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2U, Inc. (TWOU) CMO Harsha Mokkarala Sells 22,658 Shares
2U, Inc. (NASDAQ:TWOU) CMO Harsha Mokkarala sold 22,658 shares of the firm's stock in a transaction dated Friday, November 10th. The shares were sold at an average price of $63.25, for a total transaction of $1,433,118.50. Following the completion of the transaction, the chief marketing officer now directly owns 47,869 shares in the company, valued at $3,027,714.25. The sale was disclosed in a document filed with the SEC, which is available at this link.
2U, Inc. (TWOU) opened at $63.72 on Tuesday. The company has a quick ratio of 3.48, a current ratio of 3.48 and a debt-to-equity ratio of 0.05. 2U, Inc. has a 12 month low of $29.23 and a 12 month high of $65.90.
2U (NASDAQ:TWOU) last released its earnings results on Tuesday, November 7th. The software maker reported ($0.15) earnings per share for the quarter, topping the Zacks' consensus estimate of ($0.16) by $0.01. 2U had a negative net margin of 12.49% and a negative return on equity of 13.02%. The business had revenue of $70.25 million for the quarter, compared to analyst estimates of $69.36 million. During the same period last year, the company posted ($0.06) EPS. The business's revenue was up 35.1% on a year-over-year basis. research analysts expect that 2U, Inc. will post -0.62 EPS for the current year.
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A number of brokerages recently weighed in on TWOU. Robert W. Baird raised their price target on shares of 2U from $49.00 to $59.00 and gave the company an "outperform" rating in a research note on Tuesday, August 8th. Needham & Company LLC raised their price target on shares of 2U from $66.00 to $72.00 and gave the company a "buy" rating in a research note on Wednesday, November 8th. BMO Capital Markets raised their price target on shares of 2U from $68.00 to $70.00 and gave the company an "outperform" rating in a research note on Wednesday, November 8th. BidaskClub lowered shares of 2U from a "strong-buy" rating to a "buy" rating in a research note on Friday, August 11th. Finally, Credit Suisse Group reaffirmed an "outperform" rating and issued a $70.00 price target (up from $64.00) on shares of 2U in a research note on Wednesday, November 8th. One research analyst has rated the stock with a hold rating, ten have given a buy rating and one has given a strong buy rating to the company's stock. 2U currently has a consensus rating of "Buy" and an average target price of $62.73.
Institutional investors and hedge funds have recently added to or reduced their stakes in the business. Zurcher Kantonalbank Zurich Cantonalbank increased its holdings in shares of 2U by 182.2% during the 2nd quarter. Zurcher Kantonalbank Zurich Cantonalbank now owns 2,622 shares of the software maker's stock worth $123,000 after buying an additional 1,693 shares during the last quarter. Ameritas Investment Partners Inc. increased its holdings in shares of 2U by 21.4% during the 2nd quarter. Ameritas Investment Partners Inc. now owns 3,844 shares of the software maker's stock worth $180,000 after buying an additional 677 shares during the last quarter. Rehmann Capital Advisory Group acquired a new stake in shares of 2U during the 2nd quarter worth approximately $204,000. Principal Financial Group Inc. acquired a new stake in shares of 2U during the 1st quarter worth approximately $208,000. Finally, Advisor Group Inc. increased its holdings in shares of 2U by 41.5% during the 2nd quarter. Advisor Group Inc. now owns 4,476 shares of the software maker's stock worth $210,000 after buying an additional 1,313 shares during the last quarter. 98.31% of the stock is currently owned by institutional investors and hedge funds.
2U Company Profile
2U, Inc is a provider of an integrated solution consisting of cloud-based software-as-a-service (SaaS) combined with technology-enabled services (together, the Platform) that allows colleges and universities to deliver online degree programs. The Company's SaaS technology consists of a learning environment (Online Campus), which acts as the hub for all student and faculty academic and social interaction, and a suite of integrated applications, which the Company uses to launch, operate and support the Company's clients' programs.
Receive News & Ratings for 2U Inc. Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for 2U Inc. and related companies with MarketBeat.com's FREE daily email newsletter.


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My Revision Notes: CCEA ICT for GCSE
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About the Author
Other Formats
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96 pages
Siobhan Matthewson, Gerry Lynch, Margaret Debbadi
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Hodder Education
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Sulphur Granular
Sulphur: Sulphur is the 10th most abundant element in the Milky Way Galaxy. It is found in the earth's crust, in the ocean and even in meteorites. 55 percent of Sulphur is used in the production of Fertilizer. 45 percent is used in producing commercial products. Sulphur is found in foods - onions, eggs, cauliflower, and soybean flour. Sulphur is found in humans, chickens, and sheep. Sulphur is used in matches and fireworks because it burns easily. Its ancient name "brimstone" means "the stone that burns".
Sulphur is a non-metallic chemical element identified by the letter S. Sulphur is a valuable commodity and integral component of the world economy used to manufacture numerous products including fertilizers and other chemicals.Sulphur also is a vital nutrient for crops, animals and people.
Attributes Specification Colour - Bright yellow Shape - Pastilles Total moisture % - 0.5% max Ash content % - 0.05% Max Acidity as sulphuric acid% - 0.05% Max Purity % - 99.5% min
Product: silicon dioxide ( quartz ) sio2 82% Origin: nigeria Quantity: 97.156 tons ( 97156 kg ) Loading port: lagos / nigeria Discharge port: cif Inspection: bureau veritas test report at loading port already done Chemical components: Sio2 82% Cu 2.75% Pb 0.057% Zn 0.004% As 0.4ppm Cd
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Portable ventilation fan. With swith and integrated plastic handle Provide plug with 2.5 metres wire Heat zinc immersion plate surfac Portable industrial fan Features 1.Large air volume 2.Low noise 3.High voltage 4.Get ce ccc Applications 1.It can be widely used in complex environment such as food , medicine, metallurgy, power plants , transportation and so on. 2.In strict accordance with the production requirements of explosion-proof electric motors, our company has produce this fan so that its insulation class up to grade f. 3.And our company has enhanced the sealing performance of electric motors through the shell and technological improvements. For this reason , under such relatively humid or high-temperature circumstance can this product be available. Characteristics This portable or moveable axial blower has a beautiful overall appearance. The size 200mm-350mm is easily to take by a handle, the size bigger than 350mm can set wheels, so that can make it easily to move. This series blowers habe high pressure, stable electrical performance, and it can be connerct for post telecommunications, and underground cable repairing tunnel poject.
Metallic and non metallic materials.
Sulphur, granule sulphur, lump sulphur, sulfur, lump sulfur, granule sulfur, fine powder sulphur, fine powder sulfur.International transportation
Sulfur or sulphur (British English; see spelling below) is a chemical element with symbol S and atomic number 16. It is an abundant, multivalentnon-metal. Under normal conditions, sulfur atoms form cyclic octatomic molecules with chemical formula S8. Elemental sulfur is a bright yellowcrystalline solid when at room temperature. Chemically, sulfur can react as either an oxidant or reducing agent. It oxidizes most metals and severalnonmetals, including carbon, which leads to its negative charge in most organosulfur compounds, but it reduces several strong oxidants, such asoxygen and fluorine. Sulfur occurs naturally as the pure element (native sulfur) and as sulfide and sulfate minerals. Elemental sulfur crystals are commonly sought after by mineral collectors for their distinct, brightly colored polyhedron shapes. Being abundant in native form, sulfur was known in ancient times, mentioned for its uses in ancient India, ancient Greece, China and Egypt. Fumes from burning sulfur were used as fumigants, and sulfur-containing medicinal mixtures were used as balms and antiparasitics. Sulfur is referred to in the Bible as brimstone (burn stone) in English, with this name still used in several nonscientific tomes.[3] It was needed to make the best quality of black gunpowder. In 1777, Antoine Lavoisier helped convince the scientific community that sulfur was a basic element, rather than a compound. Elemental sulfur was once extracted from salt domes where it sometimes occurs in nearly pure form, but this method has been obsolete since the late 20th century. Today, almost all elemental sulfur is produced as a byproduct of removing sulfur-containing contaminants from natural gas andpetroleum. The element's commercial uses are primarily in fertilizers, because of the relatively high requirement of plants for it, and in the manufacture of sulfuric acid, a primary industrial chemical. Other well-known uses for the element are in matches, insecticides and fungicides. Many sulfur compounds are odoriferous, and the smell of odorized natural gas, skunk scent, grapefruit, and garlic is due to sulfur compounds.Hydrogen sulfide produced by living organisms imparts the characteristic odor to rotting eggs and other biological processes.
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The silicon carbide(sic) heating element is a kind of non~metal high temperature electric heating element. It is made of selected super quality green silicon carbide as main material , which is made into blank, solid under high temperature and re~crystallized. Compared with metal electric heating element, this element is characterized by high~applied temperature , anti~oxidization, anti~corrosion, long service life, little deformation, easy installation and maintenance. Therefore , it is widely used in various high temperature electric furnaces and other electric heating devices, such as in the Industries of magnet, ceramics, powder metallurgy, glass, metallurgy and machinery etc. All the specifications can be made according to your requirements. And our technical engineers are pleased to assist you! There are ed(rod) type?u type?w(three phase)type?g(gun)type?db(dumbbell)type?scr(double spiral)type?sc(single spiral)type?h type for you to choose.
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Pirate FM News
Keep up to date with the latest news delivered direct to your Inbox.
AUDIO: Bude Surfer Speaks Out Over Viral Video
2:36pm 3rd April 2014
(Updated 2:36pm 3rd April 2014)
A Bude surfer whose Go-Pro video went viral after he was sworn at and told in no uncertain terms to get 'back to England' speaks out.
Thousands have watched a paddle boarder lay into Phil Brown after he shared a wave.
The 29 year old says he is worried it has made Cornwall look bad: "Fair enough yes I did want an apology in the first place but I had no idea that this would escalate in this manner and I just want to shake the guys hand and just let it all go and apologise really.
"I'd like to think now that this isn't something that happens in Bude at all. This is the first incidence that I've encountered of it and I've lived here my whole life. People shouldn't be put off by coming to Bude just because of something that's caught on and gone viral that has no reflection on the place or on Cornish people or even on Liverpudlians either. Perhaps he was just having a bad day.
"If he does happen to listen to this then I am more than happy for him to come and find me or contact Pirate FM and shake my hand and we can both apologise. I hope that nobody shares anything else on Facebook. Please just let it die down. I want it to stop now before it goes any further."
Hear his full interview here:
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VIDEO: Historic sex offences against children rocket
The number in Devon and Cornwall has almost trebled
PHOTOS: Cornish pub speaks out after firework incident
An investigation's being carried out into what happened
At least two people seriously injured in A38 crash
It scrambled police, fire crews and air ambulance
Death of young man at Cornish recycling plant
Police are making enquiries at the site in Redruth
BREAKING: Body of woman found in Truro
Cornwall News: Police are treating the death as unexplained
Pirate FM Cornwall News Update - 7th January 2016
Cornwall Video News: Officials say they're holding talks to find new jobs for hundreds of workers in Bodmin.
EU 'ready for ambitious' trade deal amid warning for City on banking passport
National News: The EU's chief negotiator has said the bloc is "ready" to offer Britain an "ambitious" free trade deal - but the UK will lose one of the advantages currently enjoyed by the City.
UPDATE: Body found on popular Cornish beach
Cornwall News: Police say death at Watergate Bay 'isn't suspicious'
Harrison Ford becomes real-life hero as he helps to rescue woman after crash in California
Showbiz News: Harrison Ford has once again shown his real-life hero credentials after helping to rescue a woman following a car crash in California.
German president calls for all parties to reconsider position
World News: Germany's president has urged all parties to reconsider their positions and compromise, hours after coalition talks collapsed.
Donald Trump calls for Oakland Raiders' Marshawn Lynch to be suspended
Sports News: Donald Trump has called for Oakland Raiders' Marshawn Lynch to be suspended in a fresh row over protests during the USA national anthem.
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text:
174.55 KB, message/rfc822
11 years ago
User-Agent: Mozilla/5.0 (Windows; U; Windows NT 5.1; en-US; rv:188.8.131.52) Gecko/20061204 Firefox/220.127.116.11 Build Identifier: version 2 beta 2 (20070116) I get a daily HTML newsletter (dealnews.com) for which I set TB to allow loading remote images automatically for this sender. In TB 1.5 while the message was loading (it did take a little bit) I could still scroll up and down in the message window, using the mouse wheel. In TB 2 beta 2 the entire TB hangs, it doesn't respond at all until the entire message is loaded. I use a SOCKS proxy for outgoing connections, if that makes a difference. This seems to be a regression from TB 1.5 Reproducible: Always Steps to Reproduce: 1. Get a large HTML message (e.g. dealnews.com newsletter) 2. Click on the message 3. While the message is loading, TB2 hangs, it doesn't respond to the mouse wheel. Regression from TB 1.5
Comment 1•
11 years ago
Could you attach a test message (save as .eml).
Created attachment 255334 [details]
sample HTML email on which TB hangs for me
Here's the message attached, but if I open it from my desktop it's fast and it doesn't load any of the images ... It may need to be moved into an (IMAP) Inbox to see the problem.
If not, you could just sign up for the dealnews.com daily newsletter - don't worry, you won't get spammed and you can get off their mailing list. Of course, you could also use some sort of a disposable email address too, but one that doesn't mess with the HTML ...
Comment 3•
11 years ago
-> NEW on Mozilla/5.0 (X11; U; Linux i686; en-US; rv:22.214.171.124pre) Gecko/20070217 Thunderbird/2.0pre ID:2007021703 Forwarded the attached mail to my imap account. Thunderbird doesn't hang, but e.g. trying to scroll the folder pane doesn't really work while the msg is loading. Thunderbird is very sluggish and doesn't respond very well. Don't see this with a recent 1.5.0.x nightly.
OK, I'm glad someone else can confirm the regression from 1.5.0.x Hopefully we will see a fix for this in time for TB2 final.
Comment 5•
11 years ago
attachment 255334 [details] is an excellent testcase. the images load serially. could this be part of the problem? plus maybe reflow? probable duplicates: bug 380713 bug 379828 - in this bug, per reporter disabling phishing isn't a great improvement bug 369345 might be related, but it's different in that reporter sees problem for both html and what he calls "plain text"
10 years ago
10 years ago


text:
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Charles Dickens : World of His Novels
List price: US$3.23
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Product details
- Paperback | 346 pages
- 127 x 195.58 x 27.94mm | 430.91g
- 01 Jun 1969
- Bloomington, United Kingdom
- 0253201241
- 9780253201249
Review Text
This is a study of the artist's consciousness rather than the artist himself and, in following the progression of his novels, follows the development of Dickens' imagination, his changing vision of things as the real world is translated into this imaginative world. The discussion centers around each book, with sometimes a grouping acting as a bridge to the next publication: ?? Papers, Oliver Twist: Nicholas Nickleby and The Old Curiosity Shop and Bar??by Rudge: Marlin Chuzzlewit; Dombey and Son; David Copperfield; Bleak House, Hard Times and Little Dorrit and A Tale of Two Cities: Our Mutual Friend; Great Expectations, and The Mystery of Edwin Drood, are examined minutely, precisely, for their literal expressions of the pattern that went from Victorian picaresque to the theme of the outcast who searches "for status and authentic identity" so that he may "escape through his own efforts". Bleak House is here judged to be the "watershed peak of Dicken's career" in which the act of will is effected, while Little Dor?? is accisimed as his finest work along with Our Mutual Friend. This is an exacting dissertion of primary interest to Dickens' scholars rather than to his fonder readers who may feel that, while the operation is successful, the patient dies. (Kirkus Reviews)show more


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Set of 60 Jungle Animal Counters by Learning Resources
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Take your child on an early math safari with these beautifully detailed exotic animal counters. The set of 60 includes five different species, with 12 members each, that kids can count, sort, and group to make patterns. An imaginative way to learn basic skills with numbers, sorting, and classifying, this set also helps to stir interest in unusual creatures from distant lands. From Learning Resources.
- Includes 60 animal counters, animal fun facts, and reusable storage bucket
- Ages 3 to 10
- Made in China
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Set of 60 Jungle Animal Counters by Learning Resources is rated out of 5 by 3.
Rated 4 out of 5 by Nan from Yes, they're REALISTIC! I received this free product as part of an incentivized review program. I use the animals with special needs children for activities including counting, sorting, and same/different. I appreciate that the animals are realistic in color and anatomy such that, while my 10-11 year old students are still working at basic skill levels, they can use realistic figures rather than cartoon-like or preschool type animals. They have high interest in the animals included. For several weeks, I was unaware that the label inside the container was actually a fold-out brochure. Discovering this, I was then impressed that the brochure included facts about each animal. Each time I open the container, I am momentarily halted by a strong almost chemical smell from the plastic figures, but this has not stopped me from using the product.
Date published: 2017-10-28
Rated 4 out of 5 by Art Teacher Kristen from Counting and Play fun I received this product as part of an incentivised review program. I used the pieces in my classroom for observation drawing of animals. It is great since I studnets can see all of the sides of the animals without the actual animal being there. It is much better than looking at a photograph and copying it. I also have used them as counters with my 5 year old nephew. He loves animals and while playing with the animals we are able to get some counting and estimating in too.
Date published: 2017-10-18
Rated 5 out of 5 by Linda from Great for Kindergarten Will be using in my Kindergarten classroom. Students love making pretend zoos by building with blocks. It helps to have so many animals to help them share. Also use them to have students sort the animals--to find similarities and differences such as which animals have stripes or which animals are grey.
Date published: 2017-07-06


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By Christian Louter, Freek Bos, Jan Belis, Jean-Paul Lebet
This complaints quantity of the difficult Glass four & rate motion TU0905 ultimate convention, held 6-7 February 2014 on the EPFL in Lausanne, Switzerland, represents the ultimate motion ebook of the eu examine community price motion TU0905 "Structural Glass – Novel layout equipment and subsequent new release products". It includes approximately a hundred peer-reviewed papers – released through greater than one hundred eighty authors from 22 assorted nations – that concentrate on the architectural and structural functions of glass in constructions and facades. As such, it offers a profound cutting-edge of structural glass layout and engineering. A must-read for all architects, engineers, scientists, companions and different lovers attracted to this quickly evolving and demanding area.
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Casadei F. , Experimental and numerical investigations of laminated glass subjected to blast loading. International Journal of Impact Engineering, 39:42–50, 2012. Peroni M. , Pizzinato V. , Experimental investigation of high strain-rate behaviour of glass. Applied Mechanics and Materials, 82:63–68, 2011. , Parametric study of laminated glass window response to blast loads. Engineering Structures, 56:1707 – 1717, 2013. EN 1998-1:2005, Eurocode 8: Design of structures for earthquake resistance - Part 1: General rules, seismic actions and rules for buildings.
Commonly, the panes are heterogeneously exposed to solar radiation. Consequently, the central part of the pane will try to expand, while the parts concealed within the frame will try to withstand this expansion (Figure 1). Because of this phenomenon, the tensile stresses will increase in the cold part which is in general the glass edge. Glass breakage will occur when this stress exceeds the local glass edge strength. 11 Figure 1. Principle of thermal breakage (TV 214, 1999). g. the climate combined with the façade orientation, the geometry and composition of the façade, the presence of shade on a part of the glazing, the presence of sun shades or curtains etc.
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Question about Dell Latitude D610 Laptop Computer - Intel Pentium M 750 1.86GHz, 802.11b/g Wireless, 1G PC Notebook
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Do you know how many people in my family are born in April? Lots. And then we did the whole Easter thing. And that is why I am 1,000 words short of my goal of 30k, which I meant to meet Sunday. Oh well! When I am a paid writer working with important deadlines, I won't let things like birthdays or Easter or autoharps or blog entries or really good television shows get in the way of my career!
Ha ha ha!
Belinda Stronach is leaving politics. I'm pretty bummed out about this because I really enjoyed telling people she was Stronach enough to be my Prime Minister and now she is denying herself the chance to run the country and, more importantly, me the chance to make a small fortune off that slogan. Even though I'm pretty sure I picked it up from someone cleverer than me. But that doesn't matter. What matters is who makes and profits off the t-shirts first.
Anyway, thanks a lot, Belinda.
In all seriousness, I don't blame her for stepping down. She had to suffer through Peter MacKay's moping after their break-up because oh my God, she had policital convictions–ps: tackiest photo-op EVER, Peter–never mind the truly heinous name calling she endured later on. Not cool, Tories. Not cool at all. See, this is why I never vote for you.
Well, that and your con$ervative value$.


text: Headfirst Into the Deep End http://headfirstintothedeepend.typepad.com/blog/ It's about writing and other stuff. en-US 2017-11-21T10:43:57-08:00 Writing the first draft: I'm doing it all wrong. Or am I? http://headfirstintothedeepend.typepad.com/blog/2017/11/writing-the-first-draft.html The consensus among writers who are far more accomplished than me—i.e., those who know the "correct" method of writing a first draft—is that you plow through and finish the stupid, shitty thing, and worry about revisions when it comes time to launch your first round of edits. Yet this has never worked for me. Books Thomas Bradley 2017-11-21T10:43:57-08:00 You wonder when it will happen here. http://headfirstintothedeepend.typepad.com/blog/2017/10/you-wonder-when-it-will-happen-here.html But in what way, in any possible way, can your change be any more tangible, more horrific, than it has for the loved ones of those lost and those who somehow—through determination or sheer luck or, if you believe in such things, divine intervention—survived the onslaught? Current Affairs Thomas Bradley 2017-10-03T11:12:49-07:00 I Love My #NFL! http://headfirstintothedeepend.typepad.com/blog/2017/09/i-love-my-nfl.html But fall—there's no need for further introduction. The air turns crisp and the leaves turn…well, in most places that aren't here…brilliant shades of red, orange, and yellow. Scorching hot days give way to pleasant nights, and artificial pumpkin flavor reigns supreme almost everywhere food and drink are sold. Food and Drink Games Sports Television Thomas Bradley 2017-09-19T14:39:31-07:00 Bill and the Hot Chicks: A Remembrance http://headfirstintothedeepend.typepad.com/blog/2017/09/bill-and-the-hot-chicks.html Perhaps, I reasoned, there was a middle ground to Bill's tales. Perhaps he had, indeed, seduced some young women of varying degrees of hotness. Who were we to say for sure one way or the other? Current Affairs History Weblogs Thomas Bradley 2017-09-13T14:45:54-07:00 An Audience of One: Writing to Please Yourself http://headfirstintothedeepend.typepad.com/blog/2017/08/an-audience-of-one-writing-to-please-yourself.html They're literary legends with loyal followings and I'm just some pipsqueak nobody who learned how to self-publish my crap even when nobody asked me to. Books Weblogs Thomas Bradley 2017-08-18T11:56:00-07:00


text:
Research Topics
Genomes and Genes
Gene Symbol: chico
Description: CG5686 gene product from transcript CG5686-RB
Alias: BcDNA.GH11263, BcDNA:GH11263, CG5686, CHICO, Chico, Dmel\CG5686, IRS, IRS/chico, anon-WO0078940.1, anon-WO0078940.4, chic, dIRS, fs(2)4, fs(2)ry4, CG5686 gene product from transcript CG5686-RB, CG5686-PA, CG5686-PB, CG5686-PC, chico-PA, chico-PB, chico-PC, flipper, insulin receptor substrate, insulin-like receptor substrate
Species: fruit fly
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications105 found, 100 shown here
- The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eyeJ R Riesgo-Escovar
Zoologisches Institut, Universitat Zurich, Switzerland
Genes Dev 10:2759-68. 1996..Although DJNK efficiently phosphorylates DJun in vitro, bsk function is not required for the specification of cell fate in the developing eye, a process that requires MAP kinase and DJun function...
- Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4R Bohni
Zoologisches Institut, Universitat Zurich, Switzerland
Cell 97:865-75. 1999The control of growth is fundamental to the developing metazoan. Here, we show that CHICO, a Drosophila homolog of vertebrate IRS1-4, plays an essential role in the control of cell size and growth...
- PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye developmentH Huang
Howard Hughes Medical Institute and Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06536 0812, USA
Development 126:5365-72. 1999....
- Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathwayD C Goberdhan
Research School of Biosciences, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
Genes Dev 13:3244-58. 1999..to the Drosophila Class I phosphatidylinositol 3-kinase, Dp110, and its upstream activator Chico, an insulin receptor substrate homolog...
- Measuring dimensions: the regulation of size and shapeS J Day
28 St Oswalds Road, York, YO10 4PF, UK
Development 127:2977-87. 2000..We discuss a hypothesis that the local steepness of a morphogen gradient is a measure of length in one axis, a measure that is used to determine whether there will be net growth or not...
- Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycinS Oldham
Zoologisches Institut, Universitat Zurich, 8057 Zurich, Switzerland
Genes Dev 14:2689-94. 2000..These results are consistent with dTOR residing on a parallel amino acid sensing pathway...
- Genetic control of size in DrosophilaS Oldham
Zoological Institute, University of Zurich, Switzerland
Philos Trans R Soc Lond B Biol Sci 355:945-52. 2000..In this article we will review recent evidence from vertebrates and particularly from Drosophila that implicates insulin/insulin-like growth factor-I and other growth pathways in the control of cell, organ and body size...
- Stem cells and their progeny respond to nutritional changes during Drosophila oogenesisD Drummond-Barbosa
Howard Hughes Medical Institute Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland 21210, USA
Dev Biol 231:265-78. 2001....
- Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate proteinD J Clancy
Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
Science 292:104-6. 2001The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway...
- dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1Thomas Radimerski
Friedrich Miescher Institute, Novartis Research Foundation, Maulbeerstrasse 66, 4058 Basel, Switzerland
Nat Cell Biol 4:251-5. 2002..Effectors of this pathway include Chico (the insulin receptor substrate homologue), dPI(3)K, dPKB, dPTEN, and dS6K...
- Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKBHugo Stocker
Zoologisches Institut der Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Science 295:2088-91. 2002..Thus, Akt appears to be the only critical target activated by increased PIP3 concentrations in Drosophila...
- Dietary restriction in long-lived dwarf fliesDavid J Clancy
Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
Science 296:319. 2002
- The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levelsSean Oldham
Universitat Zurich, Zoologisches Institut, Winterthurerstrasse 190, CH 8057, Switzerland
Development 129:4103-9. 2002..We show that in Drosophila mutating the consensus binding site for the Ras pathway adaptor Drk/Grb2 in Chico/IRS does not interfere with growth whereas mutating the binding sites of the PI 3-kinase adaptor p60 completely ..
- Insulin/IGF and target of rapamycin signaling: a TOR de force in growth controlSean Oldham
The Burnham Institute, La Jolla, CA 92037, USA
Trends Cell Biol 13:79-85. 2003..This review summarizes current studies primarily from Drosophila regarding the function of the insulin/IGF system in the control of growth...
- The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chicoMeng Ping Tu
Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, USA
Aging Cell 1:75-80. 2002..this sex-difference, we conducted a large-scale demographic study with three new isogenic strains of alleles at chico, the insulin-receptor substrate homologue...
- The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signalingMartin A Jünger
Zoologisches Institut, Universitat Zurich, Winterthurerstr, 190, CH 8057 Zurich, Switzerland
J Biol 2:20. 2003..In this study, we present a genetic characterization of dFOXO, the only Drosophila FOXO ortholog...
- Juvenile diet restriction and the aging and reproduction of adult Drosophila melanogasterMeng Ping Tu
Department of Ecology and Evolutionary Biology, Box G W, Brown University, Providence, RI 02912, USA
Aging Cell 2:327-33. 2003..Homozygotes of insulin-like receptor (InR) and insulin-like receptor substrate (chico) delay time to eclosion, reduce body size, decrease reproduction and increase life span...
- Tuberous sclerosis complex: from Drosophila to human diseaseDuojia Pan
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
Trends Cell Biol 14:78-85. 2004..Here, we review these exciting developments with an emphasis on Drosophila studies and discuss how Drosophila can be a powerful model system for an understanding of the molecular mechanisms of the activity of human disease genes...
- Insulin regulation of heart function in aging fruit fliesRobert J Wessells
The Burnham Institute, Center for Neuroscience and Aging, 10901 Torrey Pines Road, La Jolla, California 92037, USA
Nat Genet 36:1275-81. 2004..systemic levels of insulin-like peptides are reduced and by mutations of the only receptor, InR, or its substrate, chico. Moreover, interfering with InR signaling exclusively in the heart, by overexpressing the phosphatase dPTEN or the ..
- Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogasterAmmon B Corl
Department of Anatomy and Programs, University of California, San Francisco, California 94143 2822, USA
Nat Neurosci 8:18-9. 2005..These findings suggest a previously unknown role for this highly conserved pathway in regulating the behavioral responses to an addictive drug...
- The plasticity of aging: insights from long-lived mutantsCynthia Kenyon
Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
Cell 120:449-60. 2005..Many mutations affecting longevity pathways delay age-related disease, and the molecular analysis of these pathways is leading to a mechanistic understanding of how these two processes--aging and disease susceptibility--are linked...
- Sex and death: what is the connection?Linda Partridge
UCL Centre for Research on Ageing, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom
Cell 120:461-72. 2005..Understanding the molecular basis of the cost of reproduction will be informed by elucidation of the mechanisms by which DR and IIS affect these two traits...
- Calorie restriction--the SIR2 connectionLeonard Guarente
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Cell 120:473-82. 2005....
- Susi, a negative regulator of Drosophila PI3-kinaseFranz Wittwer
Zoologisches Institut, Universitat Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
Dev Cell 8:817-27. 2005..The fact that Susi is expressed in a circadian rhythm, with highest levels during the night, suggests that Susi attenuates insulin signaling during the fasting period...
- The temporal requirements for insulin signaling during development in DrosophilaAlexander W Shingleton
Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA
PLoS Biol 3:e289. 2005..We hypothesize that the insulin-signaling pathway controls such diverse effects as total developmental time, total body size and organ size through its effects on the rate of cell growth, and proliferation in different organs...
- Signaling and function of insulin-like peptides in insectsQi Wu
Department of Cellular Biology, University of Georgia, Athens
Annu Rev Entomol 51:1-24. 2006....
- TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activityQian Yang
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 103:6811-6. 2006..Our observations suggest that TSC1/2 and Rheb have different effects on the activity of TORC1 and -2, further supporting the complexity of TOR regulation...
- Foxo and Fos regulate the decision between cell death and survival in response to UV irradiationXi Luo
Department of Biology, University of Rochester, Rochester, NY 14627, USA
EMBO J 26:380-90. 2007..These data suggest that integrating stress and survival signals through Foxo drives the decision between cell death and repair of damaged cells in vivo...
- Dynamics of the action of dFOXO on adult mortality in DrosophilaMaria E Giannakou
Centre for Research on Ageing, Department of Biology, University College London, London, UK
Aging Cell 6:429-38. 2007..The decreased mortality and increased lifespan of dFOXO overexpressing flies was uncoupled from any effect on female fecundity and from expression levels of Drosophila insulin-like peptides in the brain...
- Quantitative proteomic analysis of protein complexes: concurrent identification of interactors and their state of phosphorylationDelphine Pflieger
Institute for Molecular Systems Biology, ETH, 8093 Zurich, Switzerland
Mol Cell Proteomics 7:326-46. 2008..of samples immunopurified from Drosophila melanogaster cells expressing an epitope-tagged form of the insulin receptor substrate homologue Chico...
- Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in DrosophilaHwei Jan Hsu
Department of Cell and Developmental Biology, 4120B Medical Research Building III, Vanderbilt University Medical Center, 465 21st Avenue South, Nashville, TN 37232 8240, USA
Dev Biol 313:700-12. 2008..Moreover, the retained ability of GSC tumors to respond to diet parallels the long known connections between diet, insulin signaling, and cancer risk in humans...
- Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistanceBasil Honegger
Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
J Biol 7:10. 2008..In mammals, insulin-like growth factor binding proteins (IGFBPs) bind IGFs with high affinity and modulate their mitogenic, anti-apoptotic and metabolic actions, but no functional homologs have been identified in invertebrates so far...
- Tissue damage-induced intestinal stem cell division in DrosophilaAlla Amcheslavsky
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell Stem Cell 4:49-61. 2009..By using this newly established system of intestinal stem cell proliferation and tissue regeneration, we find that the insulin receptor signaling pathway is required for intestinal stem cell division...
- Insulin levels control female germline stem cell maintenance via the niche in DrosophilaHwei Jan Hsu
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232 8240, USA
Proc Natl Acad Sci U S A 106:1117-21. 2009..These results underscore the importance of systemic factors for the regulation of stem cell niches and, thereby, of stem cell numbers...
- Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogasterSergey V Nuzhdin
Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA
BMC Genomics 10:124. 2009..We focus on the latter problem by describing genetic variation in transcript levels of genes in the InR/TOR pathway among 72 Drosophila melanogaster genotypes...
- Quantification of food intake in DrosophilaRichard Wong
Institute of Healthy Ageing, and GEE, University College London, London, UK
PLoS ONE 4:e6063. 2009..that alterations in food intake are not induced by dietary restriction or by a null mutation of the fly insulin receptor substrate chico...
- The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathwayChristian Werz
Institute of Molecular Systems Biology, Zurich, Switzerland
PLoS Genet 5:e1000596. 2009..phosphoinositide 3-kinase (PI3K) in the IIS cascade, at the same level as chico (encoding the single fly insulin receptor substrate [IRS] homolog)...
- Molecular mechanisms of metabolic regulation by insulin in DrosophilaAurelio A Teleman
German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Biochem J 425:13-26. 2009..I discuss both the intracellular signalling network, as well as the communication between organs in the fly...
- Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogasterIvana Bjedov
Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, UK
Cell Metab 11:35-46. 2010..Rapamycin could increase life span of weak insulin/Igf signaling (IIS) pathway mutants and of flies with life span maximized by dietary restriction, indicating additional mechanisms...
- SH2B regulation of growth, metabolism, and longevity in both insects and mammalsWei Song
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Cell Metab 11:427-37. 2010..Here, we identified dSH2B as the Drosophila homolog of SH2B1. dSH2B bound to Chico and directly promoted insulin-like signaling...
- Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signalingLutz Kockel
Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 6:e1000990. 2010..These results illustrate how the Akt-TOR pathway dynamically adapts the routing of negative feedback in response to the activity load of its signaling circuit in vivo...
- Lifespan extension by preserving proliferative homeostasis in DrosophilaBenoit Biteau
Department of Biology, University of Rochester, Rochester, New York, USA
PLoS Genet 6:e1001159. 2010....
- dFOXO-independent effects of reduced insulin-like signaling in DrosophilaCathy Slack
Institute of Healthy Ageing and GEE, University College London, Gower Street, London, UK
Aging Cell 10:735-48. 2011....
- Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespanRochele Yamamoto
Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
Aging Cell 10:729-32. 2011..Here, we conduct genetic epistasis analysis to determine whether foxo is required for chico mutants (insulin receptor substrate) to reduce age-specific mortality and thus extend lifespan...
- Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathwayNa Hyun Choi
Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
Proc Natl Acad Sci U S A 108:18702-7. 2011..These results suggest that ISCs can indirectly sense changes in nutrient and insulin levels through contact with their daughters and reveal a mechanism that could link physiological changes in tissue growth to stem cell proliferation...
- Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteomeTimo Glatter
Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
Mol Syst Biol 7:547. 2011..Subsequent genetic studies in flies suggest a role for dTTT in controlling cell growth via a dTORC1- and dTORC2-dependent mechanism...
- Mutations in the Drosophila insulin receptor substrate, CHICO, impair olfactory associative learningShintaro Naganos
Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan
Neurosci Res 73:49-55. 2012CHICO, the Drosophila homolog of vertebrate insulin receptor substrate (IRS), mediates insulin/insulin-like growth factor signaling (IIS), and reductions in chico severely disrupt cell growth and proliferation...
- Slow aging during insect reproductive diapause: why butterflies, grasshoppers and flies are like wormsM Tatar
Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
Exp Gerontol 36:723-38. 2001..elegans daf-2. We propose neuroendocrine control of reproductive diapause in D. melanogaster that includes phenotypic plasticity for rates of senescence...
- Insulin signaling is necessary for vitellogenesis in Drosophila melanogaster independent of the roles of juvenile hormone and ecdysteroids: female sterility of the chico1 insulin signaling mutation is autonomous to the ovaryDavid S Richard
Department of Biology, Susquehanna University, Selinsgrove, PA 17870, USA
J Insect Physiol 51:455-64. 2005..However, female sterility of an insulin/IGF-like signaling mutant (chico(1)) of D...
- Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restrictionSergiy Libert
Program in Cell and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, N820, Houston TX, 77030, United States
Mol Immunol 45:810-7. 2008..system in Drosophila carrying the longevity extending mutations puc (JNK signaling pathway, stress response) and chico (insulin signaling pathway), as well as animals subjected to dietary restriction (DR), which also extends lifespan...
- The carboxyl terminal extension of the Drosophila insulin receptor homologue binds IRS-1 and influences cell survivalM Marin-Hincapie
Department of Anatomy and Cell Biology, State University of New York, Health Science Center, Brooklyn, New York 11203, USA
J Biol Chem 274:24987-94. 1999..INR beta-Myc co-immunoprecipitated a phosphoprotein of 170 kDa identified as insulin receptor substrate-1 (IRS-1), whereas INR betaDelta did not, suggesting that the site of interaction was within the ..
- Mitochondria, oxidants, and agingRobert S Balaban
Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Maryland 20892, USA
Cell 120:483-95. 2005..Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging...
- Tissue-specific coupling between insulin/IGF and TORC1 signaling via PRAS40 in DrosophilaCristina Pallares-Cartes
German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Dev Cell 22:172-82. 2012..Finally, this work sheds some light on the question of whether TORC1 activity is coupled to IIS in vivo...
- Insulin signaling mediates sexual attractiveness in DrosophilaTsung Han Kuo
Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, United States of America
PLoS Genet 8:e1002684. 2012..These results suggest that the activity of conserved molecular regulators of longevity and reproductive output may manifest in different species as external characteristics that are perceived as honest indicators of fitness potential...
- Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in musclesKushal K Banerjee
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India
Mol Cell Biol 33:252-64. 2013..In summary, we show that fat body dSir2 is a master regulator of organismal energy homeostasis and is required for maintaining the metabolic regulatory network across tissues...
- The drosophila T-box transcription factor midline functions within Insulin/Akt and c-Jun-N terminal kinase stress-reactive signaling pathways to regulate interommatial bristle formation and cell survivalQ Brent Chen
The Department of Biological Sciences, USM, USA
Mech Dev 136:8-29. 2015....
- The insulin-regulated CREB coactivator TORC promotes stress resistance in DrosophilaBiao Wang
Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USA
Cell Metab 7:434-44. 2008..As disruption of insulin signaling also augmented TORC activity in adult flies, our results illustrate the importance of an insulin-regulated pathway that functions in the brain to maintain energy balance...
- The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signalingJustin R DiAngelo
The Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 106:20853-8. 2009..These data suggest that communication between these two regulatory systems evolved as a means to divert energy in times of need from organismal growth to the acute requirement of combating infection...
- Comparative transcriptional profiling identifies takeout as a gene that regulates life spanJohannes Bauer
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
Aging (Albany NY) 2:298-310. 2010..behavior and juvenile hormone binding is also increased in four other life span extending conditions: Rpd3, Indy, chico and methuselah...
- The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in DrosophilaYuzuru Imai
Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
PLoS Genet 6:e1001229. 2010..These results suggest that PGAM5 negatively regulates the PINK1 pathway related to maintenance of the mitochondria and, furthermore, that PGAM5 acts between PINK1 and Parkin, or functions independently of Parkin downstream of PINK1...
- Molecular population genetics of the insulin/TOR signal transduction pathway: a network-level analysis in Drosophila melanogasterDavid Alvarez-Ponce
Departament de Genetica, i Institut de Recerca de la Biodiversitat, Universitat de Barcelona, Barcelona, Spain
Mol Biol Evol 29:123-32. 2012..The detected polarity would be, therefore, intrinsic to the IT pathway architecture and function...
- A cytogenetic analysis of chromosomal region 31 of Drosophila melanogasterN J Clegg
Department of Zoology, University of British Columbia, Vancouver, Canada
Genetics 134:221-30. 1993..In addition, the cytological position of several mutations that interact with heterochromatin were more precisely defined...
- A JNK signal transduction pathway that mediates morphogenesis and an immune response in DrosophilaH K Sluss
Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA
Genes Dev 10:2745-58. 1996..These data demonstrate that the DJNK signal transduction pathway mediates an immune response and morphogenesis in vivo...
- The latest in signal transduction, 1999. Specificity in Signal Transduction, Keystone, Colorado, USA, 9-14 April 1999E Spana
Department of Genetics, Howrd Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
Trends Genet 15:301-2. 1999
- The genetic control of organ growth: insights from DrosophilaD Weinkove
Department of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, 1066 CX, The Netherlands
Curr Opin Genet Dev 10:75-80. 2000..Furthermore, the role of Drosophila homologues to human tumour suppressor genes and oncogenes in imaginal disc growth has been investigated...
- Characterization of Drosophila insulin receptor substrateR M Poltilove
Diabetes Branch, NIDDKD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 275:23346-54. 2000b>Insulin receptor substrate (IRS) proteins are phosphorylated by multiple tyrosine kinases, including the insulin receptor...
- Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathwaysJ C Clemens
Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 0606, USA
Proc Natl Acad Sci U S A 97:6499-503. 2000..We also show that Drosophila AKT (DAKT) activation depends on the insulin receptor substrate, CHICO (IRS1-4)...
- Genetic control of cell sizeH Stocker
Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
Curr Opin Genet Dev 10:529-35. 2000..Evidence is emerging for a signalling cascade conserved in evolution that links external nutrient sources to cell size...
- Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growthF Wittwer
Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Development 128:791-800. 2001..These results suggest that Lilli acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth...
- Longevity. Growing old togetherE Strauss
Science 292:41-3. 2001
- Life span: getting the signal from the nervous systemCatherine A Wolkow
Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Trends Neurosci 25:212-6. 2002..This review examines the evidence for nervous system control of longevity and discusses the implications for popular models for aging...
- Insulin receptor-mediated organ overgrowth in Drosophila is not restricted by body sizeDeborah C I Goberdhan
Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
Dev Genes Evol 212:196-202. 2002..Given the evolutionarily conserved role of insulin receptor signalling in growth control, our data may also help to explain why this pathway is so frequently hyperactivated in mammalian tumours...
- A Drosophila melanogaster cell line (S2) facilitates post-genome functional analysis of receptors and ion channelsPaula R Towers
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, UK
Bioessays 24:1066-73. 2002..In addition, many useful orthologues of human disease genes are emerging from the Drosophila genome and the study of their functions and interactions is another area for postgenome applications of S2 cell lines...
- Molecular genetics of aging in the fly: is this the end of the beginning?Stephen L Helfand
Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030 3301, USA
Bioessays 25:134-41. 2003....
- A small issue addressedTina L Gumienny
Department of Molecular Biology and Chemistry, Waksman Institute, Cancer Institute of New Jersey, Rutgers University, Piscataway, NJ 08854 8020, USA
Bioessays 25:305-8. 2003..elegans, the TGFbeta-like pathway acts in the hypodermis to regulate cell size and consequently body size.1 This finding is an exciting step in discovering the molecular mechanisms that control cell and body size...
- Development. Wiring the brain with insulinBarry J Dickson
Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna, Austria
Science 300:440-1. 2003
- Axons guided by insulin receptor in Drosophila visual systemJianbo Song
Brookdale Department for Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
Science 300:502-5. 2003..DInR functions as a guidance receptor for the adapter protein Dock/Nck. This function is independent of Chico, the Drosophila insulin receptor substrate (IRS) homolog.
- Genetics of aging in the fruit fly, Drosophila melanogasterStephen L Helfand
Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030 3301, USA
Annu Rev Genet 37:329-48. 2003....
- Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogasterA J Hulbert
Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
Exp Gerontol 39:1137-43. 2004..Thus, individual variation in lifespan in wild-type flies, and life extension by dietary-restriction and reduced insulin/IGF-1 signalling is not attributable to differences in metabolic rate...
- DNA methyltransferase gene dDnmt2 and longevity of DrosophilaMeng Jau Lin
Institute of Molecular Medicine, National Taiwan University, Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan, Republic of China
J Biol Chem 280:861-4. 2005..The study links the Drosophila DNA methylation program with the small heatshock proteins and longevity/aging and has interesting implication on the eukaryotic DNA methylation programs in general...
- Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of HedgehogSatomi Takeo
Department of Biology, Tokyo Metropolitan University, Hachioji shi, Tokyo 192 0397, Japan
Dev Biol 284:204-18. 2005..These findings support the recently proposed model that secreted glypicans have opposing and/or distinct effects on morphogen signaling from the membrane-tethered forms...
- Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life historyThomas Flatt
Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
Bioessays 27:999-1010. 2005..In particular, we illustrate the role of JH as a key mediator of life history trade-offs...
- Drosophila lacking microRNA miR-278 are defective in energy homeostasisAurelio A Teleman
European Molecular Biology Laboratory, 69117 Heidelberg, Germany
Genes Dev 20:417-22. 2006..We provide evidence that miR-278 mutants are insulin resistant and that miR-278 acts through regulation of the expanded transcript...
- Age-independent synaptogenesis by phosphoinositide 3 kinaseAlfonso Martín-Peña
Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
J Neurosci 26:10199-208. 2006..Thus, we propose that PI3K stimulation can be applied to prevent or delay synapse loss in normal aging and in neurological disorders...
- Contribution of growth and cell cycle checkpoints to radiation survival in DrosophilaBurnley Jaklevic
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309 0347, USA
Genetics 174:1963-72. 2006..or onset of pupariation) or inhibition of growth factor signaling and downstream targets (by mutations in cdk4, chico, or dmyc) reduced the radiation survival of larvae...
- Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophyHalyna R Shcherbata
Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA
EMBO J 26:481-93. 2007..Importantly, we now report that Dg interacts with insulin receptor and Nck/Dock SH2/SH3-adaptor molecule in photoreceptor path-finding. This is the first demonstration of a genetic interaction between Dg and InR...
- Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in DrosophilaOliver Bell
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse, Basel, Switzerland
EMBO J 26:4974-84. 2007..Thus di- and trimethylation of H3K36 have opposite effects on H4K16 acetylation, which we propose enable dynamic changes in chromatin compaction during transcript elongation...
- Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in DrosophilaSudeshna Dutta
Molecular and Cell Biology Program, University of Maryland, College Park, Maryland 20742, USA
Curr Biol 18:1466-75. 2008..Although the Warts (Wts) tumor suppressor is a critical regulator of tissue growth in animals, it is not clear how this signaling pathway controls cell growth...
- Regulation of feeding and metabolism by neuronal and peripheral clocks in DrosophilaKanyan Xu
Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cell Metab 8:289-300. 2008..We propose that the input of neuronal clocks and clocks in metabolic tissues is coordinated to provide effective energy homeostasis...
- Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in DrosophilaFabio Demontis
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Development 136:983-93. 2009..Thus, maximal dMyc transcriptional activity depends on InR to control muscle mass, which in turn induces a systemic behavioral response to allocate body size and proportions...
- Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLazJulie Hull-Thompson
Department of Biology, University of Rochester, Rochester, New York, United States of America
PLoS Genet 5:e1000460. 2009..The JNK pathway and Lipocalins are structurally and functionally conserved, suggesting that similar interactions represent an evolutionarily conserved system for the control of metabolic homeostasis...
- FOXO-dependent regulation of innate immune homeostasisThomas Becker
Development, Genetics and Molecular Physiology Unit, LIMES Institute, University of Bonn, Carl Troll Strasse 31, D 53115 Bonn, Germany
Nature 463:369-73. 2010..The sparse production of AMPs in epithelial tissues in response to FOXO may help modulating the defence reaction without harming the host tissues, in particular when animals are suffering from energy shortage or stress...
- Studies on the rate and site-specificity of P element transpositionC A Berg
Howard Hughes Medical Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
Genetics 127:515-24. 1991..During the course of these experiments, Y-linked insertions expressing rosy+ were recovered, suggesting that marked P elements can sometimes insert and function at heterochromatic sites...
- A second maternally expressed Drosophila gene encodes a putative RNA helicase of the "DEAD box" familyT de Valoir
Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77251
Proc Natl Acad Sci U S A 88:2113-7. 1991..A search for mutations in the ME31B gene has established that the P element which causes the female-sterile mutation flipper lies in the 3' flank of the ME31B gene.
- Perspectives: cell biology. All creatures great and smallS J Leevers
Ludwig Institute for Cancer Research, London, UK
Science 285:2082-3. 1999
- The beauty of small fliesC F Lehner
Nat Cell Biol 1:E129-30. 1999
- The Cold Spring Harbor Laboratory meeting on tyrosine phosphorylation and cell signaling. Cold Spring Harbor, NY, USA, May 12-16, 1999M F Roussel
Department of Tumor Cell Biology, Danny Thomas Research Tower, D5006C, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794, USA
Biochim Biophys Acta 1470:R17-20. 2000
- Do growth and cell division rates determine cell size in multicellular organisms?C M Coelho
Ludwig Institute for Cancer Research, London W1P 8BT, UK
J Cell Sci 113:2927-34. 2000..These interactions may provide a means of coordinating growth and cell division, such that cells divide only when they are above a minimum size...
- Mechanisms of size controlC J Potter
Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, Connecticut 06536 0812, USA
Curr Opin Genet Dev 11:279-86. 2001..The mechanisms of organ size control could also be critical targets for evolutionary events or disease processes such as tumorigenesis...
- The coupling of cell growth to the cell cycleN Tapon
Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
Curr Opin Cell Biol 13:731-7. 2001..This work has revealed interesting and unexpected relationships between mechanisms that regulate growth and the cell cycle machinery...
- Insulin-related peptides and their conserved signal transduction pathwayIlse Claeys
Laboratory for Developmental Physiology and Molecular Biology, K U, Leuven, Belgium
Peptides 23:807-16. 2002....
Research Grants9
- Functions and Interactions dFOXO in Drosopila AgingMarc Tatar; Fiscal Year: 2010..Flies with ubiquitous, constitutive mutations at the insulin-like receptor (InR) and insulin receptor substrate (chico) retard demographic and functional aging, Recently, dFOXO of D...
- CSF-1 RECEPTOR SIGNALLING AND G1 PROGRESSIONMartine Roussel; Fiscal Year: 2001..The identification of novel effector molecules should enable definition of regulatory networks that govern events late in G1 phase, including the commitment to enter S phase. ..
- AGING AND NEURODEGENERATIVE DISEASESCynthia Kenyon; Fiscal Year: 2006....
- Nucleotide polymorphisms responsible for expression variation in DrosophilaSergey Nuzhdin; Fiscal Year: 2009..These studies will contribute to building a pathway-minded description of complex character variation. They will shed light on the genetic architecture of transcript level variation in nature. ..
- QUANTITATIVE TRAIT LOCI RELATED TO DROSOPHILA SPECIATIONSergey Nuzhdin; Fiscal Year: 2004..This comprehensive assessment of the genetics of several traits will further our understanding of the genetics of speciation. ..
- Regulatory systems of Drosophila agingMarc Tatar; Fiscal Year: 2007..In a comprehensive experimental design, we shall assess qualifies of stress resistance, central metabolism and mitochondria function to determine which feature best predicts variance in life span [unreadable] [unreadable]..
- Genetics of Reproductive SenescenceMarc Tatar; Fiscal Year: 2010..Coupled with the program-wide multidimensional measures of somatic aging, we shall evaluate the extent that reproductive and somatic aging are concordant or independent. ..
- MOLECULAR ANALYSIS OF TRANSCRIPTIONAL ADAPTORSLeonard Guarente; Fiscal Year: 2001..Finally, a possible link between this coactivator and TBP will be investigated genetically and biochemically. ..
- LONGEVITY/CANDIDATE GENE POLYMORPHISMS IN DROSOPHILAMarc Tatar; Fiscal Year: 2003..The genotype-phenotype associations detected with this design will be of broad significance to the problem of genetic variation for longevity in general populations. ..
- In vivo insect model system for type-2 diabetesPatent Number: WO0078940-A1; Date:2000-12-28


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Khadija Saye Memorial Fund Raises Money to Support Young Artists
In the wake of 24-year-old Khadija Saye's tragic death, her mentors are seeking donations for a memorial fund that will help emerging talent.
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Q: Can you please tell me how to cancel my JPG+.
A: Do you know?


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Buy Human Hair at the best prices.
Human Hairlauralaboy58 2 hours 21 minutes ago News human hair All https://haireverywheresales.com Discuss
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Simply Only is a selected minimalism lifestyle and fashion online store with affordable price. We sell our own label and selected products in fashion, lifestyle and home with worldwide shipping.
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Hippocrates Health Institute's chiropractor specializes in the upper cervical spine and has helped our guests heal from a wide range of health issues. Upper Cervical misalignments can result from a variety of injuries including from a fall, an automobile accident, a sports injury, a bump on the head, poor posture, bad sleeping habits or even just from the birthing process.
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Re: A certain bias, there
Correct, kind of. But that 8 hours assumes you drank all 4 pints at once.
units of alcohol is about strength % * volume (in litres)
So a metric pint (half litre) of 4% beer is 2 units.
If you begin at at fairly normal 20:00, drink 4 pints between then and 00:00, that's already 2 of the pints gone from the system, the next 2 by 02:00. Driving to work the next day at 08:00 won't be an issue.
(This is a rough estimate as it takes some time for your liver to start processing the alcohol obv.)
In the UK, the drink driving limit, roughly, for a 12 stone man, is around 4 units, so you would unlikely be over the limit if you waited an hour or so after midnight and then drove (but I wouldn't recommend risking it).


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Evening Open House
St. Margaret's School and Ocean Networks Canada
Wednesday, 25 January 2017 from 4:00 PM to 8:00 PM (PST)
Event Details
4:00pm | Early Primary Info Session (Junior Kindergarten to Grade 1)
6:30 - 8:00pm | Middle/Senior Session (Grade 5 to Grade 12)
7:30pm | Screenagers film
Find out why girls thrive in our leading early learning program and our internationally recognized Middle and Senior School program. This triple-header event will introduce girls and their families to what makes our school great, and welcome in current SMS families to mingle. Please note the schedule of events to arrive for the correct session.
For more information about our school, visit our admissions pages to find lots of resources for prospective students & parents, including testimonials. Or, feel free to contact us: 250-479-7171 or email our Admissions Officer, Gail Bateman.
When & Where
St Margaret's School
1080 Lucas Avenue
Wednesday, 25 January 2017 from 4:00 PM to 8:00 PM (PST)
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St. Margaret's School and Ocean Networks Canada
Founded in 1908, St. Margaret's School (SMS) is an all-girl, independent day and boarding school located in the City of Victoria on the scenic west coast of British Columbia, Canada. Tucked away on 22-acres of park-like land in the Lakehill area bordering on Blenkinsop Lake and a network of trails, it is hard to imagine a more perfect environment in which to learn and grow. SMS is a community that cares deeply about girls; we have been dedicated to their education, development and well-being for over a century. Together, we help girls become powerful learners with the knowledge, attitudes and courage to thrive – in their studies and careers, and in life.
Established in 2007 as a major initiative of the University of Victoria, Ocean Networks Canada operates world-leading ocean observatories for the advancement of science and the benefit of Canada. The observatories collect data on physical, chemical, biological, and geological aspects of the ocean over long time periods, supporting research on complex Earth processes in ways not previously possible.