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January 23rd, 2008, 02:58 PM | #1 |
Senior Member
Fabrication work
Introduction letter:
Hello, I wanted to stop in and introduce myself. My name is Neil. I go by Nosilla on many other boards. I wanted to let everyone know of a newer fabrication shop in Mid Michigan. It is called JP Fabrication and can be found at www.jpfaboffroad.com. The site is still in the early stages but is coming along nicelly. We are adding items to the site at a pretty good pace right now so check it often. We make bumpers for cj's yj's tj's jk's xj's, and zj's right now. We also make tirecarriers,rockrails(with and with out steps) Flat/Tube fenders with up to 7" flairs.and wrangler mirror relocation brackets. We are working out rear body armor that you will be able to get the rear flat fenders welded to as well or just use the stock flairs on them. If you don't see it on our site don't think we can't build it. You tell us what you can dream up and we will make it happen. We believe in giving the customer more than what they are paying for. We preferr to use 1/4" steel for our bumpers and rockrails rather than the 1/8 th and 3/16th that everyone else uses. Is it over kill? Probally so. You will be happy it is if the situation ever comes about. Anyways, if i can help you make your dream item happen just send me a pm or email www.jpfaboffroad.com email: email@example.com or email@example.com |
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January 23rd, 2008, 05:13 PM | #2 | |
Senior Member
parked the jeep in the road to open the gate so so my boy could play hockey, and i hear crunch, knowing my jeep was in the road i was afraid to look, my neighbors car is up against my jeep. i go out to the road, my neighbor, who are good ppl, is all im so sorry, and we'll pay for damages, she was into my jeep enough, the jeep rocked, and her car lifted upwhen she pulled forward. she pulls the car forward, her bumper is pushed down, and the tail light is broke, i look to my jeep, to see NOTHING WRONG to my suprise, she hit me right in the step of my rockrails shweeee all that happened was the paint on my step was scratched
support the sport- www.GLFWDA.org - member Quote:
January 26th, 2008, 12:06 AM | #4 |
Formerly "Gr8archer"
My JP Fabricaion Rock Rails! Great work guys!
Website got a little updating, bump for JP Fab! http://www.jpfaboffroad.com Last edited by TechJeeper; January 26th, 2008 at 12:23 AM. |
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Office Space to Rent in SE14
We have a variety of serviced offices available to rent in SE14. Each office space is offered at the best rates and suited to your individual needs and requirements.
We have a variety of serviced offices available to rent in SE14. Each office space is offered at the best rates and suited to your individual needs and requirements.
This development comprises a total of 18 units which range in size from 634 - 2,648 sq ft, all of which are self-contained with kitchen and toilet facilities included. The space is bright and airy and is offered on flexible terms at a cost-effective rate. offer.
10 high spec, luxury offices in the heart of Greenwich, ranging from 145-775sqft. Sleek lines, glass partitions and flooded with light, these offices are a welcome respite from the norm. With an opulent reception, elegant board room, lounge and relaxing breakout area, all complemented by comprehensive, state of the art IT facilities, you will not find any offices to this standard in the surrounding area.
Indicative size range: 263 - 4,592 sq ft (24 - 427 sq m). This is a brand new building offering studios and office space barely five minutes' walk away from Greenland Dock (the oldest of London's riverside wet docks), now a popular spot for recreation and leisure. Many of the studios benefit from stunning floor to ceiling windows and city skyline views. Why not cycle to work along the river? The centre has plenty of showers and a secure cycle rack.
A choice of two offices to rent in Greenwich/Deptford SE8 – utility bills and business rates are included in the rent. Newly decorated, use of kitchen with eating area, use of board room / meeting room is included in the price, plus Broadband and Telecom facilities are also included in the price! This business centre is ideal for up to two staff and new start-up businesses.
This beautifully refurbished 17th century Georgian building, has an elegant and professional look; whilst working here you will find the other tenants relaxed and friendly. Full onsite facilities management. Manned reception. 1 person rooms to large suites. 4 fully equipped kitchens. Rooms can be taken furnished or unfurnished to suit your needs. IT and telephones are quick and easy to install. Straight forward packages. Low cost deposit. Short and long term contracts.
Part of Tower Bridge Business Complex and consists of a collection of buildings that began in the Victorian age when this area first developed as a major centre for food production. Today, a collection of buildings - many having great character - have been tastefully converted to suit media-style businesses seeking a central London location but offered at a fraction of the cost of the nearby City, West End or Canary Wharf districts.
This modern, purpose built business centre benefits from a central reception offering serviced offices with personal telephone answering, secretarial services, faxing, photocopying and document binding. There is an on-site coffee shop and secure under cover parking with 24/7 access. The office suites have raised floors and suspended ceilings for ease of cable management, and central heating and comfort cooling. The minimum licence term is three months. Suites are available from £80 to £650 per week near Dockland Street, The size of the suites are between 80 sqft to 3000sqft. The rent is inclusive of heating, electricity, cleaning, furniture, post tray, reception, buildings insurance, telephone line and handset installed free of charge. Professional IT support and broadband are also offered. Conference and training rooms available for hire.
A new community of entrepreneurs and their businesses is now open in Ladywell! This centre is more than just a work space – it will be a place where you can learn, network and grow. It provides on-site free business advice, free workshops on a wide variety of practical business topics as well as access to affordable finance for start-up and growing small enterprises.
This attractive property was built 10 years ago and provides self-contained office accommodation from 495 to 757 sqft. The centre offers the flexibility of a serviced office at a fraction of the cost. The 'Tenancy at Will' agreement allows you to move into an office immediately, and to vacate when necessary. The offices are not serviced and furniture is not provided. A service charge provides for cleaning of communal parts, maintenance, buildings insurance and other facilities.
Only centre who can accommodate 2 desk offices in sq. The property was constructed in 1990 and provides 32 self-contained offices. The building has its own 24 hour security , and all units are allocated a secure parking space.
Below you can see the nearest areas to SE14 where you can find serviced offices:

subset: commoncrawl


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- Score:
- rated 0.89 / 5 stars
- Views:
- 3,411 Views
- Share Links:
- Genre:
- Comedy - Original
- done
- well
- homestarrunner
- jorb
Credits & Info
- Uploaded
- May 23, 2010 | 4:40 PM EDT
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Author Comments
A cartoon from Homestarrunner.com by me and my brother Mike Chapman.
Rated 5 / 5 stars
Imposter or not.
I love this cartoon. If you are the real Matt Chapman, I love your cartoons. If your an imposer, great choice on picking a cartoon, I love this one.
Rated 2 / 5 stars
Will The Real Matt Chapman Please Stand UP
first off matt chapman is one of the creators of homestar runner if the person who has given the screen name matt chapman is matt chapman he has the right to post this since he and I am assuming the other person mike chapman his brother created it.They have there following over on their website so why bring it here now matt?I love this episode of homestar runner I seen it a couple of times on there website and now again here which makes it three time or there abouts that I have watch this episode and I love it.It is funny especially the end I love it good work. I hoping that matt might chime in give the scoop as to why he put it hear if it is truly matt that sign up and put it hear and not a poser.would love to give more stars but not sure if this is the real matt or just some guy that stole the work from the web site and put it up hear to thinking he was cool and this would boost his stats hear. If is you matt great joreb I love homestar runner and especially love strong bad. he is my favorite of them all.
Rated 5 / 5 stars
As usual, im a homestarrunner fan myself and I just absolutely love your work! Especially this one! Its great, 10/10 and 5/5. Hope to see some new stuff in the near future and im looking forward to see some of the previous homestarruner toons as well. Cant wait!
Rated 5 / 5 stars
You did a great jorb making this!
Great animation, amusing script, good voice actors, worthy of 10/10!
The only thing I can say is to make more of these! I definitally enjoy watching stuff from Homestar Runner.
Rated 4.5 / 5 stars
What a nice birthday present!
I had been a loyal fan of Homestar Runner for years now and I was also a fan of Newgrounds. I find it amazing that you finally decided to submit perhaps the most famous flash cartoon of all time to Newgrounds! I love watching this because it is great to see how far Homestar Runner has gotten. The animation and humor are still very impressive even by modern standards. I hope that this is the real Matt Chapman finally coming here to Newgrounds! How can Coach Z make a sound if he doesn't even have a mouth?


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SKU:9749Artist:Compatible Figures:N/ACompatible Software:DAZ Studio, PoserInstall Types:- Look at individual products in this bundle for install types
SKU:9749Artist:Compatible Figures:N/ACompatible Software:DAZ Studio, PoserInstall Types:- Look at individual products in this bundle for install types
This product includes the following products
Far beyond the lands to the north there can be found a valley of deep caves that it is said are inhabited by a race of Troglodytes. This hardy creature is brave, stubborn, quarrelsome and tough. Weary travelers would do best not to engage with such a beast, especially before mealtimes.
This original figure comes in two versions, one high resolution (30290 polygons) and one at low resolution (7590 polygons). This gives the option to load a scene with lots of figures without straining resources.
There are 4 highly detailed skin textures (Brown, Olive, Green, Grey) available both as high and low resolution. Four eye textures as high and low resolution (Blue, Green, Brown and Red). Each version comes with a conforming anatomical element set, which is moveable with advanced body controls. There are lots of morphs available with both versions, the higher resolution figure having slightly more facial morphs.
There are three sets of smart props, small horns for the side of the temple, earrings and a nose-ring. Each are available as high and low resolution versions.
The armour consists of two versions, one high resolution and one low resolution, for use with both figures available in Predatrons Troglodyte.
Each set contains a set of bracers, pauldrons, boots, armbands, helmet and armour base. All have crosstalk enabled to take on the body morphs of the base figures. Morphs are included to remove various parts of the mesh, such as removing the bones off the boots, bracers and belt. The cross braces can be removed also to leave just the belt and pants for a different look. By removing various body parts, such as leaving off one pauldron, armband or bracer, the more options are available to create a Troglodyte army of different characters.
There two sets of textures for each clothing item, with both available in high and low resolution.
There several smart prop items, nose-ring, earrings, mace, axe and shield. Each comes as both high and low resolution. The shield has several morphs, such as removing the arrow, the emblem and the shield boss, so it is possible to create several different styles. The axe has one morph to show a crack on the blade.
What's Included and Features
Features- This Bundle Pack Contains the Following Sets


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Events Calendar
GVSU Drag Show - LIB 100 US 201 Approved!
Date and Time
Thursday, March 15, 20128:00 PM - 10:00 PM
- Performing Arts Center » Louis Armstrong Theatre
The 2012 Drag Show, hosted by GVSU Housing and Residence Life will be taking place March 15, at 8pm in the Louis Armstrong Theater, located in the Performing Arts Center. The event, featuring the fierce Queens of Power Divas, if free and open to all. Please consider bringing an item to donate to the Women's Center food pantry, and also cash tips for the performers if you'd like. Check us out on facebook or #GVSUDragShow on Twitter.


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Historical flooding of Huntington Beach dates back to 1825. The most recent flooding was February 6 and 7, 1998, when a constant rainfall and heavy downpour caused street closures, intersection flooding, and up to 2-3 feet deep flooding in a mobile home park. A tornado caused damage on February 24, 1998, to a mobile home park.
Flooding can come with little warning. Residents in flood prone areas will be warned of an actual emergency condition by the sounding of a steady siren tone lasting three minutes. This signal will be provided by one or more local fire stations. Warning and emergency procedures will be announced on local cable TV, HBTV-3 (Channel 3) and radio stations KWVE (107.9 FM) abd KXMX (95.9 FM).
Although improvements to the Santa Ana River have reduced potential flood impacts, flooding in our city may occur. It may be caused by the Santa Ana River, East Garden Grove Wintersburg Channel, Talbert Channel, Huntington Beach Channel, or the Pacific Ocean. Most floods occur when the floodwaters leave the river or channels; however, abnormally large sea waves (tsunamis) from the ocean may create flooding near the coastline.
To determine if flood insurance is required for your property and to obtain flood protection advice, you may contact the Planning staff at (714) 536-5271.
Homeowner's insurance policies do not cover damage from floods. Because Huntington Beach participates in the National Flood Insurance Program (NFIP), you can purchase a separate flood insurance policy. This insurance is backed by the Federal government and is available to everyone, even for properties that have been flooded. If you don't have flood insurance, talk to your insurance agent.
Some people have purchased flood insurance because it was required when they got a mortgage or home improvement loan. Insurance is available for tenants to protect their personal property against flood loss and to property owners with older mortgages that do not require it.
More information about NFIP flood insurance requirements is available on this FEMA handout and on the internet at Fema's Website. The site contains hazard information, a general flood map, and a frequently asked question page. You may contact them at 1-888-CALL-FLOOD or visit www.floodsmart.gov.
Flood damage protection depends also on your cooperation and assistance. Here is how you can help:
When a property is located in the floodplain, all new construction or substantial improvement that equals or exceeds 50% of the building's depreciated value is required to comply with the City's floodplain overlay regulations which require elevation of residential structures. Nonresidential structures may be elevated and/or floodproofed. A completed flood elevation certificate must be submitted to the City following completion of the structure's lowest floor. FEMA elevation and floodproofing certificate forms are located below:
Flood Worksheet -- Revised October 2010
Flood Elevation Certificate Form (Expires Nov. 2018)
Flood Elevation Certificate Form for Zone A (Expires Nov. 2018)
Floodproofing Certificate Form (Expires Nov. 2018)
On December 3, 2009, FEMA released new Flood Insurance Rate Maps (FIRMs) for the City of Huntington Beach. The revised maps are slightly different from their predecessor in that the maps are provided in both a hardcopy and digital format. The most notable change to the maps includes aerial photography superimposed on each map panel that will make it easier to determine flood zone boundaries and render flood zone determinations. All other standard information presently on the maps will remain the same with exception of one discrepancy. The most recent Letter of Map Revision (LOMR) effective on March 30, 2009, which removed the southeast section of the City from flood zone "AE" to "X", is not reflected on the maps and therefore depicts the previous "AE" designation for that area. However, FEMA has revalidated the previous LOMR with new maps dated December 15, 2009 (Case No. 09-09-2810P). Copies of the new FIRMs and LOMR can be obtained at the links located below or they can be viewed online through FEMA's website. FEMA's online format allows you to print a portion of the FIRM as it pertains to your area, called a "FIRMette". Directions for searching for a particular map and making a FIRMette can be obtained by clicking on the menu item "map search" at the FEMA website www.msc.fema.gov/portal and then choosing the "View" option from the "Map Search Result" page. Should you have any questions regarding the flood maps, please contact the Planning and Building Department at (714) 536-5271.
Flood Insurance Rate Map (FIRM) December 3, 2009
Letter of Map Revision - Clarification September 2, 2009
Letter of Map Revision -- Cover Letter December 15, 2009
Letter of Map Revision December 15, 2009
Map Revision for Huntington Harbour
The flood zone boundaries of Huntington Harbour have been revised pursuant to a Letter of Map Revision (LOMR) dated September 27, 2010 (Case No. 10-09-2398P), which aligns these boundaries with the existing contours of the channels. The realignment designates all areas within the channels as flood zone AE and all non-submerged waterfront lots as flood zone X(shaded). The revised maps affect a number of waterfront properties abutting Huntington Harbour. A copy of the LOMR can be obtained at the link located below.
Letter of Map Revision September 27, 2010
Zoning Administrator meetings are held on the 1st and 3rd Wednesdays of each month. Meeting Agendas, Action Agendas, and Minutes are available to view online.
City of Huntington Beach
Planning Division
2000 Main Street
Huntington Beach, CA
Phone: (714) 536-5271
Fax: (714) 374-1648


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About Miasteczko Wilanów
Developer/Owner: Prokom Investments with IN-VI
Architect:APA Kurylowicz & Associates, Grupa 5; SDA Szcze"niak+Denier Architekci, APA K&A, Hermanowicz Rewski Architekci, Pracownia Architektury i Urbanistyki, MWH Architekci, Pracownia Architektoniczna Atelier 7, Szcze"niak+Denier Architekci, Firma Projektowa AKCENT, Hermanowicz Rewski Architekci, M#ka Sojka Architekci
Location: Warsaw, Poland
Why Miasteczko Wilanów?
Miasteczko Wilanów (MW) is the ongoing construction of a coherent neighborhood on 169 hectares within the boundaries of the city of Warsaw. A city shattered during the 20th century by two wars, over the last two decades Warsaw has too often been developed in an opportunistic, short term, incoherent way. MW is a modern edition of the urban morphology of enduring value which Warsaw lost during the last century: a mid rise, mixed use, socially inclusive, architecturally rich, street and pedestrian oriented district. MW is a community premised not only on what people want in a nascent capitalist economy: shopping malls, office buildings, entertainment, single family homes, easy parking; but also what they need to have a more fulfilling life: places of worship, education, health-care and protected natural areas. A community that drew together investors of vastly different backgrounds, and initially vastly different approaches. Now home to over 20,000 residents of different generations and backgrounds. Characteristics of the site at completion: FAR :1.4, 195 inhabitants per hectare, 80 jobs per hectare
The Battery Park City Master Plan
- Replaced what was to be a planned gated residential community with an open, inclusive, mixed-use district
- A neighborhood that began with a church, hospital and parks, rather than purely commercial activities
- Dense, human scaled, pedestrian oriented, project, which allows for the creation of parks and protection of wetlands
- An authentic architectural harmony brought about by the coordinated participation of 20 local architectural practices
- Successful for many investors with short term and high return objectives without public sector financial support


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George J. Moriarty 1923 - 2012 EAST LONGMEADOW - George J. Moriarty, 89, of Bluebird Estates, went to meet his Lord on Saturday, December 8, 2012. Mr. Moriarty, the son of the late Eugene F. and Teresa (Walsh) Moriarty was born and raised in Springfield. He spent all of his unmarried years in the Forest Park section of Springfield. He attended the local schools, graduating from the High School of Commerce. After World War II, he held various positions with local companies before joining the former Diamond Match Company. He was there for 35 years, retiring from the post of Plant Controller. He received his degree in accounting from Western New England College in 1956. After marrying the former Barbara Coburn, they moved to East Longmeadow in 1954. Almost immediately, Mr. Moriarty became involved with Town Affairs. His great love was the East Longmeadow Fire Department, of which he was a member for over 30 years, retiring as Captain. He never lost his interest in that department. Along the way, he spent 13 years as a member of the Town Appropriations Committee. After retiring from Diamond Match, he spent 15 years as a bus driver for the School Department, a career he greatly enjoyed. He was a member of St. Michael's Parish, serving as an usher at the 8 o'clock Mass for over 25 years. For over 20 years, he assisted the Town Clerk with all local, state and national elections. Mr. Moriarty was an active member of the East Longmeadow Lions Club, serving for over 50 years, including two terms as Club President. He also found time to donate over 12 gallons of blood to the blood programs. He leaves two sons, Richard and his wife, Therese and Donald and his wife, Joy all of East Longmeadow and his daughter Joanne Amaral with Dennis Eldridge of Billerica, MA, 9 grandchildren, April and her husband, Seth, Daniel, Christopher, Steven, Krista, James, Timothy, Jonathan and Jeffrey and 6 great-grandchildren. He was predeceased by his wife of 46 years, Barbara Moriarty in 1996, his 3 brothers, Charles, John and Edward, his 3 sisters, Emma Payne, Grace Van Valkenburg and Alice Farrell and many nieces and nephews. George's funeral will be held on Wednesday at 8:45 AM from the Forastiere Smith Funeral Home, 220 North Main St. East Longmeadow followed by a Liturgy of Christian Burial at 10 AM in St. Michaels' Church, Maple Street, East Longmeadow. Rites of Committal will follow in Green Lawn Cemetery, Calendar Ave. East Longmeadow. Visiting hours will be held on Tuesday from 2-4 and 6-8 PM at the funeral home. Contributions in George's name in lieu of flowers may be made to the Mass Lions Eye Research Fund, C/O William Murphy, P.O. Box 6050, New Bedford, MA 02742.
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Article 422
422.16 Flexible Cords
New rule allows range hoods to be cord-and-plug connected, if they comply with new stringent requirements.
(B) Specific Appliances. (4) Range Hoods. Range hoods can be cord-and-plug connected, where all of the following conditions are met. Figure 422-2 (1) The flexible cord terminates with a grounding type attachment plug. (2) The length of the cord must not be less than 18 in. or longer than 36 in. (3) The range hood receptacle must be located to avoid physical damage to the flexible cord. (4) The range hood receptacle must be accessible. (5) The range hood receptacle must be supplied by an individual branch circuit. VIEW VIDEO [ Click Here to View ] DOWNLOAD Windows MAC If you have already been approved for reprint permission, you may right mouse click on the link above and choose "Save Target As ..." or "Save Link As ..." to save the file to your local computer. ©2005 Mike Holt Enterprises, Inc.


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Linda Ritchie, Ph.D.
Licensed Professional Counselor/Marriage & Family Therapist
Ready for change? Let's Get Started1800 Michael Faraday Drive, Suite 201, Reston, Virginia 20190
The Center for Life Strategies has both a Clinical Psychologist and a Neuropsychologist on staff. We offer a full range of psychological and neuropsychological assessment services for children, adolescents, adults, and seniors. There are many issues that can be assessed through a psychological and / or neuropsycholgical evaluation. Some common conditions include: -Learning disabilities, ADHD and attention skills -Giftedness, intellectual abilities and academic skills -Emotional functioning -Developmental disabilities, Autism, Asperger's Syndrome, language skills -Cognitive or memory problems -Dementia -Cognitive loss due to neurodegenerative disease, head injury or stroke We complete all assessments in a timely fashion and will provide...(view profile to read more)
Carlos Durana, Ph.D.
Licensed Clinical Psychologist and Licensed Professional Counselor
Ready for change? Let's Get Started4933 Auburn Ave, Suite 208, Bethesda, Maryland 20814
Understanding psychological growth and deviations from healthy developmental processes is essential in helping individuals and couples improve their situation. In my work, I make use of adaptational and motivational perspectives. Using adaptational strategies, I attend to how a client experiences, appraises, reacts, and copes with life stressors. The motivational perspective, on the other hand, attends to the fulfillment of physiological, security/safety, belongingness/love, esteem, and self-actualization or spiritual needs. It is not uncommon to be unaware of our deeper needs and motives, and the conflicts that exist between our needs and the actions used to satisfy them. In helping others, I tailor my approach to the client's goals and needs.


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Experimental movement and cinema share a rich history, an interaction that truly flowers in the 1960s with the explosion of postmodern dance and the rise of video art. Coinciding with the exhibition Degas and the Dance, Dance and Video: Interactions, on view from January 26 – April 13, 2003 in the Video Gallery (179) of the Philadelphia Museum of Art, presents six collaborations between choreographers and videographers who treat video as a new and boundless performance space.
The video program includes Blue Studio, 1975-1976, one of the earliest and most innovative examples of "video dance," by postmodern master Merce Cunningham and his then filmmaker-in-residence, Charles Atlas. Their collaboration demonstrates the possibilities video offers as a space for independent choreographic invention. Dancing to a sound collage that includes the voices of composer John Cage and painter Jasper Johns, Cunningham performs against the backdrop of footage shot outdoors, in a studio space, and against the changing colors of the two-dimensional screen.
Shot in a gymnasium at Oberlin College in January 1972, Magnesium reflects the choreographic ideals of the Judson Church, and in particular a movement language called "contact improvisation" pioneered by Steve Paxton. The grainy, black and white videotape by Steve Christiansen reveals Paxton's interest in everyday and eclectic movement sources including: martial arts, gymnastics, sports, and everyday movements.
In Smell the Flowers While You Can, 1994, video artist Johan Grimonprez has transformed Meg Stuart's choreography by relocating it and setting it to a soundtrack by Hahn Rowe with poetry by David Wojnarowicz. A duet is set in the Ghent train station, amidst bystanders with suitcases, but the video also cuts between the gestures of a pool game in progress, close-ups of the dancers at a restaurant table, and the passing Brussels subway.
Tippeke, made in collaboration with filmmaker and composer Thierry De Mey, is part of a larger dance premiered by Anne Teresa De Keersmaeker's company Rosas in 1996. The video features De Keersmaeker dancing in a dramatic forest setting and in other outdoor sites, with the choreography following from her recital of the Flemish fairytale about a young boy named Tippeke, who refuses to go home unless he is carried by his mother.
Known for his film-dances, Pascal Baes' 46 bis, rue de Belleville, 1989, explores stop-action animation to evoke the earliest cinematic studies of human motion. Shot in black and white, this duet, accompanied by tango music, is set outdoors courtyard, with the figures moving according to a linear plan mapped on the courtyard's cement.
Sonata do Mar, 1998, by Janica Draisma and Albert Jan Van der Stel, was developed with the computer technology Lifeforms. Trained in mime, classical ballet and acting, Draisma was the model for the three virtual figures seen dancing above the sea to John Cage's Sonata XII for Prepared Piano.
Dance and Video: Interactions is organized by Susan Rosenberg, Assistant Curator of Modern and Contemporary Art.


text: This video reveals how entropy sometimes creates order out of chaosEsther Inglis-Arkell2/27/13 11:20amFiled to: This is awesomeentropyScienceSci21EditPromoteShare to KinjaToggle Conversation toolsGo to permalink You would think that shaking up a box with a couple of chains inside would end in sadness and a bunch of knotted chains, but as you can see in this video, it doesn't always work out like that. These two chains - both made of plain metal beads - coil and uncoil around each other until they are completely separated. The box is shaking at about 20 Hz, or cycles per second, and the photographs were taken five seconds apart. Although we think of entropy as creating chaos, it can also create a kind of order.AdvertisementThis is not just useful in science videos. Trapping long organic polymers, including DNA, and allowing them to jiggle about, can eventually cause them to separate out from each other without any damage. In that case, there are both wide areas, where the bands can jiggle about, and narrow areas, to allow them to straighten out into long bands, without any tangles. Sometimes entropy can be helpful.Via Science Mag.


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The name "Fatih" comes from the Ottoman emperor Fatih Sultan Mehmed (Mehmed the Conqueror), and means "Conqueror" in Turkish, originally from Arabic. The Fatih Mosque built by Mehmed II is in this district, while his resting place is next to the mosque and is much visited. It was on the ruins of the Church of the Holy Apostles, destroyed by earthquakes and years of war, that the Fatih Mosque was built, and around the mosque a large prayer school.
Immediately after the conquest, groups of Islamic scholars transformed the major churches of Hagia Sophia and the Pantocrator (today the Zeyrek Mosque) into mosques, but the Fatih Mosque and its surrounding complex was the first purpose-built Islamic seminary within the city walls. The building of the mosque complex ensured that the area continued to thrive beyond the conquest; markets grew up to support the thousands of workers involved in the building and to supply them with materials, and then to service the students in the seminary. The area quickly became a Turkish neighbourhood with a particularly pious character due to the seminary. Some of this piety has endured until today.
Following the conquest, the Edirnekapı (meaning Edirne Gate) gate in the city walls became the major exit to Thrace and this gave a whole new lease of life to the neighbourhoods overlooking the Golden Horn. The Fatih Mosque was on the road to Edirnekapı and the Fatih district became the most populous area of the city in the early Ottoman period and in the 16th century more mosques and markets were built in this area, including: Iskender Pasha Mosque, once famous as a centre for the Naqshbandi order in Turkey); Hirka-i-Sharif Mosque, which houses the cloak of the Prophet Muhammad (The Mosque is in common use but the cloak is only on show during the month of Ramadan; the Jerrahi Tekke; The Sunbul Efendi Tekke and the Ramazan Efendi Tekke both in the Kocamustafapaşa district and the Vefa Kilise Mosque, originally a Byzantine church. The last four were named after the founders of various Sufi orders, and Sheikh Ebü'l Vefa in particular was of major importance in the city and was very fond of Fatih. Many other mosques, schools, baths and fountains in the area were built by military leaders and officials in the Ottoman court.
From the 18th century onwards Istanbul started to grow outside the walls, and then began the transformation of Fatih into the mass of concrete apartment buildings that we have today. This process has been accelerated over the years by fires which destroyed whole neighbourhoods of wooden houses, and a major earthquake in 1766, which destroyed the Fatih Mosque and many of the surrounding buildings, (which were subsequently rebuilt). Fires continued to ravage the old city, and the wide roads that run through the area today are a legacy of all that burning. There are few wooden buildings left in Fatih today, although right up until the 1960s the area was covered with narrow streets of wooden buildings. Nowadays, the district is largely made up of narrow streets with tightly-packed 5- or 6-floor apartment buildings.
At present, Fatih contains areas including Aksaray, Fındıkzade, Çapa, and Vatan Caddesi that are more cosmopolitan than the extreme conservative image which the district has in the eyes of many people (because of the religious community of the Çarşamba quarter within the district.) With Eminönü, which was officially an area of the Fatih district until 1928, and with its historical Byzantine walls, conquered by Mehmed II, Fatih is the "real" Istanbul of the old times, before the recent enlargement of the city that began in the 19th century.
The area has become more and more crowded from the 1960s onwards, and a large portion of the middle class residents moved to the Anatolian side and other parts of the city. Fatih today is largely a working class district, but being a previously wealthy area, is well-resourced, with a more thoroughly established community than the relatively poorer residents of the newly-built areas such as Bağcılar or Esenler to the west, which are almost entirely inhabited by post-1980s immigrants who came to the city in desperate circumstances. Fatih, at least, was built with some degree of central planning by the municipality.
Besides the Haliç University and the Kadir Has University, two different Faculty of Medicine campuses of Istanbul University (Çapa Faculty of Medicine and Cerrahpaşa Faculty of Medicine) are in Fatih.
Moreover, since 1586, the Orthodox Christian Patriarchate of Constantinople has its headquarters in the relatively modest Church of St. George in the Fener district of Fatih.
Fatih has many theatres, including the famous Reşat Nuri Sahnesi. The area is well-served with a number of schools, hospitals and public amenities in general. As Fatih is next to Eminönü, there is a smaller choice of shopping than in other areas, but there are still boutiques on the main thoroughfares, many of which still carry a fair number of trees. A number of Istanbul's longest-established hospitals are in Fatih, including the Istanbul University teaching hospitals of Çapa and Cerrahpaşa, the Haseki Public Hospital, the Samatya Public Hospital, and the Vakıf Gureba Public Hospital. A tramway runs from the docks at Sirkeci, through Sultanahmet, and finally to Aksaray, which is a part of Fatih.
Also, the headquarters of some of the main units of the Istanbul Metropolitan Municipality, including the Fire Authority of the city, are based in Fatih.
Fatih has many historical and modern libraries, including the Edirnekapı Halk Kütüphanesi, Fener Rum Patrikhanesi Kütüphanesi (the Library of the Patriarchate), Hekimoğlu Ali Paşa Halk Kütüphanesi, İstanbul University Cerrahpaşa Tıp Fakültesi Kütüphanesi, İstanbul Üniversitesi Kardiyoloji Ensitütüsü Kütüphanesi, İstanbul Üniversitesi Tıp Fakültesi Hulusi Behçet Kitaplığı, İstanbul Büyükşehir Belediyesi Kadın Eserleri Kütüphanesi, Millet Kütüphanesi, Mizah Kütüphanesi, Murat Molla Halk Kütüphanesi, Ragıppaşa Kütüphanesi, and Yusufpaşa Halk Kütüphanesi.
On the other hand, today Fatih is known as one of the most conservative areas of Istanbul because of the religious residents of the Çarşamba quarter which is essentially a very minor part of this historical district. Çarşamba is famous with bearded men in heavy coats, the traditional baggy 'shalwar' trousers and Islamic turban; while women dressed in full black gowns are a common sight as this area is popular with members of the Naqshbandi Sufi order affiliated to a Sheikh. Conservative parties always do well in this area.
Today, there are still remnants of the sea walls along the Golden Horn and along the Marmara shore, to give a sense of the shape of the old walled city. There are also a number of important architectural structures in the Fatih district, including the Valens Aqueduct across the Atatürk Bulvarı, the fortress on the city walls at Yedikule, the Byzantine Palace of Porphyrogenitus, the Roman column of Marcian, the Fethiye Cami (the former Byzantine church of Christ Pammakaristos), the Kariye Camii (the former Byzantine church of the Chora), Gül Camii (another former Byzantine church), Fenari Isa Camisi (a complex of two Byzantine churches), the Greek Patriarchate with the Church of St. George in the Fener district, the Yavuz Selim Camii, and the Fatih Mosque itself.
The tombs of some of the famous sultans, including Mehmed II 'the Conqueror' (Fatih Sultan Mehmed) and Selim I 'the Grim' (Yavuz Sultan Selim) as well as other leading statesmen of the Ottoman Empire, including Gazi Osman Pasha are in Fatih.


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today's second biz ladies post comes from pamela stanmire of pillows and throws. pamela is focusing on retail today, and providing tips for keeping your retail business alive and thriving. she's touching on topics like payroll, rent, overhead and inventory with tips to keep all of them under control in tough times. if you've ever thought of expanding your online business into the realm of brick and mortar stores, this is a great primer for getting your shop started in the recession. thanks to pam for her great advice!
CLICK HERE for Pam's full post after the jump!
Hi everyone. My name is Pamela Stanmire and I am a longtime retail veteran
and avid Design*Sponge reader. Since I am writing an article about retail, I
suppose a little background is in order. My experience in brick and mortar
retail ranges from my early days as a store manager to my later experience
as a director of operations for a very fashion-forward women's retailer.
Over the years, I've worked for various retail chains large and small. My
gig for the past few years has been running my own online retail business,
PillowsandThrows.com. Even with this lousy economy, we're in the midst of
launching a second online store and our very first brick and mortar location
here in downtown Savannah, GA. Not easy in these times but we are being as
creative as possible finding ways to get it done.
That is what brings me to the topic of this article. Since we are opening
the brick and mortar store, I have spent an inordinate amount of time over
the past few months visiting neighborhoods bustling with retail
establishments and scouting out a location for our new store. Needless to
say that during the course of this process over the past several months, the
economy has tanked. I have sadly seen some independent stores that were once
very full of shoppers and activity shut their doors for good. It is not
just happening locally either. I have friends all over the US telling me
that stores are shuttering left and right. It truly breaks my heart to see
this happen. With all the retail closings, I started thinking about what
went wrong, besides the obvious lack of sales, and what could have been done
to perhaps prevent the closing.
Not that I want to sound too cliché here but sometimes when you are in a
tough situation, it can be very difficult to see the forest through the
trees. It really does help to have a friend come along and look at the
situation and state the obvious. When I am in a tough spot, I often overlook
the clearly evident solution because I am overwhelmed with the details and
thus miss seeing that proverbial forest. My goal here today is to toss out a
few helpful ideas that are rather obvious but may be getting overlooked in
the muddle of confusion and worry most struggling shopkeepers are feeling
right now.
Retailers are facing challenges that are unprecedented. This is especially
true of the small independent shops and boutiques. Things are extremely
tough and there is no need to sugarcoat the fact that you have to take
action to pull through this and to position yourself to thrive when the
economy recovers. Once you have come to terms with the fact that that is not
going to be a quick or painless recovery and decide that you are going to
face this head on, you have taken the first step towards making the changes
that may save your business. I know that maintaining your positive outlook
is tough with day-to-day sales slumping and it goes without saying that
slumping sales make it even tougher to pay your bills. You'll need to be
smart and proactive to weather this economic storm and that means a good
hard look at where you are at right now and where the money is going.
Having been faced with declining sales due to this recession, so many
retailers have had a knee-jerk reaction in a misguided attempt to lure in
the reluctant shoppers. Put everything on sale! Let's move some inventory!
While a sale can be a way to generate some quick cash in a desperate
situation, the lure of the sale has lost its luster in recent weeks. With so
many retailers running deep discounts in an attempt to draw in shoppers,
these same shoppers are now being quite accustomed to, and dare I say almost
immune, to the 50 – 75% off sale signs that are posted in the windows of so
many shops and boutiques. Not to mention the fact that this strategy is
going to kill your business in the long run. Why will anyone ever want to
pay full price ever again for a product that was 75% off for the better part
of 2009? These deep discounts run the risk of damaging a brand's value or a
retailer's reputation and that damage may be irreparable in many cases, even
when the economy does bounce back. My best advice is to resist the urge to
put your entire store on sale.
So, other than deep discounts, what else can a retailer do to pull through
this recession and still keep the doors open for business in the future?
Let's start with the most obvious…
Let's assume you've already looked at and taken action with your payroll
expenses. With slumping sales and as a practical business owner, you have
already reviewed payroll and have had to make the hard choices that no one
ever wants to have to make. You have let all non-essential staff go and you
have taken a close look at what the term "essential staff" even means to
your individual business in this economic environment. You have conducted a
thorough review of what you need to do to keep things rolling along
financially without sacrificing the level of customer service your business
needs in order to continue to generate sales. Each situation is unique. What
was essential to your business even a few months ago may be excess now. You
have made the cuts where you needed to and it broke your heart to see your
beloved employees go. It was painful but you made it through the really hard
part and survived. Now let's focus on what is left to do because what is
left to do is much easier than saying good-bye to people that so often feel
like an extension of your family.
What's Next?
With payroll trimmed back to bare bones staff, a quick review of the
finances shows that for any retailer, the cost of inventory and
rent/overhead are usually the next two biggest expenses to maintain. With
that in mind, let's look at how to adapt those costs accordingly and be
creative in our thinking process.
Let's think about inventory first. There are a couple of avenues here that
may be great options if you are willing to think outside the box and step
away from what may be your comfort level.
Just about everyone that sells consumer goods is hurting right now,
including the vendors that you buy wholesale from. The fact that your cash
flow is very tight and you have little to no Open-to-Buy hurts the vendors
that you purchase from on a routine basis as much as it hurts your business
to not buy new goods to display in your store.
I see this as an opportunity to be creative. With vendors that you have a
strong established relationship with, you may wish to approach the subject
of consignment. The vendor gets the goods off the shelf of their studio or
warehouse and into a retail venue where it is directly accessible to
consumers to purchase. You now have fresh merchandise to fill your store.
This fresh product is in keeping with your store's identity since it is a
brand that you already have established in your store and it is a brand that
customers expect to find in your establishment.
Of course, as with anything that I am suggesting in this article, you will
want to have all details in writing once both parties have agreed upon terms
of the consignment. Details such as the length of time for the consignment,
the exact quantity of products to be taken for the consignment, terms of
payment after the consignment ends, shipping details and who is covering the
shipping costs should all be outlined in your agreement with the vendor
prior to the merchandise being shipped to your store.
The next idea I am going to suggest may be a bit more painful. So, let's set
our egos aside here for a moment and look at the big picture and the
ultimate survival of your business, as uncomfortable as it may be. Is you
store just too big to keep adequately stocked with fresh merchandise in this
economic environment? Would you be better off in a smaller space where you
are not locked into carrying so much inventory? It really is basic math. A
smaller space equals less money needed to maintain inventory levels.
I recently saw a local retailer do something that I though was a very smart
move. This retailer moved from a very large multi-level retail space to a
much more modest single story space directly across the street. I took a
good look around the new space and this retailer has also pared down their
inventory to the strongest categories and products that they are able to do
volume with and have sold off the superfluous inventory that required so
much floor space and therefore made for a much higher rent (while not giving
much of a return back in sales volume). The new location is leaner and
meaner and better equipped to handle the downturn due to the smaller
location (which equals less overhead), scaled back staff, and the reduced
amount of inventory. It's also not necessarily a "forever" thing either.
When things turn around, they can always go back to a larger space if they
so desire at that time. Maybe they won't. Running leaner and meaner may be
the new business model that they stick to since it has now proved to be
Rent and Overhead
This brings up the subject of the commercial landlord. If you are struggling
to meet the month-to-month rent, don't be scared or shy to approach the
individual or company you are leasing commercial space from. Speak up if you
are struggling to pay your rent. Landlords are people too and they have
bills to pay themselves. Many landlords would be willing to be flexible and
accommodate you however they can to keep income coming in from their
property. If you default on the lease, it is obviously not good for the
landlord or for you (especially considering that you are legally bound to
the terms of that lease).
Talk to your landlord. How flexible is the lease? Can you get out early if
you absolutely need to and what penalties, if any, would be involved? Does
he have a smaller property nearby that you could move you into instead of
the larger space you are currently struggling with? Now more than ever,
landlords may be willing to work with you based on extenuating economic
circumstances. Once again everything needs to be in writing and you should
also consider consulting with your attorney regarding any changes to your
If all else fails, and moving to a smaller space is not an option, look for
alternatives outside of the box. Remember, other retailers and businesses
are also struggling. Perhaps you can find a way to team up with a
complimentary business and split the rent.
Get creative and use your imagination. Is it possible to share space with
another retailer or business that complements your product? If you sell
decorative home accessories in your store and you have a friend struggling
with a floral design studio, would you be a good match to share retail space
until business bounces back? If you sell aromatherapy products and your
neighbor has a small yoga studio, would it work for her to move her yoga
classes into your retail space in the evenings when your store is typically
closed anyhow? Your sister-in-law has an artisan jewelry studio and you sell
handcrafted clothes. Sounds like a perfect opportunity to team up and share
overhead and expenses. Not only can you share expenses for the immediate
future but who knows? You may find that there are some interesting retail
combinations that can come to light from such parings.
Sharing space and being creative can be a tremendous way to cut back on the
amount of inventory you have to carry in your retail location and give you a
partner to help you with the overhead of rent and utilities during these
tough times. Of course, you will need to check your local zoning laws and
city codes before you make any such changes. You will also need to review
the situation with your landlord to make sure you are not violating your
lease. Last but not least, as I mentioned earlier, you will want to get
every single detail in writing from all parties involved.
I know these are very tough times but I really think that a little
resourceful thinking can go a long way to helping you get through the
downturn. Hopefully, I've given you a few ideas that will get your wheels
turning and have you moving in the right direction. And remember, you are
not alone in this. Everyone is struggling right now and sometimes all it
takes to find a solution is to talk to someone about it. Don't let yourself
get so bogged down with worry and details that you can't see to find your
way though the forest.
Great article. I think that retailers as well as shoppers are getting back to basics. Solid products at realistic prices represent a value to the consumer. Add in excellent service, and I think small retailers are in a good position to weather the storm by paying attention to the consumers. Peoples values are changing, and the big box stores sales are reflecting this as well.
Thank you Pam! I manage an independently owned stationery store in MI, and your article really hits home. Times are tough, and we're really tightening our belts, but we're also seeing that when tested…the strong not only survive, but thrive. If we keep our focus and continue to do the right things, we know that we'll pull through. Everyone should check out the 3/50 project for a reminder on how important it is to shop locally: http://www.the350project.net/home.html.
Excellent !
I truly believe that small business are safer now and can take a better care of a customer who will feel personalized.
Love the web site!
Forever! -
Thanks so much for the encouragement! I am so glad that there are people out there telling us store owners to be realistic and not give up!
I work for a medium sized women's clothing catalog, Soft Surroundings, and we've been facing a lot of challenges with the economy. We've been doing ok, but have had to implement many of the things Pam has mentioned, one being expanding more into retail. Times are tough, but things will bounce back.
Great article, Pam! I'm not a retailer, but I make kids' gift items & sell them wholesale & on consignment to small boutiques. so this has been a good insight into the retailer's perspective.
Pam, I'm learning just as much, being an artisan looking for consignment opportunities. Booth sharing with other complementary artists at shows is a good way to help cut our expenses too.
Very helpful, encouraging info. Thanks!
I am an arts administrator artist who has been wanting to open a gallery for a long time. My gut says now is a good, not a bad time, to do so (rents down, and other shops closing, leaving behind perfect locations, etc.). I think you just gave very sound advice, Pam, and I agree with EB above on all her thoughts. I feel this 'back to basics' movement was already happening (perhaps in tandem with the 'green' movement?) –long before retailers could grasp hold of what was obviously becoming a trend. It is the perfect time to recharge, stimulate more creative thinking (you see many more inventions and requests for patents during a recession!) and maintain a strong, positive attitude. The self-confidence and smart decisions will not only benefit your own health, but your wealth. If your business appears upbeat and successful, your customers will feel it, too. No one wants to shop where all signs point 'doom and gloom'! I only see opportunity ahead. Thank you for the article.
Thank you for such thoughtful and honest insight.
WOw. So simple yet so smart.
Thanks for the article. It is always good to get a little perspective. We have been thinking along similar lines (our store is eli-phant.com), and have been looking for someone to co-locate with. Our landlord has also been very reasonable.
We also just heard from another friend of ours that she is downsizing her space too. Better than closing 3 months from now!
Also, I really encourage people to keep ordering, and don't sacrifice having fresh inventory in the store– I think we risk losing loyal customers who are accustomed to stopping in to see what's new (though it's amazing how new things can look just by moving them around a bit!). Aout a month ago we really starting bringing in more inventory again, and it has really helped our own attitude tremendously- it's always exciting to open a box of beautiful things!
Great article. I just recently downsized my shop and now share a space with another business. My shop Hermitage (hermitageisahome.com) used to carry a wider selection of home decor but now I focus solely on wallpaper which is a made to order product therefore keeping my inventory low. And then sharing a space with another business, LiT shades (litshades.com) keeps the overhead low. I pay a third in rent of what I was paying before. And because our businesses complement one another, we enjoy a nice cross over in clientele. I think we'll be seeing a lot more businesses pairing up in this economy. Customers appreciate doing their shopping in one place and businesses enjoy the cut in overhead.
Thank you for sharing, really a great article, learn a lot


text: Rams tight end Jared Cook recaps OTAs, talks latest charity efforts 06-24-2013 Posted by: Marc Palmer in June 24, 2013 How much fun is Jared Cook having through OTAs now that he is here in St. Louis? The Rams tight end joins us in studio to talk Rams and promote the KidSmart Push for Penchils Initiative. Related 2013-06-24 Marc Palmer tweet


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Canada is a federation of 10 provinces—Newfoundland and Labrador, Nova Scotia, New Brunswick, Prince Edward Island, Quebec, Ontario, Manitoba, Saskatchewan, Alberta, and British Columbia—and three territories—Nunavut, the Northwest Territories, and Yukon. Canada's capital is Ottawa and its largest city is Toronto. Other important cities include Montreal, Vancouver, Edmonton, Calgary, Winnipeg, Hamilton, and Quebec.
The Columbia Electronic Encyclopedia, 6th ed. Copyright © 2012, Columbia University Press. All rights reserved.


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In the first comprehensive study of the genetic basis of psoriasis, researchers at Washington University School of Medicine in St. Louis have discovered seven new sites of common DNA variation that increase the risk of the troublesome skin condition. They also found that variations in one genetic region link psoriasis and a related joint disorder, psoriatic arthritis, to four autoimmune diseases: type 1 diabetes, Grave's disease, celiac disease and rheumatoid arthritis.
"Common diseases like psoriasis are incredibly complex at the genetic level," says lead investigator Anne Bowcock, Ph.D., professor of genetics at the School of Medicine. "Our research shows that small but common DNA differences are important in the development of psoriasis. Although each variation makes only a small contribution to the disease, patients usually have a number of different genetic variations that increases their risk of psoriasis and psoriatic arthritis."
The DNA variations uncovered by the researchers point to different biological pathways that underlie psoriasis and may eventually lead to new targeted drugs and treatments that hit specific pathways, Bowcock says.
An estimated 7 million Americans have psoriasis, an autoimmune disease that occurs when the body's immune cells mistakenly attack the skin. The condition is characterized by red, scaly patches that can be itchy, painful or both. Some 10 to 30 percent of patients with psoriasis develop psoriatic arthritis, a condition that is often excruciatingly painful and debilitating.
The Washington University researchers focused on points of common variation in the genome called single nucleotide polymorphisms, or SNPs. While most of the 3 billion nucleotides that comprise DNA are thought to be identical from one person to the next, some 10 million SNPs build variation into the genome and make each individual unique. Some of these SNPs play a crucial role in a person's predisposition to disease or good health.
Using an approach known as whole genome association, the investigators scanned more than 300,000 SNPs in the genomes of 223 psoriasis patients, including 91 who had psoriatic arthritis. They compared the DNA variations in people with psoriasis to those found in 519 healthy control patients, looking for specific differences that may be linked to the disease. They then replicated their findings in a larger set of patients -- 577 with psoriasis and 576 with psoriatic arthritis -- and more than 1,200 healthy controls.
Bowcock and her team found seven novel DNA variations linked to psoriasis. Four other variations associated with the disease that had been identified previously by other researchers also were confirmed by the current study.
Whole genome association studies have recently been used to identify common genetic variations that increase the risk of diseases such as breast cancer, heart disease and type 2 diabetes. They typically involve more than 1,000 patients with a particular disease to help ensure that the genetic variations identified in the study do not occur by chance. While the current study included fewer patients, nearly half of them had a sibling and, in some cases, a parent with psoriasis, which increases the odds of finding genetic variations that contribute to the disease.
The researchers found the strongest genetic risk for psoriasis lies in a region of the genome that contains the major histocompatibility complex, a collection of genes involved in distinguishing the body's own cells from foreign invaders. "Although this region has been known to play a major role in psoriasis, DNA variations in the MHC alone have been known to not be enough to trigger disease," Bowcock says. "Only 10 percent of patients with variations in the major histocompatibility complex developed psoriasis. This tells us that other genetic or environmental factors also contribute to the disease."
One MHC variation linked to psoriasis and psoriatic arthritis occurs in the gene HCP5, the scientists noted. That variation was recently reported to delay the onset of AIDS in people infected with HIV. This is particularly interesting, Bowcock says, because psoriasis can be triggered by infection with HIV or other viruses. It may be that in people with this SNP variant, viral infection triggers a larger immune response that slows the development of AIDS but also leads to excessive inflammation in the skin and bone joints in genetically susceptible individuals, leading to the onset of psoriasis and psoriatic arthritis.
Notably, DNA variations on chromosome 4 were strongly linked to psoriatic arthritis. These same variations were also associated with psoriasis and had been previously linked to type 1 diabetes, rheumatoid arthritis, Grave's disease (caused by an overproductive thyroid gland) and celiac disease (caused by the inability to digest gluten). "Doctors have noticed that some psoriasis patients have autoimmune diseases such as celiac disease, Grave's disease, and type 1 diabetes," Bowcock says. "But we didn't know whether this was a coincidence. Now we know there is a genetic component underlying all of these diseases."
The same region of chromosome 4 contains genes that code for the signaling molecules IL2 and IL21. This opens the door to investigating whether existing drugs that block either molecule may be effective in some psoriasis patients, especially those with psoriatic arthritis.
The researchers also uncovered significant DNA variations on chromosome 13 in a genetic region involved in modifying proteins, and on chromosome 15, in a region responsible for producing a protein that activates TNF alpha (tumor necrosis factor-alpha) in a specialized immune cell known as a dendritic cell. While TNF alpha normally helps fight infections, it is thought to be a major player in psoriasis and psoriatic arthritis. Several FDA-approved psoriasis medications work by binding to TNF-alpha, thereby preventing it from communicating with cells.
Bowcock is now involved in a larger genome-wide association study of psoriasis patients and says she expects it will uncover additional genetic variations that are associated with psoriasis.
Eventually, she predicts, such studies will lead to more effective, better-targeted therapies.
"The goal of this study and other genome-association studies is to get to personalized medicine, where you can diagnose a disease and ask what genetic risk factors this person has that points to altered pathways," she says. "Then, we can target those pathways for specific therapeutic interventions."
Journal reference: Liu Y, Helms C, Liao W, Zaba LC, Duan S, Gardner J, Wise C, Miner A, Malloy MJ, Pullinger C, Kane J, Saccone S, Worthington J, Bruce I, Kwok P-Y, Menter A, Krueger J, Barton A, Saccone NL, Bowcock AM. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. Public Library of Science Genetics. April 4, 2008.
The research was supported by grants from the National Institutes of Health.
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Materials provided by Washington University School of Medicine. Note: Content may be edited for style and length.
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Happy Mother's Day! In this week's episode we chat with Dr. Ruthann Russo, author of 7 Steps to Your Best Possible Healthcare. We discuss how to use the Internet to research health issues for your family and whether services like Google Health and Microsoft Health Vault are worth it.
SPEND: Moleskin Notebooks
SAVE: TwitterSnooze
GIVE: Amish Friendship Bread (Get the starter recipe and the recipe to give to your friends when you give them the starter.)
THE Z PICK: Jeremiah of Z Recommends also stops by to talk about his homemade robots. See the robots:
Also, see Jeremiah's review of BPA-free water bottles.
Whistle for Willie by Ezra Jack Keats
Lee from Tel Aviv, Israel (not to be confused with Tel Aviv, Egypt) loves Beautiful Dorena.


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Welcome To Knightdale...
An Active, Engaged and Vibrant CommunitySeveral years ago Knightdale adopted as its motto 'Living at its Best.' Since then, that motto has become increasingly appropriate for our town. Long thought of as an interim location, between where you were and where you want to be, Knightdale has matured into a destination of its very own.
The opening of US Highway 64 Bypass and Interstate 540 have made Knightdale more convenient and easily accessible to and from all parts of the Triangle Region than ever before. Knightdale has transformed itself into an attractive place to live, work, play, shop, learn, raise a family, retire, or just visit again and again. Our convenient location just six miles east of downtown Raleigh, the state capital, offers the best of both worlds: large city amenities with major sports, museums and arts, recreation areas for fishing, boating, and water sports, and a sense of close-knit community that can only be found in a small town. Here you'll find a central location for peaceful living with easily accessible and convenient access to the state's most important metropolitan centers, beaches, and mountains. Opportunities are endless!
The 'Community' section of our website is designed to introduce you to Knightdale. Please take a look at our Chamber Membership Directory on our website. This Directory describes a community of enthusiastic, friendly people and a business community that is progressive and eager to serve your needs. Whether you are a newcomer, visitor, or longtime resident, we know your'll find our website informative and entertaining. When making your business decisions, we hope that you will support the business members listed on our site. As Chamber members, they are at the core of every success we enjoy.The Knightdale Chamber of Commerce is proud to serve the businesses and people who live and work in and around Knightdale. Making business better provides for a strong community and a healthy economy. Join us in making Knightdale not only the best place to do business, but also the best place to live...and do business!


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I�m back in the city for a few days in search of quiet spaces�both internal and external�to think, read, and write. Usually, the atelier in my apartment is very quiet. It�s a room at the back, off the street. The doves coo on the roof and there is mechanical ambient sound, but it falls into the background as I work. Today, the air has cooled and the screened window is wide open to the surrounding brick walls. There isn�t much light but I don�t need light at the computer. I�ll find that later when I take a break and go swimming in a glass enclosed pool. Yet later, I�ll take another break from a revision I�m starting to meet a friend for a coffee. Alas, some of the quietude I rely on here has been broken and the quiet space is not quiet this week. We had a bad fire in our building.
It happened at 4 a.m. last Monday morning. When we arrived from upstate later that afternoon, the fire was over but there was still a lot of activity�police, restoration crews, fire trucks. About fifteen apartments were effected�not ours thankfully�the whole roof destroyed as well as two apartments in the adjacent building. Fortunately, no one was hurt though several families have lost their homes. Most of the damage was water damage. In the aftermath, the building is busy with insurer adjusters and crews and machines drying out the walls. So, yesterday morning, I escaped across town to a writer�s room I used to belong to and thought I�d rejoin for a few months until the building is back in shape. It was a difficult trip to the other side of town in sheeting rain. The building, an old library, had been closed for renovation over the summer. Now it was reopened but still busy with workers. None of this was mentioned on their website. I regretted not calling ahead but I was desperate to find a quiet space to work. I hadn�t done a stick of work all morning and was feeling mighty frustrated.
In the end, it was my own mood that did me in. Obstacles in every direction, I hated the city in that moment. I had to calm down. I returned home, ate some lunch, and watched a recorded Antiques Roadshow with my husband for an hour. Then I returned to my desk.


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Johnny Boychuk is taken off the ice in Thursday night's game in Montreal against the Canadiens after going into the boards. Credit: Getty Images
Playing its third game in four nights, Montreal (18-9-3) fought through physical fatigue to pick up a gritty, 2-1, win over Boston (18-8-2) at the Bell Centre Thursday night.
The Canadiens are the hottest team in the NHL as they are 8-0-1 in their last 10 games and they were rewarded with first place in the Atlantic Division thanks to these two points. The Bruins have to be disappointed with the result, especially since they're off until Sunday, but losing defenseman Johnny Boychuk 4:28 into the game had to take its toll mentally on everyone in Black and Gold.
Max Pacioretty was called for a boarding penalty when he awkwardly hit Boychuk into the boards. The rugged defenseman was shaken up and initially leaned on his gloved fists. Soon, the Bruins' medical staff and EMTs brought out a backboard and he was transported to an ambulance on a stretcher that went to a local hospital. The good news is that it was later reported that Boychuk had movement in all of his extremities. Regardless, it was a very scary moment that teammates and fans won't soon forget.
The lengthy delay took some of the juice out of the first Bruins-Canadiens game of the season. Don't worry, there are three more meetings starting with Jan. 30 in Boston. Gregory Campbell had the lone goal for the Bruins, a result of a 2-on-1 with Milan Lucic late in the first period. Montreal scored both of its goals in a dominant second period (where it outshot Boston, 18-7). Tomas Plekanec beat Tuukka Rask (25 saves) from a tough angle and Pacioretty backhanded a rebound through traffic.
The Canadiens played in New Jersey Wednesday night and it showed in the third period as the Bruins outshot them, 16-6, but that's when Carey Price (32 saves) bailed them out. This was the start of a very tough stretch for the B's: they are off Friday but host Pittsburgh (20-9-1) on Saturday (7 p.m., NESN) then go to Toronto (15-11-3) on Sunday (7, NESN).
What they'll be saying: On many levels, this was a bitter loss for the Bruins. They were the much fresher team than the Canadiens which showed in the first and third period (where they outshot them 26-9). A poor second period was all it took for Montreal to escape with the victory. Obviously the loss of Boychuk for an extended period of time would prove to be extremely costly too. Kevan Miller was recalled the other day and a healthy scratch tonight but he's not Boychuk. Adam McQuaid didn't even make the trip to Montreal as his hip injury flared up again. Boston's forwards have been relatively healthy this season other than Loui Eriksson's concussion but numerous injuries to the defensemen are tough to overcome. It'll be interesting to see if Rask gets both starts this weekend. Chad Johnson played on Saturday vs. Columbus so it's likely that Bruins head coach Claude Julien will let his star goaltender play vs. the Penguins and Maple Leafs. Boston probably values the Toronto game a little more since it is an Atlantic Division contest but Pittsburgh is perhaps the B's biggest threat in the Eastern Conference. It is tough to explain how Montreal had 12 more hits (30-18) and won nine more faceoffs (41-32) than Boston. It is a given that the Canadiens will always have more power plays at home than their opposition but Boston was able to successfully kill all four penalties.
Follow Metro Boston Bruins beat writer Richard Slate on Twitter: @RichSlate


text: The strong durable Mapex S500 snare drum stand features steel tube construction which securely holds your most used drum. The Mapex S500 snare stand allows precise positioning and stable balance of your snare drum, while allowing the drum to resonate freely. Additional features are an adjustable slip proof nylon inner sleeve, 18 tooth ratchet gear snare basket tilter, double braced legs and non skid rubber feet. The Mapex S500 snare stand delivers years of service and yet remains very affordable. Mapex S500 Snare Drum Stand Features


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The Frankfurt Book Fair has the scoop on the Txtr eReader allowing us to review Kindle Vs Txtr, the WiFi eReader.
Txtr is a very Germany-centric release (Txtr is a Berlin start-up founded in 2008.), although Txtr will release in all of Europe and the US in December. After the main comparison with the Kindle (focused on use in the US) we'll review Txtr Vs Kindle in Germany and Europe.
Kindle Vs Txtr – The Main Selling Points
Kindle Vs Txtr – Wireless Store and Service
Kindle –
- AT&T or Sprint 3G depending on which Kindle you get.
- Browse Kindle Store wirelessly and get books wirelessly.
- Free Internet.
- Free Whispersync (synchronization of books).
Txtr –
- 3G EDGE/GPRS, WiFi, Bluetooth and more (see Txtr In-Depth section below).
- Txtr Net connects you to Txtr Store – navigation and downloads are free.
- Mobile Phone and Shop system in Germany by Christmas, and in Switzerland and Austria by 2010.
- Synchronizing between Txtr platform and Reader is a service that will cost 12-14 Euros per month based on contract length (12 months or 3 months).
Price, Book Availability
Txtr is 319 Euros (including VAT) and will be delivered starting December 15th.
- All of Europe and US before Christmas 2009.
- Price in the US ought to be less ($475 is too much) although that hasn't been talked about.
- 20,000 ebooks to begin with. Partnerships with Ciando, Libri Digital, Libreka, Ingram Digital and more.
Kindle is $279 in the US if you get the US & International version. Kindle is $357 or so to get to Germany i.e. 272 Euros.
- Kindle Store has hundreds of thousands of books. 350K in the US, 290K books in Germany.
- Kindle books are $9.99 in the US and $13.99 in most of Europe.
- Kindle is already available. It will start being delivered in Europe and Germany October 19th onwards.
Openness and Apps
Txtr promise a lot of openness. Their Press Release says –
In contrast to competitors, txtr Reader as well as the platform are open for developers in the form of an SDK with documented APIs.
Txtr is embracing openness in a lot of ways –
- Open for Apps from 3rd party developers.
- Open formats – there is support for PDF, ePub, Powerpoint, Word and Office 2007.
- Online platform txtr.com to publish your own texts and books.
Txtr – In Depth
Here's a Txtr Video – [youtube=http://www.youtube.com/watch?v=SmjlhATvxkY&hl=en&fs=1]
From Txtr's Brochure –
- eInk 6″ screen with 600 by 800 pixel resolution.
- Touchpad controls on the side (not a touchscreen).
- One handed operation possible.
- 3D Accelerometer for automatic screen orientation.
- An iPhone app to access Txtr functionality from iPhones.
- eInk optimized power management.
- Lithium-Polymer battery (2200 mAh).
- Wireless – EDGE/GPRS modem, BlueTooth 2.1, WiFi 802.11b/g, and 2.4 GHz wireless short-range (peer to peer).
- A connection to txtr Net (guess its their take on Kindle WhisperNet).
- Charging via USB cable.
- 8 GB expandable memory via a Micro SDHC card.
- Weighs just 300 gm and dimensions of 151 mm by 131 mm by 12 mm.
- Integration with Txtr.com online community platform and book store.
- 532 MHz Arm 11 CPU.
- (Unconfirmed) Txtr to Txtr communication and texting.
Txtr says there are 6 reasons to buy its WiFi eReader –
A good screen. It is enough to do just one thing – but do it properly. Works Naturally.
Freedom is a matter of Organization. Nobody reads just for themselves. The Future is Open.
The first three might as well apply to the Kindle. The last two are social features and openness – obvious advantages over the Kindle. Interested in what the Freedom/Organization quote hints at.
Kindle – In Depth
Please look at my Kindle 2 Review if you're in the US and at the Kindle International Review if you are in Germany or Europe.
Here's a Kindle video – [wpvideo alwBbPmy].
The top 5 features of the Kindle probably are –
- Low Price ($259) and low price books ($9.99). Higher in Europe.
- Wide Range of Books – 350K+ in the US, hundreds of thousands worldwide (Europe gets 290K or so in most countries).
- eInk screen with great readability and great battery life.
- Free Internet, Free downloads from the Kindle Store in 60 seconds. No Free Internet outside of the US.
- Innovative features like WhisperSync, Read To Me.
- Bonus: Kindle for iPhone.
The value proposition of the Kindle is very strong and the presence of refurbished Kindles only adds to your options.
In the US Kindle beats Txtr easily
The Kindle just has a lower price, a lot more books, and lots of features. While the WiFi of the Txtr is definitely a unique feature and it has other advantages like openness and Office and ePub support it just doesn't match the Kindle's value proposition.
Txtr's European price of 319 Euros (including VAT) translates to $475. You could get a DX for that price. Unless Txtr find a way to hit $300 or $325 in the US they won't be selling very many Txtrs.
Txtr Vs Kindle in Germany, Europe
For readers in Europe, and especially Germany, it's a slightly different comparison.
Kindle Advantages in Germany, Europe
- Kindle's price (after custom duties and shipping) comes to 270-280 Euros. see my International Kindle Price List for the exact price in your country. That's still 40-50 Euros cheaper than Txtr.
- Range of Kindle books is still great at 290K titles. Much more than Txtr's 20K titles.
- Unique features like WhisperSync (to sync across Kindles) and Read To Me (when not disabled by Publishers).
- The usual Kindle advantages.
Grey Areas
- How much of an impact would the Txtr to Txtr communication feature make?
- The Txtr online platform and what it brings to the table.
- Whether a lot of good Txtr Apps are created that significantly increase the Txtr value proposition.
- One crucial point will be whether Txtr Net allows for free roaming throughout Europe. That would be a major advantage for Txtr.
Basically, it's not clear how much value Txtr's social approach would bring.
The decision to open up the Txtr to developers might really pay off if developers add on one or more killer features.
Txtr Advantages in Germany and Europe
- Kindle WhisperNet is available – However, Free Internet isn't, taking away one of the Kindle's advantages.
- Books at $14 (due to wireless download fees and VAT) aren't as compelling as $9.99 Kindle books in the US.
- Txtr, being a Berlin start-up, is very Germany and Europe centric and might be able to do a good job of getting ebooks in German, French and Italian on Txtr.
- Not sure what WiFi penetration in Europe is like – However, you have to think with the population density that WiFi is an advantage for Txtr.
- Lots of format support i.e. ePub, PDF, Word, Powerpoint, etc.
The format support and WiFi are both good features.
In Europe and Germany Kindle has a slight lead, however Txtr threatens
Amazon's inability to get Free Internet, or at the minimum cheaper download prices, turns this into a tough decision. Kindle in Europe and Germany is slightly ahead of Txtr. Txtr does have the chance to leverage its base in Germany and openness to carve out a piece of the European eReader pie for itself.
The real Kindle Vs Txtr battle will probably be in 2010 when the fruits of Txtr's App Platform begin to show up.


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Mike Thompson (D-CA) introduced the Renewable Energy Parity Act of 2013 in the House of Representatives on June 25. The bill is co-sponsored by 18 other Democratic House members. The text of the bill, H.R. 2502, is available here.
The bill's title, Renewable Energy Parity Act, may appear to the uninitiated to refer to parity between renewables and fossil fuels.1 However, the reference to "parity" refers to providing the solar 30 percent investment tax credit (ITC) with a comparable effective date standard as was enacted earlier this year for the wind production tax credit (PTC).2 The desired standard is beginning of construction, rather than placed in service.
As the solar ITC has far more favorable treatment in the Internal Revenue Code than the wind PTC, it is surprising for the title of a bill benefiting solar to use the term "parity" in an unstated reference to wind. Specifically, the wind PTC, absent an extension, only applies to projects that begin construction this year. In contrast, under current law the 30 percent solar ITC applies to projects placed in service by the end of 2016. Further, after that a 10 percent ITC applies to any solar project regardless of its placed in service date. Also, wind projects that use leasing structures are ineligible for the PTC, while the ITC rules encourage leasing. Finally, the ITC is completely exempted from the alternative minimum tax (AMT) preference, while PTCs only avoid AMT's painful clutch for the first four years of a project's operation. Thus, Rep. Thompson would have needed to draft several additional pages to meet the aspiration of his bill's title of creating tax "parity" between renewable energy technologies.
The title aside, H.R. 2502 makes good policy sense. First, if enacted, it will result in more solar projects being built.3 This is good for the environment and generates jobs in America for installers, servicers and sales people. Second, projects often run into snags with permits, transmission or interconnection arrangements or weather that unexpectedly delay their completion. Such projects should not be denied a 30 percent ITC merely because such an event precluded their completion by the end of 2016.
So I support and hope the Renewable Energy Parity Act of 2013 is enacted, but if I was given only one legislative wish it would be for the availability of PTCs for wind projects that begin construction in 2014 or later.
1 See, e.g., Sen. Coons's (D-DE) Master Limited Partnerships Parity Act that would extend the benefit of a single layer of taxation regime that is available to fossil fuel investments to renewable energy investments. That bill is discussed in our blog posts available here [Aug. 1 blog post] and [Mar. 12 blog post].
2 In Notice 2013-29, the IRS published rules as to what it means to "begin construction" in 2013. The notice provides planning opportunities but also creates foot fault risk. Our client alerts discussing the notice are available here [April 16 client alert] and [April 26 client alert].
3 The bill also applies to fuel cell, microturbine, combined heat and power and small wind projects and projects that generate thermal energy from heat from the ground or ground water.
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text: Thanks, Germany, for Your Hard-Hitting Coverage of the Biggest Breasts in the WorldKatie J.M. Baker4/26/12 1:40pmFiled to: BoobsGermanytweet136EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Bild, the largest newspaper in Germany, released a map of the biggest breasts in the world yesterday. Spoiler alert: "Russian Women Have The Tightest Baskets." The map ranges from A-cup to "Greater than D-cup," because, apparently, after that your boobs are just too big for the globe to handle.AdvertisementAccording to Germany-based BILDBlog, Bild may have, shall we say, "augmented" the statistics for Germany — the average cup size for German women is C, not D. The blog also points out that the map was made over a year ago by a website called "Target Map," so it's weird that Bild is promoting it now. But, as the writer muses: "On the other hand: What journalistic diligence exercise, if you have a map of the world tits?" Gotta love Google Translator.You would think that the editors of a newspaper with a daily circulation of 3 million and enough power and influence that it basically forced the former President of Germany to resign in February after a huge corruption scandal would consider it beneath themselves to publish a dumb boob map. But apparently print is dying in Germany, too.Advertisement Germany's Best Selling Newspaper Just Published A Map Of The Biggest Breasts In The World [Business Insider]Reply136 repliesLeave a reply


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Inside Win32:Allaple
Win32:Allaple was a succesful worm few years ago. There are some instances of the worm in the wild also now, but the first boom was notably higher. The payload is a nice piece of polymorphic code, let's look how it looks and how it works.
The picture shows us the character of Allaple. The code in the new block is built from the arguments, which are moved via different ways (mov, add, or, xor, stosd have the same effect here, because the buffer was initially set to zeros). This obfuscated code continues to construct the block at 40FA84 and jump to the block immediately. Next picture shows us the mentioned code block.
We've seen this scheme before (in the first obfuscation layer). No surprise, nothing more to explain, let's move on. After finishing this block of code we can see something new, something interesting.
As described in the picture above, this code performs the decryption of another code block (which is responsible for unpacking a binary as we'll see later) and decrypts the data section (which contains the binary). The data at the beginning of first section (401000) are used to compute the decryption key. So, we have some decrypted data and another code snippet, which is shown and described bellow.
After the loading of some API functions the code tries to find its data section, which contains a PE image compressed with aPLib. Then it decompresses it and drops it. The screenshots of the packed stream (some remarkable patterns specific to LZ compressions are there) and the old well known aPLib decompressor (with its constants etc) are here:
Great, now we have the unpacked binary. It is called dmhelpserver.exe internally. It is able to register itself as a OLE object into registry and it also contains the executive part to propagate the worm over networks. Next picture shows you the list of dictionary items and the preformatted strings to construct the CLSID (it is used as the object identifier while infecting HTML pages with object injection).
The last picture will show you a part of the replicating engine. This particular snippet contains the data used to exploit a DCOM vulnerability. It's one of the ways used by Allaple to spread.
Last but not least - the original binary virustotal results http://www.virustotal.com/en/analisis/d34ac8c0bb9ca6b22413d33ce607dc78 and the dropped binary results http://www.virustotal.com/en/analisis/828d18a361867fa5d8f9a063bcb75d7a
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It very often seems that whenever conservative Republicans talk about women and anything to do with sexuality, they manage to be oafish and offensive. Mike Huckabee gives us our latest entrant into the hall of shame.
In an effort to defend Huckabee, the folks at the American Family Association added context, because the missing context was the problem, right?
Huckabee's statement didn't start off that bad:
"Women I know are smart, educated, intelligent, capable of doing anything that anyone else can do. Our party stands for the recognition of the equality of women and the capacity of women. That's not a war on them; it's a war for them."
So far so good, right? But then his next sentence was:
"If the Democrats want to insult the women of America by making them believe that they are helpless without Uncle Sugar coming in and providing for them a prescription each month for birth control because they cannot control their libido or their reproductive system without the help of government then so be it! Let us take that discussion all across America because women are far more than the Democrats have played them to be."
There is no coherent connection between the two ideas – how do you move from "women are capable" to "they can't control their libidos"?
Now, as Paul Waldman pointed out:
Huckabee's position is that saying "Democrats are treating women like dirty sluts by saying they should have access to birth control!" is very, very different from just saying women are dirty sluts. He feels he's been falsely accused of saying the latter, when he was really just saying the former. I'm sure that he thinks that if women just understood the full context of his statement, they'd realize he respects and honors them. What he doesn't get is that women actually want and need contraception, and 99 percent of women who have had sex have used some form of contraception at some point in their lives. So when he tells them that contraception is for sluts, what they hear isn't "Because I care for you, I don't want you to become a slut," what they hear is, "You're a slut."
Waldman's insight only takes us so far, though. Huckabee's statement sets up two opposite positions – birth control and self control. In his statement, Huckabee assumes the need for birth control is caused by lack of self control. He is saying that only sluts who can't conrol themselves need birth control. And since 99% of American woman use birth control, he's saying almost every American woman is a slut.
There's not a positive spin on that statement.


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Egypt & The Nile 20th April 2013 - Booked & Paid!
26 Feb 2013 nerdyfitbean asked
Hey Everyone! I'm so excited to booked and paid for my 1st ever Contiki! Egypt & The Nile on 20th April 2013. I'm from Singapore, will be traveling solo-dolo :D this time and flying in 2 days early, a whopping 13 hours flight!
Am sure it's going to be worth it! I have spoken to Contiki's representative in the latest travel fair here in Singapore, I sorta had their words of reassurance that the places we going to be visiting is not going to be affected by the protest/ strike. Things have been blown up by proportion by the media, guess they just need something to write about…. to fill media space, oh well.
Anyone going on this date 20th April, do say hi and let's start some discussion/ plan/ get to know :D
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