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- published: 08 Jul 2009
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Jamaica (i/dʒəˈmeɪkə/) is an island country situated in the Caribbean Sea, comprising the third-largest island of the Greater Antilles. The island, 10,990 square kilometres (4,240 sq mi) in area, lies about 145 kilometres (90 mi) south of Cuba, and 191 kilometres (119 mi) west of Hispaniola, the island containing the nation-states of Haiti and the Dominican Republic. Jamaica is the fifth-largest island country in the Caribbean.
Previously inhabited by the indigenous Arawak and Taíno peoples, the island came under Spanish rule following the arrival of Christopher Columbus in 1494. Named Santiago, it remained a possession of Spain until 1655, when England (later Great Britain) conquered the island and renamed it Jamaica. Under British rule, Jamaica became a leading sugar exporter, with its plantation economy highly dependent on slaves imported from Africa, followed later by Chinese and Indian indentured labour. All slaves were fully emancipated in 1838, with independence from the United Kingdom achieved on 6 August 1962.
Ocho Rios (Spanish for "Eight Rivers") is a town in the parish of Saint Ann on the north coast of Jamaica. Just outside the city, travelers and residents can visit Columbus Park, where Columbus supposedly first came on land, and see maritime artifacts and Spanish colonial buildings.
It was once a fishing village but now caters to tourists. It is a port of call for cruise ships as well as for cargo ships loading sugar, limestone, and in the past, bauxite. Scuba diving and other water sports are offered in the town's vicinity.
The name "Ocho Rios" is a misnomer because there are not eight rivers in the area. It is most likely a British corruption of the original Spanish name "Las Chorreras" ("the waterfalls"), a name given to the village because of the nearby Dunn's River Falls.
The north coast highway from the international airport at Montego Bay to Ocho Rios has been improved since 2000 and the journey is now an hour and forty five minutes drive. On 26 August 2011, the Jamaican government announced a $21 million revitalization plan for the resort area.
Robert Nesta "Bob" Marley, OM (6 February 1945 – 11 May 1981) was a Jamaican reggae singer, songwriter, musician, and guitarist who achieved international fame and acclaim. Starting out in 1963 with the group The Wailers, he forged a distinctive songwriting and vocal style that would later resonate with audiences worldwide. The Wailers would go on to release some of the earliest reggae records with producer Lee "Scratch" Perry.
After the Wailers disbanded in 1974, Marley pursued a solo career upon his relocation to England that culminated in the release of the album Exodus in 1977, which established his worldwide reputation and produced his status as one of the world's best-selling artists of all time, with sales of more than 75 million records.Exodus stayed on the British album charts for fifty-six consecutive weeks. It included four UK hit singles: "Exodus", "Waiting in Vain", "Jamming", and "One Love". In 1978 he released the album Kaya, which included the hit singles "Is This Love" and "Satisfy My Soul".
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JAMAICA..solo una parte del mondo che c'è!
Una situación insólita se dio luego de terminado el partido entre Argentina y Jamaica: uno de los jugadores del seleccionado centroamericano buscó a Messi para sacarse una selfie, y el crack le dio el gusto.
Anfang des Jahres haben wir die HELP Jamaica! Hymne von Ephraim Juda und Ganjaman auf einem Riddim von Jr. Blender veröffentlicht... Alle Einnahmen der Single gehen direkt an den Verein HELP Jamaica!. Purchase the song @ Amazon to support Help Jamaica!: http://tinyurl.com/8sewd82 Fotos: Caterina Werner HELP Jamaica! biggest supporter base is the Reggae music scene, so it is no surprise, that two reggae singers now wrote a song in support of our organization. Ephraim Juda is a young upcoming artist from Berlin, Germany, who has just released his first album Coming Home on his own Label Urban Tree Music. From a long-term visit in the Caribbean, he knows the reality of living in a poor environment. After performing at the HELP Jamaica! Charity Festival in Osnabrück in 2010, he decided to s...
A Beleza natural de Ocho Rios é inesquecível!! Quando cheguei em Ocho Rios, pensei: "O que eu quero? Sossego!! Muito sossego". Jamaica é o paraíso da ilha tropical... Ocho Rios é um lar de belíssimas praias! Praia...de areia fina e água transparente, onde as palmeiras quase bordam a água. Tudo o que se espera de uma praia do Caribe. Confira abaixo os links para os lugares que comentei no vídeo: Link para Hotel Riu Resort: http://www.riu.com/en/Paises/jamaica/ocho-rios/clubhotel-riu-ocho-rios/ Link para Resort Gran Bahia Principe: http://www.bahia-principe.com/en/resorts-in-jamaica/resort-jamaica/ Link para Dunn's River Falls: http://www.dunnsriverfallsja.com/ Link para Dolphin Cove: http://www.dolphincoveja.com/ Informação sobre as fontes das Fotos: Fotos próprias tiradas durante a...
Quizás lo más memorable del deslucido partido entre Argentina y Jamaica por el grupo B de la Copa América fue la que la selfie que se sacó Deshorn Brown con Lionel Messi ni bien terminaron los noventa minutos. Pero el buen Deshorn no fue el único que aprovechó la oportunidad para tomar una foto con el mejor jugadore del mundo: el resto de jugadores jamaiquinos también buscara a 'Lio' en incluso hicieron cola para su selfie. Así como lo lees. En la zona de prensa, los 'reggae boys' no tuvieron roche y hicieron su ordenada cola para su respectiva instantánea con el crack del Barcelona. Pero a diferencia del 'selfie' en la cancha, que sorprendió y confunió a Messi, esta vez el argentino sí sonrió y posó alegramente. Por más insólito que parezca la situación, esta son el tipo de cosas que p...
"Yeah, man!!" Mantenha a mente e o coração abertos para Kingston. A série Poupe para Viajar mostra a cidade de Bob Marley! Bom... como a maioria já pode imaginar, o estilo musical do Reggae é o mais popular do país, imortalizado por Bob Marley e vinculado ao movimento religioso do Rastafári e é, sem dúvida, um dos maiores motivos que levam os turistas de todas as idades a visitar a Jamaica, e isto impulsiona o setor do turismo. Links de alguns locais mencionados: www.devonhousejamaica.com www.bobmarleymuseum.com www.strawberryhillhotel.com Origem das Fotos: Minhas fotos de Viagem, EXCETO: Foto Devon House: www.devonhousejamaica.com Foto Hotel Hilton: http://hilton-kingston-jamaica-hotel.booked.net/ Foto Hotel Pegasus e Terra Nova: http://www.booking.com Foto do Red Bones Café: https:/...
This video explain about top tourist attractions in Jamaica. Jamaica is an island country situated in the Caribbean Sea, comprising the third-largest island of the Greater Antilles. Negril Beach, Martha Brae River, Doctor's Cave Beach are best places to visit in Jamaica. You can visit these attractions when you are on vacation in Jamaica. photo credit: Dolphin Cove by kemorgan65 www.flickr.com/photos/92745351@N05/9195650086/ Blue Hole, Ocho Rios by Jeremy Finke www.flickr.com/photos/eknif/14454245104 Dunn's River Falls by Chris Ford www.flickr.com/photos/chrisschoenbohm/5375527558 YS Falls by Bob Thomas www.flickr.com/photos/11628368@N07/5502395827 Rainforest Bobsled Jamaica by verifex www.flickr.com/photos/verifex/6570730361 Black River Safari by Gail Frederick www.flickr.com/photos...
Ik heb deze video gemaakt met het videobewerkingsprogramma van YouTube (http://www.youtube.com/editor)
El delantero de jamaica hace foto selfie con MESSI
Si quieren mas videos siganme,estare subiendo pronto
Le meraviglie di Max a Cuba...
El delantero de jamaica hace foto selfie con MESSI
✱ 4.039 Hotels in Jamaica - Lowest Price Guarantee ► http://goo.gl/q7h2oM Travel video about destination Jamaica. Montego Bay is Jamaica's second largest city which, at the end of the 18th century, was one of the most important harbours for the island's sugar industry. The lively city centre is a mixture of both old and new with modern concrete houses located next to simple wooden huts and congested streets with numerous small shops and street traders.Close to Falmouth, there's the excitement of Martha Brae River Rafting which is an excellent way to explore this tropical paradise in which dense tropical rain forest shows off all its spectacular colours. It was here on the north coast that Christopher Columbus landed in1502 and where the Spanish were defeated by the British in a bloody bat...
Top Things to do while visiting Jamaica. Jamaica is way too big to explore in one trip, but this is a good start. If you want to make us happy... Follow these: Twitter: @ScrapTownUSA SnapChat: @ScrapTown Cyber Dust: +ScrapTV Song: Bam Bam Artist: Bunji Garlin This song is 100% theirs, not ours, we don't own shit.
Travel video about destination Jamaica. Montego Bay is Jamaica's second largest city that, at the end of the 18th century, was one of the most important harbors for the island's sugar industry. The lively city centre is a mixture of both old and new with modern concrete houses located next to simple wooden huts and congested streets with numerous small shops and street traders.Close to Falmouth, there's the excitement of Martha Brae River Rafting which is an excellent way to explore this tropical paradise, in which dense tropical rain forest shows off all its spectacular colors. It was here, on the north coast, that Christopher Columbus landed in 1502 and where the Spanish were defeated by the British in a bloody battle for sovereign control of the island.Dunn`s River Falls is the name of ...
crazy jamaican tour guide
I went to Jamaica for vacation and stayed at The Jamaica Inn in Ocho Rios. Here's a peek at my stay, head to my blog post for more pictures. http://lalamer.com/jamaica-part-one/ FOLLOW ME! ♥ My Blog: http://LalaMer.com ♥ My Instagram: http://instagram.com/marianna_hewitt ♥ My Twitter: http://twitter.com/Marianna_hewitt ♥ My Facebook: http://facebook.com/MariannaHewitt ♥ My Pinterest: http://pinterest.com/lalamarianna NOW ON SNAPCHAT: MARIANNA_HEWITT
This video explain about top tourist attractions in Jamaica. Jamaica is an island country situated in the Caribbean Sea, comprising the third-largest island of the Greater Antilles. Negril Beach, Martha Brae River, Doctor's Cave Beach are best places to visit in Jamaica. You can visit these attractions when you are on vacation in Jamaica. photo credit: Dolphin Cove by kemorgan65 www.flickr.com/photos/92745351@N05/9195650086/ Blue Hole, Ocho Rios by Jeremy Finke www.flickr.com/photos/eknif/14454245104 Dunn's River Falls by Chris Ford www.flickr.com/photos/chrisschoenbohm/5375527558 YS Falls by Bob Thomas www.flickr.com/photos/11628368@N07/5502395827 Rainforest Bobsled Jamaica by verifex www.flickr.com/photos/verifex/6570730361 Black River Safari by Gail Frederick www.flickr.com/photos...
Start exploring Jamaica with Lonely Planet's video guide to getting around, when to go and the top things to do while you're there. For more travel tips, head to https://www.lonelyplanet.com/jamaica
With an 8-hour layover in Montego Bay, I decide to see the sights. I grab a guide and head to see an old slave owner's house, then head into the city to see the hustle and bustle of the centre. Then we head up into the hills to see the giant Red Stripe sign and to get a good aerial view. Finally, I get to see some the beaches that Montego Bay is famous for.
Jamaica is one of my favorite islands in the Caribbean! From adventure activities like rafting to horseback riding on the beach and luxury hotels like Half Moon in Montego Bay to Bluefields Bay Villas there is so much to see and do! Read more about everything in The Ultimate Luxury Guide to Jamaica here: http://www.thetravelwomen.com/blog/the-ultimate-luxury-guide-to-jamaica
Jamaica Travel Video Guide: With 2.8 million people, Jamaica is the third most populous anglophone country in the Americas, after the United States and Canada. It remains a Commonwealth realm with Queen Elizabeth II as Head of State. Jamaica has a large population of Chinese and East Indians. Sizeable numbers of Whites and Mulattoes, and persons of Syrian/Lebanese descent, many of which have intermixed throughout the generations. Individuals on the island seldom belong to one racial group as mixed-race Jamaicans are the second largest racial group; the genetic roots of many people can be traced to origins that are not necessarily physically apparent. Christianity is the major religion in the island. Despite its location almost smack in the center of the Caribbean Sea, the island of Jamai...
Take a tour of Montego Bay in Jamaica in Montego Bay, Jamaica - part of the World's Greatest Attractions travel video series by GeoBeats. The resort town of Montego Bay, Jamaica is a mesmerizing location, celebrated for its beaches. This becomes evident as soon as you step on to the shores of Doctor's Cave Beach. This beach's resort reputation began in 1906 and is ideal for visitors who are looking for privacy and an escape from bustling city life. The sparking blue waters of the beach have a high mineral content, which is said to have healing powers. Montego Bay's surroundings have an aura of being untouched and unspoiled. Here, you'll find the blue skies, turquoise waters and sandy white beaches.
Take a tour of Top 5 Travel Attractions of Jamaica, Caribbean - part of the World's Greatest Attractions series by GeoBeats. Hi, this is your host, Naomi. I would like to guide you through the top 5 attractions of Jamaica. Number 5: Ocho Rios. It's a scenic resort town that offers many activities for visitors. You can explore the natural scenery, including lush gardens. Number 4: Martha Brae River Rafting. This slow, leisurely cruise on a river raft is a popular activity. You can take a day tour as well as a night tour. Number 3: Shopping. If you want to indulge in shopping during your visit, look for handicrafts. Intricately carved wooden pieces make for great gifts back home. Number 2: Montego Bay. It is Jamaica's second largest city. When you are here soak in the picturesque si...
Subscribe Now: http://www.youtube.com/subscription_center?add_user=Ehow Watch More: http://www.youtube.com/Ehow Jamaica conjures up images of beaches, reggae, rum and the perfect holiday destination. Get tips for people traveling in Jamaica with help from a travel expert in this free video clip. Expert: Kaamna Bhojwani-Dhawan Bio: Kaamna Bhojwani-Dhawan started Momaboard.com while living in Australia, and after the birth of her first child. Filmmaker: Steven Watkins Series Description: Traveling is great, but if you fail to properly prepare yourself or don't pack exactly what you're going to need, you can ruin a fun trip really quickly. Get travel tips and find out how to be as prepared as possible for wherever you choose to go with help from a travel expert in this free video series....
Here are our Top 7 Things to Do in Jamaica! We went in the spring of 2016. Arrived in Montego Bay and drove to Ocho Rios and then on to Negril. Here we show you our favorite things to explore while in Jamaica. Including: Dunn's River Falls http://www.dunnsriverfallsja.com Irie Blue Hole & Secret Falls http://www.blueholeochoriosjamaica.com Rick's Cafe http://www.rickscafejamaica.com Check out our blog for hostel reviews, tips, and directions http://www.tenacioustrekkers.com
My very first real travel experience to the island of Jamaica, alone, catching a bus to four major cities in 5 days. Subscribe and Check out my other travel videos! Blog | http://www.aperezvoyages.com Instagram | Aperezvoyages Facebook Page | https://www.facebook.com/aperezvoyages Snapchat : APerezVoyages This was my very first trip alone outside of the US. Very daring but very adventurous. Despite going in the middle of Hurricane Season, Tropical storm Issaac missed Jamaica and Atlanta and it only rained twice the whole time. :) Not only did i do everything i wanted but i also did everything i wanted within a set budget. I got the opportunity to see Montego Bay, Ocho Rios where i stayed, Negril overnight, and Kingston in just four days. Even though I spend half my time on the road, ...
HEY! (Watch in HD!) Hi everyone, I hope you all use at least one of these tips when packing for Jamaica at anytime! Thanks for your support. S A V E $ W I T H M E Sign up with AirBnb and get $20 when you use my code on your booking : www.airbnb.ca/c/twinnya Ebates (Cash back on online purchases + $10 when you sign up) : http://www.ebates.com/rf.do?referrerid=akPTzy%2FItnSIdqlFpmdVtg%3D%3D&eeid=28187 S T A Y C O N N E C T E D: My instagram - https://www.instagram.com/annesha.adams/ My website : http://www.twinstudios.ca/ ------------ M U S I C : https://www.youtube.com/user/lionriddims M Y E Q U I P T M E N T: Camera: Canon t5 Camera with kit lens → http://www.amazon.ca/dp/B00IJW024U Tripod→ walmart.ca Lighting: Ring Light → http://www.amazon.ca/dp/B00O1UCDK...
Watch more How to Visit Jamaica videos: http://www.howcast.com/videos/513628-Top-6-Places-to-Visit-Jamaica-Travel Planning a trip to Jamaica? Learn about the top six places to visit and what makes them special in this travel video about the popular Caribbean island. Recommendations include Doctor's Cave Beach, the Blue Mountains, Dunn's River Falls, and the Green Grotto Caves. Jamaica is the perfect place to relax, and there are a lot of ways to do it. If you only do one thing in Jamaica, spend some time on a beach–there are plenty to choose from. Doctor's Cave Beach is famous for its white sand and clear, calm water. When you're tired of the beach, cool off in the Blue Mountains, and find some delicious Jamaican Blue Mountain coffee to take home. From Blue Mountain Peak, you can...
Watch more How to Visit Jamaica videos: http://www.howcast.com/videos/513630-Best-Time-to-Visit-Jamaica-Travel Planning a trip to Jamaica? Learn about the best times of year to visit this beautiful Caribbean island in this travel video. Hint: Prices are low and skies are generally sunny from October to early December. It's hard to find a truly bad time to go to Jamaica. One of the island's biggest attractions is the beautiful beach weather that lasts year round. On the coast, which is where you'll probably want to spend most of your time, the temperature generally stays between 70 and 90 degrees all year long. Even during the rainy season from May to December, usually there will only be short periods of rain which will be followed immediately by sunshine. If you visit during ...
July 1st 2014 Gaja field's of Jamaica .. I explore a giant Blueberry Ganja Skunk field with Bubbleman and friends. We spend 10 days looking and exploring and feeling the Jamaican Vib, the air is warm and the vib is strong... Jamaica Blue Mountain® coffee is considered by many connoisseurs to be the world's finest, we also spend some time over looking the valley and talking to the caretaker of the land surrounding the coffee tress Music By Richie Spice Special Thanks to Jamaica Grow Your Own Grow In Peace
Si te gusto el video, dejame un laiktonzkli, comparte y suscribete si acaso quieres ver mas de mis estupideces, eso me vendria de poca madre :D Mi facebook:https://www.facebook.com/Jaimito-Ofichal-877243122311893 Twitter: https://twitter.com/JaimitOPJamaica Ayudenme a entender como funciona esta wea :v Gracias por ver, los hamo
Subscribe to VICE News here: http://bit.ly/Subscribe-to-VICE-News In Jamaica, attacks, murder, and rape are common occurrences against LGBTI people, with little to no retribution or justice brought against those responsible. After being forced from shacks, derelict buildings, and their own families, many homeless LGBTI Jamaicans have found refuge in the storm drainage systems of Kingston — known locally as the gully. For trans girls and gay men unable or unwilling to hide their sexuality, the sense of community and relative safety the gully provides acts as a welcome sanctuary, and for many, a hope of change to come. VICE News travelled to the New Kingston area to see what LGBTI life is like in Jamaica — where just being who you are can mean living a life underground. This unique comm...
This video is a photo slideshow using the pictures that I had taken in my first and second vacation to Montego Bay, Jamaica. Near the end of the slideshow I put in a few photo's of the resort in Runaway Bay, Jamaica that I had stayed at in my third trip there. I hope you enjoy! Music for Video: Bobby Bloom- Montego Bay UB40- Kingston Town UB40- Red Red Wine Bob Marley- Jammin' Future Fambo & Beenie Man ft Busta Rhymes- Rum & Redbull (Remix) Elephant Man ft Di Genius- In Jamaica *** some of the songs have been removed due to a claim..sorry if the music doesnt go throughout the video :(
by ,,FILMARI EVENIMENTE" tel 0761592300
Film made by Carillon Films for KLM Royal Dutch Airlines. Tourism in 1956. Shot in Aruba, Bonaire, Cuba, Curacao, Haiti, Jamaica, Trinidad and Tobago. With a young Mighty Sparrow doing the calypso theme song. Produced and directed by Ted de Wit and Ger Raucamp. "KLM Royal Dutch Airlines dedicate this film to the people and countries of one of the most beautiful playgrounds in the world."
Don't Just Watch and Go, For more exciting Videos, Click here to Subscribe to HipTv Official YouTube Channel: http://bit.ly/SubscribeToHipTv Enjoy! HipTv is a Nigerian urban contemporary music and lifestyle channel, borne out of the need to create rich compelling contents for the youth audience. The channel is known and respected for entertainment news, incisive and exclusive interviews, red and carpet moments amongst others. HipTv has over 26 exciting programmes that cuts across almost any topic under music and lifestyle umbrella. HipTv is largely regarded as the number one music content channel from Nigerian to Africa and the world. The channel was founded by its executive producer Ayo Animashaun and was launched in July 2007 as a music programme syndicated across several terrestria...
big up all di artist flava starr and di crew,bubbling crew,GQ TV CREW,people if u skip u gonna miss something u gotta watch di dancers dem madddd!!! big up hunk a gold,and Simone aka sim sim keep doing u thing,easy blacks, and LG, kevin(prolong HD), GQ TV so sickly!!!!!!!!!!
Mixtape Original Kultcha - Likkle Jota & Athletic Dub Intitulada "Original Kultcha", a mixtape exalta nossas raízes africanas e a cultura dos Sistemas de Som de música Reggae que saiu da Jamaica e ganhou o mundo com mensagens conscientes e dançantes. Faixas: 01 - Intro 02 - Fyah! (Peace Dub ) 03 - Interior (Girlfriend in Dub) 04 - Discutir e Questionar (Don't Know Dub) 05 - Intro II - Máximo Respeito 06 - Acende o Fogo (Love Dub) 07 - Intro III - Convite 08 - Festa (Movements in Dub) 09 - Intro IV - Salve pras Quebrada 10 - Criaca (One Way Dub) Gravado dia 10 de agosto de 2017 em Mad Doc Lab, Osasco SP. Todas as letras e interpretações por Likkle Jota, exceto faixa 1, voz Barry Brown Produzido por Caius Caesar e André Coelho. Captação*, mixagem e masterização em Mad Doc Lab por Caius...
DOWNLOAD FULL MIX HERE:https://sellfy.com/p/fvt0/ or Visit my store at https://sellfy.com/djinfluence1 to get get a larger selection on mixes to download. Donate to my channel here: http://bit.ly/2e4GT8e Positive reggae vybz something to chill on. (█▬█ █ ▀█▀ subscribe, █▬█ █ ▀█▀ like & comment)))) https://www.youtube.com/user/auguiste21 - check out my other channel https://www.facebook.com/DJINFLUENCE1 - like my fan page https://twitter.com/djinfluence1 - follow me on twitter https://www.mixcloud.com/auguiste1 - Follow me on MixCloud EMAIL :email@example.com BBM pin: 5584EE6D _________________________________________________ (((FOR PROMO USE ONLY))) DISCLAIMER!!! I Do Not Own Song/Songs In This Video, They Belong To It's Respective Owners. Please Support The Artist/Artist...
Fotografo/Operatore video/Regia/Montaggio Photographer /videomaking & edit IVAN MAZZOCCO Free Lance /Produzione di Foto e Video Indipendenti 2013 Independent/ Photo/Video Production 2013 language:italian,english & spanish Official photographer : Ivan Mazzocco Independent Photos&Videomaking Official photographer / Fotografo ufficiale Ivan Mazzocco Contact email email@example.com North East Ska Jazz Orchestra & Mr T Bone live in Aviano (pn) Italy 21/09/2013 Fusion Art Festival Aviano(pn) Italy
Meet the Martha Stewart of Marijuana: http://bit.ly/2gTh2PQ Check out other videos from Weediquette here: http://bit.ly/1iVLbL7 You might not know who Arjan Roskam is, but you've probably smoked his weed. Arjan's been breeding some of the most famous marijuana strains in the world—like White Widow, Super Silver Haze, and many others—for over 20 years. In 1992 he opened his first coffee shop in Amsterdam and has since crafted his marijuana-breeding skills into a market-savvy empire known as Green House Seed Company, which rakes in millions of dollars a year. He's won 38 Cannabis Cups and has dubbed himself the King of Cannabis. VICE joins Arjan and his crew of strain hunters in Colombia to look for three of the country's rarest types of weed, strains that have remained genetically pure...
Notizie, risultati e foto: http://ow.ly/YhBIb
Reggae mix ! Smoke marijuana ! 1*Intro Jingle Bobo David 2* Ziggy Recado 3*Cali P 4*Alpha Blondy 5*Junior Kelly 6*Chezideck 7*Zacharri 8*Alborosie Michael Rose 9*Eek A Mouse 10*Lorenzo 11*Mark Wonder Ziggy Recado 12*Perfect Giddimani 13*Sizzla 14*Midnite 15*Jah Mason 16*Ras Shiloh 17*Gentleman Tony Rebel
Razor Birthnight Bash, Jamaican Dance Hall At Night Traxx Bar, Bamboo, St. Ann, On January 21, 2013, Music By: DJ Brondon from Trendsetter, DJ Chang & DJ Garro Skill, from Weed Money,


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Ukulele Lessons & Classes in Gables Estates
Find the perfect teacher or instructor in Gables Estates for private ukulele lessons in your home or in their studio.
Popular Ukulele Teachers near Gables Estates
Check out some of our most popular teachers near Gables Estates including Miami, Miami Beach, Coral Gables, Key Biscayne and Hialeah.
About Aaron D.Close
View Full Profile
The Ukulele has seen a resurgence in recent years, and is a really fun and easier instrument to learn. Like the guitar, I teach beginners basic chords and rhythms to get them playing their favorite songs as soon as possible.
About Aaron
To tell you a little about myself, I was exposed to music at a very young age since my dad was a musician. I first picked up the drums at the age of 5, and took piano lessons for a year when I was 6. I later played the saxophone in 4th grade, and finally discovered the guitar when I was 9. (Ironic since my dad is a guitarist and the guitar was around the house forever!) He showed me my first chords and really got me started on the instrument, and I played in several local bands in high school playing a range of musical styles from rock, blues, funk, and reggae. I really didn't take music seriously until I was in college, and began studying under Jerry Coelho, a member of the very first graduating class of the Guitar Institute of Technology in Hollywood, CA, and
*** Lesson Details ***
I am a very easy going, friendly individual who believes that learning music is built upon a strong relationship between teacher and student. This relationship involves good communication, honesty, open mindedness, and most importantly the desire to LEARN and have FUN. I approach teaching music by knowing and understanding the student's musical goals, and teaching fundamentals, theory, and technique through the style(s) of music that the student wants to learn. For beginners, I tend to teach basic techniques and chords through simple songs to get the student playing music as quickly as possible.
*** Studio Equipment ***
Living Room: couches, table and TV, music stand, student can borrow instrument for first lesson, parents can sit in on lesson
*** Specialties ***
My main musical styles that I perform and teach are rock, blues, jazz, funk, R&B, and reggae. I studied jazz in college so I also have extensive knowledge of jazz theory.
· Music Performance · In studio
· Guitar · Online
· Ukulele · In home
Aaron D.
Aaron D.
About Dan G.Close
After 30 years of guitar playing, I recently bought a uke. I can't believe how much fun it is and pretty easy to get started on. Give me 30 mins and I'll teach you 2 songs on your first lesson!
About Dan
*** Lesson Details ***
I am laid back with a serious approach.A fellow actor recently mentioned to me how acting is stressful, I had never thought about it until then and he's right! The stress has never bothered me though because I always am very prepared. I will teach you the skills to be prepared and well rehearsed so that the performance comes easily.
I do not teach music theory but I can teach you to play guitar or ukulele.
*** Travel Equipment ***
I own 5 guitars, a ukulele, a mandolin and a keyboard. They just need a guitar.
*** Specialties ***
Classic Rock, Oldies, Pop Rock, Pop, R&B, Travis Picking and other types of finger picking.
· Theater Acting · In studio
· Ukulele · In studio
· Acting · In studio
Dan G.
Dan G.
About Jonathan S.Close
View Full Profile
From Hawaii to the UK, we can work on the music you want to learn. Ukulele is easy to start strumming in no time!
About Jonathan
I am a Florida native, active doctoral student, teacher and practitioner. My career includes performing and recording as a guitarist and teaching subjects such as music or math. Grade-school academic strengths in mathematics represent my enthusiasm for the subject. The math equivalent in music can be considered music theory, which is another passion of mine. I hope to take these well-rounded characteristics to teach and influence others with what I have learned in my education and career thus far.
Education & Teaching Experience:
I am currently pursuing my Doctorate of Musical Arts from Shenandoah University and hold a Masters of Music from the University of Akron and a Bachelor of Music from Stetson University (all degrees with a guitar performance emphasis). I also have a temporary teaching certificate for Music K-12 fro
Doctorate of Musical Arts: Guitar Performance; Shenandoah University, expected May 2017/2018
Master of Music: Guitar Performance; University of Akron, May 2014
Bachelor of Music: Guitar Performance; Stetson University, 2011
While giving lessons:
I ensure that every student receives fundamental foundation pertaining to the subject. While learning the basics, I advise that the student organizes their lessons and materials in a way that displays progress over time. With the proper knowledge, we can treat the heart of a subject with refinement in order to grasp it's purpose and reason---whether its music or math.
My students have grown with confidence through a sense of accomplishment. Success does not only affect a person's well-being but can also impact other dimensions of their lives.
*** Studio Equipment ***
Equipment available if needed:
Foot stools
Music stands
Complete home recording studio
Computer/tablet/smartphone w/ internet
Speakers and playback devices
Reference books
*** Travel Equipment ***
Each student is expected to bring with them (if applicable):
Notebook or log
Reference/score materials
Instrument(s) and case
Portable sound recorder (optional)
*** Specialties ***
Classical, Jazz and Rock Styles.
Performance, Music Theory, Arranging, Composition.
Elementary Math, Pre-Algebra, Algebra, Geometry, Statistics, Trigonometry, Pre-Calc.
· Piano · In home
· Guitar · In studio
· Trumpet · Online
Jonathan S.
Jonathan S.
About Nicole C.Close
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Learn great songs and feel the spirit of a tropical island while you learn. Choose your own songs or I can suggest songs. Let the fun begin!
About Nicole
As an adult, Nicole studied to become an elementary teacher and worked in the New York State Sch
Nicole now resides in Tampa, Florida with hopes to spread her business as well as the joy of music to children and adults. She currently is the singer for a local original rock band. In this band, Nicole writes songs, sings, plays guitar/piano (not all at the same time). Needless to say, she understands the importance that music has had in her life and wishes to ignite that passion in other music lovers.
*** Lesson Details ***
My teaching style is best labeled as kind but firm. I take my job very seriously and want wholeheartedly for my students to have music as a part of their life, not just a part of their day. I love to laugh and have fun but I will definitely expect my students to practice and complete any homework I assign and be prepared for the following lesson. Simply stated, music is fun and the love of my life, but if I still practice, you will as well. Otherwise, I always believe in teaching songs my students are interested in and will expand their musical skills. My experience as a public school teacher had enhanced my sense of finding individual needs of every student. Therefore, I always differentiate lessons to suit my students interest while teaching them the foundations every musician needs in order to be successful. My specialty is teaching a variety of instruments. I play drums, guitar, bass, piano, and sing as well. So, if one instrument is not for you, I can teach you something different without a problem. Long story short, friends, you are in good hands.
*** Studio Equipment ***
Full Service music room: Keyboard, Full drum kit, Electric Guitar with 30 watts Amp and Microphone/ vocal monitor.
*** Travel Equipment ***
I can bring a 76 key Yahama YPG-235 Keyboard for your household to use for lessons for a small monthly rental fee. I have an Epiphone Electric Guitar with 30w amplifier. Will also bring microphone and monitor for vocal lessons.
*** Specialties ***
I have taught mostly Rock, Blues, and Classical genres for Piano, Guitar, Drums. Vocally, I specialize in R&B, Broadway, Pop, Top 100 and alternative/Hard Rock. I will adapt to your needs.
· Singing · In studio
· Songwriting · In studio
· Guitar · In home
Nicole C.
Nicole C.
About Rob H.Close
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Ukulele lessons are taught one-on-one and from a beginner level to an intermediate level. Ages of students start at 6-years-old and up. I have many adult students as well. It's never too late to start a new instrument.
About Rob
Some of my most noteworthy performances have included Late Show with David Letterman (Justin Townes Earle and Allison Moorer), Tonight Show with Jay Leno (Allison Moorer), Levon Helm's Midnight Ramble (Allison Moorer), The Conan O'Brien Show (Julia Nunes) and Budokan in Tokyo, Japan (Jim Campilongo Trio).
My Bachelor of Music is from Capital University where I studied with three great teachers:
Robert Breithaupt - Classical percussion and jazz drum set
Jim Ed Cobbs - Drum set, tabla and frame drums
Eric Paton - Taiko, samba, Afro-Cuban drums
*** Lesson Details ***
I treat
I see my primary job as keeping the student inspired, intellectually fed and sprinting in the right direction. The student's job is to do the work. Daily practice is essential to move forward in any craft.
*** Studio Equipment ***
My Brooklyn studio is a dedicated music space with two drum sets, PA, amplifiers and recording capabilities.
*** Travel Equipment ***
I will provide books, a drum pad, sticks or mallets, an iPod with two sets of headphones, and a metronome. Additionally, I can bring small hand drums, special instruments and percussion that might be needed for specialty lessons. I expect students to have some sort of pad or drum to practice on at home; a full drum set is not necessary.
*** Specialties ***
Drum set (rock, jazz, R&B, folk, pop, electro, Afro-Cuban)
Snare drum
Two- and four-mallets (marimba, vibraphone, xylophone)
Accessory percussion
Frame drums
Traditional samba
Afro-Cuban hand drums
Japanese taiko
· Drum · In studio
· Ukulele · Online
David R.
· Drum · In studio
Rob H.
Rob H.
About Tara L.Close
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I learned from some great musicians out west that the ukulele can be really fun and have more range of notes too when tuned GDAE as a violin would be tuned. Ever since I learned that I have loved playing the ukulele and also have fun helping others to become well versed in playing many styles of music on there. One can play rhythm, melodies, improvise, write songs, play almost any style of music on a ukulele.
About Tara
· Mandolin · Online
· Guitar · In studio
· Ukulele · In studio
Tara L.
Tara L.
About Mark J.Close
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Enjoy the tropical sound of the ukulele but always thought it was too hard to learn? Not to 'fret' because I am here to teach you all the things you need to get started learning the ukulele.
About Mark
· Filmmaking · In studio
Mark J.
Mark J.
About Dillon S.Close
The ukulele is an extremely fun, easy and popular instrument to pick up, especially for kids! Many of the techniques and concepts learned can be transferred over to the guitar, bass, or even piano and violin. My teaching style is entirely student-oriented, and I adapt my material based on what you want to learn. I often use my music theory background as a supplement, and occasionally I will give handouts and homework. Students will need their own instrument and gear, and a notebook or binder!
About Dillon
I am a music and art teacher, and I have earned my Associate's degree in Music Education at MDC with a focus on jazz guitar. I have a fairly diverse experience in different genres of music (primarily worship/church music, but also rock, pop, punk/metal, jazz and others). I have also sung and played guitar, drums, and bass in numerous bands throughout the years (currently, drummer/percussionist for The Fortune Tellers in Miami, FL).
I have always had a deep love for art, and am currently working on my Bachelor of Science in K-12 Art Education. I have a particular interest in figure drawing/portraiture (charcoal, graphite, India ink), landscape and still life painting (acrylic and oil paint), and both digital and film photography.
I am hoping to improve my teaching skill
· Guitar · In home
· Ukulele · In home
· Guitar · In home
Dillon S.
Dillon S.
About Matt L.Close
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We will go through the Hal Leonard Ukulele method to get a good foundation on the instrument. Once the basics are learned, the real fun begins! We will learn any songs that you are interested in and discover what the instrument can do together.
About Matt
I can teach any style that you are interested in and can take students of all ages. I believe it is important to have a good musical foundation so we will go over music theory as well in lessons. I have extensive experie
· Ukulele · In home
· Ukulele · In home
· Acoustic Guitar · In home
Matt L.
Matt L.
About Phil C.Close
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Learn the basics of one of the most popular beginning instruments and you'll be playing any number of songs from whichever musical genre you enjoy. This is a great instrument for groups of 3 to 5 beginning students. For most people, this instrument is a quick learn.
The 15 minutes for $20.00 rate is for classes that actually span 90 minutes. This is the per person rate for sign up of a minimum of three people. Contact Phil for more details or call Take Lessons. Use the "Ask Phil" button or use the green button to sign up.
About Phil
My approach in private instruction involves tailoring the lessons to the specific needs of each student, while making sure that he/she has the knowledge and technique to succeed in their creative endeavors. Whether it's a hobby or a potential career, I leave nothing out. You will learn the entire instrument. In cases where a student works in more than one subject, one session can typically be applied
I also offer group lessons for 3 or more students. For friends at similar skill levels, this can offer a fun and more affordable way to learn a subject. It also serves as an additional motivator as the students in the group feed off of each other for ideas and inspiration.
Please feel free to contact me with the "Ask Phil a Question" button on my profile here. This can include questions about my method, or regarding days and times for lessons. What you see in my availability here is based on my schedule away from TakeLessons. I have students elsewhere and perform shows regularly. I may have additional times available and tend to have some flexibility. I teach worldwide online. Just ask.
As soon as you're ready to book lessons, you can use the Green Button after selecting your area of study, day and time. I will receive a notification that you've signed up. I will then confirm with you and send a questionnaire regarding your lesson needs within 48 hours.
Thanks for your interest.
I look forward to working with you!
· Acoustic Guitar · In home
· Vocal Training · In studio
· Acoustic Guitar · In studio
Phil C.
Phil C.
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subset: commoncrawl


text:
Henderson has struck a deal with financial services provider TIAA-CREF to create a real estate business running £41.5bn in property.
The joint venture, called TIAA Henderson Global Real Estate, will be formed after the two organisations combine their European and Asian real estate operations. Henderson, which owns 40 per cent of the joint venture, will receive cash proceeds of £114.2m.
In a related sale, Henderson will also sell its North American real estate business to TIAA-CREF.
The deal will allow the asset management house to focus on its global equities, European equities, absolute return, multi-asset and global fixed income activities.
Henderson property managing director James Darkins will head the venture, which will be staffed with more than 200 of Henderson's property team along with employees from TIAA-CREF. TIAA-CREF global real estate head Tom Garbutt will be chairman.
Darkins says: "The combination of TIAA-CREF's and Henderson's European and Asian real estate interests creates a new powerhouse in global real estate.
"Between us, we have the scale and capital resources to serve the real estate investing needs of our existing clients, as well as create exciting new opportunities to co-invest alongside them around the globe."
Henderson's property business is focused on institutional investors, with Ainslie McLennan and Marcus Langlands Pearse's £869.9m Henderson UK Property fund being the only portfolio aimed at retail investors.
McLennan and Langlands Pearse will continue to run the fund, while its investment process and style will not change because of the joint venture. Henderson adds that the fund remains "a key part" of its retail offering.


text:
|Bernards 1341 Sorrento Headboard Only - Queen Shipping Included
|Queen size artistic matte black metal headboard features flowing scroll design work creating a distinctive look. Purchase 2 headboards to make a complete bed. Bed frame sold separately. Dimensions: W 60.75 H 57.50 Approximate Weight: 36 pounds
CATEGORY-> Home/Family -> Furniture
BRAND-> Bernards -> 1341
SKU/UPC-> Bernards-1341 -> 708939134116
STATUS-> instock
Price: 158.00


text:
Yes I Do
That is right, I use EP Mobile. A lot of times when I am at work, and I am on my break, or on my lunch, I will check my EP stuff through my phone, or when I can't sleep at night, but I don't wanna get on my laptop, I will do Ep through my phone, its fun and easy
deleted 26-30 2 Responses 0 Feb 24, 2010
how do you get mobile?
For the first few months of my EP life I could only respond to stories because of being stuck on the mobile version, but I found it to be beneficial to growing as a person. Listening to other people's opinions without being able to share mine much was a new thing in my life, thank you for sharing your story :)


text:
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This meta-analysis was updated with results from a new trial and final data to reassess the efficacy and safety of bevacizumab combined with chemotherapy in ovarian cancer (OC).
Randomized controlled trials (RCTs) were searched in PubMed, EMBASE, Cochrane clinical trials, Web of Science and clinicaltrial.gov databases. Outcomes included the progression-free survival (PFS), overall survival (OS), objective response rate (ORR) and common adverse events. The hazard ratio (HR), risk ratio (RR) and odds ratio (OR) were pooled when the meta-analysis was performed.
Five RCTs with 4994 patients were included. In overall newly diagnosed OC, bevacizumab combined with chemotherapy did not significantly improve PFS (HR 0.85, 95%CI 0.70-1.02) or OS (HR 0.94, 95%CI 0.84-1.05). In the high-risk progression subgroup, the addition of bevacizumab significantly improved PFS (HR 0.76, 95%CI 0.68-0.84) and OS (HR 0.85, 95%CI 0.74-0.96). In recurrent OC, the addition of bevacizumab to chemotherapy significantly extended PFS (HR 0.53, 95%CI 0.45-0.63) and OS (HR 0.87, 95%CI 0.77-0.99). The ORR was improved (OR 2.37, 95%CI 1.99-2.82) in the overall population. Bevacizumab increased the incidence of hypertension (RR 21.27, 95%CI 9.42-48.02), proteinuria (RR 4.77, 95%CI 2.15-10.61), bleeding (RR 3.16, 95%CI 1.59-6.30), GI perforations (RR 2.76, 95%CI 1.51-5.03), arterial thrombosis events (RR 2.39, 95%CI 1.39-4.10) and venous thrombosis events (RR 1.43, 95%CI 1.04-1.96).
Bevacizumab combined with chemotherapy significantly improved PFS and OS in both patients with high-risk of progression and patients with recurrent OC, with an increased incidence of common adverse events. However, no statistically significant survival benefit was identified in the front-line settings.
Ovarian cancer (OC) carries one of the worst prognoses among gynecological tumors and is the fifth cause of cancer death among women [1]. The standard treatments for ovarian cancer include appropriate surgery or cytoreduction followed by adjuvant chemotherapy in most patients. Evidence indicates that overall survival (OS) is increased in patients who receive systemic chemotherapy. However, 70% patients with advanced ovarian cancer will relapse and even die after the adoption of surgery and chemotherapy [2]. More novel therapeutic options are explored in the recent study.
Bevacizumab is an anti-VEGF antibody that has demonstrated activity in ovarian cancer [3]. Several randomized controlled trials (RCTs) have been launched to evaluate the efficacy and safety of bevacizumab combined with chemotherapy in ovarian cancer. However, the survival benefit of bevacizumab was different in these trials. In 2015, final data from the ICON7 trial indicated that progression-free survival (PFS) was not statistically improved [4], and this result differed from other trials [5–8]. In addition, an exploratory analysis from the ICON7 trial presented the survival benefit in high-risk patients as significantly improved [9], but this finding was inconsistent with the GOG-218 trial [8] that recruited a similar population. Notably, only the GOG-213 trial revealed that median OS was significantly extended in patients who received bevacizumab combined with chemotherapy treatment [5].
Furthermore, previously reported preliminary data could not accurately reflect the survival benefit. The most recently published meta-analysis indicated that OS was improved by bevacizumab combined with chemotherapy for newly diagnosed OC [10], whereas the final data from several trials did not support this opinion. In this present study, the final data and a new RCT (GOG-213) were included to reassess the efficacy and safety of bevacizumab combined with chemotherapy in ovarian cancer.
We initially identified 147 articles from all searched databases, and 24 articles were retained after a full-text screening for inclusion in our review after excluding duplicates, reviews, and phase I and phase II trials. Finally, 5 randomized controlled trials with 4994 patients met our inclusion criteria (Figure (Figure1).1). The main characteristics of 5 RCTs were summarized in Table Table1,1, and the data of outcomes were summarized in Table Table2.2. The overall risk of bias was judged to be low (Figure (Figure2).2). The blinding of participants minimally influenced the survival time. The risk of bias was unclear in the study that was published in an abstract form.
In the newly diagnosed setting, bevacizumab combined with chemotherapy had no statistically significant improvement in PFS (hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.70-1.02, p = 0.03, I2 = 79%,) (Figure (Figure3).3). In contrast, PFS was significantly improved in the recurrent setting (HR 0.53, 95% CI 0.45-0.63, p = 0.12, I2 = 54%). Considering the large heterogeneity between newly diagnosed settings (I2 = 79 %, p = 0.03), the random-effects model was utilized for further subgroup analysis. The benefit on PFS in patients with a high risk of progression was significant (HR 0.76, 95% CI 0.68-0.84, I2 = 0%) (Figure (Figure33).
Bevacizumab had a significantly better OS in both the recurrent setting (HR 0.87, 95% CI 0.77-0.99, I2 = 0%) and the patients with a high-risk of progression (HR 0.85, 95% CI 0.74-0.96, I2 = 0%) (Figure (Figure4).4). No statistically significant improvement was identified in newly diagnosed setting (HR 0.94, 95% CI 0.84-1.05, I2 = 0%).
Three trials of objective response rate (ORR) have been reported, and the pooled odds ratio (OR) for ORR was 2.37 (95% CI 1.99-2.82, I2 = 0%) (Figure (Figure5).5). This finding demonstrates that bevacizumab combined with chemotherapy improved the ORR more effectively compared with chemotherapy alone.
Figure Figure55 presents presents66 common adverse events that are potentially associated with bevacizumab. Among this updated analysis, the risks of hypertension, proteinuria, bleeding, wound healing disruption, GI perforations, arterial thrombosis events and venous thrombosis events were significantly increased as follows: hypertension (risk ratio (RR) 21.27, 95% CI 9.42-48.02, I2 = 0%), proteinuria (RR 4.77, 95% CI 2.15-10.61, I2 = 0%), wound healing disruption (RR 3.55, 95% CI 1.09-11.59, I2 = 0%), bleeding (RR 3.16, 95% CI 1.59-6.30, I2 = 0%), GI perforations (RR 2.76, 95% CI 1.51-5.03, I2 = 0%), arterial thrombosis events (RR 2.39, 95% CI 1.39-4.10, I2 = 14%), and venous thrombosis events (RR 1.43, 95% CI 1.04-1.96, I2 = 39%) (Figure (Figure66).
Publication bias of the included trials was evaluated by funnel plot. The funnel plot for OS revealed almost symmetry, thus indicating no significant publication bias for OS (Figure (Figure7).7). PFS didn't do funnel plot, because the significant heterogeneity will lead to asymmetric funnel plot. Importantly, due to the number of trials is small (< 10), funnel plots have limited power to detect publication bias [11].
This updated meta-analysis was derived from a new RCT and final data to reassess the efficacy and safety of bevacizumab combined with chemotherapy in ovarian cancer. The conclusion is different from the previous meta-analysis. The updated results indicated that bevacizumab combined with chemotherapy significantly improved PFS and OS in patients with a high risk of progression and recurrent ovarian cancer. In addition, the ORR was significantly increased in the overall population.
Four trials (ICON7, GOG-218, OCEANS and AURELIA) were designed to observe the PFS as the primary endpoint. For recurrent ovarian cancer, bevacizumab combined with chemotherapy reduced the HR of progression by 47% compared with chemotherapy alone. For patients with a high risk of progression, the addition of bevacizumab reduced the HR of progression by 24% compared with chemotherapy alone. Notably, the pooled HR of PFS for the newly diagnosed setting was 0.85 (95%CI 0.70-1.02, I2 = 79%) with large heterogeneity. According to our analysis, the heterogeneity was mainly derived from the difference FIGO stages of the recruited patients. Thus, we performed further analysis in patients with a high risk of progression who were predefined in the ICON7 trial and matched all the recruited patients in the GOG-218 trial. The results indicated that the PFS was significantly improved in this subgroup (HR 0.76, 95% CI 0.68-0.84, I2 = 0%). Moreover, for the non-high-risk patients, bevacizumab did not improve OS (HR 1.14, 95% CI 0.93-1.40) or PFS (HR 1.03, 95% CI 0.88-1.21). This finding implies that the benefit from bevacizumab is associated with prognostic factors [9].
To our knowledge, the GOG-213 was the first phase III randomized trial designed to detect OS as the primary endpoint. Bevacizumab combined with chemotherapy reduced the HR of death by 13% in the recurrent setting and 15% in the patients with high-risk progression. The result from this updated data is consistent with a similar meta-analysis [12]. However, the OS as a secondary endpoint, the multiple lines of post-progression treatment and the crossover effect made it difficult to detect the OS benefit associated with bevacizumab in the others trials.
With the addition of bevacizumab, no significant decline in quality of life was noted even though the risk of several adverse events, such as hypertension, wound healing disruption, proteinuria, bleeding, GI perforations and thrombosis events, were relatively increased [13]. It is necessary to monitor and manage these adverse events during the bevacizumab therapy to minimize the risks [14]. If severe adverse events such as GI perforations can be controlled, bevacizumab can be used safely.
In newly diagnosed ovarian cancer, the overall population had no statistical survival benefit according to the two trials, ICON7 and GOG-218. Remarkably, in patients with a high risk of progression, the evidence implies that bevacizumab confers a survival benefit. The addition of bevacizumab to first-line treatment in ovarian cancer would be a good option for patients with poor prognoses, such as stage III or IV patients after debulking surgery. However, the survival benefit of bevacizumab in high-risk patients was concluded from subgroup analysis. The results from subgroup analyses should be noted because the consistency of patient characteristics and principle of randomization were not ensured. The evidence must be verified by another trial with a placebo control. Fortunately, there were several options for adjuvant therapy of newly diagnosed ovarian cancer. Firstly, chemotherapy based on weekly paclitaxel and carboplatin is an option. The JGOG 3016 trial [15] showed that both PFS and OS were significantly extended with the use of weekly paclitaxel and carboplatin compared with standard chemotherapy, whereas the GOG-262 trial [16] and the MITO-7 trial [17] showed that a dose-dense paclitaxel regimen did not prolong PFS significantly. The ICON8 trial (ISRCTN10356387), which addresses the same issue, is ongoing. Secondly, neoadjuvant chemotherapy accompanied with cytoreductive surgery or intraperitoneal chemotherapy could be considered in treatment [8]. Therefore, clinicians must select an appropriate front-line therapy for patients with advanced ovarian cancer.
Even if a pathological complete response is achieved, the recurrence rates are greater than 40%. Thus, almost all patients will eventually die from recurrence [18]. The most important goal in the treatment of recurrent ovarian cancer is prolonging the survival time using both an effective and well-tolerated strategy. The results of three trials (OCEANS, AURELIA and GOG-213) in this meta-analysis demonstrate that bevacizumab combined with chemotherapy is a great treatment option for recurrent ovarian cancer. Among the three trials, OCEANS and GOG-213 were aimed at platinum-sensitive ovarian cancer and AURELIA was aimed at platinum-resistant ovarian cancer relatively. The median PFS and OS of platinum-resistant patients were significantly reduced compared with platinum-sensitive patients [Table [Table2].2]. The result of a similar trial, TRINOVA-1, which was designed for platinum-resistant ovarian cancer, shows that trebananib also significantly increases the median PFS (7.2 months versus 5.4 months) relative to placebo [19].
Several problems must be addressed for bevacizumab-containing therapy in ovarian cancer. Firstly, the optimum dose of bevacizumab in the treatment of ovarian cancer is undefined [20]. The ICON7 trial used 7.5 mg/kg bevacizumab based on the dose in colorectal cancer, whereas the others trials used 15 mg/kg bevacizumab based on the dose for non-small-cell lung cancer. To date, no head-to-head trial has indicated the difference of survival benefit between two doses. Secondly, the efficacy of bevacizumab in recurrent patients who received bevacizumab in front-line therapy is unclear. In the TANIA trial for breast cancer and the ML18147 trial for colorectal cancer, the results indicate that bevacizumab provides clinical benefit for patients with recurrent disease who responded to first-line bevacizumab with chemotherapy [21, 22]. The MITO16 trial (NCT01802749), which addresses a similar issue in ovarian cancer, is ongoing. In addition, cost-effectiveness is essential and should be considered for the patients.
This updated meta-analysis included 5 RCTs with 4994 patients, whereas the previous publication contained 4 RCTs with 4246 patients. One additional trial, GOG-213, had final results published in abstract form from conference proceedings. Moreover, the final data from the OCEANS trial (OS) and the ICON7 trial (PFS, OS) were published recently. Previously reported preliminary data could not accurately reflect the survival benefit. The conclusion of the most recent meta-analysis showed that bevacizumab combined with chemotherapy improved PFS and OS in the front-line setting in ovarian cancer instead of improving the OS in the recurrent setting [10]. However, the result of this updated meta-analysis indicates that bevacizumab combined with chemotherapy improves PFS and OS in a recurrent setting, with no statistically significant improvement in PFS and OS for newly diagnosed OC. This result has considerable clinical significance indicating that the benefit of bevacizumab in ovarian cancer may be associated with prognosis factors, identifying patients who benefit most from bevacizumab and providing a high level of evidence for the rational use of bevacizumab in ovarian cancer.
The main limitation of this meta-analysis is the clinical heterogeneity across the studies, including the different tumor stages, the length of follow-up, the dose of bevacizumab, and the chemotherapy regimens. Secondly, we pooled HR for time-to-event data rather than assessing individual patient data. Thirdly, some negative trial results may not be published, thus excluding unpublished trials may introduce bias. Finally, this meta-analysis only included 5 RCTs, which was insufficient to analyze sensitivity.
The literature search focused on randomized controlled trials published from database inception to May 2016. Studies comparing bevacizumab plus chemotherapy with chemotherapy alone were eligible for inclusion. We searched the PubMed, EMBASE, Web of Science and Central (Cochrane clinical trials database) databases, and we also searched clinicaltrial.gov. We used the search terms "bevacizumab", "Avastin", "chemotherapy", and "ovarian cancer" in various combinations. In addition, only phase III randomized trials were restricted in the search strategy. The language of an article published was not restricted.
In order to explore the general efficacy of bevacizumab and to avoid biased conclusions, we used the same criteria as the previous meta-analysis [10]. Selection criteria followed the "PICOS" principle (P, population: women with ovarian cancer; I, intervention: chemotherapy plus bevacizumab; C, comparison: chemotherapy alone; O, outcome: efficacy and safety; and S, study: randomized controlled trial). Initially, articles that did not conform to the principles were excluded by reading the title and abstract. Subsequently, full-text evaluation was adopted when the first step could not determine inclusion or exclusion, and then the irrelevant article was excluded. Two investigators independently completed all of the processes. Discrepancies were resolved by discussion.
The risk of bias was assessed using the Cochrane Collaboration's tool. The risk of bias assessment was judged by three categories for each study: low risk (+), unclear risk (?) or high risk (-) of bias [23]. Data from each trial were classified into three domains: participant characteristics, study interventions, and outcomes. Participant characteristics contain participant sample size and stratification factors. Study interventions contain patient allocation and treatment regimens. The data of outcomes were extracted as follows: PFS, OS, ORR and incidence of adverse events. When two intervention groups were designed in the trial, only one intervention group that is most similar to the others trials was selected [24]. All processes were completed independently by two reviewers, and disagreements were resolved by discussion to reach a consensus according to Kappa index [25].
As a time-to-event outcome, PFS and OS were evaluated by using the HR. The HR and two-sided 95% CI were extracted directly from the trial reports. The Chi-squared test and Cochran Q-test were used to evaluate heterogeneity among trials, and I2 > 75% indicated considerable heterogeneity [26]. We pooled PFS in a random effects model based on the large heterogeneity among the different trials. For OS, ORR and adverse events, we used the fixed effect model. We pooled the RR for the adverse events and OR for ORR to assess the efficacy and safety. Subgroup analyses were adopted to determine whether there is survival benefit for patients in the subgroup classified by prognostic factors. A high risk of progression was defined in the ICON7 trial as FIGO stage III or IV disease after debulking surgery. The high-risk progression group consisted of 502 patients and matched all populations in the GOG-218 trial. The meta-analysis software RevMan 5.3 provided by the Cochrane library was used for the data analysis. Due to the small quantity of included trials (< 10), we did not examine potential publication bias with Begg and Egger tests.
This updated meta-analysis indicates that bevacizumab combined with chemotherapy significantly improved PFS and OS in both patients with high-risk of progression and patients with recurrent OC, with an increased incidence of common adverse events. However, no statistically significant survival benefit was identified in the front-line settings. ORR is improved in overall population by the addition of bevacizumab.
This work was supported by the National Key Clinical Specialist Construction Programs of China ([2013] NO. 544).
All authors claimed no competing interests.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
iCrossing, a digital marketing company, holds its own marketing platform, which can be tailored for clients. The company also offers planning services and development services. Its planning services include primary customer research, comp...
Adjust is leading in Top 10K Sites, Top 100K Sites, Top 1M Sites and The Entire Web.
In terms of market share, iCrossing is clearly lagging behind, losing to Adjust in all segments.
iCrossing has better usage coverage in more websites categories. Including Business & Industry, People & Society, Arts & Entertainment, Internet & Telecom and 106 other categories.
Adjust is leading in Shopping, Games, Clothing, Travel and 59 other categories.
Adjust is leading in most countries, including Germany, United States, Russia, France and 122 other countries.
iCrossing is leading in Israel and Jersey.