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Forever Family: My Daughter's Foster Mother is Still Part of Our Lives
All Adoption Stories
A Baker's Dozen: Building Our Family
The first day of school is daunting for most kids, but it can be especially hard for children who recently joined a family through international adoption. Even if they attended school in their birth country, the schools in the United States will be much different. There are many things to consider when preparing your children to head back-to-school. Here are ten tips to ensure success.
However, despite all of the planning and preparing, something may still go wrong or be forgotten. Hopefully your child's first day will go better than my youngest first day of first grade this year, when he was sent home because he had a stomach bug! Just remember to take a breath and roll with the punches, tomorrow is a new day!
MLJ Adoptions is a Hague Accredited International Adoption Agency based in Indianapolis, Indiana. We provide ethical, compassionate and attentive adoption services to loving and committed families from across the United States and around the world. We've successfully placed over two hundred and fifty children through our international adoption programs in Bulgaria, Burkin...Learn more, see kids, or contact agency 617 E. North Street Indiana
21 Aug 2017
20 Apr 2018
Its not a surprise that families come in all shapes and sizes!
Between a Rock and a Hard Place
Includes the "bible" of homeland visit planning a
A beautiful adoptee story
Changes are difficult. Think ahead of what you can do during the crucial transition period for both you and your child.
A reflection on adopting an older child with special needs
Be prepared to be amazed!
US Department of State Poses Extreme Restrictions on Child Advocacy for Adoption


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READ Famous Circle In The Square Theatre School Alumni
List Rules People on this list must have gone to Circle in the Square Theatre School and be of some renown.
List of famous alumni from Circle in the Square Theatre School, with photos when available. Prominent graduates from Circle in the Square Theatre School include celebrities, politicians, business people, athletes and more. This list of distinguished Circle in the Square Theatre School alumni is loosely ordered by relevance, so the most recognizable celebrities who attended Circle in the Square Theatre School are at the top of the list. This directory is not just composed of graduates of this school, as some of the famous people on this list didn't necessarily earn a degree from Circle in the Square Theatre School.
Examples of graduates on this list include Kevin Bacon and Benicio del Toro.This list answers the questions "Which famous people went to Circle in the Square Theatre School?" and "Which celebrities are Circle in the Square Theatre School alumni?"
Kevin Norwood Bacon is an American actor and musician whose films include musical-drama film Footloose, the controversial historical conspiracy legal thriller JFK, the legal drama A Few Good Men, the historical docudrama Apollo 13 and the mystery drama Mystic River. He currently stars on the Fox ...more
Age: 59
Birthplace: Philadelphia, Pennsylvania, United States of America
Also Ranked
#63 on The Best Marvel Movie Actors Ever
#22 on The Best Living American Actors
#42 on The Greatest Actors Who Have Never Won an Oscar (for Acting)
#48 on The Best TV Actors of All Timesee more on Kevin Bacon
Benicio Monserrate Rafael Del Toro Sánchez, better known as Benicio Del Toro, is a Puerto Rican actor, film producer and film director. He won an Academy Award, a Golden Globe Award, a Screen Actors Guild Award and a BAFTA Award for his role as Javier Rodríguez in Traffic. He is also known for his ...more
Age: 51
Birthplace: San Germán, Puerto Rico
Also Ranked
#88 on The Best (Male) Actors Working Today
#34 on The Hottest Silver Foxes
#13 on The Greatest Non-White Actors in Hollywoodsee more on Benicio del Toro
Andrew Thomas McCarthy is an American actor, award-winning travel writer and television director from Westfield, N.J. He is known for his roles in the 1980s films St. Elmo's Fire, Mannequin, Weekend at Bernie's, Pretty in Pink, and Less Than Zero, and more recently for his roles in the television ...more
Age: 55
Birthplace: Union County, Westfield, Contiguous United States, United States of America, United States, + more
Also Ranked
#29 on The Greatest '80s Teen Starssee more on Andrew McCarthy
Kristen Johnston is an American stage, film, and television actress. She is most famous for her two-time Emmy Award-winning role as Sally Solomon in the television series 3rd Rock from the Sun. She also starred as Wilma Flintstone in The Flintstones in Viva Rock Vegas. She stars as Holly Franklin in ...more
Age: 50
Birthplace: Washington, D.C., United States of Americasee more on Kristen Johnston

subset: commoncrawl


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You have searched for Gururaj Ananda Yogi
LAST UPDATED : Apr 19, 2018, 07:48 PM IST
- Justice Loya verdict: Yogi seeks apology from Rahul
LUCKNOW: UP Chief Minister Yogi Adityanath has asked Congress president Rahul Gandhi to apologise for what he claims was a conspiracy to malign BJP national president Amit Shah by alleging that Justice Loya had been killed. Welcoming the Supreme Court decision to not allow a probe into Justice Loya's death, the CM said that PILs are increasingly being used to settle political scores. "PILs were meant for cases of public concern. However, they are now more like political interest litigation. The SC judgement has exposed Congress and its allies by observing that Loya's death was natural and that the PIL for investigation into the case was filed due to political reasons, to take revenge," the CM said. He further alleged that the PIL was also a conspiracy to malign the Supreme Court itself. "Rahul Gandhi had held a press conference on this issue and about 150 MPs had signed a letter asking for investigation into Loya's death which was then submitted to the President. This political drama was a conspiracy against democracy to bring dishonor to the SC and to BJP national president Amit Shah. This conspiracy has been unmasked today," said Yogi. The conspiracy, he claimed, was also aimed at spoiling the environment in the country and creating instability, while also trying to finish off Shah politically.
- UP Minister terms Yogi as a 'weak CM', taunts at PM Modi
VARANASI: UP minister and president of Suheldev Bharatiya Samaj Party (SBSP) Om Prakash Rajbhar not only termed the CM Yogi Adityanath as a weak CM by saying that even low level officials do not follow his orders, but also indirectly mocked at Prime Minister Narendra Modi and AICC president Rahul Gandhi saying in election times leaders come with such promises of making cities like Kyoto, California and Singapore. Talking to reporters here on Thursday, Rajbhar said that there are lots of laws, but these are not enforced in the state. "Today, the constables, sub-inspectors, officers are working on their own will, and not following the orders of the CM," he said wondering how law and order will be in place in such a situation. "The same officials including IAS, IPS become active on the directives of the Election Commission, but give no ear to the CM," he said adding that the CM himself admitted that corruption exists at police station and tehsil levels. "Like SP and BSP governments the CM is also acting under the influence of a caucus of 5-6 IAS officers at the 'pancham tal," he alleged. On Rahul Gandhi's recent remarks of developing his constituency like California, Rajbhar also took a dig on him and PM Modi. "Whenever elections start approaching near someone wants to make Kyoto like city, some others want to develop cities like California and Singapore. Some others get ready to make temple and mosque. These are only poll gimmicks," he said. He also accused the UP government of deceiving backward class students in providing scholarship and fee reimbursement. "I have raised the issue repeatedly that the government is deceiving the students of backward class. On April 16 an online portal was opened for scholarship and fee reimbursement of SC/ST and general class students only," he said adding that there are about 24 lakh students of SC/ST, general and minority classes, while backward class has 26 lakh students out of whom only 14 lakh have been benefitted with the scholarship and fee reimbursement. "Besides, these are big disparities in providing scholarship and fee reimbursement," he alleged adding that the general and SC students get Rs. 50,000 while backward students of the same class get petty amounts like Rs. 3000 to Rs. 6000 only. Regarding his meeting with BJP president Amit Shah, he said that he put his concerns before Shah demanding immediate measure in this regard. "I suggested categorization in 27% OBC quota into three categories –'pichhada', 'ati pichhada' and 'sarvadhik pichhada' to satisfy them. The BJP president assured me that my demand will be addressed six months before the elections," he said adding that he also demanded the beginning of recruitment process in government jobs only after the division of OBC quota. On Unnao rape, Rajbhar said that the incident earned bad name to the government, though prompt actions like constitution of SIT and handing over the case to CBI were taken. When asked about his views on the ouster of the rape accused BJP MLA Kuldeep Singh Sengar from the party, he said that it is BJP's internal matter. Had any MLA of SBSP made accused in such case, he would have been ousted immediately, said Rajbhar adding, "I am sure that the BJP will oust Sengar shortly".
- Loya death: SC ruling has exposed Congress, says UP CM Yogi Adityanath
Referring to a Congress press conferences and a Rahul Gandhi-led delegation to the President for a probe into Judge Loya's death, the chief minister said the apex court verdict on the issue has exposed the "ugly face" of the Congress.
- Congress: PM Narendra Modi, UP CM Yogi Adityanath don't understand women's pain
PANAJI: The BJP cannot not be expected to deliver justice for rape survivors because Prime Minister Narendra Modi and Uttar Pradesh chief minister Yogi Adityanath, being unmarried, do not understand the pain women feel, said the Goa Pradesh Mahila Congress on Wednesday. The state Congress unit said that BJP leaders lack respect for women, which is why the party remains apathetic towards crimes against women, especially sexual violence. Congress workers carried out a protest march from the Congress house to the Panaji municipal market demanding that Modi resign if he is unable to bring those guilty of sexual crimes to justice. "The number of children who have been raped has increased dramatically and yet, the central government remains silent. Yogi and Modi will never understand the pain of a woman or a young girl because both of them are unmarried and they don't respect women," Goa Pradesh Mahila Congress president Pratima Coutinho said. Congress workers also questioned the silence of senior BJP leaders such as Sushma Swaraj, Hema Malini, Smriti Irani and Uma Bharti on the issue.
- Yogi Adityanath's minister calls Mayawati's rule efficient, but then adds a rider
LUCKNOW: UP cabinet minister Swami Prasad Maurya has stirred a controversy by questioning the efficiency of administration in solving the Unnao rape case and claiming that the governance during previous Mayawati government was 'very efficient'. Maurya had said that the CBI probe in the Unnao rape case involving BJP MLA Kuldeep SiSwami Prasad Mauryangh Senger would not have arisen had the police acted promptly. He said that the former CM Mayawati kept a direct control on executive which worked much efficiently. "Woh abhi prashasan ke liye suvikhyat thi...(She was famous for her administration)'' he said in an interview to a news channel on Tuesday. Even as his statement went viral, the minister on Wednesday came out with a clarification saying that the law and order situation during BSP regime was better than the previous SP government. He also said the ruling BJP government in UP too wants to establish a rule of law just like in case of the previous Mayawati government. "The law and order in BJP government is also good,'' he insisted. Maurya maintained that apart the good governance he had also pointed out the shortcomings of Maya regime. "She was neck deep in corruption," he added. The former BSP national general secretary had joined BJP in June 2016 while accusing Mayawati of drifting away from the principles of BR Ambedkar and selling tickets to party candidates. Earlier, an NDA ally and Suheldev Bhartiya Samaj Party chief Om Prakash Rajbhar — who is also a cabinet mnister in Yogi government — also openly criticised the state government accusing it of being corrupt and failing on the law and order front.
- Dalit Mahasabha head is new SC finance panel chief
LUCKNOW: Less than a week after the Dalit Mahasabha gave chief minister Yogi Adityanath the 'Dalit Mitra' award, its president Lalji Prasad Nirmal was appointed chairperson of the UP Scheduled Caste Finance and Development Corporation on Wednesday. The Mahasabha's decision to award the CM was mired in controversy with some of its founding members objecting to this award, saying that Dalits across the country were being harassed under the BJP regime and the present, of all times, was not the best for giving such an award. The day the award was presented to the CM, on the occasion of Ambedkar Jayanti on April 14, the antiaward members were arrested from outside the presentation venue for carrying out a protest. SR Darapuri, a lifetime member of the Mahasabha, had accused Nirmal of trying to appease the government for personal gains. He said: "Dr Nirmal's announcement for presenting the award to the CM was not on behalf of the Mahasabha. When Dalits are being harassed by BJP governments, why is he giving an award to a BJP CM? After the all-India protest by Dalits on April 2, where outsiders joined our rallies and tried to malign the movement by indulging in violence, the government has taken action was taken against Dalits. In UP, an ex-MLA in Meerut was framed while several Dalit boys were arrested," Darapuri said. Brushing aside the internal rebellion as spurred by political forces, Nirmal on April 14 also announced that the next Dalit Mitra award would be given to Prime Minister Narendra Modi.
- Post-Unnao, UP proposes death for minor's rape
LUCKNOW: Facing flak for mishandling of the alleged Unnao rape case, the UP government has decided to send a proposal to the Centre seeking a provision to award death penalty to rapists in cases of assault on minors. Earlier, J&K chief minister Mehbooba Mufti and Union minister Maneka Gandhi proposed a law to make death penalty mandatory for those who violate minors. Delhi CM Arvind Kejriwal, too, has announced his plan to introduce death penalty for rapists of minor girls. Chief minister Yogi Adiytanath tweeted from his official handle that the government was sending the proposal to the Centre 'for an amendment in the law to award death penalty to those found guilty of raping a minor'. Holding a review meeting with top administrative and police officials earlier on Wednesday evening, the CM asked officials to step up efforts to ensure safety of women in the state. Yogi asked police officials to strengthen initiatives they had introduced to tackle crime against women such as 1090 (Women Powerline) and UP-100. Yogi emphasized before officials that the Unnao case would not have had such ramifications had the local police did their job last year in June. Yogi directed officials to fix responsibility of police personnel from the level of beat constable to that of district police superintendent. Yogi emphasized that supervisory officers from the level of sub-divisional magistrates and deputy SPs carry out foot patrolling in their areas to give people a sense of safety. In a separate meeting held by the chief secretary earlier, directions were issued to commissioners and DIGs posted in the state to improve law and order situation through joint patrolling.
- UP wants death penalty for raping minor
Lucknow: Facing flak for mishandling the alleged Unnao rape case, the UP government has decided to send a proposal to the Centre seeking a provision to award death penalty to rapists in cases of assault on minors. Earlier, J&K chief minister Mehbooba Mufti and Union minister Maneka Gandhi had proposed a law to make death penalty mandatory for those who violate minors. MP, Rajasthan, Haryana and Arunachal Pradesh have already passed bills in their respective state assemblies to award death penalties in similar crimes. Delhi CM Arvind Kejriwal too has announced his plan to introduce death penalty for rapists of minor girls. CM Yogi Adiytanath tweeted that the government was sending the proposal to the Centre for an amendment in the law for the purpose. Holding a review meet with top administrative and police officials earlier on Wednesday, the CM asked officials to step up efforts to ensure safety of women in the state. Yogi asked officers to strengthen initiatives introduced to tackle crime against women such as 1090 (Women Powerline) and UP-100.
- Unnao effect: UP govt to write to Centre seeking death penalty for rapists
LUCKNOW: The Uttar Pradesh government will ask the Centre to amend existing laws to ensure death penalty to rapists, chief minister Yogi Adityanath said on Wednesday. "It is necessary that rapists get strict punishment. We are going to send a letter to the Centre to make necessary amendments to award capital punishment to rapists," Adityanath said according to a release issued here. The comments, made in a meeting called to review law and order, come in the backdrop of a massive outrage over Unnao and Kathua cases. A BJP MLA, Kuldeep Singh Sengar, stands accused of rape in Unnao in UP while a minor was allegedly killed after being raped in Kathua in J&K. Adityanath said the state government has a zero tolerance policy against crime. "From beat constable to the SP --all should be made accountable and answerable. The senior officials should keep an eye and ensure immediate action against those found guilty of laxity," he said. The chief minister emphasised that crime against women should be checked and 1090 women power line should be strengthened and the 'anti-romoeo squads' should also be associated with them. "The police should also do foot patrolling and establish dialogue with people. Those having dubious past should not be made SHOs," he said.
- Chinmayanand case: Survivor says ex-min forged affidavit claiming she wanted to take back case
The woman who was allegedly raped by former Union minister Swami Chinmayanand has now lodged a complaint with additional director general alleging that the ex-minister and his aides have forged an affidavit in which she has "agreed" to withdraw the case against them.
- Crime branch nabs thief, seizes phones worth Rs 75,000
NASHIK: The city police on Monday arrested a man who allegedly used to steal mobile phones of train and bus passengers. Police also recovered five mobile phones worth Rs 75,000 from him. The suspect is identified as Anil Ramdas Turkane who is hailing from Lakhganga in Aurangabad district and is staying at Shantinagar in Ambad. The crime branch officers said following instructions from senior officers they were in search of criminals who were stealing mobile phones of bus passengers. On Monday, they received a tip that Turkane, who stole mobile phones from rail passengers at Nashik Road railway station and bus passengers at Mela bus stand, was coming to the Thakkar Bazaar area to sell the phones. Subsequently, inspector Ananda Wagh laid a trap and arrested Turkane. During interrogation, Turkane admitted to stealing phones from the said places. Cases about the theft are registered with the Nashik Road railway police station and Sarkarwada police station. The suspect has been handed over to the Sarkarwada police for further investigation, said crime branch officials.
- Grand Odisha Day celebrations in Lucknow
Odisha Day was celebrated in a grand way at Sangeet Natak Academy, recently. Organised by Government of UP, in association with Ayodhya Research Institute and Oriya Samaj, chief guests Ram Naik, governor, UP and UP CM Yogi Adityanath, inaugurated the event and praised the efforts of Orissa government in promoting their art and culture. The highlight of the event was a classical performance by artists who came from Malaysia. Under the guidance of Padma Shri Ramli Ibrahim, the artist performed Mangalacharan, Sthai, Navrasa, Rama Bhajana and Yogini-Moksha. Apart from the cultural performances,the visitors also got to taste Odisi food at the Oriya Food Festival organised at the event. — By Adnaan Rizvi Ram Naik and Yogi Adityanath (BCCL/ Vishnu Jaiswal) Awanish Awasthi, Linda Bui and Victoril Kraknes (BCCL/ Vishnu Jaiswal) (L-R) Kamilla Olsen, Lna Bustavsen & Silue Edvardsen (BCCL/ Vishnu Jaiswal) (L-R) Silje Gjertsen, Kaja Widdop and Vibeke Tangen (BCCL/ Vishnu Jaiswal) (L-R) DR Sahu, GB Pattanaik and Sivangi Singh (BCCL/ Vishnu Jaiswal) Shweta Patnaik (R) Usha and Nidhi (BCCL/ Vishnu Jaiswal)
- UP recalled NIA cop before tenure
LUCKNOW: IPS officer of UP cadre Pratibha Ambedkar, who was supervising the Mecca Masjid blast case as NIA superintendent of police, was recalled by the Yogi Adityanath government just two weeks before the verdict. TOI has accessed the relieving letter dated April 6 issued by the NIA to the 2007 batch officer. Ambedkar had five months to complete her fouryear tenure at the NIA office in Hyderabad. On Monday, a special NIA court acquitted all five accused including Swami Aseemanand in the case, triggering a debate between the BJP and the Congress on the "saffron terror" narrative. Nine people had died and 58 injured in the blast during Friday prayers at the mosque on May 18, 2007. The letter sent by the administration wing of NIA was sent following a March 6 request from the BJP government that cited "vast experience" as the reason for Ambedkar to be repatriated to UP cadre. The NIA in its order stated that Ambedkar will report to the DGP of Uttar Pradesh. "In continuation to this office order dated April 3, the competent authority has sanctioned 60 days earned leave in favour of Pratibha Ambedar, superintendent of police, NIA, with effect from April 7, 2018 with permission to avail suffix, if any, with her repatriation," said the letter from SN Pandey, superintendent of police (administration) at NIA headquarters in Delhi.
- CM Yogi Adityanath directs night chaupals in villages
LUCKNOW: To ensure smooth implementation of the Gram Swaraj Abhiyan, the government has directed district magistrates, divisional commissioners and other officials from the administration to spend nights at various villages where the government is implementing the central government scheme. Chief minister Yogi Adityanath has instructed officials to organize chaupals across the identified villages at night and make arrangements to stay on so that they may be able to initiate dialogue with locals and inform them better about the various state and Central government schemes they can benefit from. "The idea of the 'ratri chaupal' or chaupal at night came about because villagers are often busy in the fields during the day. It is only at night, when they come back that officers will be able to address them collectively. Since we have been given directions to invite MPs, MLAs, and other public representatives for all the functions, even they should be spending the night at villages. However, we have so far not received any request to make arrangements for a VIP stay anywhere," said the DM of an eastern UP city. A divisional commissioner said that for the next almost three weeks, officials would be largely occupied with this programme. "This is not all that we are expected to do but yes, it is going to take up most of our time. There is a huge list of villages that we have to go to and ensure participation in the government schemes. During the abhiyan, which started on April 14 and will continue till May 5, there are seven central government schemes and a few of the state government's that we have to publicise and encourage people to participate in. Other than this, there are some special days that are being observed. For instance, Swachh Bharat Abhiyan on April 18 during which extra activities have been planned," he said.
- Rahul Gandhi ducks questions on state of Amethi, blames PM Modi, CM Yogi
AMETHI: Assuring the people of his constituency, Congress president Rahul Gandhi said on Tuesday that his commitment for Amethi will stay intact whether he remains an MP or not. The Amethi MP, however, ducked the questions of some girl students of Brightway School at Rasta Mau. "Government makes laws but why are they not implemented in our village?" a girl asked. Rahul ducked the question, saying, "Yeh aap Modi ji se poochhiye.. meri sarkar thodi hi hai. Jab hamari sarkar hogi toh humse poochhiyega (You ask this question to Prime Minister Narendra Modi. It's not my government. You ask me this question when Congress comes to power)." Dissatisfied with the reply, when the girl countered saying that she was talking about Amethi, Rahul put the blame on UP chief minister Yogi Adityanath. "Yogiji runs Amethi now. I am an MP. My job is to make laws in Lok Sabha," he said. Attacking Yogi, Rahul said, "Yogi ji ka kaam UP ko chalane ka hai, par woh doosre kaam kar rahe hain... bijli ka kaam nahi kar rahe hain, pani ka kaam nahi kar rahe hain, shiksha ka kaam nahi kar rahe hain... bas krodh phaila rahe hain... jisse dange ho rahe hain, aatank phail raha hai (It's Yogiji's job to run UP but he is busy elsewhere. He is not working to ensure electricity, water supply, education. He is only spreading hatred which is causing riots, spreading fear)." The interaction, that took place on the first day of his visit to Amethi, also found mention in Rahul's speech later in the day. Addressing a gathering, Rahul said, "Girls in a school asked some very pertinent questions to me. And I feel that children are our future." Rahul urged children to stand up against rising hatred. "Whenever you come across anyone you feel is spreading hatred, walk up to them, stare into their eyes and tell them that you are the future of the country and that no one one can play with your future. India will grow with love and communal amity and stop dividing the country," he said.
- DDU University cancels exams after paper leak
GORAKHPUR: Gorakhpur University on Tuesday cancelled two exams after question papers of them made it to social media hours before the start of exams. Authorities at Deen Dayal Upadhyay Gorakhpur University are yet to announce fresh dates for the BSc-I mathematics and BA-II social work exams. Reports said that chief minister Yogi Adityanath has taken a serious note of the incident. The university has begun the process of filing an FIR against unidentified people. It has also written to the district magistrates and superintendents of police of the districts concerned, seeking attention to the incident. The new dates for the exams will decided on April 19, a university official said. Meanwhile, some students protested at the vicechancellor's office and demanded removal of the examination controller from his post. On Monday, the two papers—scheduled for Tuesday-—became viral on social media. The mathematics exam was scheduled for morning while social work was scheduled for afternoon. A committee under pro-VC SK Dixit found in its initial investigation that while the mathematics paper was leaked, the social work one did not match the actual examination paper."Some miscreants tried to create hindrance by circulating the papers on social media. The viral paper of sociology was based on previous years' papers whereas the mathematics paper matched with the actual paper and it was reported to be leaked. The university didn't take any risk and decided to cancel both papers," said university spokesperson Prof Harsh Sinha. "The process of FIR against unidentified miscreants has been initiated," Sinha added. On the demand by protesting students, he said, "The university has taken the decision of cancellation of papers in favour of students. The VC has appealed to students to be patient and assured them of strict action against the culprits."
- 'Doccuments fake, didn't drop rape case'
SHAHJAHANPUR: The woman who was allegedly raped by former Union minister Swami Chinmayanand has now lodged a complaint with additional director general alleging that the ex-minister and his aides have forged an affidavit in which she has "agreed" to withdraw the case against them. This comes days after the Yogi Adityanath government decided to withdraw the 2011 rape and abduction case lodged against him in Shahjahanpur. That decision did not cite a reason for withdrawal. In her complaint filed on the integrated grievance redress system (IGRS), popularly known as Jansunwai portal, she said if her charges were found to be true, another FIR should be filed against Chinmayanand and his aides. The survivor told TOI, "I hope that the complaint filed by me on IGRS is taken seriously and if my allegations are true then an FIR should be filed against Chinmayanand and his aides." Claiming threat to her life from the former minister, she said, "I have serious threat from Chinmayanand and his aides. They can attack me or my minor child anytime. I want this case to be transferred out of the state." Despite many attempts, the former minister was not available for his comment. In her 2011 complaint, the woman had alleged that she was kept at an ashram in Haridwar and raped by the former minister. Her father had lodged an FIR against him at Kotwali police station in Shahjahanpur. However, Chinmayanand moved high court, which had stayed his arrest. The case is pending. On March 9, Shahjahanpur administration wrote to the prosecution officer of the case for the withdrawal of the case. The note did not cite any reason. Chinamayananand has been a three-time BJP MP, having won from Badaun (1991), Machchlishahr (1998) and Jaunpur (1999). He was made MoS for internal security in Atal Bihari Vajpayee government.
- UP Govt raises e-tender ceiling to Rs 10 lakh
LUCKNOW: In view of reports of inconvenience in the tendering process, the state government raised the ceiling for e-tenders to Rs 10 lakh on Tuesday. After this, local tenders could be issued for any government job worth less than Rs 10 lakh. This is the second revision since the scheme was launched by the Yogi Adityanath government in May 2017 with Rs 1-lakh ceiling to check corruption. The last time a revision took place was on March 27, 2018 when the ceiling was raised from Rs 1lakh to Rs 5 lakh. The decision was taken during a cabinet meeting held on Tuesday. Officials said that the change was made because after the implementation of Rs 1lakh ceiling rule last year, some departments had said that they were facing inconveniences in implementation. Interestingly, this was the same reason cited when the ceiling was raised less than a month earlier from 1 lakh to 5 lakh.


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Fachbereich Chemie
- Englisch (52) (entfernen)
- cobalt (3)
- Clusterion (2)
- Infrarotspektroskopie (2)
- Microarray (2)
- Protonentransfer (2)
- deuteration (2)
- dipeptide (2)
- enamide (2)
- gas phase (2)
- Establishment and Application of Methods for the Detection of DNA and Protein Adducts from Tobacco-Specific Nitrosamines and Benzo[a]pyrene (2002)
- Lung cancer, mainly caused by tobacco smoke, is the leading cause of cancer mortality. Large efforts in prevention and cessation have reduced smoking rates in the U.S. and other countries. Nevertheless, since 1990, rates have remained constant and it is believed that most of those currently smoking (~25%) are addicted to nicotine, and therefore are unable to stop smoking. An alternative strategy to reduce lung cancer mortality is the development of chemopreventive mixtures used to reduce cancer risk. Before entering clinical trails, it is crucial to know the efficacy, toxicity and the molecular mechanism by which the active compounds prevent carcinogenesis. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N-nitrosonornicotine (NNN) and benzo[a]pyrene (B[a]P) are among the most carcinogenic compounds in tobacco smoke. All have been widely used as model carcinogens and their tumorigenic activities are well established. It is believed that formation of DNA adducts is a crucial step in carcinogenesis. NNK and NNN form 4-hydroxy-1-(3-pyridyl)-1-butanone releasing and methylating adducts, while B[a]P forms B[a]P-tetraol-releasing adducts. Different isothiocyanates (ITCs) are able to prevent NNK-, NNN- or B[a]P-induced tumor formation, but relative little is know about the mechanism of these preventive effects. In this thesis, the influence of different ITCs on adduct formation from NNK plus B[a]P and NNN were evaluated. Using an A/J mouse lung tumor model, it was first shown that the formation of HPB-releasing, O6-mG and B[a]P-tetraol-releasing adducts were not affected when NNK and B[a]P were given individually or in combination, of by gavage. Using the same model, the effects of different mixtures of PEITC and BITC, given by gavage or in the diet, on DNA adduct formation were evaluated. Dietary treatment with phenethyl isothiocyanate (PEITC) or PEITC plus benzyl isothiocyanate (BITC) reduced levels of HPB-releasing adducts by 40*50%. This is consistent with a previously shown 40% inhibition of tumor multiplicity for the same treatment. In the gavage treatments with ITCs it seemed that PEITC reduced HPB-releasing DNA adducts, while levels of BITC counteracted these effects. Levels of O6-mG were minimally affected by any of the treatments. Levels of B[a]P-tetraol releasing adducts were reduced by gavaged PEITC Summary Page XII and BITC, 120 h after the last carcinogen treatment, while dietary treatment had no effects. We then extended our investigation to F-344 rats by using a similar ITC treatment protocol as in the mouse model. NNK was given in the drinking water and B[a]P in diet. Dietary PEITC reduced the formation of HPB-releasing globin and DNA adducts in lung but not in liver, while levels of B[a]P-tetraol-releasing adducts were unaffected. Additionally, the effects of PEITC, 3-phenlypropyl isothiocyanate, and their N-acetylcystein conjugates in diet on adducts from NNN in drinking water were evaluated in rat esophageal DNA and globin. Using a protocol known to inhibit NNNinduced esophageal tumorigenesis, the levels of HPB-releasing adduct levels were unaffected by the ITCs treatment. The observations that dietary PEITC inhibited the formation of HPB-releasing DNA adducts only in mice where the control levels were above 1 fmol/µg DNA and adduct levels in rat lung were reduced to levels seen in liver, lead to the conclusion that in mice and rats, there are at least two activation pathway of NNK. One is PEITC-sensitive and responsible for the high adduct levels in lung and presumably also for higher carcinogenicity of NNK in lung. The other is PEITC-insensitive and responsible for the remaining adduct levels and tumorigenicity. In conclusion, our results demonstrated that the preventive mechanism by which ITCs inhibit carcinogenesis is only in part due to inhibition of DNA adduct formation and that other mechanisms are involved. There is a large body of evidence indicating that induction of apoptosis may be a mechanism by which ITCs prevent tumor formation, but further studies are required.
- Immunotoxins and Neurotrophins: Novel Strategies for the Efficient Expression of Recombinant Proteins (2002)
- The development of recombinant DNA techniques opened a new era for protein production both in scientific research and industrial application. However, the purification of recombinant proteins is very often quite difficult and inefficient. Therefore, we tried to employ novel techniques for the expression and purification of three pharmacologically interesting proteins: the plant toxin gelonin; a fusion protein of gelonin and the extracellular domain of the subunit of the acetylcholine receptor (gelonin-AchR) and human neurotrophin 3 (hNT3). Recombinant gelonin, acetylcholine receptor a subunit and their fusion product, gelonin-AchR were constructed and expressed. The gelonin gene, a 753 bp polynucleotide was chemically synthesized by Ya-Wei Shi et al. and was kindly provided to us. The gene was first inserted into the vector pUC118 yielding pUC-gel. It was subsequently transferred into pET28a and pET-gel was expressed in E. coli. The product, gelonin was soluble and was purified in two steps showing a homogeneous band corresponding to 28 kD on SDS-PAGE. The expression of the extracellular domain of the -subunit of AchR always led to insoluble aggregates and even upon coexpression with the chaperonin GroESL, very small and hardly reproducible amounts of soluble material were formed, only. Therefore, recombinant AchR- gelonin was cloned and expressed in the same host. The corresponding fusion protein, gelonin-AchR, again formed aggregates and it had to be solubilized in 6 M Gu-HCl for further purification and refolding. The final product, however, was recognized by several monoclonal antibodies directed against the extracellular domain of the -subunit of AchR as well as a polyclonal serum against gelonin. Expression and purification of recombinant hNT3 was achieved by the use of a protein self-splicing system. Based on the reported hNT3 DNA sequence, a 380 bp fragment corresponding to a 14 kD protein was amplified from genomal DNA of human whole blood by PCR. The DNA fragment was cloned into the pTXB1 vector, which contains a DNA fragment of intein and chintin binding domain (CBD). A further construct, pJLA-hNT3, is temperature-inducible. Both constructs expressed the target protein, hNT3-intein-CBD in E. coli by the induction with IPTG or temperature, however, as aggregates. After denaturation and renaturation, the soluble fusion protein was slowly loaded on an affinity column of chitin beads. A 14 kD hNT3 could be isolated after cleavage with DTT either at 4 °C or 25 °C for 48 h. Based on nerve fiber out-growth of the dorsal root ganglia of chicken embryos, both, hNT-3-intein-CBD and hNT3 itself exhibit almost the same biological activity.
- Chemistry of Mircrosolvated Metal Ions (2003)
- Clusters bridge the gap between single atoms or molecules and the condensed phase and it is the challenge of cluster science to obtain a deeper understanding of the molecular foundation of the observed cluster specific properties/reactivities and their dependence on size. The electronic structure of hydrated magnesium monocations [Mg,nH2O]+, n<20, exhibits a strong cluster size dependency. With increasing number of H2O ligands the SOMO evolves from a quasi-valence state (n=3-5), in which the singly occupied molecular orbital (SOMO) is not yet detached from the metal atom and has distinct sp-hybrid character, to a contact ion pair state. For larger clusters (n=17,19) these ion pair states are best described as solvent separated ion pair states, which are formed by a hydrated dication and a hydrated electron. With growing cluster size the SOMO moves away from the magnesium ion to the cluster surface, where it is localized through mutual attractive interactions between the electron density and dangling H-atoms of H2O ligands forming "molecular tweezers" HO-H (e-) H-OH. In case of the hydrated aluminum monocations [Al,nH2O]+,n=20, different isomers of the formal stoichiometry [Al,20H2O]+ were investigated by using gradient-corrected DFT (BLYP) and three different basic structures for [Al,20H2O]+ were identified: (a) [AlI(H2O)20]+ with a threefold coordinated AlI; (b) [HAlIII(OH)(H2O)19]+ with a fourfold coordinated AlIII; (c) [HAlIII(OH)(H2O)19]+ with a fivefold coordinated AlIII. In ground state [AlI(H2O)20]+ (a) which contains aluminum in oxidation state +1 the 3s2 valence electrons remain located at the aluminium monocation. Different than for open shell magnesium monocations no electron transfer into the hydration shell is observed for closed shell AlI. However, clusters of type (a) are high energy isomers (DE»+190 kJ mol-1) and the activation barrier for reaction into cluster type (b) or (c) is only approximately 14 kJ mol-1. The performed ab initio calculations reveal that unlike in [Mg,nH2O]+, n=7-17, for which H atom eliminiation is found to be the result of an intracluster redoxreaction, in [Al,nH2O]+,n=20, H2 is formed in an intracluster acid-base reaction. In [Mg,nH2O]+, n>17, the magnesium dication was found to coexist with a hydrated electron in larger cluster sizes. This proves that intermolecular electron delocalization - previously almost exclusively studied in (H2O)n- and (NH3)n- clusters - can also be an important issue for water clusters doped with an open shell metal cation or a metal anion. Structures and stabilities of hydrated magnesium water cluster anions with the formal stoichiometry [Mg,nH2O]-, n=1-11, were investigated by application of various correlated ab initio methods (MP2, CCSD, CCSD(T)). Metal cations surely have high relevance in numerous biological processes, and as most biological processes take place in aqueous solution hydrated metal ions will be involved. However, in biological systems solvent molecules (i.e. water) compete with different solvated chelate ligands for coordination sites at the metal ion and the solvent and chelate ligands are in mutual interactions with each other and the metal ion. These interactions were investigated for the hydration of ZnII/carnosine complexes by application of FT-ICR-MS, gas-phase H/D exchange experiments and supporting ab initio calculations. In the last chapter of this work the Free Electron Laser IR Multi Photon Dissocition (FEL-IR-MPD) spectra of mass selected cationic niobium acetonitrile complexes with the formal stoichiometry [Nb,nCH3CN]+, n=4-5, in the spectral range 780 – 2500 cm-1 are reported. In case of n=4 the recorded vibrational bands are close to those of the free CH3CN molecule and the experimental spectra do not contain any evident indication of a potential reaction beyond complex formation. By comparison with B3LYP calculated IR absorption spectra the recorded spectra are assigned to high spin (quintet, S=2), planar [NbI(NCCH3)4]+. In [Nb,nCH3CN]+, n=5, new vibrational bands shifted away from those of the acetonitrile monomer are observed between 1300 – 1550 cm-1. These bands are evidence of a chemical modification due to an intramolecular reaction. Screening on the basis of B3LYP calculated IR absorption spectra allow for an assignment of the recorded spectra to the metallacyclic species [NbIII(NCCH3)3(N=C(CH3)C(CH3)=N)]+ (triplet, S=1), which has formed in a internal reductive nitrile coupling reaction from [NbI(NCCH3)5]+. Calculated reaction coordinates explain the experimentally observed differences in reactivity between ground state [NbI(NCCH3)4]+ and [NbI(NCCH3)5]+. The reductive nitrile coupling reaction is exothermic and accessible (Ea=49 kJ mol-1) only in [NbI(NCCH3)5]+, whereas in [NbI(NCCH3)4]+ the reaction is found to be endothermic and retarded by significantly higher activation barriers (Ea>116 kJ mol-1).
- In vivo and in vitro studies on heavy doses and fluorescent-labelled vitamin C using ESR and fluorescence spectroscopy (2005)
- Under physiological conditions oxygen is constantly being converted to reactive oxygen intermediates, in mitochondria, peroxisomes, cytochrome p450 systems, macrophages, neutrophils and in plasma membranes. These reactive oxygen species (ROS) are toxic and therefore alter cell integrity leading to cell damage. To protect itself against this toxic effect of ROS, living systems have developed defence systems that scavenge ROS formation. These systems include some enzymes, transporting proteins and small antioxidant molecules for instance vitamin C and E. This thesis describes a study on the antioxidant chemistry and activity of vitamin C in vivo and in vitro systems using ESR spectroscopy. Also, a new method was designed to label ascorbic acid with a fluorescent marker. Moreover, some important criteria were considered for the evaluation and quantification of ascorbyl radicals in human blood plasma using two types of ESR spectrometers.
- Mechanisms of the 3- hydroxyl-3-methylglutaryl-coenzyme a reductase inhibitor- induced myotoxicity in human skeletal muscle cell cultures (2005)
- The HMG-CoA reductase inhibitors SIM, LOV, ATV, PRA, FV and NKS were investigated for their effects on human SkMCs. We were able to demonstrate that statins can induce oxidative stress (ROS formation, GSH-depletion, TBARS), apoptosis (, caspase-3 activity, nuclear morphology) and necrosis (LDH-leakage) in hSkMCs. After incubation with statins, the sequence of cellular events starts by the increased formation of ROS (30 min) followed by caspase-3 activation (2-4 hours) and necrosis (LDH-leakage) and formation of condensed and fragmented nuclei after 24-72 hours. It was shown that, antioxidants (NAC, DTT, TPGS, M-2 and M-3) and the HMG-CoA reductase downstream metabolites (MVA, F, FPP, GG and GGPP) protected against statin-induced ROS formation, caspase-3 activation and partially from necrosis. The caspase-3 inhibitor Ac-DEVD-CHO rescues cells partially from necrosis. These results suggest that the statin-induced necrosis is HMG-CoA dependent and occurs secondary to apoptosis, which by decrease of ATP is driven into necrosis. The increase of ATP observed at low concentrations and early time points suggest an increased glycolytic activity. This was confirmed by increased PDK-4 gene expression and increased PFK2/F-2,6-BPase expression both activator of glycolysis. Glycolysis was also confirmed for some statins by increased cellular lactate concentations. The consequence of PDK-4 mediated pyruvate dehydrogenase inactivation is the metabolic switching from fatty acid to amino acid from proteins as energy source. The oxidative stress hypothesis was further supported by the induction of the FOXO3A transcription factor, which is involved in regulating MnSOD-2 expression in the mitochondrium. The mechanism by which statins produce ROS is still not resolved. There is an indirect evidence from our experiments as well as from the literature, that immediately after the statin treatment, intracellular Ca2+ is mobilized due to HMG-CoA reductase inhibition, which after mitochondrial uptake could lead to increased ROS formation.
- Photochromic Switches on Polyolefin Catalysts (2005)
- Metallocenes containing diarylethene type photochromic switches are synthesized, characterized and tested in polyolefin catalysts. Propylene polymerizations using unbridged bis(2,3-dibenzo[b]thiophen-3-yl)cyclopenta[b]thien-3-yl)zirconium dichloride/MAO (80) treated with 254nm UV irradiation produced bimodal polymer distributions by GPC. This was due to an increase in the low molecular weight fractions when the closed form of the catalyst/photoswitch was made. Comparison with similarly structured catalyst without photoisomerization properties did not produce bimodal polymer under identical conditions. Propylene polymerizations made with dimethylsilyl[(1,5-dimethyl-3-phenylcyclopenta[b]thien-6-yl)][(2,3-dibenzothien-3-yl)cyclopenta[b]thien-6-yl)]zirconium dichloride/MAO (86) with 254nm UV irradiation caused a 3 fold increase in the polymer molecular weight. Polymers made with ethylene and ethylene/hexene using (80) after UV irradiation did not show differences in measured polymer properties. Polymerizations with ethylene/ hexene mixtures using (86) had increased activity and co-monomer (hexene) incorporation with UV irradiation.
- Structure and Bonding Studies of Paramagnetic Metallocenes and Their Adducts of d- and f-block metals (2005)
- Sterisch anspruchsvolle Cyclopentadienyl-Liganden wurden zur Stabilisierung neuer Mono(cyclopentadienyl) Verbindungen der schweren Erdalkalimetalle eingesetzt und deren Funktionalisierbarkeit dieser Spezies wurde exemplarisch durch die Synthese neutraler Tripeldecker-Sandwichkomplexe demonstriert. Die dabei ausgebildeten Molekülstrukturen lassen sich mittels DFT-Rechnungen zuverlässig vorhersagen. In diesem Zusammenhang wurde ebenfalls der Cyclononatetraenyl-Ligand, dessen Komplexeigenschaften bisher nur unzureichend untersucht wurden, eingesetzt. Im Rahmen dieser Arbeit gelang die Synthese des Bis(cyclononatetraenyl)bariums, Ba(C9H9)2, und dessen spektroskopische Charakterisierung. DFT-Rechnungen sagen für diesen Komplex eine Metallocenstruktur mit nahezu parallelen Ringen und einem Ba-Ring Abstand von 2.37 Å voraus. Durch den Einsatz des Tetraisopropylcyclopentadienyl (4Cp) und Tri(tert.-butyl)cyclopentadienyl (Cp')-Liganden gelang die Synthese von Bis- und Monocyclopentadienyl-Verbindungen der frühen und späten Lanthanoide. Besonders interessant in diesem Zusammenhang ist die erfolgreiche Darstellung des Azido-Clusters, [Na(dme)3]2[4Cp6Yb6(N3)14] (4Cp= (Me2CH)4C5H), der die unterschiedlichen Koordinationsmöglichkeiten des Azido-Liganden in einem einzigen Komplex vereint. Vergleichbare Komplexe waren in der Organolanthanoidchemie bisher unbekannt. Durch Substitution am Cyclopentadienyl-System lassen sich dessen elektronische und sterische Eigenschaften signifikant verändern. Die Auswirkungen dieser Effekte können sehr eindrucksvoll an Manganocen-Komplexen demonstriert werden, in denen sich der low- und high-spin Zustand energetisch nur sehr wenig unterscheiden. Der elektronische Grundzustand einer Reihe unterschiedlich substituierter Manganocen-Komplexe wurde mittels Festkörpermagnetismus, ESR, Röntgenstrukturanalyse, EXAFS und variabler Temperatur UV-Vis Spektroskopie bestimmt, und mit dem Substitutionsmuster am Cyclopentadienyl-System korreliert. Spin-Gleichgewichte ließen sich für [(Me3C)C5H4]2Mn, [(Me3C)2C5H3]2Mn und [(Me3C)(Me3Si)C5H3]2Mn nachweisen. Theoretische Rechnungen postulieren, dass Cerocen, Ce(C8H8)2, ein Beispiel für Moleküle mit gemischt-konfiguriertem Grundzustand sei, der durch 80 % [(Ce)f1e2u(cot)e2u3] und 20 % [(Ce)f0e2u(cot)e2u4] beschreiben werden könne. Obwohl dieses Molekül bereits seit 1976 bekannt ist, ist dessen elektronische Struktur bis heute sehr umstritten. Im Rahmen dieser Arbeit wurden neue Synthesekonzepte für diese Verbindung entwickelt und die elektronische Struktur mittels magnetischer Messungen im Festkörper, EXAFS und XANES Studien untersucht. Die dabei erhaltenen Daten sind in sehr guter Übereinstimmung mit den theoretischen Rechnungen und belegen die Bedeutung eines gemischt-konfigurierten Grundzustandes bei der Bindung in Organometallkomplexen der f-Block Metalle. Während in Cerocen nur ein temperaturunabhängiger Paramagnetismus (TIP) beobachtet werden kann, findet man eine starke Temperaturabhängigkeit der magnetischen Suszeptibilität in Ytterbium Systemen des Typs Cp'2Yb(bipy') [Cp´ und bipy´ sind substituierte Cyclopentadienyl- oder 4,4'-substituierter 2,2'-Bipyridyl-Liganden]. Temperaturabhängige XANES-Experimenten belegen, dass auch in diesen Systemen ein gemischt-konfigurierter Grundzustand vorliegt, der durch [(Yb)f14(bipy)b1()0] und [(Yb)f13(bipy)b1()1] beschreiben werden kann. Der relative Anteil beider Wellenfunktionen zum Grundzustand wird durch Substitution am 2,2'-Bipyridyl- oder Cyclopentadienyl-System signifikant beeinflusst. Modelle, mit denen sich dieses Verhalten qualitativ beschreiben lässt, wurden im Rahmen dieser Arbeit entwickelt. Ein kinetisch stabilisiertes, adduktfreies Titanocen wurde unter Verwendung des Di(tert.-butyl)cyclopentadienyl Liganden hergestellt und dessen Reaktivität gegenüber kleinen Molekülen, z.B. CO, N2 und H2 untersucht. Im Rahmen der Reaktivitätsstudien wurden ebenfalls 2,2'-Bipyridyl Addukte an das Cp'2Ti Fragment synthetisiert und deren magnetische Eigenschaften erforscht. Durch Variationen am 2,2'-Bipyridyl System lässt sich das Singlet-Triplet Splitting in diesem System gezielt steuern.
- Functional Characterization of Mitochondrial Uncoupling Protein 2 by EPR Studies (2006)
- Uncoupling protein1 (UCP1) in brown adipose tissue was discovered earlier as the main uncoupling source of respiration. We describe the basic facts and a modest contribution of our group to the area of research on mitochondrial uncoupling proteins. After defining the terms uncoupling, leak, proton-mediated uncoupling, we discuss the assumption that due to its low abundance, uncoupling protein 2 (UCP2) can provide only mild uncoupling, i.e. can decrease the proton motive force by several mV only. A fatty acid cycling mechanism is described as a plausible explanation for the protonophoretic function of all uncoupling proteins together with our experiments supporting it. A speculation for the phylogenesis of all uncoupling proteins can be deduced by estimated UCP2 content in several tissues, and details of its activation are explained on the basis of our experiments. In the present study a solubilization and refolding method for UCP2 from inclusion bodies was developed and characterized. As it was known and also demonstrated from previous experiments on UCP1 that fatty acids are substrates, we used the same procedure to study the function of UCP2. Utilizing spin-labelled fatty acids (SLFA) for our experiments we demonstrated the binding of fatty acids to UCP2, and the competition of other natural fatty acids like oleic acid, palmitic acid, arachidonic acid and eicosatrienoic acid to the preformed complex emphasizes the presence of a fatty acid binding site for mitochondrial UCP2. The findings were observed by EPR spectroscopy where the highly immobilized spectra with presence of spin-labelled fatty acid eventually end up as free spin label spectra with a particular concentration of the natural fatty acid added to the UCP2 bound with spin-labelled fatty acid. This fits in significantly with the earlier findings of UCP1 and also leads to assumption of functional explanation about the physiological relevance between the uncoupling proteins functions. The present study, in which representative and sensitive parameters for EPR spectroscopy were established, at the same time describes the concentration effects of fatty acids upon the protein bound with spin-labelled fatty acids which are much of importance in comparison to physiological levels, being in the micromolar range (µM) as compared with milli molar (mM) as for UCP1 previously. In appropriate examples, different fatty acids are used and compared with competitors like alkylsulfonates also emphasizing the function of the protein. And the studies with the effect of nucleotides inhibition demonstrate that there exists a putative binding site for fatty acids. Much significance lies in demonstration with the spin-labelled-ATP studies where competition of ATP to the protein bound to spin-labelled ATP explains about the inhibition effect of nucleotides on the UCP2. So the present study applies different methods for the functional characterization of UCP2. The studies of natural fatty acids and alkylsulfonates with UCP2 bound to spin-labelled fatty acid, and study of nucleotide inhibition on UCP2 are closely related and give the much awaited answer to the question of functional similarities between UCP1 and UCP2. This supports the discussion of many groups which predict the functional similarity between these two proteins based upon sequence homology. Also many attempts have been reported in literature to explain the physiological functional relevance where by this present study can also be added to as we now suppose from the present conclusions of our experiments.
- Effect of selected Flavonoids and Polyphenols on Key Elements involved in the Regulation of the Glucose/Glycogen Homeostasis and the Wnt Signalling Pathway (2008)
- Colorectal cancer is the second most prevalent cancer form in both men and women in the Europe. In 2002, alimentary cancer (oesophagus, stomach, intestines) made up 26% of the annual incident cases of cancer amongst males in Europe, whereby about half of those were cancers of the colon and rectum (Eurostat 2002). Epidemiological evidence accumulating over the last decades indicates that besides a genetic disposition, diet plays a strong epigenetic role in the genesis of cancer. It is generally assumed that diet is causal for up to 80% of colorectal cancer (Bingham 2000). With the prospect of an approximated 50% rise in global cancer incidence over the first two decades of the 21st century, the World Health Organisation (WHO) has emphasized the need for an improvement in nutrition. Indeed there is increasing public health awareness with respect to nutrition. Today, living healthily is associated with less consumption of animal fats and red (processed) meat, moderate or no consumption of alcohol coupled with increased physical activity, and frequent intake of fruits, vegetables and whole grains (Bingham 1999; Johnson 2004). This idealogy partly stems from scientific epidemiological evidence supportive of an inverse correlation between the consumption of fruits and vegetables and the development cancer. Besides fibre and essential micro-nutrients like ascobate, folate, and tocopherols, the anti-carcinogenic properties of fruits and vegetables are generally thought to be rooted in the bioactivity of secondary plant components like flavonoids (Johnson 2004; Rice-Evans and Miller 1996; Rice-Evans 1995). Along with the increased public health awareness, has also come a burgeoning and lucrative dietary supplement industry, which markets products based on polyphenols and other potentially healthy compounds, sometimes with questionable promises of better health and increased longevity. These claims are based on accumulating in vitro and in vivo evidence indicating that flavonoids and polyphenols in fruits and vegetables can hinder proliferation, induce apoptosis of cancerous cells (Kern et al. 2005; Kumar et al. 2007; Thangapazham et al. 2007), act as antioxidants (Justino et al. 2006; Rice-Evans 1995) and influence cell signalling pathways (Marko et al. 2004; Joseph et al. 2007; Granado-Serrano et al. 2007), all of which are potential mechanisms proposed for their anti-carcinogenic activity. However, not only is the vast variety of supplements worrisome, but also problematic, is their easy accessibilty (just a click away on the internet) and the amount that can potentially be consumed. Such supplements are usually offered in pharmaceutical form (tablets, capsules, powder, concentrates) containing concentrations well beyond what is normally comsumable from the diet. For example, quercetin's recommended intake is about 1g daily. However, estimates portend a possible daily increase of upto 1000 fold of the daily intake of quercetin (Hertog et al. 1995). Mindful of the concept of dose coined from the words of swiss scientist Paracelsus "What is it that is not poison? All things are poison and nothing is without poison. The right dose differentiates a poison and a remedy." ("Alle Dinge sind Gift und nichts ist ohn' Gift; allein die Dosis macht, dass ein Ding kein Gift ist"), it is thus conceivable that such high concentrations may not only reverse the acclaimed positive effects of flavonoids and polyphenols but also have negative effects thereby representing a health risk. The fact that direct evidence of the beneficial effects of flavonoids and polyphenols remains wanting, if not entirely lacking, coupled with the afore-mentioned marketing trend demands for a thorough examination of the possible adverse effects that may arise from increased consumption of flavonoids and polyphenols. The genesis and progression of cancer is usually accompanied by dysfunctional signalling of certain cell signalling pathways. Typical for colon carcinogenesis is the malfunctioning of the Wnt-signalling pathway, a pathway, which is crucial for the growth and development of normal colonocytes. The dysfunction of the Wnt-signalling pathway occurs in a manner that culminates in a proliferation stimulus of colonocytes, while differentiation is increasingly minimized. Hence, tumourigenesis is promoted. Interupting the proliferation stumuli by intervening in the actions of components of the Wnt-signalling pathway is one potential mechanism for the anti-carcinogenic action of flavonoids and polyphenols (Pahlke et al. 2006; Dashwood et al. 2002; Park et al. 2005). However, as previously hinted, the indulgence in the consumption of flavonoids and polyphenols based supplements could instead lead to a proliferation stimulus and provoke or promote carcinogenesis in normal cells or pre-cancerous cells respectively. The aim of this work was to
- Structure and reactivity of solvated transition metal ions and complexes (2008)
- Within this thesis a series of molecular species has been studied, with focus on hydrogen bonded species and on (solvated) transition metal complexes. Experimental techniques such as FT-ICR-MS and IRMPD were combined with ab initio calculations for the determination of structure and reactivity of the aforementioned types of systems. On the basis of high level electronic structure calculations of neutral water clusters (H2O)n with n = 17-21 a transitional size regime has been determined, where a structural stabilization between all-surface and interior configurations alternates with the addition or removal of a single water molecule. Electronic structure calculations suggested that for n = 17 and 19 the interior configuration would be energetically more stable than the all-surface one. The gas phase infrared spectrum of the singly hydrated ammonium ion, NH4+(H2O), had previously been recorded by photodissociation spectroscopy of mass selected ions and interpreted by means of ab initio calculations. The present work provides additional information on the shape of the potential energy curves of NH4+(H2O) along the N-H distance on MP2/aug-cc-pVDZ level of theory yielding an anharmonic potential shape. Calculation of potential energy curves of the O-H mode of the intramolecular hydrogen bond of various dicarboxylic acids (oxalic to adipic acid) revealed that the shapes of the potentials directly correlate to the size of the system and the resulting ring strain The shape of the potential is also influenced by the charge of the system. Calculation of anharmonic frequencies based on the VPT2 approach lead to reasonable results in all systems with narrow potentials. IRMPD spectra of complexes in the gas phase have been recorded for a series of cationic vanadium oxide complexes when reacted with acetonitrile, methanol and ethanol. The experimental spectra are compared to calculated absorption spectra. The systematic DFT study identifies potential candidates for reductive nitrile coupling in cationic transition metal acetonitrile complexes. On the basis of the calculations, the formation of metallacyclic structures in group 3 through 7 complexes can be ruled out. Solvation of the transition metal cation by five acetonitrile ligands leads to a reductive nitrile coupling reaction in three types of complexes, namely those containing either niobium, tantalum or tungsten.


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Kitchen. Saturday , July 22nd , 2017 - 23:09:17 PM
If you're going to get people sitting at your island, you'll want to create things a tiny bit taller. As the focus of the room, the island is going to have a huge effect on your space. While the easy and basic islands continue to be preferred by many, you'll get to observe pieces offering a whole lot more than that additional countertop in your cooking space. Keep reading if you want to learn what you have to know so it is possible to select the perfect kitchen island.
For a long time, a sink made from stainless steel has been the most typical type which you find in kitchens all around the nation. You also ought to locate a sink which has a very very good undercoating and is padded. Also, take some time to assess the region where you're likely to install the sink (in this way, you don't need to make a huge mistake of purchasing a too small or too major sink). If you've decided that you're certainly going to replace a sink, you will require these tools and materials. You can think about a single bowl sink which is perfect for different uses besides just kitchen tasks.
Splashbacks made from tiles or stone are usually held together using grout. Personalising splashbacks made from glass is comparatively easy when compared to other materials and this is the reason why, a great deal of manufacturers are providing bespoke splashbacks. They are available in a large choice of colours ranging from black to transparent and everything in between. On the flip side, glass splashbacks don't have any grouting and don't collect any grease or grime.
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- Latest available (Revised)
- Original (As made)
This is the original version (as it was originally made). This item of legislation is currently only available in its original format.
3. In regulation 27 (frequency of inspections) of the principal Regulations—
(a)in paragraph (1)(a), for "(2), (3), (3A) and (3B)" substitute "(2), (3), (3ZA), (3ZB), (3A) and (3B)";
(b)after paragraph (3) insert—
"(3ZA) Paragraph (1)(a) does not apply to a closed children's home.
(3ZB) Where a closed children's home ceases to be a closed children's home—
(a)before 1st October in any year, the Chief Inspector must arrange for that children's home to be inspected at least once before 31st March that year;
(b)on or after 1st October in any year, no inspection of that children's home is to be carried out that year."; and
(c)in paragraph (5)—
(i)at the end of sub-paragraph (a) omit "and"; and
(ii)at the end of sub-paragraph (b) insert—
"; and
(c)"closed children's home" means a children's home in respect of which a condition imposed under section 13(5) of the Care Standards Act 2000 is for the time being in force that the registered person(1) must inform the Chief Inspector of their intention to accommodate children at the home at least three months before any child is accommodated".
The person who is registered as the person who carries on or manages the children's home under Part II of the 2000 Act.
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By sundance The Federal Judge, Kimba Wood, who is making decisions in the case against President Trump's attorney Michael Cohen, is the same person who officiated George Soros wedding. Go figure. Today Judge Kimba Wood demanded, in open court, that attorney Michael … Continue reading → …read more
Source:: TheConservativeTreeHouse.com


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I have always like my mother in-law's homemade spaghetti sauce, but she likes hers good and meaty. So, I came up with this alternative and it's just as delicious and I don't even think she would know the difference ('cuz I've slipped some other vegan foods by her with her being none the wiser!😉). 408 more words
Tags » Vegan Main Dishes
Lemon Alfredo Squash Noodles (Vegan)
I was so excited about this recipe and was so pleased with how it turned out. Yum! I used my spiralizer on some yellow squash and topped it with a delicious vegan lemon Alfredo sauce, roasted edamame (soy beans) and fresh basil. 710 more words
Southwest Avocado Zucchini Noodles (Vegan)
Hello there! It's been a while. I knew when I started this blog that I was going to be starting school again soon and that I probably wouldn't have a lot of time to play around with recipes and blog about it, and I was right. 1,034 more words
Vegan Chili
We have finally had a few chilly days so of course it's time to make chili! I have tried many different vegan chili recipes and I've combined all the things I have liked and came up with my own concoction. 370 more words
King Ranch Chicken (Vegan)
Don't let the title fool you, there's no real chicken in this. I've had this recipe for many years, it's been one of our favorites, and I've adapted it to make it vegan. 603 more words
Feijoada. Brazilian Black Bean Stew.
This is a delicious, vegan version of a hearty black bean stew, courtesy of Brazil. Packed with rich flavours: the warm smokiness of smoked paprika, the tartness of tomatoes and the sweetness of sweet potato and mango. 329 more words
Mujadara (Vegan)
Okay so I had to take a break from Debbie's Food Smarts because there simply hasn't been time for hobbies here lately. I live in the Greater Houston Area and on Aug. 621 more words


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WDRC announces annual Peace Builder Award recipients
Filed on 13. Oct, 2016 in Business Briefs, Contents, Events, Nonprofit Notes
Each year, the Whatcom Dispute Resolution Center's Board of Directors considers the nominees and chooses the winners of the Peace Builder Awards, which celebrates groups, individuals and organizations that are dedicated to strengthening community. For the 14th annual awards, the winners are as follows: -The Lummi Nation won the Transforming Justice Award for transforming the [...]
Washington's hotels and restaurants launch new hospitality association
Filed on 11. Oct, 2016 in Business Briefs, Contents, People On The Move
Hospitality leaders from across the state have joined together to launch a new trade association, the Washington Hospitality Association. A year ago, the Washington Restaurant Association and the Washington Lodging Association started working to combine their efforts. Anthony Anton, who served as president and CEO of the restaurant association for nine years, will now head [...]
WYPS monthly social set for Oct. 27
Filed on 11. Oct, 2016 in Business Briefs, Contents, Events
The Whatcom Young Professionals are holding their social at BelleWood Acres this month. The event is on Thursday, Oct. 27 from 5:30-7:30 p.m. This month's social has a Halloween twist, in addition to the usual casual networking. There will be a costume contest at 6:30 p.m., prizes and several other surprises. Be sure to bring [...]
Shuksan Healthcare Center makes new hire
Filed on 11. Oct, 2016 in Business Briefs, Contents, People On The Move
Shuksan Healthcare Center has added occupational therapy assistant Kim Gong as the newest full-time member of its therapy team. Gong originally joined the team on a part-time basis in the spring. He graduated from Washington State University with a bachelor's degree in kinesiology. Shuksan Healthcare Center is a 52-bed rehabilitation and recovery facility in Bellingham [...]
Shuksan Healthcare Center announces two new hires
Filed on 07. Oct, 2016 in Business Briefs, Contents, People On The Move
The Shuksan Healthcare Center has added two new members to its management team. Emily Benekritis joined the center originally as a CNA in 2012and was promoted to activity director in September. Ashley Gillam joined the center as admissions coordinator. Shuksan Healthcare Center is a 52-bed rehabilitation and recovery facility in Bellingham for individuals after hospitalization. [...]
Local hypnotist wins leadership award
Filed on 07. Oct, 2016 in Business Briefs, Contents, People On The Move
Bellingham hypnotist Erika Flint won the prestigious Hypnosis One Percenter Leadership award at the National Guild of Hypnotist's annual conference. The award recognized Flint as a role model for professional hypnotist's to emulate. Flint is a certified hypnotist with the National Guild of Hypnotists, and works out of the Cascade Hypnosis Center. To contact Flint, [...]
SSK Insurance kicks off food drive
Filed on 06. Oct, 2016 in Business Briefs, Contents
SSK Insurance has kicked off its fifth annual turkey drive. The goal is to feed 200 local families this holiday season. The insurance company will match contributions of $15 for each turkey donated, up to 100 turkeys through Dec. 14. Donors will also receive recognition on the insurance company's website and Facebook page. The turkeys [...]
Cascadia International Women's Film Festival selects programming director
Filed on 06. Oct, 2016 in Business Briefs, Contents, Nonprofit Notes
Tracy Rector has been selected as programming director for the new Cascadia International Women's Film Festival, based in Bellingham. Rector is a Seattle filmmaker, and will be selecting documentaries directed by women for the festival. The festival will be on Oct. 28-30 as part of Doctober at the Pickford Film Center. This is the second [...]
BTC to celebrate manufacturing day with open house
Filed on 06. Oct, 2016 in Business Briefs, Contents, Nonprofit Notes
The public is invited to an open house as Bellingham Technical College celebrates manufacturing day on Friday, Oct. 7 from 4-7 p.m. The open house is at the college's technology development center at the Port of Bellingham, at the composite engineering program, located at 1000 F St. Refreshments will be served. The event will include [...]
Whatcom Symphony Orchestra announces new executive director
Filed on 05. Oct, 2016 in Business Briefs, Contents, Nonprofit Notes, People On The Move
The Whatcom Symphony Orchestra announced Gail Ridenour as the new executive director. Ridenour has a past playing in the orchestra. She also currently teaches music in the Bellingham School District. Ramona Abbott is currently serving as the interim executive director and will continue until Ridenour starts sometime in 2017.


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Product DescriptionPremium Choice Incense By Oakland Gardens.........Our handmade incense are soaked for a minimum of 48 hours, burns for 20-30 mins and fragrance lasts as long as 24 hours in a room
- Premium Choice Incense By Oakland Gardens
- Purchase all 6 Types with Incense Wooden Boat
- Approx 100 x Incense Sticks (142+ Grams) per Incense Type
- Excellent For Meditation and the like Arts ... Freshly Hand-made for Long-lasting scent
- Our handmade incense are soaked for a minimum of 48 hours, burns for 20-30 mins and fragrance lasts as long as 24 hours in a room
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Speed dating roseville Chatroulette100free
The idea is described as "a truly immersive galactic experience." There will be parties and events every night that the bars are open, including a "intergalactic burlesque show," trivia, dancing and DJs, and "alien speed dating." The bar will serve six custom cocktails and will have "galaxy-inspired" food fare that varies from day to day.
The website recommends reservations, which are per person, but will welcome walk-ins – for – if there's room.
(@Marin Sheriff/Twitter)Officials in Mill Valley say an out-of-control driver sent several people to the hospital on Tuesday afternoon.
According to the CHP, it started on Highway 101 when a large pickup truck crashed through the fence, crossed the road, and ricocheted off of cars waiting in line at the restaurant. Jeff Brant says there were six family members in his minivan when the truck made impact.
DOMINICK (Catholic Singles): 712-276-4029 Loners on Wheels, Singles Camping Group, Monthly Campouts, 712-233-2363. Weekly meetings Fridays 7PM, Market Place Mall, 3022 Hamilton Blvd. Emmanuel Baptist Church, 10100 Metcalf, large singles group, lots of activities. Church of the Resurrection United Methodist, 6545 W. Meets every Thursday at 7pm, call 913-897-0120 for more information.
"Brant: "This is my birthday and I am thinking I am pretty darned lucky today." When asked how fast the driver was traveling, Officer Andrew Barclay says the best estimate was freeway speed Barclay: "From what they've heard from a couple witnesses is he came off the freeway at full speed."Freedman: "Through the fence?
Social meetings, pm Fridays at Jacks House of Bowling, dining room, 218-829-2900 Ext. Meets every Tuesday at pm, 2nd floor American Legion, downtown.
Lake Area SAT--Singles All Together, Colonial Church of Edina, 6200 Colonial Way.
All lanes of eastbound Interstate Highway 80 in Emeryville just west of the Emeryville exit are now open after being closed for hours after a crash that killed a person Sunday, the California Highway Patrol said.
A Sig-alert that was called has now been cancelled.
Three bars opening this month across the United States give you a chance to "cross over to the Dark Side." The Dark Side Bar is a limited-time pop-up spot based on "Star Wars" opening in Los Angeles, New York and Washington, D. "Dark forces are taking over for a (very) limited time.


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StreetScout / SEARCH: 12029 N 112TH Drive Youngtown, AZ 85363
- 3 beds
- 1.5 baths
- $149,375 price
- 5716009 listing id
- Half Baths: 2
- Square Feet: 1,127 sqft
- Year Built: 1955
- Neighborhood: YOUNGTOWN LOTS 52-101
- Status: Active
This is a great starter home that is priced to sell. It is centrally located in Youngtown. Close to parks, shopping, transportation and city services. A/C less than one year old, Evap. cooler, newer roof, hot water heated and flooring. Master bed room has 3/4 bath with in house laundry. Large corner lot, detached single car garage with 3 car on slab parking. Shown by appointment only. NO SIGN IN YARD.
Community Information
Courtesy of: West USA Realty
Office Phone: (602) 375-3300
Copyright Arizona Regional Multiple Listing Service, Inc. All rights reserved. Information is deemed reliable but not guaranteed.
Updated: 25th April, 2018 7:56 AM.
12029 N 112TH Drive Youngtown, AZ
Streetscout Powered by Placester


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Black Hotel
Select your stay dates to check availability at Black Hotel
Black Hotel
About the Hotel
Property Location
With a stay at Black Hotel in Rome (Aurelio), you'll be close to Hydromania and St. Peter's Basilica. This 4-star hotel is within close proximity of Sistine Chapel and Vatican Museums.
Make yourself at home in one of the 67 air-conditioned rooms featuring minibars. Complimentary wireless Internet access keeps you connected, and satellite programming is available for your entertainment. Private bathrooms with showers feature designer toiletries and bidets. Conveniences include safes and desks, and housekeeping is provided daily.
Don't miss out on the many recreational opportunities, including a health club, a sauna, and a seasonal outdoor pool. This hotel also features complimentary wireless Internet access, concierge services, and babysitting/childcare. If you're planning a day at a nearby theme park, you can hop on the complimentary shuttle.
Satisfy your appetite at the hotel's restaurant, which serves breakfast and dinner, or stay in and take advantage of 24-hour room service. Quench your thirst with your favorite drink at a bar/lounge.
Business, Other Amenities
Featured amenities include a 24-hour business center, limo/town car service, and express check-in. Planning an event in Rome? This hotel has 1044 square feet (97 square meters) of space consisting of a conference center and a meeting room. For a surcharge, guests may use a roundtrip airport shuttle (available on request) and a train station pick-up service.
Hotel Facilities
- Number of floors - 3
- 24-hour business center
- Shopping on site
- Conference center
- Babysitting or childcare
- 24-hour front desk
- Express check-in
- Dry cleaning/laundry service
- Health club
- Laundry facilities
- Porter/bellhop
- Conference space size (feet) - 1044
- Free breakfast
- Free newspapers in lobby
- One meeting room
- Concierge services
- Restaurant
- Sauna
- Smoke-free property
Room Facilities
- Turndown service
- Designer toiletries
- Hypo-allergenic bedding available
- Pay movies
- Daily housekeeping
- Minibar
Hotel Policy
Know Before You Go
- All guests, including children, must be present at check-in and show their government-issued photo ID card or passport.
- Cash transactions at this property cannot exceed EUR 2999.99, due to national regulations. For further details, please contact the property using information in the booking confirmation.
- This property offers transfers from the airport and train station (surcharges may apply). Guests must contact the property with arrival details before travel, using the contact information on the booking confirmation.
- Reservations are required for massage services. Reservations can be made by contacting the hotel prior to arrival, using the contact information on the booking confirmation.
- The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
- Guests can arrange to bring pets by contacting the property directly, using the contact information on the booking confirmation.
The following fees and deposits are charged by the property at time of service, check-in, or check-out.
- Crib (infant bed) fee: EUR 20 per night
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
Mandatory Fees and Taxes
You'll be asked to pay the following charges at the property:
- A tax is imposed by the city: EUR 6 per person, per night, up to 10 nights. This tax does not apply to children under 10 years of age.
We have included all charges provided to us by the property. However, charges can vary, for example, based on length of stay or the room you book.Show all hotel policy Show less hotel policy


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It takes a particular person to turn out to be a health care provider. Most of the medical colleges in Turkey are state schools however the number of non-public faculties is on the rise. The admission to medical studies in Czech Republic is predicated on the efficiency in highschool diploma (Biology, Chemistry and Physics), English proficiency and performance in the entrance exams.
Since 1990, LSMU has been the Alma Mater of many worldwide students and 550 full-time foreign students from 42 nations (mainly Israel, Germany, Finland, Norway, Spain, Sweden, Lebanon, Poland, India, South Korea, Eire and the United Kingdom) are at the moment enrolled right here.
Graduates of the Royal Faculty of Surgeons in Ireland also receive the standard "Licenciate of the Royal Faculties of Surgeons and Physicians in Eire" (LRCP&SI), which was awarded earlier than the Royal College of Surgeons in Ireland became an Affiliate of the National University of Eire and thus was allowed grant levels, below the Medical Practitioners Act (1978).
The primary medical school in Thailand has been established again in 1890 at Siriraj Hospital , which is now turn into School of Medication Siriraj Hospital, Mahidol College At the present time, there are 22 43 …


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KitzSki TV
Current program
Current news
TIPP! KitzSki Saisonkarte 2018/19 ab 10.05. zum SUPERVORVERKAUFSPREIS!
HAHNENKAMM Special bis 1.Mai: Erwachsene EUR 35,00 | Jugendliche EUR 17,00 | Kinder EUR 10,00
Current lift status
Current slope status
Livecams in the ski resort
KitzSki TV
KitzSki TV
Current program
Current weather Hahnenkamm
Dry and sunny throughout the day with hardly any clouds.
Data is supplied from ZAMG
"Best of KitzSki"
Experience the varied ski routes and get to know the insider tips of the KitzSki Arena.
Red Bull
Location Hahnenkamm - Pengelstein - 800 m
Rustic and modern. Meat from our own farm, children's restaurant (particularly suitable for ski schools; parents can sit at the bar and keep an eye on their children or eat with them). Located in the lower region of the finishing slope.
Manager: Susanne Reisch
Owner: Dr. Klaus Reisch
7.00 a.m.–7.00 p.m.
Mid-December to the end of March
A1 Hahnenkammbahn / A2 Ganslern
Radio Swiss Pop
160Indoor seats
80Outdoor seats
Everyone is welcome during the Hahnenkamm race (no passes needed!)
Open from 6.00 a.m. to 8.00 p.m. during the week of the Hahnenkamm race.


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4 Elements of Effective Feedback
My immaturity is exposed when it comes to providing and receiving feedback. In 2018, I am committing to changing the way I do this as a leader. One of the reasons I am posting this in a public forum is to open myself up for healthy feedback whenever I provide or receive it incorrectly from this point forward. I have dwindled feedback into four different elements that might help you in the development of your team.
- The Feedback Window — The time in which the feedback is provided. Most of the time, in leadership and especially in marriage, I have discovered that when you provide the feedback is just as critical as to what the nature of the feedback is. I have lived in the reality of saying the right thing at the wrong time for a long time. The revelation to the reality of a feedback window allows for both parties to expect an interaction that they can be prepared for. Feedback that surprises, that is, feedback without warning, won't stick because of how much it stings. Recognizing and identifying your own feedback window is the first step. Audit your reactions to previous feedback sessions and set up the ideal time to receive outsider insight. This is extremely practical and something I wish I would have learned 10 years ago when starting out in full-time ministry. I would have been mature enough to recognize my emotional vulnerability and it would have brought more composure to my demeanor during those meetings. The second step is making sure you know when the recipient's window is. This way you can time your delivery to match their window. Great leaders know their own window and the window of those they lead. Auditing my ministry career, I could have saved myself losing a ton of sound technicians had I waited until the appropriate time to provide feedback on the feedback. My feedback window is from Monday after lunch to Tuesday evening. This is critically important for me to realize. Even more important for my team to realize. By Monday at noon, I have slept, ate & exercised prior to hearing how terrible my sermon was from someone who has never preached. That's why I don't do email until Monday evening.
- The Feedback Method — The way in which the feedback is delivered. We love to text in 2018. We love to hide behind tiny screens and deliver shots that neglect vocal tone and body language. This has gotten me in trouble on multiple occasions. Texting is quite possibly the worst method to deliver feedback in. It presents no context. It prohibits a genuine dialog. Now the flip side to feedback is the need for documentation that adjustments need to be made. Feedback without follow-up will result in repeated failure. There are very few methods that can replace a face to face meeting. My feedback method of preference is a face to face meeting with documentation as a follow-up.
- The Feedback Frequency — The schedule in which the feedback is communicated provides consistency. A one-time feedback meeting leaves both parties in an unknown state. There needs to be an ongoing improvement plan. Frequency allows for the level of trust to increase as the relationship develops. Feedback given frequently will become easier over time. Attend enough staff meetings with Mike Santiago and eventually you will know what the expectations are. As trust levels rise, so does the ease of the delivery of feedback and the frequency of that feedback. When you give frequent feedback you get better at delivering it based on the core principles and not emotional responses to stuff that really doesn't matter. My desire is to have feedback weekly. Because I preach every week and our church is open for a joint gathering every 6 days, this means that I need the frequency to be weekly.
- The Feedback Loop — The cycle in which the feedback is given and received. Correction is not feedback because correction does not allow for a loop to happen. When feedback is unidirectional, it's really not feedback, instead, it's actually correction. Correction is what I do when I discipline my kids, feedback is what I give and receive when I meet with my team. Correction comes from a place of authority, feedback comes from a place of authenticity. It is critical to let the door swing both ways in a setting where feedback is happening. Allow the recipient to voice not only their opinion, but to provide outsider insight to you as a team member.


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Custom built as builder's own, 4428 SF of finished space with numerous upgrades and amenities not found in many homes at this price. Kitchen is well planned with custom maple cabinets, stainless appl, granite tops and an ample pantry. The fm room features a gas starting fireplace flanked by custom built-ins. Enjoy the outdoors from 16'x16' screened porch with knotty pine ceiling and built-in natural gas line for grill or patio heater. Relax in the secluded outdoor hot tub with access to 1st floor full bath. The master has lighted tray ceiling, oversized walk in closet, en suite bath with tiled shower, jacuzzi and dual vanities. Basement boasts a FULL kitchen, TV area with custom built-ins, 5th BR and 4th bath. Surround speakers on all 3 levels, beautiful 3 stage crown moulding, Anderson windows and doors, hard wired security sys and dual zoned HVAC. Quiet 1 block long street tucked away in Ironwood West neighborhood with paved trails, park w/ playground, easy interstate access.
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2104 Wiggins Street, Champaign, IL, 61822 is a Single Family Home for sale at $438,000 with 3,016 sqft and a lot size of 83 X 132. 2104 Wiggins Street has 5 bedrooms and 4.0 baths. The property's zip code is 61822 which is in Champaign, IL
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