text:
Study for Women With Platinum Resistant Ovarian Cancer Evaluating EC145 in Combination With Doxil® (PROCEED) (PROCEED)
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- How to Read a Study Record
Condition | Intervention | Phase |
Ovarian Cancer |
Drug: EC145 Drug: Pegylated Liposomal Doxorubicin (PLD/Doxil®/Caelyx®) Drug: placebo Drug: EC20 |
Phase 3 |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor) Primary Purpose: Treatment |
Official Title: | A Randomized Double-Blind Phase 3 Trial Comparing EC145 and Pegylated Liposomal Doxorubicin (PLD/Doxil®/Caelyx®) in Combination Versus PLD in Participants With Platinum-Resistant Ovarian Cancer |
- Progression-free survival based on investigator assessment using RECIST v1.1. [ Time Frame: up to 26 months ]Progression is assessed at 6 week intervals through Week 24 and at 8 week intervals thereafter.
- Compare overall survival of participants between treatment arms. [ Time Frame: Approximately 20 months after last patient randomized ]OS analysis will occur when 384 deaths have occurred.
- Incidence of Adverse Events, Serious Adverse Events, and Deaths. [ Time Frame: up to 26 months ]Adverse events (as a measure of safety and tolerability) will be assessed at each study visit.
Estimated Enrollment: | 640 |
Study Start Date: | April 2011 |
Estimated Study Completion Date: | October 2016 |
Primary Completion Date: | May 2015 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: Arm A
EC145 + Pegylated Liposomal Doxorubicin (PLD)
Drug: EC145
IV bolus on days 1,3,5 and 15,17,19 of a 4-week cycle
Drug: Pegylated Liposomal Doxorubicin (PLD/Doxil®/Caelyx®)
50 mg/m2 (calculated on the basis of ideal body weight) every 4 weeks. Dose reductions permitted for toxicity.
Other Names:
Drug: EC20
During the screening period participants will receive a single intravenous administration of EC20 prior to SPECT imaging
Active Comparator: Arm B
placebo + Pegylated Liposomal Doxorubicin (PLD)
Drug: Pegylated Liposomal Doxorubicin (PLD/Doxil®/Caelyx®)
50 mg/m2 (calculated on the basis of ideal body weight) every 4 weeks. Dose reductions permitted for toxicity.
Other Names:
Drug: placebo
IV bolus on days 1,3,5 and 15,17,19 of a 4-week cycle
Drug: EC20
During the screening period participants will receive a single intravenous administration of EC20 prior to SPECT imaging
Detailed Description:
This is a Phase 3 clinical trial to evaluate the efficacy and safety of the combination of EC145 and pegylated liposomal doxorubicin (PLD; available in the United States as Doxil® and outside the United States as Caelyx®) compared to PLD and placebo. Enrollment of 640 patients including approximately 500 that are folate receptor positive is planned.
EC145 is a drug that is specifically designed to enter cancer cells via the folate vitamin receptor (FR) that is not generally found on normal cells. Experimental evidence shows that this target receptor is expressed on virtually all ovarian cancers. Early clinical evidence in a small number of Phase I participants, in a subset of participants in a completed single-arm Phase II study, and interim data from an ongoing randomized Phase 2 study (PRECEDENT) suggests that EC145 may have antitumor effect in women with platinum-resistant ovarian cancer and that EC145 alone and in combination with PLD is generally well-tolerated. This evidence suggests that EC145 may be useful as chemotherapy against platinum-resistant ovarian cancer.
All participants will undergo imaging with the FR-targeting investigational diagnostic agent EC20 during the screening period to assess binding of the imaging agent EC20 to tumors. This non-invasive procedure will provide additional information on the utility of using EC20 imaging to identify subjects with the FR molecular "target" prior to treatment with EC145 therapy.
Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Participants must sign an approved informed consent form (ICF).
- Participants must be ≥ 18 years of age.
- Participants must have pathology-confirmed epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.
- Participants must have primary or secondary platinum-resistant ovarian cancer.
- Participants must have at least a single (RECIST v1.1-defined) measurable lesion.
- For the purpose of obtaining a RECIST v1.1 baseline scan, participants must have a radiological evaluation conducted no more than 28 days prior to beginning study therapy (PLD). NOTE: For participants with a history of CNS metastasis, baseline radiological imaging must include an evaluation of the head.
- Participants must have had prior debulking surgery.
- Participants must have received prior platinum-based chemotherapy for management of primary disease but must not have received more than 2 prior systemic cytotoxic regimens.
- Participants are allowed to have received, but are not required to have received, one additional non-cytotoxic antitumor agent (eg, biologic or cytostatic) for the management of ovarian cancer.
- Participants must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1.
- Participants must have recovered (to baseline/stabilization) from prior cytotoxic therapy-associated acute toxicities.
Participants must have adequate organ function including:
Bone Marrow Reserve:
- Absolute neutrophil count (ANC) ≥ 1.5x10^9/L prior to treatment. Participants on maintenance doses of granulocyte colony stimulating factor (G-CSF) are eligible.
- Platelets ≥ 100x10^9/L
- Hemoglobin ≥ 9 g/dL
- Use of supportive care measures (eg, use of white blood cell [WBC] growth factors, antiemetics, epoetin) should follow the ASCO guidelines as listed at www.asco.org. Participants should receive full supportive care, including transfusion of blood as mandated by clinical need; however, transfusions administered for the sole purpose of meeting the study inclusion criteria between the time informed consent is signed and first dose of EC145/placebo/PLD is administered are not allowed.
- Hepatic: Total bilirubin level < 1.5 x ULN and ALT, AST, GGT, and alkaline phosphatase levels < 2.5 x ULN.
- Renal: Serum creatinine level ≤ 1.5 x ULN or for participants with serum creatinine levels above 1.5 x ULN, creatinine clearance ≥ 50 mL/min/1.73m^2
- Cardiac: Left ventricular ejection fraction (LVEF) equal to or greater than the institutional lower limit of normal.
Exclusion Criteria:
- Patients refractory to primary platinum therapy where "refactory" is defined as disease progression within 6 months of first dose of initial platinum-based therapy.
- Diagnosis of "tumor of low-malignant potential".
- Prior exposure to PLD or anthracycline therapy.
- Prior exposure to FR-targeted therapy (eg, EC145, EC0225, EC0489, farletuzumab).
- Prior therapy with vinorelbine (Navelbine®) or vinca-containing compounds.
- Prior abdominal or pelvic radiation therapy or radiation therapy to > 10% of the bone marrow at any time in the past or prior radiation therapy within the past 3 years to the breast/sternum, dermal lesions, head or neck.
- Recent (i.e., ≤ 6 weeks) history of abdominal surgery or peritonitis
- Serious comorbidities (as determined by the investigator) such as, but not limited to, active congestive heart failure or recent myocardial infarction. Patients who require antifolate therapy for the management of comorbid conditions (e.g., rheumatoid arthritis) will be excluded from the trial.
- Pregnant or nursing.
- Concurrent malignancy requiring therapy (excluding non-invasive carcinoma or carcinoma in situ).
- Symptomatic central nervous system (CNS) metastasis.
- Other concurrent chemotherapy, immunotherapy, radiotherapy, or any ancillary therapy that is considered to be investigational (i.e., used for non-approved indications(s) and in the context of a research investigation). Use of low dose corticosteroid therapy (e.g., for nausea prophylaxis) is acceptable; however, concomitant tamoxifen therapy is not. Supportive care measures are allowed.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01170650
Study Director: | Binh Nguyen, MD | Endocyte |
Additional Information:
Responsible Party: | Endocyte |
ClinicalTrials.gov Identifier: | NCT01170650 History of Changes |
Other Study ID Numbers: |
8109-002 EC-FV-06 ( Other Identifier: Endocyte ) |
Study First Received: | July 7, 2010 |
Last Updated: | August 3, 2015 |
Keywords provided by Endocyte:
cancer ovarian platinum-resistant |
Phase III EC145 EC20 |
Additional relevant MeSH terms:
Ovarian Neoplasms Endocrine Gland Neoplasms Neoplasms by Site Neoplasms Ovarian Diseases Adnexal Diseases Genital Diseases, Female Genital Neoplasms, Female Urogenital Neoplasms Endocrine System Diseases |
Gonadal Disorders Doxorubicin Liposomal doxorubicin Antibiotics, Antineoplastic Antineoplastic Agents Topoisomerase II Inhibitors Topoisomerase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action |
ClinicalTrials.gov processed this record on March 28, 2017


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The Windows 8 Consumer Preview is out, and along with it, a (limited) number of preview apps that are designed to showcase the new Metro style (Figure A). Some of them work better than others.
Figure A
Windows 8 preview apps provide an early taste of what Metro can do.
Various apps, such as Mail, Messaging, Camera, Maps, People, Reader, Weather, and IE, come pre-installed. And there are almost 100 free apps available in the Windows Store (Figure B), which is itself the "mother of all apps" because that's how you get more. There are no paid apps at this time, since the operating system hasn't been released. It's important to remember that the apps, like the OS, are not yet in final form.Figure B
Windows Store: The "mother of all (additional) apps.
Here are my current five favorite preview apps out of the selection available, both pre-installed and downloadable from the Store.
Note: This list is also available as a photo gallery.
1: People
This is a lot like the People hub on Windows Phone; it connects to multiple social networks (Facebook, Twitter, Windows Live, LinkedIn, Google) as well as to your Exchange account and lets you see what your friends are posting regardless of where they're posting it (Figure C). It also serves as the source of contacts for the built-in Mail and Messenger apps. It's nice that these work together and you don't have to deal with multiple contact lists. You can send email or an IM to someone directly from the People app, too.Figure C
The People app shows you what's new with your contacts across multiple services.
2: Remote Desktop
I've been a big fan of the Remote Desktop feature since it made its Windows client-side debut in Windows XP, so it's no surprise that one of my most-used apps in Windows 8 is Remote Desktop (Figure D). It's quick and simple to use, and I think it's going to be a killer app on Windows 8 tablets. I tried several Remote Desktop Protocol (RDP) apps on the iPad and Android tablets and none of them worked very well.Figure D
The Remote Desktop app is clean and simple and gets the job done.
You can set the properties for all Remote Desktop connections or you can do it on an individual basis. To do that, you right click the connection whose properties you want to change and select Edit from the options bar at the bottom of the screen.
3: The Tower by American Airlines
Okay, this one is just plain cool. I'm an aviation buff so maybe that colors my opinion, but I love it. I hope they add more functionality to it in future iterations, but for now I just like the way it looks sitting there on my monitor (Figure E). The Tower lets you check the status of flights, find out where a flight in the air is at the moment, and get the weather and gate postings for AA hub airports.Figure E
The Tower makes you feel as if you're an air traffic controller — without the stress.
You start by selecting your hub (in my case, DFW). Then you can see the AA flights scheduled for the different terminals. They're color coded to indicate their status; on-time flights are green, delayed flights are red, and empty flights are black. You can see the number of departing and arriving flights, as well. Select a flight and you can see details such as the arrival and departure terminals and gates, flight duration, type of aircraft, even whether Wi-Fi is available on the flight.
4: YouCam
A built-in camera app (named Camera) comes with Windows 8 CP, and it works fine: Click the mouse or press, and it takes a photo with your Web cam. It's very basic, though. You can crop the picture and adjust a few basic settings, but that's all.
YouCam (Figure F) provides a bit more functionality. With it, you can zoom in or out, quickly adjust the brightness without going into menus, apply special effects (distortions, overlays, emoticons, frames), and switch from front to rear camera (if your device has both).Figure F
YouCam gives you more creative tools than the built-in camera app.
5: SigFig
Windows 8 CP comes with a Finance app you can use to keep watch on the ups and downs of your favorite stocks, but SigFig (Figure G) does much more. With it, you can import the accounts from your brokerages (using bank-level security) and track your entire portfolio, with detailed analytics and investment recommendations.Figure G
SigFig was a winner in the Windows 8 First Apps contest.
More on Windows 8
- Five reasons businesses should adopt Windows 8
- Windows 8 fails to wow CIOs, at least so far
- The Windows Explorer ribbon in Windows 8 is ready for prime time
- It's the Little Things: Windows 8 Both Delights and Infuriates
- Windows 8 Consumer Preview Embraces the KISS Principle
Other favorites?
Which Windows 8 preview apps have caught your eye? Share your picks with fellow TechRepublic members.
Full Bio
Debra Littlejohn Shinder, MCSE, MVP is a technology consultant, trainer, and writer who has authored a number of books on computer operating systems, networking, and security. Deb is a tech editor, developmental editor, and contributor to over 20 additional books on subjects such as the Windows 2000 and Windows 2003 MCSE exams, CompTIA Security+ exam, and TruSecure's ICSA certification.

subset: commoncrawl


text:
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... to resin type. For brown, gold, grey and black use Amber resin and for white and light, use Clear. | ..once the stone is in place and dry, pour the resin over the surface and leave to dry. | ...if you would like the stone to return to a dry, matt finish you are done. For a gloss finish you will need to roll a gloss coat. |
Why Choose Pouron |
Sick and tired of loose gravel but love the natural look it creates? Don't give up on your design dream - just use Pour On Gravel Binder. Whether you already have the stone in place and it is proving to be a nightmare with kids and dogs kicking it around (or eating it, yes that is a common reason given when purchasing) no worries you can retro fit over your existing pebbles.... Or if you want to create a brand new pathway, using Pour On is easy and the results will be amazing. Just head to our installation guide to see how easy it is to do. |
Application couldn't be easier - you spread your stone, pour the resin and leave it overnight for the magic to happen. The next day you'll have an outdoor paving area ready for use. |
Call Us: 1300 392 155


text:
Roughly two years after the launch of the ReWalk, Argo Medical Technologies is getting ready to refresh its assisted walking exoskeleton. The 2.0 version of the ReWalk's Rehabilitation model made its debut today, sporting a new Rapid Exchange slider that makes it easier to size the device to fit wearers in the physical rehabilitation settings for which it was built, making it easier to use the device with a number of different patients. Also new is the Beginner Gait Mode — revamped software aimed to soften the learning curve for those new to the device. The Rehabilitation is one of two ReWalk models offered up by the company. Its counterpart, the ReWalk Personal, is, as its name implies, intended for home usage. That model is currently awaiting FDA approval here in the States. More info on the new exoskeleton can be found after the break in the form of a handy press release.
ARGO Medical Technologies Unveils Advancement of its Exoskeleton Technology with Launch of ReWalk Rehabilitation 2.0
ARGO Medical Technologies has unveiled the newest generation of its ReWalk Rehabilitation exoskeleton that enables individuals with spinal cord injuries the ability to walk again. The 2.0 system is designed to make it easier to treat multiple individuals each day, it also has new software features that support beginner users and new sizing that allows each system to fit a broader range of patients.
ReWalk Rehabilitation 2.0 Highlights:
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If you looking for an Guest House or accommodation in jodhpur (The Suncity /blue city) ? So no further than the... Más información »
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text:
Warren Wade
School: Georgia Institute of Technology
Are you here to participate in one of our current school-based festivals? If so, choose your school and follow the instructions:
School: Georgia Institute of Technology
What happens when a couple of no good young whippersnappers begin using bananas to complete their fiendish deeds of stealing from students? Watch as the police force and a banana goddess... more
date posted: 2010-07-14 | views: 125 | type: Movie
A student trapped in an impossible class finds herself training for a dance off against her tyrannical professor to get an A in the course. Heavily inspired by Rocky--only instead of one... more
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IFSC Code of STATE BANK OF INDIA (SBI) Hulimavu Bangalore branch - Bangalore. Contact phone number and address
Find IFSC Code using the Lists below...
First select your bank, select the state, now select your district and finally select the branch of your bank to find IFSC Code. If you need to change any search list term, please use Up Arrow Icons.
Use the brown circle icons and drop-down menus below to change your bank or location.
IFSC Code Details and Hulimavu Bangalore Branch Information
STATE BANK OF INDIA - HULIMAVU BANGALORE is located at KARNATAKA state, BANGALORE district, BANGALORE city and the bank branch's address is [#5 & 10, ASK MANSION, SYNDICATE BANK COLONY, BANNERGHATTA MAIN ROAD,BANGALORE,560076]. Contact phone number / numbers - 9449875618. The IFSC Code is SBIN0014951. Branch code is the last six characters of the IFSC Code - 014951. Individual bank branch's details are listed below.
Bank :
State Bank Of India
State :
District :
Branch :
Hulimavu Bangalore
IFSC Code :
SBIN0014951 (5th character is zero)
Branch Code :
014951 (Last 6 Characters of the IFSC Code)
City :
Address :
#5 & 10, Ask Mansion, Syndicate Bank Colony, Bannerghatta Main Road,bangalore,560076
Contact :
Nearest State Bank Of India branches in Bangalore
Disclaimer : All the informations are provided with care. But please read our disclaimer before using informations from this website.
Banks List with IFSC Code
Hulimavu Bangalore branch information
Indian Financial System Code, Magnetic Ink Character Recognition, SWIFT Code, Address and Contact number of STATE BANK OF INDIA (SBI) - Hulimavu Bangalore branch. Branch office / ATM location : #5 & 10, Ask Mansion, Syndicate Bank Colony, Bannerghatta Main Road,bangalore,560076
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The best way to learn SPSS is with an expert. Wyzant is the world's leading network of private tutors, helping more students in more places than anyone else. And if you're not happy with your first hour with any new tutor, we'll gladly refund your money. Besides SPSS tutors, Wyzant can also connect you with:
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Search for in the Packages This site (using Yahoo!) Developers Developer mailing list General mailing list SVN commits mailing list
float|PEAR_Error Math_Complex::arg ( )
This package is not documented yet.
returns A floating point number on success, a PEAR_Error otherwise
No exceptions thrown.
This function can not be called statically.


text:
Top News:
Fox Sports:
Sources: Marlins broke promises — Miami Marlins fans are not the only ones feeling betrayed by ownership's decision to break up the club. — Shortstop Jose Reyes and left-hander Mark Buehrle, two of the five Marlins headed to Toronto in a pending blockbuster, are upset …
baseballmusings.com, Amazin' Avenue and HardballTalk
Peter Gammons / MLB.com:
Stanton solely focused on 'winning philosophy' — Marlins slugger frustrated after five teammates traded to Toronto — Giancarlo Stanton was home in Westwood, Calif., on Tuesday when he heard the news that five of his teammates were being traded to the Toronto Blue Jays.
HardballTalk and Miami Marlins
Joe Capozzi / Fish Tank blog:
Ricky Nolasco will pitch for Marlins in 2013, says team president
Ricky Nolasco will pitch for Marlins in 2013, says team president
The LoHud Yankees Blog
Fox Sports:
Mets may be close on offer to Dickey — The New York Mets could be on the verge of a breakthrough in their negotiations with National League Cy Young Award winner R.A. Dickey. — Or, maybe not. — The Mets plan to offer Dickey a two-year contract extension, according to major league sources.
Metsblog, Newsday and HardballTalk
David Lennon / Newsday:
Bud Selig gives Fred Wilpon's ownership group a vote of confidence
Bud Selig gives Fred Wilpon's ownership group a vote of confidence
Buster Olney / ESPN.com:
Wilpons should re-sign Dickey or sell Mets
Wilpons should re-sign Dickey or sell Mets
New York Post, Metsblog and MLB Rumors
Adam Kilgore / Nationals Journal:
Nationals have talked with B.J. Upton — As the Nationals wait for a resolution to their ongoing talks with first baseman Adam LaRoche, they have had initial dialogue with free agent outfielder B.J. Upton, according to a person familiar with the situation, and are expected to have increased communication with Upton in the near future.
HardballTalk, MLB Daily Dish and Phillies Nation
Fox Sports:
Market heats up for B.J. Upton — The full-court press is on for free-agent center fielder B.J. Upton. — Upton not only met with the Atlanta Braves on Thursday, but also spoke with the Philadelphia Phillies earlier in the week, according to major-league sources.
Mark Bowman / Bowman's Blog:
B.J. Upton visits with Braves at Turner Field
B.J. Upton visits with Braves at Turner Field
MLB Rumors, Federal Baseball, Baseball Nation, HardballTalk and MLB Daily Dish
Ben Nicholson-Smith / MLB Rumors:
Blue Jays To Sign Melky Cabrera — The Blue Jays have agreed to sign Melky Cabrera to a two-year, $16MM contract, Enrique Rojas of ESPNdeportes.com reports. ACES represents Cabrera, who must pass a physical for the deal to be completed. — Cabrera served a season-ending 50 game suspension under …
WEEI, MLB reports, FanGraphs Baseball, baseballmusings.com and Batter's Box Interactive …
Sources: Toronto close to naming new manager — The Toronto Blue Jays are close to announcing their next manager less than a month after John Farrell left for the same position as part of a trade with the Boston Red Sox, sources have told ESPN The Magazine's Buster Olney.
MLB Rumors, Purple Row, ESPN, Red Reporter, Bucs Dugout, MLB and Associated Press
Greg Johns / MLB.com:
Zduriencik says Mariners aren't targeting Hamilton — SEATTLE — Although the Mariners plan to pursue offensive upgrades this offseason, general manager Jack Zduriencik said Friday he doesn't see Seattle being big players in the pursuit of free-agent slugger Josh Hamilton.
HardballTalk, Lookout Landing and MLB Rumors
John Manuel / Baseball America:
Brazil Upsets Host Panama In Qualifier Opener — Astros farmhand Murilo Gouvea retired the first 10 batters he faced, and Rays farmhand Leonardo Reginatto scored two of Brazil's runs and drove in a third as Brazil upset Panama 3-2 to open the World Baseball Classic qualifying tournament.
Bleed Cubbie Blue
Adam McCalvy / MLB.com:
Science gives Crew edge in keeping arms healthy — Injury prevention for pitchers is focus of team's unique three-day medical symposium — MILWAUKEE — For nearly a decade, the Brewers quietly have been on the forefront of injury prevention, particularly in the pitching department.
Dick Kaegel / MLB.com:
Trout is Negro Leagues Legacy Awards' AL MVP — Pirates outfielder McCutchen receives National League's top honor — KANSAS CITY — Mike Trout settled for runner-up when the Baseball Writers' Association of America announced its choice for American League MVP on Thursday …
Pinstriped Bible
Mark Saxon / ESPN:
The LoHud Yankees Blog and River Avenue Blues
Mark Berman / MyFoxHouston:
Astros owner Jim Crane meets with Lance Berkman who is working as volunteer at Rice — Houston Astros owner Jim Crane told FOX 26 Sports he met last week with free agent first baseman Lance Berkman. — "We had a chat in my office," Crane said. "He was just seeing where we were at.
MLB Rumors, MLB Daily Dish and HardballTalk
Ben Nicholson-Smith / MLB Rumors:
Padres Acquire Ross For Parrino, Werner — The Padres announced that they acquired right-hander Tyson Ross and infielder A.J. Kirby-Jones from the A's for infielder Andy Parrino and left-hander Andrew Werner. None of the four players have enough service time to be arbitration eligible.
Mercury News, MLB Daily Dish, Athletics Nation and Baseball America
Dave Studeman / Hardball Times:
It's the 2013 Hardball Times Baseball Annual — The Hardball Times Baseball Annual for 2013 is now yours for the purchasing. This is something we do every year, just for the heck of it. In fact, this is our ninth THT Annual, and we're trying a few new things this year.
DRaysBay, Getting Blanked and Beyond the Box Score
Rob Bradford / WEEI:
SOURCE: RED SOX NOT PRIORITIZING HAMILTON — According to a baseball source, reports of the Red Sox' interest in free agent outfielder Josh Hamilton have been "overblown." — While the Red Sox are in the market for a pair of outfielders this offseason, Hamilton — considered …
Full Count, Over the Monster and HardballTalk
Joe McDonald / ESPN:
Sources: Red Sox to talk extension for Pedroia
Sources: Red Sox to talk extension for Pedroia
Over the Monster, Fire Brand, Boston Globe, MLB Rumors, Associated Press, HardballTalk and Full Count


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text:
- lists
- blocks
Common words appear frequently in written and spoken language across many genres from radio to academic journals.
Informal words should be reserved for casual, colloquial communication.
More words related to nimbly
adv. actively; intently
- indefatigably
- industriously
- laboriously
- like all get out
- like the devil
- like the dickens
- nimbly
- painstakingly
adv. with great speed
adv. gently, effortlessly
adv. energetically
adv. in a dexterous manner
Roget's 21st Century Thesaurus, Third Edition Copyright © 2013 by the Philip Lief Group.
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i appreciate everybodys opinions and sharing the knowledge and or stories.... i know the 327 was pretty stout back then but i guess in these new days people are running 355 and 383's , 406's all over the place....
Do some research and reading in your spare time (not meant sarcastically).
Check out Chevrolet small-block engine - Wikipedia, the free encyclopedia The 283 was an overbored 265. The 327 was a stroked and overbored 283. Hence the reason for the early small journal 327's. I think GM realized they could restroke the 4.00" bore 327 to 3.48 without any block clearance issues, so why not take advantage of the longer stroke and rod to stroke ratio and build 350's. I've read in several places (not known to be fact) that the 307, that came out in '68 was the result of alot of 283 blocks 'laying around' at GM that could use the newer 327 cranks. And, again from what I've read, the 302 was a response to racing displacement rules. Now, for the 400, I don't know, maybe GM wanted lead the pack for small blocks. Of course this is my opinion. But one thing that GM did was maintain a very similar platform that led to alot of interchangeable components amongst different displacements and model years, which is real good for us and made the SBC very cheap to build. For example, check out the pricing on building a stage II or stage III 455 Buick or hot 340 or 383 Mopar. AGAIN, just my opinion. |
327 Vs 350
Back in the early 60s,maybe some of the other guys remember better than me. GM built 5 x377 cube stroker small blocks for the vette racing program.I think they were put in a 63 vette? over in Europe the Germans were well into developing fuel injection for their road cars and were able to find more power that way,better mileage was more important in Europe than here. R&D will try many things and market some of the successes The 350 chevy came out in 1967 in the Z-27 Camaro.not sure what the 396 was designated as? the 302 of course was Z-28 sorry,useless bits of info tossed in a random order |
The Chevy 302 (301 as it was called in the day) engine was a 283 CI engine bored to 4".
The SB Chevy 283 engine bored out to 301 CI was the top dog SB Chevy engine until Chevrolet introduced the 327 CI engine in 1962. My first street machine when I graduated high school was a yellow '56 Chevy Del Ray 2-door sedan with a 265 CI Power Pack engine, 3-speed with OD. I rebuilt and installed a 1957 Chevrolet 283 CI engine in the '56 Chevy. My 283 CI engine was bored to 4.00" for 301 CI and I installed a 4.56:1 rear gear. I wrecked my '56 Chevy on December 23, 1962 and installed the 4.56 rear end in my 1959 Impala 2-dr. HT with a 4-speed. |
'Sounds like your 'day of infamy' . I can only imagine the sadness. But personally, I'd rather have the '59 Impala, but I would guess that you weren't thinking that at the time. There wasn't too much cooler than those big boat tails
My '56 Chevy Del Ray was MINT, even for 1962. It was equipped with a 3-speed floor shifter from Honest Charley Speed Shop and a Sun 5000 RPM tachometer mounted on the steering column. I rolled it on a icy road two days before Christmas 1962. I bought a beige 1959 Impala 2-dr HT with a 283 engine and a 4-speed six months later with a $500 loan for the down payment from my father. I salvaged the 4.56 Posi rear end and later used it on my '59 Impala. The only engine parts I salvaged from my '56 Chevy was a pair of Corvette valve covers.
Of all the cars I have owned, I liked my lemon yellow '56 Chevy Del Ray the best. It came from the factory with a 4.11 rear end because it had 3-speed transmission with OD. I replaced the 4.11 open rear end with a 4.56 Posi Traction using new GM ring and pinion gears. |
Don't believe everything you read on the web!!
Yes, A 283 is like a bored 265, a 302 is like a bored 283, and a 327 is like a bored 265 or 283 and on to the 350 But if you read that on the web you would think a 350 is a bored 265 block casting! The easy way to build a "301" is to use an early 327 and a 283 crank. We did that in the 60s but that's not the 302 of legend. DZ302 and YZ302 When you see fully machined blocks from machinist on the web passing off there 3932386 casting converted 327's & 350s As Genuine Z28 DZ YZ 302's,LT1's,High Perf. 300 350 370 375HP 350's ask them what the #'s on Main caps are. If there Not the Nodular Forged (Denoted by the Capped letters "NF") "2482"s then they are FAKE! Camaro Hi-Performance: Vehicles: The Old Reliable Jerry MacNeish and the legendary Bill "Grumpy" Jenkins at the 1994 NHRA Keystone Nationals, Maple Grove, PA. TECHNICAL DATA VIN number 124378N411100 Build Date 04A (first week of April) Color Corvette Bronze Interior Code 712, black standard Car Shipper Shipped on April 11, 1968 to Ammon R. Smith Auto Company, York, PA Engine Data Cubic Inches, 302 Cylinder heads #3917291, completely stock, no porting allowed! Stock rocker arms & valve springs Intake 302 aluminum intake, casting #3917610 Carburetor Holley, #4053, 780 CFM 4bbl Camshaft Crane, .480 inches lift, 272 degrees duration, valve lash, .016-.016 Pistons GM 302, .030" oversize Horsepower 456 @7700rpm Rear Tires 9" x 30.0" Hoosier's Rear axle & ratio 12-bolt, 5.57 Richmond Pro Gears Clutch 10 inch, three finger from Advance Clutch Technology Shift Points 8200 RPM BEST ET 10.80 @122.30mph 05 stock champion That's old skool: Stock class stock heads' stock rockers and springs, Shifting at 8200, 456 hp 7700rpm and still will make your heart stop today! Thus called a legend!!! Jester |
IMO: Don't forget in the beginning of 1970, Emission level was getting tighter it was coming into play.
That is why a 283 was replaced with a 307, 327 was replaced with a 350, 427 was replaced with a 454. And the 305 has a smaller bore but same stroke as the 350. It seem the longer stroke motors produce less emission. Chevy was in a hurry of building 302 for trans-am racing that was limited to 305. that's another story. Because of cars were getting heavy chevy needed a longer strokes motors in order of getting more torque. |
yes it was, remember back when the 327/350 came out.. the tire tech wasn't what it is today.. today we are spoiled with rubber that even slicks of the day didn't have..
the 327 lack of hugy low end helped it. get the car out of the hole.. and the rpm range worked great with the transmissions aval. then.. 2speed powerglide or 4 speed wide stick.. I've driven both a 327 and 350 vettes with sticks.. and the 327 was way more fun.. |
I saw a test comparing a stock high hp late model Vette with a 67 Vette ( I think an L 88?) in the 1/4 and 0 to 60 times! The new Vette beat out the 67 but the 67 had stock tires 7 inch tread the new vette had stock tires but with a really wide tread and it also had stock traction aids that the early Vette didn't come out with!! I watched that and thought it was so unfair!!!!!
Its like the stock factory muscle cars of the 60s, and 70s they came out with stock tires of a tread pattern of 6 to 7 1/2 inches with bare bones suspensions, The new muscle has big tires big tread,traction aids etc ! and to compare the 2 to 1/4 and 0-60 times with data from 60s and early 70's compared to new car test data today is Ludicruse! But you see it over and over again Jester |
My associate, Randall Brock, purchased a slightly used 1967 Corvette 427 L88 in 1969 for $6,000!
I drove his 1967 Corvette 427 L88 a few times and it was the fasted street driven vehicle I have ever drove or even rode in. The Corvette could turn 11.00 sec. ETs consistently with some good bite. R. Brock also owned a 1969 Dodge Charger with 426 Street Hemi with an automatic transmission and his L88 Corvette could blow the Charger's doors off. Randall Brock's 1967 L88 Corvette 427 CI engine 430 HP at 4600 RPM (advertised) 560 HP at 6400 RPM Total production: 20 (14 known to exist today) 850 CFM Holley double pumper Cast iron heads White with black interior Convertible No radio available No spark plug static shields M22 Muncie 4-speed K66 TI ignition Side pipes 4.56 Positraction Built at the St. Louis MO Assembly plant The unconfirmed rumor was that Brock's 1967 L88 Corvette was ordered by the TV host Dick Clark but when it arrived without a radio, Clark refused to accept it. In 1971, Randall Brock traded his '67 L88 Corvette roadster for a 1967 Pontiac Firebird 400 convertible which I acquired a year later . The '67 Firebird had 3500 miles on the odometer. The new owner of the '67 L88 Corvette lived in San Antonio TX and he turned it into a race car and it was never licensed again. It has disappeared from history. Last edited by MouseFink; 02-08-2013 at 05:26 PM. |
But. In the real world often the relationships and dimensions of component just don't work together, one could think 312 Y block Ford as an old example. Other times you just hit it. The 327 was one of those times, it seems the 4 inch bore in any engine is a gift that allows valves big enough to feed the cylinder. To me it's almost a magic dimension; it's hard to think of a poor running 4 inch bore motor from any manufacturer. Sure you can load 'em up with emissions and mess them up, but generally they've proven to be a family of well, if not superlative, performance engines. All 327s have a good rod length to stroke ratio, the performance engines got forged cranks; they also got well proportioned to slightly large ports, big to bigger valves, high compression dual quench heads. Just a lot of stuff that works well together. But against an equally prepared larger engine like the 350 the 327 and 302 for that matter need to have a drive train that adjusts for their need to turn more RPM for equal power. So the end result is as much matching the vehicle and driveline characteristics to the engines characteristics. One has to keep in mind the primary driver behind engine size evolution is the need for more torque to move grocery getters, sell these is what pays the bills over at GM, Ford, and Chrysler. Performance sells to pretty small crowd so even if mom and pop came in to the dealer on Monday following some big national raceway win the preceding Sunday; it was more likely they left with a 250 horse 327 in a station wagon than a 360 horse 327 in a Corvette. So the performance arm of the company most always makes due with what's up for mom and pop production. So as the 283 was a torque search over the 265, the 327, 350, and 400 were from the same intention on the part of Chevy; more torque to cruise more weight and power consuming gadgets. I won't even comment on some the stuff they went to in the interest of emissions like 262 or 267, these tiny bore motors are attempts to use Voodoo to solve engineering problems and everybody went down that road to the same end. Bogie |
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39 U.S. Code § 1204 - Elections
§ 1204.
All elections authorized under this chapter shall be conducted under the supervision of the National Labor Relations Board, or persons designated by it, and shall be by secret ballot. Each employee eligible to vote shall be provided the opportunity to choose the labor organization he wishes to represent him, from among those on the ballot, or "no union".
In any election where none of the choices on the ballot receives a majority, a runoff shall be conducted, the ballot providing for a selection between the 2 choices receiving the largest and second largest number of valid votes cast in the election. In the event of a tie vote, additional runoff elections shall be conducted until one of the choices has received a majority of the votes.
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For household budgets, organic doesn't always pay off
If you see a $3 organic avocado for sale, put your Hass-squeezing fingers in your pocket and keep shopping.
Plenty of Orange County shoppers select the best fruits and vegetables they can find, especially in the summer, when kids are home and there's still an abundance of selection at the markets. For many health-conscious consumers, buying the best usually means buying organic.
But why does organic have to cost so much? Various estimates say produce grown without pesticides can cost up to 50 percent more than the conventionally grown, on which chemicals are used to kill bugs, fungi and other enemies.
"It's the biggest challenge," said Michele Whiteaker, a mother of two from Laguna Hills who writes the mom blog FunOrangeCountyParks.com. "Parents are the ones who really want to see their children the most healthy, but we're probably the most restricted on budget."
At the Whole Foods Market in Laguna Niguel last week, organic seedless grapes were on sale for $3.99 a pound; at Trader Joe's in Laguna Hills, the same item cost $2.99 a pound; at an Albertsons in Orange, a pound of nonorganic grapes went for $1.99 a pound.
Even the most fervently pro-organic advocates acknowledge that fresh fruits and vegetables are safe whether they're organic or not. But prices can vary widely from item to item, store to store. One answer is to pick your food carefully, because the label "organic" is more important for some foods than others.
A lot of it has to do with the thickness of the skin, which makes sense: Foods that have an outer layer that we don't eat – like pineapples, bananas and, yes, avocados – don't necessarily need to be organic, because we're going to throw away the skin. Ditto for foods that we peel such as carrots and onions.
Pesticide residues tend to stick more often to soft-skinned foods, like berries, nectarines and sweet bell peppers, or on leafy greens like lettuce and kale.
"Strawberries are so porous that they absorb whatever's around them," said Anna Soref, a natural-foods writer from Ohio who consults for many natural-products companies. "That's one fruit on the list that you always really want to try to get organic."
When the nonprofit Environmental Working Group released its "Dirty Dozen" list of the foods that contain the highest number of pesticides, strawberries once again were high up there, at No. 2. At the top are apples, with grapes coming in third, celery fourth and peaches fifth.
The group also publishes a "Clean 15" list, with many of the thick-skinned foods on it, including No. 1 asparagus, followed by avocados, cabbage, cantaloupes and sweet corn.
Farmers, particularly conventional ones, hate the list, calling it misleading. They say just because a food item has pesticide left over after it's harvested doesn't mean it's unsafe to eat. They recommend washing food before eating. But they add that virtually all foods grown conventionally, even with pesticide residue, contain them at levels far below the threshold of safety set by the Environmental Protection Agency.
"We recommend consumers enjoy eating both" organic and conventionally grown food, says Teresa Thorne, spokeswoman for the Watsonville-based Alliance for Food and Farming, a trade group representing both types of farms.
"Both are very safe," she added. "Both production systems and their farmers do a very good job of providing safe food. And the best thing you can do is eat fruits and vegetables, whether organic or conventional. Our goal is to get people to consume more. And our goal is to make sure people aren't scared away from fruits and vegetables with information that is not science-based or credible."
In fact, EWG uses the same data the farmers use – the annual summary published by the USDA's Pesticide Data Program. In February, it released the measurements from 2011. Of the 11,894 samples taken, only 32 exceeded the tolerance established by the EPA. That's less than one-third of 1 percent.
"What we urge people to do is look at the actual USDA and EPA data, and not the EWG's manipulation of that data," Thorne said.
One flaw in the most recent report is that it doesn't include apples or strawberries, which the USDA last sampled from January 2008 to December 2009.
The EWG, on its website, says, "Eating conventionally grown produce is far better than not eating fruits and vegetables at all." But it notes that hard data about the effects of long-term exposure to pesticides in the body is lacking.
Soref says the price of organic actually has come down a bit, as mainstream supermarkets stock more of it to satisfy increasing customer demand. But there are a lot of costs associated with organic farming that the public never sees.
For one, it's more labor-intensive, and the natural-based insecticides and anti-bacterials allowed for organic farms can cost a lot more than the synthetics used by traditional farms.
Certification, by the National Organic Program (which is run by the USDA) and California Certified Organic Farmers, can bring extra expenses, as well. For instance, land must remain free of conventionally grown crops for three years before seeds labeled organic can be planted. In Orange County, it can be prohibitively expensive to let a patch of land lie fallow for that long, generating no income.
"There's just not that much land available," said Anne Manassero, who has run Manassero Farms with her husband, Dan, since 1976. They have plots of land in Brea, Cerritos, Irvine and Tustin, growing corn, strawberries, tomatoes and other crops.
At the miniature red barn in Tustin, surrounded by a tiny corn field, customers poked through boxes of fruits and vegetables. Betty Hinchman of Dana Point got out of her white Beemer and went straight for the strawberries. A friend's daughter was about to get married, and she needed some choice ones for chocolate-dipping. She paid $19 for a 6-pint "half flat" of strawberries, about the same as the strawberries down the street at Vons.
Hinchman said if she sees "organic" on the label, "it usually means I don't buy it. ... It's just not a big issue for me."
She might have been surprised to know that she just bought organic. The strawberries were grown organically, but the word "organic" doesn't appear on the box.
Sometimes, you pay for the label.
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El Mar Restaurant
Next to Isla Grill restaurant you can find restaurant El Mar. Our restaurant "al fresco" concept: wood oven and grill provide a perfect offer in a casual and laidback ambiance while you enjoy the stunning ocean views. A gourmet tasting breakfast is available every morning for you and your companion. Dishes such as tostadas, quesadillas , sandwiches, paninis, meat and fish grilled, brochettes and of course delicious thin crunchy pizza just taken out of the oven would not be missed for lunch time. And for dinner, a la carte menu is served, where the preferences and likes of our guests are fulfilled. All of this makes an unforgettable experience in a unique setting.
Our tip, ask for the bonfire party at night time and you will not regret.
Breakfast open from 07.00 am – 10:30 am
Lunch open from 11.00 am – 05:00 pm
Dinner open from 6.30 pm – 10:00 pm
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Casual elegance for gentlemen: Long pants or bermuda, collar shirt, casual shoes and elegant sandals must be worn. Swim suit, t-shirt or tank shirt, beach sandals and sleeveless shirts are not allowed.
Casual elegance for ladies: Long pants or bermuda, Capri pants, skirt, blouse, casual shoes and elegant sandals must be worn. Swim suit, t-shirt and beach sandals are not allowed.


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Hare-kon Chapter 19 Page 1
You are reading Hare-kon Chapter 19 Page 1 on MangaSee.
To see more information about this Manga, please visit the Chapter List.
Hare-kon is a Manga that was published in 2014by NON.
Hare-kon Manga is Ongoing.
Its scanslation status is Ongoing.
Hare-kon Chapter 19 was added on .
Genres: Comedy, Ecchi, Harem, Romance, Seinen
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Full profile →'">
The author is a Forbes contributor. The opinions expressed are those of the writer.
Continued from page 1
"As an American I am of course fundamentally opposed to democracy and to anyone advocating or defending democracy, which in theory and practice is the basis of socialism. It is precisely democracy which is destroying the American political structure, American law, and the American economy, as [James] Madison said it would, and as [Thomas] Macauley prophesied that it would do in fact in the 20th century."
Some of us observed other frailties of the U.S. Constitution years later, but deluded ourselves into believing it was all just a consequence of inadequate constitutional design, which could be overcome and rectified with appropriate constitutional changes. Alas, it is impossible any longer to labor under the delusion that democracy can be fixed by tinkering with constitutions, appointing the right judges to the bench or electing the right politicians to office. As Frank Karsten and Karen Beckman have written in Beyond Democracy, democracy cannot be fixed because it is inherently broken:
"The problems of democracy are inherent. It's like having dinner with a million people and deciding up front the bill will be split evenly. Everyone has a strong incentive to order more than he would individually, resulting in a huge bill that everyone deplores but no individual could do anything about. Democracy therefore has a very limited self-cleansing capability. Our politicians have a natural short-term outlook since they are only temporarily in office. They will overspend, overtax and over borrow knowing their successors will have to deal with the negative consequences. Besides that, they spend other people's money anyhow."
But now we come to the hard part: What is to be done? If not democracy, what? If the ballot box won't work to reverse the arrow of democratic politics, if better constitutional design can't overcome democratic entropy, are we left with rebellion and revolution? History demonstrates that violence begets violence and the violent overthrow of tyrants begets new tyrannies, frequently worse than those they replace. Is peaceful rebellion feasible? Will non-violent, civil disobedience work to reorder our dysfunctional politics, and if so, what kind of "new order" is to replace the old order?
The fact is, we don't know how to structure society, and any effort trying to do so by constitutional/political/social engineering—no matter how well intentioned, no matter how smart the designers—inevitably leads to disastrous outcomes. The key, therefore, is not to think about replacing what we have with something else but rather to replace it with nothing, i.e., freedom from government, not enslavement to a new form of government.
The only way human societies can possibly develop successfully to satisfy the needs and desires of the individuals that make them up is through a process of gradual evolution, not juridical, legislative and bureaucratic incrementalism, but rather a social, political and economic evolution that occurs free of all three; a trial-and-error, evolutionary process where millions of free individuals work it out on a case-by-case, day-to-day basis at the individual level of bilateral trade, voluntary contract and discourse with each other. Coercive collective action in the name of the greater good not only is immoral—who decides who has the gun?—it also is destructive of human happiness and ruinous of human potential.
Therefore, the only "structural" device that holds forth true hope of facilitating and nurturing a market-like process of social, political and economic evolution is to constrain government and other coercive institutions in a way that allows individuals the freedom to escape, without prejudice, the clutches of any authority that would impose non-consensual, involuntary rules upon them.
That is why a true federalism—properly defined as the presence of alternative polities to which individuals can escape—is the greatest, indeed the only effective protection of human liberty. That is why contrary to James Madison's rationalizations for an extended republic , a geographically large, powerful central government will always become the most tyrannical. That is why I wrote a while back that the greatest hope to revive freedom and prosperity in America is for the states to rise up against the oppressive federal government, exert their sovereign powers and put Washington back in its rightful place—not a revolution but a restoration of the Old Federalist Republic. Not a call to take up arms but a call for states to just deny and defy federal authority.
Make no mistake though, such a call for a restoration of the Old Federalist Republic is not premised on any fallacious notion that the government closest to the people is the best government. To the contrary, Hunter's Postulate holds that the closer one gets to the individual, the more oppressive government becomes—try working in academia, existing under the thumb of a homeowners' association or living in an oppressive little backwater like Warrenton, Virginia if you don't believe it.
No, the virtue of a true federalism has nothing to do with the virtue, competence, or trustworthiness of local officials and the parasites they nurture but everything to do with the ability of people to escape their grimy little reach. Restrict the sphere of the monopoly to initiate violence (which is the true definition of government), and you increase the possibility of escape. Farmers in human cattle, which is all governments are, cannot survive if the livestock all walks off the plantation.
In the long run, then, exit—voting with one's feet—is the only guarantee against tyranny, which is the only reason to recommend the states rise up and overthrow the federal tyranny that characterizes the United States in the early days of the 21st century. Is it a panacea? No, but it probably offers the last exit before the cliff that our current system is headed toward.


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CITYDEAL様は99designsで ロゴ デザインコンペを開催しました。
CityDeal - CityDeal.de
Our company offers consumers restaurant, beauty (spa, cosmetic) and event deals at more than 50% off regular price. The deals are targeted to the user's city (e.g. London) and can be bought directly from our website.
The deals only run for 1 day. During this 1 day, a certain threshold of buyers needs to be crossed or the deals will not take place (e.g. if 20 buyers get the deal, it will take place). This encourages customers to recommend the deal to their friends via facebook, email and twitter. Also you do not go for a nice dinner on your own, so this encourages the social aspect as well.
Main target group is female and 25-45 years old. Mainstream with a potential slightly higher than average income. Our target group is very social and likes to mingle both online and offline. They want to visit nice restaurants, spa facilities or events while saving money at the same time.
• Logo should contain name of our company "CityDeal" (without quotations).
• We want the logo to be young, vibrant, fresh and highlight the social aspect as well as the savings/coupon aspect
• Logo should be a text logo with certain symbols mixed in to highlight the brand promise (see one bullet above)
• However the logo should also be not too playful (i.e. certain degree of serious CI).
• Font must be legible and clearly defined (no cursive or goofy script and not too small).
• Color scheme should broadly match the one currently used on http://www.citydeal.de (green, blue, white) - broadly match means that you should use green, white and blue but you can change the intensity, shade and colouring within those colors.
• Logo can be reproduced on a white or colored background but with clear contrasts.
• We will need all source files in all major formats. We need to hold the ability to alter colors at will and provide additional formatting at will (e.g. fully layered PSD-File).
• Ability of file to reproduce logo in all sizes.
• Usable for web and print.
• Must contain ONLY original work (no reuse of third-party material).
• Winner must transfer the copyright for the created artwork.


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IndyCar puts Helio Castroneves on probation through June
INDIANAPOLIS (AP) -- IndyCar has put Helio Castroneves on probation through June because he violated the series' social media policy.
Castroneves was penalized Tuesday for a tweet sent from his official account after the Long Beach, Calif., race on April 13 that criticized race control for not penalizing drivers during the race. The tweet included an image of IndyCar's official logo with a "thumbs down" symbol photo-shopped in the center.
The tweet was deleted not long after it appeared, and Castroneves later posted that his sister had sent the missive from his account without his permission.
"I apologize and the steward were correct with the call made," Castroneves posted.
Castroneves was fined $30,000 in 2011 for calling the race director "a circus clown" on Twitter.


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Unsure which build to use? Click the link for iPhone and iPad models.
How to install iOS 8 Beta without UDID registration:
Step 1: Connect your iDevice with iTunes via USB.
Step 2: Restore your iPhone, iPad or iPod touch to iOS 7.1.1 via iTunes, then setup it as a new iPhone
Step 3: Download iOS 8 Beta 2 for your iPhone, iPad or iPod touch
Step 4: Now your are requested to hold SHIFT and left click on "Check for Updates" on iTunes, then select iOS 8 beta 1 which you downloaded on Step 3, wait for few minutes and enjoy iOS 8!
iOS 8 Beta 2 Download links:
iPhone 5s (Model A1453, A1533)
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Big Data
Discover a world of big data with our selection of books and hardware.Moon Collection
Discover the moon with the Science Museum's range of moon and telescope products.Anatomy-inspired
Anatomy-inspired homeware, clothing, experiments and more.For Aspiring Chefs
Find kitchen gifts and gadgets for aspiring chefs.Tech Gifts
Find the perfect gift for tech lovers.Robots
Discover a different world inspired by our Robots exhibition at the Science Museum.Zaha Hadid Range
Discover the Zaha Hadid Range, designed by Zaha Hadid Architects and Design to celebrate Mathematics: The Winton Gallery.Wonderlab Collection
Find fantastic items inspired by Wonderlab: The Statoil Gallery and designed to encourage a wonder and love of science.IMAX Screen Collection
Take home a piece of cinematic history with the IMAX® Screen Collection.MSI + Peter Saville
Lab Glassware range by Peter Saville for the Museum of Science and Industry celebrates Manchester's three rivers and the iconic Hacienda dancefloor.Chemistry Sets
All you need to supply a budding laboratory-lover.Physics & Electronics
Discover the secrets behind magnetic fields, motors and more with physics & electronics experiments sets.Biology Sets
Explore the human body or experiment with DNA with these biology experiments.Microscopes
Explore our microscopes to examine all sorts of objects on a minute scale.Coding & Technology
Learn about computers, coding and technology for all ages.Key Stage 1 (Ages 5 to 7)
Set kids up with an interest in science from an early age with the Key Stage 1 collection.Key Stage 2 (Ages 7 to 11)
Help older children engage with science with Key Stage 2 collection.Key Stages 3+ (Ages 11+)
Older kids will love getting into science with Key Stages 3+ activities.Mugs
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President-Elect Spends Weekend Getting to Know SLU
Fred P. Pestello, Ph.D., president-elect of Saint Louis University, spent a weekend in St. Louis meeting with many University groups and stakeholders.
Following his introduction to the SLU community March 21, Pestello attended a news conference, as well receptions for faculty, staff and students. Throughout the weekend, he also met with several key University constituencies, including:
- March 21: The leadership of the Staff Advisory Committee.
- March 22: The outgoing and incoming leadership of the Student Government Association.
- March 22: The executive committee of the Faculty Senate.
- March 23: Deans of SLU's colleges and schools.
In addition, Pestello attended the student watch party for the Billikens' NCAA Tournament game on Saturday afternoon and the 10:30 a.m. Mass at St. Francis Xavier College Church on Sunday.
Visit slu.edu/president-elect for Pestello's biography and CV, as well as photos, videos, news stories and more.


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Keen Men's Portland Boot
Keen shares its Oregon hometown with some of the hardest working people the West has known. The ever-changing conditions of the region inspired this versatile, waterproof work boot that's as fit for hoisting girders in the sun as it is unloading a container ship in the driving rain. Crush-proof composite protects your toes without the cold of steel, making this one tough boot that's...
Keen Men's Detroit Soft-Toe Mid Boot
The motor city gave us the assembly line and a good share of the world's automobiles. The Detroit work boot from Keen reflects the solid work ethic of this through a versatile design that supports and protects every inch of your feet. So comfortable and easy to wear, you just might forget to take them off once your shift is through.
Keds Men's Chukka Boot
Keds updates its original Champion basic sneaker with a clean and hip chukka silhouette. This traditional kick offers a padded insole, adjustable lacing and breathable lining. It's a tried-and-true shoe that'll always be in style.
KEEN Men's Winterport II Winter Boot
Featuring the comfort and performance you've come to expect from KEEN, this Winterport II boot is also wrapped in a warm, waterproof membrane. The quick-draw elastic cord adjusts to a toasty fit, and the dual climate rubber outsole stays hard in the cold for a better grip on your wintry excursion.


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Skype Challenger O2 Enters Market with International Call Service
By VoipPlanet.com Staff | Apr 15, 2010 |
Print this Page
"Skype is set to get a very serious competitor in the realm of cheap international Voice-over-IP market as O2 has started taking orders for a new beta service that will allow unlimited international phone calls for a fixed fee,"writes ITProPortal's Desire Athow.
"The product, which is currently in beta, is called International Families and Friends Bolt On, and is available for Pay monthly and Pay & Go customers," writes Athow.
Click the link below to read the full article:
O2 Set To Challenge Skype With New Cheap International Call Service


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themodernfirm brauchte ein neues Logo Design und hat einen Wettbewerb auf 99designs gestartet.
Aus 170 Designs von 27 Designern wurde eine Gewinner gewählt.
Law firm that works with local governments and business entities needs a logo that will work for our website and print materials.
Hafeli Staran Hallahan & Christ, P.C.
The firm is having a new website designed and would like a new, professional logo to go with it. Currently the firm has only a self created logo.
The firm works with governments and businesses, so it should be classy, serious, established and professional looking. It needs to appeal to decision makers.
- Fits in a square area
- Adaptable to work with a wider layout as well
- Think we prefer a design that uses the HSHC initials
- Open to seeing other options that don't use HSHC
- Color scheme can be either Red/Black/Grey/White or Red/White/Blue/Black
- Unique, bold, clean
- Appeals to business people and government officials
- Will need vector format supplied
- Dated looking


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Umphreys Mcgee Tickets
The rock band, Umphrey's McGee is famously known for its extensive touring and mind-blowing live performances. They have hit the road and will soon be coming to perform in an arena near you. So be ready to enjoy timeless tunes live in concert this year. Make sure you get Umphrey's McGee tickets in time and reserve good seats for your loved ones. The band will be visiting Atlanta, Saint Petersburg, Orlando, Saint Louis, Kansas City and many more cities. Over the years, the band has given its fans eight studio albums, including Safety In Numbers, Mantis, Death by Stereo, The Bottom Half and the very recent, Similar Skin. Do visit the arena near you to enjoy the rocking tunes live on stage.
Umphrey S Mcgee Venues
- Umphrey S Mcgee Cains Ballroom
- Umphrey S Mcgee Hampton Beach Casino Ballroom
- Umphrey S Mcgee House Of Blues - Dallas
- Umphrey S Mcgee House Of Blues - Orlando
- Umphrey S Mcgee Jannus Live
- Umphrey S Mcgee Music Farm - Columbia
- Umphrey's McGee Orpheum Theater - New Orleans
- Umphrey's McGee Pier Six Concert Pavilion
- Umphrey S Mcgee Red Rocks Amphitheatre
- Umphrey's McGee Riverside Theatre - WI
- Umphrey's McGee St. Augustine Amphitheatre
- Umphrey S Mcgee Stubbs BBQ - Outdoor Stage
- Umphrey's McGee The Fillmore Miami Beach At Jackie Gleason Theater
- Umphrey's McGee The Norva
Umphrey S Mcgee Cities
- Umphrey S Mcgee Austin TX
- Umphrey S Mcgee Baltimore MD
- Umphrey S Mcgee Columbia SC
- Umphrey S Mcgee Dallas TX
- Umphrey S Mcgee Hampton NH
- Umphrey S Mcgee Miami Beach FL
- Umphrey S Mcgee Milwaukee WI
- Umphrey S Mcgee Morrison CO
- Umphrey S Mcgee New Orleans LA
- Umphrey S Mcgee Norfolk VA
- Umphrey S Mcgee Orlando FL
- Umphrey S Mcgee Saint Augustine FL
- Umphrey S Mcgee Saint Petersburg FL
- Umphrey S Mcgee Tulsa OK
Umphrey S Mcgee Schedule 2017-18
- Umphrey's McGee, Riverside Theatre - WI tickets for 03/30 08:00 PM at Riverside Theatre WI, Milwaukee, WI
- Thu Mar 30 2017
- Umphrey's McGee, Riverside Theatre - WI tickets for 03/31 09:15 PM at Riverside Theatre WI, Milwaukee, WI
- Fri Mar 31 2017
- Umphrey's McGee, Riverside Theatre - WI tickets for 04/01 09:15 PM at Riverside Theatre WI, Milwaukee, WI
- Sat Apr 01 2017
- Umphrey's McGee, Cains Ballroom tickets for 04/19 08:00 PM at Cains Ballroom, Tulsa, OK
- Wed Apr 19 2017
- Umphrey's McGee, Stubbs BBQ - Outdoor Stage tickets for 04/20 06:30 PM at Stubbs BBQ Outdoor Stage, Austin, TX
- Thu Apr 20 2017
- Umphrey's McGee, Orpheum Theater - New Orleans tickets for 04/21 08:00 PM at Orpheum Theater New Orleans, New Orleans, LA
- Fri Apr 21 2017
- Umphrey's McGee, House Of Blues - Dallas tickets for 04/22 09:00 PM at House Of Blues Dallas, Dallas, TX
- Sat Apr 22 2017
- Umphrey's McGee, Jannus Live tickets for 04/26 06:30 PM at Jannus Live, Saint Petersburg, FL
- Wed Apr 26 2017
- Umphrey's McGee, House Of Blues - Orlando tickets for 04/27 08:00 PM at House Of Blues Orlando, Orlando, FL
- Thu Apr 27 2017
- Umphrey's McGee, St. Augustine Amphitheatre tickets for 04/29 06:00 PM at St. Augustine Amphitheatre, Saint Augustine, FL
- Sat Apr 29 2017
- Umphrey's McGee, Pier Six Concert Pavilion tickets for 05/19 06:30 PM at Pier Six Concert Pavilion, Baltimore, MD
- Fri May 19 2017
- Umphrey's McGee, Hampton Beach Casino Ballroom tickets for 05/20 09:00 PM at Hampton Beach Casino Ballroom, Hampton, NH
- Sat May 20 2017
Umphrey's McGee has been performing more than hundred concerts every year, for about sixteen years. The rock band has been doing an amazing job; their sales numbers testify to it. They have sold more than three million tracks online. After giving their fans seven glorious studio albums, the band is still determined to provide them with more. Their eighth studio album, Similar Skin, was released in June 2014. They make music not just to entertain their loyal fans but also for those who never heard of them before. Enthusiastic rock lovers will be following the band to the Ravinia Pavilion, House of Blues, Orlando, Tower Theatre, PA, The Fillmore, Charlotte, and many more venues. This is a shout out to all the rock music fans to purchase Umphrey's McGee tickets and see for themselves how rocking this band is.
The American progressive rock group has its roots in South Bend, Indiana. Their musical compositions are often referred to as "progressive improvisation." The sextet comprises of Brendan Bayliss (guitar, vocals), Joel Cummins (keyboards, vocals), Ryan Stasik (bass guitar), Andy Farag (percussion), Jake Cinninger (guitar, vocals) and Kris Myers (drums, vocals). The band is musically influenced by renowned progressive rock artists such as Pink Floyd, King Crimson, Frank Zappa, as well as heavy metal groups including Guns N' Roses and Iron Maiden. Umphrey's McGee is also influenced by musicians Led Zeppelin, The Police and The Beatles.
The band was formed in 1997 at the University of Notre Dame when current members Brendan, Ryan, Joel and former member Mike Mirro (drummer) came together. At the time, the band started off by performing both cover songs as well as original compositions, live in concert. The cover songs included Vince Guaraldi's Peanuts theme Linus and Lucy, Guns N' Roses' Patience and numerous other songs by rock bands such as Moe, Phish and The Grateful Dead.
Umphrey's McGee released its debut album under the title Greatest Hits Vol. III. The album had popular numbers such as All in Time, FF, Divisions, Phil's Farm and more. Soon after the release of their debut album, Umphrey's McGee added percussionist Andy Farag as their fifth member.
In 1998, Umphrey's McGee as well as Ali Baba's Tahini were categorized amongst famous bands in the South Bend/Notre Dame region. Given the success of their music, Umphrey's McGee started to perform at colleges and house parties. They allowed the viewers to record their performances at will. The same year, the band introduced their debut live album under the title, Songs for Older Women.
In 2000, Umphrey's McGee added Jake Cinninger to the band, as the sixth member. Jake was former member of the band Ali Baba's Tahini. With this new addition, the band was flooded with a range of original musical compositions. Soon after Jake's arrival, the band introduced their second live album, One Fat Sucka. The album featured live performances of the band which were recorded in 2000.
Along the way, Umphrey's McGee has gifted their fans with a musical bouquet of eight studio albums, ten live albums, two extended plays and four video albums. They are soon coming to your town to entertain you. Umphrey's McGee tickets are selling now. Keep an eye out for their upcoming concert and reserve seats for your friends and family today.
Umphrey S Mcgee Events Tickets Prices
The average price for Umphrey S Mcgee Tickets start from $88. The minimum get in price is $31 for Umphrey S Mcgee Tickets at the The Fillmore Miami Beach At Jackie Gleason Theater, Miami Beach. For a detailed look at ticket prices and amazing discounts, visit our website.
Name | City | Date | Average Ticket Price | Get In Price (Minimum Price) |
Umphrey's McGee | Milwaukee | 30-Mar-17 | $156 | $52 |
Umphrey's McGee | Milwaukee | 31-Mar-17 | $178 | $55 |
Umphrey's McGee | Milwaukee | 1-Apr-17 | $169 | $39 |
Umphrey's McGee | Tulsa | 19-Apr-17 | $99 | $34 |
Umphrey's McGee | Austin | 20-Apr-17 | $135 | $43 |
Umphrey's McGee | New Orleans | 21-Apr-17 | $150 | $50 |
Umphrey's McGee | Dallas | 22-Apr-17 | $108 | $39 |
Umphrey's McGee | Saint Petersburg | 26-Apr-17 | $106 | $38 |
Umphrey's McGee | Orlando | 27-Apr-17 | $88 | $38 |
Umphrey's McGee | Miami Beach | 28-Apr-17 | $99 | $31 |
* Ticket Prices vary on hourly basis.


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Thrifty Meals For 2 Or 4 Or 6
The front cover has the title in a white box with a red line above a green plate of macaroni loaf with creole sauce and plate of vegetables. The back cover has an illustration of a baby's face above a promo for the Mary Lee Taylor radio program and a can of Pet Milk. Machine punched holes for insertion into Pet Recipes.
View this piece: jpg pdfDonor: Sliker, Shirley Brocker
Author: Taylor, Mary Lee
Brand Name: Pet Milk
Publisher: Pet Milk Co. (St. Louis, Mo.)
1945 (ca.)
15 p.
21 x 15.9 cm
Language: English
Key Terms:
Copyright: Permission is granted from the copyright owner/holder.
Citation: Taylor, Mary Lee. Thrifty Meals For 2 Or 4 Or 6. The Alan and Shirley Brocker Sliker Collection, MSS 314, Special Collections, Michigan State University Libraries. Available at http://www.lib.msu.edu/exhibits/sliker/detail.jsp?id=2513


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Croft Castle Half Term Holidays
Half Term holidays in Croft Castle
There is always plenty to do at half term in Croft Castle, Mortimer Country. Stay at one of Croft Castle Mortimer Country's historic farmhouses & B&B's and join in the fun
Halloween, Bonfire night, Half term in October/November
Celebrate autumn in Croft Castle with lots of local events; ghost tours at Croft Castle, Halloween crafts and cider making all over the area. And grand firework displays at Berrington Hall and Ludlow. Take an autumn walking holiday in Croft Castle with Wheely Wonderful Cycling along the mortimer Trail. Or take advantage of the last few rays of Autumn sunshine in Croft Castleand encourage your children and teens out into the fresh air.
Oaker Wood Leisure near Leominster have some great Multi- Activity Days for 7-12 year olds Activities will include a range from Climbing, Zip Wires, Halloween Hide and Seek, Fire Building, Target Shooting together with some special Halloween Woodland activities.
St Valentines and February half term
Stay at a romantic B&B, and eat a special meal at one of Croft Castle restaurants or inns who specialise in Valentines eve dinners. Or chose a tandem cycllng holiday from Wheely Wonderful Cycling, with an overnight stop at a Michelin starred country inn. Or follow the visit the romantic ruins of some of our amazing castles - Wigmore Castle and Hopton Castle.
Fancy an Adventurous February Half Term? Get together a group of at least 8 people and book Oaker Wood's Glamping Village Exclusively for your Group. 2 nights Glamping and 2 activities costs £140 per person.
Family reunion, or get together with several families - why not try a half term with a difference? Our Glamping village has 9 wooden pods with lighting and heaters, each sleeping between 4 and 8 people on bunk beds.
May half term
Celebrate the start of summer with a stay in Croft Castle, Mortimer Country. Cycling holidays from Wheely Wonderful Cycling, Mortimer Country are in full swing - or hire a bike for a day to explore the Teme Valley. Great value breaks from Croft Castle self catering holiday cottages - and close enough to be able to get to the prestigious Hay Literary Festival for the day. May,is also the best time to visit Croft Castle's wonderful gardens. From the Himalayan gardens of Hergest Croft, to Westonbury water gardens at Pembridge and the Arts and Crafts Bryan's Garden at Kinsham.
Details of gardens, activities and events in Croft Castle can be found on our website www.exploremortimercountry.com


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Lighting Designer Rob Sinclair used fifty square metres of Chroma-Q™ Color Web as a low resolution video wall backdrop on The Human League's Synth City UK Tour 2005 in December. The three-week tour featured a career-spanning set of the influential electro-pop group's greatest hits, backed by a cutting-edge lighting and video show designed by Sinclair and supplied by Lite Alternative. Sinclair had always been intrigued by the group's pioneering use of slideshow visuals during their early ...
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Senate Session
The Senate was expected to vote on a number of disapproval resolutions, including one to overturn a Labor Department rule exempting local-administrated retirement plans for certain…
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The House debated H.R. 1431, the EPA Science Advisory Board Reform Act.
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Representative John Delaney on Infrastructure Spending and Tax Reform
Representative John Delaney (D-MD) talked about legislation he introduced that ties tax reform to spending on infrastructure projects.
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Director Comey Remarks at Intelligence and National Security Alliance Dinner
FBI Director James Comey spoke at a dinner held in his honor by the Intelligence and National Security Alliance. He outlined the FBI's strategy priorities and the ongoing tension between…
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Tom Scully on Medicaid Expansion
Tom Scully, former administrator of the Centers for Medicare and Medicaid Services, talked about the decision by some states to expand Medicaid following Republicans' previous week's failed…
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Telephone lines were open for viewer calls and social media comments on the question, "What's the best way to combat the opioid crisis?"
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Telephone lines were open for viewer calls and social media comments on news of the day.
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First lady Melania Trump spoke at the State Department's 2017 International Women of Courage awards ceremony.
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Declared a Natural Monument in 1993, the hill of Acquafredda, topped by the ruins of a medieval castle rises imposingly on the Cixerri Valley, in an area with varied animal and plant life and sweeping vistas. Tradition has it that the eerie Acquafredda Castle was built by the Gherardesca Counts, specifically by the infamous Ugolino, one of the damned souls in Dante's "Inferno". However, given the lack of clear documentary evidence, experts give the date of the castle at about the first half of the 13th century. Climbing up the hills, we encounter three levels of ruins in order: the village, the cistern tower and the actual castle. The village, set below the castle, comprised the servants' and soldiers' dwellings, stables and stores. The village was defended by a crenellated curtain wall, about some 80 m long, of which scant traces: the ruins of four towers and of the chemin de ronde. The village also had a cistern, built of bricks and with a barrel vault ceiling. Further up along the slope, at the second level, we come to the ruins of a cistern tower, also with barrel vault roof and divided into three separate tanks which could be completely filled with water.
To reach the Castle of Acquafredda, take SS 130 for 35 km. At the sign for Siliqua take SS 293. After 4 km you will reach the foot of the Acquafredda hill. A footpath up the hill will take you to the ruins of the castle.
Phone: +39 3491564023 - +39 3497428014
Website: www.castellodiacquafredda.it
e-mail: firstname.lastname@example.com


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Plants Delivery South Africa
Order Plant Gifts Delivery Online in South Africa
Plant are great way to show your lasting love and care. If your recipient likes gardening or loves plants and flowers, ordering plant for gift and having it delivered will make lasting impression.
In any case, in the event that you need to express your inherent feelings, you can make plants delivery, one of a through a flower plant delivery administration. It might be straightforward yet sending these wonderful gifts would help their hearts in an extremely exceptional manner. Plants improve the world. They advance and enhance our encompassing inside and out. It additionally helps individuals feel healthier and more satisfied when they are encompassed with plants and flowers. Along these lines, the vast majority utilization plants as a representation of distinctive emotions they need to pass on to their loved ones and companions the feelings they may not express through words. So, you can send plants as a part of the gift.
A standout amongst the most sublime plant gifts are Jade Bonsai potted tree or Dwarf Pyracantha Bonsai Tree with orange to red shading berries. For that you can buy plants online. In the event that you love somebody then passionate purple Phalaenopsis orchid plant will be the simply right gift to express your internal feeling. The Japanese Five Needle Pine is viewed as The Prince of Pines for bonsai utilization and this tree can be the ideal gift for the plant lovers. Bloom plants conveyance turns into a well known method for sending your passionate message to your companions, families and loved ones. There is a colossal mixture of plants online. All you have to do is to order plants online for delivery.
Searching Best Plants for Mothers day in South Africa? From Azalea Bonsai to Lucky Bamboos, shop Giftblooms for the freshest Plants delivered.


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2011-12-28, 14:08 | Link #24 |
The Comet has Come
Join Date: Feb 2008
Location: Republic of California
Age: 39
They remind me of some charcters from one of KyoAni's commercials
2012-01-08, 23:13 | Link #27 | |
Critical fanboy
Join Date: Oct 2011
Location: Anywhere with anime and anime discussion is fine
2012-01-08, 23:48 | Link #28 |
The Comet has Come
Join Date: Feb 2008
Location: Republic of California
Age: 39
That, in its own way, makes him "Kyon". A boy who was into all sort of strange thing before high school, but gave them up when he got there...only to have his real life shattered by a girl that still believed...and at least one other girl....
The only think we don't know is his personality at present. He doesn't look cynical and snarky in the promotional image. So this is a wait and see or read it if you can find it and give us a clue.
2012-01-20, 16:18 | Link #31 |
The Comet has Come
Join Date: Feb 2008
Location: Republic of California
Age: 39
That is possible too. Though still the thought remains as to when, though if it is an OVA they aren't as tied to seasons.
And two novels can be made into a 12 or so episode series. If there is enough plot per novel to sustain 6 episodes each.
2012-01-20, 16:27 | Link #32 |
I think it's highly unlikely we'll see it in the summer. If there is something released on TV, it'd likely be a Fall 2012 series. The only series you could say KyoAni released during the summer only would be the new episodes during Haruhi's re-airing. By then a third novel will have likely come out, giving 4 episodes per novel for a 12 episode season and a decent adaptation rate. Of course, they could go for a movie to continue the trend of TV series/movie in the 2010s.
2012-02-09, 14:14 | Link #37 |
Prefectural Magical Girl
Join Date: Apr 2010
Location: Paris, France
It's possible for this title to be aired on the same season as Hyou-Ka, due to the fact that KyoAni did the same trend in April 2009 with the second Haruhi Suzumiya series (not really the new series, but the last 14 episodes shown in July are new episodes compared to the old first 14 episodes which were originally released in 2006) and K-ON!.
Tags |
chuunibyou, drama, kyoto animation, romance, romantic comedy, school, seinen |
Thread Tools | |


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I-TAC is a unique, fully equipped space for innovation, research and development, providing flexible access to laboratory space, "hot-labs" and scientific equipment. It is ideally suited to start-up companies, small and medium enterprises (SMEs) and R&D teams from established companies.
Companies using I-TAC are working in diverse sectors: from medical biosciences and energy and the environment, to down-stream space technologies and advanced materials and the chemical sector.
Locating to I-TAC accelerates innovation and boosts business growth. Founded at Sci-Tech Daresbury in 2010 and extended to Harwell Campus two years later, this multiple award-winning STFC facility has already supported around 60 start-ups, SMEs and R&D teams from established companies, delivering easy access to:
Now incorporating specialist I-TAC units in micro and nanotechnology at Harwell Campus and biotechnology at Sci-Tech Daresbury, I-TAC's flexible support framework has been harnessed by all kinds of businesses to create inspiring success stories. For example:
To find out more about I-TAC:
Michael Norris
Business Incubation
+44 (0)1925 603114