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A mother who posted a photo of her 18-month-old daughter holding up her shirt on Instagram had her account shut down because the image violated the website's decency rules.
Courtney Adamo branded the photo-sharing site "ridiculous" after receiving a warning email which told her the photo, featuring the toddler wearing yellow welly boots and knickers staring down at her belly button, was "inappropriate".
The photo was then automatically deleted from her feed.
The mother-of-four checked the Instagram guidelines and, convinced she had not broken any codes of conduct, reposted the photo.
But a few hours later she discover her account had been shut down, blocking all of her 1,700 pictures.
She said: "It is so ridiculous. I've been in touch with a few other mums who told me the rules state any children of walking age can't be shirtless in pictures on the site.
"My daughter is so young and you see adverts with children in just their nappies all the time and no one says that is inappropriate or sexual but Instagram does, it's crazy.
Courtney Adamo with her daughter Marlow (SWNS)
"They obviously see it as child porn but I thought it was such a sweet photo of my baby girl and her gorgeous, round belly and outie belly button.
"And I love that her pride is so evident in the photo, such a sweet and innocent shot of a successful day of potty-training."
Mrs Adamo, a blogger for the online boutique Babyccino Kids, was told the photo of little Marlow had "violated community guidelines".
He defended her actions on her blog, writing: "She is a baby!
"It is no different than a photo of a baby wearing a nappy, or a little boy in swimming trunks, and to entertain the idea that it is even remotely inappropriate is a disgusting thing in itself."
The American-born mother, who now lives in Highgate, north London, with husband Michael and their four children, uses Instagram to share photos with her family and friends back in the US so was devastated at the loss of all her images.
"Instagram has deleted four years of my family photos and memories," she said.
"All the photos of our travels, my children's birthdays… All of it gone.
"I am sick just thinking about it."
Her Instagram page, which has 40,000 followers, was later reinstated without the photo of Marlow after a number of followers backed her by posting photos of their own children showing off their bellies.
A spokesman for Instagram, which was bought by Facebook in 2012 for €1billion, said: "We try hard to find a good balance between allowing people to express themselves creatively and having policies in place to protect young children.
"This is one reason why our guidelines put limitation on nudity, but we recognise that we don't always get it right.
"In this case, we made a mistake and have restored the account."


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Single Row Sculptural Bib Necklace
Single Row Sculptural Bib Necklace
Made to Order. Allow 2-3 weeks to ship.
Multiple curves delicately play around your neck in this single row bib necklace.
- designed in brass, cast in lightweight white metal
- necklace measures 17"
- lobster closure
- brass findings, steel chain
- imitation rhodium plating ( no tarnishing!)
Add To Cart

subset: commoncrawl


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Loyola University New Orleans student projects
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Find information about Loyola University New Orleans student projects, and registering for discussion sections and departmental electives. As a student, your first stop should be the registrar's office, where you can pick up a free copy of both the academic calendar and course catalog, in order to find available credit classes that you may be interested in taking. You may be surprised that you can enroll for a full-time course load, without having to attend any 8am classes at all. Finally, check with your major department for assistance with prerequisites, tuition payment deadlines, and Loyola University New Orleans student life information. Please use the form above to request admissions info for Loyola University New Orleans.
Don't imagine that college is all about getting good grades and finding a job after graduation. A large part of the university growth experience is about participating in extracurricular activities such as student government, writing for the school newspaper, or joining one of the many student clubs on campus.
It isn't necessary to take a leadership position in a student organization on campus, in order to enjoy contributing to student life at your school. Sure, you have to live somewhere, but spending your freshman year in the dorms can give you the added benefit of making friends and establishing a social circle. Consider signing up for a meal plan, and gaining 10 pounds in the dining hall. Again, the purpose is to socialize and meet other students outside the classroom. Beyond consideration for Loyola University New Orleans student projects, you may think about Central Texas College advanced placement tests for complementary electives to your primary course of study.
Admissions Advisor
Lehman College
And advising prospective applicants on the graduate admissions process and opportunities at the College. Supervise Graduate College Work Study students.
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Grand Canyon University
Serves as liaison to the admissions offices at medical/graduate schools to promote the College programs and to gather/disseminate up-to-date information on..
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College of Healthcare Professions
Adhere to standardized college admissions guidelines and procedures for certificate and degree completion. This position supervises all assigned personnel.
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Bryant & Stratton College
Ability to exercise judgment in the application of college policies and procedures. Maintain professional relationships with admissions representatives.
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Contra Costa Community College District
Contra Costa College. Contra Costa College is a dynamic, comprehensive community college with a diverse student population.
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Franchise Opportunity in Houston, Texas
Why Open a Spa Franchise in Houston?
The spa industry is expanding, and Marilyn Monroe Spa franchises are expanding with it. We are looking for someone dedicated, hard-working, and passionate to open our newest spa franchise in Houston, Texas!
Houston is the ideal location for a Marilyn Monroe Spas for two main reasons. First, the city is experiencing enormous growth in population and economy. Second, your Houston franchise will be able to utilize the variety of valuable business resources that are available in the city.
A Marilyn Monroe Spas franchise is a smart investment in Houston, as the spa industry continues to thrive. This multi-million dollar industry is shifting away from being considered a luxury as more people consider self-care a necessary expense. Opening a franchise in Houston is a great way to start your career as a business owner.
Economic Growth
As Texas has experienced a recent economic boom, Houston has certainly been no exception. Houston is one of the fastest growing cities in the nation, with a population only smaller than New York, Chicago, and Los Angeles.
In 2014 alone, nearly 20,000 people moved to Houston. Indeed, Houston according to a study done by U-Haul, more people move to Houston than anywhere else nationwide. This exponential population growth is great news for your franchise, as you will have an ever growing customer base.
Additionally, as the population continues to grow, you can grow your business by opening additional franchises in Houston. The economy has kept up with the population growth, so the well-employed population of Houston is likely to have the discretionary income to spend on such things as facials, massages, and luxury hair treatments.
Business Support Network
Part of the reason that Houston's economy has been able to remain so strong even with so much population growth is that the city has invested time and resources in organizations dedicated to helping small businesses succeed. Most notable of these is the Economic Development Division, or EDD.
The EDD can help your Houston franchise with a number of aspects of opening, owning, and operating a business. This faction of the city government helps foster job creation and small business development by influencing city policy.
The EDD has been involved in creating incentives for businesses to open or relocate in Houston including tax breaks. For example, there are certain zones in Houston in which the city wants to stimulate growth. If your Houston franchise opened in one of these areas, there are numerous tax benefits for doing so.
There is no time to waste! Opening a Marilyn Monroe Spas franchise in Houston is a smart investment that will jumpstart your career as a business owner. If you are ready to work toward your own business goals instead of someone else's, click this LINK and get started right away.
- http://www.forbes.com/places/tx/houston/
- http://www.houston.org/newgen/10_Employment_and_Workforce/10C%20W001%20Unemployment%20Rate.pdf
- http://www.houstontx.gov/ecodev/tirz.html


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Format: Unknown Binding
Language: English
Format: PDF / Kindle / ePub
Size: 5.29 MB
Downloadable formats: PDF
Pages: 350
Publisher: Grenich (1967)
For A Pagan Song: In the Footsteps of the Man Who Would Be King - Travels in India, Pakistan and Afghanistan by Bealby, Jonny New Edition (1999)
Geological Map of the Central Karakoram Mountains
A Journey Interrupted: Being Indian in Pakistan
Pakistan (Modern Nations)
Notes from My Travels: Visits with Refugees in Africa, Cambodia, Pakistan and Ecuador by Angelina Jolie (1-Dec-2003) Paperback
Narrative of various journeys in Balochistan, Afghanistan, the Panjab, & Kalât, during a residence in those countries: To which is added an account ... at Kalat, and a memoir on Eastern Balochistan
Gazetteer of the Gujranwala District 1883-84
The Government has done little to stem the flow of women trafficked into the country or to help victims of trafficking. For example, despite the estimated thousands of women involved, only 88 cases were registered in Sindh between 1990 and 1999. Of the 260 men and 110 women arrested, 87 were charged and only 7 were sentenced , cited: Murray's Handbook for download epub download epub. Karachi is in the south of the nation and in addition to being a modern city on the shores of the Arabian Sea, it has a number of interesting sites, including the Masjid-e-Tooba which is said to be the largest single-dome mosque, and several art galleries and bazaars. It has a wide variety of water sports and remains the center of commerce and industry , e.g. Where Three Empires Meet: A download pdf designosource.be. Number and Share of International Students in the United States from the Top Ten Asian Origin Countries, 2014-15 School Year Source: MPI tabulation of data from the Institute of International Education (IIE), "International Student Totals by Place of Origin, 2013/14- 2014/15," Open Doors Report on International Educational Exchange (New York: IIE, 2015), available online download. For example, field corn grown, harvested and stored on a farm and then fed to livestock on that farm has value. In fact, value usually is added by feeding it to an animal, which transforms the corn into animal protein or meat. The value of a changed product is added value, such as processing wheat into flour. It is important to identify the value-added activities that will support the necessary investment in research, processing and marketing Punjab Province Map / Scale read epub Punjab Province Map / Scale 1:100,000. The apex court will decide her fate on October 13, Thursday when her appeal against death sentence will be heard Pakistan Industrial and download online http://hazladetos.bicired.org/?lib/pakistan-industrial-and-business-directory. The Motorsport Association of Pakistan (MAP) is a member of the Federation Internationale de L'Automobile FIA. The Pakistan National Karting Championship was the first motor racing curcit competition in Pakistan, and is used to develop rookie drivers. The Freedom Rally is a yearly off-road race which takes place during the Independence celebrations AND THERE I WAS VOLUME III: A read online webgisjakarta.info.
A handbook for travellers in India, Pakistan, Burma and Ceylon
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The United States and India and Pakistan (American foreign policy library)
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Rated 4.8/5
based on 517 customer reviews


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Wedding decorations, party supplies, home décor & craft supplies up to 60% off. Save On Crafts brings you classic and trending fashions.
The Palm Leaf Fans are a natural item, the size of the frond will be in the range of 15 to 24in tall including the stem, with the leaf heads range from 5.5in to 14in wide, and 6in to 12in tall. These pieces have been dyed green.


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Welcome to a Sample of the Art I love to create!
I am wildly interested in abstract art with layers of paint, ink, paper, text & nature inspired imagery. Each artwork has many hours of love & light infused into it. I work intuitively meaning I do not hold onto a fixed idea when creating, but rather go with the flow, surrender & see where the creative spirit wishes to take me- more often than not it is on a beautiful adventure! It is such a fun & meaningful way to create & one that I cherish. I often say that Art is my Sanctuary, a place to process, relax, heal & explore. What happens on the canvas can then be taken into life. It is an all encompassing, soulful experience that I am truly grateful for! I hope you enjoy what you see...
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"The Best Little Bookshop In Town Cronulla"
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"The Best Little Bookshop In Town Cronulla"
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Manuel Clavel Rojo, Jacob Brillhart and Co. are working round the clock on their installation "Up-Downtown", for the DawnTown Design/Build grand opening at HistoryMiami. Below are some photos taken at their warehouse located in Little Haiti. Many thanks to McKenzie Construction for helping out in this worthwhile endeavor.
You can still RSVP at firstname.lastname@example.com. Tickets will also be available at the door.


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anyone know if there is a script that will show you a real time hourly wage? I have mturk wage reporter but its not working. I just want to know what kind of hourly rate I'm getting
i wonder when i'm going to lose my first hand
it should be soon..
It will put a start/stop button in the upper right corner and wage.
Thanks: (1)
Title: 15 mins survey-- make judgments about media(~ 15 minutes) | PANDA
Requester: M Takarangi, D Strange [A2LQ4N9RDPSDIX] (TO)
TO Ratings:
★★★★★ 3.16 Communicativity
★★★★★ 2.49 Generosity
★★★★★ 4.22 Fairness
★★★★★ 4.06 Promptness
Number of Reviews: 199 | TOS Flags: 8
Submit a new TO review
Description: Answer questions about news headlines and photos
Time: 60 minutes
HITs Available: 1
Reward: $1.50
Qualifications: Exc: [1883933774-34857] has not been granted;Total approved HITs is not less than 1000;HIT approval rate (%) is not less than 95;Location is one of: US
Good batch. All mine approved last week.
Title: Mark whether two questions have the same meaning or not | PANDA
Requester: Abdalghani Abujabal [A1WJHLMN6HZTYA] (Contact)
TO: [Pay: N/A] [Fair: N/A] [Comm: N/A] [Fast: N/A] [Reviews: 0] [ToS: 0]
Description: Given two questions, decide whether they have the same meaning or not.
Time: 60 minutes
HITs Available: 406
Reward: $0.07
Qualifications: Masters has been granted;
Thanks: (1)
Title: A Study on Taste Perception(~ 5 minutes) | PANDA
Requester: SurveyComet [A3NC2P2SPK9QQ] (Contact)
TO: [Pay: 4.26] [Fair: 4.84] [Comm: 4.33] [Fast: 4.72] [Reviews: 408] [ToS: 1]
Auto Approval: 30 days
Time: 10 minutes
HITs Available: 1
Reward: $0.50
Qualifications: TP Panel: 1217719246 N is not less than 100; Total approved HITs is not less than 50000; Exc: [35443-34854] has not been granted ; HIT approval rate (%) is not less than 95; Location is one of: US;
11 min
Title: Take a test on your general knowledge and cognitive abilities(~ 20 minutes) | PANDA
Requester: Darden Behavioral Lab [A1Z3WDC2OU0760] (Contact)
TO: [Pay: 4.43] [Fair: 5.00] [Comm: 4.25] [Fast: 4.86] [Reviews: 24] [ToS: 0]
Description: 1.75 for 20 minutes (or less)
Time: 1 hour
HITs Available: 12
Reward: $1.75
Qualifications: Exc: [35428-34839] DoesNotExist ; Location In US;
Last edited by Flora; 02-26-2017 at 07:52 AM.
The HITs available is staying at 406 so it's going to be up for awhile. Once it goes down, it'll go down fast.


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Join us for an information workshop on Bankruptcy presented by Attorney Patrick Kavangh.
The Second Monday of each Month.
From 12:15pm - 1:15pm
Come learn about the bankruptcy procedure and what are the affects of filing. Also covered will be other options that may be available rather than filing bankruptcy.
Preregistration not required.
|How to Probate a Small Estate
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Join us for a monthly iinformation workshop presented by Attorney Diane Dodds.
Held the First Wednesday of Each Month
12:15 -1:15
The workshop covers small estates of $150,000.00 or less. Information will be provided on the various options available in dealing with a small estate as well as procedures that may be avialable to aviod probate.
Preregistration not required.
|Free Post-Conviction Relief Seminar for Criminal Defendants September 21, 2017
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September 21, 2017 5:30pm Kern County Supertindent of Schools Building 1300 17th Street Room 1A Bakersfield, CA 93301
Several local criminal attorneys will be be providing information about Proposition 47, Expungements, Restoration of Gun Rights, Habeas Relief and other methods of lessoning the effects of a criminal conviction.
Attorney Roger Lampkin will also be holding a book signing in conjunction with the release of his latest book , Handbook for the Accused.
Preregistration is not required.


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Printer Repair Questions? Ask IT Technicians for Answers ASAP
Hello, I'm Wes, and I'll be assisting you today.
Since you have done the cleaning already, which is usually the problem, the problem is with the actual rollers or motors that pull the rollers.
They can also go bad and stop pulling paper properly. Even the gears can break and cause the rollers to stop pulling the paper or impede the rollers as well. The problem is that the printer will need to be serviced to find out which part will need to be replaced. Unfortunately, this means that it will need to be taken to a printer service center. It it most likely more cost effective to purchase a new printer that is under warranty. Sorry for the bad news.
Let me know if you need additional help so I can assist further.Also, please rate my answer below so based on your satisfaction.Thank you.


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BlaBlaCar Chooses Nexmo to Help Connect Nonprofessional Drivers with Passengers Globally
Nexmo SMS API Helps BlaBlaCar Maintain Superior Communication With Customers Across the World
Mar 08, 2016, 02:00 ET from Nexmo
SAN FRANCISCO, March 8, 2016 /PRNewswire/ -- BlaBlaCar, the world's largest ridesharing community, with more than 25 million members across 22 countries, is using Nexmo, the global cloud communications platform leader, to help increase its messaging quality through the use of Nexmo's powerful APIs. As part of its effort to connect humans and make long-distance ridesharing reliable and mainstream, BlaBlaCar is using Nexmo's SMS API to deliver over 100,000 SMS messages each day to connect and verify users, while decreasing telecommunication costs as much as 15 percent.
"For over a year, Nexmo has helped us ensure our community is getting the most reliable communications and deliver the best service possible," said Nicolas Schwartz, technical lead at BlaBlaCar. "Communication is one of the pillars of reliable transportation—when you're arranging for a ride, you want the immediacy of text messages, especially when things change. Driver and passenger satisfaction is crucial for us, and Nexmo provides the solutions we need for the satisfaction of our community."
BlaBlaCar revolutionized the ridesharing space by allowing nonprofessional drivers to offer rides in their cars for long-distance travel to help offset costs. In order to verify people's identities upon signup and allow people to arrange rides, the company needed the ubiquity and immediacy of SMS and voice messaging. After researching a number of tools, BlaBlaCar found that Nexmo's cloud communication platform was easy to integrate, provided direct-to-carrier connections for enhanced message quality, plus found Nexmo Adaptive RoutingTM identified the shortest yet most reliable route for each SMS or voice message sent, while ensuring extensive international coverage.
"It's inspiring to see how BlaBlaCar is revolutionizing the way people connect and travel, and we're proud to be a part of the shared economy wave," said Cyprien Godard, France country lead for Nexmo. "We built our platform for disruptive companies like BlaBlaCar to easily integrate communications capabilities that result in compelling products and user experiences."
About Nexmo
Nexmo is the global cloud communications platform leader providing innovative communication APIs and SDKs for voice, text, messaging and phone verification services. Nexmo enables applications and enterprises to communicate with their customers reliably and with ease, no matter where in the world they are located. High-volume communication companies such as Alibaba, Tencent and Viber send millions of messages per month using Nexmo APIs. Nexmo was recognized by analyst firm Gartner as a 2014 Cool Vendor in Communication Services, has been recognized by Roaming Consulting Company as a Tier 1 A2P SMS Messaging Vendor in 2015 and was selected as an Aragon Research Hot Vendor in Real-Time Communication and Collaboration Platform as a Service in 2015. http://www.nexmo.com
SOURCE Nexmo


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Continental Europe grabs 2-point lead in Paris
By Mark Thompson @MarkThompsonCNN October 3, 2013: 8:27 AM ET Greek Prime Minister Antonis Samaras has stuck to the task of painful economic reforms. LONDON (CNNMoney) Investors are scouring Europe for ways to make money from its tentative recovery, and one U.S. firm thinks it has found the answer — buy Greek government bonds. Japonica Partners said it believed Greek debt was "massively undervalued" and should be rated several notches above the junk status assigned by the big credit rating agencies. Greece has been shut out of international bond markets since 2010, when its government borrowing spiraled out of control. It has been rescued twice by the European Union and International Monetary Fund and was forced to restructure its debt in March 2012, imposing losses of more than 100 billion euros on private bondholders. Related: Europe's recovery is weak, warns ECB But hedge funds — such as Dan Loeb's Third Point — and other niche investors who bought into Greek debt since the restructuring have made a killing. Yields on Greek 10-year debt in the secondary market have plunged from around 44% in March 2012 to 9%. Japonica's statement was greeted with derision by some investors Thursday, but the firm that made its name restructuring bankrupt Allegheny International in the early 1990s believes it has spotted an opportunity others may have missed. It claims to have become one of the larger, if not the largest, holder of Greek government bonds, and has hired a former senior executive from Norway's oil fund — one of the world's biggest investors — to help manage the portfolio. Related: Investors embrace European stocks "Greece is one of history's most extraordinary sovereign rejuvenations hidden in plain sight by pervasive systemic misperceptions," Japonica said, adding it expected yields should break below 5% in 2014. It's a bold prediction but Japonica may have a point. Greece's headline economic data and social crisis remain as depressing as ever, and it may yet need another 10 billion euros in support. Still, the government is on track to deliver a primary budget surplus — stripping out the cost of servicing its massive debt this year — and hopes to return to the bond market in the first half of 2014.
Europe's tentative recovery spreads south in September
Nino Randazzo/Health Care Service/AP Enlarge Rome A boat packed with African migrants headed to Europe caught fire, capsized, and sank Thursday off the tiny Italian island of Lampedusa , killing more than 90 people and leaving 250 missing, officials said. The Christian Science Monitor Weekly Digital Edition The tragedy was the latest in a series of maritime incidents involving Europe-bound migrants, tens of thousands of whom flee war-torn and poverty-stricken countries in Africa and Asia every year seeking European prosperity. The boat carrying an estimated 500 men, women, and children, mainly from Eritrea and Somalia, was traveling from the Libyan coast when the fire broke out at dawn near Lampedusa, an island just 86 miles from Tunisia . RECOMMENDED: Think you know Europe? Take our geography quiz. As the fire raged, terrified migrants rushed to one side of the 65 foot-long boat, causing it to capsize about half a nautical mile off the islands coast, officials said. The Italian coast guard rescued about 150 people but another 250 were still missing hours after the disaster happened, said Antonio Candela, a government health commissioner. Italian television showed recovered bodies lined up along the quayside of the islands tiny port. More than 90 bodies had been recovered by midday Thursday, according to Angelino Alfano, a deputy prime minister. "It's horrific, like a cemetery. They are still bringing them out," said Giusi Nicolini, Lampedusas mayor.
Nomura's Matthews said they suggested a slightly stronger rate of growth for the final months of the year. STILL NOT ON SOLID GROUND Markit's Eurozone Services PMI rose to 52.2 in September from August's 50.7, little changed from a preliminary reading of 52.1. Readings above 50 signify growth. Businesses in No.1 economy Germany reported rising new orders and staffing levels, while France's private sector grew for the first time in a year and a half. The upbeat mood was further bolstered by news that euro zone retail sales jumped 0.7 percent in August, month-on-month, hitting the top end of forecasts. Draghi said on Wednesday the euro zone economy still faced downside risks [ID:nL6N0HS2YP]. Chris Williamson, Markit's chief economist, said the surveys pointed to slightly stronger growth towards the end of this year, even if the region was not out of the woods. "The political instability that has reared up in Italy is a reminder that there remains plenty of scope for recoveries to be derailed," said Williamson. Italian Prime Minister Enrico Letta won a confidence vote in parliament on Wednesday after Silvio Berlusconi, facing revolt in his own party, backtracked on threats to bring down the government. The Italian services PMI topped the 50 growth threshold last month for the first time since May 2011, which could signal a timid recovery towards the end of the year. British business again showed the fastest pace of growth among Europe's major economies last month. Although the Markit/CIPS UK Services PMI eased to 60.3 from August's near seven-year high of 60.5, it still showed strong momentum in British business, helped by a recovery in the housing market. "Such strong confidence also suggests that the UK economy has enough momentum to end the year strongly," said Christian Schulz, senior economist at Berenberg Bank. Financial markets were little changed on the data, taking their direction instead from the U.S.
Greek bonds: Europe's hidden gem?
"It was a great experience for them, but the main thing is to win points and I think the team is really happy today." Early Thursday, it appeared to be more of the same for GB&I, which has captured the Seve Trophy six straight times, which includes a 15 1/2 – 12 1/2 victory in the previous meeting. Jimenez gave his side the early lead when he birdied the first, but Gallacher matched the Spaniard's birdie at the third, then crucially saved par at the fifth to remain 1-down. Lawrie helped square the match at the par-5 seventh when he hit driver to the green with his second shot from 257 yards out, setting up a winning birdie. Gallacher then gave his side the 1-up lead with a 20-foot birdie putt at the next, and a par at the 10th doubled the Scots' advantage. Jimenez's birdie at the 11th narrowed the margin to one, but Gallacher matched Bjorn's chip-in birdie at the 14th with a make from 12 feet, and consecutive birdies at the 15th and 16th sealed the lone victory for GB&I. "It's always nice to win," said Lawrie. "Obviously there is a little bit more pressure when you are going out there first, you want to get a point on the board which we managed to do and we both combined very well today." GB&I couldn't sustain the early success, however. The last match to start was actually the second to finish, as Colsaerts and Fernandez-Castano breezed past Warren and Jamieson to earn Continental Europe's first point. Colsaerts, a Ryder Cup standout at Medinah, and Fernandez-Castano never trailed after notching birdies at the first and third to go 2-up. They were 1- up through 10 after a GB&I birdie there, then closed with three birdies and an eagle over their final five holes to wrap up the convincing victory. Ilonen and Olesen were 2-up with three to play before both players found the water at the 16th. Fleetwood and Wood got one back there, but were unable to get any closer, as Ilonen and Olesen closed out the win with pars at Nos. 17 and 18. GB&I appeared poised to earn a point in the next match, as Casey and Khan took a 1-up lead into the final hole, but Molinari managed birdie at the last to halve the match, and Luiten and Bourdy closed out Continental Europe's successful opening day with a 2 & 1 win over Donaldson and Lynn.


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Saline Environmental Commission
Thursday, 2017 Apr 20th
Saline Main Street along with the Saline Environmental Commission invite you to "Clean Saline", on Saturday April 22, 2017, Earth Day. After a...
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Thursday, 2017 Apr 06th
The economy has rebounded and that means Saline residents are filling their garbage cans..
Saline City Council heard about the activities...
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Thursday, 2016 Nov 17th
Monday's Saline City Council meeting was preceded by a party of sorts to honor veterans. Cake and beverages were served as council members and...
0 comments


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Up to 50% OFF CHRISTMAS GIFTS: Cards, Posters, T-Shirts, Mugs and more! | Ends Soon! | Use Code: UNIQUEXMAS4U | See Details
Abstract Berries Blue Serving Tray
per serving tray
15% off with code UNIQUEXMAS4U
About This Product
- Sold by
Size: Small Serving Tray
Entertain in style with this customized serving tray! Printed in full color, the serving tray comes in two sizes with a black or natural wood finish. Personalize with your photos, texts, and designs for a high quality serving tray that's perfect to match your décor or send as a gift to your favorite hostess.
- Dimensions: 14.5" w x 10" l x 2.125" d
- Designs printed in full color on high quality hardboard panel with glossy finish
- Available in black or natural wood finishes with handles on two sides
Will be made by
Picture It On Canvas
Poway, CA
About This Design
Abstract Berries Blue Serving Tray
Abstract berries, digitally manipulated photography image. Use this design, edit it, or fully customize one of your own. Image copyright Melissa Reese Peterson. Copyright does not transfer with sale.
Artwork designed by
Melissa Reese Peterson Photography
Groveland, NY
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Discount, Cheap Skateboards and Skateboard GearINCREDIBLE SALES ON CHEAP SKATEBOARDS AND SKATEBOARD GEAR! Check out dozens and dozens of discounted complete skateboards and skateboard wheels, trucks and accessories. Completely customize your board with awesome discounted gear. Shop awesome brands like Darkstar, Element, Enjoi, Speed Demons, Cliche and more!
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- Color: Yellow
Discount, Cheap Skateboards and Skateboard Gear
Almost Captain Caveman Skateboard Complete - Kids
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Blind Beckett Spirits R7 Skateboard Deck
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Creature Creaturemania Bingaman Skateboard Deck
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Meat and Nuts Breakfast™ Made Easy – Yak Recipe
Wednesday, 09 November 2016
I always talk about the importance of a good breakfast, my favorite being the Meat and Nuts Breakfast™. The saying that breakfast is the most important meal of the day is very true. Not only will it sets your neurotransmitters for the remainder of the day, it will also give you energy and focus. If
- Published in NUTRITION
Exogenous ketones, how the hell did I get here, and who are these people?
Monday, 08 August 2016
Guest blog by Paul Carter of Lift-Run-Bang.com This article is about seven months in the making So if I don't bore you, which I do my best not to (like writing 6,000 word articles on something as trivial as butt wink), then I hope you'll hang in there long enough to get through this one.
- Published in SUPPLEMENTATION
Learning from the Masters, Part 2 – Larry Scott -UPDATED
Tuesday, 29 March 2016
Six Lessons on Building Large Arms from Larry Scott In respect to the giants who have taught me loads on training. In this part 2 of the series on learning from the Masters, I want to pay tribute to Larry Scott. Anyone who has studied the Iron Game for an extended period time know that
- Published in TRAINING
Top Five Benefits of Meditation
Thursday, 28 January 2016
It's being said that our stress level is a hundred times that of our ancestors just a century ago With stress being called "the illness of the 20th century", it's no surprise that stress management is now a trend. And what's worse, the 21st century doesn't seem to fare better, stress-wise. Among the many methods put forth
- Published in GENERAL
Champions Use the Power of Pressure
Friday, 06 February 2015
Guest blog by Steve Fraser, USA Wrestling national coach I recently read the quote, "pressure is a privilege" by the great tennis player, Billy Jean King. It means that an athlete gets to experience the thrill of a big moment. If the big moment really did not matter then there would be no real thrill
- Published in GENERAL
Guayusa : A Healthy Alternative to Tea and Coffee
Monday, 11 August 2014
Tea and coffee are always popular drinks, especially in the morning. But not everyone can enjoy them, for various reasons. In this video Strength Sensei talks about an healthy alternative. This beverage harnesses the goodness of guayusa. Making it an ideal drink for morning energy and alertness. Besides, it is certified organic and respects fair
- Published in NUTRITION
Transcendental Meditation® In Practice: Include Meditation in Your Workout Routine
Tuesday, 04 February 2014
Transcendental Meditation® Is Definitely Something I Regret I Did Not Learn Earlier… Over the years, working with over 23 different sports, I was exposed to many sports psychologists and their takes on mind-building for sport. Transcendental Meditation® was one of the tools proposed. If someone were to ask me "What is something you regret not having learned earlier?",


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Blister with 1 miniature: Dactyls (Engineer)
New release! A new model and also a new troop profile for the ALEPH army. The Support Corps of the Steel Phalanx is composed entirely of specialists, both combat engineers and field medics. The Dactyl Engineers are master demolishers and an interesting option to accomplish objectives when playing missions or scenarios.


text: Human Rights Observatory Rwanda to Screen US, Spanish Travelers for Ebola The East African nation of Rwanda is ordering travelers from the United States and Spain to phone daily medical reports to health officials because of Ebola. These are the only two countries outside of Africa to report cases of the deadly disease. Anyone who was been to these two nations must report in to officials for the first 21 days of his or her stay. Rwanda is currently Ebola-free and determined to stay that way. It is already banning visitors from Guinea, Liberia, and...Read complete article© Voice of America - Tuesday, October 21, 2014


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Hey Guys! Sorry about not posting yesterday, we were doing human simulations of this year's game. What is a human simulation? A human simulation is when we all take the game and essentially play it by pretending that we are the robots. To pretend that we are robots we have to rely on only using slower and more mechanical movements in order too accomplish our assigned task. This ended up being a blast and you can see a picture of our simulation below. Using the simulation we predict that most robots will be able to do about 4-5 gears by themselves. Shooting robots will be able too shoot 20-30 balls at a mediocre normal throwing speed. Apart from our simulation our actual robot is starting to come together! The feeding mechanism has actually been attacked to a drive train, so it now actually does resemble a robot. (So Gene you could say we have a robot now). Currently we are discussing potentially where to put the electrical board and other components that will actually you know, make the robot move. Hope everyone has a wonderful weekend!
Category Archives: Uncategorized
(**warning: title contains spoilers)
I entered the arena on Thursday morning with high hopes. We had an amazing robot, a unique autonomous, and more practice than any other year, but when you're a south Florida FRC team whose only reputation is "Spirit award winner", placing confidence in victory is nothing short of foolish. But practice day went pretty well, and aside from a few very aggressive inspectors, we retained our optimism.
Friday: Qualifying rounds.
We started the day extremely well, setting the high score in our second match and remaining the only robot in the competition with a solo stacked tote autonomous. Andrey and Damian drove with confidence and ease and Prajesh quickly learned the mechanics of the tote chute. We were ranked first seed for the first time in Ninjineer history and we felt good.
Then things started to go downhill. We had several bad matches, with our autonomous interrupted by our own teammate, a bunch of totes falling in the wrong position, and dropped recycling containers, and finished the day in seventh. However, one of our scouts' favorite teams, Sachem Aftershock, came into our pit and spoke with us about our autonomous and robot design, giving us hope that we still remained on the "first pick" radar.
We also won the Entrepreneurship Award thanks to the hard work and dedication of many of our members, including Asad and Pedro for writing and editing, as well as Jeni and Kristine for submission. We can now proudly say that we've won an award each year that we have submitted for awards, which is no mean feat.
Saturday: End of Quals
You have never experienced frustration until you change nothing but everything goes wrong. Our autonomous went insane starting on Saturday morning, swerving into random directions, pushing our robot off balance, and losing us countless points. We tried resetting the gyro, turning one off, replacing it etc. until we finally got it working again….. after quals ended. We were in twelfth.
Alliance selections:
In a tense moment, another team picked Sachem and we waited, worried we wouldn't get picked at all. But without a second thought, Team 263 declined and picked us, after which we, graciously, agreed to put our noodles in their bins.
Honestly, these matches are all a blur to me now. I can only speak for myself, but I feel like the victory is less real to the drive team than it is to everyone else, simply because the only way to keep your cool on the field is to focus on the moment and not think about what is actually happening. All I registered were the numbers on the screen, through quarterfinals in second place, through semis in first and down to the finals.
The buzzer sounded for the first match of the finals; the first head-to-head of the whole competition, aaaand our autonomous went completely wrong. The bin got in the way, we dropped the totes, and we began the match twenty points down. However, both we and Sachem completed our 6-tote stacks with noodles and bins and with a little help from the Voltage human player, we won the match with a discernible lead (despite my -probably unprecedented- coach foul for stepping into the human player box… oops.) Then, the second match went horribly wrong. The totes fell the wrong way, we dropped our trash can, and we lost by more than 20 points.
Down to the last match, as I suppose it should be. Our compressor finishing just in time, we hustled off the field for our last match of the South Florida Regional. Our autonomous functioned perfectly, we grabbed the trash can in mere seconds after auto, and unloaded our stack flawlessly onto the scoring platform only to realize our alliance captains had lost their trash can. We frantically stacked 3 more in an attempt to compensate and unloaded onto the scoring platform, 386 accidentally pushed them off, we pushed them back, and buzzer.
I quickly scanned the field and saw two stacks with trash cans on the opposite side. I had that sinking feeling in my gut- not again, not again- preparing myself for the pep talk, and slowly accepting my fate. But I still had a tiny glimmer of hope: until they flashed those numbers on the screen our fate wasn't sealed. And there they were: 100 in a little blue box, and a 104 in the red one, the most beautiful numbers I have ever seen.
I distinctly remember turning around, still processing the numbers when I saw Damian understand what had just happened and jump 3 feet. The next few hours were a blur of laughter, tears, hugs, and camera flashes mixed with a healthy mixture of euphoria and disbelief.
I am so incredibly proud of my team, my fellow seniors (WE DID IT), and all of the hard work and passion that has led to this moment.
As Amy Zhou wisely said on Wednesday night, "'Tis a year of many 'firsts'."
So we keep making progress! Everyone is working hard on CAD-ing and machining all necessary parts for our practice and final robot.We are continually assembling the bot as the pieces come out and things are looking really good. We'll start practicing extensively very soon to work out any kinks and cement our game strategy.
We're also starting to plan our regionals and attendees. I can't believe this is the last year of awards, rosters, and rooms… everything feels so final.
Notable accomplishment of the week award goes to our Java team who got the robot to move on their java code for the first time ever. Shout out to Eric and Manusri who have put in a lot of hard work to accomplish this.
Damian has been out sick for 2 days now, but should be back again tomorrow :). The scouting spreadsheet looks better everyday as Asad and Damian make more and more improvements. As soon as Damian is satisfied (sometime this year, I swear), we'll release the spreadsheet on Chief Delphi for everyone to use.
Now, I need to catch up on sleep. 🙂
So, with design finalized, we enter into the CADing/Machining period. Prajesh and the mechanical team work throughout their independent periods to finish the robot CAD as fast as possible, but still maintain all measurements exact. We plan on starting machining tomorrow for the chassis. The Chassis this year will sport a 4 mini cim mecanum drive using Toughbox Nano gearboxes. Gooby tested the use of a gyro on the robot to help control mecanum drive, and the results were swerve like. All we need to work on is balancing weight and mounting encoders to ensure mecanum is practically flawless. Aside from that, the scouting spreadsheet (my baby) is about half way done. Asad and I completed the first spreadsheet which is for scouts to collect data. The second spreadsheet will be the master one that will compile all the data and output it for the head-scout to read in an ordered fashion.
In case you missed our week 3 teaser video, here is is
Welcome to week 4!
Today our major shipments from AndyMark came in, and it was like Christmas… expect with controllers, tubing, and metal. Along with all this came our GIANT tanks for pneumatics that took forever for UPS to deliver. Luckily these tanks don't hurt us on weight too much.
For mecanum drive, we swapped out our AndyMark wheels for the new Vex Pro mecanum, and it seems to be smoother and also they weigh less which is a big plus in the scheme of things. Strafing has been better this year compared to other years, but with the knowledge our team now has, we should be able to correct it using encoders and also properly distributing weight.
The practice bot is basically done, and now our CAD team is working to create everything and make it clean cut, and hopefully we can paint this year.
The none robot side of team has a ton of stuff, from awards, to the scouting spreadsheet, and lastly a special video project by team management. I have been very focus on the spreadsheet to make it as user friendly as possible without diminishing data quality. Once we have it done along with a small instruction manual, any team should be able to use it with relative ease.
Build season is shaping up, and having a week one event will be a new experience and we will learn a lot early on in the season.
Pretty pumped,
As far as robot progress goes, we are basically set in all aspects of the design. As for any robotics team, there will be tons of tweaking until everything is perfect for optimal movement and stacking ability. Luckily we don't have school on Friday or Monday this week, so those long days will really help get everything rolling into the final production line.
In terms of strategy, I was debating how the game would be played and I sent a tweet to Karthik K (an avid FRC Robotics strategist). His main message was that he thinks the game would be played in a a "Divide and Conquer" style, which basically means an alliance partitioning the field so every robot can score effectively and not be in the other robots way. Knowing how rules change and new ideas arise, this strategy may change, but for our week one event in Fort Lauderdale, this seems like a solid plan.
All in all, our robot is shaping up, team morals are high, and I think I can say for the most part, we are excited about Recycle Rush.
And thus ends our most successful season ever.
Oh, and welcome to our new team blog. Here you will find updates on everything going on in room 7110 at American Heritage School. That's our home (for six weeks at least) where we design, build, and program a professional robot while maintaing seven classes, the SAT, AP exams, sports, clubs, and whatever else high school students have to deal with. That's right, we're high school students. We are team 2383, the Ninjineers, of the FIRST Robotics Competition (FRC). Each year we spread the message of FIRST and compete for an opportunity to go to the FRC World Championships.
And this year, we made it.
Our team began in 2008 here at American Heritage School. It was a humble beginning, with just a few students and teachers guiding the team. Eventually we moved into the bus shop at the far end of our campus where we continued working year after year. Since then, our team has grown incredibly. Our school now houses us in a state of the art facility where we work tirelessly. Many of our students participate in the Pre-Engineering Program which educates students in engineering, physics, and architecture featuring classes administered with certified Project Lead the Way curriculum. Additionally, the growing Pre Bio-Medical Engineering program has bridged the gap between with our school's Pre-Medical track. In the past decade, the presence of engineering has exploded at American Heritage, and we plan to continue the growth for years to come.
But it's not all about engineering. In our club, students can participate in management and public relations efforts, learning essentials to business and communications.
When we found out we would be attending the 2013 FRC World Championships in St. Louis, it came suddenly to all of us. It was Tuesday, April 16th, and students were in their final class of the day, taking exams, writing notes, and doing all the usual activities. We had since completed our regional competitions without securing a spot in St. Louis. Our slightly crazed mentor had been continually checking his e-mail for weeks, holding onto a glimmer of hope. You see, last October we applied for a waitlist for the World Championships. Just in case. But with the championship just a week away, many have given up this hope. But, the e-mail came. It actually came. With just one week to organize all school assignments, ship our robot and tools, notify students, and do everything else needed to travel across the country, we scrambled to get ready for this amazing opportunity. On the next Tuesday after school, about 20 students gathered at Ft. Lauderdale-Hollywood International Airport and departed for an awesome week.
The whole experience was slightly surreal, hard to even believe. Some teams we talked to had a surprised look to see that we had made it. But we had, and we were determined to make some noise on the world stage. A few early blunders and close matches led us to losing four of our first five matches. But, we remained determined and won our last three matches by margins of 41, 58, and 72 points. Our future lay out of our control, as we entered alliance selections, hoping to be selected.
Our talent was our versatility. This year's FRC game featured two totally different objectives: shooting Frisbees into rectangular goals and climbing a 7 and 1/2 foot tall runged pyramid. The unique challenge led to many diverse designs across the competition. Some ran their robot continually between the feeder stations and goals, shooting many cycles of disks. Others camped out at the feeder station and shot disks across the 54-foot field. Some focused on innovative climbing methods, reaching the top of the pyramid quickly and efficiently. Our robot, however, accomplished both game challenges. We cycled disks into the goals and climbed efficiently to the top of the pyramid.
At the South Florida Regional, we proved to be the only robot all weekend that climbed all the way up the pyramid. Not only did we accomplish this task, but we did it consistently, in almost every match. This versatile climber along with our shooting abilities convinced the judges to award us the Excellence in Engineering Award sponsored by Delphi for our "King Kong" like climbing design.
However, at our first competition of the year, our climber wasn't as prime for competition. In fact, we only reached the top once. And it was quite the exciting climb. From the driver station, our drivers see the back of the robot as it climbs. The main hook is completely obstructed by the main column of the robot. So, when we finally achieved our top climb, little did we know how fragile this climb really was. But close enough is enough sometimes. We got the top climb.
So, with alliance selections looming in St. Louis, we were heartbroken as our team was not selected. It was a sad end to our best season ever. But sometimes, close enough is enough. We tried our hardest on the world stage. We ended up as tied for 2nd best among all the Florida teams that attended in St. Louis and we were one of the best climbers in the whole competition. We had an incredible year and had so much fun along the way. Our success is not measured only in rankings or awards, but in how much we've all grown this year. We've learned incredible skills and grown closer as friends and peers.
This is an incredible program and we hope you follow along here as we do bigger and better things in the future. Thanks for reading. Check back often.


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Jewish World Review March 28, 2001 / 4 Nissan, 5761
Workstyle by Paula Bern
http://www.jewishworldreview.com -- Q: We recently moved into a bedroom community near our company headquarters. Because of its proximity to the workplace, three other couples have bought homes here, too. The problem is that they all have youngsters in Brownies, Cub Scouts, Girl Scouts and/or Little league. (I'm sure there are a few groups I've overlooked here, but you get the idea.) At one time or another all of them are selling cookies, candy bars or other such stuff to benefit their troop or team. There are weekends when it is a steady parade of kids at my door, each kid lugging merchandise. I don't want six boxes of mint cookies and four chocolate almond bars. I do have to work alongside the parents and I don't want to be thought of a Scrooge. But how can I cut back (and lose a few pounds in the process) by not feeling compelled to buy? -Eleanor, Jackson, Mich.
A: Take a stand and not give in to the children's pleas. You're not going to buy their parents' friendship or goodwill at the office by loading up on Girl Scout cookies. If you truly don't want what the youngsters are selling, just tell them that while you enjoy seeing them, the merchandise isn't something that you want or need. Of course you don't want to hurt their feelings, but life does have its disappointments and you can't solve them this way.
Q: I have two small children and would like to work from home rather than take an office job. A friend suggested I look into a job as a systems analyst but I have absolutely no idea what this might entail. The person said this might be ideal at this time of my life. Have you any recommendation? -Emma, Monkton, Md.
A: I don't have any hints as to your pre-kids work background, but I can tell you a job such as this requires considerable knowledge about both business and technology. As a system analyst you would have to come up with methods, using computers and software, to make a company run more efficiently. You would have to understand the company's overall business strategy and work closely with management before choosing the right system or recommending software packages. You probably would work on a contract basis and earn between $35 to $150 an hour, depending on the project. A degree in information systems would be helpful.
With this sort of position, you have fairly strong control over your hours. And Priscilla Claman, president of Career Strategies in Boston, says system analysts at the entry level can earn about $47,000 a year.
Q: What is the protocol for helping yourself to candies sitting on a barber's shelf? I recently started going to a unisex barber shop and it's usually on my lunch hour, which means I'm starving. The barber never says, "Have one," but he sucks on a butterscotch the whole time I'm there. The dish of hard candies is on his back shelf, alongside his sprays, hair gels and men's cologne. It may be that the guy keeps them there as a part of his personal stock. Would it be OK to ask for one or should I just keep my mouth shut? -Jim, King of Prussia, Pa.
A: If you're that hungry when you go for a haircut it might be
simpler to take along a sandwich and a piece of fruit. I would tend
to suspect that you'd be correct in assuming that they are his
candies, which he keeps on his private shelf. Otherwise, I suspect
they'd be placed more toward the customers
03/22/01: Express lane miscreant ... wife needs a life
Dr. Paula Bern has taught executive seminars at Carnegie-Mellon University. Comment by clicking here.


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YUCCA VALLEY — The Joshua Springs Christian School cheerleading team is rebuilding and looking at the possibility of competitions this year, head coach Keersten Milson said.
There are four new members to the team, which has six in total.
The team captains this year are Katie Dimoff and Shaina Landers.
The girls are hard at work practicing every day, sometimes twice a day, getting prepared for the upcoming football and basketball seasons.
"There are 65 cheers for just football alone that the girls have to learn," Milson said.
The squad members have been doing at least 30 minutes of conditioning each practice and then working on their dances as well as their stunts.
click here to read more.


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A business owner in an upscale North Toronto neighbourhood says he doesn't feel safe in the area any more after witnessing a brazen fatal shooting on Tuesday night.
The man, who did not want his identity or business revealed for fear that it may affect his livelihood, said he heard "four or five" gunshots about 9:20 p.m. and saw two men run south along Yonge Street.
"It all happened in a matter of seconds," said the man, who has been in the affluent Yonge Street and Lawrence Avenue neighbourhood for 20 years. "I had customers … and they ran [into the back] and laid down on the floor."
After the initial shock of hearing gunfire, the owner told a friend to call the police while he went off to chase the shooters.
"I got in my car to try to catch them or see them," he said. "But after I made a U-turn, they were gone."
He said the men were wearing jackets with hoods and black masks underneath.
Paramedics performed CPR on a male victim as he lay between two parked cars in front of a restaurant near Yonge Street and Deloraine Avenue.
The man was transported to hospital, but was declared dead shortly after arrival. A postmortem examination was to be performed.
The victim has been identified as Peter Nguyen, 26, of Toronto. Constable Sarah Diamond said he was known to the police.
Asked whether investigators believe that Mr. Nguyen had been targeted, Constable Diamond said: "We don't have that information."
Police are searching for two male suspects who fled the area on foot and were spotted heading west on Melrose Avenue.
The gunfire erupted in a neighbourhood more known for its upmarket shops, restaurants and real estate than violent crime.
Steps away from the site of the shooting, a home is listed for sale at just under $2-million and a fourplex mansion is priced at nearly $3.8-million.
"This is a very good area with million-dollar houses; it could have happened anywhere," the businessman said.
"I consider this a top area in the city, but lately the whole city has become an unsafe place."


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Fujian Provincial Cancer Hospital
Fujian Provincial Cancer Hospital
Shi P.,Fujian Normal University |
Zhong J.,Fujian Provincial Cancer Hospital |
Huang R.,Fujian Provincial Cancer Hospital |
Lin J.,Fujian Provincial Cancer Hospital
Proceedings - 2016 8th International Conference on Information Technology in Medicine and Education, ITME 2016 | Year: 2017
The microscopic image of tissue section stained by hematoxylin-eosin (HE) is an essential part in histopathology researches. Automated HE image processing remains challenging because forms and distributions of cells and other tissue structures are always extremely irregular with no clear boundaries, especially in conducting high throughput analysis which demands higher accuracy and efficient quantification for the reference of pathologists. To solve this problem, we proposed an automated quantitative image analysis pipeline based on hierarchical clustering of local correlations, which segmented the image into nuclei, cytoplasm and extracellular spaces by classifying image pixels on the basis of local correlation features. Segmentation for precise nucleus boundaries was then performed, and finally a set of indicators characterizing tissue structures were extracted to complete quantification of HE images. Experimental results showed high accuracy and adaptability in cell segmentation despite data variance. Quantitative indicators obtained in this essay provide a reliable evidence for the analysis of HE staining lymphoma pathological image. © 2016 IEEE.
Lin D.,Fujian Normal University |
Lin D.,Fujian University of Traditional Chinese Medicine |
Pan J.,Fujian Provincial Cancer Hospital |
Huang H.,Fujian University of Traditional Chinese Medicine |
And 7 more authors.
Scientific Reports | Year: 2014
This study aims to evaluate the feasibility of a label-free nanobiosensor based on blood plasma surface-enhanced Raman spectroscopy (SERS) method for exploring variability of different tumor (T) stages in nasopharyngeal cancer (NPC). Au nanoparticles as the SERS-active nanostructures were directly mixed with human blood plasma to enhance the Raman scattering signals. High quality SERS spectra can be acquired from blood plasma samples belong to 60 healthy volunteers, 25 NPC patients with T1 stage and 75 NPC patients with T2-T4 stage. A diagnostic accuracy of 83.5% and 93.3%, respectively, can be achieved for classification between early T (T1) stage cancer and normal; and advanced T (T2-T4) stage cancer and normal blood groups. This exploratory study demonstrates that the nanobiosensor based on SERS technique in conjunction with PCA-LDA has great potential as a clinical complement for different T stages detection in nasopharyngeal cancer.
Lin C.,Fujian Medical University |
Chen X.,Fujian Medical University |
Li M.,Fujian Provincial Cancer Hospital |
Liu J.,Fujian Medical University |
And 6 more authors.
Clinical Lung Cancer | Year: 2015
Background The immune checkpoint proteins programmed death-1/ligand (PD-1/PD-L1) play a critical role in immune escape of tumor cells. In models of epidermal growth factor receptor (EGFR)-driven non-small-cell lung cancer (NSCLC), EGFR signal upregulates PD-1/PD-L1. However, data on the clinical significance of PD1/PD-L1 expression in patients with the subtype of NSCLC carrying EGFR mutations remain limited. Materials and Methods Immunohistochemistry was performed to evaluate the expression of PD-1, PD-L1, and CD4+ and CD8+ tumor-infiltrating T lymphocytes (TILs). Results In a cohort of 56 patients, PD-L1 and PD-1 was positive in 53.6% and 32.1% of tumor specimens, respectively. PD-L1+ patients had a significantly greater disease-control rate (P =.004), in association with longer progression-free survival (P =.001) after EGFR-tyrosine kinase inhibitor (TKI) therapy and overall survival (P =.004), and no correlation between PD-1 positivity and clinical outcomes was observed. PD-L1 expression was not significantly associated with either clinicopathologic features or TILs. Conclusions These findings suggest that this subtype of EGFR mutation-positive NSCLC is highly eligible for PD-1/PD-L1 immunotherapy. PD-L1 might represent a favorable biomarker candidate for the response to EGFR-TKIs and outcomes of these patients with NSCLC. © 2015 Elsevier Inc.
Wu C.,Peking Union Medical College |
Miao X.,Huazhong University of Science and Technology |
Huang L.,Peking Union Medical College |
Che X.,Chinese Academy of Sciences |
And 34 more authors.
Nature Genetics | Year: 2012
Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10 -13 to P = 4.18 × 10 -10) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer.
Zheng P.-C.,Fujian Medical University |
Chen X.,Fuzhou General Hospital of Nanjing Military Command |
Zhu H.-W.,General Hospital of Guangzhou Military Command |
Zheng W.,Fujian Provincial Cancer Hospital |
And 4 more authors.
Cancer Science | Year: 2014
Calpain small subunit 1 (Capn4) plays a key role in tumor migration or invasion. In this study, expression and function of Capn4 was investigated in human nasopharyngeal carcinoma (NPC). Here we report that both mRNA and protein levels of Capn4 were elevated in NPC tissues when compared to normal NP tissues. Similarly, Capn4 was also highly expressed in multiple NPC cell lines, compared to immortalized human nasopharyngeal epithelial cell line NP69. Moreover, expression of Capn4 was significantly correlated with Epstein-Barr virus infection, advanced stages, and lymph node or distant metastasis (P < 0.001). The patients with NPC displaying higher Capn4 had a significantly shorter overall survival (P = 0.002) and progression-free survival (P = 0.003). Furthermore, siRNA knockdown of Capn4 suppressed cell migration and invasion in vitro and in vivo. These events resulted from Capn4 downregulation were associated with reduced expression of matrix metalloproteinase 2 (MMP2), Snail, and Vimentin. Finally, we demonstrated that Capn4 upregulated MMP2 via nuclear factor-κB (NF-κB) activation, manifested by increased phosphorylation of p65, a subunit of NF-κB. Together, these findings argue a novel function of Capn4 in invasion and metastasis of NPC, and thereby suggest that Capn4 may represent an independent prognostic factor and a potential therapeutic target in NPC. Capn4 is a marker of poor clinical outcomes that promotes nasopharyngeal carcinoma metastasis via NF-kB induced MMP2 expression. © 2014 The Authors.
Wu S.-X.,Sun Yat Sen University |
Cui T.-T.,Sun Yat Sen University |
Zhao C.,Sun Yat Sen University |
Pan J.-J.,Fujian Provincial Cancer Hospital |
And 3 more authors.
Radiotherapy and Oncology | Year: 2010
Purpose: A multi-center prospective randomized trial was conducted to evaluate the efficacy and safety of Actovegin in the prevention and treatment of chemoradiotherapy-induced acute oral mucositis. Methods and materials: Between February 2006 and May 2007, 156 evaluable patients with nasopharyngeal carcinoma were randomized to Group 1 (n = 53) for prevention, Group 2 (n = 51) for treatment, and Group 3 (n = 52) for control. All patients received concomitant chemoradiotherapy ± induction chemotherapy. Radiation technique and dose were similar among 3 groups. Intravenous Actovegin of 30 ml daily (5 days/week) was administrated from day 1 of the radiotherapy for Group 1 and from the onset of grade 2 mucositis for Group 2, until the end of the radiotherapy. Results: The incidence of grade 3 mucositis was lower in Group 1 compared with Group 3 (26.4% vs. 55.8%, P = 0.002). Group 2 had a lower progression rate of mucositis from grade 2 to 3 compared with Group 3 (39.2% vs. 60.4%, P = 0.035). There was no difference in the onset time of grade 3 mucositis among 3 groups. Actovegin was well tolerated and no treatment-related adverse events were observed. Conclusions: Actovegin is effective in the prevention and treatment of chemoradiotherapy-induced oral mucositis. © 2010 Elsevier Ireland Ltd. All rights reserved.
Zheng D.,Fujian Medical University |
Chen Y.,Fujian Medical University |
Chen Y.,Fujian Provincial Cancer Hospital |
Xu L.,Fujian Provincial Cancer Hospital |
And 5 more authors.
Journal of Magnetic Resonance Imaging | Year: 2014
Purpose To evaluate the relationship between quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and clinical stage of nasopharyngeal carcinoma (NPC). Materials and Methods Fifty-one newly diagnosed NPC patients received MRI examination on Philips Achieva 3.0 Tesla TX MR system. We used DCE-Tool (Philips Healthcare, Best, The Netherlands) to investigate parameters from primary tumors. Tumor/node/metastasis and corresponding clinical stages were determined based on 2009 UICC 7th edition. The correlations between quantitative parameters and clinical stage were correlated using Pearson correlation analysis. Results Mean Ktrans, Kep, ve, and vp for primary tumors were 0.500 ± 0.188/min, 0.744 ± 0.273/min, 0.986 ± 0.595, and 0.052 ± 0.071, respectively. Both Ktrans and Kep of tumors showed moderate negative correlation with clinical stage, T stage and N stage (P < 0.05), while ve showed moderate positive correlation with them (P < 0.05). vp revealed a moderate negative correlation with T stage (r = -0.369; P < 0.004). Kep and ve have significant differences between many early and advanced stages patients. Conclusion DCE-MRI is feasible to assess vascular permeability of NPC patients. Our results first revealed that the quantitative parameters were significantly related to clinical stage of NPC. Thus, DCE-MRI may be valuable to add noninvasive prognostic indicators in evaluating NPC. © 2013 Wiley Periodicals, Inc.
Lin X.,Mount Sinai School of Medicine |
Lin X.,Fujian Provincial Cancer Hospital |
Zhao Y.,Mount Sinai School of Medicine |
Song W.-M.,Mount Sinai School of Medicine |
Zhang B.,Mount Sinai School of Medicine
Computational and Structural Biotechnology Journal | Year: 2015
Gastric cancer, a highly heterogeneous disease, is the second leading cause of cancer death and the fourth most common cancer globally, with East Asia accounting for more than half of cases annually. Alongside TNM staging, gastric cancer clinic has two well-recognized classification systems, the Lauren classification that subdivides gastric adenocarcinoma into intestinal and diffuse types and the alternative World Health Organization system that divides gastric cancer into papillary, tubular, mucinous (colloid), and poorly cohesive carcinomas. Both classification systems enable a better understanding of the histogenesis and the biology of gastric cancer yet have a limited clinical utility in guiding patient therapy due to the molecular heterogeneity of gastric cancer. Unprecedented whole-genome-scale data have been catalyzing and advancing the molecular subtyping approach. Here we cataloged and compared those published gene expression profiling signatures in gastric cancer. We summarized recent integrated genomic characterization of gastric cancer based on additional data of somatic mutation, chromosomal instability, EBV virus infection, and DNA methylation. We identified the consensus patterns across these signatures and identified the underlying molecular pathways and biological functions. The identification of molecular subtyping of gastric adenocarcinoma and the development of integrated genomics approaches for clinical applications such as prediction of clinical intervening emerge as an essential phase toward personalized medicine in treating gastric cancer. © 2015 Lin et al.
Huang R.-F.,Fujian Provincial Cancer Hospital
Chinese Journal of Pathology | Year: 2011
Objective: To study clinicopathologic and genetic features of anaplastic lymphoma kinase ( ALK )-positive large B-cell lymphoma (LBCL). Methods Light microscopy, EliVision immunohistocheimical method and fluorescence in-situ hybridization were used to evaluate three ALK + LBCL cases recently diagnosed accompanied with a literature review. Results All three cases were male adult patients (mean age =36.3 years) with nodal involvement by lymphoma. Histologic evaluation revealed a diffuse effacement of the nodal architecture by the infiltration of tumor cells. Sinusoidal infiltration was seen. The neoplastic cells were large and exhibited the immunoblastic/plasmablastic morphology. By immunohistochemistry, all the cases showed a cytoplasmic granular staining of ALK. They were positive for CD45, CD138, and epithelial membrane antigen (EMA) , but were negative for CD3, CD20, CD79a and CD30. Fluorescence in situ hybridization (FISH) demonstrated the presence of ALK gene translocation in all of the cases. Conclusions ALK + LBCL represents a distinct variant of diffuse large B-cell lymphoma, usually involving lymph node of middle-aged men. The tumor has a immunoblastic/plasmablastic morphology along with a distinct immunophenotypic profile and ALK gene rearrangement.
PubMed | Fujian Provincial Cancer Hospital
Type: | Journal: Medical science monitor : international medical journal of experimental and clinical research | Year: 2017
BACKGROUND The aims of this study were to analyze the prognostic value of baseline lactate dehydrogenase (LDH) among nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT), and to evaluate the potential application of LDH in monitoring treatment efficacy dynamically. MATERIAL AND METHODS From June 2005 to December 2010, 1188 patients with non-metastatic NPC who underwent IMRT with or without chemotherapy were reviewed. Univariate and multivariate analyses were performed to evaluate the predictive value of baseline LDH. Wilcoxon signed-rank test was used to analyze the difference between baseline and post-radiotherapy LDH, and to compare post-radiotherapy LDH with the LDH in cases of distant failure. RESULTS Patients with elevated LDH had significant inferior survival rates, in terms of overall survival (70.0% vs. 83.2%, p=0.010), disease-specific survival (71.1% vs. 85.7%, p=0.002), and distant metastasis-free survival (71.1% vs. 83.4%, p=0.009), but not correlated with locoregional relapse-free survival (p=0.275) or progression-free survival (p=0.104). Subgroup analysis demonstrated that this predictive effect was more significant with advanced stage. Sixty-five post-radiotherapy LDH levels were available from the 90 patients with high LDH at initial diagnosis, and these levels fell in 65 patients, with 62 cases (95.4%) falling within the normal range. Of the 208 patients who experienced distant metastasis, 87 had an available LDH level at that time. Among them, 69 cases (79.3%) had an increased level compared with the post-radiotherapy LDH level. CONCLUSIONS Pretreatment LDH is a simple, cost-effective biomarker that could predict survival rates and might be used in individualized treatment. It is also a potential biomarker that might reflect tumor burden and be used to monitor therapy efficacy.


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Excited New York City Tourist Gets Put in Her Place in the Most New York City Way
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Victoria brings the snowbirds in the winter time, and according to a publication aimed at planners of conventions and events, it's the number one spot in the south for those kind of events...
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So if the Chamber blows out the "Bring Your Boots" slogan, which it almost certainly is going to, what now?