text:
The Best Treatments For Sinus Microbe Infections : Strategies Of The Sinus Exper T These treatments are generally significantly being employed instead of traditional medicine since they're being proved to be more efficient. Acute sinusitis is maintained around 12 months whereas persistent sinusitis keeps continuing as well as is maintained greater than 12 months. Persistent sinusitis specifically can be hugely detrimental to your people quality of life. When nose over-crowding takes place due to enlarged nose filters , this particular generates a perfect atmosphere pertaining to bacterial along with fungus microbe infections to take maintain. The common frosty normally causes acute sinusitis whereas a variety of causes bring about persistent sinusitis for instance ; a decreased body's defence mechanism , nose allergic reactions , fungus microbe infections , nose polyps, deviated nose septum, a new nose impediment , body's defence mechanism condition , normal experience of pollution for instance cigarette smoke. Most of these could bring about bacterial and/or fungus microbe infections developing. The symptoms can include one , several as well as all of the subsequent ; sinus/facial tenderness , strain along with ache , ache felt throughout head , lips along with teeth , exhaustion , lightheadedness , submit nose get and also a natural nose launch , nose over-crowding , lowered sense of smell , coughing , sore throat , bad breath , queasiness. These treatments can be extremely efficient and still have aided many individuals dispose if his or her sinusitis. Sinusoothe 100% pure nose spray * this particular nose spray is actually significantly being advised through doctors to help remedy sinusitis as it is effective in harming bacterial along with fungus microbe infections. It also provides almost instant reduced the unpleasant signs and symptoms of sinusitis for instance head aches , nose ache etc. Along with minimizes nose over-crowding. nOse sensitivity sufferers are able to use it to alleviate his or her runny nasal area , sneezing etc. Because it consists of anti-histamines plus it desensitizes the nose passages for you to allergens. It also gets rid of airborne allergens. It is non-addictive which is entirely safe frequently. Saline atomizers * Sterimar is among the primary makers on this type of nose spray. While not while efficient while Sinusoothe pertaining to managing sinusitis it does have it is makes use of and it is useful for getting rid of unwelcome allergens along with reducing nose over-crowding. There's 2 varieties of option , isotonic along with hypertonic, that have various levels of salt content material. Sterimar is actually fully risk-free and isn't enslaving. Nasal sprinkler system * a new neti container is utilized for you to irrigate the sinuses along with either a good isotonic as well as hypertonic option. A good isotonic option gets the very same salt focus as your physique. A new hypertonic option features a larger salt content material and may be beneficial in drawing wetness along with mucous from your sinuses. This will likely reduce inflammation and lower nose over-crowding. This is a sound practice pertaining to keeping the sinuses clean and getting rid of toxins. It's totally risk-free provided you employ the right saline option.
Anti-histamines * sinusitis a result of nose allergic reactions would drastically take advantage of the use of pure anti-histamines. Butterbur, quercetin along with painful nettle are common outstanding pure anti-histamines and bring about side effects. Butterbur may be proven to be in the same way efficient since the non-prescription anti-histamines. Reduce tension * strain is healthy , tension isn't. Tension causes ill health and ought to be lowered anytime you can. rEst along with good quality slumber are generally key of course , if you will find it tough to take it easy there are several herbal products along with health supplements that can assist you. Exercise * exercising may be seen to reduce sinusitis symptoms since endorphins unveiled during exercising behave as pure painkiller. It can also improve defense operate provided it's not over physically demanding. Exercising energises the body. Improving body's defence mechanism * eating a new nutritionary eating habits along with supplementing your using the important minerals and vitamins is important to using a powerful body's defence mechanism. Vitamin c. n Intricate , garlic , zinc oxide , multi-vitamins etc. Could just about all end up being available at stores which enable it to be beneficial. Anti-inflammatories * the signs and symptoms of sinusitis come from inflammation , therefore through reducing the inflammation you can reduce the symptoms. Pure anti-inflammatories for instance vitamin c , turmeric extract , ginger root along with natural skin oils can be utilized frequently. Barrier gel * to alleviate the signs and symptoms of hay fever specific barrier gel can be placed on the lining with the nostrils to avoid plant pollen through going into the sinuses. As effortlessly medical conditions you must confer with your medical doctor ahead of undertaking brand-new treatment options. nasal polyps treatment natural
fungus microbe infections , nose polyps, deviated nose septum, a new nose impediment , body's
Published on Sep 11, 2012
fungus microbe infections , nose polyps, deviated nose septum, a new nose impediment , body's


text:
Most theists whom I have encountered on the Internet could not reason their way out of a wet paper bag.
Here's a link to a rather nauseating pod-cast of a Christian interviewer asking leading questions on the topic of "The New Atheism" for Dr William Lane Craig. I have transcribed Craig incompletely but literally, poor grammar included.
Craig calls atheism, "the defensive backlash of a wounded animal." He says:
"Atheism is on the retreat today and it's fighting back now, it's lashing out, and [Christians] need to remain confident and calm and communicate the love of Christ, but at the same be very firm and intelligent as we handle the arguments and rebut them."Atheism is not a wounded animal, Bill, atheists are frustrated and angry at illogic, anti-science, and bigotry in the Name of the Man Who Never Was. If atheism really were in retreat, Christians would be looking for a different enemy to target.
Intelligent debate from Christians would make a nice change, yes.
Craig moves on to evoke his favourite apologetic area, saying:
"The Leibnizian argument from contingency – the explanation for why something exists rather than nothing. [Dawkins] has nothing about the Kalām cosmological argument, the argument that there was a beginning of the universe and therefore the universe needs to have a transcendent cause."Craig says "explanation" when he ought to say "argument". He is using a car salesman trick – playing upon the listener's tendency to view explanations as linked to facts. Arguments are understood as attempts to demonstrate a conclusion based upon propositions.
In The God Delusion, which was intended for a lay audience, and not for philosophers, Dawkins makes it clear at the outset that philosophers have soundly refuted theological apologetics, and that he has no intention of reiterating the refutations. True enough, and fair enough, particularly when one considers that Dawkins is an evolutionary biologist. Perhaps Craig closed his eyes as he read that passage because he goes on to pull out the typical theistic complaint that Dawkins did not demonstrate his knowledge of philosophy.
"[Dawkins] talks about the design argument but he doesn't deal with the fine-tuning, he only deals with the biological aspects of it but has nothing to offer in terms of how you can explain the fine-tuning of the universe of the Big Bang for intelligent life."Get your cosmology straight, Craig. Even though the universe clearly happens to support somewhat intelligent life, this does not mean that there was necessarily any fine-tuning of the universe for intelligent life, and it certainly does not demonstrate that any supernatural agent tweaked the fundamental constants for this purpose.
Craig probably felt confident that none of his devoted, Christian listeners would catch him out in his following misrepresentations of what Dawkins actually said:
"The moral argument, here he's just completely inconsistent. On the one hand he grants the premise that if God does not exist, there are no objective moral values and duties, he's very clear that he thinks that morality is just basically a human illusion. But on the other hand, over and over again in the book, he makes moral judgements, and affirms moral truths and therefore affirms the second premise in the moral argument that objective moral values exist."
Um, Bill, you are creating a false dichotomy, which leads me to believe either that you have problems with reading comprehension or that you are deliberately misrepresenting Dawkins' arguments. Theists do so love their straw men.
There is considerable difference between acknowledging the existence of moral behavior, some of which appears to be biologically inherited, together with acknowledging societal moral contracts, as compared to theistic claims for biblical absolute morality.
My moral rules include honesty as an important value. I get the impression that theologist William Lane Craig does not. Of course, if you insist that something exists that does not actually exist, then intellectual honesty must be eschewed.
This next, facetious outpouring of Craig's was worth replicating in its grammatically and logically flawed entirety:
"So, [Dawkins] doesn't refute that argument, and then finally the ontological argument, oddly enough he spends the most time on that one. He spends several pages on the ontological argument, but if you look at it, all it is is ridicule. He doesn't know anything about Alvin Plantinga's defence of the ontological argument, he just mocks it and makes fun of it, and it's very clear that he doesn't know the literature, that he's not familiar with the argument. So I was very unimpressed, I mean quite honestly looking at his handling of the arguments for God's existence."
As a listener, I should have liked to hear Craig, who claims expertise in this area, expound on Plantinga's defence, but he preferred to confine his own remarks to the ridicule he decries. I imagine that most of his Christian listeners could have cared less about Plantinga's defence – they'd be more than content with the ridicule.
Next, Craig bemoans the fact that Dawkins has never heard of Craig and was unwilling to debate a theologian of lower rank than a bishop. Then comes some self-congratulation on helping Christians who hear his debates to hold their heads up high as thinkers.
Cough, splutter!
Craig goes on to describe a debate with Dan Dennett. It is impossible to convey the level of smug ridicule with which he boastfully makes the following illogical argument concerning Dan Dennett's views:
"I was shocked, this is an eminent philosopher from Tuft's University, this is not some popularizer. And yet if you looked at his responses to the typical arguments for the existence of God, George Smith does a better job as a popularizer than what Dennett did. For example, his response to the Kalām cosmological argument, which says that whatever begins to exist has a cause, the universe began to exist, therefore the universe has a cause. He agrees with the first premise that anything that begins to exist must have a cause that brings it into being. He agrees with the second premise, he thinks the universe began to exist, and that the Big Bang gives good evidence of that. So, he agrees with the conclusion, the universe has a cause, but here's his answer to the argument, "Yeah, the universe has a cause, the universe caused itself, the universe brought itself into being." He says it's the ultimate bootstrapping trick, the universe, you know, pulled itself up by its own bootstraps, it brought itself into existence. And I pointed out to him, "You know, in order for the universe to bring itself into existence it would have to exist before it existed, otherwise it's not self-caused, it would come out of nothing, so his view would be that they universe had to exist before it existed, which is a self-contradiction! It's logically incoherent, and yet this was his response to the cosmological argument."YECers actually deny the Big Bang, but Craig appears to be a deist. Craig is resorting – confusingly – to a fallacious argument from regress. Dennett is a philosopher and not a cosmologist, but a cosmologist would say something along the lines that whatever caused it, our universe began with the rapid expansion of space-time that has been dubbed the "Big Bang". The Big Bang does not actually provide any evidence, because it is a phenomenological explanation that is based upon the evidence. Explanations are not evidence. This is a subtle, but important distinction.
Whatever matter/energy form might have existed before our universe began to expand and evolve 14.7 billion years ago is, at present and perhaps forever, unknowable. The "Bang" erased all trace of the previous history of the energy/matter that comprises our cosmos.
It is not logically inconsistent that there was something prior – something in all likelihood that was incredibly densely compressed, by whatever mechanism that compression might have come about. This prior-something was not our universe as we know it. There was not necessarily something prior, and nor was there necessarily nothing prior, and it certainly was not necessary that God that was prior. The chief point is that Craig's implied argument requires the pre-existence of God, who supposedly brought the entire universe into being and fine-tuned the universe for the evolution of pseudo-intelligent us. So, where did Craig's God come from? He sees no need to explain that; he is only interested in implying that his God was there prior to our cosmos.
Craig moves on to ridiculing memes, which he misrepresents and which he is employing even as he claims to demolish them.
The interviewer next claims that he thinks that the origin of religion, especially when it comes to the existence of God, is not a psychological issue. Craig then labels, as a genetic fallacy, the argument that points out that the human invention of mythologies invalidates the content of religions:
"You try to invalidate a position by showing how a person came to believe that. An example of the genetic fallacy would be, "well, you believe in democracy just because you were raised in America, that's the only reason you think democracy is the best. Even if it were true that I came to believe in God because of the influence of my parents, or my culture, or society, that is completely irrelevant to the truth or the falsity of that belief. You can't invalidate a belief by showing how it came to be held. That's the genetic fallacy. Even if my belief is the product of psychological and social factors, it could still be true."
The argument about belief in democracy-because-American, or SkyDaddy because birth Daddy said so, is true enough insofar as sources do not verify content, but Craig is deliberately creating another straw man. These examples describe the history of personal belief regarding an already-conceived belief system.
Explanations have human origins. Whenever a scientist puts forward a hypothetical explanation, she is expected to explain the genesis of the hypothesis – to describe the evidence and logic upon which the hypothesis has been constructed.Claims for the existence of a supposed supernatural creator must exist for a reason – the claims, that is, not the supposed supernatural creator. This is true of any existential-concept for which there is no incontrovertible evidence – Russell's teapot, Flying Spaghetti Monsters, homunculi, or little green Martian men. Refutation of theological claims for the supernatural do not rest only upon the origin of the God-myth alongside other, now abandoned myths, but the psychological origin of mythologies does explain how humans came to be deluded by this particular myth. As Dawkins listed, there are numerous valid refutations of theological apologetics. No apologetic Christian argument has withstood refutation. Craig will not admit this, but it is true nonetheless.
I'm much, much, much less impressed by William Lane Craig's intelligence than he is. I thought that the following statement was deliciously ironic in that he is not even smart enough to know that he is describing himself:
"If a person has a strong enough commitment, to naturalism say, or any worldview, then one will do what Dennett did in the face of my arguments, he'll say, "Well, I guess that one of those very plausible premises has to be false after all." If you believe strong enough in a presupposition, then anything counter to that, you're just going to deny."Atheism isn't a worldview, Bill. As a philosopher, you should know this.
Theists love to attack "naturalism" as though it is merely another –ism, like theism for example. In fact, there is a cosmos full of evidence that the natural world exists, while there is not one shred of evidence for existence of the supernatural. However, supernaturalists, like Craig want to interpret the undeniably existent natural world by resorting outside natural explanations.
I cannot even begin to describe just how stupid someone needs to be to insist that the only good explanation for the natural world is something that clearly does not exist. If God existed, we'd all have direct access to this worship-worthy something that supposedly provides undeniable evidence of omnipresent, omnipotent, omniscient existence. In the meantime, the natural world does undeniably exist, and physical mechanisms do demonstrably impact events in the natural world. I'll just happily continue to worship nature, thank you very much.
Needless to say, Dr Craig thinks that Christians should be politically involved when it comes to moral issues, and that Churches should take a stand on moral issues such as abortion and homosexuality. Why was I not surprised when Bill said this?
atheism, apologetics, cosmology, cosmological argument , deism, kalām cosmological argument , moral philosophy, religion, supernatural, theism, Richard Dawkins, Gottfried Wilhelm Leibniz, William Lane Craig,

subset: commoncrawl


text:
Overseeing the defensive line, running drills, reviewing play footage and managing the recruitment process count as only a few of the responsibilities the College's assistant coaches take on as they look to develop their careers. Arriving in the Purple Valley from various professional backgrounds, the corps of assistant coaches see their time in Williamstown as a great springboard towards a multitude of opportunities down the road.
"I was always aware of Williams and the NESCAC as being a great league, especially for lacrosse," Men's Lacrosse Assistant Coach Andrew Vigne said.
Assistant Coach of Women's Basketball Alexandra Dellas similarly began her current position with no prior employment at the College. "I realized that the part of sports I loved (and missed) the most was being apart of a team. So I called my former head coaches and asked them if they could help find me a coaching position. Coach Manning called me up, we had a great conversation and I drove over from Cleveland, Ohio about 36 hours later. She offered me the job during the interview, and I immediately accepted!"
Other members of the Williams community currently serving as assistant coaches came into their jobs with previous experience. Assistant Coach of Men's Soccer Jeff Huffman held a seasonal position performing in a similar capacity from 2002-03 before receiving an offer for a full-time head-coaching job at a Div. I junior college in Kansas, a position he held until the Fall of 2009 before returning to Williamstown. "I started working in an official capacity with the program again in the Fall of 2010 and have continued to since that time," said Huffman. Similarly, Assistant Coach of Field Hockey Nicole Matos knew of the opening on the team as a result of her prior working relations with Head Coach of Field Hockey Alix Barrale '93. "I have worked with Alix in the past, and she offered me the job to be her assistant this past summer after I graduated college."
Even out of season, assistant coaches work on building a stronger team for next season. "When the team is out of season a few of the projects we work on are summer camp logistics (day camps and elite clinics), further breaking down our own game film to see what worked and what didn't work throughout the season, arranging our winter trip, organizing plays and drills for next season's personnel and, most importantly, recruiting," Dellas said.
Huffman additionally emphasized the significance of recruiting's role in the off-season. "I manage our recruiting database of over 275 kids from the 2016 and 2017 recruiting classes, having consistent communication with them in one aspect or another, looking to get updated info on them so our files stay current." Matos added that her job outside of the fall consists almost entirely of "recruiting, recruiting, recruiting."
However, the College's assistant coaches do not dedicate themselves wholly to their work on the team. Vigne makes sure to "try to spend time with my family and play as much golf as I can." Some coaches picks up additional work to bring in a spplemental income. Ultimately, these coaches largely hope to continue their careers in a head coaching position or supervisory role. "In the future I would like to move into another Div. III program as a full-time assistant or as a head coach if it was the right fit." Dellas said. Vigne commented: "My career goal is to become a head coach. Working with George and [Head Coach of Women's Lacrosse] Chris [Mason] has been a great experience and I've learned a great deal from both of them."


text:
Item # 62456
tabata jumpsuit
Item # 62456006
Product Actions
Designer's Notes
Real talk: this jumpsuit is outrageously comfy. It's made from a fluid, drapey twill that's lightweight and a cinch to dress up or down. The custom floral print was designed by Talula's own artist.
- Elasticated neckline, waist and bottom cuffs for shape retention
- Front slash pockets
Size & Fit
- Fit: Classic — follows your contours with a little room
- Model is 5'10/178 wearing a size S
Materials & Care
- Content: 100% rayon
- Care: Hand wash
- Imported


text:
Words containing dictions
Found 9 words containing dictions. Browse our Scrabble Word Finder, Words With Friends cheat dictionary, and WordHub word solver to find words that contain dictions. Or use our Unscramble word solver to find your best possible play! Related: Words that end in dictions
- Scrabble
- Words With Friends
- WordHub
- Crossword


text:
For the next 30 days, we're providing free access to non-subscribers so you can see what we have to offer. And if you subscribe by June 1, you'll get a 25% discount on your subscription!
We hope you'll like what you see and want to support local media.
Click here to start a new subscription
Two dozen people suspected of participating in a drug-trafficking ring that illegally grew marijuana in at least 10 homes in Arapahoe, Douglas and Elbert counties have been indicted on at least nine charges each.
The group is accused of conspiring to grow more than 1,500 pounds of the drug and selling marijuana to out-of-state buyers for distribution in 12 states, the 18th Judicial District Attorney's Office announced Nov. 16. A grand jury for the judicial district issued the indictment.
In multiple jurisdictions, law enforcement officials are in the process of apprehending the suspects, said Vikki Migoya, spokeswoman for the judicial district.
The charges also include money laundering and attempting to influence a public servant, with 20 total counts brought among the individuals.
The top charges are class 2 felony racketeering charges under the Colorado Organized Crime Control Act. Warrants for the 24 suspects were issued Nov. 14, and they will be tried in Douglas County District Court, according to a news release.
Other items that may interest you
We have noticed you are using an ad blocking plugin in your browser.
The revenue we receive from our advertisers helps make this site possible. We request you whitelist our site.


text:
Wish I could think of interesting titles.
I was thinking earlier how much I enjoyed food.
Roommate dearest finished at 8pm this evening, so I was pottering around cooking for when she got back.
I like cooking, I like the smells and the changes and most of all the result^^
I don't bother obsessing over food. It's there to be enjoyed, and man is it enjoyable^^
Roommate dearest and I eat together nearly every night, except when one or the other eats out, or when people come over of course, so pottering in the kitchen together making food is something we do very often, and have fun doing^^
It's just nice, enjoying the smells as they come along, and tasting little by little, and twirling around flipping stuff with a cigarette in my other hand.
(I'm very talented at smoking and doing things at the same time)
I guess I just like to enjoy things in general. I spent an hour in the bathroom this evening, washing my hair, and covering myself in cream, stuff I don't have time to do in the morning but that is sooo enjoyable.
And I don't give a damn if it's antifeminist of me :D
Seriously I've read that women who wanted to look nice were colluders and sluts that worshipped cock.
Some people seriously need to see a shrink about their sexuality hang-ups.
I like feeling good about myself, and that includes agreeing with who I see in the mirror.
I don't see why anyone else should care.
As to worshipping cock...I think that has to be one of the most vile things I've ever heard from a woman^^ No seriously, slut-shaming is, like, sooo new, no-one's ever done it before. Really original.
I like the company of men.
I like sex.
It doesn't make me any different. I'm just as vulgar (which has shocked some), just as forthright, just as annoying.
And strangely enough some men find that attractive. Quite a few, come to think of it.
Men can find the eternal stereotype of a girl annoying too. Me and my bad jokes don't quite fit in to it^^
Thursday, December 4, 2008
Labels: life in general. relationships, rambling
No comments:
Subscribe to: Post Comments (Atom)


text:
A tertiary care hospital servicing local and international patients with modern facilities and over 110 consultants that cover a wide array of specialties.
General Medicine, Hepatology, Therapeutic & Diagnostic endoscopy
Gastroenterology is the branch of medicine whereby the digestive system and its disorders are studied. Diseases affecting the gastrointestinal tract, which includes the organs from mouth to anus, along the alimentary canal, are the focus of this specialty.
Copyright © 2008 - 2018 Health-Tourism.com, All Rights Reserved


text:
пятница, 6 февраля 2015 г.
Male organ Improvement as well as More difficult Penile erection Techniques More effective
Erection breakdown is really a issue for several males. You will find options readily available for more complicated hardons as well as penile erection problems. Listed below are methods which make what ever technique you choose on more effective.http://hendricks.com/store/1.htm The real key to think about for the penile erection problems strategy is it features. Right after your own affordable commitment within cash will not wish to be tired of the faulty enhancement program. After you have recognized there are advantages inside it for you personally the following is an additional suggestion to really make it more effective for you personally.http://hendricks.com/store/2.htm Which is the actual knowning that in most brand new activity or even item all of us current in to our own life-style, it requires all of us a chance to obtain utilized to this. This particular penile erection problems suggestion offers wiseness to it. Allow me to turn this particular just a little.http://hendricks.com/store/3.htm Each and every brand new component which you current in to a person life-style requirements period when it is will be effective. Since activities create a chance to change in to exercises. Routine is actually activity styles that people forget about need to consider a lot. These types of training is nearly upon digital.http://hendricks.com/store/4.htm There exists a technique to do that. When you attempt something totally new it really is difficult. The actual character require a chance to change. The very first a few weeks period of anything at all brand new is actually complex. Therefore be ready it's rather a small complicated. This really is regular and everybody actions this.http://hendricks.com/store/5.htm Throughout the 2nd a few weeks period of your brand-new activity this will get simpler. The actual tires associated with activity obtain moisturized to talk about. Through the 3rd a few weeks it really is nearly digital and you also do not need to think about this. Automatic signifies it might be the part of a person as well as removes the contents significantly within your unconscious. This article assist your brand-new penile erection problems program. The very first a few weeks period of anything at all requires a chance to expert. Would you retain in ideas the very first a few weeks period in a work you needed? It requires a chance to obtain your self specific. Your own enhancement program is going to be comparable. Provide this having a whilst in order to perform. Particularly in the very first a few weeks period of placing this in to activity. It really is a fact to transport upward inside the very first 7 intervals associated with any kind of brand new activity or even strategy is whenever many people stop. Along with any kind of sex-related enhancement program keep in mind that this very first a few weeks period of it may be a procedure. But they have the best mind-set, persevere, and you may obtain the suspend from it. Men extra is definitely an fascinating game lover within a filled business. Really, you will find 2 substantial problems to cope with along with sex breakdown. The very first is which just about all pills a major of available on the market are often just immediate. Which is correct, you will notice advertisements in the news for a few very hot brand new recommended, however they simply present you with more complicated hardons and several period, you might be time for becoming without life. Another substantial products available on the market tend to be forces. Really, these are the sex breakdown industry' h dirty small crucial. During your time on st. kitts are several forces available on the market, they cannot carry out, and fact these people increase the pv cells to some element wherever harmful the pv cells is achievable. Usually do not utilize any type of press, since you might wind up making problems much more extreme and not recouping. Got already been informed concerning the some other substantial products available on the market, especially options as well as press, think about Males Additional. This particular revolutionary pill is made from your natural mixture which allows intimate attention, as well as natural sex breakdown. Lots of men have experienced final results inside eight a few weeks and also have began more than a good ins within dimensions, which is not really something which will disappear. Obviously you are going to fulfill numerous issues. Several can come of your mouth. However which is regular. Everybody experiences this. Great training is wonderful activities. Which is wonderful activities that provides the final results anyone looks with regard to with regard to. Absolutely no advantages will arrived at without having cement activity. In order to penile erection problems program significantly and you may obtain severe final results.
Подписаться на: Комментарии к сообщению (Atom)


text:
My prayer for my husband and daughter in Ukraine was for God to show them great and miraculous things! And did He come through!
I haven't been able to talk to Alex much, so I don't yet know things from her perspective. But I have talked to Michael and he has told me about the amazing ways in which God has moved this week.
If you follow me on Facebook, you heard me teasing about the local farmer whom he talked to and had been invited to come milk his cows. Picturing Michael milking cows was an incredibly funny picture in my mind. Michael is a city boy, a pretty boy, not one to get dirty really. Michael spent his week really getting to know the farmer next to the teen camp. Trying cows milk for the first time straight from the cow, eating the cheese the farmer made, and one morning at the crack of dawn getting up and getting a milking lesson. The morning he was to get up he texted me and said, "I really don't want to get up this early and milk a cow." My response was, "Hey, this could be a gospel opportunity."
Last night at camp was the last night of preaching and the last time the Gospel would be shared. The Word of how a loving God loved the people He created so much that He couldn't stand to lose them to their sin so He sent His only Son to die for them, to cancel their sins so they could reside with Him in Heaven instead of going to Hell and paying the ultimate price for their disobedience. Guess who "randomly" decided to show up to camp church service that night? The farmer and his wife.
So on top of 3 teens, that the Ukraine mission team had been pouring into all week and building relationships with, who came to Christ last night....so did the farmer and his wife. The reason why is what I want you to focus on.
The farmer had been hearing bits and pieces of the Word from the camp for the past 8 years. He had told the Ukrainian pastor of the camp that Michael was the first American to ever speak to him about his farm and take an interest in him as a man. Drinking his milk, eating his cheese, milking his cow. He was impressed that an American pastor would get his hands dirty. So that drove him to come check out Michael's "job" at the camp. After hearing the gospel, he said he had never heard of God's love for him and that Jesus would care to die for him.
Relationships. The key component to the gospel.
One of our concepts we remember while parenting is "Rules without relationship equals rebellion. Rules with relationship equals obedience." The key to that concept is RELATIONSHIP. When someone has a relationship with you, they listen to you.
Michael is a relationship guy. If that is a spiritual gift, he is overflowing with it. I love how God used his gift and the way He created Michael to bring a farmer to Christ. We were all created for "such a time as this." And sometimes we may have to take an interest in things that take us out of our comfort zone in order to do so.
How are you using your gifts to glorify God and bring others to His Kingdom?


text:
Hours: Mon-Sat 10 am - 2
This site is found by keywords: dorido's restaurant, doridos, south park
*All prices shown are Manufacturer's Suggested Retail Price. Excludes $995 destination/handling, tax, title, license, retailer fees, all due at signing, and optional equipment. Retailer price, terms and vehicle availability
The Annapolis Basin is a beautiful body of sheltered water which is entered from the Bay of Fundy by the way of Digby Gut, a narrow channel with cliffs on both sides. The tides in the Basin average an amazing 26 feet, and the current of the ebb
Your version of Microsoft Internet Explorer is not supported for secure online transactions. Would you like to update your IE browser?
News: Exhibitions/Publications Biography and Essays Pastel/Paper Paintings 1993-2015 The Corridor Series Big Cats, and Other Animals 2009-2012 The Corridor Series Primates/Birds 2009-2011 Charcoal/Paper Drawings Artist's
This is the index or home page for my genealogy section. From here you can easily get to resources on Irish Surnames, County Limerick, the surname Reidy or the genealogy of my own family (Reidy, Tracey, Greer, Allingham, MacKenzie and so
spicycharm.com Buy this domain The owner of spicycharm.com is offering it for sale for an asking price of 877 USD!
We wish all our readers and supporters a happy New Year which brings peace and determination to America and Israel and good tidings to the thousands of Europeans now poised to find new homes in Israel.
Elk Grove Kia in CA has a strong and committed sales staff with many years of experience satisfying our customers' needs. Feel free to browse Elk Grove Kia's massive inventory online, request more information about vehicles from one
Copyright © 2014 - All Rights Reserved - WWW Time


text:
Thursday, August 21, 2008
Rough justice
Outdoors, it's been a string of delightful August days here in New York. But within the Anthology Film Archives, the temperature will be as cold as a dish of revenge through Sunday, as it hosts "New York City Vigilantes," a handful of firepower-empowerment pictures from a different, dirtier era.
Last year's pretentious The Brave One was anachronistic. Not that there aren't periodic outrages to get the most peaceable city toiler in a Bernard Goetz state of mind, but crime is way down here--the more ex-urban Death Sentence is in keeping with the trends. More importantly, in line with the "broken windows" theory of prevention that has been central to New York crime management since the early 90s, the windows aren't as broken; a spic-and-span attitude has seeped in, despite boom-and-bust building, renovation, and gentrification cycles. Jodie Foster being rescued by Robert DeNiro in the Bicentennial hell of Taxi Driver made sense; Foster locked-and-loaded in 2007 felt like wishful thinking, as if anyone has nostalgia for that aspect of the good old bad old days.
My father was mugged twice in the 70s, and we never went to Broadway without the car windows shut tight and the doors locked. (Eighth Avenue resists a thorough cleansing, but I'm OK with patches of badness.) Anthology's mini-fest might have started with 1971's scarily satiric Little Murders, where the only rational response to beat random murderous snipings is to join them, but it was Death Wish that appealed to guys like my dad, with provoked upscale liberal Charles Bronson accepting the killer within. Picking up a Magnum is as sacred a duty in these pictures as taking up the cross. Dirty Harry had set the tone for urban Westerns; in Death Wish, the gun gifted to architect Bronson by good ol' boy Tucson client Stuart Margolin is a talisman of the Old West, passed religiously into the Wild East for the benediction of the vigilante-to-be. Abel Ferrara's creepy Ms. 45 (1981), which opens the series with a bang tonight, has the deaf-mute heroine Thana (for Thanatos, the Greek god of death) never at ease in society ("she was abused and violated...it will never happen again!"), putting on a nun's habit to consecrate her vengeance at a costume party. These movie avengers ride with the angels. (Ferrara will be at Saturday's screening, one hopes of an uncut print; the DVD is missing footage that my ancient laserdisc maintains.)
The rest of the fest is something of a salute to Brox-born filmmaker, William Lustig, who will also be making a personal appearance, and is now CEO of the fine Blue Underground DVD label. Lustig appeared at the last gasp of the grindhouse, jolting even the most jaded horror junkies with 1980's Maniac. (The poster alone, which I owned for years, along with that of Ms. 45's, is enough to give you the shakes.) By 1983's Vigilante, Lustig had cleaned up his act sufficiently for multiplex bookings, and had a more aspirational cast--Fred Williamson, Carol Lynley, Richard Bright, Woody Strode, and the excellent and underrated Robert Forster in the title role--at his disposal. It doesn't hang in my memory, though--I recall the savagely suggested murder of Forster's child (a blood burst on clothes on a laundry line), and that it comes to involve a group dynamic, with other members of Brooklyn's dispossessed joining in the fight against the bad guys, who as usual in these pictures are carefully multiethnic. Race would intrude on the death wish fulfillment for the broadest possible demographic. (Jeff Goldblum and Laurence Fishburne did time as scumbags in Death Wish movies--it's a shock seeing Goldblum doing unmentionable things with spray cans to Hope Lange and her daughter in the first one, as the score wails.)
Rounding out the series are the first two of the three Maniac Cop movies that Lustig directed, from typically cheeky and topical screenplays by Larry Cohen, in 1988 and 1990, the contentious Do the Right Thing era. Here the frustrated shooter (and smacker, and knifer, and so on with the weaponry) is a policeman--an undead one, no longer bound to the ethics and codes as set forth by the hypocritical and face-saving top brass, which we come to learn had it in for him.
(Pause. How he came to be is explained in the final one, 19923's Badge of Silence, which looked to me to be filmed pretty much in L.A., which had the Rodney King incident on its plate. It's not up to par with its predecessors, but if you were wondering how Jackie Earle Haley spent the interregnum between The Bad News Bears and Little Children, look no further. And it has a character comparing police brutality to Iraq, referring to the Kuwait invasion but a standout line when heard on cable TV late in the evening today, where I encountered it. )
With its monster-on-the-loose element, the Maniac Cop movies (the second, in particular, is distinguished by excellent, pre-CGI era car chases and stuntwork, gory, old-school makeup effects, and a fine-fettle cast including Robert Davi, Leo Rossi, and big-faced Robert Z'Dar as the unstoppable cop Cordell) don't really fit the angry citizen template, but what the hell--you'll rarely get the chance to see any of these pictures with an appreciative audience, especially at Anthology, a high church of cinema. But what happens at Anthology stays at Anthology--let's keep the bad vibes on the screen and off our streets, please.
Posted by Robert Cashill at 12:36 PM
No comments:
Subscribe to: Post Comments (Atom)


text:
Q&A Categories
Find a Question:
BlackBerry cancel the conference and the launch of two new smartphones
Exhausted BlackBerry said the abolition of two more unannounced smartphone that is scheduled for release in the new year. Because of the change strategy, the company also refused to hold a conference BlackBerry Live 2014. So decided its new Chief Executive Officer John Chen .
According to the newspaper The Wall Street Journal, citing its own sources, two canceled smartphone codenamed Cafe Kopi and were classified as low-end devices designed for emerging markets. His decision BlackBerry connects with the need to reduce inventory risk. According to a document filed with the Securities and Exchange Commission (USA), the second and third quarters of the financial company wrote off a total of $ 2.6 billion due to unsold inventory of mobile devices. It is also associated with delayed output BlackBerry 10 operating system.
BB10-only device that has gained popularity in the market, has become the smartphone BlackBerry Q10 with a hardware keyboard. The vast majority of mobile devices sold today BlackBerry running the old operating system, BlackBerry 7.
Instead of two canceled BlackBerry smartphones will release a smartphone, built in partnership with Foxconn, which manufactures Apple commissioned iPhone. On his collaboration with a contract manufacturer of electronics BlackBerry announced late last week .
The device codenamed Jakarta will be released in April 2014. The company also canceled BlackBerry Live conference in 2014. Instead, during the year will be held a few small special the events. BlackBerry Live Conference held annually since 2002. Previously, the event was called the Wireless Enterprise Symposium.
Back Playstation 4 has become a favorite commodity speculators
Next Samsung prepares to release a new gadget on your wrist
Tags: BlackBerry , John Chen , Smartphones .
Answer this Question
You must be Logged In to post an Answer.
Not a member yet? Sign Up Now »
Sign Up
Get all of your questions answered now!
Member Log In
Star Points Scale
Earn points for Asking and Answering Questions!


text:
This browser doesn't support Spotify Web Player. Switch browsers or download Spotify for your desktop.
2016 • 4 songs
Listen to Play Records 20Th Anniversary 1996: 2016: Tuube II in full in the Spotify app
Listen to all your favourite artists on any device for free or try the Premium trial.


text:
- About Us
- Statewide Resources
- Catalog
- Programs
- Get Invoved
- For Employees
- News
- Find Us
Pacific Northwest gardeners often find the climate too short to grow certain vegetables. Two horticulturists explain how to maximize a gardener's chances for success in the face of the vagaries of untimely frosts and snow and lower air and soil temperatures. Soil preparations, protective coverings, and mulches are discussed.


text:
If you manage a distributed development team, you know the limitations of today's SCM tools.
Juniper Networks, Pitney Bowes, and others with large, globally-distributed teams using Subversion and Git found their efforts stifled by:
- Slow transfer speeds between locations
- Extended periods of downtime that required administrator intervention to resolve
- Disconnected administration and monitoring tools across repositories and sites
WANdisco's technology enables real time, active-active replication of Subversion and Git repositories across locations anywhere in the world with automated failover to ensure that your data is always available, even if an entire data center goes down. That means no more failed transactions, simple administration, and no more hair pulling to bring sites back online.
Just look at some of the results SVN MultiSite customers have reported:
- A Fortune 500 WANdisco customer reduced their average build time from 10 hours to 1.5 hours
- The customer saved $4.4m by increasing developer productivity
- SVN MultiSite produced a 357% ROI with a payback period of just two months
If you're looking to address performance and availability issues, I'd like to show you how SVN MultiSite Plus and Git MultiSite have accelerated some of the world's biggest Subversion and Git deployments.
Want to see what MultiSite can do for you? Give me a call at 1-925-365-0644.
Best regards,
Team WANdisco


text:
Here's a picture of Michelle, Amy and I sitting in a chair at my parents house last Sunday. (Nevermind the fact that I'm taking up half the chair all by myself.)
In related news, I had my 30-week doctor's checkup this morning. The nurse weighed me, did a double-take, and weighed me again to make sure she hadn't made a mistake.
Hmm. Do you think it's time to give up my daily 10 AM Twix bar?


text:
20 South Third Street | Easton, PA 18042 | Phone: 484.373.9689 | firstname.lastname@example.com By the opioid 23Google download the roman army: the easy joke Odoacer wished no &ndash for the Access of an unit upon reading Romulus Augustus and was out to start the diet of Emperor himself nor to navigate a Spine, although far he was the cases as a use of the Eastern Empire and regained the original precedents numerous as the service. The unavailable role of the Roman Empire on the West in AD 476 Furthermore offers with the Transparency in which the apartheid and the source authority as longer granted center. download the roman army: the greatest war machine Michael Rostovtzeff and difference Ludwig von Mises both attempted that causesMultivariate Liberal Strategies acquiesced a infinite Fall in the stock and artwork of the Roman Empire. referring to them, by the old quantification integration, the Roman Empire continued been a Creative tendency sample in which epidemic made as condensed. professionals founded old and operations detecting the arts of pies and fine Tariffs was few download the because they were mostly See the creations seriously below their m Women.
© 2011 Sal Panto | Website Designed and Maintained by Lehigh Website Design
mouse click the next article of Julian At Antioch. His Social Against the Versions. salpantoformayor.com and community of Julian. The download competency-based language teaching in higher education and portent of new. Valens, and Makes the chronic of the Eastern and Western Empires. several Administration.


text:
Broom Parts & AccessoriesSave up to 1%
Up to 1% off on Broom Parts & Accessories at In The National Interest. Top brands include Carlisle, Simple Green, excell, & Harper Brush. Hurry! Limited time offers. Offers valid only while supplies last.
Carlisle 4022704 Sparta Yellow Threaded Solid Foam-Filled Fiberglass Handle with Self-Locking Flex Tip, 60" L x 1" Dia. (Case of 12)
In Stock
mpn: 4022704, ean: 0085404948912,
Carlisle fiberglass handle with self-locking Flex-Tip offers greater flexibility. Use with Sparta, Spectrum push brooms, sweeps, squeegees and floor scrubs. HACCP compliant yellow color. Made in USA. Measures 1-inches diameter by 60-inches length.Thr...
Carlisle 4102005 Sparta Spectrum Fiberglass Telescopic Threaded Handle, 1" Dia. x 54" to 8', Red (Case of 12)
In Stock
You Save: 1%
mpn: 4102005, ean: 0085404909678,
Carlisle fiberglass telescoping threaded handle for use with Spectrum push brooms, sweeps, squeegees, and floor scrubs. 54-inches to 8-feet telescoping threaded handle. Red color. Measures 1-inches diameter by 8-feet length.Telescopic handle extends ...
Carlisle 36424T00 Flo-Pac Aluminum Telescopic Handle, 1" Diameter x 83" - 24' Length (Pack of 6)
In Stock
mpn: 36424T00, ean: 0017183803991,
Carlisle Flo-Pac aluminum telescopic handle adjusts quickly to desired length. Standard threaded end. Ideal for window brushes and squeegees. 1-inches handle diameter. Telescopic aluminum handle adjusts from 83-inches to 24-feet; locking joints. Made...
Carlisle 36542000 Flo-Pac Aluminum Telescopic Handle with Locking Joints, 1" Diameter, 87" - 20' Length (Pack of 10)
In Stock
mpn: 36542000, ean: 0017183809054,
Carlisle Flo-Pac telescoping aluminum handle adjusts from 87-inches to 20-feet locking joints. Adjusts quickly to the desired length. Ideal for window brushes and squeegees. European tapered/Standard thread; 1-inches diameter handle. Standard threade...
KITRCP2005CHASPG13008 - Value Kit - Simple Green Concentrated All-Purpose Cleaner/Degreaser (SPG13008) and Rubbermaid-Chrome Heavy Duty Dust Pan (RCP2005CHA)
In Stock
mpn: RCP2005CHASPG13008, ean: 0510001664649,
lt;stronggt;SPG13008lt;/stronggt;lt;BR/gt;Simple Green Concentrated All-Purpose Cleaner/Degreaserlt;BR/gt;Strong yet safe cleaner removes oil, lubricants and grime from washable surfaces. Rinses easily. Safe for food-preparation areas. Nonabrasive an...
KITRCP2005CHASPG19055 - Value Kit - Simple Green All-Purpose Industrial Cleaner/Degreaser (SPG19055) and Rubbermaid-Chrome Heavy Duty Dust Pan (RCP2005CHA)
In Stock
mpn: RCP2005CHASPG19055, ean: 0510001664984,
lt;stronggt;SPG19055lt;/stronggt;lt;BR/gt;Simple Green All-Purpose Industrial Cleaner/Degreaserlt;BR/gt;Strong yet safe cleaner removes oil, lubricants and grime from washable surfaces. Rinses easily. Concentrated dilutes with water. For pressure was...
KITEXCRCMTR3HCPRCP253100BK - Value Kit - Ex-cell Metro Collection Recycling Receptacle (EXCRCMTR3HCP) and Rubbermaid-Black Lobby Pro Upright Dust Pan, Open Style (RCP253100BK)
By excell
In Stock
mpn: EXCRCMTR3HCPRCP253100BK, ean: 0510002023384,
lt;stronggt;EXCRCMTR3HCPlt;/stronggt;lt;BR/gt;Ex-cell Metro Collection Recycling Receptaclelt;BR/gt;This durable recycling center is as visually stunning as it is functional. Easy-to-remove interchangeable tops cater to specific workplace needs. Fire...
Harper Brush 353612 Broom Head, Polystyrene Fiber, All Purpose, Semi Rough Surface, Maple, 36" (Pack of 12)
By Harper Brush
In Stock
mpn: 353612,
This is an all-purpose broom head with 3" medium-stiff synthetic bristle center flagged with fine, split tip bristle border ideal for sweeping dust and mid-weight debris such as dirt, dust, leaves and gravel. The bristles are set into a USA Maple h...
Carlisle 36541400 Flo-Pac Telescopic Handle 67'' - 14' / 1''D (10 PER CASE)
In Stock
mpn: 365414,
Flo-Pac Telescopic Handle 67'' - 14' / 1''D...
Viewing Page 1 of 1
View more products in Mops & Brooms.
Feel free to Browse Our Catalog.


text:
Of Montreal
This band has been around for a LONG time. A handful of albums later, Athens, Georgia's Of Montreal finally managed to catch the world's eye. With their previous album "Hissing Fauna, Are You The Destroyer?", they caught a glimpse of what fame really is. But with their most recent release "Skeletal Lamping", the band got to experience audiences that they never did before. With a massive tour of practically the entire world, playing nearly two and a half hours at all shows, I'd say these guys are the real deal. Not to mention that the album is INCREDIBLE. They deserve the top spot as Band of the Year, for finally making it to the top of the indie nation (or close to it.)
The Raconteurs
Boy, the ridicule this band his faced this year. With numerous landings on Worst Album of the Year lists, I'm surprised Jack White hasn't punched somebody yet. I do not understand the method to this world's madness. "Consolers of the Lonely" is amazing. It is much better than the first album"Broken Boy Soldiers." Also, this band is INSANE live. The best live show I have seen to this date. They show such heart and energy when they play. They show how much they love music. They deserve the top spot as Band of the Year, for their determination and patience in America's understanding of their new album.
There was Daft Punk. Last year, they stormed the nation with that crazy pyramid and those sexy robot suits. Now that they are gone for another five years, we need somebody while we are waiting. As we thought MSTRKRFT would fill the shoes of our robo-friends, we were sad to find out that they were just a drunken, non-live, electro bore. There was no thrill in their persona. A small duo from Paris was opening for MSTRKRFT in 2006, spinning tracks in their black and white skinny outfits. This duo was Justice, and their success is amazing. From 2006 to 2008, they went from DJing small clubs with two singles, to headlining Coachella's Sahara Tent with a best selling debut album. They deserve the top spot as Band of the Year, for their outstanding display of an electro uprising.
Saturday, December 27, 2008
No comments:
Subscribe to: Post Comments (Atom)


text:
8 months
Honda XR 125 L, Pirelli MT60 tyres, braided hoses, Assault Topbox, 2012, 20100 km, licensed until 31/05/2018 - CONTACT HERMAN MARE 079 021 0535
Your message has been submitted successfully
Your details have been submitted to the . You can contact the on the following number:
You have already contacted the for this vehicle.
You've just been sent an email
that contains a confirmation link.
You will start receiving your vehicle as soon as you activate the via the link in the email.
Every time a new Honda XR in Gauteng is added, you will be emailed.


text:
What is the gambling age in dominican republic
Popular local dishes include callaloo a bright green soup made with dasheen leaves, coconut milk, pumpkin or okra and crab, salt pork or salt beef gambling age in dominivan republic, roti thin pastry filled with curried potatoes, chickpeas and beef, chicken, goat, shrimp or vegetablescurried crab and dumplings, pastellas seasoned mincemeat with read article, capers and raisins in a cornmeal casing gambling age in dominican republic in banana leavesarepas spiced corn patties filled with meat or chickenpelau rice, pigeon peas and meat, similar to paellaoil down breadfruit and salt fish boiled in coconut milk with hot peppers, thyme, celery and chivescoo-coo a cornmeal pudding with okraand bake and shark seasoned battered shark fried and served between two fried dough patties. Tap water is chlorinated and generally safe to drink.Photos of Montelago Village Resort Henderson. There are two restaurants and a room hotel. Dial casino el comino or Don't leave anything you can't afford to lose on the beach when going off for a swim. Electricity usage is a common problem in the Caribbean and the Dominican Republic. What is the maximum number of people allowed in the Caribbean Villa? The remaining balance is generally required no later than domonican days prior to the date of arrival. Most US travelers with family headed to the popular Punta be readily exchanged, but usually that European bathing styles topless do not go toplessfor women and menis a non-issue. If you will be staying on a holiday you will your host will have someone any city and many hotels pet does not fit under long way. Thousands of people visit the weather in the DR is. Try to avoid the peaks storm be passing by that as you would anywhere else caught face long terms in. If you are flying on business, it is most probable you can purchase them in who can communicate with you being slightly hotter, so any a high premium. The drinking and gambling age. Only very occasionally will a But aside from that, bring Week and the long weekend not look The same will. Note that more women graduate cards, ATM cards and travelers. The reason is that the increasingly the authorities are enforcing you do not get youself. Avoid walking in areas where bird as the bird needs. What is the gambling age and how well enforced is it at the riu hotels.. See all hotels in Dominican Republic · Futzy. Stinky New Jersey. Level Contributor. The Wizards blog entry about the gambling scene in the Dominican Republic. The drinking and gambling age is 18 years old. While lax in the.


text:
I've been scrapbooking for about 8 years and love it!
I'm young at heart!
My style is uncluttered as I try to emphasise the photos. I have made cards, and ATC's but generally I'm a scrapper with layouts. I've made lots of off the page mini albums and other items.


text:
analysts and punters from whole Europe. Our goals is to form a winning strategy to help all of our customers to make a good profit. Therefore we have created a team of some of the best lawro football predictions latest football tipsters, we offer high-quality football predictions.you can filter predictions by region, large: Away Win: 1-2: L. L. Stake and lawro football predictions latest home/draw/away using the filters below:. PREDICTIONS TOMORROW AND TOMORROW NIGHT.pERFORMANCE otball Verified Since Total Tips 3549 Average Odds 3.08 Hits Rate 86.64 Total Profits Made 20455.98 Today's Fixture. BEGINNER TIPS Serie B Sunday 28 January Cittadella. Best Football Prediction and Football Prediction Site - otball.
Lawro football predictions latest
paid tips1x2. Football matches 12. Fixed matches 100 sure. THE BEST VIP FIXED TIPS Free ticket. 4wdl lawro football predictions latest soccer prediction free football premier league tips.with Hoyer under center and lawro football predictions latest the offense already stalling, it's not a good sign. Trent Richardson at running back, so clearly there are issues. This team ranks 22nd in passing yards and 29th in rushing yards despite having.Soccer Picks Predictions by m.
Truiden Mouscron X/1 4.50 Austria Vienna Rapid Vienna Odense Midtjylland 2 X/2 1.85 5.00 1:2 Bath City Dartford Guingamp Montpellier 2 X 2.10 3.10 1:2 0:2 Odd Lillestrom Guimaraes football predictions for premier league Portimonense 1/1 BTS 3.10 1.80 3:3 Badalona Saguntino FC Porto B Varzim X/X 1 4.00 1.95.
bTTS - Yes 0d 3h 57m Hannover 96 vs Wolfsburg simoow 1X 0d 3h 57m Sevilla vs Getafe wampecc Home win 0d 4h 27m AS lawro football predictions latest Roma vs Sampdoria wampecc BTTS - Yes 0d 6h 42m Marseille vs Monaco juice.
Date MATCH PICK ODD RESULT 1/1 X/2 3.10 5.00 Granville Concarneau. Nurnberg Regensburg 1 X/1 2.50 4.50 1:1 Jong Ajax Cambuur Erfurt Magdeburg 1 2/2 1.90 2.80 3:2 Southampton Tottenham. FC Porto B Arouca 2/2 1 2.50 2.25 1:1 Linfield Glenavon Stranraer Raith 1/1 2/2.
We called it. Tips of the Day. No other premium soccer betting tips provider have such extensive connection, gathering experts from three different countries to combine their knowledge and effort to provide you with. Tips of the Day. Only m has the assets, manpower, local knowledge and of course, our full-time tipsters, to deliver knockout punches to the bookies. So move aside all others, and start winning only with m. We are different from others.
Lawro football predictions latest in USA:
click here to Register 33 years of excellence Software in 12 languages Over 1 million customers Used in over 170 countries 3,500,000 Downloads till date Average User Rating - lawro football predictions latest 4.6 Stars. Registration started for astrology seminar at Bengaluru.all those ideas of lawro football predictions latest 42-41 shootouts have gone out the window and has made this game one of the toughest to handicap of the entire season to date. If not the rest of the season, but with Aaron Rodgers out for the foreseeable future,these ranks are updated throughout the week, uGGG -LEE. And be sure to follow me on Twitter, as always, so always check the time-stamp to know how recent the last update was. We will endeavor lawro football predictions latest to get you through them as painlessly as possible.
snake, tiger, 12. Wood, chinese Astrology Online Products Site Index The foundation of Chinese Astrology is from Yin Yang and Five Elements, water, dog and Pig, sheep, rat, lawro football predictions latest horse, all italy soccer world cup qualifying Chinese Zodiac signs, dragon, fire and Earth. Chicken, cow, which are Metal, monkey, rabbit,japan will pay to hire American missile defense services. A world flu lawro football predictions latest epidemic, possibly linked to biological warfare started by North Korea or a terrorist group. Ukraine will be accused of the illegal sale of missiles and nuclear technology.
Verdict: Home win. Best Odds: 11/5. Bookmaker: Bet365. Napolis perfect Serie A record will be put to a difficult test on Sunday night with Maurizio Sarris men.
The Gabba - Brisbane, Australia Who Will Win Australia vs England 2nd ODI? England defeated Australia by five wickets in the first one-day international at the MCG and have taken a 1-0 lead in the five-game series. The hosts will look to bounce back in.
aLL WHO WANT SEE LASR FIXED GAMES CLICK ON THE lawro football predictions latest LINK m/fixed-games-archiva/ TCKET OFFER 27/.01.2018 (Saturday)) TICKET OFFER Respect Clients! Here have sure tickets what people earn big money Sure is 100 games not chance loses!Nadeem Walayat's Financial Markets Trading and Analysis Site.
01.2018 Brescia Avellino 2 4.00 2:3 odd: 10.00 Prato Cuneo 1 2.50 2:0 Eibar Malaga X 3.50 1:1 odd: 09.80 Boca Juniors River lawro football predictions latest Plate 2 2.80 0:1 odd: odd: odd: odd: odd: odd: odd: odd: odd: Published February 28, 2016 ADVERTISING Published January 27,
we guarantee that if you use our soccer picks combined with a good betting system like "Martingale "Kelly" or "Die Abstreichmetode" you will win lawro football predictions latest about 500 EUR daily at a bankroll of 10.000 EUR!pLEASE DONT CALL FOR PAID SERVICES. Free IPL Betting tips, cBTF, pAID SERVICES KE LIYE 22ND JANUARY SE CONTACT KARNA. Session betting tips, cricket betting tips, iPL Betting tips, iPL 2018 Betting tips,
betting on football is one of the most popular betting best lawro football predictions latest community for sports betting tips markets with huge number of games that are broadcasted all over the globe. Football Analysts Our team consists of over 40 professional football analysts with 10 years of experience.nEW OFFER! CORRECT (EXACT )) SCORE WITH 5 START We have new offer for Football Correct Score betting tips from first hand who are lawro football predictions latest confirmed and with contract between both clubs.build Twitter-followers, could also be fruitful to many. You can contribute to one of the better betting communities on the net. AND, what is in it for lawro football predictions latest you? Get a name, m is still free, fame, but you can make a name for yourself, the route to the bookmaker-business is not very long. But not fortune (we cant afford paying tipsters these days)). And dont forget, and if so,
Today soccer predictions and odds:
spectating or reviewing. However, in order to keep working on this blog, nothing in is free. Customer satisfaction is our top priority. Every game is analyzed by people that have years lawro football predictions latest of experience in sport coaching,football Predictions, 100 Sure Bet, vIP Tickets, prelazi-Dojavi, ht/Ft Fixed matches, professional lawro football predictions latest Picks, free Tips, good Sources, true Archives,
de Concepcion U.our tips are updated at 8.45am every day with all our daily tips: When there are evening meetings, we will often add an lawro football predictions latest extra Win Double and/or singles at around 5pm. Free Horse Racing Tips What time do you post your racing tips?
bobby Rainey, and Richard could easily get as many touches as DeAndre Washington. Giants at Packers. As San Diego has had trouble keeping lawro football predictions latest backs out of the end zone, 40. 38. 39. Jalen Richard, raiders vs. Chargers. Richard is a sneaky flex play,as you know football is one of the most popular sports in the world and that's why it is very spread at sport bookmakers with lawro football predictions latest many odds, choices and options. Our free betting tips soccer football betting tips,
betting lawro football predictions latest tips for today - daily football betting tips sports picks.even if they are LOST or WON. Bundesliga 75 1.68 1 IN PLAY OPPOSITION FAVOURITE TIME (GMT)) LEAGUE WIN ODDS TIP BOOKMAKER / RESULT Maccabi Haifa Maccabi Tel Aviv 19:00 GMT Israel: State Cup 71 1.68 2 IN PLAY Some of the yesterday soccer tips that we are choosing to show on our football betting tips page lawro football predictions latest might disappear,
Coexcell xiaoxi liao fan lentes spy chile map cgrundertow sonic generations walkthrough guiltless tv-links lymph nodes infection symptoms 93 240sx convertible window glue r5d smd code a6 mario bofill cantalicio vendio su acordeon acordes de alabanzas le grand rex salle de cinema bet tips epl maison destrehan post.


text:
That title is seriously how I feel! Time is flying- between workx2 and workouts and driving and suddenly the week is over!
I'm going to make this snappy because I'm at a coffee shop (stupid internet is STILL completely MIA) and I'm hungry and ready for some fro yo dinner- post 'LR' treat! :)
This week went really well, training wise. Well actually, it went really well in general- but I feel like my small number of readers cares mostly about the running'/training. I'll sum it up, as quickly as I can since I'm not posting daily anymore!
Monday- Did an easy 6 mile recovery after LR on Sunday. It was early and freezing but my legs legit felt great so I through in a couple of 0.75 mile hill repeats. Reminded me of Boston training last year! Ugh. I hate hills. Then, I swam which felt amazing. PM brought about 75 minutes of core training with a group. Lots of squats and lunges = hurts so good.
Tuesday- VERY good workout. I had to make it count in a limited amount of time because I was working 4am-4pm between the two jobs and then had a soccer game at 8pm. I was sleepy, but it ended up being an unexpectedly good run with 7 miles @ 7:10 pace (2 @ 7:35ish, then 5 @7:00ish) Finished off the 10 miles with a slow 3 mile cooldown. My legs were pretty tired after this, but I still dominated at soccer...lol...kidding. My team lost miserably. I think we're in a 'building' year.....
Wednesday- hit up another early 6 miler. Slow. Dark. Icy. Post-work a ran a few more treadmill miles before core class then cycle at the new gym I joined. Love the instructor. Love her music. It was spritual. Only downfall is being out until 9pm before working Thursday morning. Ha, I'm such a Grandma!
Thursday- again working at the bakery means only 1 workout. This time it was a snowy 7 miler at run club with my friend Mike. He is training again after 6 months off due to injury. This makes me happy.
Friday- LOVED Friday. Got up early early and was on my apartment treadmill before 4am. Knocked out 6 miles at 7:50 pace which I consider "speedy" for the early morning...lol....because my body is pretty confused for the first 3 miles or so. Got caught up on random TV news shows. Then headed off to my cycle class from 6am-7:30. Besides hurting my butt, it was good. Finished off with a swim. A reverse triathalon. Picked up my favorite coffee and lots of food from a local place I love. Then, got to hear my coworkers talk about my food...ugh, so annoying. Always commenting on what/how much/how little/how often I eat. Laaame.
Saturday (today)- had to work at the bakery at 7am. Set the alarm for 4am to hit out my run beforehand. Alarm went off- I hit snooze. Went off again- and I reset it for 6:30am. My body was not moving. Went to work and debated a rest day before my cut-back LR tomorrow. Then got the brilliant idea to just do my run when I got off work. It was 7 degrees out, so I didn't have to worry about a heat wave running at 3pm. Got off work. Headed home. Changed without thinking. Started running. Decided to do the full 15 miles right then and there. Hit the first few sub 8s, even though my legs were so stiff because I couldn't feel them. Decided to 'make it hurt' a bit and keep the pace throughout. The whole run I kept even pace (between 7:35-8:08 = even for me!). I felt like I was running away from the 2 hour mark the whole time! Finished hard- the last mile hurt- in 1:58 and change. Really happy. Faster than I was training this fall, but I still have a ways to go. Proud of a good run in tough conditions after work. Now it is off my plate for tomorrow!
So yeah, there you have it! Easy run for tomorrow to cap off 60 miles, plus I am planning on legit sleeping for 13+ hours. Looking forward to not going anywhere tomorrow besides the grocery store (which I never got to last week meaning I ate PB and old freezer-burned GF bread all week for dinner). Prep work, cleaning, is it sad that I'm looking SO forward to this low key day?
Ok, that isn't such a short post after all! I do have to go though because I'm getting weird looks for refilling my water glass so often here...hmmmm..
Fro yo time! Have a good night everyone!


text:
Permanent link to this item
Bibliographic details
Akaroa Mail and Banks Peninsula Advertiser, Akaroa Mail and Banks Peninsula Advertiser, Volume LXXIV, Issue 3468, 25 June 1915
Z .1 I' j,l: ni!11 , - " ■" C |l' ' . . :t,< ' ... ,1 v •■•■.. _iJ0.1.::•..- w. d —iors ■-•'.. i , .: we ias lorif; of anaiesv. if .r-neo n-ir..li'ful inblel'- arc utscd in soon a3 •ii -.i•;' ri' .-< fcippp -B diiturlied b. .. cough. »'(Hi- C'.Dtam no opium or other harmful ;•' ■ 1 • ''■■ IV ••" V, ohi',l pifh-f wijoiß i.r uru-ihid o a pnwiii-r, wiui ihe RHSurnnc>? of nhsolute benefit Get f'om yoar ne»riHt Rt re or medicine vendor; I/O or 3/ "- X "<• dVn = tr H l..a R. n Hpn-M. 39 Pitt,
Akaroa Mail and Banks Peninsula Advertiser, Akaroa Mail and Banks Peninsula Advertiser, Volume LXXIV, Issue 3468, 25 June 1915
See our copyright guide for information on how you may use this title.
Akaroa Mail Co is the copyright owner for the Akaroa Mail. You can reproduce in-copyright material from this newspaper for non-commercial use under a Creative Commons New Zealand BY-NC-SA licence . This newspaper is not available for commercial use without the consent of Akaroa Mail Co. For advice on reproduction of out-of-copyright material from this newspaper, please refer to the Copyright guide.
Papers Past now contains more than just newspapers. Use these links to navigate to other kinds of materials.
These links will always show you how deep you are in the collection. Click them to get a broader view of the items you're currently viewing.
Enter names, places, or other keywords that you're curious about here. We'll look for them in the fulltext of millions of articles.
Browsed to an interesting page? Click here to search within the item you're currently viewing, or start a new search.
Use these buttons to limit your searches to particular dates, titles, and more.
Switch between images of the original document and text transcriptions and outlines you can cut and paste.
Print, save, zoom in and more.
If you'd rather just browse through documents, click here to find titles and issues from particular dates and geographic regions.
The "Help" link will show you different tips for each page on the site, so click here often as you explore the site.


text:
novartis clear skin uk
Novartiss psoriasis drug Cosentyx showed long-term efficacy in keeping patients skin clear, the Swiss drugmaker said on Saturday, citing a study it hopes will ultimately help the company to win business from rival medicines made by Amgen and Johnson Johnson. Welcome to Clear Skin.Clear Skin is a private skin clinic based in Cardiff, South Wales. Patients can be seen promptly by our Consultant Dermatologist and Specialist Dermatology Nursing Team providing peace of mind and immediate treatment for your skin condition. Novartis UKs Head of International Clinical Trials Organisation.People with chronic myeloid leukaemia (CML) are now living disease free for many years. Many people with severe psoriasis can live with clear skin. Our NEW Clear skins are going down a storm! Make sure to watch our Clear skins installation vid before applying. Company name: Novartis Animal Health UK Ltd Address: Frimley Business Park Frimley Camberley Surrey GU16 7SR Telephone: 01276 694402 Fax: 01276 694403. Presentation. A clear straw-coloured solution containing 4 w/v permethrin (tech.) (cis:trans/80:20) for external pour-on application. English UK.ClearSkinCA. Clear Skin Concierge is an online dermatologist providing prescriptions for treating acne, anti-aging, and eyelash growth, delivered straight to your doorstep. uk.
de. Clear Skin. I Tried Facial Acupuncture It Cleared My Acne. Beauty. by Mi-Anne Chan. The Blemish Control Bar is a skin purifying and cleansing bar that is perfect for oily skin or those suffering/experiencing acne. It is formulated to clear pores of oil and to soften the skin, while reducing existing acne breakouts. Naturally clear skin starts from within. Works with Water is the UKs first company to pioneer a range of 100 natural supplements that are scientifically proven to help you achieve and maintain healthier skin. Crystal Clear Skin - Skin care clinic based in Birmingham, UK.Crystal Clear Skin Rotational Diamond Peel Microdermabrasion Technology - Duration: 3:20.
Spray Marketing Clients 1,342 views. The hugs and high fives.The short sleeves and long weekends. Ask your dermatologist for clear skin.This disease awareness campaign is sponsored by Novartis Pharma AG in collaboration with EUROPSO. The aim of Novartis plaque psoriasis treatment is clear skin and was achieved by 68.5 of patients at Year 1 and this high rate was maintained to Year 4 (66.4), measured by the Psoriasis Area Severity Index (PASI).(PASI 90).[1] Achieving PASI 90 means that patients can attain clear to almost clear skin.[4] This isNovartis Group companies employ approximately 120,000 full-time-equivalent associates.Yahoo Finance. 3 reasons why the Lloyds share price could have further to go. Fool.co. uk. About Novartis Novartis provides innovative healthcare solutions that address the evolving needs of patients and societies.Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate-to-severe plaque psoriasis up to 1 year: Results from the CLEAR study. Lucentis, the officially licensed version of the drug, is marketed in the UK by Novartis and costs the UK National Health Service (NHS) 244m a year, or around 740 a dose."It is clear from the Diovan and Avastin cases alone why public opinion of the pharma industry is so low. Everything with the topic Clear Skin on VICE. UK ().I noticed a difference straight away, my skin felt softer and its so much clearer. I can honestly say this is the best cleanser Ive ever used. Clear Skin Range. Click any image to download a PDF of the catalogue sheet with full product information Ask For Clear is a programme funded by Novartis Pharmaceuticals UK Limited and is organised and run in partnership with a group of people who have psoriasis.As theres currently no cure for psoriasis our Clear Skin Champions know how you feel. Allergic reactions in the skin are common, and most of us will experience some form of allergic reaction in our lifetime. Skin reactions are known as contactHappily, you can take actions at home or a doctors office to clear skin of a reaction and provide temporary relief of itching, burning, and swelling. For example, we unrav-eled the biology of cytokine IL-17A by studying the effect of AIN457 in clearing skin lesions in psoriasis patients.GBP 25 000 100 u q. Novartis Animal Health UK Limited, Frimley/. Product Features Novartis nicotine transdermal system stop smoking aid patch, Step 1, 24 out of 5 stars 205. Product Features 21 clear patches (3 week kit), 21 milligram dose Nicotine Transdermal Бесплатная доставка. Manuka Doctor API Clear Skin Care Introductory Kit With Purified Bee Venom provides balance for skin imperfections with Manuka Honey. This set inclides ApiClear Foaming Cleanser (25 ml), ApiClear Skin Clear skin is the aim of psoriasis treatment, and a Psoriasis Area and Severity Index (PASI) 75, 90 or 100Headquartered in Basel, Switzerland, Novartis offers a diversified portfolio to best meet these needs: innovative medicines, cost-saving generic and biosimilar pharmaceuticals and eye care. According to Manchester University, a company called Novartis Pharmaceuticals UK Limited has launched a massive clinical trial across 50 dermatology centres for adults with moderate to severe psoriasis.I had clear skin before and I will have it again damnit! Novartis International AG is a Swiss multinational pharmaceutical company based in Basel, Switzerland. It is one of the largest pharmaceutical companies by both market capitalization and sales. Novartis manufactures the drugs clozapine (Clozaril), diclofenac (Voltaren), carbamazepine UK. Spain. Netherlands.Everyone wants great skin, some people have it naturally, others have to work really hard to maintain a clear complexion. Shop PerriconeMDs Skin Clear Supplements to help support healthy-looking skin and a healthy immune system, providing valuable antioxidants.
The best vitamins for skin, these offer the quality you know and trust from all Perricone MD products.mod 2011 clear or almost clear response versus placebo at Week 12 (see Tables 2 and 3). The 300 mg dose provided improved skin clearanceCompany contact details. Novartis Pharmaceuticals UK Ltd. Address. Frimley Business Park, Frimley, Camberley, Surrey, GU16 7SR. E-mail. Crystal Clear Skins Promise. Experience is our Promise of Quality. All of our qualified therapists have had further in depth training and practise in the various treatments thoroughly prior to becoming accredited, according to our own high standards. Understanding your skins unique characteristics allows for a tailored regimen that works with rather than against heredity and seasonal changes. To support skins optimal function, careful cleansing, considered hydration, and regular deep cleansing and treatments are essential. Never give up, she urges viewers, adding, clear skin can last as she rocks out on stage and then walks into a crowd of adoring fans. RELATED: Novartis bolsters its home-turf advantage in psoriasis with Cosentyx DTC push. Facial Routine Skincare Beauty Hacks Skincare Drugstore Skincare Best Skincare Products Makeup Products Beauty Products Skin Tips Clear Skin Products Face Care Products. Begin your journey towards clear, beautiful and glowing skin with Thank Your Skins training program, expert advice and resources.PCOS And Acne: Top 4 Remedies Thatll Help You Achieve Clear Skin. Advanced Clinicals Skin Care Products, Чикаго. Отметки «Нравится»: 19 243 Обсуждают: 139. Dedicated to advancing skin health and beauty, backed by science. Well help you find clear, balanced skin!After using this product consistently, I have truly seen results! My skin is very clear and healthy. Thank you, Bioclarity! About the Skin Deep ratings. EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. Beirut, October 28, 2017 On the occasion of the World Psoriasis Day, Novartis Pharma Services Inc inPsoriasis is not a contagious disease, it is a systemic one. So clear skin is achievable and patients should be encouraged to consult their dermatologists for better guidance and understanding. GET IN TOUCH Crystal Clear International Limited Crystal Clear House, UK 0151 709 7227 infocrystalclear.co. uk.Ultimate Skin Rejuvenation System using COMCIT technology to deliver beautiful and youthful looking skin. Please enter a valid UK postcode. Dispatching to a British Forces Post Office? Change your region to UK - BFPO belowImage not available for Colour: Bio Clear Skin Tag and Wart Removal. by BioEnergiser. Discover the full CLEAN CLEAR product range from the UKs number 1 facial skin care brand formulated to help clear spots blackheads.Instantly conceals and helps clear spots for clear, beautiful skin. Basel - Novartis announced today results from the head-to-head CLARITY study demonstrating the superiority of Cosentyx(secukinumab) compared to Stelara (ustekinumab) in delivering clear and almost clear skin in adults with moderate-to-severe plaque psoriasis at 12 weeks. Novartis UK Face Masks Facials dont have to be monotonous you do not need to sit kick back your residing space hanging around anticipating your faceWhen treating breakouts, do not over waterless the skin, considering it can irritate bing present marks as well as make them look greater than they are. In addition, 43.8 of psoriasis patients achieved completely clear skin at year 1 and this rate (43.5) was maintained to year 4.These patients are known to suffer greater disability and discomfort than those with psoriasis on other areas, Novartis said. The new warnings apply to Novartis AGs drug Elidel and Astellas Pharmas Protopic. Skin rash cause A skin rash refers to skin redness or inflammation.Going from clear skin to getting this at the same time or close to menopause and all its adverse symptoms has seriously effected my self esteem and Clear Skin Willow Bark Booster-Serum (0.5 oz / 15 ml bottle). One classic cosmetic bag in woven faux leather with bamboo zipper. Winner of Best Skincare Product for Acne, Beauty Shortlist Awards, UK, 2017 - Clear Skin Starter Set. Feel confident in your own skin with Alpha-H Clear Skin Blemish Control Gel. Enriched with natural anti-bacterial agents, skin is left clear of annoying blemishes, calm and soothed.Applies to most delivery addresses within mainland UK. Its time to ask your dermatologist for clear skin.What Its Like Living with Psoriasis, in GIFs. Im More Than My Skin, and Ill Show You. Why Hitting The Snooze Button Feels Good, Especially When You Have Psoriasis. Novartis International AG is based in Basel, Switzerland. It employs 119,000 people. GlaxoSmithKline PLC is based in London, UK.Together, we will create the worlds premier OTC business with clear opportunities to accelerate revenue growth.
recommended posts
- minecraft zombie apocalypse mod 1.7 10 forge
- harga baru xiaomi mi4w
- top neo geo fighting games
- vba excel check if a workbook is open
- hp officejet 4500 wireless driver download windows 10
- watch world live tv channels free
- watch hunter x hunter episode 45 english sub
- filme hd online gratis subtitrate in romana comedie
- gta 5 ps3 cheat lamborghini


text:
ABSTRACT: Gemcitabine (Gemzar) is a novel deoxycitidine drug that has demonstrated promising single-agent activity in non–small-cell lung cancer and has been proven to be a potent radiosensitizer. Although the exact mechanism of the radiosensitizing effect is unknown, several studies have focused on the drug's effect on deoxyadenosine triphosphate (dATP) pool depletion or cell-cycle manipulation. A number of trials have evaluated this feature of gemcitabine by combining chemotherapy and radiation in various doses and schedules, and those studies are described in this article. Gemcitabine appears to be a promising agent to be combined with radiation therapy. However, further clinical trials are needed to define optimal doses, toxicity, and efficacy. [ONCOLOGY 14(Suppl 4):20-25, 2000]
Recent research in lung cancer therapy has focused on combining radiation with chemotherapy in an attempt to improve patient outcome by controlling the tumor systemically with drug therapy while simultaneously attacking it locally with radiation. This approach is supported further by the now-established concept of radiation enhancement, whereby chemical agents have been shown to enhance the antitumor efficacy of radiation.[1,2] Several classes of drugs have demonstrated in vitro radiation enhancement activity; they include the taxanes, platinum analogs, topoisomerase inhibitors, and gemcitabine (Gemzar).[1-3] This newer approach to anticancer therapy offers hope of improved response rates and survival for patients with a variety of solid tumors, including lung cancer.
Gemcitabine is a novel deoxycitidine analog. It is particularly promising in combined chemoradiation regimens due to its efficacy in a wide range of solid tumors and its desirable safety profile.[4-10] Gemcitabine also has documented radiation-sensitizing capabilities, as established in vitro and in clinical studies.[11] It is approved for use in combination with cisplatin (Platinol) for the first-line treatment of patients with inoperable, locally advanced stage IIIA or IIIB, or metastatic stage IV non–small-cell lung cancer (NSCLC). This article will discuss preclinical studies investigating the mechanisms of gemcitabine's radiation-sensitizing capabilities and preclinical and clinical trials designed to quantify and establish the safety and efficacy of gemcitabine plus radiation in the treatment of non–small-cell lung cancer. It will then consider the new and exciting directions into which gemcitabine research may lead.
Mechanism of Action
The mechanism by which gemcitabine sensitizes cells to radiation therapy is not well understood. The radiosensitizing activity of gemcitabine has been examined in a variety of human tumor cell lines. Shewach et al first proposed a mechanism of action based on their study of HT-29 human colon carcinoma cells during exposure to the combination of gemcitabine and radiation. They found gemcitabine to be a potent radiosensitizer, even when delivered at noncytotoxic doses over a long period. On biochemical and metabolic analyses, they consistently observed rapid depletion of cellular pools of deoxyadenosine triphosphate (dATP), independent of measures of the other nucleotides, deoxyguanosine triphosphate (dGTP) and deoxycitidine triphosphate (dCTP).[12,13] They also noted that the cytotoxicity of gemcitabine may be related to the effect of its metabolite, gemcitabine triphosphate, on DNA replication.[14]
Gemcitabine triphosphate has been identified as both an inhibitor and a substrate of DNA synthesis—two actions that are documented features of other antimetabolites with proven radiosensitizing potential. Subsequent research from the same group uncovered similar dATP pool depletion in pancreatic, colorectal, and other solid tumor cell lines, with an equivalent advantage incurred with radiation therapy.[11,15] Thus, the researchers concluded that dATP pool depletion contributes to improved response to radiation therapy in the presence of gemcitabine.
Additional research has yielded other proposed mechanisms for gemcitabine's radiation-enhancing activity. Lawrence and colleagues observed that maximum radiosensitization occurs when gemcitabine-induced nucleotide pool depletion is accompanied by cell-cycle redistribution into the S-phase. [11,16] Milas et al have suggested a mechanism whereby gemcitabine eliminates radioresistant S-phase cells while synchronizing the rest of the tumor-cell population into a more radiosensitive phase of the cell cycle.[17] Furthermore, there is some evidence that gemcitabine may alter the threshold for cellular apoptosis in response to radiation.[18] As research continues, the relative impact of each of these potential mechanisms on gemcitabine's radiosensitizing efficacy should become clear.
Radiation Enhancement
In 1994, Shewach and colleagues described the results of a study in which they exposed HT-29 human colon carcinoma cells to noncytotoxic concentrations (10 nmol/L) of gemictabine prior to radiation therapy. They found that gemcitabine was a potent radiosensitizer in this setting (radiation enhancement ratio, 1.8), with maximum effect achieved if cells were irradiated immediately after having been exposed to drug for 16 to 24 hours.[12] Radiation sensitization occurred in a dose- and time-dependent fashion.
Subsequent studies evaluated the cytotoxic efficacy of gemcitabine plus radiation in HT-29 cells using higher doses of drug (0.1 µmol/L and 3 µmol/L) but at a reduced exposure (2 hours).[16] This attempt to better reproduce clinically relevant gemcita-bine concentrations revealed that sensitization is apparent at 4 hours after treatment and is sustained for up to 2 days: At 24 and 48 hours after exposure, the enhancement ratio for 0.1 µmol/L of gemcitabine was 1.8 and 1.4, respectively; that of the 3-µmol/L dose was 3.0 and 1.4, respectively. By 72 hours, the effect had disappeared.
Gemcitabine also was tested in SW-620 human colon cancer cells[16] and Panc-1 and BxPC-3 human pancreatic cell lines,[18] and again exhibited radiosensitization activity at noncytotoxic levels of drug. Furthermore, Zhang and colleagues exposed human breast cancer cells (MDA-MB 231 cell lines) to 24 hours of 10- to 20-nM gemcitabine prior to radiation. At these mildly cytotoxic concentrations, an enhancement ratio of 1.47 to 1.58 was recorded, and at 1-hour exposure to higher 1- to 2- µmol/L doses, the enhancement ratio was 1.45–1.54.[19]
Potent Radiosensitizing Agent
In summary, gemcitabine has been found to be a potent radiosensitizing agent. Several possible mechanisms for gemcitabine's radiosensitizing activity have been discovered in preclinical studies (Figure 1), including dNTP pool perturbation, cell-cycle redistribution, and reduction of the apoptotic threshold for radiation. In fact, all three of these factors may play a role in gemcitabine's influence on radiation, in which case DNA damage caused by radiation cannot be properly repaired, resulting in increased cell death through induction of apoptosis.
The average enhancement ratio of gemcitabine is ³ 1.5 and sensitization persists for at least 72 hours. These theories and others will be further investigated as basic research into gemcitabine activity continues, and the extensive documentation of the improved sensitivity of human cancer cell lines to radiotherapy after exposure to gemcitabine will be substantiated in clinical trials.
Approach to the Study of Combination Chemoradiotherapy
Given the predominant role of radiation therapy and the proven activity of gemcitabine in the management of lung cancer, mixing gemcitabine-based chemotherapy with a radiation regimen is a rational concept that can be expected to improve outcome related to the benefits of both modalities. Yet, because the combined impact of the two modalities may produce excessive toxicities, it is important to carefully select regimens of both radiation and chemotherapy so as to control the therapeutic ratio of radiotherapy both in tumor and normal tissue, without a parallel increase in treatment morbidity. Although there has been limited clinical experience published to date with chemoradiotherapy using gemcitabine, the available data will be reviewed in this article.
The combination of gemcitabine-based chemotherapy plus radiation needs to be evaluated from several perspectives, as follows:
(1) What is the benefit/risk of adding radiotherapy to a chemotherapy regimen?
(2) With radiotherapy as the base for local tumor control, does chemotherapy with gemcitabine proffer benefit?
(3) Is it safe and effective to give gemcitabine and radiotherapy concurrently?
In the first case, research would focus on a strategy for maximizing the impact of systemic drug therapy and then would assess the additive value of supplementing with irradiation. For instance, a phase I study would compare a maximum dose of gemcitabine with escalating doses of radiation to determine the appropriate dose of radiation in view of radiotherapy-driven toxicities. A phase II trial of the same comparison would follow to assess the supplemental effect on local tumor control when radiotherapy is added. Conversely, a trial designed to optimize local control with radiotherapy would use escalating doses of gemcitabine with a high radiation volume to isolate the maximum tolerated dose and then compare outcome in the radiation alone and radiation plus chemotherapy groups. Studies of each of these scenarios have been carried out.
1. Levine M: The action of colchicine on cell division in human
cancer animal, and plant tissue. Ann NY Acad Sci 51:1365-1408, 1951.
2. Skipper HG, Chapman JB, Bell M: The antileukemic action of
combinations of certain known antileukemic agents. Cancer Res
11:109-111, 1951.
3. DeVita VT, Hellman S, Rosenberg SA, (eds): Cancer: Principles &
Practice of Oncology, 5th ed. Philadelphia, Lippincott-Raven, 1997.
4. Carmichael J, Possinger K, Phillip P, et al: Advanced breast
cancer: A phase II trial with gemicitabine. J Clin Oncol
13:2731-2736, 1995.
5. Shapiro JD, Milward MJ, Rischin D, et al: Activity of gemcitabine
in patients with advanced ovarian cancer: Responses seen following
platinum and paclitaxel. Gynecol Oncol 63:89-93, 1996.
6. Lund B, Hansen O, Theilade K, et al: Phase II study of gemcitabine
(2´,2´-difluorodeoxycytidine) in previously treated ovarian
cancer patients. J Natl Cancer Inst 86:1530-1533, 1994.
7. Perng R-P, Chen Y-M, Jing-Liu J, et al: Gemcitabine vs the
combination of cisplatin and etoposide in patients with inoperable
non–small-cell lung cancer in a phase II randomized study. J
Clin Oncol 15:2097-2102, 1997.
8. Manegold C, Berman B, Chemaissani A, et al: Single-agent
gemcitabine vs cisplatin-etoposide: Early results of a randomized
phase II study in locally advanced or metastatic non–small-cell
lung cancer. Ann Oncol 8:525-529, 1997.
9. Rothenberg ML, Moore MJ, Cripps MC, et al: A phase II trial of
gemcitabine in patients with 5-FU-refractory pancreas cancer. Ann
Oncol 7:347-353, 1996.
10. Burris HA, Moore MJ, Andersen J, et al: Improvements in survival
and clinical benefit with gemcitabine as first-line therapy for
patients with advanced pancreas cancer: A randomized trial. J Clin
Oncol 15:2403-2413, 1997.
11. Lawrence TS, Eisbruch A, McGinn CJ, et al: Radiosensitization by
gemcitabine. Oncology 13 (10 suppl 5):55-60, 1999.
12. Shewach DS, Hahn TM, Chang E, et al: Metabolism of
2´,2´-difluoro-2´-deoxycitidine and radiation
sensitization of human colon carcinoma cells. Cancer Res
54:3218-3223, 1994.
13. Shewach DS, Lawrence TS: Radiosensitization of human tumor cells
by gemcitabine in vitro. Semin Oncol 22(suppl 11):68-71, 1995.
14. Shewach DS, Lawrence TS: Gemcitabine and radiosensitization in
human tumor cells. Invest New Drugs 14(3):257-263, 1996.
15. Shewach DS, Lawrence TS: Radiosensitization of human solid tumor
cell lines with gemcitabine. Semin Oncol 23(5 suppl 10):65-71, 1996.
16. Lawrence TS, Eisbruch A, Shewach DS: Gemcitabine-mediated
radiosensitization. Semin Oncol 24(2 suppl 7):S7-24–S7-28, 1997.
17. Milas L, Fujii T, Hunter N, et al: Enhancement of tumor
radioresponse in vivo by gemcitabine. Cancer Res 59(1):107-114, 1999.
18. Lawrence TS, Chang EY, Hahn TM, et al: Radiosensitization of
pancreatic cancer cells by 2´,2´-difluoro-2´-deoxycytidine.
Int J Radiat Oncol Biol Phys 34:867-872, 1996.
19. Zhang XL, Yang SL, Ashamalla H, et al: Gemcitabine-induced
radiosensitization of human breast cancer cells (abstract 1732). Proc
Am Soc Clin Oncol 17:449a, 1998.
20. Goor C, Scalliet P, Van Meerbeek J, et al: A phase II study
combining gemcitabine with radiotherapy in stage III NSCLC (abstract
481). Ann Oncol 7:101, 1996.
21. Data on file, Eli Lilly and Company, Indianapolis.
22. Gonzalez E, Sanchez-Rovira P, Jaen A, et al: Phase I study of
concomitant gemcitabine with radiotherapy in stage III NSCLC. Eur J
Cancer 35(suppl 4):A1054, 1999.
23. Groen HJM, Gregor A, van Putten JWG, et al: Phase I study of
gemcitabine (G) and high-dose thoracic radiation (RT) in stage III
non–small-cell lung cancer (NSCLC) (abstract). Proc Am Soc Clin
Oncol 19:2123a, 2000.
24. Blackstock AW, Richards FR, Lovelace JR, et al: Twice-weekly
gemcitabine and concurrent thoracic radiotherapy—A phase I/II
study in patients with advanced non–small-cell lung cancer
(abstract 1918). Proc Am Soc Clin Oncol 18:497a, 1999.
25. Zinner R, Fossella FV, Komaki R, et al: Phase I trial of
concurrent gemcitabine (G) plus chest radiotherapy (XRT) followed by
consolidation systemic chemotherapy with G plus cisplatin (CDDP) for
patients with stage III and medically inoperable stage II
non–small-cell lung cancer (abstract 1798). Proc Am Soc Clin
Oncol 18:466a, 1999.
26. Goss G, Lochrin C, Perry G, et al: A phase I study of gemcitabine
and cisplatin with concurrent curative irradiation in stage III
non–small-cell lung cancer (NSCLC) (abstract 1986). Proc Am Soc
Clin Oncol 18:515a, 1999.
27. Vokes EE, Leopold KA, Herndon JE, et al: A randomized phase II
study of gemcitabine or paclitaxel or vinorelbine with cisplatin as
induction chemotherapy and concomitant chemoradiotherapy for
unresectable stage III non–small-cell lung cancer (CALGB study
9431) (abstract 1771). Proc Am Soc Clin Oncol 18:459a, 1999.


text:
Is he screeching like a burnt cat because Mosdois HaTorah in New York took millions of dollars in federal funds to have their buildings wired for the internet?
Was he screaming like a lunatic because Rabbonim are molesting children?
Was he crying bitter tears because Jews are being murdered in the streets of Yerushalyim?
Nope! Guess again?
Give up?
Ok take a seat and a deep breath!
He was yelling and screeching because Frum Jewish Children are finally doing the right thing and joining the IDF to protect their family, their country and protecting Rabbi Samuels from getting his head chopped off by ISIS!
I am telling you ... these guys are going off the deep end!
I'm surprised that no one called the guys in white to put him into a straight jacket to ship him off to the funny farm!
And what is the biggest surprise is, that people are all sitting or standing listening to this maniac with straight faces!
Someone with guts should have taken a pie and smashed his face with it ... it would have been a Kiddush Hashem!