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Buffalo Chicken Shepherd's Pie takes a traditional shepherd's pie and completely transforms it into something new and way more delicious! The meat and gravy filling have spicy Buffalo chicken, and a topping of mashed sweet potatoes and blue cheese finish the top. This is a great way to enjoy a gluten free St. Patrick's Day!
I'm guessing you are right about the Irish not using Frank's Hot Sauce but in my humble opinion, most dishes can be improved with some chili peppers or hot sauce. I love the spicy flavors you've got going on here, Brianne, especially with the sweet potatoes. Lovely variation on an old favorite of mine!
Stacy recently posted…Bailey's Irish Cream Muffins for #MuffinMonday -
Oh, wow. This looks AMAZING. My daughter is so spice sensitive that she won't eat buffalo anything… so I'm putting this at the top of the list of things to make when she won't be home. I must have it now!
Pam recently posted…Shortcut Chicken and Dumplings -
Oh! I also put Frank's Red Hot on everything. It improves all foods instantly. Loving the sweet potatoes! So glad this is part of this week's meal plan!
Heather @ Sugar Dish Me recently posted…Sun Dried Tomato and Asparagus Pizza -
This look amazing! A few of us in the family LOVE buffalo anything 🙂 Thanks for sharing
Wendy @ http://www.mamasblogcentral.com recently posted…How to make your own Sweet Heat Pickles -
well yum yum YUM to that!
the cape on the corner recently posted…Because there's a spring vignette party -
Just made this after work and it was a hit! Thanks!!!
Brianne, I love this unique take on Sheperd's Pie – my hubby would love this! Thanks so much for sharing at Best of the Weekend and pinning to our party board. Hope you have a happy Sunday and a wonderful week!
Cindy Eikenberg recently posted…Best of the Weekend!


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T-Mobile Tests MediaFLO Too
Nov 22, 2006, 8:43 PM by (staff)
The President of MediaFLO, Gina Lombardi, has revealed that the company is in trials with T-Mobile for its mobile TV service. Because MediaFLO is a Qualcomm-owned company, it has been assumed it would be the choice of CDMA carriers. Sprint is already testing the service under the brand VUE. However since digital TV is a different technology from cellular transmissions, it is open to GSM carriers as well. T-Mobile has not revealed the extent of the trials, nor have they announced which technology the they will ultimately choose for digital TV. T-Mobile has also been a test partner of DVB-H provider Modeo.
T_mob is coming UP!!!!!!
Verizon in trouble? Something tells me with 57 customers and the fastest-growing subscriber base (more adds last quarter than anyone) that they have nothing to worry about. Their data is a full year ahead of Cingular...and who is T-Mobile?

subset: commoncrawl


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By Gina Carey. February 03, 2014 | See Comments
Portosystemic shunt is a condition in which a dog or cat's fresh blood supply bypasses the liver. Liver shunts that form before a pet is born are called congenital liver shunts, but cats and dogs prone to liver disease and high blood pressure within the liver can develop acquired liver shunts later in life. Read on to learn more about how liver shunts are diagnosed and treated in dogs and cats.
A liver shunt is a blood vessel that bypasses fresh blood flow through the liver, and instead carries blood around this vital organ. Liver shunts that develop outside the liver are called extrahepatic. Intrahepatic liver shunts take place when a blood vessel inside the liver called the portal vein doesn't seal properly at birth. Both cases result in the liver being unable to filter toxins before they are absorbed.
There are a number of tests that your vet will perform to diagnose your cat or dog with liver shunts. Symptoms of liver shunts include seizures, diarrhea, vomiting, disorientation, stupor, lethargy, and kidney stones. Young pets may appear underdeveloped, resist gaining weight, and have low muscle tone. These symptoms are similar to many other pet disorders, so a combination of tests may be needed to narrow down the exact cause. After doing a thorough physical, your vet may perform blood work to measure bile acids. Other tests used to diagnose liver shunts include ultrasounds, CT scans, MRIs, portography, and exploratory surgery.
Surgery is the most effective way to treat extrahepatic liver shunts. During this procedure, a device called the ameroid constrictor is used to close the shunt. Intrahepatic liver shunts are more difficult to correct surgically and often have more post-surgical complications than extrahepatic shunts.
When surgery is not an option, veterinarians can suggest a few treatment options that will help stabilize the condition, including a change in diet and administration of lactulose and antibiotics.
Congenital liver shunt develops in utero, and cannot be prevented after a pet is born. It is unclear how pets inherit liver shunts, but veterinarians recommend that animals with congenital liver shunts not be bred. Acquired liver shunt occurs when there is high blood pressure in the liver, so early prevention is related to managing and correcting diseases like cirrhosis that cause those shunts to form.
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With thousands and thousands of deer being harvested every fall during hunting season, many of you are looking for new ways to prepare the pounds and pounds of venison in your freezers. In colonial times, venison was the main source of meat for the dinner table. Early settlers had few domesticated animals and the ones they had were rarely used for meat. Women had many ways of preparing and preserving wild game. |
Today we serve beef, pork, veal, seafood or poultry daily and some of us really don't want to cook venison. We've either heard about or had first hand experience with deer meat that was dry and tough and had an unpleasant flavor. Preparing good venison starts with the hunter. Preparation begins immediately after the deer is shot and how it's done plays a big part in whether the venison is tasty and delicious or gamey and chewy. Prompt and careful field dressing, chilling and refrigeration are very important. See the links below this article for information on proper field dressing, refrigeration, skinning, cutting and processing. Get ideas on wrapping, freezing, storing and other tips for deer hunters. Venison is naturally lean. It's low in calories, fat and cholesterol.... Venison Cooking Tips Venison Remedies Venison Recipes From Lori Holuta, of CocoaJava.Com... To prepare a fantastic tasting Venison Roast that's so tender it falls apart... To prepare venison steak.... More venison recipes from Lori.... Thank You for the wonderful recipes, Lori! More Venison Recipes From basic recipes for home and camp to preparing and presenting venison for elegant dining, this book has over 700 venison recipes for steaks, chops, roasts, ribs, chilies, stews, stroganoffs, meat loaves, burgers, and more. Waring Professional Food Slicer Waring Electric Meat Grinder
A 3 oz. serving of venison loin has only about 139 calories, 62 grams of cholesterol and 5 grams of fat. A comparable cut of beef has 223 calories, 77 grams of cholesterol and 13 grams of fat.
before serving to give the juices time to distribute evenly.
If your venison has a strong and unpleasant taste....
Vinegar, wine vinegar and wine
Salad dressings such as French or Italian
Tomato sauce, tomato soup, stewed tomatoes and tomato juice
Orange, lemon and grapefruit juice
(Tomato acids tenderize the meat nicely.)To easily slice venison bologna....
This slicer features a 7.5" stainless steel cutting blade with a serrated edge and a knob that adjusts your slices from 1/32-in. to 1/2-in. for meat, breads, firm cheese and more. As an added safety feature, sturdy food guides prevent the blade from coming into contact with fingers.Quickly chop and grind your venison into burger....
This grinder from Waring is professional in design, made of brushed stainless steel with a die-cast metal hopper. It has a powerful, 150-watt motor with three cutting plates (Fine, Medium or Coarse) and includes two attachments for making your own sausage. A single On/Off switch makes operating it simple; a Reverse function repositions ingredients that might become trapped while grinding. It grinds approx. 2.5-lbs. per minute.


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Bernard M. Baruch Papers 1701-1965 (mostly 1917-1965)
Search Tips | How to Browse this CollectionSubseries 2B: American Commission to Negotiate Peace at the Versailles Conference
11.51 linear feet, 64 volumes and 2 boxes
This collection is stored at Mudd Manuscript Library.
Requests will be delivered to Public Policy Papers, MUDD Reading Room .
Collection Creator: Baruch, Bernard M. (Bernard Mannes), 1870-1965..
Dates: 1918-1920.
Extent: 11.51 linear feet, 64 volumes and 2 boxes
Languages: English.
Access Restrictions
The collection is open for research.
This subseries documents Baruchs involvement with the activities of the American Commission to Negotiate Peace, a commission appointed by President Woodrow Wilson to negotiate formal treaties following World War I, January 1, 1918-December 9, 1919. It includes the text of the treaty with Germany and related documents, meeting minutes, bulletins, committee files, subject files, and reports.
The files are further subdivided into the Peace Conference Section, the Supreme Economic Council, the Reparation and Economic Section, Reports, and Oversize Material. The Peace Conference Section are bound in a set of 37 volumes and two supplementary volumes. The Supreme Economic Council section is bound in a set of eight volumes. The Reparation and Economic Section is bound in a set of 20 volumes. Related reports are filed in one box at the end of the subseries, and related oversize material is filed in a map case..
Preferred Citation
Subseries 2B: American Commission to Negotiate Peace at the Versailles Conference; 1918-1920; Bernard M. Baruch Papers, Public Policy Papers, Department of Rare Books and Special Collections, Princeton University Library.
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You'd probably need a 10.5 in the Katahdins. Maybe an 11.
YMMV, as I fit into a 10.5 in the Iron Rangers, and my Katahdin 10.5's fit equally as well.
Both were a tad narrow to begin with, but eased out during the break in period.
For most shoes I wear a size 11.
Definitely true to size.
I'm measured as 8D (with thinner socks), and I wear 8D in Allen Edmonds, 7.5 D in Clarks Desert Boots, and 7D in Red Wing Iron Rangers. I had a pair of Katahdins in 8D and they fit perfectly. Still had a just a little bit of wiggle room.


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Chronic obstructive pulmonary disease phenotype desaturator with hypoxic vascular remodelling and pulmonary hypertension obtained by cluster analysis
- Domenico Maurizio Toraldo1Email author,
- Mauro Minelli2,
- Francesco De Nuccio3 and
- Giuseppe Nicolardi3
© Toraldo et al.; licensee BioMed Central Ltd. 2012
Received: 9 July 2012
Accepted: 25 October 2012
Published: 5 November 2012
Significant heterogeneity of clinical presentation and disease progression exists within chronic obstructive pulmonary disease (COPD). This article discusses and refines the concept of desaturator phenotypes in COPD with pulmonary hypertension (PH) obtained by cluster analysis and presents a pattern of phenotypic markers that could be used as a framework for future diagnosis and research. Nocturnal oxygen desaturation results in sleep disturbances which predispose to nocturnal cardiac dysrhythmias, PH and possibly nocturnal death, particularly during acute exacerbations. We assume that in patients with COPD at least two factors play a role in PH: the severity of pulmonary impairment, and the severity of systemic nocturnal hypoxaemia due to reduced pulmonary functions. Establishing a common language for future research will facilitate our understanding and management of such a disease. This knowledge could lead to different pharmacological treatments and other interventions directed at specific phenotypic groups.
Chronic obstructive pulmonary disease Desaturator Nocturnal hypoxaemia Phenotypes Pulmonary hypertensionBackground
Introduction to COPD and its prevalence across the world
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lungs to noxious particles or gases [1]. The World Health Organization (WHO) has described COPD as a global epidemic, and it is estimated that about 64 million people worldwide are affected by this disease. In 2005 more than 3 million people died because of COPD, accounting for 5% of all deaths worldwide that year. It is estimated that the total number of deaths due to COPD is likely to increase by over 30% in the next 10 years if nothing is done to reduce the risks, particularly those resulting from exposure to tobacco smoke [2]. No effective treatment for COPD exists to date and research into new therapies will be essential if this disease is to be managed in the future.
In recent years, it has emerged that COPD is a complex disease with multiple clinical manifestations and that COPD subjects cannot be described by the severity of airflow limitation alone. Many other independent predictors of clinical outcome have been identified, including worsening dyspnoea, frequency and severity of exacerbations, malnutrition, depression and health-related quality of life (HRQoL) impairment. Therefore, one topic of growing interest in the scientific community, highlighted by studies such as the ECLIPSE [3], is the identification of different phenotypic subgroups of patients. It is possible that the different phenotypes are characterized by different etiopathogenetic mechanisms and that patients in different subgroups will respond differently to drug therapy.
This clinical commentary focuses on COPD and nocturnal hypoxaemia, which can be the cause of pulmonary hypertension (PH). This condition may represent a new phenotype of COPD the desaturator characterized by cluster analysis, a new method of statistical analysis. Cluster analysis is used as artificial intelligence in such diverse fields: biology, medicine, psychology, and business. It entails grouping similar objects into distinct, mutually exclusive subsets referred to as clusters. Elements within a cluster share a high degree of "natural association", whereas the clusters are relatively distinct from one another. This procedure has recently been used in clinical medicine to classify patients and their data.
We assume that in patients with COPD and PH at least two factors play a role: the severity of pulmonary impairment, and the severity of nocturnal hypoxemia due to reduced pulmonary functions. The severity of COPD also influences the degree of oxygen desaturation and the lower the FEV1/FVC ratio, the more likely is the possibility of significant desaturation during sleep.
Scientific knowledge on the issue
- 1)
Epidemiological data suggest that nocturnal symptoms and nocturnal oxygen desaturation with symptomatic sleep disturbance are common and may occur in more than 76% of patients with COPD.
- 2)
COPD patients with a T90 of ≥ 30%, a mean nocturnal arterial oxygen saturation (SatO2) of ≤ 90% and a minimum (nadir) SatO2 of 85% have been defined as desaturators (D) and the others as non-desaturators (ND).
- 3)
The worsening of nocturnal hypoxaemia is due to a variable combination of alveolar hypoventilation and ventilation-perfusion mismatching.
- 4)
Nocturnal oxygen desaturation appears to contribute to the development of pulmonary hypertension (PH). PH is defined as an increase in mean pulmonary arterial pressure (MPAP) ≥ 25 mmHg at rest as assessed by right heart catheterization (RCH).
- 5)
Poor correlation between lung function parameters and pulmonary arterial pressure (PAP) suggests that factors other than airway obstruction and loss of alveolar surface area may play a role in PH.
Main text
The complexity of COPD/COPD as a systemic disease
The recognition of COPD as a systemic disease has developed in recent years [4]. Comorbidities such as chronic heart failure, cardiovascular disease, depression, diabetes, muscle wasting, weight loss, lung cancer, and osteoporosis can frequently be found in patients with COPD and are considered to be part of the commonly prevalent non-pulmonary sequelae of the disease [5, 6]. Systemic inflammation is considered a hallmark of COPD and may be one of the key mechanisms responsible for the increased rate of comorbidities [7].
Even though more than 75% of patients with COPD report poor sleep quality, night-time symptoms and sleep disturbances in COPD are generally not considered in the clinical management of the disease [8]. For instance, the most recent Global Initiative for Chronic Obstructive Lung Disease guidelines (GOLD 2011) do not mention sleep disturbance as a target for therapeutic intervention, and no or very limited specific guidance is offered on appropriate management strategies or pharmacological interventions for patients with COPD who report alterations in sleep. In fact, the nature and cause of disturbed sleep in COPD has been poorly characterized so far, and the long-term clinical consequences of sleep disturbance in COPD have yet to be explored.
In general, COPD-associated PH is mild and develops in patients with a severely impaired pulmonary function. PH may develop slowly in the natural course of COPD. The main cause is hypoxic vasoconstriction of small pulmonary arterioles that subsequently undergo structural changes, reducing their elasticity and cross-sectional surface area [9]. Nocturnal hypoxaemia appears to contribute to the development of PH, even in the absence of significant awake hypoxaemia [10].
Sleep disturbance and nocturnal oxygen desaturation
Sleep plays a key role in COPD, although the degree of nocturnal oxygen desaturation during sleep varies from patient to patient. Usually, in patients with COPD, there is decreased sleep efficiency, decreased total sleep time, and increased wake time after initial sleep onset. In addition, there is decreased Rapid Eye Movement (REM) sleep and decreased stages III and IV sleep. These changes in sleep are more pronounced in elderly patients with COPD.
Nocturnal hypoventilation has been demonstrated in COPD during REM sleep, with associated oxygen desaturation [15]. A correlation has been shown between the awake arterial oxygen tension (measured as the partial pressure of oxygen in arterial blood (PaO2) in mmHg) and nocturnal arterial oxygen desaturation (measured as the percentage of oxygen saturation in arterial blood (SatO2), particularly during REM sleep; in addition, the nocturnal desaturation is accompanied by hypercapnia [16, 17]. The contribution of respiratory muscle hypotonia to sleep-related breathing is reduced in sleep, particularly during REM. This contributes to a worsening of ventilation-perfusion mismatching, which also aggravates hypoxaemia and hypercapnia. The consequences of nocturnal hypoxaemia (and hypercapnia) in patients with COPD may include acute events, such as altered sleep structure, arrhythmias and increased risk of cardiovascular and cerebrovascular disease [18].
Hypoxemia and COPD-associated pulmonary hypertension
The exact prevalence of PH in patients with COPD is unclear [19], although it is more common and more severe in patients with advanced COPD who show severe long-term hypoxaemia. Even though PH is mild to moderate in most COPD patients, it can markedly worsen during acute exacerbations, sleep and physical exercise, as shown in a study by Kessler et al. [20] in which 25% of COPD patients developed PH during physical activity. These acute increases in PH can facilitate the development of right heart failure (RHF), so it is important to diagnose PH as soon as possible in high-risk COPD patients. The diagnosis of PH in COPD patients is difficult. PH should be suspected in patients with COPD and declining functional capacity or increasing shortness of breath in the presence of stable airflow obstruction and the lack of an alternative explanation (eg. interstitial lung disease, obstructive sleep apnea, or other comorbidities).
The published studies differ not only in their definition of PH but also in the conditions under which PH is reported (rest, exercise and exacerbation). According to the European Society of Cardiology and the European Respiratory Society, PH is defined as an increase in mean pulmonary arterial pressure (MPAP) ≥ 25 mmHg at rest as assessed by right heart catheterization (RHC) [21]. This is the definition adhered to by the authors of this commentary. Nocturnal oxygen desaturation seems to contribute to the development of PH, even in the absence of significant daytime hypoxemia [22]. REM-associated falls in SatO2 are associated with increases in pulmonary arterial pressure (PAP) which can be reversed by supplemental oxygen, although most COPD patients with sustained PH are also hypoxaemic during the daytime. Various arrhythmias are also reported during episodes of nocturnal desaturation [23]. These consequences might help to explain why nocturnal oxygen desaturation is a marker of increased mortality, and why COPD patients are reported to die more frequently at night than expected [24]. COPD patients have increased circulating markers of systemic inflammation when compared with healthy controls [25]. Systemic inflammation stimulates pulmonary vasculature and promotes the development of skeletal muscle dysfunction and osteopenia [26]. The pulmonary vasculature of COPD patients with PH is characterized by luminal narrowing due to thickening of the intima, along with arteriolar muscularization.
Another major contributor to the development of PH in COPD patients is nocturnal hypoxia-induced remodelling of the pulmonary vasculature [27]. Hypoxia-induced pulmonary vasoconstriction is a protective response that keeps the ventilation-perfusion ratio optimal by shunting blood away from hypoxemic areas. The traditional hypoxic model of PH is based on the hypothesis that chronic hypoxia initiates vascular remodelling leading to permanent changes in pulmonary vasculature [28]. Studies performed in vitro have elucidated the mechanisms underlying hypoxia-driven vascular changes [29, 30]. Barbera et al. [31] evaluated COPD patients undergoing lung resection and demonstrated that vascular changes contribute to vascular remodelling and may have an effect on vascular dynamics leading to PH. Nocturnal hypoxia may also induce endothelial cells to release proliferating cytokines leading to cellular hypertrophy in the vessel wall and an increase in the production of extracellular matrix proteins [32]. Although one recent work [33] has shown that there is no correlation between the severity of airway obstruction hypoxemia and PH, there seems to be a large body of evidence to support the role of hypoxemia-induced remodelling of pulmonary vasculature in the development of PH.
In some studies [34–36], COPD patients have been categorized as desaturators (D) or non-desaturators (ND) based on the levels of oxygen desaturation defined by certain parameters, namely SatO2 and T90. Nocturnal hypoxemia has been defined as a SatO2 of ≤ 90% for at least 5 min with a nadir SatO2 of ≤ 85%. The percentage of nocturnal total recording time (TRT) has been defined as "time spent in bed – sleep latency + intra-sleep wakefulness". TRT with a SatO2 of ≤ 90% has been defined as the T90 percentage. The minimal TRT required for a satisfactory analysis of nocturnal recordings was 2 hours. COPD patients with a T90 of ≥ 30% and a nadir SatO2 of 85% have been defined as D patients and the others as ND patients. D patients are more at risk of respiratory complications such as cardiovascular disease, hospitalization, and ultimately death [37].
In this commentary, the authors describe their own studies in which cluster analysis was used to redefine the COPD D phenotype and show that daytime clinical variables can be predictive of the severity of nocturnal oxygen desaturation in D patients [34]. Cluster analysis refers to the use of various algorithms to place individuals into different groups or "clusters", based on multiple measured parameters, such that individuals in the same cluster are more similar to each other than to those in different clusters. In 29 out of 51 consecutive COPD outpatients [22] with mild daytime hypoxemia (PaO2 60–70 mmHg), cluster analysis identified a pattern of daytime clinical variables that distinguished D patients from ND patients. Considering all patients, the values of T90, MPAP at rest, partial pressure of CO2 in the blood (PaCO2), nadir nocturnal SatO2, mean nocturnal SatO2 level, predicted total lung capacity (TLC), baseline awake SatO2 level, predicted vital capacity (VC), and body mass index (BMI) had a bimodal distribution. The variables examined in the study did not differ between men and women. Rather than using T90 alone, the study showed that D patients may be identified by a pattern of T90 (30.08%–45.1%, P = 0.0001), MPAP (33.1 ± 0.7 mmHg, P = 0.0006), and PaCO2(35.0–57.9 mmHg, p = 0.0005) values, with the latter two variables being predictors of the severity of nocturnal oxygen desaturation.
In contrast, Chaouat and co-workers [39] showed that isolated nocturnal hypoxaemia does not induce permanent PH, nor leads to worsening levels of daytime blood gases. In fact, it is now recognized that the development of PH due to chronic nocturnal hypoxaemia requires a certain threshold of severity and duration. It is likely that this threshold was not reached during the episodes of nocturnal hypoxaemia in D patients this study.
Patients with COPD frequently experience nocturnal oxygen desaturation episodes, leading to nocturnal hypoxemia. Chronic nocturnal hypoxemia contributes to the development of an adverse sequelae of COPD, including PH, skeletal muscle dysfunction, and cardiovascular disease. Subsequently, the concept of chronic inflammation as one of the key factors involved in pulmonary vascular remodeling has emerged. We propose that data from large clinical trials should be re-analyzed using cluster analysis in order to classify patients according to their clinical characteristics at study entry. However, the clinical application of cluster analysis will depend on developing diagnostic criteria to allow new individuals to be allocated to pre-established clusters. Only time will tell if this new approach is effective in the prediction or diagnosis of COPD-associated diseases and in their prevention or treatment respectively.
Chronic obstructive pulmonary disease
Pulmonary hypertension
- HRQoL:
Health-related quality of life
- SatO2:
Arterial oxygen saturation
Mean pulmonary arterial pressure
Right heart catheterization
Pulmonary arterial pressure
Functional residual capacity
- PaO2:
Partial pressure of oxygen in arterial blood
Right heart failure
Total recording time
- PaCO2:
Partial pressure of CO2 in arterial blood
Total lung capacity
Vital capacity
Body mass index
Hypoxic pulmonary vasoconstriction.
The authors would like to thank Miss Stephanie Grice, from the UK, for the editing of this manuscript.
Authors' Affiliations
- Global strategy for the diagnosis,management and prevention of COPD:www.goldcopd.org.
- Laurendi G, Mele S, Centanni S, Donner CF, Falcone F, Frateiacci S, Lazzeri M, Mangiacavallo A, Indinnimeo L, Viegi G, Pisanti P, Filippetti G: Global alliance against chronic respiratory diseases in Italy (GARD-Italy): strategy and activities. Respir Med. 2012, 106: 1-8. 10.1016/j.rmed.2011.10.002.View ArticlePubMedGoogle Scholar
- Agustí A, Edwards LD, Rennard SI, Macnee W, Tal-Singer R, Miller BE, Vestbo J, Lomas DA, Calverley PM, Wouters E, Crim C, Yates JC, Silverman EK, Coxson HO, Bakke P, Mayer RJ, Celli B: Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One. 2012, 7 (5): e37483-10.1371/journal.pone.0037483.PubMed CentralView ArticlePubMedGoogle Scholar
- Cockayne DA, Cheng DT, Waschki B, Sridhar S, Ravindran P, Hilton H, Kourteva G, Bitter H, Pillai SG, Visvanathan S, Müller KC, Holz O, Magnussen H, Watz H, Fine JS: Systemic biomarkers of neutrophilic inflammation, tissue injury and repair in COPD patients with differing levels of disease severity. PLoS One. 2012, 7 (6): e38629-10.1371/journal.pone.0038629.PubMed CentralView ArticlePubMedGoogle Scholar
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- Boerrigter BG, Bogaard HJ, Trip P, Groepenhoff H, Rietema H, Holverda S, Boonstra A, Postmus PE, Westerhof N, Vonk-Noordegraaf A: Ventilatory and cardiocirculatory exercise profiles in COPD: the role of pulmonary hypertension. Chest. 2012, 10.1378/chest.11-2798. in pressGoogle Scholar
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Upholding military standards with a modern day aesthetic Eastpak present the 'Padded Pak'r' backpack. Crafted from durable polyamide and emblazoned with a multi-coloured geometric print the backpack is designed with comfort and safety in mind with a padded back and ergonomic shoulder straps with SGS. Perfect for every day the rucksack features a large inner compartment and a zipped front pocket to the exterior for additional storage. Finished with two way zip top fastening and webbing top handle. Branded patch to the front pocket. - K.N. Polyamide Dimensions: H:40 x W:30 x D:18cm
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Gavin Creel in 'Out Magazine'
Theater folks populate the magazine's 'Out 100.'
Out Magazine recently released the "Out 100 – Class of 2009." The list, which featured such household names as American Idol runner-up Adam Lambert, Congressman Barney Frank and film director Pedro Almodóvar, was heavy with theater people. The magazine, which features glossy photos by Jason Bell of the honorees in a school-themed portfolio, describes its list as "the most outstanding and inspiring men and women of the year."
Here are the theater folks who made the cut: Hair star Gavin Creel, Broadway vet Jesse Tyler Ferguson, The Royal Family's John Glover, actor and 2009 Tony Awards host Neil Patrick Harris, writer/director Moises Kaufman, playwright Tony Kushner, Superior Donuts director Tina Landau, Broadway vet Cyndi Lauper, West Side Story writer/director Arthur Laurents, Bye Bye Birdie director Robert Longbottom, The Temperamentals playwright Jon Marans, director/choreographer Rob Marshall, Jujamcyn Theaters president Jordan Roth, playwright Paul Rudnick, The Temperamentals producer Stacy Shane, Shrek star Christopher Sieber, The Temperamentals director Jonathan Silverstein and The Temperamentals star Michael Urie.


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Kareena Kapoor's tax for 2012 News
Salman Khan pays Rs 8 crore income tax; Shahrukh Khan just Rs 5 crore this year!
The colossal success of Ek Tha Tiger has made Salman Khan the highest taxpayer in Bollywood for this fiscal year. But who else can measure up to that? Let's take a look at the other highest tax paying celebs and their hefty payouts
When you pay Rs 8 crore as income tax for one single year, you definitely make people raise their eyebrows in amazement. Salman Khan did just that by becoming the highest tax-payer from the world of glitz and glamour. Click here to read more -


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In the midst of significant global change and uncertainty, securitisation market participants are all asking important strategic questions about the future. It has never been more important for key market participants - regulators, government officials and all private sector participants - to come together to discuss what our markets should look like in the future, given the importance of securitisation to the real economy. We must recognise that regulatory and policy changes should and will be made. The ESF/IMN Global ABS event is the perfect forum for those discussions and senior-level networking to occur.
Given the importance of this event, members of the ESF have recommended that the event be moved to the Hilton Metropole in London in order to maximize the opportunity for participation in these key policy and client networking discussion. By relocating the event to London, and condensing the programme to two days, we are taking into account ESF member's interest in cost controls such as travel and entertainment budgets, and minimising time away from work and other important obligations. The hotel offers ample opportunity for arranging private business meetings in the many separate rooms available, while the agenda is focused on practical 'need to know' topics such as: Restoring term ABS and ABCP investor confidence, reshaping business models, the future of securitisation regulation, the roles of central banks and governments, the changing CRA environment, products that will continue and many other important issues.
With more than 2,700 attendees in 2008, Global ABS 2009 will be the essential, annual global gathering of all your industry peers. Join them this June to explore and define the road ahead for the international structured finance markets.
Mon, 06/03/2017 - 16:00
Fri, 24/02/2017 - 11:55
Mon, 27/03/2017 - 13:53
Mon, 20/02/2017 - 15:43
Mon, 06/02/2017 - 11:29
Wed, 08/02/2017 - 14:15


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Succulent salmon fillet is grilled then topped with a simple dill cream sauce. It's just right for a friendly get-together. MORE + LESS -
Perishable food should be eaten within 2 hours (1 hour if the outside temperature is over 90º).
Enjoy this "dill-icious" salmon with grilled new potatoes and corn on the cob or fresh asparagus.
© 2017 ®/TM General Mills All Rights Reserved


text: States missing out on Internet sales revenue By: Bernadette Starzee October 19, 2011 Comments Off on States missing out on Internet sales revenue It used to be that when selling out of state, retailers didn't have to concern themselves with sales tax. The U.S. Supreme Court ruled in 1992 that only businesses with a physical presence in a state were required to collect sales tax there. But since then, Internet sales have exploded, causing states to miss out on ... Subscribe Login Print, Digital & Mobile1 Year$99 Digital & Mobile Only1 Year$99 Digital & Mobile Only1 Year$99 Print, Digital & Mobile1 Year$99 Print, Digital & Mobile1 Year$99----------Digital & Mobile Only1 Year$99 Email Address: Password: Already a paid subscriber but not registered for online access yet? For instructions on how to get premium web access, click here. Forgot your password? Share this:EmailPrintLinkedInFacebookTwitterGoogle Pages: 1 2 accounting BNAM101911 Finance Long Island Ronkonkoma sales tax taxes 8:36 am Wed, October 19, 2011 Long Island Business News Bernadette Starzee


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Antibiotics Channel
Topics & Medications
Related Channels
Metronidazole is commonly prescribed to treat several types of bacterial and parasitic infections. As an antibiotic, it works to fight infections by entering bacteria or parasite cells and producing free radicals, molecules that can damage and destroy cells. The medication comes in many different forms, including tablets, capsules, skin creams and lotions, and vaginal creams, depending on the particular product.
Metronidazole (Flagyl®, MetroCream®, MetroGel®, MetroGel-Vaginal®, MetroLotion®, Noritate®, Vandazole®) is a prescription antibiotic approved to treat a variety of different infections. It comes in several different forms, such as tablets, skin creams and lotions, or vaginal cream. The medication is especially useful for infections caused by parasites and anaerobic bacteria (bacteria that do not require oxygen to survive).
(Click What is Metronidazole Used For? for more information, including possible off-label uses.)
In order to work, metronidazole must enter the bacteria or parasite cell. The cells then cause a chemical reaction to occur with the medication. This reaction produces free radicals, molecules that can damage and destroy cells. This is presumably how metronidazole works to kill bacteria or parasites.
General considerations for those taking metronidazole include the following:
- This medication comes in several different forms. The particular directions for each product can vary substantially, so be sure to refer to the information for your specific product.
- You can take regular, short-acting metronidazole tablets or capsules with food or on an empty stomach. However, long-acting, extended-release metronidazole tablets must be taken on an empty stomach, at least one hour before or two hours after a meal.
- For the medication to work properly, it must be taken as prescribed. Do not miss doses or stop taking this antibiotic earlier than your healthcare provider recommends, as bacterial resistance may develop.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD


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In the study published today in the Journal of Clinical Investigation (JCI), one of the journals with highest impact in experimental medicine, the researchers associate the activity of the DOR protein with muscle atrophy and point to DOR as a plausible target against which to develop a drug to prevent muscle deterioration in certain diseases.
DOR (Diabetes- and Obesity-regulated gene), also known as TP53INP2, is a protein involved in autophagy, a quality control process that ensures cells stay healthy. The researchers have found that increased DOR expression in the muscle of diabetic mice leads to enhanced autophagy, which in turn favours the loss of muscle mass in these animals.
The advantage of developing a DOR inhibitor is that autophagy, a process necessary to keep cells healthy, would not be completely blocked in the absence of this protein. DOR is not essential for autophagy, but acts more as an accelerator. Thus, the inhibition of DOR would only partially reduce autophagy as other molecules involved would exert their activity normally, thus maintaining the levels of autophagy in a beneficial range for cells.
"If we could treat patients with sarcopenia and cachexia, or people at risk of these conditions, using a drug to inhibitor DOR then we would be able to stop or prevent muscle wasting," explains the expert in diabetes and obesity Zorzano, head of the "Heterogenic and Polygenic Diseases" lab at IRB.
"We are showing pharmaceutical researchers a new possible therapeutic target for two diseases that seriously impair the quality of lives of those who suffer from them," says the scientist.
An answer to why type 2 diabetic patients lose less muscle than those with type 1
The study also solves a biomedical enigma related to diabetes. Physicians did not understand why patients with type 2 diabeteswho become resistance to insulin or have very low levels of this hormoneare able to maintain muscle mass or minimize muscle wasting compared to patients with type 1 diabeteswho do not produce insulinwho show a clear loss of muscle mass. The IRB researchers demonstrate that the repression of DOR in muscle cells of type 2 diabetic animals allows the maintenance of muscle mass.
"We interpret DOR repression, which occurs naturally, as an adaptation mechanism to preserve muscle mass and to maintain greater muscular strength in type 2 diabetics," explains David Sala, first author of the study, who has recently started a post-doctoral training period at Sanford-Burnham Medical Research Institute, in La Jolla, California.
Besides working with mice, the scientists have performed experiments on biopsies from skeletal muscle of patients with diabetes and patients resistant to insulin, thanks to collaboration with clinicians from the Universit Lyon 1, in France, and from the Medical University of Byalistok, Poland, also included among the authors.
Contact: Sònia Armengou email@example.com 34-934-037-255 Institute for Research in Biomedicine (IRB Barcelona) Source:Eurekalert |


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Ask Sam | Sam Smith opens his mailbag | 01.21.11
The contents of this page have not been reviewed or endorsed by the Chicago Bulls. All opinions expressed by Sam Smith are solely his own and do not reflect the opinions of the Chicago Bulls or its Basketball Operations staff, parent company, partners, or sponsors. His sources are not known to the Bulls and he has no special access to information beyond the access and privileges that go along with being an NBA accredited member of the media.
This melo to the bulls talk is coming up again with the Nets dropping out. So i know the nuggets dont want deng but are you telling me no other team would want him where we can flip him for more assets in a 3 way trade?
Ninab Maradkel
Sam: Yawn. Yes, I believe the Bulls could find a taker for Deng, especially since he is having a good season. But Carmelo Anthony does not want to be in Chicago. No matter what you may have read. If he did, he could have arranged a deal long ago. The Bulls have remained interested, as they should, but everything they and most everyone else continues to hear is Anthony and his wife want no part of Chicago. I've written many times that if this were solely about winning and being on the best team, Anthony would work to arrange a deal to the Bulls. He could do that. But the Bulls have yet to get one signal that Anthony desires that. If he did, why would there be a half dozen stories every day involving Anthony going to New York or New Jersey? So now, the Nets finally got the hint Anthony won't go there and have backed out of any deal. It wouldn't be easy, but I think the Bulls could pull off a deal that would satisfy the Nuggets and pay Anthony his extension. He seems only to want to go to New York. I suppose he could have a change of heart. Perhaps someone will get to him and explain where the best chance to win is, but no one seems to as yet. But that's free agency and free choice. After all, everyone thought LeBron's best chance to win now was in Chicago as well, with a center and point guard and the chance to bring with him Bosh, Wade or Boozer, etc. He said no, and is playing with a good team that starts Carlos Arroyo and Zydrunas Ilgauslas instead of Rose, Wade, LeBron, Taj and Noah. That lineup probably would be better than any among the champion Bulls of the '90s. They must just hate stuffed pizza and the Bears.
So, as it seems that Melo is on his way to NYK and Fields possibly being included in the deal, do you feel that the Bulls can come out of it with Afflalo?
Ivan Krpan
Sam: His name gets thrown out a lot, though it certainly seems that Anthony will leave. I guess if Denver decides to blow up its team and go for draft picks, it would be possible. But I don't see that yet and Afflalo remains a cheap player for them as it is not certain if they will retain Chauncey Billups.
The Bulls need a solid shooting guard. The Knicks need draft picks to facilitate a trade for Melo. Why don't the Bulls trade this years pick, the future pick from the Bobcats, and James Johnson for Wilson Chandler of the Knicks. The Knicks could then offer the Nuggets Curry's expiring contract, Danillo, Landry Fields, and a bevy of draft pick (at least three 1st rounders) for Carmelo. That would also give the Bulls the DePaul alum who is a more than capable 2, 3, or 4.
Gordon Yeboah
Sam: I don't believe Chandler is a shooting guard, as he's more a three and plays four for New York, plus his statistics are inflated as that happens when you play for a D'Antoni team. I have heard these kinds of suggestions with Fields as well, though the sense I get is Anthony might not go to New York in trade during the season if they have to give up too much to get him. In the end, sure, I can see him taking the money and doing so, thus maybe it's a possibility because the Nuggets without the Nets in it probably are drawing awfully close to getting nothing. As I've written, if I were them I'd forget all these bad draft picks, just clear their payroll when Anthony leaves, have the trade exception, assuming it holds through the labor deal, and then be in better position to take players you want. You are not building a team with picks from the Bulls with them having one of the league's best record and a Charlotte pick that might not mature for five years.
Here's a three-way trade proposal:
Bulls - Carmelo Anthony
Dallas - Luol Deng
Denver - Caron Butler, Taj Gibson, CJ Watson, Bulls 1st rounder, Bobcat's 1st rounder
Christopher Howard
Sam: Now Lu's going to be mad at me again, since he thinks I'm always trying to get him traded. I am not and have said I consider him a top-10 small forward. Though, yes, Anthony is higher than that. The issue, as I said, is Anthony, who doesn't seem interested in Chicago. I think at some point Denver will realize this and perhaps seek out a rental, which I think, actually, could have him going to Dallas with Mark Cuban then so confident of himself that he'll believe he can talk Anthony into signing there. Cuban has an issue the Bulls don't: His window with his star is closing while the Bulls' is just opening. So the Bulls never would take a shot and give up players unless they got an assurance from Anthony, which seems doubtful. You could see Cuban taking that shot and perhaps at least persuading Anthony to opt in next season for his final $18 million, as Carlos Boozer did in Utah.
So with the Nets supposedly out of the Melo trade talks, the Melo camp is rumored to be seeking a trade to the Bulls. With LeBron there was also a lot of Bulls speculation, but he ended up in Miami with his buddies where he wanted to be all along (as evidenced by the three signing contracts which all expired at the same time). Melo has made it clear his preference is to play for the Knicks. Since Melo and LeBron have the same agent team, do you think this Bulls rumor is merely an attempt to leverage the Knicks into making a move now so Melo can get his money? There appears to be little chance of a Bulls deal given the Nuggets' lack of interest in Deng and the new contract extension for Noah. I for one would love it if Gar came out and denied any interest in Anthony, as the Bulls already have their superstar in Rose. I think adding Anthony would only create tension/drama as to who is the leader of the team or face of the franchise and would ruin the team chemistry - as this is clearly Rose's team. I love the make up and future of this team and would hate to see it ruined by breaking it up for a spotlight craving, no defense playing, diva like Anthony.
Scott Lucas
Sam: Yes, I think you are on to something there. It is quite possible and even likely given how they have used the Bulls before, given the agents care nothing for any team. I don't completely blame them, but their job is to do the best for their client. Sometimes you wonder if they are or, or trying to enhance their own positions to get the next client or collect a big fee. In any case, with many agents these days you have to shower after talking to them. I'd like to see on some level the Bulls do that, though I also like Dirty Harry movies. The Bulls may have an outside chance at Anthony, as they did with LeBron and Wade, so they are probably stuck playing it out and trying to land him. Anthony is about himself in a lot of respects, but he could help the Bulls and give them another star to compete with the star studded teams that are becoming the blueprint. Yes, you can win the other way as the Pistons showed. And maybe with a group built around Rose you can. With a high level shooting guard, I like the Bulls' look. But you have to stay in the game to see if you have a shot.
I don't get the whole Mello thing. Yeah, he can put up big numbers, and the Bulls need another scorer, but what's his addition do for Bulls on the defensive end? Thibs hasn't hesitated to pull Boozer for failing to play defense, so what's he do when Mello starts allowing more points than he scores? Thibs is already intense enough roaming the sidelines, but I think his head would explode every time Mello failed to step in and take a charge. I love the character of this team and I hate the thought of giving up Deng or Taj at this point for a guy who really doesn't want to be here.
Marty Weitzel
Sam: Yes, there are views that he is a poor defender and also a ball stopper on offense, so there might be issues. But I believe the Bulls would take a chance if they could. I doubt they will get the chance.
I'm sure you're probably sick of all the OJ Mayo talk and I just finished your article and you said a trade for shooting guard doesn't seem likely because of the Boozer injury. I just don't see how giving up our 1st round pick and our first round pick from Charlotte wouldn't be a fair trade. I think that would work out for both parties. We get Mayo and get to keep Gibson and they get two first round picks and one of those picks could end up being a lottery pick. That's a pretty good deal for a guy who is coming off the bench and not getting alot of minutes. Mayo isn't exactly playing too well for them right now.
Tony Ayala
Sam: Fair for whom? So the Grizzlies are desperate to compete and at least make the playoffs given they are in a small market and need to show their fans a level of competition to get fans to pay for games. So they are trading a player averaging double figures for a low draft pick in a draft which isn't considered very strong and a pick they may not get for five years, and if they get it sooner it may be just another mid level, non lottery pick. You don't think they can do better than that for the former third pick in the draft, even if he is being misused. I agree they may not re-sign him, but they don't have to decide that this season. So what's the hurry? Getting Taj plus would be the minimum for them and even then it might not be enough.
Hopefully OJ Mayo's performance Monday should quiet the trade Taj to get a better 2 guard noise. Mayo, while a good player, is essentially a Larry Hughes type of player - at his most effective as a player if he dominates the ball and isn't good enough to dominate the ball and have his team win. So he would take away from Rose's ability as he doesn't shoot well and isn't a great defender (which Ronnie Brewer has been). OJ Mayo is a bad fit for this team and don't forget that Brewer was a lottery pick too, just not as recent. I submit that winning in the NBA isn't all about compiling an all-name team.
Robert Lininger
Sam: I think the Bulls would still go for him if it didn't include Taj, but as I've said, I cannot see Memphis even considering that.
Thibs has been a great coach with his offensive plays and his defensive philosophies, but his substitutions are awful and downright offensive. For one there is no reason for bogans to start over Brewer. The sub for Brewer should then be Korver with Bogans only used when necessary. The second Bobcats game is a perfect example. He continued to wear out Deng and never considered a short run James Johnson to spell him some relief. The same goes with Rose - he played Rose the entire third and took him out for a break at the 9 minute mark in the fourth. Doesn't it make sense to follow Phil Jackson's subbing habits and sit the player down in the last seconds of the third and rest him in the break and for the first couple minutes of the fourth and then have them finish the game in crunch time fresh? Don't even get me started on keeping Gibson and Thomas in for the almost the entire 3rd and 4th quarter of that game and never subbing Asik, Scal or JJ! We were getting outhustled and outrebounded down the stretch because our players were gassed.
Nitin Malhotra
Sam: This is the anti-Thibs, anti-Bogans argument I get in various forms daily. I guess you can nitpick and I have my disagreements as well, which I state in my postgame columns. But the fact is the Bulls have a way, way better record than I or anyone imagined at this point in the season without Boozer and Noah. Going into the season, knowing what you know now, you wouldn't have the Bulls at .500. Would they be 35-7 with a different rotation? Thibs could do some things differently, but he's had a short roster all season and does play 10 guys, so it's not like he doesn't use his bench. When bench guys perform they generally stay in, though like all coaches he has a quick hook for young players and rookies. Nothing new there. At least he gives Asik a shot, which we weren't even sure he would until mid season. Though from Thibs view the meanest thing you could have said was he should follow Phil Jackson's model more. I suspect he'd tell you if he had Kobe, Pau, Odom and the rest, he would.
I'll spare you questions about sitting Keith Bogans or playing James Johnson as its clear Thibodeau has his mind made up on those issues. Has anyone ever asked him either (i) why doesn't he run more clearouts for Rose without a screen (he did it some at the end of the Charlotte game last night) or (ii) why he doesn't run more 1-3 pick and rolls with Korver? Since virtually every team is blitzing the pick and roll hard, Rose has to give the ball up almost immediately and, more often than not, Kurt Thomas becomes your primary playmaker. If we mix in some isolation with weakside action, the lanes may open up again for Deng or Brewer to come free to the basket. Alternatively, I'd love to see Korver set the high screen occasionally. It's not like defenses are that concerned about Taj or Kurt when they come up and screen and even when Boozer gets back, he settles at the foul line and doesn't clear his defender out of the way.
Jay Augustyn
Sam: He generally has a good offensive system, so it's not a great issue. Yes, you'd like to find more ways of scoring, but it's not like with Bogans and Thomas in the lineup they are leaving Korver. It's why I've mentioned at times starting Korver, though as you note Thibs has settled on what he wants to do there and it has been working. When it doesn't, there'll be more reason for second guessing. He doesn't see Korver as a very good pick and roll player and he's not an isolation type coach as the offense tends to become stagnant when you do that. I would like to see Korver off more baseline screens like the Ray Allen stuff they seemed to be running more for him earlier, but the larger issue now is to get back the injured players.
I love Derrick Rose as much as anyone, but am I the only one who cringes when the United Center fans chant "MVP" when he's at the free throw line or makes a great play? For all the great strides Derrick has made as a player, I still can't get over the number of times turns the ball over carelessly or his penchant for jumping in the air with the ball before knowing who he's going to pass it to...only to see him heave it out of play. Too many people are lauding his incredible plays and ignoring these correctable and often costly gaffes.
Robert Kehoe
Sam: You are correct. He is not perfect. Close. He also allows the trap to stop him at times when he could beat it, but if he did all those things perfectly he'd be the best ever because Jordan always forced shots into triple teams, went back for the ball instead of attacking to take the defense back and I recall a triple double in an All Star game when he had 10 turnovers and no one really was even trying to steal the ball. Though I also cringe at those MVP chants. Like Kobe said, they do it in Milwaukee for Earl Boykins. C'mon, as Mark Jackson would say, we're better than that.
A few days back, the bulls played the pistons and, although he didn't play particularly well that night, i think Tayshaun Prince would be a nice addition to this team, hypothetically replacing luol, in case the bulls indeed end up trading deng next summer. He's a expiring contract and a similar player, but would cost (i suppose) less money, so the bulls could afford a starting caliber shooting guard. Althoug i apreciate deng's abilities, i think a player who could help rose with ballhandling and playmaking duties, as well as provide spacing with good shooting is the missing piece for this team to become a perennial contender in the east for many years. Since i don't know any player that fits this description and is avaliable, i guess i should bring my talents to the internet and find someone to replace luol and his salary.
Paulo Ferreira
Sam: It's actually a pretty good idea. The part about shooting guard. I cannot see how the Bulls could make it happen this season, as Prince makes too much money and the Pistons won't take back any contracts as they are only in a dumping mood and Prince is valuable in that his money comes off the books. But I think he can play shooting guard because you can play pick and roll with him, he can defend and make a shot and if the Bulls could figure out a way he would be a good pickup after the season.
Looks like the Bulls are standing pat unless Denver would get desperate. However, one name I haven't seen mentioned as a possible two guard is Marcus Thornton from the Hornets. Would he be an upgrade, would he be available and what would it take to acquire him?
Sam: His name has come up, with fans mostly, and Wednesday he basically won the game for the Hornets. He is in and out of the lineup, but you have to give teams a reason to trade guys who help them. It's not like the Bulls have that much to offer.
I just read that Toronto Raptors are buying out Peja Stojakovic's contract, do you think the bulls would take a chance at him to back up luol? They never use James Johnson and they really have no back up small forward.
Daniel Mallen
Sam: Of course, he is hurt a lot, so maybe you move Deng to play some shooting guard, which you figure he could do, but that hardly reduces his minutes. I suppose it would be reasonable, but I figure of he's healthy Peja would want to go where maybe he could get a deal for next season and maybe where he'd get more time. Like Dallas. It appears Peja is set to sign with the Mavs as he said he wanted to be in the Western Conference, anyway.
I assume you saw this, but just had to pass it along in case you missed
it. Dwayne Wade just makes me laugh:
"I stopped following it," Wade said. "It's getting to the point where
you're just like, move on already or don't. I'm sure 'Melo is more tired
of it than anybody. But it's just to the point, as a sports fan, you're
just, ?All right, it's just enough."'
Really Dwayne? After you and Lebron and Bosh so happily hijacked the NBA
headlines for over a year with your free agency, playing your little
games. Looks like the Heatles, or whatever they are calling themselves,
are not enjoying sharing the spotlight for a while with Melo.
Matt Maloney
Sam: Yes, there is a not so gently irony in there. "So enough about me talking about me, what do you think of me?"
Which pair of players would you rather have?
Rose and Boozer or Durant and Westbrook?
Bill Ligas
Sam: That is a tough one. Can't I have Rose and Durant? I've gone back and forth on this one as Westbrook really isn't a point guard and Durant isn't a power forward, though if he toughened up some and gained some weight that would be a great position for him in this NBA. For now I'd probably have to go very reluctantly with Durant and Westbrook for health and age, though I'd have them more in control as they don't really play well together because they each just look to shoot and Westbrook is very overrated as defender. I'd take Rose over Durant if you gave me that choice, but Boozer, while I'm fine with him, is too much a risk three or four years down the road. For right now, I take Rose and Boozer. In three years, I take Durant and Westbrook. How's that for wimping out?
I just read an article at bulls.com about chris bosh complaining about omer asik diving for that loose ball which he eventually landed at bosh's ankles. he said that omer has to watch for someone's leg. is he being reasonable? or he is just "over-praising" himself that you should not hurt him that way since he is one of the big three?
Carlo Berango
Sam: He actually had a physical just before the game and discovered he really was made or porcelain and was concerned he'd break.
Has there ever been this many great point guards in the league at one time? I mean, Charles Barkley rattled off his top 5 and didnt even get to Steve Nash...
Brian Jackson
Sam: I know we like to get excited about point guards in this era, and there are many good ones, though few, truly, who have made a major difference in winning big, like Williams, Paul, Westbrook and for now Rose. How about these point guards: Oscar Robertson, Jerry West, Bob Cousy, Guy Rodgers and Richie Guerin in 1962. Or these in 1972: Pete Maravich, Lenny Wilkens, Nate Archibald, Gail Goodrich, JoJo White, Dave Bing, Calvin Murphy and Norm Van Lier? And that was with Earl Monrie hurt that season. Or these in 1982: Magic Johnson, Maurice Cheeks, Isiah Thomas, Rickey Green (eventually replaced by John Stockton), Ray Williams and Michael Ray Richardson? There have been some great ones throughout the years.
Was any championship team in the last decade built around the Point Guard position? In the 90's the Bulls won six times being Jordan the face of the franchise and Scottie Pippen behind him. Is it possible for us to win with a Rose/Boozer oriented team? Or do we need some star upgrade?
Alexandre Monnet
Sam: Jordan was the first to lead a team to titles as a shooting guard, though Magic was really the first point guard. The league has changed whereas you used to need a dominant big man, but the rules changes have limited what big guys can do and opened the game more for guards. While you can make an argument for the Bulls once Noah and Boozer are healthy—and given both have had injury plagued careers so far you can never be fully sure—the Bulls clearly are missing another offensive player, and especially some shooting. But you cannot be a full team coming out of free agency where you have to go under the cap and stay below with no exceptions. The Heat has more higher level talent, but they hardly are a complete team, either, and my guess is they went into this looking to play for a title next season. The Bulls issue will be balancing the aging and injuries of Boozer with the development of Rose and Noah and trying to assure they all come together without missing out on the opportunity.
Isn't it true that the Utah Jazz traded away their draft pick to get better and ended up trading Magic Johnson? If that is true then why don't Bulls fans be patient because trading for a SG right now still won't make us any better than Boston, Miami, or Orlando. We will give them a good fight but overall in a seven game series, I just don't see it. I would love to be proven wrong though. I say be patient and enjoy the success we will have this year.
Jackie Lane
Sam: Yes, the Lakers got very lucky, and so did the Bulls in getting Rose. So that's the fulcrum where the Bulls rest now. Do they try to take a shot now knowing nothing is guaranteed and it's not like the Lakers and Celtics and Heat and Spurs and Magic are unbeatable? Or do they carefully bide their time so they can get a higher level player after this season and not just a marginal improvement and put themselves in position for a solid five or six year run? Because, after all, this is the first year this group is together after a virtual makeover of the entire roster and they haven't played together healthy yet for one game this season. But the nature of being a fan is being impatient and wanting your success right away given the Bulls have shown impressive signs. My guess is management is more on the cautious, building side now believing they can put together a long run, so why risk a quick fix.
Any chance Deng makes a defensive team this year?
Fancis Manaloto
Sam: Let's not get too carried away here. He does a very nice job, works at it and tries, which is more than can be said for a lot of his contemporaries. But he's not in the top 40 in any of the major defensive categories, like blocks, steals or rebounds.
What no complaints from Stan Van Gundy that the league shouldn't have games on MLK day and that players need to be with their families.
Mike Sutera
Sam: Apparently, no one in the media talked to him that day. Stan has, and I guess we should understand, replaced Jeff Van Gundy with the rant of the week, really hysterical stuff as this week Stan was wondering why the league doesn't make the coaches stop talking to the media if they get upset with what the coaches say and then fine them for talking to the media. He doesn't want to talk anyway, or so Stan insists, and if the league is worried about its image just release statements about how great it is. We would miss him if he weren't coaching. And talking.
How much better can Rose really get? I mean if he is just scratching the surface, What will he be like at age 25 when his upper body is fully grown into? could he be a 28/10/8 guy?
Oh and how about that Charles Barkley is about the only national media guy to have much positive to say about the Bulls?
Matt Reev
Sam: That is one of my greatest concerns for the Bulls, that I agree with Barkley. As for Rose, he will get better because he works so hard at it, though not necessarily with numbers because once the Bulls improve the roster, his scoring should go down some and once they are healthier up front his rebounding should. He does now what he has to, which makes him a star. If he is averaging 28, 10 and 8 the Bulls could be in trouble.
Do you think Blake Griffin should be able to play in the All-Star game? He is the next big thing since sliced bread, before him all we had was sliced bread.
Sean Carino
Sam: I'm quite confident Griffin will be an All-Star, the first rookie to play in the game since Tim Duncan. Actually, I never understood the big deal about sliced bread, I don't eat it and wish people would think and stop using all these moronic clichés. Sliced bread was first used in 1928, and a year later we were in the worst economic depression in the history of our country. The French don't know much, but they know food and drink and they don't eat sliced bread and have their bread in loaves. Basically, my view is things never were worse once we got sliced bread and I would henceforth like to hear people say in a tragedy this was the worst thing that happened since the invention of sliced bread, which would be much more accurate.


text: Violence, Weeping Men, & Lizzie Grubman Star In RHONJ PremiereTracie Egan Morrissey5/17/11 10:50amFiled to: WatchReal housewives of new jersey christeningreal housewives of new jerseyTeresa giudiceMelissa gorgaJoe giudiceJoe gorgaClipsreality bitestweetFb106EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Danielle Staub who? Seriously, that lady will not be missed (although, you can still see plenty of her at Scores, where she's now a stripper). Including Teresa's brother Joey, his wife Melissa, and their first cousin Kathy was the best casting decision Bravo could have possibly made. (Not to mention Kathy's husband Richie, with his cross nestled in his chest hair.)Within the first five minutes of this season people were screaming and wasted, fists were pounding, and food was flying up in the air—all at a baby's christening. And BTW, what's the deal with this family and their christenings that rival wedding receptions? Melissa mentioned in her Bravo blog that they also had a Michael Jackson impersonator. That wasn't the only interesting thing she said. Melissa stressed several times that her husband makes an "honest" living:AdvertisementAdvertisementThis amazing man, who built everything with his own two hands the honest way since he was nine years old.It seems like the entire family rivalry boils down to all of them complaining and crying about how they don't get enough attention from one another, but when they are actually all in the same room together, they don't actually hang out, but rather complain about how they never hang out.The weirdest thing, though, had to be Lizzie Grubman's cameo as Ashley's "boss." Are we to expect to see more of her this season as Ashley cries her way into a PR career?Reply106 repliesLeave a reply


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19 fun car road trip activities
Turn an ordinary drive into a world of fun adventures and possibilities. more
Download our BUMPWATCH Pregnancy Tracker. Everything there is to know week by week. FREE
If you're pregnant and wish to exercise there are a few things you need to consider. Before undertaking any exercise program, seek advice from your medical professional as to whether you're clear to exercise.
When exercising during pregnancy, wear a heart rate monitor and do not let your heart rate get above 140 bpm. Use a self exertion test, do not exert yourself more than you would during a brisk walk, and you should be able to have a conversation at all times.
Use a reduced range of motion in your repetitions. You do not want to go into a full squat, lunge or weight bearing exercise as relaxin and elastin are both elevated in your system from the time of conception. This means that your joints become ten times more loose than normal to allow the babies head to come out during labour. This means you can injure yourself because your tendons and ligaments are so soft.
When starting an exercise program at any stage in your life especially during pregnancy, using a Fitness professional experienced with pre and post natal clients is a must. This will make sure you are exercising correctly, appropriately and safely at all times.
This resistance program uses only your body weight and the furniture typically found in a home.
This exercise is done using dining room chairs to assist with the technique, help with balance and reduce range of motion. Place one chair against a wall. Sit on it with another chair in front of you, with the back facing you. Place your feet about shoulder width apart angled at approximately 45 degrees. Grab the top of the chair in front of you, using it to help with your balance on the up and down movement of the squat.
Stand up using your legs, keeping your knees at the same angle as your feet. Do not lock your legs out. Keep your knees slightly bent at all times. Then squat down, lowering yourself towards the seat of the chair. Keep your back straight and your abs tight. Push up through your legs just before you are about to touch the seat. Repeat. Excellent to tone and strengthen thighs and gluts!
Lunges during pregnancy can be done in the home using a dining room chair to help with balance. Stand next to a chair, placed on your left hand side. Put your left hand on the top of the back of the chair. Step back with your left leg into the lunge position, keeping your front knee in line with your second toe and your back knee under your hip. Keep your feet on parallel lines as wide as your hips. Always keep your back straight and remember to push up through the heel of your front foot. Repeat on the other side. Perfect for the inner and outer thighs!
This exercise is performed on all fours, hands under shoulders, spine parallel to the floor, thighs perpendicular to the floor. Tighten your abs and push your lower back up into a flat position. Hold for 1-3 minutes. Great to help maintain your core strength during pregnancy!
Repeat exercises 1 and 2 with 15 - 20 reps x 2 sets 2- 3 times a week
This article was created for Kidspot - Australia's parenting resource for family and health


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Artist description:
Wow, I failed so bad with this.Buildings are hard to draw.
Java Draw Created Nov 19, 2013 736 x 1024px Unless noted Copyright 2013 chance2.
We encourage you to submit a comment and let the artist know what you think of this drawing. Please log in or join to post a comment.
Post a comment
super cool; reminds me bit of the infamous games tho i only played one of em lol :p i agree theyre hard-but u did well :D luv d dourness/characters favs
no fail this is awesome ! i would totally play a game with this cool bg and the characters , maybe the lines are a little bit strange * their angle ) but for me this makes the drawing even better :))
I think you done brilliantly with the building and I love that monster what a scarey creation like fav
well drawn, buildings are easy to draw, they are just straight lines, lol, liked :)


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Prepare your Virginia students for the new Standards of Learning testing in mathematics.
Available for reading and math, this powerful online program combines an adaptive assessment with instant reporting, and engaging differentiated instruction customized for each student's unique needs.
Accurately diagnose and provide differentiated instruction in mathematics.
Strengthen problem-solving and key math skills with the Extensions in Mathematics® Series. Students build computational fluency and conceptual understanding through:
To create a quote, add the quantities you'd like to purchase and select the action at the bottom of the form. Your items will be automatically added to your quote.
Extensions in Mathematics offers a balance between computational fluency and conceptual understanding. Lessons focus on one skill at a time, using one or more graphic organizers such as:
A final review assesses math skills.
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Jill Rhoades, Pennsylvania


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P03020from The Great War: Britain's Efforts and Ideals, Making Guns: Turning a Big Gun
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JamesHarmon McQuilkin gave props (18 Jan 2013):
fab colours and textures
John Linton gave props (19 Jan 2013):
BLEUErrific AZUREntry into JPG's Theme Park!


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Why solar?
Electricity prices are rising as fossil fuels are depleted. Photovoltaic power system saves you money by guarding you against future price increases on your electric and natural gas bills because solar energy costs are fixed. The solar industries are growing, and that provides local jobs and economic development opportunities. For every million dollars invested in solar power, about five to fifteen jobs are created, but for every million dollars invested in oil, only 1.5 jobs are created. Using solar energy reduces electricity demand and provides additional electricity for the grid when it generates a surplus.
How does it work?
Photovoltaic (PV) systems directly converts sunlight into electricity enabling homeowners and business owners to generate some or all of their daily electrical energy needs, including nighttime. In addition, the building is always connected to the electric utility at all times, so if the power requirement were above what the solar power system can produce, it would be drawn from the electric utility. Moreover, a solar system pays for itself. Monthly payments for a system can be equal to or less than your current utility bill.


text: Everything you need to know about Dragon Quest By Henry Gilbert News Confused about the 24 year-old franchise? You'll find the answers within Shares Page 1 of 4: Page 1 Page 1 Page 2 Page 3 Page 4 1 2 3 4 Current page: Page 1 Next Page Page 2 ABOUT THE AUTHOR Henry Gilbert Henry moved from the suburbs of northern Florida to work at GR+, and hasn't looked back once in seven years. When not collecting Mario toys, you can find him constantly checking his Twitter. Topics Role Playing Adventure Dragon Quest VIII: Journey of the Cursed King Dragon Quest Heroes: Rocket Slime Dragon Quest Swords: The Masked Queen and the Tower of Mirrors Dragon Quest IX: Sentinels of the Starry Skies Dragon Quest IV: Chapters of the Chosen Dragon Quest V: Hand of the Heavenly Bride Dragon Quest VI: Realms of Revelation Show more We recommendBy Zergnet


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2013 Social Security Taxable Wage Base
Posted on October 16, 2012
The Social Security Administration has announced that the 2013 Social Security taxable wage base is increasing to $113,700, up $3,600 from the 2012 taxable wage base of $110,100.
The 2013 FICA tax rate for employees will be 7.65, up from 5.65 in 2012. This is the combined rate for Social Security and Medicare. The Social Security portion is 6.2% on earnings up to the taxable wage base of $113,700, and the Medicare portion is 1.45% on all earnings.
We will keep you informed of any further changes.
For more information, visit the Social Security Administration website.


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UNLV was unable to sustain its early momentum from doubles and was eliminated 4-1 by San Diego State in the quarterfinals of the Mountain West men's tennis championships Thursday in Fresno, Calif.
The Rebels, who were the No. 6 seed, had won two of the three matches and taking the single point from doubles as the No. 1 team of Denys Pume and Ace Matias won their match, 8-7 (2) as did the No. 3 team of Jakob Amilon and Dimitar Petrov, 8-5. But the third-seeded Aztecs dominated in singles, winning four of the six matches.
UNLV finished its season 13-11. San Diego State (12-11) will meet No. 2 New Mexico in Saturday's semifinals. The other semifinal has No. 1 Boise State meeting No. 4 UNR.
UNLV did place three singles players — Matias, Pume and Tamas Batyi — on the All-Mountain West squad. And Matias-Pume also were named All-Mountain West in doubles.


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FRIDAY, Nov. 11 (HealthDay News) -- Vaccination has greatly reduced the incidence of Haemophilus influenzae type b (Hib) among young children in the United States over the past 20 years, a new study finds.
That strain of flu was once the most common cause of bacterial meningitis. The Hib vaccine was introduced in the mid-1980s.
But the researchers also found that other strains of H. influenzae continue to threatren the youngest and oldest people in the United States, according to the study published online Nov. 11 in the journal Clinical Infectious Diseases.
The analysis of national data showed that the highest rates of disease from non-b type strains occur in adults 65 and older and infants less than 1 year old. Among infants, most cases occur during the first month of life, with premature and low-birthweight babies the most vulnerable, according to a journal news release.
Among adults 65 and older who become ill because of H. influenzae, nearly 25 percent die, the release noted.
A disproportionately large number of both Hib and non-b type infections continue to occur among Native American and native Alaskan children, the study found. The reasons are not fully understood and should be the focus of future studies, a researcher said. Possible factors include poverty, crowded households and poor air quality.
More information
The MedlinePlus Medical Encyclopedia has more about the Hib vaccine.
-- Robert Preidt
SOURCE: Clinical Infectious Diseases, news release, Nov. 9, 2011
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This video offers over
17 minutes of multiplayer gameplay footage from Rise of the Triad, the
upcoming remake of, well, Rise of the Triad. Fighting the trend of shooters
growing slower to accommodate regenerating health and other soul-crushing
elements, the clip shows the game's throwback movement speed, which seems as
fast as the original DOOM, which we recall had players running at the equivalent
of 90 MPH.
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