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Easy to use music application suitable for young children, play with three different instruments to make your own Happy Music.
Version 1.0 contains:
- 8 Guitar chords
- 8 Piano keys
- 8 Strings notes
- No popup advertising
- No in game purchases needed
- No registration needed
- No internet connection needed
Recommended for toddlers and kids two years and up.
If you like this app or have any comments or suggestions please review it and leave us a note.
Hope you enjoy it :)


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Coaching Conference – 8th March 2018
The University of South Wales has had a proud association with the coaching profession for several years. Through our Coaching Centre we routinely deliver ILM Coaching qualifications, CPD evenings and host the South Wales Co-Coaching Group for the Association for coaching. Targeted at all coaching practitioners looking to develop themselves personally and professionally, the Coaching Conference will provide you with a range of new, practical tools to take away and immediately aid your work with your clients, as well as considering a broad range of approaches of 'challenging limitations' in coaching practice.
Intended Audience:
- Coaches and mentoring practitioners
- Trainers
- Training and HR managers
- Anyone that would find Coaching of use to them in their role.
Our 5th Annual coaching conference will take place in Cardiff in March 2018, bringing together leading practitioners and academics in the field of Coaching, exploring tools and ways to improve coaching techniques.
To register your interest, email [email protected]

subset: commoncrawl


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3/17 Online Sale-a-bration Party!
Only five more days to Sale-a-brate and your last chance to place orders for FREE Sale-a-bration products! For every $50 that you order, you can select something FREE from our Sale-a-bration brochure HERE. If your shopping list is over $150, you will get hostess benefits, too! Shop 24/7 right from your computer HERE. Click the shop now button on the left and you are on your way! To thank you, watch for this cute card to come your way!
If your wish list isn't quite to that level (or rather your pocket book!), you are welcome to place your order through my Online Sale-a-bration Party that will end at NOON Central Time on March 21. For every $25 ordered, I will put your name into a drawing and one lucky person will get hostess benefits. But EVERYONE will get this CUTE Sale-a-bration card pictured above! This card features three awesome Sale-a-bration products: Sycamore Street Designer Series Paper, the awesome Vine Street embossing folder and the stamp set called Patterned Occasions.
How can you participate? Just email me and I will give you a hostess code that you can use when you place your online order. If you local and want the order shipped to me or if you are uncomfortable placing orders online, let me know and I can place it for you. Again, you will get an entry for every $25 that you spend and your order will be shipped right to your door!
Have a great day and thanks so much for stopping by Stamping to Share!! I truly appreciate you and hope that you will enjoy this Online Sale-a-bration Party!
24/7 Shopping at my Stamping to Share Website
Earn hostess credit with orders of $150 or more!
24/7 Shopping at my Stamping to Share Website
Your loyalty earns free stamp sets!


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Automatische Dokumentation Matlab-Quellcodes Automatic Documentation Matlab source codes
0 Downloads
Updated 25 May 2011
Description: This is a small example of how to use the toolbox to generate m2html documentation on projects written in Matlab.
To do the following procedure:
1. Download the m2html Toolbox from:
2. Download the Graphviz from:
3. Unpack m2html toolbox and add to setpath in Matlab
4. Install Graphviz
5. Copy the example in the m2html toolbox, and run this line:
5. The documentation will created on a internal folder called docu.
Viel glueck....
Just to complete my question below : In fact I cannot generate the dependency graph. Which is empty with the demo.m example. Here the only error message I am getting during the execution
In template/set (line 104)
In m2html (line 881)
Creating dependency graph proyecto\docu2\proyecto\graph.dot...Warning: NARGCHK will be removed in a future release. Use NARGINCHK or NARGOUTCHK instead.
> In mdot (line 21)
In m2html (line 921)
'"dot"' is not recognized as an internal or external command,
operable program or batch file.
Hello, I am really interest into this but cannot get it to work. Can someone share an example on how to generate flow chart from .m files
Download apps, toolboxes, and other File Exchange content using Add-On Explorer in MATLAB.


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Georges Brassens was a French singer-songwriter and poet. He wrote and sang, with his guitar, more than a hundred of his poems, as well as texts from many others such as Victor Hugo, Paul Verlaine, or Louis Aragon. In 1967, he received the Grand Prix de Poésie of the Académie française. Between 1952 and 1976, he recorded fourteen albums that include several popular French songs such as Les copains d'abord, Chanson pour l'Auvergnat, La mauvaise réputation, and Mourir pour des idées. Most of his texts are black humour-tinged and often anarchist-minded.
With the Skylark "experiment" behind him, Paul Desmond reverted back to the relaxed quartet format that suited him well in the past. The reason? Through Jim Hall, he found a little-known, splendid guitarist in Toronto named Ed Bickert who became his new gigmate in 1974, and this album was meant to show his discovery off. In fact, it sparked a Desmond renaissance where he regained a good deal of the witty spark and erudite cool of his collaborations with Hall, no matter how unfashionable it was to play this way in 1974.
British Chess Magazine is the world's oldest chess journal, published continuously since 1881. It appears monthly and is packed with in depth informative content about the Royal Game. You will find high quality games and analysis, reports on recent tournaments, articles and analysis about openings, interviews with famous players, authoritative and independent book and DVD reviews.


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Monteray Pines in Corolla is located within easy walking distance of shops, restaurants, movies, grocery stores and more. The 48 units in four buildings are an affordable way to own in Corolla for a primary residence, vacation condominium, second home or employment rental.
Homeowner Association Documents
- MPN Articles of Incorporation
- MPN Declaration, Bylaws and Articles
- MPN Resolution 12-5-14 ref Common Elements, Units, Insurance


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I just bought the sims 1 game from online. All discs and everything. I have windows 7 and when I downloaded the game it worked fine except there is no sound effects! The only sound that works is the music. The sims don't make any sound when talking and there is no sound when clicking etc. Does anyone know what this could be? I'm thinking it might be because I need a program called directx 7, but I can't download it on this version of windows. I only have directx 11, but I'm not sure if that's the problem.
No sound on recently downloaded sims 1 game!
Started by Simmer4689 , Jul 22 2017 01:59 PM
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Wonderful place! Just a really relaxed feeling, excellent service and a great manager who takes time to personally make sure your stay lives up to the expectations. Good local food in the restaurant and very attentive staff that made sure you you got the same things for breakfast every day (if you had a special request one morning, the staff made sure you got the same the next day even if it wasn´t the same staff crew on duty)
- Official Description (provided by the hotel):
- Just 10 minutes from the center of Marrakech, The Hotel by Beldi sits in the magnificent 14 hectares of the Beldi Country Club. Here you will find a charming blend of Moroccan tradition and French chic. A green oasis of charm, ancient olive trees, stylish swimming pools and restaurants with views across the rose gardens to the Atlas Mountains. The 28 suites, exquisitely and individually furnished in the Beldi style, have been built to resemble a Moroccan village, with its narrow alleyway's, shady court yards and riads. The hotel has a swimming pool reserved for residents only, surrounded by olive trees and gardens. There is a garden restaurant and an indoor winter restaurant with a fireplace. There is one tennis courts and a delightful small 'home cinema'. During the winter, the swimming pool in the orangeraie of the Beldi is heated. ... more less


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High Precision Water Jet Cutting Machine Part Direct Drive Pump
|FOB Price:
|US $10,000-15,000 / Piece
|Min. Order:
|1 Piece
|Min. Order
|FOB Price
|1 Piece
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|Production Capacity:
|20 Pieces Per Year
|Transport Package:
|Wooden Packing Outside
|Payment Terms:
Request a custom order and have something just for you!Send Customized Request
- Model NO.: DDP-30
- Weight: 1025kg
- Warranty: One Year
- Application: Water Jet Cutting Machine
- Max.Pressure: 60000psi
- Material: Stainless Steel
- Specification: 1473mm *1205mm*1056mm
- Type: H20 Jet 50 Pump
- Certificate: Ce
- MOQ: One PC for Waterjet Pump
- Rated Power: 37kw(50Hz)
- Place of Origin: Shanghai, China
- Trademark: YH
- Origin: Shanghai
Water jet cutting, ultra-high pressure water jet cutting machine is to ordinary water through an ultra-high pressure presses, the water pressure to 3000bar, and then through the channel diameter of 0.3mm water nozzle produces a water jet about 3 times the speed of sound, Under the control of the computer can be easily cut any graphics soft materials, such as paper, sponge, fiber, etc., if added to increase the cutting power of sand, you can cut almost any material.
Water jet cutting machine consists of four parts,water jet cutting table( cnc controller),water jet cutting head,water jet abrasive feeder system and waterjet intensifier pump.
Cutting material :water jet cutting machine can cut rubber, foam, plastic, composite, stone, tile, metal, marble, glass and so on.
Product detail
|Direct drive pump specification
|rated power
|output pressure
|operating voltage and power
|210-240/360-420v 50hz
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Our Advantage
Packing and Shipping
Water jet cutting machine spare part package : soft packing inside ,carton packing outside.
water jet cutting machine package : wooden package
The package ways is also can according to the requirement of customer


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Finally my Danish Mermaid kit has arrived - sooooo beautiful!, and with it some more additional balls of Stone washed to practise.
Started a larger swatch yesterday, much larger than the pattern suggests, with a 4.5 mm hook and the additional yarn - I want to feel the drape of the crocheted fabric, and there is always a good use for larger swatches :)! You can see more photos of Curly Sue's Hygge Swatch Dress here.
The gauge fits perfectly, but the fabric feels quite stiff even before x-stitching it. I just finished my "swatch" tonight and I'll start another one tomorrow, with a 5 mm or even a 5.5 mm hook. I know that I'll run our of yarn (again!), but I hope I'll find a few extra balls of Stone washed to finish a drapey stole.
Decided on a 5 mm hook - the 5.5 mm swatch (the solid herart) is even more drapey, but the x-stitches get kind of lost on it. The 5mm hook makes a nice and soft fabric that isn't stiff, and the cross-stitches look nice.
Never before I had cross-stitches on crocheted fabric, and my last cross-stitching is about 15 years ago … I suppose it's like riding a bike, a few meters, and you are back :).
Week 1: What an adventure! In spite of "bobbelitis" in the Facebook group I made my bobbles just as the designer advises, they come out nice and neat and don't crush the design. Love the decent way the colors change!
Week 2: Finished just a few minutes ago, such FUN!!!!! Struggled quite a time with the surface crochet - going diagonally and counting to 5 at the same time can be quite hard :)! Trial and error - my way of learning, never did surface crochet before. Cross-stitching was a real delight - I had nearly forgotten how soothing cross-stitching can be! I love color H of the Danish Mermaid kit best - so I changed the colors for the cross-stitched flowers (F to H, G to I, H to F and J) - this also helps to show the lovely design better. And I have a reserve ball of H, so I can use this color extensively :).
I hope next Wednesday and week 3 will come soon!
Week 3 - First kit finished, second kit will get finished tonight. Played a bit with colors on the heart cross-stitch section. Still very very happy with this project!


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Lovenberg, Erlander, Baron, Racke, Slone, Siegel, Craft, Burns, Danielson, Sutcliffe: Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. in Proceedings of the National Academy of Sciences of the United States of America 1993
5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis.
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
5-hydroxytryptamine receptor 1F
, serotonin receptor 1F
, 5-HT1F receptor
, 5-hydroxytryptamine (serotonin) receptor 1F
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, serotonin receptor gene (similar to Mm Htr1eb)
, 5-hydroxytryptamine 1E receptor
, 5-HT-1E-beta
, 5-hydroxytryptamine (serotonin) receptor 1E beta
, 5-hydroxytryptamine receptor 1F-like


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New Delhi, Feb 29 (ANI): Union Home Minister P. Chidambaram on Wednesday said that the proposed National Counter Terrorism Centre (NCTC) should have the bare minimum powers, including the power to arrest, recommended by the committees to have certain operational capability while conducting a counter- terrorism operation.
" When you know that a terrorist crime has been committed or there is a design to commit a terrorist crime, at that stage if the NCTC must have a certain operational capability the bare minimum power is the power to arrest," he added.
"The NCTC must have a certain operational capability as recommended by the committees, which have looked into it. You need to have an operational capability while conducting a counter-terrorism operation; the section is attracted only when a counter-terrorism operation is going on," said Chidambaram, when asked about why the powers to arrest is important in case of NCTC.
When asked whether the NCTC's power of right to arrest will open to judicial scrutiny, Chidambaram said: "Only the operations of the NCTC will be given the power under 43(A). And immediately after arrest, the persons has to be handed over to the nearest police station then the case will be registered in the nearest police station, You don't anticipate any legal difficulty. This has been examined carefully by the Intelligence Bureau."
Chidambaram further said: "And the next section says as soon as you arrest without unnecessary delay the person arrested must be handed over to the nearest police station. The next section says the Station House Officer of the police station will then take up the case under the Criminal Procedure Code. This is a bare minimum power if you agree the NCTC must have a certain operational capability while conducting a counter terrorism operation."
The Ministry of Home Affairs (MHA) has written to the state chief secretaries inviting them and Home Commissioners of all states along with the DGPs and heads of anti-terror organisations for a meeting on March 9 to have elaborate discussions on the states' concerns over the NCTC. The meeting will be chaired by the Union Home Secretary.
Chidambaram had earlier written to 10 chief ministers, saying countering terrorism is a shared responsibility, and the Centre will continue to work with states to fight the menace.
Several state governments, including the Trinamool Congress (TMC), which is the second largest in the Congress-led United Progressive Alliance Government (19 Members of Parliament), joined the chorus against what is being seen as an attempt to infringe upon state's rights.
The main task of the NCTC would be to ensure that the wide variety of security organizations in the country work in tandem, at least on issues related to terrorism.
It will also have the power to seek information, including documents, reports, transcripts, and cyber information from any agency, including from the Central Bureau of Investigation (CBI), National Investigation Agency, National Technical Research Organization, Directorate of Revenue Intelligence and all seven central armed police forces including the National Security Guard (NSG).
The body, which will function under the Intelligence Bureau, has been given its own operational wing with powers to arrest and conduct searches under Section 43A of the Unlawful Activities Prevention Act. (ANI)
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FNBO, which has made itself pretty well known among online bankers, is launching an online video contest: the Pay Yourself First Challenge.
FNBO Direct wants to hear about your savings obstacles. Have you been struggling to save for college tuition or a wedding, pay off medical bills, go on the vacation of a lifetime or just get out of debt? Whatever the reason, we want to hear about it. Make us laugh. Make us cry. Make us say, "Wow! This person really needs to learn how to Pay Yourself First!"
To enter the contest, you have to shoot a 10- to 60-second video on your savings challenges and upload it to FNBO's YouTube channel.
The winner, as judged by FNBO, receives a "Restore Your Balance" vacation — a trip to a resort and spa (or cash in place of the voucher).
What are the judges looking for?
According to the official rules …
* Saved the most money during the challenge – based on percentage increase, rather than dollar amount saved (50%)
* Ranking by financial experts based on challenger's saving skill level: tactics for saving, ability to meet saving goal, and sharing saving challenges and solutions with PYF community (20%)
* Vote by American public via poll on www.PYFChallenge.com that judges the challengers' saving skill level: tactics for saving, ability to meet saving goal, and sharing saving challenges and solutions with PYF community (20%)
* Adherence to contest requirements, including active participation in the challenge activities such as blogging on www.PYFChallenge.com, and other promotional activities (10%)
Check out FNBO's promotional video for the contest.


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Kid Safe Workshop | Martial Arts | White Marsh - Middle River | Baltimore | Maryland
About Tiger Paw Middle River Karate
Kids Karate
Adults Martial Arts
NEW! Ultimate Fitness Tae Boxing Aerobics
Driving Directions to
Tiger Paw Martial Arts
in Middle River, MD
School News / Blog
Is it IMPORTANT to YOU that Children STAY SAFE?
Did you know that each year there are about 3,000 to 5,000 non-family abductions reported to police? Those are just the ones that are reported. How scary is that?
Our children are our most precious asset, aren't they?
Parents, guardians, and adults who care for children face constant challenges when trying to help keep children safer in today's fast-paced world. For decades, children were taught to stay away from "strangers." But this concept is difficult for children to grasp and often the perpetrator is someone the child knows. It is far more beneficial to help build a child's confidence and teach them exactly how to respond properly to any potentially dangerous situations, than teaching them to look out for a particular type of person.
Is your child abduction safe? We're PROUD to be KID SAFE EXPERTS.
As a FREE special community service, our SPECIALLY TRAINED, EXPERT INSTRUCTORS will teach your family how to avoid and escape these potentially family changing experiences.
Take a moment and call us IMMEDIATELY at 410-248-0606 to enroll in our next KID SAFE workshop - it might just be the smartest decision you ever make for your family. See you there!
Tiger Paw Martial Arts & Karate
117/117A Beacon Road Middle River, Maryland 21220 /
Copyright © 2010-2014. All rights reserved /
Martial Arts Websites by ESWDG


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"I don't care who anybody sleeps with. If a couple has been together all that time – and there are gay relationships that are more solid than some heterosexual ones – I think it's fine if they want to get married. I don't know how people can get so anti-something. Mind your own business, take care of your affairs, and don't worry about other people so much."
Betty White
Categories: Betty White Bisexual Celebrities Gay Golden Girls Lesbian LGBT News Opinion Role Models Transgender


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Research Topics
Genomes and Genes
L selectin
Gene Symbol: L selectin
Description: selectin, lymphocyte
Alias: AI528707, CD62L, L-selectin, LECAM-1, Lnhr, Ly-22, Ly-m22, Lyam-1, Lyam1, L-selectin, CD62 antigen-like family member L, LAM-1, LECAM1, leukocyte adhesion molecule 1, leukocyte-endothelial cell adhesion molecule 1, lymph node homing receptor, lymphocyte antigen 22, lymphocyte surface MEL-14 antigen
Species: mouse
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications118 found, 100 shown here
- The selectins: vascular adhesion moleculesT F Tedder
Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
FASEB J 9:866-73. 1995..Future studies are focused on how the selectins interact with the increasing array of other adhesion molecules and inflammatory mediators...
- L-selectin from human, but not from mouse neutrophils binds directly to E-selectinO Zöllner
Institute of Cell Biology, ZMBE, University of Munster, Germany
J Cell Biol 136:707-16. 1997..The clear difference between human and mouse L-selectin suggests that E-selectin-binding carbohydrate moieties are attached to different protein scaffolds in different species...
- Ligation of L-selectin through conserved regions within the lectin domain activates signal transduction pathways and integrin function in human, mouse, and rat leukocytesD A Steeber
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 159:952-63. 1997..Signaling through L-selectin may enhance leukocyte-endothelial cell interactions by serving as an activation/priming step during rolling, thereby promoting subsequent firm cell-cell adhesion in the presence of inflammatory mediators...
- L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific toleranceYalai Bai
Carl C Icahn Institute for Gene Therapy and Molecular Medicine and Recanati Miller Transplant Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
J Immunol 168:1579-89. 2002..Concurrent administration of anti-L-selectin (CD62L) Ab, which prevents lymph node homing, prevents indefinite allograft survival and tolerance...
- Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathwaysBaohui Xu
Dept of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
J Exp Med 197:1255-67. 2003..This high level of involvement of alpha4beta1 integrin/VCAM-1 is unique among secondary lymphoid tissues, and may help unify lymphocyte migration pathways and immune responses in BALT and other bronchopulmonary tissues...
- Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte traffickingLinda V Sinclair
Department of Cell Biology and Immunology, University of Dundee, Dundee DD1 5EH, UK
Nat Immunol 9:513-21. 2008..The key lymph node-homing receptors CD62L (L-selectin) and CCR7 were highly expressed on naive T lymphocytes but were downregulated after immune activation...
- L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivityYuka Shimada
Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
J Immunol 170:4325-34. 2003....
- Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcriptionAilin Bai
Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 40 Ames Street, Cambridge, MA 02139, USA
J Immunol 178:7632-9. 2007..In this study, we show that in reporter gene assays KLF2 directly activates the promoters of both CD62L and sphingosine-1-phosphate receptor 1 (S1P1), whose expression is critical for T cell egress from the thymus and ..
- Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34P R Baum
Department of Gene Expression, Immunex R and D Corporation, Seattle, WA 98101
EMBO J 13:3992-4001. 1994..In addition, the HTLV-1 regulation of gp34 suggests a possible connection between virally induced pathogenesis and the OX40 system...
- Differential expression of ICAM-1 and LFA-1 versus L-selectin and VCAM-1 in autoimmune insulitis of NOD mice and association with both Th1- and Th2-type infiltratesS Martin
Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
J Autoimmun 9:637-43. 1996..ICAM-1 and LFA-1 expression is seen prior to L-selectin and VCAM-1. However, adhesion molecule expression during Th1 versus Th2 cell infiltration is very similar, suggesting similar adhesion molecule requirements of the two Th subsets...
- Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathwaysD A Steeber
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 163:2176-86. 1999..Thus, members of the selectin and Ig families function synergistically to mediate optimal leukocyte rolling and entry into tissues, which is essential for the generation of effective inflammatory responses in vivo...
- Selectin-independent leukocyte rolling and adhesion in mice deficient in E-, P-, and L-selectin and ICAM-1S B Forlow
Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Am J Physiol Heart Circ Physiol 280:H634-41. 2001..Comparison of our data with mice lacking individual or other combinations of adhesion molecules reveal that elimination of more adhesion molecules further reduces leukocyte recruitment but the effect is less than additive...
- ICAM-1-dependent pathways regulate colonic eosinophilic inflammationElizabeth Forbes
Allergy and Inflammation Research Group, Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Leukoc Biol 80:330-41. 2006..These studies demonstrate that beta2 -integrin/ICAM-1-dependent pathways are integral to eosinophil recruitment into the colon during GI inflammation associated with colonic injury...
- The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphaticsLevi G Ledgerwood
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Nat Immunol 9:42-53. 2008..Thus, the increased sphingosine 1-phosphate present in inflamed peripheral tissues may induce T cell retention and suppress T cell egress...
- Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient miceM L Arbones
Cell Genesys, Incorporated, Foster City, California 94404
Immunity 1:247-60. 1994..Thus, L-selectin plays an essential role in leukocyte homing to lymphoid tissues and sites of inflammation...
- L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sitesT F Tedder
Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Exp Med 181:2259-64. 1995..These results demonstrate that L-selectin plays a prominent role in leukocyte homing to nonlymphoid tissues during inflammation and that blocking this process can be beneficial during pathological inflammatory responses...
- Impaired primary T cell responses in L-selectin-deficient miceJ Xu
Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Exp Med 183:589-98. 1996..L-selectin does not appear to be rate limiting for the events leading to antigen-driven neutrophil recruitment, since normal DTH responses are obtained at late time points after immunization...
- Lyphocyte migration in L-selectin-deficient mice. Altered subset migration and aging of the immune systemD A Steeber
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 157:1096-106. 1996..Therefore, L-selectin-dependent pathways of lymphocyte migration are important for the normal migration of both naive and memory lymphocytes...
- Humoral immune responses in L-selectin-deficient miceD A Steeber
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 157:4899-907. 1996....
- The route of antigen entry determines the requirement for L-selectin during immune responsesM D Catalina
Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235 9072, USA
J Exp Med 184:2341-51. 1996....
- Intrinsic differences in L-selectin expression levels affect T and B lymphocyte subset-specific recirculation pathwaysM L Tang
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 160:5113-21. 1998..Thus, the differential migration of T and B lymphocyte subsets to lymphoid tissues is regulated in part by subset-specific differences in L-selectin expression levels...
- The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patchesE J Kunkel
Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA
J Immunol 161:2449-56. 1998..In situ, beta 7 integrins and L-selectin account for all lymphocyte homing to Peyer's patches, but P-selectin-dependent rolling, as induced by minimal trauma, may support trafficking of effector T lymphocytes to Peyer's patches...
- Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectinU Jung
Department of Biomedical Engineering, University of Virginia Health Sciences Center, Charlottesville 22908, USA
J Immunol 162:6755-62. 1999..We conclude that any one of the selectins can support some neutrophil recruitment but eliminating all three selectins significantly impairs neutrophil recruitment...
- L-selectin facilitates emigration and extravascular locomotion of leukocytes during acute inflammatory responses in vivoM J Hickey
Immunology Research Group, University of Calgary, Calgary, Alberta, Canada
J Immunol 165:7164-70. 2000..These findings indicate that L-selectin is important in enabling leukocytes to respond effectively to chemotactic stimuli in inflamed tissues...
- L-selectin shedding regulates leukocyte recruitmentA Hafezi-Moghadam
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
J Exp Med 193:863-72. 2001..These observations help to resolve the apparent discrepancy between the minor contribution of L-selectin to rolling and the significant leukocyte recruitment defect in L-selectin knockout mice...
- Importance of primary capture and L-selectin-dependent secondary capture in leukocyte accumulation in inflammation and atherosclerosis in vivoE E Eriksson
Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
J Exp Med 194:205-18. 2001..What is more, secondary capture occurs on atherosclerotic lesions, a fact that provides the first evidence for roles of L-selectin in leukocyte accumulation in atherogenesis...
- CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cellsH Nakano
Department of Medicine and Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
J Exp Med 194:1171-8. 2001..These cells also display a strain-specific variation in frequency, being fivefold increased in the LNs of BALB/c relative to C57BL/6 mice. These CD11c(+)CD11b(-)B220(+)Gr-1(+) cells appear to be the murine equivalent of human pDCs...
- P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skinTakako Hirata
Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Immunol 169:4307-13. 2002..P- and E-selectin-independent migration of Tc1 cells into the inflamed skin was predominantly mediated by L-selectin. These observations indicate that all three selectins can mediate Tc1 cell migration into the inflamed skin...
- P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venulesMarkus Sperandio
University of Virginia Health System, Cardiovascular Research Center, MR5 Bldg, Rm 1013, P O Box 801 394, Charlottesville, VA 22908 1394, USA
J Exp Med 197:1355-63. 2003..L-selectin binding to PSGL-1 initiates tethering events that enable L-selectin-independent leukocyte-endothelial interactions. These findings provide a molecular mechanism for the inflammatory defects seen in L-selectin-deficient mice...
- Leukocyte migration is regulated by L-selectin endoproteolytic releaseGuglielmo M Venturi
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
Immunity 19:713-24. 2003..Thus, endoproteolytic cleavage regulates both homeostatic and activation-induced changes in cell surface L-selectin density, which directs the migration patterns of activated lymphocytes and neutrophils in vivo...
- L- and P-selectins collaborate to support leukocyte rolling in vivo when high-affinity P-selectin-P-selectin glycoprotein ligand-1 interaction is inhibitedVictoria C Ridger
Cardiovascular Research Unit, University of Sheffield, Sheffield, UK
Am J Pathol 166:945-52. 2005..Together these data suggest that leukocytes can continue to roll in the absence of optimal P-selectin/PSGL-1 interaction using an alternative mechanism that involves P-selectin-, L-selectin-, and sLe(x)-bearing ligands...
- Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependentElena Galkina
Department of Biomedical Engineering, University of Virginia, Health Sciences Center, Charlottesville, VA 22908, USA
J Exp Med 203:1273-82. 2006..Atherosclerosis induces the recruitment of macrophages and dendritic cells that support antigen presentation...
- Early establishment of diverse T cell receptor profiles for influenza-specific CD8(+)CD62L(hi) memory T cellsKatherine Kedzierska
Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Melbourne, Australia
Proc Natl Acad Sci U S A 103:9184-9. 2006..indicates that prominent clonotypes bearing "public" or "shared" T cell receptors (TCRs) subset early into CD62L(hi) and CD62L(lo) populations...
- No detectable endothelial- or leukocyte-derived L-selectin ligand activity on the endothelium in inflamed cremaster muscle venulesEinar E Eriksson
Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
J Leukoc Biol 84:93-103. 2008..These data demonstrate that expression of L-selectin on leukocytes is insufficient for mediating rolling and efficient recruitment of leukocytes in inflammation...
- Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expressionD A Steeber
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 95:7562-7. 1998..Thus, members of the selectin and Ig families function synergistically to mediate optimal leukocyte rolling in vivo, which is essential for the generation of effective inflammatory responses...
- Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammationL G Ellies
Howard Hughes Medical Institute, Division of Cellular and Molecular Medicine, University of California San Diego, La Jolla 92093, USA
Immunity 9:881-90. 1998..These studies indicate that core 2 oligosaccharide biosynthesis segregates the physiologic roles of selectins and reveal a function for the C2 GlcNAcT in myeloid homeostasis and inflammation...
- The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: role of the EGF domain in endothelial bindingM H Siegelman
Department of Pathology, Stanford University School of Medicine, California 94305
Cell 61:611-22. 1990The lymph node homing receptor core polypeptide (mLHRc) is composed of a tandem collection of domains: a lectin domain, an epidermal growth factor (EGF) domain, and two repeats common in complement regulatory proteins...
- Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domainsM H Siegelman
Department of Pathology, Stanford University School of Medicine, CA 94305
Science 243:1165-72. 1989Isolation of a clone encoding the mouse lymph node homing receptor reveals a deduced protein with an unusual protein mosaic architecture, containing a separate carbohydrate-binding (lectin) domain, an epidermal growth factor-like (EGF) ..
- Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfateD R Coombe
Sir William Dunn School of Pathology, University of Oxford, UK
Blood 84:739-52. 1994..The data suggest that heparan sulfate on the 3T3 cell surface is a ligand for both CD45 and Mac-1, but the two molecules recognize different heparan sulfate structural motifs...
- Purification and quantification of L-selectin-reactive GlyCAM-1 from mouse serumM S Singer
Department of Anatomy, University of California, San Francisco 94143 0452, USA
J Immunol Methods 196:153-61. 1996..This material may now be used to address the biological functions of GlyCAM-1 and to further define its structural features...
- L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient miceM L Tang
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 158:5191-9. 1997..These findings delineate an important role for L-selectin in lymphocyte recruitment to cutaneous sites of inflammation...
- Role of primary and secondary capture for leukocyte accumulation in vivoE J Kunkel
Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA
Circ Res 82:30-8. 1998..Cluster formation appears to be dominated by areas of endothelium with a higher expression of E-selectin, because cluster formation is greatly reduced in E-selectin-deficient mice...
- Gene-targeted mice reveal importance of L-selectin-dependent rolling for neutrophil adhesionU Jung
Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA
Am J Physiol 274:H1785-91. 1998..We conclude that L-selectin can mediate rolling that results in sufficient leukocyte recruitment to account for the robust inflammatory response seen in E-/P- mice at later times...
- Overlapping roles for L-selectin and P-selectin in antigen-induced immune responses in the microvasculatureS Kanwar
Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
J Immunol 162:2709-16. 1999..In conclusion, leukocyte rolling is L-selectin-dependent post-Ag challenge with L-selectin and P-selectin sharing overlapping functions...
- Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectinsT Papayannopoulou
Division of Hematology, University of Washington, Seattle 98195 7710, USA
Blood 98:2403-11. 2001....
- A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivoLiLi Tu
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 169:2034-43. 2002..These results suggest that sL-selectin influences lymphocyte migration in vivo and that the increased sL-selectin levels present in certain pathologic conditions may adversely affect leukocyte migration...
- Chromosome mapping of Soa, a gene influencing gustatory sensitivity to sucrose octaacetate in miceC G Capeless
Department of Psychology, Florida State University, Tallahassee 32306 1051
Behav Genet 22:655-63. 1992..The data are consistent with a position for the Soa locus on mouse chromosome 6, 62 cM from the centromere...
- Characterization and chromosomal distribution of endogenous mouse mammary tumor viruses of European mouse strains STS/A and GR/AR Michalides
Virology 142:278-90. 1985..R. Callahan, D. Gallahan, and Ch. Kozak (1984), J. Virol. 49, 1005-1008). GR and GR.Mtv-2 furthermore contain two incomplete MMTV proviral elements, one of which is also present in STS/A...
- Functional analysis of Mel-14+ and Mel-14- early precursor cells in the adult mouse thymusL Wu
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Immunol Lett 40:89-92. 1994..This strengthens the hypothesis that one precursor cell has the potential to form all three lineages...
- DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID miceB J Hicke
NeXstar Pharmaceuticals Inc, Boulder, Colorado 80301, USA
J Clin Invest 98:2688-92. 1996..These aptamers also block L-selectin-dependent lymphocyte trafficking in vivo, indicating their potential utility as therapeutics...
- Leukocyte-endothelial cell interactions - lessons from knockout miceA R Rosenkranz
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Exp Nephrol 7:125-36. 1999..Second, we discuss models of experimental glomerulonephritis and what we have learned about leukocyte adhesion receptors in the pathogenesis of glomerulonephritis through studies in knockout mice...
- L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesisF Qian
Department of Pathology and Developmental Biology, Stanford School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 98:3976-81. 2001....
- The Trypanosoma cruzi membrane mucin AgC10 inhibits T cell activation and IL-2 transcription through L-selectinPilar Alcaide
Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Madrid, 28049 Spain
Int Immunol 16:1365-75. 2004..AgC10 binds to T cell surface through CD62L, and antibodies to CD62L inhibited T cell proliferation and IL-2 secretion and transcription as efficiently as ..
- Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitmentShihao Chen
Glycobiology Program, Cancer Research Center, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
J Exp Med 202:1679-89. 2005..These findings indicate that L-selectin-mediated NK cell recruitment plays a crucial role in the control of tumor metastasis into secondary lymphoid organs...
- B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilizationVeronique Angeli
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Immunity 24:203-15. 2006..Knowledge that DC migration from the periphery is augmented by B cell-dependent signals reveals new potential strategies to increase DC migration during vaccination...
- The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infectionShamik Ghosh
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 176:4914-22. 2006..Thus, LFA-1 (CD11a/CD18) plays an essential role in immunity to M. tuberculosis infection...
- ADAM17 deficiency by mature neutrophils has differential effects on L-selectin sheddingYing Li
Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
Blood 108:2275-9. 2006..Together, our data reveal that L-selectin's surface density on neutrophils is regulated by ADAM17, but homeostatic L-selectin cleavage is not...
- Monocyte migration to inflamed skin and lymph nodes is differentially controlled by L-selectin and PSGL-1Beatriz León
Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Universidad Autonoma, Madrid, Spain
Blood 111:3126-30. 2008....
- KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptorsMichael A Weinreich
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
Immunity 31:122-30. 2009..KLF2 regulates T cell trafficking by promoting expression of the lipid-binding receptor S1P(1) and the selectin CD62L. Recently, it was proposed that KLF2 also represses the expression of chemokine receptors...
- TLR-mediated loss of CD62L focuses B cell traffic to the spleen during Salmonella typhimurium infectionVicky L Morrison
School of Biological Sciences, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
J Immunol 185:2737-46. 2010..culture and in mice, MyD88-dependent activation of B cells via TLR2 or TLR9 causes the rapid loss of expression of CD62L by metalloproteinase-dependent shedding...
- Inducible costimulator controls migration of T cells to the lungs via down-regulation of CCR7 and CD62LTamson V Moore
Committee on Immunology and Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
Am J Respir Cell Mol Biol 45:843-50. 2011..that activated ICOS(-/-) CD4 T cells express higher concentrations of the lymph node homing receptors, CCR7 and CD62L, than do wild-type CD4 T cells, leading to a preferential return of ICOS(-/-) cells to the nondraining lymph nodes ..
- KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homingMichael L Patnode
Department of Anatomy and Program in Biomedical Sciences, University of California, San Francisco, CA 94143 0452, USA
Glycobiology 23:381-94. 2013..These results refine our understanding of the biological ligands for L-selectin and introduce a mouse model for investigating the functions of Gal6S in other contexts...
- ICAM-1 deficiency exacerbates sarcoid-like granulomatosis induced by Propionibacterium acnes through impaired IL-10 production by regulatory T cellsMasahiro Kamata
Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Am J Pathol 183:1731-9. 2013..Our results indicate that ICAM-1 is imperative for inducing regulatory T cells to produce IL-10 in vivo, which would prevent granuloma formation...
- The PSGL-1-L-selectin signaling complex regulates neutrophil adhesion under flowAnika Stadtmann
Department of Anesthesiology, Intensive Care, and Pain Medicine and 2 Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation University of Münster, 48149 Munster, Germany
J Exp Med 210:2171-80. 2013..We conclude that this is a signaling complex specialized for sensing adhesion under flow. ..
- Protective effects of fucoidan, a P- and L-selectin inhibitor, in murine acute pancreatitisAna C S Carvalho
From the Departments of Physiology and Pharmacology and Morphology, Institute of Biomedicine of Brazilian Semi arid, School of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil and NIHR Pancreas Biomedical Research Unit and Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
Pancreas 43:82-7. 2014..The objective of this study was to investigate the potential protective effects of fucoidan, an L- and P-selectin modulator, in 2 murine models of acute pancreatitis...
- Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivoJunko Matsuzaki
Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, 060 0815, Hokkaido, Sapporo, Japan
Cell Immunol 224:98-105. 2003..antigen on various subsets of mouse spleen cells, we found that Gr-1 was expressed on memory-type CD8(+)CD44(high)CD62L(high) T cells in addition to granulocytes...
- L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestineJesus Rivera-Nieves
Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
J Immunol 174:2343-52. 2005..Thus, pathogenic CD4+ T cells not only use the physiologic alpha4beta7/MAdCAM-1 pathway, but alternatively engage alpha4beta1 and L-selectin to recirculate to the chronically inflamed small intestine...
- Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin miceYukiyo Matsushita
Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
J Immunol 179:698-707. 2007..Thus, our findings indicate that ICAM-1 expression contributes to the development of skin fibrosis in TSK/+ mice, especially via ICAM-1 expressed on skin fibroblasts...
- Signals regulating L-selectin-dependent leucocyte adhesion and transmigrationAleksandar Ivetic
Membrane Cytoskeleton Signalling Group, Cardiovascular Division, British Heart Foundation, Centre of Research Excellence, King s College London, London SE5 9NU, United Kingdom
Int J Biochem Cell Biol 45:550-5. 2013....
- The gene for the ubiquitous octamer-binding protein Oct-1 is on human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on mouse chromosome 1C L Hsieh
Howard Hughes Medical Institute, Stanford, California
Genomics 6:666-72. 1990..There were no recombinants among 26 strains with Ly-22 and 1 recombinant among 24 strains with Ltw-4. The gene symbol is OTF1 for humans and Oct-1 for mouse...
- An alternatively spliced Muc10 glycoprotein ligand for putative L-selectin binding during mouse embryonic submandibular gland morphogenesisM Melnick
Laboratory for Developmental Genetics, University of Southern California, 925 W 34th Street, DEN 4266, CA 90089 0641, Los Angeles, USA
Arch Oral Biol 46:745-57. 2001..As the primary role of L-selectin is to mediate cell adhesion and its ligands are mucin-like glycoproteins, it is suggested that this embryonic low molecular-weight mucin be termed MucCAM...
- Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytesJennifer Czarneski
Department of Microbiology, University of Pennsylvania, Philadelphia, USA
Eur J Immunol 32:945-56. 2002..These results suggest that adhesion molecules other than beta7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection...
- Absence of L-selectin delays mucosal B cell responses in nonintestinal effector tissuesKeri L Csencsits
Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
J Immunol 169:5649-59. 2002..Yet, these increases in CONALT AFC correlated with restoration of immunity in L-Sel(-/-) nasal passages and reproductive tracts...
- Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectinsDaniela Taverna
Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 101:763-8. 2004..These results implicate cells of the innate immune system, macrophages or perhaps natural killer cells, in each case dependent on integrins and selectins, in tumor suppression...
- Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by fever-range thermal stressMichelle M Appenheimer
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263 0001, USA
Eur J Immunol 37:2856-67. 2007....
- Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cellsBritt E Anderson
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA
Blood 111:5242-51. 2008..One potential explanation for the inability of T(EM) to cause GVHD is that T(EM) lack CD62L and CCR7, which are instrumental in directing naive T cells (T(N)) to lymph nodes (LN) and Peyer patches (PP), ..
- Identification of novel isoforms of mouse L-selectin with different carboxyl-terminal tailsYuko Furukawa
The 21st Century Center of Excellence Program, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
J Biol Chem 283:12112-9. 2008..These results suggest that alternative splicing is one mechanism for generating functional diversity in L-selectin...
- Transcriptional regulation of mouse L-selectinXitong Dang
Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Biochim Biophys Acta 1789:146-52. 2009..Silencing the expression of Sp1 by siRNA significantly decreased sell promoter activity in EL4 cells. We conclude that sell transcription is regulated by Mzf1, Klf2, Sp1, Ets1, and Irf1...
- Requirement of L-selectin for gammadelta T lymphocyte activation and migration during allergic pleurisy: co-relation with eosinophil accumulationMaria Fernanda S Costa
Laboratório de Farmacologia Aplicada, Departamento de Farmacologia Aplicada, Farmanguinhos, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
Int Immunopharmacol 9:303-12. 2009..Part of these cells expressed CD62L, which increased on gammadelta T cell surfaces obtained from lymph nodes after ovalbumin (OVA) challenge...
- Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptorYann M Kerdiles
Molecular Biology Section, Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, California 92093 0377, USA
Nat Immunol 10:176-84. 2009..These data suggest that Foxo1 regulates the homeostasis and life span of naive T cells by sensing growth factor availability and regulating homing and survival signals...
- Differentiation of central memory CD8 T cells is independent of CD62L-mediated trafficking to lymph nodesThomas C Wirth
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
J Immunol 182:6195-206. 2009b>CD62L (L-selectin) is a key regulator of T cell trafficking, and its surface expression on activated T cells is modulated to control T cell access to lymph nodes after acute infections...
- Platelet, not endothelial, P-selectin expression contributes to generation of immunity in cutaneous contact hypersensitivityRalf J Ludwig
Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Am J Pathol 176:1339-45. 2010..Our observations indicate that platelet, not endothelial, P-selectin contributes to generation of immunity in DNFB-induced contact hypersensitivity...
- Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expressionLaure Guenin-Macé
Institut Pasteur, Unité de Pathogénomique Mycobactérienne Intégrée, 75015 Paris, France
Proc Natl Acad Sci U S A 108:12833-8. 2011..Our results identify T-cell homing as a biological process targeted by mycolactone. Moreover, they reveal a mechanism of control of CD62-L expression involving the miRNA let-7b...
- Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNAR J Oakey
Department of Medicine, Duke University Medical Center, Durham, NC 27710
Hum Mol Genet 1:613-20. 1992..These data support the use of comparative mapping in physical map construction and further suggest the value of using mouse genetics to help define human disease loci...
- Genetic linkage analysis in recombinant inbred mice of P40, a putative clone for the high-affinity laminin receptorP J Douville
Centre for Research in Neurosciences, Montreal General Hospital, Quebec, Canada
Mamm Genome 3:438-46. 1992..These P40 loci comprise part of a multimember gene family that is well dispersed in the mouse genome...
- Characterization of the murine homing receptor gene reveals correspondence between protein domains and coding exonsD J Dowbenko
Department of Immunobiology, Genentech, Inc, South San Francisco, California 94080
Genomics 9:270-7. 1991....
- Cloning of a lymphocyte homing receptor reveals a lectin domainL A Lasky
Department of Cardiovascular Research, Genentech, Inc South San Francisco, California 94080
Cell 56:1045-55. 1989..This result supports a novel mechanism for the distribution of lymphocyte populations to various lymphoid organs...
- Genetic relationships of Mlsa among polymorphic loci on distal mouse chromosome 1M F Seldin
Department of Medicine, Duke University Medical Center, Durham, NC 27710
J Immunogenet 15:59-66. 1988..The identification of multiple polymorphic loci in the region of Mlsa should allow precise gene localization and assist in efforts to clone this gene...
- Endogenous xenotropic murine leukemia virus-related sequences map to chromosomal regions encoding mouse lymphocyte antigensJ C Wejman
J Virol 50:237-47. 1984..These studies indicate that xenotropic proviral loci are located on many different mouse chromosomes and may be useful markers for molecularly cloning and characterizing regions of the mouse genome important in lymphocyte development...
- Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitisS J Simpson
Division of Immunology Beth Israel Hospital, Harvard Medical School, Boston, MA 02215, USA
Eur J Immunol 25:2618-25. 1995..In light of these findings, we propose that infiltrating CD4+, but not CD8+ T cells are central to the inflammation observed in the intestinal mucosa in IL-2null colitis...
- Mapping of the gene for high-density lipoprotein binding protein (Hdlbp) to proximal mouse chromosome 1R C LeBoeuf
Department of Medicine, University of Washington, Seattle 98195
Genomics 23:296-8. 1994
- Endogenous nonecotropic proviruses mapped with oligonucleotide probes from the long terminal repeat regionW N Frankel
Jackson Laboratory, Bar Harbor, Maine 04609
Mamm Genome 5:275-81. 1994..Together with proviruses identified previously with env probes, the LTR probe-reactive elements represent the majority of endogenous murine leukemia proviruses in the mouse genome...
- Cloning of the cDNA for rabbit L-selectin and expression of recombinant protein with a kinase target site to facilitate radiolabelingJ Qian
Department of Internal Medicine, University of Michigan, Ann Arbor 48109 0531, USA
Biochem Biophys Res Commun 225:406-12. 1996..Amino-terminal peptide sequencing of recombinant L-Selectin confirmed that the signal peptide had been removed at the expected site...
- Neutrophil margination, sequestration, and emigration in the lungs of L-selectin-deficient miceN A Doyle
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Clin Invest 99:526-33. 1997..coli-induced pneumonia, and in the accumulation of neutrophils within noncapillary microvessels when induced by either intravascular complement fragments or..
- The value of gene 'knock-out' for assessing the role of cell adhesion molecules in renal diseaseA McGinty
Department of Medicine and Therapeutics, Mater Misericordiae Hospital, University College Dublin, Ireland
Nephrol Dial Transplant 14:27-9. 1999
- Mobilization of stem/progenitor cells by sulfated polysaccharides does not require selectin presenceE A Sweeney
Department of Medicine, Division of Hematology, University of Washington, Seattle, WA 98195 7710, USA
Proc Natl Acad Sci U S A 97:6544-9. 2000..As similarly sulfated compounds were ineffective in vivo, the data also underscore the fact that polysaccharides with similar structures may elicit diverse in vivo effects...
- Role of selectins in experimental Staphylococcus aureus-induced arthritisM Verdrengh
Department of Rheumatology, University of Goteborg, Sweden
Eur J Immunol 30:1606-13. 2000..aureus-induced arthritis: on the one hand, blockade of these selectins leads to less severe arthritic lesions in the initial stage of the disease; on the other, delayed recruitment of phagocytes decreases the clearance of bacteria...
- Pathophysiologic importance of E- and L-selectin for neutrophil-induced liver injury during endotoxemia in miceJ A Lawson
Department of Pharmacology, Pharmacia and Upjohn, Inc, Kalamazoo, MI, USA
Hepatology 32:990-8. 2000..Therefore, we conclude that blocking E-selectin or eliminating this gene may have protected against Gal/ET-induced liver injury in vivo by inhibiting the full activation of neutrophils during the transmigration process...
- Impaired mucosal immunity in L-selectin-deficient mice orally immunized with a Salmonella vaccine vectorD W Pascual
Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
J Immunol 167:407-15. 2001..This evidence shows that L-Sel is important for development of mucosal immunity, and absence of L-Sel is protective against salmonellosis...
- Dermal and pulmonary inflammatory disease in E-selectin and P-selectin double-null mice is reduced in triple-selectin-null miceR G Collins
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Blood 98:727-35. 2001..The occurrence of skin and pulmonary disease in E/P double-mutant mice but not E/L/P triple-mutant mice suggests that deficiency of L-selectin alters the inflammatory response in E/P mutants. (Blood. 2001;98:727-735)..
- Cutting edge: dichotomy of homing receptor dependence by mucosal effector B cells: alpha(E) versus L-selectinK L Csencsits
Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
J Immunol 167:2441-5. 2001..This study provides evidence for compartmentalization of the common mucosal immune system into "intestinal" vs "nonintestinal" effector sites...
Research Grants18
- Structure/Functional Characterization of vWF-A1 DomainTHOMAS DIACOVO; Fiscal Year: 2007..Information from these studies may aid in the design of antithrombotics with specific kinetic properties that can compete with the native-ligand pair. ..
- Novel Dendritic Cell Chemoattractant and ReceptorEugene Butcher; Fiscal Year: 2009..abstract_text> ..
- Mucosal Therapy for AutoimmunityDavid Pascual; Fiscal Year: 2008..Studies in Specific Aim 3 will determine the responsible dendritic cell subset that supports regulatory T cell development. ..
- MUCOSAL TRANSGENE VACCINATION FOR HIVDavid Pascual; Fiscal Year: 2003..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity via the common mucosal immune system. ..
- TARGETED DNA DELIVERY FOR SALIVARY IGA RESPONSESDavid Pascual; Fiscal Year: 2004..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity in the oral cavity and SALT. ..
- Mucosal Vaccines for PlagueDavid Pascual; Fiscal Year: 2006..pestis challenge. From these studies, we will produce efficacious vaccines to plague, as well as a supporting vaccine regimen, that will confer protective immunity in the mucosal and systemic immune compartments. ..
- MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERYDavid Pascual; Fiscal Year: 2009..Thus, from these studies we will learn the specific mechanisms induced by this anti-inflammatory vaccine. ..
- Mucosal Lymphocyte Homing in the Head and NeckDavid Pascual; Fiscal Year: 2008..n. challenge with CT. From this work, we will learn how routes of immunizations can be used to effectively target vaccines to nonintestinal mucosal sites. ..
- GLOBIN SWITCHING AND ERYTHROID DIFFERENTIATIONThalia Papayannopoulou; Fiscal Year: 2002....
- Tolerogenic DC as Therapeutic Agents in GVHDEugene C Butcher; Fiscal Year: 2010..Together, these studies will define in detail the potential of CCR9+ pDCs to suppress deleterious effects of GVHD in settings modeling situations in which human patients encounter pathogenic GVHD responses. ..
- Intestinal Lymphocyte TraffickingEugene Butcher; Fiscal Year: 2009....
- P13Kdelta Modulation of Neutrophil TraffickingTHOMAS DIACOVO; Fiscal Year: 2008..Moreover, our results will define a new role for class I PBKs, regulation of the adhesive properties of inflamed endothelium. ..
- ENDOTHELIAL CELL BIOLOGY IN INFLAMMATIONEugene Butcher; Fiscal Year: 2008..The proposed studies should expand our understanding of the critical role of the vascular endothelium in regulating lymphocyte trafficking during normal and pathologic immune responses. ..
- VASCULAR-MONOCYTE ADHESION MOLECULE IN ATHEROGENESISEugene Butcher; Fiscal Year: 2002..The proposed studies will elucidate the structure of this novel vascular receptor and its role in monocyte recruitment in atherogenesis. They may lead to new approaches to the regulation of the atherogenic process. ..
- CHEMOATTRACTANT SIGNALING TO LEUKOCYTE INTEGRINSEugene Butcher; Fiscal Year: 2001..These studies should define signaling mechanisms regulating the adhesion of leukocytes and other cells, and may lead to novel therapeutic approaches for the control of neoplastic and inflammatory diseases ..
- Investigation of Nod2: Implications for UveitisHolly Rosenzweig; Fiscal Year: 2008..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
- BIOLOGICAL PROPERTIES AND REGULATION OF STEM CELLSThalia Papayannopoulou; Fiscal Year: 2009..We believe that the proposed studies will enhance our understanding and provide a more comprehensive picture of the influence of <x4 integrins on prenatal and postnatal hematopoiesis. ..
- Conference on Leukocyte TraffickingEugene Butcher; Fiscal Year: 2004..abstract_text> ..


text:
Objectives Edit
Speak with Nozdormu at the End Time.
Description Edit
Nozdormu, the bronze aspect, has asked for help from the champions of the <Alliance/Horde>. You are on his short list. I can share few other details.
It is uncharacteristic of my master to request the assistance of mortals, but I suppose that all things change with time... even the Aspect of Time himself.
He awaits you at the End Time, in the distant future. I can help you to travel there, if you so choose.
Completion Edit
<name>, you have arrived. This is good. I apologize for bringing you to this strange place, and under such suspicious circumstances.
I have a good reason for doing so.
We are going to kill Deathwing. And I require your aid.
Rewards Edit
You will receive:
- 1 65 50
Notes Edit
- Alliance players can find Coridormi[49.4, 87.4] within the Mage Quarter of Stormwind City.
- Horde players can find Ziradormi[48.8, 70.4] within Grommash Hold in Orgrimmar.
Patches and hotfixes Edit
Patch 4.3.0 (29-Nov-2011): Added.
External linksEdit


text:
Occam's razor is a problem-solving principle attributed to William of Ockham, who was an English Franciscan friar, scholastic philosopher and theologian.
The principle can be interpreted as stating 'Among competing hypotheses, the one with the fewest assumptions should be selected.' Or more simply put, 'the simplest answer is most often correct." But of course, sometimes it is not.
The recent NHA announcement that they are slashing headcount has come as something of a surprise. While the issue of how our Regulator is funded (by the Operator) has been hotly debated over the years, despite rather obvious signs to the contrary, there has always been strenuous denial that the Operators placed any sort of financial restraint on the NHA.
What the figures say
The NHA's 2016 Annual Report states that Revenue is up 9.3% from 2015-2016. Expenditure is also up, but only 4.4% and while the NHA posted a loss, it was R0.36m for 2016, instead of R6.9m in 2015, so the balance sheet seems to be improving.
Mr Barends has given repeated assurances that he has the full support of the Operators and unlike his predecessors, has had none of the austerity measures of the past imposed on him. So it begs the question, why the drastic cuts?
It is fairly common knowledge that there has not been a permanent NHA representative in Kimberley for a number of years now. I would also venture that our existing Stipes were pretty thinly stretched and that good people are hard to come by. Indeed we saw the excellent Mr McGillivray – specifically drafted in to help improve matters – leave because we could not afford to remunerate him as well as other jurisdictions.
On top of race day duties, there are starting procedures, census checks, identifying horses in their various yards, managing the movement of horses, retirement of horses, processing geldings, changes of ownership, random inspections, sales identification and so on to carry out. The job requires skill in reading races, handling enquiries, dealing with specimens, inspecting runners on parade, liaising with veterinary staff, members of the media and the public, jockeys, trainers and owners, etc. In short, it is not something one learns overnight. Indeed, horses are a discipline in which one never stops learning, which is one of the aspects that makes it so damn compelling.
South African Stipes lodge far fewer objections than their international counterparts (for reasons unknown), and while it is an unenviable task at the best of times, there is sufficient noise from punters, jockeys, trainers and owners alike to give the impression that overall the status quo was not considered satisfactory. If the current restructure is indeed, as being stated, an exercise towards greater efficiency and effectiveness, it would seem that we need to INCREASE rather than REDUCE the number of hands on deck.
More numbers
However the recent cuts have seen redundancies – which means that those positions are not allowed to be filled by other individuals – and means we will need to cope on the numbers we are left with.
For the sake of clarity, that means 5 Stipes to cover Central Provinces, 4 Stipes for KZN, 3 Stipes for the Western Cape and 3 in the Eastern Cape. According to Mr Barends, "Stipendiary Stewards will focus more on the primary functions of a steward and other functions can be redistributed to other staff and/or part time staff."
The NHA has also seen fit to do away with investigating officers in each province and we will be reduced to one on a national basis. Given that we race 364 days out of 365, that seems a pretty big job.
Our handicapping complement has been reduced from 4 to 3.5. Given that we have approximately 7000 individual runners per season (according to the NHA's snazzily printed and bound 2016 Annual Report) that leaves around 2000 horses per handicapper. Of course, MR's need adjusting / re-evaluating after every single race and borrowing some (admittedly slightly dated) info from the SA Racing Fact Book, it seems we have around 45,000 starters per season. That leaves around 12,800 starts per handicapper.
Lastly, we have lost some of our stud book staff. We reportedly have an annual foal crop of around 3200 foals per year, 2800 mares (this number has to be nonsense given that we appear to have 400 more foals per year than we have mares), 85 stallions, and then add in breeders registrations, name changes, ownership registrations, issuing of passports, etc. I have always found the Stud Book staff to be enormously helpful and friendly, but I know that a number of people do have problems getting paperwork processed.
When quizzed on the changes, Mr Barends stated "These are the changes I've made after a year in the job and therefore having a better understanding of what's required." While I admire his chutzpah, Mr Barends is, by his own admission, not a racing man, so one would have to assume that these decisions were made with the full support and endorsement of the NHA Board (Andy O'Connor – replaced by Ken Truter as Chair, Lyndon Barends as CEO, Cecil Beyleveld, J J du Toit, Arnold Hyde, Roy Moodley, Rodney Trotter and Jonathan Witts-Hewinson). While these are all perfectly fine gentlemen, I have not seen too many rolling up their sleeves to watch patrol films or shepherd horses around on a race day, so one has to wonder at the practicality behind the decision-making and again, the reasoning behind it.
However, there is contingency planning in place and Mr Barends says, "In future we will implement a cadet system (internship) from which we will be able to recruit above average performers."
While I don't mean to be awkward, given the fact that the NHA did not exactly receive glowing reports from most quarters with their previous set of staff, is it really credible to expect us to swallow that a cadet system will produce 'above average performers'? Unless we are going to follow the SA schooling system and simply drop the average to suit our needs….
More numbers
To look at these numbers in practice, I reached for my copy of the NHA's annual report again. While it is tricky to get a handle on how many horses we have per centre, the report states there are approximately 1600 horses in KZN and around 1300 horses in the Western Cape. Individual figures were not listed for PE, Gauteng and Kimberley, but given that we have around 7000 individual runners per season, I would guess the balance would be spread across the remaining centres. For argument's sake, let's divvy the remaining 4000 horses up and allocate 2000 to Gauteng, 1000 to PE and 1000 to Kimberley (these are thumb suck figures, but it's mainly for the sake of illustration).
This indicates that the Western Cape is allocating 3 stipes for 1300 horses, or 433 horses per Stipe. In KZN we have 1600 horses and 4 Stipes, making approximately 400 horses per Stipe. If we use my projected 2000 horses in Gauteng to their 5 Stipes, again that leaves around 400 horses per Stipe (however, we have not calculated in the fact that these good people also serve Kimberley). We have 3 Stipes to the Eastern Cape at around 1000 horses, these guys have 333 horses each. There is no team for Kimberley, and those horses (and duties) are covered by the Central Provinces team, meaning that they each get an additional 333 horses on top of their existing 400.
We have 150 trainers, 103 assistant trainers, 157 stable employees, 104 jockeys, 14 jockey agents and 22 apprentice jockeys and approximately 2800 owners. That brings us to a total of around 3350 individuals. With a total of 15 Stipes nationally, that means approximately 223 people per Stipe.
Add on top of that the fact that most staff are split across multiple training centres and factor in things such as flight / travel costs (and the time needed to get around), race day duties, sales duties, pens practice, yard visits and all the paperwork, meetings, phone calls and day to day nonsense and frankly, I'm starting to get a little worried.
A few inconvenient facts
It is a fact of life that people go on holiday, take sick leave or personal leave and as we have seen, our NHA top brass also seem to have a large number of international commitments, meaning that someone has to man the fort at home. We also need to factor in multiple meetings per day, as well as the fact that we are currently in the throes of our feature season in Gauteng with the Durban season just about to get under way.
Some of our major race days have anywhere up to 12 races on the card and if we optimistically assume that these have good sized fields – let's say 14 runners per race, that's a total of around 170 horses on a given big feature day which as we have seen with our new Sun Met extravaganza and Champions Day, offer the biggest prize money (and therefore pressure and potential for things to go wrong). Ai karamba.
The horse will tell you
I like to say that most of my life lessons come from horses, so here is another great one that I sadly learnt the hard way from the good old school of hard knocks. It reads 'Green plus Green equals Black and Blue". It is usually applied to newbie or 'green' horse enthusiasts taking on equally green horses. The result usually means the 'black and blue' of bruises – physical as well as bruises to pride and ego.
However, horse people are notoriously stubborn and also notoriously optimistic about their levels of proficiency (we've all been there). I found a wonderful article dealing with exactly this situation. The author wrote, "Without a doubt, I am a green rider. I grew up riding western, and, after a very long break, bought an english saddle and took up jumping about two years ago. Shortly thereafter, I purchased a green horse. If I could go back in time, what would I tell myself? Based on my goals, laid out succinctly in my author bio below, I would say: Run. Do not pass go, do not collect $200. Green is not your answer. You want to find a distance? Get a schoolmaster. You want a pretty ribbon? Get a horse who has earned them before. You want to conquer your show anxiety? You sure aren't going to do it with a horse who is at her first ever competition. In retrospect it seems obvious."
Not that it is necessary, but we have been reminded that our industry is under financial pressure. We cannot afford mistakes. While hindsight is an exact science, foresight is not.
The 2017 KZN champions season themed 'The Colour Of Magic' is upon us. Here's hoping we get to enjoy the full spectrum and that our new efficient and effective NHA team does not restrict us to Black and Blue.


text:
|Clerical Local 318 / State employees
Dec. 7: Online Day of Solidarity With Jobless Workers
Join us Dec. 7 for the AFL-CIO Online Day of Solidarity with jobless workers. Here's how:
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text:
Quotations about Reading, Books and Authors
"Libraries promote reading.
Reading promotes understanding.
Understanding reduces conflict and promotes peace.
Plum Johnson
"No person who can read is ever successful at cleaning out an attic."
Ann Landers
"I think it is impossible to reach your full potential as a human being without being a reader."
LeVar Burton
"A reader lives a thousand lives before he dies.
The man who never reads lives only one."
"We read books to find out who we are. What other people, real or imaginary, do
and think and feel is an essential guide to our understanding of what we ourselves are and may become."
Ursula K. LeGuin
"A truly great book should be read in youth, again in maturity and once more in old age,
as a fine building should be seen by morning light, at noon and by moonlight."
Robertson Davies
"Books, to the reading child, are so much more than books -
they are dreams and knowledge, they are a future, and a past."
Esther Meynell
"If you have a garden and a library, you have all you need."
"A room without books is like a body without a soul."
both by Cicero, Roman philosopher
"Books, the children of the brain."
Jonathan Swift
"O, there is lovely to feel a book, a good book, firm in the hand, for its fatness holds rich promise, and you are hot inside to think of good hours to come."
Richard Llewellyn (page 464 - How Green Was My Valley)
"We all need our inspiration refreshed regularly - and the way to get it is to turn to inspiring friends and inspiring books."
Andrei Codresu
"To learn to read is to light a fire; every syllable that is spelled out is a spark."
Victor Hugo
"Books are a uniquely portable magic." and
"If you want to be a writer, you must do two things above all others:
read a lot and write a lot."
Stephen King
"Read. Read. Read.
Write. Write. Write."
Margaret Atwood
"The finest thing we can do in life is to grow a soul and then use it in service of humankind. Writers foster the growth of reader's souls, and the best soil for growth is love. Writing can be love made visible. In the end, one of our best ways to truly change readers is to love them. We can create a world in which those who know teach those who wish to learn. We writers may not live to see the changes that we work for, but readers will enjoy the shade of the trees we have planted."
Mary Pipher - "Writing to Change the World"
"Reading is sometimes thought of as a form of escapism, and it's a common turn of phrase
to speak of getting lost in a book. But a book can also be where one finds oneself; and
when a reader is grasped and held by a book, reading does not feel like an escape from life
so much as it feels like an urgent, crucial dimension of life itself."
Rebecca Mead
"Reading fiction is important. It is a vital means of imagining a life other than our own,
which in turn makes us more empathetic beings."
Anne Patchett
"You start dying slowly
if you do not travel,
if you do not read......."
- from the poem 'You start dying slowly' by Pablo Neruda
"I find television very educating. Every time somebody turns on the set,
I go into the other room and read a book."
Groucho Marx
"Give me books, fruit, French wine and fine weather
and a little music........." John Keats
"What is reading, but silent conversation."
Charles Lamb
"Reading good books ruins you for enjoying bad books."
from The Guernsey Literary and Potato Peel Pie Society
by Mary Ann Shaffer and Annie Barrows
"I am a part of all I have read." John Kieran
"Develop interest in life as you see it; in people, things, literature, music -
the world is so rich, simply throbbing with rich treasures,
beautiful souls and interesting people. Forget yourself." Henry Miller
"There is no friend as loyal as a book." - Ernest Hemingway
"One of the greatest gifts to give a child is the love of reading." - anon
"I declare after all there is no enjoyment like Reading!
How much sooner one tires of any thing than of a book."
"If a book is well-written, I always find it too short."
"If I go too long without picking up a good book, I feel like I've done nothing useful with my life."
Jane Austen
"Books are the quietest and most constant of friends;
they are the most accessible and wisest of counselors,
and the most patient of teachers." Charles William Elliot
"Five years from now you will be pretty much the same as you are today
except for two things: the books you read
and the people you get close to." Charles Jones
"The man who does not read good books has no advantage
over the man who cannot read." Mark Twain
"We read books to find out who we are. What other people, real or imaginery,
do and think and feel is an essential guide to our understanding of what we ourselves are or may become."
Ursula K. LeGuin
"When you sell a man a book, you don't sell him 12 ounces of paper and ink and glue -
you sell him a whole new life." Christopher Morley
"You don't have to burn books to destroy a culture.
Just get people to stop reading them." Mohandas Gandhi
"Be careful about reading health books -
you may die of a misprint." Mark Twain
"A book is a path of words which takes the heart
in new directions." John O'Donohue
"Reading gave me hope." Oprah Winfrey
"Life is full of wonderful passions that come and go over the years,
but the only one that will never let you down is reading." Miss Manners
"The greatest gift is a passion for reading. It is cheap, it consoles, it distracts,
it excites, it gives you the knowledge of the world and experience of a
wide kind. It is a moral illumination." Elizabeth Hardwick
"Read the best books first, or you may not have a chance to read them at all." Thoreau
"You cannot open a book without learning something." - and
"No matter how busy you are, you must find time for reading,
or surrender yourself to self-chosen ignorance."
both are quotes by Confuciuc,Chinese Philosopher 551 BC-479 BC
"Some books are to be tasted, others to be swallowed,
and some few to be chewed and digested."
Francis Bacon, English philosopher 1561-1626
"If I could always read, I should never feel the want of company."
Lord Byron, English Poet 1788-1824
"The reading of all good books is like a conversation with the finest
minds of past centuries." Rene Descartes
"A book lying idle on a shelf is wasted ammunition.
Like money, books must be kept in constant circulation.
Lend and borrow to the maximum - of both books and money!
But especially books, for books represent infinitely more than money.
A book is not only a friend, it makes friends for you.
When you have possessed a book with mind and spirit, you are enriched.
But when you pass it on, you are enriched threefold." Henry Miller
"Reading is a basic tool in the living of a good life." Mortimer Adler
"Just the knowledge that a good book is awaiting one at the end of a long day
makes that day happier." Kathleen Norris
Outside of a dog, a book is man's best friend.
Inside of a dog, it's too dark to read. Groucho Marx
Good friends, good books and a sleepy conscience:
This is the ideal life. Mark Twain
"The greatest gift that you can give to children is your time.
The best way to spend that time is by reading with them."
"If a book is a journey, each word is a stepping stone."
M. J. Lake
"If you can read you can cook."
"I lived in books more than I lived anywhere else."
"Write the book you want to read."
"Reading is dreaming with eyes wide open."
"When in doubt, go to the Library."
"When the week-end comes, I'll be booked."


text:
The Week That Was Again.
May 5. Alison's birthday. Went out for Shakey's Pizza. Bought a nice cake for cell tonight.
May 6. Classes, classes and yet more classes. Tired.
May 7. YET MORE classes. Pianist was late. The bus she travelled in sort of crawled to KL. When she got here, I had to rush the Grade 5 class. Poor Zheng Yu. I thought he was about the collapse. If I was not teaching, I was cleaning up the studio and trying to make it presentable for exams. Tired.
May 8. 1st day exams. Discovered this year's examiner takes her job VERY seriously. So seriously that she frowns while concentrating. Oh but she smiles when she remembers to. A little on the strict side - no noise, no fidgeting no nothing.Tired.
May 9. Another day of exams. Tired, tired................. Took examiner to Royal Selangor. The annual pilgrimmage to that place for me.
May 10. LAST day of exams! Yahoo!!!! Short day. Dropped examiner back to hotel, went to Sungai Wang/ Low Yat area and spent a bomb. Took Cui Xin and Bee Hong to lunch. VERY nice. Came home and realised the dirty laundry piled up high!Tired.
May 11. Hung out the washing. Placed another load to wash. Discovered the 2nd load caked with MUD. Stupid waterworks decided to clean something and stupid me did not know. Taps dry. Cannot clean the muddy wash. 1st wash on the line drenched in rain when I had to step out for a while. Cannot cook - no water. WHAT A DAY OFF!Tired.
May 12. Window shopping the whole day. Sunny's birthday dinner. Heavy German meal. After that meal, I feel very German gestapo fraulein-like. Tired
May 13. Classes, classes and MORE classes again. New work, have to teach in detail. TIRED!
May 14. Another PTS VISIT in the afternoon. Did I mention TIRED????????????


text:
Please email the following information to: firstname.lastname@example.com
1. Position title
2. Position's description
3. Contact information
4. A logo of your institution (if available)
5. A date to remove the post or number of weeks you would like the post to stay on-line.
Two postdoctoral positions are currently available in the Greenberg laboratory in the Department of Biological Sciences at Wayne State University. We utilize the powerful genetic, molecular, and cell biological tools of the yeast system and relevant mammalian cell cultures to elucidate the cellular functions of two essential lipid pathways. One project is to understand the mitochondrial and cellular functions of cardiolipin, the signature lipid of the mitochondrial membrane. This project focuses on the role of cardiolipin in cellular energy metabolism, the function of cardiolipin remodeling, and the link between cardiolipin and the life-threatening genetic disorder, Barth syndrome. The second project seeks to understand the molecular mechanisms underlying regulation of inositol synthesis, the essential functions of inositol phospholipids and metabolites, and the cellular consequences of inositol depleting drugs. These studies have implications for understanding the therapeutic mechanisms of action of mood stabilizing drugs. Further information can be found at http://www.clas.wayne.edu/greenberg/. Applicants should submit a cover letter, CV, and the names and email addresses of three references to Dr. Miriam L. Greenberg (firstname.lastname@example.com).
Posted: 8-7-2017
Postdoctoral Researcher – Full Time
Department: EMB – Embryology
Location: Baltimore, MD
Salary: NIH-NRSA Stipend Scale
Job Summary:
A postdoctoral position to identify small molecules and genetic pathways that regulate lipid metabolism is available immediately in the laboratory of Dr. Steven Farber at the Carnegie Institution for Science, Department of Embryology, in Baltimore, MD.
The position requires a highly-motivated applicant with a strong interest in questions of lipid metabolism. The position involves conducting a state-of-the-art pharmacogenetic screen for modifiers of lipoprotein metabolism and studies at the cellular and subcellular levels to characterize zebrafish with mutations in genes affecting digestive organ lipid uptake, metabolism, transport and storage.
The Farber laboratory performs studies at the nexus of cell biology, metabolism and digestive physiology. The Carnegie Department of Embryology follows the current NIH-NRSA postdoctoral stipend scale and our postdoctoral benefit package includes health care, sick leave, annual leave, parental leave, life insurance, and paid holidays.
An ideal candidate will be creative, industrious, have excellent communication skills, and enjoy working independently as well as collaboratively. A Ph.D. in a related field and fluency in spoken and written English is required for the position.
To apply:
A CV, statement of research interest, and contact information for three references are required to apply. Apply online at: https://jobs.carnegiescience.edu/jobs/emb/
Additional information:
The Department of Embryology is one of six departments comprising the Carnegie Institution for Science. The department functions as a private, non-profit research institute affiliated with the Johns Hopkins University and is located adjacent to the JHU Homewood campus in Baltimore, MD. The department consists of 10 laboratories studying a variety of questions in cell and developmental biology. For more information about the Department, visit http://emb.carnegiescience.edu/
Carnegie is an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of gender, race/ethnicity, protected veteran status, disability, or other protected group status.
Posted: 7-11-2017
A postdoctoral position is available in the Carman laboratory at the Center for Lipid Research within the Institute for Food, Health, and Nutrition at Rutgers University. The laboratory is known for its studies on the molecular genetics and biochemical regulation of yeast lipid metabolism. The current focus is to understand mechanisms by which membrane phospholipids are synthesized along with the synthesis of triacylglycerol (fat). Research projects include the posttranslational modifications (e.g., phosphorylation, dephosphorylation, and ubiquitination) of the phosphatidic acid phosphatase (Pah1, lipin) and its regulator protein phosphatase Nem1-Spo7. Additional information about the Carman laboratory that includes reprints of recent publications is found at http://foodsci.rutgers.edu/carman/index.html. The applicant is expected to have expertise in biochemistry and/or molecular biology. Submit a cover letter with your career objectives, a CV, and the email addresses of three references to Dr. George M. Carman (firstname.lastname@example.com). Rutgers University is an Equal Opportunity/Affirmative Action Employer.
Posted: 5-24-2017


text:
Try these three vocal exercises, which are demonstrated with the Brett Manning method. These will really help you improve fast if you've got the basics of singing down.
The one thing I like about this video is how he makes the lessons very practical. He shows how even his own voice struggles at times and how it takes a while of doing specific exercises to regain his vocal chords and octave range. You can learn here more at the Singing Success review page.
Breathing Exercises – One of the most effective vocal exercises is a simple breathing exercise.
You can start by sitting down in a chair or comfortable position and slowly inhale deeply.
After this, slowly exhale through your mouth. Do this for a few minutes. I promise this has a lot to do with singing!
After this, start closing your mouth and exhale between your tongue and top teeth. You will hear a hissing sound. This is good. You are training your diaphragm to hold the inhale for longer periods. Your goal is to increase the time it takes to exhale with the hiss slowly.
Trust me, after you do this for a while, you can exhale once for minutes at a time! Now, can you see how you could learn to hold notes longer while singing? This is a great way to also become more serene.
Serenity never hurt anyone! This can become a very calming exercise you can practice daily just for five minutes and your benefits go far beyond singing.