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A Sargent Portrait
It took half a century for his critics to see his subjects as clearly as he did; but today he stands as America's preeminent portraitist
October/November 1986 | Volume 37, Issue 6
Mrs. Henry White, on the other hand, whose husband was a diplomat, is equally unmistakably American. She stands, tall, proud, and beautiful, with the confidence wrought of grace, discipline, lineage, and money, and yet for all this she is not quite sure that she is going to be, in the glare of London "crushes," the success that she deserves to be. But she may if she tries, and God knows she will try! One can feel it in the serene resolution of her stare and in the way the fingers of her left hand grip those opera glasses. Allan Nevins, Henry White's biographer, told me once of a contemporary of his subject who had described the difference between Mrs. White's greeting of a duke and of a commoner as "aweinspiring."
A second American woman, Lady Astor, does not have Mrs. White's intensity; she is simply radiantly confident of the inexhaustible supply of her own beauty and energy. In this charming picture Sargent evokes all the fervor and idealism of a new world turning back to conquer the old. It is almost too much. Do we catch a hint of the bossy, eccentric old parliamentarian in the foxy smile and coy pose of this dazzling creature? Perhaps I am going too far, but if Sargent saw all, he may have seen the future.
When the sitter had no distinct character of face, Sargent made up for it as best he could in the costume and setting. Mrs. Hugh Hammersley is a case in point. One sees that she was a vapid, amiable, very pretty Englishwoman, but the dignity of her rich pink dress and of the lavish gold background redeem the picture. Henry Adams was much struck by this. Was Sargent consciously insulting the whole money culture, he wondered? Was he intent on exposing the soul (if there was one) of the female "goldbug"? I do not think so. Sargent was simply painting what he saw.
Even when the sitter was not sympathetic, even when she posed reluctantly and then refused to finish, as did the lazy, shallow Mme. Pierre Gautreau, he was able to make a masterpiece. She stands before us, the embodiment of female vanity, with nothing, absolutely nothing, to justify it but the incomparable beauty of her body and skin, which she shows off in a pose so effectively dramatic as to excuse its absurdity.
Sargent was to some extent the victim of his own success. The world thronged to his studio, and no matter what he charged for a portrait, the world was willing to pay. Friends intervened to plead with him to take this or that sitter; it was hard to say no. A popular cartoon showed him looking from his studio window in despair at the long line of elegant carriages clogging Tite Street. Eventually the sheer quantity of the work began to take its toll on the quality. One feels in some of the later portraits that the artist is beginning to be bored. The decline can be seen by contrasting The Wyndham Sisters , of 1899, with The Marlborough Family , done six years later. The former shows the master at the height of his powers: the dazzling white of the dresses against the somber background makes it a dramatic triumph. The duke and duchess, on the other hand, standing in a stiff, unlikely pose with two sons and two Blenheim spaniels on a grand marble stairway under draped war banners, seem dull and pompous. One can see why Sargent, his pockets now full, sought to give up the portrait business in 1907.
It remained, one is happy to add, for him to do his finest watercolors, and charcoal sketches, some as good as any of his portraits.


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Demi Lovato Confirms an R-Rated 'Camp Rock 3'!"It'll be like American Pie meets Disney Channel!"
These Pictures of Joe Jonas Will Make You Stop BreathingA happy hump day, indeed.
Joe Jonas is Officially Dating this 'Game of Thrones' StarThe couple posed for a few photo booth pictures alongside Nick Jonas. Later in the evening, the brothers mugged it up for the camera, cigars in hand.
Joe Jonas Reveals He's into S&M in the BedroomJoe Jonas's Disney days are decidedly over.
DNCE Talks Sex on New Album, Possible Michigan Tour DatesTheir album drops tomorrow - the band tells us what to expect, and when we might see them here.
Nick Jonas Meets his Niece for the First Time in Heartwarming PhotoWe are not worthy of this much cuteness.
Joe Jonas Spotted on Date with 'Game of Thrones' Star [PHOTOS]Things are burnin' up between Joe Jonas and a 'Game of Thrones' star.
Joe Jonas Accidentally Sent a Bunch of Porn to his Family's House"You naughty boy. Come visit us again."
Joe Jonas Reveals How Disney Pressured the Jonas Brothers"The kind of pressure that no teenager should be under."
Did Ashley Greene Respond to Joe Jonas's Story About Losing his Virginity to Her?She seems like she wasn't too impressed with her ex's candor.
Joe Jonas on Losing Virginity and Jonas Brothers Breakup"I didn't have any condoms, so I went to our drummer, Jack's room, and I demolished his room looking for them."
Exes Joe Jonas and Demi Lovato Got Stuck in an Elevator for HoursGood thing these two get along!

subset: commoncrawl


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A few months ago, I was visiting with my in-laws. We were making plans for the day, and I mentioned that my only "to-do" was to take a nap around 2:45pm later that day. That would give me plenty of time to fit in our lunch plans, while ensuring that I had a good nap before we headed out for an early dinner that evening. Everyone agreed, and we went on about our morning.
Lunch came and went, and the clock was nearing 2:30pm. Everybody noted the time, and said, almost in unison, "Okay, Sara. Why don't you go on up to bed? We'll finish cleaning up, visiting, etc, etc, etc."
Well, you know what I said? I looked at my watch, saw that it was only 2:32 pm, and said, "Oh no, guys. I'm not taking a nap until 2:45. I have plenty of time." God forbid I start a nap even one second earlier than planned, right? Of course, 2:45pm flew by, and before I knew it, it was 3pm, and I still wasn't napping.
And so it goes - just another day in the life of a determined, stubborn lupus patient. You know how it is - we try and assert ourselves against the disease. We make every attempt to show her who's boss by not giving in before we're good and ready. But when we do stuff like that...eek out the last few minutes of the oh-so-precious time we have before a nap...who loses? Lupus? I don't think so!
The only people who lose out are the lupites! Pushing our limits - whether it's skimping on rest, running too many errands, or taking on more than we can handle - is futile. The goal can't be to one-up the disease. The goal must be to stay one step ahead of the disease. And if that means napping a few minutes earlier or longer than planned, so be it. Say I get a few extra winks during that 15 minutes. At the end of the day - am I going to kick myself for missing out on those few minutes of clean up and visiting time? Or am I going to be armed and ready to have a rockin' good time that night at dinner?
Yeah. That's what I thought.
Now do what you need to do to arm yourself for a good, pain-free weekend...you deserve it!


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Revista Brasileira de Anestesiologia
Print version ISSN 0034-7094
On-line version ISSN 1806-907X
Rev. Bras. Anestesiol. vol.56 no.4 Campinas Set./Aug. 2006
Comparison of the hemodynamic effects in acute intoxication with racemic bupivacaine and with 50% enantiomeric excess mixture (S75-R25). An experimental study in dogs*
Comparación entre los Efectos Hemodinámicos de la Intoxicación Aguda con Bupivacaína Racémica y la Mezcla con Exceso Enatiomérico de 50% (S75-R25). Estudio Experimental en Perros
Artur Udelsmann, TSAI; Derli Conceição Munhoz, TSAII; William Adalberto SilvaIII; Ana Cristina de MoraesIII; Giancarlo MarcondesIV
Doutor do Departamento de Anestesiologia FCM/UNICAMP
IIProfessora Doutora do Serviço de Anestesiologia do HC-UNICAMP
IIIBiólogo do Núcleo de Medicina e Cirurgia Experimental
da FCM/UNICAMP
IVPós-graduando do Departamento de Cirurgia da FCM/UNICAMP
OBJECTIVES: Racemic bupivacaine has been widely used in locoregional anesthesia
due to the quality and duration of its anesthetic action. However, its cardiovascular
toxicity has worried anesthesiologists for a long time, and new options have
been sought. One of them is the use of its levorotatory isomer that, due to
a lesser affinity for the sodium channel receptors in the cardiac cell, would
be less toxic. The presentation containing 75% of the levorotatory isomer and
25% of the dextrorotatory isomer, named 50% enantiomeric excess mixture (S75-R25),
is available in our country. The objective of this study was to compare the
hemodynamic effects of the acute intoxication with racemic bupivacaine and with
the S75-R25 mixture in animals.
METHODS: Forty-four dogs were anesthetized with pentobarbital, intubated
and placed on mechanical ventilation. Hemodynamic monitorization was accomplished
with a Swan-Ganz catheter and intra-arterial blood pressure measurements. After
a period of rest, they were randomly and blindly divided in two groups, according
to the intoxication with either agent at a dose of 5 mg.Kg-1. Hemodynamic
data were collected during 30 minutes and analyzed statically to allow for the
comparison of both agents.
RESULTS: The mixture S75-R25 had more hemodynamic repercussions causing,
especially, a significant reduction of the mean arterial pressure, cardiac index,
and the left ventricle work index.
CONCLUSIONS: These results contradict those found in human beings regarding
the pure levorotatory isomer, but confirm recent animal studies. One must be
very careful when extrapolating animal data to human beings. Further studies
involving larger samples and more homogeneous groups are necessary.
Key Words: ANESTHETICS, local: racemic, bupivacaine, enantiomeric excess mixture; ANIMALS: dogs; CARDIOVASCULAR SYSTEM: hemodynamics alterations; COMPLICATIONS: sistemic toxicity; HEMODYNAMIC: intoxication effects.
Y OBJETIVOS: La bupivacaína racémica ha sido ampliamente utilizada
en bloqueos locorregionales por la calidad y duración de la anestesia
proporcionada. Su toxicidad cardiovascular, sin embargo ya hace mucho tiempo
preocupa a los anestesiólogos y nuevas opciones han sido buscadas. Una
de ellas es la utilización de su isómero levógiro que por
una menor afinidad con los receptores de los canales de sodio de la célula
cardiaca que sería menos cardiotóxico. En nuestro medio existe
la presentación que contiene un 75% del isómero levógiro
y 25% del isómero dextrógiro, denominada mezcla con exceso enantiomérico
de 50% (S75-R25). El objetivo de este estudio fue comparar en animales los efectos
hemodinámicos de la intoxicación aguda con bupivacaína
racémica y con la mezcla S75-R25.
MÉTODO: Cuarenta y cuatro perros fueron anestesiados con pentobarbital,
entubados y ventilados mecánicamente, siendo en seguida instalada la
monitorización hemodinámica con catéter de Swan-Ganz y
presión invasiva. Después del período de reposo fueron
divididos aleatoriamente en dos grupos de estudio encubierto, según la
intoxicación con uno u otro agente en la dosis de 5 mg.kg-1.
Los resultados hemodinámicos se recolectaron durante 30 minutos, tratados
estadísticamente permitiendo la comparación de la acción
de los dos agentes.
RESULTADOS: La mezcla S75-R25 causó mayores repercusiones hemodinámicas,
particularmente, con importante disminución de la presión arterial
promedio, del índice cardiaco y del índice de trabajo del ventrículo
CONCLUSIONES: Esos resultados se contraponen con los encontrados en humanos,
cuando se utiliza el isómero levógiro puro, pero están
de acuerdo con estudios recientes en animales. Rebasar datos obtenidos en animales
para seres humanos exige mucha cautela. Nuevos estudios se hacen necesarios
en muestras más abarcadoras y en grupos más homogéneos.
Epidural anesthesia is widely used in a number of surgical and obstetric procedures. High doses of local anesthetics are normally used with this technique, carrying the risk of toxic reactions, especially regarding the central nervous system, with the accidental intravenous injection. Due to its long action, bupivacaine is one of the local anesthetics used more frequently in this technique1,2. However, since Albright3 published a report on the severe cardiovascular effects of the intoxication with this drug, laboratory researches have been aimed at synthesizing new long lasting and less toxic local anesthetics. Even though bupivacaine is synthesized in the form of its two isomers, dextro- and levorotatory4, until recently only its racemic formulation, containing equal amounts of both isomers, was commercially available. However, it is common knowledge, since 1972, that its levorotatory isomer is less toxic5,6. Recently, studies with the levorotatory isomer, called levobupivacaine, in animal models showed that its lethal dose is 1.3 to 1.6 times greater than that of the racemic presentation7. In human beings, levobupivacaine would have a less pronounced negative inotropic effect and would cause a smaller lengthening of the PR and QT intervals in the EKG, which characterizes the intoxication of the racemic formulation. The pharmaceutical industry in Brazil manufactures a product containing 75% of the levorotatory isomer and 25% of the dextrorotatory isomer, known as 50% enantiomeric excess (S75-R25). Since this form is available only in our country, it was interesting to investigate the hemodynamic impact in the case of an accidental intoxication.
The objective of this study was to compare, in animals, the hemodynamic effects of the acute intoxication with racemic bupivacaine and with 50% enantiomeric excess (S75-R25).
After approval by UNICAMP's Ethical Committee on Animal Experiments, we conducted a study with 44 mongrel dogs, weighing from 15 to 30 kg, of both genders, healthy, supplied by UNICAMP's vivarium, that were submitted to the following protocol:
1. | Dogs were fasted the day before the study, with free access to water; |
2. | On the morning of the experiment, the animals were weighed and, after establishment of a venous access in one of its fore-foot, anesthesia was induced with 3% sodium pentobarbital (30 mg.kg-1)9; |
3. | The animal was then intubated and submitted to controlled ventilation with a pneumatic ventilator with partial rebreathing and CO2 absorber system, with a tidal volume of 15 mL.kg-1 and a respiratory frequency capable of maintaining a PETCO2 between 32 and 34 mmHg. An additional flow of O2 (1 l.min-1) was added and the hemoglobin O2 saturation was measured by a sensor placed in the animal's tongue with the objective of maintaining a value above 97%; |
4. | The ECG was monitored; |
5. | A continuous infusion of pentobarbital (5 mg.kg-1.h-1) was administered to maintain the anesthesia; |
6. | Local anesthesia with 5 mL 1% lidocaine without vasoconstrictor was applied in the inner aspect of one of the thighs of the animal for the catheterization of the femoral artery and monitoring of the mean arterial pressure (MAP). Afterwards, using the same incision, the femoral vein was dissected and a 7-French Swan-Ganz catheter was introduced. The catheter was placed in a branch of one of the pulmonary arteries. The placement was confirmed by the morphological aspect of the pressure wave on the multi-parametric Engstrom AS/3 monitor. This catheter provided the hemodynamic parameters: cardiac index (CI), hear rate (HR), central venous pressure (CVP), pulmonary capillary wedge pressure (PCWP), mean pulmonary artery pressure (MPAP), systemic vascular resistance index (SVRI), pulmonary vascular resistance index (PVRI), left ventricle work index (LVWI), left ventricle systolic work index (LVSWI), right ventricle systolic work index (RVSWI) and the systolic volume index (SVI). During this first step, a blood sample was drawn to determine the animals' hematocrit and hemoglobin values; |
7. | The animal's body surface area, expressed in m2, was calculated using the classic formula found in literature10: S = (10.1 x 2/3 weight in grams)/104, introducing it in the monitor to calculate the body's indexes; |
8. | After a 30-minute period of stabilization and rest, the first series of hemodynamic measurements was performed (M1); |
9. | The animals were randomly and blindly divided in 2 groups, called bupivacaine group (BG) and 50% enantiomeric excess bupivacaine group (EG). Bupivacaine or the S75-R25 mixture was administered by the intravenous route, at the maximal toxic non-lethal dose of 5 mg.kg-1 11. |
Hemodynamic measurements were taken at 1, 5, 10, 15, 20, and 30 minutes (M2 to M7, respectively) after intoxication. At the end of the experiment the animal was sacrificed, while still under anesthesia, with an intravenous injection of 10 mL of 19.1% potassium chloride.
The results of the different variables underwent statistical analysis using the Chi-square and, when necessary, Fisher's Exact test. The Mann-Whitney test was used to compare the distribution of continual variables measured in a single moment, and the analysis of variance (ANOVA) was used for the variables measured at different times. A level of 5%, i.e., p £ 0.05 was considered statistically significant; results between 5% and 10% were considered a tendency.
Table I presents the distribution of weight, body surface area, hematocrit, hemoglobin, gender, and number of animals that died in each group. The groups were homogenous, except for gender distribution, since there were more females in the BG. There were no differences between the groups at rest regarding the hemodynamic parameters measured.
After the intoxication, there was a reduction of the cardiac index in both groups (Figure 1), which was statistically significant in the EG (p = 0.0416). The values remained lower than M1 until the end of the experiment.
The MAP was significantly reduced in both groups in M2; however, this reduction was more pronounced in EG (p = 0.0389), and this difference remained until M5. In BG the pressure remained reduced form M2 to M4, recovering in M5. In EG this recovery occurred only in M7 (p = 0.0152) (Figure 2). The HR did not show differences between both groups, but the levels in M1 were different from the other levels measured until M7 (p = 0.0001) (Figure 3).
The CVP did not show differences between both groups, but from M2 the values were different from those obtained initially (p = 0.001) (Figure 4). The behavior of the PCWP was similar; there were no differences between both groups, but the levels after intoxication were different from those obtained initially (p = 0.0001) (Figure 5).
There were no differences between the groups regarding the mean pulmonary artery pressure, but the values found after the intoxication were different from those at rest (p = 0.0001) (Figure 6)
The systemic vascular resistance index did not differ between both groups and among the different times up to M4. From this moment the values were higher than the ones at rest in both groups (p = 0.0001) (Figure 7).
The pulmonary vascular resistance index also did not show any differences between both groups, but it increased in M2, just after the intoxication (p = 0.003 and p = 0.004) in both groups (Figure 8).
The left ventricle systolic work index decreased significantly in both groups after intoxication, but this reduction was more important in EG than in BG (p = 0.0451). This difference was maintained until M5. All the measurements obtained in each group after the intoxication were different from those obtained at rest (p = 0.0001) (Figure 9).
The right ventricle systolic work index showed a tendency to decrease in M2 (p = 0.0595 and p = 0.0505) without any differences between both groups, but the measurements obtained from M2 through M7 were different from the initial ones (p = 0.0001) (Figure 10).
The systolic volume index also decreased significantly in M2 (p = 0.0001), but there were no differences between both groups; those values remained below the initial levels until the end of the experiment (Figure 11).
The accidental intravenous injection of local anesthetics has been a constant source of concern for anesthesiologists. Racemic bupivacaine was widely used for several years until reports about its nervous and cardiovascular toxicity were published. From then on the research for new local anesthetics increased. One of the first discoveries in this area, which was introduced in the clinical practice in a relatively short period of time, was the levorotatory isomers, which are less toxic; soon, levobupivacaine and ropivacaine, agents containing only the levorotatory isomer, were commercially available, and since then several authors have demonstrated that they are less toxic. However, the motor blockade caused by levobupivacaine is weaker than that of its racemic form7,12-15. For this reason, there would be a theoretical advantage of adding a small amount of its dextrotatory isomer to balance its action14 while still guaranteeing a product that is less toxic. The Brazilian pharmaceutical industry has synthesized such a drug, which has been widely used and known for being less toxic. Since this presentation is available only in our country, its cardiotoxicity was evaluated in dogs. The isomer S(-) is less cardiotoxic because of its reduced affinity, compared to the isomer R(+)16, for blocking the sodium channels of myocardial cells, which was demonstrated in laboratory animals. Such data, however, must be looked at with some reservation before being extrapolated to human beings. According to the data gathered by other authors comparing the effects of levobupivacaine, racemic bupivacaine, and ropivacaine in dogs, who have found a similar degree of toxicity17, or even a higher toxicity in the former drug18,19, the results of this study showed a greater hemodynamic effect of the enantiomeric excess presentation than racemic bupivacaine in cases of acute intoxication similar to what happens with an accidental intravenous injection when applying a locoregional anesthesia. These results are very clear from the significant reduction in mean arterial pressure, cardiac index, and left ventricle systolic work index; the mean of these results in EG were considerably lower, and remained so almost until the end of the experiment, showing a greater impact of this preparation on the cardiovascular system. Four animals in the group intoxicated with the 50% enantiomeric excess presentation died, but this was not statistically significant, and it probably needs a larger sample for a definitive conclusion. The results are contrary to what is seen in human beings treated with levobupivacaine, which has a lesser impact on the cardiovascular system. However, these results in animals should be viewed cautiously; one should be careful when extrapolating these results to human beings, but it should stimulate more studies involving this drug. The accidents caused by locoregional anesthesia, with the intravascular injection of high doses and toxic reactions, have been decreasing drastically for the last 30 years, from 0.2% to 0.01%, but peripheral nerve blockades still account for the majority of cases (7.5 per 10,000)20. Clinical and pharmacological efforts should continue to be made to decrease those accidents and their repercussions to a level compatible to the current scientific knowledge. Every effort should be made to reduce the morbidity and mortality related to anesthesia.
01. Groban L, Deal DD, Vernon JC et al Cardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogs. Anesth Analg, 2001;92:37-43. [ Links ]
02. Chang DH, Ladd LA, Copeland S et al Direct cardiac effects of intracoronary bupivacaine, levobupivaciane and ropivacaine in the sheep. Br J Pharmacol, 2001;132:649-658. [ Links ]
03. Albright GA Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology, 1979;51:285-287. [ Links ]
04. Ohmura S, Kawada M, Ohta T et al Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine, or ropivacaine-infused rats. Anesth Analg, 2001;93:743-748. [ Links ]
05. Aberg G Toxicological and local anaesthetic effects of optically active isomers of two local anaesthetic compounds. Acta Pharmacol Toxicol, 1972;31:273-286. [ Links ]
06. Luduena FP, Bogado EF, Tullar BF Optical isomers of mepivacaine and bupivacaine. Arch Int Pharmacodyn, 1972; 200:359-369. [ Links ]
07. Foster RH, Markham A Levobupivacaine: a review of its pharmacology and use as a local anaesthetic. Drugs, 2000; 59:551-579. [ Links ]
08. Bardsley H, Gristwood R, Baker H et al A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers. Br J Clin Pharmacol, 1998;46:245-249. [ Links ]
09. Harvey RC, Paddleford RR, Popilskis SJ et al Anesthesia and Analgesia in Dogs, Cats and Ferrets, em: Kohn DF, Wixson SK, White WJ et al Anesthesia and Analgesia in Laboratory Animals, 1st Ed, New York, Academic Press,1997;257-273. [ Links ]
10. Ettinger SJ Textbook of Veterinary Internal Medicine, 1st Ed, Philadelphia, WB Saunders, 1975;146. [ Links ]
11. Skarda RT Local and Regional Anesthetic and Analgesic Techniques: Dogs, em: Thurmon JC, Tranquilli WJ, Benson GJ Veterinary Anesthesia, 3rd ed, Philadelphia, Willians & Wilkins, 1996;426-447. [ Links ]
12. Delfino J, Vale NB Bupivacaína levógira a 0,5% pura versus mistura enantiomérica de bupivacaína (S75-R25) a 0,5% em anestesia peridural para cirurgia de varizes. Rev Bras Anestesiol, 2001;51:474-481. [ Links ]
13. Tanaka PP, Souza RO, Salvalaggio MFO et al Estudo comparativo entre bupivacaína a 0,5% e a mistura enantiomérica de bupivacaína (S75-R25) a 05% em anestesia peridural em pacientes submetidos a cirurgia ortopédica de membros inferiores. Rev Bras Anestesiol, 2003;53:331-337. [ Links ]
14. Gonçalves RF, Lauretti GR, Mattos Al Estudo comparativo entre bupivacaína a 0,5% e mistura enantiomérica de bupivacaína (S75-R25) em anestesia peridural. Rev Bras Anestesiol, 2003;53:169-176. [ Links ]
15. Lacassie HJ, Columb MO The relative motor blocking potencies of bupivacaine and levobupivacaine in labor. Anesth Analg, 2003;97:1509-1513. [ Links ]
16. Valenzuela C, Snyders DJ, Bennett PB et al Stereosectivite block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes. Circulation, 1995;92:3014-3024. [ Links ]
17. Royse CF, Royse AG The myocardial and vascular effects of bupivacaine, levobupivacaine, and ropivacaine using pressure volume loops. Anesth Analg, 2005;101:679-687. [ Links ]
18. Masuda R, Takeda S, Yoshii S et al Levobupivacaine exerts the most detrimental effect on the cardiovascular system among enantiomers of bupivacaína in anesthetized dogs. Anesthesiology, 2004;101:(Suppl):A652. [ Links ]
19. Jung CW, Lee KH, Choe YS et al Comparison of resuscitative effect of insulin between bupivacaine and levobupivacaína induced cardiovascular collapse in dogs. Anesthesiology, 2004;101:(Suppl):A649. [ Links ]
20. Cox B, Durieux ME, Marcus MA Toxicity of local anaesthetics. Best Pract Res Clin Anaesthesiol, 2003;17:111-136. [ Links ]
Correspondence to:
Dr. Artur Udelsmann
Av. Prof. Atílio Martini, 213
13083-830 Campinas, SP
E-mail: firstname.lastname@example.com
Submitted for publication
7 de novembro de 2005
Accepted for publication 7 de abril de 2006
* Received from Laboratório de Anestesia Experimental do Núcleo de Medicina e Cirurgia Experimental da Faculdade de Ciências Médicas da UNICAMP, Campinas, SP.


text:
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BACKGROUND: In recent years, the number of High Throughput Screening (HTS) assays deposited in PubChem has grown quickly. As a result, the volume of both the structured information (i.e. molecular structure, bioactivities) and the unstructured information (such as descriptions of bioassay experiments), has been increasing exponentially. As a result, it has become even more demanding and challenging to efficiently assemble the bioactivity data by mining the huge amount of information to identify and interpret the relationships among the diversified bioassay experiments. In this work, we propose a text-mining based approach for bioassay neighboring analysis from the unstructured text descriptions contained in the PubChem BioAssay database. RESULTS: The neighboring analysis is achieved by evaluating the cosine scores of each bioassay pair and fraction of overlaps among the human-curated neighbors. Our results from the cosine score distribution analysis and assay neighbor clustering analysis on all PubChem bioassays suggest that strong correlations among the bioassays can be identified from their conceptual relevance. A comparison with other existing assay neighboring methods suggests that the text-mining based bioassay neighboring approach provides meaningful linkages among the PubChem bioassays, and complements the existing methods by identifying additional relationships among the bioassay entries. CONCLUSIONS: The text-mining based bioassay neighboring analysis is efficient for correlating bioassays and studying different aspects of a biological process, which are otherwise difficult to achieve by existing neighboring procedures due to the lack of specific annotations and structured information. It is suggested that the text-mining based bioassay neighboring analysis can be used as a standalone or as a complementary tool for the PubChem bioassay neighboring process to enable efficient integration of assay results and generate hypotheses for the discovery of bioactivities of the tested reagents.
Pubmed ID: 21059237 RIS Download
Mesh terms: Biological Assay | Data Mining | Databases, Factual | High-Throughput Screening Assays
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.


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Walking into the 19 Christmas party last night and who should cross my path but Will Young - on TV he always looks super cute but in real life he's more handsome than cute. What a fab party - fizz and amazing food all evening - including a non-stop sushi bar. Tons of gorgeous bright young things around – eek - who could compete with the long legs and tiny skirts (obviously on trend this season). Honestly wasn't sure where hubby could look without his eyes falling on the endless legs of some super model - I do get annoyed when it's obvious where his eyes were landing - at least men should try and hide it when they're surrounded by beautiful women! But on the whole I've got to say he's pretty darn good at hiding the fact that he's noticed something like loads of models swishing around.
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As we left Rachel Stevens was arriving and she's another pint-sized poppet - all these tiny celebs - must be something about being tiny that makes you want to prove yourself - some of my most dynanmic pals are petite dynamos - wish I had their energy!
TODAY'S THOUGHT: which brings me to an acquaintance that I think (after a lot of thought - more angst really) I'm going to have to drop as an acquaintance because she's always trying to prove something - conversations are always one-way revolving around her latest accomplishment, her latest success, her latest rise/perk/etc. There's no such thing as 'mucking up' in her world and I've always thought that people who are too perfect are usually hiding deep insecurities. You might think it's harsh but if she was a real pal I'd try and encourage her to relax and let up a little. But she's not and it's not my business to do so.
Speaking of perfect - or imperfection I should say - I didn't realise that the person one of my children has started going out with in the last few months, was in our kitchen yesterday afternoon when I ran in with a load of wash to throw in the machine - my hair a fright and a face mask plastered on my face, wearing a dog-eared old dressing gown worthy of Nora Batty. Talk about being caught out - how you often look when you're charging around between household chores and trying to get ready for an evening out - but don't want to look. Oh well, it looks like they're getting serious, so this new person's just going to have to get used to what I'm like....a slob much of the time!
Well, will Rage Against The Machine have beaten Simon Cowell's schmaltzy song for Joe McElderry on tonight's Radio 1 Chart show? Simon Cowell has a massive cheek to assume that he owns that No. 1 post-X Factor slot - and as for choosing that awful song for poor Joe - his eye was really off the ball –my heart goes out to Joe!
Tonight we're off to the Hammersmith Apollo to see the wonderful Robin Ince host 'Nine Lessons and Carols for the Godless' - last year was a sell-out and this one might end up too, with lots of top comedy names in the line-up including Al Murray.
Keep warm this evening, Pam X
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My latest sex guide's out - I've gone through thousands of questions people ask me about sex - from why they don't feel desire to how to handle a partner's kinky fetish. Here are the answers plus loads of tricks and techniques. Enjoy!
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text:
The Last of the Mohicans
by James Fenimore Cooper- Overview
- Editorial Reviews
- Product Details
- Related Subjects
- Read an Excerpt
- What People Are Saying
- Meet the author
Editorial Reviews
Nearly 200 years on, the tale of The Last of the Mohicans is still a part of the American consciousness.
Kerrie Mills
- Joseph Conrad
Product Details
- 9781847023018
- Publisher:
- Echo Library
- Publication date:
- 05/08/2006
- Pages:
- 468
- Product dimensions:
- 8.25(w) x 11.00(h) x 0.94(d)
Read an Excerpt
"Mine ear is open, and my heart prepared:
The worst is worldly loss thou canst unfold:
Say, is my kingdom lost?"
IT was a feature peculiar to the colonial wars of North America, that the toils and dangers of the wilderness were to be encountered before the adverse hosts could meet. A wide and apparently an impervious boundary of forests severed the possessions of the hostile provinces of France and England. The hardy colonist, and the trained European who fought at his side, frequently expended months in struggling against the rapids of the streams, or in effecting the rugged passes of the mountains, in quest of an opportunity to exhibit their courage in a more martial conflict. But, emulating the patience and self-denial of the practised native warriors, they learned to overcome every difficulty; and it would seem that, in time, there was no recess of the woods so dark, nor any secret place so lovely, that it might claim exemption from the inroads of those who had pledged their blood to satiate their vengeance, or to uphold the cold and selfish policy of the distant monarchs of Europe.
Perhaps no district throughout the wide extent of the intermediate frontiers can furnish a livelier picture of the cruelty and fierceness of the savage warfare of those periods than the country which lies between the head waters of the Hudson and the adjacent lakes.
The facilities which nature had there offered to the march of the combatants were too obvious to be neglected. The lengthened sheet of the Champlain stretched from the frontiers of Canada, deep within the borders of the neighboring province of New York, forming a natural passage across half the distance that the French were compelled to master in order to strike their enemies. Near its southern termination, it received the contributions of another lake, whose waters were so limpid as to have been exclusively selected by the Jesuit missionaries to perform the typical purification of baptism, and to obtain for it the title of lake "du Saint Sacrement." The less zealous English thought they conferred a sufficient honor on its unsullied fountains, when they bestowed the name of their reigning prince, the second of the house of Hanover. The two united to rob the untutored possessors of its wooded scenery of their native right to perpetuate its original appellation of "Horican."
Winding its way among countless islands, and imbedded in mountains, the "holy lake" extended a dozen leagues still farther to the south. With the high plain that there interposed itself to the further passage of the water, commenced a portage of as many miles, which conducted the adventurer to the banks of the Hudson, at a point where, with the usual obstructions of the rapids, or rifts, as they were then termed in the language of the country, the river became navigable to the tide.
While, in the pursuit of their daring plans of annoyance, the restless enterprise of the French even attempted the distant and difficult gorges of the Alleghany, it may easily be imagined that their proverbial acuteness would not overlook the natural advantages of the district we have just described. It became, emphatically, the bloody arena, in which most of the battles for the mastery of the colonies were contested. Forts were erected at the different points that commanded the facilities of the route, and were taken and retaken, rased and rebuilt, as victory alighted on the hostile banners. While the husbandman shrank back from the dangerous passes, within the safer boundaries of the more ancient settlements, armies larger than those that had often disposed of the sceptres of the mother countries, were seen to bury themselves in these forests, whence they rarely returned but in skeleton bands, that were haggard with care, or dejected by defeat. Though the arts of peace were unknown to this fatal region, its forests were alive with men; its shades and glens rang with the sounds of martial music, and the echoes of its mountains threw back the laugh, or repeated the wanton cry, of many a gallant and reckless youth, as he hurried by them, in the noontide of his spirits, to slumber in a long night of forgetfulness.
It was in this scene of strife and bloodshed that the incidents we shall attempt to relate occurred, during the third year of the war which England and France last waged for the possession of a country that neither was destined to retain.
The imbecility of her military leaders abroad, and the fatal want of energy in her councils at home, had lowered the character of Great Britain from the proud elevation on which it had been placed, by the talents and enterprise of her former warriors and statesmen. No longer dreaded by her enemies, her servants were fast losing the confidence of self-respect. In this mortifying abasement, the colonists, though innocent of her imbecility, and too humble to be the agents of her blunders, were but the natural participators.
They had recently seen a chosen army from that country, which, reverencing as a mother, they had blindly believed invincible - an army led by a chief who had been selected from a crowd of trained warriors, for his rare military endowments, disgracefully routed by a handful of French and Indians, and only saved from annihilation by the coolness and spirit of a Virginian boy, whose riper fame has since diffused itself, with the steady influence of moral truth, to the uttermost confines of Christendom. A wide frontier had been laid naked by this unexpected disaster, and more substantial evils were preceded by a thousand fanciful and imaginary dangers. The alarmed colonists believed that the yells of the savages mingled with every fitful gust of wind that issued from the interminable forests of the west. The terrific character of their merciless enemies increased immeasurably the natural horrors of warfare. Numberless recent massacres were still vivid in their recollections; nor was there any ear in the provinces so deaf as not to have drunk in with avidity the narrative of some fearful tale of midnight murder, in which the natives of the forests were the principal and barbarous actors. As the credulous and excited traveller related the hazardous chances of the wilderness, the blood of the timid curdled with terror, and mothers cast anxious glances even at those children which slumbered within the security of the largest towns. In short, the magnifying influence of fear began to set at naught the calculations of reason, and to render those who should have remembered their manhood, the slaves of the basest of passions. Even the most confident and the stoutest hearts began to think the issue of the contest was becoming doubtful; and that abject class was hourly increasing in numbers, who thought they foresaw all the possessions of the English crown in America subdued by their Christian foes, or laid waste by the inroads of their relentless allies.
When, therefore, intelligence was received at the fort, which covered the southern termination of the portage between the Hudson and the lakes, that Montcalm had been seen moving up the Champlain, with an army "numerous as the leaves on the trees," its truth was admitted with more of the craven reluctance of fear than with the stern joy that a warrior should feel, in finding an enemy within reach of his blow. The news had been brought, towards the decline of a day in midsummer, by an Indian runner, who also bore an urgent request from Munro, the commander of a work on the shore of the "holy lake," for a speedy and powerful reinforcement. It has already been mentioned that the distance between these two posts was less than five leagues. The rude path, which originally formed their line of communication, had been widened for the passage of wagons; so that the distance which had been travelled by the son of the forest in two hours, might easily be effected by a detachment of troops, with their necessary baggage, between the rising and setting of a summer sun. The loyal servants of the British crown had given to one of these forest fastnesses the name of William Henry, and to the other that of Fort Edward; calling each after a favorite prince of the reigning family. The veteran Scotchman just named held the first, with a regiment of regulars and a few provincials; a force really by far too small to make head against the formidable power that Montcalm was leading to the foot of his earthen mounds. At the latter, however, lay General Webb, who commanded the armies of the king in the northern provinces, with a body of more than five thousand men. By uniting the several detachments of his command, this officer might have arrayed nearly double that number of combatants against the enterprising Frenchman, who had ventured so far from his reinforcements, with an army but little superior in numbers.
But under the influence of their degraded fortunes, both officers and men appeared better disposed to await the approach of their formidable antagonists, within their works, than to resist the progress of their march, by emulating the successful example of the French at Fort du Quesne, and striking a blow on their advance.
After the first surprise of the intelligence had a little abated, a rumor was spread through the entrenched camp, which stretched along the margin of the Hudson, forming a chain of outworks to the body of the fort itself, that a chosen detachment of fifteen hundred men was to depart, with the dawn, for William Henry, the post at the northern extremity of the portage. That which at first was only rumor, soon became certainty, as orders passed from the quarters of the commander-in-chief to the several corps he had selected for this service, to prepare for their speedy departure. All doubt as to the intention of Webb now vanished, and an hour or two of hurried footsteps and anxious faces succeeded. The novice in the military art flew from point to point, retarding his own preparations by the excess of his violent and somewhat distempered zeal; while the more practised veteran made his arrangements with a deliberation that scorned every appearance of haste; though his sober lineaments and anxious eye sufficiently betrayed that he had no very strong professional relish for the as yet untried and dreaded warfare of the wilderness. At length the sun set in a flood of glory, behind the distant western hills, and as darkness drew its veil around the secluded spot the sounds of preparation diminished; the last light finally disappeared from the log cabin of some officer; the trees cast their deeper shadows over the mounds and the rippling stream, and a silence soon pervaded the camp, as deep as that which reigned in the vast forest by which it was environed.
What People are Saying About This
"The Last of the Mohicans raises again the question of the efficacy of human effort to control irrational forces at work in individual men, races, and nations. The question has never been more pertinent than now." –James Franklin Beard
Meet the Author
The son of prominent federalist William Cooper the founder of the Cooperstown settlement James Fenimore Cooper was America's first true literary star. Extremely prolific, he wrote 32 novels, 12 works of nonfiction, a play, and dozens of pamphlets and articles. His ultimate achievement is known as "The Leatherstocking Tales," five rugged novels featuring Natty Bumppo.
Brief Biography
- Date of Birth:
- September 15, 1789
- Date of Death:
- September 14, 1851
- Place of Birth:
- Burlington, New Jersey
- Place of Death:
- Cooperstown, New York
- Education:
- Yale University (expelled in 1805)
Customer Reviews
Average Review:
Most Helpful Customer Reviews
Lest its importance be lost, let me praise at once the Barnes and Noble Classics edition of THE LAST OF THE MOHICANS for its bit more than one page long essay -- 431f-- after the end notes -- called 'INSPIRED BY THE LAST OF THE MOHICANS.' By Stephen Railton, 'INSPIRED' lists and describes notable cinema inspired by Cooper's masterpiece. They begin with D. W. Griffith's 1909 one reeler, LEATHER STOCKING and move along through the 1920 Maurice Tourneur version with Wallace Beery as the satanic Magua and 1924 and 1936 versions by director George B. Seitz, the last starring Randolph Scott 'in perhaps the performance of his career.' Michael Mann's Oscar- winning 1992 THE LAST OF THE MOHICANS is great fun but bears very little resemblance to Cooper's original. *** The last words of this great novel give a sense of what the point of the yarn is. They are solemn remarks by ancient chief Tamenund, well over a century old, whose name is also preserved as Tammany and in 'Tammany Hall.' He concludes thus the funeral rites for Cora and Uncas: 'It is enough,' he said. 'Go, children, of the Lenape, the anger of Manitou is not done. ... The pale-faces are masters of the earth, and the time of the red-men has not yet come again. The day has been too long. In the morning I saw the sons of Unamis [turtles, totem, i.e., of Delawares of the eastern seaboard] happy and strong and yet, before the night has come, have I lived to see the last warrior of the wise race of the Mohicans.' 'Ch XXXIII' *** This book is probably too leisurely for children or even college students who are not English majors. Read it for a sad meditation on why American Indians and European whites never found a way to live together as equals and form an entirely new North American civilization -- much as the Normans had done in Saxon England. Fenimore Cooper makes much of white prejudices against interracial marriages. That Scottish Cora could love and be loved by the last Mohican Indian, gorgeous young Uncas, was thinkable to Cooper's readers only because far back in time she had had a West Indian granddam of color. *** Cooper also notes that the massacre of surrendered troops of Fort William Henry by Indian allies of the French was the second such incident to blot the copy book of the Marquis de Montcalm. *** A final historical suggestion by Cooper is that the Indians could have made themselves as much junior partners of the colonials as the savage Highlanders of Scotland eventually became of Scottish lowlanders and the vastly more numerous English. But the Indians could not unite. They spent too much time killing and raiding other Indians to resist the all-conquering European whites. --- -OOO-
The Last of the Mohicans was an interesting and very detailed portrayal of a small group in the middle of the French and Indian War. I liked it a lot and would like to read more of James Fenimore Cooper¿s novels sometime. I know that many people enjoyed the movie, but to get the whole picture, you really need to read the book. The movie is great, I agree, but I just liked to book better (then again, when is it that you ever like a movie more than the book?). Though not my favourite classic, it is still an amazing book, very worthy of anyone¿s reading time.
Well, I must be the bearer of bad news here: the back cover of the Barnes & Noble Classics edition of this novel leads readers astray. It mentions "death-defying chases and teeth-clenching suspense," but let me tell you, there's nothing teeth-clenching about this book. I've never liked Cooper's writing, so I may come off as a little harsh, but the plot is average at best and even painfully predictable at times. Granted, plot isn't everything, but this novel does not possess many qualities that redeem the floundering plot. Cooper writes rather coldly, and his characters, with the possible exception of Hawk-eye, are extremely flat and even unlikable, which does not work well for this kind of story. I must give Cooper credit for his exquisite descriptions, especially of the vast frontier wilderness, but unfortunately for Cooper, description alone doesn't make a good book. I'd like to read The Last of the Mohicans again, just to make sure I didn't miss some revelation the first time around, but when the book cover is better than the story, you know something's wrong.
Twain was right about Fenimore....but i still need to read all the classics i blew off or didn't finish in HS
James Fenimore Cooper's novel, The last of the Mohincans, tells the story of the colonial scout Hawkeye, real name Natty Bumppo, with his 2 Indian companions Changachgook (his Mohican father) and his mohican brother Uncas. They stumble onto a party of British soldiers conducting 2 fair maidens (names Alice and Cora) traveling to their father Colonel Munro, who is the commander of the British Fort William Henry during the French and Indian War. They are being treacherously lead by a huron scout Magua who intends to hurt the 2 girls in order to get to their father the Colonel. I thought that The Last of the Mohicans was a very interesting piece of work. The book has a compelling story and great characters. Any one that is interested in historical fiction should read this book. The aouther tells this story in chronological order and in third person. He was very descriptive and precise in writing this novel. It is filled with action and adventure. It has a heart felt story with a sad, but meaningful conclusion that is poignant and well thought out. It gives you a sence of guilt to anyone that is from a British/ French heritage. It makes you realize what is the real goal of English or French society, putting risk on lives and ancient cultural heritage of the Native American people? Or have a few extra acres of land? I think that anyone who loves reading and have a plot that makes their mind work a little, would have the privelege of reading this book.
This Book took me a long time to finish. It is a good story and should be read. But it is really slow going, and i found that parts of it are boring. if you have trouble getting through books you shouldnt read it.
Huge fan of the movie but I must say it was hard to finish this book. I tried to put myself in the mindset of the time it was written, but the book was simply just too boring. Explanations and events in the story were excruciatingly too drawn out and the dialogue was ridiculous in a lot of parts.
This book contains The Last Of The Mohicans and The Prarie and technically I only finished The Last Of The Mohicans, but it's a novel in itself so it counts. Anyhoo, I loved the book. Once you get past the nineteenth century prose, it's really a great story. It's a story of adventure and friendship, loyalty and revenge, of newly made bonds and loss.
This book is a hard read and quite frankly I'm shocked that it took me just under a week to get through it. The language--the prose is not for everyone. But I can see why this book has remained a favorite classic for well over a hundred years. I'm looking forward to tackling the rest of the Leatherstocking Tales...at a later date.
For those who are fans of the Michael Mann movie version of this story(of which I am one), this book is nothing like the film. Though it will always be on my top ten list of favorite movies, having read the book, I'm a bit perturbed at the changes Mann and the script writers made to the story. Clearly we all know the book is always better than the movie, and that some things must be omitted due to the timing and flow of a film. However, there were some changes that I think were unnecessary and I would like to have seen them on film. They really downplayed Chingachgook and Uncas' roles in the adventure, their relationship with each other and Hawkeye, and their status among the Indian people. Also they downplayed Duncan who wasn't really a douche in the novel as he was in the film. The love interests were portrayed all wrong, and frankly the movie was more of a love story than that of an adventure. Whereas the novel was move adventure and only vague mentions of romance. I've never seen any of the other versions of the film and have to wonder if they were more true to the novel. I suppose I mentioned this to warn anyone against reading this hoping it'll be a more fleshed-out version of the film. While the overall story basically remains the same, the journey, battles, rescues and some deaths are completely different.
But to those who are lovers over books, classics, or true stories of adventure and virtue, this is a must-read!
Im here
She goes to a table to sit. Her blue crystalized dress gets in her way.
His mask was ovalish and white, that of a wickedly smiling face. He grips two bottle of absinthe in both of his hands.
Walks in wearing a short blue dress
*walks up* id please.
'the republic' all res. For every ad posted there, two will be posted here
Walked over "whats happening" he muttered passing by
"Hi." She only chuckled, ruffling Azure's hair in an friendly gesture after he was sat down. "You're an idiot, Fox."
How about 'walt whitney'.
Is gone
Lickedher pups.
Ŷ ⁒ q Ḻ ␱ ⏎ ▤ ¦
Mewed loadly even though he was born awhile ago the fluffy fur didnt hide how sickly he kit looked its stoumach growled ladly needing some milk to feed on
Son of flame, Daughter of earth,<br>
A new pack has risen.<br>
Their leader,<br>
Kindles the fire of hatred against you.<p>
Darkness will fall upon the land.<br>
Violence will wear the crown.<br>
The war is near at hand.<p>
Son of flame<br>
Guide your pack with your strength and understanding.<br>
Daughter of earth,<br>
Unite the pack with your kindness and wisdom.<p>
That you may not diminish, but shall open a golden age.


text:
"The name 'Camelback Ranch' inspires the pioneering spirit of the Dodgers' original move west in 1958 and with our relocation this spring to Arizona, that move is now complete," said McCourt. "We believe this facility will be the best in all of Major League Baseball and will provide our team with an unparalleled place to prepare year-round for championship-caliber baseball."
"Camelback Ranch in Glendale soon will be known as the crown-jewel of the Cactus League," said Reinsdorf. "Starting this spring, baseball fans will be able to enjoy a world-class complex that features the Cactus League's largest ballpark with state-of-the-art amenities and one of the most scenic environments in all of sports and entertainment."
The 141-acre site is located on Camelback Road just west of the Loop 101. The first-rate baseball facility includes more than 118,000 square feet of Major and Minor League clubhouse space, 13 full baseball fields, and three half-fields. The site will feature picturesque walking trails, landscaped grounds, and an orange grove. There will also be two ponds and a fully-stocked lake between the Dodgers and White Sox facilities.
The shared stadium, which will be the focal point of the complex, is the largest in the Cactus League with a capacity of 13,000 which includes 3,000 lawn seats, 12 luxury suites, a party deck, and a unique center field rotunda entrance. Fans will enjoy the ballpark's modern amenities and design as well as dramatic mountain views from within the park that will create one of the most inviting Spring Training atmospheres in all of baseball.
"It is my sincere hope that generations of families will create lifelong memories at Camelback Ranch," said Dodger President Jamie McCourt. "This idyllic setting - only five hours by car and a one-hour flight from Los Angeles - could not come at a more perfect time for Dodger fans, many of whom have waited a long time to take part in the Spring Training experience."
"Many former Chicagoans now call the Valley home," said Reinsdorf. "That large contingent of people, along with the thousands of current Chicagoans who travel to the Phoenix area during the winter months, now will have the opportunity to enjoy White Sox baseball in an incomparable sports and entertainment facility."
In addition to serving as the Spring Training home of the White Sox and Dodgers, the campus will become the home for all Dodger minor league operations throughout the year, including the team's Arizona League entry and Fall Instructional League team. The White Sox also will use Camelback Ranch in Glendale as the home for their Fall Instructional League.
Camelback Ranch will become a multi-use facility, available to host concerts, sporting events, and corporate outings, in addition to Spring Training baseball.
The 2009 Spring Training schedules will be released shortly for each team, while the joint venture offers six different season ticket options: Home Plate Club, Dugout Field Box, Baseline Field Box, Premium Infield Box, Infield Box, and Baseline Reserved, along with day-of-game Lawn seating. Fans interested in purchasing season tickets should call (623) 877-8585.
Renderings and a recent aerial photo of Camelback Ranch are attached, while updated photos of Camelback Ranch can be seen here: http://mlb.mlb.com/la/photogallery/year_2008/month_11/day_11/cf3674479.html


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In a recent feature on Sigur Ros' upcoming live CD/DVD release, Inni, the Wall Street Journal dropped a pretty substantial note regarding the Icelandic band's next move. Apparently they have been back in the studio working on a new full-length album that's set to drop in spring 2012.
Yeah, the follow-up to Með suð í eyrum við spilum endalaust is due out that soon. And according to the WSJ interview, the guys have moved into some different musical territory. They noted that it's "introverted," "floaty and minimal," and "[a]n ambient album." Can't wait to hear it. Peep a snippet of the interview below. Inni drops Nov. 15.
The band went straight to work at their studio, set in a space once occupied by a swimming pool. They weren't satisfied with their initial sessions. "We were recycling," Mr. Birgisson said. But the quartet soon found its new focus.
The band's next album is scheduled for release in the spring. Based on excerpts presented by Mr. Sveinsson, the new music promises to be as exceptional as the best of the band's catalog. Mr. Hólm called it "introverted," while Mr. Birgisson said it was "floaty and minimal." "An ambient album" was how Mr. Dýrason described it, with "a slow takeoff toward something." For a visitor who heard a preliminary recording in which Mr. Birgisson's falsetto was surrounded by rich choral voices and what sounded like a pipe organ, the music was thrilling.
R. Kelly - R. Kelly Shares The Absurd Cover For His Autobiography 'Soulacoaster' | Frank Black Frank Black Starts Record Label |


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Eco Drinkware
Reusable Water Bottles Display Your Marketing Message
It seems like everyplace you go you see people carrying around disposable or reusable water bottles. If you can get a reusable water bottle branded with your company's marketing message into your customer's hands they will carry it and essentially display a billboard with your branding statement. This kind of exposure can do wonders for your company and through repeated viewing your brand recognition will grow along with your customer base.
Reusable Products Live Up to Your Green Standards
When you market your brand with a reusable product you are making a statement about sustainability. Reusable water bottles eliminate the need for disposable water bottles which can take up space in landfills and do not safely break down. If your customers fill their reusable bottle with tap water they can also save money since the cost of bottled water really adds up. Explain these perks to your customers – let them know that you are making an effort to reduce the amount of plastic in our landfills to help the planet and that your custom branded water bottle can also help their bottom line. Customers who aspire to be green will be on board with what you are trying to do, and members of your demographic who are not as concerned about living an eco-friendly lifestyle will still appreciate the usefulness and convenience of your customized promotional water bottle, so either way your brand will get exposure


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By December of 2005 it was evident that the Republican Right Wing was getting ready to create a new "crisis" afflicting our country. In that light, I wrote the following article "Right Wing Republican bait & switch? Not this time".Given
• that during the majority of the Bush administration, the Republicans controlled the Executive & Legislature (both Senate & House),
• that 9-11 occurred 5 years back with no substantive improvement in border security in said period (neither the Canadian or Mexican border),
•that the largest border of all, our coastline and ports, remained porous
It is laughable that the Right Wing would have the mitigated gall to use this issue as a wedge in an attempt to corner liberals into the trap of being against the population. Their idea is to plant stories throughout the mass media about the strain illegal aliens are putting on society at large as well as the security implications. After this false impression has metastasized, they then challenge Liberals as being soft on illegal immigration and security.
In watching the discourse in the mass media and in the blogosphere, I fail to see an emphatic response specifically hammering every Right Winger that brings up the immigration issue with their specific failure, being the party in power, to submit or effect legislation to protect the border. This one issue packaged appropriately can show their incompetence and hypocrisy.
The reality is that the immigration issue is a complex issue that is not easily explained in sound bytes (the preferred language of communication perfected by the Right Wing). As such, it is best not to be forced to address issues of citizenship but hammer on border security as well as homeland security. We do not need to get wordy or nuanced on this issue. We should make the immigration issue our issue.
Powered by Sidelines


text:
Three weeks ago, Maryland was riding a three-game winning streak into Pittsburgh before being outmuscled and outplayed in a 20-point loss at Petersen Events Center. The situation was not as dire then as it is now, as the Terrapins come off a crushing road loss to an undermanned NC State team.
Can Maryland get a much-needed resume-building win on Saturday evening? Preview the game below.
Pittsburgh's Lamar Patterson vs. Maryland's Nick Faust
Faust is often tabbed with guarding the opponent's best player and, as Patterson showed in their first meeting, he is the guy for Pitt. Versatile, seasoned, and intelligent as a 6-5 fifth-year senior, he had 19 points on an efficient 8-of-12 shooting in the first meeting between these teams.
Patterson is not afraid to use his body either to bully his way to the basket or create space on the perimeter, but also has the body control around the rim to finish. It will be up to Faust not to lose Patterson defensively, while also keeping him out of the lane. The Pennsylvania native shoots 44 percent from three-point range.
Jake Layman, forward
Layman has been in a funk since the start of the heart of conference play, averaging just 5.5 points per game in conference play. How much of that has to do with defenses keying in on him and how much of it has to do with a shooting slump?
The more Maryland fails to get to the basket, the easier it becomes for defenses to extend out toward the perimeter and limit Laymand and other shooters the Terrapins have. That means that the offensive ecosystem relies on Seth Allen getting to the rim instead of taking jumpers, as well as Dez Wells getting into the paint.
The problem is, Pittsburgh ranks in the Top 75 nationally in opponent three-point shooting percentage at just 31.5 percent.
James Robinson, point guard
It's really incredible that a player who has the ball in his hands for such a significant portion of the game can average less than one turnover per contest. That's what Robinson has done this season. The DeMatha (Md.) product is averaging 4.3 assists and just 0.7 turnovers per game this season, part of the reason that the Panthers' offense runs so efficiently.
And that's where the problem is presented for Maryland. If they fall behind early, trying to pressure Robinson and force turnovers just won't happen.
NCAAB Headlines
CSN Baltimore | Jan 25


text:
Myers Resigns As Era President
Elissa Matulis Myers, president/CEO of the Electronic Retailing Association, resigned from her position, the ERA said Friday. Myers left to tend to her mother, who is in ill health, said Sigi Friedman, special assistant to the president/CEO of the ERA.The ERA is preparing to issue a statement pending the closure of negotiations to finalize Myers' departure. Myers did not immediately respond to calls.
Barbara Tulipane, ERA executive vice president, has assumed the position of interim CEO, Friedman said.


text:
Oktoberfest started in Munich, Germany but the beer festival concept has spread throughout the world, including hundreds of events in North America, and several large Oktoberfests in South America and beyond.
Also visit Oktoberfests in the United States
Here are the dates for the Oktoberfest in Munich, Germany:
The 180th Oktoberfest will be held in Munich, the capital city of Bavaria, in 2013. The first one occurred in 1810, and the event was repeated each year except during wartime.
The official opening ceremonies of the original and world's largest (an estimated six million visitors) Oktoberfest in Munich begin at the Schottenhamel tent. At noon, the Lord Mayor of Munich taps the first keg of Oktoberfest beer. Once the barrel has been tapped, the members of the audience are allowed to quench their thirst. It's quite common for visitors to come around 9am to secure good seats. The festival usually lasts 16 days.
Besides Oktoberfest, Germany has other beer festivals (bierfests), some called "funfairs," like the Cannstatter Volksfest (or Cannstatter Wasen) in Stuttgart, the second largest beer festival in Germany and probably in Europe. The second largest Bavarian festival is the Gäubodenvolksfest in Straubing. The Barthelmarkt in Manching dates back to Roman times. The third largest beer festival in Bavaria is the Bergkirchweih in Erlangen, with one of the largest open-air beer gardens in Europe.
The Oktoberfest Hannover is a fair which takes place every year at the end of September or beginning of October in Hannover, Germany. It usually lasts 16 days and features 160 rides and two large beer tents seating more than a thousand people each, and numerous stands offering refreshments. With more than one million visitors each year it also claims to be the second-largest Oktoberfest in the world.
Oktoberfests occur in many German cities, including the Kölner Oktoberfest, and celebrations in Bonn and Zwickau, Germany.
The Mondial de la Biêre in Strasbourg, France (on the German border) is a beer festival that has a sister version held in Montreal, Canada.
One of the largest Oktoberfests outside of Germany and the United States is the Blumenau Oktoberfest in Santa Catarina, Brazil (Reportedly averages over 750,000 visitors). Several southern cities in Brazil were populated by German people in the 19th and 20th centuries. The Blumenau Oktoberfest has been celebrated annually since 1984. There are 18 days of music, dance and foodcommemorating Brazilian ancestors that came from Germany. In 10 days in 1984, 102,000 people (more than 30% of Blumenau's population) attended and in 1992 more than 1,000,000. The average beer consumption was about one liter per person. The festival has since spread, with festivals in Santa Cruz do Sul in Santa Catarina; Igrejinha in Rio Grande do Sul; and Rolàndiain Paraná.
In Argentina the local edition of the Oktoberfest takes place in Villa General Belgrano in the Province of Córdoba and is called the National Beer Festival.
In Colombia, Oktoberfest is sponsored by Bavaria Brewery. A series of concerts and events are held in different cities, with special emphasis on those with German immigrants like Bucaramanga.
Chile's Fiesta de la Cerveza, or bierfests, are celebrated in Valdivia, Puerto Octay, Puerto Varas, Frutillar and Llanquihue.
For Peru, see the Oktoberfest in Lima and Lima, Peru's Official Oktoberfest Site.
In Mexico an Oktoberfest takes place in the southern part of Mexico in Xochimilco. There is also an event in Merida.
The Hong Kong Oktoberfest was started in 1991. It is celebrated in late October and early November (dry season in Hong Kong) and is hosted by the Marco Polo Hong Kong Hotel in Tsim Sha Tsui, Hong Kong. For the festival, the Marco Polo Hotel sets up a traditional tent with long wooden tables and benches with capacity for approximately 1,500 persons to create an Oktoberfest atmosphere. The German Band Die Notenhobler from Ulm, Germany entertains the approximately 85% Chinese audience.
In Canberra, Australia, the Harmonie German Club Oktoberfest lasts for three days every year in October.
A Vietnamese Oktoberfest celebration has been held in Ho Chi Minh City, Vietnam since 1992. The event is organized by the German Business Association of Vietnam and the Windsor Plaza Hotel with sponsorship from the local business community, including many German companies. The 2009 event ran from October 6-11, attracting more than 10,000 guests who consumed more than 4 tons of sausages, sauerkraut, and meat carvings and over 15,000 liters of German beer.
More Beer Festivals on Wikipedia
Oktoberfests in the United States
Also visit our Austria section
from Cooking with Beer
from Black Forest Cuisine
from Kate's Global Kitchen
More German Recipes
Back to the main Germany page
Germany on Wikipedia
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text:
R.C. Gorman (Native American/Navajo, 1931-2005), Twilight, 1979, lithograph, signed
R.C. Gorman (Native American/Navajo, 1931-2005), Twilight, 1979, lithograph, signed
Item Description:
Signed and dated lower left, numbered lower right 123/135
Appears fine. Please contact email@example.com for specific condition questions.
Height 22.5 in. x Width 30 in.
About The Artist:
R.C. Gorman (1932-2005) was born in Canyon de Chelly, Arizona and died in Santa Fe, New Mexico. He lived in New Mexico, Arizona, California, and Mexico. Gorman defined his own style in his works of abstract female Indian figure paintings and lithographs. R.C. Gorman became one of the Southwest's best known late 20th-century artists.
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text:
WASHINGTON – After beginning the season with two
consecutive wins over nationally ranked opponents at the Hoopsville
National Invitational Classic, CUA moved into the top-25 rankings
on Monday, debuting at No. 14 in the D3Hoops.com poll. The
Cardinals are currently 3-0 on the season following a 74-68 win at
Haverford on Monday evening.
CUA opened the season with an impressive 67-41 win over No. 16
Transylvania on November 16, behind 23 points from Shawn Holmes and
a 53% shooting performance as a team.
One day later, the Cardinals were at it again, this time taking
down No. 19 St. Mary's 65-52 with Chris Kearney posting a
double-double to lead the way (19 points, 12 rebounds).
Kearney finished the two-day stretch averaging 18.5 points on 58%
shooting, to go along with averages of 9 rebounds and 3 blocks,
earning a spot on the D3Hoops.com Team of
the Week for his efforts.
CUA made the largest leap of any team in the nation this week,
jumping from outside the poll all the way up to No. 14. It
marks the first time the Cardinals have been ranked in the top-25
since joining the Landmark Conference; CUA has received votes in
previous polls while in the Landmark.
To view the entire poll, click
here. CUA's first two opponents are still garnering
plenty of attention nationally, with St. Mary's checking in
at No. 25 and Transylvania sitting just outside the poll as the top
team in the others receiving votes category.
No. 14 CUA is back in action on Wednesday, November 28 when the
Cardinals play host to Frostburg State in their home opener.
Tip time is set for 7:30 p.m. in the second game of a CUA
doubleheader with the undefeated women's team hosting
Salisbury at 5:30 earlier that evening.
Strong start sends Cardinals into national rankings at No. 14
Nov 26, 2012


text:
Jacques VilleglťFound objects, ripped posters, radical collages: as part of the New Realism movement of the early 1960s, Jacques Villeglť's work directly influenced his contemporaries, in particular, New York Pop artists Andy Warhol and Roy Lichtenstein. By using everyday objects, the New Realists sought new forms of artistic expression and called into question the role of the artist and the nature of art itself. Villeglť's work with posters that he found in the streets-some ripped by anonymous passers-by or decayed by the passage of time, and some even damaged to the point of illegibility-exhibited his desire to subvert the conventional discourse of advertising and political propaganda. Since the 1960s, Villeglť's work has been exhibited extensively throughout Europe and North America, and forms part of the permanent collection of New York's Museum of Modern Art, as well as many prestigious museums and galleries around the world. Villeglť was a featured artist in the 2006 exhibition "Nouveau Rťalisme: Art and Reality in the 1960s" at Vienna's Museum of Modern Art. Jacques Villeglť is the first English-language book to represent this influential artist. Illustrating his career through a series of essays-a retrospective text, an interview, and over 150 images-the book spans the artist's output from his early work to his most recent projects. |
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Poster Archaeology by Kaira Cabanas | 65 |
An Urban Comedy Jacques Villegle interviewed by Nicolas Bourriaud | 125 |
Peeling Back the Layers of Time by Francois | 161 |
Copyright | |
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Appartement d'hotes Folie Oberkampf
- Free High-Speed Internet
- Pets allowed
- Continental Breakfast
TripAdvisor Reviews Appartement d'hotes Folie Oberkampf Paris
Travel Blogs from Paris
Fun and Snails in Paris
... financial futures will have been ruined! We all went up the Ferris wheel for sunset and got some terrific photos. Sadly you will not get to see these, nor the photos from this day or the next, due to a mishap with our camera SD card which Paul unfortunately lost, but we will retain these images in our minds forever.
P.S. Celebrity spotting: On our way back home to our apartment tonight, we both did a double take as we realised we ...
Last day in Paris!
... more ground and see more sights! It took little time the American couple & I to gain our balance and prepare to leave the practice area... a little longer for an English Mother & daughter team who had never experienced this form of transport!
We headed off for our 3 1/2 hour tour ably lead by Tina from Slovakia, a history student, who shared her vast knowledge of the local area and history as we stopped at many sites along the ...
I love Paris - even in the rain.
... the cost! View right down to the Seine from our window, only 5 minutes walk to the Luxumberg Palace and gardens and within walking distance of everything we want to do.
We love it even if the weather is a bit dicey. Not raining decide to go for a quick walk around the block. End up at the gardens where there is an outdoor exhibition of photos of present day areas where battles of WW 1 were held. A number dedicated to the battle of Sommes and the Australians ...
Allez à Paris
... people. It was far too busy and we didn't manage to find him. Too many people! At 3pm I headed back to the airport. Total chaos! You could not move along the whole street, nor any of the pavement around the Arc de Triomphe! The metro station was busy - and I needed a ticket, luckily the queue wasn't too long. And by the time I made it to the RER train - it was empty! A quick change at Chalet des Halles and the train was then almost direct to Charles du ...
Christmas in Paris!
... 2 sentences of the 2 hour long service being in English, was great to be in there experiencing the service but for us it was more of a game of follow the leader as we stood up/sat down when the people around us did. The organ and bells definitely made it all worthwhile though. My cousins cousin met us out the front with her very adorable dog, we walked the streets back to her apartments stopping off to watch the ice skaters attempt to skate around the professional's ...


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3D printing, starship management, and the magic of science in Detroit. Read More »
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3D Printing Has Unexpected Medical Applications
3D printing is moving into the future at an unprecedented rate. Now, these techniques offer new hope in the field of medicine, and transplants. Read More »


text: NightingaleTereus, King of Thrace, fetched Philomela to visit his wife; but when he reached the "solitudes of Heleas" he dishonoured her, and cut out her tongue that she might not reveal his conduct. Tereus told his wife that Philomela was dead, but Philomela made her story known by weaving it into a peplus, which she sent to her sister, the wife of Tereus, whose name was Procne. Procne, out of revenge, cut up her own son and served it to Tereus; but as soon as the king discovered it he pursued his wife, who fled to Philomela, her sister. To put an end to the sad tale, the gods changed all three into birds; Tereus (2 syl.) became the hawk, his wife the swallow, and Philomela the nightingale. Source: Dictionary of Phrase and Fable, E. Cobham Brewer, 1894