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Support Assistant (administrative/clerical) jobs near Toronto, ON
Date Added
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Support Assistant (Administrative/Clerical)
City of Toronto-Toronto, ON
Join the award-winning Toronto Public Service as a Support Assistant. Experience performing various clerical support duties, some of which must relate to the...
Administrative Assistant
Humanscale-Toronto, ON
The Sales Support Coordinator is responsible for supporting the sales staff by providing administrative, clerical and customer support....
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Talentcor-Mississauga, ON
Support various departments. Other Clerical duties assigned. Talentcor Mississauga is recruiting for a Administrative/Clerical Assistant for our client in...
Collections Coordinator Team Lead
Fasken Martineau-Toronto, ON
Assisting with administrative, clerical and other duties related in the Firm's management. In addition, this role supports the Manager, Billing and Collections...
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ProTemps / ProTegé-Mississauga, ON
Support budgeting and bookkeeping procedures. Providing support to all employees, and ensure everyone works efficiently, the tasks of the office administrator...

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Content count371
Last visited
Days Won3
Community Reputation259 Excellent
About Jgtcracer
Advanced Member
Contact Methods
First Name
Profile Information
Lexus Model
Lexus ISF
Year of Lexus
UK/Ireland Location
Jgtcracer started following The relief of an MOT pass, Kemble 'Grand Tour' - 19th Nov 2017, Back in a ISF and and 2 others
Kemble 'Grand Tour' - 19th Nov 2017
Jgtcracer replied to Flytvr's topic in Lexus IS-F ClubI love that era of high altitude supersonic jets!!
It's ok, we understand that the ISF just doesn't do it for you any more.... So is the RCF a mid life crisis car?? I could do with a mid life crisis
It will happen, just need a leave pass from the wife, she certainly won't be coming! My hobby is the only thing that keeps me sane to be honest, it sounds strange but people really do build up an emotional bond with cars and I do have a relationship with it! Maybe that's why the wife hates my cars, she gets jealous!
Lol, I like that saying! Must remember it.
Ring Taxis
Jgtcracer replied to mike m's topic in Lexus IS-F ClubThat Megane was impressive!!
Makes sense from my perspective. Not enough of us as it is, especially in light of recent movement away from the ISF. The thought of ratty one day getting a GSF/RCF would mean I would also have to just for the forum banter
Well if any of us owners of red cars car help with the Mesa red let then let us know. If there's not many then we will be able to manage to track them down! Marcus
Finally took some piccys
Jgtcracer replied to SCB's topic in Lexus IS-F ClubYea, when you lock the car the mirrors will auto fold
It sounds really cheesy but things like these really are good PR for the ISF. It's a really good thread. Only worry I have is that the only people that will read it have already been converted! Lol
Spotted isf
Jgtcracer replied to Lexusman007's topic in Lexus IS-F Clubs*x on wheels, nice and dirty too!
The relief of an MOT pass
Jgtcracer replied to Nick W858's topic in Lexus IS-F ClubTwo V8s........ For when killing polar bears with one just isn't enough!! I was accused of destroying the planet last week because of the ISF by a driver of an electric Outlander. I reminded him that my extortionate road tax entitles me to destroy as many baby seals as I want. When he pays top dollar for road tax then he has the right to moan, until then shut it!
My RR-Racing Supercharger Build
Jgtcracer replied to Peter P18's topic in Lexus IS-F Club£10k isn't bad at all fitted. Was expecting near £12-13k. Will be interesting to see how the rear tyres and traction control cope at this time of year. Even in my car, depending on road surface, can still get the TC light to come on at 40mph+. Is there a way to maintain cruise control without using the active aspect?? Your going to have to dyno it, for our benefit of nothing else! Marcus
I'll see what I can do, it's how I like my women...... nice and dirty
Don't start here too!!!lol. (I think I started it on the other thread)
Warrington is-F
Jgtcracer replied to Big Rat's topic in Lexus IS-F ClubHow dare you!! I'm a modern man, in touch with my femenine side! I own a pink shirt you know


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|This page was generated automatically from The Delphi Super Page archive. If you have any remarks concerning this page please do not hesitate to mail me.
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|Home Page
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|© 1995-2006 Robert M. Czerwinski ( The Delphi Super Page a.k.a. DSP ).
All rights reserved.


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Not Logged In. Sign In Now | Register
Data last updated 10:33 PM, November 17, 2017
The Orca Place is located at the beautiful Coal Harbour neighbourhood. Quiet corner unit facing N.W. with corridor water & mountain view & the 2 bedroom with court Yard view; Good layout with balcony & flex area; Spaces Living room with area great for office & walk in kitchen to the dining solarium; updated bathrooms with granite counter top & flooring is installed with laminated wood. Rental & Pets is allowed. Price includes 1 parking & a good size storage. Minutes walks to the Seawall of Coal Harbour Park & City Centre; Close to Starbuck, Shopper Drug Mart, Urban Fare, Robson Street Shopping, Vancouver Convention Centre, Stanley Park, Light transit and transportation to all destinations.
Listing Information
- Prop. Type:
- Apartment/Condo
- Property Style:
- 5 Plus Level, End Unit
- Status:
- Active
- Condo/HOA Fee:
- $373.44
- City:
- Vancouver
- Bedrooms:
- 2
- Full Bathrooms:
- 2
- Neighborhood:
- Coal Harbour
- Area:
- Vancouver West
- Province:
- MLS® Number:
- Added On:
- Sep 26, 2017
- Listing Price:
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- Taxes:
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General Information
- Year Built:
- 1997
- Flr Area Fin - Total:
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- Floor Area Finish - Main Floor:
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- Tax Year:
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- Total Square Feet:
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Additional Information
- Basement Area:
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Other Information
- Features Included:
- ClthWsh/Dryr/Frdg/Stve/DW, Drapes/Window Coverings, Garage Door Opener, Microwave, Smoke Alarm, Sprinkler - Fire
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- End Date:
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This property is listed by Royal Pacific Realty Corp. and provided here courtesy of Sutton Group - 1st West Realty. For more information or to schedule a viewing please contact Sutton Group - 1st West Realty.
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Phone: 604-942-7211
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Phone: 604-942-7211
Inquire Via Email
The data relating to real estate on this web site comes in part from the MLS Reciprocity program of the Real Estate Board of Greater Vancouver and the Fraser Valley Real Estate Boards. Real estate listings held by participating real estate firms are marked with the MLS logo and detailed information about the listing includes the name of the listing agent. This representation is based in whole or part on data generated by the Real Estate Board of Greater Vancouver and the Fraser Valley Real Estate Board neither of which assume any responsibility for its accuracy. The materials contained on this page may not be reproduced without the express written consent of the Real Estate Board of Greater Vancouver and/or the Fraser Valley Real Estate Board.


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650 State Highway 16 S
Bandera, TX 78003
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Toasted Chocolate Hazelnut Granola, made with real cacao bits and balancing flavors such as hazelnuts and oats, coated with a generous layer of maple! Have you ever toasted oats and nuts? Ohh, let me tell you -you are in for a treat! The truth about GRANOLA As far as I am concerned buying store boughtRead More »
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Enjoy the best flavors of the season with this easy Strawberry Rhubarb Pie, made with few and fresh ingredients! Pies are a language of love. We serve pies whenever we host a dinner party. We gift pies as a warming thank you. Pies are so special that we have TWO National Pie Days!! (DecRead More »


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Fiber optic connectors are a substantial fragment of the global telecommunication industry. Optical fibers are joined using fiber optic connectors, which allow the light conduction between two consecutive optical fibers. An additional im…
Sales, means the sales volume of High Austenitic Alloys Tubes
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This report studies sales (consumption) of High Austenitic Alloys Tubes in United States market, focuses on the top players, with sales, price, revenue and market share for each player, covering
- Outokumpu
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- MAC Steel
- AK Steel Corporation
- Thyssen Krupp
- Pohang Iron & Steel (Posco)
- Ta Chen International
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- Mexinox
- Shree Khodal Industrial Engineering Company
- STAINLESS Products Ltd NZ
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Market Segment by States, covering
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- Seamless Tube
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Latest News
The garden at Stationers' Hall is always much enjoyed by members and by clients as a place of beauty in which to enjoy a pre-lunch or dinner drinks reception. It is also a haven for birds and several species can be seen enjoying the magnificent plane tree as a place to perch and forage for food. This year we are again fortunate that one pair has chosen the tree, or more specifically the ivy around the tree, in which to nest. It has happened before but cannot be counted upon each year. This year we have noticed them quite early on and will be watching to see how they get on.
At the Master & Wardens meeting on Monday, 15 May 2017 five people were made free of the Company. They were (from L-R in the photo): Mark Cole, Senior Partner - Bright Grahame Murray, Laura Dietz, Senior Lecturer- Anglia Ruskin University, Simon Fox, Chief Executive Officer - Trinity Mirror plc, Elizabeth Gill – Freelance Journalist and Philip Swinden, Managing Director - Haymarket Media Group Limited. Our congratulations go to them all and we look forward to seeing them at forthcoming events at the Hall.
At the Charter Dinner, as happens each year, the Paper Industry Gold Medal was presented to someone who is at the heart of the Paper Industry. This year is was awarded to Liveryman Martyn Eustace of Two Sides for his unrelenting work on behalf of paper. The Under Warden (pictured below) read out the following citation.
Kim Scott Walwyn was a Publishing Director at Oxford University Press and died in 2002 - much too early. In her memory this prize is awarded to exceptional women in publishing.
Yesterday saw the long-awaited opening of the Digital Media Centre at Stationers' Crown Woods Academy. This was a very proud moment for the Company; for those who have worked to bring the project to fruition and for those who have donated money, equipment and furniture.
On the same day as the Stationers' Digital Media Centre was opened at SCWA the University of Reading announced the discovery of a rare page of Caxton's print. Judging from the story on the BBC (click here to read in full) the tiny scrap has been about a bit and been unloved and unrecognised for its real worth for many, many years.
At the DMG event on Monday, 8 May, which was organised by Court Assistant Paul Wilson, and moderated by Liveryman Peter Day a panel of experts discussed cash and its future in the UK.
The nomination form for the Stationers' Warrants programme for 2018 is now available online here. Members are encouraged to both nominate their own products that they would want to recommend for a warrant and to spread the word amongst colleagues and contacts about the programme which is open to products from within the Communications and Content Industry. For details of the programme and previous winners please visit our Stationers' Warrants page, here. Nominations must be received by 16 June 2017.
On Wednesday, 3 May 2017 members of the Company celebrated in their usual fashion (with great food, wine, an entertaining speaker and convivial fellow diners) the awarding of the Company's charter of incorporation in 1557. This year the guest speaker was Lord Archer of Weston-super-Mare and as a memento of the evening the Master gave him a copy of The Stationers' Company - a History of the Later years 1800-2000 which was edited by the Honorary Archivist Emeritus, Robin Myers.
Members will be aware of the Master's bicycle ride taking place on 25 June 2017.


text:
Research Topics
Genomes and Genes
Gene Symbol: NLRC4
Description: NLR family CARD domain containing 4
Alias: AIFEC, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, FCAS4, IPAF, NLR family CARD domain-containing protein 4, CARD, LRR, and NACHT-containing protein, ICE-protease activating factor, NOD-like receptor C4, caspase recruitment domain family, member 12, caspase recruitment domain-containing protein 12, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
Species: human
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications201 found, 100 shown here
- Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activationChafen Lu
Millennium Pharmaceuticals, Inc, 35 Landsdowne Street, Cambridge, MA 02139, USA
Biochem Biophys Res Commun 331:1114-9. 2005b>CARD12 (Ipaf/Clan) is an important regulator of caspase-1 activation. It belongs to the family of the nucleotide-binding site and leucine-rich repeat (NBS-LRR) proteins...
- Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1Jean Marie Bruey
Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Cell 129:45-56. 2007..The findings reveal an interaction of host defense and apoptosis machinery...
- Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infectionAlessandra Pontillo
Laboratory of Medical Investigation in Dermatology and Immunodeficiency, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
J Acquir Immune Defic Syndr 59:121-5. 2012..Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls...
- Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemiaWei neng Fu
Department of Haematology Oncology, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
Oncogene 22:451-5. 2003..This study suggests that Apaf-1 DNA promoter methylation might contribute to the inactivation of Apaf-1 expression. However, Apaf-1 protein levels might also be controlled at post-transcription level...
- Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1J L Poyet
Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 276:28309-13. 2001..Here we describe the identification of a human Apaf-1-related protein, named Ipaf that contains an NH2-terminal CARD domain, a central nucleotide-binding domain, and a COOH-terminal regulatory ..
- NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorderLaetitia Agostini
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Immunity 20:319-25. 2004..Macrophages from Muckle-Wells patients spontaneously secrete active IL-1beta. Increased inflammasome activity is therefore likely to be the molecular basis of the symptoms associated with NALP3-dependent autoinflammatory disorders...
- Multiple roles of CLAN (caspase-associated recruitment domain, leucine-rich repeat, and NAIP CIIA HET-E, and TP1-containing protein) in the mammalian innate immune responseJason S Damiano
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
J Immunol 173:6338-45. 2004..Caspase-associated recruitment domain, leucine-rich repeat, and NACHT-containing protein (CLAN), also known as ICE protease-activating factor, belongs to a branch of the NACHT family that contains proteins ..
- Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosisSubhashini Sadasivam
Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
Oncogene 24:627-36. 2005..Here we show that Ipaf, a human CED-4 homologue and an activator of caspase-1, is induced by p53...
- Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell deathYatender Kumar
Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research CSIR, Uppal Road, Hyderabad 500007, India
Biochem J 427:91-104. 2010..on interacting proteins, and Ipaf [ICE (interleukin-1beta-converting enzyme)-protease activating factor] {NLRC4 [NLR (Nod-like receptor) family CARD (caspase activation and recruitment domain)-containing 4]} an inflammasome ..
- The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatusYue Zhao
Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Nature 477:596-600. 2011..The inflammasome assembled by the NOD-like receptor (NLR) protein NLRC4 responds to bacterial flagellin and a conserved type III secretion system (TTSS) rod component...
- Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellinEls F Halff
Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands
J Biol Chem 287:38460-72. 2012The NOD-like receptors NAIP5 and NLRC4 play an essential role in the innate immune response to the bacterial tail protein flagellin...
- Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosisSubhash Thalappilly
Centre for Cellular and Molecular Biology, Hyderabad, India
FEBS J 273:2766-78. 2006..We analyzed the role of ICE protease-activating factor (Ipaf), an activator of caspase 1 in p53-dependent apoptosis...
- A recombinant, chimeric enzyme with a novel mechanism of action leading to greater potency and selectivity than tissue-type plasminogen activatorJ H Robinson
Department of Biotechnology, SmithKline Beecham Pharmaceuticals, Surrey, England, UK
Circulation 86:548-52. 1992..active center acylation with a novel inverse acylating agent, 4'-amidinophenyl-4-chloroanthranilic acid (AP-CLAN). An acylated (CLAN-) hybrid was cleared from the bloodstream of guinea pigs at 0.35 +/- 0.02 ml/min...
- Arsenic-related skin lesions and glutathione S-transferase P1 A1578G (Ile105Val) polymorphism in two ethnic clans exposed to indoor combustion of high arsenic coal in one villageGuo Fang Lin
Laboratory of Toxicology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Pharmacogenet Genomics 16:863-71. 2006..This study aimed to investigate the cluster of arsenism cases and the possible relevant factors including GSTP1 polymorphism in two clans of different ethnic origin living in one village for generations...
- Purification and characterization of phytocystatins from kiwifruit cortex and seedsMaysoon Rassam
Gene Technologies, The Horticultural and Food Research Institute of New Zealand, PB 92169, Auckland, New Zealand
Phytochemistry 65:19-30. 2004..chinensis. The predominant cortex cystatin, KCPI1, inhibited clan CA, family C1 (papain family) cysteine proteinases (papain, chymopapain, bromelain, ficin, human cathepsins B, H ..
- Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and diseaseD P Dickinson
Medical College of Georgia, School of Dentistry, Department of Oral Biology, and Maxillofacial Pathology, Augusta 30912, USA
Crit Rev Oral Biol Med 13:238-75. 2002..In mammals, two of the major clans represented in the genome are: the CA clan, whose members share a structure and evolutionary history with papain; and the CD clan, which includes the ..
- Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic modelSamuel G Melendez-Lopez
Department of Pathology, University of California, San Diego, San Diego, California 92103 8416, USA
Eukaryot Cell 6:1130-6. 2007..Arginine was strongly preferred at P2, an unusual specificity among clan CA proteinases. A new vinyl sulfone inhibitor, WRR483, was synthesized based on this specificity to target EhCP1...
- Kininogens: More than cysteine protease inhibitors and kinin precursorsGilles Lalmanach
INSERM U618, Protéases et Vectorisation Pulmonaires, IFR 135 Imagerie Fonctionnelle, Universite Francois Rabelais, Tours, France
Biochimie 92:1568-79. 2010..Kininogens are multifunctional glycosylated molecules related to cystatins (clan IH, family I25)...
- Social evolution in the Hallstatt--La Tène periodVaclav Smrcka
Charles University in Prague, First Faculty of Medicine, Institute for History of Medicine and Foreign Languages, Prague, Czech Republic
Acta Univ Carol Med Monogr 156:27-56. 2009..Not only are the ruler and his "court" put in the graves, but also all the members of the clan. We suppose that the new social group of priests, who gained a high social prestige both in wartime and in ..
- Genome-wide structural and evolutionary analysis of the P450 monooxygenase genes (P450ome) in the white rot fungus Phanerochaete chrysosporium: evidence for gene duplications and extensive gene clusteringHarshavardhan Doddapaneni
Environmental Genetics and Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
BMC Genomics 6:92. 2005..In order to understand the functional diversity and the evolutionary mechanisms and significance of these hemeproteins, here we report a genome-wide structural and evolutionary analysis of the P450ome of this fungus...
- Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infectionAnwari Akhter
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, OH, USA
PLoS Pathog 5:e1000361. 2009..Most inbred mouse strains are restrictive to L. pneumophila infection except for the A/J, Nlrc4(-/-) (Ipaf(-/-)), and caspase-1(-/-) derived macrophages. Particularly, caspase-1 activation is detected during L...
- Identification of Asp-130 as the catalytic nucleophile in the main alpha-galactosidase from Phanerochaete chrysosporium, a family 27 glycosyl hydrolaseD O Hart
Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada
Biochemistry 39:9826-36. 2000..J. 316, 695-696]. This family, together with the family 36 alpha-galactosidases, forms glycosyl hydrolase clan GH-D, a superfamily of alpha-galactosidases, alpha-N-acetylgalactosaminidases, and isomaltodextranases which are ..
- Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4Anne Fortier
Department of Biochemistry, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler, Room 907, Montreal, Quebec, Canada H3G 1Y6
Infect Immun 77:4794-805. 2009..pneumophila. Moreover, macrophages doubly heterozygous (Naip5AJ/WT Irf8R294C/WT or Nlrc4-/+ Irf8R294C/WT) for combined loss-of-function mutations in Irf8 and in either Naip5 or Nlrc4 are highly ..
- Mutagenic definition of a papain-like catalytic triad, sufficiency of the N-terminal domain for single-site core catalytic enzyme acylation, and C-terminal domain for augmentative metal activation of a eukaryotic phytochelatin synthaseNataliya D Romanyuk
Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Plant Physiol 141:858-69. 2006..that the N-terminal half of AtPCS1 and its equivalents from other sources have the hallmarks of a papain-like, Clan CA Cys protease...
- Regulation of cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells by convergence of distinct beta1 and beta3 integrin pathwaysMark S Filla
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
Invest Ophthalmol Vis Sci 50:5723-31. 2009To determine the beta1/beta3 integrin-mediated pathways that regulate cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells...
- IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinusDaniel Sojka
Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic and Faculty of Biological Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic
Int J Parasitol 37:713-24. 2007..from the hard tick Ixodes ricinus (termed IrAE), which we believe is the first such characterisation of a clan CD family C13 cysteine peptidase (protease) in arthropods...
- Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophilaChristopher L Case
Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
Infect Immun 77:1981-91. 2009..pathway involving the host nucleotide-binding domain and leucine-rich repeat-containing protein Ipaf (NLRC4)...
- Crystal structure of aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli and conformational change of methionine 260 involved in substrate recognitionKiyoshi Ito
Graduate School of Biomedical Sciences, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
J Biol Chem 281:33664-76. 2006Aminopeptidase N from Escherichia coli is a broad specificity zinc exopeptidase belonging to aminopeptidase clan MA, family M1. The structures of the ligand-free form and the enzyme-bestatin complex were determined at 1.5- and 1...
- Matrix metalloproteinases: fold and function of their catalytic domainsCynthia Tallant
Proteolysis Lab, Molecular Biology Institute of Barcelona, CSIC, Barcelona Science Park, Helix Building, c Baldiri Reixac, 15 21, E 08028 Barcelona, Spain
Biochim Biophys Acta 1803:20-8. 2010..The catalytic domains of 13 MMPs have been structurally analyzed so far and they belong to the "metzincin" clan of metalloendopeptidases...
- Potential applications of smart clothing solutions in health care and personal protectionHarriet Meinander
Tampere University of Technology, SmartWearLab, Sinitaival 6, FIN 33720 Tampere, Finland
Stud Health Technol Inform 108:278-85. 2004..Clothing Area Network--Clan" is a research project aiming to develop a technical concept and technology needed in enabling both wired and ..
- cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix componentsA Colige
Laboratory of Connective Tissues Biology, University of Liege, Belgium
Proc Natl Acad Sci U S A 94:2374-9. 1997..The protein contained zinc-binding sequences of the clan MB of metallopeptidases that includes procollagen C-proteinase/BMP-1...
- Structural and functional characterization of binding sites in metallocarboxypeptidases based on Optimal Docking Area analysisDaniel Fernandez
Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
Proteins 68:131-44. 2007The metallocarboxypeptidases (MCPs) belonging to the clan MC were studied by the Optimal Docking Area (ODA) method to evaluate protein-protein binding sites and to provide a basis for the identification of binding partners for this class ..
- The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activationMohamed Lamkanfi
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
J Immunol 178:8022-7. 2007Similar to Ipaf and caspase-1, the Nod-like receptor protein Naip5 restricts intracellular proliferation of Legionella pneumophila, the causative agent of a severe form of pneumonia known as Legionnaires' disease...
- A role for Nod-like receptors in autophagy induced by Shigella infectionToshihiko Suzuki
Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
Autophagy 4:73-5. 2008..we presented evidence that caspase-1 activation and IL-1beta processing induced by Shigella are mediated through Ipaf, a cytosolic pattern-recognition receptor of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR)..
- [The active site of human glucocerebrosidase: structural predictions and experimental validations]Sylvie Fabrega
INSERM U458, Hopital Robert Debre, 48, bd Serurier, 75019 Paris
J Soc Biol 196:151-60. 2002..Glucocerebrosidase belongs to the clan GH-A of glycoside hydrolases, a large group of enzymes which function with retention of the anomeric configuration ..
- A study on the social structure and dispersal patterns of hamadryas baboons living in a commensal group at Taif, Saudi ArabiaAkio Mori
Primate Research Institute, Kyoto University, Kanrin, Inuyama, Aichi, 484 8506, Japan
Primates 48:179-89. 2007..one male unit (OMU), the band, and the troop--have been observed at all sites studied, but a fourth--the clan--has been observed at only one site, Erer-Gota, Ethiopia, during a longitudinal check of the dispersion of ..
- On the origins of arrestin and rhodopsinCarlos E Alvarez
Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
BMC Evol Biol 8:222. 2008..We conducted phylogenetic studies to reconstruct the history of arrestins. Those findings, in turn, led us to investigate the origin of the photosensory GPCR rhodopsin...
- Post-translational modifications of the basic peroxidase isoenzyme from Zinnia elegansCarlos Gabaldón
Department of Plant Biology, University of Murcia, 30100, Murcia, Spain
Plant Mol Biol 65:43-61. 2007..suggested that the processing of the N-terminal pro-peptide of ZePrxs is performed by a peptidase from the SB clan (S8 family, subfamily A) of serine-type proteases...
- Ov-APR-1, an aspartic protease from the carcinogenic liver fluke, Opisthorchis viverrini: functional expression, immunolocalization and subsite specificitySutas Suttiprapa
Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Int J Biochem Cell Biol 41:1148-56. 2009..viverrini. Phylogenetic analysis indicated that Ov-APR-1 is cathepsin D-like, conforming with Clan AA, Family A1 of the MEROPS classification...
- Intervention and prevention of hereditary hemolytic disorders in India: a case study of two ethnic communities of Sundargarh district in OrissaR S Balgir
Division of Human Genetics, Regional Medical Research Center, Indian Council of Medical Research, Opposite Kalinga Hospital, Chandrasekharpur, Bhubaneswar 751 023, Orissa
J Assoc Physicians India 56:851-8. 2008..For sustainability, imparting of relevant training to local paramedical staff, and to undertake periodic follow up for evaluation, intervention and clinical management through local PHCs/hospitals...
- Crystal structure of a dodecameric tetrahedral-shaped aminopeptidaseSantina Russo
Departement fur Chemie und Biochemie, University of Berne, Freiestrasse 3, CH 3012 Bern, Switzerland
J Biol Chem 279:51275-81. 2004..The monomer has a typical clan MH fold, as found for example in Aeromonas proteolytica aminopeptidase, containing a dinuclear zinc active center...
- Human tissue kallikreins: physiologic roles and applications in cancerCarla A Borgono
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5 Canada
Mol Cancer Res 2:257-80. 2004Tissue kallikreins are members of the S1 family (clan SA) of trypsin-like serine proteases and are present in at least six mammalian orders...
- Cysteine proteases of malaria parasitesPhilip J Rosenthal
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, Box 0811, San Francisco, CA 94143, USA
Int J Parasitol 34:1489-99. 2004..The best characterised Plasmodium cysteine proteases are the falcipains, a family of papain-family (clan CA) enzymes...
- Comparative molecular analysis of two asparaginyl endopeptidases and encoding genes from Fasciola giganticaPoom Adisakwattana
Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailand
Mol Biochem Parasitol 156:102-16. 2007In this study we describe the first cysteine proteinases of the MEROPS Clan CD family C13 in Fasciola gigantica...
- Leishmania subtilisin is a maturase for the trypanothione reductase system and contributes to disease pathologyRyan K Swenerton
Department of Pathology, Sandler Center for Drug Discovery, University of California, San Francisco, California 94158, USA
J Biol Chem 285:31120-9. 2010..The subtilisin protease (SUB; Clan SB, family S8) of Leishmania donovani was cloned and found to possess a unique catalytic triad...
- Characteristics of traditional birth attendants and their beliefs and practices in the Offot Clan, NigeriaS M Itina
St Luke s Hospital, Anua, Akwa Ibom State, Nigeria
Bull World Health Organ 75:563-7. 1997This article presents the findings of a survey of a group of 52 traditional birth attendants (TBAs) in a clan in south-eastern Nigeria...
- Update of the NAD(P)H:quinone oxidoreductase (NQO) gene familyVasilis Vasiliou
Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Hum Genomics 2:329-35. 2006The NAD(P)H:quinone acceptor oxidoreductase (NQO) gene family belongs to the flavoprotein clan and, in the human genome, consists of two genes (NQO1 and NQO2)...
- Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophagesLuigi Franchi
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Nat Immunol 7:576-82. 2006..b>Ipaf, a cytosolic pattern-recognition receptor in the family of nucleotide-binding oligomerization domain-leucine-rich ..
- The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolaseSandra Tribolo
Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
J Mol Biol 370:964-75. 2007..As for all the clan of GH-A enzymes, the two catalytic glutamate residues are located on strand 4 (the acid/base Glu165) and on strand ..
- Autosomal recessive hyponatremia due to isolated salt wasting in sweat associated with a mutation in the active site of Carbonic Anhydrase 12Emad Muhammad
Department of Virology and Developmental Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, 84105, Israel
Hum Genet 129:397-405. 2011..Three affected individuals from a small Bedouin clan presented with failure to thrive, hyponatremic dehydration and hyperkalemia with isolated sweat salt wasting...
- X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher diseaseHay Dvir
1 Departments of Structural Biology and Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
EMBO Rep 4:704-9. 2003..catalytic domain consists of a (beta/alpha)(8) TIM barrel, as expected for a member of the glucosidase hydrolase A clan. The distance between the catalytic residues E235 and E340 is consistent with a catalytic mechanism of retention...
- Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidaseSherwin Wilk
Department of Pharmacology, Box 1215, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Arch Biochem Biophys 407:176-83. 2002..DAP is a member of the M18 family of the MH clan of cocatalytic metallopeptidases. The human and mouse enzymes have been cloned...
- Interplay between acid phosphatase and cysteine proteases in mediating vitellin degradation during early embryogenesis of Periplaneta americanaDanielle M P Oliveira
Laboratorio de Entomologia Medica, Programa de Parasitologia e Biologia Celular, Instituto de Biofisica Carlos Chagas Filho, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro, RJ, Brazil
J Insect Physiol 54:883-91. 2008..In parallel, two classes of proteases were detected and located within yolk granules: a clan CA-cysteine protease, which was inhibited by E-64, insensitive to CA 074 and activated by acidic pH at day 3; and a ..
- On the relevance of the Met-turn methionine in metzincinsCynthia Tallant
Proteolysis Laboratory, Department of Structural Biology, Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Cientificas, Barcelona Science Park, Helix Building, c Baldiri Reixac, 15 21, E 08028 Barcelona, Spain
J Biol Chem 285:13951-7. 2010The metzincins are a clan of metallopeptidases consisting of families that share a series of structural elements...
- The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptorsThóra K Bjarnadóttir
Department of Neuroscience, Uppsala University, BMC, Box 593, 751 24, Uppsala, Sweden
Gene 362:70-84. 2005Glutamate receptors (also known as clan C) are one of the main groups of GPCRs with many subgroup linked through complex evolutionary relationships...
- One-male units and clans in a colony of hamadryas baboons (Papio hamadryas hamadryas): effect of male number and clan cohesion on feeding successFernando Colmenares
Departamento de Psicobiologia, Facultad de Psicologia, Universidad Complutense de Madrid, Campus de Somosaguas, Madrid, Spain
Am J Primatol 68:21-37. 2006..This paper examines the effect of male number and rivalry between males within a clan on their ability to compete for access to a clumped food resource...
- Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell deathSamuel H McCall
Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina, USA
J Bone Miner Res 23:30-40. 2008..We provide evidence for the functional expression in osteoblasts of NLRP3, a member of the NLR family of cytosolic receptors that has been implicated in the initiation of programmed cell death...
- Structural basis of murein peptide specificity of a gamma-D-glutamyl-l-diamino acid endopeptidaseQingping Xu
Joint Center for Structural Genomics, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA
Structure 17:303-13. 2009..The NlpC/P60 domain is a primitive, papain-like peptidase in the CA clan of cysteine peptidases with a Cys126/His176/His188 catalytic triad and a conserved catalytic core...
- ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infectionJoao H F Pedra
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 179:4783-91. 2007..phagocytophilum. The NLR family member IPAF/NLRC4, but not NALP3/NLRP3, was partially required for IFN-gamma production in response to A. phagocytophilum...
- Incest in Palau: "Delemumuu undressed"Stevenson Kuartei
Ministry of Health, Republic of Palau
Pac Health Dialog 12:84-91. 2005..It is the level of kebliil where incest is defined and could differ from clan to clan...
- Cysteine peptidase expression in Trichomonas vaginalis isolates displaying high- and low-virulence phenotypesJose Batista De Jesus
Departamento de Ciencias Naturais, Universidade Federal de Sao Joao del Rei, Sao Joao Del Rei, MG, Brazil
J Proteome Res 8:1555-64. 2009..Seven of the eight CPs identified belong to Clan CA, family C1, cathepsin L-like CP, and one belongs to Clan CD, family C13, asparaginyl endopeptidase-like CP...
- Transcriptional activation by the sexual pheromone and wounding: a new gene family from Volvox encoding modular proteins with (hydroxy)proline-rich and metalloproteinase homology domainsA Hallmann
Lehrstuhl Biochemie I, Universitat Regensburg, Universitätstr 31, D 93053 Regensburg, Germany
Plant J 26:583-93. 2001..Sequence comparisons suggest that the VMPs are members of the MB clan of zinc-dependent matrix metalloproteinases, although the putative zinc binding site of all VMPs is QEXXHXXGXXH ..
- Structural aspects of the metzincin clan of metalloendopeptidasesF Xavier Gomis-Ruth
Institut de Biologia Molecular de Barcelona, CID CSICC Jordi Girona, 18 26 08034 Barcelona, Spain
Mol Biotechnol 24:157-202. 2003..All these structural features identify the metzincin clan of metalloendopeptidases...
- Identification of acceptor substrate binding subsites +2 and +3 in the amylomaltase from Thermus thermophilus HB8Thijs Kaper
Centre for Carbohydrate Bioprocessing TNO, University of Groningen, 9751 NN Haren, The Netherlands
Biochemistry 46:5261-9. 2007Glycoside hydrolase family 77 (GH77) belongs to the alpha-amylase superfamily (Clan H) together with GH13 and GH70...
- Minimal motif peptide structure of metzincin clan zinc peptidases in micellesAkira Onoda
Faculty of Science, Department of Chemistry, Tokyo University of Science, Kagurazaka 1 3, Shinjuku ku, Tokyo 162 8601, Japan
J Pept Sci 15:832-41. 2009..In this study, we focused our attention on the zinc-binding motif of the metzincin clan family, HEXXHXXGXXH; this family contains the general zinc-binding sequence His-Glu-Xaa-Xaa-His (HEXXH) and the ..
- Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophilaKristina A Archer
Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
Infect Immun 78:2477-87. 2010..Rip2 and Naip5/NLRC4 signaling was found to contribute to the innate immune response generated against L. pneumophila in the lung...
- Dexamethasone-associated cross-linked actin network formation in human trabecular meshwork cells involves β3 integrin signalingMark S Filla
Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, USA
Invest Ophthalmol Vis Sci 52:2952-9. 2011....
- "When the obvious brother is not there": political and cultural contexts of the orphan challenge in northern UgandaChristopher Oleke
Centre for International Health University of Bergen, Armauer Hansens Building, N 5021 Bergen, Norway
Soc Sci Med 61:2628-38. 2005..but rather by marginalised widows, grandmothers or other single women receiving little support from the paternal clan. This transition is partly linked to an abrupt discontinuation of the Langi 'widow inheritance' (laku) practice...
- The cytochrome P450 (CYP) gene superfamily in Daphnia pulexWilliam S Baldwin
Clemson University, Biological Sciences, Institute of Environmental Toxicology, Pendleton, SC, USA
BMC Genomics 10:169. 2009..The latter form a critical component of detoxification systems...
- Role of loop structures of neuropsin in the activity of serine protease and regulated secretionTakuya Oka
Division of Structural Cell Biology and Division of Structural Biology, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara, Japan
J Biol Chem 277:14724-30. 2002Neuropsin involved in neural plasticity in adult mouse brain is a member of the S1 (clan SA) family of serine proteases and forms characteristic surface loops surrounding the substrate-binding site (Kishi, T., Kato, M., Shimizu, T...
- The many selves of social insectsDavid C Queller
Department of Ecology and Evolutionary Biology, Mail Stop 170, Rice University, Post Office Box 1892, Houston, TX 77251 1892, USA
Science 296:311-3. 2002..Transfer of these odors within the colony obscures separate clan identities...
- Expression and characterization of cathepsin PRobert W Mason
Department of Biomedical Research, Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19803, USA
Biochem J 378:657-63. 2004The mouse genome contains a family of clan C1A proteases that appear to be restricted to rodents within Eutherian (placental) mammals. mRNA analysis has shown that these genes are expressed exclusively in placenta...
- Structure of a class II TrmH tRNA-modifying enzyme from Aquifex aeolicusElizabeth Pleshe
Department of Chemistry and Biochemistry, University of Colorado, Campus Box 215, Boulder, CO 80309 0215, USA
Acta Crystallogr Sect F Struct Biol Cryst Commun 61:722-8. 2005..The protein reveals a fold typical of members of the SpoU clan of proteins, a subfamily of the alpha/beta-knot superfamily, with alpha-helical extensions at the N- and C-termini ..
- Probing nature's knots: the folding pathway of a knotted homodimeric proteinAnna L Mallam
Chemistry Department, Cambridge, UK
J Mol Biol 359:1420-36. 2006..Members of the alpha/beta-knot clan form deep trefoil knots in their native backbone structure, a topological feature that is currently unexplained in ..
- The carbohydrate-binding module family 20--diversity, structure, and functionCamilla Christiansen
VKR Research Centre Pro Active Plants, Department of Plant Biology and Biotechnology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
FEBS J 276:5006-29. 2009..The clear evolutionary relatedness of CBM20s to CBM21s, CBM48s and CBM53s suggests a common clan hosting most of the known SBDs...
- Structure, expression and function of Allomyces arbuscula CDP II (metacaspase) geneMukti Ojha
Department of Biochemistry, University of Geneva, Sciences II, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
Gene 457:25-34. 2010..shown that the protein belongs to a newly described member of caspase superfamily protein, the metacaspase, a CD clan of C14 family cysteine protease, we hence-forth name it as AMca 2 (Allomyces metacaspase 2)...
- Arthropod CYPomes illustrate the tempo and mode in P450 evolutionR Feyereisen
UMR1301 INRA CNRS Universite de Nice Sophia Antipolis, 400 Route des Chappes, 06903 Sophia Antipolis, France
Biochim Biophys Acta 1814:19-28. 2011..Mitochondrial clan P450s are a monophyletic group of genes that has seen several blooms in insects, but apparently not in vertebrates.
- Neighborhood rough set reduction-based gene selection and prioritization for gene expression profile analysis and molecular cancer classificationMei Ling Hou
Intelligent Computing Laboratory, Hefei Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui, China
J Biomed Biotechnol 2010:726413. 2010..Comparison with other methods such as PAM, ClaNC, Kruskal-Wallis rank sum test, and Relief-F, our method shows that only few top-ranked genes could achieve higher ..
- Consolidation of glycosyl hydrolase family 30: a dual domain 4/7 hydrolase family consisting of two structurally distinct groupsFranz J St John
University of Maryland, School of Pharmacy, Department of Pharmaceutical Sciences, Baltimore, MD, USA
FEBS Lett 584:4435-41. 2010..For this CAZy family of Clan A enzymes the dual domain fold is conserved, suggesting that it may be a requirement for evolved function...
- Snake venom metalloproteinases: structure, function and relevance to the mammalian ADAM/ADAMTS family proteinsSoichi Takeda
Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Fujishiro dai, Suita, Osaka, Japan
Biochim Biophys Acta 1824:164-76. 2012..and ADAMTS (ADAM with thrombospondin type-1 motif) family of proteins and, together with them, constitute the M12B clan of metalloendopeptidases...
- N3 call types produced long-term by a killer whale of the northern resident community under controlled conditions: Characteristics, variation, and behavioral contextJuliette S Nash
Dept of Mar and Env Sci, Univ of San Diego, 5998 Alcala Park, San Diego, CA 92110
J Acoust Soc Am 130:2358. 2011A-Clan of the Northern Resident killer whale (Orcinus orca) community produces a dialect of discrete stereotyped vocalizations, including N3, a call found in all pods of the clan...
- A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicansJeffrey Tomalka
Center for Global Health and Diseases, Case Western Reserve University, School of Medicine, Cleveland, Ohio, United States of America
PLoS Pathog 7:e1002379. 2011..Here we show that mucosal expression of NLRP3 and NLRC4 is induced by Candida infection, and up-regulation of these molecules is impaired in NLRP3 and NLRC4 deficient ..
- Biochemical regulation of the inflammasomeJennifer K Dowling
Inflammation Research Group, School of Biochemistry and Immunology, Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
Crit Rev Biochem Mol Biol 47:424-43. 2012..Here, we review current knowledge surrounding the biochemical regulation of the NLRP1, NLRP3, NLRC4, AIM2 and IFI16 inflammasomes.
- The recombinant prepro region of TvCP4 is an inhibitor of cathepsin L-like cysteine proteinases of Trichomonas vaginalis that inhibits trichomonal haemolysisRosa Elena Cárdenas-Guerra
Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional CINVESTAV IPN, Av IPN 2508, Col San Pedro Zacatenco, Delg Gustavo A Madero, CP 07360 Mexico, DF, Mexico
Int J Biochem Cell Biol 59:73-83. 2015..TvCP4 contains the prepro fragment and the catalytic triad that is typical of the papain-like CP family of clan CA...
- AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3Adam Denes
Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, 1083, Hungary Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom and
Proc Natl Acad Sci U S A 112:4050-5. 2015..Here, using a rodent model of stroke, we show that the NLRC4 (NLR family, CARD domain containing 4) and AIM2 (absent in melanoma 2) inflammasomes contribute to brain injury...
- Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in Lung DiseaseSeonmin Lee
1 Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Am J Respir Cell Mol Biol 54:151-60. 2016..e., NLR family, pyrin domain containing [NLRP] 1, NLRP3, and NLR family, caspase recruitment domain containing-4 [NLRC4]) as well as the pyrin and hemopoietic expression, interferon-inducibility, nuclear localization domain-containing ..
- The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome ActivationXiaowei Wang
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Infect Immun 84:1796-805. 2016..loop 2 of sialostatin L2, an anti-inflammatory tick protein, binds to annexin A2 and impairs the formation of the NLRC4 inflammasome during infection with the rickettsial agent Anaplasma phagocytophilum Macrophages deficient in ..
- Involvement of the NLRC4-Inflammasome in Diabetic NephropathyFang Yuan
Department of Nephrology, The Second Xiangya Hospital, Research Institute of Nephrology, Central South University, Changsha, Hunan China
PLoS ONE 11:e0164135. 2016..In an effort to understand other IL-1β activating mechanism during DN development, we examined the role of the NLRC4-inflammasome in DN and found that NLRC4 is a parallel mechanism, in addition to the NLRP3-inflammasome, to induce ..
- Association of Inflammasome Components in Background Liver with Poor Prognosis After Curatively-resected Hepatocellular CarcinomaFuminori Sonohara
Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
Anticancer Res 37:293-300. 2017..Inflammasomes are multiprotein complexes that evoke key inflammatory cascades. The present study evaluated the influence of inflammasome component expression in non-tumorous tissue on postsurgical hepatocellular carcinoma (HCC) prognosis...
- Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosisB J Geddes
Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
Biochem Biophys Res Commun 284:77-82. 2001..A novel human member of this family, called CARD12, was identified that induces apoptosis when expressed in cells...
- Vocal clans in sperm whales (Physeter macrocephalus)L E Rendell
Department of Biology, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada
Proc Biol Sci 270:225-31. 2003..Units seem to form groups preferentially with other units of their own clan. We suggest that this is a rare example of sympatric cultural variation on an oceanic scale...
- Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogensS J Sanderson
Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Joseph Black Building, Glasgow G12 8QQ, UK
FEBS Lett 542:12-6. 2003..Recombinant forms of each ICP inhibit protozoan and mammalian clan CA, family C1 cysteine peptidases but do not inhibit the clan CD cysteine peptidase caspase 3, the serine peptidase ..
- Gingipains, the major cysteine proteinases and virulence factors of Porphyromonas gingivalis: structure, function and assembly of multidomain protein complexesJan Potempa
Department of Microbiology, Faculty of Biotechnology, Jagiellonian University, 30 387 Krakow, Poland
Curr Protein Pept Sci 4:397-407. 2003..evolutionary related to other highly specific proteinases including clostripain, caspases, legumains and separase (clan CD of cysteine peptidases)...
- PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1Yetao Wang
Center for the Development of Molecular Target Drugs, Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
Int Immunol 16:777-86. 2004..IL-1beta maturation, and it does so in the presence and absence of constitutively active mutants of CARD12 and PYPAF1, which are enhancers of these processes. Thus, PYNOD is a novel regulator of apoptosis and inflammation.
- The fourth level of social structure in a multi-level society: ecological and social functions of clans in hamadryas baboonsAmy L Schreier
Department of Evolutionary Anthropology, Duke University, Durham, North Carolina 27708, USA
Am J Primatol 71:948-55. 2009..All band fissions occurred along clan lines, and most takeovers involved the transfer of females within the same clan...
- The structure of DinB from Geobacillus stearothermophilus: a representative of a unique four-helix-bundle superfamilyDavid R Cooper
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
Acta Crystallogr Sect F Struct Biol Cryst Commun 66:219-24. 2010..The structural similarities of these diverse proteins suggest that a new Pfam clan encompassing the families that share this fold should be created...
- Crystal structure and mutational analysis of aminoacylhistidine dipeptidase from Vibrio alginolyticus reveal a new architecture of M20 metallopeptidasesChin Yuan Chang
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 30010, Taiwan
J Biol Chem 285:39500-10. 2010..4.13.3) belong to the family of M20 metallopeptidases from the metallopeptidase H clan that catalyze a broad range of dipeptide and tripeptide substrates, including L-carnosine and L-homocarnosine...
- Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenologTheodoros Goulas
Proteolysis Lab, Department of Structural Biology, Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Cientificas, Barcelona Science Park, Helix Building, E 08028 Barcelona, Spain
Proc Natl Acad Sci U S A 108:1856-61. 2011..is active against several protein substrates and its structure reveals a new family prototype within the metzincin clan of metallopeptidases...
- Structural and kinetic insights reveal that the amino acid pair Gln-228/Asn-254 modulates the transfructosylating specificity of Schwanniomyces occidentalis β-fructofuranosidase, an enzyme that produces prebioticsMiguel Alvaro-Benito
Centro de Biologia Molecular Severo Ochoa, Departamento de Biologia Molecular, Universidad Autónoma de Madrid Consejo Superior de Investigaciones, Cantoblanco, 28049 Madrid, Spain
J Biol Chem 287:19674-86. 2012..The results contribute to an understanding of the molecular basis regulating specificity among GH-J clan members, which represent an interesting target for rational design of enzymes, showing redesigned activities to ..
- Spontaneous formation of IpaB ion channels in host cell membranes reveals how Shigella induces pyroptosis in macrophagesL Senerovic
Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Chariteplatz 1, D 10117 Berlin, Germany
Cell Death Dis 3:e384. 2012..These data may explain how S. flexneri uses secreted IpaB to escape phagosome and kill the host cells during infection and, may be extended to homologs from other medically important enteropathogenic bacteria...
- Caregiving of children with intellectual disabilities in China--an examination of affiliate stigma and the cultural thesisM Y L Chiu
Department of Social Work, National University of Singapore, Singapore
J Intellect Disabil Res 57:1117-29. 2013..There is little literature on caregivers in China, where familial and clan responsibility rather than individual effort is emphasised, and where communal support, while treasured, is often ..
Research Grants58
- Discovery metabolite profiling of the prolyl peptidasesAlan Saghatelian; Fiscal Year: 2009..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
- Gabriel Nunez; Fiscal Year: 2015..NLR family members including NOD1, NOD2, NLRC4 and NLRP3 are intracellular proteins that are involved in the recognition of microbial components and activation ..
- Molecular mechanisms of pathogen recognition by the Nod-like receptor NLRC4Fayyaz S Sutterwala; Fiscal Year: 2012..aeruginosa are required. In this proposal we will examine the role of the NOD-like receptor (NLR) family member NLRC4 in recognition and response to infection with P. aeruginosa...
- Gabriel Nunez; Fiscal Year: 2016..The activation of caspase-1 is controlled by members of the intracellular NOD-like receptor (NLR) family including NLRC4 and NLRP3...
- Samithamby Jeyaseelan; Fiscal Year: 2016..We have previously shown the NLR family CARD domain containing 4 (NLRC4;IPAF) as a new sensor to K...
- Shawn J Skerrett; Fiscal Year: 2016..This aim will test the hypothesis that muted function of the NLRC4 inflammasome underlies the susceptibility of human AM to parasitism by Lp...
- Sanjay Batra; Fiscal Year: 2016..and human alveolar macrophages as well as murine lungs;3) as compared to other NLRs (NOD1, NOD2, NLRP1, NLRP3, and NLRC4), NLRP12 activation leads to much higher production of IL-1[unreadable], IL-18 and IL-17 in murine lungs following ..
- Role of caspases in Legionella pneumophila pulmonary infectionAmal O Amer; Fiscal Year: 2013..pneumophila with the exception of mice lacking Ipaf, caspase-1 or harboring a mutant Naip5 gene...
- Igor E Brodsky; Fiscal Year: 2014..Activation of inflammasomes by Salmonella involves sensing of bacterial flagellin by NLRC4, and sensing of an unknown bacterial signal by NLRP3...
- How can caspases control intracellular pulmonary pathogensAmal O Amer; Fiscal Year: 2010..Whereas most mouse strains are resistant to Legionella with the exception of the A/J, caspase-1-/- and Ipaf-/- mice...
- Edward A Miao; Fiscal Year: 2016..Some NLRs, including NLRP3 and NLRC4, form inflammasomes that recruit and activate Caspase-1, a protease that subsequently cleaves the inflammatory ..
- Pulmonary Pathogen-Recognition Pathways in MelioidosisTIMOTHY EOIN WEST; Fiscal Year: 2013..innate and adaptive immunity;and 3) to determine the related role of the cytosolic ICE-protease-activating factor (IPAF)/caspase-1 signaling axis in melioidosis. In performing these studies, Dr. West will be closely supervised by Dr...
- Russell E Vance; Fiscal Year: 2016..To address these questions, our studies have focused on a sub-family of inflammasomes called the Naip/Nlrc4 inflammasomes...
- Yeast-based HTS Assay Technologies for ProteasesJohn C Reed; Fiscal Year: 2012..in which compounds will be identified and optimized that selectively inhibit the upstream Caspase-1 activator NLRC4 (Ipaf1;CLAN), a component of innate immunity and critical regulator of host responses to intracellular bacterial ..
- Craig R Roy; Fiscal Year: 2015..Host pattern recognition system controlled by the adapter proteins MyD88, Rip2, NLRC4, and Naip5 have been shown to trigger innate immune responses to L. pneumophila...
- Listeria-based vaccines engineered to modulate the innate immune systemDaniel A Portnoy; Fiscal Year: 2011..inflammasome, while another strain secretes an ActA-flagellin (ActA-Fla) fusion protein and activates a NLRC4-dependent inflammasome...
- Control of intestinal microflora and inflammation by immune sensing of flagellinJanelle S Ayres; Fiscal Year: 2012..mouse mutants deficient for the function of two flagellin-sensing proteins of the innate immune response, Naip5 and Ipaf, were found to be resistant to colitis compared to wild type mice...
- The role of NALPs in innate immunityFayyaz S Sutterwala; Fiscal Year: 2010..2) Determining how NALPS and IPAF can direct the activity of caspase-1 towards cytokine processing and/or cell death...
- ANDREW T KENT; Fiscal Year: 2015..Here we will look at two members of this family of receptors, NLRC4 (also known as IPAF) and NAIP5, which are known to synergize with ASC for pro-inflammatory signaling in response ..
- Zuni MI/CRA ProjectKamilla L Venner; Fiscal Year: 2010..tribal communication norms, and CRA is particularly well suited to make use of the extended family and unique clan structure of reservation life...
- Organizational Culture's Impact Across the Nursing Home IndustryJane Banaszak Holl; Fiscal Year: 2009..four scale variables that measure the intensity of four types of values defined by the CVF: market, hierarchical, clan and adhocratic values, where clan- oriented values are those most strongly associated with the culture change ..
- Role of Ipaf in Inflammation and Host DefenseGabriel Nunez; Fiscal Year: 2009..b>Ipaf is another NOD family member highly related to NOD1 and NOD2...
- Development of a High-Throughput Assay for Human Desumoylating Enzymes [SENPs]Guy Salvesen; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): The human peptidase clan CE is defined by seven proteases with a common fold and catalytic mechanism, commonly known as SENPs (sentrin specific proteases - sentrin being an alternative ..
- CHILDES 91: WORKSHOP ON AUTOMATED TRANSCRIPT ANALYSISCatherine Snow; Fiscal Year: 1991..in CHAT, the system transcription manual), and c) a set of programs for manipulating and analyzing transcript data (CLAN, which stands for Child Language Analysis)...
- Arthritis Research Conference 2005Gregg Silverman; Fiscal Year: 2005..abstract_text> ..
- RHEUMATIC DISEASES CORE CENTERGregg Silverman; Fiscal Year: 2006..An Administrative Core (PI-G.J. Silverman, Center Director) will provide overall direction and supervision to all Center programs through an Executive Committee, which will be assisted by an Outside Advisory Committee. ..
- alpha4beta1 Intergrin Signaling In Immunity And ArthritisGREGG JOSHUA SILVERMAN; Fiscal Year: 2010..Collectively, this work will provide insight into the role of the ct4-paxillin interaction in inflammation and immunity, and whether this interaction is a potential bona fide therapeutic target for arthritis. ..
- Cell Death and Antibody-Mediated Protection from AutoimmunityGREGG JOSHUA SILVERMAN; Fiscal Year: 2010....
- Mechanisms to Induce Protective Natural AutoimmunityGregg Silverman; Fiscal Year: 2004..abstract_text> ..
- B CELL SUPERANTIGENS AND IMMUNE REGULATIONGregg Silverman; Fiscal Year: 2008..In addition, these studies will lead to a better understanding of the immunobiologic activities of a virulence factor from one of the most important causes of life-threatening infection in the US. ..
- Arthritis Research Conference 2007Gregg Silverman; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Ipaf signaling in innate immunityEDWARD MIAO; Fiscal Year: 2008..In this proposal we will focus on Ipaf, a Nod/Nalp family member. Ipaf activates NF-KappaB and Caspase 1 in immune cells...
- CONTROLS FOR ASSOCIATION STUDIES OF ALCOHOLISMKenneth Kidd; Fiscal Year: 2009..Indications of the importance to alcoholism of different genetic variants and of which haplotypes may harbor cryptic but functionally relevant variation will result from these studies. ..
- Autophagy in TuberculosisVOJO P DERETIC; Fiscal Year: 2011..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..
- MECHANISM OF INTERFERON ACTIONCHARLES SAMUEL; Fiscal Year: 2009..Furthermore, elucidation of the actions of IFN at the molecular level is of importance in view of potential applications of interferon in the clinic. ..
- PEPTIDE SYNTHESIZERSherwin Wilk; Fiscal Year: 2001..The instrument will be operated and maintained by Dr. Imre Wolf, an accomplished peptide chemist and instrumentation specialist who has operated the Mount Sinai Core facility Milligen peptide synthesizer. ..
- Induction of breast cancer in MMTVneu miceWilliam Baldwin; Fiscal Year: 2002..Overall, the purpose of this study is to examine 4-nonylphenol's effects on breast cancer growth and its mechanism of action on the mammary tumor. ..
- BIOSYNTHESIS OF BETA LACTAM ANTIBIOTICSCraig Townsend; Fiscal Year: 2003..These insights will be extended to examination of beta- lactam formation in the prephytotoxin tabtoxin. ..
- EVALUATION OF FALCIPAIN AS AN ANTIMALARIAL DRUG TARGETPhilip Rosenthal; Fiscal Year: 2003..This evaluation is also likely to identify specific falcipain inhibitors with potent antimalarial activity that will be ready for initial testing against human malaria. ..
- Nod1: An Apaf-like Activator of Apoptosis and NF-kBNaohiro Inohara; Fiscal Year: 2005..We propose three Specific Aims to understand the biochemical mechanism by which bacterial LPS and Nod1 interact and to determine the role of Nod1 in the response to bacterial LPS in vivo. ..
- Falcipain Cysteine Proteases of Malaria ParasitesPhilip Rosenthal; Fiscal Year: 2005..Experiments designed to accomplish these aims should improve our understanding of the biology of malaria parasites and aid in the characterization of falcipains as potential drug targets. ..
- Hyperacidification and Pseudomonas infections in CFVojo Deretic; Fiscal Year: 2006..abstract_text> ..
- BRAIN ENDOPEPTIDASES AND NEUROPEPTIDE METABOLISMSherwin Wilk; Fiscal Year: 2001....
- 400 MHz NMR Spectrometer for Shared UseCraig Townsend; Fiscal Year: 2004..9) investigation of the hypothesis that aromatic amino acids are required to specify a distinct conformational state by NMR spin relaxation techniques, to elucidate important parameters for protein design. ..
- The Type III Pathway of Yersinia PestisOlaf Schneewind; Fiscal Year: 2004..Together these studies are also aimed at identifying molecular targets for drug therapies, an important area of research to aid in the defense against biological warfare and bioterrorist deployment of the select agent Y. pestis. ..
- Innate Immune Detection of Intracellular PathogensRUSSELL VANCE; Fiscal Year: 2005....
- Modulation of Host Cell Functions by Coxiella burnetiiCraig R Roy; Fiscal Year: 2010..These studies will elucidate pathogenic determinants that allow host cell infection by Coxiella and reveal intracellular infection strategies employed by this important pathogen. ..
- Pseudomonas in Cystic Fibrosis-Regulation of MucoidyVojo Deretic; Fiscal Year: 2006..These studies are expected to improve our understanding of respiratory pathogenesis in CF, and lead to new treatments of presently incurable lung infections associated with this disease...
- Interaction of Yersinia with dendritic cellsIgor Brodsky; Fiscal Year: 2007..This knowledge will be important in the development of future strategies against human pathogens. ..
- DEVELOPING AN ISRAELI VERSION OF THE HRS/SHARE PROJECTHoward Litwin; Fiscal Year: 2006..abstract_text> ..
- Innate immune resistance to intracellular bacterial pathogensRUSSELL VANCE; Fiscal Year: 2007..Naip5 exhibits homology to a large family of cytosolic pathogen-detector proteins that also includes Ipaf, Nods and Nalps...
- Archiving the Data from the First Wave of SHARE-IsraelHoward Litwin; Fiscal Year: 2007..The data address key economic and social factors that contribute to health among people 50 years of age and older, providing unique opportunities for cross-national comparisons. [unreadable] [unreadable] [unreadable] [unreadable]..
- LINKAGE DISEQUILIBRIUM AND HUMAN GENETIC STUDIESKenneth Kidd; Fiscal Year: 2008..The data will be made publicly available through ALFRED, an existing Web-accessible database. ..
- Mechanism of M. tuberculosis Phagosome Maturation ArrestVojo Deretic; Fiscal Year: 2008..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection. ..
- LcrV Plague Vaccine with Altered Immune Modulatory PropertiesOlaf Schneewind; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Clinical & Molecular Studies of Drug Resistant MalariaPhilip Rosenthal; Fiscal Year: 2008..abstract_text> ..
- Resistance of Malaria Parasites to Artemisinin-Based Combination TherapiesPhilip Rosenthal; Fiscal Year: 2008..abstract_text> ..


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Bulgaria's specialised anti-corruption unit has charged former Foreign Minister Daniel Mitov with violating the laws on public finance and public procurement, a notice on the prosecutor's office said on May 9.
Mitov is one of several ministers from the right-wing Reformist Bloc - a former coalition partner of the ruling Citizens for European Development of Bulgaria (GERB) - to be charged in recent months. New Prime Minister Boyko Borissov has pledged to continue the fight against corruption in Bulgaria, one of the most corrupt countries in the EU according to Transparency International.
Mitov did not call a public procurement for air transport, hotel accommodation and health insurance for official trips by foreign ministry officials. Instead, he used a company the ministry of agriculture and food had selected through a public procurement procedure.
Prosecutors claim the foreign ministry suffered damages of BGN494,458 (€252,812) in additional money paid because the contractor allegedly did not fulfil its pricing offer. Previously, Mitov's deputy Hristo Angelichin was also charged in the same case.
However, Mitov claims that the contractor returned the overpaid money to both ministries after a check, Dnevnik daily reported.
In the previous regular government, Daniel Mitov served as a cabinet member from the quota of the junior ruling coalition partner Reformist Bloc. This was the second government led by the centre-right GERB under Borissov. GERB's third government, this time a coalition with the United Patriots, took office on May 4.
Previously, prosecutors have charged two other Reformist Bloc ministers in separate cases. On November 21, then outgoing Health Minister Petar Moskov was indicted over the exchange of vaccines between Bulgaria and Turkey. On January 16, the Sofia city prosecutor's office filed an indictment with the Sofia city court against then outgoing Defence Minister Nikolay Nenchev over his alleged failure to ensure aviation safety and the airworthiness of Bulgarian fighter aircraft.
Bulgarian state-owned gas transmission system operator Bulgartransgaz and Macedonian energy company MER Skopje have signed an agreement on the start of a ... more
CEFC, the acquisitive Chinese energy group, and Penta Investments, the closely-held Slovak financial group, are bidding together for Time Warner's stake in Central European Media Enterprises (CME), ... more
Bulgaria's government will allow the construction of a second ski lift in the Bansko ski resort, but will demand a double ... more


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Ordering books for Christmas?
Complete your order no later than Monday 11th December to ensure they get to you in time!
Sonali Deraniyagala was born and raised in Colombo, Sri Lanka. She has an undergraduate degree in Economics from Cambridge University and a doctorate in Economics from the University of Oxford. She is on the faculty of the Department of Economics at SOAS, University of London and is a research scholar at Columbia University, New York City. She lives in New York, and North London.


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text:
Free Food for Merit Students
from Poor Families: We are looking
for donors to donate generously to help providing free
food to merit students to continue their studies and
achieve excellent results. More...
Items Donation:
Donors can donate any items or materials which are required
for the hostel. Please contact Chief Warden J. Satyanarayana
Reddy or any of the present governing body members to find
out the items required for the hostels.
Contact numbers for donations are given in Contact
Us page.


text:
Alumni and Families
As lifelong members of your Greek organizations, there are opportunities to remain active no matter where you live. No matter how long it has been since you were involved, you are always welcome back to our community.
Additionally, as family members of a current Greek student, we want to provide resources to connect you with our chapters. We know Greek Life can appear like a mystery to those not involved, but we hope to provide you with a window into our community to create a better overall understanding.
Below are a few ways to keep connected with our current Greek community:
- UWEC Greek Newsletter - Keep up to date with a monthly newsletter about each active chapter, the programs and initiatives coordinated by the Panhellenic and Interfraternity Councils, recruitment efforts, learn about the Greek student of the month, and more!
- Greek Alumni Weekend - Attend a variety of events designed for all alumni and guests over Homecoming weekend!
- Family Welcome Letter - Read our welcome letter to introduce you to our Greek community.
- Suggest an Event - Want to see an event happen on campus? Tell us what you would like to see to help keep you connected!
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Closing out the busy month of August and leaping into an even busier September, please celebrate with us the release of Sheila Squillante's new chapbook, In This Dream of My Father. Number 2.09 in our Editor's Series, with gorgeous cover art by Paul Bilger. Here's the shortlink:
Category Archives: Editor's Series
R.J. Gibson, You Could Learn a Lot
Mistakes with Strangers launches today
Mistakes with Strangers, the new chapbook by Jeff Oaks, is officially published today! Number 7 in Volume Two of our Editor's Series and hot on the heels of A.V. Christie's The Wonders, which came out July 1, we (I) are (am) folding, cutting, and sewing a big ol' batch of preordered copies–thank you, everyone!–and will have all those out by this weekend. Then it's a merry-go-round assembly of several titles by Steven Alvarez, Christina Pacosz, Kevin McLellan, Christina Hutchins, Will Woolfitt, Dave Bonta, Heather Burns, Jeffery Ethan Lee. . . you get the picture: we need volunteers/ interns/ elves. If anyone knows anyone in the area who'd like to help assemble chapbooks and talk poetry, drop me a line (ron dot mohring at gmail dot com). And thank you, thank you all, for helping Seven Kitchens hang together through seven years and sixty (!) chapbooks.
David Eye: Rain Leaping Up When a Cab Goes Past
The newest release in our Editor's Series, David Eye's chapbook is here at last. Read a sample poem and order your copy here.
Ed Madden, My Father's House: Kickstarter campaign success
Just checked in on the Kickstarter campaign to support the November 7 performance of Ed Madden's My Father's House set to music by Paddy Dover: the campaign has met its $3500 goal and is still going strong! Please help support this unique event.
Ed Madden – My Father's House – pre-order yours!
We're so happy to announce the imminent release of Ed Madden's My Father's House (Editor's Series #2.04) on April 21. Help us celebrate Ed's beautiful poems by pre-ordering your copy now!
Breakfast in the Suburbs by David J. Daniels
It's out! Breakfast in the Suburbs by David J. Daniels is officially published today, and you can read about it and order your copy right here.


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Prayers of a One Man Band [LP] - VINYL
- Artist: Bobby Brown
- Release Date: 01/06/2017
Cardmember Offers
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- The Boy a Sailor
- Steamboat Mama
- Sail On
- Lady Tennessee
- Jungle Cowboy
- Hawaii Nei I'll Miss You
- The Peaceful Ko 'Olaus
- My Dog the Outlaw
- If the Angels Cry
- Sweet Clean Air
- I'm Bolieve
- The Cry of the Wild
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