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Skin Care and Diseases |
Help!04/25/2007 |
Hello, I am a 19 year old female and ever since I can remember I have had very cold and horridly discolored dark purple hands. It doesn't hurt at all and I never experience any tingling. My feet and legs change to the same color, most of the time after I get out of the shower. I have been to the doctor several times and his response was just to change my diet in which I have.My hands change to a darker color in colder temperatures, especially in the wintertime. If I ever attempt to warm them up by running them under warm water, they turn bright red and eventually only after a couple minutes they're like ice again. Most of the time while I'm at work I have to cover them up with my sleeves or shove them in my pockets.
Will I have to be diagnosed with something that my doctor couldn't detect before or can I start taking any medication to make it stop?
It appears from you description that you have a condition called acrocyanosis. It is a condition involving abnormalities in how your blood vessels in your arms or legs (hands and feet) respond to temperature (usually turning purple in colder temperatures). It is not known what causes it although there are some links to thin women of fair skinned descent. In the majority of cases this is a harmless condition that has mostly a cosmetic and psychological impact. Keeping the extremities warm reduces the purple blue color changes. Some women outgrow this condition. There are no good treatments for it other than keeping it warm, eating a healthy balanced diet, and exercising.Rarely the condition can be related to eating disorders (such as anorexia) and medications. Given that there are a few conditions that can sometimes be confused with this condition (such as Raynaud's phenomenon), I would recommend that you see a board certified dermatologist for an evaluation to make sure nothing else is going on.
Pranav Sheth, MD Formerly: College of Medicine University of Cincinnati |


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After teasing fans of USA Network show "Psych" for several years with the idea of a musical episode, series creator Steve Franks finally confirmed it was happening — with a twist.
"We have partially written the musical episode … as a two-hour musical movie," said creator Steve Franks during the "Psych" panel at Comic-Con.
Also announced for "Psych" at the panel was a guest appearance of Jeffrey Tambor, who will appear on the show as the stepfather of Julia (played by Maggie Lawson).
As the first TV panel of the day in Ballroom 20, the fans of the USA Network packed the 2,000-plus-seat theater to maximum capacity. "Psych" star Tim Omundson led the Q&A panel.
USA programming chief Jeff Wachtel, the show's "benevolent god," hinted at a season eight, but would not confirm.
Above: Maggie Lawson reacts at today's "Psych" Comic-Con panel. (Alexandra Wyman/Getty Images Entertainment)

subset: commoncrawl


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Zambia has limited options to consider in its struggle for a better deal within the global capitalist system, observes Jeyakumar Devaraj.
Zambia has limited options to consider in its struggle for a better deal within the global capitalist system, observes Jeyakumar Devaraj.
Even if Malaysia's GDP is growing, the wages of the majority of its people are trapped in the low-income range, points out Low Swee Heong.
Low wages and economic policies that are not in the interest of the ordinary people are driving households deeper into debt, observes Anil Netto.
Burma's poorly paid garment workers are anticipating a pay hike this year, report Thida Win and Yadana Oo. But this has to be put in perspective: 1,000 Kyat is equivalent to about US$1, so the pay rise is only about $10.
At a time when the Human Resource Minister talks about workers earning poverty wages of less than RM720 a month, S Arutchelvan expresses dismay over an Industrial Court award that glorifies the plantation employers' proposal of what it calls a 'safety net' of RM450.
If children cannot be protected against an exploitative and unjust system, what is the rationale for standing in their way when they participate in actions to demand their rights, asks Rani Rasiah.
Should not the the Prime Minister change his government policies to meet the needs of the rakyat instead of forcing the rakyat to change to meet his policy needs, asks Rani Rasiah in an open letter to the premier.
Workers in Malaysia can only have a brighter future if they seek to organise and mobilise themselves to effect political changes that are favourable to them, observes Toh Kin Woon.
Rani Rasiah takes up the theme by looking at the hypocrisy of the 'people first' slogan in a system which squeezes low-income workers on all fronts. Low wages without proper retrenchment compensation only results in poverty, she asserts.
The Asian Migrants Centre, the MAP Foundation and the Workers and Farmers Solidarity League of Burma applaud the brave action taken by workers in industrial zones in Burma who have protested against exploitative working conditions despite the threat of a crackdown.
Photo courtesy of Irrawaddy
Imagine being paid RM1 per hour and yet being expected to lay down your life in the line of duty. J John writes about the plight of underpaid security guards who have to work long hours to earn a subsistence wage.


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Home › Forums › Gear Forums › Gear (General) › I have GOT to get a new tent.
May 15, 2010 at 3:39 pm #1258990
Just adding up the weights before we go on a 27 mile loop hike in a couple of weeks. I've changed some things from our previous trip. I was carrying roughly 25+ pounds (my first time out, actually) and the wife was carrying a little less than 20.
Well, even with 4 days worth of breakfast and dinner (haven't gotten lunch figured out/weighed yet) she's down to 15 pounds. I could join her there if our tent didn't weigh 7 lbs. (I carry the tent) It's a beautiful, roomy Nemo Losi 3P, but it's more akin to car/base camping than backpacking. We could split up the weights, but my legs do have a bit more muscle than hers (cycling).
I've got my eye on the Haven tarp + net tent combo.
But I am at 20 lbs., so it isn't all bad. She's only carrying a little over a pound of equipment that I would need if I went solo.
If I were working with the SMD Haven tent and on a solo trip, I'd be at 16 pounds before food. Sounds like a nice enough goal.
May 15, 2010 at 6:35 pm #1610157I haven't seen a Haven in person, but we own a Lunar Duo from the same company and it's just a great tent for two people. Fully loaded with six stakes and a stuff sack it's 45 ounces. The interior size has to be seen to be believed, and it has two doors and two big vestibules.
The first backpacking trip we took, a four day hike in Virginia in very pleasant late-May weather about 15 years ago, I carried 65 pounds and my lovely wife carried 45. I would say your first trip was pretty light in comparison to most every hiker I know.
But, yeah, at seven pounds you need a lighter tent.
May 15, 2010 at 7:40 pm #1610164To be fair, Nemo's site says 6.5 pounds packed (stuff stack, stakes, etc.) and the scale I use is a digital bathroom scale that is crappy at lower weights. So I did the stand on the scale then stand on the scale while holding trick and got 6.5 pounds.
Still, need a lighter tent.
May 15, 2010 at 7:47 pm #1610168Jonathan,
You might consider taking a look at some of the Tarptents over at tarptent.com. The Double Rainbow and Cloudburst are both excellent 2 person tents at 2# 8 oz and 2# 6 oz, respectively. The only downside is that they are single walled and, therefore, prone to condensation in high humidity areas. Tarptent also makes a double wall tent, the Scarp 2, which would perform much better in humid conditions. It weighs 3# 4 oz.
May 16, 2010 at 5:34 am #1610240JUST POSTED: on 05/16/2010 06:06:37 MDT
Black Diamond HiLight Tent with Vestibule – "1ST Generation"
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Please contact me at email@example.com 16, 2010 at 7:38 am #1610259> I've got my eye on the Haven tarp + net tent combo.
Hi Jonathan,
I just got my Haven tarp and net combo last week.
It is very nice. Dead on the advertised weights.
It goes up quick. Loads of room for two. Two side doors
and two vestibules that are not as large as Lunar duo,
but plenty big for a pack and your boots.For me the big pluses are:
– I backpack in places with high humidity so the double wall really helps manage condensation. I am always having to wipe down the inside of my single wall tents.
– Being two pieces, I can just carry the tarp going solo if I want to go lighter.
– Great views and breeze with both sides of the tarp open.May 16, 2010 at 8:00 pm #1610465I hear you on that one. I camp primarily in the south (oklahoma/arkansas area) so humidity is a big issue.
No offense to Tarptents, but it gets real old real fast when a poster asks for a lightweight 2 person tent and even after specifically mentioning they would like a double wall, seven people here chime in with a link to tarptents and the assurance that "condensation isn't really that big of a deal."
That's why I'm really digging the Haven combo. Satisfies both needs in a great package.
Sorry is this post sounds hostile, but I can almost clock the amount of time it takes a tent thread here to turn to tarptents. They are indeed great products, but they don't work for everyone.
May 16, 2010 at 8:07 pm #1610469I've got myself down to 17.7 pounds "pack weight", 20 pounds total with poles and clothes on my body (and a knife I carry in my pocket).
She's down to 16 pounds "pack weight" with about 4 pounds of food and these 1 pound 3 oz. sandals she insists on bringing instead of flip flops. And 17 pounds total with poles and clothes on her body. So her pack weight will be down to a sleek 12 pounds at the end of the trip.
This is for a 4 day trip to Eagle Rock Loop in Arkansas.
And actually, I just realized I don't have our shoes listed in those weights. Maybe a pound a pair? They are Merrel trail runner type shoes. And of course we'll have about a liter or so in our hydration packs as well. So I guess add a few pounds to each of those weights
I think we're doing alright for such a huge tent thrown into the mix. If I can save some scratch for the Haven, we can split things up a bit more and start getting seriously light weight.
May 17, 2010 at 2:46 am #1610510"No offense to Tarptents, but it gets real old real fast when a poster asks for a lightweight 2 person tent and even after specifically mentioning they would like a double wall"
Sorry, I didn't notice where you said that in your original post. I will retract my suggestion of the Lunar Duo.
May 17, 2010 at 8:46 am #1610550Well, to be honest, I didn't really mention it in this thread. But I do see it often where a poster asks for a lightweight doublewall option and everyone goes straight to tarptents.
I mean, honestly, if I could get away with it, I would. Tarptents are great products and a great option if it meets your needs. That's why it's such a popular suggestion.
If anything, this is more of a standard internet thing. Lots of people (including myself) might give a suggestion without reading the original post thoroughly. It happens.
May 17, 2010 at 8:49 am #1610555Just remember that Henry Shires does sell a double wall – the Scarp 2, that Tom Kirchner mentions above. I think he also sells a liner for the Rainbow to aid with condensation. Don't know how good it works, perhaps others do.
May 17, 2010 at 4:37 pm #1610728"If anything, this is more of a standard internet thing. Lots of people (including myself) might give a suggestion without reading the original post thoroughly. It happens."
It just happened to you. IF you had read my entire post you would have noticed that I inquired as to whether humidity was an issue and, if it was, perhaps take a look at the SCARP 2 which IS double wall. I just went back and read your original post, which is vague to the point of inviting recommendations for just about any type of tent.
If you're going to ask for suggestions here, accept them in good grace and act on them as you will. Otherwise ask elsewhere and stop wasting helpful people's time as far as I'm concerned.
You must be logged in to reply to this topic.


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If sake is unavailable, substitute dry vermouth. Miso paste tastes surprisingly good with butter. The red variety has a more pungent flavor than yellow or white miso and is a terrific match for meat.
Leave a Review
Amazing! Will never pay for hibachi again after making this! Made it with Filet, as it was made for Valentine's Day. Also doubled the miso butter and sake recipe so we could have extra sauce. Hands down - DIVINE! My husband and I both looked at each other and melted on the firsts bite! Also, we seared the filets in the skillet, but cooked them at 425 in the oven so as to keep them tender! Wonderful recipe!!!!
This was pretty tasty, the sauce was nice but something something in the tastes was a bit off. In the future I will try other recipes that marinate the steak with miso or have a simpler sauce. I think what bothered me about this might have been that I only wanted the tastes of steak and miso.
I made this for my husband for Father's Day recently, and he is still raving about it weeks later. I made the recipe exactly as written, with the exception of slicing the steak at the end. I also made a tofu version for myself and our toddler, and it was a big hit with us too. DH declared the sauce better than his beloved Worcestershire sauce - which is a pretty big deal since he prefers it over just about everything else for steak.
Quick and delicious. I almost skipped the green onions, figuring who needs green onions, but they are key. I will make this again, maybe tri tip next time.
We really liked this a lot, especially given how quickly it came together. Served it with steamed veggies and rice. This will definitely make it into our weeknight rotation.
this came out quite tasty. Couldn't find red miso near me so I bought a red miso soup packet and just sifted out the extras and it came out great.
while this was quite easy, and tasty enough, the flavour combination sounded a lot more promising than the final result, which was kind of dull and uninspired. I have made far better miso sauces following recipes from Elizabeth Andoh, this one is quite unremarkable -- and I was underwhelmed with the dish.
Quick, easy, and very flavorful! I've made this three times now on my boyfriend's request - twice with flank steak and once with chicken. Used crushed cumin for the crust and made the sauce exactly as instructed. It's come out beautifully every time. Served with plain basmati rice which worked well because the miso is strong and salty.


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Language School La Rochelle — Eurocentres: A journey through space and time
Perfect your French in a place where others holiday during a language study stay at the school in La Rochelle. The west coast of France offers a beautiful backdrop and the language school in La Rochelle is an architectural experience in itself. The school is housed in a futuristic building that was designed especially for this purpose. The fantastic location, the skilled language tuition, two huge sun terraces, spacious and bright rooms and a multitude of attractive recreational activities all make a language holiday in La Rochelle particularly popular. La Rochelle is multi-faceted and is in the third most popular tourist region in France. Cliffs, bays, fishing villages, harbour scenes – you will find maritime life at its best here. Culture and history are all around you.
Feel the Atlantic breeze in your hair at the language school in La Rochelle – it lies directly next to the beach, yacht harbour and city centre. The historic centre of La Rochelle is an exciting open-air museum: The ancient harbour, Middle Ages towers and artistic old buildings turn a city tour into a journey through time. There are also countless recreational opportunities close to the school: Cafés, terraces, bars, restaurants, water sports, bike tours, film, music and theatre events. The host families are often retired people: They welcome you into their homes with open hearts and a sympathetic ear. They often keep in touch with students for many years afterwards. Maybe you will soon be biking your way through this interesting city on France's west coast.
What our clients say – find out what our students appreciate most about our schools. Click here for testimonials!
School Services
- Cafeteria
- Computer room
- Kitchen
- Learning centre
- Library
- Piano
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- Wifi
A typical day at Eurocentres La Rochelle
Rooms flooded with sunlight, the smell of sun cream, the sound of cafeteria chatter... Impressions from La Rochelle. Mirjam from Germany is here to perfect her French. She chose La Rochelle because she loves the ocean and likes a wide variety of recreational activities. It was the best decision! The sympathetic ambience and the well-structured language tuition are just what she was hoping for. Her friend from the USA also comes on to the sun terrace, where they discuss together – in French – what they want to do after school. Students come here from all corners of the world, which ensures an interesting multicultural mix.
Many students hire a bike in order to travel from their accommodation to the school or to tour the beautiful coastal area. You can learn to sail on the Atlantic or just go swimming, but there is also lots to do away from the water. There is even a piano at the school for the students to play – which Mirjam is particularly pleased about. She sometimes organises a concert with her fellow students. The teachers take time for each of the individual students – with a maximum of 14 students per class, this is easily possible. Thanks to this, Mirjam has been able to considerably improve her language skills. With the regular coaching, she is making fast, targeted progress. La Rochelle – she will miss it!
Virtual Tour
Facts and Numbers
Student Nationalities
Western Europe | 80% | |
Eastern Europe | 2% | |
Asia | 3% | |
Latin America | 14% | |
Various | 1% |
Age Mix
Ages 16-18 | 29% | |
Ages 19-24 | 45% | |
Ages 25-30 | 15% | |
Over 30 | 11% |
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School Holidays


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Governmentwide Acquisition Contracts
Governmentwide Acquisition Contract Dashboards
The GWAC program has taken its data to the next level by creating an interactive tool that allows GWAC stakeholders to view and segment GWAC information to make better business decisions.
You have the ability to:
- Explore GWAC data by contract family, federal agency, and industry partner.
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The shortcut to this page is www.gsa.gov/gwacdashboards.
The GWAC Dashboard is compatible with Internet Explorer 8 and 9 using Flash Player 14.4.X. If you are using any other version, you may experience usability issues.


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Conn's Inc. (CONN) was one of the Russell 2000's biggest losers for Wednesday January 06 as the stock slid 6.5% to $19.43, a loss of $-1.35 per share. Starting at an opening price of $20.29 a share, the stock traded between $19.21 and $20.72 over the course of the trading day. Volume was 998,108 shares over 4,988 trades, against an average daily volume of 864,612 shares and a total float of 32.24 million.
The losses send Conn's Inc. down to a market cap of $626.52 million. In the last year, Conn's Inc. has traded between $43.95 and $14.98, and its 50-day SMA is currently $23.75 and 200-day SMA is $30.57.
The stock has a P/E Ratio of 16.9.
Conn's Inc is a specialty retailer of branded durable consumer goods offering products such as furniture and mattresses, home appliances, consumer electronics and home office products. It also provides consumer credit to support its customers' purchases.
Conn's Inc. is based out of The Woodlands, TX and has some 4,300 employees. Its CEO is Norman Miller.
For a complete fundamental analysis analysis of Conn's Inc., check out Equities.com's Stock Valuation Analysis report for CONN. To see the latest independent stock recommendations from Equities.com's analysts, visit our Research section.
The Russell 2000 is one of the leading indices tracking small-cap companies in the United States. It's maintained by Russell Investments, an industry leader in creating and maintaining indices, and consists of the smallest 2000 stocks from the broader Russell 3000 index.
Russell's indices differ from traditional indices like the Dow Jones Industrial Average (DJIA) or S&P 500, whose members are selected by committee, because they base membership entirely on an objective, rules based methodology. The 3,000 largest companies by market cap make up the Russell 3000, with the 2,000 smaller companies making up the Russell 2000. It's a simple approach that gives a broad, unbiased look at the small-cap market as a whole.
For more news on the financial markets, go to Equities.com. Also, learn more about our independent proprietary equity research reports and our robust do-it-yourself Stock Valuation Analysis reports in our Research section.
All data provided by QuoteMedia and was accurate as of 4:30PM ET.
DISCLOSURE: The views and opinions expressed in this article are those of the authors, and do not represent the views of equities.com. Readers should not consider statements made by the author as formal recommendations and should consult their financial advisor before making any investment decisions. To read our full disclosure, please go to: http://www.equities.com/disclaimer


text: No recent wiki edits to this page. History:The Virage enemies are a group of unusual, gargantuan creatures featured heavily in The Legend of Dragoon. Historically, they were the 108th Fruit from the Divine Tree. They were the species of choice for the Winglie race back in the days of the Dragon Campaign, when Winglies ruled over Humans. During said campaign, the Humans battled the Winglies and their Virage army, ultimately succeeding and virtually eliminating all traces of the Virage species from the planet. It isn't until the events of the game that you start coming across dormant Virage enemies, who then awaken to battle you. A major plot point revolves around the mystical Virage Embryo, quaintly referred to throughout the game as the God of Destruction, whose purpose upon being born is to destroy all life on the planet. It is revealed that this powerful being is split into 2: its body, way up on the Moon That Never Sets, and its soul, lying dormant inside the fabled Moon Child. Every 108 years the Moon Child comes around, and the soul of the Virage Embryo attempts to reconnect with its body, and go through with its true purpose. Battles:All in all, you'll fight 4 different Virage bosses: Virage (Head, Body, Arm) HP: Head - 350; Body - 400; Arm - 50 Drop: Healing Potion x2, Mind Purifier, 100G EXP: 600First start off by eliminating the really weak Arm. It will regenerate occassionally, but it's still an easy kill each time. The way to finish this battle is to kill both the Head and Body. Focus on the Head after the Arm as the Head deals out the most damage. Virage (Head, Body, Arms x2) HP: Head - 1,500; Body - 900; Arms - 350 Drop: Moon Serenade, 200G EXP: 4,500Like the first Virage boss battle, immediately take out the arms (they still regenerate, but you'll want to avoid their instant death attacks). Then focus on the Head, so you can try to avoid its status effect-inflicting attacks. Once the Body and Head are out of the picture, the battle is over. Super Virage (Head, Body, Arm) HP: Head - 10,000; Body - 10,000; Arm - 3,000 Drop: Healing Rain, 200G EXP: 4,000 This battle will end when you kill the Body and Head (again) or if you just wait until the Super Virage's 10 turn death counter ends. It has some pretty hefty attacks, but nothing that can't be healed easily. If you decide to wait out the 10 turn death counter, then be sure to use Rose Storm to protect your team right when the counter reasches its final turn (1 Life Remaining). Super Virage (Head, Body, Arm) HP: Head - 10,000; Body - 15,000; Arm - 3,000 Drop: 300GEXP: 15,000 This battle is much like the previous Super Virage battle, minus a 10 turn countdown. The foe is very slow and has poor Defensive stats, so some good, solid additions or D-Magic/D-additions will take this guy out fast. He has only one attack that should cause some concern, and that's its asteroid attack, which can dole out over 1,000 damage. Otherwise, take out the Body and Head and advance through the story.


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SRK's dance ka jalwa!
King Khan grooves while promoting his upcoming flick Chennai Express
Seven films of Shah Rukh Khan that complete 20 years! Check out the films here:
AbRam's adorable moments with SRK on his 2nd birthday! Have a look at his cute photos with his family
SRK's versatile looks over his 23 year long Bollywood journey Check out the different avatars of SRK over the years
SRK drops a bomb with the impressive Fan teaser! The movie will be released in April 2016
Shah Rukh Khan acts Shaana! The superstar enjoying on the sets of his new show
Shah Rukh at the grand launch of his new TV show 'India Poochega' The superstar was seen dancing for the audience
SRK spills his charisma yet again! The actor recently attended a launch event
Saina Nehwal gets her fan-girl moment with SRK in Hyderabad The badminton champ is a huge fan of the actor
Tag: srks dance ka jalwa, srk, shahrukh khan, chennai express, event, latest bollywood news, bollywood gossip, dance, bollywoo
By Team Biscoot | Aug 8,2013,04:58 PM IST | Views 1065
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Take a look at these best-dressed B-town beauties of the week These fashionistas have mesmerized us withe each appearances


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The Huainanzi : A Guide to the Theory and Practice of Government in Early Han China, by Liu An, King of Huainan
Free delivery worldwide
Dispatched from the UK in 1 business day
When will my order arrive?
Compiled by scholars at the court of Liu An, king of Huainan, in the second century B.C.E, The Huainanzi is a tightly organized, sophisticated articulation of Western Han philosophy and statecraft. Outlining "all that a modern monarch needs to know," the text emphasizes rigorous self-cultivation and mental discipline, brilliantly synthesizing for readers past and present the full spectrum of early Chinese thought. The Huainanzi locates the key to successful rule in a balance of broad knowledge, diligent application, and the penetrating wisdom of a sage. It is a unique and creative synthesis of Daoist classics, such as the Laozi and the Zhuangzi; works associated with the Confucian tradition, such as the Changes, the Odes, and the Documents; and a wide range of other foundational philosophical and literary texts from the Mozi to the Hanfeizi. The product of twelve years of scholarship, this remarkable translation preserves The Huainanzi's special rhetorical features, such as parallel prose and verse, and showcases a compositional technique that conveys the work's powerful philosophical appeal.
This path-breaking volume will have a transformative impact on the field of early Chinese intellectual history and will be of great interest to scholars and students alike.show more
Product details
- Hardback | 1016 pages
- 162.56 x 236.22 x 55.88mm | 1,292.73g
- 30 Apr 2010
- Columbia University Press
- New York, United States
- English
- 2 tables in the interior
- 0231142048
- 9780231142045
- 94,669
Review quote
An excellent and richly annotated translation. -- Moss Roberts Journal of the American Oriental Society Users of this magnificent contribution to the study of Chinese thought will find here almost everything imaginable. -- Russell Kirkland Religious Studies Review It is a major accomplishment in every sense of the term. -- Mark Csikszentmihalyi Journal of Chinese Studies In sum, this volume bringing to annotated translation all 21 chapters of the Huainanzi will invaluably ease and enhance the work of future scholars. -- Benjamin E. Wallacker Journal of Asian History [An] epochal achievement... The Huainanzi vibrates with the authors' intellectual confidence... this translation of the Huainanzi is a convenient and reassuring shortcut into the heart of traditional China. -- Barbara Hendrischke Monumenta Serica This English version earns for the Huainanzi the widespread recognition as anepochal classic that it deserves, and at the same time provides a resource forspecialists. The translations are carefully thought out but evocative. China Review Internationalshow more
About Liu An
John S. Major, formerly professor of history at Dartmouth College, is an independent scholar and writer. He is the author of Heaven and Earth in Early Han Thought: Chapters Three, Four, and Five of the Huainanzi and the author, coauthor, or editor of almost thirty other books, including Defining Chu: Image and Reality in Ancient China. Sarah A. Queen, professor of history at Connecticut College, is the author of From Chronicle to Canon: The Hermeneutics of the Spring and Autumn, According to Tung Chung-shu. Her current work includes a translation and study of the Luxuriant Gems of the Spring and Autumn (with John S. Major) and an edited volume, Liu An's Vision of Empire: New Perspectives on the Huainanzi (with Michael Puett). Andrew Seth Meyer, assistant professor of history at Brooklyn College, is the author of several articles, including "The Sunzi bingfa as History and Theory." His current projects are To Rule All Under Heaven, a history of the Warring States period (481-221 B.C.E.), and a translation of the Wenzi (with Harold D. Roth). Harold D. Roth, professor of religious studies and East Asian studies at Brown University, is the author or editor of four books and more than forty scholarly articles. His books include The Textual History of the Huai-nan tzu and Original Tao: Inward Training and the Foundations of Taoist Mysticism. Michael Puett, professor of Chinese history at Harvard University, is the author, most recently, of Ritual and Its Consequences: An Essay on the Limits of Sincerity. Judson Murray, assistant professor of religion at Wright State University, is the author of "A Study of 'Yaolue,' 'A Summary of the Essentials': Understanding the Huainanzi Through the Point of View of the Author of the Postface."show more
Table of contents
AcknowledgmentsIntroduction1. Originating in the Way2. Activating the Genuine3. Celestial Patterns4. Terrestrial Forms5. Seasonal Rules6. Surveying Obscurities7. Quintessential Spirit8. The Basic Warp9. The Ruler's Techniques10. Profound Precepts11. Integrating Customs12. Responses of the Way13. Boundless Discourses14. Sayings Explained15. An Overview of the Military16. and 17. A Mountain of Persuasions and A Forest of Persuasions18. Among Others19. Cultivating Effort20. The Exalted Lineage21. An Overview of the EssentialsAppendix A. Key Chinese Terms and Their TranslationsAppendix B. Categorical TermsAppendix C. A Concise Textual History of the Huainanzi and a Bibliography of Huainanzi StudiesIndexshow more


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EcoATM is placing kiosks around the United States that allow you to recycle your old tech and get a bit of cash in return. Will they be as popular as Redbox one day?
2012's first auto show will showcase the Craftsman CTX riding lawn mower with cupholders, traction control, and an iPod adapter.
Sony has been in a downward spiral ever since it missed the boat on the iPod revolution. What will it take for it to regain its former glory?
Automakers still have a litany of dog-ate-my-homework reasons of why it's so hard to find MP3 hooks in your car. Good news: We're almost at the tipping point for USB jacks.
Chevy builds a great subcompact, targets Millennials, then leaves iPod and Bluetooth off the standard-equipment list. Is this what our bailout dollars went towards?
Steve Jobs was a design genius — but the only reason we recognize that today is because he remained a tireless advocate for nearly two decades, despite numerous failures.
It's hard to put into words the legacy that Steve Jobs will leave behind… but we can put it into pictures.
With its new Tegra processor, Nvidia wants to bring power to all kinds of mobile computing—especially your car. Also: The evolution of 3D Vision.
Loyd Case struggles to find audiophile happiness with digital music. Getting the music from iPods, other music players and PCs is harder than it should be. Why can't everyone just get along?
No WMA Lossless!The Denon AVR-4306 is the most current receiver from Denon, but even it doesn't support WMA lossless.
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DRV-2 Uber Drivulator The Uberdriveulator is a much cleaner drive circuit with more headroom and can operate in two modes the Loose mode is similar to the tight mode of the Standard Overdrive but with a bit more headroom and the tight mode which has even more clean headroom and much more output power. The unit has a Drive control that can turn up the gain of the drive circuit 100 times. A very wide range and musical sounding tone control and a volume control to keep the gain under control, can be used as a clean boost. Also included is a trim pot to set the output gain. This unit is True Bypass using an ALCO heavy duty Footswitch.
©2004 - 2006 Global Vintage NEW | site by Konceive


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Too soon to judge day-labor site
The article, 'Day-labor site falls down on the job,' (July 24) about the new Portland day-labor center was both pre-emptively dismissive and irresponsibly reported.
It narrowly defines the success of the center by how many workers still wait on the corner. This is a vast oversimplification of what the center provides for the entire community.
The article makes no mention of the vast abuses workers risk when looking for work on the corner, such as physical harm and contractors who refuse to pay them at the day's end.
Nor does it acknowledge the benefits to contractors, who can come to the center looking for a particular type of skilled worker without having to negotiate the somewhat chaotic environment of the corner.
Furthermore, your article implicitly assumes that the center only benefits undocumented workers. The center provides all workers with safety and dignity, making it a space that invites documented workers who are struggling in a difficult economic time. Many of the workers at the center who have adequate documentation would not wait for work on the corner because of the risks involved.
The center has been open for only seven weeks. The corner has existed for years. Before you continue your irresponsible series on the center's failure, the Portland Tribune must challenge its pre-emptive assumption that the hire site will inevitably fail and fairly report how it is benefiting the community as well.
Kendall Taggart
Southeast Portland
Expand proposed toll to include more users
Tolls to cover the costs of road repair and improvement in Portland seems one-sided. If the true reason for instituting tolls is for improvement, why not toll all areas of access to these corridors, such as the south end of Interstate 205, the tunnels and south I-5, as well as the new improved intersections planned for I-5 in Portland?
This is a government that wants to look good to their voters and punish those who support the state by way of an income tax. The burden needs to be shared by all who travel on these roads.
Tom Boozer
Vancouver, Wash.
Substitute teachers integral part of staff
Regarding Chris Fick's opinion piece 'Improving teaching time' (Insight, June 26), I spent six years as a substitute teacher.
Most subs are called with about an hour's notice. Often the caller will say, 'I know this isn't your endorsement, but we just need someone to sit in the classroom.' Regardless of how prepared a sub is to teach, the school staff looks at you just as a baby sitter.
At one time there were private workshops for substitute teachers to help them prepare for a classroom without lesson plans, but the workshops were too expensive and could not be used toward your license renewal.
I was an archaeologist in my earlier years, so I developed two archaeology lesson plans, complete with hands-on activities and a worksheet that I turn in to the regular classroom teacher. I never introduced myself as a sub - always as an archaeologist. I would have the students work in groups of three or four. One lesson was a 30-minute unit, the other was a 10-minute unit.
This was how I kept from being eaten alive by bored students.
I do feel school districts could better serve their students if they developed alternative lesson plans relating to the curriculum being taught during any term.
If all the components necessary to teach the unit were included, substitute teachers could become a valuable part of a given school's staff and - most importantly - students' education wouldn't be as disrupted by their teacher's absence.
Rose Case


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Systematic absences
From Online Dictionary of Crystallography
Absences systématiques (Fr). Extinciones sistemáticas (Sp). Assenze sistematiche, estinzioni sistematiche (It). 消滅則 (Ja)
One speaks of systematic absences or extinctions when the structure factor is zero, due either to the centring of the lattice or to the presence of glide or screw symmetry elements. Conversely, the conditions for a reflection to exist and not to be systematically absent, are called reflection conditions.
See also
reflection conditions
Sections 2.2.13 and 12.3.5 of International Tables of Crystallography, Volume A


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Experts at the Johns Hopkins Center for a Livable Future (CLF), say that new Food and Drug Administration (FDA) voluntary guidelines on antibiotic use in food animal production are unlikely to reduce the widespread use of the drugs in food animals or address the public health crisis of increasing antibiotic resistance. Decades of scientific research, including studies led by CLF researchers, have linked the misuse of antibiotics in food animals to rising antibiotic resistance in human pathogens.
Guidance for Industry #213, the FDA document released today that outlines the new guidelines, asks drug companies to voluntarily withdraw approvals to use antibiotics in food animals for "growth promotion," while keeping approvals to use these drugs for "disease prevention." In both cases, antibiotics are fed to animals at low doses, often throughout their lives, making bacteria resistant to drugs used to treat infections.
"Problems can arise whenever antibiotics are fed to animals at low doses for long periods of time," says Keeve Nachman, PhD, MHS, a CLF scientist with the Johns Hopkins Bloomberg School of Public Health's departments of Environmental Health Sciences and Health Policy and Management. "Whether you call it growth promotion or disease prevention, this makes antibiotics less effective for treating sick people."
Many antibiotics are approved fr both growth promotion and disease prevention at similarly low doses and without limits on how long they may be used. This means that even if all growth promotion approvals were withdrawn voluntarily, many antibiotics could still be used in similar ways. Under the guidelines, drug companies and the food animal industry could label such use "disease prevention."
"The FDA may care whether companies call it growth promotion or disease prevention, but the bacteria do not," says Nachman. "If antibiotics are used in the same ways, they will have the same effects."
"The widespread misuse of antibiotics in food animal production reduces the effectiveness of drugs we heavily rely on to keep the public and our families safe," says Robert Lawrence, MD, director of CLF and a professor with the Bloomberg School's Department of Environmental Health Sciences. "An infection that is now considered relatively easy to treat could once again prove fatal should antibiotics continue to be misused in food animal production and exacerbate this growing public health crisis."
"The agency needs to change how antibiotics are used, but these guidelines will only change how they are labeled," adds Nachman. "Instead of issuing voluntary guidelines, the FDA should use its regulatory authority to protect public health by withdrawing all approvals to use antibiotics for disease prevention and growth promotion."
Source: Johns Hopkins Bloomberg School of Public Health


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Check Out Our New Blog – Weevil News!
Episode 5 of My Little Pony: Friendship is Magic Series 5 has landed!
Join Twilight Sparkle and the rest of the Pony pals over at Rigg's Movie Multiplex and watch the brand new episode now!
You can also play awesome games, download pony-tastic treats and ponify your nest with tons of cool new nest items! You could even win your own Cutie Mark Magic Castle and an unbelievable 10,000 Mulch in our My Little Pony competition.
The more you complete the more XP you'll earn with your very own Friendship Bar – see if you can get 100% before your friends!
Head there now and be sure to let us know what you think by leaving us a comment below.
BREAKING NEWS: Scribbles' New Project Revealed!
The What's New Blog that you know and love is getting a makeover! The Bin Weevils Team have been busily working on the update and we can't wait to share it with you! What a Bin-tastic way to kick-start the new year!
Spotted any cool new blog details on Scribbles' computer screen?
Join the discussion by leaving a comment below and stay tuned for more information next week!
Weevil of the Week – b1nbee!
Congratulations to b1nbee for being selected as our 67th Weevil of the Week!
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Their favourite Bin Weevils character is Snappy and their favourite colour is turquoise! What's more, b1nbee's favourite foods are Bin Salads, Chocolate Sludge Cakes and Slime Sandwiches – yum!
Additionally, you can see that b1nbee is a level 39 Bin Tycoon member with their very own Bin Pet!
b1nbee says, "I am a responsible Weevil and I try to make the Bin happier!"
Well done, b1nbee! hope you enjoy the next 7 days as a giant Big Weevil!
You could be the next Weevil Of The Week and win a super, fantastic, amazing prize pack too!
Bin Tycoon Sneak Peek – 2 American Diner Nest Item Codes!
Calling all Bin Tycoons!
Who remembers the upcoming American Diner nest items showcased on the January Highlights blog post earlier this week?
Well… the nest item set isn't quite ready to go on sale just yet, but we've decided to give all our Bin Tycoon members early access to two of the brand new items!
We hope Bin Tycoons across the Binscape will enjoy this exclusive sneak peek at the Classic American Diner Booth seating and the Classic American Diner Table!
All you have to do is log in and redeem these two codes at the Mystery Code Machine to get your items!
Both codes will remain active until 20th January 2016 and all Weevils will be able to buy plenty of American Diner style nest items at Nestco very soon!
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Sunday, Feb. 14 (DAY 3)
1-6 p.m. - Women's Speedskating-3000 Gold Medal Final (LIVE); Nordic Combined-Individual Gold Medal Final: K-90 Jumping (LIVE) and 10km Cross Country (LIVE); Men's Luge-Singles Competition (LIVE); Men?s Biathlon-10km Sprint Gold Medal Final (LIVE).
7-11 p.m. - Figure Skating-Pairs Short Program (LIVE); Men's Freestyle Skiing-Moguls Gold Medal Final (LIVE); Men's Luge-Singles, Gold Medal Final; Women's Alpine Skiing-Super Combined Gold Medal Final.
11:35 p.m.-12:05 a.m. - Figure Skating-Pairs Post Game; Medals Plaza-Award Ceremonies.
12:05-4:05 a.m. - Primetime Replay.
3-5:30 p.m. - Women's Ice Hockey-USA vs. China (LIVE).
7:30-10 p.m. - Women's Ice Hockey-Finland vs. Russia (LIVE).
3-5:30 a.m. - Women's Ice Hockey-USA vs. China (replay).


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I have scoured this Wal-Mart and that Wal-Mart...and even that Wal-Mart...and I can't find them anywhere. Are they out or did I miss them altogether? I got a BMF Falcon (seeing them everywhere), the B-Wing and some figs...however no A-Wings at all in sight. I thought they were coming out on July 26th? Nope...at least not at any of the Wal-Marts I've been to...in 5 different cities.
Also...does anyone have the UPC code or DPCI # on this item? I have the SKU...however I was told by a Wal-Mart employee that the UPC or DPCI # would be more useful, since they can't search on SKU#. What the ? I have always relied on SKU# in the past...so why not now?


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Buy: TLC4501IDR
IC OPAMP GP 4.7MHZ RRO 8SOIC Series: LinEPIC?, Self-Cal? Amplifier Type: General Purpose Number of Circuits: 1 Output Type: Rail-to-Rail Slew Rate: 2.5 V/?s Gain Bandwidth Product: 4.7MHz -3db Bandwidth: - Current - Input Bias: 1pA Voltage - Input Offset: 10?V Current - Supply: 1mA Current - Output / Channel: 50mA Voltage - Supply, Single/Dual (÷): 4 V ~ 6 V, ÷2 V ~ 3 V Operating Temperature: -40▲C ~ 125▲C Mounting Type: Surface Mount Package / Case: 8-SOIC (0.154, 3.90mm Width) Supplier Device Package: 8-SOIC HKinDataSheet_ZO1GOSIT
TLC4501IDR related keywords in 2017 United States
Copyright ©2017 Hong Kong Inventory Limited. All Rights Reserved.Designated trademarks and brands are the property of their respective owners. Use of this Website constitutes acceptance of Hong Kong Inventory Limited Terms of Use and Privacy Policy |


text: We Will Miss You, Bea ArthurHortense Smith4/25/09 4:07pmFiled to: BreakingBea arthur diesGolden Girlsbea arthursadnessGettypic23EditPromoteShare to KinjaToggle Conversation toolsGo to permalinkIn extremely sad news, beloved actress Bea Arthur has passed away at the age of 86. Arthur is perhaps best known for her roles as Maude and, of course, as Dorothy Zbornak on Golden Girls.According to the Associated Press, Arthur died peacefully in her sleep after a battle with cancer. "She was a brilliant and witty woman," said her personal assistant, Dan Watt. "Bea will always have a special place in my heart." In ours, too. Thank you Bea, for being a friend, and for bringing such joy and laughter to us all. You will be missed. [AP] In a small tribute to both Bea and Estelle Getty, here is one of my favorite clips (feel free to share your own in the comments): Reply23 repliesLeave a reply


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This release is available in German.
Genetic diversity arises through the interplay of mutation, selection and genetic drift. In most scientific models, mutants have a fitness value which remains constant throughout. Based on this value, they compete with other types in the population and either die out or become established. However, evolutionary game theory considers constant fitness values to be a special case. It holds that the fitness of a mutation also depends on the frequency of the mutation. Scientists from the Max Planck Institute for Evolutionary Biology in Pln and the University of British Columbia in Vancouver developed a model to address the scenario of mutations being frequency-dependent but having random fitness parameters. The results demonstrate that the dynamics that arise in random mutants increase the genetic diversity within a population. Fitness, though, may even decline.
Population geneticists generally study mutations with constant fitness values. However, frequency-dependent selection is a recurrent theme in evolution: it enables the evolution of new species without geographical separation (sympatric speciation) or a relatively rapid change in the immune system of a population.
A mutation may be advantageous for low frequencies, for instance, but the fitness of the mutant decreases with rising frequency. A reverse trend in the fitness value is also conceivable. "Our computer model combines aspects of population genetics and evolutionary game theory in order to obtain a new perspective on genetic evolution," says Arne Traulsen from the Max Planck Institute for Evolutionary Biology. Whereas mutations have a random yet fixed fitness value in many mathematical models, this new model also enables a change in random fitness values with the frequency of the different types.
The results of the simulations show that frequency-dependent selection leads to higher genetic diversity within a population of individuals even though diversity per se is not favoured. The interaction of different mutations and the emergence of new mutants support the development of dynamic diversity in the population. One mutant does not always need to replace all other mutations or the original population. "It is possible for different mutations to exist in parallel such that a new mutant does not to completely replace the residents," says Weini Huang, lead author of the study. What is particularly interesting is the fact that diversity in this model remains naturally limited.
Fitness, on the other hand, does not necessarily rise with frequency-dependent selection in contrast to constant selection. By way of example, a mutation may arise within cells which halts the production of substances that are passed on to other cells. This can initially be advantageous; however, if it reaches fixation, the average fitness of the cell population declines. Advantageous mutations can thereby be lost and deleterious ones become established.
Contact: Dr. Arne Traulsen email@example.com 49-452-276-3255 Max-Planck-Gesellschaft Source:Eurekalert |


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"The Walking Dead" sent more than a few humans scrambling to their Twitter accounts during its fourth season premiere Sunday.
The AMC drama, set in a post-apocalyptic world in which humans seek to evade flesh-eating zombies, placed at the top of the Nielsen's Twitter TV rankings for the week of Oct. 7.
The show attracted a television audience of 16.1 million viewers — a record for the series. It also generated a ton of chatter on social media, with some 1.2 million tweets attracting a Twitter audience of nearly 7.5 million, according to Nielsen's SocialGuide unit.
PHOTOS: Behind the scenes of 'The Walking Dead'
FX's horror anthology "American Horror Story: Coven" ranked as the second-most social program on TV, producing 435,600 comments and an audience of more than 4.6 million on Twitter.
The full rankings for the week, according to Nielsen:
- The Walking Dead (AMC), Sunday, Unique Audience: 7,491200, Tweets: 1,172000
- American Horror Story: Coven (FX), Wednesday, Unique Audience: 4,623,800, Tweets: 435,600
- Catfish: The TV Show (MTV), Tuesday, Unique Audience: 3,544,300, Tweets: 743,600
- The X Factor (FOX), Wednesday, Unique Audience: 2,393,300, Tweets: 422,900
- The Voice (NBC), Monday, Unique Audience: 1,972,200, Tweets: 115,000
- Jimmy Kimmel Live (ABC), Wednesday, Unique Audience: 1,942,500, Tweets: 57,100
- Dancing with the Stars (ABC), Monday, Unique Audience: 1,695,900, Tweets: 43,500
- WWE Monday Night RAW (USA), Monday, Unique Audience: 1,391,600, Tweets: 176,800
- Keeping Up with the Kardashians (E!), Sunday, Unique Audience: 1,215,600, Tweets: 32,900
- The Voice (NBC), Tuesday, Unique Audience: 1,147,800, Tweets: 49,000
CORRECTION: Due to erroneous information furnished by Nielsen, the social media reaction to "Glee's" tribute to the late Corey Monteith was omitted from the results for the week of Oct. 7. The show's send-off to Monteith produced 822,100 tweets that reached a Twitter audience of 5.2 million; ranking as the second-most discussed show of the week on the social media platform.
'Walking Dead' comes alive in ratings for AMC
Cablevision blasts broadcasters' Supreme Court filing against Aereo
Nielsen measuring audience of TV-related tweets during programs
ON LOCATION: People and places behind what's onscreen PHOTOS: Biggest box office flops of 2013 PHOTOS: Celebrity production companies


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Envisioning Architecture Conference 2011
location: BK City
From 14 to 17 September 2011, the 10th conference of the European Architectural Envisioning Association (EAEA) will be held at the faculty of Architecture TU Delft.
The conference series focuses on the visualisation of architecture and this year's themes will be composition, perception, representation and education.
A call for abstracts for the 10th EAEA conference led this year to more than fifty proposals, from which forty papers have been selected for presentation and publication at the conference. The contributions will be from international institutions from Europe the United Kingdom, Germany, the Netherlands, Belgium, France, Italy, Portugal, Poland, Slovakia, Austria and Turkey), the Americas (Brazil and the United States) and the Far East (Taiwan, Malaysia, the Philippines, Korea, Japan and New Zealand). All papers concentrate on the themes of composition, perception, representation and education.
The European Architectural Envisioning Associaton
The EAEA was formerly known as European Architectural Endoscopy Association and started as a gathering of professionals who examined the visualization practice in architecture. The focus was on visual simulation of the effects of environmental interventions using optical instruments: 'capturing' photographic or analogue (video) images using physical scale models, generally using a viewing pipe.
From the first session onward the exclusive focus on optical endoscopy began to shift, first gradually, then more and more steadily towards other environmental visualization opportunities, notably using digital media. Apart from the quality and content of visualization, the aspect of the Modelling as such also became a recurring theme. Noteworthy developments included the increasingly adaptable, distinctive and indeed elegant modes of digital representation, but also the use of (digital) photography and film, the opportunities of combined media and graphics, but also the introduction of disciplines such as Experimental Aesthetics and Virtual Archaeology.
Because of this shift the name of the association was eventually changed into European Architectural Envisioning Association. This new namefittingly evokes the shared ambitions for a dynamic architectural visualisation practice and the continued exchange of ideas concerning the imaginative conception of future environments
Programme (provisional):
Wednesday, the 14th of September 2011
- Registration at the Faculty of Architecture
- Welcome by the Dean and the conference organisers
- Paper session 1
- Keynote address 1: prof. Michiel Riedijk, Delft, the Netherlands and Neutelings Riedijk architects (lecture hall A)
Evening: conference dinner in Delft
Thursday, the 15th of September 2011
- Paper session 2
Lunch in the South Atrium / Form Studies hall BK
- Paper session 3
- Keynote address 2: prof. Francis D.K. Ching, Seattle, USA (lecture hall A)
(Evening: meeting of the Scientific Committee EAEA with delegates of the DCA)
Friday, the 16th of September 2011
- Paper session 4
Lunch in the South Atrium / Form Studies hall BK
- Paper session 5
- Keynote address 3: prof. Ralf Weber, Dresden, Germany (lecture hall A)
Evening: conference dinner at the Science Centre TU Delft
- Official closing and evaluation EAEA10
Saturday, the 17th of September 2011 – morning and afternoon
- Excursion Randstad Holland / Rotterdam including a visit to Dutch Architecture Institute (NAi).
More information
For more information: http://tinyurl.com/eaea10.


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North People
Wednesday, October 11th, 2006The name Norfolk means "north people" and the name Norwich means "north village." The names, I am told, are Scandinavian in origin. So if you think about it North Norwich is actually, North North Village.
The group of foreign travelers coasted through our small city a few days ago. We were fortunately a welcomed and convenient stop between Canada and New York City. The community made preparations giving honors and hospitality to the English and the Australians. The delightful group of people carried with them a casual foreign charm and a delightfully quick wit. The congregation visited our local school and shared a part of their heritage with our local legacy. The children roared and laughed and seemed to enjoy themselves. I must admit if I were in their shoes I wouldn't have liked to come in for my day off and a few of us adults passed guilty snickers at the notion. I was impressed with the "Madame principal" as Derek Bigford-Smith called her – Michelle Donlon was nearly as enthusiastic as the children. The vistors themselves seemed very relaxed. Something I believe is that, at least in the beginning, all children in all countries are the same; I find that to be an encouraging thought.
The banquet was equally an event of interest. Gifts were exchanged and humors shared. Laughter echoed in the background of the ballroom the entire evening. I personally found our visitors to be of great interest; I have always had a profound desire to experience the outside world. After a wonderful dinner, I retired briefly to the bar to get myself a drink and then head home. A few of the visitors came in a few moments later and I had my drink with them. It was a marvelous experience. We talked of few things seriously and I spent the hour tentatively listening and laughing.
Here is a joke that is in fair taste I wanted to share.
A man was walking along the river in Norwich. He was a good man and he had lived a good life. The man loved God and read his bible well. Suddenly the clouds above opened up and heaven appeared before him. The man gasped, and the lord spoke ,"You are a good man, a great man and thus I offer you one wish to have anything you like." The man, stunned, began to think hard and after a moment of intense thought glanced up to the heaven and said, " I am going to California in a week and I think it would be awfully swell if you could make me a bridge from California to Hawaii. Then I could get a chance to see some truly beautiful sights." God seemed puzzled with the response and said, "Do you realize what you ask, the ocean is so vast and deep, the winds and current so powerful. It would take vast resources and a number of incredible engineering feats to achieve that. You ask too much, perhaps my friend you would reconsider." The man nodded in humility and thought again. After a moment he raise his head and asked "OK God, can you tell me what women think, I mean I really can't tell what they're thinking when they're look at me, or when they ask questions about their looks or whatever. I never know what to say and I would really just like to know what they really want." There was a long silence in heaven and finally God asked, "Did you want that bridge to be one lane or two?"
-English Joke


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This beautiful leather collar is part of the exclusive zoolove from zooplus collection. The zoolove Dog Collar with Hearts is made from vegetable tanned cow hide. The dark brown oiled leather is very durable yet soft and supple. The collar is fastened with a roll buckle and there is a silver metal D ring incorporated in the collar. The smooth leather is lined to prevent rubbing or chafing and comfortable to wear. It is studded with silver hearts. Your dog will look stunning when it wears the zoolove Dog Collar and you are helping pets in need because 10%* of the sale price of each zoolove product goes to a selected animal charity. The zoolove Dog Collar with Hearts glance Premium leather dog collar made by Heim Supple cow hide Vegetable-tanned and oiled Double layer For strength and durability Rounded edges To prevent chafing and rubbing Elegant design Studded with silver hearts Roll buckle and stainless steel D-Ring Made in Germany Material Collar Cow-hide leather leather lining Buckle/D-Ring Nickel-plated iron Colour Brown * = excluding VAT Just a little means a lot - zoolove cares! The leather lead shown in the photos is not included in the delivery. You can find the matching zoolove lead here. Sizes and Dimensions Collar size Neck circumference Width 35 22 - 30cm 22mm 45 30 - 40cm 22mm 55 38 - 50cm 30mm 65 48 - 60cm 30mm (function(d s id) { var js fjs = d.getElementsByTagName(s)[0]. if (d.getElementById(id)) return. js = d.createElement(s). js.id = id. js.src = //connect.facebook.net/en_GB/sdk.js#xfbml=1&appId=743041095711802&version=v2.0. fjs.parentNode.insertBefore(js fjs). }(document script facebook-jssdk)).
Check stock and price


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Replacement Model:
Abt Card
Product Questions - Ask
Average Customer Reviews
LG Smart TV
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Approximate Weight:
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(based on 4 reviews)
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By slblkit
from new york, ny
Comments about LG 65" Ultra HD Cinema 3D 4K LED Smart HDTV:
this is by far my favorite television! the picture is breathtaking and the graphics on my kids' high end video games is awesome. great feature for 2 players using video game glasses as well. all our friends want to come to our house to watch movies!
The best TV I ever had, top quality and picture !!
By Fischer
from Germany
I could say its a great picture and very good looking 3D. Lots of user settings for tweaking the right picture for night/day/3D watching. Does not have HDMI 2 which will limit ultra 4k resolution whenever true 4k content becomes really available. Very nice picture upscaling for Blu-ray, 4k Blu-ray. Blu-rays do look better and the 4k Blu-rays are even better. Best Quality but this i know from LG.
Absolutely stunning
By flshjack
from Arlington, TX, USA
Have been looking at 4K TV for a while and when I found this one I pulled the trigger. I have nothing but great things to say. All good. I wish it had more HDMI connections. My wife is spellbound by the picture. I may not ever go outside again. easy to program. The 4K upscale is fantastic. Can't wit for 4K content to be more readily available. The on board speaker are the best I have ever heard. All around great product, well worth what I paid and got.
This is an awesome TV
By Pete59
from Jacksonville, Fl
I did not realize that I could watch any TV in 3D until I bought this TV. I am enjoying everything about this TV, It's like being at the movies every day.
Fill out the form below to request Better Price for this product.


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Larry Griffin
Larry Griffin (September 23, 1954 – June 21, 1995) was sentenced to death for the murder of 19-year-old Quintin Moss. The crime occurred in St. Louis, Missouri on the afternoon of June 26, 1980.
Moss was killed in a drive-by shooting while allegedly dealing drugs on a street corner.
Appeals courts upheld his conviction and death sentence. Griffin was executed by lethal injection on June 21, 1995. Griffin maintained his innocence right up to his execution.
Re-opened investigation[edit]
After Griffin's execution, a 2005 post-execution investigation was sponsored by the NAACP Legal Defense and Educational Fund. This NAACP investigation raised doubts about the conviction (specifically as to the shooter's identity), and subsequently caused an investigation by the St. Louis City Circuit Attorney's Office. The St. Louis City investigation ended in a finding that "the right person was convicted".
See also[edit]
External links[edit]
- Article on the Web
- Editorial from NY Times
- Article from NY Times
- Equal Justice
- Did Missouri execute an innocent man?. MSNBC (2005-07-12). Retrieved on 2007-11-20.
- Missouri death sentence case gets another look. MSNBC (2005-08-05). Retrieved on 2007-11-20.


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If you want a family sport boat that can operate where stern drive rivals dare not tread and is also a serious fishing machine, Robalo's versatile R247 is in a class by itself. There's so much to like about the R247. Kevlar reinforcement and stainless steel hardware are a cut above. A have-it-your-way options list is accented with an innovative three position portside seat, a clever wet bar, vacuflush head, special electronics and an assortment of custom tops and towers. Search all the leading competitors and you won't find a dual console in this size range with more storage. Everywhere you look there's room for cargo...under all the seats, in the starboard console, in the floor and at the bow.In stock and available today. Also offering a 5 year engine and component warranty.
Yamaha 300 HP 4-stroke, comfort package, entertainment center, bow and cockpit covers, hard-top complete, Garmin VHF and Map, underside top gelcoat, double seat port side, stainless steel cleats with Robalo, wide band Shark Gray hull and electric toilet.


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Strong Safety Signal Seen for New Varenicline Risks
A strong signal of multiple safety problems with Chantix (varenicline), a drug to help people stop smoking, has been seen in a pilot program to identify new drug risks in adverse drug events reported to the U.S. Food and Drug Administration.
Varenicline is suspected in various adverse drug event reports of causing a wide spectrum of injuries, including serious accidents and falls, potentially lethal cardiac rhythm disturbances, severe skin reactions, acute myocardial infarction, seizures, diabetes, psychosis, aggression and suicide. The cases were analyzed and classified using computerized excerpts of adverse event reports which the FDA publishes for research use.
The FDA approved varenicline in May 2006 after granting it a priority review. Varenicline is a partial agonist of one of the nicotinic acetylcholine receptors in the brain and nervous system, 1 and currently the only marketed and approved drug with this mechanism of action.
In the
4th quarter of 2007 varenicline accounted for 988 serious injuries
in the
The FDA has recently issued a Public Health Advisory about one of the most marked adverse effects of varenicline, psychiatric symptoms that included "changes in behavior, agitation, suicidal ideation, attempted and completed suicide." 2 However, the FDA alert provided no information about the numbers of reported neuropsychiatric events among treated smokers.
From May 2006 through December 2007, the FDA had received 227 domestic reports of suicidal acts, thoughts or behaviors, 397 cases of possible psychosis and 525 reports of hostility or aggression. These totals included 28 cases of suicide and 41 mentions of homicidal ideation, 60 cases of paranoia and 55 cases of hallucination. The categories were not mutually exclusive.
However, the adverse drug event reports for varenicline describe other kinds of serious harm for which no warnings now exist, either from the FDA or from the manufacturer, Pfizer Inc. The cases (including those with psychiatric effects) were classified using standardized medical queries developed by the pharmaceutical industry to identify potential adverse events in clinical studies and postmarket surveillance. Adverse event reports in themselves do not establish a causal link to the drug, only that an observer suspected a relationship. Depending on the features of the specific event, it could be counted in multiple categories, and classifications are not definitive. Among the most prominent were:"
· Accidents and injuries. A total of 173 serious events described accidental injury, including 28 road traffic accidents and 77 falls, some leading to fractures of rib, facial bones, hand, ankle, spine, and lower limbs. In these cases a variety of potential causes were identified, including loss of consciousness, mental confusion, dizziness and muscle spasms.
· Vision disturbance. At least 148 reports contained medical terms indicating vision disturbances, including 68 cases described as blurred vision and 26 terms indicating transient or other forms of blindness. This reported effect could also describe a mechanism that could or did contribute to accidents and injuries.
· Heart rhythm disturbances. The FDA received 224 domestic reports classified as potential cardiac rhythm disturbances. This category, however, was dominated by reports of sudden loss of consciousness, an event that could also have non-cardiac causes. However, this category also included smaller numbers of cardiac arrests and identifiable abnormal cardiac rhythms
· Seizures and abnormal muscle spasms or movements. Serious reported events included 86 cases of convulsions (seizures), 372 reports of a wide variety of movement disorders, including tremors, muscle spasms, twitching, tics, drooling, and motor hyperactivity. The extent to which these problems resolved with a reduced dose or by halting treatment could not be determined from these data.
· Moderate and severe skin reactions. Reported serious events included 338 cases of hives or swelling of the tongue, face, eyes, lips or other areas. In addition, 65 cases were classified as severe and included blisters, exfoliation of the skin and lips, and Stevens-Johnson Syndrome.
· Diabetes. The FDA has received 544 reports suggesting varenicline may be related to a loss of glycemic control. This category included many cases of weight loss or gain that could have alternative causes, but also identified numerous cases of symptoms and laboratory tests consistent with new onset diabetes.
We have immediate safety concerns about the use of varenicline among persons operating aircraft, trains, buses and other vehicles, or in other settings where a lapse in alertness or motor control could lead to massive, serious injury. Other examples include persons operating nuclear power reactors, high-rise construction cranes or life-sustaining medical devices. Based on reports of sudden loss of consciousness, seizures, muscle spasms, vision disturbances, hallucinations, paranoia and psychosis, we believe varenicline may not be safe to use in these settings. The extent to which varenicline has already contributed to accidental death and injury has not yet been investigated because these adverse effects had not been previously reported. The Federal Aviation Administration approved varenicline for use by airline pilots3 before most of these reports were available.
In addition, we recommend that patients and doctors exercise caution in the use of varenicline and consider the use of alternative approaches to smoking cessation.
Finally, we urge the FDA and the manufacturer to provide warnings to doctors and patients for those adverse effects that can be adequately documented through existing data, and to undertake on a priority basis epidemiological studies or other research to assess other potential risks. We promptly notified the FDA of our findings.
This report was written by:
Thomas J. Moore, Senior Scientist, Drug Safety and Policy, ISMP
Michael R. Cohen
Curt D. Furberg, MD, PhD, Professor of Public Health Sciences,
Institute for Safe Medication Practices
Corresponding Author
Thomas J. Moore
Full Report
Varenicline was approved as an aid to
smoking cessation treatment, joining nicotine replacement products and the
antidepressant drug buproprion, marketed as Zyban, for this medical use. Varenicline,
however, was reported to achieve its effect through a novel mechanism of
action, through partially blocking and partially stimulating a type of nicotinic
acetylcholine receptor. It was derived from cytisine, an antismoking drug used
Pfizer research scientists who developed the drug focused on a particular role played by one of the subtypes of receptor, the α4β2. Varenicline was most active against this subtype and specifically these receptors increase the release of dopamine in the brain.5 Dopamine, in turn, plays a major role in addiction, mood, and muscle movement. Many antipsychotic drugs block dopamine receptors, but they also cause movement disorders. The loss of muscle control seen in Parkinson's disease is the result of the destruction of dopamine-producing cells in the brain. Pfizer scientists theorized that the mixture of blocking and stimulating nicotinic acetylcholine receptors would replace some of the pleasure of smoking through stimulating dopamine release, and block or reduce the effects of nicotine when present.
In clinical studies, varenicline produced 52-week quit rates of approximately 22 percent. 6-9 Similar quit rates have been observed in nicotine gum, 10, 11 although Pfizer has claimed an advantage over the nicotine patch in a comparative study it conducted. 6 However, the varenicline results may not be achieved in clinical practice because the initial 12-week treatment program included weekly clinic visits with counseling. More importantly, both the benefits and the safety profile of varenicline were likely influenced by the type and number of patients excluded from the Phase 3 trials. For example, the longest varenicline safety and efficacy trial excluded patients with the following : 12
· Recently treated for depression, bipolar disorder, psychosis or panic disorder.
· Experienced clinically significant allergic reactions to any drug.
· Had any abnormal laboratory findings.
· Cardiovascular disease within six months
· Were using over-the-counter or prescribed stimulants or diet pills
· Had a history of drug or alcohol abuse or dependence
The trials also prohibited concomitant use of other psychologically active drugs, including stimulants, antidepressants, tranquilizers, antipsychotics, mood stabilizers, naltrexone and anticonvulsants.
Varenicline was approved first in
Why this study
was conducted
The signal for varenicline was observed in an Institute for Safe Medication Practices (ISMP) pilot program to identify emerging drug risks and new medication errors through monitoring FDA adverse event reports on a quarterly basis. The agency publishes computer excerpts of adverse events from which all identifiable personal information has been removed. The report narrative is replaced by a series of medical terms that describe the event that has occurred.
Adverse event reporting is voluntary for consumers and health professionals. However, manufacturers are required to investigate and report all adverse events of which they happen to learn. The reporting rate is unknown, variable and poorly studied. Crude published estimates suggest that from 1% to 10% of serious adverse events are reported. 14 We maintain a copy of all adverse events reported to the FDA--which is thought to be one of the largest drug safety databases in the world.
Two analytical approaches have traditionally dominated the use of these adverse event data. One technique, called a case series, is to analyze a group of carefully selected, uncomplicated reports. The FDA itself analyzes its adverse event data on a case-by-case basis. A second approach, called data mining, searches for signals through unexpected connections between drugs and event characteristics.
The signal for varenicline, however, was identified using a third approach, which was to monitor the flow of quarterly reports in order to detect changes in the numbers of serious events and other trends.
Varenicline crossed a first signal
threshold in the 4th quarter of 2006 when it appeared for the first
time among a small group of drugs that accounted for 100 or more reports of
serious injury in a calendar quarter.
By the 2d quarter of 2007 it ranked 3d among all drugs in the
By the
3rd quarter of 2007 varenicline produced a signal not previously seen for any
other drug. It produced more serious
reports than any other drug for multiple types of events: more potential cases of angioedema, cardiac
arrhythmia, diabetes and severe cutaneous injury. By the 4th quarter
of 2007 varenicline accounted for more reports of serious drug adverse events
in the
Table1. Leading Suspect Drugs 2007/Q4* | |
Drug |
Cases |
Varenicline |
988 |
Beta |
640 |
Etanercept |
555 |
Infliximab |
554 |
Fentanyl |
404 |
Oxycodone |
372 |
suspect drug/US only/serious |
The cases
selected for this analysis are shown in Table 2 and consist of all
2. Case Selection | ||
Number |
Pct |
Reports |
6363 |
100% |
Exclusions* |
Prior reports |
1509 |
23.7% |
Foreign |
1608 |
25.3% |
Not serious |
473 |
7.4% |
Not principal suspect |
415 |
6.5% |
Cases selected |
3063 |
48.1% |
*Report could be excluded for more
than 1 reason |
Table 3 describes the 3063 reports included in this analysis. The FDA defines a serious adverse event as one that results in death, disability, a birth defect, hospitalization (initial or prolonged), is life threatening or requires intervention to prevent harm. The agency also allows an "other serious" category that might include events such as skin cancer or cardiac rhythm disturbances that did not result in hospitalization.
The patients characteristics show those experiencing serious injury were predominantly female (69%) and median age was 50. Compared to our previously published assessment of all reports to the agency over an 8-year period, 14 the varenicline reports have a greater share of reports from females (69% vs 55%), from consumers (57.3% vs 25.9%), and a substantially lower proportion of reported deaths (2.5% vs 17% ).Varenicline also had a smaller proportion of reports submitted directly to the FDA (8% vs 19%) probably because of problems with the classification of "other serious" adverse events.
3. Reports Overview |
n =
| ||
Type |
Number |
Pct |
Direct to FDA |
246 |
8.0% |
Mfr-Expedited |
2817 |
92.0% |
Mfr-Periodic |
0 |
0.0% |
Source |
Consumer |
1755 |
57.3% |
Health Professional |
1045 |
34.1% |
Lawyer |
2 |
0.1% |
None Stated |
261 |
8.5% |
Group |
Death |
78 |
2.5% |
Disability |
64 |
2.1% |
Serious |
2921 |
95.4% |
Population |
Median age |
50 |
Percent female |
69% |
To evaluate types of reactions we used Standardized Medical Queries (SMQ) developed by the pharmaceutical industry to identify types of adverse reactions in clinical trials and postmarketing adverse event reports. 15 The SMQs were developed with explicit medical criteria and subject to validation testing. However, these selection criteria do not provide definitive assessments but rather are intended to identify potential cases for additional review. To identify vision disturbances, we used a similar but slightly different kind of category called a High Level Group Term (HLGT) which is used to group similar medical terms in various body systems. 16
In Table 4 we provide event counts for selected SMQs that were chosen for biological plausibility, association with other drug therapy, appropriately specific criteria, and substantial numbers of cases. Because the individual SMQs varied in specificity and suitability we evaluate the strengths and weaknesses of individual SMQs shown in the discussion section.
4. Selected Adverse Event Types* |
Cases |
and injuries |
173 |
338 |
arrhythmias |
224 |
86 |
and thrombotic events |
139 |
syndrome |
372 |
onset diabetes mellitus |
544 |
525 |
and psychotic disorders |
397 |
Suicide/self-injury |
227 |
cutaneous adverse reactions |
65 |
disturbance** |
148 |
frequently occur in multiple SMQs |
** Event
type selected by High Level Group Term |
While varenicline was the principal suspect drug in every case included in this report, the patients frequently were taking other medication. Among the serious injury cases, patients were taking a median of 2 other medications that included prescription drugs, over-the-counter drugs, vitamins, herbal products, calcium supplements and alcohol. However, one-third of all cases involved no other reported medication; another 14% listed only one other medication. At the other extreme, in 10% of the reported cases the patients reported taking nine or more medications. A total of 126 cases included a report term indicating a suspected drug interaction.
The top 10 most frequently listed other medications are shown in Table 5 and are widely used over-the-counter and prescription medications in this patient population. However, numerous other cases did include co-administration of psychoactive drugs including antidepressants, antipsychotic drugs and opioid analgesics.
5. Other medication taken | |
n = 3063 | |
Compound |
Cases |
Multivitamins |
250 |
acid |
248 |
Alprazolam |
216 |
Atorvastatin |
184 |
Levothyroxine |
180 |
Albuterol |
175 |
salmetrol |
161 |
Estrogens |
159 |
Metoprolol |
146 |
Clonazepam |
145 |
An additional perspective on the adverse event profile of varenicline may be seen in Table 6—a ranking of the most frequent specific medical terms extracted from all reports. It serves as a crosscheck of the adverse event reports because these terms can be compared with clinical trial results and the product labeling. Note that each report contains one or more terms. (For example a report might cite nausea and abnormal dreams or headache and weight increased.)
Table 6. Frequent Medical Terms | |
n = 3063 | |
Nausea |
593 |
Depression |
287 |
Insomnia |
242 |
Dreams |
238 |
Feeling Abnormal |
223 |
Vomiting |
221 |
Anxiety |
217 |
Dizziness |
216 |
Headache |
215 |
Fatigue |
184 |
Ideation |
159 |
Dysponea |
158 |
Malaise |
157 |
Increased |
141 |
Decreased |
136 |
In the
data provide a strong signal that the risks of varenicline treatment have been
underestimated, and show that a wide spectrum of serious injuries are being
reported in large numbers. In addition to the data analyzed for this report are
1608 foreign reports that are consistent with the results reported here. Drug regulatory authorities in
Table 1 shows that in the 4th quarter of 2007, the other highest ranked drugs (e.g. fentanyl, interferon beta, etanercept) are all high alert drugs with black box warnings, are intended for serious illness in patients and have benefits that are accompanied by substantial risks. In comparison, varenicline is intended for use in healthy people to help stop smoking.
In addition, most of these potential adverse events are biologically plausible effects of a novel drug altering the function of a neuroreceptor performing many important functions throughout the body.
While it is likely that some individual reports will describe complex events for which there are alternative causes or contain other information to render a relationship to the drug less likely, the sheer number of reports is large for most event types listed.
However, the SMQs provided varied levels of confidence in ascertaining specific types of adverse events. Some SMQs (notably accidents, angioedema, convulsions, severe cutaneous injury) are relatively clear description of specific adverse events frequently linked to drug therapy. While scrutiny of each individual case might uncover alternative mechanisms of causation, it seems unlikely that all or even most could be discounted.
The two cardiac SMQs (cardiac arrhythmias and embolic/thromboembolic events) raise special problems of interpretation. In the case of the cardiac arrhythmias, many of the cases were thus classified because of reports of syncope and loss of consciousness. These events could be occurring through other mechanisms. In the case of embolic/thromboembolic events the challenging issue is alternative causation. While the cases included numerous reports of heart attack, stroke or pulmonary embolism, a population of smokers trying to quit can be expected to have numerous risk factors for such events. Establishing a link to these serious but common medical disorders is problematical without data from controlled clinical trials. We note, however, the FDA voiced similar uncertainty in its safety review of varenicline: "The serious adverse event data suggest that varenicline may, possibly increase the risk of cardiac events, both ischemic and arrhythmic, particularly over longer treatment periods. This finding is far from definitive." 19
The diabetes SMQ raised different issues of interpretation. While 544 cases is a large number, this category was dominated by many cases of weight gain and weight loss. Weight gain in particular would be expected in a population giving up smoking. Even disregarding these cases, the category included numerous cases involving elevated blood glucose, hunger, thirst, frequent urination—all classic indications of new onset diabetes mellitus.
An additional question is the extent to which the large volume of reports, notably the neuropsychiatric events, might be explained by preexisting illness or other psychiatric drugs that were also being taken. However, these data show that no other drug was listed in one-third of all serious events, and numerous other medications—such as multivitamins, cholesterol lowering drugs, calcium supplements and estrogens—would be unlikely suspects. However, since the clinical trials of varenicline prohibited taking an overwhelming majority of drugs active in the nervous system, we cannot exclude the possibility of a potent interaction with one or more other drugs, especially psychiatric drugs.
Strengths and limitations
of these data
The data used for this report have several strengths. Because of the large numbers of patients exposed to the drug, these data are capable of detecting events that might not show clearly in relatively small, relatively short clinical trials. A large share of these reports were investigated and submitted by the drug manufacturer, presumably with consistent procedures, and potential events were selected using criteria that had been previously undergone validation testing. In addition, these events occurred under real world conditions and not the narrowly selected patient population in the clinical trials.
Nevertheless, these data have sufficient limitations that we describe these overall findings as a signal that requires further investigation and confirmation. Among the most important limitations are that these reports do not establish causality; most patients were taking multiple drugs; the event classification tool is limited to identifying potential cases and is not definitive. Reporting is voluntary for consumers and health professionals and little is known about reporting rates. Crude published estimates show that from 1% to 10% of all serious events are reported, but with wide variation among drugs, event times and over time.
An additional possibility to consider is whether the varenicline report totals were artificially increased by some factor not apparent in the reports themselves. For example, large numbers of reports for thalidomide are submitted because a controlled access program for all patients causes the manufacturer to learn about and report all serious events that occur.
Adverse event reporting rates can also be increased by media publicity about FDA warnings or other actions that publicize a drug adverse effect. On November 20, 2007 the FDA published an "Early Communication" about reports of "suicidal thoughts, aggressive acts and erratic behavior." 20 Then, on February 1, 2008, the agency issued a more formal warning, a Public Health Advisory. 2
We judged it unlikely that publicity from the FDA's initial "Early Communication" in late November a significant effect on the reporting rate. There is a substantial lag that involves the time for public awareness to develop about a newly reported drug risk, for a manufacturer to receive the information and write an initial report, its transmission to the FDA and appearance in the FDA system. In addition, it seemed unlikely that publicity about neuropsychiatric adverse events could account for reports of other serious but unrelated adverse events. However, it would not be surprising to discover publicity over the FDA's February 2008 health advisory contributed to increased reports in the first quarter of 2008.
It is likely that Pfizer's direct to consumer marketing program could have generated additional reports. The Chantix web site offers email and telephone coaching. Through this mechanism, the company could learn of serious adverse events which it would be required to report. On the other hand, these reports should be of high quality, since the company would anticipate that this effect would occur. All these effects tend to drive the voluntary reporting rate closer to the true incidence.
We emphasize the recommendations outlined in the executive summary. We have concern about the use of varenicline by persons in settings where the risk of accident is high; we recommend doctors and patients exercise caution in the use of varenicline and consider alternative methods of smoking cessation. The FDA and the manufacturer should on a priority basis assess the information available and conduct additional research where current data are insufficient to resolve questions about the safety of varenicline.
Reference List
(1) Prescribing Information for Chantix (varenicline) Tablets. Pfizer Inc.; January, 2008.
(3) Silberman W S. Certification Update. Federal Air Surgeon's Medical Bulletin. 2008;45:3-4.
(4) Etter JF. Cytisine for smoking cessation: a literature review and a meta-analysis. Arch Intern Med. 2006;166:1553-9.
(5) Coe JW, Brooks PR, Vetelino MG et al. Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation. J Med Chem. 2005;48:3474-7.
(6) Aubin HJ, Bobak A, Britton JR et al. Varenicline versus transdermal nicotine patch for smoking cessation: Results from a randomised, open-label trial. Thorax. 2008.
(7) Nides M, Oncken C, Gonzales D et al. Smoking cessation with varenicline, a selective alpha4beta2 nicotinic receptor partial agonist: results from a 7-week, randomized, placebo- and bupropion-controlled trial with 1-year follow-up. Arch Intern Med. 2006;166:1561-8.
(8) Gonzales D, Rennard SI, Nides M et al. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial. JAMA. 2006;296:47-55.
(9) Oncken C, Gonzales D, Nides M et al. Efficacy and safety of the novel selective nicotinic acetylcholine receptor partial agonist, varenicline, for smoking cessation. Arch Intern Med. 2006;166:1571-7.
(10) Kornitzer M, Kittel F, Dramaix M, Bourdoux P. A double blind study of 2 mg versus 4 mg nicotine-gum in an industrial setting. J Psychosom Res. 1987;31:171-6.
(11) Hjalmarson AI. Effect of nicotine chewing gum in smoking cessation. A randomized, placebo-controlled, double-blind study. JAMA. 1984;252:2835-8.
(12) Winchell
CJ. Supervisory Review of NDA Safety Review and Primary Clinical Eficacy Review
(13) Form 10-K Pfizer Inc. Pfizer Inc; February 29, 2008.
(15) MedDRA
Service and Support Organization. Introductory
Guide for Standardized MedDRA Queries (SMQs) Version 10.1.
(16) International
Conference on Harmonization Points to Consider Working Group. MedDRA Data
Retrieval and Presentation: Points to Consider.
(17) Health
(18) European Medicines Agency. Questions and Answers on the EMEA's Action Regarding the Safety of Champix. European Medicines Agency. December 14, 2007. http://www.emea.europa.eu/pdfs/general/direct/pr/Champix_Q&A_59565807en.pdf. Accessed May 9, 2008.
(19) Josefberg
H. Clinical Safety Review: Varenicline tartrate.


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- Horse Health
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My horse kicks when being groomed G'day My horse has started to kick when I brush him he never done it before he usally loves it but every time I brush near his rump he kicks violently is it pain related or just bad behavior :-( |
Usually this is pain related - my first guess would be ulcers (if there's no obvious injury in this area). Is he disrespectful at other times? Does he only do it with stronger pressure or any touch at all? I would have a vet out if a typically happy horse started acting out with grooming. |
Yes he is disrespectful at other times but he knows I'm boss and hasn't gone as far as aiming a kick a me untill he get a bullseye and it wasn't under pressure ! |
Well I don't think getting him checked out by a vet would hurt - but if you're inclined to think it's a behavioral thing maybe some groundwork/manners building is in order? |
;-)Won't hurt to do both |
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It's hard to tell with chance because everything bothers him. It was getting dark when I was brushing him so I might have missed something I'll have look in the sunlight today |
Everything bothers him? that is something to think about. I'd hate to have a young horse that everything bothered. Do you mean things touching him? or humans holding him? being tied up? The last thing you want is to have a horse that everything bothers. you would want to work on those things before going on to anything else. |
What I mean by everything bothering him is because he is moody if he hungry and wants to get back to his mates he will chew things move around stomp his feet until he back with his mates. |
He doesn't like to be fussed over. And he will test your limits to but when there's work to be done he's the best horse around. |
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