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A Study to Examine the Effects of Stopping Preventive Therapy for Disseminated Mycobacterium Avium Complex (DMAC) in HIV-Positive Patients
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The purpose of this study is to evaluate the effects of stopping preventive therapy for DMAC in HIV-positive patients who (1) have been treated for DMAC for at least 12 months and are now free of any signs of DMAC for at least 16 weeks, and (2) have improved immune systems (CD4 cell counts greater than or equal to 100 cells/mm3) due to anti-HIV drug therapy.
DMAC is a serious and sometimes life-threatening infection that usually affects only HIV-positive patients with CD4 cell counts (cells of the immune system that fight infection) less than 50 cells/mm3. It is recommended that people who are likely to get DMAC be placed on preventive medications which help reduce the risk of infection. New anti-HIV combination drug therapies can increase CD4 cell counts and can reduce the level of HIV in the blood. When CD4 counts are increased, risk of DMAC infection is less. This study examines whether it is possible to stop preventive therapy for DMAC when CD4 counts are high without placing individuals at risk for getting DMAC again.
Condition |
Mycobacterium Avium-Intracellulare Infection HIV Infections |
Study Type: | Observational |
Official Title: | A Study of Discontinuing Maintenance Therapy in Subjects With Disseminated Mycobacterium Avium Complex (DMAC) |
Estimated Enrollment: | 50 |
A growing body of evidence suggests AIDS-related morbidity and mortality significantly decrease where potent antiretroviral therapies are used. HAART (highly active antiretroviral therapy) seems to significantly reduce the incidence of MAC. This study tests the validity of those observations.
Peripheral blood cultures and bone marrow (aspirate) samples from 50 eligible patients previously diagnosed with disseminated Mycobacterium avium complex (DMAC) are assessed for microbiologic sterilization of MAC at the time of study entry. If either bone marrow or blood cultures test positive for MAC, patients are discontinued from study. If cultures prove sterile, patients receive 6 weeks of treatment and then discontinue MAC therapy at Week 6 (entry into Step 2 of study). They are then monitored for clinical signs and symptoms of MAC recurrence and for the presence of mycobacteria in blood cultures. In cases of increased viral load during study, modification of antiretroviral therapy is allowed at the discretion of the patient's provider.
Ages Eligible for Study: | 13 Years and older (Child, Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria
Patients may be eligible for this study if they:
- Are HIV-positive.
- Have 2 CD4 cell counts greater than or equal to 100 cells/mm3 within 60 days and 14 days prior to entry. Measurements must be taken at least 24 hours apart.
- Have been treated for DMAC with a drug regimen including at least 2 antimycobacterial drugs for at least 12 months, and have been free of symptoms for at least 16 weeks prior to study entry.
- Have been on anti-HIV therapy for at least 16 weeks and have been on stable anti-HIV therapy for at least 8 weeks prior to study entry.
- Are at least 13 years old (need consent of parent or guardian if under 18).
Exclusion Criteria
Patients will not be eligible for this study if they:
- Have any active infection (unless they have been on stable chronic suppressive therapy for at least 3 months).
- Are pregnant.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00000907
United States, California | |
Univ of Southern California / LA County USC Med Ctr | |
Los Angeles, California, United States, 900331079 | |
Willow Clinic | |
Menlo Park, California, United States, 94025 | |
Univ of California / San Diego Treatment Ctr | |
San Diego, California, United States, 921036325 | |
San Francisco AIDS Clinic / San Francisco Gen Hosp | |
San Francisco, California, United States, 941102859 | |
San Francisco Gen Hosp | |
San Francisco, California, United States, 941102859 | |
Santa Clara Valley Med Ctr / AIDS Community Rsch Consortium | |
San Jose, California, United States, 951282699 | |
San Mateo AIDS Program / Stanford Univ | |
Stanford, California, United States, 943055107 | |
Stanford Univ Med Ctr | |
Stanford, California, United States, 943055107 | |
United States, Colorado | |
Univ of Colorado Health Sciences Ctr | |
Denver, Colorado, United States, 80262 | |
United States, Florida | |
Univ of Miami School of Medicine | |
Miami, Florida, United States, 331361013 | |
United States, Georgia | |
Emory Univ | |
Atlanta, Georgia, United States, 30308 | |
United States, Hawaii | |
Univ of Hawaii | |
Honolulu, Hawaii, United States, 96816 | |
United States, Illinois | |
Rush Presbyterian - Saint Luke's Med Ctr | |
Chicago, Illinois, United States, 60612 | |
United States, Indiana | |
Indiana Univ Hosp | |
Indianapolis, Indiana, United States, 462025250 | |
Division of Inf Diseases/ Indiana Univ Hosp | |
Indianapolis, Indiana, United States, 46202 | |
United States, Maryland | |
Johns Hopkins Hosp | |
Baltimore, Maryland, United States, 21287 | |
United States, New York | |
SUNY / Erie County Med Ctr at Buffalo | |
Buffalo, New York, United States, 14215 | |
Beth Israel Med Ctr | |
New York, New York, United States, 10003 | |
Bellevue Hosp / New York Univ Med Ctr | |
New York, New York, United States, 10016 | |
Mount Sinai Med Ctr | |
New York, New York, United States, 10029 | |
United States, North Carolina | |
Univ of North Carolina | |
Chapel Hill, North Carolina, United States, 275997215 | |
United States, Ohio | |
Univ of Cincinnati | |
Cincinnati, Ohio, United States, 452670405 | |
United States, Pennsylvania | |
Univ of Pennsylvania at Philadelphia | |
Philadelphia, Pennsylvania, United States, 19104 | |
United States, South Carolina | |
Julio Arroyo | |
West Columbia, South Carolina, United States, 29169 |
Study Chair: | Judith Aberg | |
Study Chair: | Judith Currier |
ClinicalTrials.gov Identifier: | NCT00000907 History of Changes |
Other Study ID Numbers: |
Study First Received: | November 2, 1999 |
Last Updated: | July 29, 2008 |
Keywords provided by National Institute of Allergy and Infectious Diseases (NIAID):
AIDS-Related Opportunistic Infections Mycobacterium avium-intracellulare Infection Immunity, Cellular Antibiotics, Macrolide |
Mycobacterium avium Complex CD4 Lymphocyte Count Disease Progression Anti-HIV Agents |
Additional relevant MeSH terms:
Infection Communicable Diseases HIV Infections Mycobacterium Infections Mycobacterium avium-intracellulare Infection Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases |
Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases Actinomycetales Infections Gram-Positive Bacterial Infections Bacterial Infections Mycobacterium Infections, Nontuberculous |
ClinicalTrials.gov processed this record on March 30, 2017


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Search results for: |
Arts and Humanities | Viewing 1 to 10 of 487 |
Aesthetics On-Line
Aesthetics refers to the study of the arts "from a philosophic, scientific, or other theoretical standpoint." This website includes articles, reviews, and bibliographies on aesthetics; archives of the Aesthetics-L mailing list; an annotated ...
http://www.aesthetics-online.org/ |
Backyard Parties: A Brief History of DJ Culture in Southern California
This feature explores "the rise of backyard parties as [it takes] a look at the evolution of DJ culture from the 1970's to the present" in East Los Angeles and nearby areas. For each decade, explore audio, video, photos, images of flyers, e ...
http://www.kcet.org/explore-ca/web-stories/backyardparties/ |
California Video
Website for this exhibition that "reveals the variety of artistic experimentation that has occurred in the video medium throughout California over the last 40 years." The online presentation features excerpts from more than 50 videos, brows ...
http://www.getty.edu/art/exhibitions/california_video/ |
Smitten: A Love Story About Art
Companion to a documentary about Rene di Rosa, a Northern Californian art collector who "is smitten by art. For over 50 years the renowned Napa Valley collector and California art patron has been seeking out unknown and emerging artists." T ...
http://www.pbs.org/smitten/ |
Art of the First Cities: The Third Millennium B.C. from the Mediterranean to the Indus
This site is an online companion to the landmark exhibition at the Metropolitan Museum of Art which "surveys the flourishing of the world???s earliest civilizations in Mesopotamia and surrounding regions stretching from the Aegean and Eas ...
http://www.metmuseum.org/special/se_event.asp?OccurrenceId={9B8FB8E8-AE97-11D6-945F-00902786BF44} |
World Art Treasures
One of the most original cultural sites on the World Wide Web. This fantastic collection (over 100,000 slides) of art historian Jacques-Edouard Berger is being presented by his father, also a historian, Rene Berger. Currently includes: Vermeer and hi ...
http://www.bergerfoundation.ch/ |
Mother of All Art and Art History Links Page
An annotated collection of links to art history departments, research resources, image collections and exhibits, schools, museums, and more. From the School of Art and Design at the University of Michigan.
http://www.art-design.umich.edu/mother/ |
Art Safari: An Adventure in Looking for Children and Adults
The Museum of Modern Art (MoMA) presents several paintings from its collection, each containing an animal. Asked to interpret various aspects in each work and in some instances to write an original story, the participant submits the responses online. ...
http://www.moma.org/interactives/artsafari/ |
California Square Dance Council (CASDC)
Website for this group that promotes square and round dancing in California. Find listings for festivals and events, documents (such as festival and dancer how-to's), a listing of newsletters and publications from California and beyond, and details a ...
http://www.squaredance.org/CASDC_Main.htm |
California Croonin'
This small exhibition "showcases songs and sheet music about California." Features images of sheet music covers for "California Here I Come," "My San Francisco," "The Songs We Sing at Pomona," "Long Beach ...
http://libraries.claremont.edu/sc/exhibits/cacroonin/cacroonin.html |
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subset: commoncrawl


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As I was quickly flipping through the new Harper's Bazaar the other day, a story on the Italian home of shoe designer Cesare Paciotti caught my eye. I haven't been able to stop thinking about his navy and white kitchen. I have always loved white kitchens and probably always will. But the white cabinets and rustic tile floor constrasted with the glossy navy stove and hood, accentuated with shiny brass hardware is just breathtaking. Usually I don't really love the "runway to room" concepts that turn an outfit into a room, but this kitchen seems like the perfect way to infuse your home with chic nautical fashion.
See more of his home here. The views are amazing.
What do you think? Would you love a navy and white kitchen?


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Pandas were unexpected? People had been crying for Pandaren and Brewmasters since BC days.
Pandas were unexpected? People had been crying for Pandaren and Brewmasters since BC days.
I can't tell you who I am, but I can tell you who I'm not.
You mean like World of Warcraft: New Jack City?
I would roll with it.
Well, the Emerald Dream is just the ideal Azeroth, one that's kind of a paradise. It's what Azeroth should be (that is, it's an uncorrupted, unchanged Azeroth). So Kalimdor (the original, big one) still exists, there's no civilized races, it's just all natural forest and the like.
While I'm still convinced it'll be Burning Legion, the people saying that certain themes don't have "enough lore" or "enough villains" probably missed all of MoP. Lei Shen didn't exist ANYWHERE before MoP and yet he got one of the best raids in a long time devoted to him and a pretty respectable amount of lore (if you explore IoT enough and did the Kun-Lai quest lines). Pandaria existed in lore, but really the Pandaren's lore easily tripled with the expansion. If Blizzard thinks it'll be a cool concept, then it'll happen. That means anything goes if Blizz thinks it will work.
After getting high, a troll mage is going to attempt to open a portal back to his hut. It'll go completely awry and the portal will actually open up to the pony level from D3. Queue the pony invasion of Azeroth.
Originally Posted by Blizzard Entertainment
is there a book somewhere detailing events of the RoC and TFT campaigns that i missed somewhere? i keep reading people claims chen played a huge role in it but the only thing i experienced was him in the TFT bonus campaign and helped a little bit with rexxars task but outside of that i never seen him
I wouldn't mind a surprise, although its been such a long time since spacedemons that I could stand another round and the Burning Legion as well.
I really think it'll be a Burning Legion expansion. But we could all be wrong with another surprise. We'll only find out within a few months when Blizzard puts in the trademark for the expansion. Then we'll get an idea.
I cried alone every single night. It felt like every day that passed here stole another piece of my real life away. After i cried, I'd go and fight as hard as I could. My only thought was winning, moving forward, and getting stronger. — Asuna Yuuki
I personally doubt it will be anything other than a main story expansion. Obviously the next expansion is most likely going to be Burning Legion. I would say the next most likely would be Azshara which could still be related to the Burning Legion.
Blizzard needs to regain subs now, hopefully they will bring out the big guns.
I would be happy just with these
Level Cap to 100
Burning Legion expansion (pretty please)
10/12 new zones, with plenty of choices for different leveling routes (2 89-92 zones, etc)
Huge World (make it Outland x4)
Eh I don't really think they will deviate away from anything that isn't known. They will probably stick with already set themes and finish off any loose ends to wrap up the game nice and cleanly. I would surely be surprised if they did do something unexpected, a bit disappointed but it might be cool depending on what it's about. But blizzard seems to be hinting very hard at burning legion x-pac, so somethings going down with them either this coming expansion, or the one after or something like that.


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European adventure
One of the challenges of owning a supercar in Hong Kong is being able to control it in crowded places.
Most luxury car dealers offer their customers basic training in handling potentially volatile vehicles.
Usually at tracks, such courses allow devotees to legally rev-up cars without endangering other road users, and emerge a more confident driver.
The Audi Driving Experience Programme is another form of testing or learning about a luxury car.
The Bavarian marque has offered such courses for more than 30 years and last year ran 700 events for about 20,000 people in 40 countries.
Hong Kong Audi dealers Premium Motors offers a fascinating six-day, five-night Audi R8 Spyder Tuscany Tour, at HK$89,000 per pair, room and car.
Participants get to drive the R8 Spyder convertible with a 5.2-litre V10 petrol engine with petrol direct fuel injection. Capable of 525 horsepower, the convertible churns 530Nm of toque at 6,500rpm and promises 100km/h in 4.1 seconds, and a top speed of 313km/h.
Air fares are extra and a business class return fare to Munich is HK$35,219. The 20-strong, Audi-loving Hong Kong group of '10 pairs' are scheduled to take off from Chek Lap Kok on Lufthansa LH731 at 11.25pm on May 10 and land in Munich 12 hours 15 minutes later.
Lufthansa can also offer participants 5 per cent discount on first-class fares and 10 per cent on business class. Costs include comprehensive insurance, shuttles, fuels and tolls, and participants can drive in more open, more scenic roads than the congestion of Hong Kong, and acquire more driving skills from accompanying marque instructors and Premium Motors representatives.
Audi has organised a full itinerary, beginning with a tour of the marque's excellent museum and fascinating factory in Ingolstadt, 70km north of Munich.
Then the convoy will drive through the Alps to Girlan in Italy's South Tyrol and the Hotel Villa le Maschere at Barberino di Mugello, with side trips to Perugia, and/or Arezzo, Verona and then along the west bank of Lake Garda to Hotel Lefay Resort & Spa Ladi Garda, outside Gargano.
The party then return the R8 Spyders to Telfs-Buchen/Tyrol via the north bank of Lake Garda and Brennero.


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Very much a tourist town, New Hope boasts a great many stores, restaurants, art galleries, museums, and sites of historical interest, such as the Delaware Canal and the New Hope & Ivyland Railroad.
Historically, New Hope was the home of the "New Hope School" of painters, also known as the "Pennsylvania Impressionists". The town still boasts a sizeable artistic presence, as well as a very visible, thriving gay community.
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Everything you need to know about today's coverage of Israel and the Mideast. Join the Israel Daily News Stream on Facebook.
Today's Top Stories
1. Christians should take note of a brewing controversy in the PA. Mahmoud Abbas wants to remove religious affiliation from Palestinian identity cards, but he's getting resistance from Hamas and others. Khaled Abu Toameh explains why it matters:
The row that erupted shows that among Palestinians, opposition to recognition of Israel as a Jewish state remains widespread. It also shows what awaits non-Muslims in a future Palestinian state controlled by Sharia Law.
Regardless of Abbas's motives, it is clear that Hamas and other Palestinians continue to seek and Islamic state where non-Muslims would be subjected to Sharia and enjoy fewer rights. Those who think that any Christian or Jew would be welcomed under an Islamic regime are living in a delusion.
2. In Vienna, Iranian negotiators kicking off final status talks to resolve the nuclear issue. Iran's negotiating with United States, France, Britain, China, Russia, and Germany, who are collectively known as the P5+1. Today's face time only lasted 45 minutes and Iranian officials said dismantling nuclear facilities is not an option.
I saw some confusing search results referring to the same six countries as the E3+3. Confused? Josh Keating explained it all back in 2009. In any event, Iran's talks with the Fab 5+France are expected to take a year, and reports like the NY Times, Times of Israel, and BBC showed little optimism.
3. US Treasury documents clearly say the Iranian ayatollahs are backing Assad and Al-Qaida. (I did a double take too.) The Washington Post picked up on the story, but Majid Rafizadeh explains more clearly:
Several reports indicated that Assad, in fact, released many Al-Qaeda members from prison, with Iran assisting their network, in order to buttress the argument that the Assad regime was being attacked by Al-Qaeda. Reportedly, the Al-Qaeda-linked groups in Syria, Jabhat al-Nusra and ISIS have even been selling oil to the Assad regime in exchange for money and recruits with the assistance of Tehran.
In addition, the Islamic Republic can use Al-Qaeda's Iran-based network to thwart US foreign policy objectives in the region and tip the regional balance of power in favor of Iran and against other regional powers such as Israel.
Iran is also looking for alternatives in case Assad's apparatuses collapse in Syria. In other words, the Islamic Republic will support its ally as long as Assad can retain his power.
News breaks fast. Get HonestReporting alerts by e-mail
and never miss a thing.
4. Joe Hyams to Students: BDS is Most Pressing Media Challenge Today: "Unlike traditional forms of media bias from the mainstream press, which stands to lose credibility when it is shown to be violating principles of journalism, BDS thrives on media exposure."
5. Simon Plosker discussed his visit to the SodaStream factory with Tamar Yonah of Arutz Sheva. Take your pick of listening to Simon's segment or the full show. (Simon's article, which Tamar refers to during the interview, was published in the Times of Israel.)
Israel and the Palestinians
• Check out The Apartheid Smear, an excellent booklet (pdf format) produced by Professor Alan Johnson and BICOM debunking the Israel apartheid allegation and explaining how it hurts the peace process. More articles and videos at HonestReporting's resource page, The Apartheid State Libel.
• Germany's largest bank has decided that investing in Bank HaPoalim is "morally questionable." Haaretz writes:
Estimates in Israel, the report adds, are that Hapoalim was targeted because of its activity in the settlements.
• Two European companies withdrew lucrative bids to build seaports in Haifa and Ashdod. Haaretz suggests that the winds of BDS are increasingly making business with Israel politically incorrect:
Sources in the transportation sector said that Israel traditionally had trouble luring global infrastructure companies to participate in major infrastructure projects because so many have major contracts with Saudi Arabia or the Gulf states.
However, they said that some of the companies dropping out for the ports tender have no business interests in the Arab world and acted at a relatively late stage in the bidding process, well after top management had given the go-ahead to compete.
Those developments suggest that political pressure from their home countries were at work in the decision, the sources said.
- Hamas sent message to Bibi asking for restraint.
- Who are the Ansar Bayt al-Maqdis?
- Moderate rebels fire commander, leaving US without point man.


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"The fitness apps that gave me six-pack abs... (iMuscle 2) packs a great animated database of exercises." Cult of Mac
"(iMuscle 2 Android) is a very good exercise app for ideas and incidentally will review some anatomy." Tufisio.net
"Perfect for instructors and users alike, iMuscle 2 ticks a lot of the right boxes." AndroidHeadlines.com
"One of the coolest fitness apps I've used in years" FitTipDaily.com
We were delighted to see that iMuscle was featured on FOX television over the weekend as the best in class Health & Fitness workout App. See video on Fox Television
The iMuscle for iPhone was chosen by Apple as their app of the week on the App Store and subsequently shot to number one in over 50 countries!, June 2011.
iMuscle featured in iTunes Rewind 2011. The iTunes Rewind feature offer a look at what the company has judged to be the best music, movies, TV, apps, books & podcasts of the year.
Listed as one of Tech Cruch's top 20 apps of 2011 View list on Tech Crunch
"iMuscle acts as a great workout companion while you're at the gym, giving you detailed information about each workout, and letting you set up a regimen to focus on the areas of your body you want to improve. Anyone who goes to the gym and wants to learn more about specific types of workouts should check out this app." Cnet Review
iMuscle 2 is an award winning Health & Fitness app that has everything you need to plan and track your fitness program. Use our anatomically correct model to identify a muscle, view a selection of exercise results, add to a workout and get moving!
You can then track your workout progress, share your achievements and do it all over again for any of the 152 muscles mapped with any of the 600 associated exercises.
iMuscle 2 was designed with multiple users in mind, making it ideal for fitness instructors and physiotherapists.
Our anatomically correct 3D model with the musculature exposed shows superficial and many deep muscles. It's a excellent tool for learning where muscles are located and their relationship to each other.
Rotate the body and zoom into a particular area using our newly developed graphics engine. Use the scalpel tool to reveal deeper muscles. Find exercises by tapping a muscle on our 3D model or by searching our exercise database.
Convenient filters help identify exercises quickly based on type, body area worked or equipment used.
There's no guess work around how to perform exercises with iMuscle 2. Each exercise contains a detailed animation to assist you, as well as written instructions. You can even view animations full screen while you're working out! Additionally, Primary and Secondary muscles are identified and exercises can be added to workouts with the tap of a button. For a complete list of our exercise database, click here. If you can't find what you're looking for, create a custom exercise. Custom exercises are fully integrated into the app's database and contribute to your Progress & Stats.
Our interface makes it simple to create, play, organize and edit workouts. Drag & drop exercises into a workout panel and you're prompted to enter set, rep and weight details. 50 Preset Workouts allow you to get started right away.
Track your progress and stay motivated with our improved performance tracking tools. Use the Body Tracker to see where you've gained or lost inches. Workout Progress shows you statistics on strength, endurance and calories burned for an entire workout, as well as individual exercises.
Using multiple devices? No problem. Easily transfer user data and workout progress using our integrated iCloud support. Also, send your favorite workout to a friend via e-mail.
If you are having difficulty using some of the features of the app, this helpful tutorial is a great place to start. If you have further questions then you can browse through some FAQ on our support page or simply get in contact.
*PLEASE NOTE: It is currently not possible to share workouts or personal data between Android, Windows and Apple devices. Cross-platform compatibility is something we will be working towards in the future.


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