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NON-MAMMALIAN ORGANISMS AS MODELS FOR ANTICANCER DRUG DISCOVERY Release Date: January 10, 2001 PA NUMBER: PA-01-042 National Cancer Institute Letter of Intent Receipt Dates: June 4, 2001 and February 5, 2002 Application Receipt Dates: July 12, 2001 and March 13, 2002 THIS PA USES THE "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. IT INCLUDES DETAILED MODIFICATIONS TO STANDARD APPLICATION INSTRUCTIONS THAT MUST BE USED WHEN PREPARING APPLICATIONS IN RESPONSE TO THIS PA. This Program Announcement replaces PAR-99-019, which was published in the NIH Guide, November 27, 1998. PURPOSE This Program Announcement (PA) encourages the use of non-mammalian organisms to aid in the discovery of new cancer therapies. The use of non-mammalian organisms for the development of new strategies for prevention, early detection, and treatment of cancer is cited in the NCI's 2002 Bypass Budget ( http://plan2002.cancer.gov). The goal of this PA is the identification of key genes and gene products which are altered in human cancer and could be exploited as intervention points or targets for the discovery of new cancer prevention or treatment drugs. Projects could focus on validating inferences already drawn from comparative study of cancerous and normal cells, exploring promising leads from an evaluation of mutations known to be associated with cancer development, or testing hypotheses generated by the identification of new and unknown gene products, such as those sequenced through the NCI's Cancer Genome Anatomy Project (CGAP) (http://www.ncbi.nlm.nih.gov/ncicgap). For example, projects may include development of organisms in which genes in key pathways or processes are mutated or organisms in which human transgenes are expressed to simulate changes known to occur in human cancers. These genetic manipulations could present a "proof of principle" or validation of the importance of the target genes to the development of cancer. Some examples of genes that are well studied in model organisms and known or strongly suspected of involvement in cancer include oncogenes, proto- oncogenes, some cell cycle and signal transduction genes, and DNA repair genes. The use of multiple grant funding mechanisms allows support for a broad range of projects at various stages of development. The exploratory/developmental R21 mechanism supports pilot projects or feasibility studies for new or underdeveloped approaches. Accordingly, a sound rationale and a well designed research plan, but not preliminary data, are required. The R01 supports more advanced projects and collaborative research efforts between experts in non- mammalian biology and investigators with experience in mammalian cancer models for comparative or proof of principle, validation studies. This PA will expire on March 14, 2002, unless reissued. NIH Grants policies apply to these awards. RESEARCH OBJECTIVES The goal of cancer therapy is to eliminate malignant cells while sparing normal cells. Current clinically important drugs act as cytotoxic agents by binding to or damaging DNA, altering cellular processes, or binding to structural proteins such as tubulin causing disruption of cell function. Generally, they were discovered as anti-proliferatives without specific consideration to site of action. Thus, as might be expected, they show significant toxicity to normal cells which limits their clinical usefulness. Targeting specific cell control elements that are altered in tumor cells provides a new and potentially valuable approach to identify new, more selective, and less toxic agents for the cancer armamentarium. By focusing on a specific target or a target operating in a defined pathway, it should be possible to reverse, stop or delay cancer progression. A vast array of altered proteins, regulatory processes, and signaling pathways have been implicated in cancer genesis and progression. However, only a select few, such as ras farnesylation and various protein tyrosine kinases, have been approached for cancer drug discovery. Determining which in this multitude of alterations and mutations are sites of vulnerability and are thus of importance for intervention, as well as designing approaches to exploit these sites for cancer drug discovery, are clearly daunting tasks. Non-mammalian organisms offer an extraordinary opportunity to evaluate the importance and vulnerability of these sites and to suggest which could be of importance for drug discovery. Key regulatory pathways among eukaryotic organisms demonstrate a striking similarity. Importantly, cancer gene homologs and functional pathways containing homologs are of importance in a wide variety of cells including those of non-mammalian origin. Although not always of identical importance in humans, common pathways or at least portions of such pathways could be considered to be "functional cassettes" performing similar tasks within cells or organisms. For this reason, the use of non- mammalian organisms, which are easier to manipulate genetically, has been valuable in defining new pathways relevant to neoplasia as well as functional relationships among the various pathways. For example, at least 100 genes have been identified in yeast which have been classified as "damage control elements" whose gene products are involved in functions such as DNA repair, cell cycle regulation, and spindle formation. Several have been shown to have homologs in human cells such as the MSH2 and MLH1 repair genes and the ATM (ataxia-telangiectasia) cancer susceptibility gene. Likewise, C. elegans biology has defined several genes important to apoptotic pathways with clear homologs in humans. Drosophila have recently highlighted the importance of the sonic-hedgehog pathway, whose members include a gene inactivated in basal cell carcinoma. Xenopus and zebrafish are additional non-mammalian organisms whose biology is being actively studied and are known to contain homologs of cancer relevant proteins. Importantly, genomic sequences of non-mammalian organisms are known as in the case of yeast or are being determined at a rapid pace, thus providing a valuable asset for delineating the complexities of signaling pathways and control functions. Applications without a strong rationale for cancer relevance would not be responsive to this PA. MECHANISM OF SUPPORT Support of this program will be through the National Institutes of Health (NIH) research project grant (R01) mechanism and the exploratory/developmental grant (R21) mechanisms. Applicants will be responsible for the planning, direction, and execution of the proposed project. All PHS and NIH grants policies will apply to applications received and awards made in response to this PA. Applicants for the R21 grant mechanism may request up to $100,000 direct costs (four budget modules) per year unless the application includes consortium costs, in which case the limit is $125,000 direct costs (five budget modules) per year. Support may not exceed two years. Though the size of award may vary with the scope of research proposed, it is expected that R21 applications will stay within the budgetary guidelines for an exploratory/developmental project. The R21 grants are non-renewable, and competitive continuation of projects developed under this program will be through the R01 research grant mechanism. Applications for the R01 grant mechanism may not exceed five years. Collaborative arrangements involving more than one institution are encouraged, including participation of the pharmaceutical industry where appropriate. Specific application instructions have been modified to reflect "MODULAR GRANT' and "JUST- IN-TIME" streamlining efforts being examined by the NIH. Complete and detailed instructions and information on Modular Grant applications can be found at https://grants.nih.gov/grants/funding/modular/modular.htm ELIGIBILITY REQUIREMENTS Applications may be submitted by foreign and domestic, for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Racial/ethnic minority individuals, women, and persons with disabilities are encouraged to apply as Principal Investigators. INQUIRIES Inquiries are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: George S. Johnson, Ph.D. Division of Cancer Treatment and Diagnosis National Cancer Institute Executive Plaza North, Room 8153 6130 Executive Boulevard Bethesda, MD 20892-7456 Rockville, MD 20852 (for express/courier service) Telephone: (301) 496-8783 FAX: (301) 402-5200 Email: email@example.com Direct inquiries regarding fiscal matters to: Jane Paull National Cancer Institute Executive Plaza South, Room 243 6120 Executive Boulevard Bethesda, MD 20892 Rockville, MD 20852 (for express/courier service) Telephone: (301) 846-1013 FAX: (301) 846-5720 Email: email@example.com Direct inquiries regarding review issues to: Ms. Toby Friedberg Referral Officer Division of Extramural Activities National Cancer Institute 6116 Executive Boulevard, Room 8109, MSC 8329 Bethesda, MD 20892-8329 Rockville, MD 20852 (for express/courier service) Telephone (301) 496-3428 Fax: (301) 402-0275 Email: email@example.com LETTER OF INTENT Prospective applicants are asked to submit, by the dates listed on the first page of this PA, a letter of intent that includes a descriptive title of the proposed research, the name, address, and telephone numbers of the Principal Investigator, the identities of other key personnel and participating institutions, and the number and title of the PA in response to which the application may be submitted. Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows NCI staff to estimate the potential review workload and plan the review. The letter of intent is to be sent to the program staff listed under INQUIRIES by the letter of intent receipt date listed in the heading of this PA. APPLICATION PROCEDURES The modular grant concept establishes specific modules in which direct costs may be requested as well as a maximum level for requested budgets. Only limited budgetary information is required under this approach. The just-in- time concept allows applicants to submit certain information only when there is a possibility for an award. It is anticipated that these changes will reduce the administrative burden for the applicants, reviewers, and Institute staff. The research grant application form PHS 398 (rev. 4/98) is to be used in applying for these grants, with the modifications noted below. Application kits are available at most institutional offices of sponsored research and may be obtained from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/710-0267, e-mail: email@example.com. The title and number of this PA must be typed in line 2 on the face page of the application form and the YES box must be marked. For applicants with internet access, the 398 kit may be found at: https://grants.nih.gov/grants/forms.htm. Applicants are strongly encouraged to call Dr. George S. Johnson, as listed in INQUIRIES, with any questions regarding adherence to the guidelines of their proposed project to the goals of this PA. SPECIFIC INSTRUCTION FOR MODULAR GRANT APPLICATIONS BUDGET INSTRUCTIONS Modular Grant applications will request direct costs in $25,000 modules, up to a total direct cost request of $250,000 per year for R01 and, up to a total direct cost request of $100,000 per year ($125,000 if there are consortium/contractual Cost) for R21. (Applications that request more than $250,000 direct costs for an R01 in any year must follow the traditional PHS 398 application instructions.) The total direct costs must be requested in accordance with the program guidelines and the modifications made to the standard PHS 398 application instructions described below: o FACE PAGE: Items 7a and 7b should be completed, indicating Direct Costs (in $25,000 increments) and Total Costs [Modular Total Direct plus Facilities and Administrative (F&A) costs] for the initial budget period. Items 8a and 8b should be completed indicating the Direct and Total Costs for the entire proposed period of support. o DETAILED BUDGET FOR THE INITIAL BUDGET PERIOD - Do not complete Form Page 4 of the PHS 398. It is not required and will not be accepted with the application. o BUDGET FOR THE ENTIRE PROPOSED PERIOD OF SUPPORT - Do not complete the categorical budget table on Form Page 5 of the PHS 398. It is not required and will not be accepted with the application. o NARRATIVE BUDGET JUSTIFICATION - Prepare a Modular Grant Budget Narrative page (see https://grants.nih.gov/grants/funding/modular/modular.htm for sample pages). At the top of the page, enter the total direct costs requested for each year. This is not a form page. o Under personnel, list all project personnel, including their names, percent of effort, and roles on the project. No individual salary information should be provided. However, the applicant should use the NIH appropriation language salary cap and the NIH policy for graduate student compensation in developing the budget request. o For Consortium/Contractual costs, provide an estimate of total costs (direct plus facilities and administrative) for each year, each rounded to the nearest $1,000. List the individuals/organizations with whom consortium or contractual arrangements have been made, the percent effort of all personnel, and the role on the project. Indicate whether the collaborating institution is domestic or foreign. The total cost for a consortium/contractual arrangement is included in the overall requested modular direct cost amount. Include the Letter of Intent to establish a consortium. o Provide an additional narrative budget justification if there is a change in the number of modules requested from year to year. o BIOGRAPHICAL SKETCH - The Biographical Sketch provides information used by reviewers in the assessment of each individual's qualifications for a specific role in the proposed project, as well as to evaluate the overall qualifications of the research team. A biographical sketch is required for all key personnel, following the instructions below. No more than three pages may be used for each person. A sample biographical sketch may be viewed at: https://grants.nih.gov/grants/funding/modular/modular.htm. - Complete the educational block at the top of the form page; - List position(s) and any honors; - Provide information, including overall goals and responsibilities, on research projects ongoing or completed during the last three years; - List selected peer-reviewed publications, with full citations. o CHECKLIST - This page should be completed and submitted with the application. If the F&A rate agreement has been established, indicate the type of agreement and the date. All appropriate exclusions must be applied in the calculation of the F&A costs for the initial budget period and all future budget years. The applicant should provide the name and phone number of the individual to contact concerning fiscal and administrative issues if additional information is necessary following the initial review. Applications not conforming to these guidelines will be considered unresponsive to this PA and will be returned without further review. Submit a signed, typewritten original of the application, including the checklist, and three signed, exact, single-sided photocopies, in one package to: Center for Scientific Review National Institutes of Health 6701 Rockledge Drive Room 1040 - MSC 7710 Bethesda, MD 20892-7710 Bethesda, MD 20817 (for express/courier service) To ensure that the application is received in sufficient time for the review, send two additional copies to: Ms. Toby Friedberg Referral Officer National Cancer Institute 6116 Executive Boulevard, Room 8109, MSC 8329 Bethesda, MD 20892-8329 Rockville, MD 20852 (for overnight/courier service) Telephone: (301) 496-3428 FAX: (301) 402-0275 Email: firstname.lastname@example.com Applications must be received by the receipt dates listed at the top of the first page of this PA. The CSR will not accept any application in response to this PA that is essentially the same as one currently pending initial review unless the applicant withdraws the pending application. The CSR will not accept any application that is essentially the same as one already reviewed. This does not preclude the submission of a substantial revision of an application already reviewed, but such application must include an introduction addressing the previous critique. REVIEW CONSIDERATIONS Applications will be reviewed for completeness by the Center for Scientific Review and for adherence to the guidelines to this PA by the National Cancer Institute. Incomplete applications will be returned to the applicant without further consideration. Applications that are complete and adhere to the guidelines of this PA will be evaluated for scientific and technical merit by a special emphasis panel convened by the Division of Extramural Activities of the National Cancer Institute in accordance with the standard NIH peer review procedures. As part of the initial merit review, all applications will receive a written critique, and may undergo a process in which only those applications deemed to have the highest scientific merit, generally the top half of applications under review, will be discussed, assigned a priority score, and receive a second-level review by the National Cancer Advisory Board. Review Criteria: The five criteria to be used in the evaluation of grant applications are listed below. The goals of NIH-supported research are to advance our understanding of biological systems, improve the control of disease, and enhance health. Within this framework the purpose of this PA is the identification of new approaches for cancer discovery through exploitation of unique features of non-mammalian organisms. Meritorious projects would include those which identify a novel regulatory process in the non-mammalian organism which has high relevance to human cancer. The reviewers will comment on the following aspects of the application in their written critiques in order to judge the likelihood that the proposed research will have a substantial impact on the pursuit of these goals. Each of these criteria will be addressed and considered by the reviewers in assigning the overall score, weighting them as appropriate for each application. Note that the application does not need to be strong in all categories to be judged likely to have a major scientific impact and thus deserve a high priority score. For example, an investigator may propose to carry out important work that by its nature is not innovative but is essential to move a field forward. 1. Significance. Does this study address an important problem? If the aims of the application are achieved, how will scientific knowledge be advanced? What will be the effect of these studies on the concepts or methods that drive this field? 2. Approach. Are the conceptual framework, design, methods, and analyses adequately developed, well-integrated, and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternative tactics? 3. Innovation. Does the project employ novel concepts, approaches or method? Are the aims original and innovative? Does the project challenge existing paradigms or develop new methodologies or technologies? 4. Investigator. Is the investigator appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience level of the Principal Investigator and other researchers (if any)? 5. Environment. Does the scientific environment in which the work will be done contribute to the probability of success? Do the proposed experiments take advantage of unique features of the scientific environment or employ useful collaborative arrangements? Is there evidence of institutional support? The initial review group will also examine: the appropriateness of proposed project budget and duration; the adequacy of plans to include both genders and minorities and their subgroups and children as appropriate for the scientific goals of the research and plans for the recruitment and retention of subjects; the provisions for the protection of human and animal subjects; the safety of the research environment; and conformance with the NIH Guidelines for the Inclusion of Women and Minorities as subjects in Clinical Research. AWARD CRITERIA Applications will compete for available funds with all other approved applications. The following will be considered in making funding decisions: Quality of the proposed project as determined by peer review, availability of funds, and program priority. INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their sub-populations must be included in all NIH-supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification are provided indicating that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing research involving human subjects should read the UPDATED "NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical Research," published in the NIH Guide for Grants and Contracts on August 2, 2000 (https://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-048.html), a complete copy of the updated Guidelines is available at https://grants.nih.gov/grants/funding/women_min/guidelines_update.htm. The revisions relate to NIH defined Phase III clinical trials and require: a) all applications or proposals and/or protocols to provide a description of plans to conduct analyses, as appropriate, to address differences by sex/gender and/or racial/ethnic groups, including subgroups if applicable; and b) all investigators to report accrual, and to conduct and report analyses, as appropriate, by sex/gender and/or racial/ethnic group differences. INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS. It is the policy of NIH that children (i.e., individuals under the age of 21) must be included in all human subjects research, conducted or supported by the NIH, unless there are clear and compelling scientific and ethical reasons not to include them. This policy applies to all initial (Type 1) applications submitted for receipt dates after October 1, 1998. All investigators proposing research involving human subjects should read the "NIH Policy and Guidelines on the Inclusion of Children as Participants in Research Involving Human Subjects" that was published in the NIH Guide for Grants and Contracts, March 6, 1998, and is available at the following URL address: https://grants.nih.gov/grants/guide/notice-files/not98-024.html. Investigators also may obtain copies of the policy from the program staff listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policy. REQUIRED EDUCATION IN THE PROTECTION OF HUMAN RESEARCH PARTICIPANTS Effective October 1, 2000, the NIH requires education on the protection of human research participants for all investigators submitting NIH application for grants or proposals for contracts or receiving new or non-competing awards for research involving human subjects. All investigators proposing research involving human subjects should read the above-referenced policy that was published in the NIH Guide for Grants an Contracts, June 5, 2000 (Revised August 25, 2000), and is available at the following URL address https://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html. URLS IN NIH GRANT APPLICATIONS OR APPENDICES All applications and proposals for NIH funding must be self-contained within specified page limitations. Unless otherwise specified in an NIH solicitation, internet addresses (URLs) should not be used to provide information necessary to the review because reviewers are under no obligation to view the Internet sites. Reviewers are cautioned that their anonymity may be compromised when they directly access an Internet site. HEALTHY PEOPLE 2010 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS led national activity for setting priority areas. This PA, "Non-mammalian Organisms as Models for Anticancer Drug Discovery", is related to the priority area of cancer. Potential applicants may obtain a copy of "Healthy People 2010" at http://www.health.gov/healthypeople/. AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.395, Cancer Treatment Research. Awards are made under authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and administered under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care, or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
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Overwatch is one of the most hyped games I've seen in a while. Every outlet, which reviews video games is giving this one perfect scores. I must admit, I too am taken by the art style, characters and animated shorts that make up the Overwatch "Universe", but the game is far from perfect! While I normally do review video games on this blog, this heavily super-hero inspired game, definitely, is in my wheelhouse!
I like, like everyone, was introduced to the concept of Overwatch with their first animated teaser, featuring characters Tracer and Winston battling Reaper and Widowmaker in a museum. Upon seeing this trailer, I was hooked: I wanted the comic, movie, action figures, Heroclix, and animated series right then! It would take about a year for more animated shorts to come out and Blizzard, the company which created the game/IP, also created 6 digital comics, which you can read and download, for free, from their website. The link to watch or read is here.
In May of the year, the game was released and it was..is a smash success! As I previously stated, every gaming outlet is reviewing the game as perfect or near perfect, which it is far from. Now to be honest, competitive first-person shooters aren't my… "thing"! I've never excelled at them! I also don't play MOBAs or MMOs, so forcing me to group up with strangers is also something I'm not used to, and while I know a huge demographic love this style of game play, I find it very repetitive and very boring! I love these characters and want to learn more about them and their world, but I don't enjoy the game, and that's my issue…there is no story in Overwatch! You learn nothing about the world or the characters in all the time you waste leveling up to earn useless, random loot. On top of that, this game is a "full priced" release on the consoles, at $60, and slightly cheaper on PC, at $40, provided you go for the base edition, WITH MICRO TRANSACTIONS! That is insulting! If you're going to make me pay for the game, then give me everything up front. If this game was free to play, I wouldn't complain about the very slow leveling and random loot drops, because that's the price I pay for playing for free. Also, would it have killed them to add couch co-op, or a special couch co-op mode for the console versions. I want to play with my ACTUAL friends! I can deal with no couch co-op, but what really bothers me is no story campaign mode. This is 2016 and we can't even get a solo campaign, which tells you the story and teaches you about each of the characters. Injustice: Gods Among Us has a fantastic story mode and it's a fighting game…yes, A FIGHTING GAME!
All-in-all, this title is far from perfect! Everyone gave Star Wars Battlefront hell for not having a story mode and being too repetitive, but because it's Blizzard, who only release games when the planets align, they get a pass. Because Blizzard puts time… quality time in their animated shorts, comics, art and characters, we can forgive a few missing modes and micro transactions…NO, ABSOLUTELY NOT! I love Blizzard as much as the next video game fan. While I'm not into Starcraft or World of Warcraft, I do love the Diablo series and in particular, Diablo 3, and I see how much is in that game and it makes me wonder, if Overwatch should have been delayed a bit longer to flesh out it's offerings and make it a complete, "full priced" game! Right now, for me, it's not Overwatch…it's Overhype!

subset: commoncrawl


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Places men and women can connect socially include bars, college campuses, churches, music events and the Internet. Some more creative ideas for places to meet the opposite sex include comedy classes, science-fiction conventions, car shows and blood drives.
When searching to connect with men or women in hopes of forming a long-term relationship, it is most effective to try meeting people during the daytime at places such as church functions and educational settings, reports Psychology Today. These settings make it easy to strike up a conversation about shared intellectual pursuits or spiritual views. Meanwhile, people looking for shorter-term relationships may have more success meeting people in night life settings, such as bars and nightclubs.
People who are tired of the standard ways to connect socially can try attending science-fiction conventions. These events invite people to connect with others over geeky interests in a nonjudgmental atmosphere, which can make for some unique and memorable conversation. Another option people often don't consider is looking for dates at blood drives or other charity events. Men and women who donate their time and resources to charities they support typically have an altruistic side, which many people see as a desirable trait in a partner.


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Home | OziCE Home | Getting Started | Using Maps in CE | GPS/PND/PDA FAQ | Features | Screen Shots | Support |
|Last Updated June 2017
|"Course Up" map rotation 3D perspective view
Gps Requirements
Map Requirements
Vector Maps
OziExplorerCE does not support any vector map formats.
OziExplorerCE Version 2.44a - This download is for new installations, upgrades and evaluation before purchase.
If you are upgrading from a previous version please read "History of Changes" (link below)
This is a trial / evaluation version with restrictions until purchased
This is what you need
Any issues found with program operation please report them to firstname.lastname@example.com
GPS Navigator Type
File to Download
To Install - download the file and run it to install. Installation Notes
|GPS / Navigators running
Windows CE OS 4, 5 and 6
There are many Chinese made Navigators available on eBay and other places which can run OziExplorerCE.
If you have a device which uses a x86 or mips CPU (very rare) please contact us for a special download link.
This is the download that is most likely needed to run OziExplorerCE on a Navigator. We refer to these as a wince core arm device.
|The GPS / Navigators which
use the WinCE "Core" OS may be devices which are dedicated to particular
tasks such as running specific navigation software.
1. Download the file and manually copy it to the device or Memory card using windows explorer.
2. Configure your navigator to run the program - most Chinese Navigators have the ability in their setup to specify which program is run when the GPS Software option is clicked.
Funtrek / Endura
|Holux Funtrek 130 / 132
Lowrance Endura
If you have one of these devices there are special versions of OziExplorerCE to support the special features these devices have.
|Device specific versions
Windows Mobile and Pocket PC
|Windows Mobile 5, 6 and 6.5 Pocket PC's.
Pocket PC 2003
Pocket PC 2000 and Pocket PC 2002
These devices are no longer manufactured but OziExplorerCE will run on the older devices.
|Device specific versions
|The "Windows Mobile Classic" (Pocket PC) and "Professional" (Pocket PC with Phone) Operating System versions are supported. The "Windows Mobile Standard" version (for small non-touch screen phones) is not supported.
OziExplorerCE Screen Designer
The Screen Designer can be used by the user to design or modify the screens displayed by OziExplorerCE
One of the features of OziExplorerCE is the ability to display many different screens by paging through them, these screens can be designed on the PC by use the "OziExplorerCE Screen Designer" program.
OziExplorerCE allows the commands performed by the hardware buttons (Pocket PC's only) and OziExplorerCE Screen Control buttons to be configured by the user. This is done by the Screen Designer program which runs on a PC.
Download OziExplorerCE Screen Designer (version 2.36) - works with OziExplorerCE version 2.42 and above.
Click here to view a YouTube video of OziExplorerCE in use. In the video the OziExplorerCE screens/pages have been designed using the OziExplorerCE Screen Designer.
Purchase OziExplorerCE
OziExplorerCE can be purchased using the Buy Now option on the left hand menu of the web page.
These are the limitations of the Trial / Evaluation version.
Other than for the restrictions mentioned above, the evaluation version works exactly the same as the purchased version.
OziExplorerCE Help
German - German help files for PDA (for version 1.11.4) or Help File (.chm) (some pages still in English)
hits since October 2001


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Need more cute in your life? A kitten adoption shop will "pop up" for two days at the Scottsdale Quarter shopping center.
Adopting a "pop-up" retail approach used successfully to bring fashion, food and art to new audiences, the Arizona Animal Welfare League (AAWL) will have its kitten adoption shop open on July 9 and 10 at the upscale retail center located at 15059 N. Scottsdale Road. AAWL operates the state's oldest and largest no-kill shelter and nonprofit resource for pet owners.
The Kitten Pop Up Shop will be located on South Street across from Grimaldi's Pizzeria, and will be open from 11 a.m. to 4 p.m. each day. The adoption fee is $100 for two kittens.
All kittens have had veterinary exams, and are neutered, microchipped and vaccinated.
The mission of the Arizona Animal Welfare League & SPCA is to end the unnecessary euthanasia of dogs and cats in our community. Founded in 1971, AAWL & SPCA operates the state's oldest and largest no-kill shelter, as well as the most comprehensive humane education program in the Valley, with classes for adults and children's camps, and a clinic providing low-cost veterinary services at its central Phoenix campus.
No federal or state funding is received and all revenue is from private donations and fundraising efforts.
To find out more, go to www.aawl.org or call 602-273-6852.
The Scottsdale Independent is published monthly and mailed to 75,000 homes and businesses in Scottsdale.


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Katy Perry mocks her marriage to Russell Brand
Katy Perry has described her 14-month marriage to Russell Brand as a "very tiny elephant".
Katy Perry has described her marriage to Russell Brand as a "very tiny elephant".
The 'Firework' hitmaker – who split from the British comic in December 2011, just 14 months after they tied the knot – also described the union as "tchotchke", a Yiddish word which means "small bauble or trifle with connotations of worthlessness or disposability and tackiness".
Asked about her marriage at the ASCAP 'I Create Music' Expo in Hollywood last week, she said: "It's a very tiny elephant. It's like a little tchotchke now. The Big D – you can say it."
Katy – who recently split from musician John Mayer – is excited about working on her third album, but admits she finds writing with her regular collaborators Bonnie McKee, Dr. Luke, Max Martin and Greg Kurstin can be like "emotional abuse".
She said: "It's like the dream team. They push me the most, and also argue the most. It's an emotional abuse session."
And the brunette beauty regards herself as a "student of life" as she is constantly searching for new sources of lyrical material.
She explained: "I'm a student of life. Words are like little treasures. I put all of my ideas in a folder, whether I read them in newspaper or through a conversation with friends. I've got years of titles and things I want to write about."
Last month, Russell spoke out about his marriage, poking fun at the elephants they rode at the ceremony in India.
He said: "It was a drag, man. Let me tell you a thing about marriage: Marriage is a bond that can last up to 14 months. This is a sacred 14-month arrangement – begins on an elephant, ends in a newspaper."


text:
|Gold Brocade Jacket Christian Dior | Quilted Bag, Black Pants, Earring and Rings Forever 21 | Gold Peep-Toe Ruffle Flats Steve Madden
I am going to stop attempting taking my photo on Wednesdays nights when I have class. 1) It is getting darker earlier and I like taking my photos outside (which will be problematic once it starts raining) and 2) I utilize time before class to finish homework and cram before a quiz/exam. Being a student while working full-time is actually kind of hard.
That being said, I wanted to share Thursdays outfit since it seems worth sharing because of the amazing jacket. I generally prefer Crossroads Trading Co. over Buffalo Exchange, but in this case I make an exception. During my Las Vegas trip in July, I found this amazing gold brocade jacket by Christian Dior at a Buffalo Exchange in Las Vegas. I went thrifting looking for something that sparkled, and I was not disappointed.
My look is kind of edgy today, perfect for going out for some cocktails after a long day at work. (And it was long since I worked an extra hour and deserved the cocktails I had with some coworkers!) I would have loved to wear this 40's-inspired jacket with heels, but the flats matched the gold on the jacket perfectly (especially with the little ruffles looking like the roses!) I got a couple of mix reviews from co-workers, but the general consensus was that the jacket looked good on me. (yay!)
What would you wear with this jacket?


text:
We were discussing the differences between having a branch in Brazil or incorporation a new company, owned and controlled by a foreign entity.
- What is the procedure to create a branch. What has changed lately?
- How much time does the special approval take (on top of the usual time for incorporation of a new company)?
- How could a new company be controlled by a foreign investor?
- Is there any down side of using a subsidiary (new company) instead of a branch?
- Would it be legal for the investing company abroad and the new company in Brazil to conduct transactions and have financial ties?
- How long does it take to open a new company?


text:
Ford Motor Company and John Deere Corporation, supported by research funded by the United Soybean Board, are moving forward in replacing even a larger percentage of petroleum-based products, specifically the foam used in seats, head and hand rests, with more soy-based products.
Today, at the Commodity Classic conference, Matthew Zaluzec, manager of Ford's Materials and Research and Advanced Engineering Department, announced that Ford is committed to producing soy-based cushioning, displacing 40% of its former petroleum-based products with polyol derived from soy oil.
Earlier this year Ford launched the new products using 5% soy-derived materials in its Ford Mustang, F-150, Expedition and Lincoln Navigator. It will expand the line to include the Ford Escape in 2009 and two other vehicle lines, yet to be announced, that year. It will also increase the formulation to 40% in the near future and is currently researching ways to incorporate soy-based products, including the meal, in rubber formulations for floor mats, cup holders and bed mats.
The research, conducted in Dearborn, Michigan, is partially funded through grants over the last three years from USB.
John Deere, in collaboration with Ford, is using the technology to manufacture soy-based flexible foam for seating materials in tractors, riding mowers and other equipment.
"We have the ability to have a significant impact on the environment without compromising the durability, stiffness or performance of the foam," Zaluzec says. "When crude oil was $40 a barrel, there were few interested in developing this product. But now that oil is more than $100 a barrel, everyone is interested. Even before the economics came into play, we recognized the need, and the desire of consumers, to have greener materials to displace petroleum. We are happy to be at the forefront of being able to offer this product without costing the consumer anything, while chipping away at our dependence on the petroleum industry. We've made not just a promise, but a commitment."
Don Borgman, director of ag relations at John Deere, adds, "This is another step in weaning ourselves of foreign oil and are expanding that commitment with soy-based body panels and hoods on farm equipment."
Zaluzec says that $60 a barrel oil is the cross over, or the cost-neutral, base for switching to soy-based products. "Today, this not only makes environmental sense, it has financial incentive," he says. "We have developed a 5% replacement, and through research, we are now at 40%. There is great potential and some didn't believe it was possible."
By working with the Lear Corporation, that technology has gone from an experimental level to being fully commercial
According to Zaluzec, by Ford using 5% soy-based products in the 2008 Mustang along, it has utilized 850,000 bushels of soybeans. "Imagine what the potential is with using 40% and expanding it to all Ford vehicles," he says.
Human use of soybean oil will continue to be its primary use, according to Chuck Myers, vice chair of the USB. "But this is a great new use of soybeans for expanding renewable resources. Consumers want to see that and I'm convinced that if we develop more demand, growers will respond by producing more. "I'm not concerned with playing food uses against industrial uses. Farmers are quick to respond to demand. This is an excellent leverage of check-off dollars to create new uses for soybeans."


text:
Viewing entries posted in June 2015
Newsletter 158
2 Chronicles 6:14
O LORD, God of Israel, there is no God like you in all of heaven and earth. You keep your covenant and show unfailing love to all who walk before you in wholehearted devotion.
Newsletter 157
Psalm 139:1-3
O Lord, you have searched me and known me!
You know when I sit down and when I rise up;
you discern my thoughts from afar.
You search out my path and my lying down
and are acquainted with all my ways.


text:
Home Health Care in Fulton, NY can be categorized as either non-medical (home care) or Medicare certified (home health). Non-medical home care includes personal care and help with everyday activities, while Medicare certified home health involves skilled nursing and rehabilitation. Elderly residents of Fulton, NY may require home health after an injury or illness, whereas non-medical home care is provided long-term to seniors with declining physical and mental abilities. This directory includes agencies near Fulton, NY and the surrounding areas. It's not uncommon for agencies to cover multiple counties. Pay close attention to minimum hours and affiliations / recognitions. Call to compare rates and keep in mind that the average cost of a home health aide in Fulton, NY is $23 per hour (according to John Hancock's 2016 Cost of Care Survey). Finally, contact your local Area Agency on Aging to ask about family caregiver respite and senior transportation services.
TrueCare24 provides reliable and affordable caregivers starting from 1 hour, one time visit to 24/7 live-in care. ...
Home Instead Senior Care has been serving seniors and their loved ones since 1994. Recognizing the value of aging in place, they offer a broad range of services that can be tailored...
Interim HealthCare is the nation's oldest health care franchise company. They offer a variety of home care services for people of all ages, from infants to the elderly. Interim's mission,...
Comfort Keepers ® The Heart of Comforting In-Home Care Nothing is more important than helping people to live independent and dignified lives within the comfort of their own homes....
Providing in home care to our community for over 20 years as a Licensed Home Care Agency. AmeriCare provides personal care and homemaking services to individuals in there home....
113 schuyler street, suite 3
fulton, NY 13069
Provider Number: 337284
Medicare Certified: 1991
200 elwood davis road, 2nd floor
liverpool, NY 13088
Provider Number: 337255
Medicare Certified: 1987
Not Available
7246 janus park drive
liverpool, NY 13088
Provider Number: 337241
Medicare Certified: 1987
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1050 w genesee street
syracuse, NY 13204
Provider Number: 337052
Medicare Certified: 1966
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6007 fair lakes road, suite 200
east syracuse, NY 13057
Provider Number: 337119
Medicare Certified: 1966
Not Available
Headquarters: Oswego, NY 13126
Primary Phone: 315-349-3484
Last Update: 12-15-2018


text: I bought 5 FB PVA's, and have started sending out friends request using F___book Blaster Pro. I'm now all of a sudden getting captcha's, what's up with that? I've used FFB alot and have just recently been getting the captcha's. Has FB changed something? The accounts HAVE been phone verified, so I don't get it.


text:
12 Amazing Facts About Earth
gcontentPublished: November 24, 201618,177 views
Published: November 24, 2016
Over 7 billion people live here, yet the majority know very little about our world. There are many wonderful things to learn about planet Earth. Here are 12 amazing facts to get you started.
Frost Waltz (Alternate) by Kevin MacLeod is licensed under a Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/)
Source: http://incompetech.com/music/royalty-free/index.html?isrc=USUAN1100531
Artist: http://incompetech.com/


text:
3 credits
This course provides an in-depth review of the fundamentals of probability and statistics, followed by the measurement of various risk types. The course examines instances of market failure, the role of collateralization requirements, the impact of term, time horizon, and covariance, and extreme value
theory. The course also covers probabilistic and stochastic risk modeling, calculations of value-at-risk, stress testing, and other risk metrics, and the limitations of each of these measures.
Prerequisites: Prereq. Or coreq.: RM 701, Risk Management.


text:
THE force is strong with Britain's film industry - so much so that producers are combing the galaxy for accountants to join them.
The Production Guild of Great Britain wants to recruit nine people to become assistant production accountants on major features films in the UK.
The industry group is offering to provide training to help people working in accountancy in other industries to transfer their skills.
The guild's 10-month scheme includes placements on film and television drama productions, a tax-free training allowance of £300 a week and some travel costs.
Recent trainees have worked on productions including Star Wars: Episode VIII, The BFG, Assassin's Creed, Mr Selfridge and Bridget Jones's Baby.
Alison Small, chief executive of the Production Guild, said: "The training scheme provides practical training for people wanting to work on film productions.
"Over the past eleven years we have successfully attracted qualified people from other industries to transfer and augment their skills and build careers working in UK film and television."
Ruby Avards, a course graduate, has worked on films including Cinderella, Red 2 and The Tunnel. She said: "Even though I had a good job as the assistant revenue accountant for a leading holiday park company, I wanted to join an industry I could develop my career in.
"I can honestly say it was one of the best decisions of my life."
The course is supported by the Skills Investment Fund. The closing date for applications is January 22.


text:
A spokesman for the firm also accused the Senate Permanent Subcommittee on Investigations of cherry-picking four e-mail threads out of 20 million pages provided by Goldman, and reaching conclusions before it even holds a hearing.
In response to a selective e-mail release and statement from the subcommittee chairman, Sen. Carl Levin, D-Mich., Goldman Sachs spokesman Lucas Van Praag said the firm actually lost more than a billion dollars in residential mortgage-backed securities during the period in question.
"Today we have made available our residential mortgage profit & loss information for each quarter of 2007 and 2008. This demonstrates conclusively that we did not make a significant amount of money in the mortgage market," van Praag said. "What it does show is that we had net losses of over $1.2 billion in residential mortgage-related products in the period."
In addition, Goldman has released a 12-page summary document it had prepared in advance of Tuesday's hearing, during which CEO Lloyd Blankfein is scheduled to testify.
In that statement, Goldman asserts it never created mortgage-related products that were designed to fail, nor did it engage in "some type of massive bet against our clients."
Goldman Sachs: Risk Management and the Residential Mortgage Market
The e-mails released Saturday morning show top executives at Goldman Sachs Group Inc. boasting about the money the firm was making as the national housing market collapsed in 2007.
The e-mails suggest Goldman benefited from its bets that securities backed by subprime mortgages would lose value. The messages seem to contradict previous statements by the investment bank that it lost money on the securities.
"Of course we didn't dodge the mortgage mess," Blankfein wrote in an e-mail dated Nov. 18, 2007, according to an e-mail released Saturday. "We lost money, then made more than we lost because of shorts."
Goldman restated its position Saturday that it did not reap huge profit from bets against the market.
Short positions are bets that the market will go down. As the housing bubble burst, Goldman and a few powerful hedge funds took short positions on the market. Many of those bets required other investors to bet the market would rise. When the market went bust, people with short positions cleaned up.
"We were just smaller in the toxic products," Goldman's president, Gary Cohn, writes back to Blankfein that same Sunday evening.
Critics say their bets added fuel to the financial crisis.
More on Goldman Sachs:
Goldman's CEO, Board Named in Lawsuits
SEC Inspector General Will Investigate Timing of Goldman Case
Spitzer: SEC Will Likely Win Case Against Goldman Sachs
Analysts Bullish on Goldman, Despite Charges
SEC vs. Goldman: A Matter of "Material"
One of those bets is at the heart of civil fraud charges the Securities and Exchange Commission filed against Goldman this month. The SEC says Goldman let hedge fund Paulson & Co. help select investments for a portfolio that was designed to lose value, then marketed the deal to investors who were betting the portfolio's value would rise.
The SEC says Goldman did not tell the investors - mostly European banks - that the deal was created in part by the hedge fund and therefore was designed to fail.
Separately Saturday, Goldman released a series of e-mails from Fabrice Tourre, the trader at the heart of the SEC charges. In them, Tourre jokes about selling investments to "widows and orphans" when he already expects the market to go bust.
He writes in an e-mail dated March 7, 2007, that Dan Sparks, leader of Goldman's U.S. subprime business, said the business "is totally dead, and the poor little subprime borrowers will not last so long!!!"
That April, he joked about the bonds the SEC charges he misled clients about.
"I've managed to sell a few abacus bonds to widows and orphans that I ran into at the airport, apparently these Belgians adore" the complex investments, Tourre wrote.
The e-mails are in a mixture of French and English, and are to a woman with whom Tourre appeared to be romantically involved. Goldman provided translations.
The same e-mails were excerpted in the SEC's complaint against Goldman, but the full context was not reported previously.
The subcommittee, whose probe is not connected with the SEC's, has been investigating the causes of the financial crisis for 18 months. Its fourth and final hearing Tuesday will include testimony from Blankfein and Fabrice Tourre, a trader named in the SEC case.
Goldman has denied wrongdoing and says it will fight the charges.
In a statement Saturday, spokesman Lucas Van Praag said the bank lost $1.2 billion in the residential mortgage market during 2007 and 2008.
Blankfein's comment about Goldman making more than it lost was a response to an e-mail from Van Praag in which Van Praag discussed a forthcoming New York Times article about the firm. It would show "how we dodged the mortgage mess," Van Praag explained.
In one, Goldman Chief Financial Officer David Viniar says that in one day the firm made more than $50 million on bets that the housing market would collapse, according to a statement from Levin's office.
Viniar, also scheduled to testify Tuesday, summed up the position of investors who had not bet against the market:
"Tells you what might be happening to people who don't have the big short," Viniar writes in the message dated July 25, 2007.
In a statement today, Levin called banks like Goldman "self-interested promoters of risky and complicated financial schemes that helped trigger the crisis."
Goldman said in its 2009 annual report that its short positions sought to offset its long positions in the mortgage market and did not generate large profits. Through 2006, Goldman "generally was long in exposure" in the mortgage-backed securities market, according to the report, and after taking losses on those securities in 2006 it reduced its exposure.
"Although Goldman Sachs held various positions in residential mortgage-related products in 2007, our short positions were not 'a bet against our clients,'" according to the report.


text:
Housefull 3 Official Trailer | Akshay, Riteish, Abhishek: The much awaited trailer for the biggest laugh riot of the year is here! Housefull 3 stars Akshay Kumar, Abhishek Bachchan, Riteish Deshmukh, Jacqueline Fernandez, Nargis Fakhri and Lisa Haydon.
Cast: Akshay Kumar, Riteish Deshmukh, Abhishek Bachchan, Jacqueline Frenandez, Nargis Fakhri, Lisa Haydon
Directed By: Sajid-Farhad
Produced By: Sunil A Lulla, Sajid Nadiadwala
'Housefull 3' releases in theatres on 3rd June, 2016.


text:
to Magazine
Georgia gained independence in 1991, thousands of families
have been uprooted and torn apart by the tensions caused by
the secessionist aspirations of Abkhazia and South Ossetia.
The stories of three women poignantly attest to the suffering
these people have endured.
The house was engulfed by flames. Galina was lucky to have
escaped alive. Despite her panic, she tried desperately to
go back into the burning building to save some vestige of
her past — papers, photos — memories of her happy
life in Abkhazia from 1969 until the terrible war of 1992–1993.
Others attempted to restrain her. She struggled, weeping,
until the walls collapsed and everything she owned was reduced
to ashes.
Thus began a new life for Galina. She could remember almost
nothing of her previous one. Someone took her to a small place
on the outskirts of Sukhumi and told her she could live there.
"The owners have fled," she was told. "If
they come back, all you have to do is leave." The house
had a garden with fruit trees, a vegetable plot and flower
beds. Whenever she heard the sound of aircraft or bursting
bombs, she would panic.
Once the war was over, Galina's memories began to come
back in jumbled pieces. Doctors diagnosed stress, shock, depression
and partial amnesia. Galina realized that the war had shattered
her life. She wandered through the ruined streets of Sukhumi
searching vainly for familiar faces, taking on housework to
make ends meet. But her efforts to track down some scrap of
her past proved fruitless. As it happened, Galina still had
family in Kazakhstan, where she had grown up, studied and
married. In 1969, the young couple moved to Abkhazia, where
Galina's husband, a builder by trade, worked on the
construction of a hydraulic plant on the banks of the Inguri
River. They lived in the town of Primorskoye, and Galina had
a job on an industrial poultry farm. In 1985 they resettled
in Sukhumi, but things didn't work out as they had hoped
and the husband went back to Kazakhstan alone. When their
three daughters — Ira, Valia and Tania — grew
up, they also left to join their father and pursue their studies
in Kazakhstan. Galina was happy that her daughters were receiving
an education. Of course she felt lonely, but she had her job,
her neighbours, her friends. Then came war with its attendant
horrors — and her house burned down.
Recently a woman working for the ICRC knocked on the door
of the house she was living in. "Are you Galina Rakhmanova?"
she asked. "Your relatives are looking for you."
Throughout the years since August 1992, her children, her
mother and her sister had been actively searching for her
and had submitted a tracing request to the Red Crescent Society
of Kazakhstan. Liana Abidzva, from the ICRC mission in Abkhazia,
undertook a number of steps to check whether the elderly lady
living in the little house hidden by vegetation was indeed
the person they were looking for. After talking with her family
on the telephone, Galina exchanged news with them by means
of Red Cross messages. A copy of her birth certificate, destroyed
in the fire, was obtained and Galina was finally allowed to
return to Kazakhstan to be reunited with her family and retrieve
her lost memories.
Liliana Jakovleva
Liliana Jakovleva is a journalist in Sukhumi.
"Who knows how many lives have been destroyed by the
conflict between Georgia and Abkhazia, how many dreams have
been broken?" says 47-year-old Liuba, who had found
refuge from the violence in the garrison town of Senaki. "We
had a good life before then," she adds sadly.
Liuba's family is no stranger to the horrors of war.
Her husband fought and was wounded near the village of Gumista
in Abkhazia. "Miraculously, we managed to escape and
reach Tbilisi with our three children in tow. The youngest
was only two years old. We thought our troubles would soon
be over, but we were dogged by misfortune. It has been more
than 13 years now. When my husband died, I was left alone
with the children. Icouldn't even afford to bury him.
Some soldiers kindly did it for me," she says with tears
in her eyes.
"I had to raise my three children alone. Now Guiga
is 21. He is a boxer, a born athlete, and he has taken part
in several European competitions. He was on the boxing team
of the academy where he studied. He was a good student and
gained many honours for his academic and sporting achievements.
Now he is married and living in Tbilisi, where he is a contract
worker for the Georgian army. As for my daughter-in-law —
who is from a well-offfamily — she is studying medicine.
Poverty sometimes makes me suicidal, but then I look at my
children, remind myself of what we have been through, pull
myself together and rediscover the joys of life.
"David, my second son, is in secondary school and says
he will only marry a girl from Sukhumi. I believe in God and
count on his help. This war makes no sense. The Georgians
and the Abkhaz have always got on well together. The staff
of the post office where I worked was multinational and we
were a close-knit team. Tomorrow,Thursday, is the day the
Red Cross messages arrive. Last week I wrote one, so I'm
hoping for a reply so that I can get through another week
without worrying."
Eka Minjoraia
Eka Minjoraia is ICRC field officer in Zugdidi, Georgia.
Valentina, who comes from Abkhazia, was separated from her
family and is now living in Senaki. Her former life seems
like a distant dream. Life is indeed harsh for the countless
people who have fled the conflict between Georgia and Abkhazia
and settled in different villages in the districts of Mingrelia
and Upper Svanetia.
"We used to harvest up to 12 tonnes of tangerines and
a tonne of tobacco leaves. Our cows weighed more than a tonne
each and produced 20 litres of milk a day. We made huge quantities
of cheese," says Valentina. She used to work as a seamstress
in Sukhumi. "I earned 100–150 roubles a month
making wedding dresses. I had been at the factory for 25 years
and never had a problem with any of my colleagues. When fighting
broke out, we thought it would only last three days. Well,
13 years later we still can't go home. At the time,
my daughter was 4 years old. With Sukhumi under bombardment
and in flames, we fled, leaving behind all our belongings.
We had to cross the Chuberi-Sakeni Pass on foot. On the way,
my parents and brother were taken prisoner.
"In Senaki we were given two rooms in a disused hotel.
The Red Cross provided us with mattresses and household items.
Later, they brought me a sewing machine, which enabled me
to make clothes to exchange for sugar, bread, tomatoes and
other food. Now I sell second-hand clothes, as my eyesight
is failing and I can no longer sew.
"I keep in touch with my brother in Abkhazia by means
of Red Cross messages. My parents also live there, even though
their house was burned down.
"What can we do? We are not responsible for what happened,
but we are the ones who suffer the consequences. They say
that time heals all wounds. That is what I am counting on."
Many buildings bear the scars of fighting in Sukhumi in 1992–1993.


text:
Giant Hummer
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text:
from Wiktionary, Creative Commons Attribution/Share-Alike License
- adj. Without eyelashes.
from Wiktionary, Creative Commons Attribution/Share-Alike License
Lena looked past them, to the tiniest of tiny birds, all curled limbs and pointed bottom, the blue pulses visible, the waxy pink lips, the dry skin of a wizened elder, the heaving chest, the huge lashless eyes.
He went back to his men with a shiver between his shoulder-blades, and the mullah, standing in the gap of the mosque wall, blinked at him with lashless eyes.
"Many have entered!" sang the lashless mullah in a sing-song chant.
"Words at the gate -- proof in the cavern!" howled the lashless one.
"Kurram Khan!" the lashless mullah howled, like a lone wolf in the moonlight, and King stood up.
He approached until he could see the pattern on the covering rugs, and the pink rims round the mullah's lashless eyes.
The mullah in the arena, blinking with his lashless eyes, held both arms up for silence in the attitude of a Christian priest blessing a congregation.
As he forced his way forward a man passed him up the wooden box that King had used to stand on; he seized it in both hands with a grin and a jest and went to stand behind King and Ismail, in line with the lashless mullah, facing Yasmini.
Though the head was scuffed and its nose and prominent features worn to near smoothness, the minute, lashless eyes still blinked, and the mouth moved spastically, though no sound could be heard.
She was always well put together, and even though she looked pale her lashless eyes were still piercing.


text:
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text:
Phosphorus fractions under different land-use systems in oxisols of the Brazilian cerrados
TypeBook Chapter
AccessibilityUnrestricted Access
MetadataShow full item record
Westerhof, Roelof; Silva, José Eurípides da; Ayarza, Miguel Angel; Zech, Wolfgang. 1999. Phosphorus fractions under different land-use systems in oxisols of the Brazilian cerrados. In: Thomas, Richard J.; Ayarza, Miguel Angel (eds.). Sustainable land management for the oxisols of the Latin American savannas: Dynamics of soil organic matter and indicators of soil quality. Centro Internacional de Agricultura Tropical (CIAT), Cali, CO. p. 146-158. (CIAT publication no. 312)
Permanent link to cite or share this item: http://hdl.handle.net/10568/55135
External link to download this item: http://ciat-library.ciat.cgiar.org/Articulos_Ciat/biblioteca/Sustainable_land_management_for_the_oxis.pdf#page=155
We examined whole-soil samples and particle-size fractions to study the distribution of different phosphorus (P) fractions after land-use change from native savanna to crops, pasture, and reforestation on clayey and loamy Oxisols of the Brazilian savannas. Phosphorus was extracted sequentially, according to a modified Hedley procedure, into inorganic and organic P (NaOH-extractable Pi and Po, respectively), and recalcitrant P (P HCl and P res). Under natural conditions of strong P deficiency, over 60% of NaOH-extractable P was organic, reflecting the high contribution of P. to plant nutrition. Fertilization elevated inorganic P forms but had only small effects on Po. The increase of inorganic P forms from fertilizer P was greatest in the P, and lowest in the fractions. After fertilization, the reforested sites maintained high NaOH-extractable P through efficient recycling, whereas at the crop and pasture sites, P tended to accumulate in recalcitrant forms. Possibly, the adsorption of P to oxyhydroxides was reduced at the more acid reforested sites by complexation of Fe and Al oxides with organic acids. The ratio of NaOH-extractable P. to P. appeared to effectively reflect the P status of the land-use systems, and P deficiency increased in ascending order from native savanna > pasture > reforestation > crop, independently of soil type.
AGROVOC Keywords
SubjectsLAND USE; SOIL HEALTH;
RegionsLATIN AMERICA; SOUTH AMERICA
- CIAT Book Chapters [1973]


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Hundreds of people across Durham Region and the GTA are targeted by clever and unscrupulous fraudsters every week. Whether by phone, email, or at the door, fraudsters are looking to benefit at the expense of trusting citizens. Many residents of North Durham have been victimized, losing hundreds, or in some cases thousands of dollars, or having their personal identity compromised.
The Cannington Neighbourhood Watch is hosting a free Fraud Awareness Information Night on Tuesday April 29, 2014 from 7:00 - 9:00 p.m. at Trinity United Church. The goal of this training is to equip members of the community with a greater awareness of the kinds of frauds and scams that are being perpetrated in Durham Region at this time.
This is your opportunity to come out and learn how to protect yourself and your loved ones from becoming a victim of fraud, and also to learn more about local safety programs such as Road Watch and Neighbourhood Watch. There is no cost, and pre-registration is not required. Be wise – don't get scammed – be informed!
WHAT: Fraud Awareness Information Night
WHEN: Tuesday, April 29, 2014, 7:00 p.m.
WHERE: Trinity United Church
50 Laidlaw Street North, Cannington
WHO: Cst. Dawna Murray
Morgen Dobson
For more information, please contact Regional Neighbourhood Watch Coordinator Morgen Dobson at 1-888-579-1520 ext. 5610.
community watch thumb (JPG file, 45.1K bytes)
Community Watch poster (JPG file, 459.2K bytes)


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The cream/mascarpone layer is made with yogurt, cashew cream & coconut oil!
- Yield
- 8
- Active Time
- 30min
- Total Time
- 6hrs
- lady fingers
- For the filling:
- 625 g yoghurt (22 oz)
- 200 g raw soaked cashew nuts (7.1 oz)
- 3 tablespoons all-purpose flour or 1/2t agar
- 150 g powdered sugar (1 1/4 cups)
- 130 g coconut oil, melted (1/2 cup+2T)
- 1 T vanilla
- 240 ml freshly brewed and cooled coffee (1 cup)
- 2-4 tablespoons coffee liqueur or Amaretto, to taste
- 1-2 tablespoons unsweetened cocoa
- dk chocolate shavings for garnish
- Soak cashews for 8hrs In a food processor, combine yoghurt & cashew nuts process until smooth. Add flour & sugar process to a smooth paste. Pour coconut oil & vanilla into the mixture and process until smooth again. You want the mixture a little runnier then you like your tiramisu bc it will thicken a bit in the fridge. Soak ladyfingers in the coffee & alcohol until almost thoroughly soft (they will soften more after combined. Pour half of the filling over the ladyfinger layer, distributing it evenly. Place second layer of soaked ladyfingers, pour remaining filling on top. Sift cocoa over the tiramisù and transfer to fridge. Let sit for several hours or overnight.
Related Video
Nutritional Info
- Calories423
- Carbohydrates36 g(12%)
- Fat29 g(44%)
- Protein8 g(16%)
- Saturated Fat16 g(82%)
- Sodium41 mg(2%)
- Polyunsaturated Fat2 g
- Fiber1 g(5%)
- Monounsaturated Fat8 g
- Cholesterol10 mg(3%)


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The Washington County Show Kids, under the direction of Brenda Cauffman, will travel to Florida in February to compete in Twirl Mania at Disney's Wide World of Sports Complex
The girls will be entered in individual events, dance twirl teams and will have the opportunity to march down Main Street Disney in a parade.
Several fundraisers are taking place, such as a Christmas bazaar planned Saturday from 10 a.m. to 2 p.m. at St. Andrew's United Methodist Church on Maryland Avenue.
Soup, sandwiches and baked goods, as well as several vendors will be on hand.
The team is also selling raffle tickets for a chance to win two prizes of $100 each, which will be drawn Jan. 7.
Another raffle will be held after Christmas with prizes being donated by local businesses and friends.
The girls have been seeking individual sponsors as well as team sponsors. If anyone is interested in helping them meet their goal by donating an item or making a monetary donation, call Donna Conway at 240-217-5111.
Santa to ride through Boonsboro
Santa Claus is coming to town, and through town. The man in red will cruise around Boonsboro on a fire truck, visiting local developments in the Boonsboro and surrounding area. Candy canes will be provided to children who come and say hello to Santa.
Santa plans to visit Wednesday, Thursday and Friday from 6 to 8 p.m. Santa and the fire truck will be visiting Fletchers Grove, Main and Potomac streets, Greystone, Crestview Estates, Kinsey Heights, Grove Lane, Roxbury Estates, Wilderness Run Estates and Thacker Drive.
Movie night
"The Music Never Stopped" (2011, Rated PG), a teen and adult movie, will be shown at the Boonsboro Library on Friday, Dec. 16, at 6 p.m. The movie follows a family who is learning to cope with the sudden return of their estranged son, Gabriel. Due to a brain injury, Gabriel's memory only functions while being inspired by his favorite music from the 1960s. To register, call the library at 301-432-5723.
Family to gather
The Roy Grams Family will celebrate Christmas together with a gathering at Rohrersville United Methodist Church Sunday beginning at 12:30 p.m. Ham and turkey will be served, so bring along a side dish to share, along with some nonalcoholic drinks. Johnny Brubaker will run the meeting.
Band concert
Boonsboro High School's Band will share the spirit of the season through music at its winter concert Tuesday, Dec. 20, 7 p.m. Admission is by donation. Canned goods will also be collected at the door for the local food pantry. A silent auction of several items will be held, and refreshments will be served following the concert.
Share your news
Call 301-432-8615 (leave message) or email firstname.lastname@example.com


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Monday, April 2, 2012
Jennifer Jilks, retired teacher and educational writer, moved to Muskoka to care for her failing parents. Her intent: to write a book about teaching. Leaving behind friends, family and support systems, she was forced to retire early due to caregiver stress, depression and burn-out. Rather than the book about teaching, she participated in helping her parents navigate through end-of-life issues and wrote of her journey helping her parents die with dignity.
Her mother died at home from cancer, and her father from a brain tumour while in Long-Term Care. Part memoir, part research, the book includes coping strategies, and information discovered about the maze of Ontario Health Care options. Living and Dying With Dignity follows her parents' journey, carefully explaining what happens after the diagnosis of cancer. Many have written success stories, but how do you cope when cancer or a brain tumour returns, when juggling as an adult child and a caregiver? What are your rights?
Author of many educational publications, and a school teacher from grades JK to 8, with workshop presentations ranging from Internet Safety, Web Design for Students, Integrating Technology for Exceptional Students, Jennifer has turned these skills towards adults.
Her work with the young has been transferred to working with older adults as a Peer Health Educator with the Cardiovascular Health Awareness Program, a Consultant with the Provincial Aging at Home Strategy, and a blogger: ontarioseniors.blogspot.com
The book's first section is a memoir, which deals with the emotions of relocating, finding care and suitable supports for her parents. The second section is a research-based section with helpful advice. Since the senior generation are often reluctant to ask questions, and people often don't know which ones to ask, this book includes information about your rights as a patient, i.e., treatment plans, discharge options, and questions to ask your oncologist. You have a right to know treatments, treatment symptoms, options, and quality of life issues. There are many barriers to getting health care in Canada.
Posted by Jenn Jilks at 5:39 PM 1 comment: Links to this post
Labels: biography
Table of contents: my book on Ontario palliative home care and LTC
My book is part memoir, part research-based. Since my parent's generation were reluctant to ask questions, and I didn't know which ones to ask, I have included information about your rights as a patient, i.e., treatment plans, discharge option, and questions to ask your oncologist. You have a right to know treatments, treatment symptoms, options, and quality of life issues. There are many barriers to getting health care in Canada.
The capitalized headers are chapter titles. The lower case sentences explain chapter content.
2002: THE RAVAGES OF OLD AGE - aches and pains become issues, multiple comorbidities.
2003: MOM'S SURGERIES; DAD'S SEIZURES - both have surgery: Mom for leukplakia, Dad has his brain tumour removed.
2004: STRESS--AND MORE STRESS - my caregiver story as I juggled work, parenting, and parenting parents.
2005: INDEPENDENCE ISSUES - no longer can they manage their ADL and IADLs.
2006: MOM'S PASSING - Mom passed away at home and no one told us about Hospice volunteers. There were endless trips via ambulance to hospital. Dad was having radiation treatment 200 km to the south in Toronto during this time. He became delirious with infections, a risk from radiation no one told us about. He was sent home from emergency with no Rx, unable to use the toilet.
2006: THE WRITING ON THE WALL - Dad's brain tumour grew back. He lost cognitive and executive function. I wrote about our search for Long-Term Care.
2006: I, CAREGIVER - How difficult to feed Dad almost every day, with anticipatory mourning. I went on anti-depressants and had to stop working at my teaching career. I was depressed with bereavement issues, menopause, as well as stress from work.
2007: DAD'S PASSING - I wrote about his final months, weeks, days as I fought for care, medications, support from health care. I provide information on physically and emotionally providing care, i.e., mouth care while dying.
THE STATISTICS OF THE SENIOR YEARS - how many of us have pain and multiple medical issues? Read about: cholesterol and depression.
ONCOLOGISTS - What questions to ask - what to expect and what are your rights?
LYMPHEDEMA - When a lymph node is removed there is swelling and the potential for clots.
BRAIN TUMOURS 101 - diagram of brain function. Dad lost his retrieval of nouns and had other communication and cognitive issues.
DEMENTIA AND DELERIUM - What is the difference? It is important to know.
SYMPTOMS AND BIOLOGICAL CONSEQUENCES OF DEMENTIA - Plaque build up in the brain prevents the brain from processing information and results in behavioural, social and emotional disorders.
MEDICATIONS - Are you at risk for polypharmacy? Do Medscheck.
CAREGIVING IN CANADA - What are your rights as care recipient or caregiver? What can you expect? Sources of information: check out my senior's blog.
PATIENT NAVIGATOR - This works well for Alzheimer's patients: First Link or the support from the Cancer Society, but we all should have the benefit of an advocate.
INTRACRANIAL PRESSURE: SYMPTOMS - What can you expect with a brain dysfunction?
SWALLOWING DIFFICULTIES (DYSPHAGIA) - This is a 'normal' part of death and dying as the body shuts down.
CANADIAN CANCER SOCIETY - They are a valuable source of referrals and references. Peer counsellors can help you. They also provide specific disease-related information.
GERIATRIC ASSESSMENTS - This is crucial in preventing or ameliorating dementia symptoms.
FAMILY MEMBERS AND AILING SENIORS - What are your rights?
QUALITY OF LIFE AND END-OF-LIFE CARE - Where do you go for help? Get a geriatric assessment.
CAREGIVING IN THE HOME - It is difficult and youare at risk for stress.
STRAINED FAMILY RELATIONS - Many dysfunctional families become worse.
CAREGIVING BY OUTSIDE AGENCIES AND SUPPORT WORKERS - Who you gonna call?
PLACING A SENIOR IN LONG-TERM CARE - what to take, what to leave,
RESIDENTS' RIGHTS AND NEEDS - Bill of Rights
THE ONTARIO BILL OF RIGHTS FOR RESIDENTS IN LONG-TERM CARE - available on-line.
VISITORS TO FAMILY AND RESIDENTS IN LONG-TERM CARE - what can you take? What can you do when visiting?
SUGGESTIONS FOR FAMILIES OF THOSE IN LTC - Be vigilant, visit frequently and at different times.
INDUSTRY ISSUES - Where are we headed?
Posted by Jenn Jilks at 2:00 PM 2 comments: Links to this post
Labels: brain tumour, caregiver stress, caring for parents, daughter, depression, health care, menopause, mouth care, palliative care, table of contents
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Grading the Tide: Alabama 13, Texas Tech 10
BOL provides a weekly report card for the Alabama football team during the 2005 season. Here's a look at how we graded the Crimson Tide in it's 13-10 win over Texas Tech in the Cotton Bowl.
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Anita Brooks-Kirkland addressed the consideration of the digital divide with a more specific focus on the learning divide. The digital divide is no longer about access to computers, but rather the disconnect between the way students use technology at school and in the rest of their lives.
A systemic 'fear factor' regarding security and content filtering raises the divide between institutional networks and how students are accustomed to using technology beyond the school. Furthermore, Anita challenges us to consider the construct of the digital native vs. the digital immigrant. It may well have become the biggest excuse for adults to not extend their learning in technology, with the lament, "Well, I am a digital immigrant after all!". Anita asserts that it is the propensity for curiosity that crosses that divide. She cites Christopher Harris who addressed that dichotomy and coined the updated construct of Digital Nature vs. Digital Nurture.


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The Gorge Amphitheatre|754 Silica Rd Quincy, WAFind an Airbnb | Rent an RV
Escaping city life and entering scenic views is a great kickoff to your Paradiso adventures. Regular parking at the amphitheater is included with the purchase of your ticket but there are other transportation options if you're feeling extra green. Book a shuttle service with Rock & Bus, which provides roundtrip rides for your party crew from the city of your choice, or carpool using Ricky Ride, Zimride, or Ridejoy.
Paradiso occurs at the height of summer and there are hardly any trees, which means you'll be exposed to the sweltering sun. Conquer the weather by wearing proper clothing, protective accessories, and sunscreen. Bring a Camelback or a reusable water bottle to ensure that you are hydrated. Find shade if you can and remember to relax in between sets.
Spend a few days before or after the festival to experience the finer side to Quincy County. Four wineries are a short drive away from The Gorge, including the Cave B Estate Winery, Jones of Washingtown Wine, and Beaumont Cellars. Sip on a glass of Chardonnay or Cabernet Sauvignon as you indulge in Quincy's grandiose scenery.
The campground opens at 1 pm on Thursday; all sites must be vacated by 12 pm on Sunday. VIP campsites (Premier, Terrace, and Gold) usually sell out quickly so if you're into the lavish festival lifestyle with showers, private restrooms, and other glamorous amenities (like free coffee and pastries), book now!
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Saturday, January 2, 2016
Episode 71: Getting Back into the Swing of Things
In episode 71 Jessica and Theresa catch up on their holiday break and how hard it is to get back into the swing of things (for adults and kids)! They talk about finding balance, New Years Resolutions and Jessica's Reading Resolutions.
This was their first time using Blab to record, so they were also learning how to use this new online tool to be able to connect with listeners during the live podcast.
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Wingate Inns Nisku properties are listed below. Search for cheap and discount Wingate Inns hotel prices in Nisku, AB for your personal or business trip. We list the best Wingate Inns Nisku hotels/motels so you can review the Nisku Wingate Inns hotel list below to find the perfect place.
This technology will also list Nisku, AB hotels & motels that have similar star rating to Wingate Inns.Need a group/meeting discount? Request a group rate for Nisku AB
How should we direct your call?


text: Hi there. I am interested in buying a used PowerBook. I was just seeking some advice as if I should spend money to get it. Thanks for all your suggestions in advance. Specs are as follows. For $1,200 CAD. (1,050 USD / 570 GBP) G4 1.5 Ghz 1.256 GB RAM ComboDrive Mac OS X Tiger with iLife Second to last, PowerBook revision. Pretty much mint condition except for the usual wear and tear. Includes an iLap cooling station and InCase carrying case. Also has AppleCare until 2008 - is it transferable? And finally, should I get it?


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Jersey magistrate sentenced to 15 months in fraud case
A Jersey magistrate has been sentenced to 15 months in prison after he was found guilty of fraud.
Ian Christmas was found guilty of defrauding an investor of £100,000 in a property investment scheme. The money was used to pay off debts.
Former financial advisers Russell Foot, James Cameron and John Lewis were also found guilty in the case and received four-and-a-half year prison sentences.
Mr Christmas has lodged an appeal with the Royal Court.
The court heard the four men had been involved in a property purchase in the United States, but had defrauded a number of investors to help settle debts.
Mr Christmas has remained in office as a magistrate throughout the case, but has not carried out the role since June 2008.
Senator Ian Le Marquand, a local politician, called for a review in public office system in the wake of the sentencing.
He said he wanted it to be made possible for a magistrate to be asked to leave their role due to loss of public confidence.
Currently a magistrate can only be dismissed by order of the Queen, and after a disciplinary investigation by a UK judge.


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Of Mice & Men
Cold World
Of Mice & Men
Cold World
Colored Vinyl, Includes Download Card
Release Date: 9/23/2016
After a lot of hype and anticipation, Of Mice & Men have returned with their brand new full-length, "Cold World". It has been over 2.5 years since the band released "Restoring Force", which debuted at #4 on the Billboard Top 200 with over 50,000 copies sold in its first week and more than 206,000 copies sold to date in the U.S. Of Mice & Men have spent the past couple of years growing into a well-respected rock act, earning praise from critics, their peers, and even their icons. They have been busy touring arenas and amphitheatres across the world with the likes of Linkin Park, Rise Against, A Day To Remember, Bring Me The Horizon, as well as sold out worldwide headline tours. For this album, Of Mice & Men once again enlisted the help of producer David Bendeth (Breaking Benjamin, Papa Roach, Paramore, Killswtich Engage) and the result is 13 agressive rock anthems that will satisfy the band's already strong and rabid fan base, while also appealing to the broader rock and metal communities. "Cold World" showcases the band's growth as both songwriters and performers. The band will enlist the same radio team who took 2 songs from Restoring Force to Top 20 on the Active Rock Charts, and they've provided them the best tools yet with songs such as "Real", "Away" and "Relentless". Frontman Austin Carlile returns and gives his most brutal and honest performance to date while, clean singer Aaron Pauley returns with his trademarked soaring choruses to further become a star in his own right. Of Mice & Men are currently on tour with Slipknot and Marilyn Manson, playing arenas and amphitheatres across the country. Once completed, they will then embark on a UK and US headline tour, followed by a worldwide arena tour with A Day To Remember. The past couple of years have been exciting for Of Mice & Men, but the future is even brighter. "Cold World" is sure to become a classic in the rock community.


text: These are cut&pastes from Minyanville that I will include in this thread. Feel free to throw your own on here... This is how people really get jobs in the industry. Through all out aggressiveness and passion. This cut&paste demonstrates how one guy didnt take "no" as an answer. If you dont have a degree from an Ivy League college, then your going to have to roll up your sleaves and get in people's faces. Pulling an aggressive and creative move is not a bad thing. Its like asking a woman out on a date. All they can do is ask you to leave and all you lose is "face" and time. However, thats all you lose. . . **************************************************** Ryan Krueger worked for free at a small brokerage firm in Austin while attending the University of Texas, and upon graduating was declined an interview request at Smith Barney in Houston. He went to that office anyhow and asked to work for the minimum, and started in the mailroom. Working toward the portfolio management side of the business, Krueger started to manage a discretionary portfolio for âthe few people who trusted himâ at the age of 23. Eventually, the results led to a group of private clients that made their homes in many states, and several countries. He left Smith Barney after 10 years as Senior Portfolio Manger, to start his own money management firm. Krueger formed a partnership with Michael Catalano, a New Yorker, who began his career at 14 Wall Street for the same brokerage firm but who had moved to Houston. They set out on their own and opened an RIA called Krueger & Catalano Capital Partners, LLC. They manage private accounts for wealthy families across two different actively managed portfolios, and are set to launch two private funds in 2006. In addition to writing a private investment letter each month for several years, Krueger has had articles published in various national publications, and has hosted his own radio show in Texas for 7 years. Krueger lives in Houston with his wife, daughter, and son. Ryan Krueger welcomes your feedback at email@example.com ****************************************************


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PAR-18-221: Fast-Track Development of Medications to Treat Cannabis Use Disorders (UG3/... - 0 views
MiamiOH OARS on 06 Dec 17The purpose of this Funding Opportunity Announcement (FOA) is to accelerate the discovery and development of medications to treat Cannabis Use Disorders (CUDs) using the UG3/UH3 mechanism. The objective is to advance medications toward the ultimate goal of obtaining FDA approval. Advances in understanding the cannabinoid systems and the effects of marijuana on the brain, coupled with the availability of both novel and marketed medications that may be efficacious to treat these disorders, offer unprecedented opportunities to develop safe and effective pharmacotherapies for CUDs. The compounds to be evaluated can be small molecules or biologics. They can be tested in pre-clinical models and/or for the clinical manifestations of CUDs or their consequences such as withdrawal, craving, or cannabis use relapse. Applications may focus on the development of new chemical entities, new formulations of marketed medications available for other indications, or combinations of medications that hold promise for the treatment of CUDs. The UG3/UH3 Phase Innovation Awards Cooperative Agreement involves 2 phases. The UG3 is to support a project with specific milestones to be accomplished by the end of the 2-year period. The UH3 is to provide funding for 3 years to a project that successfully completed the milestones set in the UG3. UG3 projects that have met their milestones will be administratively considered by NIDA and prioritized for transition to the UH3 phase. Investigators responding to this FOA must address both UG3 and UH3 phases.