text:
miRBase |
Stem-loop sequence mmu-mir-122 |
Accession | MI0000256 | |||||||||||||||||||||||||||||||||||||||||||||
Previous IDs | mmu-mir-122a | |||||||||||||||||||||||||||||||||||||||||||||
Symbol | MGI:Mirn122a | |||||||||||||||||||||||||||||||||||||||||||||
Description | Mus musculus miR-122 stem-loop | |||||||||||||||||||||||||||||||||||||||||||||
Gene family | MIPF0000095; mir-122 | |||||||||||||||||||||||||||||||||||||||||||||
Community annotation |
This text is a summary paragraph taken from the Wikipedia entry entitled MiR-122. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ... The text in this section is taken from the free, online encyclopedia, Wikipedia. Anyone can edit a Wikipedia page. We hope that experts on particular microRNA sequences will use the links to Wikipedia below to edit the annotation of individual microRNAs, to add information about function, evolution, discovery, and literature references, for example. Any changes that you make will be visible in Wikipedia immediately, and in miRBase within 24 hours. Editing Wikipedia entries is straightforward. If you haven't edited a page before, you might like to take a look at the following Wikipedia help pages: You can also create new pages at Wikipedia about microRNA families that do not currently have specific entries there. Please let us know if you do, so we can incorporate your annotation into miRBase, and create the appropriate links from miRBase entries to the relevant Wikipedia pages. Please note, we're not responsible for the content of Wikipedia pages. You can read more about miRBase, Wikipedia and community annotation on this blog post. Please email us for help or with comments about this community annotation initiative. miR-122 is a miRNA that is conserved between vertebrate species. miR-122 is not present in invertebrates, and no close paralogs of miR-122 have been detected. miR-122 expression is specific to the liver, where it has been implicated as a regulator of fatty-acid metabolism in mouse studies. Reduced miR-122 levels are associated with hepatocellular carcinoma. miR-122 also plays an important positive role in the regulation of hepatitis C virus replication.
miR-122 is a miRNA that is conserved between vertebrate species. miR-122 is not present in invertebrates, and no close paralogs of miR-122 have been detected.[1] miR-122 expression is specific to the liver, where it has been implicated as a regulator of fatty-acid metabolism in mouse studies. Reduced miR-122 levels are associated with hepatocellular carcinoma. miR-122 also plays an important positive role in the regulation of hepatitis C virus replication. ContentsExpression and regulationmiR-122 was originally identified by cloning of tissue-specific microRNAs in mouse, where its expression is restricted to the liver.[2] The liver-specific expression of miR-122 is conserved in zebrafish.[3] miR-122 expression increases during embryogenesis until it constitutes 72% of total miRNA in adult human liver, making it one of the most highly expressed miRNAs in any tissue.[4] In humans, miR-122 is encoded at a single genomic locus in chromosome 18. The primary miR-122 transcript (pri-miR-122) is a long non-coding RNA. Transcription is regulated by HNF4α.[5] The miR-122 hairpin precursor consensus shown here is predicted based on base pairing and cross-species conservation. The mature sequence is excised from the 5' arm of the hairpin.[2][6] There is evidence that miR-122 is regulated by Rev-ErbA alpha which is involved in circadian gene expression, suggesting that miR-122 is a circadian metabolic regulator. miR-122 regulates the expression of several mRNA molecules that are important in the circadian cycle, such as PPARβ/δ.[7] Mature miR-122 is subject to modification by the poly(A) polymerase GLD-2, which adds a single adenosine to the miRNA 3' end. This results in an increase in miR-122 stability.[8] miR-122 targetsmiR-122 regulates the synthesis of the protein CAT-1 by binding to sites in the mRNA 3'UTR such that translation is repressed and the mRNA is targeted to P bodies. This repression can be relieved by the protein HuR, which is released from the nucleus under conditions of cell stress and binds to the CAT-1 3'UTR. The HuR interaction leads to release of the mRNA from the P bodies and resumption of active translation.[9] A number of other miR-122 targets, including CD320, AldoA and BCKDK, have been identified by microarray analysis of changes in mRNA expression in the liver of mice treated with miR-122 inhibitors.[10][11][12] The overall effect of miR-122 inhibition is to reduce the plasma cholesterol level, although the pathways involved in this regulation have not been fully elucidated. miR-122 also regulates systemic iron homeostasis via the target mRNAs Hjv and Hfe.[13] miR-122 inhibition in mice or primates does not result in any detectable liver toxicity.[14] Role in cancermiR-122 levels are frequently reduced in hepatocellular carcinoma (HCC) compared to normal liver, and low miR-122 levels correlate with poor prognosis.[15][16] Overexpression of miR-122 reduces tumorigenic properties in HCC cell lines, suggesting that it functions as a tumor suppressor gene, and increases the response of cells to the chemotherapeutic drugs sorafenib and doxorubicin.[17][18] Several miR-122 target genes have been implicated in tumorigenesis, including ADAM10, IGF1R, CCNG1 and ADAM17.[17][18][19] Regulation of HCVRecent studies have shown that replication of hepatitis C virus (HCV) is dependent on miR-122 expression.[20] miR-122 regulates HCV by binding directly to two adjacent sites close to the 5' end of HCV RNA.[21] Although these experiments were conducted using genotype 1a and 1b HCV RNA, the miR-122 binding sites are highly conserved across different genotypes, and miR-122 is also required for replication of infectious type 2a HCV.[22] As miRNAs generally function to repress gene expression by binding to 3'UTR sites, this positive regulation of viral replication via a 5'UTR represents a novel function for miR-122. The mechanism of regulation is not yet clear. miR-122 stimulates translation of HCV RNA, but not to a sufficient extent to explain its effects on viral replication, indicating that a second stage of the viral replication cycle must also be regulated.[23][24] HCV RNA synthesis is not affected by miR-122, suggesting that regulation of other processes such as RNA stability may occur.[25][26] The extent to which the miRNA-induced silencing complex (miRISC) is involved in this regulation has not been fully determined. The Argonaute proteins (Ago1-4), which are essential for miRNA-directed repression, appear to be necessary for miR-122 to regulate HCV,[27] although miR-122 overexpression may overcome this requirement.[28] Another miRISC component, the DEAD-box RNA helicase DDX6, does not play a role in miR-122-facilitated HCV replication.[29] The existing HCV therapy of PEG-IFNα plus ribavirin is poorly tolerated and frequently ineffective, so there is an urgent need for new drugs, and miR-122 inhibitors are an attractive possibility. The association between low miR-122 levels and hepatocellular carcinoma suggests that caution will be necessary when testing miR-122 inhibitors, and that long term treatment might be undesirable. However, miR-122 is a promising target as it can be very selectively and effectively inhibited with antisense oligonucleotides, and as it is a conserved host factor it is hoped that the virus would not be able to acquire resistance mutations to an anti-miR-122 therapeutic. Inhibitor - MiravirsenSantaris Pharma have developed a locked nucleic acid-based antisense oligonucleotide that is delivered to the liver and effectively inhibits miR-122 following intravenous injection without inducing liver toxicity.[30] This molecule reduced HCV viremia in a small-scale trial in chimpanzees.[31] The inhibitor is known as miravirsen and is in phase II clinical trials with the results expected in early 2012.[32] Miravirsen is currently undergoing Phase IIa trial with preliminary data presented on November 2011 at The Liver Meeting showing promising results from a group of chronic HCV genotype 1 infection patients. Patients were randomly assigned to placebo groups or one of the three multiple ascending dose groups (3 mg/kg, 5 mg/kg, 7 mg/kg of miravirsen). The naïve patients were given 5 weekly doses of miravirsen via subcutaneous injection for four weeks, and 4 out of 9 patients receiving the highest dose (7 mg/kg) exhibited significant decrease in Hepatitis C virus RNA (p<0.001). The result was sustained even 10 weeks after the last miravirsen administration.[33] Further trials testing for the safety and pharmokinetics of miravirsen will also be conducted in other countries such as Germany and Netherlands.[32] Final results are being presented in April 2012.[34][35][36][37] Use as a BiomarkermiR-122 has recently been explored as a potential biomarker for various hepatic conditions. A change in levels of miR-122 in the blood has been confirmed as an indicator for liver disease.[38][39] This change is noted before increased amino-transferase activity, making it a preferable indicator for liver disease. This study also suggested that miR-122 could be a "novel, predictive and reliable blood marker for viral-, alcohol- and chemical-induced liver injury." [5] There is a great deal of research into the use of miR-122 as a biomarker for Hepatitis C. While some studies dispute its efficacy for diagnosing Hep C,[40] other research indicates that it may be useful in diagnosing specific forms of Hepatitis. For instance, decreased levels of miR-122 have been linked to a strain of Hepatitis C that is resistant to interferon therapy.[41] In this case, measuring miR-122 levels in the bloodstream of Hepatitis C positive patients would enable more accurate and personalized therapy for their disease. miR-122 has also been suggested as a biomarker for hepatectomy-induced liver injury in patients with hepatocellular carcinoma. [42] References
Further reading[1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] [31] [32] [33] [34] [35] [36] [37] [38] [39] [40] [41] [42]
External links
Stem-loop |
gg c - uc 5' agcugu aguguga aaugguguuug ug c |||||| ||||||| ||||||||||| || a 3' ucgaua ucacacu uuaccgcaaac ac a aa a u caGet sequence |
Deep sequencing |
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Confidence |
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Comments |
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. |
Genome context |
Database links |
Mature sequence mmu-miR-122-5p |
Accession | MIMAT0000246 |
Previous IDs | mmu-miR-122a;mmu-miR-122 |
Sequence |
6 - uggagugugacaaugguguuug - 27 |
Deep sequencing | 3645478 reads, 83 experiments |
Evidence | experimental; cloned [1-2], Illumina [3-4] |
Validated targets |
Predicted targets |
Mature sequence mmu-miR-122-3p |
Accession | MIMAT0017005 |
Previous IDs | mmu-miR-122* |
Sequence |
41 - aaacgccauuaucacacuaa - 60 |
Deep sequencing | 913 reads, 24 experiments |
Evidence | experimental; Illumina [4] |
Predicted targets |
References |
1 |
"Identification of tissue-specific microRNAs from mouse"
Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T
Curr Biol. 12:735-739(2002).
2 |
"A mammalian microRNA expression atlas based on small RNA library sequencing"
Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M
Cell. 129:1401-1414(2007).
3 |
"MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing"
Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A
Mol Hum Reprod. 16:463-471(2010).
4 |
"Mammalian microRNAs: experimental evaluation of novel and previously annotated genes"
Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP
Genes Dev. 24:992-1009(2010).
Comments, questions? Email firstname.lastname@example.com


text:
Subject: | Re: surname |
Author: | Joel Hammer (guest, 188.8.131.52) |
Date: | July 19, 2003 at 9:25:57 PM |
Reply to: | surname by alex |
When I looked in my Spanish dictionary, I found that the word quintero meant: farmer, farmworker. I don't know the exact meaning of the name, but perhaps it would have something to do with a farmer or farmworker.
Because this message is archived you cannot respond to it. |
Messages in this thread: |

subset: commoncrawl


text:
Hi There, I've recently installed ispc3 following the perfect server howto (lenny) and although not every part of the new panel strikes me as absolutely logical or intuitive it seems to be working quite nicely. My only trouble with the whole setup is this: What do all those spamsettings/policies do ? Is there any documentation on those settings ? And secondly, I'm not sure whether spamassassin is doing anything or where I should change/add header insertions. I had headers like X-Spam-Level and X-Spam-Score in every e-mail delivered to my older ispc2 system. No such headers are inserted on the new ispc3 system though. How or where is ispc3 configged to do anything and especially anti-spam tools ? other than that.. great work guys! cheers, Michel
Well.... u shoul use the "normal" policy for anti-spam..... and so the spam dont get throught u shoul do this... edit /etc/amavis/conf.d/50-user locate $final_spam_destiny = D_PASS; change it to : $final_spam_destiny = D_DISCARD; then restart amavis : /etc/init.d/amavis restart i think that should do the trick Hope it helps
thank you robilaur. Though I'm actually not looking for instructions on how to discard any spam. What I am looking for is some documentation or explanation on what is configured by ispconfig so I can change that if it doesn't work. I've done some testing yesterday and it seems anti-spam tools are working as long as they are policies on e-mail domains. I was trying to force policies onto e-mail boxes. The latter just doesn't work. Changing the spam policy to not filtering at all on a box has no effect either when a domain is filtered. Quite annoying since that way it's more or less impossible (at least through the ispc system) to non-filter a postmaster or root account on a domain that's filtered.


text:
Basiron, Anida Suharti@Ami Ronida (2009) Project risk factors : case study of Ministry of Education projects. Masters thesis, Universiti Teknologi Malaysia, Faculty of Civil Engineering.
- Submitted Version
672kB | |
58kB | ||
62kB | ||
49kB |
Risks are inherent in any projects. A major criticism of the Ministry of Education (MOE) projects undertaken by the Public Works Department (PWD) is the growing rate of delays and cost overrun in project delivery. As reports under the JKR Project Information System, (SKALA JKR), as of September 2008 there are three hundred and fifty nine (359) MOE projects were granted extension of time (EOT) and twenty three (23) projects were not completed in a timely manner due to the poor risk anticipation. The aim of this study is to investigate risk factors in building construction projects belonging to MOE. In order to achieve this aim, three objectives have been outlined in this study; to establish risk factors in building project belonging to MOE, to identify the levels of risk of each risk factor from the contractors' perspective and to identify the risk treatment for each risk factor from the contractors' perspective. Postal questionnaire surveys were used as the main data collection method. From the comprehensive assessment of the likelihood of occurrence and their impacts, this study identifies ten major risk factors where "affordable material is more expensive than presented in bills of quantity (BQ)" factor was found to have significant impact on the project during its life cycle. This study also found that each risk factor can be treated by reducing its impact if the risk occurs. Treatment includes contingency planning that should address significant risk areas through some form of tactical response. The adoption of a risk management technique for building projects belonging to the MOE is critical to ensure the successfulness of the future project implementation.
Item Type: | Thesis (Masters) |
Additional Information: | Thesis (Sarjana Sains (Pengurusan Pembinaan)) - Universiti Teknologi Malaysia, 2009; Supervisor : Ir. Dr. Rosli Mohamad Zin |
Uncontrolled Keywords: | engineering, safety measures, reliability (engineering), project management |
Subjects: | T Technology > TA Engineering (General). Civil engineering (General) |
Divisions: | Civil Engineering |
ID Code: | 12687 |
Deposited By: | INVALID USER |
Deposited On: | 22 Jun 2011 09:12 |
Last Modified: | 07 Aug 2012 06:40 |
Repository Staff Only: item control page


text:
Kate Winslet and 'Labor Day' come to Mansfield
Crews with the movie "Labor Day" filmed scenes at Benny's in Mansfield yesterday. Locals who gathered in front of the retailer were able to see the star of the drama, Kate Winslet, in the parking lot. Some tweeted photos from the scene. Boston Casting employees had put out word earlier in the day that they were on the hunt for cars from the late '70s and early '80s for the film. "Labor Day," which has been shooting in Shelburne, also stars Josh Brolin.
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text:
Something's Gotta Give
Thursday, February 10, 2011
Five Favorite Flicks
Something's Gotta Give
26 comments:
- The Casual Classic said...
I can watch these over and over:
Dirty Dancing
Field of Dreams
Sweet Home Alabama
Dazed and Confused
Tombstone - February 10, 2011 at 8:22 AM
- CLP said...
My Top 5 would be:
Father of the Bride
Home Alone
The Sound of Music
The Diary of Bridget Jones - February 10, 2011 at 8:46 AM
- Dex said...
You should really check out "Making the grade" if you can get your hands on a copy.
- February 10, 2011 at 8:47 AM
- CLP said...
My top 5 are:
Father of the Bride
Home Alone
Guess Who's Coming to Dinner - February 10, 2011 at 8:50 AM
- Michie said...
The Proposal is a movie I will never tire of! Lovely wardrobe for Sandra Bullock, a fabulous vintage boat, a beautiful setting, lots of laughs and a happy ending-- love it!
- February 10, 2011 at 8:51 AM
- Whitney and the Preppy Puppy said...
I just watched Taken the other night and really liked it. Not a top five, but good if you're looking for a little action. I also get sucked in to HBO and Showtime documentaries. Not the most uplifting, but most of them are terrific. Some of my favorites are Nursery University, Boy Interrupted, Jockey, Barbaro, The Lazarus Effect (I like this b/c of my hubby's AIDS work in Africa), The One Percent, and Sweethearts Of The Prison Rodeo.
- February 10, 2011 at 9:57 AM
- j.mosby said...
Don't forget Whit Stillman's "Metropolitan", "Last Days of Disco", "Barcelona", Matt Damon in "School Ties" and "White Squall" with Jeff Bridges. Lastly Sandra Bullock's "Blind Side". Hope you'll agree!
- February 10, 2011 at 10:05 AM
- eas said...
I adore these:
Mary Poppins
The Parent Trap
Breakfast at Tiffanys
From Russia With Love - February 10, 2011 at 10:25 AM
- Buckhead Belle said...
Those are some of my favorites also! So funny... I just answered this in a questionnaire I was tagged in. Totally wanting to curl up and watch Wall Street right about now...
- February 10, 2011 at 10:26 AM
- MCW said...
Shawshank Redemption and Love Actually are two of my all time favorites. I need to see Wall Street!
- February 10, 2011 at 10:31 AM
- Main Line Sportsman said...
Godfather, Jaws,Pope of Greenwich Village, My Favorite Year, The Quiet Man.
- February 10, 2011 at 11:50 AM
- Summer is a Verb said...
Something's Gotta Give is def one of my top five too. It's the director Nancy Meyers. She has faaabulous taste and always films in theee BEST locales. A bit of a francophile to boot. Merci for the tag EAS. Just give me a week or 2 to get out from behind the tag ball and come up w/5 not already mentioned favs...XXOO
- February 10, 2011 at 11:53 AM
- LoneStarPrep said...
Great list you compiled! Shag, You've Got Mail, Mona Lisa Smile, and Sweet Home Alabama are my faves.
- February 10, 2011 at 12:27 PM
- Preppy and Proud of it! said...
I love Something's Gotta Give! My other 5 five favorites are Father of the Bride (with Steve Martin), Parent Trap (the Haley Mills one). Dead Poets Society, Wedding Date and Sweet Magnolias. Thanks!
- February 10, 2011 at 1:13 PM
- Katie said...
Thank you so much for stopping by my little piece of the web! Hope you'll come back soon!
- February 10, 2011 at 1:54 PM
- Katie said...
Oh yeah! My top 5 go-to comfort movies: Finding Nemo, Sabrina, Legally Blonde, You've Got Mail, and Ever After ... I know each one of 'em by heart!
- February 10, 2011 at 1:56 PM
- The Aly Way said...
Father of the Bride Series
Practical Magic
Legends of the Fall
Tristan and Isolde
Pride and Prejudice - February 10, 2011 at 4:28 PM
- Preppy 101 said...
I'll do it darlin'. Thanks for the tag. You have great picks!! xoxo
- February 10, 2011 at 4:42 PM
- Maryland Magnolia said...
The only movie I've see out of your 5 faves is You've Got Mail. I'm going to have to check some of the others out :)
My Top 5:
1. Enchanted April
2. About a Boy
3. Pride and Prejudice
4. Anne of Green Gables
5. Love Actually - February 10, 2011 at 4:54 PM
- Sarah @ Cubicle Sanity said...
I love how you tag other bloggers. It is such a great way for people like me who just found you to find other fabulous blogs to add to my never ending list!! Cute cute!
Incase you were wondering...here are mine:
1. The Way We Were
2. Romey and Michelle's Highschool Reunion
3. Pride and Prejudice (could watch Darcey all day long)
4. Lady and The Tramp
5. Twilight (sorry, had to do it) - February 10, 2011 at 5:55 PM
- Wendy said...
Great list! Several would grace my top 5 too.
- February 10, 2011 at 6:40 PM
- Emily said...
Oooh, great choices! Here are my favorites:
1. Bridget Jones's Diary
2. Caddyshack
3. National Treasure I and II
4. Sliding Doors
5. Four Weddings and a Funeral - February 10, 2011 at 9:08 PM
- Tammy B said...
My go to movies are:
You've Got Mail
Making the Grade
Legally Blonde
Trading Places
St. Elmo's Fire
Runner ups:
Bridget Jones Diary
Mona Lisa Smile - February 10, 2011 at 10:20 PM
- Kappa Prep said...
Just posted your tag!
- February 11, 2011 at 4:42 PM
- The enchanted home said...
Just found your blog...how fun! We have so much in common when I read about you then I saw your movie list and realized we are meant to be blog friends! Somethings gotta give is one of my tops, I have seen it a dozen times and never tire of it...Nancy Meyers can do no wrong! Then You;ve got mail...another fave and Wall Street, a classic! Just watched it 2 days ago while in bed with the flu....netflix to the rescue! Am your newest follower....please visit me, started a new blog about a month and half ago about the building of our new home and my love for decor and design....also doing my first ever giveaway, a gorgeous french chair!
www.theenchantedhome.blogspot.com - February 13, 2011 at 8:23 AM
- Trish said...
Hey there gorgeous gal, and a million thank you's for the fun tag, promise I will play along this week! :)
LOVE all your faves, Wall Street and You've Got Mail are definitely part of my Top 10 too - LOVE the freshly sharpened bouquet of pencils quote from You've Got Mail...so cute!
Hugs and xxx! - February 13, 2011 at 11:40 PM


text:
This is a summary. To read the whole story subscribe to BostonGlobe.com
TORONTO — At 13:06 of overtime, David Krejci slipped an off-wing shot past James Reimer to give the Bruins a 4-3 win over the Maple Leafs in Game 4. The Bruins lead the series, 3-1. It was Krejci's third goal of the night.
Nathan Horton absorbed a heavy hit from Dion Phaneuf in the defensive zone before Krejci's goal.
The Bruins and Maple Leafs went into overtime for the first time in the series. The game was tied, 3-3, after 60 minutes.
Neither team scored in the third period, although both had chances. The Bruins had a heavy flurry late in the third when James Reimer was caught out of his net. Horton could have scored the go-ahead goal, but couldn't get a shot on net.
The Leafs lost Mark Fraser at 7:49 of the third. Milan Lucic hit Fraser in the face with a slap shot. Fraser, who does not wear a shield, did not return.
The Bruins, down, 2-0, after 20 minutes, roared back for three straight goals in the second period to claim a 3-2 lead.
The Bruins started their rally at 0:32. They were on the power play following a Leo Komarov charging penalty in the last minute of the first.
Reimer stopped a Zdeno Chara point shot. But Patrice Bergeron was in position to slam home the rebound to give the Bruins their first goal. It was Bergeron's first goal of the series.
The Bruins tied the game at 12:59. Again, Reimer left a rebound that the Bruins poked home. Reimer made the first save on a Brad Marchand snap shot but couldn't handle the shot cleanly. Krejci brushed off Mikhail Grabovski's backcheck and crashed the net, banging in the rebound to tie the game, 2-2.
The Bruins completed their three-goal outburst at 16:39 with their second power-play goal of the period. Chara started the play by sending the puck into the offensive zone and rimming it around the wall. Horton rolled over the boards and tracked down the puck. Horton walked the puck off the wall, cut into the middle, and spotted Krejci with his stick ready to shoot on the other side of the ice. Krejci winged a sharp-angle one-timer over Reimer to give the Bruins a 3-2 lead.
But Toronto halted the Bruins' momentum. Forty-four seconds after Krejci's goal, Clarke MacArthur scored his first of the series. Johnny Boychuk had a chance to clear the puck, but MacArthur got to it first and whistled a shot between Tuukka Rask's pads at 17:23. MacArthur was a healthy scratch in Games 2 and 3. His strike was the first goal by one of Toronto's bottom-six forwards in the series.
The Leafs could have taken a lead into the third period. Krejci was called for roughing at 18:12. Then Gregory Campbell was sent off for slashing at 19:19, giving the Leafs a two-man advantage for the remainder of the second. Bergeron, Chara, and Dennis Seidenberg kept the Leafs from scoring the go-ahead, five-on-three goal.
The Leafs grabbed a 2-0 lead in the first period, striking first at 2:35. Phil Kessel started the play by wheeling around the net with the puck. As Kessel looked for options, Tyler Bozak went to the front of the net. Chara and Wade Redden got tangled up trying to cover Bozak, and Joffrey Lupul found an opening in the high slot, taking advantage of Chara and Redden being positioned too close to the net. Kessel connected with Lupul, who snapped the puck past Rask to give the Leafs a 1-0 lead. It was Lupul's team-leading third goal of the series.
The Leafs doubled their lead at 18:32. Kessel and Lupul were involved again. Kessel started the play by rushing the puck through the neutral zone and firing a shot on goal. Rask kicked it to the corner, where Lupul tracked it down, got free of Chara, and found Fraser at the left point.
Fraser then slid the puck to partner Cody Franson at the right point. Franson floated a soft-moving shot on goal that Rask appeared to lose sight of because of a Chara screen. Before Rask could react, Franson's shot had fluttered past him to give Toronto a 2-0 lead.
The Bruins got a late power play to close out the first after Komarov was called for charging. On the power play, Lucic hit the deck and a deflected puck off Chara's stick caught Lucic in the side of the head. A bloody Lucic got up slowly and walked to the room without assistance while holding a towel to his face and he returned for the start of the second period.
The Bruins were inches away from tying the game at 1-1 at 14:45. Marchand sent a cross-ice pass to Krejci. With Reimer down and out, the net was wide open. But Krejci bonked his shot off the left post.


text: South Carolina Car InsuranceDirect Auto Insurance is a leading provider of low cost car insurance in South Carolina and we encourage drivers who have been turned down by other South Carolina car insurance companies to apply for coverage with us. We also offer flexible payment plans that can be adjusted to coincide with your pay days1, as well as coverage options tailored to fit your needs. At Direct, you can get a free quote on affordable car insurance online, by phone, or in a nearby store. Other insurance companies may refuse coverage for issues like a low credit score or a poor driving history. We think everyone deserves a second chance, which is why we work hard to get you the right insurance coverage at the best price possible even if you've had a few slip-ups in the past.2


text:
Comfy House with Terrace (Ornella)
숙박 가능인원2
침실 수1
면적30 m²
Floor No.
- 에어콘
- 인터넷
- 수건
- 부엌
Accommodation summary
주소 | Ippodamou, 85100 Rodi, 그리스 |
숙소유형 | 아파트 |
The house has its own exclusive access to an elegant staircase and consists of a spacious bedroom with four-poster bed, a large kitchen with accessories and appliances, a bathroom with shower and a large terrace overlooking the medieval town. Due to its location, the house is cool and airy, however, in case of need, you can use a good air conditioning system.
The terrace allows you to relax, sunbathe, or outdoor dining. The house is fully furnished and equipped with linen and towels. Weekly cleaning included in the price and Free WI-FI.
You can consult us for any need. We live within walking distance.Near the house, outside the gate to the old city, there is a large parking area with the taxi station and close every Thursday morning, a fine traditional market where you can find fresh fruits and vegetables directly from producers.
A great homemade pastry, just below the house, you can enjoy its products with breakfast served in your room.
Restaurants, bars, traditional bars, taxi rank, bus to the beaches, the harbor or around the island: everything is close and convenient.
And then, starting every morning from Casa Ornella, you will discover many other wonders of the magical island of roses.
More Things to Highlight
In your home you will find as a welcome gift a bottle of fine wine greek, a selection of Greek recipes and a guide on the best restaurants on the island.
조건사항 |
체크인 | 조정가능 |
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The flat was beautiful but quite plain with the standard of equipment. Having two floors, the stairs were a bit awkward.
We really enjoyed our stay in this comfortable apartment. The terrace was cool and we had breakfast and relaxed well in the evenings. The apartment is well situated next to a lovely bakery and people in Rodos are friendly, warm and welcoming.
This is an ideal apartment for a couple or a couple with a child. Very welcoming and friendly hosts. The apartment is located very well - in the old town, but away from the main number of tourists, so not very noisy. On the ground floor there is a small snack bar, which serves a traditional Greek sandwiches, delicious desserts and good coffee. Near the souvenir shops and tavernas (5 minutes walk). Near the gate to New City - access to the street where you can park a car or a scooter and a petrol station with a car wash BP.
Recommend this appartment as very good.
p.s. First use a service Wimdu - loved it! We plan to use it in the future.
Es war eine sehr schöne Woche auf Rhodos. Wir haben uns in der Wohnung sehr wohl gefühlt und hätten nicht anderswo als in der Innenstadt von Rhodos wohnen wollen. Die Wohnung ist sehr hübsch eingerichtet und die Gastgeberin sehr freundlich. Wir würden jeder Zeit wieder dort wohnen, wenn wir auf Rhodos fliegen. Vielen Dank nochmal und...bis bald.
Stéphanie und Christoph
- 확인된 숙소의 품질
- 모든 호스트는 전화로 입증되었습니다.


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The line of people at the stairs leading down to the Great Hall at Cooper Union in lower Manhattan formed early and turned into an audience of 500. They came to hear prominent Mexican and U.S. writers and free expression advocates assess, denounce, and seek solutions to the wave of violence wracking Mexican media.
As the lights dimmed, the Tuesday evening event began with Paul Auster, voice gloomy, reading from an English translation of the desperate editorial on the front page of El Diario. "What do you want from us?" the paper asked of drug traffickers in the piece, published in September, a day after the Ciudad Juárez daily lost another staff member to the power of the gun. "You are the de facto authorities in this city, since our legitimate representatives have been unable to prevent our colleagues from being killed." As with most journalist murders in Mexico, last month's slaying of El Diario's Luis Carlos Santiago is far from being solved.
Rocío Gallegos, a journalist with El Diario, joined a panel discussion with Carmen Aristegui (CNN en Español) and José Luis Martínez (Laberinto), and moderated by Julia Preston (The New York Times). Gallegos pointed out that her paper is seeking a truce, not a surrender, and pointed out that the latter would mean giving up her paper's right to report. "We want to know what is happening and why," she said.
Citing examples of impunity that leave drug cartels free to dictate what information can reach Mexicans and the world, the journalists sought to elaborate on their situation and explore solutions. They emphasized that the problem is not contained to Mexico, pointing to the United States as a primary market for drug consumption and key provider of arms used by the drug traffickers.
More than 30 journalists have been murdered or have gone missing since December 2006, when President Felipe Calderón Hinojosa came to power. CPJ has confirmed that at least eight of these journalists were killed in reprisal for their work.
A joint delegation to Mexico from CPJ and the Inter American Press Association last month resulted in a pledge by Mexican President Felipe Calderón Hinojosa to push for legislation that would make attacks on journalists a federal crime.
Here is what CPJ Executive Director Joel Simon reported to the audience in his opening remarks:
The Mexican federal government has an obligation under its own constitution to ensure freedom of expression; it also has an obligation under international law. But beyond the legal niceties, there is the more practical and prosaic issue that the drug traffickers and criminals are dictating what information is available to the public in Mexico and the global public, represented by all of you here tonight. That's an intolerable situation, one that cannot be allowed to stand.
The event also included readings by, Don DeLillo, Laura Esquivel, Francine Prose, along with poets Víctor Manuel Mendiola and Luis Miguel Aguilar. It was co-sponsored with PEN and PEN Mexico with the support of the John S. and James L. Knight Foundation, which was represented by José Zamora, who has a personal understanding of anti-press violence. Zamora's father, José Rubén Zamora, an investigative journalist with Guatemalan daily El Periódico, was once kidnapped in retaliation for his reporting.
- October 21, 2010 12:50 PM ET
- Short URLhttps://cpj.org/x/3f5c
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Defiance is TrionWorlds new Third Person Shooter MMO…
Defiance has been out for a little while now which has allowed us to play the game since various patches have been applied. It's safe to say that now the experience is pretty robust and consistent. So let's discuss and break down the experience we have enjoyed thus far!
Firstly, we have been playing the PS3 version and we can't vouch for how the Xbox or PC version performs. In addition whichever edition you boot up, be prepared as you should expect multiple updates and patches when you first put the game into the machine. It's an MMO and these patches are ongoing, so be prepared. This isn't a problem with the game, but the genre, and as this game is designed to reach out to those who have never played an MMO it's something be aware of. We are not discussing small updates, as with Battlefield or Black Ops, but large downloads. Those of you with fast broadband or fibre will be fine of course.
The game itself is set in a universe, which is also currently being explored in a new SyFy tv series. It's set on Earth after a a devastating war between Humans and Invading/immigrating aliens. There is now a basic truce between the alien and human survivors. The two story arches overlap to some degree and events in the game can affect the outcome of the tv series. For example there will be missions in the game featuring characters from the TV show, and sometimes there will be events in the game which can effect the show's story line. Your character could even end up featuring in the show based upon your actions in the game. However as the game is in the San Francisco bay area and the tv show in St Louis, there is only so much one can affect the other.
So now to the actual game itself. Lets break it down in parts. The game plays as a third person shooter. So is it a GOOD third person shooter? Well, firstly there is no cover system, as in Gears of War or Uncharted. What there is though, is a nice crouch dynamic and a landscape is full of cover, hills, rocks and buildings. Hiding behind them or under the crest of a hill really will allow you to avoid taking damage. The shooting itself is satisfying, and there is a huge range of weapons to utilise.
There are vehicles too, which you'll need as the gameworld is pretty huge. You can call them at will, and they appear out of nowhere, like a mount in World of Warcraft. The vehicle's controls are little wonky as far as I'm concerned. They are not broken though, and they will probably be improved with patches as time goes on. Movement on foot is fine, and you can sprint at a fair pace (faster if using some of the 'EGO' enhancements), however it is strange that you can fall from any hight and not take any damage. This breaks the 'real world' feel a little and takes you out of the game.
Missions vary, but generally involve going from point A to point B, securing a location by killing anything in site, and then holding down the square button over an object to fix it, open it, close it, switch it on etc. However, the missions in Defiance are there to allow you to level up, explore the world and more importantly expose more of the story. Remember this is a game with a strong narrative, alongside it's TV relative, and the missions are there to allow you to progress through the story arc, timelines and character relationships.
You can customise your character by choosing from a range of classes. In addition you can choose certain 'powers', such as speed and cloaking amongst others. As you progress you can enhance and unlock more powers by utilising the skill tree. As you progress through the game you'll get loot, and weapons. Shields, guns (lots of guns – it's a bit like Borderlands in that respect) all of which encourage you to play that little bit more, and carry out one more mission.
There is a PVP mode. It's like a discrete competitive multi-player mode. There is a domination mode alongside a team deathmatch type experience. Both are worth checking out, and as the computer AI is generally quite weak (with the game utilising swarming as a way of upping the challenge) it makes a nice change of pace fighting other people.
The main game features many co-op levels, and co-op in this game works very organically. For sure you can join a guild/clan, and plan and help each other. However, you can also just tag along to events happening around you, the most thrilling being when an 'arkfall' event takes place. This is when a kind of power source falls from the heavens triggering an intense battle between the players and mutant alien creatures. Should you stumble across one of these you'll be sure to find many other players at the same point, working together.
Visually the game is nothing special. In many respects one feels that this is a game which would really benefit from the 'next gen' consoles. The graphics though are serviceable, and the cut scenes good enough to convey the story, alongside some decent voice acting. The weak link with the voice acting is your 'AI companion' EGO who is a pain in the butt, and ranks alongside Jar Jar Binks as the most annoying fictional character ever.
For those who have always wanted to play a MMO, but just couldn't hack how MMOs played, this is a great, vast story driven game which is a blast to play. It's not particularly excellent in any area, gameplay, graphics, sound etc but it manages to draw you in. Watch the tv show, either weekly, or the opening two parter (which was free on PSN at the time of writing) and it'll help create a nice backstory and add atmosphere to the events in the game. DCUO promised a degree of third person action, set in a MMO framwork on consoles (well on the PS3), but it still largely had traditional MMO fighting and controls. Defiance makes you feel that you are winning and losing due to your shooting skills with the powers and enhancements being just that – enhancements. They don't swing the game too much in the favour of someone with 100 hours in the game. Even a newbie can join in and make a difference, or compete in PVP without feeling that they have to do another 30 hours of grinding before they can join in.
All in all I've enjoyed Defiance, and will stick with the game. I'll want to level out the character and see how the story develops. It's not game of the year, but it's something I can sink my teeth into and feel I'm being rewarded for the time I put in. We recommend Defiance if you like sci-fi, shooting and have always fancied playing an MMO but just couldn't put up with the controls and grinding.


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577. originalLT
4:08 PM GMT on October 25, 2009Hi Blizz and all, Beautiful here in SW CT. after almost 2" of rain. No water in my basement, that's amazing! I guess putting a tarp over my bilco doors worked! Blizz , one more thing about the W.C., did you say they are going to show movies? Wow, thats really going off the deep-end. That's terrible.I wonder what guys like Cantore and Dr. Steve Lyons really think about this and the whole direction that station is taking. I guess they can't say much, they don't want to lose their jobs. Those are the two guys I do like on the station. |


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REPOUSSE Silver TEAPOT English -ANTIQUE-
Click thumbnails for expanded view.
- $295.00
- Item Not Available
Stunning English Silver plate teapot. High detailed repousse leaves grown up from the base. Chasing gives them a luster look. The domed lid is topped with a very pretty rosebud finial.
Stamped SEP with an unidentified maker's mark and model number 1310.
Circa mid to late 19th C
Measures 9 inches handle-to-spout, 7 inches tall
Very Good overall condition. No dings, dents, repairs or bleeding. Silver plate has minimal wear.
Please see our inventory for more British and American sterling and plate silver as well as antiques of all kinds.
Assets Antiques
- Sarasota, Florida
- View Storefront
- View Store Policies
Payments Accepted:
Negotiated with SellerItem Details:
- Reference #
- 2644pot
- Category
- Metals
- Department
- Antiques
- Type / Pattern
- Silver plate
- Year
- See Description
- Dimensions
- Width: 9 inches
- Height: 7 inches
- Depth: 0 inch
- Weight: 5 pounds
- Condition
- See Description
- Style
- Victorian


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18-Year-Old Smokes Pot, Makes News, Tweets Nice/Unnecessary Apology
About 7.2 percent of 8th graders, 17.6 percent of 10th graders and 22.6 percent of 12th graders had used marijuana in the month before a 2011 National Institute on Drug Abuse survey on pot use. And that's just the percentage of kids who feel comfortable enough to admit it to the feds.
Of course he is — brah's been going to Phish shows.
TMZ, as usual, went heavy on the judgment-laced puns and unrelated stories about it, even though the world's most famous castration target is 18 years old and what seems to be as grounded a teenager as possible considering he's rich as hell and his most mundane tweets rack up 40,000 RTs.
• The Connection: Bieber/Phish Lovefest Continues at MSG
• Pornhub Has Just the Thing to Help Bieber Get Over Selena Gomez
Bieber felt compelled to apologize to all his Beliebers out there on Twitter following the report, which broke on Saturday.
Sure, he's a God to tweens everywhere. But Bieber is an 18-year-old overgrown child who needs normalcy more than anything else in his life. He needs to kick back with his buddies and do what relaxes him. If that's a relatively harmless drug that's never directly killed anyone ever, so be it.
Bieber's apology is noted, and it's comforting for the parents of his impressionable fans to read that, but he is not Johnny Dakota, and this is not Saved By the Bell — his apology was totally unnecessary.
• Live Out Your Wildest Fan Fiction Fantasies With a Bieber Blow-up Doll
• About That Thwarted Plot to Kill and Castrate Justin Bieber …


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Progressive rock powerhouse Styx has been named the first band in history to release four consecutive triple-platinum albums. With distinct arrangements, pitch-perfect harmonies and an explosion of rock theatrics, Styx performs their popular singles such as "Blue Collar Man", "Come Sail Away", "Crystal Ball", "Renegade" and the big finish - everyones favourite from the Grand Illuion album.
More Information - http://www.fallsviewcasinoresort.com/entertainment/event/styx
Fallsview Casino
6380 Fallsview Boulevard
Niagara Falls


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Daily Update November 30, 2010
30th November 2010 23:59 | #1 |
Site Administrator
New Chapters for today: Franken Fran Chapter 45 Higurashi no Naku Koro ni Kai - Meakashi Chapter 13 Ikigami Chapter 36 Initial D Chapters 576-577 Mahou Sensei Negima! Chapter 310 MiXiM Chapter 121 Noblesse Chapter 161 The World God Only Knows Chapter 123 Violinist of Hameln - Shchelkunchik Chapter 35 Andy Kerr Mangable guy Click here for community rules *You can now change your email address. Click here |
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text:
By Eric Savitz
Apparently relieved that results weren't even worse, investors are bidding up Nokia (NOK) shares this morning despite third quarter results that were slightly worse than expectations.
The company posted sales for the quarter of 12.2 billion Euros, down 5% year over year and off 7% sequentially. Profits of 29 Euro cents a share were about two cents short of expectations. Nokia sold 117.8 million mobile devices in the quarter, up 5% year over year and down 3% sequentially. The company says industry units were up 8% year over year and 2% sequentially, which implies lost market share.
Still, the mobile phone giant said it expects industry device volumes to be up sequentially in Q4, with the company maintaining or gaining share. The company sees 2008 industry units at 1.26 billion, up 10.5% from 1.14 billion in 2007. Nokia says the mobile infrastructure and fixed infrastructure markets should be flat this year in Euro terms versus 2007.
Nokia this morning is up $1.29, or 8.5%, to $16.40.


text:
This Classified is Closed
For Sale:
PRICE DROP Paul Smith 'The Westbourne' 100% Wool Blazer Made in Italy 40R
Will Ship To: Anywhere
A luxurious Paul Smith 'The Westbourne' 100% Wool Blazer. Inspired by classic English tailoring but with a modern slim silhouette:
- Made in Italy
- 100% wool
- 3 button
- Notch lapel
- Measurement: chest (pit-to-pit) 19 1/2", sleeves 25 1/2", shoulders 17 1/2", length (top of collar to bottom) 32"
- Two outside front flap pockets, one outside ticket pocket, three inside pockets, one inside pen pocket
- Double vent
- Fully lined in purple fabric with multi strip trim
In excellent condition with no missing buttons, rips, tears or stains. Price includes shipping in CONUS. International buyers contact me for a shipping quote.
Edited by seoulman72 - 10/8/12 at 7:29pm


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Another great collections of deaths and burials that has now been added to the Historical Collections at www.familysearch.org are those from India. Over 566,000 records for the 1719-1948 time period have been added. The collection is name search able and can be found at the following link; India Deaths and Burials, 1719-1948.
The image above, the death of Simon Cohen is a good example of the information that is provided. As always the collection can be searched for free from the comfort of your own home.


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Building on a tradition of excellence, FRIENDS AWARE offers social, occupational, and residential opportunities in a caring atmosphere to individuals with developmental disabilities.
To be an agency where ALL individuals are challenged to realize their full potential.
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I won a contest to attend a cooking school in Portugal, where the chef laughed at all ideas of cooking light. This is my version of one his recipe, where I cut back on the olive oil and heavy cream. It reminds me of the flavors of Miguel's roast, but I don't feel guilty about eating it.—Jessie Grearson-Sapat, Falmouth, Maine
- 2 large potatoes, peeled and cut into 1-inch cubes
- 3 tablespoons olive oil, divided
- 3/4 teaspoon pepper, divided
- 1/2 teaspoon salt, divided
- 2 cups dry red wine or chicken broth
- 1/4 cup tawny port wine or grape juice
- 1 cup pitted dried plums
- 2 fresh rosemary sprigs
- 2 pounds pork tenderloin, cut into 1-inch cubes
- 1 cup reduced-sodium chicken broth
- 2 tablespoons reduced-fat cream cheese
- 2 tablespoons heavy whipping cream
- Additional fresh rosemary sprigs, optional
- Place potatoes in a large bowl; drizzle with 1 tablespoon oil. Sprinkle with 1/2 teaspoon pepper and 1/4 teaspoon salt; toss to coat.
- Transfer to a greased 15-in. x 10-in. x 1-in. baking pan. Bake at 400° for 40-45 minutes or until tender, stirring occasionally.
- Meanwhile, in a small saucepan, combine the red wine, port wine, plums and rosemary. Bring to a boil; cook until liquid is reduced to about 1 cup, about 25-30 minutes. Remove rosemary and discard. Transfer to a blender; cover and process until smooth. Set aside.
- Sprinkle pork with remaining pepper and salt. In a large skillet, brown pork in remaining oil; remove and keep warm.
- Add the broth, cream cheese, cream and plum mixture to skillet; cook over medium-low heat until blended. Return pork to the pan; cook and stir for 8-10 minutes or until meat is no longer pink. Serve pork and sauce with potatoes. Garnish with additional rosemary if desired. Yield: 4 servings.
Originally published as Portuguese Pork Tenderloin in Taste of Home Christmas Annual
Annual 2012, p42
Light-Bodied Red Wine
Enjoy this recipe with a light-bodied red wine such as Pinot Noir.
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ISP Question
I'm trying to upgrade my ISP at home. In protest of a monopoly who charges $50 a month, I refuse to get Mediaone until there is competition. I'm looking for a better ISP for 56k. A quick search of the list finds these in my area code:
A+Net M3Net InREach Juno Tiac IBS Mpower Spire Question: Anyone have any preferences or opinions on any of these. We basically want the 56K to be functional most of the time , ESPECIALY during peak times (e.g. 7-9 pm). Thanks, Terry |
RE:ISP Question
Terry -
I use free ISP services (Netzero, etc) and tolerate the advertising. Why can't they give me flyfishing ads so I would pay attention? http://22.214.171.124/images/flytalk/Wilk.gif I'll be listening to the replies you get; I am also looking for a good service. Unfortunately there are very few options where I live. I assume you are not going for broadband due to the high price... but don't some also eliminate the extra phone line charge? |
RE:ISP Question
Yes the extra phone line is $15-20 per mo. A good ISP is about the same. So $30 to $40 a month. But I was gonna hold off on the extra line and just turn on the cell phone. There is some overlap there in service. Why have an extra phone line while your cell sits quiet? That's if you can tolerate giving your cell # as an alternative.
As for the $$$ aspect we're looking at building an addition to the house and until I'm comfy squeezing into the big increase in monthly payments I'm leary of taking on a Mediaone rate of $50/mo. ($600 per year) . And since they are a monopoly they can go to $59.00/mo. anytime they want. I don't like it. So a solid 56K should do. And it helps to have other means available to download larger files to zip disks, like work for some people. I mean how often do you need to download a 16MB Netscape upgrade? Terry |
RE:ISP Question
Try gis.net, I used their dialups before I went to their dsl and they were great on dialups!
RE:ISP Question
I use concentric as my dial-up ISP and they have a flat rate $ 19.95/mo for unlimeted access. No 800 dial-up access at this rate but lot's of local numbers.. |
RE:ISP Question
First Mediaone is not $50 a month it's $49.95. [img]http://126.96.36.199/images/flytalk/Happy.gif" border="0" align="middle">The service is really $39.95 per month and $10.00 rental of the cable modem. You could buy your own modem for about $200.00 and it will pay for itself over time. I've had it for 2 years and the price hasn't gone up. Probably because DSL is starting to catch up. There are inherent advantages and risks to being online 24/7/365. Email me for details. Or you can go to Kmart and pickup a Bluelight CD for free dialup access. <img src="http://184.108.40.206/images/flytalk/Wilk.gif[/img] |
RE:ISP Question
Just saw a AT&T global access commercial, 4.95 unlimited / month. Might be a good way to go!
I tried Blue light (free), big ad strip across the screen and s-l-o-w in my area. NetZero is a good free alternative, pretty snappy connections for me as well. |
RE:ISP Question
FWIW, before I got a cable modem ($29.99/mo if you have cable TV, +$10 if not) I have Earthlink for $19.95/mo and it only let me down about 5 times in a year (probably due to maintainence since it was 1-3am).
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Used MG cars for sale in Stockbridge
We currently have 0 used MG cars available in Stockbridge. With the widest range of private and trade MG cars available in Stockbridge, you have access to the biggest choice and the best prices.
Feel free to browse our selected vehicles, further refine your search, and find your perfect car.
Latest second hand MG cars for sale in Stockbridge
Sorry, it looks like we have no used MG cars available in Stockbridge
However we currently have:
12 Used MG cars available in Hampshire on Auto Trader
Selection of the latest second hand MG cars for sale in Hampshire
Showing 1 - 10 results | Attributes | Price | |
MG ZS 1.8 120 5dr
2006 (06 reg) Hatchback
VERY LOW MILEAGE......1 OWNER FROM NEW......1 VEARS MOT....., Next MOT due 27/03/2018, Alloy Wheels (16in), Airbags, Body Coloured Bumpers, Electric door mirrors, Remote central …
£2,165 | |
MG TF 1.8 LE 500 2dr
2009 (59 reg) Convertible
Fantastic MG convertible in the classic British racing green. Incredible low miles for year and in superb condition, owned by a local gentleman who always kept the MG garaged., Full …
£6,995 | |
MG TF 1.6 2dr
2004 (04 reg) Convertible
low mileage with service history, drives superb, has all the hood cover and recent new rear plastic window, excellent value, Black Cloth interior, Alarm, Alloy Wheels (15in), Electric …
£1,995 | |
MG MGF 1.8 VVC 2dr
2001 (51 reg) Convertible
Rover in the log book and one fastidious owner who kept it in heated garage, unmarked body the hood does not even look like it has been folded! full history from one of the last …
£3,750 | |
MG TF 1.8 135 2dr
2005 (05 reg) Convertible
Full 12 months mot, march 2018, just had new rear discs and pads for mot, last owner 9 years, remote locking, Electric windows, hard top included, soft top in very nice condition, 4 …
£1,795 | |
MG MG6 S GT Dti 5dr 1.9
2015 (15 reg) Hatchback
1 owner, Grey, MG 6 S GT Dti 5drUnbelievable MG, nearly new. Great looking car, cheap tax, cheap insurance, 150bhp, 6 speed, diesel, one owner.Finance available. Please ring for …
£6,995 | |
MG MG3 1.5 VTi-TECH 3Style Lux 5dr
2015 (65 reg) Hatchback
RIDGEWAY SELECT is part of the MARSHALL MOTOR GROUP LTD, one of the UKs Leading Dealer Groups. Our Used Cars are carefully selected Part Exchanges from our Main Dealerships.., …
£7,000 | |
MG TF 1.8 135 2dr
2009 (59 reg) Convertible
Excellent condition MG TF. Low mileage 22313. Mileage at last full service on the 11/6/2016 was 20772. Price includes the hardtop which is currently fitted to the car but happy to …
£5,700 | |
MG MG3 1.5 VTi-Tech 3Style 5dr
2014 (14 reg) Hatchback
Superb Condition Inside and Out, Fully Serviced and MOT'd if Required, Excellent Finance Options Available, ASK ABOUT PCP, Viewing and Test Drive Highly Recommended. If you …
£5,995 | |
MG ZR 160 3dr 1.8
2004 (04 reg) Hatchback
5+ owners, Grey, MG ZR 160 3dr Nice clean car, MOT September 2017, drives well, £995
£995 |


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(Before I start getting mail about Opera or Netscape or other browsers, let me first say that I am concentrating on Firefox because it is what I use and because it is the most widely used alternative browser for Windows systems. Doubtless the other alternatives have their virtues but Firefox is free and is probably the easiest for Internet Explorer users to adapt to. PC Magazine has a recent review of several browsers.)
Why consider another browser?
By technology standards, Internet Explorer (IE) is an old design. Except for some changes added in Windows XP SP2, Microsoft apparently has no interest in upgrading IE until the next Windows operating system called Longhorn (now Vista) comes out. Meanwhile, everyone with older versions of Windows will see no improvements. In fact, it seems possible that only those with Windows XP SP2 will receive all the security patches.
Note added after this article first appeared: On February 15, 2005, Bill Gates announced the reversal of the previously stated Microsoft policy that no new version of Internet Explorer would be available separate from the next Windows operating system called Longhorn. Instead, Gates said that a beta version of Internet Explorer version 7 would be released sometime in the summer of 2005. However, it would be available only to owners of Windows XP, version SP2, meaning that those with older versions of Windows are still out in the cold.
Second note added October, 2006: Internet Explorer 7 has now been released for Windows XP SP2. It contains increased security features including anti-phishing measures. Windows Vista (formerly Longhorn) is in final beta and will appear shortly. Its version of IE 7 will have the added security feature of being able to run with reduced privileges. Firefox 2 is also in its final beta before release and also contains anti-phishing defenses.
Newer browsers like Firefox have added features and continue to be updated and improved. These new features will appeal to many and will be sufficient to attract them to use a different browser. However, whether someone prefers this or that browser depends to a considerable extent on the level of the user's computer sophistication and on individual patterns of Internet use. Since these pages are aimed at the typical home PC user and Internet security issues, I am not going to dwell on tabbed browsing or the features like the built-in popup blocker or the various extensions that Firefox has. Those who wish more details can check out these aspects of Firefox in the references in the sidebar. For example, Scot Finnie has an extensive review.
For the average home user the big issues in choosing a browser are convenience and security. IE can probably claim an edge in convenience because it's already there and the Microsoft desktop monopoly means that many Web sites are optimized around the way IE behaves (even though IE does not follow the World Wide Web Consortium standards). From inertia, many home PC users will be prone to stand pat with the IE that they already know and use. However, IE falls down in many ways when it comes to the all-important issue of security. In the September 16, 2004 issue of the Wall Street Journal, Walter Mossberg, the respected writer on consumer technology, described the Internet security problem this way:
If you use a Windows personal computer to access the Internet, your personal files, your privacy and your security are all in jeopardy. An international criminal class of virus writers, hackers, digital vandals and sleazy businesspeople wakes up every day planning to attack your PC.
Along with other suggestions for protecting your computer, Mossberg went on to recommend changing to the Firefox browser. As can be read in the references in the sidebar, Mossberg is only one of many commentators who have recommended dumping Internet Explorer and changing to Firefox or other browser for security reasons.
One of the reasons IE is particularly vulnerable is its use of the Microsoft technology called ActiveX, which is discussed on another page. ActiveX is a convenient programming tool but it is exactly this convenience that is its undoing. It allows unscrupulous types easy access to the Windows operating system either by subterfuge or programming tricks that fool unwary surfers. Windows XP Service Pack 2 tightens up the security but problems remain and older Windows systems are left out of any of the SP2 security improvements. As is discussed in detail on other pages, the ActiveX settings for the various security zones of IE can be configured for greater security by experienced PC users. However, the average PC user may find the procedure a little daunting. Also, disabling or configuring the ActiveX settings lessens one of the advantages in convenience that IE has.
Another source of trouble is that IE itself is deliberately designed to be closely tied into the operating system. This integration means that problems in IE can affect the whole system. Many of the seemingly endless parade of Windows security holes are related to problems with IE. Even since the SP2 upgrade of Windows XP, more IE problems have been uncovered.
Note that other browsers such as Firefox do not support ActiveX. Also, they are separate software applications.They do not have intimate access to the Windows operating system. This makes for less versatility but is a lot more secure. Firefox is clearly a safer browser to use than IE. But, as is usually the case, greater safety brings some loss of functionality. In the next section we look at the tradeoffs incurred in using non-IE browsers.
Drawbacks to using non-IE browsers
Some scripts may not work except in IE. Microsoft has its own version of JavaScript, different from the version used by almost everybody else. Well-designed sites provide for both versions of JavaScript but not all sites are so thorough. Also Microsoft has a proprietary script language called VBScript that only IE supports.
Microsoft also wants to be different when it comes to style sheet support and DHTML. They do not abide by the standards set up by the World Wide Web Consortium. All major browsers except IE conform to these standards. However, because IE is so widely used, some Web site designers tailor their sites specifically for IE and these sites do not resolve properly in other browsers. Also, IE is more tolerant of sloppy HTML that will not work in other browsers. I have not personally found this to be much of a problem in the sites that I visit but there are probably a lot of sites with coding errors that only IE will forgive. Note added later: IE 7 conforms better (but not completely) to W3C standards.
Strategy for more secure browsing
Experienced computer users who are well-versed in the many precautions that need to be taken on the Internet can make a choice of browser based on its features and their personal preferences but I am concerned with the less knowledgeable home user.
Typical home PC users should give very serious attention to the possibility of using an alternative browser and overcome their natural reluctance to get involved with reconfiguring their computer in any significant way. Unfortunately, the security problems on the Internet have reached the point where everyone should think about whether to continue using IE as their browser. This is especially important for anyone continuing to use Windows operating systems older than XP. Older systems will get no more IE upgrades from Microsoft. Firefox is an attractive and safer alternative with many positive features. Its interface is similar to IE and it has functions to import IE favorites and cookies so that it is no problem to begin using it right away. Click here to download (4.7 MB). Detailed instructions on how to install and use Firefox are given in references in the sidebar including a step-by-step guide (IE users will need to scroll down at this site). For additional help go here.
IE will still have to be used for some sites for reasons given in the preceding section. It is important to configure the Internet zone in IE to high security (see these pages for instructions) and to disable ActiveX and scripting in this zone. Those sites that will require IE and are known to be safe should be put in the Trusted zone (instructions here) where AciveX and scripting will remain enabled.
Those who prefer to continue to use IE as their main browser should harden the defenses by following the procedures given in these pages. Note that these more stringent security settings for IE will mean that ActiveX and scripting will be disabled except for sites in the Trusted zone. Anyone using AOL is actually using IE under the AOL interface and should take measures accordingly.


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". . . for in this queer world of ours, fatherly and motherly hearts often beat warm and wise in the breasts of bachelor uncles and maiden aunts. . ."--Louisa May Alcott, Eight Cousins
Recipe Time
So I got to clean 3" of snow off my car and make my way, carefully, home by 10 p.m. I'd say we probably got about 5" or so of snow total. I cleaned more off the car this afternoon. The sun's out, but it's cold.
I wanted to share this pancake recipe I made last Saturday to use up expiring orange juice and soymilk, and a leftover packet of dried cranberries from a bag o' salad, but I couldn't find a link for it. So here is my recipe, adapted from Prevention's Feb 2008 issue, for Cranberry-Orange Oat Pancakes:
1/2 c old-fashioned rolled oats
1/2 c whole wheat flour
1/8 c all-purpose flour
1-1/2 T packed brown sugar (I probably used less, because I don't like things too sweet)
2 t baking powder
1/2 t ground cinnamon (I used Cinnamon Plus)
dash of salt
1 large egg
1/2 c orange juice
1/4 c. milk or milk substitute (I used plain soymilk)
1/4 c canola oil (they said you also could use extra virgin olive oil but that seems weird to me)
about 1/4 c sweetened dried cranberries (I didn't have quite that much, so I threw in a pinch of chocolate chips! Nuts might also be a nice addition.)
Time: about 20-30 min.
Servings: 4 (eight 4" pancakes)
1. Preheat nonstick pan or griddle (if you're lucky enough to have an electric one, heat it to 325-350*F)
2. Whisk together oats, flours, sugar, baking powder, cinnamon, and salt in large bowl.
3. In medium bowl, whisk together egg, O.J., milk and oil. Add wet ingredients to dry ingredients and stir just enough to combine.
4. Fold in cranberries (chips, nuts, etc.).
5. Drop just under 1/4 cup of batter onto griddle and cook until edges look dry and bubbles come to the surface (about 3-4 min.). Flip and cook until bottom browns and pancake is cooked through (about 1-2 min.). Repeat until all batter is used up.
I had a little maple syrup with mine. They are very filling, so I'd say eat about two or three and then freeze the rest. They nuke well.
2 comments:
- Amy Giglio said...
sounds yum . I use EVOO a lot in baking because its fruity flavor lends itself well to sweets and it's better for you than Vegetable oil. I've used safflower oil in baking too, but it doesn't turn out as well. The cakes just sort of fall apart. EVOO has health benefits without sacrificing structural integrity of the cake.
Did I just write that? Dang, I'm almost incoherent. I must go to bed. Feel free to delete this, Kate. - 2/4/09, 11:25 PM
- Kate P said...
You were up watching "Top Chef," weren't you? :)
I think when my sister and I made brownies for her party in December, she used olive oil. I guess I will have to try it when I make the pancakes again! - 2/5/09, 11:44 PM


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Won't those be too bright? :P Generally speaking a darker IEM will suite the Hisound products very well. The FX700s & Studio V was a marriage made in hell. Way too much detail & too bright. The detail forced itself on you. So instead of listening for that detail it was just attacking you lol ;).
Edited by lee730 - 11/26/12 at 12:46am


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By DAMON LAWRENCE
Area lawmen testified in an investigative Tuesday afternoon that Roane County Constable Mark Patton told them he will damage the reputations of several area officials if assault charges against him are not dropped.
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By PR Newswire | Article Rating: |
December 12, 2012 10:57 AM EST | Reads: |
106 |
LONDON, December 12, 2012 /PRNewswire/ --
Integer Research has confirmed that over 100 public sector fleets have registered for their Diesel Exhaust Fluid (DEF) price tracking index, DEF Tracker, following a nationwide campaign.
Public sector subscribers include government, state and municipal fleets. DEF Tracker has welcomed subscribers from a number of U.S. states, including New York, Florida, Texas and California, and Québec and Ontario, in Canada.
This is welcomed news for the DEF industry, as distributors push for a move away from long-term guaranteed contract prices and the use of urea price indexes, towards a more market related structure which takes into account fluctuating freight and supply costs.
"DEF Tracker provides independent and accurate monthly price references for DEF in the fleets' specific geographies, reflecting real market transactions and the real costs involved in the supply chain", said Monica Baker, Emissions Research Manager at Integer Research: "It is fantastic to see interest from public fleets so early on in this campaign. We believe that this service will play an important role in encouraging price transparency within the market".
Doug Haugh, President, Mansfield Oil Company, a national DEF supplier, said: "It is important, as volumes increase, that we do not rely on a NOLA [New Orleans, LA] urea index that does not represent the costs involved in the DEF business and therefore leaves both buyers and sellers exposed to unnecessary risk".
Purchasing professionals can use the service as a reference to better understand how the market is evolving in their area.
A complimentary sample of the service can be requested by emailing firstname.lastname@example.com, and quoting 'Sample Tracker NW' in the subject line.
About DEF Tracker
DEF Tracker publishes monthly market pricing for full truck loads and less than truck load bulk deliveries, tote refills and 2.5G jugs for a wide range of pricing hubs, as well as DEF pump prices in every U.S. state and Canadian province offering the facility, backed by solid analysis from industry experts.
A complimentary sample of the service can be requested by emailing email@example.com, and quoting 'Sample Tracker NW' in the subject line.
About Integer Research
Integer Research is a specialist provider of research, analysis, consultancy and conference services for global emissions control markets.
It stands as the largest DEF research group in North America, and has been tracking this market since its start in 2010.
Contact: Tomas Benjamin, +44(0)20-7503-1265
SOURCE Integer Research
Published December 12, 2012 Reads 106
Copyright © 2012 SYS-CON Media, Inc. — All Rights Reserved.
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Ya. I know. Small potatoes, but a milestone nonetheless. :)
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CREATION DAYS - Learn the order of events during the Creation week.
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Workers Comp Matters
August 25, 2005Share this Episode
Medicare Set-Aside Allocations
WORKERS COMP MATTERS, hosted by Attorney Alan S. Pierce focuses on the issues relating to people who have been hurt at work. On this show, we discuss medicare set-aside allocations in workers comp cases and what you need to know for your clients on this complex issue. Special guest for the show is Jean Feldman, Senior Vice President of Care Management Operations for CHOICE Medical Management in Tampa and author of 'Navigating the Murky Waters of Medicare Set-Asides' in the Journal of Workers Compensation. And don't forget to guess the outcome of the "Case of the Day' at the end of the show!


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I have it: 52 I had it: 32 I want it: 34
Designers » T-Z » Victoria`s Secret Floral Fruity « Groups
I have it: 52 I had it: 32 I want it: 34
Pretty in Pink is a delicate mixture of melon, lily of the valley and raspberry. It belongs to the Secret Garden collection.
It is available as EDT, body mist and body care collection.
Perfume rating: 3.26 out of 5 with 61 votes.
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Received this as a gift and hated it. I didn't feel any of the notes were visible in this scent. It smelled like cheap dollar store soap, which I hate saying because I feel like that's everyone's general comment, but I really can't compare it to anything else. Too synthetic, stung my nose, and gave me a headache.
Sweet and fresh, a good one for a date or even just to smell good around the house. Candy like, I don't get any bubble gum though. A lot of melon, it surprises me that it's not on the label, I do get raspberry, but in the background really, the melon is a lot stronger. Reacts really well with my body chemistry, and has longer staying power than a lot of VC scents. I love to layer this, the shower cream smells amazing and actually leaves my skin really soft, the lotion and the body spray all smell the same (a common problem I've found with sets is that one smells stronger or slightly different/better). I don't smell any floral, but I suppose there is some for balance.
This is a happy fragrance I wish they still had at Victoria's Secret. It reminds me of happy times in the summertime back when it first came out. You can smell the melon & strawberries in it! There's nothing else like it & it gets me in a great mood when wearing it! It's very romantic and feminine.
Just found this at the VS Semi-Annual Sale, and the bottle says the notes are raspberry and peony?? I think the original notes sound more accurate because I definitely get the melon in the fragrance, and the raspberry is kind of sugared. I don't get any lily whatsoever. Overall the fragrance is pretty sweet, but it isn't too bad. It definitely has that vibe that most (if not all) of the classic secret garden scents have - you can tell it comes from VS. I like it, though! Good for lazing around the house or grocery shopping, that sort of thing. I am satisfied with my purchase :)
do they have it in vs stores right now?
I just picked this up in body spray, and the packaging doesn't even mention the melon. It says its raspberry and peony, which are two of my favorite notes. Well, I'm getting neither of those notes. I am getting more melon than anything else, which is a disappointment. I do get a bit of a raspberry accord in the drydown but, this being a body spray, its so faint, I can barely smell it. I don't find this overly sweet or floral, but there is a murky muddy quality to it that I am finding in some other VS scents as well. Not my favorite for now, but I'll give it a chance and see if it grows on me.
They just re-released this one so see if your VS store has it! I really like this one, if the color pink had a smell, this is what it would be. Sweet and sugary and slighty fruity. I wish it came back in an EDT because body mists don't last long on me. But I do like the lotion :)
Smells like melon bubblegum! I wanted this scent for so long and finally found it on ebay but now it's collecting dust because I never wear it. I'll probably end up selling it because I don't like this at all.
I wore this years ago, when my ex-husband bought it for me. I didn't like it at all at first, but it really grew on me. It's amazing how relative fragrance is - I'm not getting much fruit at all. I get a smoky, lightly sweet, somewhat generic floral. Wet ashes of roses. But I love it, and felt impelled to buy another bottle.
I found this to be very youthful and for girls in there 20's.
This was discontinued a few years back and reappearing
In victoria secret stores at annual sales for awhile, I wore this
in my twenties also. Found it on E-bay. Purchased it and wear
In the summer. This is a refreshing Happy smell with staying power
when layered yummy. Loved it.
Pretty in Pink is like watermelon flavoured chewing gum in a bottle to start with. Really 'fresh' but the fresh is quite headach-inducing, just like many Victoria's Secret fragrances, kinda nice/chewing gum/edible smelling, but if I smelt more than 2 sceonds of it, I'll have a instant headach as if there's something weird in the ingredients.
Then the scent gets tamed a little bit, which smells like tart sweet fruit jam mixed with weird Play-doh smell in the background. Maybe this is a good example of non-harmonic blend of lily-of-the-valley and raspberry.
Then it goes quite linear from there, and less and less Play-Doh smelling.
I don't find Pretty in Pink anything near pretty or pink, instead, it makes me think of a weird drama of watermelon chewing gum, synthetic plastic fake flower for decoration in the 80s and a jar of jam left in the sun for too long.
I love this scent and I thought it was discontinued and I couldn't find it anymore!
One word: bubblegum! And even a gourmand fan like me, who doesn't mind walking around with the risk of being eaten, finds bubblegum to be cheap.
I got so disappointed when I got this(and it's not easy to get a hold of Victoria's Secret products here!)
Bubblegum fragrances, just like that Paris Hilton one, turns into a weird green note on me. Almost like mold! Eww.
I bought the whole set of Pretty in Pink, wish I picked something else. I let my brother gift this to his girlfriend. The body lotion and mist are more tolerable.
red raspberry jam
ooey gooey concoction
trailing warm melon
I love this perfume its fragrance is very sweet and fruity very mesmerizing! surely get compliments.
It smells so sweet and lovely of melon. LOOOOve this.
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Thank you for talkin about what the 4k honor compensation was about. i had no idea, and thought I was getting free honor for nothing. Well...not now, but its okay.
"if you bought a piece of season 9 gear before it became season 10 ilevel, you will be receiving 4000 honor as compensation."It has not yet been confirmed what qualifies you for the 4k honor, please don't post missleading info.
The most 'fair' thing for Blizzard to do would be to track down everyone who bought a piece of Season 9 gear before it became Season 10, and upgrade it to Season 10, realistically, seeing as that was the original intent behind the honor point / new gear system.
You can get kill credit for molten lords tapped by other players as long as you do damage to it. This was to fix an issue when they were getting tapped buy Dressierter Feuerfalke while doing the quest Feuer am Himmel.
It looks like I'll be making a profit. I already had all of last season's gear through CP, but decided during the Season 9 Honour Week to buy a single cloak for 1250 points, as a sidegrade for my new spec. Some free Season 10 gear incoming.
You would probably have a higher chance of Blizzard seeing this if you posted on the official site.


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it seems consistant (atleast in the uk) that the on disk version is cheaper by at least £10 compared to steams 39.99 price point. has it been made known that the disk version activates on steam ? im on the fence for this game and making it a little cheaper may push me over.
also does anyone know why it is cheaper ? i would have thought that a disk version would have extra costs associated with production than in digital which is just generating a license


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Medication and Surgery
Both drugs and surgery are used to treat chronic IH. Medical (or Drug) therapy is generally tried first, but if there is an immediate risk to vision, chronic pain that cannot be relieved or a poor response to drug therapy, then surgery is performed. It is not unusual for people with chronic IH to undergo both drug therapy and surgery in an effort to control their intracranial pressure.
Drug Therapy
Carbonic Anhydrase Inhibitors
Carbonic anhydrase is a crucial enzyme needed in the production of cerebrospinal fluid. When this enzyme is suppressed, production of CSF decreases, which also lowers intracranial pressure.
The most common carbonic anhydrase inhibitor and the main drug used to treat chronic IH is acetazolamide (Diamox). Methazolamide (Neptazane), a similar drug from the same family as acetazolamide, can also be prescribed. Other drugs with carbonic anhydrase inhibiting properties include furosemide (Lasix) and topiramate (Topamax).
Acetazolamide was originally developed to treat glaucoma by reducing the production of aqueous fluid within the eye, which lowers intraocular pressure. Acetazolamide is a sulfonamide but its molecular structure differs from sulfa drugs, which means that certain people who are allergic to sulfa antibiotics may still be able to take acetazolamide. However, any treatment should first be discussed with and supervised by your physician.
Daily dosages of acetazolamide can range from 1-4 grams depending on the individual. In addition, potassium supplements may be necessary since most carbonic anhydrase inhibitors are diuretics, as well. Many people notice tingling in their face, hands and feet; a metallic taste when drinking carbonated beverages; fatigue; and a lack of appetite when they first begin taking acetazolamide. These initial side-effects tend to dissipate over time.
If drug therapy is successful, surgery can sometimes be avoided. However, carbonic anhydrase inhibitors have several drawbacks. The drugs block other similar enzyme systems elsewhere in the body (i.e. the eyes and the kidneys), with unknown effects. Some who take acetazolamide may develop kidney stones; the drug also carries a very rare risk of aplastic anemia, a serious blood disorder.
Carbonic anhydrase inhibitors can be difficult to tolerate long-term and for some people, the drugs are just not effective. But since no drug has been specifically developed to treat chronic IH, they are currently the only option.
Other Drugs
Treatment of pain, especially headache pain, can be challenging. In addition to using carbonic anhydrase inhibitors, some physicians try to treat the headache that accompanies chronic IH. Medications for chronic headache like tricyclic anti-depressants, beta-blockers and calcium-channel blockers may be used, depending on the individual.
The long-term use of corticosteroids to treat chronic IH has fallen out of favor, unless there is a secondary inflammatory process caused by an underlying disease like lupus or Behcet disease. While corticosteroids may lower intracranial pressure in the short-term, the drawbacks to steroids include weight gain, fluid retention and a rebound in intracranial pressure during the drug's withdrawal.
Prescription pain medication may also be a part of drug therapy. While most pain medications have little effect on headaches caused by intracranial hypertension, they may temporarily affect the intensity of a headache for some people.
It's not uncommon, especially among those who are undiagnosed, to turn to over-the-counter headache medications in search of relief. But excessive use of these drugs can lead to rebound headaches, as well as other conditions, like thinning of the blood. While the relationship between headache pain and IH is not fully understood, lowering intracranial pressure remains key to reducing chronic IH pain.
In 2007, researchers at Athens General Hospital in Greece published the results of a clinical study in which 26 patients with idiopathic intracranial hypertension (IIH) were treated with octreotide, a synthetic hormone that is sometimes used in the treatment of tumors and in certain endocrine disorders. The results were very positive but octreotide as a possible therapy for IIH needs to be evaluated in a controlled, double-blind study, something both the study's researchers and IHRF advocate.
To read more: http://www.ihrfoundation.org/hypertension/info/C172
Optic Nerve Fenestration
When sight is at risk and drug therapy has been unsuccessful, an optic nerve fenestration (also called an optic nerve sheath decompression) is usually performed. The operation can be done on one optic nerve sheath (unilateral) or on both optic nerve sheaths (bilateral).
During surgery, a small window-like opening is made in the sheath around the optic nerve, which allows cerebrospinal fluid (CSF) to drain behind the eye and relieves optic nerve swelling. This surgery is done primarily to save vision, rather than to alleviate headaches.
Neurosurgical Shunts
Shunt operations are also performed when drug therapy has been unsuccessful. Shunts may be used to control papilledema and prevent vision loss, as well as to treat headaches that have been unresponsive to any medication. A neurosurgical shunt is a surgically-implanted catheter that is used to drain CSF into another area of the body such as the abdomen. A shunt lowers intracranial pressure by removing CSF to another site, where it can be absorbed.
Most Common Types of Shunts
Lumboperitoneal shunt (LP shunt)
An LP shunt diverts CSF from the lumbar sub-arachnoid space (spine) to the peritoneum (abdominal cavity).
Ventriculoperitoneal shunt (VP shunt)
A VP shunt diverts CSF from a ventricle in the brain to the peritoneum (abdominal cavity).
Cisterna magnum shunt
A cisterna magnum shunt diverts CSF from the cervical cistern (back of the head) to the peritoneum (abdominal cavity). These types of shunts are generally used when it is not possible to use an LP or VP shunt.
Other areas of the body into which CSF can be drained include the pleural cavity (chest), and the atrium (heart).
Many shunts used today have programmable valves, which means that the valves are externally adjustable. The advantage of a programmable valve is that after surgery, a physician can adjust the valve's rate of drainage non-invasively, with the use of a magnetized device. Shunts with programmable valves can be affected by magnets used to produce MRIs, and may need to be adjusted after the imaging is completed.
Shunts have a checkered history with an initial 50% success rate and alternately, a high revision rate of 50%.The most common problem with shunts is that the catheter becomes blocked and has to be replaced. Shunts are the most common pediatric neurosurgical procedure and the second most common neurosurgical procedure for adults.
Cerebrospinal Stenting
Some people with IH who are either non-responsive to medication or are intolerant of it, and who have also been found to have a true narrowing (stenosis) of a major venous channel at the base of their brain, may be candidates for a surgical procedure known as stenting.
The stenosis is detected on imaging studies (CT or MR venography), which is then confirmed by actual direct pressure measurement within the narrowed vein (direct angiography). The presence of a true stenosis restricts blood flow through a large venous blood vessel, thereby raising blood pressure within the cerebral venous system. (This pressure is different than arterial blood pressure, which is measured by your doctor with an arm cuff)
As fresh CSF is continually produced within the brain, "used" CSF normally drains unidirectionally into the cerebral venous sinuses, after circulating in the subarachnoid space. If the venous blood pressure is abnormally high from a stenosis, then CSF pressure must correspondingly rise in order to flow into the venous sinus. This cause of intracranial hypertension can be relieved by surgically placing a stent (a small, tube-like device) in the stenotic area, which improves blood flow and lowers both venous blood pressure and the cerebrospinal fluid pressure.
While cerebral venous sinus stenosis is not a common finding for most people with IH, people who do have stenosis and undergo stenting often experience a significant improvement in the signs and symptoms of intracranial hypertension. Therefore, all patients with unexplained intracranial hypertension should undergo imaging (venography) to rule out the presence of a true stenosis.
There is no "perfect" treatment for chronic IH, especially since every person's experience is different. While surgery certainly helps some people, it can also lead to repeat operations, which can sometimes produce serious, even life-threatening complications. To make an informed decision, it is always best to discuss both the risks and benefits of any treatment with your physician.