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I hope everyone is having a fantastic Thanksgiving! I thought I'd share some Thanksgiving photos for today!
Here are some turkey cupcakes I made!
And some from-scratch dinner rolls my sister-in-law made! Mmm don't those look delicious?
Enjoy your time spent with your loved ones! What are you thankful for today?


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The third field trip we took last week was with the homeschool group to the Columbus Museum of Art. The last time we were there, the entire museum was undergoing renovations. This time, the remodeling is finished, and the museum looks spectacular! In addition to the wonderful works on display, there is now a large (and very fun) children's area, as well as children's activities integrated throughout the museum's regular exhibits.
As always, comments are welcome, either here or on our facebook page. Let me know you're reading along!

subset: commoncrawl


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Thursday, August 20, 2009
I'm ready to paint my wall
Hi all, okay, the project has begun. It is really just a small project but I have been meaning to do this for a couple of months now. I have one wall in my living room/dining room area that I want to repaint and redecorate. And for my birthday I picked out this gorgeous old shabby chic head board at a local shop that has been made into a blackboard, as my gift (thank you mom and dad). I'm actually staying with my signature color of Creamy Brie for the wall because I already have the opposite wall painted in a golden yellow faux finish and I don't want to compete with that so......
I should be finished with the painting in a few hours so I'll leave you all with the beginning photos here and then later I'll post the finished results. Wish me luck, lol.
talk to you soon,
Posted by starrynightimpressions at 3:56 PM
6 comments:
- ArtSnark said...
Love the headboard - gorgeous! Looking forward to your after shots :D
- August 20, 2009 at 8:40 PM
- TinyBear said...
Looks great - can´t wait to see the finished result.
- August 20, 2009 at 10:58 PM
- Lenore said...
I'm looking forward to seeing the result...good luck.
- August 21, 2009 at 5:39 PM
- Shari Replogle said...
HI Deborah!
I love the headboard/chalkboard , it is beautiful. I am just doing a little catch up . I Loved the photos of your garden as well. They were gorgeous.
- August 25, 2009 at 7:09 PM
- Denise said...
What a great headboard. Look forward to the finished room pics.
- August 29, 2009 at 5:13 AM
- Fete et Fleur said...
It is going to be beautiful I'm sure. Please post pictures when you are done.
- September 9, 2009 at 7:44 PM
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Also: Monday, Labor Day Noon Swim
Last Swim: Saturday 9/3 Noon
Water Temp: Top four inches 70, below that 60 maybe
Waves: Calm
Water Clarity: Very Good
Crew: Cap'n, Crash, Diablo, Kahuna, Speed, Mike, Eric, Patriarch
All are welcome to stop by my house after Sunday's swim, 4433 N Woodburn, Shorewood. Bring your friends and family too. The menu will be brats, burgers, and corn on the cob. Refreshments will include beer, diet soda, LaCroix, and of course Killepitsch.
What to bring: you don't really need to bring anything, but I may not have enough chairs, so if you have a portable lawn chair please bring it. Wine if you want it. Desert stuff might be nice.
Also, to be sure I have enough food, it would be helpful to let me know you're coming by posting a comment, or calling or emailing or smoke signal. Thanks.


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On an uncrafty note....
I just found out that my friend's husband, Russ, (in the middle) is returning to the next season of (my favorite show) Survivor. He was on before but collapsed and had to leave. He didn't finish the game the way he wanted, something that he dreamed about like forever and then to have it end the way it did....well, just left things unfinished. I am so happy for him that he will be able to get closure on this. Of course, I don't know how it all ends. I know he is home so I guess things didn't get too bad. They sign legal documents and stuff and can't talk about it so my friend can only smile at me when
I think I may want to do this one day. Great way to lose weight right...I'm in! Oh, but the bugs and other little creatures...let me think about it a bit more....OK maybe the Amazing Race instead. Any takers on being my partner????
Ok onto the crafty part of today's post.....more swaps from Stampin' Up!'s convention
|Beverly Kissler
|Dana Homer
|Rita Falquette
|Holly Middagh
|Nancy Meyers
|Christy Sauer
|Lydia Thompson - Rebecca Waddell
|Sandi Hutton
|Sue Scheets
|Add caption
|Jinnae Morgan
|Jolene Jacobs
|Janine Allen


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Code § 24.2-233 states that "Upon petition, a circuit court may remove from office any elected officer or officer who has been appointed to fill an elective office, residing within the jurisdiction of the court."
Here's how the recall effort works.
Step One: Gather Signatures
A petition detailing the reasons for removal of the elected official must be circulated, and at least 10% of the people voting in the last election for the office being recalled must sign the petition.
Step Two: Court Rules
Upon submission of the signatures, a state Circuit Court will then inform the elected official and hold a trial.
Step Three: Replace the Recalled Official
The normal procedure for holding an election to fill the vacant position will be followed.


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My two new spindles from Lisa arrived this week – so I now have a total of three Gripping Yarn spindles. Here's a nice family shot:
On the right, you can see my Black Palm Rose – my two new spindles are, in the middle, another Rose, made from Cherry this time and on the left, a Birds Eye Maple Russian. I wanted to get a Russian, so I can try truly "spinning off the tip" which is harder to do with a French style spindle with the wider tip. I also wanted to get a much lighter Rose, so I can use it handheld for twiddling and making lofty, thick singles in the French style. It also gave me an opportunity to purchase one of Lisa's copper caps, so that you can also use the spindle suspended.
Time for some pics.
This Cherry spindle weighs only 19g – so it's super light. I was hoping to get one in African Mahogany, which is slightly lighter, but the spindles didn't come out balanced – and the Cherry is beautiful.
You can see the copper cap – it weighs about 6g and is malleable enough so that I can tweak the end if needs be.
The Birdseye Maple Russian weighs 30g – I'm hoping that with this I might be able to get to grips with the simultaneous spinning and drafting technique that I've attempted. I'm getting to be pretty decent at long-draw via park-and-draft, so it would be nice to add another technique to the arsenal. The wood has a beautiful grain – with maple stripes, as well as the little birds eye knots. This was my surprise spindle – I asked Lisa to make me a Russian out of a blonde wood and this is what she came up with. It's gorgeous and so well balanced.
And my Black Palm Rose. It's actually quite a bit shorter than the other Rose – and weighs 34g – it's been a lovely starter spindle and does spin beautifully.
I don't think I'd want to spin everything supported – for me it's still a little slower than suspended spinning and for things like sock yarn, I'd want to be able to spin a worsted-style yarn. So my other spindles will get plenty of use. But certain fibres in my stash were made to be spun this way. Camel, cashmere, angora… I have a couple of 100g merino/angora 50/50 braids that I can't wait to spin up into something lofty and soft.
Time to get off and practice! 🙂


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JOURNAL TOPIC: [today's tunes: "Ice Cream Man" by Van Halen; "'S Wonderful" by George Gershwin/performed by Ella Fitzgerald]
I just wrote a draft of an article that got me thinking about ice cream cones. Describe in detail your most memorable ice cream cone moment.
1. Journal
2. Socratic/class discussion: masterpiece presentation requirements
1. Read/do/think something wonderful and post (title: S' WONDERFUL)


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I often see some original design on sale from Aliexpress, which are remix of other open hardware designs or brand new things. When I can I will make all efforts to try to find the original design, to support the inventor.
Price, indication and images may change without notice.
ATmega32u4 usb development board ~4,80€
This board has inside same processor as Leonardo and Micro, which means it doesn't need at all a USB-serial converter, can do input as mouse or keyboard, and can be plugged directly on a usb port.
As a simple project you could make a password manager. Or a monitor auto brightness adjustment.
It runs at 8MHz instead of 16MHz, but I'm sure that for most projects it doesn't matter as it can listen to buttons, do math, give commands and have plenty of cycles remaining.
AtTiny85 development board ~1,40€
These little boards are the closest you can get to a plug-play-deploy arduino you can get. While they can be programmed with Arduino IDE, they need an addon, don't support Serial, and have >8Kb flash for programs.
Anyway, if you just need a simple driver chip for a beeper, flash some lights, testing a servo, or a PIR sensor these are for you.
Can be combined with a battery that has a usb output to make a project on the fly, like a PIR sensor with a buzzer to warn if motion happens.
The original design comes from Digispark, and was remixed and improved by Adafruit.
NodeMCU V2 ~6,40€
Even if it is not the cheapest NodeMCU boards, these have a smaller width, so they can fit on a breadboard, and have a spare row to plug in male jumpers.
Compared to ATmega based Arduino boards it is a whole new world:
-1Mb Flash memory for program and data-80MHz speed
However to get these bonus you lose 5v pin compatibility, only 1 analog pin which doesn't stand more than 3.3v, less pins, no 5v regulator.


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Real-estate listings and data company, Trulia, says that home-listing prices were up 5.1% nationally in December on a year-over-year basis, according to data released Thursday. Stefanos Chen of the Wall Street Journal wrote that out of the 100 major metro markets covered by the report, 82 of them saw year-over-year gains. At the end of 2011, asking prices had fallen 4.3%, and only 12 markets had posted positive price changes.
"Prices are going into 2013 with strong tailwinds," said Jed Kolko, chief economist for Trulia. He cites a general strengthening of the job market, which in turn means more families able to cover a sizeable down payment. An increase in household formation, which is also the product of improving job prospects, and home construction could further bolster demand.
James Mosher of The Bulletin in Norwich reported Wednesday that Home sales in New London and Windham counties rose 16 percent last year from a year prior, according to the Eastern Connecticut Association of Realtors. Total combined units sales were 3,837 in 2012 compared with 3,308 in 2011, the Franklin-based association said.
Read more: Eastern CT housing sales up 16% in 2012 – Norwich, CT – The Bulletin http://www.norwichbulletin.com/news/x1058229048/Eastern-CT-housing-sales-up-16-in-2012#ixzz2HbiOyM6k


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Your help is urgently needed in this suffering country, where 80 percent of the people survive on less than $2 per day."
World Vision is a trusted Christian humanitarian organization that was founded in 1950. It works to provide poverty-stricken areas around the world (including the United States) with basic necessities for survival such as clean water, sufficient food, medical attention, and other services. This organization is dear to my heart, and I've been engaged in their work since my freshman year.
The DRC is in desperate need of relief, and your financial contributions can be of great influence under the hands of World Vision.
If you choose to donate, the women and children who have suffered years of violence and unimaginable pain will receive your gift, which multiplies 9x in impact. Your donation will go towards reliable sources ( sustainable crops, healthcare and medical support, and agricultural resources)
If you are moved to contribute to this worthy cause, I would like to say thank you in advance.


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Correspondence relating to the International Festival of Youth Orchestras in 1974 (which was to include a performance at Sadler's Wells on 18 August). Appears to be file of Derek Westlake, Administrative Manager and of Douglas Craig, Administrator.
International Festival of Youth Orchestras 1974
- This material is held at
- ReferenceGB 1032 S/SWT/2/6/154
- Dates of Creation1973-1974
- Physical Description1 folder
- Direct Link


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We hope, you do recognize how meaningful beforehand PC protection is and how epic backup's part is. The backup industry provides a set of tools which offer every kind of backup benefits one can think up. Is there a possibility a user may painlessly create his way through this wood of utilities and find a truly meaningful tool? Let's see the opportunities.
One of the first steps to find its way to a head is following to big giants. Acronis, NovaBACKUP, and other brands seem to have amazing customer networks. Doesn't that imply I may also believe their backup solution, if there are so many clients already?
Another direction, a little more time for selection, but also a more safe one, is to test specific working features. Knowledge axiom, but where am I supposed to begin from, one might rightfully ask himself? There those limitless backup software directories, how do I find a window in this world of night?
The latest Recover Lost Photo review 2012 is about must-know options of todays backup solutions. Remembering those will surely enlarge your successful possibility to discover a really awesome backup tool.
In the market of backup software (in the usual IT world also) there is a strong axiom the developers often stick to: earn more for less. Way far too often there is a solution which requires additional fee for creating even key options accessible. Here is a good example: Recover Lost Photo.
For instance, you get the program which is only capable of backing your files up. To recover it you need to purchase something else from the same provider.
Another trouble to a happy living is the unhappy circumstance that present backup programs often deal only with the mainstream systems (Windows 7 or Vista) and don't deal with less common but important ones (e.g. Windows Server 2008). This makes those utilities of tiny use for many business purposes. Just like at Acronis.
At last but not least, many backup program utilities require advanced user skills. With some programs there are cases when you must reboot under another Os to create a hard disk image or you find yourself killing tricky small procedures by hand. If there are any negative traditions in the world of backup program tools, unluckily this is definitely one. E.g. check Handy Backup: perfect features, but minor opportunities for beginners.
Thence, in order to be sure a backup software can do data you want, it is always useful to check what it can't back up. This sort of information tends to be hidden, as no sane manufacturer won't be showing you in public what exactly the mistakes of his software are. But don't delay to ask those backup program vendors instantly via email or, even better, in Google+ or Facebook. Whether it is Genie Backup or Recover Lost Photo, just inquire them. Not answering will cost them a client, so they will perhaps have to respond.
Plus remember a simple rule: if there is nothing about a special functionality on a provider site, then it is highly probable there is no such function by the app.
We expect that this Recover Lost Photo review helped you to appreciate the current backup program industry better!
Company: Flash drive data recovery
OS: Win98, WinME, WinNT 3.x, WinNT 4.x, Windows2000, WinXP, Windows2003, Windows Vista Starter, Windows Vista Home Basic, Windows Vista Home Premium, Windows Vista Business, Windows Vista Enterprise, Windows Vista Ultimate


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Given the increasing number of mHealth trials and level of interest in e‐ and mHealth, this is an opportune time to review the available data on the costs and benefits of e‐ and mHealth and suggest a roadmap for future research. This paper is intended to provide an outline of key economic and financial questions to pursue in the development of scenarios for in‐country eHealth policy and strategy investments.
R4D is pleased to present "The Economics of eHealth" paper, authored by Principal, Julian Schweitzer, and Program Associate, Christina Synowiec. The paper, developed in partnership with the United Nations Foundation mHealth Alliance, provides an outline of key economic and financial questions to pursue in informing in-country eHealth policy and strategy investments.
Attached File(s):


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I'm here today because I am gay, and because maybe I can make a difference to help others have an easier and a more hopeful time….I am tired of hiding and I am tired of lying by omission…I suffered for years, My spirit suffered, my mental health suffered and my relationships suffered. And I'm standing here today, with all of you, on the other side of all that pain. — Canadian Actress Ellen Page —
SAN DIEGO, California — Created in the spring of 2015 to ensure equity and advocacy for all students, San Diego Unified School District's new Office of Youth Advocacy recently outlined a long-term strategic plan to address the needs of an ever-increasingly diverse student body across the district.
The plan offers ways to close current achievement gaps and focuses on cultural proficiency; lesbian, gay, bisexual, transgender, questioning (LGBTQ) training and support; restorative practices; ethnic studies; civic collaboration, and substance use prevention.
"Public education has, for decades, tackled some tough issues around equity and around ensuring pathways of success for all students – LGTBQ students, students of color, and those with socio-economic challenges, language barriers or disabilities," said Superintendent Cindy Marten in a press release. "We're making a promise to students to deliver on equity and it's not just our words but our actions that will deliver on this promise."
Marten said the Office has also worked with the district's Safe Schools Task Force as well as other community groups to gather solutions to existing issues.
"We are now ready to expand our implementation of these important and agreed-upon solutions in a systemic, coherent, systematic, focused effort. We will continue to work with our community agencies and partners in supporting our long-term plans," Marten said.
Highlights of the new plan, which will go into effect 2015-16, include: Revisions to the district's anti-bullying awareness policy; annual launch of the Gay, Lesbian & Straight Education (GLSEN) School Climate Survey at all secondary schools; to provide benchmark data for current students; training for all district employees around LGTBQ issues and for compliance with and understanding of Seth's Law, the FAIR Education Act, and the School Success and Opportunity Act, and to assist with providing resources to students including Gay-Straight Alliance (GSA) student clubs and the National Equity Project (NEP); and more.
"We are absolutely committed to providing safe, supportive, and inclusive school environments for all students," said Board President Marne Foster. "I am thrilled and look forward to action plans being implemented for mandatory LGTBQ training for all staff and some of these dramatic things we are doing to support LGTBQ students, including our commitment to having a dedicated staff member focusing on LGTBQ students and improved bullying reporting procedures," said Board Trustee Kevin Beiser.
Article By Gay San Diego Staff – August 21st, 2015
For additional information on the Office of Youth Advocacy, please contact Dr. R. Vernon Moore at firstname.lastname@example.com or 619-260-5433 – (Editor's note: This post was originally published on SDGLN media partner Gay San Diego.)
The New Bullying Prevention © 2015


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Tuesday, November 17, 2015
Koi VII by Natasa Vretenar
In this series, I started the panels with black gesso. I like black gesso because the colours pop out as you layer paint on top of it. Then I used some blue LUKAS paint I had (it is a thick acrylic paint, great for adding texture) to create water ripples. You can see this in the above painting around fish heads the most. Once that layer of paint was sufficiently dry, i continued with glazing and with building the koi texture and transparency. This 12x16" series was a lot of fun to do and I learned a lot by playing with different texture building mediums. I am ready to move on to the larger panels and work on more koi in the near future.
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Sometimes it seems like the coolest part about movies is the anticipation of wanting them to come out.
While I'm not a hardcore spoiler-follower, I do keep up with movie news, productions, and marketing campaigns (or lack thereof). Also, while there are some pretty anticipated films coming out this winter, we're nearing that point where everyone is just waiting for May 2012 to come around. Not only that, but I'm already excited for 2013! That's just how movies work, and it works well.
To help those who don't constantly check movie sites (besides this one, of course), here's an abbreviated list of what's coming out, chronologically, that we're either very excited for or see as major releases. As major news releases, we'll be sure to post it here to keep everyone up to date with what we're keeping our eyes on. Note that while hyperlinks may be provided to spoiler-ish material, none will be shown or revealed in the post beyond casting or production locations and dates.
The Hunger Games (23 March 2012) – I haven't read the novels so I can't say much, but Lionsgate is hoping this franchise can become the next Harry Potter. It's got a pretty solid group of young actors, all of which I admire, with good supporting cast to round everything out. Beyond that, not much has been released besides a somewhat overrated teaser trailer (embedded below), but then if you've read the novel there's not much that needs to be known. There are a lot of young adult series trying to replace Potter right now. I semi-enjoyed Percy Jackson, but it still wasn't able to truly capture people's attentions. We'll see how this one goes, especially since Lionsgate has already green lit the sequel, Catching Fire for 2013.
The Avengers (4 May 2012) – The trailer was just released, so check that out even if you've already seen it. There isn't too much new production news here. They've finished shooting and Joss Whedon is hard at work editing and working through the massive list of visual effects shots. Loki is the villain, everyone is going to be awesome; it's great. At New York Comic-Con, it was "revealed" that Loki will end up fighting each of the Avengers team members in the film at some point. It was also said that Iron Man 3, currently in pre-production with Shane Black directing, will serve as the lead-in to The Avengers 2. In other words, keep planning on seeing Marvel superhero movies for at least the next five years. I'm happy.
The Amazing Spider-Man (3 July 2012) – This is one of those films I'm on the fence about. I like Andrew Garfield and Marc Webb, so it's basically a "wait and see how things turn out." I'm not super excited, but I'll see it in theaters. I mean, it is IMAX 3D on fourth of July weekend. Rhys Ifans is a good actor, but I somewhat side with the skeptics who wander if the seeming mass amounts of CGI will detract from the film. Marc Webb has claimed they did everything on set that they could, and yet the trailer, embedded below, is majority CGI first-person web slinging (which may or may not give people headaches). Plus, we still haven't seen Lizard footage. The film is well into post-production, so hopefully we'll get a new, better trailer attached to one of the winter's releases. Perhaps TinTin, which would work well for seeing the trailer in IMAX 3D. Fingers crossed this isn't a waste of time!
The Dark Knight Rises (20 July 2012) – Whew. There's so much that could be said about this one. First of all, it's going to be awesome. I side with those somewhat disappointed by the teaser trailer attached to Potter, but that's not Nolan's fault – it's Warner Bros. Currently, it seems the only stuff left in production is some scenes in New York, after which it'll enter the long months of editing, visual effects, sound design, and score (go Hans Zimmer!). There have been TONS of set photos leaked about this one, some of which I've seen. We've seen Anne Hathaway in her Catwoman suit, and I don't mean the earless one officially released – but an actual Catwoman suit. We've also seen Bane, Marion Cottilard, and finally enough videos of explosions in the streets of Pittsburgh*cough*Gotham*cough*LA to last us for…well…until the film releases, I suppose. This is one of those films that's just hounded by spoilers, yet at the same time I really want to go into it as fresh as possible because I remember one of the coolest things about The Dark Knight was how much you realized the trailer didn't tell you. Here's hoping we'll get a better, full theatrical trailer attached to a Christmas release, probably Sherlock Holmes: Game of Shadows.
The Hobbit (Part 1, Dec 2012; Part 2, Dec 2013) – Currently deep into its second of three phases of production, things seem to be moving along pretty smoothly after the months of rocky in-between that resulted in Del Toro leaving the project. Still, it's hard to imagine Peter Jackson disappointing. This film is a long ways off, so don't expect a trailer anytime soon. We do, however, have some pretty great production diaries put together by Jackson himself to update us. In addition to this, we've now seen promotional images for pretty much every major cast member, including all of the dwarves. This film should rock, but it's still early in the process to start counting down.
Man of Steel (14 June 2013) – This one is similar to the Hobbit…except not. It's currently deep into production and will remain that way until spring of 2012, though there are probably some breaks included in that schedule. So far, we've seen Henry Cavill officially as Superman as well as leaked set photos of him in suit and Clark Kent clothes (and also shirtless, at some point). We've seen Amy Adams' Lois Lane getup as well as Russell Crowe's Jor-El costume. Basically, all we're missing is a kick-ass teaser trailer to keep us satisfied until 2013 rolls around. My guess is we won't see anything until The Dark Knight Rises, during which we'll probably get an all out IMAX trailer…which will be awesome. Until then, our focus is best put elsewhere.
Bond 23 (unannounced) – News from the next installment in the Daniel Craig Bond series is slow coming, but at least we know the film will happen (which for the longest time was up in the air due to MGM troubles). Sam Mendes (of American Beauty fame, among others) is directing, which automatically gets me even more excited. Craig, Judi Dench are both back along with Javier Bardem and rumored Rhys Ifans (the Lizard in the upcoming The Amazing Spider-Man). It's also known that part of the film will involve major action sequences in South Africa. Beyond that, title and plot are unknown (one newspaper leaked the title Carte Blanche, but EON Productions dismissed the rumor). What we do know is that it's the same team as always brining us another stylish, action-packed Bond film. I'm excited.
Which of these films are you most excited for? Personally, it's The Dark Knight Rises in 2012 and 2013 is tied between Man of Steel and Bond 23 (I'll need a trailer to decide that battle), but man is there so much to look forward to. We'll periodically post updates on these films as major news comes across. Until then, let us know what you're counting down the days to, even if we left it off of the list!


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The first site of its type narrating the history of a phase continuing to be lived in Lebanon, the country of culture, civilization, and history, Mleeta is a terrestrial and sub-terrestrial museum aimed at closely identifying the unique experience of the Islamic resistance in Lebanon against the Israeli enemy from the beginning of the occupation of Lebanon's capitol, Beirut, in 1982.
60 000 m2 of parks and bushy lands, 4500 m2 of built spaces overseen by over 50 architects and engineers and 40 specialists and 90 suppliers all formed an active workgroup from all over Lebanon, continuously overseeing all aspects of the project around the clock for over 2 years.
The site was named Mleeta after the mountain it is situated on, where resistance fighters were stationed throughout the years of the Israeli occupation till the year 2000 when most parts of Lebanon were liberated. Mleeta was one of the first lines of defense in a wide area including Nabatiyeh, Jizzeen, Iqlim al-Tuffah, and was a base for launching various jihadi operations inside the occupied security zone.
Geographic Location
Mleeta Site is located in A'mel Mountain in South Lebanon, some 1050 meters above sea level, surrounded by the villages of Habboush, Jarjou', Mleekh, Al-Luwaiza, Jbaa', and Ain Buswar. Mleeta is also surrounded by mountainous terrains nestling the remains of kings and Prophets of the past. From its elevation, the site overlooks the villages of the Iqlim Al-Tuffah district, Sujud hilltop and part of the shoreline of the Mediterranean Sea.
Mleeta is a naturally beautiful rugged mountainous terrain covered by oak and birch trees and characterized by its rock cavities and natural caves. The mountain spreads over 600 000m2, and excavations have revealed ancient tombs, broken pottery and ancient lanterns.
Mleeta site is 82 km from Beirut, the capitol, 37 km from the city of Saida, and roughly 90 km from the Lebanese-Syrian 'al Masnaa' border point, and 188 km from the borders with occupied Palestine.
Mleeta site can be reached using the following routes:
From Beirut: Beirut >Saida >Zahrani > Zifta > Habboush > Arabsalim > Jarjou >Mleeta 9th optimal route for busses and vehicles)
Or Beirut > Saida > Haret Saida >Kfarhatta >Kfarmilki > Kfarfila > Jbaa' >Ain Bouswaar > Mleeta
From Syria through Masnaa Crossing Point:
MasnaaàShtouraàQib EliasàSughbinàMashgharaàAin el TiniàMaydounàKfarhounaàJizzineàBkasineàJbaaàAin BuswaaràMleeta
General Information
1. Mleeta site opens daily from 10 am to 9 pm
2. Touring the site generally takes between 60 to 120 minutes
3. The site contains panels explaining all scenes and listing all divisions in Arabic and English
4. The Site is run by a specialized team that will insure the safety and comfort of visitors
5. The site has a group of tour guides proficient in English, French, Spanish, Persian, German, and Arabic. Their services are free-of-charge.
Notes for Visitors:
1. Visitors are kindly requested to be appropriately dressed for the site. A hat and sunscreen are advised during summer.
2. Smoking is prohibited, especially in the bushy areas.
3. Strollers are not allowed in the bushy areas due to the rugged terrain.
4. Cleanliness is a must; therefore, rubbish must be discarded adequately.
For More Information: Official Website of Mleeta


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Alexandria's Genesis, also known as Violet Eyes, can be considered a problem which then causes soft epidermis and also purple sight, since the phrase indicates. Individuals will be the greatest manifestations from the dysfunction, but it is alleged that the characteristics on this problem prolong much additional. The article was taken from thehealthinfosite.com
How It's Considered
It is known that the condition is a mutation of the genes, which usually exhibits alone inside the reality that your eye area adjust colour, via azure to be able to purple, inside 1st few months following start. The troubled individuals' eyesight is considered never to become jeopardized, even while the colour of the face expand to some darker tone associated with pink throughout age of puberty.
More features of the disorder presumably include the skin's defense for you to suntanning as well as burning, even with their extra-ordinarily soft hue. Additionally it is said that in addition to the curly hair around the go, the eyelashes, brows, and in the particular nose, not one other body-hair exists upon those suffering from this problem. This would mean that there's no head of hair around the biceps, thighs, torso, as well as genital region. In addition to the areas pointed out, the entire body is devoid of body-hair.
Also, those afflicted with Crimson Eyes (Alexandria's Genesis) are usually centurions, with some speculated to live for the vine ripened later years regarding A hundred and fifty years of age. Growing older halts at about grow older Fifty, and the ones afflicted look no elderly even while these people pass Hundred years of age.
Inter-racial individuals could be suffering from this mutation, yet it's mostly evident together with Caucasians. That they almost never fall ill, and are safe from the majority of ailments. Nor will they gain excessive bodyweight, as well as generate considerably spend it doesn't matter how significantly that they eat. And ladies keep desirable stats during their life-time. Additionally ladies with this particular condition tend not to menstruate, though they're 100% rich.
People who find themselves confident associated with a good Alexandria's Genesis examine your well-known celebrity, Bette Davis, as one prominent individual afflicted with the actual problem. These people refer to your ex violet eyes as evidence for you to substantiate their statements.
To improve their claims, they dispute that you have mutations which steer to the fact that several young children get older in a short time, creating those troubled to have quite quick existence. This is the acknowledged along with established fact, they say as well as, at the same time, there's not any reasons why the opposite can't be correct. Nevertheless there is the recognized mutation which then causes rapid aging as well as a shortened life-span, they will argue, and then it's fairly reasonable to expect a mutation exists with the complete opposite results.
Doubters Differ
Even so, there are other people who vehemently refute this sort of boasts. These people ignore claims the colour of Elizabeth Taylor's eyes has anything at all to do with the presence of the particular problem. They will categorically debate that Violet Face, as well as Alexandria's Genesis, is often a misconception : a metropolitan star * without time frame the truth is.
Skeptics further claim the statements for the people suffering with this problem less difficult also extravagant to get even achievable, not to mention reputable.
For example, that they tell of the reality that no mutation might actually have an effect on that lots of genealogical qualities. Your areas of the body as well as the bodily processes claimed to be affected by this Violet Face mutation, it is said, have been controlled by a few distinct genetics.
They also stage to the fact that fertility, in ladies, without the monthly period, isn't feasible. Despite the fact that there are wildlife which are capable of this specific, it could get even more than a single mutation to be able to adjust your body's genes throughout individuals to experience a real accomplishment.
Additionally, they cite the fact the particular build-up of toxins in the body associated with a human which creates little if any waste could be so high which loss of life is the inevitable result.
In addition, according to the records, skeptics declare, the longest just about any human being has resided is 122 many years. For that reason, accusations that we now have several who may have resided to be able to 150 years of age tend to be misguided.
Skeptics furthermore position that according to our own make-up melanin will be the only method to protect your skin via sun-burn, as an example. Melanin will darken skin, since in the process of tanning : the actual deeper your skin, then this a lot more immune it'll always be to be able to sun-burn. As a result, the notion that you'll find extremely pale-skinned people in living someplace, who will be additionally immune to sun-burn, can be a misconception.
Sources With The LEGEND
Purportedly, in England, inside 1329, a child was created along with lighter epidermis and crimson eyes. Your ex brand ended up being Alexandria, and she or he afterwards delivered two children who each resided effectively past 100 years old.
However, the myth from the Pink Face mutation is considered to get came from around One thousand years ago, inside Egypt. Apparently, the mystical light showed off on the horizon, and all sorts of who were confronted with the idea ended up affected by violet face along with soft epidermis. These people started to be known as spirit people, and finally disappeared.
If the Violet Face mutation is actually reality as well as misconception remains seen. Even so, each of the facts, thus far, seem to point to aforemention


text:
Whitney Houston, Queen Latifah and P Diddy have been celebrated at the BET Honors.
The stars were among five black entertainers recognised for their accomplishments in urban culture at the ceremony hosted by Gabrielle Union and broadcast this week.
According to SOHH, P Diddy, who was honoured for his achievements as a entrepreneur, said in his speech: "I've won a lot of awards before, but I've never been honoured. And being honoured, it feels totally different.
"Especially to be honoured by your people, thank you very much. I'm truly humble, there's a lot of people out there that know my story but there's a lot of people out there that don't. My father was killed when I was three years old so my mother, like millions of black mothers in America, she was a single mother of two raising a family on her own."
Jennifer Hudson, Mary J. Blige and Stevie Wonder also performed at the event, held at the Warner Theatre in Washington DC.


text:
Bath Salts…a pretty sick drug craze that's gripping people around the country. As if the recent "Zombie Apocalypse" due to it wasn't enough, the latest bath salts story to hit the news may actually top that. If the following isn't enough to stop someone from trying bath salts, then I don't know what is. If you haven't heard about this yet, then prepare yourself, because it's disgusting…
See, what had happened was…Police were summoned to the home of 21 year old Matthew Hammond of Gwinnett County, GA for a little disturbance. His mom called them stating that he was "walking around out of his mind,acting in a very schizophrenic manner, and was armed with a knife". When the police arrived, he proved he completely gone and not afraid of them, because he charged at the police car and began banging on the windows. The police were forced to draw down on him, and he was sane enough at that moment to drop the knife. He then challenged the officers to a fight, before being subdued and taken into custody.
When they got him to the police station, they noticed he stunk and he kept quoting the tag line from Frank's Hot Sauce – "I put that shit on everything!". Well, he wasn't lying about that, because upon further inspection, that's exactly what he had in his mouth. No…not Frank's Hot Sauce…shit. Yes, shit! (I'll give you a second to process that image.) They think it was his own shit, but can't really be sure exactly whose it was that was smeared all over the inside of his mouth, his teeth and gum line. I guess that doesn't really matter in the grand scheme of things though. Shit is shit.
Jesus. H. Christ. I really hope that's a gap in his front teeth. OK, I have to be honest, I really don't, because he deserves to have the shit on his teeth on full display in his mug shot! When someone tells this guy his breath smells like shit, they are right on the money! They should take his mug shot and make him the poster boy for a "Just Say No To Bath Salts" campaign. Anything that will make you eat shit, or find other people tasty is perhaps the craziest drug there is.
I'm sure the people who make Frank's Hot Sauce are really thrilled, huh?
**By the way…I know it turns out that the face eating guy in CA didn't have bath salts in his system…but it made for a good headline.


text:
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A veteran police detective becomes a criminal justice teacher and baseball coach at a local high school, leading him to the most important investigation of his life. Inspired by true events.
Movie details The Investigator
Release : 2013-09-20
Genre : Drama
Runtime : 0
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Hey Everyone,
So at Christmas, I was so lucky and grateful to receive the Naked 2 palette and have constantly been using it and trying out all the shades ever since. That is why I thought I would post a review of it today.
My favourite day-time shade is definitely Bootycall. It is the prettiest pink shade ever and goes perfect with my skin tone because I am quite pale. If I have a little extra time to do my make-up that day, I will add a small amount of Chopper on top to give it that extra special look. This is the most stunning shimmery copper shade and would look amazing with any skin tone.
This palette gives you the ability to create the perfect smoky eye in a range of colours. Also there are colours that would look amazing with any skin tone, however I would love for there to be a few more lighter shades and a few more shades that are not so shimmery, so that I could wear them to school and have a more natural look rather than a bolder look.
I hope you all enjoyed this post and may be taking a trip to your local Urban Decay Counter, if you like this sort of post please feel free to tell me in the comments below.
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The team at concealedonline.com really sat up and took notice when this story hit the headlines!
Thousands of officers have been conducting ongoing raids across Europe, netting hundreds of guns, rocket launchers, grenades and tens of thousands of rounds of ammo.
INTERPOL confirms that the sweep was carried out by a huge force of 7,840 police officers across 23 countries.
Doors kicked in, homes turned upside down, weapons seized, lives disrupted!
As reported by the police coalition: "Some 320 firearms – including a rocket launcher and a machine gun – and almost 20,000 pieces of ammunition were recovered, along with grenades and explosives,"
Dubbed operation "Trigger II" this multi-national operation resulted in hundreds of arrests and the confiscation of a vast cache of weapons including rocket launchers and hand grenades.
The authorities go on to say: "More than 10 million checks were conducted against … global databases during the operation, including for wanted persons, stolen and lost travel documents, and stolen motor vehicles."
In Europe, it's unusual for citizens to own a firearm, let alone a rocket launcher or grenade.
In America, on the other hand, this kind of thing would NEVER, EVER happen!
Americans have the right to possess an almost unlimited amount of weaponry (excluding grenades and rocket launchers) thanks to the hard-won protections afforded them by the Second Amendment.
We at concealedonline.com stand shoulder-to-shoulder with our fellow European gun-owners!


text:
[1] Catal, C. and Diri, B. (2009). A systematic review of software fault prediction studies. Expert Systems with Application, 36:7346-7354.Google Scholar
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[3] Hall, T., Beecham, S., Bowes, D., D., G., and Counsell, S. (2012). A systematic review of fault prediction performance in software engineering. IEEE Transactions on Software Engineering, 38:1276-1304.CrossrefWeb of ScienceGoogle Scholar
[4] Jureczko, M. and Madeyski, L. (2010). Towards identifying software project clusters with regard to defect prediction. In Proceedings of the 6th International Conference on Predictive Models in Software Engineering, PROMISE '10, pages 9:1-9:10, New York, NY, USA. ACM.Google Scholar
[5] Khoshgoftaar, T., Allen, E., Hudepohl, J., and Aud, S. (1997). Application of neural networks to software quality modelling of a very large telecommunications system. IEEE Transactions on Neural Networks, 8:902-909.CrossrefGoogle Scholar
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[8] Klas, M., Nakao, H., Elberzhager, F., and Munch, J. (2008). Predicting defect content and quality assurance effectiveness by combining expert judgment and defect data-a case study. Proceedings of the 19th International Symposium on Software Reliability Engineering, pages 17-26.Google Scholar
[9] Li, P., Herbsleb, J., Shaw, M., and Robinson, B. (2006). Experiences and results from initiating field defect prediction and product test prioritization efforts at abb inc. Proceedings of the 28th International Conference on Software Engineering, pages 413-422.Google Scholar
[10] Madeyski, L. and Jureczko, M. (2014). Which Process Metrics Can Significantly Improve Defect Prediction Models? An Empirical Study. Software Quality Journal.Google Scholar
[11] Madeyski, L. and Majchrzak, M. (2012). ImpressiveCode DePress (Defect Prediction for software systems) Extensible Framework. Available as an open source project from GitHub: https://github.com/ImpressiveCode/ic-depress.Google Scholar
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[13] Ostrand, T. and Weyuker, E. (2002). The distribution of faults in a large industrial software system. SIGSOFT Software Engineering Notes, 27:55-64.CrossrefGoogle Scholar
[14] Ostrand, T., Weyuker, E., and Bell, R. (2005). Predicting the location and number of faults in large software systems. IEEE Transactions on Software Engineering, 31:340-355.CrossrefGoogle Scholar
[15] Ostrand, T., Weyuker, E., and Bell, R. (2010). Programmer-based fault prediction. Proceedings of the Sixth International Conference on Predictive Models in Software Engineering, pages 1-10.Google Scholar
[16] Rudiger, L., Lundberg, J., and Lowe, W. (2008). Comparing software metrics tools. Proceedings of The 2008 International Symposium on Software Testing and Analysis, pages 131-142.Google Scholar
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[18] Succi, G., Pedrycz, W., Stefanovic, M., and Miller, J. (2003). Practical assessment of the models for identification of defect-prone classes in object-oriented commercial systems using design metrics. Journal of Systems and Software, 65:1-12.Google Scholar
[19] Tosun, A., Bener, B., Turhan, B., and Menzies, T. (2010). Practical considerations in deploying statistical methods for defect prediction: A case study within the turkish telecommunications industry. Information and Software Technology, 52:1242-1257.CrossrefWeb of ScienceGoogle Scholar
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About the article
Published Online: 2015-03-01
Citation Information: Foundations of Computing and Decision Sciences, Volume 40, Issue 1, Pages 17–33, ISSN (Online) 2300-3405, DOI: https://doi.org/10.1515/fcds-2015-0002.
© 2015 Jarosław Hryszko and Lech Madeyski. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0


text:
- You may wish to consult
Abigailfor other, similarly-named pages.
Abigail Crowe was a conspiracy theorist who hosted a pirate radio show late at night called Dark Talk, discussing extraterrestrial affairs around Cardiff.
The signal for an alien invasion was being broadcast from Dark Talk's radio station. Gwen and Ianto stormed Dark Talk on air. Crowe transformed into her true alien form and took Ianto hostage. It was at this point she tried to activate the invasion signal but the recruit activated a jamming signal and stopped the invasion. Crowe was shot and killed by Gwen. (GAME: Torchwood Mission Game)
Behind the scenes Edit
- Although her radio show is not important in the plot of the game until the last mission, it is recommended to listen to it each mission.


text:
Polybear: Ice Escape v1.4.1 Android Apk Hack Mod Download
Polybear: Ice Escape v1.4.1 Android Apk Hack (Unlocked) Mod Download
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text:
Author: SAIT Technical
Q: A client disposed
of several motor vehicles. The vehicles were thus not trading stock. When I am
completing the ITR14, one question is whether there was there a capital gain or
loss in the financial year. My question is does the disposal of motor vehicles
result in CGT?
A: The base cost of an asset
must be reduced by an allowance claimed (e.g. s11(e) ITA wear& tear) per
para 20(3)(a) Eighth Schedule of the Income Tax Act (ITA). On disposal of the
asset the amount recouped on sale (i.e. exceeds base cost) must be reduced from
base cost unless it was included in income in terms of section 8(4)(a) of the
ITA. The recouped amount will also not form part of proceeds on disposal if
included in income.
For example, a car
purchased for R100, is kept for 2 years and R40 wear& tear claimed (i.e.
base cost is now R100-R40 ito para 20(3)(a)). It is sold for R70 proceeds. A
recoupment of R10 will be included income as an amount recovered of a previous
allowance (i.e. amount in excess of base cost) in terms of section 8(4)(a) of
the ITA. R10 will then also be deducted off the proceeds which makes the
proceeds R60 which is the same as the base cost resulting in no capital gain.
If the car had been sold for R110, then R40 would be a taxable recoupment and
the proceeds would be reduced by R40. Therefore a capital gain of R10 would be
realised (R70 proceeds – R60 base cost).
Disclaimer: Nothing in this query and answer should be construed as
constituting tax advice or a tax opinion. An expert should be consulted for
advice based on the facts and circumstances of each transaction/case. Even
though great care has been taken to ensure the accuracy of the answer, SAIT do
not accept any responsibility for consequences of decisions taken based on this
query and answer. It remains your own responsibility to consult the relevant
primary resources when taking a decision.
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Activators of nitric oxide synthase
Dr Colin Gibson, Dr Paul Coats, Professor Colin Suckling
36 months
Eligibility criteria
2.1 degree in chemistry
The Project
Nitric oxide is a key signalling agent in the body and is generated from arginine by nitric oxide synthase (NOS). One NOS isoform, endothelial NOS (eNOS) is responsible for relaxation of the blood vessels in the body. Various disease states result from a malfunction of this enzyme and we have previously reported the preparation of stable analogues of the NOS coenzyme, tetrahydrobiopterin. These analogues result in the relaxation of eNOS under disease state models and have potential in the treatment of atherosclerosis. Despite current drug therapies (aspirin, ACE inhibitors, beta blockers and statins) there is still an unmet need for further novel drug therapies.
This project will seek to prepare new analogues of oxidatively stable blocked dihydropterins as activators of nitric oxide synthase with potential as treatments of atheroscrelosis. The project is mainly synthetic but will involve collaboration with international experts in the field of NOS to measure various enzyme kinetic parameters. It will also involve collaboration with pharmacologists to establish biological activities of the new synthetic entities.
Light-Activated Approaches to Organic Electron Transfer Reactions
Professor John Murphy, Dr Tell Tuttle
42 months
Eligibility criteria
Candidates with a 1st class or Upper 2nd class degree in Chemistry or equivalent
The project
We have recently developed a family of simple novel organic reducing agents (Super Electron Donors) comprising simply carbon, hydrogen and nitrogen that have record strengths. They can achieve unique and novel transformations that are useful for synthesis, and can also replace transition metal (e.g. palladium) catalysts in key coupling reactions. They become even more powerful when activated by visible light. Now we want to make them catalytic and that is a major focus of this PhD project. This will provide a new direction to photoactivated organocatalysis, targeting reactions that have never been achieved with organic reagents. Our research is undertaken in collaboration with Dr Tell Tuttle.
The project will provide an excellent training both in forefront synthetic organic chemistry and in computational chemistry, which assumes an ever greater importance in the training of synthetic chemists.
J. A. Murphy, J. Org. Chem.2014, 79, 3731-3746. DOI: 10.1021/jo500071u
36 months
To be obtained
1st of upper 2nd class honours degree in Chemistry or equivalent
The project
These days, the creation of new roles for carbon dioxide waste assumes a high priority, so that 'Carbon Dioxide' is on the Grand Challenges posed to chemistry by the Research Council, EPSRC. Nature reduces carbon dioxide:
- by photosynthesis in plants
- by conversion to methane in methanogens.
The project uses synthetic organic chemistry to address a pressing environmental need. Besides equipping the Ph.D. student with experience in environmentally relevant perspective on chemistry, it will provide an excellent training both in forefront synthetic organic chemistry and in computational chemistry, which assumes an ever greater importance in the training of synthetic chemists.
A recent reference: MJ Corrand, JA Murphy, Chem. Soc. Rev. 2011, 40, 2279-2292. DOI:10.1039/C0CS00150C
A new synthetic biological tool in RNA research: expanding nature's genetic repertoire for site-specific incorporation of functional groups in RNA to study alternative RNA splicing
Dr Glenn Burley, Dr Hing Leung
Background - Prostate cancer (PC) is the second commonest cause of cancer deaths in British males with nearly 10,000 deaths per annum. There are 36,000 new cases reported every year and this figure is predicted to double over the next 20 years, placing considerable strain on our healthcare sector. This problem is further exacerbated by the ineffectual androgen deprivation therapy (ADT) currently available for the treatment of locally advanced PC, which inevitably progresses to castrate-resistant prostate cancer (CRPC). Chemotherapy with docetaxol or carbazitaxol only prolongs life in CRPC patients by weeks, thus a platform technology that can selectively deliver therapeutic payloads more effectively to target CRPC tumours is urgently needed.
Project Objective - The principal objective of this studentship is to develop a new platform technology for the efficient delivery of a chemotherapeutic payload to prostate cancer cells. This will involve the synthesis of a trimodal delivery system comprising a targeting group, a cell uptake enhancing module linked to a chemotherapeutic. This is a collaborative Chemical Biology project that will involve extensive interaction between Glenn Burley's synthetic group and Hing Leung's oncology group based at the Beatson Institute for Cancer Research.
Academic Environment - The student undertaking this project will receive unparalleled experience in all aspects of modern chemical biology within our industrially-facing interdisciplinary collaboration. Dr Glenn Burley has extensive experience in small molecule synthesis, solid phase peptide/nucleic acid synthesis and microfluidic device fabrication to culture prostate cancer cells. Cell-based experiments will be conducted n the synthetic biology laboratory of Dr Michele Zagnoni whose group has developed a high-throughput microfluidic platform to analyse cell uptake and cytotoxicity. Tissue and in vivo work will be conducted in the world-leading oncology group of Prof. Hing Leung (Beatson Institute). Prof. Leung has access to state-of-the-art facilities and expertise to assess and quantify the selectivity of cell uptake and the efficiency of the dose and toxicity in castrate-resistant mouse models. In addition, the student will collaborate with Chemical Biology groups based at GlaxoSmithKline's (GSK) Stevenage site.
Funding Notes
This EPSRC Industrial CASE studentship (4 years) is open to Home/EU students. The student will spend at least 3 months in GSK's state of the art laboratories in Stevenage learning cutting edge techniques related to medicinal chemistry and chemical biology.
Candidates should have a strong background in Synthetic Organic or Medicinal Chemistry/Chemical Biology and have obtained a (i) or 2(i) [or equivalent for EU students] degree.
Candidates who are interested in this position are encouraged to send their CV and contact details of two referees to email@example.com before 31st January, 2016.
1. Smith, L.D., Dickinson, R.L, Lucas,C.M., Cousins, A., Malygin, A.A., Weldon, C., Perrett, A.J., Bottrill, A.R., Searle, M.S., Burley, G.A., Eperon, I.C. "A targeted oligonucleotide enhancer of SMN2 exon 7 splicing forms competing quadruplex and protein complexes in functional conditions" Cell Reports, 2014, 9, 193-205 .
2. Fallows, A.J., Singh, I., Dondi, R., Cullis, P.M. Burley, G.A. "Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach" Organic Letters, 2014, 16, 4654-4657.
3. Singh, I., Wendeln, C., Clarke, A.W., Cooper, J.M., Ravoo B.J., Burley, G.A. "Sequence-selective detection of double-stranded DNA sequences using pyrrole-imidazole polyamide microarrays" Journal of the American Chemical Society, 2013, 135, 3449-3457.
4. Rajan, P.; Sudbery, I. M.; Villasevil, M. E. M.; Mui, E.; Fleming, J.; Davis, M.; Ahmad, I.; Edwards, J.; Sansom, O. J.; Sims, D.; Ponting, C. P.; Heger, A.; McMenemin, R. M.; Pedley, I. D.; Leung, H. Y. Next-generation Sequencing of Advanced Prostate Cancer Treated with Androgen-deprivation Therapy. Eur. Urology 2014, 66, 32-39.
5. Ahmad I, Patel R, Singh LB, Nixon C, Seywright M, Barnetson RJ, Brunton V, Muller WJ, Edwards J, Sansom OJ, Leung, H. Y. HER2 overcomes PTEN (loss) induced Senescence to cause Aggressive Prostate Cancer. Proc. Natl. Acad. Sci., 2011, 108, 16392.
Professor Nick TomkinsonOrganocatalytic alkene bis-functionalisation
3 years
Eligibility criteria
EU National or self-funding
The project
A new project recently initiated within the group is concerned with the organocatalytic bis-functionalisation of alkenes, with the ultimate aim of delivering a simple and effective metal-free methods for alkene substitution.
3 years
Eligibility criteria
EU National or self-funding
The project
In a mature collaborative project with Dr. Jamie Platts at Cardiff University we are unraveling the catalytic cycle of secondary amine catalysed activation of carbonyl compounds through a combination of synthetic, structural, mechanistic, and computational approaches, with the ultimate goal of developing the bench-mark catalysts for this important class of reaction.
Professor William KerrEnhanced Homogeneous Iridium Complexes for Widespread Application in Synthetic Organic Procedures
3.5 years
1st or Upper Second MChem/MSci undergraduate degree
Aims of the project
- to refine emerging iridium catalyst systems by the interdisciplinary combination of preparative organometallic chemistry and theoretical chemistry methods, for the wider application of these modified catalyst species in hydrogen-isotope exchange processes;
- to apply the developed catalyst species in mild and selective hydrogenation reactions of direct relevance to the pharmaceutical, agrochemical, and fine chemicals industries; and
- to develop new and strategic applications for the new catalyst systems in a series of novel organic bond forming processes.
3.5 years
Eligibility criteria
1st or Upper Second MChem/MSci undergraduate degree
The aims of the project
- develop and strategically employ catalytic cobalt-mediated cyclisation chemistry to allow synthetic access to the key structural features of the Agariblazeispirol C natural product system
- establish new asymmetric palladium-catalysed methods for the construction of the A-B ring system of Agariblazeispirol C
- synthesise Agariblazeispirol C and prepare a series of medicinally-important analogue systems
3.5 years
1st or Upper Second MChem/MSci undergraduate degree
Aims of the project
- investigate the applicability of novel heteroatom containing substrates such as enol ethers, and other more functionalised derivatives, as alkene partners within the Pauson-Khand annulation process
- develop a general and practically efficient reaction protocol that will deliver a range of pharmaceutically important cyclised scaffolds, with potential sites for further elaboration
- strategically employ the newly developed methodology in the total synthesis of Xeromphalinones C and D and prepare a series of medicinally-important analogue systems
Professor Duncan GrahamSynthesis of functionalised nanoparticles for imaging biological interactions relating to cancer
42 months
Eligibility Criteria
UK national or relevant UK connection plus 2.1 minimum
Funding has been secured for this project
The project
We've recently been able to show that nanoparticles functionalised with a specific lectin which binds to sialic acid on the surface of cells can be used to quantify the numbers of normal cells and cancer tumour cells from a single patients sample.
In this preliminary example we were able to detect prostate cancer cells. The measurement is based on surface enhanced Raman scattering coding from specific nanoparticles which can be functionalised to interact with different cell surface moieties in a quantitative and multiplexed fashion. In order to extend this preliminary data we would propose to investigate the functionalization of metallic nanoparticles with specific receptor systems to bind to lung cancer cells to aid in the diagnosis of lung cancer through a collaborative effort involving scientists in Edinburgh and also Japan.
DDR2 is a protein involved in the signalling pathway for many cancers and the grouping of Professor Kimura at Saga University in Japan have recently discovered a new mutation which appears to be unique to lung cancer populations. This is a very exciting discovery in terms of the potential for both diagnosis and therapy. However there's a bottleneck in terms of being able to identify the cancerous cells containing this mutation. At present, quantitative QPCR methods are required which are time consuming and look at the DNA sequence rather than the proteins actually present. We are looking to develop a new methodology which will report on the effects of this mutation through imaging of the mutated proteins directly using these functionalised nanoparticles. In order to achieve this we are proposing to develop a new monoclonal antibody or peptide aptamer which will bind specifically to these cancer cells. This aspect of the training will be conducted in collaboration with Professor Ted Hupp at the University of Edinburgh.
We've already successfully co-supervised a PhD student and this is a logical expansion of our growing activities. Professor Kimura has sent one of his PhD students to spend 6 months in our laboratory which is seeding this work indicating the collaborations are in place to provide an excellent research training opportunity for the successful student.
The main aim of this project is to create new functional nanoparticles for use in lung cancer cell diagnosis. The specific objectives are:
- identify the appropriate receptor moiety for functionalization of the nanoparticles in relation to the new mutation identified by the group in Japan.
- investigate the specificity of these nanoparticles against different cell types and cancer mutations with a view to providing quantitative and selective analysis.
- investigate the use of this Raman based analysis of lung cancer cells in aiding clinical diagnosis and hence treatment of lung cancer patients.
- create an international collaboration based on this research methodology.
38 Months
Start date
Available to start now
Eligibility Criteria
UK national or relevant UK connection plus 2.1 minimum
The project
Functionalised gold and silver nanoparticles are gaining in use and interest in both the commercial and academic sectors. Their use is based predominantly on their optical brightness and the most obvious use of gold nanoparticles is in home pregnancy testing. As ever, there is room for improvement in the chemistry associated with the linkage and stability of the nanoparticles when functionalised with the targeting species e.g. an antibody. This collaborative, industry supported studentship has been constructed to investigate the opportunities for new linkage chemistry to functionalise gold and silver nanoparticles in a more robust way than is currently possible. We have excellent background expertise on nanoparticle functionalisations through our last 15 years of research and propose to utilise this along with some innovative new ideas to tackle the problem set by our industrial partner. Our first objective is to produce gold nanoparticles that are extraordinary stable. To do this, we will investigate the nature of the bond to the metal surface, the stabilising linkage which forms a stable shell around the nanoparticle and then the outer functionality which can be used for attachment of biologically active molecules. We will also investigate new approaches for the addition of functionality that haven't been used before to broaden the scientific approach. Stability testing will be done in common buffers and also in harder conditions such as strong acids. We have a range of known chemistries available to us for these studies and have also designed some new approaches which would generate IP in the sector if successful. The objectives set out for this studentship are:
- investigate new linkage chemistries onto gold nanoparticles. This will include conventional thiol based linkages but also alternative multi-dentate ligands and lesser used lewis bases. We will also design a series of linkers that go with the actual surface chemistry to provide further stabilisation via hydrophobic interactions, hydrogen bonding or both.
- assess the stability of these functionalised gold nanoparticles. This is critical to the outcome of the project and the conditions and performance criteria will be set and agreed in advance.
- functionalise the nanoparticles with active species and investigate the issue of non-specific adhesion to non-target species. We will use protein based species such as antibodies and engineered fragments which is in line with the end use requirements of these species.
This is an industrially led PhD programme which has been designed around fundamental science with a highly applied aspect. The area is highly topical and opportunities for further funding based on the outcomes from the research are significant.


text:
I just read last night that there is going to be a remake of The Great Gatsby!! Ever since I have been in such a jazz age mood (yeah, its a mood) and I want to break out my copy of The Great Gatsby.
I want this publication!!!!!!!!!!!! A new hunt, now every time I see a used bookstore, I will go in searching for this.
30 day challenge
Day 9 : favorite places to eat
Well my favorite type of food is Italian. Unfortunately Italian restaurants are super expensive so I rarely eat at them, and prefer home cooked Italian over the places I have ate at (especially over Olive Garden. yuck.) soo... my # 1 favorite place to eat is home.
2nd favorite is Chick-fil-A. Best fast food chicken & amazing milkshakes!
3th favorite is Panera. My favorite from there is the tomato soup. & asiago bread.
4th is a tie between Subway & Firehouse.
5th is Chinese, which is really limited to just my love for sweet & sour chicken with white rice. I like most Chinese take out places.
I really want to try more local places, especially since I live in a college town there are a lot of unique restaurants, however I am poor & really do not eat out unless I go home for the weekend.
Have an enchanting evening!
Wednesday, November 17, 2010
Gatsby & Day 9
Posted by katelynn elizabeth at Wednesday, November 17, 2010
1 comment:
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text:
You've seen this place before here, but wanted to share a little matchbox pinhole photo of it too since this one is in color.
The color shift is a bit weird and I couldn't quite get it corrected in PS, so just left it funky.
This is west of Albuquerque on Route 66.....a nice little drive for exploring.
I know I'm not the most regular or scheduled poster here, but I do appreciate your visits!
Hand built pinhole cameras made from found pieces of aged lumber, scraps of vintage wood and a few whimsical tin cans and boxes.
Thursday, August 28, 2014
Matchbox Pinhole
Posted by astrobeck at 10:07 AM
3 comments:
I really like this rendition Becky. I've yet to do a 'small scale' pinhole camera, but this is pretty inspiring. Thanks for sharing.ReplyDelete
I'm liking your recent series of posts a lot. Sorry I haven't commented more often. Keep up the good work.ReplyDelete
hi! Thanks for your visits!ReplyDelete
I'm not so prompt at replying or even posting, but I do appreciate your kindness and time spent here.
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text:
Kevin posted the following in his blog:
"A cento is a poem composed of verses or passages taken from other authors, disposed in a new form or order. So says Wikipedia."
He also posted a cento he'd written. Intrigued, I decided to try writing one as well. Every line is from a different poem; the only exception is: "Is it really you/rising from the script of waves." I just couldn't separate those two lines, so I kept them both. This was fun.
Love is a shadow.
I have been flickering, off, on, off, on.
A Candlemas of moving lights along Route 80;
Glowing like turquoise.
Write this. A word may be shaped like a bed, a basket of tears or an X.
The clear vowels rise like balloons.
Ink runs from the corners of my mouth.
But you were everywhere beside me, masked,
the fission of music into syllabic heat –
enough daubed here and there with a little ink.
Is it really you
Rising from the script of waves?
You take my hand; then we're alone.
Then I am you and you are me.
The sun burns through the walls.
Sunday, April 13, 2008
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text:
Mr. Thangkou Lor
Supervisory Staff
Assist in supervising the Refectory, Computer Lab, Gym and Senior Dorm.
With St. Lawrence Since
September 2013
My Long-term Vision for St. Lawrence Seminary is...
As a staff supervisor, I want Saint Lawrence to be a place of safety and learning for these young men. I want them to continue to grow their minds academically and spiritually so that they may become good leaders, but more so, become good stewards of our Catholic faith. Our values here at Saint Lawrence is to teach these young men about Jesus Christ and prep them for a life after high school. With all the programs going on at Saint Lawrence, I want to foster an environment that is caring, inviting, and wlecoming to studetns.
Education Background
SLS class of 2009


text:
I've seen a lot of posts on here about people suffering terribly with lower back pain caused by bulging discs. I just wanted to share my experience of this therapy. Firstly its not available on the NHS and is very expensive. It is usually , or in my case anyway, performed by my osteopath. Three years ago I herniated a disc at L3 taking my shoes off. It was so painful and I was bedbound for several weeks. Painkillers did nothing, visited a chiropractor who would not touch me because the pan was so severe. In desperation I researched and found out about IDD therapy at my osteopaths. It cost me approx. £1300 for 20 sessions. It's a bit like the old fashioned traction the NHS gave me many years ago but much more sophisticated and linked to a machine that calculates the amount of tension to apply. Its completely painless and I have to say that after the 2nd session I started feeling relief. Now I know everyone can't afford it , in fact I couldn't now as not working, but just thought I would put it out there for people to do their own research. If it helps anyone I'm glad.
Jo x


text:
Connor has become a newspaper reader. For years, we sheltered the children from news - going so far as to never have even NPR playing in the car or home when they were around. When something scary happened in the world, we would wait to discuss it until evening. On the rare occasion that someone came home with information we would've preferred they didn't have, we'd suss out what the child knew, explain it in as simple a term as possible, remind the child they were safe, and we'd pretty much all move on.
Connor is 10. In the past ten years, wars were raging outside our home. Black men were being gunned down by police as if for sport. Coalitions fighting economic injustices were camping outside the White House. The economy collapsed. Housing prices rebounded, at least partially. Children went to school one morning in Newtown and never returned home to their moms. The finish line at the Boston Marathon exploded. The day Connor came home from first grade asking about 9/11 was one of many days my heart broke. What good was this information to a first grader?But in our house, one day was pretty much like the next. Love wins. Treat people kindly. Stop bickering with your sibling. Dinner is served.
But there's a point in life when your child seeks information, and resisting giving it to him will only make it more coveted. And that point has come. We are now subscribers to the Washington Post (I like the NYT better but I figured the local angle in the Post might interest Connor). Connor, in his typical consumer of words mindset, attempts to devour as much of the paper as possible.
It's a real change to have a 10 year old commenting on current events in our house. But I guess I should just celebrate the last 10 years as a victory and get over it. I suspect for the next few years, much of parenting will be learning about how little I'm able to protect my children from the outside world.


text:
Over the last five quarters, the BizCover Small Business Insurance Price Index has shown that despite the "want" of insurers to increase prices, there has been very little movement in SME insurance pricing, with any price increases being mainly observed in the retail sector.
A high-level view of this quarter's index shows that insurers are still trying to increase SME premiums, however they have only achieved a two-point gain over the quarter and no substantial gains in the past three years, which means competition is still winning and prices are staying low. The insurers are talking about price increases, however in practice these increases seem to be lower than expected.
Looking further into the index, Business Packs in the retail sector have risen over 17 points over the last year, where as Business Packs in the Trades and Services sector have seen very little change. The likely reason for this is the increased premiums for property related insurance which is more commonly bought by those businesses with stock.
Another area starting to show price increases is in the new business book, as insurers are more willing to push prices up with new clients, in order to protect their existing book.
There is still an abundance of competition that will generally keep prices low. While across the board price increases are unlikely, insurers may see some relief in three specific segments; property located in areas exposed to catastrophe events, commercial motor and Directors and Officers for listed companies. Other than these three areas we expect the majority of customers to continue to benefit from strong competition.
While the insurers are talking up prices, the changes are minimal and there is no evidence to show that prices will increase across the broader SME sector, instead they will be contained to areas that insurers feel more confident in increasing prices without harming existing business.
Michael Gottlieb, Managing Director, BizCover
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text:
Off and on for several years, I've wanted a road bicycle. Not the hundred-pound monstrosity I bought on ebay fifteen years ago that calls itself a mountain bike. Not even a quality mountain bike.
A road bike. The kind made for asphalt and speed. Never mind that I probably won't ever ride it more than one hundred miles total. If even a tenth of that.
I still want one. It doesn't need to be a fifteen thousand dollar Pinarello, but I damn sure don't want anything made by Huffy. My recent physical struggles with running have rekindled my interest, and if I am going to do it, I require quality.
I think I've found the one – a closeout deal on a non-current model year of the Jamis Xenith Endura Sport. It has a carbon fiber frame and fork, and solidly middle-of-the-road hardware. It retails for $1,800 but can be had for slightly under a grand. All indicators point to it being a good, reliable machine.
I have a lot of other irons in the fire, so to speak, and I probably shouldn't have spent the money. But last night I went ahead and ordered one. It is scheduled to arrive here around the middle of next week. Then I'll take it to a local bike shop for a fitting, after which I'll be ready to ignore it.


text:
You can easily make your niece giggle and squirm by tickling her. But no matter how ticklish you are, you can't tickle yourself. Why not?
What is a tickle?
It's a sensation between an itch and a brush, yet it can often provoke laughter and a pleasant response. It can play a social role. Your niece may merely giggle because of the sensation, but it could also be due to conditioning – tickling might be a learned way for adults and children to bond, for example. Tickling can also be a form of couples-bonding or sexual foreplay – perhaps the laughter and retreat may be a way of showing some level of submission to your partner.
So why can't you tickle yourself?
Part of this may be psychological. If social conventions play a role, you may not react because tickling yourself involves no interaction with another person. This is not the whole story, however as studies have shown that tickling by a perceived machine is as effective as tickling by another person.
So it probably comes down to prior knowledge. When you move your hand, your brain accurately predicts the movement and then attenuates or dampens responses at the expected tickle location.
Experiments using a progressively less controllable robotic arm showed that as the ability to predict the touching sensation is reduced, the tickliness increases. When another person (or machine) tickles you, you cannot predict the motion exactly and thus it feels more tickley.
Blakemore SJ, Wolpert D, Frith C (2000) Why can't you tickle yourself? Neuroreport 11(11):R11-6.
Blakemore SJ, Wolpert DM, Frith CD (1998) Central cancellation of self-produced tickle sensation. Nat Neurosci. 1(7):635-40.
Harris CR, Christenfeld N (1999) Can a machine tickle? Psychon Bull Rev. 6(3):504-10
Selden ST (2004) Tickle J Am Acad Dermatol. 50(1) 93-7


text: What advantage? 16s= heavier than 15. I did it mostly for looks. I do like the tires but if looks are not an issue go with d40, sp8k, or AVS in the 15" size and get the added bonus of more sidewall. I think the d40s are in a little different class than the sp8k or the AVS IMO. But the d40s will last a little longer than the AVS BTDT. Cant speak for the sp8k but I have heard that it wears fairly well and performs as well or better than the AVS. AVS now will do sp8k next.(for experience) 16" now, 16" again (what can I say I like the looks) Pat Martin 864000csq 2 1/2 cat back, H&R-Boge,advanced and loving it. Drilled and stopping it. Koenig Cobra 16x7 with AVS Intermediates, cheap Kelly Springfield snows now, K&N. 95 subaru legacy Bothell, Wa. Item Cost 4-6x15 Ronals $100-$150 4-205-50-15 D40 $412 + shipping $550-$600 or 4-6x16 ? $500-$1000 4-205-45-16 SP8000 $640 + shipping $1150-$1650 Is the advantage of the 16-45 (whether SP or AVS (Pat M?) or whatever) going to be that great over the 15-50 D40? Worth $1000???? I'd love some 5-spoke wheels to match my 5-pot engine, but I also like the stealth of the "stock" Ronal 15s and the chance to spend a grand on a vertical mill or some new springs/struts.