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The Red Jesus Freaks are Green With Envy (updated)
In other words, I am just as lost as this commenter or anyone else, a hypocritical, deluded, rancorous, joyless, and ego-driven preacher with unfashionable homemade footwear. But I somehow manage to obscure this fact by basking in the reflected glow of my half dozen regular commenters who are as bent and twisted as I am.
Could be. Except I would definitely take issue with the "joyless" characterization. I really do enjoy doing this, even before my adoring bobbleheaded clones lavish me with praise and give a boost to my flagging self-esteem.
In all seriousness, as I have had occasion to mention a jumble of tomes, I am not so much concerned with left vs. right as I am with up vs. down, i.e., the vertical. Any secondary political principles I espouse or embrace follow from my first principles, which are timeless, metaphysical, and I believe objectively true. If you want to attack me--which, of course, you are free to do--you cannot begin with my "conservatism" but with the principles from which my conservatism flows, for example, my belief in the absolute spiritual value of liberty over equality.
To the extent that I am a "Republican," it is only insofar as the Republican party is subject to some small influence from the conservative intellectual movement. To the extent that I am part of that latter movement, it is only because I believe it best embodies the ideals of classical liberalism espoused by the American founders. And to the extent that I regard the American founders as political avatars charged with a divine mission, it is only because I believe they designed a system that is most compatible with the spiritual evolution that is my true concern. Everything actually starts with that: my politics follows from my metaphysics.
Along these lines, there is an interesting piece on frontpage.com on the new phenomenon of "Red Letter Christians":
"Frustrated by the conservative tendencies of most religiously active Americans, a group of liberal religious activists have started 'Red Letter Christians' to espouse political themes of the left.
"Referring, of course, to the fact that words of Jesus in Bibles are often printed in red letters, these new 'red-letter' communicators and activists want to steer Christians away from concerns about marriage and abortion and towards antiwar activism and environmental causes."
One of their founders describes the movement as follows: "We are evangelicals who are troubled by what is happening to poor people in America; who are disturbed over environmental policies that are contributing to global warming; who are dismayed over the increasing arrogance of power shown in our country's militarism; who are outraged because government funding is being reduced for schools where students, often from impoverished and dysfunctional homes, are testing poorly; who are upset with the fact that of the 22 industrialized nations America is next to last in the proportion of its national budget (less than two-tenths of 1 percent) that is designated to help the poor of third-world countries; and who are brokenhearted over discrimination against women, people of color, and those who suffer because of their sexual orientation."
These Red Letter Christians clearly work in the opposite direction I do. They begin with their first principles of boilerplate leftism, and then seek to find confirmation for them in the literal words of Jesus, stripped of tradition, orthodoxy, context, symbolism, and spiritual gnosis. In so doing, they reduce the Word of God to the word of Marx, and with that, the vertical to the horizontal, thus defeating the very purpose of religion.
These self-deluded souls insist that they are neither left nor right, but simply following from a literal reading of the words of Jesus (talk about fundamentalism!). For example--who would have guessed--they conclude that God is against tax cuts and against the liberation of Iraq, but in favor of expanding the food stamp program, increasing the minimum wage, keeping all murderers alive, and "loving our enemies," meaning that we must surrender the war on global jihad. Oh, and Jesus also supports renewable energy and the redefinition of marriage.
In short, Jesus was not the word made flesh or the third person of the trinity--show me the red letters where he said any such things--but a 21st century moonbat.
This little exercise proves once again the axiom that the left is animated by feelings, not by thought. Every decent person wishes to help the poor, but these boneheads do not understand that we disagree precisely on the means of accomplishing that. In their minds, they literally believe that a liberal simply wants to help the poor, whereas a conservative wants to harm them. It never occurs to them that a conservative wishes to help the poor every bit as much as they do, but believes that liberal programs, in most cases, demonstrably do more harm than good. I am convinced that nothing in history has helped more people rise above poverty than the discovery of the principles of how wealth is created. Detracting from these principles only ends with less for everyone, especially the poor, as socialism proves time and again.
For example, the billions of dollars that have been given to Africa have overwhelmingly served the purpose of funding corrupt regimes, which only further postpones the day that the nations of Africa will have to address the true source of their poverty, which is in the realm of bad values--i.e., weak property rights, corruption, magical, animistic spiritual beliefs, rampant sexism, and paranoia fueled by unregulated envy. The application of neo-Marxist ideas has only made all of these things worse, not better.
As Dennis Prager noted yesterday, the Biblical injunction to feed the hungry and clothe the poor did not in any way envision the people we now call "poor" in the United States. For one thing, most of these people would be called "middle class" by the standards of Europe, "wealthy" by the standards of Africa, and "royalty" by the standards of the authors of the Bible. I can assure you that they were not thinking of the average "poor" American, who has a house of his own, a car, a cell phone, cable TV, air conditioning, and many expensive tattoos. Nor does he have to cobble his own Nikes, as I do.
Amazingly, some 48% of Americans feel--and the operative word here is feel--that they are worse off than their parents were, which is demonstrably untrue. I mean, it's just flat out wrong. But it does show you how liberals "think," because, as I mentioned a couple of days ago, most of our problems are existential, not a result of this or that circumstance. But because circumstances on earth always more or less suck--to be perfectly accurate, the glass is, and always will be, exactly half full, and therefore half empty--the world becomes a convenient field into which we may project problems that are properly internal, spiritual, psychological, and existential. And this is the perennial appeal of the revolutionary left: your problems are magically shifted outside yourself, even though it necessarily means that their solution never comes.
This externalization is a spiritually disastrous act, for the moment you judge your fortunes by comparing yourself to others, you have opened the door to envy, which is infinite and insatiable. You will always be miserable, because you will always--always--find someone who is better off than you are.
Because we have it so good in this country, the new meme of the left is that the gap is too wide between the wealthy and the rest of us. Personally, I do not compare myself to CEOs, to actors or to rock stars. Rather, I compare myself to my needs, which are quite modest, and to my desires, which are quite limited. Measured in this way, I am aware of existential--not monetary--wealth on a moment by moment basis.
I look at things like my diabetes, which is so much easier to control today than it was for my mother just a generation ago. God bless the profit motive and the greedy pharamceutical companies for that. I look at mundanely miraculous things like a DVD player through which I have instant access to the greatest films of all time, in a way that only the wealthiest person could have dreamt of when I was in film school in the early 80s. I remember a girlfriend I had at the time--it must have been around 1978. Her family was rather well to do, and owned one of the first Betamax video recorders. It was a huge, bulky thing, incredibly expensive, certainly beyond my means. And although my parents could have "afforded" one, I cannot imagine them ever splurging on something so impractical.
But what poor person today--just a quarter century later--would ever settle for a bulky old video recorder? Blue state red letter Jesus would positively freak out at the unfairness of it.
Likewise, a cheap home computer gives one access to a world undreamt of a decade or two ago, at least by me. I am very slow to catch up with technology, so I am acutely aware of how the internet has utterly changed my life. Because of it, I am living a life I couldn't have lived before; I am sitting here right now taking advantage of a technology that allows me to actualize a part of myself and to bask in the narcissistic glow of my fawning readers who gather at my feet with those ugly homemade shoes on them. The joy of creation and communication is so intense that I am astounded by it every day.
That is my idea of progress. The very idea of reverting to a time when one's view of the world was limited by the horizons of the spiritual and intellectual pygmies of the New York Times or L.A. Times is absolutely appalling to me. To return to those days would literally feel like being imprisoned in a psycho-spiritual gulag without light or heat. It would be like being forced to read Pravda or watch CNN, with no alternatives and no way to locate, much less instantly connect with, Our Kind of bent and rancorous seekers.
Life is such an amazing gift when you have a little gratitude instead of a grrr attitude.
It has been given to you to know the mysteries of the kingdom of heaven, but to them it has not been given. For whoever has, to him more will be given, and he will have abundance; but whoever does not have, even what he has will be taken away from him. Therefore I speak to them in parables, because seeing they do not see, and hearing they do not hear, nor do they understand. --Matthew 13:11-13
One more thing. While reflecting back on those old film school days, I remember that at my lowdown-downdest (as Francis Albert would put it), I lived for awhile in a small, unfurnished single apartment near Cal State Northridge, which is the Harvard of the North San Fernando Valley. I had a bed, a good stereo, an outstanding record collection, an ice box full of beer (no refrigerator), and no TV. Plus I drove a 1973 Ford Pinto Wagon. I was happily toiling away as a retail clerk (never full time, mind you, which would have interfered with my sacred Slack), which I did from 1976-1988, the same year that I completed my Ph.D.
In any event, at no point did it ever cross my mind that I was "poor" or that Red Jesus would have taken pity on me for the rude circumstances of my otherwise happy and inebriated existence. Referring back to that girlfriend with the wealthy stepfather, it never occurred to me to envy him. For one thing, I knew that he might have all the money, but that I was having all the fun. Still am.


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NEW YORK McDonald's Corp. (MCD) reported a second-quarter profit that fell shy of expectations and warned of a tough year ahead.
The world's biggest hamburger chain also said July sales are expected to be flat.
The company, based in Oak Brook, Illinois, says global sales edged up 1 percent at restaurants open at least a year in the quarter. The figure rose by the same amount in the U.S., where the company has been introducing new menu items such as chicken wraps and egg-white breakfast sandwiches
For the quarter, the company earned $1.4 billion, or $1.38 per share. That's up from $1.35 billion, or $1.32 per share, a year ago.
Earnings were short of the $1.40 analysts expected.
Revenue rose to $7.08 billion, in line with expectations.

subset: commoncrawl


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Testimonies: Esophageal Cancer |
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Page 1 Testimonies Per Page: [5] (10) [25] [50] [ALL] |


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Dell PowerVault DDS Cleaning cartridges have a lifespan of up to 50 cleans.Regularly cleaning DDS/DAT drives help in long-term reliability and should be conducted in scheduled cycles and when requested by the drive. The recommended cleaning interval for the drive is 50 tape motion hours, which is indicated by the solid LED.
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Without a doubt, Niagara Falls is one of the most impressive waterfalls in the world. The sheer amount of water surging around you is simply sublime. In fact, when Austrian composer Gustave Mahler first encountered the falls, he is said to have exclaimed, "At last, fortissimo!"
Over 28 million tourists visit the falls every year. If you'd like to be one of them, first make sure you have the travel documents you need for your desired itinerary. Do you need a passport to go to Niagara Falls? The Niagara River straddles the Canadian border, so the answer depends on which side of the attraction you'll be touring. The American Falls and Bridal Veils Falls are both on the US side of the border. However, their bigger brother Horseshoe Falls is on the Canadian side. There are plenty of waterfall-related activities and vantage points on both sides of the border, but the view from the Canadian side is generally considered to be the most impressive.
Obviously, if you're going to stay in New York, you won't need a passport. However, if you want the full Niagara Falls experience, you'll need to cross the border into Ontario. In that case, you may need a passport. Here's what Niagara Falls Live has to say about the matter:
U.S. CITIZENS RETURNING TO THE U.S. AFTER VISITING NIAGARA FALLS CANADA ARE REQUIRED TO PROVIDE A PASSPORT, PASSPORT CARD OR ENHANCED DRIVERS LICENSE AT THE IMMIGRATION CHECKPOINT. If you are a U.S. citizen living in the U.S. and cross the border to Canada and attempt to re-enter the U.S. you will need one of the above listed forms of identification.
Until June of 2009, this wasn't the case, and you can see from the emphatic combination of all-caps and red font that many travelers still show up unprepared. Don't be one of them- get a passport, a passport card or another acceptable form of ID. Trusted traveler cards like NEXUS, FAST and SENTRI cards can also be used to cross, though they are much less common and more of a hassle to acquire. Please note, if you are flying from the US to Canada, you'll need a passport book, not a passport card and not one of the alternate IDs. See Do You Need a Passport to Go to Canada? for more information.
Niagara Falls Activities
- Maid of the Mist tours: The Maid of the Mist boats take travelers on either side of the border past the American and Bridal Veil Falls, and then right into the mist coming off the Horseshoe Falls.
- The Cave of the Winds takes you right up to the base of Bridal Veil Falls, where winds can reach over 60 mph.
- On the American side, the Niagara Scenic Trolley takes you around the American Falls and Goat Island.
- Queen Victoria Park, in Ontario, provides a lush, gorgeous setting in which to view the falls.
- Skylon Tower, also on the Canadian side, lets you take in the view from 520 feet in the air.
- The Whirlpool Aero Car is an old-fashioned cable car, built in 1916, that takes you over the Niagara Whirlpool.
Fun Facts About Niagara Falls
When you go, here's some interesting trivia to keep in mind:
- During high season, about 100,000 cubic feet of water tumble almost 200 feet down the falls. If the falls weren't used to generate hydroelectric power, the volume would be about twice that. The falls are at their peak during the spring and summer. Unfortunately, so are the crowds.
- The first person to go over Niagara Falls in a barrel was a 63-year-old teacher named Annie Edson Taylor. She survived, but immediately proclaimed "No one ought ever do that again." Daredevils and publicity hounds alike have spent the past century ignoring her advice.
- The first mammal to go over the falls in a barrel was a cat named Iagara. Taylor sent her down first, only attempting the stunt herself after the cat emerged from the falls unscathed. PETA would definitely not have approved.
- Stunts are prohibited at and around the falls without a permit, but both the US and Canadian governments have agreed to make an exception for the Flying Wallenda family, who will be walking over the falls on tightropes this summer.
If you're planning a trip to Niagara Falls and you need a passport, check the Department of State's current processing times before you apply. In general, it takes about six weeks to get your passport back in the mail if you apply with regular processing. If you pay the extra $60 for the State Department's expedited option, you'll still find yourself waiting about three weeks.
For faster service, you can either make an appointment at one of the country's 24 Regional Passport Agencies or you can use a private expediter like RushMyPassport. We personally deliver your application to the Department of State for processing in as little as 24 hours, so you can see Niagara Falls from both sides. If you need help getting your passport application processed quickly, contact us today!


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For Meg Matthews, the shoe is now firmly fitted on the other foot.
— Here's a team-by-team look at the area's softball teams as the season kicks into high gear. Nazareth, St. Hubert and Archbishop Ryan all have title aspirations.
"We didn't start off great, but I think a lot of that was losing our coach," Matthews said after burning Haddon Township for 25 of her team's 50 points.


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bathroom murder scene
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Angel Foice gave props (12 Nov 2009):
oh yeah. rocks!
Also by Lindsey Jackson


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Children's Theater Runs Until Aug. 20
The critically acclaimed Occidental Children's Theater will celebrate its 10th year with "Little Red Frankenhood," an original story, plus three adventurous adaptations of traditional folktales for a seven-week outdoor run in the Remsen Bird Hillside Theater on the Occidental campus.
In about an hour, a cast of six recent Occidental alumni will perform four energetic and funny stories without props, sets or special costumes, relying only on their acting and acrobatic skills. "The cast carries it off with the unflagging charm that has made this reliable company one of the Southland's – and the summer's – most entertaining children's theater offerings," wrote the Los Angeles Times.
The scripts and the action for the tales are company-created and the result of weeks of improvisation and revision. The three traditional stories are the troupe's versions of existing folk tales from around the world, while the title story was developed by actors and Jamie Angell, the theater's founding artistic director.
"We work in the round, so the audience is right on top of the action," Angell said. "The unconventional material and the absence of props or costumes force both the actors and the audience to rely on their imaginations. It's remarkably different from most anything else you see in children's theater today."
Beginning July 7, "Little Red Frankenhood" will be performed in the Hillside Theater at 10 a.m. every Thursday, Friday and Saturday through Aug. 20. Tickets are $9 for adults and $6 for children ages 2 to 12. Group rates are available.
For ticket information, call the Occidental Box Office at (323) 259-2922.
Occidental College is located at 1600 Campus Road in the Eagle Rock section of Los Angeles. For a campus map and directions to the college, click here.


text: 1862The U.S. Department of Agriculture was created by an act of Congress on this day. 1911The Standard Oil Company, headed by John D. Rockefeller, was ordered dissolved by the Supreme Court, under the Sherman Antitrust Act. 1918The first air mail route in the U.S. was established between New York and Washington, DC, with a stop at Philadelphia. 1930On a Boeing Air Transport flight between Oakland and Chicago, Ellen Church became the first airline stewardess. 1940Nylon stockings went on sale for the first time in the United States. 1972Alabama Governor George Wallace was shot and crippled as he campaigned for the presidency. 1988The Soviet Union began to withdraw its estimated 115,000 troops from Afghanistan. |


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Sexalicious wide net fishnet stockings plus matching fishnet garter belt with four adjustable suspenders. Comfortable, durable spandex-fabric. Beyond hot!
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Music Legs Spandex Industrial Fishnet Garter Stockings Set 11 4.5 out of 5 stars
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Music Legs Spandex Industrial Fishnet Garter Stockings Set
Reviewed: 20 February 2015 by tornwings, a Bisexual Going Steady Female
I love this set. The stocking and garter look so sexy on. I have got to say, not only did I feel sexy but my OH loved them as well.
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I loved the feel of them as well, and found myself running my hands up my legs at every opportunity. I also left them on during sex, and it definitely made the night hotter. Had a fantastic experience.
- Pros
- Felt and looked sexy.
- Cons
- Nothing.
- Bottom line
- Excellent items, definitely worth it.
- Was this review helpful to you? Yes
Industrial sex appeal
Reviewed: 10 October 2014 by wood nymph
The stockings and suspenders are made of very wide woven fishnet. The garter/suspender slides on and you can just pull it to where it fits best.
The stockings are easy to put on, and when on look and feel very sexy. The clasps to attach stockings are a bit fiddly and I had to have several goes before they were secure. There is no extra stitching round the toe area.
I wore them with crotchless knickers, had the desired effect and some.
- Pros
- Easily put on.
- Cons
- Fiddly clasps.
- Bottom line
- Does what it says on the tin, very sexy!
- 1 person found this review helpful. Was this review helpful to you? Yes
Loved it
Reviewed: 25 June 2014 by Curly_Wurly, a Bisexual Going Steady Female
These were a great buy!
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These were a great fit. I only had one issue... the straps at the front were not tight enough, which made it a little loose and did not stay in place as perfectly as it should. I then thought that I could replace the straps, only to realize that they cannot be removed. This is the only downfall.
I love these and think the fishnet garter is sexy and something different.
- Pros
- Everything.
- Cons
- Being picky, the straps being too loose and non detachable.
- Bottom line
- I love these and would encourage anyone to buy these. Great value for money.
- 1 person found this review helpful. Was this review helpful to you? Yes
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text:
So What's that ONE little thing ???
So what is that one little thing? That one part, one repair, one adjustment, one little task that wears out your patience and makes you want to scream....
Oh, C'MON ALREADY!!! Tonight I was going to replace the skids on my 450. The spare skids I have are Align and I'm trying to get that Little black ball cap into the end of the tube. The backs went in fine but the fronts..... Oh C'MON !! 22 attempts later. Shave the edges, spit, soap, pliers, tweezers and ........ / Walks Away I'm sure everyone has one of those little things, that should be so much easier than it is and makes you wanna scream....or walk away. Paul |
The bottom Jesus bolt always gives me hell, I don't know why. The servo tabs on the old helis like the 450SA used to bother me until I learned to just glue them on
The caps on the legs are a pain, but the one-piece gear solves that issue. The Pro is a little easier to work on too because of only the two frames instead of four. |
you mean like when you take off a servo horn to set the POT you get every thing back together and then for some ungodly reason the same horn wont go back on and your like
WHAT THE OMG what sorcery is this HOW..... is this even possible true story it took me like 2 hours to get it back on lol thats include taking random breaks to pull my hair out and kick my little chiwawa across the room out of anger lol not really i would never hurt an animal but i wanted too lol |
Last edited by countrybo89; Mar 01, 2013 at 10:55 PM.
The plastic servo-retaining thingies on my T-Rex 500 caused me a lot of grief the other day -- especially the ones for the "elevator" servo. Stuck them in place with 2-sided sticky tape, but they pushed off when I inserted the screws; stuck them with CA, and they still came off the first couple of times. Eventually CA and kicker, and wait while they cured, did the job.
For the front two servos I eventually removed the battery mounting plate, and was able to get my fingers in to hold them in place. But to do that I had to Dremel a slot in one of the soft-as-chocolate Align screws I suppose I could have removed the anti-rotation bracket to do the same at the rear ... |
How many have dropped a screw or nut or washer. On the bench or worse....on the floor?
I've spent 20-30 minutes with a 275 lumen flash light looking for a screw that's gone! I'm serious.....it must be gone!! Because its not HERE! Did it accelerate to the speed of vaporization on the way down? Maybe it caught a thermal and drifted to my neighbors house? Maybe it's being coy and playing hide and seek? I believe if I had a Toshiba VGX1000 forensic evidence vacuum that it STILL would not turn up...because its NOT HERE!. And that's not counting the times I DID FIND IT stuck to the motor, or one of my magnetic tools that I hung back on the magnabar. Or once, inside my sneaker? REALLY!?!? Paul |
I learn from my mistakes usually. Like installing the boom and adjusting the belt tension before realizing I forgot to mount the servo and pushrod guides on a 450 or 500. I've only done that 4 or 5 times.
I'm pretty mechanically inclined, and only could complain about disconnecting links in tight quarters with my Align link pliers. I don't hate anything, except for the dumb thumb where I have to spend another 3 hours on the bench when I am too unfocused to fly that last battery of the day. |
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Discussion | It's the little things ... | logan5 | Life, The Universe, and Politics | 8 | Jan 29, 2013 07:02 PM |
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The 5th annual London Indian Film Festival screens a barrage of award winning films
The multitalented Farhan Akhtar will deliver a screen talk at the prestigious British Film Institute in London as part of the fifth annual London Indian Film Festival (July 10-17). He'll take a couple of days break from shooting sister Zoya Akhtar's Dil Dhadakne Do to attend the festival. Farhan says, "At its heart, Cinema is about sharing ones culture with the world. Be it on screen or in representation of ones work. I look forward to sharing my experiences, memories and motivations."
Samruddhi Porey's moving and uplifting Hemalkasa, a biopic about Magsasay award winning couple doctors Prakash Baba Amte and Mandakini Amte, starring Nana Patekar and Sonali Kulkarni, has bagged the festival's coveted closing night slot and will celebrate its World Premiere there. As previously announced in these pages, the festival, Europe's largest celebration of South Asian cinema will open with child trafficking drama Sold, produced by actress Emma Thompson and starring Gillian Anderson, Parambrata Chatterjee and Seema Biswas.
Another World Premiere is Munsur Ali's Bangladesh liberation struggle film Shongram, starring Anupam Kher and Italian diva Asia Argento. The festival will also host the European premiere of baseball film Million Dollar Arm, starring Suraj Sharma , Madhur Mittal and Jon Hamm , with music by AR Rahman.
Another highlight is Amit V Masurkar's Bollywood expose Sulemani Keeda, featuring a host of celebrities in cameos. India's greatest cinematographer Santosh Sivan will also deliver a talk at the British Film Institute.
Cary Rajinder Sawhney, Festival Director comments, "We are delighted that the festival is now firmly established on the London and international scene after five amazing years. If you want to find out more about South Asian cinema, come to London and soak yourself in a week of magnificent, world class cinema".


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Homiletics Workshop: Preaching to End Hunger
The Rev. Dr. James Forbes Jr., is traveling the country, conveying God's message that we can end hunger. He is preaching in churches and leading homiletics workshops for ministers, pastors, and others who also preach to end hunger. Rev. Forbes is senior minister emeritus of the Riverside Church in New York City and president of the Healing of the Nations Foundation. Before being called to Riverside's pulpit, Forbes spent 15 years as a professor of preaching at Union Theological Seminary in New York City. Because of his extensive career and his charismatic style. Forbes is often introduced as the preacher's preacher. In 1996, Newsweek recognized him as one of the 12 "most effective preachers." Check Rev. Forbes' schedule to see if he is visiting a church near you.
Start Date:
End Date:
1400 Shepherd St.
Washington, DC 20017


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Some Nights No Cars at AllThis is the first book by a poet whose imagination is intimately related to the physical world around him, which he describes as "a wholly new and startling landscape that is the acolyte deserts of Arizona. Living here on the moon, as it were, and for half of the year in nearly unbearable temperatures, something altogether interior visited me. The experience of this landscape is confused by its actual history—on the one hand, geological, on the other hand, recent and territorial, and in the great middle ranges, the profound consciousness of Anasazi and Hohokam. They say, here, just to walk on the ground is to dream." Josh Rathkamp's language is plainspoken but emotionally charged. He writes about love (both its pleasures and its difficulties) and of the strangeness of consciousness itself with a confidence that can only come from experience that's been scrutinized and distilled. At first glance quiet and modest, these poems gather considerable force as the book takes us deeper and deeper into questions essential to us all: Can love survive our limitations? What is art, and why do we need it? How can we speak of human consciousness? Josh Rathkamp was born in Saginaw, Michigan. He received a BA from Western Michigan University and an MFA from Arizona State University. His work has appeared in numerous literary journals, including Indiana Review, Fugue, Meridian, Passages North, Puerto del Sol, Rhino, and Drunken Boat. He currently teaches at Arizona State University and Phoenix College. |
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Hotel El Patio
TripAdvisor Reviews Hotel El Patio Ogijares
Travel Blogs from Ogijares
On the road again!
Up early for another wonderful breakfast before collecting the car and heading off to Granada. We took the A45 but turned off to Zuheros. Zuheros is a town that sits on the side of a rocky mountain, the road is rather narrow and winding to get there. We parked outside of town and walked in. We had a drink at what seemed to be the only cafe, I got the feeling that visitors aren't common there and that we were a bit ...
Only Rats & Horses
... pubs, Irish bars and clubbing to all hours, but beyond the coast line it has so much more to offer. Guilty of partaking in one or two of the above (well all, apart from the clubbing) we've grown to appreciate its surrounding beauty in the not too far away hills. The towering folds of the Andaluc�an Mountains visible from everywhere you go, wrap around you like a comforting blanket and rival anywhere we've seen for beauty, especially this time ...
Exploring Granada
... in my hand they had noticed it was the same as theres. We slowly gathered a few more people - of course the English speakers :-). Our tour group seems to the quite disorganised compared to the other tour groups. It took around 20 minutes for the tour leaders to separate everyone onto their languages and then check off their tickets. There was another Australian couple from Sydney who had just completed the Camino on foot for their second time. They were not too chatty so I didn't get ...
Hello maddah, hello faddah!
... is magnificent though, as are the stained glass windows. We went back to the apartment for a rest before heading out again later for more drinks and free tapas! It was so hard to pick where to go given the hundreds to choose from, and none compared to El Retiro! This night be managed to stay out partying later than the oldies at least (although not by much)!
Next day was Alhambra day. Upon Jose's advice we walked up from Plaza Nueva through the Puerta de las ...
Day 185-186: a new phone and a sick Paul
... yay! The man at reception was so nice and friendly. He gave us a map and showed us what to see. He even looked up bus timetables for us to visit the Sierra Nevada mountains. We like this place already! He gave us the keys to our room and up we went. It was a Tiny little thing, but had a heater and a bathroom which was nearby, so it was just fine. We then went downstairs and cooked up some ravioli with alioli and tomato salsa for lunch in the not ...
Other places to stay in Ogijares
Hotel Triunfo Granada Sur
Principal, s/n. Poligono Tecnologico, Ogijares | 4 star hotelfrom $70


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I am pleased and excited to announce a new member benefit offered in partnership with Polytechnic Institute of New York University (NYU-Poly). AITP members will receive a 10% tuition rebate upon successful completion of any online course at NYU-Poly. This can lead to significant savings for an AITP member who is pursuing a Master's degree.
NYU-Poly (http://www.poly.edu/) is a comprehensive school of engineering, applied sciences, technology and research. It is a fully-accredited institution of higher education that has been at the forefront of teaching the latest technical innovations since its beginning over 150 years ago. U.S. News & World Report, widely known for rating educational institutions, ranks NYU-Poly among the best engineering graduate schools in several measures of the quality of distance learning.
NYU-ePoly, the online learning initiative of NYU-Poly, provides 15 online Master's degrees and 56 online courses for certificate and Master's programs. The graduate degrees offered by NYU-ePoly (http://www.poly.edu/nyuepoly) include Bioinformatics, Cybersecurity, Electrical Engineering, Manufacturing Engineering, Organizational Behavior, and Wireless innovation. The degree programs and courses incorporate the latest in technology to ensure that you will lead in your field of study or practice.
Watch for more information on NYU-Poly under the eLearning tab on http://www.aitp.org/. But why wait! You can start taking courses and webinars today. If you are interested in applying for the AITP Society rebate, visit http://www.poly.edu/societyrebate. You can learn more about the NYU-Poly Society Member Rebates at http://www.poly.edu/EnterpriseLearning/society-cosponsors/rebate.
On a final note, I want to thank Association Secretary Barbara Viola for bringing this opportunity to us!
3/1/2017IT Insights Newsletter!
2/16/2017AITP Welcomes New Members - January 2017
2/16/2017FITE Scholarships Now Being Accepted
2/9/2017FITE Scholarships Now Being Accepted
2/2/2017SCOPA Winners Announced
4/13/2017Monthly Meeting for AITP-Charleston
4/19/2017AITP Dallas - April 2017 Meeting with Jim Gardner
4/25/2017AITP-LI 2017 Annual Scholarship Awards and Education Showcase
5/24/2017Dallas May 2017 Meeting with Barbie Bigelow
6/21/2017Dallas June 2017 Meeting with Phil Farr
Stay connected with AITP!
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So I'm having dinner with my wife and my parents and we start talking about tennis. My step-dad says to go through his old frames and if we see anything we like, to take it. So I did. I'm gonna do some research on it, have heard of them but know nothing, other than that they were made in the US, it's 340gr strung and has a 16x18 pattern.
The grommets are in decent shape. The leather seems playable. No cracks. Seems like a solid frame. I don't know how many sq.in the face is but the bag and racquet seem to be of very high quality materials. I want to re-string, re-grip and if I can somehow replace some grommets or the entire bumper (don't know how hard that would be to obtain) and take it out for a spin. But then I thought, maybe this puppy is worth something? Is it? At any rate, it might be about time to start collecting some of these classic frames, in particular Head frames, I've long enjoyed variations of the PrestigeMid. I'm 33 y.o., so the majority are before my time (many before I was born). If anybody has any facts/impressions about this frame, they would be appreciated. I'll keep on researching.
A lot of aluminum frames (Donnays, ProKennex and wilson's) that I can't remember the names of, some woodies in very bad condition and a few more graphite sticks. ProKennex Boron (something like that) a wilson sting and another head frame, a grey one, similar to the TXE but all the markings were rubbed off. He's given me some frames over the past years (especially when I was younger), the only one I have left is an adidas GTX pro (the red one) and an old Rawlings (1962) woodie my mother gave to me.
I laid it on top of an MgPresMid and it's significantly smaller (the TXE edge), my guess is around 80sq.in. The leather grip has Babolat finishing tape on it. Maybe he switched the grip out? Doesn't seem like that kind of guy. Did Babolat provide the leather grips for Head racquets once upon a time? Still don't know what it's made out of. It doesn't say 'Twaron' or fiberglass, just graphite. Checked out some auctions and the prices vary, based on condition. I'd like to keep it. Do a loose grommet fix on the 2 or 3 grommets that are cracked and swap the leather out.
That's not Babolat finishing tape on the racquet. That's Babolat head protection tape that was put on to replace the finishing tape. A common practice back in the day when you did not have any finishing tape. That looks like the original grip that came with the racquet. There is no Twaron in the TXE. Its graphite and fiberglass. Head size is 81 sq.in.
Thanks for that VS, was hoping you'd chime-in. I'm guessing this series came out after the Graphite Edge 2 and was right before the Comp Master/Graphite Master? So what, circa 1985? I'm wondering if it's worth fixing up. It looks to be in very good shape. The strings haven't eaten through the bridge yet (as this is quite common from what I've read) and the grip, although pushed back in two spots, is still playable. Replace a grommet or two and it's good to go. Should I play with it? I mean, is this thing worth anything? For a 30 year old racquet, it's holding up nice. Don't understand why some people don't cut the strings out of some of these classic frames when stored?
The Graphite Edge TXE came out after the Graphite Edge. The Graphite Edge TXE came out in 1984. Yours with the USA Flag on it is a is a later production from 1985. It was before the Graphite Pro/Comp Pro line. The Graphite Edge 2 came out 1988.
I remember seeing that frame. It's nice. I used to use a graphite Edge back then, an excellent and responsive frame. You should play with this.
very hard. i don't know anywhere that still has grommet strips for the TXE. you might need to cut up a head grommet set and piece it together. will be a challenge for sure. best to grind out the 2 or 3 grommets that are split or cracked with a grommet grinder and then drop in a Fittex individual grommet.
i believe the TXE and TXD came w/ Fairway leather grips so you should be able to clean it up and restore it w/ some castor oil.
Thanks for the tips MadDog. Castor oil? Huh... got a bottle lying around somewhere. Would olive oil work as well? That's the plan. Re-store it (the little work it needs) and enjoy it. Don't see much of a resale market for them anyway, so might as well have some fun with it.
here are the care instructions from Fairway...i wouldn't recommend using olive oil. The Fairway grip is the best in the world. It is produced from the finest calf skin obtainable and will retain its tackiness indefinitely, provided you look after it. You will find after considerable use your grip appears to be losing its "tack." This is only because it needs cleaning and the best way of doing this is to saturate a cloth in methylated spirits (denatured wood alcohol) and rub it over the grip (this will remove all the dirt which has collected on the surface). Allow about half an hour for the spirit to evaporate from the leather, then apply a small quantity of castor oil. Allow eight hours for the oil to penetrate into the leather and your grip will be ready for use and will again feel as good as new. Do not apply too much castor oil as this will result in making the grip greasy. We strongly advise you to ask your Professional to carry out the treatment recommended by us in this folder. E. B. BALMFORTH LTD 2/4 MEANWOOD ROAD LEEDS LS7 2AD
^Thanks. Amazing how much quality and craftsmanship was put into these 'classic' frames, not to mention better materials. A shame I missed this era of racquets. Everything nowadays seems cheap, rushed and over-marketed.
There are a lot of differences between the two. Head size, string pattern, composition, feel, flex. To make it really simple The TXP=Prestige Pro.
The TXP has full caps, 18x20 pattern and is 89.5sq.in.?!.... so this is the first or pre-cursor to the PrestigeMid? Seems like it was produced much later than the graphite edge TXE and has twaron. Very nice racquet. Too bad I can't find a used one under $150.
The TXP is the same exact racquet as the Prestige Pro. The only difference is the paint and marketing. When the Prestige Pro first came out in late summer of 1986 HEAD decided to market the frame as the TXP in the USA. So the USA got the Prestige Pro painted white with TXP written on it.
I never question your knowledge or where it comes from but I'm glad you're a poster on TT. Thank you once again VS.
You're welcome. HEAD did not start selling the Prestige Pro as the Prestige Pro in USA until 1988, if you know what I mean. Let us all know how you like the TXE.
Gotchya. Will do, haven't had a chance to hit with it, yet. Looking at new fairway grips. Must say, there is quite a price discrepancy between them and the others.
Why Fairway, if I may ask? They are expensive because they are chemically treated not to slip. However, this is relevant only if you do not use overgrips. Balmforth makes some untreated grips that are just as nice and quite less expensive. If you use an overgrip, I would go with those.
^I'm learning something every post in this thread. Good Lookin'. I wanted to stay true to the stock grip on the TXE, it seems nice and soft, unlike most leather grips. Did not realize there were more than one type of Balmforth grips (fairway). Being as I do play with an over-grip, it's not necessary to go over-board, price-wise. Thanks.
Went out for a hit last night and brought the TXE with me. Fantastic feeling frame, felt like a graphite woodie (minus the flex), as in the weight is nicely centered (yoke area) and well balanced. Comes around beautifully on 1hdr's, slice and serve. The graphite/fiberglass composition is reminiscent of some Volkl frames I've tried but the TXE felt noticeably more firm. Really a great hit. Makes me want to hunt down a TXP, as it's closer spec-wise to the PresMids I've enjoyed for so long.
I HAD this frame, and it was not good! I had a donnay plus 35, which i realize now is probably a 93 to 95 square inch frame, and it is miles better than this frame. With what i know about customization with lead now, I probably could make it a good frame. But, it was a very small head size and not very stable. I think the only thing i could do decent with it was serve. I realize i have been using some form of the red head prestige since then and currently use the head microgel 98(which is actually more of 95 sq. inches). Also, the small pattern was not good for spin production either(again, better strings of today could also correct a lot of this. I ended up selling it to my buddy but then thought i regretted it, got another one used, and then realized all the reasons i didn't like it! haha But, good luck with it, again, maybe with some lead on 9 and 3, or all around the sides of the head(like I do on my microgel, and the stability issues might correct themselves!
Well, the TXP is a Prestige Mid... the first version, actually. I playtested the TXP extensively when it was introduced in the US in 1986. By comparison with the TXE, it felt harsh and "tinny," and had an annoying "tweet" with each swing (from air whistling through the CAP bumper's slot). I could hit a harder and heavier ball with the TXE - its string pattern was a bit more open. I've hit with about everything Head has produced from 1983 to today, and the TXE remains my second favorite Head frame, behind the 1988 Elite Pro. FYI: while TXE grommets and bumpers have been NLA for quite a while, the bumper and grommet from a Graphite Edge 2 or Special Edition Edge are the same exact article, and can be carefully "harvested" from a donor frame to keep a TXE alive.
I didn't realize Fairway was back alive in the grip business; I should look this up! Good news if they are. Fiberglass is a wonderful ingredient to add to a graphite racquet; really is good stuff.
I remember how popular the Graphite Edge and TXE was at my club at the time. The three most popular midsize racquets at my club in '84 was the Wilson Pro Staff, HEAD Graphite Edge, and TXE
The Sting was made to be more "affordable", thus the prominence. It was the "poor man's" POG. all of those rackets were popular at the time, as well as PK and Wimbledon.
Don't forget the oddball Kneissl frame. What a game changer as it were that winter when Prince came out with their Midsize frames with the 90 Series. There was a lot of Graphite 90's after that.
I was the odd man out with the Kneissl frames for a long time! Oddly, there were a few guys with F200's in my club. And quite a few Prince Pros, and Graphite Edges, the odd TXE and TXD, lots of Prince Graphite 110's and Max 200g's. And original Pro Staff 85's, of course, thought there were a few Javelins around before the PS85.
Nobody used the Javelins at my Club back then. It was the Ultra, Ultra 2, and some Stings before the Pro Staff. I think it also helped that just about every coach at my Club used the Graphite Edge.


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Looking for the lowest price on a new 328i? The Bimmerfest.com Internet Special!
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These prices seem to be MSRP and not invoice. Or, was it in an other area?
When you enter the configurator and select the vehicle you want to configure (i.e. 2013 328i sedan) the left hand section will display the first option screen with your choice of exterior colors. The right hand section will display the build of your car with all options selected thus far and will also display two columns of numbers, the MSRP in the left column and the Invoice in the right column. The pull down menu at the top of this section allows you to select the delivery location. As you select the different delivery locations the MSRP and Invoice pricing will adjust accordingly. So, you are able to see the MSRP and Invoice price of each individual option selected and as a car total for European Delivery, USA Delivery, or Diplomatic USA delivery.
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Orders placed today should arrive on or before Saturday, April 08, 2017
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Huntington Beach star makes first MLB start
September 15th, 2010, 1:40 pm by DAN WOIKE, THE ORANGE COUNTY REGISTERThe Angels' Hank Conger will make his first start in the majors today against Cleveland. Conger is catching and batting eighth.
Conger struck out in his major-league debut. Conger was the MVP of the All-Star Futures Game earlier this season.
More on the Angels: [rssfeedme cat="fromthedugout" feedpath="/category/angels/feed/" max="6"]
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Penname: | Emandem | Member Since: | 2010.10.10 |
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: Shuntbumps by Emandem
Novella He's almost a tyrant. She's ridiculously submissive. Oliver Wood and Louise Deverill are the perfect couple. Until he knocks her off her metaphorical broomstick and leaves her with nothing but a determination to return the blow - even if it means socializing with very questionable people, or having to make decisions for once in her life. Genres: Humor, Romance, Young Adult Era: Hogwarts Characters: Fred, George, Harry, McGonagall, OC, Oliver, OtherCanon , Percy, Snape Pairings: Other Pairing, OC/OC Advisory: Strong Language, Mild Violence, Scenes of a Mild Sexual Nature Published: 2011.05.29 Latest Chapter: 2012.06.02 Updated: 2012.06.02 Status: WIP (2225 words) |


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The modern media consumer has developed quite a talent for zoning-out marketing messages intended to engage them across pretty much all platforms, be it television, radio or digital. Lives are busier and the choices are seemingly limitless.
The trick for business now is to stop shouting at their consumers with intrusive and interruptive advertising and focus instead on building relationships with their consumers. This 'conversational' non-interruptive approach has seen the rise of what's become known as content marketing.
Earn the attention of consumers
The most effective way to get a customer's attention is to earn it by engaging in conversation via content marketing. This, in simple terms, is the creation and distribution of relevant content or information to a defined target audience, over a long term, to build relationships and in turn profits.
Digital distribution channels such as social networks, blogs and websites have made it possible for brands to become content creators themselves rather than needing to sponsor traditional media channels. Business no longer has to rely on media publishers as the gateway or the gatekeeper to an audience.
A targeted approach
But while you can now be your own publisher, the question of quality becomes critical. Consumers want content that adds real value to their lives, which means not targeting them with thinly veiled sales speak. Think about the media you consume. Why is it that you visit a favourite website every day, or buy a particular magazine or your choice of newspaper? Useful, useable, desirable content is non-negotiable when it comes to engaging with your online community. The content you place on your site is what defines your brand to the world of customers and potential customers.
By providing visitors to your site with engaging and relevant news and information rather than simple "buy now!" messages, you are ensuring a better, more enjoyable and memorable user experience. This in turn means visitors to your digital real estate will linger longer and you'll generate more referrals to your site.
It's not a one-off though. A smattering of interesting pieces uploaded once and forgotten about will yield nothing. You must add new, interesting material to keep your existing audience tuned in and it's also the best way to develop new audiences. The constant updating of content on your business site is of course also important for search engine optimisation. The internet is a crowded place – without a steady stream of updated content you risk your site being invisible to search engines.
Content marketing should form a key component of any business' ongoing sales or customer retention strategy, and arguably also affords the greatest opportunity. Think of it as a long-term relationship – the more you put into it over time the more it grows and the more rewarding it becomes.


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Rafael Benitez has warned John Terry a place in his first XI is not guaranteed after the Chelsea captain's fitness travails.
The 32-year-old has started twice for the Blues under Benitez, who was appointed interim boss in November, and was an unused substitute in last night's 1-0 Europa League last-32 first-leg win at Sparta Prague despite being available following a knee injury.
Branislav Ivanovic and Gary Cahill played in central defence as last season's Champions League winners recorded back-to-back wins for the first time since December and kept a clean sheet for a second time in eight games.
"He (Terry) had a setback," Benitez said. "After he was fine again. He had no reaction in the next training session.
"It's a vicious circle: if he cannot play, he cannot improve his match fitness. We have to manage.
"In the meantime if Cahill and Ivanovic are doing well at least we can keep winning games."
Terry may yet return for Sunday's FA Cup fourth-round replay with Brentford.
Fernando Torres' most recent goal came in the drawn original tie with the npower League One club.
The £50million striker now has one goal in 13 games after missing a number of chances against Sparta, his evening summed up by a sliced second-half shot which went out for a throw-in in another impotent display at the Generali Arena.
Benitez, who managed Torres at Liverpool, refused to criticise his compatriot, even though the World Cup winner missed a straightforward attempt after 35 minutes, did not make an effort to meet two early crosses from Eden Hazard and looked disinterested at times.
"We have to create more opportunities and the strikers will score more goals," Benitez said.
"His work rate was really good and thanks to him the rest of the team, especially the second line of offensive players, they could create.
"Everybody expects from a striker just to score goals, but he's doing also a great job for the team."
Nevertheless Benitez called for Chelsea to be more clinical after Oscar came off the bench to score the winner eight minutes from time to claim the lead ahead of next week's second leg at Stamford Bridge.
"Eighteen attempts away is not bad, but we have to be more clinical in attack," Benitez said.
"We have scored the away goal and we have to finish the job at home."
Like Terry, Ashley Cole was an unused substitute, due to a cold and Benitez's wish to give Ryan Bertrand an opportunity.
Reinforcements are available for the Brentford clash.
Demba Ba, ineligible in the Europa League after playing for Newcastle earlier in the competition, David Luiz, suspended against Sparta, and Nigeria duo Victor Moses and John Obi Mikel could feature.
"We have more bodies and hopefully we can manage in a better way," Benitez said.


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My Mother, the late Louise Calhoun, on occasion of introducing me, would always say, "This is my ba-by" as she lovingly put her arm around me. She thought I could do no wrong ( I always have been pretty sneaky!), and she loved and trusted me completely. All four of us kids thought she was a wonderful Momma.
Mary's first "baby" was Jesus. She loved and trusted him and thought he could do no wrong, and, he never did. They were invited to a huge blow out wedding celebration one day that got to rocking so that they ran out of wine. No Wal-Mart to run to - how embarrassing for the host! Mary told Jesus, "They have no wine." He must have picked up her underlying tone of "Do something Jesus, you can fix it!". In essence he replied "Momma, it's not time to do miracles! Leave me alone!" But Mary went to the servants at the party anyway and told them to do whatever Jesus told them to do. Mary's love and confidence in her "baby" was part of what God was doing at the moment. Most everybody knows the rest of the story. Jesus moved with the promptings of the Spirit of God and turned the water into wine and he did fix the problem. We are told this was the beginning of the miracles of Jesus (John 2: 1-11).
Mary and Jesus' had a close relationship. She knew how he came into the world supernaturally. She was with him in his first miracle. She was with him as he died on the cross. And she was among those gathered together on the day of Pentecost when the Spirit of God swept into the room filling all to overflowing. It was her love, support, and confidence in her son that helped to launch him into the most famous ministry in the world and beyond. This is the power of a wise, loving Mom. The miracle of the water to wine lets us know that God cares about and will undertake for every detail of our lives. The Mom involved that day lets us know when you offer love and constant positive reinforcement and support and trust in your "babies", you are laying the foundation of greatness in their lives for whatever they do.
My mother
Jul 8, 2013 at 12:01 AM


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Do you ever feel guilty or judged for your parenting tactics? Have a hard time managing your priorities (kids/work/friends/family)? Are you scrambling to figure out child care for the summer? Feel like you're losing your mind, just a little? This is a safe space for all the questions you've ever wanted to ask.
Use the threads below to vent, confess or ask advice. You're welcome to weigh in, too, and tell other moms if you think they're right or wrong -- or just in that ambiguous gray space called 'being human.'
The Sh*tty Moms will enter the discussion on Friday, June 21 1pm ET | 6pm BST to provide advice and reassurance. In the meantime, you can find them at @ShttyMom
In the past, the Sh*tty Moms have addressed such topics as:
• You're Home with the Kid and You Have a Conference Call in Ten Minutes
• How to Sleep in Until Nine A.M. Every Weekend
• Organized Sports Might Be Great for the Kids but They Suck for You
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I haven't! I actually thought her book was funny. She should try my method of 15 mins of piano for 15 of iPad. So much less yelling.
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text: House Bill Mandates Colleges Make Plans for Network Filteringmatt buchanan2/08/08 7:30pmFiled to: GovernmentGadgetsLawPoliticscollegesHome EntertainmentP2Puniversities28EditPromoteShare to KinjaToggle Conversation toolsGo to permalink I bet you were feeling pretty happy with Congress a little bit ago. Get ready to go back to normal! The College Opportunity and Affordability passed the House today (sounds good so far, right?), but it carries a provision that forces schools to make plans for network filtering mojo and a legal alternative to P2P file-sharing. Luckily, the provision doesn't have much in the way of teeth right now, but an amendment to safeguard schools' federal funding if they don't comply was pulled yesterday, so it could quickly grow some. Just another reminder of why gov't peeps who know tech and aren't easily confused by slick lobbying are important. [Ars Technica] Reply28 repliesLeave a reply


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Trinucleotide repeat disorder
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Trinucleotide repeat disorders (also known as trinucleotide repeat expansion disorders, triplet repeat expansion disorders or codon reiteration disorders) are a set of genetic disorders caused by trinucleotide repeat expansion, a kind of mutation where trinucleotide repeats in certain genes exceed the normal, stable threshold, which differs per gene. The mutation is a subset of unstable microsatellite repeats that occur throughout all genomic sequences. If the repeat is present in a healthy gene, a dynamic mutation may increase the repeat count and result in a defective gene.
Trinucleotide repeats are sometimes classified as insertion mutations[1][2] and sometimes as a separate class of mutations.[3]
Since the early 1990s, a new class of molecular disease has been characterized based upon the presence of unstable and abnormal expansions of DNA-triplets (trinucleotides). The first triplet disease to be identified was fragile X syndrome, which has since been mapped to the long arm of the X chromosome. At this point, there are from 230 to 4000 CGG repeats in the gene that causes fragile X syndrome in these patients, as compared with 60 to 230 repeats in carriers and 5 to 54 repeats in unaffected individuals. The chromosomal instability resulting from this trinucleotide expansion presents clinically as intellectual disability, distinctive facial features, and macroorchidism in males. The second, related DNA-triplet repeat disease, fragile X-E syndrome, was also identified on the X chromosome, but was found to be the result of an expanded CCG repeat.[4] Identifying trinucleotide repeats as the basis of disease has brought clarity to our understanding of a complex set of inherited neurological diseases.
As more repeat expansion diseases have been discovered, several categories have been established to group them based upon similar characteristics. Category I includes Huntington's disease (HD) and the spinocerebellar ataxias that are caused by a CAG repeat expansion in protein-coding portions of specific genes. Category II expansions tend to be more phenotypically diverse with heterogeneous expansions that are generally small in magnitude, but also found in the exons of genes. Category III includes fragile X syndrome, myotonic dystrophy, two of the spinocerebellar ataxias, juvenile myoclonic epilepsy, and Friedreich's ataxia. These diseases are characterized by typically much larger repeat expansions than the first two groups, and the repeats are located outside of the protein-coding regions of the genes.[citation needed]
CAG repeats[edit]
Currently, nine neurologic disorders are known to be caused by an increased number of CAG repeats, typically in coding regions of otherwise unrelated proteins. During protein synthesis, the expanded CAG repeats are translated into a series of uninterrupted glutamine residues forming what is known as a polyglutamine tract ("polyQ"). Such polyglutamine tracts may be subject to increased aggregation.[citation needed]
Recent results suggest that the CAG repeats need not always be translated in order to cause toxicity. Researchers at the University of Pennsylvania demonstrated that in fruit flies, a protein previously known to bind CUG repeats (muscleblind, or mbl) is also capable of binding CAG repeats. Furthermore, when the CAG repeat was changed to a repeating series of CAACAG (which also translates to polyQ), toxicity was dramatically reduced.[5] The human homolog of mbl, MBNL1, which was originally identified as binding CUG repeats in RNA,[6] has since been shown to bind CAG[7][8] (and CCG[8]) repeats as well.
These disorders are characterized by autosomal-dominant mode of inheritance (with the exception of spino-bulbar muscular atrophy, which shows X-linked inheritance), midlife onset, a progressive course, and a correlation of the number of CAG repeats with the severity of disease and the age at onset. Family studies have also suggested that these diseases are associated with anticipation, the tendency for progressively earlier or more severe expression of the disease in successive generations. Although the causative genes are widely expressed in all of the known polyglutamine diseases, each disease displays an extremely selective pattern of neurodegeneration.[citation needed]
At present there are 14 documented trinucleotide repeat disorders that affect humans.[9]
A common symptom of PolyQ diseases is characterized by a progressive degeneration of nerve cells usually affecting people later in life. Although these diseases share the same repeated codon (CAG) and some symptoms, the repeats for the different polyglutamine diseases occur on different chromosomes.[citation needed]
The non-PolyQ diseases do not share any specific symptoms and are unlike the PolyQ diseases.[citation needed]
Repeat count | Classification | Disease status |
<28 | Normal | Unaffected |
28–35 | Intermediate | Unaffected |
36–40 | Reduced-penetrance | May be affected |
>40 | Full-penetrance | Affected |
Trinucleotide repeat disorders generally show genetic anticipation, where their severity increases with each successive generation that inherits them. This is likely explained by the addition of further CAG repeats in the gene in the progeny of affected individuals. For example, Huntington's disease occurs when there are more than 35 CAG repeats on the gene coding for the protein HTT. A parent with 35 repeats would be considered "normal" and never exhibit any symptoms of the disease.[10] That parent's offspring, however, would be at an increased risk compared to the general population of developing Huntington's, as it would take only the addition of one more CAG codon to cause the production of mHTT (mutant HTT), the protein responsible for disease. Huntington's very rarely occurs spontaneously; it is almost always the result of inheriting the defective gene from an affected parent. Sporadic cases of Huntington's do occur, and those individuals with a parent who already has a significant number of CAG repeats in their HTT gene, especially if it approaches the number (36) required for the disease to manifest, are at an increased risk of developing Huntington's despite the lack of any history of the disease in their family. Also, the more repeats, the more severe the disease and the earlier its onset.[10] This explains why individuals that have had Huntington's running in their family for a longer period of time show an earlier age of disease onset and faster disease progression, as mutations that add additional CAG codons become more likely with each successive generation.[10]
Trinucleotide repeat disorders are the result of extensive duplication of a single codon. In fact, the cause is trinucleotide expansion up to a repeat number above a certain threshold level. Huntington's is a good example of this phenomenon, as can be seen in the table on the right.
Why three nucleotides?[edit]
An interesting question is why three nucleotides are expanded, rather than two or four or some other number. Dinucleotide repeats are a common feature of the genome in general, as are larger repeats (e.g. VNTRs - Variable Number Tandem Repeats). One possibility is that repeats that are not a multiple of three would not be viable. Trinucleotide repeat expansions tend to be near coding regions of the genome, and therefore repeats that are not multiples of three could cause frameshift mutations. If the frameshift mutations altered the expression of developmentally obligatory pathways, then non-trinucleotide repeats may be masked by developmental lethality. Mutations of 3 base pairs, on the other hand, do not cause a catastrophic frameshift mutation, and unless a stop codon (TAG, TAA, TGA) is the triplet that is added to the gene - which would in almost all cases render the protein coded for useless - a trinucleotide addition to a gene can have no effect at all on the protein, can cripple the protein, or sometimes can make it work even better than it used to. The overwhelming number of mutations are not beneficial, and this article is testimony to the severely detrimental effects trinucleotide additions to the genome can produce. Still, 3 (and multiples of 3) nucleotide expansions to a coding region of the genome are at least somewhat less likely to be detrimental to an organism as a maximum of two amino acids will be affected, and the reading frame otherwise maintained the same.
This section needs expansion. You can help by adding to it. (May 2008) |
In over half of these disorders, the repeated codon is CAG, which in a coding region, codes for glutamine (Q), resulting in a polyglutamine tract. These diseases are commonly referred to as polyglutamine (or PolyQ) diseases. The remaining disorders repeated codons do not code for glutamine and are classified as non-polyglutamine diseases.
Polyglutamine (PolyQ) diseases[edit]
Type | Gene | Normal PolyQ repeats | Pathogenic PolyQ repeats |
DRPLA (Dentatorubropallidoluysian atrophy) | ATN1 or DRPLA | 6 - 35 | 49 - 88 |
HD (Huntington's disease) | HTT | 6 - 35 | 36 - 250 |
SBMA (Spinal and bulbar muscular atrophy) | AR | 9 - 36 | 38 - 62 |
SCA1 (Spinocerebellar ataxia Type 1) | ATXN1 | 6 - 35 | 49 - 88 |
SCA2 (Spinocerebellar ataxia Type 2) | ATXN2 | 14 - 32 | 33 - 77 |
SCA3 (Spinocerebellar ataxia Type 3 or Machado-Joseph disease) | ATXN3 | 12 - 40 | 55 - 86 |
SCA6 (Spinocerebellar ataxia Type 6) | CACNA1A | 4 - 18 | 21 - 30 |
SCA7 (Spinocerebellar ataxia Type 7) | ATXN7 | 7 - 17 | 38 - 120 |
SCA17 (Spinocerebellar ataxia Type 17) | TBP | 25 - 42 | 47 - 63 |
Non-polyglutamine diseases[edit]
Type | Gene | Codon | Normal/wild type | Pathogenic |
FRAXA (Fragile X syndrome) | FMR1, on the X-chromosome | CGG | 6 - 53 | 230+ |
FXTAS (Fragile X-associated tremor/ataxia syndrome) | FMR1, on the X-chromosome | CGG | 6 - 53 | 55-200 |
FRAXE (Fragile XE mental retardation) | AFF2 or FMR2, on the X-chromosome | CCG | 6 - 35 | 200+ |
FRDA (Friedreich's ataxia) | FXN or X25, (frataxin—reduced expression) | GAA | 7 - 34 | 100+ |
DM (Myotonic dystrophy) | DMPK | CTG | 5 - 34 | 50+ |
SCA8 (Spinocerebellar ataxia Type 8) | OSCA or SCA8 | CTG | 16 - 37 | 110 - 250 |
SCA12 (Spinocerebellar ataxia Type 12) | PPP2R2B or SCA12 | nnn On 5' end | 7 - 28 | 66 - 78 |
Trinucleotide repeat expansion[edit]
This section needs expansion. You can help by adding to it. (September 2011) |
Trinucleotide repeat expansion, also known as triplet repeat expansion, is the DNA mutation responsible for causing any type of disorder categorized as a trinucleotide repeat disorder. These are labelled in dynamical genetics as dynamic mutations.[11]
Triplet expansion is caused by slippage during DNA replication. Due to the tandem repeats in the DNA sequence and the instability of the sequence in these regions, 'loop out' structures may form during DNA replication while maintaining complementary base pairing between the parent strand and the daughter strand being synthesized. In essence, a nick one side of the DNA strand is caused by cleavage by endonuclease whereby the repetitive triplet is extended and sealed by DNA polymerase and DNA ligase, respectively.[12] If the loop out structure is formed from sequence on the daughter strand this will result in an increase in the number of repeats. However, if the loop out structure is formed on the parent strand, a decrease in the number of repeats occurs. It appears that expansion of these repeats is more common than reduction. In general, the larger the expansion the more likely they are to cause disease or increase the severity of disease. This property results in the characteristic of anticipation seen in trinucleotide repeat disorders. Anticipation describes the tendency of age of onset to decrease and severity of symptoms to increase through successive generations of an affected family due to the expansion of these repeats. In 2006, a model of expanding the triplets by involving RNA:DNA intermediate formed in repeat transcription or in post-transcription was proposed,[13] and similar ideas turned to be an ongoing issue of mechanistic studies ever since.[14] [15]
In 2007, a new disease model was produced to explain the progression of Huntington's Disease and similar trinucleotide repeat disorders, which, in simulations, seems to accurately predict age of onset and the way the disease will progress in an individual, based on the number of repeats of a genetic mutation.[16] In 2014, Budworth found success in inhibiting Huntinton in a mouse model. "We describe a mouse model of Huntington's disease that allows us to separate out the effects of the inherited gene from the expansion that occurs during life. We find that blocking the continued expansion of the gene causes a delay in onset of symptoms." [17]
- ^ Types of Mutations Understanding Evolution For Teachers Home. Retrieved on September 19, 2009
- ^ Page 510 in: Genomes 3. Terence A. Brown. Garland Science, 2007. ISBN 0-8153-4138-5, ISBN 978-0-8153-4138-3. 713 pages
- ^ Page 145 in: Title: Genetics of mental disorders: what practitioners and students need to know. Authors: Stephen V. Faraone, Ming T. Tsuang, Debby W. Tsuang. Publisher: Guilford Press, 2001. ISBN 1-57230-739-0, ISBN 978-1-57230-739-1. Length: 272 pages
- ^ "Fragile XE syndrome". Genetic and Rare Diseases Information Center (GARD). Retrieved 14 September 2012.
- ^ Li, L. B.; Yu, Z.; Teng, X.; Bonini, N. M. (2008). "RNA toxicity is a component of ataxin-3 degeneration in Drosophila". Nature. 453 (7198): 1107–1111. doi:10.1038/nature06909. PMC 2574630. PMID 18449188.
- ^ Miller, J. W.; Urbinati, C.; Teng-Umnuay, P.; Stenberg, M.; Byrne, B.; Thornton, C.; Swanson, M. (2000). "Recruitment of human muscleblind proteins to (CUG)n expansions associated with myotonic dystrophy". The EMBO Journal. 19 (17): 4439–4448. doi:10.1093/emboj/19.17.4439. PMC 302046. PMID 10970838.
- ^ Ho, T. H.; Savkur, R. S.; Poulos, M. G.; Mancini, M. A.; Swanson, M. S.; Cooper, T. A. (2005). "Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy". Journal of Cell Science. 118 (13): 2923–2933. doi:10.1242/jcs.02404. PMID 15961406.
- ^ a b Kino, Y.; Mori, D.; Oma, Y.; Takeshita, Y.; Sasagawa, N.; Ishiura, S. (2004). "Muscleblind protein, MBNL1/EXP, binds specifically to CHHG repeats". Human Molecular Genetics. 13 (5): 495–507. doi:10.1093/hmg/ddh056. PMID 14722159.
- ^ Orr, Harry T.; Zoghbi, Huda Y. (2007). "Trinucleotide Repeat Disorders". Annual Review of Neuroscience. 30 (1): 575–621. doi:10.1146/annurev.neuro.29.051605.113042. ISSN 0147-006X.
- ^ a b c d Walker FO (2007). "Huntington's disease". Lancet. 369 (9557): 218–28 [220]. doi:10.1016/S0140-6736(07)60111-1. PMID 17240289.
- ^ Richards, R. I.; Sutherland, G. R. (1997). "Dynamic mutation: Possible mechanisms and significance in human disease". Trends in Biochemical Sciences. 22 (11): 432–436. doi:10.1016/S0968-0004(97)01108-0. PMID 9397685.
- ^ Petruska, J.; Hartenstine, M.; Goodman, M. (1998). "Analysis of Strand Slippage in DNA Polymerase Expansions of CAG/CTG Triplet Repeats Associated with Neurodegenerative Disease". Journal of Biological Chemistry. 273 (9): 5204–5210. doi:10.1074/jbc.273.9.5204. PMID 9478975.
- ^ Pan XF (2006). "Mechanism of trinucleotide repeats instabilities: the necessities of repeat non-B secondary structure formation and the roles of cellular trans-acting factors". Acta Genetica Sin. 33 (1): 1–11. doi:10.1016/S0379-4172(06)60001-2. PMID 16450581.
- ^ McIvor EI, Polak U, Napierala M (2010). "New insights into repeat instability: Role of RNA•DNA hybrids". RNA Biol. 7 (5): 551–8. doi:10.4161/rna.7.5.12745. PMC 3073251. PMID 20729633.
- ^ Salinas-Rios V, Belotserkovskii BP, Hanawalt PC (2011). "DNA slip-outs cause RNA polymerase II arrest in vitro: potential implications for genetic instability". Nucleic Acids Res. 39 (15): 1–11. doi:10.1093/nar/gkr429. PMC 3177194. PMID 21666257.
- ^ Kaplan, Shai; Itzkovitz, Shalev; Shapiro, Ehud (2007). "A Universal Mechanism Ties Genotype to Phenotype in Trinucleotide Diseases". PLoS Computational Biology. 3 (11): e235. doi:10.1371/journal.pcbi.0030235. ISSN 1553-734X.
- ^ Helen Bedworth; Faye R. Harris; Paul Williams; Do Yup Lee; Amy Holt; Jens Pahnke; Bartosz Szczesny; Karina Acevedo-Torres; Sylvette Ayala-Peña; Cynthia T. McMurray (2015). "Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease". PLOS Genetics. 11 (8). doi:10.1371/journal.pgen.1005267. PMC 4527696. PMID 26247199.
External links[edit]
- HOPES: Huntington's Outreach Project for Education, at Stanford
- Trinucleotide Repeat Expansion at the US National Library of Medicine Medical Subject Headings (MeSH)
- GeneReviews/NCBI/NIH/UW entry on DRPLA
- National Institute of Neurological Disorders and Stroke
- Genetics Home Reference
- MicroRNA, trinucleotide repeats and the genetics of general cognitive ability


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Honda will voluntarily recall certain model-year 2012 Accord and Crosstour vehicles in the U.S. to replace a side curtain airbag assembly. An incorrect propellant mixture was prepared when manufacturing the initiator component of the side-curtain airbag inflator. Use of the wrong initiator propellant may result in a failure of the pressurized gas that inflates the side-curtain airbag to be released from the airbag inflator, which in turn would cause non-deployment of the side curtain airbag during a crash. Honda has identified 347 vehicles affected by this problem, and is investigating whether other vehicles also may be equipped with an affected inflator. Honda expects to have all relevant information from its suppliers by February 8, 2012, and will identify any additional affected units by that time. Honda does not expect the total number of affected vehicles to exceed 1,000 units. No crashes or injuries have been reported related to this defect, which was identified during internal production testing by a supplier.
Honda is announcing this recall to encourage owners of all affected vehicles to take their vehicles to an authorized dealer as soon as they receive notification of this recall from Honda. Mailed notification to customers will begin in early February 2012. In addition to contacting customers by mail, in early February, owners of these vehicles will be able to determine if their vehicles require inspection by going on-line to www.recalls.honda.com or by calling (800) 999-1009, and selecting option 4.


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Documentary Chronicles Mexican Drug War
LAS VEGAS - Filmmaker Charlie Minn knows "8 Murders a Day" is not your typical blockbuster hit starring A-List celebrities.
"You're not going to see George Clooney or Brad Pitt in this movie. This is an independent film from the heart that I put my life on the line for," he said.
The film chronicles the drug war erupting in the Mexican border town of Juarez. Lives in Juarez are being lost daily. The bloodshed is brutal as two drug cartels fight a troubling and terrifying turf war.
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Juarez lies across the U.S.-Mexico border from El Paso, Texas. No matter how you count and compare the Juarez death toll, it's disturbing.
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The film makes its Las Vegas debut at Regal Village Square Stadium 18 Friday, December 30.
The theater is located at Sahara Avenue and Fort Apache Road. The documentary will run for one week and may run longer depending on public support.
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