources or contributing to landfill, opt for our…
1. Revive™ food packaging. It's all widely recyclable and even the materials used are recycled. So when you're offering a salad in Revive™ container, you can tell your customers the container was made by recycling old water bottles.
Alternatively, choose our…
2. Sustain™ food packaging. It's all compostable and made from plants. For example, instead of oil-based plastic, Sustain™ cups are made of bio-plastic, which is made from corn.
You receive…
√ A subscription to the Catering Quarterly Magazine. Our food packaging featured in the summer edition!
√ Your own profile page on the NCASS website – check out our page here.
√ Exclusive discounts. Our most recent offer (15% off our food packaging) has just ended, but keep your eyes peeled for future offers.
(To see all the member benefits, view the NCASS site!)
And now, for a pic of our NCASS certificate…


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Hungry For Success, Stan Wawrinka Knows His Limits
At the age of 33, Switzerland's Stan Wawrinka will be first to say that he is no spring chicken on the men's tour.
The three-time grand slam champion is currently positioned third in the world, equalling his career best. Known as a player that shines on some of the biggest stages in tennis, this year is Wawrinka's 15th on the tour. His longevity might not be as outstanding as him teammate Roger Federer, but the current US Open champion as at peace with that.
"I think what roger does has always been different to other players. He is a unique player. He has a unique mentality." Wawrinka explained.
Last year Wawrinka became the oldest winner at Flushing Meadows since Ken Rosewall in 1970. Since turning 29, he has finished three consecutive seasons ranked inside the top-5, winning at least one grand slam title. Wawrinka's late blossom is something others aspire to, but the 32-year-old knows when he has reached his limits.
" I think so far has been good over the past ten years. I don't try to play too much and take breaks during the season." He said
"I think getting older it is more important to be careful."
'I enter the court to try to win'
The latest task in Wawrinka's career is this week's Monte Carlo Masters. Seeded third in the tournament, he overcame a second set blip to dismiss Jiri Vesely 6-2, 4-6, 6-2, on Wednesday. The victory saw the Swiss player hit 32 winners alongside 20 unforced errors. Wawrinka's reward is a quarterfinal showdown against Pablo Cuevas in what will be their first tour meeting.
"He's a great player, a tough player, especially on the clay." Wawrinka said about Cuevas." I've practice with him a few times and it's never been easy. So it's going to be an interesting match."
Wawrinka's singles success comes as he crashed out in the doubles draw. Paired with Italy's Fabio Fognini, the two lost in straight sets to second seeds Nicolas Mahut and Pierre-Hugues Herbert. It was a case of what could have been for the Swiss/Italian duo, who squandered a 5-3 lead in the opening set.
"I did enjoy playing with him (Fognini), he's a good friend in general. It was a great experience it was really nice." Wawrinka said of his doubles experience in Monte Carlo.
With singles as his primary focus, it could be forgiven to expect Wawrinka to not be fully engaged in the doubles competition. Nevertheless, the world No.3 plays to win regardless of what he is participating in.
"When I enter the court I try to win. That is what we tried today (in the doubles). We had some chances in the first set, didn't take it and that's it."
Wawrinka will play Cuevas in the second match on Court Rainier III on Thursday.


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Surgical Research
Surgical Research
News Article | April 27, 2017
Site: www.eurekalert.org
Vanderbilt University Medical Center (VUMC) cancer researcher James Goldenring, M.D., Ph.D., has received a two-year, $200,000 grant from the DeGregorio Family Foundation in Pleasantville, New York, to begin clinical trials of a potential approach for reversing precancerous stomach lesions. Stomach cancer is the fourth leading cause of cancer-related deaths worldwide after lung, liver and colorectal cancers. In the United States, 28,000 people will be diagnosed with stomach cancer this year, and nearly 11,000 will die from the disease, according to the American Cancer Society. Goldenring said the grant will support an international collaborative trial with colleagues at Yonsei University Medical Center in Seoul, Korea, to test the effectiveness of the drug Selumetinib to reverse pre-cancerous lesions in patients following endoscopic resection of stage I gastric cancer. Koreans have one of the world's highest incidences of gastric cancer. "I am extremely grateful for the support that we have received from the DeGregorio Family Foundation," said Goldenring, the Paul W. Sanger Professor of Experimental Surgery at Vanderbilt University School of Medicine. "It is often difficult to obtain support for trials that require clinical collaboration at international sites." "We are very excited to partner with Dr. Goldenring and his colleagues at Vanderbilt University," said Lynn DeGregorio, president of the DeGregorio Family Foundation. "We look forward to the day when we can say we had a part in eradicating stomach cancer." The foundation was established in 2006 after a 10th member of the DeGregorio family succumbed to stomach cancer and was found to have had a rare gene mutation that causes the disease and other common cancers. Selumetinib blocks MEK, an enzyme downstream of Ras, a signaling protein that regulates cell growth and survival. Abnormal Ras activation, possibly triggered by other signaling molecules, is associated with up to one-third of all human cancers and recently was identified in a large percentage of gastric cancers. A year ago, Goldenring reported in Gastroenterology that Selumetinib, a drug recently approved for use in patients with advanced thyroid cancer, halted and reversed neoplastic progression in a mouse model of activated Ras induction of metaplasia and precancerous lesions in the stomach. It appears that underneath the abnormal metaplastic cells hides a lineage of normal progenitor cells, which can regenerate the normal mucosal layer of the stomach, Goldenring said. When the consequences of abnormal Ras activation were blocked by Selumetinib, normal cells pushed the abnormal tissue out of the mucosa. The grant will support a study of MEK inhibition in patients who have had local endoscopic removal of a stage I gastric cancer. These patients have a 2 to 5 percent per year incidence of developing a second cancer in the stomach because a large amount of metaplastic mucosa remains. Astra-Zeneca Corporation will provide the Selumetinib for the trial. Few clinical trials have focused on the elimination of discrete precancerous cells through drug treatment, Goldenring said. The protocol for treatment with Selumetinib will evaluate the drug's efficacy for resolving pre-cancerous metaplasia in humans. If short-term treatment with Selumetinib is successful in these patients, broader studies will be needed to evaluate the consequences on both cancer recurrence and long-term survival, he said. Goldenring is professor of Surgery and Cell & Developmental Biology, vice-chair for Surgical Research in the Section of Surgical Sciences and co-director of the Epithelial Biology Center at VUMC. He also is a staff physician at the Veterans Affairs Medical Center (Tennessee Valley Healthcare System, Nashville campus).
Xie H.-H.,Shanghai University |
Xie H.-H.,University of Pittsburgh |
Zhou S.,Shanghai University |
Zhou S.,University of Pittsburgh |
And 7 more authors.
Hypertension | Year: 2010
Endothelial progenitor cells (EPCs) are both reduced and dysfunctional in hypertension that correlates inversely with its mortality, but the mechanisms are poorly understood. Endothelial nitric oxide synthase (eNOS) critically regulates EPC mobilization and function but is uncoupled in salt-sensitive hypertension because of the reduced cofactor tetrahydrobiopterin (BH4). We tested the hypothesis that GTP cyclohydrolase I (GTPCH I), the rate-limiting enzyme of BH4 de novo synthesis, protects EPCs and its function in deoxycorticosterone acetate (DOCA)-salt mice. EPCs were isolated from peripheral blood and bone marrow of wild-type (WT), WT DOCA-salt, endothelial-specific GTPCH transgenic (Tg-GCH), GTPCH transgenic DOCA-salt, and BH4-deficient hph-1 mice. In WT DOCA-salt and hph-1 mice, EPCs were significantly decreased with impaired angiogenesis and adhesion, which were restored in Tg-GCH DOCA-salt mice. Superoxide (O2) and nitric oxide (NO) levels in EPCs were elevated and reduced, respectively, in WT DOCA-salt and hph-1 mice; both were rescued in Tg-GCH DOCA-salt mice. eNOS-/-GCH+/- hybrid mice demonstrated that GTPCH preserved the circulating EPC number, reduced intracellular O2 in EPCs, and ameliorated EPC dysfunction independent of eNOS in DOCA-salt hypertension. Secreted thrombospondin-1 (TSP-1; a potent angiogenesis inhibitor) from EPCs was elevated in WT DOCA-salt and hph-1 but not DOCA-salt Tg-GCH mice. In vitro treatment with BH4, polyethylene glycol-superoxide dismutase (PEG-SOD), or Nomega-nitro-L-arginine (L-NNA) significantly augmented NO and reduced TSP-1 and O2 levels from EPCs of WT DOCA-salt mice. These results demonstrated, for the first time, that the GTPCH/BH4 pathway critically regulates EPC number and function in DOCA-salt hypertensive mice, at least in part, via suppressing TSP-1 expression and oxidative stress. © 2010 American Heart Association, Inc.
PubMed | Sun Yat Sen University, Surgical Research, Shanghai JiaoTong University, University of California at Davis and University of Pittsburgh
Type: Journal Article | Journal: The Journal of biological chemistry | Year: 2015
Estrogen sulfotransferase (EST) regulates estrogen homeostasis by sulfonating and deactivating estrogens. Liver ischemia and reperfusion (I/R) involves both hypoxia during the ischemic phase and oxidative damage during the reperfusion phase. In this report, we showed that the expression of EST was markedly induced by I/R. Mechanistically, oxidative stress-induced activation of Nrf2 was responsible for the EST induction, which was abolished in Nrf2(-/-) mice. EST is a direct transcriptional target of Nrf2. In female mice, the I/R-responsive induction of EST compromised estrogen activity. EST ablation attenuated I/R injury as a result of decreased estrogen deprivation, whereas this benefit was abolished upon ovariectomy. The effect of EST ablation was sex-specific because the EST(-/-) males showed heightened I/R injury. Reciprocally, both estrogens and EST regulate the expression and activity of Nrf2. Estrogen deprivation by ovariectomy abolished the I/R-responsive Nrf2 accumulation, whereas the compromised estrogen deprivation in EST(-/-) mice was associated with increased Nrf2 accumulation. Our results suggested a novel I/R-responsive feedback mechanism to limit the activity of Nrf2 in which Nrf2 induces the expression of EST, which subsequently increases estrogen deactivation and limits the estrogen-responsive activation of Nrf2. Inhibition of EST, at least in females, may represent an effective approach to manage hepatic I/R injury.
PubMed | Sun Yat Sen University, China Pharmaceutical University, Surgical Research, Zhejiang University and 3 more.
Type: | Journal: Nature communications | Year: 2015
Sepsis is the hosts deleterious systemic inflammatory response to microbial infections. Here we report an essential role for the oestrogen sulfotransferase (EST or SULT1E1), a conjugating enzyme that sulfonates and deactivates estrogens, in sepsis response. Both the caecal ligation and puncture (CLP) and lipopolysaccharide models of sepsis induce the expression of EST and compromise the activity of oestrogen, an anti-inflammatory hormone. Surprisingly, EST ablation sensitizes mice to sepsis-induced death. Mechanistically, EST ablation attenuates sepsis-induced inflammatory responses due to compromised oestrogen deactivation, leading to increased sepsis lethality. In contrast, transgenic overexpression of EST promotes oestrogen deactivation and sensitizes mice to CLP-induced inflammatory response. The induction of EST by sepsis is NF-B dependent and EST is a NF-B-target gene. The reciprocal regulation of inflammation and EST may represent a yet-to-be-explored mechanism of endocrine regulation of inflammation, which has an impact on the clinical outcome of sepsis.
News Article | December 10, 2015
Site: www.biosciencetechnology.com
A team of UCLA researchers found that there are several parts of California where, in a high percentage of people with thyroid cancer, the disease is already at an advanced stage by the time it is diagnosed. The research was led by Dr. Avital Harari, a member of the UCLA Jonsson Comprehensive Cancer Center and assistant professor of surgery. Approximately 63,000 people were diagnosed with thyroid cancer nationwide last year, and according to the National Cancer Institute, the incidence of thyroid cancer has increased across racial, ethnic and gender lines over the past several decades. When detected early, thyroid cancer is treatable and even curable. However, survival rates are much lower for people who are diagnosed at advanced stages of the disease. The UCLA scientists examined county-by-county data from the California Cancer Registry for 27,000 people who had been diagnosed with thyroid cancer from 1999 to 2008. To ensure that they were comparing similar population sizes, the researchers grouped together some smaller counties for the analysis. Nationally, about 29 percent of people with thyroid cancer have advanced-stage disease by the time it is diagnosed, according to data from the NCI's surveillance, epidemiology, and end results program, also known as SEER. Of the 47 geographical areas the UCLA researchers analyzed, 20 had significantly higher percentages than that, ranging from 33 percent (Orange County) to 51 percent (for the combination of Alpine, Amador and Calaveras counties). Overall, in 35 percent of Californians with thyroid cancer — 6 percentage points higher than the national average — the disease has reached the regional and/or distant metastatic stage, meaning that it has spread beyond the thyroid to other tissues in the neck, regional lymph nodes or other parts of the body, by the time it is diagnosed. According to the UCLA findings, the California counties (or combined county groups) where people were most likely to have advanced thyroid cancer at the time of diagnosis were: Alpine, Amador and Calaveras (combined): Disease was advanced in 51 percent of those with thyroid cancer Imperial: 48 percent Sutter: 45 percent San Francisco: 41 percent Santa Barbara: 40 percent Southern California counties outside of the top five were San Bernardino, which ranked 12th (37 percent of people with thyroid cancer had advanced-stage disease), San Diego (13th, 36 percent), Los Angeles (14th, 35 percent), Fresno (17th, 34 percent), Ventura (18th, 34 percent) and Orange (20th, 33 percent). The counties with the highest percentages of people with advanced cancer were not grouped together in any obvious geographic pattern, meaning that none of the larger regions within the state seem to have a higher risk for the disease than any other. Harari said it is not clear why the incidence of advanced-stage thyroid cancer is that much higher in California than the national average, but her research suggests there might be an environmental component. "California has the largest amount of farmland in the country, so this type of exposure could very well contribute to our thyroid cancer rates," she said. However, the only known environmental risk factor for thyroid cancer is radiation exposure, and that alone is unlikely to fully explain the phenomenon. The next stage of Harari's research will evaluate possible links between thyroid cancer and exposure to pesticides and radon. The study was published online by the Journal of Surgical Research.
News Article | December 7, 2016
Site: www.prweb.com
A new study published in the just-published "Oncotarget" peer-reviewed medical journal has concluded that "in the setting of previously treated, advanced pancreatic cancer, liquid biopsies are not yet an adequate substitute for tissue biopsies. Further refinement in defining the optimal patient population and timing of blood sampling may improve the value of a blood-based test." The study was conducted by a team of researchers and clinicians from Perthera, Inc., a precision medicine company based in McLean, VA, the Pancreatic Cancer Action Network (PanCAN), Lombardi Comprehensive Cancer Center of Georgetown University, Cedars-Sinai Medical Center, Ohio State University, City of Hope Cancer Center, Virginia Mason Medical Center, and the Sidney Kimmel Cancer Center at Thomas Jefferson University. The study is entitled "a pilot study evaluating concordance between blood-based and patient-matched tumor molecular testing within pancreatic patients participating in the Know Your Tumor (KYT) Initiative." Know Your Tumor is a benchmark precision cancer therapy program of the Pancreatic Cancer Action Network that is executed by Perthera. The study asserted that "molecular profiling of the tumor itself should remain the gold standard," or as approved by the FDA. Liquid biopsies can "go wrong" in a variety of ways: mainly because the tumor isn't dumping DNA into the blood, or because the detection assays aren't sensitive enough to detect the DNA when it is too low in abundance to see. The investigators assessed the ability of the circulating genomic information obtained from a blood sample of 34 consecutively screened pancreatic cancer patients with metastatic disease to accurately recapitulate the genomic information obtained by direct analysis of a tumor biopsy obtained from the same patient taken at the same time. They used the high frequency of KRAS mutation (~90%) in pancreatic cancer as a benchmark for comparison, and they found that KRAS mutations "were only detected in 10/34 (29%) blood samples, compared to 20/23 (87%) tumor tissue biopsies." Dr. Jonathan Brody, the last author on the study and Director of Surgical Research and Co-director of the Jefferson Pancreas, Biliary and Related Cancer Center and on the scientific advisory board at Perthera, cautioned that "the results of this study should give people some pause; we need to be very careful about the state of the liquid biopsy field right now." He said, "we need to be very circumspect- in this study, we detected DNA with KRAS mutations in only a third of the patients that you should see the genomic alteration, so what does it say about being able to reliably detect actionable alterations that doctors would use to make critical treatment decisions?" Dr. Michael Pishvaian, the first author of the study and Perthera's CMO as well as the Director of the Phase I Clinical Program and Co-Director of the Ruesch Center Pancreatic Cancer Program at Georgetown University added that "there will be times when a tumor biopsy is unable to be performed due to medical issues, and then could a liquid biopsy be considered. Pishvaian says: "There are papers that show good but not perfect concordance between the genomic information in tumor samples and blood samples, and our study in pancreatic cancer reveals something different. Some of the disparate results from these studies come from differences in the clinical aspects of the patients studied, but ultimately if liquid biopsies are to be used routinely for precision medicine applications then the field needs more improvements." In the meantime, Emanuel "Chip" Petricoin, PhD, Perthera's Chief Science Officer said, "Central to Perthera's medical philosophy is that the patient should have as extensive molecular profiling as relevant, and blood-based testing will be great to add to our arsenal of testing options as it becomes more reliable and sensitive. So, we are committed to implementing molecular profiling technologies that have the best evidence of impact to patients' precision cancer therapy outcome and we will be constantly monitoring the state of the field on this topic. As the liquid biopsy technologies and approaches improve and become more sensitive, then we can validate them and implement them." ABOUT PERTHERA, INC.: Perthera is a founder- and venture-backed precision medicine company based in McLean, VA, that has achieved more than 1,000 case histories since it was founded about five years ago, often working in an alliance with cancer advocacy agencies as well as hospitals, community oncology practices, and academia. In every patient instance, the Company seeks to become the precision medicine partner on their cancer care team, providing the widest, deepest, and most independent range of service possible.
News Article | February 15, 2017
Site: www.marketwired.com
MONTREAL, QUEBEC--(Marketwired - Feb. 10, 2017) - Relevium Technologies Inc. (TSX VENTURE:RLV)(FRANKFURT:6BX) (the "Company" or "Relevium") a consolidator of e-commerce assets in Health and Wellness in conjunction with its board of directors, is pleased to announce the addition of Dr. Tina Sampalis to the Company's Board of Directors. Tina Sampalis, M.D., Ph.D., is an oncology surgeon trained in physiology at McGill University in Montreal, medicine at the University of Patras (Greece), dermatology at Göttingen University (Germany) and Marselisborg University (Denmark), pediatric, general and oncology surgery at the University of Athens (Greece), graduate training (Ph.D.) in Surgical Research at the University of Athens and a second Ph.D. in Epidemiology and Experimental Surgery at McGill University. Dr. Sampalis' leading work in Nutraceuticals includes Neptune Technologies & Bioressources, where she discovered one of the primary reasons krill oil is so beneficial to human health: Phospholipids. Dr. Sampalis is the named inventor of Neptune's composition and application patents. As the former President of Acasti Pharma Inc. she led the development of a novel patented active pharmaceutical ingredient targeting the prevention and treatment of hypertriglyceridemia and cardio metabolic-disorders. She is the Founder and President of the AGOO Children's Health & Wellness Center, a state-of-the-art multidisciplinary comprehensive, pediatric-adolescent medical center and accredited McGill University teaching site in Quebec. Dr. Sampalis has received several international scholarships and awards for her work on the clinical implementation of retinols for skin and breast cancer, including the Helen Hutchison Award for geriatric medicine. Her work on scintimammography resulted in her appointment at the International Educational Speakers Bureau, the Canadian and U.S. Faculty of Medical Speakers for Breast Imaging. As an international scholar, Dr. Sampalis leads the development and implementation of innovative micro-invasive and stereotactic robotic surgical techniques for breast cancer, for which a U.S. and Canadian patent application has been filed. She is a member of the American Association of Naturopathic Medicine. Dr. Sampalis has published papers in multiple peer-reviewed publications. She was named one of the 10 most successful women in Quebec (Les Affaires, 18-24 September 2010) and one of the 100 most successful globally by the Princeton Global Network. Relevium Technologies Inc. (TSX.V - "RLV") President and CEO, Aurelio Useche, stated, "We are very honored to have Dr. Sampalis join our Company. The addition of Dr. Sampalis closes the value chain by providing deep expertise in scientific and evidence based nutraceutical and medical trends, which can be leveraged through the consolidation of e-commerce assets such as BioGanix as announced on December 22, 2016." Relevium is a TSX Venture listed issuer focused on growth through the acquisition of businesses, products and/or technologies with a focus on e-commerce in the growing health and wellness sector, specifically under three important verticals: Pain Relief, Recovery and Performance. Relevium Technologies Inc. currently holds patented intellectual property for application of static magnetic fields on direct-to-consumer devices, which aid in decreasing pain, improving recovery time and enhancing overall physical performance. BioGanix (http://www.bioganix.com/) was founded with customer results in mind, to provide the best quality, best researched, and most potent formulas at competitive prices, while providing excellent and personal customer care. BioGanix puts our customers first, and do everything we can to keep them happy. BioGanix prides itself on using only the best and purest ingredients in our manufacturing processes. BioGanix only provides premium quality products, and doesn't cut any corners in manufacturing processes. All BioGanix products have been 3rd Party Laboratory tested and verified, and are manufactured in GMP Certified and FDA inspected facilities in the USA. BioGanix currently has over 16 of the best-selling dietary supplement products available, varying from trending weight loss products, to proven health supporting supplements that supports various processes in the body, including digestive health, heart health, brain health, blood sugar, as well as anti-aging supplements. Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release. This release includes certain statements and information that may constitute forward-looking information within the meaning of applicable Canadian securities laws or forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995. All statements in this news release, other than statements of historical facts, including statements regarding future estimates, plans, objectives, assumptions or expectations of future performance, including the timing and completion of the proposed acquisitions, are forward-looking statements and contain forward-looking information. Generally, forward-looking statements and information can be identified by the use of forward-looking terminology such as "intends" or "anticipates", or variations of such words and phrases or statements that certain actions, events or results "may", "could", "should", "would" or "occur". Forward-looking statements are based on certain material assumptions and analysis made by the Company and the opinions and estimates of management as of the date of this press release, including the assumptions that the Company will obtain stock exchange approval of the Offering, the proposed acquisition will occur as anticipated, that the Company will raise sufficient funds, and that the Company will obtain all requisite approvals of the acquisition. These forward-looking statements are subject to known and unknown risks, uncertainties and other factors that may cause the actual results, level of activity, performance or achievements of the Company to be materially different from those expressed or implied by such forward-looking statements or forward-looking information. Important factors that may cause actual results to vary, include, without limitation, the risk that the proposed acquisitions may not occur as planned; the timing and receipt of requisite approvals and failure to raise sufficient funds under the Offering. Although management of the Company has attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking statements or forward-looking information, there may be other factors that cause results not to be as anticipated, estimated or intended. There can be no assurance that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking statements and forward-looking information. Readers are cautioned that reliance on such information may not be appropriate for other purposes. The Company does not undertake to update any forward-looking statement, forward- looking information or financial outlook that are incorporated by reference herein, except in accordance with applicable securities laws. We seek safe harbor. On Behalf of the Board of Directors
Dehne N.,Goethe University Frankfurt |
Kerkweg U.,Institute of Physiological Chemistry |
Flohe S.B.,Surgical Research |
Brune B.,Goethe University Frankfurt |
Fandrey J.,University of Duisburg - Essen
Shock | Year: 2011
Skeletal muscle damage provokes complex repair mechanisms including recruitment of leukocytes as well as activation of myogenic precursor cells such as satellite cells. To study muscle cell repair mechanisms after muscle fiber damage, we used an in vitro model of scrape-injured myotubes. Exposing vital C2C12 myoblasts and myotubes to cell debris of damaged myotubes revealed mRNA upregulation of adrenomedullin (ADM), insulin-like growth factors 1 and 2, metallopeptidase 9, and monocyte chemoattractant protein11. When cell debris was treated with ultrasound, frozen in liquid nitrogen, or heat inactivated before addition to C2C12 cells, gene expression was drastically reduced or completely absent. Moreover, incubations of myoblasts with debris separated by transwell inserts indicated that direct cell contact is required for gene induction. Incubation with albumin and PolyIC ruled out that ADM induction by cell debris simply results from increased protein or nucleic acid concentrations in the supernatant. Because the genes, which were upregulated by cell debris, are potential target genes of hypoxia-inducible factor (HIF), cells were analyzed for HIF-1α expression. Western blot analysis showed accumulation of the α-subunit upon contact to cell debris. Knockdown of HIF-1α in C2C12 cells proved that activation of HIF-1 in response to cell debris was responsible for upregulating ADM and monocyte chemoattractant protein 1. Furthermore, by incubating cells on gas-permeable culture dishes, we excluded a reduced pericellular pO2 induced by cell debris as the cause for ADM upregulation. Our data suggest that damaged myofibers activate HIF-1 in neighboring myotubes and precursor myoblasts by direct contact, concomitantly upregulating factors necessary for angiogenesis, tissue regeneration, and phagocyte recruitment. Copyright © 2011 by the Shock Society.
Kaczorowski D.J.,University of Pittsburgh |
Afrazi A.,University of Pittsburgh |
Scott M.J.,University of Pittsburgh |
Kwak J.H.,University of Pittsburgh |
And 7 more authors.
Journal of Leukocyte Biology | Year: 2010
TLRs and complement are critical to the host response in sepsis, trauma, and ischemia/reperfusion. We hypothesize that TLR stimulation leads to synthesis and release of complement components by macrophages, an important source of extrahepatic complement. RAW264.7 macrophages or peritoneal macrophages from WT and TLR4-, TLR3-, TRIF-, or MyD88-deficient mice were cultured under standard conditions. In some experiments, cells were pretreated with inhibitors of MAPKs or a NF-κB inhibitor. Cells were stimulated with TLR ligands at known stimulatory concentrations. Intratracheal and i.p. injections were also performed in mice. RT-PCR, Western blotting, and immunocytochemistry were used for analysis. Using a RT-PCR-based panel, we demonstrate that of 18 complement components tested, factor B of the alternative pathway is the most robustly up-regulated complement component in macrophages in response to LPS. This up-regulation results in release of factor B into the media. Up-regulation of factor B by LPS is dependent on TLR4, TRIF, JNK, and NF-κB. A screen of other TLR ligands demonstrated that stimulation with poly I:C (dsRNA analog) also results in up-regulation of factor B, which is dependent on JNK and NF-κB but independent of TLR3 and TRIF. Up-regulation of factor B is also observed after intratracheal and i.p. injection of LPS or poly I:C in vivo. PRR stimulation profoundly influences production and release of factor B by macrophages. Understanding the mechanisms of PRR-mediated complement production may lead to strategies aimed at preventing tissue damage in diverse settings, including sepsis, trauma, and ischemia/reperfusion. © Society for Leukocyte Biology.
Sun Q.,University of Pittsburgh |
Gao W.,University of Pittsburgh |
Loughran P.,University of Pittsburgh |
Shapiro R.,University of Pittsburgh |
And 4 more authors.
Journal of Biological Chemistry | Year: 2013
Caspase 1 activation can be induced by oxidative stress, which leads to the release of the proinflammatory cytokines IL1β and IL18 in myeloid cells and a potentially damaging inflammatory response. However, little is known about the role of caspase 1 in non-immune cells, such as hepatocytes, that express and activate the inflammasome but do not produce a significant amount of IL1β/IL18. Here we demonstrate that caspase 1 activation protects against cell death after redox stress induced by hypoxia/reoxygenation in hepatocytes. Mechanistically, we show that caspase 1 reduces mitochondrial respiration and reactive oxygen species by increasing mitochondrial autophagy and subsequent clearance of mitochondria in hepatocytes after hypoxia/reoxygenation. Caspase 1 increases autophagic flux through up-regulating autophagy initiator beclin 1 during redox stress and is an important cell survival factor in hepatocytes. We find that during hemorrhagic shock with resuscitation, an in vivo mouse model associated with severe hepatic redox stress, caspase 1 activation is also protective against liver injury and excessive oxidative stress through the up-regulation of beclin 1. Our findings suggest an alternative role for caspase 1 activation in promoting adaptive responses to oxidative stress and, more specifically, in limiting reactive oxygen species production and damage in cells and tissues where IL1β/IL18 are not highly expressed. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.


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Low tide for those that once caught a wave
As a teenager I remember weekend wear for blokes generally fell into two camps - the cool dudes wore Billabong and Quiksilver boardies and the not so cool, but ever so practical guys wore stubbies, jeans and cords. Surf gear was trendy and it commanded a price premium for its "cool" factor.
It has been sad to watch Billabong "wipeout" over the past 12 months, with a collapsing share price, declining earnings, two failed takeover bids as prospective buyers walked away, and now the very real prospect that the business might not survive. How can such an iconic brand go so wrong?
There are all sorts of explanations for what has gone wrong for Billabong over the past decade. The company was founded on the Gold Coast in 1973 by Gordon Merchant who is still a significant shareholder today. He created triple-stitched board shorts that surfies liked as they didn't come apart during tricky board manoeuvres.
Billabong garments were soon exported around the world, and when the surfing industry took off in the 1990s, Billabong became a significant player.
Arguably the company's first mistake was its rapid expansion through acquisition. Throughout the 1990s and 2000s, the company acquired new brands and retail outlets (largely debt financed), at one point announcing four acquisitions in the space of four months.
Initially the company's growth strategy worked and in 2000 when the company listed on the Australian Stock Exchange it had sales of $225 million, growing to $1.7 billion in 2011. Profits peaked at $249m in 2007.
But the summer weather didn't last. The company didn't adapt to a changing market landscape and lost its relevance with its core market - surfers. Newcomers who were more in touch with Billabong's traditional customers arrived on the scene and captured market share. Surf shops consolidated and retailers picked and chose the brands they wanted to sell. In the late 2000s Billabong had an extensive portfolio of brands and its debt burden made it difficult to respond to competitor activity.
By the time the bankers came calling last year as the company breached its financial covenants, the company was on its knees. It has been a steep slide for a company that five years ago was a A$4b ($4.74b) company with a share price of A$14.
After the second potential bidder walked away (leaving investors wondering just what they found when they looked under the hood), the share price tumbled to just A$0.15 and the company is now worth under A$100m.
It now seems the company will be forced to sell a substantial chunk of its assets to alleviate its debt burden and try to turn its fortunes around.
This job will be hard enough, but made even worse by the recent earnings result from competing firm Quiksilver, which was founded four years before Billabong and is listed on the New York Stock Exchange.
Quiksilver missed its earnings projections and said it intends to sell assets and inventory to turn its fortunes around.
Looks like we're going to be bombarded with cheap boardies and T-shirts. Good news for teenagers.
Carmel Fisher is managing director of Fisher funds, an investment manager and KiwiSaver provider.
Sunday Star Times


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Oxford English Dictionary Adds 'Woke,' 600 Other Words to Its Vocabulary
By Erica Abbott
PublicDomainPictures / Pixabay
The Oxford English Dictionary has added a plethora of new words to their online database. Those searching their dictionary can now find the definitions of words such as "woke," "hygge" and "post-truth," which they named last year's Word of the Year.
One of the most notable entries for many on social media was "woke," a slang entry that was met with both praise and backlash. The Oxford English Dictionary defines "woke" as:
well-informed, up-to-date. Now chiefly: alert to racial or social discrimination and injustice; frequently in stay woke (often used as an exhortation).
In later use perhaps popularized through its association with African-American civil rights activism (in recent years particularly the Black Lives Matter movement), and by the lyrics of the 2008 song Master Teacher by American singer-songwriter Erykah Badu, in which the words I stay woke serve as a refrain.
In addition to having an original meaning of simply "awake," the adjectival "woke" has been around far longer than some may think. According to Oxford Dictionaries, the earliest use in a figurative sense was in a 1962 New York Times article. Titled "If You're Woke, You Dig It," it "describes how white beatniks were appropriating black slang at the time." The term is now widely used to challenge others to be more aware of injustices in the world.
This was just one of the 600 words the online dictionary added to its database this quarter. Other words that captured the attention of the internet were "Zyzzyva," which is now the dictionary's newest last word, and "post-truth"—which deals with how people's emotions and personal beliefs may shape public opinion more than objective facts. It was named their 2016 Word of the Year in November due to Brexit and the contentious presidential election in the U.S.
Other new word entries include:
- bug chaser
- casita
- chantoosie
- devil dog
- gingerish
- sonification
- unlaughing
- unlawyerly
- Webby
- zoomable
- zoophagy
See how social media reacted to the new words and definitions below:
Social Media Reacts to Oxford English Dictionary's New Word Entries
Not sure @OED' new definition of 'woke' is woke enough. https://t.co/6zwBXmoJWa pic.twitter.com/yyLx5Nisrk
— Ari Phillips (@re_ari) June 27, 2017
What a thing is this post-truth thing! https://t.co/vGybZOpS3F
— Dinesh Sinha (@dinesh2sinha) June 26, 2017
"Woke" and "post-truth" have been added to the @OED… so sad.
— arielegivner (@arielegivner) June 27, 2017
'Wokeness' has found it's way to Oxford Dictionary
— Ogens (@ogens2) June 27, 2017
Woke has been added to the Oxford dictionary. Yayy millenials.
— El Capitán (@pyrate_lord) June 27, 2017
Lmao "woke" was added to the Oxford Dictionary #StayWoke
— Kristina Airdo (@kristina_airdo) June 26, 2017
Want to sound more educated? Well I've got some good news for you! The @OxfordWords dictionary has added 'Woke' and 'Post-Truth' #StayWoke
— Robert Jimison (@CNNRobert) June 27, 2017
Which new Oxford English Dictionary entry is your favorite? Do you like that they added "woke" to their online dictionary? Sound off in the comments section below!
Source:: Business 2 Community


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Fixmykite.com Microhook Braiding Tool$12.00
Naish Smartloop Chickenloop complete with Trimline. industry standard push away safety release.
The Naish Chickenloop is the standard quick release on the 2015 and 2016 Fusion bars. This replacement chickenloop can be used to repair a current bar or used to retrofit a customer bar with the latest push-away safety system.
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Ideal for a wide variety of freeride, freestyle and wave riding, the 2016 Naish Fusion 4-Line Control System provides a function-rich design for an exciting, secure and seamless riding experience. The 2016 Naish Fusion bar has equal line lengths so it should work with most modern-day kites.
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The emergency services were called to the Plough roundabout on Preston New Road this Afternoon, Friday 31 July.
Two vehicles collided at the roundabout at around 1.40pm.
Ambulance crews checked the occupants at the scene. There did not appear to be any serious injuries.
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Words containing dopm
Found 3 words containing dopm. Browse our Scrabble Word Finder, Words With Friends cheat dictionary, and WordHub word solver to find words that contain dopm. Or use our Unscramble word solver to find your best possible play! Related: Words that start with dopm, Words that end in dopm
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"Texas manufacturing activity remained sluggish in March," according to the monthly business activity survey conducted by the Federal Reserve Bank of Dallas, released yesterday.
The general business conditions index dipped to negative 22.7 in March from negative 21.4 in February.
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There might be a worldwide agreement that children are obliged to provide care to their elderly parents. However, the manner in which this value manifests itself is rather diverse in different countries.
Researchers analyzed the circumstances in which the financial, emotional or instrumental help is given to the parents by their children across European countries. The study used data from the generations and gender surveys conducted in Bulgaria, the Czech Republic, Georgia, Lithuania, Poland, Romania, Russia, France and Norway.


text:
I am Benjamin Riexinger
I am a versatile professional with more than five years of experience in which I always exceed the expectations of my customers and employer. I have proven excellence in diagnosis of electrical and computer system, physical & digital security of confidential information systems, employee supervision, and team leadership. My versatile background and analytical approach to problem solving allows me to successfully work across all levels of an organization. My technical abilities have led to various improvements some of which have allowed for a decrease in man hours required to complete day-to-day tasks, as well as increase my organization's ability to audit and manage personnel. With my incredible documentation and in-depth training program I am able to set my staff on a path of excellence professionally and have them deliver exemplary customer service. Under my leadership the State University of New York at Buffalo Computing and Information Technology Public Sites Consulting Team has met our students demand for computing and printing services with unprecedented customer service and satisfaction.
A Computer Science Major at the University at Buffalo.
Email: email@example.com
CC Number: 5487-8563-2145-9562
Expiration Date: 08/20


text:
Copacabana Beach Guide
Known as the world's most famous beach, Copacabanas white sand runs for almost 5km in front of a lively nightlife district and residential suburb.
Known as the world's most famous beach, Copacabanas white sand runs for almost 5km in front of a lively nightlife district and residential suburb.
The non-stop beach parade of scantily dressed beautiful bodies and smiling faces embodies the heart and soul of Rio's 'Cariocas' culture that thrives on sun, beach, dance, drink and sport.
Crowded daily with friendly people, the wide beach often resembles more of a large sandy park than a beach, with full-size soccer pitches and volleyball courts situated between Avenida Atlantica and the sea.
With something always going on during the day and along the sidewalks at night, the beach has a non-stop party atmosphere: from people checking out the scene, playing volleyball and soccer, to drinking, eating and singing.
The beach is divided into numbered 'postos' (lifeguard stations). Those opposite the luxury hotels have their own security guards to protect guests from petty crime. It's best not to flaunt watches, jewellery or cameras.
The haunt of rich and poor alike, experienced locals typically come to the beach with only bathers, sunscreen and a wrap, which they can either sit or lie on, except for men who are suppose to sit on the hot sand.
• Watch Cariocas turn Cobacabana and Ipanema beaches into a huge sporting carnival with games of volleyball or footvollei (volleyball with no hands) and beach soccer that roll on throughout the day.
• On the beach you can buy almost anything you want, from a skimpy bikini, towels, kangas (sarongs), hats, shades and suntan lotion to peanuts, beer and cookies as well as sticks of grilled shrimp, shelled coconuts and even deep-muscle massages.
• Copacabana Beach is home to Rio's famous New Year's celebration – dress in white as the locals do, for good luck.
• One of the best shopping centres in Rio is just a short walk from the beach, as well as movie houses, theatres, fashion and jewellery shops, restaurants and nightclubs.
For that special romantic occasion try the luxurious Belmond Copacabana Palace facing Copacabana Beach. With a long-established reputation for exceptional service, the Palace is Rio's first choice for celebrities and royalty.
Copacabana offers a wide range of accommodation options to suit the majority of honeymoon budgets, including the following 5-star hotels…
Belmond Copacabana Palace
Location: Copacabana, Rio de Janeiro
Rating: 5-star
Ave nightly price: AUD558 per room
Description: The elegant 5-star Belmond Copacabana Palace offers luxurious rooms with marbled bathrooms and panoramic ocean views, located on Rio de Janeiro's Copacabana Beachfront. Services include a wellness spa and 3 gastronomic restaurants. The spacious rooms at the Belmond Copacabana Palace are individually decorated with English antique furniture and original artworks. All offer king-size beds, free use of internet and a free pair of Havaianas flip flops. Some include private balconies with panoramic city or ocean views. Guests can enjoy a daily breakfast served in Pérgula restaurant, which also offers Brazilian specialties and fresh seafood delicacies. Breakfast can also be served in-room and additional charges apply. Top Italian dishes are served in Cipriani restaurant and a selection of drinks are available at the Copacabana Piano Bar. The new MEE Restaurant offers Pan Asian cuisine, with a menu created by the chefs Kazuo Harada and Rafael Hidaka. A large selection of Japanese Sakes is also available.
Miramar Hotel by Windsor
Location: Copacabana, Rio de Janeiro
Rating: 5-star
Ave nightly price: AUD287 per room
Description: Located right across from the famous Copacabana Beach, the Miramar Hotel by Windsor features a green granite pool and a modern gym. This pet friendly, design hotel offers butler service and free WiFi. Guests can start the day admiring the beautiful beach view while savoring a rich breakfast. Decorated in grey tones, each room here comes equipped with air conditioning, a flat-screen cable TV, safe and minibar. The private bathroom includes toiletries and a bathrobe. Many shops, grocery stores, restaurants, bars and nightclubs are close to Miramar by Windsor. Beach service is available with towels, chairs and parasols. Guests can have a drink at the rooftop bar or enjoy the hotel's restaurant. Copacabana Fort is 700 metres from the Miramar Hotel whilst Lagoa Stadium is 3.8 km away. Santos Dumont Airport is at a distance of 11.7 km, while Galeão International Airport is 25 km away.
Windsor Atlântica
Location: Copacabana, Rio de Janeiro
Rating: 5-star
Ave nightly price: AUD267 per room
Description: The 5-star Windsor Atlântica is ideally located across from the blue waters of Copacabana Beach. It features an elegant spa and a rooftop pool, both with splendid sea views. Guests can enjoy local and international specialties at the award-winning Ristorante Alloro, as well as a 24-hour room service. Windsor Atlântica offers bright, sophisticated rooms with air conditioning, a TV and a minibar. They are elegantly styled with wooden furniture, contemporary décor and warm, natural tones. Most rooms feature scenic ocean views. A popular buffet breakfast is served every morning with fresh fruits and pastries. The spa at the hotel has a variety of treatments, and there is a second swimming pool for guests to use. They are also welcome to exercise or have a sauna session in the fitness centre. Charming shops, restaurants and lively bars are found just 2 blocks away from this hotel. The Beach Volleyball Arena is located 100 metres from Windsor Atlântica, whilst Copacabana Fort is 3.2 km away. Santos Dumont Airport is 9.6 km away, while Galeão International Airport is at a distance of 27.6 km.
Find the best deal, compare prices and read what other travellers have to say about these and more hotels in Copacabana and Rio de Janeiro at TripAdvisor.
Latest update Copacabana Beach honeymoon destination: 7 February, 2017


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Henan Jingxin machinery co., ltd is a professional machine manufacture, established in 1990, with 120 employees, including 12 technicians for research and development. Our company is located in the capital of Henan Province – Zhengzhou, which is the center of business and economy. Our main products as the followings:
Nut Processing Machinery: Peanut Sheller, walnut Sheller, cashew nut Sheller, peanut peeler, cashew nut peeler, peanut butter machine, almond Sheller and peeler, peanut roaster, cleaner, stoner.
Vegetable processing machine vegetable washing machine, vegetable cutter, onion peeler, galic peeler, onion slicer, onion strip packing machine
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1. Wood Working Machinery
2. Briquette Press Machine
3. Farm Machinery Hay Baling Machine
4. Fruit Processing Machine
5. Animal Feed Machines
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Tracing patterns: Critical approaches to on-screen fashion
In 1990, Jane Gaines and Charlotte Herzog's hugely influential edited collection, Fabrications, opened up the discussion of the complex relationship between the female consumer and the female viewer; and while an important body of work has developed within this area, the study of on-screen fashion continues to be somewhat marginalised in the academy. This article examines some of the recent contributions to the study of on-screen fashion, situating them in relation to broader debates about fashion, costume, feminism and identity. In so doing, it seeks to examine the fortitude field, 21 years on from Fabrications, in order to examine how the study of on-screen fashion has developed and how it may evolve in the future.
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Keywords: audience; costume; fashion; gender; multidimensional approaches; text
Document Type: Research Article
Affiliations: University of East Anglia
Publication date: 2011-01-01
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- Film, Fashion & Consumption is a peer-reviewed journal designed to provide an arena for the discussion of research, methods and practice within and between the fields of film, fashion, design, history, art history and heritage. The journal seeks to stimulate ongoing research on these topics and to attract contributions not only from scholars researching in these areas but also from practitioners, who are traditionally excluded from academic debate. The journal thus aims to unite and enlarge a community of researchers and practitioners in film, fashion, consumption and related fields, whilst also introducing a wider audience to new work, particularly to interdisciplinary research which looks at the intersections between film, fashion and consumption.
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129 Alder Springs Lane
Subdivision: The Farms
|Back to Property List
|Fabulous 4 BR quality built home in pristine condition with custom salt water pool on one of the most desirable streets in The Farms! Wonderful floor plan with formal dining, spacious living areas, enormous kitchen opens to inviting keeping room with stone fireplace. Two story master retreat on the main level. Three BR and Bonus on upper level, 3 car garage and large level fenced back yard. Don't miss the chance to enjoy wow outdoor living at home plus amenities of Homestead Recreation center!
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Listing courtesy of: J Cash Real Estate
The data relating to real estate on this Web site derive in part from the Carolina Multiple Listing Services, Inc. IDX program. Brokers make an effort to deliver accurate information, but buyers should independently verify any information on which they will rely in a transaction. All properties are subject to prior sale, change or withdrawal. Neither Sandy Reynolds, REALTOR nor any listing broker shall be responsible for any typographical errors, misinformation, or misprints, and they shall be held totally harmless from any damages arising from reliance upon this data. This data is provided exclusively for consumer -- personal, non-commercial use and may not be used for any purpose other than to identify prospective properties they may be interested in purchasing. © 2017 Carolina Multiple Listing Services, Inc.
Data updated October 23, 2017.


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descalificar (first-person singular present descalifico, first-person singular preterite descalifiqué, past participle descalificado)
- (transitive) to discredit
- (transitive, sports) to disqualify
- c becomes qu before e.
Conjugation of descalificar (See Appendix:Spanish verbs)edit data
1 Argentine and Uruguayan voseo prefers the tú form for the present subjunctive.Other verbs with this conjugation:
Selected combined forms of descalificaredit data
These forms are generated automatically and may not actually be used. Pronoun usage varies by region.
Derived terms[edit]
- Spanish words prefixed with des-
- Spanish lemmas
- Spanish verbs
- Spanish verbs ending in -ar
- Spanish transitive verbs
- es:Sports
- Spanish verbs ending in -ar (conjugation -car)
- Spanish irregular verbs in the subjunctive present
- Spanish irregular verbs in the imperative
- Spanish irregular verbs in the indicative preterite


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Accounting Terminology Essay
Accounting Terminology
Each of the following statements may (or may not) describe one of these technical terms. For each statement, indicate the accounting term described, or answer "None" if the statement does not correctly describe any of the terms.
a. The level of sales at which revenue exactly equals costs and expenses. Break-even point. b. Costs remain unchanged despite changes in sales volume. Fixed Costs. c. The span over which output is likely to vary and assumptions about cost behavior generally remain valid. Relevant Range. d. Sales revenue less variable costs and expenses. Contribution margin. e. Unit sales price minus variable cost per unit. Unit contribution margin. f. The reduction in unit cost achieved from a higher level of output. Economics of scale. g. Costs the respond to changes in sales volume by less than a proportionate amount. Semi variable costs. h. Operating income less variable costs. "None".
Exercise 20.7 – Using Cost-Volume-Profit Formulas
Exercise 21.2 – Home Depot's Financial Statements: Incremental, Sunk, and Opportunity Costs Read the footnote in Appendix A referring to Home Depot's decision to close all of its remaining big box stores in China. Write a short paragraph identifying the incremental, sunk and opportunity costs associated with this decision. Assume that any cost savings will be invested elsewhere in more productive stores.
Incremental costs relate to the difference in costs between alternative courses of action and incremental revenues. The incremental costs that would be that would occur from either remodeling or closing Home Depot an existing location would include cost of materials, overhead from the actual physical remodel, labor that includes employee pay for rearranging and moving merchandise during a remodel if it occurred, designing and planning costs. Opportunity costs are important factors when it comes to decision making because they define the costs of taking some action in terms of the value foregone or that's given up due to a particular action taken place. Opportunity costs of remolding would include profits on lost sales if the store is closed during remodeling, loss of current sales due to decrease in customer traffic (due to excessive noise, smell, dirt and inconveniences.
Stores could potentially lose profit if they are not able to stock the full line of products or keep items stocked during a remodel. Whereas a sunk cost is an outlay that has been irrevocably incurred at some time in the past; sunk costs cannot be changed no matter what course of action is taken and are irrelevant for purposes of decision making involving the future. Sunk costs related to either remodeling of the store that would need to be taken into consideration include original costs of the current store (decorations, paint, shelves, displays, carpet) and designs that will need to be replaced or removed during either remodeling or closing.
Exercise 21.6 – Incremental Analysis: Make or Buy Decision The cost to Swank Company of manufacturing 15,000 units of a particular part is $135,000, of which $60,000 is fixed and $75,000 is variable. The company can buy the part from an outside supplier for $6 per unit. Fixed costs will remain the same regardless of Swank's decision. Should the company buy the part or continue to manufacture it? Prepare a comparative schedule in the format illustrated in Exhibit 21-6.
It would be more beneficial for the company to manufacture the part rather than buy it from an outside provider.
Brief Exercise 22.9 – Flows of Costs through Manufacturing Accounts The President of Cold Moo Ice Cream Company, a chain of ice cream stores in the Midwest, was unhappy with the actual six-month profit figures for the company recently prepared by the CFO. The president asked the CFO for a profit breakdown, by store, of the actual six-month results. When the President received the report, he was extremely upset and called the CFO, into his office. The President stated, "These reports show that each store in the chain is profitable, but our company results are unprofitable! How can this be?" The CFO pointed out that each store was allowed to set prices for ice cream based on its cost structure. However, the stores' cost structures did not include headquarters costs of the costs of advertising and delivery of products.
What are the three characteristics for operating a successful responsibility accounting system? Consider whether the accounting system at Cold Moo Ice Cream Company includes the three characteristics of a successful responsibility accounting system. How could the responsibility accounting system at Cold Moo be improved?
As the Textbook states, "measuring performance along the lines of management responsibility is an important function. A responsibility accounting system holds individual managers accountable for the performance of the business centers under their control and provides top management with information useful in identifying strengths and weaknesses among units throughout the organization." The three characteristics of a successful operating accounting system will include budgets, will measure the performance, and contain timely performance reports. "Budgets serve as performance targets for each subunit in an organization. The accounting system will measure the performance of each responsibility center, and timely performance reports are prepared that compare the actual performance of each center with the amounts budgeted."
When reports are preformed frequently, it allows center managers to be able to keep their performances on target, and helps with the evaluation of the managers. It does not appear hat Cold Moo Ice Cream is following the timely reports method of the accounting system, which is essential to ensuring the financial information is accurate as possible, and to improve this aspect should be more intertwined with the actual budget and more accurately present how the performance of the store is measured.
To do so the responsibility income statement should also be presented, this contains not only the operating results of a particular part of a business but also the revenue and expenses of each profit center within that part, which could be extremely important to see how those centers within the same area measure and stack up against one another. For the responsibility income statement to be informative and useful it should essentially and efficiently be able to detail Variable Costs, Contribution Margin, Fixed Costs, Traceable Fixed Costs and Common Fixed Costs.
In addition, fixed costs that are common to both product lines amount to $125,000.00.
a. Prepare Chocolatiers' responsibility income statement for the current month. Report the responsibility margin for each product line and income from operations for the company as a whole. Also include columns showing all dollar amounts as percentages of sales.
b. According to the analysis performed in part a, which product line is more profitable? Should the common fixed costs be considered when determining the profitability of individual product lines? Why or why not? According the analysis in part a, the solid product line is more profitable. When determining profitability of any product line, common fixed costs should not be considered. Only the costs that are directly traceable to the product lines should be included. Common fixed costs are not directly traceable to any product, as they are arbitrarily allocated in proportion to a chosen factor, for example, machine hour or square feet of a certain space occupied.
c. Chocolatiers has $15,000.00 to be used in advertising for one of the two product lines and expects that the expenditure will result in additional sales of $50,000.00. How should the company decide which product line to advertise?
The effects of this campaign will typically be in both sales and variable costs, and therefore the company should select the product line based on which product will have the highest contribution margin ratio, which is the percentage of sales, service revenues or selling price that remains after all variable costs and variable expenses have been covered. This method takes into consideration the limited time frame of the advertising campaign, where fixed costs will most likely not be affected.
Subject: Cost,
University/College: University of Chicago
Type of paper: Thesis/Dissertation Chapter
Date: 27 September 2016
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Couturier Merges PDF Files on GNOME Desktop
The Couturier Mono program merges multiple PDFs into a single file. It follows the old UNIX policy: one program for one task.
Couturier merges PDFs and numerous image formats into a single PDF document, with optional password protection. Since its first release in April, developer Charalampos Emmanouilidis made some changes to the UI and added an About Courier menu. A .desktop file integrates version 0.4 into the GNOME menu with its own Couturier logo.
Couturier speaks English, German, Italian, French and Greek. Download is available for source code and a package for Ubuntu 9.04 from gtk-apps.org.
Issue 30: Getting Started with Linux/Special Editions
Buy this issue as a PDF
Linux Comes to Windows
Run multiple Linux distributions in Windows 10.
Docker Embraces Kubernetes
Docker is now offering Kubernetes as an orchestration platform.
Kubernetes 1.8 Announced
The new release comes with two new features for better security.
Final Ubuntu Desktop 17.10 Beta Arrives
Ubuntu completes the cycle of life and goes back to letter A and Gnome.
Linus Torvalds Invites Attackers to Join the Kernel Community
He wants attackers to join the community instead of attacking the code.
Oracle Donating Java EE to the Eclipse Foundation
Oracle is recommending a new name for the Java Enterprise Edition platform.
Reddit Closing Doors to Open Source
The peanut gallery of the Internet is closing its open source repository.
Largest Open Source Summit to Date Around the Corner
LinuxCon is now Open Source Summit.
Gnome is Celebrating it's 20th Birthday
More than 33 releases since the first release of Gnome.
SQL Server Comes to RHEL; OpenShift Comes to Azure
Microsoft and Red Hat expand their partnership.


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Ritter & Ritter, Inc. Pension & Profit Plan v. The Churchill Condominium Assn.
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The RCMS UNITE Club was active last week. The group collected about 900 rolls of toilet paper to donate to local drug rehab facilities. They also blew up 100 balloons in preparation for the Unite Bowl game on Friday evening and several members participated in the balloon launch at halftime.
Oct 17 2017
RCMS UNITE Club "Wipes Out Drugs"
Permanent link to this article: http://rockcastle.kyschools.us/blog/rcms-unite-club-wipes-out-drugs/
Oct 16 2017
Local Planning Committee Public Forum No. 1
The Rockcastle County Local Planning Committee will conduct a PUBLIC FORUM on Monday, October 23, 2017 at the Rockcastle County Teaching and Learning Center at 5:30 p.m. and hold a Regular Local Planning Committee Meeting thereafter. The Local Planning Committee will convene a Public Forum to solicit public comment on the proposed District Facilities Plan. …
Permanent link to this article: http://rockcastle.kyschools.us/blog/local-planning-committee-public-forum-no-1/
Oct 13 2017
RCMS Bravo Students Build Rube Goldberg Machines
Students in 6th, 7th, and 8th grade Math and Science Bravo designed and built Rube Goldberg machines. The machine requirements were: must contain at least 3 simple machines and 2 energy transfers, must contain at least 5 separate steps, and must complete an end task. 6th Grade Rube Goldberg Machines 7th Grade Rube Goldberg Machines 8th Grade …
Permanent link to this article: http://rockcastle.kyschools.us/blog/rcms-bravo-students-build-rube-goldberg-machines/
Oct 13 2017
Roundstone Elementary Participates in UNITE Wipe-Out Drugs Challenge
As part of this year's annual UNITE Bowl football game, Rockcastle County and Clay County Schools are collecting toilet paper to be donated to men's and women's drug treatment centers. Roundstone Elementary did an awesome job in this service project by bringing in 1, 581 rolls! All collected packages will be on display at the …
Permanent link to this article: http://rockcastle.kyschools.us/blog/roundstone-elementary-participates-in-unite-wipe-out-drugs-challenge/
Oct 13 2017
KSP Visits Criminal Justice Classes at RCHS
RCHS Students in Mrs. Coleman's Introduction to Criminal Justice classes recently had guest instructors during their study of "Police and the Constitution". KSP Troopers Adam Hensley and Scotty Pennington as well as Detective Ryan Loudermilk came to RCHS and discussed general topics such as the path to becoming a KSP Trooper and gave specific instruction …
Permanent link to this article: http://rockcastle.kyschools.us/blog/ksp-visits-criminal-justice-classes-at-rchs/
Oct 13 2017
Mrs. Sheena's Preschoolers Visit Sigmon Farm
Permanent link to this article: http://rockcastle.kyschools.us/blog/mrs-sheenas-preschoolers-visit-sigmon-farm/
Oct 12 2017
ATC Students Complete OSHA 10 Program
Rockcastle County ATC Seniors in the electrical technology program are the first students to complete the OSHA 10 program in this county. This privilege has been made available with the collaboration of the KDE, Rockcastle ATC and Eastern Kentucky University. This is a great opportunity for students to understand on the job safety and earn …
Permanent link to this article: http://rockcastle.kyschools.us/blog/atc-students-complete-osha-10-program/
Oct 11 2017
FBLA Sigmon Farm Community Service Event
Rockcastle County Area Technology Center's Future Business Leaders Of America (FBLA) members will be donating community service time to Sigmon's Farm. There will be all kinds of fun and activities for the kids. This will allow members to be out and helping the community. We will also be hosting (weather permitting) a Fall Family Photo …
Permanent link to this article: http://rockcastle.kyschools.us/blog/fbla-sigmon-farm-community-service-event/
Oct 11 2017
RCHS JROTC Competes in Raider & Drill Competition
Twenty-three Rockcastle County High School JROTC Cadets traveled to Whitley County High School on October 7, 2017 to compete in their Raider and Drill Competition. The team was highly motivated performing their best on each event. The competition consisted of eight events: obstacle course, pioneer gauntlet, rope bridge, academic test, color guard, mile run, archery, …
Permanent link to this article: http://rockcastle.kyschools.us/blog/rchs-jrotc-competes-in-raider-drill-competition/
Oct 11 2017
MVES Preschool Students Visit Sigmon Farm
MVES Preschool students enjoyed visiting Sigmon Farm pumpkin patch on Thursday, Oct. 5th. Here are some pictures showing the students picking their "perfect" pumpkin, some families who went with our class, feeding the animals. The children always love this annual trip to the farm to learn about how pumpkins grow, life on the farm, and caring …
Permanent link to this article: http://rockcastle.kyschools.us/blog/mves-preschool-visits-sigmon-farm/


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Campaign To Create "Gender-Free" ChildrenJanuary 5, 2012 No Comments
By pass the commentary and go straight to the factual video – whether or not you're for this – 15 years ago it was said this would occur and now it is.
Gender free schools: http://americanvisionnews.com/946/gender-free-children-coming-to-a-public-school-near-you
Don't forget CA has gender neutral bathrooms as well.
Gender free bathrooms: http://www.bazeley.net/mosaic/news/archives/news/demand_growing_for_genderneutral_restrooms_at_workplaces_and_campuses.html
GLBT support of gender free bathrooms http://www.chancesdances.org/gender-neutral-bathrooms
Gender-free children: coming to a public school near you
by Joel McDurmon on Dec 31, 2011
From Chalcedon.edu:
Coming soon, to a public school near you: the teaching that "gender is a spectrum," and "gender identity" a state of mind, a social construct-and it's all part of a top-down campaign to convince your children that they can be "whoever they want to be." Boys can be girls and girls can be boys.
In March, 2010, the National Education Association, America's biggest and most powerful teachers' union, sent a delegate to the United Nations Commission on the Status of Women to testify to the need for all the world's national governments to embark on a program of radical sex education in their public schools. To quote from a contemporary news report:
Comprehensive sex education is "the only way to combat heterosexism and gender conformity," [NEA delegate Diane] Schneider proclaimed, "and we must make these issues a part of every middle and high-school student's agenda." "Gender identity expression and sexual orientation are a spectrum," she explained, and said that those opposed to homosexuality "are stuck in a binary box that religion and family create."
In April the Council of Europe announced that it would soon "finalize a new convention that defines 'gender' as a social construct rather than as a distinctive grounded in biology."
Yes, it's coming right down from the top.
It's by no means limited to Canada and Europe:
the campaign to create "gender-free" children has already begun in the United States. The Redwood Heights Elementary School in Oakland, California, has already installed a "gender coach" in the classroom to teach very young children that "you can be a boy or a girl, or both." Don't take our word for it:Tags: gender conformity, gender free bathrooms, Gender Free Children, GLBT, heterosexism, Redwood Heights Elementary School Oakland CA, sex educationEducation