text: Bill Gates Just Took Over Late Night With Silly CostumesGergo Vas1/22/14 8:00amFiled to: watch thisbill gatesmicrosoftthe internetfunnyhumorjimmy fallonlate nighttv8710EditPromoteShare to KinjaToggle Conversation toolsGo to permalinkGIF It's seems like Bill Gates is still in shape and his sense of humor is the same as 20 years ago. He was Jimmy Fallon's guest last night, promoting his website, GatesLetter.com with the help of this little clip.AdvertisementHere's the complete segment:Did they remove Fallon's Macbook during Gates' visit? Don't worry, it was on his desk throughout the whole interview:GIF Here's the follow-up, where Gates talks about how interacting with computers will change in the future.Bill Gates' Viral Video: GatesLetter.com [YouTube]AdvertisementTo contact the author of this post, write to: firstname.lastname@example.com repliesLeave a reply


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Oticin Ear Drops Dosage
Generic name: CHLOROXYLENOL 0.01g in 10mL, PRAMOXINE HYDROCHLORIDE 0.1g in 10mL
Dosage form: ear drops
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
The external ear that is the auricle and the auditory canal should be thoroughly cleansed and dried. Four (4) to five (5) drops of Oticin Ear Drops should be instilled into the affected ear 3 to 4 times daily. For infants and small children, 3 drops are suggested because of the smaller capacity of the ear canal. The patient should lie with the affected ear upward to instill the drops and this position maintained for at least 5 minutes to facilitate penetration of the drops into the ear canal. Repeat, if necessary for the opposite affected ear. If preferred, a gauze ear plug or wick may be inserted into the ear canal prior to applying Oticin Ear Drops. When using a wick, a few drops of sterile water should be applied directly to the wick following insertion to facilitate hydration. It should then be saturated with Oticin Ear Drops. The patient should be instructed to add a few drops of Oticin Ear Drops to the wick every four hours, and to remove the wick after 24 hours. Five (5) drops of Oticin Ear Drops should continue to be instilled 3 or 4 times daily thereafter. When using a gauze earplug, the external ear canal is first treated with drops of Oticin Ear Drops. Next, the gauze is inserted into the ear canal to contain medication. The gauze ear plug or the expanded wick are easily removed by fingers, forceps, or tweezers. This product may continue to be used in the unaffected ear 3 times daily as a preventative.
More about Oticin (chloroxylenol / pramoxine otic)
- Side Effects
- During Pregnancy
- Dosage Information
- Support Group
- 0 Reviews – Add your own review/rating
- Drug class: otic anesthetics
Consumer resources
Other brands: Pramotic, Uni-Otic

subset: commoncrawl


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Increase Revenue
Reduce carbon emissions
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Capture Vapors at no extra expense
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Single Compressor for reduced rental costs
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FLOGISTIX has developed a new line of wellhead compressors, the FX series, designed to meet all wellhead compression and vapor recovery applications. Our industry leading control panel, the LOGIX PLC, monitors all compressor functions giving our customers total control and increased production. All units include satellite telemetry and are available on our unique 30 day rental contracts. FLOGISTIX offers no charge well analysis with economic justification in our Petroleum Engineering Department for our valued customers.


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Naomi Kokubo is the indie developer of Beetle Bounce, an October App of the Week winner. Brand new to mobile development, Naomi used Corona SDK to build her first game. From writing all the code, to creating all the animation, Naomi writes on her "do it yourself" approach to building a game she's proud of.
I believe you can't build a truly great game unless you iterate like mad, and there's no better way to iterate than to code it yourself.
A little over a year ago, I had no real programming experience. I did have ample business experience. I was the COO of two venture-funded startups and had worked in the gaming business for years.
So I was faced with a choice: I could hire an engineer, artist, designer and composer (as I'd always done), but this gets expensive fast! Or I could try to make a game entirely on my own. I really wanted to develop my own, personal games without being dependent on anyone else for funding, design and implementation. I'm also a mother with two kids, and I wanted the flexibility of working from home. Everything considered, I chose to go it alone.
With virtually no coding background, I began looking around for the best solution that would allow me to get up and running quickly, but wouldn't limit my game in the long run.
- Game Salad looked simple enough, but it was too limiting.
- Unity 3D seemed nice for 3D games, but creating a 2D game seemed like a lot of work with a high learning curve.
- HTML 5 was sexy but had lots of issues. In my opinion, it just wasn't ready for games.
After analyzing all of the software packages on the market, I decided on Corona SDK because it felt like the right blend of functionality and flexibility. It also cross-compiled to iOS and Android, a huge plus for an indie developer.
Now, here's how ignorant I was. I didn't even know what an API was. I used to blank out when anyone talked tech to me. When I started with Corona, I literally had to look up on Wikipedia what an API was.
Less than 6 months later, I'd completed my first game, and I not only coded it, but I also did 100% of the art, animation, UI design, game design and every other task. It was a fantastic experience, and the one thing that made it possible was the support of my peers in the Corona community. Without their support, I couldn't have done it.
My game, Beetle Bounce (www.lavamind.com) went on to receive lots of great reviews, was a Featured App on the Kindle Fire, and was a Top Game Pick on the NOOK! I was thrilled.
I'm now working on my second game, which is more ambitious than the first. I recently learned MySQL and PHP and set up a database with multiplayer asynchronous gameplay. Amazingly, it works! The game is nearly done and will launch by Christmas.
I have to say that I love what I do. I plan to keep going solo for the time being. It's so rewarding that even the pain of having to do it all yourself pays off in a million little ways. And I want to thank everyone in the Corona community who has been so kind to help me get this far!
Naomi Kokubo
Co-founder of LavaMind
NOTE: If you're interested in trying out Beetle Bounce, you can download it from these sites:
iTunes: www.itunes.apple.com/app/id471409331?mt=8
Kindle: www.amazon.com/gp/product/B008O9LP4O/ref=mas_pm_beetle_bounce
NOOK: www.barnesandnoble.com/w/beetle-bounce-lavamind-llc/1111944291?ean=2940043909749
Google Play: www.play.google.com/store/apps/details?id=com.lavamind.beetlebounce


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quick question:
Are you 21
or over?
or over?
Tangy, sweet and just a little hot, this is the best red pepper jelly we've certainly come across. Bonnie was inspired by a version she tried in Alabama, but her recipe for this Southern staple took longer than expected (she was used to working with fruit!). Almost immediately it became one of her most popular flavors.
Try Bonnie's tip for Red Pepper Jelly Guacamole: In a small bowl, mash 4 very ripe avocadoes until smooth. Add 1/2 cup jelly and 2 tablespoons chopped white onion. Mix well and serve with crispy torilla chips. Boom!
We also love it on a cheddar cheese or smoked turkey sandwich with Tin Mustard.


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Travelodge Boston hotels are listed below. Search for cheap and discount Travelodge hotel rates in Boston, VA for your upcoming individual or group travel. We list the best Travelodge Boston hotels so you can review the Boston Travelodge hotel list below to find the perfect place.
This site will provide Boston, VA hotels/lodging that are comparable to the quality of Travelodge.Booking a group or meeting? Set up a group hotel block in Boston VA
How should we direct your call?


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« How Logic Can Help Save a College Student's Faith | Main | How Conveeeenient! The Church Lady Tactic »
Hello. My mind has been extremely busy and eager to learn more about the evidence for Christianity.
As long as I read stuff from Evangelical apologists like McDowell, I thought that the truth of Christianity was obvious, that it stood to reason I had the truth.
But then I began reading also books from atheistic apologists and realized things are far from being easy.
Now I realize that both Christian and godless apologists can be extremely biased and I've become an agnostic.
But emotionally, my heart longs for the God revealed through Jesus of Nazareth, that's why I make the choice to hope on him, in the absence of convincing arguments against the truth of Christianity.
My blog is all about my honest reflections on many topics related to faith, science, doubts and the New Atheism.
I hope to bring a balanced view in very polarized discussions.
Lovely greetings from Europe.
Lothars Sohn – Lothar's son
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Always be prepared to give an answer to everyone who asks you to give the reason for the hope that you have. But do this with gentleness and respect. |
I urge you to contend for the faith that was once for all entrusted to the saints. Jude 3 |
For though we live in the world, we do not wage war as the world does. The weapons we fight with are not the weapons of the world. On the contrary, they have divine power to demolish strongholds. We demolish arguments and every pretension that sets itself up against the knowledge of God, and we take captive every thought to make it obedient to Christ. 2 Corinthians 10:3-5 |
For we did not follow cleverly contrived myths when we made known to you the power and coming of our Lord Jesus Christ; instead, we were eyewitnesses of His majesty. 2 Peter 1:16 |


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Land Registry: Property Portfolio Consolidator
- From:
- Land Registry
- Part of:
- Land Registry commercial services and Business and mortgage services
- First published:
- 8 June 2016
- Applies to:
- England and Wales
Consolidate, strengthen and update the information you hold on your properties and identify vulnerable titles you can secure.
Our Property Portfolio Consolidator gives you an overview of all registered property in England and Wales, held in the name of your company (or any previous names under which it may have been known).
The report provides the title number, property address, tenure, ownership information and charge information.
The following extra information can be provided on request to enhance your data:
- an ownership layer showing all mapped titles for a geographical information system (GIS)
- title plans for every registered property you own
- lease details
- current and historical price paid information for individual titles going as far back as 1995, where available
You can choose to keep your portfolio up to date with reports that show:
- titles added to your stock
- titles removed
- titles where further activity has taken place of which you should be aware
If you are looking for extra levels of monitoring, please see our Searchlight service.
Property Address Confirmation service
If you are only looking for property address information and have either carried out a search of the Index of Proprietors' Names (IOPN) or have a list of title numbers, there is an option to buy our Property Address Confirmation service. This service will provide address details only.
Property Portfolio Consolidator
Each property analysed in your report costs £4.25 (£1.25 plus £3 for the official copy of the register).
The total price depends on:
- how many titles appear in your results
- how many extra features you would like
- whether you would like to keep your portfolio up to date with our monitoring service
Property Address Confirmation
Costs are based on the amount of addresses you want to check (with a minimum charge of £60). There is also a £50 extraction fee. All prices do not include VAT.
number of titles | cost |
up to 2000 | £1 per title |
2,001 to 20,000 | 35p per title |
20,001 to 200,000 | 20p per title |
200,001 to 500,000 | 17p per title |
500,001 and above | 7p per title |
More information
To find out more about this service, please contact us.
Business Development Fulfilment Team
Contact form https://landregistry.c...
Phone 0300 006 0478
Document information
Published: 8 June 2016


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Potential Options to Reduce ESA Liability for Private New Mexico Irrigators Who May Be Liable for a Section 9 'Take'
Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/10486
View/ Open
Potential Options to Reduce ESA Liability for Private New Mexico Irrigators Who May Be Liable for a Section 9 'Take'
Klise, Geoffrey T.
Customary irrigation techniques employed by New Mexico irrigators may place them in jeopardy of a Section 9 'take' under the Endangered Species Act (ESA) if their diversion constitutes a foreseeable harm that may kill or impair reproduction of a listed fish species. Unless irrigators are covered by a federal incidental take statement, anyone can challenge the activity if harm was done or may occur in the future. What constitutes a 'take' is a highly contentious issue; a dead fish is not necessary to prove an action will violate Section 9 since future 'harm' that is 'imminent' can also be seen as a 'take.' How may irrigators reduce their liability in a situation where the diversion clearly poses harm? The option with immediate benefits for fish is for an irrigator to leave more water in-stream by increasing irrigation efficiency. This must be backed up by applying for a Section 10 Habitat Conservation Plan (HCP) or Safe Harbor Agreement to gain legal protection from a lawsuit.
New Mexico has not developed in-stream flow incentives for irrigators because historically, state law has not explicitly recognized the value of water left in-stream for fish. This complicates the situation for New Mexico irrigators not tied to federal programs, which includes many small community irrigation districts and acequia communities. New Mexico irrigators should be pro-active in protecting their water right. Emerging state-based incentive programs that seek to leave water in-stream are a start in the right direction, but applied alone without a Section 10 HCP, will not fully reduce their ESA liability.
Publication (University of New Mexico. Water Resources Program) ; no. WRP-14
This publication is the Professional Project report of Geoffrey T. Klise, submitted in partial fulfillment of the requirements for the Master of Water Resources degree at the University of New Mexico (August 2005).
Endangered Species Act (ESA)
Rio Grande silvery minnow
Southwestern willow flycatcher
Habitat Conservation Plan (HCP)
The 'harm' regulation
Section 9 Injunctions
Rio Grande silvery minnow
Southwestern willow flycatcher
Habitat Conservation Plan (HCP)
The 'harm' regulation
Section 9 Injunctions


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& 07718 763273
Please quote 'The AA'.
Website: http://www.rivergarth.co.uk
Credit cards not accepted
M6 junct 40, A66 E towards Scotch Corner. At rdbt 4th exit to Shap, 150yds over bridge & continue for 200yds, turn right at "Keep Clear" road marking. Last bungalow facing river with balconies
Nearest station: Penrith
Nearest motorway: M6 junct 40


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Author Kristin Downey on the labor rights activist Frances Perkins, who would go on to become the secretary of labor and the first woman in a U.S. Cabinet.
Chapter 1: Family
Frances Perkins was born in 1880. And that's when we see a very large surge of immigration to the United States. The U.S. population is changing very dramatically. A lot of companies are doing a lot to recruit immigrants, particularly from Europe to the United States and, and in many cases paying them very poorly when they arrive and having the workers work in very poor conditions. What this means is that you see a very great and growing gap in wealth between the rich and the poor. And for people like Frances Perkins and her family, who are great believers in equalitarian democracy, this is a troubling trend. They see that you can have an underclass that is not treated as well and an overclass that can become very wealthy at the expense of the others.
Chapter 2: Education
Frances Perkins' family was conventional but they did something with Frances that was quite unconventional for the day. At that time only three percent of American women went to college. Frances Perkins' family sent her to college. They sent her to Mt. Holyoke, which was a woman's small, private woman's college close to their home in Worcester.
It was believed that an educated woman would be a less desirable marriage partner for men. And at that time, marriage was the end goal of most families for their daughters. So this was quite an unusual thing to send Frances off to college. What she chose to study was also unusual. She majored in physics and chemistry at Mt. Holyoke. She took the heaviest courses.
Chapter 3: New York
She goes to live alone in New York City at this period, and she actually goes into the area that's the most avant-garde place in the United States, arguably one of the most avant-garde places in the world. She settles in Greenwich Village. And at that time there was an enormous ferment and excitement in Greenwich Village. There were immigrants pouring in from all over the world; there were political radicals; there were free thinkers; there were birth control advocates; there were communists; there were socialists; there were ideologues of all kinds; there were aspiring writers; there were people that hoped to use the political system to change the world. It was a very heady cocktail of life that she had in Greenwich Village. And she loved it. She partook of it and she learned an incredible amount during those years.
Everything about her life at this time is unprecedented in the American experience. She's living alone. You know first she's in a settlement house with other women. Then she gets an apartment and she's living alone in New York City at a time it was very unusual for women alone. She's changed her name. She had been born with the name Fannie. She's renamed herself Frances. She's traveling with a lot more radical and socially adventurous crowd in New York City. At this time, let's put this all in context, women don't have the right to vote. They're not allowed to appear very much in public. They can't go to a hotel. It's considered improper for them to eat alone in a restaurant. They can't travel anywhere unaccompanied with a man they're not married to. These are all things that are extremely limiting to women who have big dreams for themselves. And Frances Perkins sets out to flout every one of those conventions.
Well we see Frances Perkins very interested in social causes from a young age. But she's still quite young at this time, you know. She's in her late 20s, just about 30. She's learning that the problems are much more are much more difficult to solve than she'd early hoped. Like many idealists, she originally hoped that people who saw a problem, who once informed of the problem, would be quick to find a solution. What she found is it's much more difficult to make social change than that. And she began to realize that she would need to be a lot more proactive.
Chapter 4: Labor Conditions
In 1910 Frances Perkins ended up landing a job with the woman who had so impressed her, Florence Kelly, when she'd been a student at Mt. Holyoke. She goes to work at the National Consumers League which is an organization devoted to fighting child labor and bad working conditions. She begins immediately to do research and investigate New York's factory conditions where her particular interest is fire safety and fire hazards in factories and in retail stores. And she begins to gather information immediately.
As competition grew greater in the American workplace, as companies sought to prosper by shaving costs they began to ask workers to work longer and longer hours often for lower and lower wages. And more and more children came to be employed in places that we would now consider an industrial setting. In fact it was there that Frances Perkins first saw children working in factory settings. And this was very shocking to her. Children working long hours; children younger than herself working long hours and frequently suffering injuries on the job.
At that time there were no limitations on how many hours workers could be asked to work and there was no standard, workplace standard. It was very common for workers to be asked to work 12 hours a day. There were times that some workers worked as many as a hundred hours in a week at that time. Frequently they worked on Saturday and even on Sunday. What Frances Perkins and the people at the National Consumers League came to believe was that this was very dangerous for the health of the workers and terrible for their families who would -- often children would be left untended for hours at a time while both the father and the mother worked. If there were any further problems in the family, the children would be put to work as well. You had children as young as seven and eight years old working 12 and 14 hours a day in various factories. This was very disturbing to Frances Perkins but it was also very difficult to legislate a change.
Frances Perkins and her allies at the National Consumers League were trying to get a 50-hour-a-week limit imposed on women's employment so women would not have to work more than 54 hours a week because so many studies had shown it was very hard on their health and on the health of their children if they worked more hours than that.
Chapter 5: The Triangle Factory Fire
It was a lovely spring day. And Frances Perkins set out for what she'd imagined would be a lovely afternoon with her good friend Margaret Morgan Norry who had a home facing Washington Square in New York City. She went to join her for tea. And the two women were just sitting down when they heard a commotion on the street. The butler came in and said he'd heard there was a fire. And the women jumped up from their seats and raced across the park. Frances Perkins arrived at the base of the building just as the first women begin jumping to their deaths.
It was a horrifying moment. She had studied workplace conditions, particular fire hazards. But this is the first time she sees in front of herself the real terror and horror that is occurring in these workplaces where there are no fire safety measures. She sees more than a hundred people die that day. She's horrified by it. She's shocked. She's appalled. She's galvanized. She begins to believe that she's got to change this, make it stop and she begins to try to mobilize every tool that she has to make that happen.
People who knew her said that she was forever changed by that sight; that she was never the same carefree, young woman that she had previously been living in Greenwich Village. She felt an enormous sense of social obligation to solve the problem. She had known that workplace conditions were very bad. She was beginning to realize how difficult it was to lobby for regulations to change those conditions. She felt it was her duty to try to fix it.
Chapter 6: Legislation
Frances Perkins is already doing work along these lines so it was only natural that she would be a logical candidate to play a lead role in trying to crack the legislative remedies that activists thought were needed. And in fact she was already becoming so well known that it was Teddy Roosevelt who specifically suggested her to be to be a leader of the committee on safety. Frances took on the job. She went to Albany. And now instead of just representing the National Consumers League, she's part of a group called the Committee on Safety.
She took a lead role as investigator for this Committee and she began to arrange hundreds of hearings all over the state of New York. Thousands of people testified about workplace conditions all over the state. And people began to raise concerns about what they were seeing unfold in work places all over. Now it wasn't just workers or activists testifying, these were employers, foremen, bankers, insurance men, all the people involved in the economic system all came and testified about the conditions that they were seeing in their workplace. And together they began to craft legislative solutions. Now almost immediately this resulted in legislation. Very quickly fire drills became mandatory; fire exits began to be marked; fire water sprinkler systems began to be installed in new factories. And this these were all things that could save many lives. Occupancy limits were established for buildings. Now remember this is a key issue because one of the things that happened in the Triangle fire is it was so overcrowded that people couldn't safely get out of the exits. These were all things that come out of legislation that Frances Perkins helps to craft and helps to draft.
Frances Perkins engineered this entire series of hearings. They appear in a 13 volume series of books with hundreds of people testifying all over the state. Her fingerprints are everywhere. Her name appears almost nowhere. But to the people who knew what was happening, to the people who were participating in this, they knew what a primary role she was playing. Al Smith called her the chief investigator but opponents called her the most prominent agitator.
Chapter 7: Legacy
The Triangle fire and its aftermath marks a major turning point in Frances Perkins' life. Until then she'd been really uncertain what course she was gonna take in her life and really somewhat undecided about how aggressive she was gonna be in pursuit of her career. But after the Triangle fire she is a very well known person in New York City. By the time she's 33 years old -- and remember she still does not have the right to vote -- she had drafted and enacted dozens of pieces of legislation in the state. She has addressed the National Fire Prevention Association meeting as their keynote speaker. Her workplace and fire safety reforms are being promoted all over the country. She has become a famous person in her own right. She's a person who's known and it's only reasonable to expect that she will be a person who will go on to a more important position in industrial relations in the coming years in New York State and in the country.
The Triangle fire haunted Frances Perkins for the rest of her life. When she joined Franklin Roosevelt as his Secretary of Labor in 1933 when he was elected president. Workplace safety was one of the key issues that she brought to his attention. She'd held a series of state conferences where she pushed state officials all over the country to enact the same kind of workplace regulation that they had enacted in New York. That's why anywhere that you go in the United States now you will see signs on occupancy limits, people will come and remove the flammable trash from the office, you will experience fire drills, you will know where the fire exits are. These are all landmark actions taken by the State of New York and it spread everywhere thanks to Frances Perkins' stewardship in 1913 and for the next 60 years.
Well Frances Perkins is a questioning person and she's an empathetic person. She looks at the world around her with great interest all her life and asks questions about why is it, what can explain the gap between rich and the poor? Why are some people rich and why are some people poor? And is there anything that can be done to improve the situation? She describes it as vicarious physical agony that she feels when she contemplates the very poor living conditions that are emerging in the United States and as she deals with, as she begins to think about how that can be remedied.
It was the deadliest workplace accident in New York City's history. A dropped match on the 8th floor of the Triangle Shirtwaist Factory sparked a fire that killed over a hundred innocent people trapped inside. The private industry of the American factory would never be the same.
His stunning triumph at the 1936 Olympic Games captivated the world even as it infuriated the Nazis. Premiering May 1.
The influential musical pioneers from Appalachia whose recordings lifted spirits during the Great Depression.
John Scopes' free speech trial pitted science against religion after the teacher presented Charles Darwin's theory of evolution in a Tennessee school.
Though first seen only as an expensive luxury, Alexander Graham Bell's telephone soon transformed American life and became a necessity.
The shocking story of Richard Leopold and Nathan Loeb, two wealthy college students who murdered a 14-year-old boy in 1924.
The most daring and innovative accomplishment at the turn of the 20th century.
Roman Catholic priest Father Charles Coughlin used the power of radio to rail against the nation's economic system in the Depression.
A uniquely impressionistic history of the early years of the Space Race.


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text: Originally introduced in 1975, the Destroyer became an icon of that era. The Ibanez DT520 Destroyer Electric Guitar is the latest incarnation and provides classic looks, tone and feel. The body and neck is made of a tight Mahogany for maximum resonance. Ibanez gives the DT520 Destroyer set-in neck construction for optimal sustain, DiMarzio Air Norton and DiMarzio The Tone Zone humbuckers and Sure Grip III control knobs for no-slip control.


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Guitar Preamplifier
Voodoo Lab Giggity
$129.99The Voodoo Lab Giggity is a versatile sonic tool that can make dramtatic changes to the overall tonal character of any guitar. Give some single coils the heft and body of a Les Paul, or add some air to a stale sounding amplifier. Learn More


text: Old-School Final Fantasy Is Back With A New NameJason Schreier9/27/13 12:00pmFiled to: bravely defaultbravely default: flying fairy3dskotakucoresquare enix1642EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Here's the first English trailer for Bravely Default, an upcoming Square Enix role-playing game for 3DS that seems like old-school Final Fantasy in everything but name. I mean, just look at that intro. Four crystals! White mages! Sweet music! Note that this is a trailer for the UK version, but presumably the North American release won't be all that much different.Reply164 repliesLeave a reply


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Date | May 7, 2013 | Time | 7:00 - 8:30 am |
Location | Lawry's Prime Rib 14655 Dallas Pkwy Dallas, TX | ||
Description | The BBN Dallas features Terry Maness – Dean of the Hankamer School of Business, and Ken Hall – Senior Vice President for University Development & Strategic Initiatives at its next networking event. Dean Maness will inform the group on the progress of the new business school and the efforts being exerted to bring the new building to fruition. Dr. Hall will speak on new fund raising initiatives, ongoing capital projects, future capital projects, and the progress being made to achieve the goals and objectives set forth by Baylor. RegistrationPricing• Individual ($15*) Deadline05/06/2013 11:00 AM How to registerRegister online below or call 1.866.281.9444. Online registration is now closed. Please call 1.866.281.9444 to register. Thank you. | ||
Publisher | The Baylor Alumni Network | ||
vCal | Download this event |


text: Archive for March 3rd, 2014 View: News Blogs Programs News LA's rain will likely reduce fire risk later in the year March 3rd, 2014, 5:32pm | Sanden Totten Rain in Southern California likely won't cause more fire-prone grass to grow, researchers say. It may even help keep chaparral hydrated during the dry summer months. LADWP apologizes for billing problems, launches web page to track fixes Local | March 3rd, 2014, 5:25pm | Jed Kim The new page provides information on call volume and wait times. It also shows how much money the utility has left uncollected because of system problems. A colorful night at the Oscars. More of the same to come? Arts & Entertainment | March 3rd, 2014, 5:16pm | Eric Deggans | NPR Artists of color won in some of the most prestigious categories at Sunday's Academy Award ceremony. Is this a sign of change, or exceptions to the rule? Shutdown cost national parks at least $414M US & World | March 3rd, 2014, 4:24pm | Matthew Daly | AP National parks saw nearly 8 million fewer visitors due to the government shutdown, costing parks and surrounding areas millions of dollars, the Interior Department said. Ruling could mean more murderers paroled in California Local | March 3rd, 2014, 4:23pm | Rina Palta A federal judge recently struck down portions of two tough-on-crime ballot initiatives that hampered the ability of prisoners to be paroled. The decision could lead to the release of many serious felons. If he's sexually aggressive in bars, it's not because he's drunk US & World | March 3rd, 2014, 3:27pm | Maanvi Singh | NPR A study finds some men force unwanted sexual attention on women who have been drinking because they may be seen as more vulnerable. China arrests 3 suspects in Saturday's deadly knife attack US & World | March 3rd, 2014, 3:03pm | Bill Chappell | NPR All eight people responsible for the attack are now accounted for, the state-run Xinhua news agency says, citing a police report. Bill Gates back on top of Forbes' billionaire rankings March 3rd, 2014, 2:14pm | AP Forbes' Magazine announced its rankings of the world's billionaires Monday with Bill Gates reclaiming the top sport after four years. Dunk now, pay later: Elite college players may suffer in middle age Arts & Entertainment | March 3rd, 2014, 1:53pm | Nancy Shute | NPR Division I athletes may be at the top of their game in college, but researchers say they will often have more health problems than people who never played sports. 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Early baby deliveries plummet in US, California Health | March 3rd, 2014, 11:39am | KPCC Staff Hospitals responding to a private group's survey report significant drops in their rates of early deliveries between 2010 and 2013. With death penalty, how should states define mental disability? Health | March 3rd, 2014, 10:57am | Nina Totenberg | NPR In 2002, the Supreme Court banned the execution of the "mentally retarded." Monday the court is looking at the case of a convicted man who says Florida's definition of mental disability is too strict. E-cigarette critics worry new ads will make 'vaping' cool for kids Health | March 3rd, 2014, 10:41am | Debbie Elliott | NPR As electronic cigarette companies get bold with advertising, anti-smoking groups fear the ads will lure teens and get them hooked on nicotine. 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Using big data to predict the Oscars March 3rd, 2014, 9:07am | Take Two Big data cruncher David Rothschild correctly predicted 21 of the 24 Oscars categories...even though he'd only seen 2 nominated films. On the Lot: '12 Years a Slave', 'Gravity,' more March 3rd, 2014, 9:07am | Take Two Today: A visit to LA's Creole Corridor where true Mardi Gras traditions are alive and well. Plus, "Twelve Years a Slave" wins best picture and a part in public school curriculum around the country. The Loh Down On Science Episode: Do five eyes see better than two? How much better do five (compound) eyes see? March 3rd, 2014, 6:00am | The Loh Down On Science Just when you thought it was safe to go back in the water…. AirTalk Episode: AirTalk for March 3, 2014 Do hiring managers care where you went to college? March 3rd, 2014, 4:22pm | AirTalk A new survey from Gallup Education shows that only nine percent of business leaders consider the school an applicant attended to be "very important" when it comes to hiring decisions. Would an open-carry gun law be better than more concealed weapons in California? March 3rd, 2014, 11:05am | AirTalk Orange County Sheriff's Department has seen a huge influx of applications for concealed carry weapons (CCW) permits. Washington weighs response to Russia's invasion of Crimea March 3rd, 2014, 10:50am | AirTalk Washington is facing a tough foreign policy challenge now that Russia has escalated the conflict in Ukraine by seizing control of the country's strategic Crimean peninsula. Surprises, snubs and slam dunks: Who won big at the Oscars? March 3rd, 2014, 10:38am | AirTalk Hollywood's biggest night delivered plenty of glamor, eloquent speeches and the world's best selfie, thanks to host Ellen Degeneres. What's the cost of luring or losing film & TV production in LA? March 3rd, 2014, 10:29am | AirTalk For the past decade and a half, California has seen its position as the center of the global entertainment industry come under siege. Off-Ramp The friendship behind 'Madam Satan,' Cecil B. DeMille's musical disaster Arts & Entertainment | March 3rd, 2014, 3:08pm | Debra Levine | Off-Ramp Dance writer Debra Levine tells the untold story of the legendary director's only musical and one of his few flops. Browse our news archive January February March April May June July August September October November December 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017


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Gambling commission in Quebec will not allow bets on whether local becomes pope
MONTREAL — All bets are off in Quebec as to whether a local becomes the next pope.
The provincial lottery commission says it will not follow the lead of some foreign gambling houses that allow people to place bets on who might inherit St. Peter's throne.
The organization isn't swayed by the fact that a fellow Quebecer, Marc Cardinal Ouellet, just so happens to be the favourite or among the top picks according to bookmakers.
While Loto-Quebec recently branched out beyond sports gambling by introducing betting on the upcoming Oscars, a spokesman said Wednesday it has no plans to get into religion.
"Loto-Quebec has no intention to offer betting on the identity of the next pope," said spokesman Jean-Pierre Roy. "I don't think that's what people would expect from a government organization."
Roy said sports gambling has been a fixture since the early 1990s. In recent weeks, the corporation has been testing the waters on betting on the Oscars and Roy says it will only know after the Feb. 24 ceremony whether it was a hit. The Atlantic Lottery Corp. was the first to announce it would offer Oscar betting this year.
"But betting on a religious event, we're not sure that would be the best way to go," Roy said.
Since Pope Benedict XVI's surprise announcement on Monday that he will step down on Feb. 28, Quebecers have weighed in on whether Ouellet could be next in line.
Ouellet, the 68-year-old native of La Motte, Que., was named a cardinal in 2003. In 2010 he was made head of the powerful Congregation for Bishops, which vets bishops nominations worldwide.
"The fact that a Quebec cardinal is in the running of course increases the (interest) and people may be asking whether we'll offer it (betting) or not," Roy said. "But we've done our thinking here and we have no intention of offering betting on such an event."
While gambling isn't spelled out in the Bible as wrong, scholars note it goes against several principles of the faith itself.
Some foreign bookmakers have jumped into the fray, however, with Irish-based Paddy Power installing him as favourite at 7-2.
A spokesman for that oddsmaker says Ouellet has been popular in the last few days among its customers, who are based in the United Kingdom and Ireland.
"He's doing quite well, he's been well-backed and he's been our favourite for the last 36 hours," said Felim Mac An Iomaire. "He's very fancied at the minute."
Gambling on the papacy might be considered extremely distasteful by people of faith, but it certainly is not a new practice.
Pope Gregory XIV became so irate at the practice that he issued a papal bull threatening excommunication for anyone who bet on certain Vatican affairs. That was in 1591.
While gambling isn't spelled out in the Bible as wrong, scholars note it goes against several principles of the faith itself.
In the end, it will be the cardinals who will elect the next pope during the conclave in the Sistine Chapel. It is expected to begin in mid-March.
Mac An Iomaire said his company actually took bets on the last papal election, which culminated with Pope Benedict winning in 2005.
With a pontiff firmly in place before Monday's surprise announcement, the betting on who would replace the current Pope was pretty stagnant. That all changed earlier this week.
"Our odds were already there and ready-made but what we found was as soon as the resignation was announced … it has absolutely exploded in the last 48 hours," he said.
Mac An Iomaire said Paddy Power has taken in well over 100,000 euro in bets and is quietly forecasting the papacy election to be the company's biggest ever non-sporting event.
In 2005, the company said punters bet one million euro on the race to become pope.
Mac An Iomaire said it could surpass such events such as the U.S. presidential election and reality program "X-Factor," a hugely popular talent show in Britain that is of interest to non-sports bettors.
"From the level of interest we've had from this market, it's pretty clear that people want to bet on the papal election," he said.


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In my recent conversation with Mark Schwartz, CIO of Citizenship and Immigration Services, about transitioning the federal government to agile development, we also spoke about some issues for agile contracting. It was an interesting conversation, with what I would call some good news and two challenges.
Mark is an advocate of using a multiple-award task order contact framework for contracting for agile development modules, with competition among a small group of contract holders for each module. He agrees with the view that technical developments involving the underlying architecture for these projects makes it more possible than before to do individual agile development modules as "bolt ons" to the architecture, which undermines the traditional approach that says that you need one contractor for these projects because of the difficulty of integration. He believes that the government should itself often be responsible for developing the architecture and for any integration issues, though when I said this might better be left in the hands of an architecture/integration contractor most of the time, he wasn't dogmatic on the point.
This approach reflects in my view a real possibility for getting the government a better deal by keeping a small group of vendors in real-time competition for elements of an agile development. This is also an approach that many contracting professionals in government are likely instinctively to identify with, so implementing it is mainly an educational challenge for contracting and IT folks, not a cultural challenge.
Another issue he raised is more complex. Because requirements in agile are meant to change, and to be changed easily, Mark didn't like the idea of putting any kinds of requirements in the task orders for agile projects, or of making the change order process complex in any way. He also wanted the task orders to be priced on a time and materials basis. Both, particularly the first, go against common views among contracting professionals – and to some extent of the oversight community – about having performance metrics and making sure a contract establishes what results a contractor is responsible to produce, so as to improve the likelihood that the contractor performs well.
Mark's solution to this ties in with the ongoing competition for small task orders he envisions in the multiple-award model. The government should extensively use past performance in making future task order awards as a substitute for upfront performance or other requirements.
The problem then becomes how the government knows whether the vendor's performance has been good or not absent performance requirements in the original task order. Mark argues that the government team will be observing the vendors as they are working on these short "sprints" and can see whether they are wasting time, or compare vendors in terms of production of usable code.
Well, maybe. But what if the vendors are off-site with no government people present? Or what if the sprints differ in how tough they are, so comparisons become more difficult? I also wonder if, when what is being developed in each "sprint" is fairly small, it shouldn't be easier to express performance requirements and whether there should need to be so many changes – indeed, isn't one of the aims with agile to reduce changes by reducing the scope of a project?
I'm not a techie and am raising questions rather than giving answers. I think what we really need is a dialogue among pro-agile IT people and contracting professionals about some of the ways we might deal with these issues. Good contracting people, as they should, want performance, and that's why they tend to want requirements – at least performance requirements. Pro-agile IT folks want the same thing. Is there a way to give performance requirements for an agile module?
It's time for a collegial dialogue on these issues. I would love to hear from blog readers about suggested approaches we could/should be trying – and I bet those working on these issues from both the IT and contracting sides would love to hear thoughts as well.
Posted on Sep 20, 2012 at 12:09 PM
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Save the date for 28th annual Federal 100 Awards Gala.
March 30, 2017
Seasoned government managers are hopeful about an innovation effort backed by the president, but they see pitfalls and the possibility of duplication.
Early self-reporting suggests that 81 percent of agencies are on track to electronically manage email records.
The head of the Defense Innovation Unit Experimental says his goal is to drive culture change in the DOD's acquisition and innovation processes rather than make DIUx the acquisition arm of the DOD.
A plan to reorganize DHS' cybersecurity directorate that stalled in Congress last year is still on the agency's agenda.
Without confirmed subcabinet officials, President Donald Trump's executive order calling for a federal government reorganization will be managed by agency chiefs and career executives.
As promised, a budget blueprint from the Trump administration prioritizes military and homeland security spending, and pays for increases with dramatic cuts to civilian agencies.
The key to a successful project regardless of the methodology is having a clearly defined maturity model of not just how an agency plans to execute but how it actually go about implementing and validating. With a properly defend path to maturity of documenting what your agency does well and make it repeatable, integrating off the self-contractors is no different than the integration of off the self-software. Just as efficient use of a Software API requires an API guide on how to implement so does the integration of contractors and agile development modules.The biggest obstacle is people and paper, producing paper for the sake of paper work and an aversion to continuous improvement. An aversion which arises through complacency "the cheese has moved "or those who fear loss of power/position due to a new favor or location of the cheese has changed. Define your "Capability", make repeatable, "Mature" and Lean "Agility". Having workers with systems level knowledge with oversight of what's expected and how the system should function with purview, linkage and traceability across boundaries is key to successful agility.
Harry - good point that switching contractors undermines CI. Best I can say on that is that the government integrators need to capture lessons learned, but there is definitely a trade-off here. As for the architecture, a government team owns it and participates with each of the agile teams, so I don't necessarily see that as a problem.
Good discussion. A key ingredient for building great software is continuous improvement (CI). Constantly switching teams and staff for different parts of the system (multi-award bpa) will undermine CI. And it ignores that architecture gets refactored too, based on evolving capability. Who owns the whole? In fact, fed procurement in general is anti-continuous improvement. And as such undermines software best practices. Take FAR Part 9.5 - OCI provisions. To separate the "specifiers" from the "builders" is to break a key accountability. This drives size, complexity, cost and risk through the roof. The following note does a better job of explaining this issue. http://www.softwareinsanity.com/2012/09/oci-nixes-ci.html
There are numerous items that are critical for success of an agile project in government, and several have been mentioned in this article and comments. Here are a few tactical, but key items we have found to be helpful: * Government/Customer committed involvement in the product backlog grooming is key. Requirements definition and understanding is evolutionary and the only way to evolve the most valuable solution for the customer is for the customer to be actively engaged. * Regarding multi-vendors supporting a larger project there are several items we have found useful: All the teams should be on the same sprint cadence. A common code repository, common backlog management tool (ALM), a common build pipeline (Continuous Integration) that includes automated build/compile, unit testing, smoke test, and promotes the solution to automated acceptance testing. It is critical that the solution is integrated early, frequently, and never is allowed to have modules diverge. Integration debt will derail you big-time! Many of the integration challenges can be identified in the early stages of a project by forcing the premature modules and solutions to integrate early. It is true that these early solutions is not very functional, but having these fledgling modules start to communicate with each other early is critical for transparency in what really is working. Over time, these modules continue to work together and mature together. This builds communications not only between the modules, but among the teams and the customer. * Typical supporting documentation deliverables should be iterative and maintained throughout the project, per sprint, and delivered at the end. Available for review at anytime. For a new project, the first 'release' is often the most difficult working through the deployment wickets. Consider either a very small release initially, or anticipate the first release will often be a bit longer (~6 months). The key is to create a repeatable model so that you can push product into production relatively quickly. This will also help to reduce the 'kitchen sink' syndrome where the traditional requirements process will not feel they need to throw everything into the list because they won't see a product for 18 months. * Consider shorter sprint lengths. I've spoke with many folks across government that are 'doing agile' and their sprint lengths are all over the place. I've heard sprints that are 3 months long (what is that?), I've heard of variable sprint lengths, but often hear of 1 month sprints. We typically use 2 week sprints. We have found that we can't actually plan in detail for a month's worth of work. If the release goal is every 4 months, only having 4 sprints to adjust the direction and understanding would make me nervous. Great discussion!
As far as contracting efforts are concerned, one approach we're piloting is articulating the solution architecture and business requirements in the RFP and then identifying the "deliverables" from the development vendors as successfuly completed sprints. Each sprint is defined in intensive planning sessions involving government representatives (both IT and business) as well as the systems development contractor. We agree to a fixed sprint schedule (currently adhering to 4 week sprints) and we expect our vendor to complete 80% of the story points assigned to a given sprint. Our hope is that this allows us to tie contractor performance to pay yet doesn't tie our hands on the requirements up front.
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text:
Scania Truck Driving Simulator
Scania Truck Driving Simulator | PC
Simulation, for automobiles, truck
Companies responsible for Scania Truck Driving Simulator
SCS Software | game developer
Rondomedia | publisher
Scania Truck Driving Simulator release date for PC:
game language:
08 June 2012 | Worldwide
08 June 2012 | Europe
Game mode: single player , size: 1 DVD
0 Game score 7.9 / 10 calculated out of 540 players' votes.
Expectations before the premiere: 9.4 / 10 calculated out of 195 players' votes.
Get behind the wheel of one of the most iconic trucks on the road with this highly detailed Scania R-series simulation. Simulation reality is pushed to the extreme, in this unique mix of video game and simulation, designed to have mass appeal to anyone who loves trucking!
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PEGI Rating
System requirements
Recommended: Core 2 Duo 2.4 GHz, 2 GB RAM (4 GB RAM - Vista/7), graphic card 1 GB (GeForce 450 GTS or better), Windows XP/Vista/7


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1954 When I'm Eating Jell-O I Wish I Were a Whale Print Currently priced at $ 12.99 Full Page, full color approx 13 1/2 x 10, When I"m eating Jell-O I wish I were a whale....". Scan does not show full ad. All advertisements are ORIGINAL ad"s, not reproductions. All ad"s come packaged in a protective plastic cover, WAS SCANNED IN THE COVERING. The ad"s in...
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Hey guys, I'm looking for a way to get a MAC to either authenticate or at least access shared files on a Server 2003 Server. Does anyone know of a link or tutorial?
http://www.macwindows.com/Win2003.html - This should answer ANY question you can think of when it comes to MAC & Server 2000!
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This may help too http://www.microsoft.com/downloads/d...DisplayLang=en It for SBS 2003 and 2003 server MLF
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Summary: Cyclin, N-terminal domain
Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.
This is the Wikipedia entry entitled "Cyclin". More...
Cyclin Edit Wikipedia article
Cyclins are a family of proteins that control the progression of cells through the cell cycle by activating cyclin-dependent kinase (Cdk) enzymes.[1]
Cyclins were originally discovered by R. Timothy Hunt in 1982 while studying the cell cycle of sea urchins.[2][3]
In an interview for "The Life Scientific" (aired on 13/12/2011) hosted by Jim Al-Khalili, R. Timothy Hunt explained that the name "cyclin" was originally named after his hobby cycling. It was only after the naming did its importance in the cell cycle become apparent. As it was appropriate the name stuck.[4] R. Timothy Hunt: "By the way, the name cyclin, which I coined, was really a joke, it's because I liked cycling so much at the time, but they did come and go in the cell..."[4]
Cyclins were originally named because their concentration varies in a cyclical fashion during the cell cycle. (Note that the cyclins are now classified according to their conserved cyclin box structure, and not all these cyclins alter in level through the cell cycle.[5]) The oscillations of the cyclins, namely fluctuations in cyclin gene expression and destruction by the ubiquitin mediated proteasome pathway, induce oscillations in Cdk activity to drive the cell cycle. A cyclin forms a complex with Cdk, which begins to activate the Cdk, but the complete activation requires phosphorylation, as well. Complex formation results in activation of the Cdk active site. Cyclins themselves have no enzymatic activity but have binding sites for some substrates and target the Cdks to specific subcellular locations.[5]
Cyclins, when bound with the dependent kinases, such as the p34/cdc2/cdk1 protein, form the maturation-promoting factor. MPFs activate other proteins through phosphorylation. These phosphorylated proteins, in turn, are responsible for specific events during cycle division such as microtubule formation and chromatin remodeling. Cyclins can be divided into four classes based on their behavior in the cell cycle of vertebrate somatic cells and yeast cells: G1 cyclins, G1/S cyclins, S cyclins, and M cyclins. This division is useful when talking about most cell cycles, but it is not universal as some cyclins have different functions or timing in different cell types.
G1/S Cyclins rise in late G1 and fall in early S phase. The Cdk- G1/S cyclin complex begins to induce the initial processes of DNA replication, primarily by arresting systems that prevent S phase Cdk activity in G1. The cyclins also promote other activities to progress the cell cycle, such as centrosome duplication in vertebrates or spindle pole body in yeast. The rise in presence of G1/S cyclins is paralleled by a rise in S cyclins.
G1 cyclins do not behave like the other cyclins, in that the concentrations increase gradually (with no oscillation), throughout the cell cycle based on cell growth and the external growth-regulatory signals. The presence of G cyclins coordinate cell growth with the entry to a new cell cycle.
S cyclins bind to Cdk and the complex directly induces DNA replication. The levels of S cyclins remain high, not only throughout S phase, but through G2 and early mitosis as well to promote early events in mitosis.
M cyclin concentrations rise as the cell begins to enter mitosis and the concentrations peak at metaphase. Cell changes in the cell cycle like the assembly of mitotic spindles and alignment of sister-chromatids along the spindles are induced by M cyclin- Cdk complexes. The destruction of M cyclins during metaphase and anaphase, after the Spindle Assembly Checkpoint is satisfied, causes the exit of mitosis and cytokinesis.[6]
Domain structure
Cyclins are generally very different from each other in primary structure, or amino acid sequence. However, all members of the cyclin family are similar in 100 amino acids that make up the cyclin box. Cyclins contain two domains of a similar all-α fold, the first located at the N-terminus and the second at the C-terminus. All cyclins are believed to contain a similar tertiary structure of two compact domains of 5 α helices. The first of which is the conserved cyclin box, outside of which cyclins are divergent. For example, the amino-terminal regions of S and M cyclins contain short destruction-box motifs that target these proteins for proteolysis in mitosis.
There are several different cyclins that are active in different parts of the cell cycle and that cause the Cdk to phosphorylate different substrates. There are also several "orphan" cyclins for which no Cdk partner has been identified. For example, cyclin F is an orphan cyclin that is essential for G2/M transition.[9][10] A study in C. elegans revealed the specific roles of mitotic cyclins.[11][12] Notably, recent studies have shown that cyclin A creates a cellular environment that promotes microtubule detachment from kinetochores in prometaphase to ensure efficient error correction and faithful chromosome segregation. Cells must separate their chromosomes precisely, an event that relies on the bi-oriented attachment of chromosomes to spindle microtubules through specialized structures called kinetochores. In the early phases of division, there are numerous errors in how kinetochores bind to spindle microtubules. The unstable attachments promote the correction of errors by causing a constant detachment, realignment and reattachment of microtubules from kinetochores in the cells as they try to find the correct attachment. Protein cyclin A governs this process by keeping the process going until the errors are eliminated. In normal cells, persistent cyclin A expression prevents the stabilization of microtubules bound to kinetochores even in cells with aligned chromosomes. As levels of cyclin A decline, microtubule attachments become stable, allowing the chromosomes to be divided correctly as cell division proceeds. In contrast, in cyclin A-deficient cells, microtubule attachments are prematurely stabilized. Consequently, these cells may fail to correct errors, leading to higher rates of chromosome mis-segregation.[13]
Main groups
There are two main groups of cyclins:
- G1/S cyclins – essential for the control of the cell cycle at the G1/S transition,
- G2/M cyclins – essential for the control of the cell cycle at the G2/M transition (mitosis). G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase).
Specific cyclin subtypes include:
Species | G1 | G1/S | S | M |
S. cerevisiae | Cln3 (Cdk1) | Cln 1,2 (Cdk1) | Clb 5,6 (Cdk1) | Clb 1,2,3,4 (Cdk 1) |
S. pombe | Puc1? (Cdk1) | Puc1, Cig1? (Cdk1) | Cig2, Cig1? (Cdk1) | Cdc13 (Cdk1) |
D. melanogaster | cyclin D (Cdk4) | cyclin E (Cdk2) | cyclin E, A (Cdk2,1) | cyclin A, B, B3 (Cdk1) |
X. laevis | either not known or not present | cyclin E (Cdk2) | cyclin E, A (Cdk2,1) | cyclin A, B, B3 (Cdk1) |
H. sapiens | cyclin D 1,2,3 (Cdk4, Cdk6) | cyclin E (Cdk2) | cyclin A (Cdk2, Cdk1) | cyclin B (Cdk1) |
family | members |
Other proteins containing this domain
In addition, the following human proteins contain a cyclin domain:
Leland H. Hartwell, R. Timothy Hunt, and Paul M. Nurse won the 2001 Nobel Prize in Physiology or Medicine for their discovery of cyclin and cyclin-dependent kinase.[14]
- ^ Galderisi U, Jori FP, Giordano A (August 2003). "Cell cycle regulation and neural differentiation". Oncogene. 22 (33): 5208–19. doi:10.1038/sj.onc.1206558. PMID 12910258.
- ^ Evans et al., 1983, Cell 33, p389-396
- ^ http://nobelprize.org/nobel_prizes/medicine/laureates/2001/hunt-autobio.html
- ^ a b "The Life Scientific". BBC Radio 4. BBC. Retrieved 13 December 2011.
- ^ a b Morgan, DO (2007) 'The Cell Cycle: Principles of Control, Oxford University Press
- ^ Clute and Pines, (1999) Nature Cell Biology, 1, p82-87
- ^ Brown NR, Noble ME, Endicott JA, et al. (November 1995). "The crystal structure of cyclin A". Structure. 3 (11): 1235–47. doi:10.1016/S0969-2126(01)00259-3. PMID 8591034.
- ^ Davies TG, Tunnah P, Meijer L, et al. (May 2001). "Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate". Structure. 9 (5): 389–97. doi:10.1016/S0969-2126(01)00598-6. PMID 11377199.
- ^ Fung TK, Poon RY (2005). "A roller coaster ride with the mitotic cyclins". Semin. Cell Dev. Biol. 16 (3): 335–42. doi:10.1016/j.semcdb.2005.02.014. PMID 15840442.
- ^ Gerald Karp (2007). Cell and Molecular Biology: Concepts and Experiments. New York: Wiley. pp. 148, 165–170, and 624–664. ISBN 0-470-04217-6.
- ^ van der Voet, Monique; Lorson, Monique; Srinivasan, Dayalan G.; Bennett, Karen L.; van den Heuvel, Sander (2009). "C. elegans mitotic cyclins have distinct as well as overlapping functions in chromosome segregation". Cell Cycle. 8 (24): 4091–4102. doi:10.4161/cc.8.24.10171. ISSN 1538-4101. PMC 3614003. PMID 19829076.
- ^ Rahman, Mohammad M.; Kipreos, Edward (2010). "The specific roles of mitotic cyclins revealed". Cell Cycle. 9 (1): 22–27. doi:10.4161/cc.9.1.10577. ISSN 1538-4101.
- ^ "Cell cycle: Cyclin A corrections". Nature Reviews Molecular Cell Biology. 14: 692. doi:10.1038/nrm3680.
- ^ "The Nobel Prize in Physiology or Medicine 2001". The Nobel Foundation. Retrieved 2009-03-15.
External links
- Eukaryotic Linear Motif resource motif class LIG_CYCLIN_1
Further reading
- Monty Krieger; Matthew P Scott; Matsudaira, Paul T.; Lodish, Harvey F.; Darnell, James E.; Lawrence Zipursky; Kaiser, Chris; Arnold Berk (2004). Molecular cell biology (Fifth ed.). New York: W.H. Freeman and CO. ISBN 0-7167-4366-3.
This article incorporates text from the public domain Pfam and InterPro IPR006671
This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.
This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.
Cyclin, N-terminal domain Provide feedback
Cyclins regulate cyclin dependent kinases (CDKs). P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.
Literature references
Gibson TJ, Thompson JD, Blocker A, Kouzarides T; , Nucleic Acids Res 1994;22:946-952.: Evidence for a protein domain superfamily shared by the cyclins, TFIIB and RB/p107. PUBMED:8152925 EPMC:8152925
Brown NR, Noble MEM, Endicott JA, Garman EF, Wakatsuki S, Mitchell E, Rasmussen B, Hunt T, Johnson LN; , Structure. 1995;3:1235-1247.: The crystal structure of cyclin A PUBMED:8591034 EPMC:8591034
Russo AA, Jeffrey PD, Pavletich NP; , Nat Struct Biol. 1996;3:696-700.: Structural basis of cyclin-dependant kinase activation by phosphorylation. PUBMED:8756328 EPMC:8756328
Muller SJ, Caradonna S; , Biochim Biophys Acta 1991;1088:197-207.: Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase. PUBMED:2001396 EPMC:2001396
Internal database links
SCOOP: | Cyclin Cyclin_C RB_B TFIIB |
Similarity to PfamA using HHSearch: | Cyclin |
External database links
HOMSTRAD: | cyclin |
SCOP: | 1vin |
This tab holds annotation information from the InterPro database.
InterPro entry IPR006671
Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [PUBMED:12910258], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.
Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [PUBMED:11056549].
Cyclins contain two domains of similar all-alpha fold, of which this entry is associated with the N-terminal domain.Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Pfam Clan
This family is a member of clan Cyclin (CL0065), which has the following description:
This Clan contains cyclins, Transcription factor IIB (TFIIB), and the Retinoblastoma tumour suppressor proteins. These were predicted to be related by sequence [1].
The clan contains the following 10 members:
CDK5_activator Cyclin Cyclin_C Cyclin_C_2 Cyclin_N Herp-Cyclin K-cyclin_vir_C RB_A RB_B TFIIBAlignments
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
View options
We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (95) |
Full (13476) |
Representative proteomes | UniProt (20214) |
Meta (81) |
Jalview | |||||||||
PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
Format an alignment
Download options
We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
Seed (95) |
Full (13476) |
Representative proteomes | UniProt (20214) |
Meta (81) |
Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Seed source: | Prosite |
Previous IDs: | cyclin; |
Type: | Domain |
Author: | Bateman A, Sonnhammer ELL, Griffiths-Jones SR |
Number in seed: | 95 |
Number in full: | 13476 |
Average length of the domain: | 124.00 aa |
Average identity of full alignment: | 19 % |
Average coverage of the sequence by the domain: | 30.75 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
Model details: |
Model length: | 127 | ||||||||||||
Family (HMM) version: | 22 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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Colour assignments
Archea | Eukaryota |
Bacteria | Other sequences |
Viruses | Unclassified |
Viroids | Unclassified sequence |
Align selected sequences to HMM
Generate a FASTA-format file
Clear selection
This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
Tree controls
HideThe tree shows the occurrence of this domain across different species. More...
Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.
There are 11 interactions for this family. More...
Pkinase Tat K-cyclin_vir_C Cyclin_C Cyclin_N Rb_C Herp-Cyclin K-cyclin_vir_C Pkinase Cyclin_C CDIStructures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Cyclin_N domain has been found. There are 296 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
Loading structure mapping...


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MISSION VIEJO — A 23-year-old Apple Valley man died after being electrocuted at Mission Viejo High School on Thursday afternoon, Orange County Fire Authority Capt. Steve Concialdi said.
The Orange County Coroner's Office reports Daniel Pohl died Thursday just before 4 p.m. at Mission Regional Trauma Center in Mission Viejo. Concialdi told the Daily Press on Friday that Pohl was part of a three-person construction crew that was on scaffolding at a practice football field.
Concialdi said the crew was attempting to hang a banner near the wall that separated the freeway from the school when Pohl was electrocuted by 12,000-volt electrical wires.
"Somehow he came in contact with electrical lines and was electrocuted," Concialdi said.
A second crew worker climbed up the 30-foot high scaffolding and began performing CPR on Pohl. Soon after, coaches from a summer league baseball game being played on a nearby field ran over and tried to assist the other worker.
"One of the coaches ran up the scaffolding, so now you have Pohl and the other worker and the coach all up there, and the second worker stands up and comes in contact with the wire on the back of his neck," Concialdi said. "The shock knocks him down and he falls 25 or 30 feet to the ground."
Both victims were transported to Mission Regional Trauma Center. Officials said Pohl died at the hospital. The second worker suffered burns to his neck, hand and hip as well as injuries from his fall.
"This goes to show you how dangerous electrical lines are, and people should stay completely away from them," Concialdi said.
Anneli Fogt can be reached at firstname.lastname@example.com or 760-951-6276.
AV man electrocuted, killed in Mission Viejo
Jul 18, 2014 at 5:46 PM
Jul 18, 2014 at 5:58 PM


text:
Are You looking for Terrance Phillips from Jeddo Michigan
Journal by
I am looking for your father Terrance Phillips of Jeddo Michigan? Well he is my father also and I am looking for my sister. Do not know anything about her, So if you are looking for your father Terramce (Terry) Phillips he was born in april 1959. He lived in Jeddo MI back then. PLEASE EMAIL ME [email protected]


text:
This Classified is Closed
For Sale or Trade:
FS/FT: LCD-2 Rev 1 w/ DHC cable (US) for Beyer T1
Will Ship To: CONUS
I have a very good condition LCD-2 that I bought back in April with the large earpads. I have the wooden box and a pair of doublehelixcables that comes with it. It's terminated with a 1/8 but I can include an adapter if you want. I'm willing to trade a pair of Beyer T1 headphones. Paypal gift preferred.
Edited by driftingbunnies - 11/2/11 at 9:39pm


text:
User:Kparal/Idea:Fedora Hall of Fame
From FedoraProject
Contents |
Currently lots of people participate in the Fedora Project. Some of them devote an incredible amount of their personal time to it. But although they are known amongst people related to their area of interest, some of them might feel lack of urge to push forward and improve over time. We would like to motivate them continuously, increase their satisfaction from their work and reward them. We believe that one of the pieces of this puzzle could be a Hall of Fame, that is further described by this proposal.
Hall of Fame proposal
Hall of Fame should be a collection of ladders that display top Fedora contributors in certain areas over a certain period of time and give them credit. The suggested areas of tracked participation may include:
- Fedora Wiki - # of edits, # of new pages created
- Fedora Mailing Lists - # of replies, # of new threads created
- Fedora Forum - # of replies, # of new threads, new ranks achieved
- Red Hat Bugzilla - # of comments, # of new bugs reported, # of bugs triaged, # of bugs fixed
- Fedora Package Maintenance - # of packages owned/maintained, # of new builds, overall activity, # of new updates
- Fedora Source Code - # of commits, activity in Fedora applications
- Fedora Translations - # of translations
- Fedora Package Review - # of reviews done
- Fedora Testing - # of new updates tested, # of installation testing done, # of Test Days test cases done
- Fedora Planet - # of blogposts
These statistics should be probably displayed in the form of ladders and graphs on a separate web page, that would encompass the whole Hall of Fame. This page could be part of Fedora Community website and the UI could be similar to reports present there. Basically it could look similar to the graphs currently available on Fedora Community website, but we would like to have many many more of them and prettier :-)
The statistics should be updated regularly. It doesn't have to be real-time, but at least once a day would serve the purpose well.
A nice feature would be support for certain time snapshots (e.g. "wiki edits for the end of May") that could be linked from other sources. We foresee that the "top contributors list" and a link to Hall of Fame would be included in the Fedora Weekly News or other magazines and that could be a big motivator and a reward for some people to be listed there.
Implementation details
- Implementation team:
- Kamil Páral
- Jan Hutař
- Jan Tluka
- Marián Ganisin
- Time scope: start of June 2010 - end of August 2010
Implementation status
TODO list
- ALL: Think out the proposal thoroughly, raise questions and concerns, post them here (use Discussion page)
- ALL: Sort out with your managers how much time you can spend on this task
- ALL: Set wiki to watch this page for you and inform you on every change.
kparal: Consult this idea with a few core members of Fedora project, e.g. jlaska- Jlaska likes that idea very much. Project approved :)
- unassigned: Consult this idea with Fedora Community authors. Those are probably the same people as standing behind Statistics 2.0 project.
- unassigned: Consult idea for watching fedoraforum with Fedora Forum Community - from a quick search, it looks like they are not using CMS which have some RPC and it looks like there is no such plug-in on the CMS webpages
Interesting things that could help
- EKG - project for monitoring mailing lists, in Perl
- Repositioning myself within the Fedora Project - blogpost about Fedora statistics
- Statistics 2.0 - very similar project to ours, blogpost about it
- FAS scraper - simple tool for inspiration, ticket for inclusion into python-fedora


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More Drama: Lil Twist's Auntie Makes Kat Stacks Apologize And Lie On Camera? Kat Stacks Tells Her Side! (Claims They Threatened To Whoop Her Azz If She Didn't Say Sorry) "You Still Got A Lil D*ck" + Puts Yung La & J. Futuristic's # On Blast
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