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Tuesday January 15, 2008 5:28 pm
Go Green with United Pepper
Green is Good. Definitely the newest buzzword, there is a trend now to create gadgets that are not only functional but good for the environment. Some companies rely on guilt, but others seem to believe in what they sell. Created in Vietnam and designed in Belgium, United Pepper's accessories are made of paperboard, cotton, and Kapok, a natural tree-fibre. Their Oscar USB 2.0 hub and LILI 1.3 Mpixel webcam are completely recycleable, energy efficient, and composed of fairtraded goods. It doesn't hurt that they are cute, either. Find them for £20 (~$40.00) and £30 (~$60.00) respectively on the green site.
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Unlike all other organs, the brain and spinal cord lack lymphatic vessels. Traditional thought has averred that the brain - despite having the highest basal metabolic rate of any organ - can function without such an organized network for the removal of interstitial fluid-borne metabolic waste products. We questioned this position, seeking to define the pathways by which the brain removes the potentially toxic byproducts of cellular activity. Our preliminary analysis, based on in vivo two-photon imaging, shows that low molecular weight tracers delivered to the CSF circulate surprisingly rapidly through the mouse brain, and do so along a defined anatomical route. This consists of a para-arterial inflow path, an intra-parenchymal path of interstitial flow, and a para-venous outflow path. Within the interstitial space, astrocytes support convective fluid currents, as deletion of the astrocytic watr channel AQP4 sharply reduces tracer flow along these routes. Given the continuous movement of fluid along this pathway, and its critical dependence upon astrocytic fluid transport, we propose that this system - which we designate the 'glymphatic system'- subserves a function homologous to the peripheral lymphatic system, and is essential for the clearance of metabolic waste products from the CNS. We will test the provocative hypothesis that cognitive function in an experimental model of vascular dementia in part is suppressed by accumulation of metabolic waste products. This hypothesis is based on the observation that glymphatic transport is sharply reduced in a murine model of multi-lacunar infarcts, which results in widespread trapping of small tracers in the lesioned hemisphere.
Aim 1 will use in vivo 2-photon microscopy to assess the spatial dynamics and temporal kinetics of fluorophore-tagged tracer clearance. By systematically comparing the effect of modifications of molecular sizes or surface charge upon tracer clearance, we will define the basic transport properties of the glymphatic system.
Aim 2 will extend the preliminary finding that aged mice exhibit a striking decline in glymphatic system function, and evaluate the effect that age-related suppression of arterial wall pulsation and resulting loss of convective inflow along the para-arterial path has on glymphatic function.
Aim 3 will extend the observation that intra-parenchymal fluid movement is reduced in a mouse model of multi-lacunar infarcts and evaluate whether aging cause an additional suppression of glymphatic clearance.
Aim 4 will take advantage of inducible astrocyte-specific deletion of AQP4 transgenic mice and test the hypothesis that suppressing glymphatic transport in mice with multi-lacunar infarcts will impair their cognitive functions independently of the ischemic injury. To our knowledge, these studies represent the first attempt to systematically define the mechanisms involved in the clearance of metabolic waste products from the brain on a whole-organ level. The proposed studies will provide fundamental new insight into cognitive impairment in vascular dementia, and will likely also improve our understanding of the pathophysiology of brain injury following stroke and head trauma.
Kress, Benjamin T; Iliff, Jeffrey J; Xia, Maosheng et al. (2014) Impairment of paravascular clearance pathways in the aging brain. Ann Neurol 76:845-61 |
Takano, Takahiro; He, Wei; Han, Xiaoning et al. (2014) Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices. Glia 62:78-95 |
Thrane, Alexander S; Rangroo Thrane, Vinita; Nedergaard, Maiken (2014) Drowning stars: reassessing the role of astrocytes in brain edema. Trends Neurosci 37:620-8 |
Fields, R Douglas; Araque, Alfonso; Johansen-Berg, Heidi et al. (2014) Glial biology in learning and cognition. Neuroscientist 20:426-31 |
Xie, Lulu; Kang, Hongyi; Xu, Qiwu et al. (2013) Sleep drives metabolite clearance from the adult brain. Science 342:373-7 |
Iliff, Jeffrey J; Lee, Hedok; Yu, Mei et al. (2013) Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest 123:1299-309 |
Ren, Z; Chen, X; Yang, J et al. (2013) Improved axonal regeneration after spinal cord injury in mice with conditional deletion of ephrin B2 under the GFAP promoter. Neuroscience 241:89-99 |
Wang, Fushun; Smith, Nathan A; Xu, Qiwu et al. (2013) Photolysis of caged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release. J Neurosci 33:17404-12 |
Ding, Fengfei; O'Donnell, John; Thrane, Alexander S et al. (2013) ?1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice. Cell Calcium 54:387-94 |
Rangroo Thrane, Vinita; Thrane, Alexander S; Plog, Benjamin A et al. (2013) Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain. Sci Rep 3:2582 |
Showing the most recent 10 out of 14 publications

subset: commoncrawl


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Santa Barbara Weather: 53.1°F | Humidity: 76% | Pressure: 30.06in (Rising) | Conditions: Clear | Wind Direction: South | Wind Speed: 2.7mph [see map]
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Santa Barbara Studio Artists updated: Aug 16, 2014, 10:00 AM
Santa Barbara Studio Artists presents the 13th Anniversary of their Open Studios Tour, 11 a.m. - 5 p.m. on Saturday, August 23 and Sunday, August 24, 2014. A month-long preview exhibition and an Opening Artists' Reception are also scheduled as part of the 13th Anniversary festivities. The Tour features a treasure trove of world-class original art and a view inside Santa Barbara's leading artists' private studios. Tour guests will discover an award-winning wonderland of landscape, contemporary, and figurative painting, as well as sculpture and assemblage.
Santa Barbara Studio Artists (SBSA) is a not-for-profit, juried organization of professional fine artists dedicated to raising the profile of Santa Barbara as a destination for the arts. The organization is dedicated to providing recognition and opportunities for participating professional level studio artists working in the visual arts in the Santa Barbara area. SBSA arranges small group joint exhibitions, group tours, and other opportunities for the Santa Barbara arts community.
Since its inception in 2002, the Santa Barbara Studio Artists' Tour event has doubled in size and open studio tours have gained popularity across the country as a way for artists to showcase their work, for communities to attract visitors, and to give art collectors the opportunity to purchase directly from artists at studio prices.
Distinguishing Santa Barbara Studio Artists from other open studio tours, SBSA membership is juried and participating artists are top professionals in the visual arts. Many of their works have been showcased on the walls of prestigious galleries, museums and private and corporate collections from New York and Los Angeles to Paris and elsewhere.
A complete schedule of events follows below and more information is available at www.santabarbarastudioartists.com/tour.
Schedule of Events for the 13th Annual Santa Barbara Studio Artists Open Studios Tour:
• Month-long Preview Exhibition, July 30 - August 26, 2014 The month-long Preview Exhibition features works from the Santa Barbara Studio Artists and gives attendees the opportunity to plan which of the 36 studios to visit during the two-day tour. o Date/Time: July 30 through August 26, 2014, 11 a.m. - 6 p.m. Tuesdays-Saturdays, Please call first, (805) 966-7939. o Location: Corridan Gallery, 125 North Milpas Street, Santa Barbara, CA 93103
• Open Studio Reception, August 22 , 2014 The artists will be in attendance during this festive soiree with one piece of each artist's work on display. Collectors and tour participants are invited to meet the artists and enjoy food and wine. o Date: Friday, August 22 o Time: 5 p.m. - 8 p.m. o Location: Corridan Gallery, 125 North Milpas Street, Santa Barbara, CA 93103
• Open Studios Tour (Main Event), Saturday & Sunday, August 23 & 24 Santa Barbara Studio Artists (SBSA) Open Studios Tour features a treasure trove of world-class original art and a view inside Santa Barbara's leading artists' private studios. Maps provided for self-guided driving tour through stunning back roads and estates. o Date: Saturday, August 23 and Sunday, August 24 o Time: 11 a.m. - 5 p.m. o Location: Various locations around the greater Santa Barbara area
Tickets are $20, or $15 each when purchased in groups of two or more. Ticket price includes the Open Studio Reception and the Tour. For tickets, maps and more information call 805-280-9178, or visit www.santabarbarastudioartists.com/tour
Jamee Aubrey, Splashing In The Sunset, Oil on Canvas
Kris Buck, Laguna Beach Calm, Pastel
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No Mugshot Available
Who is Raymond Terry Roberson? Was Raymond Terry Roberson arrested? When was Raymond Terry Roberson arrested? What was Raymond Terry Roberson arrested for? Is this a mugshot of Raymond Terry Roberson? Are there more Mugshots of Raymond Terry Roberson? Are Mugshot laws constitutional? Who decides which Mugshots are Indexed? Why must Mugshots remain public mugshots and public record? Is this the Raymond Terry Roberson you know?
Raymond Terry Roberson was booked in Nassau County, NY for POSSESSION OF DRUG PARAPHERNALIA, POSS OF COCAINE RESIDUE.
All are presumed innocent until proven guilty in a court of law. Published mugshots and/or arrest records are previously published public records of: an arrest, an indictment, a registration, the deprivation of liberty or a detention. The mugshots and/or arrest records published on Mugshots.com are in NO way an indication of guilt and they are NOT evidence that an actual crime has been committed. For latest case status, contact the official law enforcement agency which originally released the information.
The following Official Record of Raymond Terry Roberson is being redistributed by Mugshots.com and is protected by constitutional, publishing, and other legal rights. This Official Record was collected from a Law Enforcement agency on 2/13/2013.
Mugshots.com ID: 46494856
Race: W
Gender: M
Height: 5′ 8″ (1.73 m)
Weight: 180 lb (82 kg)
Hair Color: GRY
Eye Color: BLU
Booking Number: 20130000000414
Arrest Date: 2/13/2013
Arresting Agency: NCS
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Estate Dining
Culinary offerings are a unique and delicious part of the Biltmore experience. Menus feature fresh produce and meats from the estate itself, as well as our award-winning wines and seasonal items.
Located in Antler Hill Village and Winery
Handcrafted Cuisine located in Village Hotel
Gather at Village Social in Village Hotel and relax with friends over sustainable seafood with an inspired cuisine flair, and share plates made with regional farm ingredients prepared in a more southern and traditional way.
View DetailsLocated in Antler Hill Village and Winery
Seasonal Farm to Table Fare
Estate-raised and regionally sourced ingredients are expertly crafted by our chefs in this vibrant, casual setting that embodies the charm of Europe. Watch the chefs prepare meals in our open kitchen.
View DetailsLocated in Antler Hill Village and Winery
Global Pub Fare
Enjoy satisfying pub fare alongside robustly-flavored American and global cuisine, craft beers, spirits, and Biltmore wines. Unwind with our full bar, live music in the evening, and outdoor seating.
View DetailsLocated in Deerpark
Taste of the South Buffet
Mouth-watering Southern regional cuisine served buffet-style in a peaceful, natural setting.
Currently closed for the winter and will reopen April 1, 2017.
Located in The Inn on Biltmore Estate
Refined Elegant Dining
Experience expertly prepared cuisine with world-class service inspired by the Vanderbilts. White linen tablecloths, fine china, and crystal add to the luxury of savoring carefully executed meals.
View DetailsLocated in The Inn on Biltmore Estate
Relaxed Elegance
Enjoy a delicious offering from our menu, while relaxing with a book or just taking in the breathtaking view of the estate. We serve lunch, afternoon tea, and a late–night dinner menu.
View DetailsLocated in Biltmore House and Gardens
Appalachian Comfort Food
Satisfy your appetite for house-smoked meats, Carolina barbeque, grilled burgers, and other Southern favorites in this historic setting in what was originally the estate's horse stable. Enjoy casual dining in a bright and airy restaurant where converted stalls hold cozy booths.
View DetailsThe Bake Shop
Located in Biltmore House and Gardens
Enjoy fresh–baked pastries and baked goods, as well as excellent espresso, gourmet coffees, and herbal teas. Located in the Stable area next to Biltmore House.
View DetailsThe Conservatory Café
Located in Biltmore House and Gardens
Open air refreshments on the Conservatory's back patio. Serving Biltmore wines, light snacks, and small plates to enjoy during your visit to Biltmore's gardens.
View DetailsThe Courtyard Market
Located in Biltmore House and Gardens
Featuring gourmet hot dogs and sausages, fresh salads, snacks, draft beer, wine, and other cold beverages. Located in the Stable area next to Biltmore House.
View Details


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Quality Health Care and You - Diabetes |
Not sure of glucose reading?03/18/2011 |
Question: Being on a low carbohydrate high protein diet is it possible to get a higher glucose reading in the morning after getting a lower reading at night before bed and having fasted for 10 hours? I have not been diagnosed as a diabetic.
Yes, it is possible that the morning glucose reading could be higher than the night before, even after having fasted for 10 hours. The body's glucose is maintained 24 hours a day through several mechanisms; the actual glucose value will normally fluctuate from 90 to 110 mg/dl daily, even in a fasting state. The liver produces glucose during times of fasting, and during prolonged fasts (24 hours or longer), fat is broken down for energy.Diabetes is defined as having a fasting glucose of 126 mg/dl or higher on two different occasions, or a level greater than 200 mg/dl with symptoms (extreme thirst, urination frequently, extreme hunger, with weight loss). An A1c is a 3-month snapshot of one's glucose 24 hours, 7 days a week – normal is less than 5.8%. You can ask your doctor to do an A1c if you are concerned about having diabetes.
W. Fred Miser, MD Professor of Family Medicine Director of Ohio State Medicine Residency Program College of Medicine The Ohio State University |


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Know more about this business than we do? Cool! Please submit any corrections or missing details you may have.
Help us make it rightBe the first OregonLive.com user to add photos or videos of Vista Mortgage
Vista Mortgage is located at 8 N State St, Lake Oswego, OR. This location is in the Lakewood neighborhood. This business specializes in Real Estate Financing.


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I have it: 7 I had it: 1 I want it: 14
Designers » L » Liz Claiborne « Groups
I have it: 7 I had it: 1 I want it: 14
Sunrise by Liz Claiborne is a fragrance for women. Top notes are mango, apple and citruses; middle notes are cinnamon, carnation, jasmine, magnolia, lily-of-the-valley, iris and gardenia; base notes are amber, vetiver and musk.
Perfume rating: 3.71 out of 5 with 10 votes.
Top Notes
Middle Notes
Base Notes
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weak | 2 | |
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I have a vintage bottle of it.
Very nice after it's stayed on your skin for a bit.
It's aqueous and very Carnation. Soft and sweet.
Sillage: Moderate
Longevity: Weak
I love this scent although Im not a big gardenia fan I tolorate this because of the wonderful drydown scent left behind on this. It is a beautiful scent!! Very warm and sunshiney.
This smells sooooo good! I found it for a good price so I bought it and I was glad.It smells very young fresh and fruity the only problem was my bottle was leaking and I returned it and there wasn't anymore in the store so I am looking for another bottle but it does smell really good and better than the original Claiborne it is more up to date and fresh.
Become a member of this online perfume community and you will be able to add your own reviews.
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This page contains information, reviews, perfume notes, pictures, new ads, vintage posters and videos about Liz Claiborne Sunrise fragrance but we do not warrant the accuracy of information. Trademarks and logos belong to respected companies and manufacturers and are used solely to identify products and companies. If you have more information about Liz Claiborne Sunrise, you can expand it by adding a personal perfume review. Fragrantica has a unique user-driven classification system and you may classify Sunrise by Liz Claiborne. Click on the appropriate options on the fragrance classification form below the perfume picture. Also, you can find links to 3rd party websites/Internet stores, but Fragrantica has no access or control over those websites. We do not make guarantees nor accept responsibility for what you might find as a result of these links, or for any future consequences including but not limited to money loss. User reviews of Sunrise by Liz Claiborne represent the views of the credited authors alone and do not reflect Fragrantica's views.
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Super easy Malaysian banana dumplings with the most sexiest Coconut and Pandan custard ever.
Rojak, a Malaysian Spicy Fruit Salad, with a twist in the sauce!
Nostalgic comfort food: Malaysian tomato chicken curry.
Penang Char Kuey Teow (炒粿條). Got a wok? Fry up this timeless Malaysian hawker fare at home today!
Curry night sides: citrusy carrot salad with herbs and toasted almonds
Pan-Fried Radish Cake
Banana Spring Rolls, Coconut Tapioca Pearls, Kaffir Lime Syrup & Toasted Coconut Flakes
Crispy pork lard crackling. Mm-mmm!
Fried Lemongrass Chicken with Sambal Mayonnaise
Sambal belacan - sweet, sour, salty and spicy. It captures the essence of Malaysian cooking. A condiment that most Malaysians can't live without.
Masterchef Australia hot salami pizza. Crispy and tasty!
What you find at the hawkers, can now be cooked from the comfort of your own home! And it only takes 10 minutes or less if you move fast.
Teh Tarik (Milk Tea) Ice Cream
Kuih Keria (Malaysian Sweet Potato Doughnuts)
Chili Dungeness Crabs Dip
Malaysian butter chicken, fried chicken cooked with aromatic curry leaves, bird's eye chilli peppers and butter, one of the representative styles of Malaysian cuisine.
Traditional Chinese peanut cookies that melt in your mouth, into bits of nutty bliss oh-so addictive. There's a secret to it, though, in which East meets West.
Nasi Lemak, the classic Malaysian breakfast. Coconut rice, roasted peanuts, ingredients all the way from Malaysia and a fried egg. This is great any time of the day!
Crisp Fried Whole Snapper with Chilli and Coriander Sauce
Recipe for the king of Malaysian dishes - Assam Laksa
Mom's easy recipe for Malaysian fish head curry (sans coconut milk), cooked with eggplant, long beans and cabbage.
CharKoay Kak (Fried Rice Cake)...a very popular street food on the island of Penang, Malaysia.
Malaysian kam heong squid. Squid cooked in an incredibly aromatic concoction of curry leaves, curry powder and bird's eye chilli peppers.
A quick Malaysian stir-fry with shrimp, turmeric and dill.
Chicken Laksa... recipe has a LOT of ignredients, but the directiosn are prety easy - kinda just throw it all in apot and cook...
Loh Han Guo or Siraitia Grosvenorii With Dried Longan Drink
Creamy Butter Prawns
Beef Rendang - A Malaysian/Singaporean curry dish that is well loved!
Malaysian Curry Puff.
A classic Malaysian Dessert 'Cendol' with a twist (Mung Bean Jelly Noodles, Salted Coconut Milk and Palm Sugar & Lime Granita)
Creamy Salted Egg Crab
Malaysian Curry Puffs encased in crisp, flaky pastry
Fried Rice With Salted Mustard Green
Clams With Shaoxing Wine


text:
Tricyclic antidepressants (TCAs) are chemical compounds used primarily as antidepressants. TCAs were first discovered in the early 1950s and marketed later in the decade.[1] They are named after their chemical structure, which contains three rings of atoms. Tetracyclic antidepressants (TeCAs), which contain four rings of atoms, are a closely related group of antidepressant compounds.
Although TCAs are sometimes prescribed, they have been largely replaced in clinical use in most parts of the world by newer antidepressants such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs) and norepinephrine reuptake inhibitors (NRIs), which have fewer unpleasant side-effects.
The TCAs were developed amid the "explosive birth" of psychopharmacology in the early 1950s. The story begins with the synthesis of [2] Its psychiatric effects were first noticed at a hospital in Paris in 1952. The first widely used psychiatric drug, by 1955 it was already generating significant revenue as an antipsychotic.[3] Research chemists quickly began to explore other derivatives of chlorpromazine.
The first TCA reported for the treatment of depression was [2] Some testing of Geigy's imipramine, then known as Tofranil, took place at the Münsterlingen Hospital near Konstanz.[3] Geigy later became Ciba-Geigy and eventually Novartis.
Dibenzazepine derivatives are described in U.S. patent 3,074,931 issued 1963-01-22 by assignment to Smith Kline & French Laboratories. The compounds described share a tricyclic backbone different from the backbone of the TCA amitriptyline.
Merck introduced the second member of the TCA family, amitriptyline (Elavil), in 1961.[3] This compound has a different three-ring structure from imipramine.
The TCAs are used primarily in the clinical treatment of mood disorders such as major depressive disorder (MDD), dysthymia, and treatment-resistant variants. They are also used in the treatment of a number of other medical disorders, including anxiety disorders such as generalized anxiety disorder (GAD), social phobia (SP) also known as social anxiety disorder, obsessive-compulsive disorder (OCD), and panic disorder (PD), post-traumatic stress disorder (PTSD), body dysmorphic disorder (BDD), eating disorders like anorexia nervosa and bulimia nervosa, certain personality disorders such as borderline personality disorder (BPD), Neurological disorders such as attention-deficit hyperactivity disorder (ADHD),[4] Parkinson's disease[5] as well as chronic pain, neuralgia or neuropathic pain, and fibromyalgia, headache, or migraine, smoking cessation, tourette syndrome, trichotillomania, irritable bowel syndrome (IBS), interstitial cystitis (IC), nocturnal enuresis (NE),[6] narcolepsy, insomnia, pathological crying and/or laughing, chronic hiccups, ciguatera poisoning, and as an adjunct in schizophrenia.
Clinical depression
For many years the TCAs were the first choice for pharmacological treatment of clinical depression. Although they are still considered to be highly effective, they have been increasingly replaced by antidepressants with an improved safety and side effect profile, such as the SSRIs and other newer antidepressants such as the novel reversible MAOI moclobemide. However, tricyclic antidepressants are possibly more effective in treating melancholic depression than other antidepressant drug classes.[7] Newer antidepressants are thought to have fewer and less severe side effects and are also thought to be less likely to result in injury or death if used in a suicide attempt, as the doses required for clinical treatment and potentially lethal overdose (see therapeutic index) are far wider in comparison.
Nonetheless, the TCAs are still occasionally used for treatment-resistant depression that has failed to respond to therapy with newer antidepressants.[8] They are not considered addictive and are somewhat preferable to the monoamine oxidase inhibitors (MAOIs). The side effects of the TCAs usually come to prominence before the therapeutic benefits against depression and/or anxiety do, and for this reason, they may potentially be somewhat dangerous, as volition can be increased, possibly giving the patient a greater desire to attempt or commit suicide.[9]
Attention deficit hyperactivity disorder
The TCAs were used in the past in the clinical treatment of ADHD,[10] though they are not typically used anymore on account of being replaced by more effective agents with fewer side effects such as atomoxetine (Strattera, Tomoxetin, Attentin) and stimulants like methylphenidate(Ritalin, Focalin, Concerta), and amphetamine (Adderall, Dexedrine, Vyvanse). ADHD is thought to be caused by an insufficiency of dopamine and norepinephrine activity in the prefrontal cortex of the brain. Most of the TCAs inhibit the reuptake of norepinephrine, though not dopamine, and as a result, they show some efficacy in remedying the disorder.[11] Notably, the TCAs are more effective in treating the behavioral aspects of ADHD than the cognitive deficits, as they help limit hyperactivity and impulsivity, but have little to no benefits on attention.[12]
Chronic pain
The TCAs show efficacy in the clinical treatment of a number of different types of chronic pain, notably neuralgia or neuropathic pain and fibromyalgia.[13][14] The precise mechanism of action in explanation of their analgesic efficacy is unclear, but it is thought that they indirectly modulate the opioid system in the brain downstream via serotonergic and noradrenergic neuromodulation, among other properties.[15][16][17] They are also effective in migraine prophylaxis, though not in the instant relief of an acute migraine attack. They may also be effective to prevent chronic tension headaches.
The majority of the TCAs act primarily as serotonin-norepinephrine reuptake inhibitors (SNRIs) by blocking the serotonin transporter (SERT) and the norepinephrine transporter (NET), respectively, which results in an elevation of the synaptic concentrations of these neurotransmitters, and therefore an enhancement of neurotransmission.[18][19] Notably, with the sole exception of amineptine, the TCAs have negligible affinity for the dopamine transporter (DAT), and therefore have no efficacy as dopamine reuptake inhibitors (DRIs).[18] Both serotonin and norepinephrine have been highly implicated in depression and anxiety, and it has been shown that facilitation of their activity has beneficial effects on these mental disorders.[20]
In addition to their reuptake inhibition, many TCAs also have high affinity as antagonists at the 5-HT2[21] (5-HT2A[22] and 5-HT2C[22]), 5-HT6,[23] 5-HT7,[24] α1-adrenergic,[21] and NMDA receptors,[25] and as agonists at the sigma receptors[26] (σ1[26] and σ2[27]), some of which may contribute to their therapeutic efficacy, as well as their side effects.[28] The TCAs also have varying but typically high affinity for antagonising the H1[21] and H2[29][30] histamine receptors, as well as the muscarinic acetylcholine receptors.[21] As a result, they also act as potent antihistamines and anticholinergics. These properties are generally undesirable in antidepressants, however, and likely contribute to their large side effect profiles.[28]
Most, if not all, of the TCAs also potently inhibit sodium channels and L-type calcium channels, and therefore act as sodium channel blockers and calcium channel blockers, respectively.[31][32] The former property is responsible for the high mortality rate upon overdose seen with the TCAs via cardiotoxicity.[33] It may also be involved in their efficacy as analgesics, however.[34]
Binding profiles
The measured affinities [Kd (nM)] of selected of TCAs at different receptor or transporter binding sites are listed below:[18][21][35][36][37]
Compound | SERT | NET | DAT | 5-HT1A | 5-HT2A | 5-HT2C | 5-HT6 | 5-HT7 | α1 | α2 | D2 | H1 | mACh |
Amitriptyline | 3.13 | 22.4 | 4,430 | 320 | 24 | 6.15 | 103.1 | 114 | 26 | 815 | 1,230 | 1.03 | 13.8 |
Butriptyline | 1,360 | 5,100 | 3,940 | 7,000 | 380 | ? | ? | ? | 570 | 4,800 | ? | 1.1 | 35 |
Clomipramine | 0.21 | 45.85 | 2,605 | >10,000 | 35.5 | 64.6 | 53.8 | 127 | 3.2 | 525 | 119.8 | 31 | 37 |
Desipramine | 179 | 2.27 | 3,190 | >10000 | 315 | ? | ? | ? | 115 | 6,350 | 1,561 | 45.4 | 232.6 |
Dosulepin | 8.6 | 46 | 5,310 | 4,004 | 258 | ? | ? | ? | 470 | 2,400 | ? | 4 | 63.6 |
Doxepin | 68 | 29.5 | 12,100 | 276 | 27 | 8.8 | 136 | ? | 24 | 1,185 | 1,380 | 0.21 | 81.4 |
Imipramine | 1.6 | 51.67 | 8,500 | >10,000 | 118.67 | 120 | 190.3 | 1000 | 61 | 3,150 | 1,310 | 24 | 68 |
Iprindole | 1,620 | 1,262 | 6,530 | 2,800 | 217 | 206 | ? | ? | 2,300 | 8,600 | ? | 130 | 2,100 |
Lofepramine | 70 | 5.4 | 18,000 | 4,600 | 200 | ? | ? | ? | 100 | 2,700 | 2,000 | 360 | 67 |
Nortriptyline | 16.5 | 1.65 | 5,000 | 302 | 43 | 8.5 | 148 | ? | 58 | 2,265 | 1,885 | 8.2 | 94 |
Protriptyline | 19.6 | 1.41 | 2,100 | 3,800 | 70 | ? | ? | ? | 130 | 6,600 | 2,300 | 60 | 25 |
Trimipramine | 149 | 2,450 | 3,780 | 8,000 | 32 | ? | ? | ? | 24 | 680 | 180 | 0.27 | 58 |
The selected ligands act as antagonists or inverse agonists at receptors or as inhibitors of transporters.[18][21][35][36]
Side effects
Many side effects may be related to the antimuscarinic properties of the TCAs. Such side effects are relatively common and may include dry mouth, dry nose, blurry vision, lowered gastrointestinal motility or constipation, urinary retention, cognitive and/or memory impairment, and increased body temperature.
Other side effects may include drowsiness, anxiety, emotional blunting (apathy/anhedonia), confusion, restlessness, dizziness, akathisia, hypersensitivity, changes in appetite and weight, sweating, sexual dysfunction, muscle twitches, weakness, nausea and vomiting, hypotension, tachycardia, and rarely, irregular heart rhythms. Twitching, hallucinations, delirium and coma are also some of the toxic effects caused by overdose.[38] Rhabdomyolysis or muscle breakdown has been rarely reported with this class of drugs as well.[39]
Tolerance to these adverse effects of these drugs often develops if treatment is continued. Side effects may also be less troublesome if treatment is initiated with low doses and then gradually increased, although this may also delay the beneficial effects.
TCAs can behave like class 1A Antiarrhythmics, as such, they can theoretically terminate ventricular fibrillation, decrease cardiac contractility and increase collateral blood circulation to ischemic heart muscle. Naturally, in overdose, they can be cardiotoxic, prolonging heart rhythms and increasing myocardial irritability.
Antidepressants in general may produce a discontinuation syndrome. Since the term "withdrawal" has been linked to addiction to recreational drugs like opioids the medical profession and pharmaceutical public relations prefer that a different term be used, hence "discontinuation syndrome."[40] Discontinuation symptoms can be managed by a gradual reduction in dosage over a period of weeks or months to minimise symptoms.[41] In tricyclics, discontinuation syndrome symptoms include anxiety, insomnia, headache, nausea, malaise, or motor disturbance.[42]
The TCAs are highly metabolised by the cytochrome P450 hepatic enzymes. Drugs that inhibit cytochrome P450 (for example cimetidine, methylphenidate, fluoxetine, antipsychotics, and calcium channel blockers) may produce decreases in the TCAs' metabolism, leading to increases in their blood concentrations and accompanying toxicity.[43] Drugs that prolong the QT interval including antiarrhythmics such as quinidine, the antihistamines astemizole and terfenadine, and some antipsychotics may increase the chance of ventricular dysrhythmias. TCAs may enhance the response to alcohol and the effects of barbiturates and other CNS depressants. Side effects may also be enhanced by other drugs that have antimuscarinic properties.
TCA overdose is a significant cause of fatal drug poisoning. The severe morbidity and mortality associated with these drugs is well documented due to their cardiovascular and neurological toxicity. Additionally, it is a serious problem in the pediatric population due to their inherent toxicity[44] and the availability of these in the home when prescribed for bed wetting and depression. In the event of a known or suspected overdose medical assistance should be sought immediately.
A number of treatments are effective in a TCA overdose.
An overdose on TCA is especially fatal as they are rapidly absorbed from GI tract in the alkaline conditions of the small intestines. As a result, toxicity often becomes apparent in the first hour after an overdose. However, symptoms may take several hours to appear if a mixed overdose has caused delayed gastric emptying
Many of the initial signs are those associated to the anticholinergic effects of TCAs such as dry mouth, blurred vision, urinary retention, constipation, dizziness, and emesis (or vomiting). Due to the location of norepinephrine receptors all over the body, many physical signs are also associated with a TCA overdose:[45]
- Anticholinergic effects: altered mental status (e.g., agitation, confusion, lethargy, etc.), resting sinus tachycardia, dry mouth, mydriasis (pupil dilation), fever
- Cardiac effects: hypertension (early and transient, should not be treated), tachycardia, orthostasis and hypotension, arrhythmias (including ventricular tachycardia and ventricular fibrillation, most serious consequence) / ECG changes (prolonged QRS, QT, and PR intervals)
- CNS effects: syncope, seizure, coma, myoclonus, hyperreflexia
- Pulmonary effects: hypoventilation resulting from CNS depression
- Gastrointestinal effects: decreased or absent bowel sounds
Treatment of TCA overdose depends on severity of symptoms:
Initially, gastric decontamination of the patient is achieved by administering, either orally or via a nasogastric tube, activated charcoal pre-mixed with water, which adsorbs the drug in the gastrointestinal tract(most useful if given within 2 hours of drug ingestion). Other decontamination methods such as stomach pumps, gastric lavage, whole bowel irrigation, or (ipecac induced) emesis, are not recommended in TCA poisoning.
If there is metabolic acidosis, intravenous infusion of sodium bicarbonate is recommended by Toxbase.org, the UK and Ireland poisons advice database (TCAs are protein bound and become less bound in more acidic conditions, so by reversing the acidosis, protein binding increases and bioavailability thus decreases – the sodium load may also help to reverse the Na+ channel blocking effects of the TCA).
Treatment is otherwise supportive.
Recreational use
A very small number of cases involving non-medical use of antidepressants have been reported over the past 30 years.[46] According to the US government classification of psychiatric medications, TCAs are "non-abusable"[47] and generally have low abuse potential.[48] Several cases of the misuse[49] of amitriptyline alone[50][51] or together with methadone[49][52] or in other drug dependent patients[53][54] and of dosulepin with alcohol[55] or in methadone patients[56] have been reported.
List of TCAs
Those that preferentially inhibit the reuptake of serotonin (by at least 10 fold over norepinephrine) include:
- Clomipramine (Anafranil) (~200× selective for serotonin over norepinephrine reuptake)
- Imipramine (Tofranil, Janimine, Praminil)
Those that preferentially inhibit the reuptake of norepinephrine (by at least 10 fold over serotonin) include:
- Desipramine (Norpramin, Pertofrane)
- Dibenzepin‡ (Noveril, Victoril)
- Lofepramine§ (Lomont, Gamanil)
- Nortriptyline (Pamelor, Aventyl, Norpress)
- Protriptyline (Vivactil)
Whereas fairly balanced serotonin-norepinephrine reuptake inhibitors include:
- Amitriptyline (Tryptomer, Elavil, Endep)
- Amitriptylinoxide (Amioxid, Ambivalon, Equilibrin)
- Amoxapine (Asendin) – can be classed with the tetracyclic antidepressants (TeCAs) but more frequently classed with the secondary amine TCAs.
- Butriptyline† (Evadyne)
- Demexiptiline† (Deparon, Tinoran)
- Dimetacrine† (Istonil, Istonyl, Miroistonil)
- Dosulepin§ (Prothiaden)
- Doxepin (Adapin, Sinequan)
- Imipraminoxide† (Imiprex, Elepsin)
- Melitracen§ (Deanxit, Dixeran, Melixeran, Trausabun)
- Metapramine† (Timaxel)
- Nitroxazepine‡ (Sintamil)
- Noxiptiline‡ (Agedal, Elronon, Nogedal)
- Pipofezine‡ (Azafen/Azaphen)
- Propizepine† (Depressin, Vagran)
- Quinupramine† (Kevopril, Kinupril, Adeprim, Quinuprine)
and the following are TCAs that act via other mechanisms beside serotonin-norepinephrine reuptake inhibition:
- Amineptine‡ (Survector, Maneon, Directim) – norepinephrine-dopamine reuptake inhibitor
- Iprindole† (Prondol, Galatur, Tetran) – 5-HT2 receptor antagonist
- Opipramol‡ (Insidon, Pramolan, Ensidon, Oprimol) – σ receptor agonist
- Tianeptine‡ (Stablon, Coaxil, Tatinol) – indirect alteration of AMPA and NMDA glutamate receptor activity
- Trimipramine (Surmontil) – 5-HT2 receptor antagonist and moderate-potency serotonin reuptake inhibitor.
† indicates products that have been withdrawn from the market worldwide. ‡ indicates products that are not available in any country in of which English is an official language. § indicates products that are not available in the United States of America, but is available in other English-speaking countries such as Australia, Canada, United Kingdom, etc. Bolded names indicates products that are available in at least three countries where English is an official language.
- ^ Carson VB (2000). Mental health nursing: the nurse-patient journey W.B. Saunders. ISBN 978-0-7216-8053-8. pp. 423
- ^ a b A Guide to the Extrapyramidal Side-Effects of Antipsychotic Drugs, D. G. Cunningham Owens,http://assets.cambridge.org/97805216/33536/excerpt/9780521633536_excerpt.pdf
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- ^ a b c d Tatsumi M, Groshan K, Blakely RD, Richelson E. (1997). "Pharmacological profile of antidepressants and related compounds at human monoamine transporters". Eur J Pharmacol. 340 (2–3): 249–258.
- ^ Gillman PK (July 2007). "Tricyclic antidepressant pharmacology and therapeutic drug interactions updated".
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- ^ Branchek TA, Blackburn TP (2000). "5-ht6 receptors as emerging targets for drug discovery". Annual Review of Pharmacology and Toxicology 40: 319–34.
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- ^ Brian E. Cairns (1 September 2009). Peripheral Receptor Targets for Analgesia: Novel Approaches to Pain Management. John Wiley & Sons. pp. 66–68.
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External links
- Tricyclic Antidepressive Agents at the US National Library of Medicine Medical Subject Headings (MeSH)
- More information on TCAs


text:
2007-04-26, 23:25 | Link #22 |
sensei no pet
Join Date: Apr 2007
Location: Virginia, USA
That graph doesn't even reflect how many people are watching a show, much less whether they like it. It's just how often someone typed the name in an article or comment.
As they say, there are three kinds of lies... Blogs are killing the web. I spent all day looking for something decent about sola, and all I found were a ton of blog entries with nothing at all interesting in them. Just one after another episode summary or simply stating that the OP single was just released. I can get release info from the official site or outlets like cdjapan; I don't need some teenager in Saitoma to tell me when a DVD will become available. And if I want to know what happens in a TV show -- I'll watch the friggen' show. It's just repetitive mindless drivel. One blog (can't find the link to it now, oops) looked mildly interesting. Too bad I can't read Japanese. But he showed some photos of actual Nagasaki. I figured if I can't find pictures of Sola, I'll go look for pictures of the town. The stone bridge is pretty famous, it's called "Meganebashi". The church is based on Oura Catholic Church. The outside is only slightly similar, but the interior was reproduced pretty well (except for removing all the christian symbols) Glover Gardens, named after a British merchant, is a popular place to view the city from. The beginning of episode 1 shows a bit of it. And here's some gratuitous cloudservice for the soraphiles |
2007-04-26, 23:44 | Link #23 |
Welcome to my theory regarding blog entries on anime episodes being either uninformative or spun in a negative or positive light depending on the viewers preferences. Blogs and 2chan are among the most dangerous threats to my enjoyment of anime I can find. Both are a source for disinformation, and both have the ability to gather large numbers of people together to move and shake thing so to speak.
2007-04-28, 04:05 | Link #26 | |
Baka Gaijin :P
IT Support
Anyway, those pictures makes me want to visit the place now and bring a camera. XD And, no, not take pictures of skies, but maybe sunsets. :P |
2007-04-30, 09:06 | Link #33 | |
Lost in my dreams...
Join Date: Jun 2006
Age: 30
I will be really surprised if this doesn't end as one...
2007-04-30, 10:54 | Link #34 |
Martian diplomat
Erm...I'm not sure if I am supposed to ask for images here...but please hear out my problem...
Recently I have made a data DVD disc(my first DVD!) Consisting The whole series of Kanon, episode 1-3 or Lucky Star and episode 1-2 of sola. What I'd like to do is to make a cover image for the DVD box. But I don't know how to draw/edit pictures! Can anyone help me? |
2007-05-01, 11:24 | Link #37 | |
Anime Snark
Join Date: May 2006
Location: Singapore
Age: 34
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AUSTIN, Texas -- Golfsmith International, the world's largest specialty golf retailer, is rebranding its seven Boston-area Golf Town stores to the Golfsmith brand and customer experience. The move is part of the company's growth strategy, as it builds on its success becoming the region's largest golf retailer and integrates all of its U.S. stores under the Golfsmith umbrella.
Customers will continue to receive the same world-class service and expertise they have come to enjoy, with the best selection of golf's premier brands and an interactive 'try before you buy' player experience. Golf Town gift cards and other Golf Town programs will still be honored at Golfsmith locations.
To celebrate the rebranding, Golfsmith is hosting Grand Opening Events April 5-7 at all seven Boston-area stores. More than $15,000 in golf gear and prize giveaways will be awarded at the newly named Golfsmith locations. All customers who visit a Golfsmith store on Friday, Saturday or Sunday can register to win a $1,000 shopping spree and other prizes including drivers and fairway woods—with winners to be announced at close of business Sunday. Additionally, the first 100 people to visit each of the seven locations when stores open at 9:00 a.m. Saturday morning will receive a goody bag.
The newly renamed Golfsmith locations are:
• Avon, MA, 75 Stockwell Drive, Unit A
• Bellingham, MA, Charles River Center 251 A Hartford Avenue , Suite A-195
• Natick, MA, 1398 Worcester Street (Route 9)
• Northborough, MA, 6104 Shops Way
• Reading, MA, The Crossing at Walkers Brook, 40 Walkers Brook Drive
• Seekonk, MA, 45 Highland Avenue
• Watertown, MA, Arsenal Mall, 615 Arsenal Street, Unit B
All 150 former Golf Town employees at these stores have become Golfsmith employees.
"Folks in the Greater Boston area are passionate about golf, and have been great supporters of our Golf Town stores," said Sue Gove, President and CEO, Golfsmith International. "While the name on the store is changing, New Englanders will get the same world-class customer service and expertise when they shop at Golfsmith. We'll also bring exciting new customer offerings like advanced custom-fitting and pre-owned clubs to help golfers of all levels find the right gear."
Last year Golf Town and Golfsmith merged to create the world's largest specialty golf retail business - Golfsmith International. The company operates 157 golf retail stores across North America -100 in the U.S. (Golfsmith) and 57 in Canada (Golf Town). In addition to rebranding all Massachusetts locations, the Texas-based golf retailer is opening 12 new locations in 2013 in North America as part of an aggressive expansion plan of its retail footprint.
For More Information: New England customers can register on www.golfsmith.com for special offers and updates on the grand opening by signing up for "E-mail Offers" or learn more about the Boston area locations at www.golfsmith.com/boston.
Golfsmith International, based in Austin, TX, is the largest specialty golf retailer in the world operating Golfsmith stores in the U.S. and Golf Town stores in Canada and New England. The business operates as an integrated, multi-channel retailer, offering customers the convenience of shopping through any of its 150+ experiential retail locations or 24/7 shopping at its e-commerce sites - www.golfsmith.com and www.golftown.com. Golfsmith International offers extensive product selection of premier branded golf equipment as well as its proprietary products, club-making components and pre-owned clubs.
Media Contacts:
Lynn Luczkowski, L2 Communications 860-313-1426 or email@example.com
Aubrey Haznar, L2 Communications, 617-549-8792 or email@example.com
Chris Miller, Golfsmith, 512-821-4131 or email@example.com


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TQ8209 : West Hill Lift: steps at the top
taken 5 years ago, near to Hastings, East Sussex, Great Britain
West Hill Lift
Opened in 1891. It was originally powered by water, then oil 1924-1971, and electricity since 1971. The track length is 152m.
The West hill lift is a Victorian funicular cliff railway, which opened in 1891. Unlike the East Hill lift, the majority of the lift goes up through a 363ft (152m) tunnel The track length is 152m at an incline of 1in3. The entrance is just off the Western end of George Street.
It was originally powered by water, then oil 1924-1971, and electricity since 1971.
For more information Link
year taken
TIP: Click the map for Large scale mapping
Change to interactive Map >
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- Grid Square
- TQ8209, 3393 images (more nearby )
- Photographer
- Stephen Craven (find more nearby)
- Image classification?
- Supplemental image
- Date Taken
- Sunday, 12 August, 2012 (more nearby)
- Submitted
- Wednesday, 15 August, 2012
- Geographical Context
- Subject Location
OSGB36: TQ 8216 0957 [10m precision]
WGS84: 50:51.4172N 0:35.2067E - Camera Location
- View Direction
- South-southeast (about 157 degrees)
Looking for a postcode? Try this page
This page has been viewed about 18 times.
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Nancy Knapp Schilke, GP2 correspondent
DAMS' Italian driver notches third consecutive victory on Sakhir circuit
Davide Valsecchi did not let pole winner Giedo van der Garde pocket the win in today's Feature race on the Bahrain International Circuit as he took over the lead prior to the mandatory pitstops. The Italian racer for the DAMS team is now three for three at the Sakhir circuit, and he added to his points lead with the victory in the late afternoon. Fabio Leimer landed his first podium finish in the GP2 Series by finishing second, just ahead of van der Garde.
"Van der Garde was much better than me, but I could maintain his pace at the beginning, but after three or four laps I took a bit of confidence and I could close the gap. I overtook just before the pitstop. I knew I could still be quick on the second part of the race. We had a good pitstop. We had an early stop because we were not far enough to the others. I was afraid that I was too early, but since everyone did the same, we were both in the same conditions to finish the race. We could maintain the pace and the gap with Leimer," Valsecchi said.
It was an action-packed day for the GP2 drivers as they squeezed in the morning free practice before qualifying and after a short break, the contest for the first race of this weekend began. Van der Garde started from pole position with the points leader alongside. When the lights went out, the two rivals made the charge into the first turn on the 5.412 km circuit with Leimer right on their tail. The Dutchman won the first battle to take the lead followed closely by Valsecchi and Racing Engineering's Leimer.
Behind the top three, a charging Marcus Ericsson slipped into fourth with a stellar start from ninth on the grid. Following the iSport driver was Arden's Luiz Razia and Carlin's Rio Haryanto.
While van der Garde was pulling away from the eventual winner, he started to wear out his tires and ended up losing the gap he built and by lap eight, Valsecchi took over the lead. From that point on, the Italian was unstoppable, and kept the top spot after the pitstops. Unfortunately for the Dutch racer, Leimer was also able to catch him to take over second, and before van der Garde was able to pit for new tires, Razia and Carlin's Max Chilton were able to fly past him, after they managed to move ahead of Ericsson who also was struggling with his tires.
After the stop for new tires, the Swiss driver started to lay down hot laps to catch Valsecchi who simply turned fast laps in order to keep Leimer from challenging for the victory. Van der Garde moved back into third, and the top trio kept their positions for the rest of the race with no further threat to one another.
"Finally! I'm really happy because we deserved it in Malaysia and here last week but in the Feature race we did a small mistake with the strategy and at the end we were losing too much time and today finally everything was working well. I'm really happy," smiled Leimer.
Van der Garde expressed his disappointment by commenting, "I'm not happy. It's obvious that when you start first and you finish third it feels like losing and I do not like to lose. But, I have to be happy however because this is a good result still for the team, the best this season. I knew it was going to be hard on the tyres but so fast? I did not think it would happen like that. By lap 8, Valsecchi overtook me. I tried to hold him, but it was impossible. Same thing for Leimer. I had no tyre left. All you can do is survive."
Razia and Chilton were in their own world fighting for fourth while at the same time Ericsson slipped further down the order – he ended eighth which landed the Swede the pole for tomorrow's Sprint race. Razia took fourth followed by Chilton. Haryanto placed sixth.
DAMS' rookie Felipe Nasr did not have a great beginning but the Brazilian made up ground in the final laps to end 7th in a show stopper move when he passed both Esteban Gutierrez and Fabrizio Crestani in one single move.
Starting 20th on the grid was Johnny Cecotto for the Addax team who managed to move into seventh; in part due to an early pitstop but in the final laps, he lost ground and ended 10th after Nasr, Ericsson, and Rapax's Tom Dillmann who moved past the Venezuelan also.
Ericsson and Nasr will start on the front row in tomorrow's Sprint race; and due to the inverted grid for the top eight positions, Valsecchi will again have to contend with the drivers ahead of him for the standing start but he proved last Sunday, he is capable of getting around his competitors so he might leave Bahrain with four wins in four races!
However, the stewards handed out penalties after today's race and Nasr has now lost his front row start due to ignoring the marshals who were waving yellow flags! The Brazilian was not alone in having 20 seconds added to his finish time; Gonzalez also received the same penalty for the same infraction. Nasr will now start from 11th on the grid. Mexico's Gonzalez will start in 18th. Crestani, who did not finish the race today, received a five grid penalty for ignoring the yellow flags. Dillmann ended up moving into the top eight inverted pole slot for Sunday's race.


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McPherson made his remarks at the fifteenth commencement exercises at the School. He was awarded the Dean's Medal in recognition of his outstanding service and principled leadership across an impressive career in academia, business and public policy. Prior to joining A.P.L.U, McPherson was president of Michigan State University. He held senior executive positions with Bank of America, served as Deputy Secretary of the U.S. Treasury and as administrator of the U.S. Agency for International Development. He has also led various humanitarian organizations (click here for his biography).
In bringing his greetings to the graduates, Arthur L. Goldstein, chair of the IBS Board of Overseers noted they have "demonstrated personal resilience, unusual persistence, and an unwavering commitment to achieving the highest possible standards. These are traits that will serve you well throughout your careers."
Bruce Magid, dean of Brandeis IBS, remarked that as students working side-by-side from 43 countries, they "experienced first hand how to effectively manage across cultures." He added that as graduates, "you are now part of a truly global network of fellow alumni," sharing that former students serve in leadership positions in business, not-for-profit enterprises and international organizations across 80 countries.
The School awarded degrees in Master of Arts in International Economics and Finance, Master of Business Administration, Master of Science in Finance, Master of Science in International Economics and Finance, and Doctor of Philosophy in International Economics and Finance.


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oh that is one famous face – watch out Matt, she'll be after a model fee soon!!!
(great pic, by the way!!)
Barbie, it helps to be on first-name terms with her agent . I hope to get a discount on the model fee.
Gee, that would look great on a book….tee hee. One of my all-time fave pics Matt & the pic that convinced me to take up photography. We'll talk model fees when you come to Adelaide next month.
She's a very beautiful cat!!! At least she doesn't glare at the camera like some…
great shot Matt…also the framing really makes it …and those eyes!!!!!!
Beautiful photo, beautiful cat! Makes me want to pat her………….
Beautiful picture, and the use of black empty space is well thought out.
I love the way this pops up in the main pages all the time. I'ts like those eyes are watching me! Powerful stuff!
Loading more work by Matt Mawson...


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"Godbee acknowledged the statistics were "sobering."
But during his tenure, he said, there are 300 fewer officers and more guns on the street, which forces the department to juggle crime with fewer resources.
"The areas that have the most violent issues tie up a tremendous amount of resources," he said. "When the shootings go down, the officers are freed up."
As part of a move to boost police presence in neighborhoods, "virtual precincts" have been launched that move more officers into the streets.
But some residents worry there still aren't enough cops out, or say some areas do not receive as much attention."
So looking at the last line here and if Godbee admits the rise in crime is directly correlated to less cops then I guess we better stand by for the numbers to rise as the COD cuts 2500 jobs a percentage of which will be cops and firemen, the cuts cant all come from normal attrition....


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Posts filtered on Tag
Megan Fox and Brian Austin Green name their son
Megan Fox and Brian Austin Green have decided on a name for their son and it's Bodhi Ransom Green. Check out what it means.
Megan Fox pregnant
Actress Megan Fox is pregnant with her second child. The Transformers beauty gave birth to a son named Noah last September, and now she is expecting another baby with her husband, Brian Austin Green. Her representative tells the New York Post's gossip column Page Six, "I can confirm Megan is expecting her second child with […] …
Brian Austin Green signs up for 'Anger Management' role
Brian Austin Green has reportedly signed a deal to star opposite Charlie Sheen on "Anger Management."
Brian Austin Green's new comedy axed
Former "Beverly Hills, 90210″ star Brian Austin Green's new TV comedy has been cancelled just two months after its much-publicized launch. TBS bosses have axed "The Wedding Band," which also features "Lost" star Harold Perrineau, after th… …
Brian Austin Green: 'Reese Witherspoon helped keep our baby a secret'
Actor Brian Austin Green has publicly thanked Reese Witherspoon for inadvertently helping him keep his baby news a secret for almost two weeks. The proud dad reveals the media was so intent on getting information about Witherspoon's newborn, they ove… …
Brian Austin Green loses loan lawsuit
Actor Brian Austin Green has missed out on the chance to recoup $200,000 he allegedly loaned to his ex – because he waited too long to ask the courts to help him get it back. The former "Beverly Hills, 90210″ star and wife Megan Fox welcomed baby… …
Megan Fox welcomes a baby boy
Actress Megan Fox has become a first-time mom. The "Transformers" star and her husband, Brian Austin Green, secretly welcomed a baby boy last month, according to E! News. The name of the newborn has not been revealed. The couple wed in 2010 and bot… …


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A few weeks ago, we got wind of a pretty ill project featuring guys like Dabrye, Shigeto, and 14KT remixing joints off soul guitarist Dennis Coffey's self-titled album. And as promised, Coffey's label, Strut Records, has delivered the remix project, an eight-track EP called Outer Galaxies, for free.
We have a preview of what you can expect to hear on the EP below courtesy of Detroit producer 14KT. He got his mitts on "7th Galaxy" and asked fellow Motor City resident Jamall Bufford, formerly known as Buff1, to spit some bars on the funk-soul romp. It's what we like to call a proper remix -- you know, one that actually adds something new to the track. Everyone else on the EP does just the same, from Shigeto's space-y take on "All Your Goodies Are Gone" to Nick Speed's head-nodding version of "Space Traveller."
You can download the remix EP here and stream 14KT's remix of "7th Galaxy" below, where you can also peep the track listing.
01 7th Galaxy feat. Jamall Bufford (14KT remix)
02 I Bet You (version) (DeepSeeSoundSyetem mix)
03 All Your Goodies Are Gone feat. Mayer Hawthorne (Shigeto remix)
04 Plutonius (Recloose Re-Dub) Cuts by DJ CXL
05 Imported From Detroit (Magestik Legend, Produced by Astronote, made from samples of Knockabout)
06 Miss Millie feat. Kings Go Forth (Dabrye's Synthesized mix)
07 Space Traveller (Nick Speed remix)
08 Only Good For Ectomorph (Ectomorph appears courtesy of Interdimensional Transmissions)
Dennis Coffey - "7th Galaxy" f. Jamall Bufford (14KT remix) by AndrewMartin
Loney, Dear - Loney Dear Releasing New Album, 'Hall Music,' In October | Killer Mike Killer Mike's "Burn" Video No Longer Banned By BET |


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Slingo Supreme
Slingo Supreme
New power-ups and thousands of unique game possibilities await in this Slingtastic sequel!
Shockwave UNLIMITED members Sign in to play this game with no time limits at no additional cost.
Game Info & Requirements
Slingo Supreme
Slingo Supreme is the sequel packed with even more Slingtastic fun! Upload your own image to customize your look and play in new Supreme mode to unlock brand new power-ups like Reel Nudge and Instant Slingos. Combine power-ups to create more than 16,000 unique games or conquer dynamically generated Daily Challenges. Beat the Devil at his mini-games for a chance to double your score and then post your high scores for the world to see! The full version of Slingo Supreme features:- More than 16,000 possible games
- Unlimited daily challenges
- Lots of power-ups and mini-games
Seek and find fun meets Slingo excitement in Slingo Mystery: Who's Gold?.
Pus there's a new Slingo in town - be sure to check out Slingo Supreme 2!
Click on the spin button to start the slots. Click numbers on the board that correspond with the slot numbers to remove them. Remove as many numbers as you can.See in-game help for detailed instructions.
Minimum Requirements:
Windows Me/2000/XP/VistaMacintosh OS 9/OS X (online only)
1.0 GHz processor
32 MB video RAM
27 MB free disc space
SVGA Graphics Card
Online version requires Flash Player 9
Developed and Published by: Funkitron, Inc.


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Back in June I reviewed the Olympus mju 720 SW, a seven-megapixel compact camera designed for extreme durability - shockproof and waterproof to a depth of three metres. I had several reservations about it, not least its limited battery life, over-complicated control interface and disappointing picture quality, but I guess someone must have liked it because it won the prestigious EISA (European Imaging and Sound Association) award for the best pocket camera of 2006. I can only assume they didn't look at many others.
In light of this accolade, in October Olympus launched an updated version, the mju 725 SW. It looks almost identical, with the same tough industrial-looking steel body, complete with exposed Allen bolt heads. These struck me as a bit of a cosmetic pretence the first time around, so in a spirit of inquiry I undid the three on the front panel just to make sure they were real bolts. In fact one of them was a fake, but the other two held the front inset panel in place. The camera comes in three colour schemes (the Titanium version you see here, plus Deep Blue and Cherry Red) with only this inset panel being of the different colour.
The similarity between the two models even extends to the retail price. The mju 720 SW is available online for around £220, while the best price for the new 725 SW is £223.
The only real difference between the 720 and its successor is an improvement to its already impressive durability. Where the 720 was waterproof to a depth of three metres, the 725 is waterproof to five metres, a whole extra 1/5th of an atmosphere of pressure, which I'm sure will make a huge difference.
In the official description of the mju 725 the shock-proofing is rated to "MIL Standard (MIL-STD 810F)" a complex and highly specific set of testing criteria published by the US military. I've had a look at the relevant section and apparently it means that the mju 725 SW can withstand momentary shocks of at least 1,000 G, about fifty times what the human body can withstand. It's very impressive, and it's certainly reassuring to know that the camera can survive the kind of impact that would turn its owner into jam, but I'm not sure it's actually any better than the mju 720 in this respect.
More information -
Trusted Reviews is part of the Time Inc. (UK) Ltd Technology Network
Get TrustedReviews' award-winning reviews and advice delivered to your inbox for free!


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Following a tease by director Marc Webb himself last week, we now have your exclusive first look at the costume that will be featured in next summer's The Amazing Spider-Man 2. Check it out below!
As Webb promised last November, the costume features much bigger eyes and a number of alterations to color and texture throughout. This is quite arguably the closest any of the films have come to matching the design from the comics, especially Mark Bagley's take in Ultimate Spider-Man. A good visual comparison is this photo from last year's The Amazing Spider-Man, featuring Spidey in a similar pose.
In The Amazing Spider-Man 2, Peter Parker (Andrew Garfield) finds, life is busy – between taking out the bad guys as Spider-Man and spending time with the person he loves, Gwen (Emma Stone), high school graduation can't come quickly enough. Peter hasn't forgotten about the promise he made to Gwen's father to protect her by staying away – but that's a promise he just can't keep. Things will change for Peter when a new villain, Electro (Jamie Foxx), emerges, an old friend, Harry Osborn (Dane DeHaan), returns, and Peter uncovers new clues about his past.
Also starring Martin Sheen, Shailene Woodley, Paul Giammatti, Felicity Jones and Colm Feore, The Amazing Spider-Man 2 hits theaters May 2, 2014.
(via ComingSoon.net)


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PROVIDENCE – Pawtucket-based toymaker Hasbro Inc. was granted up to a $1.63 million tax break by the R.I. Economic Development Corporation on Monday if it creates 281 new full-time jobs over the next three years.
Hasbro executives have told state officials that they've outgrown offices in Pawtucket and East Providence, and they were interested in establishing another location in Providence. Hasbro hasn't identified possible sites.
The EDC board approved "project status" for Hasbro to renovate or construct and furnish the offices, which the company estimated would cost about $24 million. The designation gives Hasbro a sales-tax exemption for purchasing building materials and other items.
The tax break is based on how many "higher-paying" positions – jobs that pay more than $36,691 annually, or 105 percent of the median wage – will be created.
Hasbro said it will create 284 jobs, 281 of which will meet the criteria. Salaries for the new positions will range between $22,500 and $157,558. State officials have estimated the 281 qualified jobs will add $1.63 million in income tax revenue for the state over the first three years, the amount of the tax break.
Gov. Lincoln D. Chafee, who serves as EDC chairman, previously has expressed concern about approving tax breaks for individual businesses, but he supported the move for Hasbro.
Nice. Mr. PotatoHead rules Rogue Island. He should be the governor. What do you have to lose?


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Sony has a double dose of good news for gamers this morning; one of the announcements is good, and the other is even better. First off, Uncharted 3 has officially gone gold. The game is done, finished, ready to roll and off to the presses for public consumption. There is nothing short of a major natural disaster (knock on wood) that will prevent the game from launching on November 1, 2011.
That is the good news, the better news is that Uncharted 3 will contain early access vouchers for the upcoming multiplayer beta test of Starhawk. Sony is planning a public beta of the upcoming game in early 2012 but buying a retail copy of Uncharted 3 will get you a code to get early access to the beta program.
That seems like a nice bonus to us even though we aren't sure that there was any more incentive needed to advertise Uncharted 3 other than the fact that it is, well, Uncharted 3.


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Hey Everyone,
I'm happy to bring you this first installment of Aquarium Care FAQ – a new theSmileyFish series. I've been receiving a lot of emails from people who've asked for help with their new aquariums. So, I've decided to share both some of the most frequently asked aquarium care questions and the answers with the general public.
Yes; untreated tap water is harmful to all fish. Tap water contains chlorine, chloramines, phosphate, heavy metals, and other harmful impurities, all of which water utility companies add to drinking water to make it "safe" for human consumption.
While the human body can withstand these sanitizing poisons added to tap water, tropical fish cannot!
That's partly because tropical fish have extremely thin skin which will burn when exposed to chlorine and chloramines.
This is why all tap water intended for aquarium use must be treated with something called water conditioner before being added to the aquarium. There are a variety of water conditioners available on the market and they will all effectively remove chlorine and chloramines.
Most water conditioners need a few minutes to take effect (some need more). When adding fresh water to an aquarium that's already set up (into one that already has fish in it), I put the tap water into a clean bucket, then add the water conditioner, swirl the water around with my hand to ensure proper mixing, and then wait a few minutes before adding that water into the aquarium.
It's important to note, however, that water conditioner will not remove phosphate from your tap water.
Phosphate is a compound that's readily absorbed by problem algae. Phosphate, in effect, promotes problem algae blooms in the home aquarium.
So, if you want to go the extra mile by removing not only chlorine and chloramines, but also phosphate, you can opt to use RO (reverse osmosis) water for your aquarium.
RO water is pure H2O, so you don't have to add water conditioner to RO water.
You can usually find Ro water at your neighborhood grocery store or even at your local aquarium shop …or you can make it yourself!
If you want to make your own RO water, you'll need something called a RO unit – it's basically a machine that uses a superfine semi-permeable membrane to physically separate "dirty" water from pure H2O.
I bought my RO unit for $240.00 (the picture above shows mine in its temporary bathroom setting). Yes; that was a bit of an investment, but the machine has paid for itself not only in financial terms, but also by cutting down potential maintenance caused by problem algae growth. In fact, when I first started using RO water, algae growth decreased by a whopping 90% and I haven't seen any cyanobacteria (blue green algae) in ages! I've experienced no problems with the unit after years of operation.
Also, keep in mind that RO water is pure H2O. That means that it's extremely soft and that it, therefore, cannot sustain high pH levels (for a detailed discussion of hardness/softness, buffering capacity, and pH see pages 30-32 of the Aquarium Care Book).
So, if you use RO water, and only RO water, you'll have to add trace element solutions to compensate for the loss of beneficial compounds lost during the reverse osmosis process. Adding such solutions will also solve the potentially low pH problem.
Whether you use water conditioner or buy or make RO water, remember that the chlorine and chloramines in tap-water will quickly kill your tropical fish. So, tap-water always needs to be processed by one of the two ways outlined above.
One person commented on "Aquarium FAQ: "Is Tap Water Okay For My Fish?""
Feel free to join the conversation and leave a comment as well.
I always put tap water into my tropical fish tank but I boil it in a huge pot and add tonic salts. and I've been doing this for 2 years now, and my fish seem happy swimming around except one died from popeye. but i think my fish are hardy because they are neon tetras and a black fish with a yellow tipped tail that eats algae and reproduces every day (lol). I also have 2 plecos, 2 snails, some danii's and mixed breeds (lol). After getting some fish they all mated and had oddly mixed babies (lol).


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Brisa Cocina's Salchi-Burger
I had a salchi-burger at Brisa Cocina Mexicana on San Felipe yesterday. What a lovely example of restaurant fare inspired by street food. The hamburger was topped with a thin slice of ham, jalapeño sausage slices, and melted cheese, and served on a toasted bun spread with refried beans and spicy mayo. Condiments included tomato, sliced onion, lettuce and avocado.
It was sort of a cross between a hamburguesa estilo Monterrey and one of those wacky Los Angeles combo burgers John T. Edge wrote about in the chapter titled "Going for Baroque in Los Angeles" in his book Hamburgers and Fries. Hamburgers are topped with chorizo, pastrami, chili con carne and much more in L.A. Edge described one "double puck" hockey burger topped with crossed "hot dog hockey sticks."
Among L.A.'s sausage-topped burgers is Pink's Poli-Bacon Chili Cheeseburger, a cheeseburger topped with grilled Polish sausage that can be ordered with an extra burger patty. Pink's hot dogs in Los Angeles started out as pushcart selling hot dogs and tamales. This year Pink's celebrated its 70th anniversary.
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RG 062:105, Town of Old LymeInventory of RecordsFinding aid prepared by Connecticut State Library staff.Copyright � 2012 by the Connecticut State Library
Historical NoteThe town of Old Lyme was established in May 1855 fas South Lyme. It was set off from the town of Lyme. The name was changed to Old Lyme in 1857. Return to the Table of Contents Scope and ContentsConsists of one item, a chart showing school statistics for Old Lyme, Connecticut, 1855-1930. Return to the Table of Contents RestrictionsRestrictions on AccessThese records are stored at an off-site facility and therefore may not be available on a same-day basis. See the Rules and Procedures for Researchers Using Archival Records and Secured Collections policy. Restrictions on UseSee the Reproduction and Publications of State Library Collections policy. Return to the Table of Contents Index TermsSubjects:Schools -- Connecticut -- Old Lyme -- Statistics
Places:Old Lyme (Conn.)
Document Types:Charts (graphic documents)
Return to the Table of Contents Container List


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Related Suppliers
Xspect Solutions (Wixom, Michigan) has introduced a new rental program for X-Orbit CMMs produced in the United States. Keith Mills, president of Xspect Solutions, says the program was created to help manufacturers that are struggling to justify new capital equipment purchases as program schedules and quantities for parts suppliers shrink.
Through the Rent2Measure program, manufacturers can use a Wenzel X-Orbit CMM with a Renishaw PH10T/TP20 probe on their shop floors for 6 to 36 months. Additional features include a suite of OpenDMIS software, an MCR20 styli change rack, installation service and a CMM calibration program as well as 3 days of training for two operators. The company also includes the CMM XtraCare package, which covers virtually all breakdowns and provides software upgrades, an on-site Dell PC warranty, a Renishaw probing warranty and application and software support.
Typical cost to rent a CMM is $2,975 per month. The program requires no long-term purchase commitment, although renters can apply 65 percent of payments to offset the purchase price of the CMM at any point during the rental period.