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MOVED – Visit Akron's new blog
Our blog has moved!
Update your bookmarks and visit us at our new location: https://www.akronbiotech.com/about-us/news/
– The Akron Team
Akron Biotech at Cell and Gene Therapy World – All the Events
Cell and Gene Therapy World, organized by Phacilitate, is taking place this coming week. After multiple years in Washington, DC, the conference has moved to Miami, Florida, where from January 17 – 20, 2017 delegates will be able to interact with over 350 companies discussing the latest advances in the commercialization of cell and gene therapies.
The entire agenda can be accessed here.
Akron will attend and participate at Cell and Gene Therapy World through a number of panels, talks and our in-person booth.
Please stop by booth #114 to meet us and learn about our latest discoveries, products and technologies. We will be there for the entire duration of the conference, and welcome anyone to interact and see the innovations we will be presenting.
Panels and Talks
Akron will participate in a number of panels and talks.
Dr. Claudia Zylberberg, Akron's CEO, will participate in the panel Examining the cutting edge in game-changing cryoformulation, cryopreservation, thawing and storage technologies and techniques in action. The panel takes place on January 18, 2017 at 12:45 – 1:30.
Dr. Sandro Matosevic, Senior Director of Research and Development, will present during the session titled Clinical vs. commercial logistics: preparing for and navigating the transition from clinical to commercial scale. The session is scheduled to take place between 4:45 – 6:00 PM on Wednesday, January 18, 2017. The session will include presentations, a panel discussion and an audience Q&A.
Meet Us
Alongside public appearances, Akron will be available to meet, on a one-on-one basis, any party interested in discussing potential collaborations, partnerships or any of our products or technologies. Please contact us directly.
We hope to see you at Cell & Gene Therapy World!
Scaffolds Promote the Development and Growth of Organoids
Organoids – miniature organs produced via stem cells which show three-dimensional, tissue-like arrangement – enable, through physiologically-relevant environments, the study of various pathologies which these structures are assembled for. Typically assembled devoid of scaffolds, organoids have been used for both drug discovery and as three-dimensional tissue engineered constructs. As tissue engineered assemblies, organoids have originally been formed on the basis of cultured stem cells, such as induced pluripotent stem cells, which rearrange, through spatially-restricted lineage committment, into layered structures.
In the last few years, studies have highlighted that organoids can be enhanced with the introduction of substrates to which cells adhere.
In 2016, a manuscript by Dr. Timothy O'Brien from the Stem Cell Institute at the University of Minnesota described the generation of cerebral organoids from human pluripotent stem cells with the support of a chemically defined hydrogel. They managed to achieve protein expression representative of forebrain, midbrain, and hindbrain development. The manuscript was published in Stem Cells Translational Medicine.
This was demonstrated again last week, when a new study appeared which described the development of scaffold-support human lung organoids. Authored by lab of Dr. Jason Spence at the University of Michigan Medical School, the manuscript, titled A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids, presented the development of microporous poly(lactide-co-glycolide) (PLG) scaffolds as substrated onto which human pluripotent stem cell-based organoids developed into maturate of lung epithelial tissue.
Upon transplanting scaffold-grown organoid tissue, airway-like epithelial tissue was observed. This was attributed to the enhanced support provided by the polymer-based support scaffolds.
The authors argued that this study was the first demonstration of the development of hPSC-derived human lung organoids which showed robust engraftment in vivo and differentiation into an organized pseudostratified epithelium.
Organized cartilage was observed following Safranin0 stanining within the scaffold-human lung organoids following transplantation (Figure above), alongside cartilage marker SOX9, and the human mitochondrial marker huMITO. The scaffold-human lung organoid also displayed abundant vasculature within the tissue.
This manuscript, alongside previous other studies, forms a growing body of work which suggests that providing a physical environment to stem cell-based organoids, is critical in ensuring development and organization of mature tissue-like structure and function. Further developments may shed more light into the relationship between scaffold physicochemical properties and organoid-based human tissue establishment to develop more sophisticated system for organ regeneration.
Creating cellular function: Microparticles that act as heart stem cells developed
If the development of genetic editing approaches to induce functional changes to cell behavior to enhance their efficacy has led to remarkable advances in gene-engineered cell therapy, the development, on the other hand, of synthetic systems for tissue engineered and regenerative medicine-based therapies has made inroads as a robust, fully-controllable bottom-up approach to cell and gene therapy. Synthethic approaches have often offered complementary tools – such as three-dimensional scaffolds – upon which to build in vivo-like biological function. an example of this are tissue engineered-scaffolds and three-dimensional substrates.
Now, microengineered structures have been developed which cross over to fully replace cellular function, rather than enhance it.
Case in point: A new study described the development of microengineered particles with cardiac cell-like function, as a type of "synthetic stem cell."
The work was described in a manuscript published last week in Nature Communications, titled Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome by the lab of Dr. Ken Che, associate professor of molecular biomedical sciences at North Carolina State University.
Called synthetic cell-mimicking microparticles, they are made up of poly (lactic-co-glycolic acid) (PLGA) to which cardiac cell-extracted growth factors are added. This creates, effectively, a biodegradable, synthetic shell which contains beneficial growth factors that impart biological function. Such biological function was tested both in vitro and in vivo, in a mouse model with myocardial infarction. In both cases, and particularly in vivo, the microparticles exhibited cardiac cell-like function to support cardiac tissue growth.
While biological function is successfully displayed by these structures, they do not exhibit other cellular-like activity, such as division.
Further work is expected to answer more questions about the long-term potential of these structures as therapeutic vehicles, which will bring such work closer to answering questions about its potential clinical benefit.
2016 at Akron Biotech: A year in review
Not much time is left before we close 2016 and enter the new year. As we wrap up the final few weeks of this year, we want to take the time-as we do every year-to reflect on the year that is ending.
2016 has been, for many reasons, a year of growth, excitement and surprises — globally for the cell and gene therapy field, it will be remembered for numerous breakthroughs both scientifically as well as clinically, alongside a reinvigorated federal interest in regenerative medicine and immunotherapy.
At Akron, 2016 brought all of that, alongside innovation – in discovery, manufacturing and our involvement in national and international consortia advancing the therapeutic possibilities of regenerative medicine.
Here, we want to reflect on some of Akron's highlight from this past year:
- In the first quarter, Akron announced acceptance of a Drug Master File for Interleukin-2 by the FDA, and invites all parties interested in referencing it in their regulatory submissions to submit a request.
- At the beginning of the year, Sen. Tommy Baldwin presented The Advancing Standards in Regenerative Medicine Act, which calls for the establishment of a Standards Coordinating Body in Regenerative Medicine and Advanced Therapies. Akron is part of the task force behind this SBC, efforts regarding which are still ongoing.
- Our industry-leading product portfolio expanded by the introduction of innovative new products: we reformulated recombinant Eryothropoietin which now has enhanced stability and activity, and launched a 5% HSA solution.
- Our research efforts resulted in the publication of a number of manuscripts. A highlight is a review on liposome systems for drug delivery, Pharmaceutical Liposomal Drug Delivery: A Review of nEW Delivery Systems and a look at the regulatory landscape, which was published in Drug Delivery.
- Akron was awarded an SBIR Phase II grant by the Department of Defense for our leading innovations in the space of DMSO-free cryopreservation.
- Akron has always maintained leading presence at International Conferences and symposia. 2016 was no different: Akron was featured at ISCT, ISSCR, TERMIS, CAR-TCR to name a few.
As 2016 draws to a close, we look forward to 2017 and wish everyone happy holidays.
Our blog will resume in two weeks, on January 1st – we hope to see you usher in the new year with us.
Newly discovered 'anti-CRISPR proteins' can prevent CRISPR mistakes, new study says
CRISPR/CAS9 has emerged as a flexible and effective approach for genome editing with a promise for the correction of disease-causing mutations. However, most studies have so far demonstrated CRISPR as an on/off system, with little temporal control of its activity or function. Now, new research from the University of Toronto described the discover of a number of proteins that allow to precisely do this: control the activity of CRISPR specifically and conditionally, and at defined time points.
Published in Cell, the study is titled "Naturally Occurring Off-Switches for CRISPR-Cas9" from the lab of Dr. Alan Davidson.
The authors identified naturally occurring protein inhibitors of a CRISPR-Cas9 system. A bioinformatics-based approach allowed the authors to discover three proteins that inhibit N. meningitidis type II-C CRISPR-Cas system, by interacting with NmeCas9 to function as off-switches for NmeCas9 genome editing activity.
They further showed that members of all three anti-CRISPR families bind directly to the NmeCas9/sgRNA complex and inhibit in vitro DNA cleavage. Interestingly, they displayed unrelated sequences, leading the authors to postulate that they operate under different mechanisms as well.
Evolutionarily, Cas9-associating anti-CRISPRs were postulated to prevent the acquisition of new spacers (such as viral DNA) in response to external invasions, with CRISPR having a profound effect on horizontal gene transfer. This implication has profound effects on therapeutics being developed based on CRISPR/CAS9 technology.
Therapeutically, these proteins can prevent off-target effects and are thus exciting potential therapeutic targets.
The entire study can be read here.
FDA: "Stem cell-cased cures must be supported by sound science"
In September, the Food and Drug Administration held a public hearing on the NIH campus, wherein stakeholders – researchers, the general public and investors – were called upon to voice their opinions on the current status of stem cell-based therapies in the country.
Last week, the FDA followed this up with an opinion statement, via a paper in the New England Journal of Medicine, highlighting the FDA's position of these therapies.
In the paper, FDA commissioner Robert Califf, alongside the Center for Biologics Evaluation and Research (CBER) Director Peter Marks and CBER Deputy Director Celia Witten urged caution. In doing so, the FDA warned against "unproven" treatments as well as those with "unsufficient data."
The FDA claimed,
"To ensure that this emerging field fulfills its promise to patients, we must first understand its risks and benefits and develop therapeutic approaches based on sound science"
before adding,
"Often, these cells (whether derived from autologous or allogeneic sources) are being used in practice on the basis of minimal clinical evidence of safety or efficacy, sometimes with the claim that they constitute revolutionary treatments for various conditions."
They go as far as calling the lack of data "worrisome," by adding:
"Published data derived primarily from small, uncontrolled trials plus a few well-controlled, randomized trials have not reliably demonstrated the effectiveness of stem-cell treatments even in some of the most systematically studied conditions, such as heart failure and graft-versus-host disease"
The FDA calls both autologous and allogeneic treatments concerning, albeit for different reasons.
These claims will come as a disappointment to proponents of stem cell-based therapies, particularly patients who, absence other options, were hopeful that these cures would provide the benefit other medications were not able to.
The entire paper, titled "Clarifying stem-cell therapy's benefits and risks," can be read here.


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All I ever wanted was boys. I got girls instead. I honestly wouldn't want it any other way. I wonder what it would be like to have a boy but even if I was to have another girl one day I would be tickled.
Daughter #1 came when I was just 21. She's 8 now. We knew before we left the hospital that she was a drama queen. She's held true to that to this day! She's so emotional. Life is either grand or just awful. She's got a strong conscience and is easy to discipline. She's got a very tender and compassionate heart and loves to be around people. She's very social. She went to public school until 2nd grade.
Daughter #3 came when I was 28. She had her 1st birthday last October. Like #1, she's social. She loves to be the center of attention and make everyone laugh. She's such a ham! She can be a bit dramatic (and loud!) and oh-so-sweet. I would tag her as a sanguine for sure. Oh, and she LOVES to eat. She can't stand for us to school. I guess she knows the attention is not on her. I've learned to pull a chair up to the bar and let her stand in it so she can be a part of the school day too. Or give her lots of snacks to keep her quiet!
I truly look forward to the next years of homeschool.
And just for the heck of it, here's the women who started it all. This my mother and me.

subset: commoncrawl


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Red potatoes in iron skillet on grill.
- Quartered red potatoes (One per person)
- Quartered Vidal onion
- Dash of sea salt
- Cracked black pepper
- 2 tablespoons of Olive Oil
- Fresh herbs ( thyme, rosemary or your preference)
Toss all the ingredients in an iron skillet. Make sure all the potatoes are coated with the olive oil. Place on low flame on grill. Stir occasionally so the bottoms don't burn to the pan. Potatoes are done when they are soft and have a caramelized look.We also have been picking our own fruit at the local farms. He helped me pick 35 pounds of strawberries, 4 pounds of raspberries, and so far we have only picked 5 pounds of blueberries. The first day we went out he stated to me that "This is fun. I thought it would be boring" .
We gave Shorty his own section in the garden. While right now he's not into weeding it the way I would like, he is learning how to grow his own food. I spent my life watching my grandparents plant their own food; they canned, froze and stored it. My mother and I had a huge garden that we maintained.
I sent my mother home the other night with some of my homemade bread and and freshly canned jam. She called me that night and told me she thought I should put it in the fair this fall. She loved it. She asked where I learned to cook and I told her it was from her. Her answer back was, you never wanted to help. I told her that I liked to watch and now I love to cook . So all you moms out their that think your children aren't paying attention to you, they are. And in their own sweet time they will do it .
My hope for my son is that by watching how we gather and make are own food, watch our carbon foot print by recycling, reusing, and reducing that he will continue it in his own life and someday pass it on to his family.
Words of my grandparents ring true today more then it ever did when I was growing up. They grew up in the depression and knew how to save and live on less. I think they would be very proud to see how I have passed that on to my family. My 83 year old grandmother gets a kick out of the fact that I went and bought a cloths line just like hers, hers has been up for more then 30 years. My mother still goes over to her house to hang out her sheets.
I did have to use the dryer today because laundry was getting backed up and the weather hasn't been that great. Does anyone else feel the guilt when you go back to the easier way of doing things. It happens I know.
Well enough ramblings for now.
Stay tuned for more recipes, ideas for the family and other fun stuff.


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Kenworthy's Body
You all know ESPN The Magazine, right? Well, you probably don't, but you probably heard of their Body Issue – the one with all the nude athletes. There was lots of chatter about the sizzling hot pics of Patriots wide receiver Julian Edelman. But our own Gus Kenworthy is also in the mag. He took a series of nudes over the course of six hours on a ski slope. One might expect major shrinkage, but that's not the case – as you'll see on BillyMasters.com.


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So today I am off to the Philippines on a work trip...
I will be there three weeks taking part in 2 project evaluations and a workshop. It should be a good trip, but it leaves Brett with all the packing...
I get back from my trip 6am 12 Aug and we are moving that weekend so everything will be packed when I get back.
I probably won't be able to keep you updated while I am travelling, but if I can I will.
Love to all
2011: A Year In Music [Part 4 of 4]
6 years ago


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Poverty rises in Colorado while the number of uninsured remains stagnant, according to new Census data
|Source: http://chpre.org/?p=3467
More than 166,000 Coloradans have fallen into poverty in the past five years, according to Census data released Wednesday. But two key programs serving low-income Coloradans have succeeded by providing health care to more Coloradans and preventing the rate of uninsured from rising.
The poverty rate has ballooned from a 9.8 percent average in 2006 and 2007 to an average of 12.7 percent in the two-year period covering 2010 and 2011. During that same time frame, the number of children receiving health care through Medicaid and Children's Health Inusrance Program (CHIP) increased by 126,829.
Still, the Census numbers show that overall the number of uninsured Coloradans remains relatively unchanged and that more work needs to be done to ensure that all Coloradans have access to affordable, quality health care.
"This data makes clear the important role government programs like Medicaid and CHIP are playing in Colorado as they provide a critical safety net for low-income and uninsured Coloradans" said Elisabeth Arenales, health program director at the Colorado Center on Law and Policy. "Fully implementing health care reform provides an opportunity to further reduce the number of uninsured."
The data released by the Census Bureau on Wednesday, the Current Population Survey, sheds light on three key indicators of the lives of low-income Coloradans -- health insurance coverage, poverty rates and income. The data represent two-year rolling averages, which means that in the information below 2010-2011 represents the average for those two calendar years. The federal poverty level in 2011 defined poverty for a family of three as a gross yearly income of $18,530.
Health Insurance
The share of Coloradans without health insurance remained statistically unchanged from data released last year, according to preliminary state Census Bureau figures released today. Roughly 16 percent, or 710,000 Coloradans, did not have health insurance coverage in 2010-2011.
In contrast, national data show a decrease in the number of Americans without health insurance coverage for the first time in four years, largely the result of the Affordable Care Act provision that allows young adults to stay on their parents' private health insurance plans. For the first time in 10 years, the number of Americans with private coverage remained stable.
|Source: http://www.cbpp.org/cms/index.cfm?fa=view&id=3830
Other public policies are the primary reason that uninsurance rates have held steady in Colorado. Government investment in health care through Medicaid and the Children's Health Insurance Program (CHIP) has helped cushion the loss in employer coverage during the recession, particularly for children. Medicaid covered 13.1 percent of Coloradans under age 65 in 2010-2011, an increase from 8.5 percent in 2006-2007, while employer-based coverage for the same time period declined. In Colorado, public coverage of children has risen dramatically since 2006-2007 by nearly 10 percent. According to Census, public health programs were covering 126,829 more Colorado kids in 2010-2011 than in 2006-2007.
The positive impact of the Affordable Care Act's young adult provision and the success of Medicaid and CHIP in providing coverage to children illustrate the critical importance of implementing the rest of the health care reform law.
"We have an opportunity to continue to shrink the number of Coloradans without health insurance by expanding Medicaid, successfully launching the Colorado Health Benefit Exchange and fully implementing the provisions of the Affordable Care Act," Arenales said.
The data also showed an increase in the percent of Coloradans living in poverty since the start of the recession. In 2006-2007, 9.8 percent of Coloradans were living below the official poverty line, compared to 12.7 percent in 2010-2011. Preliminary figures for 2010-2011 find that roughly 638,000 Coloradans lived at or below the federal poverty level. That represents an increase of 166,870 Coloradans living in poverty.
"The new data show that many Coloradans are struggling to get by, and we need to step up our efforts to help. Lawmakers should not make it harder for people to make ends meet by cutting vital supports to lower-income families. We need to promote and fully fund innovative policies and practices that will not only help struggling Coloradans but also boost our economy," said Tracey Stewart, economic security program director of the Colorado Center on Law and Policy.
The Current Population Survey data also showed income for most Coloradans has stagnated. Adjusted for inflation, median household income in Colorado in 2006-2007 was $64,226 and in 2010-2011 it was $60,381, a statistically insignificant decrease.
These state figures from the Census Bureau's Current Population Survey for income, poverty and health insurance in Colorado are preliminary. On September 20th, the Census Bureau will release more definitive 2011 data as part of the American Community Survey, which is a more in-depth review of poverty and income in the states.
Look for a more detailed analysis of poverty and income in Colorado from the Colorado Center on Law and Policy on September 20th.


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MEET THE WORLD MONEY POWER http://www.silver-investor.com/charlessavoie/cs_dec04.pdf << Copyright December 2004 Charles Savoie
On November 24, 1980, the Associated Press quoted Leonard Bernstein, a globally prominent musical conductor, as saying in reference to the Kennedy assassination, "We don't dare confront the implications. I think we're all agreed there was a conspiracy and we don't want to know. It involves such a powerful high force in what we call the high places, if we do know, everything might fall apart."
This is when I start to deliver what I've been hinting at for months as I have referred to the World Money Power or the Society. I say start, because a series will be necessary to convey the complete picture. In order for a few people to exercise the colossal power they do, secrecy is crucial. That's why so few outside the Society ever heard of it, or if they saw references to it, the meaning would not register. There is indeed a powerful high force in the high places! You must know about them because their existence governs your future to a disturbing extent. They are the source of fiat money; the powers behind central banks; international financiers; warmongers; globalists; cartel monopolists; and the force suppressing precious metals. JFK, whose father was a member, strayed from the plan! As Zad Rust commented in "Teddy Bare, The Last of the Kennedy Clan" (1971)— "The Warren Commission had no other mission than to conceal the truth, and it was relentlessly helped in this mission by many official agencies and by some powerful organized Force of universal scope and character.
This Force of Darkness has already brought the world very near to the point of no return on the road to total annihilation of the liberties of man and the independence of nations, and to the enthronement of the Antichrist."
This is an organization with two branches, the London branch founded in 1902, the New York branch in 1903. As rule #1 of their bylaws states, "The name of the society shall be The Pilgrims." This is what they call themselves---The Pilgrims. They may also be referred to as The Pilgrims Society; Pilgrim Society; Pilgrims of America; Pilgrims U.S.; Pilgrims of United States; Pilgrims of Great Britain; Pilgrims (London); Pilgrims (New York) or other slight variants such as Pilgrims (NYC). The name doesn't exactly sound menacing, does it? Probably less so than Skull & Bones Society (Yale University), which has had some furor raised over it in recent years.
The two organizations are interrelated, with The Pilgrims in much the dominant position, as it is with other groups with which it is interlocked. Francis F. Randolph of The Pilgrims, Wall Street financier born in 1889, was treasurer of the Russell Trust Association for many years, the corporate name of Skull & Bones, named after the Russell that founded Bones in 1832. The Yale "secret five" (including Wolf's Head Society; Book and Snake Society; Berzelius Society; Scroll & Key Society) were founded as British fronts for sons of wealthy Americans who were in league with the British Empire and its World Money Power. Russell & Company was granted opium-trading concessions in China, by the British East India Company. The BEIC didn't have to give any territory away---it did so in exchange for buying influence in America. Yale University itself is named after Elihu Yale of the British East India Company, who ran an opium-trading fort in India! You see, the British Royalty and their allied bankers NEVER give up trying to control Planet Earth!
While Alexandra Robbins made a stink about Skull & Bones with her recent book, she neglected to point out that Paul Mellon of Scroll & Key, by himself, was probably wealthier than half the Bones members combined. And while Mellon listed his Scroll & Key membership in Who's Who, he remained silent about his Pilgrim Society membership to the end. His name appeared in a 1969 list, the only known year a list was leaked to the outside world. I reviewed the list at length and concluded its authenticity from other facts available. Skull & Bones is not equal to The Pilgrims for several reasons. The most obvious reason is, reins of power are not turned over to 19 year old boys. When they get to Yale, they are inducted immediately. There is a 10-year waiting list for joining The Pilgrims --- after the person is selected (by invitation only). A death has to occur, or by a measure within the organization, decision to increase its numbers is reached. According to current figures (700), there is about a one in 410,000 chance of any American being a member. It is probably rare for a man to become a member before age 40. Also, what about the powerful people of the country who didn't attend Yale at all? Do we just paint them out of the picture because it doesn't fit into some thesis by Alexandra Robbins or Antony Sutton? Sutton, by the way, spent time at the Hoover Institution on War, Revolution and Peace at Stanford University --- of which Pilgrim Society members are trustees. Esquire magazine, September 1977 ran an article on Skull & Bones, starting on page 84. WHY haven't they had one about The Pilgrims? There are many indications that David Rockefeller, at age 89, remains the most powerful man in the country, and he came from Harvard. Ms. Robbins claimed Skull & Bones "controls the Rockefeller fortune," but gave no documentation. Societies such as Bones are indeed important but must not be equated to "the senior, Anglo-American Society," which is The Pilgrims. Not only is The Pilgrim Society exponentially the most powerful organization the world has ever known; it is relatively speaking, the most secretive; and certainly the most dangerous! The sheer network of thousands of interlocking connections is enough to overwhelm one person trying to research them. Referring to the power of the organization, in a speech at the House of Commons on August 20, 1941, Winston Churchill (a member) said, "No one could stop it. Let it roll on in full flood, inexorable, irresistible." I believe the reason why the name Pilgrims was chosen is an open secret, like their very existence. The original Pilgrims, who came over on the Mayflower centuries earlier, left the old world to found a New World where they believed they could live life their chosen way. These other Pilgrims, whose Royal roots trace back at least to early medieval times in Britain and Europe, are leaving the present world system and gravitating towards a New World---a New World Order. I have compiled enough information on these men to write millions of words length. That won't be possible here. I intend to give a summary as best I can. If anyone wishes to employ the term "conspiracy," I have no quarrel with that. This is precisely what we are examining. To believe otherwise is the summit of childish naiveté. Use the word intrigue instead if you assimilate it easier. Other applicable terms such as "Illuminati," dating to an Austrian professor on May 1, 1776---Mayday--- are heard. They are elitists who know how the world should be ordered, the rest of us are clueless. And they will do anything to achieve that order, even if it calls for the extermination of half the world's population---which appears to be part of the plan.
As to which of its members are most powerful, is subject to conjecture, and no absolute conclusion can be reached---that's all known only on the inside. What is obvious is that the British Royal family was involved with the founding of the organization, and remains involved to this moment. Also obvious is that a front man for Lord Rothschild, diamond cartelist Cecil Rhodes, provided the framework or concept for the Society in the wills he left. Americans involved in the founding included Joseph Wheeler, an ex-Confederate general (the British built a lot of war vessels for the South), and financiers and empire builders like John D. Rockefeller; Andrew Carnegie; the Vanderbilts, Mellons and Du Ponts. This plan started with the British, to preserve and increase their Empire. They realized that they needed powerful allies in their drive to control the world. The chosen allies became the North American "Robber Barons," empire builders including the Astors; Vanderbilts; Rockefellers; Harrimans; Du Ponts; Mellons; Whitneys; Harknesses and others. We can assume that however they were approached and drawn into the plan, the offer went along the lines of "you've built an empire, join us if you want to share in a World Empire!" And like a corporation with shares, the world is to be divided up according to "shareholdings" within The Pilgrims organization. I reluctantly call your attention to Revelation 13:16-18 which speaks of everyone being given a number, without which we cannot buy nor sell. If it happens it will originate from within this Society. You don't seriously believe that one man alone could rise to world prominence, without the concerted efforts of hundreds of powerful men across a span of many years, do you? It may be recalled that Rothschild emerged as the richest man in Britain at the close of the Napoleonic Wars when the Duke of Wellington won at Waterloo, Belgium in 1815. Assuming that he did become the wealthiest due to his buying shares on the exchange at collapsed prices in the panic — word was spread falsely that Napoleon won —, do not lose sight of the fact that the Royal Family still controlled the military forces of Great Britain, and if they took too strong a dislike to you, your head could come off. Also, the Royals of Britain and Europe have been at the wealth accumulation game for centuries longer than names like Rothschild and Warburg. The Bank of England came into existence decades before the Rothschilds became powers. Additionally, the British Empire controlled immense territories, from whence fantastic wealth was siphoned back to England and Europe, notably from China and India. Major Canadian banks of today, including Royal Bank of Canada; Canadian Imperial Bank of Commerce; and Toronto Dominion Bank, all contain words that point to ownership by Royal interests, then there's the Royal Bank of Scotland, of which the huge (70,000 + employees) National Westminster Bank is a subsidiary. That it shares its name with the Duke of Westminster is no accident---the current Duke, Gerald Cavendish Grosvenor, one of the Royals, owns over 300 acres of the choicest property in downtown London, plus immense land holdings in Canada, Australia, Hawaii and elsewhere. He is a leading member of The Pilgrims of Great Britain —
http://www.silverbearcafe.com/private/01.11/silverstealers-2.html <<
Why does the Obama Regime have to be the most secretive of any presidency in American history?
Could it all boil down to something as simple as Barack Obama being gay, continuing to use and abuse drugs, and not being anywhere near the magical black man that the corrupt media desperately wants him to be?
Is THAT what all the enigma, subterfuge, and Alinsky Goon Squad assaults are all really about?
Is Barack Obama our first down-low, closeted gay President and is Michelle Antoinette Obama our first fully-complicit "beard" of a First Lady?
As the agenda-driven media is always so quick to say when a conservative is accused of anything: you be the judge.
http://hillbuzz.org/is-barack-obama-gay <<
[sidebar: Critical mass has been reached at a certain level.
February 3, has come and gone again and the numbers keep on. Years growing memories' absenteeism. Painful memories alone and lonely and more painful when memories leave all alone the space that was filled with a reality, seemingly for good.
The PILGRIMS seek immortality. They've got that now and the memories for the unconscious, subconscious, conscious, superconscious and ?? enlightenment. Do we share the 'vision' ?!
An awakening from the sleep induced coma isn't but, mounting numbness tingling of a spirit screaming for the nightmare to stop. We have APARTHEID in America and ITS' really, really not exactly a sane society.
Every American needs to STOP what the doing is, and take a trip to every part of America. Meet the people that are called 'Americans'.
The RIGHT isn't and neither is the LEFT and then all the other NEITHER LEFT NOR RIGHT, aren't either, and then what about the don't really knows?
Jews got their own NEWS and that's the New York Times and but, of course, the Wall Street Journal too, whatever money smell in the morning-noon-night to carry on the day about in word armies.
And our brains suck up the insane, whatever network of the CONTROLLED "Propaganda" that has been shaping the shadow of unseen consumer choices. Trudge trudge zing-zing we wing along IT controlling our very verve in every vibe.
How can we be GUILTY? Of what for the sake of being born!
Oh my the list of sins are sold as though neon.
Lingering around here in Agenda 21, wondering about the choices of how to be around for the slow boil of a frog, some say.
Surround sound the death toll rings a not so distant bell. Hell is already known by the lay of land here, there, everywhere GREEN alright, the burying us all at Wounded Knee. At least the dignity of dying can be in a warrior's Spiritual 'Ghost' Dance.
Be a 'man' or whatever the bent is, take the poisons with the spirit of one that understands.
Allow the certain humans who have no longer the luxury of secrecy PILGRIMS ~~ to be seen for what IT is really, transparent fully in the NSA's own NOC [network of control] pilgrims toxic noxious shock and awe, wars without end now only inside their own brain chemistry.
The only 'escape' from the so called FREE WORLD is to get free in our mind about how thinking is a critical art form. CHINA-RUSSIA-IRAN and, BRICS, and there are more countries according to Karen Hudes www.kahudes.net that have turned the ignorance in this light 'on'.
Barry Sotero and his Plantation Dance of low down, we gotta tear IT down.
What is the first Jewish Black POTUS#44 named in the real truth of our completely almost 100% artificial world? Who is the BEARD "Michelle?", in any genuine known 'real truth'? Those 'daughters' have NEVER BEEN in a photo as infants or where are the Christmas pics for the whole world of GLUE I mean 'BLUE' to make shrines for. Then, the BLOB and other worshiping SLOBS as well, the multitude of star gazers galore want to carry pics for slobbering on.
BUSH FAMILY? How do the "Christian Right" or whatever the "Conservative Americans" ?? Tea Party, Koch Brothers, Ron Paul devotees, Gold Bugs, Silver Experts, Metal Collectors, and of course in all this collective there are multitude of spin-off factions ... what is REALLY Be LIE ved about the Bush Family and ITS' complete corruption?! Contaminated to the absolute tap core.
Americans have not been well educated nor well informed for no less than one hundred (100) years.
Guns, weapons, drugs, 'religion', whatever 'product' can be manufactured-sold-consumed. America the land where whatever is sold in the information stream of hypnotic mind control is FREE.
Mexicans that are never to be called Hispanic or any Latino Label. Asians and the spins of different 'cultures' are countless. Religious factions in so many the numbers of 'faith organizations', the spins are staggering out of control.
PILGRIMS that have been moved from home and forced to live in FREE AMERICA.
Humans are a commodity and the commandeered (sequestered & austerity) incestuous paedophilia
'western' PILGRIMS have to share the 'earth' NOW, with the EAST and this can be certainly 'an interesting time'.]
.. to be continued ...


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Last year I took a class an introductory course on Microsoft's Photo Story 3 for Windows and brainstormed various ways that this new technology could be used in our classrooms. The first project that we designed for our students was in Mr. Stein's Participation in Government classes (Grade 12). The topic of the assignment was Humanitarian Organizations. Students were assigned with the creation of a Public Service Announcement (PSA) promoting the missions and methods for six prominent non-profit organizations. We defined a PSA as a non-commercial advertisement broadcast for the public good. The main idea of our PSAs were to modify public attitudes by raising awareness about specific issues. Once each student was assigned to a group and given an organization to profile this project had 6 steps outlined below. Once each phase was completed students were required to report their progress to the "Project Managers" (teacher/librarian).
This project was a great fit for Photo Story. The classroom teacher and I worked collaboratively to create a meaningful assignment that worked with this technology. We didn't take a square peg and try to fit it into a round hole. I think it is important for teachers and school librarians to remember that Photo Story is NOT PowerPoint. They should not rework all of their previous PowerPoint projects and convert them to Photo Story projects simply because this is the latest technology fad. The technology should complement and be appropriate to the assignment, not the other way around. Photo Story should be used for digital storytelling. Please see image above (created using Wordle) for inspiring Photo Story classroom applications. PowerPoint should be used for creating dynamic and high-impact presentations. These tools can be used to teach our students different and equally important 21st century skills. If used correctly, Photo Story can be used as an instrument to enable our students to improve their writing skills. The purpose of using Photo Story is to tell a story, so by using this technology our students gain practice scripting a narrative. PowerPoint should be used as a visual aid when presenting information orally to an audience. Since studies show that the audience will only remember three messages, our students need to decide what information is important to communicate. The most important skill when using PowerPoint is to practice/rehearse the presentation, as most students fear public speaking. Photo Story and PowerPoint are both technologies that can enhance project-based learning, but they serve different purposes and should be used fittingly.
These are the PSAs created by Mr. Stein's classes. Below are simplified instructions of the project, along with the organizations our students profiled.
Step 1: Research: Use the materials provided in the library and on the Internet to learn about the organization.
Step 2: Brainstorm: Generate strategies for explaining your organization in a way that will get others to take action.
Step 3: Write Treatment: A Treatment is a written description of what you intend to show and accomplish in your finished piece. Treatments must be approved by the teacher.
Step 4: Write a Script: Even if you do not intend to use any dialogue at all you'll need a script describing the images and the associated sounds the viewer will see and hear.
Step 5: Produce Podcast: Using still images, narration and music in Photo Story create a podcast/netcast.
Step 6: Present: Finally students will present their video and post it to the class blog explaining why we should support their organization.
Sunday, December 28, 2008
Is Photo Story the New PowerPoint?
Labels: Netcast, Photo Story, Podcast, PowerPoint
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- January 1, 2009 at 8:38 PM
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Cytocentric Visionaries: Hal Broxmeyer, Indiana University
How the Shock of Room Air Oxygen Reduces Stem Cell Yields
Alicia Henn, PhD MBA, Chief Scientific Officer, BioSpherix
Dr. Hal Broxmeyer is a Distinguished Professor, Professor of Microbiology/Immunology and Co-Leader of the Program on Hematopoiesis, Malignant Hematology, and Immunology at Indiana University Simon Cancer Center. He has chalked up well over 1,000 scientific publications and his work has been seminal to the field of hematopoietic stem cell transplantation. His group's 2015 paper in Cell and the subsequent review article are landmark papers that demonstrate how room air oxygen exposure during cell isolation inflicts damage on freshly isolated stem cells.
Here, we talk with Dr. Broxmeyer about his work. This interview was conducted by email and edited for length.
AH: We see you as a Cytocentric Visionary because of your decades of work elucidating the biology of hematopoietic progenitor cells in physiologically relevant oxygen conditions. Why were you interested in investigating the effects of room air exposure on HPC?
HB:The bone marrow microenvironment where hematopoietic stem (HSC) and progenitor (HPC) cells mainly reside in the adult is hypoxic (~1-5% oxygen), compared to that of ambient air (~20% oxygen; normoxia). Even cord blood is lower in oxygen than ambient air.
We have been interested in the comparative effects of hypoxia and normoxia on the growth of HPCs and HSCs since the early 1980s. That's when Randy Yerden first loaned us his "oxyreducer" to do some preliminary studies on colony formation by HPCs prior to us purchasing it. We clearly showed that colony formation was much improved when the cells were grown in hypoxic compared to normoxic cultures. We also showed that the cells grown in hypoxia were more sensitive to growth regulating cytokines, which made sense since lowered oxygen is a more physiological environment for these cells. Yet, all studies performed prior to our recent paper [1], including our own, processed the cells in ambient air prior to culture.
Charlie Mantel, a Research Associate, questioned whether or not the exposure of mouse bone marrow cells to ambient air, even for very short periods of time, were stressing these cells such that they were differentiating. After years of work by Charlie, Heather O'Leary, a post-doc, Scott Cooper, a Research Associate, myself and others in the lab, we became convinced that even a very short term exposure to air caused the rapid differentiation of HSCs to HPCs through a phenomenon that Charlie termed Extra Physiological Shock/Stress (EPHOSS).
Over five years of work by many different people, we were able to gain some mechanistic insight into EPHOSS, which acted through a Mitochondrial Permeability Transition Pore (MPTP)-Cyclophilin D- p53 axis, and involved the oxygen-induced release of reactive oxygen species (ROS). We also implicated HIF-1alpha and the hypoxamir, miR210 in this phenomenon.
AH: Do you think that the peripheral blood samples or cells from solid tissues types might undergo the same type of shock?
HB: We have not yet tested peripheral blood for effects on HSCs and HPCs, but my guess is that the same phenomenon of EPHOSS will apply. In fact as I added to the Cell paper with the permission of the Editor, I believe that this phenomenon will be broadly applicable to all cells in the body (stem, progenitor, precursor, and more mature), including tumor cells, that reside in an in vivo hypoxic environment. To get more insight into these thoughts see a subsequent review we wrote [2].
I do believe that EPHOSS will have broad impact on the metabolism of cells that normally reside in an hypoxic environment and are then collected and studied in ambient air.
If you think about personalized medicine approaches to cancer, and the need to evaluate gene or protein expression patterns and the response of these tumors and their cells to different modulating agents, it may be that the study of these cells in ambient air, even if they are subsequently placed into hypoxia, may not reflect the true state and responsiveness of these cells as they would be when residing in vivo. Thus, one might get a false or not accurate understanding of how best to treat the individual. This area clearly needs investigation.
AH: Do we need to go back and put a footnote on all previous studies that says "Performed in non-physiologic conditions," or some other cautionary note?
HB: Wouldn't this be an interesting thought? I seriously doubt that it will ever happen. However, it would be nice if others were able to follow up in this area for different types of cells.
Most important is the rigor needed in these experiments.
For example, we had to be very careful about air contamination in our experiments using the hypoxic chamber. Everything in the hypoxic chamber had to be pre-equilibrated to the lowered oxygen tension of 3% for at least 18 hours prior to processing the cells. This included glassware, plasticware, solutions, growth factors, etc. See the Cell paper for details.
The first experiments that were done were in a "RUBE GOLDBERG" type hypoxic chamber apparatus that Charlie put together himself that used duct tape to keep the oxygen levels in the chamber low, which gave us enough confidence in the results. But, it was not until we had a better more professional chamber that was more quality controlled that we got the reproducible effects we reported.
AH: There are costs to a researcher for abandoning their own methods after publication. Have you seen your recent findings inspire major changes by others?
HB: I have not yet seen follow-up on the hypoxia studies. I have heard from others that they are working on the use of cyclosporine A, as we noted in the Cell paper, to compensate the opening of the MPTP, so that the studies can be done in air. However, cyclosporine A is not an easy compound to work with as it is not easy to get into solution, and if cells are exposed to it too long in culture it is toxic.
We spent a long time finding the right concentrations of cyclosporine A to use for our studies and each investigator will have to work this out for themselves.
So in the meantime we are studying other compounds and means, without need for hypoxic collections and processing of cells to mitigate the EPHOSS effect which occur when these cells are exposed to ambient air.
AH: Why do you think, after a flurry of interest in oxygen in vitro in the 1950's, 60's, and 70's, that interest in oxygen had fallen off?
HB: This is like all science. It keeps moving forward which is what makes scientific investigation so exciting. Science knowledge moves on, as it should, and investigators like to be part of what is considered the next "hot" area.
Sometimes this is necessary in order to be competitive for publishing your work and attaining external peer-reviewed funding. However, sometimes, old areas reappear when a new advancement is made. I never left working in the area of hypoxia but now we are on to another aspect of this area, one that I feel is very important.
AH: How are your findings going to change the future of clinical use of hematopoietic stem cells and progenitors?
HB: This remains to be seen. I have been interested in cord blood transplantation since the early 1980s when I helped to initiate this clinical field. My lab continues to focus on basic science cell and intracellular mechanistic studies and pre-clinical animal models to better understand the regulation of HSCs, HPCs, and hematopoiesis in order to improve Hematopoietic Cell Transplantation in collaboration with our clinical colleagues.
We are working on different aspects of this, but one aspect is to improve the quality and quantity of collected cord blood, so that the cord blood banks have more potent cells to provide. Thus, we are currently following up on the results of our paper in Cell to find an easier, more simple and inexpensive means to counter the EPHOSS effect.
In addition to finding other means to collect a more potent stem cell population, we continue to study how to better engraft these cells. We continue to study the effects of dipeptidylpeptidase 4/CD26 and its inhibition, as well as a number of new small molecules to enhance homing and engraftment.
AH: Thank you for taking time to answer our questions here at the Cytocentric Blog. We look forward to seeing your work spread across the community.
HB: Thank you giving me the opportunity to respond to your questions.
1. Mantel, C.R., et al., Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock. Cell, 2015. 161(7): p. 1553-65.
2. Broxmeyer, H.E., et al., The importance of hypoxia and extra physiologic oxygen shock/stress for collection and processing of stem and progenitor cells to understand true physiology/pathology of these cells ex vivo. Curr Opin Hematol, 2015. 22(4): p. 273-8.


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Checked in at hairology and Mesh Body Addicts last night and found this really cute hair that is exclusive for the event. It's from no.match and lately they've been coming out with some really sick styles. One of my favorite things about this hair is that the mesh fits really well against the body and doesn't stick out to far like a lot of hair styles in SL does.
Next stop was the Mesh Body Addicts Event. I totally almost passed this outfit up..thinking that it was just another leggings and top that are at almost every single event lately. But this one from Cuddle Up is sooo cute and I'm glad that I tried the demos. These leggings have 4 different styles you can wear and I love every single one of them. Of course I love the cute little skirt the best..cuz I absolutely love having my ass hanging out =P I found a couple other outfits there and it was definitely worth the stop!
necklace~+Half-Deer+ NEKOlace
top~Cuddle Up - Kittie Top - @ Mesh Body Addicts
skirt/leggings~Cuddle Up - Kittie Leggings - @ Mesh Body Addicts
socks~Maddict Funsie Sock - @ Mesh Body Addicts
heels~fashionAtic Arely White Gun Slink Heels High /TMP ouch feet/ Maitreya


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Villas Inc Apartments
425 Worth Ave., Palm Beach, FL 33480
(561) 655-7050
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Street address:
425 Worth Ave.
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Palm Beach
Palm Beach
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(561) 655-7050
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Peter Mc Donald
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(561) 833-7022
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According to our records, this business is located at 425 Worth Ave. in Palm Beach (in Palm Beach County), Florida 33480, the location GPS coordinates are: 26.7012995 (latitude), -80.04199 (longitude). Villas Inc Apartments is categorized under Apartments (SIC code 6513). Known organization manager is Peter Mc Donald. Current estimates show that the unit has a sales volume of $1,980,000 and staff of approximately 10 people. You can contact the company by phone at (561) 655-7050; the following fax number is also provided: (561) 833-7022.
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Egyptian Cobra Loose in Bronx museum!!!Posted: March 29, 2011 Filed under: Museum News | Tags: Bronx Zoo, Egyptian Cobra Leave a comment
That's right folks, an Egyptian Cobra escaped from its enclosure at the Bronx Zoo on Friday and is now chillin somewhere in the World of Reptiles building, says a zoo official.
Yeah. Weird, right? I bet you forgot that Zoos are MUSEUMS!
According to the New York Times, we don't need to worry too much about our scaly friend:
A native of Africa and the Arabian Peninsula, the Egyptian cobra, or asp, can be deadly. But it usually preys on toads and birds, not humans. Its venom can quickly cause respiratory failure, and legend has it that Cleopatra used the asp's toxins to commit suicide.
But experts said cobras are generally averse to human contact and unlikely to bite unless they feel their lives are in peril. In this case, the snake's small size would make it even less deadly because its glands are smaller, said Rulon W. Clark, a herpetologist at San Diego State University.
"The actual danger in a situation like this is very low," Mr. Clark said. "These aren't animals that view people as meals."
So, yes, this whole cobra episode is relevant. And its also very funny.


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My friend and I were lucky enough to be the very FIRST fans ever to be inside Mallory's house. We were just going to drive by and take a pic outside, but happened to get invited in. It was such a great experience and Im so thankful.
( Pics this way!Collapse )
*Please do not ask me the location of Mallory's home. I did not realize that someone lives in the house until I got there and I would like to respect their privacy as much as possible after they were so gracious to me.


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Hey Heyyy There!
I'm Kristin, and I'm the writer and owner behind this little blog, Everythings Always Sunny. I started Everythings Always Sunny in May 2011 as a source of creativity and a place where I could write and share the things in my daily life that inspires me. If you've browsed around a bit, you'll see that fashion is something I genuinely love. I don't know what it is, but the way you dress can really express and show you and your personality, and that's something I really love!
I love to travel with my freaking awesome Fiancé, Matt. We got engaged last February and were planning our June wedding. He's pretty freaking cool If you stay around a bit you'll see him here and there.. :)
I'm passionate about life and genuine happiness; I am a firm believer of "If you believe, you an achieve." as cliche as that sounds Its the truth. I enjoy writing about positivity and little things that I've noticed in my life that have changed because of the power of positivity and I like to share those things and ideas with others.
Thanks for taking the time to read this and learn a little more about this happy blog. If you have any questions or would just love to say hi, e-mail me at email@example.com :)
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I got the idea to start this at the end of church today, so I didn't make good notes. I don't remember everyone's names and don't have all the details.
Sacrament Meeting
One of the speakers in sacrament meeting talked about Faith being an action word and cited James 2:14, 17
14 What doth it profit, my brethren, though a man say he hath faith•, and have not works? can faith save him?
17 Even so faith•, if it hath not works, is dead, being alone.
We also talked about this briefly in priesthood meeting.
Sunday School
We talked about Abram separating himself from Lot. Lot and Abram's workers were arguing over resources it seems. Abram had the right to choose, but he gave the choice to Lot. This could have cost Abram much money and advantage. To keep a good relationship with Lot he allowed this.
How do WE respond to conflicts with coworkers? Do we dig in and defend our positions or do we be kind and try to make sure that our coworker is uplifted? What about our interactions outside of work? What about the idea of defending our right to do this or that and losing sight of our responsibilities?
Sunday, February 26, 2006
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Roxy Jade Sunglasses
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Today was one of those days where I had a bunch of fun stuff to do like go to the gym at the crack of dawn, take a quick trip by the farmers market to gather some freshly picked leafy greens for my green smoothie of the day, take a trip up the highway to help a friend get started packing for a move and then back home for an appointment and now here in fron of my computer to write you this story.
It's one of those days that having green smoothies in my life really makes a difference. It is also very nice to be able to stop at just about any market, produce stand or farmers market and pick up my green smoothie ingredients for a vitamin rich quick drink that I can make on the go.
I have a really easily portable blender that I carry with me and all I need is a plug, my fruits and greens and a glass and I am free to blend wherever I am.
There is a picture and info link at the top of my blog here to the blender I use which you can learn more about at my site at http://www.thegreensmoothie.com/. I use this Blend Tec blender because it is the most powerful blender on the market and I like to blend up things like avocado pits for their high soluable fiber value. This blender turns the pit into the smoothest drink immaginable and I love it!
So I'm out there on the road after a work out, I haven't had a bite to eat cause I like to start my days out with a bunch of fresh clear water, and now I'm beginning to feel the need for some nutrition.
I've got my blender with me and a bag of blueberries, bananas and an apple so when I get to my friends house I just blend up a green smoothie. It's as simple as that.
That is what I love. It is so darn easy!
I get about a weeks worth of greens and fruits in my body by most peoples standards and I immediately feel like a million bucks, energized and ready to pack and move boxes. Fun! And I do this everyday no matter where I am.
It's a wonderful thing the Green Smoothie and they taste so good that it's never an issue of forcing down some terrible tasting green drink. They are pretty crazy green looking but the fruit in the smoothie always overrides the taset of the nutritious leafy greens.
Give them a try! Get your kids to drink them. I guarantee you will feel great and your health and your childrens health will improve.
Here is a good site to start with: http://www.thegreensmoothie.com/
Let me know if you have any questions!
Here's to your Health!


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Yesterday I was a little quiet in the blogosphere, a little quiet in the head-o-sphere as well. It was necessary, because actually while "I" was quiet in my head, my demons and devils were pursuing me with all of their might, desperately trying to pick a fight, desperately trying to make me do something I would regret later. What I have learned over the past 2 weeks: when being chased by demons and devils, please do not do what they are asking you to do!
How incredibly funny, really, that I could ever think of following the guidance and advice of the thoughts in my head that have my well-being at the very bottom of the heap. And yet I've done it so many times. When I follow those thoughts to their ultimate conclusion, deep down into their rabbit holes where no light or sunshine or God's radiance is visible (though it is there!), all that is visible is the despair, all that is visible is how deep in trouble I've gotten myself. And man, that just sucks.
The demons and devils yesterday were playing this fun game with me: anybody I love (locally) who I haven't heard from in the past oh, say, 15 minutes, or if I've called them or sent them a text or an email and they haven't gotten back to me yet (because they are busy and have lives) and I do mean quite literally in the past 15 minutes, my demons will catch hold of that person's name and love and memory and they will start to torture me with it. "this person hasn't called you back because they don't love you anymore. they have found out the truth of who you are, they've seen right through you, and they don't love you anymore. don't you want to find out if that's true? don't you want to confirm that your worst fears are true? i promise you, if you reach out to them and tell them everything you're feeling right now, they will verify it. they will. that's why they haven't called you back. they want you to go away and leave them alone." Scary, isn't it? It was that kind of energy that made me post the entry that did, in fact, really damage one of my favorite friendships - expressing my worst fears, which had absolutely nothing to do with my deepest experiences.
A few years ago, I was doing some research on narcissism after being exposed to a pretty powerful narcissist (who was such an incredibly important player in my life, who still is. I have a whole novel dancing in my head about this magician. I'm so thankful for everything he's done for me!), and I read that there is a sub-type or a sub-clinical symptom or something like that in the narcissistic personality spectrum in which the personality assumes a degree of "invisibility," as in they don't consider themselves memorable and so they assume that the people around them do not have a thread of connectivity or recognition towards them. They assume that they will be forgotten, and they do not expect that people will recognize or remember them, even after many exchanges, and they do expect that even people who have claimed to love them will forget about them - out of sight, out of mind. This manifests in behaviors like the long-suffering do-gooder (and that would be me), or in the big, puffed-up, attention-seeking-and-hogging classic "narcissist" who is doing everything in his or her power to make sure that they are remembered.
It's taken me a long time to admit that I recognized myself in the description of a narcissist, even in that tiny bit. I do assume that people don't remember me. Over the past few years of living in my new adopted city, I have made more of an effort to connect with the random people I exchange with - my juice guys, my whole foods guys, etc. - as well as with my clients. Being afraid to be forgotten, I have a frighteningly good memory with names and faces, while always keeping my own identity somewhat anonymous. But what this means with my demons and devils is that they torment me by telling me that I will be forgotten. Not just remembered poorly - FORGOTTEN. Out of sight, out of mind, baby. And as a result, I am terrible at staying in touch with long-distance friends, because I assume they have forgotten me. Seriously.
Now, I don't have this misconception to a pathological degree - just to an inconvenient degree. I'm very glad to have seen it, both in that website and in my own behavior, because it has helped me get over it to a very large degree, to the point now where it's pretty laughable. Until I have a day like yesterday, in which there is panic and fear and a sense of loneliness and isolation and not-knowing, and it's not so funny anymore. Or, rather, it's even funnier and I don't get the joke.
Summer of Self-Care - Nothing like the discipline of a 40-Day challenge being thrown in the mix to keep me on my game amongst parties, BBQ's, vacations and the general hedonis...
5 years ago


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Explaining Minnesota's 'hidden' pension problem
It's been called Minnesota's hidden budget deficit.
The state's pension plans — which cover retirement benefits for about a half a million teachers, fire fighters, police officers and other state and local government employees in Minnesota — are underfunded by billions of dollars over the next several decades.
It's not a new problem: Minnesota has had pension liabilities each year for nearly a decade. But pension issues are often an ignored story, even as problems with the plans are starting to affect credit ratings and the everyday work of state and local governments across the country. Without a solution, ultimately, taxpayers are on the hook to cover what the state can't.
"It's this sleeper issue," said Susan Lenczewski, executive director of the Minnesota Legislative Commission on Pensions and Retirement. "Right now it's a long term problem that we all can ignore, but it has this compounding effect."
Here's a breakdown of how the state's pension system works, how politics affect it — and what could happen if the system's funding shortfall isn't addressed.
How are pensions different from my 401(k)?
Pensions are a retirement benefit most commonly offered in the public sector, and they're considerably different from the retirement benefits most private sector workers receive. As a so-called "defined benefit" plan, a pension is a promise between an employee and an employer to receive a certain amount of monthly income after retirement. Most private sector plans, like 401(k)s, are defined contribution plans, which allow the employees to pick and choose what and how much they invest — with no guarantees on future income. Pensions put the investment risk on the plan provider, or in the case of public employee plans, the government.
So everybody who has any sort of government job is in the same pension plans in Minnesota?
It's not that simple, and there are a lot of acronyms involved, so bear with us. State employees are covered by MSRS, or the Minnesota State Retirement System, while local government employees are covered by the Public Employees Retirement Association, or PERA. But neither of those includes teachers, who are covered under a third plan, the Teacher's Retirement Association — or TRA. Well, all teachers in Minnesota except those who work for St. Paul Public Schools, in which case they are part of the Saint Paul Teachers Retirement Fund Association, or SPTRFA. Got all that?
How is the pension calculated?
Generally, after three to five years of employment teachers and government workers are eligible for a pension. The basic formula to calculate those benefits is fairly simple. An employee's pension is determined by multiplying the number of years they've worked in a state or local government by their average salary over their five highest-earning years by a so-called "multiplier." Currently, the multiplier is 1.7 percent for most government employees and 1.9 percent for most teachers. There are some exceptions to those multipliers, but they cover most pension holders.
So if a public elementary school teacher worked for 25 years and made an average of $61,000 during his or her highest paid years the state would pay them about $29,000 per year after retirement for their pension (25 x $61,000 x 0.019). Those benefits don't start kicking in until age 65 or 66, depending on what year the employee started, and continue until the person's death.
Ok, so what exactly is the problem?
This is where pensions get more complicated. The funding for pensions is based on professional predictions about how much governments and workers need to pay into the system to cover pensions long into the future. In Minnesota, professionals invest workers' contributions and use those gains to help pay for benefits.
But predicting the future is not easy to do. Over the last decade, the assumptions that public pension managers made in other states were overly optimistic. Complicating things in this state: Minnesotans are living a lot longer than people expected. The average Minnesotan now lives to be about 81.1 years old, the second highest life expectancy in the nation, after Hawaii. And that number is expect to rise, meaning the state could be paying out pension benefits to some retirees for decades.
Got it. Minnesotans never die. Any other issues?
Another term to remember when it comes to pensions is "funded ratio," which is basically a percentage that tells a state if they have enough money to pay for all of the pension benefits they've promised to pay out. A 100 percent funded ratio, for example, would mean the state has the same amount of assets as it does liabilities. As of July 1, 2016, nearly all of Minnesota's pension plans were under 100 percent, and together averaged a 77 percent funded ratio, which translates to about nearly $18 billion in unfunded liabilities. But these numbers are nearly a year old, Lenczewski said, and investments are picking up. The next snapshot will come on July 1, when professional money managers give the state an update on the health of their plans.
That's a big number. Does the state need to fix it immediately?
Not right away. Pensions are paid for over a long period of time. But unless there's a sudden spike in the return on investments, it needs to be dealt with eventually, and those looming unfunded liabilities can hang over a state's credit rating. "Moody's, Fitch, they're all looking at this," Lenczewski said. "It does have an impact. It's called out in their review of the state." A pension plan is in a "death spiral" when it hits 35 percent funding or less, Lenczewski said. Minnesota has done better than many other states in keeping its liabilities on the manageable side, especially after a 2010 pension law spread out the burden of unfunded liablities between retirees, active public workers and public employers. Other states, like New Jersey and Illinois, are facing much bigger pension problems, with more than $100 billion in unfunded liabilities.
Another thing to remember about pension plans: They're a promise from an employer and an agreement based on work already completed, which means the state can't back out because they don't feel like paying.
So who's working on this?
Like so many things involving state government, pension issues are decided by committee of legislators — equally divided between the House and Senate — that's tasked with addressing problems or making whatever changes to the pension system are needed each year. This year, legislators wanted to start dealing with the low return on current investments and the increased life expectancy of retirees. The proposed pension bill would have:
- Reduced and suspended some automatic pension cost of living adjustments, also known as COLA
- Lowered the investment return assumptions from between 8 and 8.5 percent down to 7.5 percent
- Increased employer and employee contributions
- Contributed millions of dollars in direct state aid to help reduce costs for state government employees, police and firefighters and St. Paul Teachers (though not for other teachers or local government workers)
What happened to the bill?
Like everything else at the Capitol, pensions are subject to the whims of state lawmakers. In 2016, Gov. Mark Dayton surprised many when he vetoed the pension bill after lawmakers went home, saying it didn't do enough to address liabilities and put too much burden on retirees. Since then, Dayton convened the Blue Ribbon Panel to look at tackling pension issues in the state.
But this year, the pension bill got wrapped up in end-of-session politics. In an effort to get Dayton to sign a bill Republican legislators wanted — to preempt local governments from setting their own minimum wage and labor laws — they attached it to a bill with things Democrats wanted, including wage theft protections, paid parental leave benefits for state workers and, yes, the proposed changes to public employee pensions. "The role of state government is to set minimum standards for workplace protections, wages and benefits, not maximums," Dayton wrote in his veto letter.
There's also the problem of pensions getting caught up in the debate over public unions. The pension benefits for public school teachers were the subject of much debate this session, and the plan was eventually carved out of the pension bill altogether.
It can also be hard get state workers to get on board with reforms to the pension system, as changes can be seen through a lens of attacking unions and state workers. In Minnesota, public workers contributions cover roughly half the pension costs.
So what happens next?
Probably some déjà vu. After Dayton vetoed the 2016 pension bill, lawmakers came back with that proposal in 2017 and started their work there. People watching the issue again can expect legislators to start where they left of this year. The legislature is next scheduled to convene on February 20, 2018.
Sen. Sandy Pappas, DFL-St. Paul, who sits on the pension commission, said something needs to be done soon. "The important thing is you have a pension when you retire and you don't want to run it into the ground," she said. "Every year, you spend more and take in less than is affordable. It's going to cost the school districts more, it's going to cost the teachers more, and the same thing with the police and fire and state employees. It's just going to become more expensive to fix the problem down the road."
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Minnesota liberals - a term which describes almost all writers for and readers of Minnpost - always like to compare their enlightened state with the Neanderthals to the east. The claim is that DFL policies have resulted in MN having a stronger economy than in WI. No doubt that the MN economy has been healthier than the WI economy for 20+ years - even when MN has had Republican Governors and WI has had Democratic Governors. The main reason for the superior MN economy is that WI has always had far more mass production manufacturing than MN, and when that economic sector downsizes due to globalization and automation, WI suffers far more. All economists across the political spectrum know this fact, although most journalists seem not to.
WI, however, has a major long-term advantage in one area: their public employee pension systems are fully-funded, and are structured so that they won't require huge future tax increases to make good on their promises. That's a tribute to bipartisan fiscal responsibility, where the vast majority of elected officials haven't siphoned off employer pension contributions for other purposes (the one exception is Gov. Tommy Thompson, whose attempts to divert pension contributions were overruled by state courts).
In the not distant future, many states will have to raise taxes significantly in order to meet pension obligations. Wisconsin (and South Dakota) won't. Illinois will, which is why many employers there are already fleeing to WI to avoid the inevitable major tax increases.
It's not so simple
The WI state pension fund is fully-funded, thanks to those who took steps decades ago. COLAs can be clawed back, however, as part of the "shared risk pool". And unions have lost almost all collective-bargaining rights, which isn't necessarily a good thing overall.
Local governments are facing billions in unfunded obligations, unfortunately, and there are state-imposed caps on local levies - you know, the GOP tactic of pushing things downstream.
More to it
This is a well done primer on public pensions. In the opening paragraphs law enforcement is not addressed. I believe that they have the shortest full retirement period and get 100% of their salary-very different from other public employees if this is true.
There is even more politics. For years Minneapolis and maybe St. Paul legislators short funded the pensions in those cities while designing them to offer higher benefits than the suburban/out state TRA. They instead put the money into MPS salaries (indirectly of course) with the idea that somebody would make up the difference some day. The Minneapolis fund went bust, merged with TRA and MPS teachers were allowed to retain their generous pension benefits. Many teachers feel that the restrictions on COLA's etc are due in part to this sleight of hand by Minneapolis legislators. If true it is another shameful example of shady politics.
MSRS Part
I retired after 22 years of State service. During those years some bargaining groups encouraged members to contribute to some supplementary retirement fund, because the State, while obligated to match each enployees retirement deduction never actually put any money into the investment pool. That is, while the employees payroll deductions went into the investments pools and gained earnings, the State had no money in the pool and so earned nothing. Every two years the legislature would appropriate their estimated fair share. But they always low-balled. we now see the result. The oensiin funds are in trouble becaysevof State cheating. Typical for Republicans, they have always hated the working class.
Hammer Meets Nail Head
You nailed it Mr. Ferman. The taxpayers, via their elected representatives, have not funded the promises made. A pension is no more than an agreement between employees and an employer to live below one's means in order to have a economic security in retirement. Every financial planner recommends this practice.
I wonder if a building trades model of pension plan would be less susceptible to under funding by politicians. In the building trades model, employers contribute a set amount per hour to the pension fund, payable monthly. Half of the trustees are from the employer side, half from the labor side. Trustees set the value of pension credits, raising the value of a credit when it justified by in vestment returns, increased contributions, and advice from actuaries. There is no "guessing" by legislators of how much they will need to contribute, with obvious incentives to guess low. So every month, the state/city/school district would make their matching contribution.
I much prefer my private industry pension to a government pension. A public employee may tell me that their annual wage/salary is say $70K/year. But they lose somewhere around 6-7% of that off the top to contribute to their pension. My pension contribution is made entirely by my employer; it's in addition to my wage.
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I, therefore, the prisoner of the Lord, beseech you to walk worthy of the calling with which you were called… Ephesians 4:1
I don't know about your pastor, but my pastor always says, "Whenever you see the word 'therefore' in the Bible, you should always ask, 'what's it there for?' " That just makes sense, doesn't it?
It's here (this time) because the Apostle Paul wants to remind us to sit down before we walk. More accurately he is saying that before we can walk out our faith we need to remember where we are seated and how we came to be there.
Two chapters earlier (in Ephesians 2:5-6) Paul writes:
When we were dead in trespasses, (He) made us alive together with Christ (by grace you have been saved), and raised us up together, and made us sit together in the heavenly places in Christ Jesus…
Walking effectively in Christ begins when we understand what He has already done for us, realizing that we had nothing to do with it, and (most importantly) that He finished the work on the cross. When we can appreciate this truth our walk becomes a response to the love He has already demonstrated. When we fail in this regard it's our tendency to wander without purpose [because] we're being fueled by something other than Christ's love.
Here's a nice summary (found in 2 Corinthians 5:14a and 1 John 4:19):
For the love of Christ compels us (and) we love Him because He first loved us.
Our Christian walk is a response of gratitude. Our reward is not so much for what we do as we walk, but the walk itself. In other words, we get to walk; Jesus genuinely has a use for us! I am so thankful that the Lord plucked me from the pig-sty that was my life, gave me a seat in Heavenly places, and now allows me to walk-the-walk. My need to share Him with others is not an obligation; it is a most reasonable reaction to His love.
As it is written: "How beautiful are the feet of those who preach the gospel of peace, Who bring glad tidings of good things!" Romans 10:15
- What do these verses tell us about God?
- What do they say about us?
- Are there changes we can address?
Related articles
- A Proper Love (compassiondave.wordpress.com)
- Greg Laurie: All Christians Are Not Disciples (airocross.com)
- The power of prayer. (thenoiseinmyheadtoday.wordpress.com)


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FACT: We are a bunch of impatient crazies. AND WE KNOW IT.
Mockingjay Part 1 has only been out for just shy of two months. It doesn't even have a confirmed DVD release date yet (in fact, it's still in many theaters) and yet we're sitting here, arching our eyebrow and looking toward Lionsgate as if to say "Soooo.. Got anything from Mockingjay Part 2 yet?"
Well, there's good news and bad news when it comes to that urge!
The good news? Tim Palen, Chief Marketing Officer for Lionsgate, will soon be releasing a photography book focused solely on the series! Here are the details:
This is pretty awesome because Tim Palen is the photographer behind some of the most iconic Hunger Games franchise images out there, including all the awesome character posters. He's been around the franchise since its beginnings and has got never-before-seen goodness, which is NEVER a bad thing!
The bad news? This will likely be our first taste of Mockingjay Part 2… and it's not coming until JUNE 2015.
We expected to wait until at least April for the goods. Lionsgate is going to be chugging through the INSURGENT release until the end of March, after all. We can wait for one this to die down before the company worries about another.
Tim's book will likely mark the very first peek into MJ2. The main photography is his work, so it;s likely going to be released in support of the book. Releasing his work early enough that it's not considered "in conjunction" with the book would be super contradictory to the book's whole purpose– TO GET OUR MONEY (and to display some lovely art). This also means the majority of MJ2 images from the book probably won't (officially) hit the web. Because again, they want us to purchase the book. Which you can do here, if you're interested.
Does they mean we're doomed to another year with no real Mockingjay media until late August? We don't know if we can stand that pain once again! Clearly it didn't work out so well last time, so let's not repeat it, okay?
We Can Be Patient. Just Not THAT Patient.
The Girl With The Pearl


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Halmahera Wasile Bay Nature Reserve
0-ª15′-0-ª35'N, 127-ª53′-128-ªl0'E; Kabupaten Maluku Utara, Halmahera, Moluccas.
Sea level.
Description of site:
A shallow sea bay and estuarine system with mangrove swamps and sandy beaches, in the central part of Halmahera. The bay is surrounded by a coastal plain varying between three and ten km in width.
Climatic conditions:
Humid tropical climate.
Principal vegetation:
Mangrove forest with Bruguiera spp, Sonneratia alba and Heritiera sp, and beach forest with Corallia brachiala, Callophyllum inophyllum, Barringtonia sp and Calamus sp. Lowland tropical rain forest in adjacent areas.
Land tenure:
State owned (Indonesian Government).
Conservation measures taken:
Conservation measures proposed:
The entire area has been proposed as a Nature Reserve.
Land use:
About 5,000 people live in the lowlands around Wasile Bay, near the proposed reserve.
Disturbances and threats:
Illegal cultivation, development in transmigration schemes, particularly in coastal areas, and timber concessions.
Economic and social values:
No information.
Little information is available, although the area is known to be rich in endemic species. A variety of waterbirds has been recorded including Fregata minor, Nycticorax caledonicus, Bubulcus ibis, Dendrocygna guttata, Tadorna radjah, Pandion haliaetus, Esacus magnirostris, Numenius minutus, Tringa nebularia and Sterna anaethetus. Mammals include Pelaurus breviceps, Macaca sp, Sus scrofa, Pteropus sp, Paradoxurus hermaphroditus and Musaderma spasma. The Estuarine Crocodile Crocodylus porosus is known to occur.


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Sport is one of ways how people can relax, consume their energy and secure their health. Some people are sports fans but don't do sports, they watch sports programs on TV and cheer for their favorite sportsmen, read newspapers and listens sports news on the radio. But some people do active sports for their health, their pleasure or maybe to earn some money.
Sports can be divided into two groups- individual sports where person is taking part by himself and team sports where group of people are working together to achieve the their aim.
Long jumping, high jumping, running, horse races, skating, skiing are individual sports, where people demonstrate their gifts. …
Tavs vārds:
E-pasta adrese, uz kuru nosūtīt darba saiti:
Saite uz darbu:


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By Adam Hensley
Iowa baseball (29-17) gets another chance to move up in the Big Ten standings as Ohio State (19-30) travels to Banks Field for a three-game weekend series.
Today's game will begin at 6:05 p.m. Tickets are $7 for adults and $3 for youth. For fans who cannot attend, the game can be viewed on BTN2Go.
Iowa, tied with Michigan for fourth in the conference, will play its second-to-last Big Ten series of the season against an Ohio State team sitting at 6-12 in conference play.
Recently, Iowa took care of business in East Lansing, Michigan, when it took two games from Michigan State.
Tyler Cropley's single drove in the game-winning run in the top of the ninth, putting the Hawkeyes up 3-2 for good.
The third game proved to be a stark contrast from the previous matchup; the teams combined for 23 hits, more hits than in the first two games of the series.
After Iowa led 4-0 through three, Michigan State charged back, scoring 4 runs to cut the Hawkeyes lead to 5-4 headed into the ninth.
The Hawkeyes didn't back down, however, and scored 4 runs of their own in the final inning.
"It was another close game heading into the ninth," Heller said in a release. "It was good to see us break through and score some more runs."
The Michigan State series, a momentum-builder late in the season, came after Iowa recorded a major confidence booster against Penn State, its first Big Ten series sweep since 2015 against Minnesota.
The Hawkeyes beat the Nittany Lions 4-2, 8-2, and 9-1. The final game featured Jake Adams' 16th home run of the season. Adams' homer was a cherry on top of a series filled with weather delays, time changes, and a double-header, which lasted until almost 1:30 a.m. on April 29.
"You just got to keep your composure," Adams said. "If I would have let [my strikeouts] affect me, I probably would have went up there and struck out another time."
Keeping said composure and momentum will be key for Iowa, even as it faces opponents with losing records.
Despite almost polar-opposite records, the Hawkeyes can't afford to overlook the Buckeyes. As Hawkeye fans recall, they dropped two games to Rutgers, a team which Iowa should have taken care of on paper.
Anything can happen, especially late in the season.
Ohio State beat Oregon State, 6-1, on Feb. 24, and the Beavers are currently the No. 1 team in the nation. The Buckeyes also took games from Purdue, Michigan State, Nebraska, and No. 16 Michigan.
A sweep would do Iowa wonders in the conference standings. Iowa, Michigan, Minnesota, and Maryland remain within a game or two of each other for the second spot in the Big Ten.
This all comes after the Hawkeyes found themselves sitting at 7-6 through their first 13 games of the season.
"Throughout the course of the year, I think this team's grown a lot," Matt Hoeg said after Iowa's win against Penn State.
The Hawkeyes will travel to Champaign, Illinois, after their series with the Buckeyes. Ohio State and Illinois have combined for 13 Big Ten wins this season, just two more than Iowa has.
Even though the opponents aren't as highly rated as previous foes, the stakes are at the highest they've been.
The opportunity is there, and realistically the Hawkeyes could very well sweep their remaining Big Ten opponents. Nothing is given, however, and Iowa needs to take care of business in order to fight for a top-three seed in the Big Ten Tournament.