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CROI 2011: Bruce Brew on neurological effects of AIDS
Bruce Brew, MBBS (MD) FRACP, Professor, St. Vincent's Hospital, Sydney, Australia
Dr. Brew presented to the young investigators at this year's CROI on the work that is being done and some of what he sees that still remains to be done in the field of neuroscience in HIV/AIDS. Here he discusses neurological markers, medications crossing the blood-brain barrier, scoring systems for toxicity and efficacy, future research in this field, and other neurological areas of disease, to collaborate and share good research that may evolve.
To download an audio mp3 file, right-click here and choose "Save".
13 comments:
"Unnecessary risks are being taken by patients seeking the liberation treatment." says Dr. Avneesh Gupte of the CCSVI Clinic. "It has been our contention since we started doing minimally invasive venous angioplasties nearly 6 years ago that discharging patients who have had neck vein surgery on an outpatient basis is contra-indicated. We have been keeping patients hospitalized for a week to 10 days as a matter of safety and monitoring them for symptoms. Nobody who has the liberation therapy gets discharged earlier than that. During that time we do daily Doppler Ultrasounds, blood work and blood pressure monitoring among other testing. This has been the safe practice standard that we have adopted and this post-procedure monitoring over 10 days is the subject of our recent study as it relates to CCSVI for MS patients."ReplyDelete
Although the venous angioplasty therapy on neck veins has been done for MS patients at CCSVI Clinic only for the last 18 months it has been performed on narrow or occluded neck veins for other reasons for many years. "Where we encounter blocked neck veins resulting in a reflux of blood to the brain, we treat it as a disease," says Gupte. "It's not normal pathology and we have seen improved health outcomes for patients where we have relieved the condition with minimal occurrences of re-stenosis long-term. We believe that our record of safety and success is due to our post-procedure protocol because we have had to take patients back to the OR to re-treat them in that 10-day period. Otherwise some people could have run into trouble, no question."
Calgary MS patient Maralyn Clarke died recently after being treated for CCSVI at Synergy Health Concepts of Newport Beach, California on an outpatient basis. Synergy Health Concepts discharges patients as a rule without in-clinic provisions for follow up and aftercare. Post-procedure, Mrs. Clarke was discharged, checked into a hotel, and suffered a massive bleed in the brain only hours after the procedure. Dr. Joseph Hewett of Synergy Health recently made a cross-Canada tour promoting his clinic for safe, effective treatment of CCSVI for MS patients at public forums in major Canadian cities including Calgary.
"That just couldn't happen here, but the sooner we develop written standards and best practices for the liberation procedure and observe them in practice, the safer the MS community will be", says Dr. Gupte. "The way it is now is just madness. Everyone seems to be taking shortcuts. We know that it is expensive to keep patients in a clinical setting over a single night much less 10 days, but it's quite absurd to release them the same day they have the procedure. We have always believed it to be unsafe and now it has proven to be unsafe. The thing is, are Synergy Health Concepts and other clinics doing the Liberation Treatment going to be changing their aftercare methods even though they know it is unsafe to release a patient on the same day? The answer is no, even after Mrs. Clarke's unfortunate and unnecessary death. Therefore, they are not focused on patient safety…it's become about money only and lives are being put at risk as a result."
Joanne Warkentin of Morden Manitoba, an MS patient who recently had both the liberation therapy and stem cell therapy at CCSVI Clinic agrees with Dr. Gupte. "Discharging patients on the same day as the procedure is ridiculous. I was in the hospital being monitored for 12 days before we flew back. People looking for a place to have the therapy must do their homework to find better options. We found CCSVI Clinic and there's no place on earth that's better to go for Liberation Therapy at the moment. I have given my complete medical file from CCSVI Clinic over to my Canadian physician for review." For more information Log on to http://ccsviclinic.ca/?p=866 OR Call on: +1 (404) 461-9560.
This comment has been removed by a blog administrator.ReplyDelete
Stem cells are "non-specialized" cells that have the potential to form into other types of specific cells, such as blood, muscles or nerves. They are unlike "differentiated" cells which have already become whatever organ or structure they are in the body. Stem cells are present throughout our body, but more abundant in a fetus.ReplyDelete
Medical researchers and scientists believe that stem cell therapy will, in the near future, advance medicine dramatically and change the course of disease treatment. This is because stem cells have the ability to grow into any kind of cell and, if transplanted into the body, will relocate to the damaged tissue, replacing it. For example, neural cells in the spinal cord, brain, optic nerves, or other parts of the central nervous system that have been injured can be replaced by injected stem cells. Various stem cell therapies are already practiced, a popular one being bone marrow transplants that are used to treat leukemia. In theory and in fact, lifeless cells anywhere in the body, no matter what the cause of the disease or injury, can be replaced with vigorous new cells because of the remarkable plasticity of stem cells. Biomed companies predict that with all of the research activity in stem cell therapy currently being directed toward the technology, a wider range of disease types including cancer, diabetes, spinal cord injury, and even multiple sclerosis will be effectively treated in the future. Recently announced trials are now underway to study both safety and efficacy of autologous stem cell transplantation in MS patients because of promising early results from previous trials.
Research into stem cells grew out of the findings of two Canadian researchers, Dr's James Till and Ernest McCulloch at the University of Toronto in 1961. They were the first to publish their experimental results into the existence of stem cells in a scientific journal. Till and McCulloch documented the way in which embryonic stem cells differentiate themselves to become mature cell tissue. Their discovery opened the door for others to develop the first medical use of stem cells in bone marrow transplantation for leukemia. Over the next 50 years their early work has led to our current state of medical practice where modern science believes that new treatments for chronic diseases including MS, diabetes, spinal cord injuries and many more disease conditions are just around the corner. For more information please visit http://www.neurosurgeonindia.org/
My name is David Summers of Murfreesboro, TN and I have had MS for 16 years. I am 37 years old and as of January 2012, was effectively an 8.0 on the EDSS scale. Originally RRMS, my disease progression had become SPMS (very progressive) within 4 years of onset. Normally anyone in my position and with my bleak diagnosis is limited to a short future, absolutely no quality of life and a painful end...possibly prior to my 40th birthday if the current progression of the disease continued (without the slightest hesitation or glimmer of hope, my Neurologist just told me: " Prepare to deteriorate"). But after I heard about Dr. Zamboni's 'liberation therapy hypothesis' in 2010, I began my search for the vein-widening therapy. This put me into a clinic in Duluth, Georgia where they were doing the liberation procedure. I received immediate positive results post-procedure...along with the surgeon's warning that 50% of the MS patients who undergo the liberation therapy suffer a re-narrowing of the jugular veins within a year or so. Sure enough, within 3 months I knew that I was going to be among the unlucky 50%; all of the original improvements disappeared as I relapsed.ReplyDelete
I felt the only way forward was to get it done again, hopefully this time with more enduring results. But where would I go to get this done again and how would that be possible? If my neck veins restenosed after the first treatment, what was to prevent that from happening again...and again? I began to read the Internet blogs and forum chats placed on the many new CCSVI sites by MS patients about where to go and what their experiences were. In this respect, the Internet became a valuable educational tool for me. On several of the blogs, I discovered a New York clinic where they placed a stent during the procedure to keep the jugular veins open, and that positive results were being seen. Grimly, I also discovered that although rare, the prospect of death as a result of this procedure was also a risk. At least one person in a recent study had died when the stent migrated to his heart. But I was willing to put those thoughts and the risks aside. What did I really have to lose? I was dying a slow death. As long as someone was able to treat me there was a chance to hope, and I was down for it. But that wasn't the main question I was asking myself.
As my disease rapidly progressed and my disabilities became more overwhelming, the question I was asking myself was, was it too late for me? Although I was happy with the fact that my original liberation therapy had diminished most of the symptoms above my waist, I had to ask myself if getting stents was merely settling for a compromised improvement. Having had some success, if I had this done again, I wanted more! Don't get me wrong, I think the liberation therapy is a miracle discovery from God. As soon as I had my first procedure my cog fog lifted, the vision in my right eye improved greatly, the numbness in both hands dissipated by a few degrees, my ability to taste food returned, my energy levels were 'off the charts', and my sleep was so sweet. Also, because MS had robbed my body of the ability to regulate body temperature by sweating, I had not been able to handle the hot, humid Southern summers where I live, except to blast cold AC non-stop as a survival method during those sickly 'dog days'. After the procedure this changed too. I knew it when deodorant suddenly became necessity for my personal hygiene once again!
For more information please visit our site http://davidsmsstemcelljourney.blogspot.in/
But it ended by the 90-day point and I was right back where I started. Immediately following the procedure I had dreams of rising from the wheelchair I'd been confined to for ten years and walking like a real man; but even with the incredible improvements overall, it seemed that the only healing occurred above the waist. Perhaps I would just have to accept that even if I could improve to what the full extent of the liberation therapy would allow, I would always be in a wheelchair. While researching the New York clinic and other places, my parents and I came upon CCSVI Clinic through a Google search. We discovered that they are essentially a research clinic operating under an IRB but with a major difference. For the past year, having seen even better results than just doing the liberation therapy alone, they have also been transplanting adult autologous stem cells, cultured and re-injected into the body shortly after the neck venoplasty. If I chose to go there instead of New York, the procedure would be done at CCSVI Clinic at Noble Hospital in Pune India and I would have to get there essentially as a partially paralyzed patient transported in a wheelchair. There would also be a requirement to stay in the hospital for 10-12 days. But after researching the improvements demonstrated in MS patients in stem cell clinical trials, I simply decided that as long as they would take me, nothing was going to stop me from making that trip. On calls with the clinic, it was also explained that stents were not necessary as the stem cells injected intravenously could be enough to keep my veins from restenosing. My confidence in their method increased when I discovered that Dr. Gupte, the neurosurgeon, had been transplanting autologous stem cells for 4 years for a number of different neurodegenerative conditions, including MS and based his therapies on completed stem cell trial methods done in a number of hospitals and universities outside of the US (to be absolutely sure, I confirmed this through searches on Google Scholar). He had already done over 2000 successful transplants! Regarding my communications with CCSVI Clinic, I need to confess here that we did not tell the doctors the truth originally. My mother, who arranged the treatments, told them that I was an EDSS 6.5 in order to qualify. Basically she knew that they wouldn't accept me into the program if she said I was higher. But if they saw my actual physical condition could they refuse me on the clinic steps? I hoped not.ReplyDelete
So in late March it was off to India with my father who is a strong man, and my capable assistant. We arrived on March 26, 2012, and met Surjo Banerjee, CCSVI Clinic's Managing Director at the airport. He drove us from the airport to Pune, a surprisingly modern city just south of Mumbai. I was amazed to see that the hospital and the CCSVI Clinic itself, (a full wing of suites within the hospital complex) was as clean and modern as any hospital here in the States. After checking in with a number of other patients, I was triaged for the procedures. However, based on my new assessment, it was determined that I would need about twice the amount of stem cells that they had originally programmed, figuring my EDSS scale requirement of 6.5. But paying more was out of the question. We are not rich and had basically 'sold the farm' to get here in the first place, and the recommended additional stem cells were going to cost another $12,000 that we had not planned for. Not their fault...I didn't tell them the extent of my condition in the first place. So the first miracle happened when CCSVI Clinic management offered to personally cover these additional costs. I had never even met some of them, but as a result of their generosity, I received an additional 50,000,000 mesenchymal stem cells and I cannot thank them enough for the difference they have made to my life.For more information visit our site http://davidsmsstemcelljourney.blogspot.in/
On Tuesday March 27ReplyDelete
, I once again had the liberation therapy followed by the harvesting of red bone marrow cells from my hip bone. The clinic has strict aftercare protocols around each type of procedure with regard to position control and movement. It didn't much affect my activity because I was unable to move much anyway. I was supine positioned, tilted slightly head high for two days following my venoplasty and then laid out supine again, in just the opposite tilt...head-lower-than-the-body for several days following the transplants of the stem cells. I was told that this would allow the newly transplanted stem cells to filter through the full length of the nervous system and locate to the points of injury. A Doppler ultrasound of my neck veins was done every day for 10 days following my liberation procedure. This was to check for any clotting or re-narrowing of the veins which had been widened. If they clotted or restenosed at any time I was in the clinic, they would take me back into the cathlab for a re-do. Happily this wasn't necessary.
Following the liberation therapy, the changes within my body were just as immediate and dramatic as in my first procedure in 2010, hopefully without the fear of re-stenosis; but my 'headspace' almost didn't accept it. The first time with my liberation therapy in the US, the IR found one narrowing in each jugular, the right side being more severe. This time around, two blockages were found on my right side, and again one on the left. I have heard that second and third procedures for venous angioplasty are more difficult for the surgeons because there is more build up of scar tissue in the interior of the veins, but the medical team took their time and did a perfect job. Words cannot express the emotional joy in getting the blood flowing again and getting those symptomatic improvements back a second time!
For more information visit our site http://davidsmsstemcelljourney.blogspot.in/
Four days later I underwent a lower lumbar puncture, but this time not simply to gather information on whether I have MS. This time, stem cells cultured from my own body were on their way to do what God designed them to do, and that is to heal. For all of you that might be skeptical about this, I am here to tell you that is exactly what they are doing. The positive changes were noticed as soon as I returned to my suite in the clinic and anyone who is paralysed below the waist will understand this next part. To manoeuvre myself as I usually do, I went to pick my leg up from a sitting position and throw it in front of me. The hope here is that the 'dead-weight' of the leg will land just right and in a position where I can best situate myself to haul my body into a position where I can further awkwardly throw my whole body into my wheelchair. If you've ever seen a spinal patient do this or are unlucky enough to have to do this yourself, you know what an ugly, uncomfortable process this is. But this time the 'throw' of the leg proved to be an over-compensation. To my absolute shock and delight my leg lifted itself just as it's supposed to work...without aid from my helpful hands and placed itself exactly where my brain told it go! At first I didn't think much of it...this was a fluke, maybe my imagination, but it was something sure not to last. But it has to this day without any hint of regression as I work out and get stronger. This was the first sign of any recovery whatsoever that has occurred below the waist in over ten years, and it happened only hours after the stem cell transplant!ReplyDelete
Upon returning home on April 14, 2012, I closely followed the Clinic's physiotherapy program. Since then I have been working out at levels I had been told by my doctors here in the states would not be possible again. When exercising before I had stem cell therapy, I always had to be careful not to overdo it because I would get a sickness that sometimes lasted 2 days, completely wiping me out. This even occurred after the first liberation therapy, but no more. I've been working myself silly and have not yet felt sick. Real strength has returned and muscles have been popping out in places on my body where I haven't seen them in many years. As of this writing today, and for about the last two weeks my right hand has been functioning normally in every respect. I'm not saying it has improved some, I'm saying it is now completely NORMAL! I can hardly believe it myself.For more information visit our site http://davidsmsstemcelljourney.blogspot.in/
Since I returned, and after only one month, the positive changes have been happening regularly and most every day. Most significantly, I think, my incontinence has completely improved and I am now able to almost totally control my urinary and elimination functions. All other disabilities aside, I think that this is one of the most important deficits that anyone with MS wishes they could get back! Incontinence is so embarrassing and not having control of that particular function somehow makes you feel lesser as a person. So I'm very happy to see the improvements there. My speech is back to normal. Although I never slurred my words, the thought process was oh-so-slow. Now my words come so quickly that I sometimes find myself stumbling over them...trying to say too much at once. I can't complain about that!ReplyDelete
I am convinced that CCSVI Clinic is on to important discoveries about MS. They have figured this out and are doing the sequence of therapies correctly and the addition of the stem cells completes the need to repair the nerve damage that's been done by the disease. In retrospect what they are doing suddenly makes complete sense to me. It's still early yet and I guess time will tell to what extent my motor functions will come back, but if the last month is any indication, it could be everything, which excites me so much. I don't know if that's too much to hope for, but it's the first time in 10 years that I've even really allowed the thought to cross my mind. The first fleeting thoughts of this after the original liberation therapy 2 years ago weren't realistic. The good changes didn't last. And consider this; a few months ago, I was in a wheelchair, in a permanent brain fog losing more of my independence and quality of life on a daily basis. All I had to look forward to was a deteriorating condition where others would have to take care of my every bodily function. Now I can't wait to wake up every morning to check myself out. If anything I'm too impatient and working out too hard. But at least I can! Given my current state of health and ability to live and function on my own, the thing that is very certain is that I have a much better quality of life back and that wouldn't have even been possible if it hadn't been for the lucky discovery of CCSVI Clinic through an Internet search. My family and I will be eternally grateful for what has happened no matter how this turns out. Thanks to Dr. Gupte, the other doctors, the medical team and staff at the Clinic who made this all happen for me, I'm looking forward to each day with new health and optimism! May God Bless them all!For more information visit our site http://davidsmsstemcelljourney.blogspot.in/
I have a long way to go, but as long as my jugular veins are wide open and the stem cells continue to clean up the mess those narrowed veins left behind, and damaged nerves continue to regenerate, I believe the sky is truly the limit! My main focus at this point is not only to rebuild muscle but to get my legs to work together, which will restore my balance.ReplyDelete
Every day is a new gift that allows me more recovery. I can hardly wait for each morning to see the next improvement! There's so much more happening in my body than I've even mentioned in this writing but I hope I've related the main message here...MS was my previous diagnosis.
I will be starting a blog on my progress in a week or two if anyone wants to contact me or follow my improvement. I'm sure there are many of you out there who are skeptical or would want to know how this is going for me. I'll post the site information back here once I have it up.For more information visit our site http://davidsmsstemcelljourney.blogspot.in/
While some MS patients who have had the liberation therapy are reporting long-term benefits from having the procedure, there are just as many for whom the 'liberation therapy' has failed as an effective therapeutic intervention. This doesn't mean that these patients didn't have some immediate benefits once the neck veins were opened; most did, but over time the veins restenosed again and their MS symptoms returned. In fact, having seen their MS symptoms almost totally disappear however briefly once their veins were cleared, patients who have restenosed want it done over again, as many times as necessary in some cases. However, there is now a new and growing subset of MS patients who have had vein widening venoplasty multiple times, usually to less beneficial effect each time, leading to the later discovery of so much intraluminal scar tissue by the second, third, or fourth attempt at re-opening the veins that the procedure cannot be performed again.For more information on the combination therapy protocol and study email to firstname.lastname@example.com or call 888-468-1554. http://www.ccsviclinic.ca/?p=1071ReplyDelete
Topical amongst this group are: vascular grafts, bioprosthetics with autologous source endothelialization, pig's veins, etc. The need to remove jugular veins and implant new vessels because they are so occluded, indicates the possibility that there was 'overtreatment' of the veins during the initial venoplasty procedure that eventually led to the formation of scar tissue (that is, if they didn't occlude with thrombin build-up (clots) immediately post-procedure). It's well-known that once balloons are expanded in those narrowed areas of the diseased neck veins, tearing and abrasion (desquamation) occurs intraluminally causing inflammation and bleeding. And healing within venous lumen damaged due to venoplasty typically takes many months and leaves lasting, lumen-choking scars. Lumen diameters are permanently decreased. The recent self-reporting of an alarming number of permanently blocked neck veins certainly begs the question to be asked as to what additional medical interventions need to be developed to avoid this kind of catastrophic damage.ReplyDelete
Because the definite risk exists that veins will become blocked as a result of the liberation therapy, this further indicates that there may not be recognition by the surgeons of the fragility of the neck vein structure, especially in patients that already have diagnosed venous disease (CCSVI), even though the procedure is considered to be 'minimally invasive'. No additional steps in the current liberation therapy protocol have either been taken or proposed by Interventional Radiologists performing the vein dilation to eliminate the risk of restenosis. To date the approach amongst the Interventional Radiologists who are performing this therapy on an outpatient basis has been: 'whatever happens, happens', post-procedure. It is incorrectly assumed that restenosis will always be 'correctable' in subsequent therapies if necessary. This is now clearly proving to be the wrong assumption.For more information on the combination therapy protocol and study email to firstname.lastname@example.com or call 888-468-1554. http://www.ccsviclinic.ca/?p=1071
Therefore performing additional effective therapeutic modalities that will avoid the normal cascade of healing events and consequential scarring in support the liberation therapy is vitally important to restore and maintain optimal central nervous system (CNS) drainage once the abnormal veins have been widened. Preliminary evidence from CCSVI Clinic patient case reports indicates that stromal cells injected through the catheter at the time of the venoplasty and applied directly to the damaged vein avoid the formation of both thrombin and scar tissue intraluminally, and that the veins heal very quickly with no evidence of scar tissue. After over a year of treating patients' veins with stem cells at the time of the liberation therapy, it may be hypothesized that the stem cells work to create more stable, stronger and more enduring veins resulting in long-term patency (optimal blood flow) and the subsequent avoidance of additional venoplasty procedures. Case studies on each patient treated with the combination therapy are now underway.ReplyDelete
David Summers of Murfreesboro, TN is one such MS patient now being case studied. David came to the CCSVI Clinic as a paraplegic MS patient evaluated at 8.0 on the Kurtzke EDSS scale. His MS had become secondary progressive and his rate of deterioration had increased dramatically by late 2011. In April of 2012, David was treated at CCSVI Clinic with the combination liberation/autologous stem cell therapy protocol developed by researchers at Regenetek Cellular Technologies. Liberation therapy was first performed and adult autologous stem cells were implanted into David's jugular veins at the time of his vein expansion. Four days later, a clinical dose of mesenchymal stem cells (MSCs), enhanced in vitro from the original autologous marrow source was implanted back into David's CNS via lumbar puncture. (Stem cells multiplied from an autologous source not only ensures that patients are receiving their own DNA, but studies have shown there is no risk of cell mutation resulting in the formation of cancerous cells).For more information on the combination therapy protocol and study email to email@example.com or call 888-468-1554. http://www.ccsviclinic.ca/?p=1071
David's MS symptoms not only began to improve immediately, but within four hours of his implantation, he began to feel sensation below the waist. This did not happen the first time he had his liberation therapy in 2010, nor in the 90 days following that procedure, the length of time that he said he had received some benefit as a result.ReplyDelete
Following the combination of stem cell implants at CCSVI Clinic, disappearance of his MS symptoms could possibly be explained by the liberation therapy, but his subsequent nerve and muscle regeneration over the last several months can only be accounted for by the rebuilding of the myelin and axonal fibers within the CNS. Only the implantation of pluripotent MSCs that can differentiate into neuroprogenitor cells can do this. Furthermore following his therapy, his frequent attacks of MS completely stopped, another known benefit of MSCs which express chemicals that 'turn off' the proteins expressed by the over-aggressive immune system attacking the CNS.
In the six months following his combination therapy at CCSVI Clinic, David began to walk and workout more frequently. At 108 days post-procedure he entered a formal physiotherapy program to improve his walking ability, balance and physical endurance. He has not had an MS attack since his therapies in April of 2012 and most of his MS symptoms have disappeared or reduced dramatically. His EDSS score has moved from an 8.0 to approximately 3.0 and he continues to improve.
Other MS patients not nearly as disabled as David was, having been treated at CCSVI Clinic, are now reporting dramatic improvement and many are now asymptomatic. This combination therapy protocol, meticulously researched and based on various clinical studies on autologous stem cell transplantation, has now been taken from the bench to the bedside for the first time. So far David Summers is one of dozens for whom the outcomes are producing therapeutically what the clinical studies have confirmed. More case study data is being produced and will make up the Prospective Cohort Study to be published later next year.
For more information on the combination therapy protocol and study email to firstname.lastname@example.com or call 888-468-1554.


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Coffee at the Summit has been a favorite haunt of mine for some time now, although I'd not nearly qualify as a regular. Since it is near my office, I typically just drop in for a to-go cup and quick hello to the owner- I enjoy his dedication to the community and, particularly, the youth as he promotes music education as a means of touching the hearts and lives of local youth.
From their website: "In a unique coffee house in the heart of the Aycock Historic District. We are dedicated to providing the residential and business communities with a welcoming place to fellowship and network with friends, family, and associates. We offer a delectable array of food and drinks to suit all tastes in a comfortable, friendly atmosphere that invites you to relax and enjoy yourself. Oh yes, we also serve an excellent cup of coffee !"
My (humble and totally unqualified) review:
- coffee: Upon entering I was given a large black coffee- Albeit flavored. I'm not into flavored coffees- they just don't taste as good as they smell, to me. But I did appreciate the service. My second cup was a delicious Americano- I'd say 3.5 out of 5. Tasty, hot and strong- A bit more water than In prefer, and no crema... although I'm not sure if this is a fair expectation. Somehow they pulled crema on an Americano in Paris, but don't know if that's typical.
- Atmosphere: An easy 5 of 5... absolutely love being in this 98 year-old victorian house. Amazing renovations highlight all the best features, includes a stunning wrap-around front porch.
- People watching: I'm amazed that there are not more folks wandering around this place. Three people stopped in for a bit, but not too long. I really think this business is just an undiscovered gem and hope that more people find it soon! To his credit the owner has kept the outside very unpretentious, althoug this may cause passerbys to not notice as much. Anyway, people watching oppotunites are few and far behind.
- Proximity to home: 7.45 miles from home- it takes me from 10 to 20 minutes to get here, depending on traffic. Not too close to home, although it is seconds from work and another establishment I frequent.
- Wi-fi: Is free and unlimited!
- Price: Went with a friend of mine and we paid $7.42 for four large coffees- $1.85 a cup! Outstanding.
- Music: Stan is a jazz aficiando and hence the music here is spectacular- and as it turns out, the cd we were listening to was made by the group of kids he teaches; I never would have guessed it- So interesting and professional...
- Miscellaneous:
- pros:
- Well thought design and atmosphere.
- Friendly and knowledgeable barista
- I proudly spend my money here, knowing that it is going to support a number of worthwhile issues/ causes- music education, reaching out to youth at risk, African-American owned small-business, etc...
- cons:
- parking is an issue- I'm not sure if the lot next door is permitted.
- the shop was not yet open when I arrived at 9am, but opened shortly thereafter. While inconvenient, this somehow added some charm.
- I really like to have my 'for here' coffee served in a mug, rather than a to-go cup. Nit picky- I agree.

subset: commoncrawl


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A1 Ceiling Specialists is a Twin Cities based Ceiling Repair company located in southwest Minneapolis. It's first-rate service and quality workmanship has set the standard by which all ceiling repair contractors are measured. 30 plus years in the industry has produced thousands of happy homeowners and repeat business. Our reputation has earned us a "Straight A" on Angie's List here in Minnesota.
Since 1980, A1 Ceiling Specialists pride's it's self on being clean, courteous, efficient, and extremely skilled. No job is too big or too small. Owner Larry Forsman does all the work.. no sub-contractors are used. He will work hard to earn your business, and his lower overhead means he has very competitive prices!With A1 Ceiling Specialists, you not only get professional results, but you get a fully insured, honest experienced contact in the Ceiling Repair business. We work closely with the home owner's needs, ensuring the best possible results for you. You are guaranteed clean, prompt service.
We offer ceiling and wall repairs, from water intrusion, smoke damage, plumbing cut outs, plaster failure and more..
Services also includes painting and sealing, to a variety of texture surfaces including acoustic spray, popcorn, knockdown or flat finishes.
Call Larry today for a free estimate!
(612) 927-5532
E-mail: email@example.com


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Floria Twin Quilt Set
Details https://www.belk.com/p/cf-floria-twin-quilt-set/7101038899353FQSET.html
Orig. $176.00$88.00Sale 88.00
Additional Information
The Floria quilt set features a medley of classic large and small floral prints, hand pieced together to blend vintage and shabby chic. Reversing to complementary stripes in a soothing sage green on a taupe foundation, this assortment allows you to create two stylish bedding ensembles.
- 3-piece set
- Reversible
- Machine washable
- Cotton
- Imported
California Residents
For orders being shipped to California, please click here for Proposition 65 WARNING.
Shipping Details
Shipping Details
This item ships directly from the vendor, usually within 4 business days. Shipping Details
Due to shipping weight restrictions, this item cannot be shipped to a PO Box.
Return Details
Returns are easy at belk.com. Easy returns


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Screenflex Room Dividers ~ Temporary Kids Sunday School Classrooms
Sunday School Classrooms are created by using Screenflex Portable Classrooms. Each storage cabinet comes with a dry erase board on either side of the unit. A set of 6'0″ room dividers are extend from the Tambour doors on each side of the unit.
Sturdy, durable and long-lasting, Screenflex portable walls are available in 6 heights and 6 lengths and 38 color choices. Units ship fully assembled and ready to use. Manage the space in your facility with Screenflex. Call us today at 800-553-0110 for a quote or to get a list of customers in your area.


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Silhouettes: An Old-School Craft That's Still Cool
We've been noticing a lot of silhouettes in our house tours lately. We thought they'd disappeared but they seem to be making a resurgence. They're cool, graphic and easy to do yourself, given a bit a patience, a little time, a strong light and a willing subject...
Or, of course, there are a number of websites that will transform a photo for you, like Simply Silhouettes, which we've blogged about before. Try the traditional, cameo-style profile or, perhaps, something a little more contemporary. And, as we've seen from our house tours, they look great in groupings.
- Girl42's Flickr, from the Apartment Therapy Group Pool
- Mark and Marissa's Chic Garden Party
- Max and Peter's Squeaky Clean Quarters
- Jeanine's Smooth and Soulful Home
- Wendi's Pioneer Modern


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RKP isn't really a news site, so the announcement that Amgen has renewed its contract with AEG Sports to continue its sponsorship of the Amgen Tour of California might seem odd material for a post. The reason it's here is because this isn't your garden-variety cycling news. This is big.
I confess, for weeks, more than a month, in fact, I've been writing the obituary for the Amgen Tour of California. I thought an announcement notifying cycling fans of the race's demise was a formality, so the news that the company has renewed isn't just a pleasant little news brief. This is big.
So why was I so down on the future of the Tour of California? Let me count the reasons.
- In the United States, races have a terrible history of folding after a sponsor's contract is up. The Coors Classic folded up shop following the 1988 race after the race's contract with Coors ended. Race director Michael Aisner approached Nuprin and Dodge, both of whom agreed to sponsor the race only to decline involvement at the 11th hour. The Tour de Georgia was notable for the fact that it's the only major U.S. stage race that managed to sign three different title sponsors—Dodge, Ford and AT&T.
- Losing a race director has had dire consequences for races. When Mike Plant left the Tour DuPont at the end of the 1996 edition, the prospective next sponsor (DuPont's contract was up) didn't have much confidence in the new race director and ultimately the race couldn't secure a new sponsor.
- The 2011 edition of the Amgen Tour of California got off to a rocky start with a stage cancellation and the start of a stage moved. Sponsors don't like to see their events not happen as planned.
- The 2010 and 2011 editions of the race were upstaged by doping revelations that cast cycling in an unusually negative light. Landis' and Hamilton's revelations made much bigger news than the typical positive test. Who wants to spend millions to sponsor an ugly press conference?
- The economy still sucks. It's why there's no Tour of Missouri and no Tour de Georgia. Finding sponsorship money is as unlikely as winning the lottery two days in a row.
In the U.S., races come to an end. That's the unfortunate reality. But these next two years could be key for the event's longevity; it's up to AEG to use the time to court (and land) a new sponsor. Make no mistake, this news is huge.
Image: John Pierce, Photosport International
5 comments
Janet D.
This news IS huge, and most welcome on a day when HTC announced it is closing up shop. As always, the good with the bad. Thanks for the boost!
I know this post is not about HTC-Highroad, but it boggles my mind that a team as competitive as them can't find a title sponsor. Is it because they are based in the U.S.? I can see the difficulty of an American company wanting to sponsor a European sport, but still. I would think more tech companies would be interested. I never would have purchased a Garmin prior to the 500, but in my races last weekend it appeared that they were in the majority (which makes it really a pain to pair the hear rate sensor).
In regards to Amgen, there sponsorship –especially in the face of the doping scandals, makes sense. By sponsoring a major cycling event they appear to be tackling the fact that a drug they make is used to cheat. I applaud them for that.
This is good news as the ToC has certainly grown in stature and continues to do so. Let's hope they don't go crazy again with the parcours and go all Giro d'Italia by taking stages too high too early in the season.
The Highroad news is really deflating. Add to that the merger of the two Belgian teams and there is an obvious void of Title Sponsors available around the Wold at the moment. The proposed Australian 'GREENEdge' team have yet to announce their title sponsor though they do have a backer with relatively deep pockets and a true enthusiasm for the sport. Things are tough.
Can we get the Arabs involved? They seem to be buying up European football teams by the bucket load!
This is BIG news Padraig, kudos to you guys keeping it going.
Not that it IS a money maker and it IS positive in all aspects FOR california, and as for other races it is business feasible….so why not…
it's (big races) something that seems to be the lowest common denominator in our country for some reason, and if the Amgen Tour is on pins and needles, the rest of them are tenuous at best. It just makes me bang my head wondering 'why not'….
Perhaps this CAN change in the future generations though….i sincerely hope


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Living in New York City, I see at least one thing a week that makes me think Oh. When people make fun of me for living here, thats what they make fun of me for. The west coast is not my home, and Im not as sensitive about how and when it is badmouthed, but I believe that when people make fun of California, they are making fun of things like Heavy Hawaii. The stereotype of the west coast guy whos completely obsessed with appearing laid-back is a well-worn one, but Goosebumps is such a carefully thought-out collection of things that read as relaxed in 2013 that it almost comes across as manic. The tempos never get above or below that mid-60s lurch. Unmemorable, trebly guitar lines abound.
The lead vocals on Goosebumps are pitched down to give a 45-on-33 effect. All of them. I just checked an online stream to make sure there wasnt something wrong with my review copy, and sure enough: All of the lead vocals on Goosebumps are pitched down. It doesnt read as experimental, or even as creative self-sabotage. It just comes across like Heavy Hawaii decided they were interested in those ideas and took the easiest, most odious possible route to get to them. Goosebumps makes enough extremely cynical assumptions about me as a listener that Im willing to make a cynical assumption about Heavy Hawaii and say that, at least for a second, they probably thought about DJ Screw while mixing the vocals. God, thats frustrating.
The queasy, cottonmouthed exhaustion that can come with being relaxed all the time is something worth reflecting on. Ganglians did a pretty good job with that, and when Sun Araw feels like showing up, hes been known to knock that type of thing out of the park. Goosebumps, and the lazy ways it plays on the conventions of its genre, sound so lackadaisical that, regardless of Heavy Hawaiis intent, the album is more a part of the problem than part of the solution. The moment when the vocals come in on this bite-sized sample of Born To Ride, the timbre of his voice and the way it sounds like he has just been asked to do a chore, is a perfect microcosm of Goosebumpss 28 minutes.
Its been years since Ive had this hard of a time listening to an album all the way through. It tempers the charms (such as they are) of the genre (such as it is)s poppier side with ill-conceived experimental ideas, and vice versa. Its tough to imagine a blander or less subversive album, in any genre, being given a release this high-profile in 2013. For example, its impossible to rap without at least some character coming through. All types of otherwise-terrible pop songs are prone to getting stuck in ones head. Bad noise is the funniest type of music there is. The bottom of the indie rock barrel, on the other hand, is unique; it offers nothing. For all its blandness, though, Goosebumps is awfully inconsiderate towards its listeners, both on a purely sonic level and by tacitly assuming that people will listen to anything if one of the guys is wearing a brightly-colored baseball cap and the group signifies weed somehow.
By Joe Bernardi


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Botswana Prices
Traditionally, Botswana is one of the more expensive lodge safari destinations in Africa. Many of the best safari regions and private concessions can only be visited on a 'fly-in' basis, and tourist numbers are strictly limited. This results in a highly exclusive, but consequently expensive, safari destination.
If you are on a limited budget, it is possible to explore many of the public reserves and parks by self-drive vehicle, or by joining a group camping trip, but invariably you'll lose out on the exclusivity for which the country is renowned.
Prices vary considerably due to the season of travel. July to October is generally considered high season, with April to June and November as the shoulder season, and December to March as the low/green season. Typically, a tailor-made two week 'fly-in' safari holiday, including economy class flights from the UK, will start at around £4500.00 per person in low season, though somewhere between £6000 and £10,000 per person is more typical in the shoulder and high seasons.
Combining a shorter Botswana safari with sight-seeing or beach destinations in other countries will reduce the price, depending on what is included, whilst more adventurous camping tours may start from around £3250.00 per person (including economy class flights from UK) for 10 days or so on safari.
We appreciate that going on safari in Africa is an expensive holiday, but we are always conscious of providing 'value for money'. Our selection of safari properties for any itinerary is based entirely upon those which we feel will most closely match your requirements, whether that be budget driven or experience driven. It is sometimes very difficult to differentiate between a top-quality safari property, and one which offers a lesser experience. Accordingly, a safari which offers value for money should not necessarily be confused with a 'cheap' safari.
If you are planning your first safari, we suggest you look at our Planning a Safari section.


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It is not because you know nothing about technology, and for some reason sound proud of it, that you should let your business be run by geeks. As much as they can be nice and helpful, geeks only know how to communicate with two entities: computers and other geeks. You are just an annoying, albeit … Read More →


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Will I accumulate much study delay if I study abroad?
A period of study abroad usually fits into the space reserved for optional electives within your study programme. This means you need not accumulate any study delay.
It's important to check in advance, with your study advisor, that the courses you intend following abroad fit well into your programme of studies.
More information
- Categories
- Your study
- Get more out of your study time


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WINNIE THE POOH 9" Plush Toy
Buy it now at:
This super-soft 9" Winnie the Pooh plush toy, made from 100% polyester, is perfect for snuggling and sweet hunny dreams! He features a jingle in his rumbly tumbly and crinkle in his ears to keep baby giggling. Made by Kids Preferred.
Disney Baby is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to amazon.com.
- Made By: Kids Preferred
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Frequent Links
|Classification and external resources
|Patient UK
Arteriolosclerosis is a form of cardiovascular disease affecting the small arteries and arterioles.
Types include hyaline arteriolosclerosis and hyperplastic arteriolosclerosis,[1] both associated with vessel wall thickening and luminal narrowing that may cause downstream ischemic injury. Arteriolosclerosis is most often associated with hypertension and/or diabetes mellitus.[2]
The following terms are similar, yet distinct, in both spelling and meaning, and can be easily confused: arteriosclerosis, arteriolosclerosis, and atherosclerosis. Arteriosclerosis is a general term describing any hardening (and loss of elasticity) of medium or large arteries (from the Greek arteria, meaning artery, and sclerosis, meaning hardening); arteriolosclerosis is any hardening (and loss of elasticity) of arterioles (small arteries); atherosclerosis is a hardening of an artery specifically due to an atheromatous plaque. The term atherogenic is used for substances or processes that cause atherosclerosis.
- ↑ "Arteriolosclerosis" at Dorland's Medical Dictionary
- ↑ Robbins, Stanley L.; Kumar, Vinay (2007). Robbins basic pathology. Saunders/Elsevier. p. 343. ISBN 0-8089-2366-8.


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text: Contents Now Platform Capabilities Previous Topic Next Topic Rollback To behavior ... SAVE AS PDF Selected Topic Topic & Subtopics All Topics in Contents Other Share Rollback To behavior The Rollback To activity transitions directly to the activity specified by the transition line arrow. Use the Rollback To activity for all workflows that use multiple or nested rollbacks. Rollback To resets the targeted task (the direct transition) to Open. All tasks that have executed between the Rollback To activity and the targeted task (rolled back task) are set to Pending. (0) Begin (1) Log Message (2) Task 1 (3) Task 3 (4) Task 2 (5) Timer (6) Approval 1 (7) Roll back to first task (8) Task 1 (9) Task 2 (10) Approval 1 (11) Log approval (12) Join (14) Send email (15) End Figure 1. Rollback to workflow Transition history The state of (3) Task 3 does not change, since this activity does not directly transition from the rollback target activity. To see what activities were rolled back, select the Workflow Transition History related list and look at the Rolled back column. The Rollback To activity (7) updates the following activities: (8) Task 1: reset to Open (9) Task 2: reset to Pending (10) Approval 1: reset to Not Yet Requested Figure 2. Rollback To workflow transition On this page Send Feedback Previous Topic Next Topic


text: CPLO Briefing Paper 363 : Labour and Asylum – Regional approaches to migration Date Published: November 3, 2014 1:12 pm Published by: Mayibuye Magwaza Tags: Asylum Seeker Border Crossing briefing paper economic migrants undocumented migration Download the full briefing paper. Introduction All over the world, millions of people continue to move from one region to another, seeking sanctuary from violence and poverty. Almost monthly, a fresh horror emerges from the waters around southern Europe, where thousands of people risk the voyage from North Africa in leaky, unseaworthy boats. In one such incident in September 2014 approximately 500 migrants died when their boat sank near Malta. According to initial reports, traffickers deliberately sank the boat after the passengers refused to move to a smaller craft. Within Africa, refugees continue to travel across borders in search of a safer life. However, in the broader international context the civil war in Syria has sent millions fleeing to neighbouring countries. This is putting a massive strain on the resources of international organizations that aid refugees, and limiting what they can accomplish within the continent. Tags: Asylum SeekerBorder Crossingbriefing papereconomic migrantsundocumented migration Categorised in: Review


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Nearly 80 trainees are being sought to drive Britain's newest express trains, Virgin Trains East Coast (Vtec) announced today.
The 78 drivers will earn more than £57,000 when qualified.
They are required for the operator's new Azuma fleet, which is to run between Scotland and London from 2018.
Virgin said a "significant" number would be based in Scotland, with Edinburgh one of five recruiting centres.
It will be the first time new drivers have been recruited for the route since before British Rail was privatised in the 1980s.
The influx will increase driver total of 346 at Vtec - which is 90 per cent Stagecoach owned - by nearly a quarter.
They are needed because the fleet of 65 new trains will operate more frequent services between King's Cross and Edinburgh, some of which run on to and from Aberdeen, Inverness and Glasgow.
A flood of applications is likely after ScotRail was inundated with an "unprecedented" 22,000 responses when it advertised 100 jobs last autumn.
Train drivers' union Aslef said qualified Vtec drivers earned £56,967.
This is expected to increase to more than £58,000 if a 2.33 per cent pay increase is agreed.
An Aslef spokesman said: "We welcome the fact that East Coast is finally recruiting and training their own drivers - for the first time since privatisation."
Budding drivers must be over 21 and have until next Friday to apply.
Vtec People director Clare Burles said: "It doesn't matter if you have never worked in rail or if you haven't even considered a career as a train driver before - we are looking for people who are not afraid to do things a little differently and want to be part of something innovative and rewarding."


text: Daisy Jazz Isobel Ridley is an English actress. That is best known for her performance in Star Wars: Episode VII - The Force Awakens. She has won awards for Breakthrough Performance of the Year at the Golden Schmoes Awards (2015); Best Female Newcomer at the Empire Awards, UK (2016); and for her Breakthrough Performance at the MTV Movie Awards (2016).


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All Princess Movies
Beauty and the Beast
After the beautiful Belle is imprisoned in an enchanted castle by a Beast, she discovers the kind and gentle prince within.
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Snow White and the Seven Dwarfs
When the Magic Mirror proclaims Snow White as the fairest one of all, she flees into the forest and befriends the lovable seven dwarfs!
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Sleeping Beauty
When Aurora falls into Maleficent's grasp, it is up to Prince Phillip and the Good Fairies to save her from an evil spell.
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Pocahontas, daughter of a Native American tribe chief, falls in love with an English soldier as colonists invade 17th century Virginia.
See More
More Princess Movies
Beauty and the Beast: The Enchanted Christmas
Visit a Beauty and the Beast Christmas past, when Belle does her best to warm the Beast's castle with the spirit of the season.
See More
Aladdin: The Return of Jafar
When the evil Jafar escapes from the magic lamp as an all-powerful genie, it's up to Aladdin, Jasmine and Genie - to save the kingdom.
See More
Aladdin and the King of Thieves
Aladdin and his friends face terrifying threats and make some exciting last-minute escapes as they pursue the King Of Thieves.
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Pocahontas II: Journey to a New World
Pocahontas and her friends find adventure at home and abroad in these sweeping stories from the earliest days of American history.
See More


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About Us
Sunhawk Mod Services, Int'l (SMS, Int'l) is the leading provider of on-demand information technology services and software to individuals and businesses over the Internet. [Online since 2005]
SMS, Int'l provides instant access to software and files on any Internet-enabled
device, at any time, anywhere in the world. It also enables
customers to use software from multiple vendors and purchase secure, on-demand computer capacity
on a price quote basis at a fraction of the cost of purchasing
and supporting premise-based solutions or products. SMS, Int'l is designed for a "closer experience" with
our clients and is designed to deliver computing services and applications. The company has established a
strong position as the leading provider of on-demand software services to
small and mid-sized tech businesses as well.


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All student appointments can be made online through Handshake. Request a CPD coaching appointment by clicking on the "Appointments" tab on the left navigation panel, then "Schedule a New Appointment".
Branden Grimmett
Associate Provost
Phone: 310.258.8779
Campus Partners: LGBT Student Services; Muslim Student Life; William H. Hannon Library
Branden joined Loyola Marymount University as Associate Provost for Career and Professional Development in June 2015, where he leads the university's Career and Professional Development initiative. In this role he oversees the office responsible for successfully launching undergraduate and graduate students into their professional careers. Over 97% of LMU graduates are employed, enrolled in graduate school, or pursuing post-graduate service or military within six months of graduation. Before joining LMU, Branden held similar leadership roles in career services at St. Olaf College, Tufts University, and Harvard University. His work in the field of career services has been featured in The New York Times, USA Today, the Wall Street Journal, the Education Advisory Board, and the book Will College Pay Off? by Peter Cappelli of the Wharton School of Business. (Full Bio)
Carolynn Grainger
Director of Industry Partnerships
Phone: 310.338.1737
Campus Partners: Student Psychological Services; Study Abroad
Carolynn brings to her role as Director of Industry Partnerships a strong background in higher education, having worked at three distinct universities. In her current role she works with employers, alumni, and students to facilitate recruitment efforts on campus and build community partnerships throughout greater Los Angeles. Previously she worked supporting various LMU boards and councils, the Board of Trustees at Simmons College, and recent graduates at UConn's Medical and Dental Schools, all of which gave her a rich understanding of the needs of successful alumni. Her undergraduate studies focused on communication and anthropology, and most recently she joined the Lion community by earning her M.Ed. at LMU.
Marcy Newman
Director of Campus Partnerships
Phone: 310.338.5888
Career Coaching Focus: Communications & Media
School Liaison: College of Communication & Fine Arts
Campus Partners: Academic Resource Center; ASLMU; Greek Life; Jewish Student Life;
Marcy joined Loyola Marymount University and CPD in September 2015, and works with students, faculty and staff to cultivate campus partnerships to support students' career and professional development. Marcy's past roles include working in Alumni Relations at Cal State Northridge, and most recently, at Mount Saint Mary's University as an adjunct faculty member teaching career courses as well as the Associate Director of Career Services & Internships. Marcy holds an M.Ed. in postsecondary administration and student affairs from the University of Southern California and a B.A. in communication studies from Cal State Northridge.
Kyle Greenberg
Director of Professional Development & Pre-Law Advisor
Phone: 310.338.2892
Career Coaching Focus: Government & Public Policy; Legal Professions & Criminal Justice; Post-Graduate Service; Sports Management & Recreation; Undecided
School Liaison: Bellarmine College of Liberal Arts
Campus Partners: Office of International Students & Scholars (OISS); Pre-Law; Student Employment Services, Student Worker Program
Kyle works closely with the staff and faculty of the Bellarmine College of Liberal Arts to deliver innovative, customized, and engaging programs and services to the students of 47 different majors and minors. With years of public speaking experience—from hosting weekly college events with 1,300+ students in attendance, to coordinating town hall meetings with the City of Los Angeles — Kyle frequently facilitates workshops on translating major to career, effective networking strategies, and cutting edge resume and cover letter writing techniques. Kyle holds an M.S. in college counseling and student development and a B.A. in communication studies from Azusa Pacific University. He is also a Certified Federal Job Search Trainer and Federal Career Coach.
Dr. Hannah Bateman
Associate Director, Graduate Programs and Education Professions
Phone: 310.338.8772
Career Coaching Focus: Education, Non-Profit and Social Service, Undecided
School Liaison: School of Education
Campus Partners: First to Go Community; GSLMU; Guardian Scholars Program
Hannah joined Career and Professional Development (CPD) in February 2017. She is responsible for developing and providing career services and programming for all LMU graduate students. She is also the official liaison for the School of Education and provides career coaching to undergraduate students interested in pursuing a career in education. Dr. Bateman joins us with over seven years of experience in higher education. Most recently, she was the Human Resources Manager for UCLA's HR and Payroll Administration South department. Prior to that position, Dr. Bateman worked at the UCLA Career Center as the Career Resource Specialist for the Bruin Guardian Scholars, UCLA students who are current and former foster youth. She also previously held a position at Georgia Institute of Technology where she facilitated summer internship placements for teachers and students. Dr. Bateman earned both a Doctorate of Education and Master of Arts in Education from Pepperdine University and a Bachelor of Arts in English from Clark Atlanta University. She looks forward to engaging with students and supporting them on their career paths.
Liz Connolly
Assistant Director of Alumni Engagement and Liberal Arts
Phone: 310.338.3745
Career Coaching Focus: Government & Public Policy, Nonprofit & Social Services, Post-Graduate service, Undecided
School Liaison: Bellarmine College of Liberal Arts
Campus Partners: Campus Ministry; Student Organizations; University Honors Program
Liz joined Loyola Marymount University and CPD in November 2017, working with staff and faculty from Bellarmine College of Liberal Arts and Alumni Relations to deliver career programs and services to both students and alumni. With a background in student counseling and alumni relations, Liz is passionate about engaging the LMU alumni community in the professional development of current students, as well as providing opportunities for students and alumni to grow and utilize their LMU network. Liz holds an Ed.M. in Higher Education from the Harvard Graduate School of Education and a B.A. in Political Science from UCLA. Born and raised in greater Los Angeles, Liz visited the LMU campus many times with her family. She is excited to now officially be a part of the Lion family!
Erica Privott
Assistant Director, Engineering, Science & Technology Professions
Phone: 310.338.6006
Career Coaching Focus: Computer Science & Technology; Energy & Environment; Engineering; Science & Lab Research; Undecided
School Liaison: Frank R. Seaver College of Science and Engineering
Campus Partners: Center for Service and Action; Student Housing; Undergraduate Research Opportunities Program (UROP)
Erica joined Loyola Marymount University and CPD in April 2017, working closely with students and faculty from the Seaver College of Science and Engineering. Facilitating engaging and diverse career development workshops and trainings, she encourages her students to focus on their accomplishments, get involved on and off campus, and build and utilize their network to create opportunities. Her career journey encompasses recruitment, STEM education and outreach, event and conference planning, and most recently internships and job placement at a private liberals arts institution. A native of the D.C. Metropolitan area, she is passionate about diversity and social justice, empowering emerging leaders, and serving her community. Erica is pursuing a Master of Arts in Higher Education Leadership from LMU. She currently holds a Bachelor of Arts in Business Administration from Thiel College.
Gregory James
Assistant Director, Health Professions
Phone: 310.338.5942
Career Coaching Focus: Healthcare & Medicine; Alternative Healthcare; Pre-Med; Energy & Environment; Computer Science & Technology; Engineering; Science & Lab Research; Undecided
LMU Liaison: Center for Student Success (Seaver)
Campus Partners: Academic Community of Excellence (ACE); Athletics; The Learning Community (TLC)
Gregory joined Career and Professional Development at LMU in February of 2016, after visiting campus many times as a health graduate program recruiter with Western University of Health Sciences. His many years in recruiting and program development inform his work with students, and Gregory is well-versed in diverse health professions and industries related to medicine. Gregory holds an M.S. in Leadership and Management from the University of La Verne, where he focused on human resources management and organizational development, and a B.A. in Film Studies from the University of Nevada, Las Vegas. Gregory is an avid basketball (Los Angeles Lakers) and football (Minnesota Vikings) fan, and is excited to support students in his role at LMU.
Angelina Lee
Assistant Director, Business Professions
Phone: 310.338.3959
Career Coaching Focus: Accounting & Finance; Entrepreneurship; Management, Consulting & Human Resources; Marketing & Sales; Undecided
School Liaison: College of Business Administration
Campus Partners: Disability Support Services; Transfer Programs; Veteran Programs
Angelina is the newest addition to the CPD team, and joined Loyola Marymount University as the Assistant Director of Business Professions in August 2018. She brings career development, employer and alumni engagement, student and faculty support experience from her previous role at Otis College of Art and Design nearby. Angelina has also worked in human resources, finance, operations, and international marketing in the non-profit and corporate sectors. She is passionate about social justice, POC and WOC representation, and BAM (business with a mission). Angelina holds a M.A. in Christian Ministry & Leadership from Biola University, and a B.A. in Political Science/International Relations from U.C. San Diego. She is multilingual in Mandarin Chinese, Korean, and French, and loves to travel around the world. She is excited to serve the LMU Lions community!
Elena Muslar '11
Assistant Director, Entertainment & Fine Arts Professions
Phone: 310.338.1715
Career Coaching Focus: Fine Arts and Performing Arts; Entertainment and Media; Undecided
School Liaison: College of Communication & Fine Arts and School of Film & Television
Campus Partners: LMU Student Media; Mane Entertainment; Del Rey Players; KXLU; and EIS (Ethnic & Intercultural Services: Asian Pacific Student Services; Black Student Services; Chicano Latino Student Services).
Elena returned to LMU in March 2017 as the Assistant Director for Entertainment and Fine Arts Professions in Career and Professional Development. She is a proud undergraduate alum and excited to be back on campus as a resource for fellow lions interested in creative careers. She has held positions in various organizations garnering her years of experience in arts administration, creative producing, and cultural engagement. Dedicated to helping develop the next generation of emerging arts leaders, Elena has a vested interest in the relationships between arts enterprise, social justice, and creative entrepreneurship. Elena obtained her M.F.A in Theatre Management specializing in Producing from CalArts and B.A. in Theatre Arts with minors in Dance and African-American Studies from LMU. During her formative years on campus, she was also a member of Belles Service Organization and loved being an LMU Tour Guide.
Kelley Stewart
Operations Manager
Phone: 310.338.2997
Kelley joined Career and Professional Development in November 2014. She provides daily supervision of the administrative and student staff, as well as ensuring the smooth day to day operations of the CPD office. Kelley has over 10 years of professional experience, and has held administrative positions in various fields including Development, Alumni Relations and Event Management. She holds a B.A. in communication studies from California State University, Long Beach.
Brandon Earle
Communication and Event Coordinator
Phone: 310.338.5152
Brandon became a member of the Career and Professional Development team in January 2017. In his role, Brandon manages social media, oversees event coordination, and also creates marketing content for CPD initiatives. His background includes years of event management experience where he has managed conferences and expositions across the United States. Brandon was born and raised in the Washington, D.C. metropolitan area and spends much of his leisure time cheering on all of his local sports teams. He is currently enrolled in the Master of Communication Management program at USC and holds a B.A. in Sociology with a minor in Economics from Howard University.
Norma Gochez
Phone: 310.338.2871
Norma Gochez provides administrative and office support to Career and Professional Development. With more than 15 years of experience, she greatly enjoys welcoming students and alumni for their individual appointments with a Career Coach or with our expert peer advisors. She loves being a part of such a committed and professional department at LMU. Norma, a licensed esthetician, enjoys, in her personal time, inviting friends over for facials and especially to meet her beautiful and chatty parrot, Lorenza.
Poulomi Chatterjee
Applications Systems Analyst - ITS/CPD
Phone: 310.338.3076
Poulomi joined Loyola Marymount University in October 2016. She is an Application Systems Analyst and reports to Information Technology Services, while servicing Career and Professional Development. In her current role, she primarily works with CPD as their technical support and ensures all technology systems function in support of consistent service delivery and business processes. She collaborates with multiple university departments and external vendors (i.e. CSM Symplicity, Banner, and Handshake) to develop and implement technology initiatives for CPD. She manages the execution of information technology strategic plan for CPD in support of new technology that is integrated into existing suite of career related services, programs, and resources. Previously Poulomi has worked as a Software Tester/Business Analyst in .Net framework for Kaihatsu Techno Center in India. Poulomi holds a Bachelor's Degree in Engineering in Information Technology from Mumbai University in India and very recently joined the Lion Community by earning her Master of Science in Systems Engineering from LMU.


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David Benson
- List.co.uk
- 8 August 2006
This article is from 2006.
Fusing the camp and the sophisticated, David Benson exudes a natural charm during the songs he performs with Dean Martin-style cool, and the anecdotes that interlink them. The latter occasionally threaten to enter self-indulgence but are saved by relaxed wit and the fact that he swaps his bank manager jacket for a sequined one for the final number. (Emma Newlands)
Pleasance Courtyard, 556 6550, until 28 Aug (not 16), 2pm, £7.50-£8.50 (£6-£7).


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FC: Life Isn't Worth Livin' Without Julie
1: I mis screamin at this guy..haha | asian power!!!! we rock,we korean...hmmm
2: akkkkarkrkakrkakrakrakkkk,,,hahaahhahahhh nanamoye, khady, et moi... | hehe we rock! courtney u loser, you have ur eyes closed!!!
3: IF I HAD ONE WISH~ WE WULD BE BESTFRIENDS, LOVE WULD NEVER END, IT WULD JUST BEGIN. IF I HAD ONE WISH~ YOU WULD BE MY BOO, PROMISE TO LOVE YOU, TRUST ME ILL TRUST YOU... | me n my maria | awwww claude n meeeee awwwwwwwwwwwwwww | my darlllwings
4: c moi et crapbag..hahaaaa | oh boi do i miss senegal..haha ;[:[ | Arnold and mE! gosh, look at that lips, its super huuuge! | my prettyboy and me | me n sagar..hehaho
6: O.K we have 10 seconds... RUUUN and SMILLEEE
7: I SPY with my little asian eyes: a super flashy bra.. | we made pancakes, funfun too hahahaha
8: me n the other freshmen gals. ill surly miss them too | me and my mistress, mariellaleleealalalallalaeelalealela | aggain..@@@ *look at mandlas face..ahhhhkakarkakrkaakrkakrka* | we played pool! much much funnn!
9: aiii i love abduls face here.. its sooo you..haha WOOOOOOOOOOOOOOT? | heheheee i love this picture, ELIMS tout le monde!
10: me and my baby | hmmm wat were we doing..?
11: woooot | we love our gonc(z)alo!!! and his dad..hehe :];] riite?? | my little crapbag
12: me n christinneeee | me n my loove
13: popo n juju.. wit ricardo as a background..hahaaa | surroundered by my lavely blondiess
14: smilleeeee
15: we Pose yeee | smillleeeee | me n bechir,,hehee
16: Azizzz wit mee
17: We have awsome time at lunch!!! we jazz, we rock, we cool


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text:
I made this baby back in January. I was going to New York for the first time to visit with 2 friends who moved back east. We were going to have a girls weekend in the city and see Mamma Mia!
Wearing my dress to work today and rocking these awesome tights! Sorry for the messy room, we're doing a lot of household rearranging.
I'm a San Diego girl and my idea of "winter" is not real winter. But be damned if I was going to be under dressed at a play! So I whipped up this dress. And when I say I whipped it up, I mean whipped it up. The night before I was supposed to go to New York, I sewed most of the dress (instead of packing) while hanging out with the neighbors who came over. Then, the next morning I got up and packed, hemmed my dress, and brought a needle and thread with me and hand basted the collar at my friend's house the night before the play.
But lucky for me this was seriously the easiest dress I ever made!
Here I am on the right wearing my dress in Times Square before Mamma Mia (under a coat, scarf, and hat, and over tights, leggings, socks, boots, and a long sleeve T shirt):
And now a word about the pattern (Butterick 5523)...
This was my first knit garment. I was unreasonably afraid of knits for a long time. I don't know why, this was insanely easy. I followed the pattern, except I found the waist elastic to be unnecessary (and I was in a rush!). I also left off the tab detail on the back. Ironically, that's what drew me to this pattern, but mine wasn't coming out right and I decided I didn't care.
In the meantime I'm in the cutting stages of my Pendrell blouse. I hate cutting out patterns. I have a vintage pattern from the 70s that's precut. I guess that's the advantage of buying one size. Cutting is just so tedious and has no gratification! But I have a 3 day weekend this weekend and with any luck I'll be sharing finished pictures soon!


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By Dan Weil |
Monday, 22 June 2009 10:38 AM
Swiss banks UBS and Credit Suisse may soon be cut down to size.
Swiss National Bank, the nation's central bank, says it may force shrinkage upon the banks to curb their risks, unless policymakers around the world figure out a better way to deal with bank failures.
"There can be no more taboos, given our experiences of the last two years," Philipp Hildebrand, vice-chairman of the Swiss National Bank, tells the Financial Times.
"There are advantages to size ... (But) in the case of the large international banks, the empirical evidence would seem to suggest that these institutions have long exceeded the size needed to make full use of these advantages."
The institutions have grown in recent years, to the point that they matched their biggest New York and London competitors.
Of course the Swiss banks also suffered big-time from holding toxic assets during the financial meltdown, just like their U.S. and European brethren.
UBS and Credit Suisse suffered billions of dollars of losses during the financial crisis, and last year their collective assets were equivalent to six times Swiss GDP. So the government has reason to be worried.
In the United States, meanwhile, the Obama administration's financial regulation proposal does little to offset the too-big-to-fail problem, experts say.
"The Obama plan is little more than an attempt to stick some new regulatory fingers into a very leaky financial dam rather than rebuild the dam itself," Joe Nocera writes in The New York Times.
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DisclaimerThe opinions expressed herein are my own personal opinions and do not represent the view of anyone else, in anyway.
© Copyright 2018
We were hit with a sudden cold snap, which meant even this most reluctant gardener had to face up to the fact that her salad days were numbered.
A few snips of the scissors and two garbage bags later, the chard was in hand. Giant bouquets of it, requiring washing, stemming, chopping and blanching.
Remarkable how those leathery, luxuriant greens simmered down to just seven servings. Seriously. It took all morning to prepare seven chard balls for the freezer.
That Pioneer Woman's got nothing on me. Except her own show on the Food Network.
The killing freeze came and went and what little chard remains gardenside is thriving, it's hearty fronds stretching toward the sun. The next gleaning will be with a flame thrower.
(For a less snarky take on how to freeze chard, visit this nice lady for her take.)
Of course, this is only a fraction of what our tree produces. But aren't they stunning? I love their wabi-sabiness, the scratches and dents and insults perpetrated by squirrels and worms alike. And the color.
Nature does it up right.
We enjoyed a lovely apple cake last night, recipe courtesy of Mama Elaine. I back off on the sugar a bit, 1.25 cups instead of two and split the flour between all-purpose and whole wheat. And use more apples, for obvious reasons.
L'shanah tovah, a happy and healthy and sweet New Year to all our friends and loved ones!
Gardens, we're discovering, aren't linear, preditable things. One year the tomatoes are so prolific, you can't manage the marinara production. Another, broccoli abounds to the point you're giving it to the neighbors in bouquets. This year, it's greens. The kale. The chard. The arugula. All bitter and tangy and astringent, the greens are a forest of dark, swaying fronds so dense, the cats can hide and we're nary the wiser.
With some gift funds still available in my Amazon account and in my recumbent state, it's been easy to click "add to my cart" when something promises ideas for these things other than steam, plug your nose and chug.
Which is how this ended up on my doorstep. (There's recipes to be had if you click on the link...)
Spend a few minutes on Sara's site Sprouted Kitchen and you'll immediately notice the care and attention she gives the food and her readers. Glowing with her husband's evocative photography, Sprouted Kitchen serves up plate after plate of wholesome, mostly vegetarian dishes, heaping inspiration and simple goodness into every post.
Her book is exactly the same. A collaboration between she and her husband, Hugh, The Sprouted Kitchen is a dance between Sara's food and Hugh's images: Shot in extreme close-up, the Coconut Lime Tart coyly displays only a corner of the dessert, pistachio and coconut crumbs in delicious dishabille in the foreground. Or the Asian Tofu Tacos with Hoisin Slaw? You'll just want to crawl in between the folds of those whole-wheat torillas and bed down.
I'm up and about some at this point in my convalescence, and while curried tempeh leftovers were on tap for dinner, I snuck out the garden so as to try the Tuscan Kale Chopped Salad. Glistening with parmesan vinaigrette and punctuated with apples (our tree giveth and giveth) and dried cherries (in the pantry), the kale salad seemed just the thing (and so good for the eyes!). I whipped it, up eschewing the croutons in my tender state as well as the chickpeas, and substituted a tiny bit of raw garlic in the dressing for the shallots.
Hearty and packed with flavor, Mr. Nake-id must have eaten three platefuls.
We topped the meal off with Sara's Mango Mint Lassi using lemon as a stand-in for fresh orange juice, adoring its sweet, comforting coolness.
Yes, I'm smitten. Tonight we'll try the Honey Mustard Broccoli Salad, broccoli from the garden, and the Creamy Millet with Roasted Portobellos (topped with kale!)
So happily smitten.
Yesterday Mr. Nake-id and I put the garden to bed for the winter. For the past few weeks, Mr. Nake-id has been diligently pulling spent tomatoe plants and harvesting fruit before the coming snows. We had a bumper crop of green tomatoes, huge misshappen chartruese heirlooms and bright-green, bullet-shaped Romas: Their likely future, the compost bin. Steadily, though they've been ripening, enough so we enjoyed a hearty spaghetti dinner Saturday night and Purple Cherokees dressed in balsamic vinaigrette, Sunday.
The greens have been clear winners, especially the kale, which continues to unfurl curly leaves in the aftermath of two snowstorms. Our second planting of arugula and spinach remains pert and cheerful, too, in spite of the fact that it's only delivered one or two salads to the table.
There were some mistakes: The tomatillo I planted, thinking it was a zebra-striped tomato. It threw off dozens of charming paper lanterns with tiny, walnut-sized tomatillos contained therein; this made for a bitter, acidic salsa.
The crook-necked yellow squash turned out to be this thick-skinned, warty thing, more ornamental than edible. We foisted these aggressively on friends and family.
And, we planted, too many tomatoes, easy to do in Colorado, where our growing season is so short and the chance of slurping down vine-ripened fruit is slim. So we hedge our bets with quantity, thinking it will boost yield and instead create too much shade. Fresh tomatoes will do that to a person; they make you greedy.
Exasperated with the tomato crop at some point during the summer, I decided the fault was our dirt. Friends and professional gardeners have lauded this lasagna method for amending soil. Unfortunately adding layers of mulch and compost and manure to our garden would necessitate the removal of existing earth from our rock-rimmed bed; the very thought exhausted me. Then we heard this piece on NPR.
Being loathe to rake anyway in the hope the leaves will blow away over the winter (they never do), this technique of breaking down leaves to augment a lawn, struck us as a great way to nurture the farm. While Nake-id IT took on the easy job--breaking up the ground with a pick ax--I raked up piles of leaves, then shredded them with the push mower, or more accurately, moved them around a bit with the push mower, a tool not particularly well-suited for shredding. Mr. Nake-id then worked a couple of big leaf piles into the farm. And we bid the farm goodnight until spring.
The nest pictured in this post was invented and woven by Stephanie, a pratitioner of the lasagna gardening method and a happy Colorado gardener who grew baskets of ripe tomatoes. She weaves these lovelies from the leavings of sewing projects on a knitting loom. I love how mine looks in the crab apple tree; it's a hopeful beckoning image that reminds me of the hope and commitment to the future I felt in caring for our future garden, a reminder that spring and fall are the gaudy transitions between intropsection and expectation, and that life goes on.
How did your garden grow?
With the cucurbits coming in fast and furiously, I'm forced to bake--even in this heat. Since there is no turning the oven on after noon, I was at it early making our contribution to tonight's neighborhood dessert party: vegan chocolate zucchini bread. Bet they can't wait for us to show up.
I adapted the recipe from Hell Yeah It's Vegan, who adapted it from another source.
3 tbsp chia seeds whisked into ½ c + 1 tbsp warm water* ½ c oil (I used organic canola mixed with Wildtree butter-flavored grapeseed oil) ½ c applesauce 1 cup organic cane sugar 1 tsp vanilla 2½ cups grated zucchini, packed (~3 medium-sized zucchini) 1½ c all-purpose flour 1½ c whole wheat flour 1 tsp salt 1 tbsp baking soda 1 tsp baking powder 1 tbsp cinnamon 5 tbsp Dutch cocoa powder
1 cup vegan chocolate chips
½ cup chopped walnuts
Preheat oven to 350 degrees F. Grease two loaf pans.
Mix wet ingredients in one bowl, dry in another. Then combine, stirring until combined. Spoon into loaf pans.
Bake for 45-55 minutes. Revel in the scent eminating from the kitchen; is there anything better than the smell of baking chocolate and cinnamon?
*A note about chia seeds. Yes, these are the same chia seeds of chia pet fame. Packed with protein and Omega 3s, these little powerhouses are the new flax seeds. When mixed with water and other liquids, they create this viscous gel that acts as both a leavening and binding agent. (The natural food bloggers can't seem to get enough of this stuff as a pudding, but you gotta grok that slimy texture.) They're readily available at health food stores; in the Denver area, Sunflower Farmer's Market carries them in the bulk section.
Not everyone is bananas about raw kale (though the roly-poly bugs in the garden seem to be liking it just fine). Here at Chez Nake-id, we love the stuff. So when organic kale started selling for $3 a bunch, I got out the seed pack and started planting.
Kale is the gift that keeps on giving. While the arugala and spinach went all loose and dishabille in the heat, the kale has kept it togther, producing steadily for months. The kale pictured above is lacinato or dinosaur kale, so named, I imagined, because the store-bought leaves have the consistency of brontosaurus ears. Grow it yourself and you'll be dining on shoots as tender blades of grass; many days I simply run to the garden and pick my lunch.
Two weeks ago in Crestone, our hosts set out bowls of baked kale chips for their guests to snack on. Know what? You can't eat just one.
There are tons of recipes on the internets. You can tart these babies up with everything from lime and chili powder to paprika, parmesan cheese, nutritional yeast and fancy vinegars.
Here are the basics:
1 bunch (or two) of kale, lacinato or curly
1 Tbs olive oil
1 tsp good quality sea salt
2 pinches cayenne pepper, optional
Preheat oven to 300 degrees. Wash and dry your kale. Cut out the fibrous ribs (I didn't do this because *ahem* my kale is so tender) and roughly chop the kale.
Toss the leaves with olive oil, salt and cayenne and spread out in a single layer on baking sheets. (I used two very large sheets.)
Check for crispness after 20 minutes. Depending on how tightly you packed your kale on the baking sheets, you may need to bake a bit longer. You want them very crisp.
Serve them at your next do. They make for a great conversation starter.
We know what's for dinner this evening. And the next...and the next.
But thanks to Susan (Reflections of a Bad Catholic), winner of our Vegan What's-for-Dinner Contest, we also have Sweet and Crunchy Quinoa Salad and Three-Bean Salad with Olives to look forward to.
Thanks to all who played. Susan will receive two Vera Neumann dishtowels.
Now, what to do about Super Zuke? Zucchini boats? Zucchini air-craft carriers?
A couple of years ago, Sundari from Heirloom Gardens sold me some purslane along with other greens. It's an au currant vegetable, full of omega 3's and vitamin C. And, like she said, it's also probably growing in the cracks of your sidewalk.
I chopped it up and put it in a salad, and as we ate, I had that queasy feeling you get when eating something with questionable provenance--like chicken beak or eel roe. Or anything Andrew Zimmer ingests. So with a bumper crop of purslane invading inhabiting our garden, I thought, what if we could obviate its identity? Out came the food processor.
Take your favorite pesto recipe--for basil, sage or parsely--and substitute the leaves from these ubiquitious plants. I used two large weeds, a healthy handful of walnuts, one garlic clove, one lemon, sea salt and enough extra virgin olive oil to get the mixture to "pesto."
We spread it on homemade flatbreads and topped it with grilled vegetables. Lovely. Organic. And free!
N.B. After separating hundreds of purslane leaves from their stems, I've realized that no matter how satisfying it is to eat the enemy, there are more efficient weed mitigation strategies.
There's a bus to catch, so this will be brief:
My entire theory of gardening boils down to parsimony: Plant the stuff that's too expensive to buy organic in the market. Like arugula.
Last month the garden happily killed off a zucchini, three basil plants and stunted the tomatoes, putting us aboiut $25 in the hole, but the leafy greens and broccoli are thriving.
If you are similarly blessed, try this easy non-recipe with your arugula of lemon, olive oil and your very best salt. So good you'll be tempted to spring for the greens in the super market.
Here's the thing: One day you have no sprouts, the next day you have so many that you're going, "Here, kitty, kitty...nom, nom!"
Having gone all vegan, I've read that living foods--sprouts--are particularly beneficial. (Though once they hit the hydrochloric acid swirling around in your tummy, no doubt, all bets are off as far as health benefits.) So I ran off to my favorite source for all things herbaceous (Mountain Rose Herbs) and loaded up on sprouting seeds and a hemp sprouting bag, developed by a guy who calls himself, Sproutman. I'll just leave it there. Sproutman.
It's all very easy. You water them. Drain them. Keep them in the dark for a time. Give 'em a dose of sunlight, pumping them up with chlorophyll and before you know it you have...food.
The germinating seeds pictured above in the little bag are radish sprouts, the ones in the jar are red clover. What in the world are we going to do with them?
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Fullsize Titflash Display
RIGirl's Age: 42 - 48 years
Submitted from: United States
Titflash Photo ID: 107124
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Mmmmmm:I want to fuck those beautiful tits all night long and glaze them with cum so they look like frosted Christmas cookies
December 22, 2011, 11:08 pm
GORGEOUS:Wish you were going to be under my tree!!
Honey you have some AWESOME breasts that would be a joy to caress and kiss!!
December 22, 2011, 9:06 am
Thank you..:):
December 22, 2011, 8:26 am
RIG:Once again you got my attention and have me wondering what is she wearing below the camera lens...Well its the season for giving..You give me a peek and I'll give you a peek
December 22, 2011, 8:11 am
Rigirl:Just a suggestion hun :)
December 22, 2011, 8:05 am
Rigirl:Instead of pulling up the sweater, unzip it :)
December 22, 2011, 8:00 am
Sweaters with zippers:I love sweaters with zippers. ;-) Beautiful!
December 22, 2011, 7:59 am
That seems to be a popular sweater, just like these tits! Thanks RI and Merry Christmas!
Rigirl:Oh how ive missed you...merry christmas to you hunny!
December 22, 2011, 7:58 am
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Increasing functional versatility of proteins by regulated unfolding and exposing disordered regions
Proteins are the fundamental executor molecules of living cells. They are polymers of amino acids and their functioning is tightly linked with their structure, i.e. the precise positioning of atoms. Recently, it has been shown that proteins may remain unstructured/disordered and yet be functional. More excitingly, certain proteins can interconvert between different folded structures and undergo a change between folded and unstructured conformations in a controlled and reversible manner (Regulated Unfolding; RU). In certain cases whole protein domains unfold as a result of minor chemical modifications, so called post-translational modifications (PTMs), exposing cryptic disordered segments affecting both protein cellular localization and interactions. Thus a fundamental open question is how prevalent is regulated unfolding and what are the underlying molecular principles?
We hypothesize that RU is widely prevalent, because by conditionally exposing disordered regions hosting short linear interaction motifs (SLiMs) reversible conformational changes could alter the cellular localization and interactions of proteins and provide increased functional plasticity during conditions such as stress. The reason why RU remained understudied so far is most probably the lack of structural information for modified proteins.
We develop and apply an inter-disciplinary computational and experimental approach involving the targeted discovery and characterization of proteins undergoing RU to elucidate the prevalence and biological relevance. Introducing regulated unfolding as a novel layer of protein function regulation will lay the foundations of a novel concept in biology.