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Dr. Janice Dutcher, MD is Professor of Medicine at New York Medical College and Associate Director for Clinical Affairs at Our Lady of Mercy Cancer Center, Bronx, NY. She is a founding member of the Cytokine Working Group and served as Chair of the FDA Oncologic Drug Advisory Committee. She is actively involved in patient care and clinical research in renal cell cancer, and is a strong advocate for research into the etiology and treatment of RCC.
I jotted down 5 conclusions the Cytokine Working Group had drawn from the study:
The response rates were 25% for high dose Interleukin-2 vs. 11% for low dose sub q administered IL-2 plus Interferon alpha. The conclusion was that high dose Il-2 should remain the preferred method of treatment where minimum patient performance standards are met. This is a statistically significant difference in response rate. She gave median response durations of 16 months for the high dose and 13 months for the low dose but these are not statistically different.
Dr. Dutcher indicated that the significance of this study was that it is the first true randomized study where patient selection does not influence the data. The only other true random study is a NIH 3-arm study.
She indicated that the response rate approaches 40% in lung-only metastasis with high dose IL-2. Anecdotally, she feels prolonged itching as a result of treatment correlates to a response. She also indicated that each successive cycle of high dose IL-2 gets more difficult for the patient, as the body "remembers", receptors are primed to the IL-2 and respond faster and more vigorously each time.
Responding to a question, she indicated she is aware of no scientific data on a thyroid auto-immune response associated with response to IL-2. There has been anecdotal discussion here on the list suggesting a link.
One final interesting insight she gave, was that data shows that biologic therapies prolong survival even if no objective response is seen. I took this to mean that though the tumors might not shrink substantially, disease progression is slowed.


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subset: commoncrawl


text:
Challenge accepted Wendy's
June 7, 2015
More photos
The dark side of
You shouldn't stand close to moving
Who wore it
Expect record highs over the
House Fishing in
Today is my last day at work so my coworker decided to leave me a
Reddit in a
Clearly, a stupid
My 6yo said she had the bakery write something special on my birthday cake. She did NOT
What a righteous
Jennifer Lawrence on her "joke" collection of
Girlfriend stayed over for the first time last night. It has
Life is like a box of
I would hope
Testing out a new bullet proof
Almost every Netflix category is a John Stamos reference for April Fools
We all know who the greatest sniper
I'm back! wait, what! my
Our newly adopted kitten felt at home on the couch real
April Fools Day Office


text:
There are some celebrities that amaze just about everyone. It can be with their acting or even just with what they wear on a daily basis. One such star is Brad Pitt. He is seen around the world in a variety of different sunglasses that look amazing on him. Because of this fascination with him, you too can find the Brad Pitt sunglasses that only he can make this famous. One of the brands he has been sporting lately is Cazal.
These glasses have such a unique design to them that just makes them look expensive. You can be the talk of the town in this brand.
Another one of the more popular Brad Pitt sunglasses is by Marc Jacobs. Not only does Marc Jacobs know how to do clothes, he also make eyewear look amazing. You will look so completely sophisticated in any of the glasses in Marc Jacobs' line. He was seen wearing the 215 model from the current line. They are the perfect example of what oversized sunglasses should look like.
If you need more ideas for his sunglasses, look no further than Burberry. This is such a stylish designer, that the sunglasses are sure to look great. Brad has been seen wearing the 3022 model, which is a unique take on the classic aviator.
Brad Pitt also loves the Tom Ford design. This line really is a staple when it comes to wearing what the celebs wear. Just about anyone who is anyone in Hollywood has a Tom Ford. To look more like Brad, check out the Hunter line. He also has been seen wearing the Bailey and the John. If you are looking for Brad Pitt sunglasses, you really do not need to look anywhere but Tom Ford. He has been seen wearing so many different models in the line that you can pick any Tom Ford look and still look like Brad Pitt.
Because sunglasses are such a staple in Brad's wardrobe, it is no wonder that so many people want to wear what he wears. Visit the Web site Sunglasses Avenue to find your favorite Brad Pitt look.


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Dentist Weston, FL
34 results for Dentist in Weston, FL
- Stephen J Pyle DDS2239 N. Commerce Parkway33326 Weston, FL 9548947953Closed
... dentistry while employing state-of-the-art technology since opening his office in Weston in 1986. If you're looking for a Weston Dentist we're an experienced and caring practice you can trust.
- Unique Dental Care2701 Executive Park Drive33331 Weston, FL BROWARD (954) 651-9311Closed
We provide excellence in general dental care. Your diagnostic information is collected and studied. A treatment plan is presented, informing you what is needed, why, how long it takes and how much it ... dentistry, dental, dentist
- Smiles By Design: John Garcia, DDS4450 Weston Road33331 Weston, FL (954) 210-7017Closed
... Complete Dentistry, both of which he now follows. Dr. Garcia has been in private practice as a dentist since 1990, and he strives to keep up with the latest advances in the dental field so he can...
- Advantage Dental Care17130 Royal Palm Blvd33326 Weston, FL BROWARD (954) 384-7505Closed
... Offices Of Dentists, Health Services, Dentists, Clinics Of Dentists, General Dentistry
- Country Isles Dental1130 Weston Rd33326 Weston, FL BROWARD (954) 384-8222Closed
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- Jeffrey P. Heilig, DMD Pediatric Dentistry1040 WESTON RD # 30033326 Weston, FL (954) 384-8888Closed
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- Leana Thanos DDS1625 N Commerce Pkwy33326 Weston, FL BROWARD (954) 389-8887Closed
The team at Thanos Dental Care in Weston is committed to providing the highest quality patient care in a family friendly and comfortable atmosphere. As we improve smiles, we continue to strive to...
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Nutrition is at the root of metabolic changes that instigate and maintain cancer. This webinar will provide a comprehensive overview of nutritional approaches to modulating mitochondria, stem cells, cancer cells and tumour behaviour....
The Drug Quality and Security Act, or DQSA, gave the FDA increased authority over compounding pharmacies, and the agency has responded by trying to regulate compounded drugs and supplements out of existence. Access to these compounded drugs is a life-and-death issue for...
There have been reports in the literature on the effectiveness of chelation therapy with the sodium salts of edathamil (ethylenediaminetetraacetic acid EDTA) in the treatment of scleroderma and calcinosis cutis. The intravenous use of the...
Dr. Lora Fulp Efaw is a board-certified family physician who provides primary care and integrative medicine for family members of all ages. Services include management of chronic diseases; routine gynecology; complete physical exams; the ordering and interpreting of tests;...
Increasingly, human kidneys are under assault from environmental toxins as well as an array of diseases that place them at risk of ultimately failing. Eleven percent of American adults now show evidence of chronic...
These common mistakes can undermine all the creativity and energy you put into your online marketing. Identify them, and avoid them. Innovative healthcare marketing takes time, creativity, and dedication—and recognition of the potential missteps along the way. If you...
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Photos (1)
The Pride of Brasilia
Some will say that Brasilia is a sleepy town, after living there for two years, I choose to believe that it is an outdoorsy town with sparks of excitement in just the right places. At the center of the city is the Ponte JK, a harmonious piece of architecture linking the city to nature. Walk, run or cycle over the wide foot paths on either side of the bridge, paddle-board beneath it or relax from a number of parks around it during the day or in the evening with a cold drink. Each night the small park (with playground!) beneath the bridge, comes alive with vendors selling ice cream, local snacks, hot dogs and beer. Vendors set up tables beside their trucks and an impromptu party begins as if on cue as the sun begins to set each night beyond the bridge.
By Elise Hanna
Have you been here? Share a tip or a photo with fellow travelers.
Pte. JK - Brasília, DF, Brazil
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Natural Resources Manager jobs
Paramount Recruitment01 Nov
Scientific Director
A Scientific Director is required for a highly successful and leading medical communications group to join their talented team in Oxford. You...
Paramount Recruitment01 Nov
Scientific Director – Macclesfield
A Scientific Director is required for a highly successful and leading medical communications group to join their talented team in Macclesfield...
Paramount Recruitment19 Oct
Team Leader – Life Sciences – 12 Month Contract
...suited. Keywords: Team Leader, Team Leader, Manager , Marketing, Biotechnology, Biotech, Science, Life Sciences, Product Manager , Laboratory Manager...
Harris Garrard Academy09 Nov
KS1/KS2 Phase Leader
We are looking for qualified, experienced and inspirational teachers to join our school as Phase Leaders, leading KS1 or KS2 as part of our...
London (Thamesmead)
Cambridge Assessment08 Nov
Assessment Manager, Science (Chemistry Specialism)
Vacancy AdvertJob Title: Assessment Manager , Science (Chemistry specialism)Contract: Full-time, PermanentSalary: £37,800 - £43,000Location...
Gamble Aware24 Oct
Research Manager
...that they need quickly and effectively. As our Research Manager you will play an important role in achieving this aim by providing the evidence needed...
London (City Of London)
Paramount Recruitment02 Oct
Principal Scientist – Research Analytics
...Keywords: Data Scientist, Data Science, Machine Learning, Image Analytics, Image Analysis, Data Mining, Deep Learning, Natural Language Processing...
Evolution Recruitment Solutions16 Nov
Data Science Manager- London - 65,000 - 75,000 + Bonus
Master's or PhD degree in statistics or similar Stakeholder relations Business exposure and technical expertise in developing and operationalizing...
Modis International14 Nov
Release and Environment Manager
Modis is urgently seeking a Release and Environment Manager for an initial 6 month contract with an immediate start.The successful Release...
Leicester, Grantham, Chesterfield
Zorba Consulting Ltd20 Nov
Research Manager (Retails, FMCG, IT)
Research Manager required for an award-winning company based in Leeds. The company have grown progressively, and their client base is increasing...
Leeds, West Yorkshire
Michael Page07 Aug
Portfolio Manager - Energy & Natural Resources Portfolio Manager - Energy & Natural Resources
As a Portfolio Manager - Energy & Natural Resources in London, you will be expected to:Manage the Energy portfolio, assessing and being...
London (City Of London)
Michael Page26 Sep
Audit Senior Manager - Energy / Natural Resources Sector Audit Senior Manager - Energy / Natural Resources Sector
...The Audit Senior Manager will be a senior member of the audit group, responsible for servicing clients, directing all assurance services...
Michael Page22 Sep
Tax Manager: Natural Resources Sector £80,000 + Package Tax Manager: In-House Advisory, New Role
As well as being responsible for a wide range of taxes, including international / corporate tax, transfer pricing and indirect taxes, the role...
Network Scientific21 Nov
Terrestrial Ecotoxicology Study Director
Our client is a globally leading environmental testing company with a reputation for delivering high quality testing and regulatory advice...
North Yorkshire


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This season and your look gets better definition with just a little attention to detail. create a smoldering impact by this off white and salmon color pure georgette and net patiala style punjabi salwar kameez. This ravishing attire is amazingly embroidered with embroidery work, resham work, floral work, lace work and stones work. Product comes with a matching bottom and dupatta.
Style: Patiala Suit
Shipping Time: 10 - 12 Days
Occasion: Party, Reception, Ceremonial
Fabric: Net, Pure Georgette
Celebrity: N/A
Catalogue No.: 3508
Work: Embroidered, Stone, Resham, Lace, Floral
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By : Annie, Fosses, France
Colour and design is so nice...saree length is also long...!!! Overall saree is good...!!! Thanks
By : Samina, Brooklyn, USA


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UN out of desire to save Orumiyeh Lake
27 June 2014 [08:15] -
United Nations resident representative to Iran Gary Lewis assured the Iranian nation and government that he will do its utmost to solve the critical situation facing Orumiyeh Lake, IRNA reported.
In a meeting with an advisor to the head of Department of Environment, he added, ?it is not the West Azarbaijan people alone that are unhappy with the issue; rather we all are sad about the problem.?
A clip comparing the lake?s current situation with that of past was released during the event, which shocked the audience.
As Orumiyeh Lake is shrinking and deserts of salt expanding, officials are trying to find ways to avert an imminent disaster and stop the salt lake from drying up.
One of the largest salt lakes in the world and classified as a Biosphere Reserve by UNESCO, Orumiyeh Lake has lost more than 60 percent of its surface over the last two decades due to drought and construction of dams over the rivers feeding it.
The disappearance of the lake could leave behind billions of tons of salt which in turn would displace millions of people and endanger the ecosystem of all surrounding areas, whose economy relies on agriculture and tourism.
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Elizabeth Weinberg
Consistently great work from Brooklyn based Elizabeth Weinberg. For those needing a bit more than is on offer on her website check out her blog for regular updates and an extensive archive.
- Meet the speakers: Dougal Wilson, Ewen Spencer, GraphicDesign& and Gal-dem
- Claire Hentschker: the artist who recreated The Shining as an interactive 3D space
- Rosanna Webster and Phoebe Henry's cinematic portrait of Cuba
- Alex Hunting's crisp editorial designs are considered and multi-layered
- Raine Allen Miller's latest ad shows kids experiencing the "side effects" of tech toys
- Colin Pantall's warm depiction of childhood and fatherhood taken over 12 years
- Parker Day's lurid colours and grotesque characters elevate identity and fantasy (NSFW)
- Paper reveals Break the Internet take two, with Nicki Minaj shot by Ellen von Unwerth
- Bea de Giacomo photographs the wonders of pregnancy
- Matthieu Lavanchy recreates food emojis "irl" for The Gourmand's tenth issue
- Introducing Broccoli, the publication "normalising cannabis use, especially for women"
- One Step Ahead: we meet Paula Scher, the trailblazing Pentagram Partner


text:
SolarWinds Server & Application Monitor allows you to monitor your hybrid IT applications and systems. Monitor Microsoft® Office 365 Exchange side by side on your on-premises Exchange server and other applications. Check, track, and report on O365 user/shared mailbox growth, users over quota, archived mailboxes, inactive mailboxes, mobile device, mailbox groups, and more. You can also monitor Microsoft portal access to help ensure you're meeting your SLAs.Advertisement
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Filesystems Software
Hot topics in Filesystems Softwarewindirstat windows xp img file gptgen wipe disk usage fuse-ext4 windows directory statistics windir fuse-ext3 tree size
Windows Directory Statistics
A disk usage statistics viewer and cleanup tool for Windows21,091 weekly downloads
Gptgen is a tool to non-destructively convert hard disks partitioned in the common, "MSDOS-style" MBR scheme (including extended partitions) to use a GUID partition table (GPT).580 weekly downloads
Ultimate Process Killer
This Tool scan current Process in computer with parent file path. you can terminate process & delete the originating file. This tool will help to delete the virus process with Parent virus file which is runing the process.515 weekly downloads
Fuse-ext2 is a multi OS FUSE module to mount ext2 and ext3 file system devices and/or images with read write support. Moved project source to github: https://github.com/alperakcan/fuse-ext2370 weekly downloads
Partclone is a project like the well-known backup utility "Partition Image" a.k.a partimage. Partclone provide utilities to back up used blocks and design for higher compatibility of the file system using supported library like e2fslibs.86 weekly downloads
Force Copy Beta v 220.127.116.11
Copy currupted files from scrached CD's Dvd's Flash Drives83 weekly downloads
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USB Memory Stick Tester is a small application designed to help testing removable storage media (such as USB memory sticks) for defects78 weekly downloads
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Partition Image is an utility to save partitions (ext2/3fs, reiserfs, fat16, fat32, hpfs, ntfs) into an image file. Only used blocks of the partition are saved, and the image can be compressed in gzip or bzip2 format. You can split the image into small f104 weekly downloads
This tool enables users to search their NTFS formatted harddrives within seconds. It uses the MFT( master file table) of NTFS to search for files very fast. Ermöglicht eine extrem schnelle Dateisuche auf NTFS formatierten Festplatten.32 weekly downloads
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This project aims to be an open-source driver for iRiver's great iFP flash portable player (www.iriver.com).31 weekly downloads
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Development moved to https://sourceforge.net/projects/ntfs-3g/59 weekly downloads
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Anime checker is a portable tool that verifies the integrity of your files. It calculates the CRC32 of your files and compares it with the one found in the filename. Useful with fansubbed animes.23 weekly downloads
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LUFS is a hybrid userspace filesystem framework supporting many "exotic" filesystems (localfs, sshfs, ftpfs, gnutellafs, locasefs, gvfs, cardfs, cefs, etc. ).7 weekly downloads
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FreeDOS Shell
Free functionally equivalent clone of the Microsoft MS-DOS Shell targeting FreeDOS primarily, but freely usable in any DOS flavor.21 weekly downloads
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myrescue Harddisc Rescue
myrescue is a program to rescue the still-readable data from a damaged harddisk. It is similiar in purpose to dd_rescue, but it tries to quickly get out of damaged areas to first handle the not yet damaged part of the disk and return later.9 weekly downloads
Fast Wipe
Fast Wipe16 weekly downloads
Webmin module for managing Posix Access Control Lists (ACLs) on files and directories.12 weekly downloads
Autorun USB Virus Finder
A simple to use tool which detects the autorun.inf file finds the associated file and process . You can delete all the process and file with one click. This will be the fastest process to remove infection from USB i.e. pendrive most probably .4 weekly downloads
Broken down into the file manager (ego) and the virtual filesystem (libferris/ferrisui). the VFS libferris is the core of the project, ego uses GTK+2 and gevas to present info from libferris and allow management using gfmv, gfcp, gfrm etc and file clip9 weekly downloads
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The OpenSSI project is a comprehensive clustering solution offering a full, highly available SSI environment for Linux. Goals for OpenSSI Clusters include availability, scalability and manageability, built from standard servers.5 weekly downloads
DFK: Duplicate File Killer
DFK: Duplicate File Killer will search a user specified directory/drive for duplicate files of any kind. It will eventually utilize image recognition for image comparison, audio matching algorhythms for sound file matching and CRC/MD5 hash testing.4 weekly downloads