text:
Howard College sustainable energy
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Get info about Howard College sustainable energy, and registering in a elective technical programs. Which college degrees give you the best chances of finding employment after graduation? The field of engineering requires either an associates degree for entry-level technical workers, or a bachelors degree for professional engineers. Concentrating on Howard College sustainable energy, for example, you may gain an advantage in job recruiting on-campus. Check with the solar cell technology department for course registration deadlines, and renewable energy program requirements. Please use the form above to request admissions info for Howard College
The Office of Energy Efficiency and Renewable Energy (EERE) leads public research in innovative solar power technologies. Photovoltaic arrays, or PV for short, harness the sun's power and turn it into electricity. When the sun shines onto a solar panel, photons are absorbed by the cells in the panel, which creates an electric field across the layers. Photovoltaic arrays must be mounted at a fixed angle determined by the local latitude. Alternatively, automatic mechanisms may be installed to move panels to track the sun across the sky, which increases absorbtion of solar energy.
Inverters are used to convert the direct current (DC) electricity generated by solar photovoltaic modules into alternating current (AC). Finally, large batteries allow for the storage of solar photovoltaic energy when bad weather blocks sunlight. Organic PV, or OPV, cells are composed of carbon-rich polymers and can be tailored to enhance a specific function of the fuel cell, such as sensitivity to a certain type of light. This technology has the theoretical potential to provide electricity at a lower cost than silicon or fuel cell technologies. Concentration PV, also known as CPV, focuses sunlight onto a solar cell by using a mirror or lens. By focusing sunlight onto a small area, less PV material is required. This passive solar technology uses mirrors to reflect and concentrate sunlight onto receivers that collect solar energy and convert it to heat, which can then be used in fuel cell design to produce electricity. Beyond major requirements within the solar cell technology department, you may consider Missouri State University West Plains 3D printers as an adjunct to your primary course of study.
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It's ALMOST Friday...
I'm a few hours shy of it...
BUT Praise Jesus, Friday is here!
This week has been...different (to say the least).
It's the first time Dannika has been EXTREMELY clingy to me since Nick has been in the field.
She's normally really good with separation.
After all...she's been in daycare since she was 8 weeks old...
yes...that is 2 MONTHS!
Thank you Marine Corps...
cause if I would have waited any longer to put her in daycare, I don't think I would have been able to emotionally.
Nick comes home on Saturday afternoon.
Until then...it's just the two of us :-)
Today, after work, I didn't go to the gym.
(normally, I pick her up from daycare, go straight to the gym, put her in gym daycare, and we are home by 7)
I felt like playing outside with her (even though she gets PLENTY of outside time in daycare).
She had so much fun just running around outside :-)
These are the days I live for...
|"Come one mooooom...enough with the pictures, please!"

subset: commoncrawl


text:
Ministry Prosecutes over Medicines Act Breaches
9 Feburary 2006
Ministry of Health Prosecutes over Medicines Act Breaches
Three companies and two individuals have been found guilty of breaching the Medicines Act and Regulations in the selling of medicines to overseas retail purchasers over the internet and in the advertising of the medicines over the internet.
Medsafe's team leader of compliance Derek Fitzgerald has welcomed the judgement of Judge Neil MacLean, released today. The decision follows a defended hearing held over 10 days in the Hamilton District Court in October and November last year.
Derek Fitzgerald says that it is important that the public safety provisions in the Medicines Act and Regulations are met.
All 111 charges laid against three Hamilton-based companies - Ink Media Ltd, Ink Electronic Media Ltd and Standard 304 Ltd and the companies' directors, father and son Wallace Leslie Waugh and Ian Wallace Waugh, were found proven by the court.
Ian Wallace Waugh was absent overseas during the proceedings and is expected to face a further 17 charges upon his return to New Zealand.
The proven charges include selling a prescription medicine without a prescription, selling medicines by wholesale transaction without holding a wholesale licence, selling unregistered medicines, unlawful possession of medicines and breaching advertising restrictions.
The company had advertised medicines without providing legally required information including potential adverse effects, warnings, precautions and notification of the classification of the medicine.
The Court heard from over thirty prosecution witnesses, most of whom were required to attend for cross-examination. The Court found that Ian Waugh and Wallace Waugh had decided that they would change an already established operation to supply medicines to persons overseas. Through Ink Electronic Media Limited and Ink Media Limited and using a Fijian company, the defendants caused medicines, including prescription and restricted medicines, to be supplied to overseas consumers.
An elaborate, complex and inter-connected network of websites was established into which a substantial and regularly updated flow of information by way of advertising and other information was loaded onto websites at the direction of the defendants.
Arrangements for obtaining medicines through New Zealand wholesalers was organised from the defendants' Hamilton premises and then arrangements made for supply of the medicines to the Fijian company. The Hamilton offices also supplied packaging and ancillary equipment to the Fijian company, which was essentially a warehousing and dispatching facility.
A substantial proportion of the sale proceeds came into the bank accounts of the defendants. In the period from November 2001 to August 2003 the whole enterprise had a turnover of over $10 million.
The Court heard of the dangers of selling prescription medication without the individual being under the care of a doctor who had assessed the patient's condition and made an appropriate prescribing decision. Also, the importance of the system of licensing of wholesalers and manufacturers of medicines and the risks associated with a lack of a record-keeping trail if there are recall issues.
Two instances of the dangers of selling prescription medicines without a prescription, highlighted in court, were the sale of anti-depressant Amitriptyline, which if taken in excess can be fatal and the prostate treatment Proscar and hair treatment Propecia, which contain finisteride which has the potential to cause foetal abnormalities in pregnant woman.
Medsafe's Derek Fitzgerald says the aim of the Medicines Act is to ensure that consumers receive medicines that are safe, effective and of acceptable quality.
"Internet sales of prescription medicines place patients at unacceptable risk, because no professional diagnosis is required prior to the purchase of medicines for serious conditions", says Mr Fitzgerald.
"Certain medicines may not be appropriate for particular patients. The patient may be allergic to the product, side effects may result in further health issues or the product may interact with other medications the patient may be taking".
Ink Media Ltd, Ink Electronic Media Ltd, Standard 304 Ltd and Wallace Leslie Waugh will be sentenced in the Hamilton District Court on April 28th.


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Etobicoke (Ontario, Canada) SELLER MANAGED Downsizing Online Auction - Yarn Rd
A max bid would make it more difficult for others to outbid you.
A max bid is the highest amount you are willing to pay for an auction item.
In response to other bids, the auction system will automatically increase your bid in the smallest increment possible (up to your max bid amount) in order to maintain your lead position.
To get a max bid you simply enter the maximum amount you are willing to pay into the bid form just as you would any other bid. If your bid is more than one bidding increment above the current high bid you will get a max bid unless another bidder has a max bid in place that is higher than the amount you enter.
At the end of the auction, the winning bidder pays only the lowest winning bid possible. That means that you can win an auction item at a price less than your max bid amount.
Your max bid amount is kept confidential from other bidders.
You can lower or delete a max bid by entering a lower amount.
Note: After watching hundreds of auctions and talking to thousands of bidders, we think using max bids in your bidding strategy works best for most people. It eliminates some of the pressure and reduces the risk of "sniping", where other bidders slip in slightly higher bids in the last seconds of bidding.
You now have a max bid.
You can raise or lower your max bid at any time by entering a new amount.
If you wish to remove your max bid you can do so by entering an amount equal to the current bid into the bid form.
You can adjust this max bid by using the form above.
If you want to remove your max bid click here.
You can enter the minimum bid of %s or a greater amount.
If you bid more than the minimum bid you will get a max bid that the system will use to bid for you against other bidders, up to the amount you enter. So if you enter a bid of %s for this item, the system will place bids on your behalf in response to bids from other users until someone bids more than %s.
Includes calendar frame
Danby. 19x20x27. Working condition. Note wear
Includes air cleaner. Working condition.
Routers, cabinets for small screws etc. and more
Includes several covered Corning casseroles and other bowls, pie plates, extra lids
Working, with key
33 tall. Note: wear
Drawers wobbly. Note wear. 58x17x30 plus mirror. Note: buyer to bring tools for disassembly.
Gift plate, covered cheese server, flat fold colander, fondue for two and more.
24x29x38. Note: slats in drawers.
Shovels, rakes, trimmers untested
Electric. Untested. Includes cord and cord reels.
Several Lagostina. Note: wear
Wireless back up camera system, Mr. Clean tool
Includes contents of some sort of slides in wood frames.
Four. 17x16x32
Hang on wall. Battery operated. Untested
Includes items on and under 2 tables plus 2 drawers as shown in photos. Tables not included.
5 ft 2 in x 7 ft 6 in
Half moon table, 27x14x30, small square table, 18x18x15
Baskets for closet storage units, each measures 17x21, plastic bins, wicker baskets, tins. Note: wear
Record player untested. Stand 23x15x32.
Telephone table, 28x14x27. Stool, 16x16x14
Hamper, quilt rack, long mirror
Bedpan and oil lamp. Extra glass
Stool 24 h. Stair 22 h.
36" x 26" when sides folded down. 52" when sides are up. Two leaves add 9 in more each. Note wear
Homedics Foot Bath, Brookstone jewelry cleaner, as new with instruction book. Jewelry, watch and more
Chair 29x32x32, side table 14x13x29, stool. Note: wear. Chair matches Lot 224
Florals, Wade miniatures, wood carvings and much more
All untested
Working condition.
Two chairs, 17x16x33
Includes Royal Worcester cake plate, as new in box.
Some new
Circular saws, sander and more. Untested
2 laundry baskets, tp, plastic dish pans
Tools, light bulbs, floor register, flashlights, and more.
White sewing machine plus various sewing items. Untested.
The Genius Inverter. 20w 15d 12h NOT as shown- no photo available, stock microwave photo used.
2 drawers plus hanging rack and crock of extras
On wheels. Working condition.
Includes vintage train case and matching suitcase. Also, bags in several sizes
For tea, cookies, baking items
Salad bowls, serving dishes, candle holders and other serving pieces.
Mainly Bossons England. Includes Jock, Life boatman, and more. Note: chips
Royal Albert, Royal Stuart, Royal Grafton, Royal Kendal
Seven chairs plus folding stool and IKEA lantern
Plate rack, wooden duck, vases
Candles and holders. Table is included if wanted.
Three. Largest 39 x 29
Shredder, office supplies. Touch tone and rotary dial phones, file case and more.
2 wood, 1 metal. 52, 78, and 78 h.
Matches Lot 220. 77x32. Note: wear
Black and Decker bread maker, Moulinex food processer, blender, Osterizer, DustBuster, Crockpot as new.
Corelle dishes, tea pot, French press
Garden items, wind chimes, plastic table cloths and dishes, butane stove, disposable grill, electric burner, new BBQ tools
3 paintings and 2 framed Rockwell prints
Includes step stool, scale and more
Various shapes and sizes. Note wear.
Glass, ceramic. Silk flowers. Glass frog
Table 38x55. Note wear. Umbrella, adjustable chairs with ottomans
Wrapping, small wreath and tree, reindeer
Includes shelves and contents of 2 drawers.
Side table 19x19x30. Includes stool and midcentury TV tables. Note: wear.
Wheel barrel, Note: tire flat. Garden tools, planters, containers.
Platters, small dishes, cream and sugar. Note: wear, tarnished
Various sizes
Floral spread with shams, duster and pillows. White quilt. Drapes, decor pillows and more
Includes tapes, cassettes, CDs and DVDs. Electronics untested. Table is included if wanted.
New Revlon manicure system, vanity mirror, curling irons, jewelry
A bit wobbly. Note: items on top not included.
Many boxes new in wrapping
Secretary chair on casters, swivels.
Tea towels, napkins, placemats, trays, cookbooks, ceramic pots
Cookbooks, history, bios. Includes magazine rack and bookends. Norman Rockwell's America. Note: table not included.
Folding stools. See photo
Stuffed animals, cribbage, jigsaw puzzles, and more.
Mason jars, retro condiment server, serving trays
Solid wood. Note wear
Measuring cups, pans, bowls and more
Floor lamp, table lamps, shades. Lamps untested
Four wood cabinet clocks, Note: partially made.
Rocker, Note: wear, 29x30x31. Table top cement, not secured on base. 16d x 22h
Wine, tumblers, dessert servers, and more.
Sklar Peppler chair, 36x36x36. Matches Lot 277
Sklar Peppler sofa, 80x36x36. Matches Lot 276
Double size, 57x38 and 57x28. Do not match.


text:
Ratings based on 90 Verified Reviews
4.6 Room cleanliness
4.6 Service & staff
4.6 Room comfort
4.6 Hotel condition
Expedia Verified Reviews
for Everyoneby A verified traveler from Dallas, TX
Honeymoon Dream LandPosted May 8, 2017
This was our first time coming to Thailand and we made the right decision coming to Phuket and staying at the Naka Island Resort. The resort truly made our honeymoon experience wonderful. Everything we needed was taken care of and then some. The staff was incredibly accommodating and friendly. It was so easy to book trips off the island! Along with hotel expeditions, they had an onsite travel company ready to book any and all adventures! The food was wonderful and exceeded out expectations. The Naka Island is truly a wonderful and magical place.
for Everyoneby A verified traveler from Tokyo
Stunning property with excellent friendly servicePosted May 5, 2017
A stunning beachfront hotel with private villas each with a private pool. Unlike other resorts, what made the experience so special was the friendly and competent staff. Great getaway spot.
for Everyoneby A verified traveler from Singapore
The complete packagePosted Apr 14, 2017
We stayed for 6 nights in a seavire villa. The villas are large and have beautiful views of the sea. The grounds ante spacious and lush and the villas are discreet and blend into the scenery with style. This is a place to relax. It is understated luxury and discrete service at its best. The staff are what make this please special. We were very well looked after by the restaurant staff who handled our daughter's gluten allergy very well. A special mention must go to Daniele, Sky and Pom in the restaurant who were incredibly helpful and attentive (nothing was too much trouble!). Special thanks also to Rose and Ya and the front desk team who met all our requests with a smile. Very easy and accessible place with a private boat to take you to the jetty and golf carts to whiz you round the resort should you not feel like walking round the beautiful grounds. Spa also excellent. Very easy and relaxing holiday. Hope to be back!
for Everyoneby A verified traveler from Kuala Lumpur
Phuket's TreasurePosted Apr 5, 2017
Pros: Everything.
Cons: They should look into doing massages by the beach. Especially foot massages and back massages.
This resort is a real treasure. It is splendid in every sense of the word. The resort is beautiful, it is luxurious, quiet and relaxing - the perfect place to destress. The staff are helpful and always smiling. The food is great. The spa is amazing ... but I only wish I booked my slots in advance because it was quite booked up. I would definitely recommend this resort to friends and will make a trip back soon. I would suggest the sea view villa for privacy. The only thing to note is that it is not a place for those who want to enjoy Phuket's nightlife or even Phuket town - for that you should stay in Phuket.
by A verified traveler
Posted Dec 11, 2016 on Hotels
We thoroughly enjoyed our honeymoon here and found the whole resort, rooms and facilities to be very good. The only real negative was the cost of food and drinks on the island given you can't leave and if you do its costs 800Bht to do so (what a joke of a cost to leave the island!). The resort was large (around 60ish rooms) but well layed out and resorts were nicely spaced. Most seemed private but some were open to the pathways etc but it was generally very quiet so there was still a good level of privacy. The pools were really nice and next to the beach which was also nice for a dip depending on the time of day (the tide went out in the afternoon making it tricky to swim in the sea then - so we went in the pool then). The staff were very kind as well with drinks, towels and even free ice cream when next to the pool. The spa was excellent - it was highly priced however they had some 'deals' on which brought the cost down to somewhere closer to reasonable but it was worth the extra costs. The restaurants were ok - service was quite poor (they got our order wrong on 3/4 occasions during our staff) and quality was ok but very poor for the price you were paying (essentially good thai food but at very high western prices). The bar was very nice and had a lovely setting to see the sunset. The prices again were ridiculous but they did have buy one get one free between 8-9 which was good but then everyone left at 9.01pm.
by A verified traveler
Flawless.Posted Sep 16, 2016 on Hotels
An absolutely amazing hotel on an absolutely amazing island. I can't recommend this hotel enough. Thoroughly enjoyed every part of the stay. Flawless and perfect in every way.
for Everyoneby A verified traveler from Miami, FL
Gorgeousssssss!!!Posted May 18, 2016
Pros: The location, pool area, free homemade ice cream, beautiful grounds, gorgeous room.
Cons: The food in the restaurant and the buffet could be improved greatly. Obviously it is difficult to dine anywhere else as you are on a small island.
Location: It seems pretty secluded on this island which is great. You can kayak, jetski, bike and go to the spa.
Incredible experience. In order to get to the resort you have to take a speedboat from a nearby marina. It takes less than 5 minutes to arrive at Naka Island. You then arrive on the beautiful elongated dock where it has some of the most stunning views ever. You are immediately greeted as soon as you step foot off the boat by a staff member that then personally drives you via golf cart to your private villa. The staff member then gives you a tour of the villa and checks you in while there. The villas are ridiculously beautiful. So relaxing and so quiet. You listen to the birds singing all day. The bed was extremely comfortable as well. The pool area is impressive and the beach is also very stunning. I would highly highly recommend this place if visiting Phuket.
for Couplesby A verified traveler
Great hotel with fantastic staffPosted May 1, 2016
Pros: Privacy and staff
Ocean View Pool Villa's are very private and worth the extra amount
by Imran from Dubai
Simply fantastic!Posted Apr 19, 2016 on Hotels
I have been very fortunate to stay at some fantastic five star hotels and resorts but this is quite simply the best hotel I have ever stayed at. The private villa was great, the food was high quality, and any place that gives out free home made coconut ice cream every day by the pool is definitely doing something right! Definitely somewhere I would love to come back to and stay again.
by Chris from London, UK
Great stay at NakaPosted Jan 28, 2016 on Hotels
Overall my family including my wife and 7 month old son stayed here for 5 nights. It was great having the private pool to take him swimming. The restaurants and bar was also very good with great service. The only negative would be the local beach at the hotel which was merky, shallow, and could have used some more beach combing. We would stay here again.


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ProductivityOctober 12th, 2016 by Macworld Australia Staff
Dropbox for iOS gets new business features
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Apple is on track to release new iPads next year, which isn't a big surprise. What is intriguing, however, is the rumoured sizing of those new iPads:...
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I'd like to start with a brief test. All those who have more than one Apple ID, please raise your hands. Now look around you; if you're in a group...
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In the wake of an FBI investigation, Apple mounted a high-profile campaign on behalf of its users' privacy. But it turns out our privacy is still...
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text:
Guidance and Support Regarding Quicken Features @ ...
Category : Internet Posted : 21/09/2016 Price : Free Location : New York City(New York)
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South Piedmont Community College transportation engineering
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Find info concerning South Piedmont Community College transportation engineering, and registering in a elective technical programs. Which college degrees give you the best chances of finding employment after graduation? Are you are considering an associates degree in electronics engineering, or a bachelor of science in mechanical or civil engineering? Concentrating on South Piedmont Community College transportation engineering, for example, you may gain an advantage in job recruiting on-campus. Check with the civil engineering department for course registration deadlines, and highway engineering program requirements. Please use the form above to request admissions info for South Piedmont Community College.
Civil engineering programs typically take three to five years, and courses include physics, math, project management, and specific topics in civil engineering. Materials science is closely related to civil engineering, and deals with industrial mixtures such as asphalt concrete, strong metals like aluminum and steel, and novel polymers including carbon fiber. Civil engineering technicians assist civil engineers in the development of industrial and municipal infrastructure projects. The annual wage of civil engineers with a bachelors degree averaged $82,220 in 2017, while civil engineering technicians with an associates degree earned roughly $52,300 per year.
The subdiscipline of structural engineering governs construction of buildings, bridges, tunnels, and off-shore structures. This involves identifying the loads which act upon a structure, and the forces and stresses which arise within that structure due to external stresses. How can the structure successfully support and resist those loads? The structural engineer takes into account both material considerations such as strength, stiffness, and stability of the structure, as well as other design considerations including cost, safety and sustainability. Due to the nature of some loading conditions, wind engineering and earthquake engineering have developed as specialties within structural engineering. Beyond major requirements within the civil engineering department, you may consider St Francis College digital logic design as an adjunct to your primary course of study.
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I am the essence of uncool. I drive a 2000 Mitsubishi with dents as big as Shaq's shoe and a booster seat in the back that weighs more than my five year old. The parties I attend usually break up around 9 p.m. (when the babysitter gets very expensive). I don't blog.
Now, I know some will contend my column often leans to the self-indulgence of a big, fat blog, but I'll ignore those sentiments for the moment. The reason I don't blog is because I find most blog writing a waste of precious time. Frankly, most bloggers have very little to say. Consider the Doonesbury character who simply must have a blog but can't conjure up the content. Instead, he copies op-ed columns from The New York Times and peppers them with innovative punctuation.
I've carried the torch for decent content ever since the folks at ClickZ gave me the amazing opportunity to write a column. I can't stop now. Honestly, did you really think I would cheer on those rambling bloggers who bore us with everything from their political tirades to the dreary lives of their Abyssinian cats? Of course not. If I wanted to read about cats, I'd pick up a copy of Cat Fancy (something I've never done).
However (and this is a big however), I don't think we should toss aside the possibilities of the medium. Blogs have an immediacy and ease of use that may justify using them on a business' site. For example, a simple note on a blog may get the word out on an important, but not necessarily press-release-worthy, news item. Having a blog on a site does compel the organization to refresh the information more frequently.
Macromedia is a good example of how blogging can be used in business. The software company employs a blog to keep customers updated on what's happening with its products.
Another interesting technique is to post both good and bad news on the blog. By not avoiding the bad, the organization can also post its quick remedying of the situation. When done honestly and expertly, such an immediate response may help build confidence in the company.
Blogs may also rescue marketing communications staffers from waiting for overworked techies to manipulate HTML code before posting a simple message. When the message has to be up quickly, nothing beats the blog's ease of use.
And there are valid reasons for using blogs for internal communications. Read the online edition of Blogroots by Paul Bausch, Matthew Haughey, and Meg Hourihan for some thought-provoking ideas on bringing blogs into the workplace. The authors point out that information posted on blogs can be more easily retrieved than the two-week-old email. They also suggest that with a group blog, you can ease bandwidth crunches because large files can be uploaded once to a central location, then announced as available for viewing to interested parties. Additionally, blogs may be useful for establishing rules of the road for corporate culture. And there is the somewhat obvious but worthwhile observation that coworkers who aren't comfortable speaking publicly may find a new way to express themselves through blogging.
We need to be a little more mindful of how we use this interesting new medium. With email succumbing to the denizens of Spam City, we do need quick and easy ways to establish one-to-one relationships with key audiences. I'm hopeful that the narcissistic musings of a few will eventually wane, and we can arrive at better ways to use the blog.
In the meantime, I'm told the latest killer app is no longer the blog, but the
Yeow. My advice? Unless you can commit to posting interesting, meaningful content, don't let your site go to the blogs (or the cats).
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As technology leaps and bounds head, trying to develop bespoke content for each new channel can be a headache for content marketers. However, what if there was a way to 'future-proof' your content and seamlessly deploy it across any channel – even ones that don't yet exist?
Facebook goes after clickbait headlines – five tips to maintain reach
Facebook has announced the rollout of three more updates designed to target and eliminate clickbait headlines. Here's how to make sure you aren't affected, and maintain your Page's reach in the midst of the changes.
Why brands should make the leap to podcast advertising
In an exclusive guest post for ClickZ, Stuart Last, COO at audioBoom, explains who is listening to podcasts, what they are buying, and how brands can capitalize on this behavior.


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FragranceX.com coupons
Here you can locate a recap of the updated Fragrancex coupon codes and discount codes avavilable.
Use Fragrancex coupons every time you shop. Just come to our web site, where saving you cash with the best Fragrancex coupon codes and Fragrancex discounts is our goal. When you need online coupon codes, your first stop should always be on our site !
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We have made this Fragrancex coupon codes page, to make your online Fragrancex shopping as enjoyable as possible. You can save big with the current Fragrancex coupons and coupon codes outlined below.


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Principals, teachers and parents are invited to a Gonski event to be held on Monday 31 August at Nepean Creative & Performing Arts High School. The event will commence at 6.30pm.
As we move through only the second year of the Gonski agreement, more and more schools are recognising the positive difference additional Gonski funding is already making to student learning outcomes. At this event, you will hear a number of local Principals and teachers share their Gonski stories.
It will be a great opportunity for all schools to think about how they can develop and share their Gonski stories with their parents and communities. Upholding our aspirations for all students and meeting the learning needs of every child is the priority of the Gonski campaign.


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Day County District Attorney 506 Main Street Webster SD 57274 14.9 miles from 57261 605-345-4624
Marshall County District Attorney PO Box 107 Britton SD 57430 21.0 miles from 57261 605-448-2775
Roberts County District Attorney 414 3rd Avenue East Sisseton SD 57262 23.3 miles from 57261 605-698-7071
Sargent County State Attorney PO Box 125 Forman ND 58032 39.1 miles from 57261 701-724-3888
A district attorney prosecutes cases on behalf of the public. District attorneys manage the prosecutor's office and play a central role in investigating charges, deciding whether to charge someone with a crime, offering plea bargains, and litigating appeals. They also advise parole boards on inmate requests for early release.
District attorneys maintain records on current and former cases. Many of these records are available online and open to the public. This site can help you access the records you need from a district attorney.


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House of Craziness Resource Showcase
If you joined the reborn House of Craziness, you've been invited here. this place is an easy access resource place for the general house of craziness... things, also, this is where major choices in terms of plot are discussed. some competitions will be held for the sake of keeping general interest, feel free to take part, you may enjoy it and the bizarre results you make. CURRENT COMPETITION: None END DATE: N/A
*freshly updated* Seth
March 2nd, 2016, 5:11 am
Author's Comments:
Reply Advertisement, October 18th, 2017, 7:51 am
User's Comments:
Reply WolfryHedgies, March 2nd, 2016, 12:05 pm
At least he has good hair that belongs to him.
Reply WolfryHedgies, March 2nd, 2016, 7:48 pm
@Kitsunah: I would say but it would sound like bashing.
Reply Assassin is Lazy (Guest), March 3rd, 2016, 5:29 am
What is his name? He has to have a name after all. And when will he get to the House of Crazyness?
Reply AssassinPerson, March 3rd, 2016, 4:04 pm
@Kitsunah: He needs a name though! Every other character has a name, even the lesser important ones who will be seen for only a few pages in a plotline. Which I don't think we have any of yet.
Reply WolfryHedgies, March 5th, 2016, 12:52 am
@Kitsunah: Bro that dagger won't even pierce through.
Post A Comment


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Submitting Reference Letters
Selecting Your Referees
Selecting your referees is a big decisions. You will want to choose referees who are able to accurately do an assessment on your strengths and weaknesses pertaining to your ability to conduct graduate studies. This type of referee may need to be an academic referee [Examples are: a faculty member who taught you in a course(s); observed you in a classroom/laboratory setting; supervised you doing an undergraduate thesis, etc.] and/or may need to be a professional referee [Examples are: supervised you in a practicum/placement setting; supervised you in a work setting; a co-worker who has observed your work ethic].
The type of referee required will be noted in the Supporting Documents table. If "academic" or "professional" is noted in brackets after the "Letters of Reference/Assessment Reports" information, it means there is such a requirement.
Listing Your Referees
Once you have submitted your online application you will be directed to the Graduate Admission Application Status page where you will need to supply first and last name as well as an email address for each referee. The email address provided should be the referee's professional or institutional email address; we will not accept emailed references from personal email addresses such as Hotmai or Yahoo. If your referee does not have a professional email address, please refer to "Paper Submission of Reference Letter".
Your referees will automatically be forwarded an email from UNBC providing them with access information for uploading or completing an online reference.
Reference Letter Submission Status
Once the referee uploads their reference letter, or completes their reference online, you will be able to see the date it was submitted in the "Status" column of the Graduate Admission Application Status page. Follow up on your application frequently.
Referees will not receive a reminder notice from UNBC. If it is coming close to the deadlines and you see that a reference is still outstanding, we encourage you to contact and urgently remind the referee of the deadline.
Paper Submission of Reference Letter
Office of the Registrar - Graduate Admissions
3333 University Way
Prince George, British Columbia V2N 4Z9


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The Loach Forum Archives (6)
The wonderful, wonderful foodstone *PIC*
Posted By: Henrik <email@example.com>
Date: Monday, 21 February 2005, at 4:05 p.m.
After some weeks my gastromyzons have gotten used to being fed on this "foodstone". A stone I cover with a paste of gelatine mixed with powdered food. On the picture they allmost finished eating. The food is the green stuff on the rock. The foodstone is a very popular place to go and eat. One or two fish often cling to the stone when I lift it out of the water in order to paste the food onto it. The method involves a bit of extra work of course. But in my tank it's worth it. I believe the algae groth in my tank is insufficiant to feed all of my hillstreams. And food pills are very quickly swallowed by the larger danios and barbs - leaving only little food for the hillstreams. Using the foodstone the hillstreams get their fair share of the daily meal.


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Endeavour Mining Corporation
Endeavour Mining Corporation
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Related Content
West African specialist Endeavour has approved construction to start on the $US412M Ity carbon-in-leach gold project in Cote d'Ivoire after an optimisation study strengthened its production and economic forecasts.
The CIL project is expected to extend the Ity mine's life by 14 years, delivering average production of 235,000oz at AISC of $494/oz over the first 5 years.
President-CEO Sébastien de Montessus says the study clearly positions Ity as Endeavour's next flagship asset.
Avnel Gold Mining shareholders have accepted Endeavour Mining's mutually agreed $US122M ($C159M) all-share bid for the company and its flagship 80%-owned 2Moz reserves Kalana Gold project in Mali.
The deal will see current Avnel shareholders with about 6.8% of Endeavour's pro forma share capital.
West African focussed gold miner Endeavour Mining is selling its 90% stake in the producing Nzema Gold Mine in Ghana to one of Africa's largest mining/civil contractors, Ghana headquartered BCM Int'l, for up to $US65M cash.
Big African contractor BCM is buying Endeavour Mining's 100,000oz+ pa Nzema Gold Mine in Ghana for $65M cash
Canadian gold miner Endeavour Mining is making a mutually agreed $US122M ($C159M) all share takeover bid for Avnel Gold Mining to add its 80%-owned 2Moz reserves Kalana Gold project in Mali to the Endeavour project pipeline.
The boards of both companies have unanimously approved the deal that will give Avnel shareholders about 6.8% of Endeavour.
Endeavour Mining to add new 2Moz reserve Mali gold project to production pipeline with $C160M bid for Avnel Gold Mining
West Africa-focused Canadian gold miner Endeavour Mining and fellow African miner Acacia Mining, majority owned by Barrick Gold, have confirmed they have ended potential merger talks.
Record Dec 2016 year (FY/CY2016) gold production from its 5 producing West African mines up 13% on the previous year to 583,714oz at AISC down 4% to a record low $US884oz, has seen Endeavour Mining lift attributable net earnings 145% to $93M.
And the company is expecting more in FY/CY2017, with production up to 600,000oz-640,000oz group AISC expected to continue to fall to $860oz-905oz.
Record FY/CY2016 gold production and record low costs lifts Endeavour Mining profit 145% to $93M
African-focused gold miners Endeavour and Acacia have confirmed they are in "preliminary discussions" on a possible combination. Both were responding to media speculation of a tie-up.
While Endeavour says its strategic focus remains on organic growth of its existing asset portfolio in Mali, Code d'Ivoire, Ghana and Burkina Faso, Acacia - the former African Barrick Gold - notes that potential combinations are part of its business development strategy.


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What is the nicest thing someone has done for you this week?
Image: Stephanie Nielson
Some very nice soul sent our family some California Pizza Kitchen gift certificates! Thank you!
What's the nicest thing someone's done for you -- or have you done something nice yourself? Tell me -- I want to know!
More from parenting


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Qualities such as a reputation for strength and unique styling are what make your vehicle special , which is probably what makes you love it so much. If you're tired of the high prices from your mechanic, then and are in need of parts to fix your Cadillac. Obviously, Cadillac is known for a reliable name and long-lasting quality. But when something breaks you have to replace it by purchasing Brake Proportioning Valve parts that don't break the bank. When a Brake Proportioning Valve is faulty it can make for an extremely unpleasant experience for any driver.
Who wants to pay dealership prices when we can offer you the exact same auto parts for your Cadillac at a discount online? Driving a vehicle known for its dependability means you shouldn't trust it to the cheapest parts you can find. Since you can now buy great replacement Brake Proportioning Valve parts for your Cadillac online, you can now buy everything you need from an authoritative website like www.carpartsdiscount.com rather than from your local dealer. To find the correct Brake Proportioning Valve parts for Cadillac 60 Special, Commercial Chassis, DeVille, Eldorado, Escalade, Fleetwood, Seville and more, simply click your model from the list below.


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Peter Barlow is an experimental musician from Livonia, Michigan. His debut album, Songs for Kelsey, is available to stream and download for free at http://peterbarlow.bandcamp.com/
Here is currently working on his second album, Studies in Density and Chance.
Artist descriptions on Last.fm are editable by everyone. Feel free to contribute!
All user-contributed text on this page is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply.


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Nicely built 4 bedroom semi detached house in a gated community in Idado. Property is beautifully built and well finished with interlocked tiles, nice built in cupboards, well ventilated rooms all ensuite. Very few units left
Just fill in the details below and we'll send your friend an e-mail with information and thumbnails of this property


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Returning to Running?
Welcome back!
If life were a Hollywood movie, a running comeback would play out something like this – you'd struggle for a bit, get beaten by the bad guys in a few races, consider giving up, but then, against all the odds, everything clicks and you return to former glory and win.
Well, we have some good news for you. With careful scripting such a role is available to you, the runner who used to put in the miles in school and perhaps beyond, but for the last decade or so has enjoyed a slightly more sedentary existence. It may not seem possible as you stop exhausted after a couple of hundred metres on your first run this century, but science and physiology has just one message for you – it is possible to get back. Things will definitely get better. A Hollywood role as the good guy returning to beat everyone is possible.
"If you've been a reasonably good runner that usually says you have the physiological capacity to run," says John Brewer, sports professor at St Mary's in London (and a not bad runner). "If you stop that genetic capacity doesn't just go away. It may get hidden by layers of body fat and a decline in cardiovascular capacity, but it is still there."
Needless to say that doesn't mean you that on day one of your resolution to get back to fitness you head out of the door and attempt to relive the exploits of your youth. You body and its higher fat content, combined with a reduced ability to process oxygen as well as a teenager and tighter muscles and degenerating tendons will tell you straight away that was a foolish move.
"You need to understand your body will not respond how it used to," says sports scientist Dr Sarah Rowell, who ran a UK record for the marathon of 2:28:06 back in 1985. Put simply, you will take longer to recover because of hormonal depletion and damage running does to muscle fibres or connective tissues. However, she's keen to point out that once you've been checked by a GP to make sure there are no underlying problems, there is no reason physiologically why with time you cannot return to a good training level.
There is no excuse
Every runner will have heard the line ' I used to run, but my knees can't take it any more.' And while that may indeed be true for some unfortunate athletes out there, be assured, running is actually good for you. For most of us, that's not a valid reason to don our shoes once again. "All the evidence says that," confirms John Brewer. "And it doesn't cause damage," he adds. That's an interesting point. Marathon great Bill Rodgers (2:09:27 in 1979) recently quoted cellular damage as one of the reasons he doesn't compete so well in age-group. "No research behind it," Sarah Rowell says flatly, while John is of the same opinion. "When it does occur, it repairs very quickly," he says. And actually Bill himself should use a different line for his declining speed as the stats tell us he could break 70min for the half marathon aged 50!
More likely reasons for decline – aging aside – include training regimes followed, diet, lifestyle and motivation. "Inevitably there is a physiological decline – speed and power mostly. You just cannot produce the same you once did. You cannot stop that decline, but you can slow it down," says John.
Strength training is something that will do exactly that. Runners (of yesteryear and currently) are notorious for just going out for a run and leaving it at that. "A focused gym-type programme is important," says Sarah. Research tells us that men who lift weights a few times a week in their 50s and 60s can maintain their muscle mass, not simply slow the rate of decline. No more excuses, get strength training.
Sarah also has some valid opinions on short, sharp speed work, again something 'runners' tend to ignore. "As you get older, tendons do not respond as well, so sprint-type work can 'regenerate' (slow their decline) them."
Of course, it goes without saying all this hugely personal. Sarah readily admits that 2:28 is obviously beyond her now, but so is the training required to produce an age-group time on a par. Her biomechanics have changed as years of sitting behind a desk has shortened muscles. Indeed the latest research suggests sitting passively all day long at work is nearly as bad as smoking. Motivation has also gone. "Could be there are some inbuilt receptors that tell you to slow down because of the pain you could inflict on yourself when you were younger," she speculates, quoting Tim Noakes, a world leading authority on the physiology of running.
Or you're just a bit wiser. But don't ever use the excuse 'it's too late' because it isn't.
Science has changed
If you've been away from running for a while, science has much to tell you. Runners of a certain vintage didn't drink, or use energy gels; there's a big change there. Equally the understanding of how effective short, sharp speedwork can be, even for older runners, has changed. The science behind running shoes has altered dramatically as well. And make sure you know what you're looking for when it come to breathable fabrics – they really do make a difference. Don't forget stretching. Used to be that was good, but not any more. Dynamic movement before a run is great, static (old fashioned) stretching good afterwards.
You will get beaten
Chances are, if you're returning, you're a little older and well, younger runners will beat you – physiological fact. Runners who don't look like runners will skip away into the distance. Worry not, you'll still beat many, find your own level.
It's not wrong to rest
Understand the importance of recovery and you'll reap the benefits. It is possible to do the same kind of training you used to but when you return to running, you must realise you have to take longer between races, long runs, short runs… heck everything…. to allow your body to repair. Forget the 'no pain, no gain' mantra and get your feet up.
You probably like a beer or two
Lifestyle is hugely important and clearly alcohol may play a role in this. Do you have a mortgage, kids, an important job? These all play a role in your life, more so than when you gave up running (to get married etc). But don't feel bad; have a beer and reassess your goals.
You're no longer 18
Sessions that you could do on a whim will cause damage; muscles have shortened, tendons have become less pliable. They can still work, but with time and care. And as for your heart, well put simply, it will not beat as fast as it did when younger due to a steady fall in the number of receptors in your heart to tell it do so.
Forget those sausage rolls
A controversial area that has a simple (and complex) result; lose weight and you will run quicker. Indeed 1lb lighter is roughly 2sec per mile quicker on a long run. Of course, starving yourself is not the key and nor possibly is shedding pounds. But if you do want to run quickly again, you're going to have to do something about it from a diet point of view.
Paul Larkins, author of this piece and sub four-minute miler in the late 1980s has his own come-back experience...
Ever the willing guinea pig, Paul embarked on, not a return to running, but a return to training. Days (and years) of easy 30min runs were replaced by a move back to world of fast mile repetitions, long runs and even racing. Initially, things were tough and racing was, at best, moderate. But given time (12 weeks in this case), the change, while not strewn with world records, was very encouraging. Times dropped, run length increased all the way to 20 miles and race pace dropped to below 6min per mile for shorter events (5km).
The secret? Forget what you've done training-wise in the past and come at from a new angle. Still train hard, but don't be afraid to take a day or three off. And above all, enjoy it!


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Finding support
Having support and community resources can help increase your confidence in managing Bohring-Opitz-Syndrome (BOS), enhance quality of life, and assist in meeting the needs of other family members. Parenting is often challenging, and parenting a child with a chronic condition like BOS can add additional stress to the day-to-day challenges. If you are the parent or caregiver of a child with BOS, it might be helpful to talk with other parents who have a child with the same condition in our "Bohring-Opitz Support Group".
Finding each other
Bohring-Opitz Syndrome is an ultra rare syndrome with worldwide less than 60 people diagnosed in medical articles. Of course much more children have been diagnosed with BOS by genetic testing in the recent years and we are a growing family. The "Map Children with BOS" in addition to our "Bohring-Opitz Support Group", is an opportunity to find each other and maybe – one day that comes from meeting face-to-face.
Family stories
These family stories are from families around the world whose children have been affected by Bohring-Opitz Syndrome. They are stories about partnering with doctors, finding helpful resources, and seeking answers… but mostly they are stories of persistence and strength and hope. We thank the families who have so generously shared their Family Stories. with us.
Our children have been fighting bravely in their sometimes far too short life here on earth. With love and care we cherished them. And that will not end – even after they are angels now. We want death not to be a taboo. All these children together with their families have a meaning, they are valuable and not forgotten. So this page, the "Memory Lane BOS Angels" is dedicated to our BOS Angels where we all can let parents, families and friends of BOS Angels know that their precious child did not fight for nothing in their lives, that we did not forget them and they will always stay in our hearts.
Would you like to share your own experience (also in your own language)? Please contact us at email@example.com.


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Reading through the addendum to Sen. Bob Corker's financial disclosure, you might think the Tennessee Republican had been seriously misreporting assets and income.
But the reality might more underscore the shortfalls of the system.
Corker retained a CPA to review his financial disclosures. (Al Drago/CQ Roll Call File Photo)
Reading through the addendum to Sen. Bob Corker's financial disclosure, you might think the Tennessee Republican had been seriously misreporting assets and income.
But the reality might more underscore the shortfalls of the system.
(Bill Clark/CQ Roll Call)
The Senate Foreign Relations Committee wants to hear directly from Secretary of State John Kerry about the situation in Syria, as Russia has begun to conduct airstrikes.
Foreign Relations Chairman Bob Corker is inviting Kerry to testify next week, though the State Department has not confirmed he will appear before the committee he chaired as a senator from Massachusetts. "The Senate Foreign Relations Committee has requested Secretary of State John Kerry testify next week to explain the administration's Syria strategy to Congress and the American people," the Tennessee Republican said in a statement. "Until we are prepared to take steps to address the root cause of this crisis — the Assad regime — we will continue to see dangerous consequences in the region that will impact our allies and our security interests."
Chinese President Xi Jinping, center, flanked from left by House Minority Leader Nancy Pelosi, Sen. Dan Sullivan, Senate Majority Leader Mitch McConnell, Sen. Maria Cantwell and Sen. Mazie Hirono pose for photographers before their meeting Friday. (Bill Clark/CQ Roll Call)
China's President Xi Jinping on Friday tried to assuage concerns from the two top Senate Foreign Relations Committee members over cyberthreats and actions in the South China Sea.
Senate Foreign Relations Chairman Bob Corker, R-Tenn., told CQ Roll Call that Xi, in a meeting with a bipartisan group of lawmakers, responded to Corker's concerns by saying "the kinds of things you expect to be said," on "these types of trips."
Corker, left, and Cardin met Thursday with State Department officials and the full Foreign Relations Committee. (Tom Williams/CQ Roll Call File Photo)
The State Department still has some explaining to do after a closed briefing Thursday with Senate Foreign Relations Committee members over allegations that a report vital to several administration initiatives was watered down for political purposes.
Committee members have cried politics since July when the annual Trafficking in Persons report was released. After Thursday's briefing, senators called for more transparency in the process that saw Malaysia and Cuba upgraded from the lowest ranking in terms of human-trafficking conditions. "My concerns were not alleviated in any way," Chairman Bob Corker, R-Tenn., said. "I don't think there is anybody who was there that didn't feel even more firmly that politics played a major role in determining some of the upgrades in the TIP report."
Corker and Cardin are two of the relevant committee leaders opposed to the Iran deal. (Tom Williams/CQ Roll Call File Photo)
Senate Foreign Relations Chairman Bob Corker made an interesting point on Sept. 4 : The two Democrats who have spent the most time studying the issues surrounding Iran are against the deal.
The Tennessee Republican was applauding ranking member Benjamin L. Cardin's opposition to the Iran nuclear deal; the news of which broke at the end of last week. Corker also opposes the deal, like every other Senate Republican with the exception of Susan Collins of Maine, who hasn't announced a position yet. "The fact that the two Democrats who have spent the most time in understanding the details and impact of this deal do not support it speaks volumes," Corker said in a statement.
Cardin and Bennet are proposing a bill aimed at strengthening the Iran deal. (Al Drago/CQ Roll Call File Photo)
While Democratic Sens. Benjamin L. Cardin and Michael Bennet announced opposite positions on the Iran deal Friday, they were united in their support for legislation they'll introduce to strengthen it.
Cardin, ranking member on the Foreign Relations Committee, announced his opposition to the deal in an op-ed , while Bennet backed the deal in a statement to The Denver Post. But the deal itself is already a fait accompli given that the White House has already lined up enough support to sustain a veto of a disapproval resolution, and that has Cardin of Maryland and Bennet of Colorado looking ahead.
Corker says there will be more legislation after the Iran disapproval vote. (Al Drago/CQ Roll Call File Photo)
Senate Foreign Relations Chairman Bob Corker is home in Tennessee, but he said Wednesday he's been on the phone a lot about Iran — particularly with moderate Democrats.
The Republican said his role is to answer questions and foster debate, while making the case against the P 5+1 agreement to restrict the Islamic republic's nuclear program. But, with the number of Democratic caucus members backing the Iran deal at 29 and expected to increase, Corker's also looking ahead to other legislation in response.
As expected, Corker and Menendez are both opposing the Iran deal. (Bill Clark/CQ Roll Call File Photo)
Sen. Robert Menendez surprised no one Tuesday when he became the second Democratic senator to oppose the Iran deal, but the momentum is clearly in favor of the deal among Democrats.
"Unlike President Obama's characterization of those who have raised serious questions about the agreement, or who have opposed it, I did not vote for the war in Iraq, I opposed it, unlike the vice president and the secretary of State, who both supported it," the New Jersey Democrat said. "My vote against the Iraq war was unpopular at the time, but it was one of the best decisions I have ever made."
Corker and Cardin prepare for a committee hearing on the Iran nuclear deal on Tuesday. (Tom Williams/CQ Roll Call File Photo)
Testimony from a State Department official Thursday did little to dispel claims that an annual human-trafficking report was driven by politics.
State Department Undersecretary Sarah Sewall defended the integrity of the report, which upgraded the status of Malaysia and Cuba, to three members of the Senate Foreign Relations Committee by citing the report's criteria, Secretary of State John Kerry's public comments, and her own assessment — but occasionally declined to comment on internal deliberations. The committee was unconvinced.


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Dalat Hasfarm is a pioneering floricultural company in Vietnam. Established in 1994, Dalat Hasfarm aims at applying high tech, sustainable, and innovative varieties for its large and fast growing markets in Vietnam. We are active in multi channels such as wholesales, mass retails, retail flowers shops as well as online sales.
We have experienced the fast growth in Vietnam, and need excellent marketing campaigns and initiatives to further develop our market share. We are looking for a bright and energetic TRADE MARKETING MANAGER with solid marketing experience to develop flowers and plants marketing plans in Vietnam.
POSITION: Trade Marketing Manager
WORKING PLACE: 266-268 Nguyen Thien Thuat Street, Ward 3, Ho Chi Minh City.
SALARY: Salary will be in line with experience and qualifications.
If you are interested, please send your application to the following email address:
Deadline for receiving Job Application: 15/10/2017


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Dolce & GabbanaGrey Metallic Silk Tiered Bodycon Spaghetti Strap Dress
Dress has exposed back zipper closure. Printed, tiered front. Adjustable straps. Size: 40
Made in: Tunisia Color: Grey and Black Fabric Content: 85% Silk, 12% Polyamide, 3% Elastane. Lining: 60% Polyester, 37% Polyamide, 3% Elastane. Condition: Good. Faint markings. Several loose threads.
Measurements & Sizing
- Bust: 29"
- Waist: 25"
- Hips: 31"
- Total Length: 37.5"
Returns & Shipping
Luxury Garage Sale guarantees that all items sold on our site are 100% authentic. All products we accept are inspected for brand-specific guidelines and are put through a rigorous authenticity test process.
LGS is not affiliated with Dolce & Gabbana. We guarantee this Dolce & Gabbana item to be authentic. Dolce & Gabbana® is a registered trademark of Dolce & Gabbana.
Item #: 97656


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Glucocorticosteroids such as dexamethasone (Dex) increase sugar and lipid uptake in adult animals and accelerate the development of the immature intestine. The effect of Dex on the ontogeny of lipid absorption is unknown. In adult rats, glucagon-like peptide-2 (GLP-2) has a trophic effect on the intestine and enhances nutrient absorption. This study was undertaken to determine the effect of GLP-2 and Dex on the intestine uptake of lipids in suckling rats and to determine whether any such effect persists into the postweanling period. Sixty-four suckling rats were randomized into four groups. They were treated from days 11 to 21 with GLP-2 (0.1 μg·g−1·day−1 sc), Dex (0.128 μg·g−1·day−1 sc), GLP-2 plus Dex (GLP-2 0.1 μg·g−1·day−1 sc + Dex 0.128 μg·g−1·day−1 sc), or placebo. One-half the pups were killed at days 19–21 ("sucklings"), and one-half were killed 4 wk later ("weanlings"). The rate of intestinal uptake of six fatty acids (12:0, lauric; 16:0, palmitic; 18:0, stearic; 18:1, oleic; 18:2, linoleic; and 18:3, linolenic) and cholesterol was assessed using an in vitro ring technique. GLP-2 had no effect on lipid uptake. Dex increased the uptake of 18:3 in sucklings, and the ileal uptake of 18:0 was increased in weanlings. The combination of GLP-2 plus Dex had no effect in sucklings and increased the ileal uptake of 12:0, 18:0, 18:1, 18:2, and 18:3 in weanlings. The enhanced uptake of fatty acids with GLP-2 plus Dex was not explained by alterations in the animals' body or intestinal weights, intestinal morphology, or intestinal- or liver-fatty acid binding proteins. Unlike adults, GLP-2 does not enhance lipid uptake in sucklings. Dex has a modest enhancing effect on selected fatty acid uptake both in sucklings as well as weanlings. GLP-2 plus Dex has an enhancing effect on the ileal uptake of fatty acids in weanlings 4 wk after their previous injection with GLP-2 plus Dex. It remains to be established what is the nutritional importance of this late effect of prior exposure to Dex or GLP-2 plus Dex on the intestinal uptake of lipids.
- adaptation
- cholesterol
- jejunum
- ileum
- late effects
- lipid binding proteins
- morphology
genetic programming is the main contributor to the development and maturation of the intestine (11, 17, 18, 27). Various stimuli influence intestinal ontogeny such as hormones, the enteric nervous system, the mesenchyme, and luminal factors including the luminal bacterial flora and animals' diet (23, 28, 30). The digestion and absorption of nutrients demonstrate age-dependent changes during the development of the gut due to alterations in the brush-border membrane (BBM) permeability and the BBM nutrient transporters or enzymes (6, 18, 34). A diet with a high content in lipids such as milk is well digested during the suckling period in rodents despite a low secretion of lipase and colipase by the newborn pancreas and lack of gastric lipases (14). The impaired pancreatic and gastric lipolytic process is compensated for by the lingual and milk lipases (17). Lipid absorption is a complex process involving the passive diffusion and protein-mediated transport of lipids across the BBM, their intracellular metabolism, as well as the subsequent transfer of the lipids into the lymphatics or into the portal circulation (2, 37). During suckling, the intestine is capable of an increased uptake of lipids compared with the weanling period (16, 15). This higher uptake results possibly from an increased fluidity of the BBM (19, 35) and/or a greater metabolism of fat in suckling compared with weanling or adult rats (15, 16). The age-dependent decrease of the BBM fluidity results from alterations in lipid composition of BBM. The suckling intestine contains greater amounts of cholesterol and phospholipids per milligram of protein compared with the mature intestine (35, 19). The decline in lipid uptake between the suckling and weaning period is associated with a change in the diet from a high uptake of fat in milk to a high intake of carbohydrates in rat chow.
In adult rats, glucagon-like peptide-2 (GLP-2) enhances the intestinal BBM and basolateral membrane (BLM) uptake of sugars (8–10) as well as triolein (4). Also, balance studies in human patients with the short bowel syndrome have shown that GLP-2 increases lipid uptake (24). It is not known whether this peptide influences the uptake of lipids in suckling animals. Glucocorticosteroids such as dexamethasone (Dex) increase the uptake of sugars and lipids in adult rats (39, 40) and accelerate the development of the transport and digestive functions of the young intestine (18, 30). Dex and GLP-2 may have a synergistic effect because Dex increases the activity of cAMP acting hormones, such as GLP-2, by altering the adenylyl cyclase catalyst (44). It is not known whether the combination GLP-2 plus Dex enhances the intestinal uptake of lipids in suckling rats or whether such an effect persists into the postweaning period.
Accordingly, this study was undertaken to determine 1) whether GLP-2 and Dex when administered alone or in combination to suckling rats enhance the intestinal in vitro uptake of lipids; 2) whether these changes in the uptake of lipids are due to variations in the intestinal mass or morphology or to changes in the abundance of selected intracellular lipid binding proteins in the enterocytes; and 3) whether the effects of GLP-2 and Dex on the intestine persist into the postweaning period.
The principles for the care and use of laboratory animals, approved by the Canadian Council on Animal Care and by the Council of the American Physiological Society, were observed in the conduct of this study. All experiments were approved by the Animal Ethics Board, University of Alberta. Eight nursing Sprague-Dawley rats with 64 suckling offspring were obtained from Bio Science Animal Services, University of Alberta.
The suckling rats were randomized into four groups that received treatment with GLP-2, Dex, GLP-2 plus Dex, or placebo. All animals received treatment for 10 days starting with the 11th day from time of their delivery. GLP-2 was administrated in a dose of 0.1 μg·g body wt−1·day−1 sc twice per day at 7 AM and 7 PM. Dex was administrated in a dose of 0.128 μg·g body wt−1·day−1 sc once per day at 7 PM. The regimen used for GLP-2 plus Dex group was GLP-2 0.1 μg·g body wt−1·day−1 sc twice per day at 7 AM and 7 PM plus Dex 0.128 μg·g body wt−1·day−1 sc once per day at 7 PM. The placebo group received 0.9% saline in a volume equal to the volume of GLP-2 administered daily per rat (depending on the weight of the rat, the volume ranged from 0.08 ml on the first day to 0.18 ml on the 10th day) subcutaneously twice per day at 7 AM and 7 PM.
There were eight animals in each group. After treatment, all sucklings were killed for uptake studies at 21 days of age, and all postweaning animals (weanlings) were killed for the uptake studies at 7 wk of age (Fig. 1).
The animals were housed at a temperature of 21°C, and each day they were exposed to 12:12-h light-dark cycle. During the suckling period, the offspring received only the dam's milk. The weanlings were housed in pairs. Their water and food were supplied ad libitum. The dams and the weanlings were fed standard rat chow (PMI #5001; Nutrition International, Brentwood, MO). The diets were nutritionally adequate, providing for all known essential nutrient requirements. Body weights were recorded at the time of weanling and then weekly for the next 4 wk.
Uptake Studies
Probe and marker compounds.
The 14C-labeled probes included cholesterol (0.05 mM) and six fatty acids (0.1 mM): lauric acid (12:0), palmitic acid (16:0), stearic acid (18:0), oleic acid (18:1), linoleic acid (18:2), and linolenic acid (18:3). The labeled probes were supplied by Amersham Biosciences (Piscataway, NJ). The lipid probes were prepared by solubilizing them in 10 mM taurodeoxycholic acid (Sigma, St. Louis, MO) in Krebs-bicarbonate buffer, with the exception of 12:0, which was solubilized only in Krebs-bicarbonate buffer. [3H]inulin was used as a nonabsorbable marker to correct for the adherent mucosal fluid volume (44).
Tissue preparation.
Eight animals per treatment group were killed by an intraperitoneal injection of Euthanyl (pentobarbital sodium, 240 mg/100 g body wt). The whole length of the small intestine was rapidly removed and rinsed with 150 ml cold saline. The intestine was divided into two parts: the proximal half of the intestine beginning at the ligament of Treitz was termed the "jejunum," and the distal half was termed the "ileum." A 2-cm piece of each segment of jejunum and ileum was gently scraped with a glass slide. The mucosal scrapings and the remaining wall of the intestine were dried overnight in an oven at 55°C. The percentage of the intestinal wall comprised of mucosa was calculated. The remaining intestine was everted and cut into small rings of ∼2–4 mm each. These intestinal rings were immersed in preincubation beakers containing Krebs buffer (pH 7.2) at 37°C, bubbled with oxygen plus bicarbonate (O2-CO2, 95:5 by volume), and were allowed to equilibrate for 5 min (32). Uptake was initiated by the timed transfer of the tissue rings from the preincubation buffer to a 5-ml plastic vial containing [3H]inulin and 14C-labeled lipids in Krebs buffer bubbled with oxygen plus bicarbonate that had been equilibrated to 37°C in a shaking water bath. The intestinal rings were incubated in the lipid substrates for 5 min.
Determination of uptake rates.
The rate of uptake of lipid was terminated by pouring the vial contents onto filters on an Amicon vacuum filtration manifold that was maintained under suction followed by washing the intestinal rings three times with ice-cold saline. The tissue rings were placed on a glass slide and were dried overnight in an oven at a constant temperature of 55°C. The dry weight of the tissue was determined, and the tissue was transferred to scintillation counting vials. The samples were saponified with 0.75 M NaOH, scintillation fluid was added, and radioactivity was determined by means of an external standardization technique to correct for variable quenching of the two isotopes. The rates of lipid uptake were determined as nanomoles of substrate absorbed per 100 mg dry weight of the mucosa per minute (Jm; nmol·100 mg mucosal tissue−1·min−1).
Morphological Analysis
To determine the morphological characteristics of the intestine, a vertical section was prepared from the jejunum and from the ileum. Hematoxylin and eosin-stained slides were prepared from paraffin blocks. Crypt depth, villous height, villous width, villous width at half height, and cell density were measured using the program MetaMorph 5.05r (Universal Imaging, Downingtown, PA). The group means were obtained based on 10 villi and 20 crypts per slide, with a minimum of four animals in each group.
Jejunal and ileal tissues were embedded in paraffin, and 4- to 5-μm sections were mounted on glass slides. The sections were heated and placed immediately in xylene (2× for 5 min each), followed by absolute ethanol (2× for 2 min each) and were then rinsed with tap water. The slides were incubated in a hydrogen peroxide/methanol solution and rinsed with tap water. Then they were rehydrated, and the tissue was encircled on the slides with a hydrophobic slide marker (PAP pen, BioGenex, San Ramon, CA). The slides were incubated for 15 min in blocking reagent (20% normal goat serum) followed by primary antibody to the intestinal fatty acid binding protein (I-FABP) or to the liver fatty acid binding protein L-FABP for 30 min. Both antibodies were a generous gift from Dr. L. B. Agellon, University of Alberta. The slides were incubated in LINK and LABEL and with DAB solution (BioGenex, San Ramon, CA). The slides were then washed, stained in hematoxylin, dehydrated in absolute ethanol, and cleared in xylene. The slides were photographed, and the area labeled with antibody was determined using MetaMorph 5.05r. The results were expressed as a ratio of the area that was antibody-positive versus the total area. Statistical analyses were based on a minimum of four villi per animal and four animals per group.
Statistical Analyses
The results obtained were expressed as means ± SE. The statistical significance of the differences between the four groups was determined by ANOVA for values of P ≤ 0.05. The significant differences between sucklings versus weanlings were determined using a Student's t-test. Statistical significance was accepted for values of P ≤ 0.05.
Body and Intestinal Weights and Villous Morphology
Injecting GLP-2, Dex, or GLP-2 plus Dex into the suckling animals for 10 days had no effect on the animal's body weight (data not shown). In contrast, the mean body weight of the weanlings injected 6 wk previously with Dex was ∼25% lower than in the control animals (162 vs. 213 g). When GLP-2 was given with Dex, the decrease in body weight in the weanlings given Dex was not observed.
Giving GLP-2, Dex, or GLP-2 plus Dex to the suckling rats had no influence on the jejunal or ileal weights, weight of the mucosa, or percentage of the intestinal wall comprised of mucosa (data not shown). In contrast, in weanlings, the total ileal weight was increased from 7.6 ± 0.8 mg/cm in controls to 10.1 ± 0.8 mg/cm (P < 0.05) in those given GLP-2 (data not shown). Neither Dex nor GLP-2 plus Dex influenced the intestinal characteristics in weanlings.
GLP-2 increased the crypt depth in the jejunum of sucklings, whereas Dex as well as GLP-2 plus Dex increased the jejunal villous height, width at the villous base, and crypt depth (Table 1). In the ileum of sucklings, GLP-2 decreased the width of five villi, Dex alone had no effect, whereas GLP-2 plus Dex increased all the morphological parameters of the intestine (Table 2).
In the jejunum of weanlings, GLP-2, Dex, and GLP-2 plus Dex increased the width of five cells, indicating an increase in enterocyte size; GLP-2 plus Dex also increased the villous height (Table 3). In the ileum of weanlings, GLP-2 by itself had no effect, Dex increased the villous height and cell size, whereas GLP-2 plus Dex decreased the villous width, crypt depth, width of five villi, and enterocyte size (Table 4).
Lipid Uptake
Because of the influence of GLP-2 and Dex on the morphology and characteristics of the intestine (Tables 1–4), lipid uptake was expressed on the basis of the weight of the mucosa (Jm; nmol·100 mg mucosal tissue−1·min−1).
In sucklings, GLP-2 had no effect on the jejunal or ileal uptake of lipids (Table 5). Dex increased the uptake of 18:3 in the jejunum. GLP-2 plus Dex had no effect on jejunal or ileal uptake.
In weanlings 4 wk after the previous injection of GLP-2, there was no difference in the jejunal or ileal uptake of lipids (Table 6). In contrast, Dex increased the ileal uptake of 18:0, and GLP-2 plus Dex increased the ileal uptake of 12:0, 18:0, 18:1, 18:2, and 18:3.
The ileal uptake of 12:0 and cholesterol was lower in weanlings than in sucklings (Table 7). Giving GLP-2, Dex, or GLP-2 plus Dex directly to the suckling rats did not affect this age-dependent decline in lipid uptake.
GLP-2 plus Dex did not change the abundance of I-FABP or L-FABP in the ileum of the weanlings (data not shown).
GLP-2 in a dose of 5 μg/day (∼0.16 μg·g body wt−1·day−1, slightly greater than our dose of 0.1 μg·g body wt−1·day−1) given for 10 days enhances the intestinal uptake of [14C]triolein in adult mice (4) and improves fat absorption measured by balance studies in humans (dose ∼0.01 μg·g body wt−1·day−1) (24). Also, the intestinal absorption of other nutrients, such as leucine (4) and sugars (8–10), is enhanced in adult rats after the administration of GLP-2. In contrast, when GLP-2 treatment was given subcutaneously for 10 days to the suckling rats, there was no effect on lipid uptake (Tables 5 and 6). GLP-2 had no effect on body weight in the suckling or weanling rats (data not shown), although in previous studies, GLP-2 enhanced the body weight of adults (24, 36). Also, GLP-2 has a trophic action on the adult intestine (12, 13). In sucklings, the total weight of the ileum was increased as well as the crypt depth (Table 2). Furthermore, when GLP-2 is given with Dex, there was a marked enhancement in the ileal morphology in the suckling rats. This suggests that GLP-2 given to suckling rats has a modest trophic effect, which may be facilitated by the coadministration of Dex.
The finding of only a modest effect of GLP-2 on intestinal morphology when given alone was surprising, because receptors for GLP-2 (GLP-2R) are present in the intestine of young rats, and, in fact, their level is higher at this time than in adults (7, 26). Of interest, Petersen and co-workers (33) showed a lack of any trophic effect for GLP-2 in the intestine of pigs when given before birth. Our data suggest that the GLP-2Rs in the young animals are capable of responding to this dose of GLP-2 with only very modest changes in the characteristics of the intestine but with no alteration in lipid uptake. Therefore, whereas GLP-2Rs are present in the developing intestine, the receptors may be less responsive to GLP-2 than those receptors found in the mature intestine. Clearly on the basis of our data, it is unlikely that GLP-2 would be useful to accelerate intestinal morphological development or to enhance lipid absorption in young animals.
Glucocorticosteroids such as Dex are capable of accelerating the ontogeny of the intestine, including enhancing the absorption of nutrients such as sugars and amino acids (5, 20, 21). Glucocorticosteroids also enhance the intestinal uptake of lipids in adult rats (39, 40). Dex increased the uptake of 18:3 (Table 5), and in the jejunum, this was associated with an increase in villous height, villous width, and crypt depth (Table 1). Thus Dex is capable of stimulating morphological changes, however, intestinal lipid uptake was largely unchanged.
A major finding in this study was the stimulating effect of GLP-2 plus Dex on lipid uptake into the ileum, not at the time of injection, but rather 4 wk later in weanlings (Table 6). This was not obviously due to any change in body weight (data not shown), intestinal characteristics (data not shown), villous morphology (Table 4), or the abundance of the enterocyte lipid binding proteins I- or L-FABP (data not shown). Other workers have also observed that changes in I-FABP abundance do not necessarily reflect alterations in lipid uptake (1, 43).
The late effect of early nutrition has been described previously, and the concept of "critical period programming" is documented (25, 30). For example, changes in the dietary content of carbohydrates, lipids, or proteins during the suckling or weanling period influence the morphology and/or the nutrient uptake in the intestine (25, 41, 42). Moreover, the maternal diet consumed during pregnancy and nursing influences the intestinal morphological development and the absorption of nutrients in the offspring (22, 31).
Thus, whereas GLP-2 does not appear to be stimulating to the suckling intestine, it does have an effect on the morphology and function of the postweaning intestine when combined with Dex. These studies did not establish the mechanism(s) of this late effect of GLP-2 plus Dex. The persistent enhanced uptake of lipids (Table 6) and trophic changes in the crypt-villous morphology (Tables 3 and 4) seen in the weanlings exposed 1 mo previously to GLP-2 plus Dex raises the possibility that these alterations may continue into later life and could, thereby, potentially contribute to unwanted abnormalities in lipid absorption. It would be important for future studies to clarify this issue and especially to determine whether there is continued hyperabsorption of lipids and whether this has any adverse influence on the animal's body weight later on or on the development of hyperlipidemia.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2005 the American Physiological Society


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By Lewis Carroll
The end result of a life of scholarship, The Annotated Alice is a landmark occasion within the wealthy historical past of Lewis Carroll and reason to rejoice the awesome profession of Martin Gardner.
For over part a century, Martin Gardner has confirmed himself as one of many world's best professionals on Lewis Carroll. His Annotated Alice, first released in 1959, has over part one million copies in print all over the world and is cherished through either households and scholars―for it used to be Gardner who first decoded a few of the mathematical riddles and wordplay that lay ingeniously embedded in Carroll's vintage tales, Alice's Adventures in Wonderland and Through the having a look Glass.
Forty years after this groundbreaking book, Norton is proud to submit the Definitive version of The Annotated Alice, a piece that mixes the notes of Gardner's 1959 variation along with his 1990 quantity, More Annotated Alice, in addition to extra discoveries drawn from Gardner's encyclopedic wisdom of the texts. Illustrated with John Tenniel's vintage, loved art―along with many lately came across Tenniel pencil sketches―The Annotated Alice might be Gardner's most lovely and enduring tribute to Carroll's masterpieces yet.
colour, two-tone, and black-and-white images and illustrations all through
Quick preview of The Annotated Alice: The Definitive Edition PDF
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Extra resources for The Annotated Alice: The Definitive Edition
Portsdown street. June 1, 1870 file:///E|/Stuff/E-Books/Alice/ALICE. HTM (105 of 223)12/22/2005 16:50:31 The Annotated Alice advent sooner than the Wasp episode got here to gentle, such a lot scholars of Carroll assumed that the misplaced episode was once adjoining to, a minimum of now not faraway from, the railway carriage scene. This was once simply because Tenniel, in his letter of criticism, looked as if it would hyperlink the 2 incidents. In bankruptcy three, the place Alice leaps the 1st brook and the educate jumps over the second one, Alice encounters various bugs, together with bees the scale of elephants. used to be it now not applicable that she might meet a wasp during this sector of the chessboard? That Carroll didn't intend Alice to come back upon the Wasp so early within the chess online game is clear straight away from the numbers at the galleys, and from what Alice notion whilst the Wasp instructed her how his ringlets used to wave. "A curious proposal got here into Alice's head. nearly each she had met had repeated poetry to her, and he or she concept she could test if the Wasp could not do it too. " the 1st individual to recite poetry to Alice is Tweedledee, and the second one is Humpty Dumpty. The misplaced episode, for this reason, needed to take place later than bankruptcy 6. the unfinished first line of the galleys leaves without doubt that Sotheby's catalog thoroughly shows the place Carroll had meant the Wasp episode to head. (The spot is proven by means of the arrow within the copy of web page 183 of the 1st variation of during the Looking-Glass, right here published on web page 292. ) Alice has simply waved her ultimate farewell to the White Knight, then long gone down the hill to jump the final brook and develop into a Queen. "A only a few steps introduced her to the sting of the brook. " rather than a interval there has been a comma. The sentence persisted as on the most sensible of the 1st galley: "and she used to be simply going to spring over, while she heard a deep sigh, which looked as if it would come from the wooden in the back of her. " either Tenniel and Collingwood referred to as the episode a "chapter," yet there are problems with this view. The galleys supply no indication that they're something yet an excerpt from bankruptcy eight, and it sort of feels not likely that Carroll might have sought after his moment Alice e-book to have 13 chapters while the 1st publication had twelve. it really is Morton Cohen's trust that Tenniel, writing "in an ache of haste," used the observe "chapter" while he intended episode. Collingwood's feedback are simply defined as gildings of the way he interpreted Tenniel's letters. (There should have been no less than another Tenniel letter on hand to him, as the comment of Tenniel's that he costs a couple of wasp in a wig being "beyond the home equipment of paintings" doesn't seem within the letter he reproduces in facsimile. ) One may perhaps argue that had the Wasp episode belonged to the White Knight bankruptcy, the bankruptcy may were uncommonly lengthy, and wouldn't Tenniel have written that the episode will be got rid of to "shorten the bankruptcy" instead of "shorten the book"? however, the truth that the bankruptcy was once too lengthy can have been one more reason why Carroll was once prepared to excise the episode.


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