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Elizabeth Wanamaker Peratrovich,
A Tlingit Native American, successfully inspired the Alaska Senate to pass the state's Anti-Discrimination Act in 1945, which banned blatant discrimination such as "no natives allowed" signs posted in storefronts.
Elizabeth was born on July 4, 1911 in Petersburg, Alaska. She was an orphan and was adopted as a toddler by Andrew and Mary Wanamaker, a Tlingit couple, and named Elizabeth Wanamaker. Andrew was a Presbyterian minister. Elizabeth was raised in Petersburg and Ketchikan, Alaska. She attended Sheldon Jackson College in Sitka, and the Western College of Education in Bellingham, Washington back then.
On December 15, 1931, Elizabeth married Roy Peratrovich a politician.They lived in Klawock, where Roy was elected to four terms as mayor. They had three children daughter Loretta, and sons Roy, Jr. and Frank.
In 1941, while living in Juneau, the Peratroviches found more discrimination, having difficulty finding housing and seeing signs banning Native entry to public facilities. They petitioned the territorial governor, Ernest Gruening, to ban the "No Natives Allowed" signs then common at public accommodations in that city and elsewhere. The Anti-Discrimination Act was defeated by the territorial legislature in 1943. As leaders of the Alaska Native Brotherhood and the Alaska Native Sisterhood, the Peratroviches lobbied the territory's legislators and represented their organizations in their testimony.
Elizabeth Peratrovich was the last to testify before the territorial Senate voted on the bill in 1945, and her impassioned testimony was considered decisive.
I would not have expected that I, who am barely out of savagery, would have to remind gentlemen with five thousand years of recorded civilization behind them, of our Bill of Rights.
She was responding to earlier comments by territorial senator Allen Shattuck of Juneau. He had earlier asked, "Who are these people, barely out of savagery, who want to associate with us whites, with 5,000 years of recorded civilization behind us?"The Senate voted 11-5 for House Resolution 14, providing "…full and equal accommodations, facilities, and privileges to all citizens in places of public accommodations within the jurisdiction of the Territory of Alaska; to provide penalties for violation."The bill was signed into law by Governor Gruening, nearly 20 years before the US Congress passed the Civil Rights Act of 1964. Acts of the territorial legislature required final approval from the U.S. Congress, which affirmed it.
Fran Ulmer, who represented Juneau in the Alaska House of Representatives (and who later became lieutenant governor of Alaska, in 1992 said the following about Peratrovich's testimony:
"She talked about herself, her friends, her children, and the cruel treatment that consigned Alaska Natives to a second-class existence. She described to the Senate what it means to be unable to buy a house in a decent neighborhood because Natives aren't allowed to live there. She described how children feel when they are refused entrance into movie theaters, or see signs in shop windows that read "No dogs or Natives allowed"
For what ever reasons after winning this enourmous victory, the family relocated to Antigonia, Nova Scotia, Canada, where Roy pursued an economics degree at St. Francis Xavier University. From there they moved to Denver, Colorado, where Roy studied at the University of Denver. In the 1950s, the Peratroviches moved to Oklahoma, and then back to Alaska.
Elizabeth Peratrovich died of cancer on December 1, 1958. She is buried at Evergreen Cemetery, Juneau, Alaska alongside her husband Roy.
Son Roy Peratrovich, Jr., became a noted civil engineer in Alaska. He designed the Brotherhood Bridge in Juneau, which carries the Glacier Highway over the Mendenhall River. In 1979, he co-founded the firm Peratrovich Nottingham & Drage, now known as PND Engineers. After retiring from the engineering profession, he now works as an artist based on Bainbridge Island, Washington.


text:
With Google Chrome now showing warning messages in the browser on insecure sites, we thought it was time to quickly explain what HTTPS is and why it's important.
Email marketing isn't showing any signs of going away. For large and small businesses alike it remains one of the most valuable tools at a marketer's disposal.
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subset: commoncrawl


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IPC 2016 is planned to start on 26 Sep and end on 30 Sep 2016.
The venue of the Conference will be Hyatt Regency which is one of the great place for such an important event.
IPC 2016, 11th International Pipeline Conference & Exhibition is one of the essential event on Engineering, Pipeline Safety, Pipelines, Pipeline Operations and Pipeline Technology spots.
11th International Pipeline Conference & Exhibition is a biennial Conference.
The association of the 11th International Pipeline Conference & Exhibition is American Society of Mechanical Engineers.
Hyatt Regency
Address : 636 Centre Street Southwest, Calgary, AB T2G, Canada
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Calgary, AB, Canada
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24 - 25 April 2019
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03 - 04 February 2018
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24 - 25 March 2018
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Quick Facts
Type 2 Diabetes
Type 2 diabetes is a chronic disease in which your body is unable to maintain a normal blood sugar (glucose) level.
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About Dr. Srinadh Rao
Dr. Srinadh Rao, MD is a Doctor primarily located in Buffalo, NY, with other offices in Hollister, CA and Chandler, AZ (and 2 other locations). He has 12 years of experience. His specialties include Pediatric Cardiology and Pediatrics. Dr. Rao is affiliated with Hazel Hawkins Memorial Hospital, Natividad Medical Center and Providence Alaska Medical Center. He speaks English.
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Recent improvements in South Korean households\' balance sheets mainly came as consumer spending remained subdued amid a prolonged economic slowdown, a central bank report showed Monday. After the 2008 global financial crisis until 2011, households\' balance sheets had worsened due to the economic slowdown, according to the report by the Bank of Korea (BOK). But since then, it has improved mainly driven by weak consumer spending and repayment of debts, not by income growth, it added. The average ratio of households\' balance sheets to their gross income reached 25.9 percent in 2012, up from 23.3 percent from the previous year, the report showed. The ratio, which came in at 24.1 percent in 2008, declined to 22.7 percent in 2010. The Korean economy grew 1.1 percent on-quarter in the second quarter, the fastest growth in more than two years, aided by an increase in government spending. But consumer spending remained lackluster, growing a mere 0.6 percent on-quarter in the second quarter. Households\' debt growth has somewhat slowed amid the economic downturn, but households\' high indebtedness is feared to crimp consumer spending, curbing the economic growth. Korea\'s total household credit stood at 961.6 trillion won (US$864.4 billion) as of end-March.
GMT 10:30 2017 Tuesday ,21 NovemberUS state gives key approval for Keystone pipeline
GMT 18:10 2017 Monday ,20 NovemberPhilippines' Duterte offers telecoms role to new ally China
GMT 18:03 2017 Monday ,20 NovemberBrexit and the City: taking London's financial pulse
GMT 15:27 2017 Sunday ,19 NovemberEU slashes Turkey's pre-accession funds by $124m
GMT 15:05 2017 Sunday ,19 November"No fireworks" at NAFTA talks, but few signs of progress
GMT 23:11 2017 Friday ,17 NovemberIMF sees stronger growth in Myanmar, but Rohingya crisis may hurt investment
GMT 22:59 2017 Friday ,17 NovemberBitcoin at all-time high near $8,000
GMT 22:38 2017 Friday ,17 NovemberBitcoin bubble warning, but blockchain takes off


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Blitzkrieg 101 revisited. How a mix of old tactics was turned into a new military doctrine, blending manoeuvre warfare and combined arms.
30th of September 2015 in Syria: And so it begins…
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X-FILES: Encounters on the Battlefield
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Nuclear close calls: How the Cold War brought the world to the edge of destruction and how we seem to follow the same path…


text:
KAMLOOPS — Oct 8-14 is Homelessness Action Week, a time when communities across B.C. work to bring awareness to the issue of homelessness, and what services are available.
"It's a time of year to bring awareness to homelessness and the topics associated with it, poverty, mental health, addictions and recovery, and then the services that are available to help out with those issues as well," Natalie Serl, project manager of housing and homelessness for the City of Kamloops, said.
Thirty-seven service providers will attend Project Connect at Spirit Square Wednesday, where they will be able to connect to those who need their supports most.
"It's a way to connect with people in a very casual and informal way that isn't intimidating, as it can be sometimes when you're trying to find an opportunity for improvement for your life," Serl said. "So, it isn't just for our homeless population, it's an all community support event that we offer."
The Kamloops division of the Canadian Mental Health Association works closely with the city's homeless population, and is one of the agencies participating in Project Connect.
"We work in this every single day as the operators of Emerald Centre," said Executive Director Christa Mullaly, "and I think that by really responding to and encouraging our clients and the residents that are staying with us to connect into services to be able to be better supported in community is ongoing work that we do everyday."
Mullaly says Kamloops is in great need of homes for the homeless, but she's optimistic they are on the way.
"I think a lot of the excellent groundwork has been laid in Kamloops for us to receive some of the provincial funding that's coming down around housing, around other supports for the homeless population," Mullaly said, "but it's kind of that hurry up and wait syndrome as well. We really need to get some units into our community and I am absolutely confident that we've got some stuff coming down the pipe, which is excellent."
That would be in addition to another housing initiative already underway for First Nations, Inuit, and Metis youth who have aged out of care.
"About 60 per cent of homeless people had associations with child welfare services at some point in their life, and I think in Kamloops the statistic is actually 72 per cent," said Natika Bock, Indigenous Youth Housing Manager with Lii Michif Otipemisiwak Family and Community Service. "So, we're higher than the national average. This housing project will help youth aging out of care so that they're supported in housing, and have a continuum of supportive up until they're ready to live on their own."
Many agencies have chosen to extend their own Homelessness Action Week activities into next week.
The annual homeless count that is normally done over Homelessness Action Week will take place next spring as part of a coordinated count with other communities across Canada.
Kamloops MLA slams referendum process
KAMLOOPS — Earlier this week the NDP launched a public engagement survey called 'How we Vote'. The...
Peterson Creek Multi-Use Path construction going as planned
KAMLOOPS — According to city staffers, work is progressing as planned on a multi-use pathway which...
City of Kamloops announces 'enhancements' to Stuart Wood shelter
KAMLOOPS — The City of Kamloops has announced a number of 'enhancements' to the temporary emergency...
World Mental Health Day sheds light on mental illness
Stone has 'a tough row to hoe' in leadership bid says retired TRU prof
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Teen fatally shot during brawl outside Northeast Side restaurant
Man behind the tiny defiant Christmas tree at the Alamo speaks...
Despite outpouring of support, Olmos Pharmacy officially closed
'Sexy,' new bar opens in downtown San Antonio
These areas are hit hardest by theft in San Antonio during the...
Conjunto legend Ramón Ayala is coming to S.A. next month
Aaron Hernandez's Mansion Finally Sells for a Deep Discount
AP source: Authorities believe border agent may have fallen
Deputies investigating possible homicide after man found dead...
Police release names of men arrested on sex trafficking...
Monthly Archive for June, 2007
René A. Guzman: No, Luke — I am your Father's Day present
Nothing says, "Dad, I'm a geek and I love you" like a "Star Wars" Father's Day card with Luke Skywalker and Darth Vader figures. (Pic from link.) Then again, maybe it really says, "Dad, I hate it when …
René A. Guzman: What you need to know about upcoming Magic: The Gathering Tenth Edition
I haven't played Magic: The Gathering in quite some time, but it'll always have a place in my heart, if only for the fun I had throwing down my plains against my nephew's swamps. (And if you have no …
Sean M. Wood: Anthony Daniels talks Star Wars
(Fort Worth Star-Telegram/Khampha Bouaphanh) Geeks around North Texas will be flocking to this exhibit. The Fort Worth Star-Telegram has a fun article about this exhibit I told you about last week. …
René A. Guzman: 'Fallen Son: The Death of Captain America — Spider-Man' just might be worth the dough
Look, I'm not too crazy about Cap's death anymore than you are. But you have to hand it to Marvel when it at least pairs two top-shelf talents for a book about the hero's death. Case in point: Jeph …
Chris Quinn: In defense of lightboarding, and a pinch of hillbilly pig farmers
I am falling in love with Alien Pig Farm the more and more I think about this insane series. Issue two hits stands today. But be sure to go check out this really cool interview with that series' book …
René A. Guzman: 'Thundercats' to get the movie treatment
Movie, movie, movie — moviecats, ho! (Screen grab from Thundercatslair.org.) Here thunderkitty-kitty. There's a report that Warner Bros. has optioned a script for that cool-cat cartoon series …
Sean M. Wood: Remember the Mighty Heroes?
We were just talking about this silliness the other day. Aside from the opening, YouTube also has a few episodes. I'm instantly thrust back to the family den, where I watched after getting home from …
Sean M. Wood: Captain Canuck to the rescue
(Comely Comix) Our Cap may be dead but Canada's Captain Canuck is alive and kicking. Guess what? The Canadians could give two broken hockey sticks for Alpha Flight. When it comes to Canadian heroes, …
Chris Quinn: Transform your phone for gaming
As the July 4th opening of the highly anticipated Transformers movie nears, Glu Mobile Inc. is offering this, the first Transformers movie game for your phone. The game features game play as Optimus …
René A. Guzman: And now for something completely funny — a 'Star Wars'/'Holy Grail' mashup
Nothing like a Darth Vader/Monty Python mashup to, uh, get the blood flowing. (Thanks to Dean L for the vid.) …


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Global Thermal Transfer Label Market: Evolving Industry Trends and key Insights by 2025
The market for thermal transfer label is catering to diverse application sectors, ranging from healthcare and transportation to retail and electronics, and feeding off the prosperity of each of them. Consequently, the demand in the global thermal transfer label market is projected to expand at a substantial CAGR of 5.5% during the forecast period of 2017 to 2022. The future of the thermal transfer label market is also dependent on innovation, as there are vast possibilities of its application for simple to complex tracking of products, individuals, and payment transfers.
The thermal transfer labels are adoptable to irregular and curved surfaces, offer resilience against wear and tear, and vastly improve the efficiency of tracking in busy environments such as airports, hospitals, and retail shops. As far as revenue is concerned, the global thermal transfer label market has been estimated to be worth US$3,003.3 mn by 2022, up from its evaluated valuation of US$2,296.6 mn in 2017.
Obtain Report Details @
Paper Thermal Transfer Labels Producing Maximum Demand
Based on material, the global thermal transfer label market has been segmented into paper, polyester, polypropylene (PP), and polyethylene (PE). In 2017, paper segment accounted for 36.7% of the total demand in the thermal transfer label market across the world, generating a revenue of US$843.7 mn. During the forecast period of 2017 to 2022, the demand for paper thermal transfer label is anticipated to increase at a CAGR of 7.5%, which is much higher than the other three segments. Paper labels can withstand environmental conditions such as heat and sunlight, offer high quality printing and unlimited flexibility, and moderate durability. These labels are available in a variety of sizes to meet the requirement. By the end of 2022, the paper segment of thermal transfer label market has been estimated to be worth US$1,209.3 mn, which will reflect 40.3% of the overall demand. This segment is growing at 73.1 mn annually over the course of the forecast period.
On the basis of printer type, the global market for thermal transfer label has been bifurcated into desktop, industrial, and mobile, whereas application-wise, the market has been categorized into healthcare, tracking, logistics, and transportation, industrial goods and products, retail, semiconductor and electronics, and others.
Download TOC @
APEJ Projected for Best Growth Rate among All Regions
Geographically, apart from a dedicated chapter on the country of Japan, the report takes stock of the potential of the thermal transfer label market in the regions of North America, Europe, Latin America, Asia Pacific except Japan (APEJ), and the Middle East and Africa (MEA). During the forecast of the forecast period of 2017 to 2022, the APEJ region is projected for the best CAGR among all regions, i.e. 6.9%. This region is estimated to produce a demand for thermal transfer label worth of US$293.2 mn between 2017 and 2022. North America is another highly profitable region, though the progress rate is lot slower than that of APEJ. Expanding the demand at 4.3% during the said forecast period, the North America thermal transfer label market is evaluated to be worth US$616.9 mn by 2022, significantly up from its valuation of US$499.4 mn in 2017.
The Europe thermal transfer label market is expanding at a CAGR of 4.9% and promises to present a demand worth of US$754.3 mn, whereas the revenue from MEA thermal transfer label market is anticipated to increase at a CAGR of 4.9% over 2017-2022, to reach US$ 176.7 mn by 2022.
Honeywell International Inc., Henkel AG & Co. KGaA, CCL Industries Inc., 3M Company, Constantia Flexibles Group GmbH, LINTEC Corporation, Inland Label and Marketing Services LLC, WS Packaging Group, Inc., Multi-Color Corporation, and Coveris Holdings S.A. are some of the key players venturing in the global thermal transfer label market.
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Jobs in Hertfordshire (GB)
To get your perfect job in Hertfordshire (GB) sent to you the day it's posted, sign up for our job alert service.
Found 20 jobs in this campaign
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Specialist Travel Consultant
Have you been Travelling and do not want the memories to fade??? Did you visit Australia, Asia, Africa or America? Do you have sales experience???...
BUSINESS TRAVEL TEMPS REQUIRED Are you an experienced Business Travel Consultant available to immediately start work? If you have up to date fares ...
Luxury Travel Consultant
Our client is a luxury travel company that offer bespoke holiday packages across the globe now seeking an experienced Luxury Travel Consultant
Move from Retail Travel to Luxury (Mon-Fri)
This is a perfect position for a travel consultant looking to move into a Luxury, Monday to Friday, 9am-5.30pm travel role. Award winning and exclu...
Travel Consultant
Want to fly high in your next career move? Sales driven, dynamic and fun loving Travel Consultant required!!!! - working for one of the UK's leadin...
Personal Travel Executives
Personal Travel Executives - UK's Luxury Premier Tour Operator Welwyn Garden City £20,000+ Bonuses and Benefits - OTE £30,000 uncapped My client, t...
Personal Luxury Travel Consultant (Mon-Fri)
Personal Luxury Travel Consultant - Our client has a strong reputation for excellence and has been offering high end travel products to its establi...
Boutique Travel Store - Luxury Travel Consultant
Luxury Travel Consultant role. Our client is a Multi Award Winning, Boutique Travel Store based in an affluent part of North London. Established fo...
Luxury Travel Consultant – Boutique Travel Store
Luxury Travel Consultant role. Our client is a Multi Award Winning, Boutique Travel Store based in an affluent part of North London. Established fo...
Personal Travel Expert - John Lewis Welwyn Garden City
We Live and Love Travel.... Do you? There's a very simple reason why Kuoni consistently tops the awards, it's thanks to our outstanding teams who g...
Managing Director
Managing Director - A fantastic opportunity to join a well-established, mid-size travel company based in Hertfordshire, responsible for creating an...
Motorcycle Travel Consultant - India
Relocate to India? Our client, a Motorcycle Touring Specialist Tour Operator are looking for a native English speaker to join them at their office ...
Travel Consultant
Travel consultant - Required for this lovely family run travel company that specialise on upmarket trips to the USA. They are looking for an experi...
Travel Sales Team Leader
Calling all Senior Travel Consultants, Travel Sales Team Leaders, Assistant or Branch Managers! Based close to the Bedfordshire/ Hertfordshire bord...
Worldwide Travel Sales Consultant
Travel Consultants, are you a strong seller who enjoys tailor-making packages to Worldwide destinations? Are you looking for a great new role with ...
S.E.Asia Travel Specialist
Have you been Travelling and do not want the memories to fade??? Did you Travel around South East Asia and want to pass your experiences on to othe...
Luxury Travel Consultants - VIP
We are seeking experienced and dynamic Luxury Travel Consultants to join an elite and award winning boutique tour operator due to remarkable growth.
Luxury Travel Planners
Our client is a dynamic, award winning and forward thinking tour operator now seeking Luxury Travel Planners to join the team
Stevenage- Personal Holiday Advisor - 22.5Hrs
Join us as a Personal Holiday Advisor, and you will help our customers to once-in-a-lifetime experiences
Stevenage- Personal Holiday Advisor
Join us as a Personal Holiday Advisor, and you will help our customers to once-in-a-lifetime experiences


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LegrandView All Tags
Legrand's Wireless Lighting System Seamlessly Blends Tech and Design
Do your renters need to control their lighting with a wireless remote or smartphone? No, but they probably don't need a tanning bed or misting station either. That doesn't mean they don't want them.National 15 October 2013 17:10
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- Download the
EBook Queen Victoria
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Official War Rule Book
I Love My Love With An A
To play this game it is best for the players to arrange thems...
"what's My Thought Like?"
The players sit in a circle and one of them asks the others: ...
St Valentine's Post Office
The players sit in a circle around the room except one who is...
Hopping Game
Squares are chalked on the ground, thus:-- [Illustration: ...
_9 to 25 players._ _House party._ An uneven number of...
Lawn Hockey
This game is played on a field a little smaller than a footba...
Paper Mats
Take a square piece of thin paper (Fig. 1), white or color...
Cross Tag
This is the ordinary "Tag," save that if, while the "It" is c...
Poem Race
School, Church, and Home Games
SCHOOLROOM GAMES For Intermediate Pupils
The pupils having learned some poem may use it in a game in the
following way:
The pupils of each aisle constitute a team. At the signal to go the
last pupil in each aisle stands up and recites the first line of the
poem, returns to his seat and taps the one next in front of him, who
stands up and repeats the second line of the poem, sits down and taps
off the third pupil, who repeats the third line, and so the game
continues. If the poem has not been completed after the one in the
front seat has said his line, he taps the one next behind him, and that
one is supposed to give the next line and so on back. The aisle first
completing a poem wins the race.
If the poem be a very small one, words of the poem instead of lines may
be used. If it be a long one, verses instead of lines may be used.
Last Man
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For The Younger Children
An Indoor Sports Fair


text:
Research Topics
Genomes and Genes
Gene Symbol: Socs1
Description: suppressor of cytokine signaling 1
Alias: Cish1, Socs-1, suppressor of cytokine signaling 1, cytokine inducible SH2-containing protein 1
Species: rat
Top Publications
Scientific Experts
Detail Information
- Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signalingZ Wang
Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Biochem Biophys Res Commun 277:20-6. 2000....
- Evidence for translational repression of the SOCS-1 major open reading frame by an upstream open reading frameG Schluter
Institute of Human Genetics, University of Gottingen, Heinrich Düker Weg 12, Gottingen, 37073, Germany
Biochem Biophys Res Commun 268:255-61. 2000....
- MiR-19a targets suppressor of cytokine signaling 1 to modulate the progression of neuropathic painConghui Wang
Department of Anesthesiology, The First Hospital of Xiangyang City Xiangyang 441000, Hubei Province, China
Int J Clin Exp Pathol 8:10901-7. 2015..We aimed to investigate whether miR-19a is associated with neuropathic pain and elucidate the underlying regulatory mechanism...
- Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signalingEmilie Bourdonnay
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School and Department of Environmental Health Sciences, School of Public Health University of Michigan, Ann Arbor, MI 48109
J Exp Med 212:729-42. 2015..Here we report that alveolar macrophages can secrete SOCS1 and -3 in exosomes and microparticles, respectively, for uptake by alveolar epithelial cells and subsequent ..
- Suppression of microRNA-155 attenuates neuropathic pain by regulating SOCS1 signalling pathwayYi Tan
Department of Anesthesiology, Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, People s Republic of China
Neurochem Res 40:550-60. 2015..that miR-155 directly bound with the 3'-untranslated region of the suppressor of cytokine signalling 1 (SOCS1)...
- Suppressor of cytokine signaling 1 (SOCS1) mitigates anterior uveitis and confers protection against ocular HSV-1 infectionCheng Rong Yu
Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Building 10, Room 10N109A, 10 Center Drive, Bethesda, MD, 20892 1857, USA
Inflammation 38:555-65. 2015..Suppressors of cytokine signaling (SOCS) regulate intensity/duration of inflammatory responses. We have used SOCS1-deficient mice and retina-specific SOCS1 transgenic rats to investigate roles of SOCS1 in ocular herpes simplex ..
- Elevated suppressor of cytokine signaling-1 (SOCS-1): a mechanism for dysregulated osteoclastogenesis in HIV transgenic ratsMark K Lafferty
Division of Basic Science and Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA
Pathog Dis 71:81-9. 2014..Understanding the molecular mechanisms of HIV-associated BMD changes has the potential to detect and treat bone metabolism disturbances early and improve the quality of life in patients. ..
- Effects of ischemic preconditioning on myocardium Caspase-3, SOCS-1, SOCS-3, TNF-α and IL-6 mRNA expression levels in myocardium IR ratsJiangwei Ma
Department of Cardiology, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing, 210008, China
Mol Biol Rep 40:5741-8. 2013..01) compared to IR model group. We conclude that IP is effective in the therapy of heart disease. These findings may have implications for the clinical development of preconditioning-based therapies for ischemic heart disease...
- Interferon-γ biphasically regulates angiotensinogen expression via a JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cellsRyousuke Satou
Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
FASEB J 26:1821-30. 2012..RPTCs were incubated with or without IFN-γ up to 48 h. AGT expression, STAT1 and STAT3 activities, and SOCS1 expression were evaluated...
- Inhibition of microRNA let-7i depresses maturation and functional state of dendritic cells in response to lipopolysaccharide stimulation via targeting suppressor of cytokine signaling 1Maomao Zhang
Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin Medical University, Harbin, Heilongjiang Province 150081, China
J Immunol 187:1674-83. 2011..Furthermore, Tregs with upregulated IL-10 underscored the tolerogenic effect of CD86(-) DCs. Suppressor of cytokine signaling 1 (SOCS1), a crucial mediator of DC maturation, was confirmed as a let-7i target gene by luciferase ..
- Suppressor of cytokine signaling 1 inhibits apoptosis of islet grafts through caspase 3 and apoptosis-inducing factor pathways in ratsG J Suo
Department of Surgery, Shanghai East Hospital, Tongji University, PR China
Transplant Proc 42:2658-61. 2010..Recently, we observed that overexpression of suppressor of cytokine signaling 1 (SOCS1) in islet grafts achieved an antiapoptotic effect, prolonging graft survival in a rat ..
- Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigensSheela Ramanathan
Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Canada
J Immunol 185:357-66. 2010..In this study, we examined whether CD8 T cells that accumulate in suppressor of cytokine signaling 1 (SOCS1)-deficient mice because of increased IL-15 signaling in vivo would respond to an autoantigen ..
- JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathwayNa Lv
Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561 756, Republic of Korea
Exp Cell Res 315:2064-71. 2009....
- Overexpression of suppressor of cytokine signaling 1 in islet grafts results in anti-apoptotic effects and prolongs graft survivalJie Qin
Department of Anatomy, Histology and Embryology, Shanghai Medical College, Fudan University, 130 Dong an Road, Shanghai 200032, China
Life Sci 84:810-6. 2009..The aim of this study was to investigate whether overexpression of suppressor of cytokine signaling 1 (SOCS1) in islet grafts could achieve an anti-apoptotic effect and prolong graft survival.
- Increased expression of suppressor of cytokine signaling-1 (SOCS-1): A mechanism for dysregulated T helper-1 responses in HIV-1 diseaseAnjana Yadav
Institute of Human Virology of the University of Maryland School of Medicine, Baltimore, MD 21201, USA
Virology 385:126-33. 2009..These results suggest a link between high levels of SOCS-1, defects in innate immunity and adaptive Th1 responses that may be reflected in the loss of Th1 immune competence observed with AIDS patients...
- HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitusMichael J Carper
Washington University School of Medicine, Department of Internal Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Southwest Tower, Room 846A, Campus Box 8127, 660 South Euclid Drive, St Louis, MO 63110, USA
Am J Physiol Endocrinol Metab 294:E558-67. 2008..Our findings therefore indicate that induction of the SOCS-1 signaling cascade by PIs could be an important contributing factor in the development of metabolic dysregulation associated with long-term exposures to HIV-PIs...
- Sequence analysis of the conserved protamine gene cluster shows that it contains a fourth expressed geneG Schluter
Institut für Humangenetik der Universität, Gottingen, Germany
Mol Reprod Dev 43:1-6. 1996..5 kb. Finally, we demonstrate a high density of Alu elements, both full and fragmented copies, in the human PGC and discuss their localization with respect to evolutionary and functional aspects...
- Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanismsKohjiro Ueki
Research Division, Joslin Diabetes Center, and Departmentof Medicine, Harvard Medical School, Boston, MA 02215, USA
Mol Cell Biol 24:5434-46. 2004..These data indicate that SOCS-1 and SOCS-3 act as negative regulators in insulin signaling and serve as one of the missing links between insulin resistance and cytokine signaling...
- SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptorSamir Ali
Department of Medicine, Division of Hematology and Molecular Oncology Group, Royal Victoria Hospital, McGill University, Montreal, Quebec H3A 1A1, Canada
J Biol Chem 278:52021-31. 2003..Together our results provide a novel function for SHP-2 as a positive regulator of cytokine receptor signaling by regulating ubiquitination/degradation pathways...
- 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in gliaEun Jung Park
Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea 442 721
J Biol Chem 278:14747-52. 2003..Our data suggest that 15d-PGJ(2) and rosiglitazone suppress the initiation of JAK-STAT inflammatory signaling independently of PPAR-gamma, thus attenuating brain inflammation...
- Activation of signal transducer and activator transcription 3 and expression of suppressor of cytokine signal 1 during liver regeneration in ratsShigeru Sakuda
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
J Hepatol 36:378-84. 2002..The aims of this study were to identify STAT3-activated cells and to clarify the expression of suppressor of cytokine signal (SOCS), a negative feedback molecule of STAT3, after PH...
- Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistanceR A Mooney
Department of Pathology, University of Rochester School of Medicine, Rochester, New York 14642, USA
J Biol Chem 276:25889-93. 2001..These results suggest that SOCS proteins may be inhibitors of IR signaling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes...
- Effects of SOCS 1/3 gene silencing on the expression of C/EBPα and PPARγ during differentiation and maturation of rat preadipocytesRui dan Zheng
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Pediatr Res 73:263-7. 2013..Subjects with insulin resistance are often obese and have increased expressions of SOCS-1 and SOCS-3. We speculated that SOCS-1 and SOCS-3 may be involved in abnormal deposition of adipose tissues during insulin resistance...
- SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathwayAntonio Cittadini
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
Cardiovasc Res 96:381-90. 2012..To this aim, we investigated the effects of SOCS1 overexpression obtained by in vivo adeno-associated gene transfer using an aortopulmonary cross-clamping technique ..
- Functional cross-modulation between SOCS proteins can stimulate cytokine signalingJulie Piessevaux
Flanders Interuniversity Institute for Biotechnology, Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Ghent University, B 9000 Ghent, Belgium
J Biol Chem 281:32953-66. 2006..Our findings point to a unique regulatory role for SOCS2, SOCS6, and SOCS7 within the SOCS family and provide an explanation for the unexpected phenotypes observed in SOCS2 and SOCS6 transgenic mice...
- Differential expression of suppressors of cytokine signalling genes in response to nutrition and growth hormone in the septic ratT S Johnson
Division of Clinical Sciences, Sheffield University, Northern General Hospital NHS Trust, Herries Road, Sheffield S5 7AU, UK
J Endocrinol 169:409-15. 2001..Here, we have investigated the impact of nutrition and GH treatment on GH receptor, SOCS1, SOCS-2, SOCS-3 and cytokine-inducible SH2-containing protein (CIS) hepatic mRNA expression in a rat model of ..
- Signaling through the JAK/STAT pathway, recent advances and future challengesT Kisseleva
Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Gene 285:1-24. 2002..Similarly, the solution of the crystal structure of two STATs has and will continue to facilitate our understanding of how STATs function. This review will highlight these exciting developments in JAK/STAT signaling...
- Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylationLy Q Hong-Brown
Department of Cellular and Molecular Physiology, Hershey, Pennsylvania 17033, USA
Am J Physiol Endocrinol Metab 285:E63-72. 2003..In conclusion, sepsis produces GH resistance in both muscle and liver, with the locus of this impairment in muscle differing from that in liver and being independent of a defect in STAT5 phosphorylation...
- Suppressor of cytokine signalling gene expression is elevated in breast carcinomaM Raccurt
CNRS UMR 5123, Bât Raphaël Dubois, Universite Claude Bernard Lyon 1, 43 Blvd 11 Novembre 1918, F69622 Villeurbanne cedex, France
Br J Cancer 89:524-32. 2003....
- The influence of down-regulation of suppressor of cellular signaling proteins by RNAi on glucose transport of intrauterine growth retardation ratsLihong Liao
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Pediatr Res 69:497-503. 2011..Down-regulation of SOCS-1 and SOCS-3 ameliorates the capacity of glucose transport and provides a potential gene therapy approach to managing metabolic syndrome...
- Suppressors of cytokine signaling abrogate diabetic nephropathyGuadalupe Ortiz-Muñoz
Renal and Vascular Research Laboratory, Fundacion Jimenez Diaz, Autonoma University, Madrid, Spain
J Am Soc Nephrol 21:763-72. 2010..In a rat model, inducing diabetes resulted in JAK/STAT activation and increased expression of SOCS1 and SOCS3...
- [Polymorphism and structural analysis of suppressor of cytokine signaling-1 of rat]Jia Xu
Department of General Internal Medicine, First Affiliated Hospital of Sun Yat sen University, Guangzhou 510080, Guangdong, China
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:259-62. 2010..To identify the suppressor of cytokine signaling-1 (SOCS-1) of rat from the amplified gene with the help of bioinformatics to predict the deduced protein's structure and function in order to lay the foundation for further theoretical study...
- Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancerMakoto Suzuki
Hamon Center for Therapeutic Oncology Research University of Texas Southwestern Medical Center, Dallas TX, USA
Cancer Lett 242:222-30. 2006..were Reprimo, 54%; TMS1, 47%; DcR1, 45%; RRAD, 37%; DcR2, 37%; CRBP1, 34%; HPP1, 32%; RIZ1, 31%; DRM/Gremlin, 21%; SOCS1, 20%; DR4, 5%; DR5, 1%...
- Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouseKohjiro Ueki
Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 101:10422-7. 2004..Thus, SOCS proteins play an important role in pathogenesis of the metabolic syndrome by concordantly modulating insulin signaling and cytokine signaling...
- Differential hypermethylation of SOCS genes in ovarian and breast carcinomasKate D Sutherland
The Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
Oncogene 23:7726-33. 2004..We have investigated whether silencing or inactivation of SOCS genes occurs in ovarian and breast carcinomas. The SOCS1 and SOCS2 CpG islands were found to be hypermethylated in 23 and 14% of primary ovarian cancers, respectively, ..
- [Expression of suppressor of cytokine signaling in retina of experimental autoimmune uveoretinitis]Hong Wang
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Zhonghua Yan Ke Za Zhi 44:876-82. 2008..To investigate the expression and significance of suppressor of cytokine signaling (SOCS) mRNA and protein in retina of rats with experimental autoimmune uveoretinitis (EAU)...
- Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinomaMartin G Friedrich
Department of Urology, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
Eur J Cancer 41:2769-78. 2005..We identified one gene (TIMP-3) where methylation was associated with a more favourable outcome. Our data strongly support the usefulness of gene methylation as a prognostic marker in patients with non-muscle invasive bladder cancer...
- Donor bone-marrow suppressor of cytokine signaling-1-silenced dendritic cells prolong rat intestinal allograft survivalC Zhu
Department of General Surgery, Changzhou No 2 People s Hospital, Affiliated to Nanjing Medical University, Changzhou, Jiangsu, China
Transplant Proc 40:3707-10. 2008..The difference between untreated DCs group and the control group was not significant. In summary, SOCS-1 silenced DCs induced allogeneic T-cell hyporesponsiveness in vitro, promoting allograft survival in rat intestinal transplantation...
- [The study on the role of SOCS1 and SOCS3 in the livers of endotoxin tolerance rats]Ming Qin Lu
Department of Infection Disease, First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China
Zhonghua Yi Xue Za Zhi 88:2652-7. 2008To explore the mechanism of endotoxin tolerance(ETT) through observing the gene expression of SOCS1 and SOCS3 in the livers of ETT rats.
- Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in ratsTetyana V Bagnyukova
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
Cell Cycle 7:3202-10. 2008..activation of the STAT3 occurred only in fully developed HCC and was associated with downregulation of the Socs1 gene...
- Unique expression of suppressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivoYu Liu
Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
J Immunol 180:6270-8. 2008..detectable SOCS proteins but those infiltrating inflamed glomeruli were rapidly polarized to express either SOCS1 (27 +/- 6%) or SOCS3 (54 +/- 12%) but rarely both (10 +/- 3%)...
- Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumorsAndrea Worschech
Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Massey Cancer Center, Richmond, VA 23298, USA
Cancer Res 68:2436-46. 2008..These data provide a road map for the identification of novel biomarkers of immune responsiveness in clinical trials...
- Hormonal regulation of suppressors of cytokine signaling (SOCS) messenger ribonucleic acid in the arcuate nucleus during late pregnancyFrederik J Steyn
Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, University of Otago School of Medical Sciences, PO Box 913, Dunedin 9054, New Zealand
Endocrinology 149:3206-14. 2008....
- Alteration in erythropoietin-induced cardioprotective signaling by postinfarct ventricular remodelingTakayuki Miki
Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Chuo Ku, Japan
J Pharmacol Exp Ther 317:68-75. 2006..However, in the remodeled myocardium, lack of PI3K/Akt activation by the EPO receptor seems to be compensated by a mechanism upstream of the guanylyl cyclase-mitoK(ATP) channel pathway to achieve EPO-induced protection...
- [DNA methylation on urinalysis and as a prognostic marker in urothelial cancer of the bladder]M G Friedrich
Klinik und Poliklinik fur Urologie, Universitat Hamburg, Universitatsklinikum Hamburg Eppendorf, Hamburg
Urologe A 46:761-8. 2007..We studied the versatility of DNA methylation for noninvasive diagnosis and as a prognostic marker for non-muscle-invasive bladder carcinoma...
- Attenuation of leptin and insulin signaling by SOCS proteinsJane K Howard
Endocrine Unit, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK
Trends Endocrinol Metab 17:365-71. 2006..evidence suggests that SOCS3 appears to be of particular importance in the development of leptin resistance, whereas the ability to diminish insulin action has been described for several SOCS proteins (SOCS1, SOCS3, SOCS6 and SOCS7).
- In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected womenA F Nicol
Immunology Service of Evandro Chagas Clinical Research Institute, IPEC, FIOCRUZ, Avenue Brazil 4365 Manguinhos, Rio de Janeiro, CEP 21045 900, Brazil
Exp Mol Pathol 81:42-7. 2006....


text: Home > Focus Shortages in public school system solved by 2013? By Ryan Chua, ABS-CBN News Posted at Sep 04 2012 09:16 PM | Updated as of Sep 05 2012 05:16 AM Share Save Facebook Twitter GPlus LinkedIn MANILA, Philippines – Senate education committee chairman Edgardo Angara is confident the shortage of classrooms, teachers, textbooks, and other facilities in public schools will be gone by 2013, given the Department of Education's (DepEd) increased budget. Speaking to reporters on Tuesday after a hearing on the DepEd's proposed 2013 budget, Angara noted that the agency's budget has increased by 60 percent in the past two years. "All the resource gaps in classrooms, teachers, and textbooks will be filled up by 2013," he said. Education Secretary Armin Luistro earlier said during a hearing at the House of Representatives that the DepEd's P293.2 billion budget includes P13 billion of hiring more than P60,000 teachers and 3,500 non-teaching personnel. Almost 18,000 new classrooms and more than 90,000 health and sanitation facilities will be built, and 31 million reading materials distributed to public schools nationwide, Luistro added. Angara said, however, that the DepEd must also focus on improving the quality of education aside from addressing the resource gaps. The senator pointed out that Filipino students need to be competitive on the global stage especially by 2015, when Southeast Asian countries will form one big community. "Nowadays we cannot just judge our performance against each other but against other nationalities," Angara said. "We are going to be one big community, and competition is no longer just national." Share Save Facebook Share on Twitter GPlus LinkedIn Read More: school deped budget education Classroom /sports/11/22/17/nu-ust-dispute-last-spot-in-uaap-boys-volleyball/video/business/11/22/17/ligo-magtataas-ng-presyo-ng-sardinas-sa-2018/news/11/22/17/motorcycle-shop-sa-caloocan-nasunog/overseas/11/22/17/putin-urges-political-solution-in-syria-in-calls-to-trump-mideast-leaders/overseas/11/22/17/60-of-us-women-sexually-harassed-poll-says


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Fancy Corner Home Sauna Room Design Using Recessed Lights In Front The Door Also Red Chairs Plus Showing Textured Stone Wall
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Furniture — This furniture, is one of the 18 designs published under the gallery: Relaxing Sauna Room Design For Enjoyable Spa Ideas. In the next page, we have the sharp luxurious home sauna design using modern wall thermometer and also cozy head rest on bench [ ... ]. While in the previous page, we have the joys of an at small home sauna plus l shape bench also modern heat machine [ ... ].
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text: Entrepreneurship How To Become A Successful Software Engineer Published 1 year ago on September 20, 2016 By The Asian Entrepreneur Authors & Contributors Share Tweet When it comes being great at what you do in life, there's no real formula. Some people have that natural talent for something, and others just love it enough to dedicate the time to get better at it. Regardless of how you ended up where you are, there is always room for improvement. I'm going to talk about some of the things that have helped me along the way become better at what I do: write kickass software. Realistically, you can substitute "Software Engineer" with your field and most things should still apply. Now, in no particular order… Don't stop believing learning Just because your schooling stops, it doesn't mean you stop learning. You should be constantly learning. New technologies come out, new ways of thinking take hold, and new problems need to be solved. You can't stagnate and keep solving new problems with old ways of thinking. Sometimes it works, and sometimes it does end up being the best way to do it. Many times you have to explore new spaces and examine the problem from a different point of view to find a truly excellent solution. Learning happens a number of different ways: Read Blogs, magazines, professional publications and journals, books, code, schematics, experiments, studies, whatever. Read as much as you reasonably can. Don't limit yourself to one or two formats either. Don't just read blogs. Grab a subscription to an ACM publication (Transactions on Software Engineering maybe), or whatever your field has for professional publications. Read actual books too. There is a lot of fiction being read these days, and with the explosion of blogs and online reading, physical non-fiction books aren't as popular.1 Find the good ones in your field, and buy actual books (or Kindle ebooks) and read those too. Conferences Go to conferences if you can. It's sometimes a big deal and can cost a good chunk of money to fly places and get hotel rooms, but it's worth it. I haven't even been to a software related conference yet, but I can already tell it's worth it judging from the tweets, slides, videos, and simply all the people that attend. I always learn things checking out slideshare and vimeo after the fact, so it makes sense you'd learn even more (and have more fun) actually attending. Professional development seminars These are designed to help make you better at your job, and improve your career. In my world, they are usually a day or two, but can be multi-week things that cost lots of money. Check if your employer can help you out, because in the end, it benefits them too. Learn from others I sort of break this into a couple main parts: Listen to criticism and feedback If somebody rips on your code, design, solution, whatever, it is in your best interest to listen to them. It doesn't mean you have to do what they say, but you at least listen to and analyze what they are saying. Their concerns might be completely legitimate, since they are looking at the problem and your solution through a different lens. They have their own view and are thinking about different things, and might see problems you didn't. Examine solutions to similar problems Let's say you decide you're going to write a new source control system. You probably already have a lot of good reasons if you are doing this, but you'd be stupid if you didn't examine how existing software solved the problem. Go read about git, mercurial and svn. See how they deal with merge conflicts, serving repositories, and keeping things fast. You can learn a lot by examining existing solutions. Teach I can't find the quote, but it's something relating to how you don't truly understand something until you can teach it to somebody else. So teach! If you love something, help other people learn about it. Convey what knowledge you have so that others can help solve problems and apply new technology to new problems. Teaching can take the form of giving talks at user groups, meetups and conferences, running formal classes at a site like codelesson, doing corporate training (like what Github offers), or even just walking a coworker through a piece of code you wrote. Whatever format you choose, get out there and teach. Love your job and work on stuff you care about These two work in tandem. If you hate tax software, don't work at Intuit. Pretty straight forward. You might say "but there's no good software companies in my area!" Move. If you don't like your job, don't rule out relocating to get a job you will enjoy. If you can't go to work and enjoy what you do, you might not have the motivation to work on your own stuff, since your day will be so depressing. Think about it: if you hated MIPS assembly programming, and would never do it at home, why would it be acceptable to go to work every day and do it there? Do what you love, and love what you do. No excuses! Be consistent I think consistency in how you carry and present yourself, online and off, is a big thing. It can encompass a bunch of things, from your dress (Steve Jobs is the ultimate in clothing consistency) to your coding and writing style. As an example, I ensure that my avatar and bio is the same everywhere. Pretty much any site I'm on, you'll be able to see my cartoonified self and that I'm (at the time of writing) a "Software engineer (EIT) in Edmonton, Alberta, Canada." I might leave the location out if there is another place to put location, but it's there somewhere. Writing style, dress, bio, attitude, and contact information are all things to keep in mind when it comes to being consistent. If you start giving out an email to be contacted at, keep using that email. If you are consistently a nice person on the net, don't randomly jump out and be a dick somewhere. Be consistent. It helps people remember who you are. Be contactable Living in a box sucks. If you want to move up in your career (this doesn't mean climbing the corporate ladder), you are going to want to communicate with people in your field. Have an email and maybe a phone number on your business card. Use Skype for web calls. Use a contact form from Wufoo if you don't want your email out in the open. But why not? Use Gmail and benefit from their spam filtering! By being contactable, you're making yourself available for teaching ("hey, how did you do this?"), job opportunities, and criticism, which as we talked about are all good things.2 Participate in the community This is Why the Lucky Stiff. He's awesome. He did so much for the ruby community that when he dropped off the internet, people stopped what they were doing to pick up where he left off, and take over maintenance of the the things he was involved in. If he just sat at home and kept his stuff to himself, he wouldn't be nearly as awesome. If you've got cool code, show it to people. If you did something cool in your field of work, show it off and teach others how you made it. Participate in forums, user groups, IRC channels, webinars, and Twitter discussions. Get out there and start talking to people, on and off the web. Go to conferences and get in on hack nights, and find people to go to lunch with. Crazy and interesting things can come out during lunch. Practice your trade (code) for fun If you're not coding at home, for fun, you're doing it wrong. Don't give me crap about I-don't-have-time. You do, you're just not managing it properly. Scott Hanselman has two kids and he still programs the crap out of things. If all the programming you do is at work, and you legitimately don't want to program when you get home, see the section "Love your job and work on stuff you care about"?5 This goes past programming too. If you're an electrical engineer and a guitar player, make a guitar amp. If you're a carpenter, make a badass swingset for your kids. Just work on something that you want to do at home. If what you want to work on is what you're doing at work, then make like The Eagles and take it easy. Get shit done This is from Joel Spolsky. If you've ever seen a job posting for Fog Creek Software you'll see they really only care about two things: smart and gets things done. If you are those two things, it doesn't really matter if you are a python/django guy or gal, and they need somebody to work on their Wasabi based application; you'll pick it up pretty quick. It's sort of like going to work for a different carpentry shop and they say "hey, I know you're used to red hammers with leather grips, but here's a blue hammer with a badminton style grip." The language is basically just a tool, and if you're a smart cookie that doesn't screw around, the tool doesn't really matter. Stay organized Use a todo list or go farther and subscribe to the GTD philosophy. I tried the GTDthing, and I still sort of use parts of it, but I cram things into Remember The Milk to keep track of things I need to do, or want to do at some point. This gets things out of your head, and into something where you don't have to think about them all the time. I also use bug trackers to keep track of specific things on specific software projects I'm working on. Cut your losses I know you might want to push through on something, but some things just aren't worth doing or finishing. I had wanted to do a Gravatar clone using Rails 3 as an example application for when it first came out. It wasn't set in stone, just something I thought would be cool. But then Rails 3 was out, and I got sidetracked doing other things, and now it's taken a bit more hold. Me spending time on that application would kind of be a waste, considering Rails 3 has been out for a while, and my blog is also Rails 3 already. If an item has been in your todo list for a long time (maybe it was just a random thought), consider whether or not it still needs to be in there instead of just doing it. This also applies to things you've started, but have fizzled out. If it's not exciting or relevant anymore, scrap it and work on something fresh and awesome. Be asynchronous This one is weird, but I wanted to talk about it anyway. Actually use todo lists and RSS feeds. Like email, these are asynchronous systems. You send an email, subscribe to a feed, or write down a todo item, and you don't worry about it too much anymore. Sure, you check your email the next day or read your feeds before bed, but you don't have to keep checking a website for new content or be sitting staring at the "John is typing…" text on Skype. You can dedicate time to dealing with things, write them down when you think of them, and deal with them in the time you've set aside. The more you can get out of your brain into some other system the better. This allows you to focus on the task at hand. Later, when the time comes to deal with email, or read feeds, you can focus on that. These are some things that apply more to computer related fields , but I list them because they've really helped me out. Get a Kindle Seriously. This thing is awesome. It's beautiful to read, you can send other documents to it and have them converted (professional journal style papers in PDF form convert very nicely) for easy reading. The battery lasts forever, and Amazon's book selection is great. If you do a lot of reading, you need a Kindle. It's only $139! Use Google Docs All the little PDF whitepapers, ebooks, PDF manuals, everything I find on the net (reading or reference wise), goes into Google Docs. It's a great office suite of tools that works the same on all systems, so you don't have to deal with "oh I saved it on my Mac and now I'm on Windows" crap. It just works. Files are safe on Google's servers (I feel great about that, but you might have other opinions about keeping things in Google's system), and it's completely searchable. It's not only limited to the office suite things either. I store PDFs, important archives, or really anything that I want to be safe and accessible. It might not be the most useful thing in the world for you initially, but definitely check it out. Boom That's it. Those are all the secrets. Well they're not really secrets, but I think they're going to help me do great things in the software world. Maybe they can help you too. _________________________ About the Author This article was written by Daniel Huckstep of Verbose Logging. Daniel is a software problem solver in Edmonton, Alberta, Canada. He enjoys all kinds of programming, even assembly. see more. Related Topics:amazonbusinessFocuslanguagelifemeonlinespendingtechnology Continue Reading You may like Benjamin Kwan, Co-Founder of TravelClef Before you enter a Startup or before you choose your founding team or new hires read, "Entering Startupland" by Jeff Bussgang Nadia Al Sheikh, Founder & CEO of Flenco & Deal'n Women on Top in Tech – Morgan Berman, Founder/CEO at MilkCrate The Future of Personalised Learning William Sin, Director of Hallmark Jewellery Callum Connects Benjamin Kwan, Co-Founder of TravelClef Published 3 days ago on November 17, 2017 By Callum Laing Making music to create a life for his family, Benjamin Kwan, started an online tuition portal and his music business grew from there. What's your story? I am Benjamin and I'm the Co-Founder of TravelClef Group Pte Ltd, a travelling music school that conducts music classes in companies as well as team building with music programmes. We also run an online educational platform which matches private students to freelance music teachers. We also manufacture our own instruments. I started this company in 2011 when I was still a freshman at NUS, majoring in Mechanical Engineering. I was born to a lower income family, my father drove a taxi and was the sole breadwinner to a family of 7. I have always dreamed of becoming rich so that I could lessen the burden placed on my father and give my family a good life. After working really hard in my first semester at NUS, my results didn't reflect the hard work and effort I put in. At the same time, I was left with just $42 in my bank account and it suddenly dawned on me that if I were to graduate with mediocre results, I would probably end up with a mediocre salary as well. I knew I had to do something to gain control of my future. During that summer break, I read a book "Internet Riches" by Scott Fox and I knew that the only way I could ever start my own business with my last $42 would be to start an online business. That was how our online tuition portal started and after taking 4 days to learn Photoshop and website building on my own, I started the business. What excites you most about your industry? Music itself is a constant form of excitement to me as I have always been an avid lover of music. As one of the world's first travelling music schools, we are always very eager and excited to find innovative ways to a very traditional business model of a music teaching. What's your connection to Asia? I was born and raised in Singapore and I love the fact that despite our diversity in culture, there's always a common language that we share, music. Favourite city in Asia for business and why? Hands down, SINGAPORE! Although we are currently in talks to expand to other regions within Asia, Singapore is the best place for business. I have had friends asking me if they should consider venturing into entrepreneurship in Singapore, my answer is always a big fat YES! There's a low barrier of entry, and most importantly, the government is very supportive of entrepreneurship. What's the best piece of advice you ever received? I have been blessed by many people and mentors who constantly give me great advice but right now, I would say the best piece of advice that I received would be from Dr Patrick Liew who said, "Work on the business, not in it." This advice is constantly ringing in my head as I work towards scaling the business. Who inspires you? My dad. My dad has always been my inspiration in life, for the amount of sacrifices that he has made for the family and the love he has for us. He was the umbrella for all the storms that my family faced and we were always safe in his shelter. Although my dad passed away after a brief fight with colorectal cancer, the lessons that he imparted to me were very valuable as I build my own family and business. What have you just learnt recently that blew you away? You can not buy time, but you can spend money to save time! With this realisation, I was willing to allow myself to spend some money, in order to save more time. Like taking Grab/Uber to shuttle around instead of spending time travelling on public transport. While I spend more money on travelling, I save a lot more time! This doesn't mean that I spend lavishly and extravagantly, I am still generally prudent with my money. If you had your time again, what would you do differently? I would have taken more time to spend with my family and especially my father. While it is important to focus our time to build our businesses, we should always try our best to allocate family time. Because as an entrepreneur, there is no such thing as "after I finish my work," because our work is never finished. If our work finishes, the business is also finished. But our time with our family is always limited and no matter how much money and how many successes we achieve, we can never use it to trade back the time we have with our family. How do you unwind? I am a very simple man. I enjoy TV time with my wife and a simple dinner with my family and friends. Favourite Asian destination for relaxation? Why? Batam, it's close to Singapore and there's really nothing much to do except for massages and a relaxing resort life. If I travel to other countries for shopping or sightseeing, I am constantly thinking of business and how I can possibly expand to the country I am visiting. But while relaxing at the beach or at a massage, I tend to allow myself to drift into emptiness and just clear my mind of any thoughts. Everyone in business should read this book: Work The System, by Sam Carpenter. This book teaches entrepreneurs the importance of creating systems and how to leverage on systems to improve productivity and create more time. Shameless plug for your business: If you are looking for a team building programme that your colleagues will enjoy and your bosses will be happy with, you have to consider our programmes at TravelClef! While our programmes are guaranteed fun and engaging, it is also equipped with many team building deliverables and organizational skills. How can people connect with you? My email is [email protected] and I am very active on Facebook as well! https://www.facebook.com/benjamin.christian.kwan — This interview is part of the 'Callum Connect' series of more than 500 interviews Callum Laing is an entrepreneur and investor based in Singapore. He has previously started, built and sold half a dozen businesses and is now a Partner at Unity-Group Private Equity and Co-Founder of The Marketing Group PLC. He is the author two best selling books 'Progressive Partnerships' and 'Agglomerate'. Connect with Callum here: twitter.com/laingcallum linkedin.com/in/callumlaing Download free copies of his books here: www.callumlaing.com Continue Reading Entrepreneurship Before you enter a Startup or before you choose your founding team or new hires read, "Entering Startupland" by Jeff Bussgang Published 3 days ago on November 16, 2017 By Marion Neubronner Before you enter a Startup or before you choose your founding team or new hires read "Entering Startupland" by Jeff Bussgang. Jeff knows how to spot and groom good culture, as the book session was held in Zestfinance a company he invested in and now, "The Best Workplaces for Women" and for "The Best Workplaces for Tech", by Fortune. These are the questions during the Book Launch. How to know if a hire including the founder is Startup material? Jeff says to watch for these qualities. First, do the hires think like an owner? Second, do the hires test the limits, to see how things can it be done better? Are they problem solvers and are biased toward action? Do they like managing uncertainty and being comfortable with uncertainty? And comfortable with rapid decision-making? Are they comfortable with flexible enough to take in a series of undefined roles and task? How do we know if we are simply too corporate to be startup? Corporate mindsets more interested in going deep into a particular functional area? These corporate beings are more comfortable with clear and distinct lines of responsibility, control, and communication? They are more hesitant or unable to put in the extra effort because "it's not my job". If you do still want to enter a startup despite the very small gains at the onset, Jeff offers a few key considerations on how to pick a right one. He suggests you pick a city as each city has a different ecosystems stakeholders and funding sources and market strengths. You have to invest in the ecosystem and this is your due diligence. Understand it so you can find the best match when it arises. Next, to pick a domain, research and solidify your understanding with every informational interview and discussion you begin. Then, pick a stage you are willing to enter at. They are usually 1)in the Jungle, 2) the Dirt Road or 3) the Highway. The Jungle has 1-50 staff and no clear path with distractions everywhere and very tough conditions. The Dirt Road gets clearer but is definitely bumpy and windy. Well the Highway speaks for itself, doesn't it? Finally Please – Pick a winner! Ask people on the inside – the Venture Capitalists, the lawyers, the recruiters and evaluate the team quality like any venture capitalists would. Would you want to work for the team again and again? And is the startup working in a massive market? Is there a clear recurring business model? After you have picked a winning team and product, how would you get in through the door? You need to know that warm introductions have to be done. That's the way to get their attention. Startups value relationships and people as they need social capital to grow. If you have little experience or seemingly irrelevant experience, go bearing a gift. Jeff shared a story of a young ambitious and bright candidate with no tech experience who went and did a thorough customer survey of the users of the startup she intended to work with. She came with point-of-view and presented her findings, and they found in her, what they needed at that stage. She became their Director of Growth. Go in with the philosophy of adding value-add you can get any job you want. And as any true advisor would do, Jeff did not mince his words, when he reminded the audience that, "If you can't get introduced you may not be resourceful enough to be in startup." Startupland is not a Traditional Career or Learning Cycles Remember to see your career stage as a runs of 5 years, 8 or 10 – it is not a life long career. In Startup land consider each startup as a single career for you. Douglas Merrill, founder of Zestfinance added from his hard-earned experience that retention is a challenge. Startup Leaders to keep your people, do help them with the quick learning cycles. Essentially from Jungle to Dirt road, the transition can be rapid and so each communication model that starts and exists, gets changed quickly. Every twelve months, the communication model will have no choice but to break down and you have to reinvent the communication model. Be ready as a founder and be ready as a member of the startup. Another suggestion was to have no titles for first two years. So that everyone was hands-on and also able to move as one entity. Effective Startupland Leaders paint a Vision of the Future yet unseen. What I really enjoyed and resonated with as a coach and psychologist was how Douglas at the 10th hire thought very carefully what he was promising each of his new team member. He was reminded that startups die at their 10th and their 100th hires. He took some mindful down time and reflected. He then wrote a story for each person in his own team and literally wrote out what the company would look like and their individual part in it. In He writing each of the team members' stories into his vision and giving each person this story, it was a powerful communication piece. He definitely increased the touch points and communication here is the effective startup's leverage. Douglas and Jeff both suggested transparency from the onset. If you think like an owner and if you think of your founding team as problem solvers. Then getting transparent about financials with your team is probably a good idea. As a member of a startup, you should insist on knowing these things Such skills and domain knowledge will be valuable. There is now historical evidence of people leaving startups and being a successful founder themselves because they were in the financial trenches in their initial startup. Think Paypal and Facebook Mafia. What drives people to enter a startup? The whole nature of work is changing. Many are ready to pay to learn. Daniel Pink's book Drive showed how people are motivated by certain qualities like Mastery, Autonomy and Where your work fits into big picture. Startups do that naturally. There is a huge amount of passion and the quality of team today and as it grows then the quality of company changes. The Progress principle is in place, why people love their startup jobs is not money rather are my contributions being valued? Do I see a path of progress and do I have autonomy over work and am I treated well? Find out more about StartupLand on Amazon And learn from Zestfinance Continue Reading Latest Popular Callum Connects3 days ago Benjamin Kwan, Co-Founder of TravelClef Entrepreneurship3 days ago Before you enter a Startup or before you choose your founding team or new hires read, "Entering Startupland" by Jeff Bussgang Callum Connects4 days ago Nadia Al Sheikh, Founder & CEO of Flenco & Deal'n Entrepreneurship4 days ago Women on Top in Tech – Morgan Berman, Founder/CEO at MilkCrate Technology5 days ago The Future of Personalised Learning Entrepreneurship5 days ago William Sin, Director of Hallmark Jewellery Entrepreneurship4 weeks ago Entrepreneurs aren't making money. The system is broken. Entrepreneurship2 weeks ago Startups don't starve. They drown. A Lean Startup Perspective on Scaling Teams for IPO Callum Connects4 weeks ago Shaen Yeo, Founder of Positive Education Callum Connects3 weeks ago Gerald Ho, Founder of That Content Guy Media3 years ago Wise Leadership Media3 years ago Varun Agarwal, from failing in studies to founding a million-dollar company Media3 years ago The Next Tsunami – Asian Entrepreneurship Media3 years ago 7 Secrets That Made Steve Jobs Successful Innovative Asian Entrepreneurs3 years ago Joshua Hon, Founder Of Tern Bicycles Advertisement Trending Entrepreneurship5 days ago William Sin, Director of Hallmark Jewellery Entrepreneurship4 weeks ago Entrepreneurs aren't making money. The system is broken. Entrepreneurship2 weeks ago Startups don't starve. They drown. A Lean Startup Perspective on Scaling Teams for IPO Callum Connects4 weeks ago Shaen Yeo, Founder of Positive Education


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Experience the "Disney Difference" with an Adventures by Disney trip! Going on an Adventures by Disney trip is unlike any other vacation your family will take and most of that uniqueness comes from the "Disney Difference." What is Adventures by Disney? Members of our family have been on three different Adventures by Disney trips. We just returned from our first trip with the entire family for the Arizona/Utah itinerary where we visited Sedona, Grand Canyon, Monument Valley, and Arches National Park. Many of our friends think we're just going to Disneyland or Disney World and having an adventure....Read More


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Why the Bank of England Wants Inflation to Fall
The central bank said that the key reason for such sharp increase in prices was due to the depreciation of the British pound after the Brexit referendum.
Bank of England Raises Interest Rate to 0.50%
The BOE (Bank of England) in its November meeting increased its benchmark interest rates from 0.25% to 0.50%.
ADP: Expect a Positive Bounce in Jobs Data This Month
US private sector employment increased by 235,000 jobs in October. Non-farm jobs have bounced back from a downward revised 110,000 jobs in September.
Bank of Japan: No Changes in the October Policy Meeting
At its October policy meeting, the Bank of Japan left its ultra-loose monetary policy unchanged. The decision was made by an 8-1 majority vote.
Could Laggards Come Out as Winners?
As with most timeframes in the market, the laggards are a mix of surprising and obvious names (in hindsight, of course). This October, they stand out a little more than usual since so many asset classes are up this year.
Will Tax Cuts Bump Up Treasury Yields?
Since early September, US ten-year and longer-dated paper has been falling. Rates for the US government ten-year bond jumped from 2.04% on September 7 all the way to 2.36% on October 10.
How Weather Influences Natural Gas Prices
If, in real estate, everything is "location, location, location," then with natural gas investing, everything is "weather, weather, weather."
Are Gold Miners Besieged by Internal Issues?
Gold has had a solid year so far, up 13.5% through mid-October. And though it peaked in early September at over $1,350 per ounce, it had a quick drop back to $1,261 in early October only to bounce back over $1,300 in mid-October.
Analyzing the European Central Bank's October Statement
The reduction to the ECB's bond-buying program will likely have a mixed impact on the bond markets of countries in the European Union.
Update from the European Central Bank's October Policy Statement
In the ECB's (European Central Bank) October policy meeting, its laid out its plans for the QE (quantitative easing) program.
Will Bank of England Propel the British Pound Higher This Week?
The British pound (FXB) depreciated 0.46% against the US dollar (UUP) in the week ending October 27. The pound (GBB) closed for the week at 1.31.
Will the S&P 500 Index Have Another Positive Week?
For the week ending October 27, the S&P 500 Index (SPY) closed at 2,582, recording gains of 0.23% for the week.
Will Volatility Pick Up This Week?
In the week ending October 28, news related to developments surrounding tax reforms kept volatility at bay.
How Moat Indexes Performed in September
The US Moat Index has been performing fairly well this year. As of September 30, 2017, it has outperformed, rising 20.5% over the S&P 500 Index's (SPY) (SPX-INDEX) rise of 18.6% YTD.
Why Expectations for Business Conditions Fell 50% in September
The October Conference Board LEI reported that average consumer expectations for business conditions for September are 0.37 above the mean.
Are Declining Yield Spread Worries Done for Now?
At the last FOMC (Federal Open Market Committee) meeting on September 20, 2017, Fed members decided to initiate a balance sheet normalization process starting in October.
Understanding the Leading Credit Index for September 2017
The Leading Credit Index is an economic model that's modeled on the performance of six major financial market instruments.
Are Rising Equity Markets Signaling a Strong Business Cycle?
The S&P 500 (IVV) index has continued to break higher as hopes for tax reforms are being reignited by the Trump administration.
Is the Fall in Building Permits a Reason to Worry?
In September 2017, the number of building permits issued decreased from a revised figure of 1.27 billion in August to 1.22 billion.
More Positive News about New Orders
According to the October Conference Board LEI, core capital goods orders for September were valued at $37.85 billion compared to a revised reading of $38.0 billion in August.


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In the red corner
Following Johann Lamont's resignation last weekend, three contenders have thrown their hats into the ring to succeed her as leader of the Scottish Labour Party.
As expected, Jim Murphy MP has announced his intention to stand. In an interview with the Daily Record, he made it clear that he was "applying for the job of First Minister" and would seek election to Holyrood at the Scottish Parliament Election in 2016 or even "before then" suggesting he might be looking to get a seat ahead of 2016, possibly through a "swap" with Ken Macintosh MSP who holds the Holyrood equivalent constituency. Murphy is the frontrunner in the contest and will likely command the political (Ian Davidson MP exempt) and membership support.
Ahead of a speech in Glasgow on Saturday, where he will unveil a batch of supporters, he has pledged to listen to Scots demands for change, bring a fresh approach to social justice and ensure that the Scottish party is made more autonomous from London. James Kelly MSP and Jenny Marra MSP will lead Mr Murphy's campaign.
Murphy's announcement comes after Sarah Boyack MSP and Neil Findlay MSP had already thrown their hats into the ring. Findlay, the party's health spokesman, who had previously called on Gordon Brown MP to stand, will likely command strong support from the Unions and has emphasised the need to place social justice at the centre of everything the party does moving forward.
Meanwhile, Sarah Boyack MSP has emphasised her experience to lead. Although a Holyrood veteran, she does not enjoy the national profile of Jim Murphy. Interestingly, Boyack co-chaired with Murphy the last review of Scottish Labour, which brought in the idea of a leader for the entire Scottish party as opposed to just the MSPs – the issue at the centre of Lamont's resignation.
U-turn for Sarwar
Anas Sarwar, Scottish Labour's deputy leader has followed Johann Lamont out the door. In a turnaround from a statement earlier this week where he was adamant that he had no intention of stepping down, the MP for Glasgow Central confirmed that he will resign his post once a new Scottish leader is elected. In making the announcement at a gala dinner last night, Sarwar was keen to stress that he does not share Lamont's criticism of the UK Labour party (i.e. a branch office) and that his move was to allow the Scottish leadership to become more Holyrood focused.
The move means that Labour will avoid a Scottish top team dominated by Westminster if Jim Murphy MP is successful. The move also allows for an MSP to stand – a move Kezia Dugdale MSP is expected to do. Sarwar's resignation, combined with a Murphy victory, would also set off a minor reshuffle for Ed Miliband, with the Sarwar possibly heading to the Shadow Scotland brief and Margaret Curran MP moving over to the shadow international development portfolio.
EU Vote majority vote plea
Incoming First Minister, Nicola Sturgeon MSP has suggested that a majority vote in each nation that comprises the UK should be a legal requirement regarding any referendum on the UK leaving the European Union. The SNP are concerned that rising anti-EU sentiment elsewhere in the UK (notably southern England) could see the UK leave the EU despite Scotland potentially voting to stay.
David Cameron has promised an in-out vote on European Union membership if the Conservatives are re-elected next year.
Audit Scotland on the NHS in Scotland
Audit Scotland has published a report that concludes that the NHS in Scotland is finding it "increasingly difficult" to cope with the spiralling healthcare costs driven by an ageing population and the costs of drugs.
The report suggests that patients could face longer delays for hospital appointments despite legislation being past at Holyrood that gives a legal right to receive planned in-patient or day-case treatment within 12 weeks of the treatment being agreed. With budgets tightening at a time of increasing need, the report warns that it will be "challenging" for the NHS to make the changes demanded of it to meet the Scottish Government's vision for health and social care by 2020.
However, the report did have some positives. It concluded that good progress was being made towards improving outcomes for people with cancer or heart disease and in reducing healthcare associated infections.
Health Secretary Alex Neil responded that although the Government's ambition may need to be "refreshed" in the light of these findings, he was adamant that there would be no cuts to frontline spending.
Polling woes for Scottish Labour
Two polls published this week, have led to media hype that Labour could be all but "wiped out" in Scotland at the General Election in May. This is of course massively exaggerated given the need for a considerable uniform swing across Scotland and the entrenched nature of some majorities. Headline figures from the two polls gave the SNP a lead over Labour of 28 points (Ipsos-MORI) and 16 points (YouGov). However, what these polls do indicate is the massive mountain Labour and the other parties have to climb if they are to withstand the SNP's formidable electoral machine.