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Gladwell Insurance Blog: 12_2015
Gladwell Insurance Blog: 12_2015
View the latest blog posts from Gladwell Insurance.
Thursday, December 31, 2015
ERIE Donates $90,000 in Honor of 90th Anniversary
To help close out the yearlong celebration of Erie's 90th Anniversary, the company recently made a trio of donations totaling $90,000 to three deserving charities. The donations were part of a Legacy of Giving Contest that invited all ERIE employees to vote for one charity in their respective areas to receive $30,000.
Wednesday, December 23, 2015
Q&A: What to Know about Chip Cards
You're probably using your credit card a lot during the holiday season to pay for gifts. If so, you may have noticed a big change from previous year's cards. Today, many credit cards come equipped with chip technology that requires you to "dip" your card into a slot.
Saturday, December 19, 2015
Ask ERIE: Do I Need to Insure My New Engagement Ring?
There's no doubt that the holiday season is a popular time to get engaged. And that your new ring is beautiful and signals your newly engaged status. But did you ever consider what you would do if the ring was stolen, lost or damaged? See more
Wednesday, December 16, 2015
Preventing Christmas Tree Fires
For generations of children, it's been the most obvious sign that the Christmas season is really, truly, finally, here: a tree, beautifully decorated, smack in the middle of the house. And, for generations of adults, getting and decorating the tree is one of the season's most familiar traditions.
Friday, December 11, 2015
Auto Safety Technology Shown to Save Lives
Auto safety technology like automatic braking, adaptive cruise control and more has come a long way over the past few years. And that's a good thing, because recent research by the Boston Consulting Group shows that driver-assist systems have the potential to reduce U.S. road fatalities by 10,000 each year.
Wednesday, December 9, 2015
Putting a Price on the 12 Days of Christmas
Ever wonder what the actual cost is for some of the unique gifts in the classic "12 Days of Christmas" carol? Seriously, how much could a partridge in a pear tree really cost? Well, this year, it's $214.99. And those seven swans? Yeah, um, that'll set you back $13,125, according to the PNC Christmas Price Index®.
Friday, December 4, 2015
How to Organize Your Important Paperwork, Once and For All
Editor's note: Navigating your finances, not to mention your life, in your 20's can feel overwhelming… but it doesn't have to be. Follow our blogger Abby as she figures it all out in her new series "Adulting: I Can't Even… and So Can You!
Thursday, December 3, 2015
What Road Salt Does to Your Car
Winter is right around the corner. And with it comes difficult driving conditions like whiteouts and black ice. Road salt definitely helps makes the roads safer. A study conducted by Marquette University found that de-icing winter roads with salt reduces accidents by 88 percent and injuries by 85 percent.
Wednesday, December 2, 2015
The Best Holiday Tips from Erie Insurance
Though it may have seemed to start many weeks ago, the holiday season is now officially upon us. It's no doubt an exciting time of year in which a lot is going on. In between all the shopping, cooking and merry making, it's worth keeping a few tips in mind.
Blog Archive
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Best Outdoor Adventure in Every State
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7 things to do before you move homes
Wedding gone wrong? Insurance could help set things right
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Amazon's first no-checkout store is now open to the public. Would you miss standing in line to check
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Kidde Fire Extinguisher Recall
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Life's Little and BIG Surprises
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Facebook's 'Order Food' feature officially launches across the US
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Smart Homes 101: 3 Basic Components
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Car scratch removal made easy
Fall Premiere Dates For New & Returning Series: 2017 Edition
Equifax Hack -- How To Protect Your Credit And Identity If Your Data Was Compromised
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Don't neglect your savings!
See the most moving photo from the Cassini mission
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A Q&A with Life Insurance Awareness Month Spokesperson Danica Patrick
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How does your dog bring joy to your life?
7 Tips for a Successful Garage Sale
Go beyond the brown bag and get creative with these healthy school lunch ideas! https://goo.gl/WFwH9
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What's Coming to Netflix, Hulu and Amazon Prime in August 2017
How Safe is Your Deck?
Are you considering opening a restaurant? Make sure you're ready for the insurance considerations
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Protect Your Pets from Hot Cars
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Unintentional Drowning: Get the Facts
7 things to do before you move homes
All the Best Movies Coming to and Leaving Netflix in July 2017
How to Get Your Car Ready for Summer
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text: Secret Hotels2 Limited VAT case win - the implications 24 April 2014 0 comments Share A significant win at the Supreme Court could mean that travel companies may escape burdensome VAT costs. The dispute between Secret Hotels2 Limited (SH2L) and HMRC concerns whether SH2L was acting as an intermediary (agent) or in its own name (principal) when arranging hotel accommodation for its customers. If acting as principal, SH2L would be required to account for VAT under the Tour Operators Margin Scheme (TOMS). The case was originally heard in 2010, after HMRC's decision that the company acted as a principal and so was liable to pay VAT on its margin under TOMS. SH2L's challenge was dismissed by the First-Tier Tribunal. The company won its subsequent appeal at the Upper Tribunal, but that decision was reversed by the Court of Appeal in 2012. On 5 March 2014, the Supreme Court issued its ruling and found in favour of SH2L,which means that the company is not required to pay the £7.1m assessment issued by HMRC. The Supreme Court considered that the contracts between the hotel and the taxpayer, and the taxpayer and the end customer clearly identified that the room would be provided by the hotel to the end customer, with SH2L acting as an agent. The difference between the price charged to the customer and the amount paid by the taxpayer to the hotel was SH2L's commission for arranging the booking. Whilst SH2L and other travel intermediaries will clearly welcome the decision, hotels should ensure that they have correctly accounted for VAT on the full price of the room charged to a customer, rather than the amount actually received from an agent acting in the same way as SH2L. For advice on this matter, please contact a member of the VAT team. Contacts us Related links Hotels and hospitality VAT Hotels & leisureVAT

subset: commoncrawl


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Stitch Fix was actually one of my first subscription box services. I still love it, but I am both very picky about my clothing, and also happen to have a ton of clothes in general. So I now only receive a "fix" every other month. This review is of my January fix. (See my other Stitch Fix reviews here.)
For this month's fix I opted to be completely surprised. So I'm looking forward to seeing what my stylist has in store for me.
For those who have very sparse closets, this is definitely a service I recommend as it seems like Stitch Fix maintains quite an extensive collection of items. For the completely fashion-clueless, there are even style cards (see the picture to the left) that show you how to wear various items in each fix!


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What to do in Bodø
National Norwegian Aviation Museum – tells the story of Norwegian aviation history.
2017-02-27 17:08The Norwegian Aviation Museum is Norway's national aviation museum. The museum conveys an intimate experience of aviation and its fascinating history, with the help of impressive exhibitions spread across an area of approximately 10,000 m2.
Book your flight now! - Newton Flight Academy
2017-02-28 15:08We offer flight simulator sessions in two different levels: For beginners, and for advanced users.. Our full motion two seted simulators gives you the opportunity to fullfill your dream beeing a captain, and you are in full control of the aircraft from take off to landing. Our highly qualified instr


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Developed as a planetarium show, this video describes the unique environment of our solar system planets and a few satellites, along with some of the challenges and possible solutions for potential human habitation on each. Two versions of the video... (View More) are available through links on the site - a kids version (18 minutes, suitable for grades 2-5) and a more advanced version (22 minutes, designed for middle/high school). Both are applicable to school and/or general audiences. Information on purchasing the DVD's in both English and Spanish for large audience presentations is included. (View Less)
Materials Cost: Free
Learners will complete one or more poems about Saturn using descriptive words. As a pre-writing activity, students generate a word list from books they have heard and read and images they have seen and created. With the support of the word lists,... (View More) they will create poems. This is lesson 10 of 10 in "Reading, Writing & Rings!" for grades 1-2. (View Less)
In this lesson, learners will create an outdoor, to-scale model of the distances between the Sun, Earth, and Saturn. They will then conduct a guided walk to Saturn - which gives students an understanding of how far away Saturn is from Earth and the... (View More) Sun. Like enthusiastic travelers everywhere, students will write a "postcard home" to share their exciting trip. This is lesson 4 of 10 in "Reading, Writing & Rings!" for grades 1-2. (View Less)
Materials Cost: $1 - $5 per group of students
Learners will use drawing and writing to explore the comparative features of Saturn and Earth. To scaffold student writing, the lesson includes a drawing activity, a brainstorming activity, a structured Cloze activity, and a chance for independent... (View More) writing where students create their own analogies. This is lesson 6 of 10 in the Mission to Saturn Educators Guide, Reading Writing Rings, for grades 1-2. (View Less)


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Tadcaster's Jemima Browning was last month one of 20 young people worldwide awarded a Legacy Award from Princes William and Harry at St James' Palace – for her selfless commitment to transforming the lives of others.
Now Jemima, who set up the Tadcaster Stingrays swimming club for disabled young people like her brother Will, is championing National School Sport Week (NSSW) taking place this week 26-30 June and which marked the scheme with an inclusion-themed day yesterday.
Jemima said: "I am extremely passionate about disability sport and feel that everyone should have the same opportunities to take part and succeed.
"From personal experience I have seen how people sometimes struggle to see past a person's disability, as is the case with my brother.
"People don't see Will first, they see his Down's Syndrome and perceive he is 'different'. This has led to him often feeling excluded, isolated and unhappy."
Jemima was recently appointed to the prestigious Special Olympics Europe Inclusive Youth Activation Committee (iYAC) alongside Will.
Both have been commended for their work as part of the Play Unified campaign - run by Special Olympics GB and Youth Sport Trust - which aims to break down barriers for those with learning disabilities.
Jemima added: "Play Unified provides the opportunity to bring young people together and, by placing us with the direct responsibility to bring about change, we are able to create more opportunities for all of us.
"Opportunities we can all participate in, making new friends along the way both in and outside of school.
"I passionately believe that we all deserve the same opportunities and should treat each other the same, seeing past our perceived differences because when given a little extra support and opportunity, young people with ID (intellectual disabilities) can achieve anything they set their minds to, in the same way others can.
"I have set up an inclusive committee in my school with other students where we decide together what we can do in school to change attitudes towards people with ID and ensure that we organise activities that appeal to all of us, such as dance and team sports.
"Through this work, it has led to a truly memorable moment for me, with my brother and I representing Great Britain on the Special Olympics European Youth Committee; being the voice of young people across Europe and influencing international policy.
"At Tadcaster Grammar, this is having a positive impact. It is raising awareness of disability and challenging attitudes, promoting co-leadership, giving opportunities to succeed, improving self-esteem, reducing bullying, promoting inclusion and improving the school environment.
"It is a huge privilege to be part of this exciting initiative – shaping all of our futures, creating a unified generation and ensuring young people with disabilities are included."
NSSW is a huge celebration of everything that is great about PE and school sport. Organisers Youth Sport Trust invited all schools across the United Kingdom to take part.


text: Fanboy of "Be Mine" Kim Heenim(20). Sunggyu-ya.. Everytime you bowed 90 degrees, I wanted to climb on your back.. (6 hours ago) Sulli who always smiles even if she is lonely or sad. Sulli who still smiles even if I asked her if it was tiring to smile. Along with Tiffa Tiffa Tiffany(,) the two of them are happy viruses^-^ I am just a virus bbuing bbuingㅇㅅㅇ but why does instagram always cut off my pictures (7 hours ago)


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BioMed Research International
Volume 2013, Article ID 517698, 8 pages
Sanguinarine Inhibits Vascular Endothelial Growth Factor Release by Generation of Reactive Oxygen Species in MCF-7 Human Mammary Adenocarcinoma Cells
1Department of Clinical Pharmacology, Chinese PLA General Hospital, Beijing 100853, China
2Chinese PLA General Hospital, Beijing 100853, China
3College of Pharmacy, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
4College of Pharmacy, Bengbu Medical College, Bengbu 233030, China
Received 24 January 2013; Revised 29 March 2013; Accepted 12 April 2013
Academic Editor: Richard Tucker
Copyright © 2013 Xian-zhe Dong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The inhibitory action and the possible mechanism of anticancer compound Sanguinarine (SAN) on vascular endothelial growth factor (VEGF) in human mammary adenocarcinoma cells MCF-7 were evaluated in this study. We exposed MCF-7 to SAN for 24 h, then cell viability was assessed by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assay. Human VEGF was measured using a paired antibody quantitative ELISA kit, relative expression of VEGF mRNA was calculated using the real-time PCR studies, and the effect of SAN on the reactive oxygen species (ROS) level was detected by the flow cytometer. Treatment with SAN remarkably inhibited growth of MCF-7 cells and induced cell apoptosis. We found that VEGF release was stimulated by subtoxic concentrations of SAN and inhibited by high dose of SAN, SAN-evoked VEGF release was mimicked by low concentration of H2O2, and SAN-regulated VEGF inhibition was accompanied by increasing of ROS; these changes were abolished by antioxidant. High concentration of SAN inhibited VEGF mRNA expression in MCF-7 cultures, suggesting an effect at transcriptional level, and was also abolished by antioxidant. The present findings indicated that the regulation of VEGF expression and release from MCF-7 cells were possibly through reactive oxygen species evoked by SAN.
1. Introduction
Sanguinaria canadensis is a traditional herbal remedy which was produced in the eastern and southern provinces and the long-river basin of China used to treat fever and inflammation. SAN is an alkaloid obtained from the bloodroot plant Sanguinaria canadensis with the chemical constitution as Figure 1(a) and has beneficial effects on inflammatory disorders. Previous reports have demonstrated that SAN also exhibits anticancer properties. Extensive work over the past decade has shown that SAN can induce obvious cytotoxicity in many tumor cell lines, such as human colon cancer cells, oral squamous cell carcinoma cell line, prostate cancer cell, human osteosarcoma cells, and human gastric adenocarcinoma [1–6].
In our previous experiments, we determined the antitumors effect of SAN on a variety of tumor cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetra-zolium bromide (MTT) assay to investigate which cancer cell line was the most sensitive to SAN at the same condition. The cell lines were included Bel-7402 (human liver cancer), A549 (human lung cancer), HCT-8 and HT-29 (human colon carcinoma), BGC (human gastric cancer), LS180 (human colorectal), HeLa (human cervical), HepG2 (human hepatocellular carcinoma), EJ (human bladder cancer), SY5Y (human neuroblastoma), CNE (human nasopharyngeal carcinoma), and MCF-7 (human breast cancer). The results showed that MCF-7 cell line was the most sensitive cell line to the antitumor effect of SAN, the IC50 (50% inhibition concentration) of SAN was only 4 μM (Figure 1(b)). So the purpose of the present study was to clarify the related mechanism of SAN on human bladder cancer MCF-7 cells.
2. Methods
2.1. Cell Culture and Treatment
The human mammary adenocarcinoma MCF-7 was obtained from the Department of Obstetrics and Gynecology in Chinese PLA General Hospital and maintained in Dulbecco's Modified Eagle Medium (DMEM) supplemented with 10% FBS (heat inactivated at 56°C for 30 min) and 100 U/mL of penicillin and 100 U/mL streptomycin, in a 37°C incubator with a humidified, 5% CO2 atmosphere. Confluent MCF-7 cells were seeded into 96-well plates at a density of cells/well. After 24 h, the cells were exposed to various concentrations of SAN and incubated for 24 h. SAN was dissolved in dimethyl sulfoxide (DMSO) before added in cell. Final concentrations of DMSO were always less than 0.01%, which was proved to have no effects on cell viability. The absorbance was read at 570 nm with DMSO as the blank.
2.2. Cell Viability
The cell viability was determined by MTT assay. Briefly, 20 μL of MTT solution (2 mg/mL in PBS) was added to the culture medium at a final concentration of 0.5 mg·mL−1 and incubated at 37°C for 4 h. Then the supernatants were aspirated carefully, 150 μL of DMSO was added to each well to dissolve the reaction product of MTT, and the OD was spectrophotometrically measured at 570 nm, with DMSO as a blank. Viability was expressed as percentage of the values in vehicle-treated (basal) cultures, set to 100%.
2.3. Effect of SAN on Growth Curve
Cell growth curves were measured by the MTT assay. Cells were seeded into 96-well plates at a density of cells/well, treated with or without different concentrations of SAN, and then the cell viability at different time points was determined. The cell growth curves were drawn by the cell survival rates and the time points. The viability of each group at 0 h was supposed as "100%."
2.4. Flow Cytometric Detection of Apoptotic Cells
Cell apoptosis was measured using Annexin-V-FITC/PI apoptosis detection kit. cells were plated in 6-well plates per well. After treatment with SAN for 24 h, cells were harvested and washed in PBS, and then centrifuged at 1000 ×g for 5 min. The cell pellet was resuspended in the Annexin-V-FITC/PI labeling solution, mixed gently, and incubated for 15 min at room temperature in darkness. Cells were then analyzed in a Becton Dickinson flow cytometer (USA), and each sample collected ten thousand cells.
2.5. Intracellular ROS Quantification
The level of intracellular reactive oxygen species (ROS) was determined by the change of fluorescent probe dichlorofluorescein diacetate (DCFH-DA). Briefly, MCF-7 cells were cultured into 6-well plate and were treated with indicated concentrations of SAN (1, 2, 4, and 8 μM) for 24 h. Cells were trypsinized and washed with PBS, then incubated with 10 mM DCFH-DA for 30 min at 37°C. Subsequently, cells were washed twice with PBS and analyzed by flow cytometer. The protective effect of NAC was determined by adding 10 mM NAC or 20 kU/L SOD with SAN to the MCF-7 cells before the ROS measurement. Ten mM NAC or 20 kU/L SOD could inverse the inhibition effect of SAN on MCF-7 cell growth most significantly in the preliminary experiment.
2.6. Enzyme-Linked Immunosorbent Assay
Culture media were collected following treatments and promptly stored at −80°C until use in the assay [7]. Human VEGF was measured using commercially available ELISA kit purchased by Invitrogen according to the manufacturer's instructions. The assay sensitivities of VEGF were 5 pg·mL−1; data were expressed as pg·mL−1.
2.7. Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR)
Total RNA was extracted from cultured cells with Trizol (Gibco BRL) according to the manufacturer's instructions. cDNA was synthesized from 1 μg of purified RNA with random primer with the use of the First Strand Synthesis Kit (ReverTra Ace-a-, TOYOBO CO, JAPAN). Human β-actin and VEGF primer pairs used were synthesized by BM (Biomed, China) and described as follows. β-actin: forward 5-GGACATCCGCAAAGACCTGTA-3, reverse 5-ACATCTGCTGGAAGGTGG ACA-3; VEGF: forward 5-TTGCTGCTCTACCTCCAC-3, reverse 5-AAATGCTTTCTCCGCTCT-3. The PCR reaction was performed using the SYBR Green real-time PCR Master Mix (Toyobo, Japan) to detect abundance of PCR products among samples. The cycling conditions were, 50°C for 2 min and 95°C for 3 min, followed by 40 cycles of 95°C for 30 s, 60°C for 1 min, and 72°C for 30 s. VEGF gene normalized against β-actin which was chosen as an internal control and carried out from the same sample. Relative expression of VEGF mRNA was calculated using the comparative method [8]. All quantities were expressed as n-fold relative to the calibrator (control values which was defined as a value of "1.0").
2.8. Statistical Analysis
Values are expressed as mean ± S.D. Statistical analysis was done by using the SPSS 16.0 software. One-way analysis of variance (ANOVA) followed by Tukey's post hoc test was used for multigroup comparisons. Values of and were considered statistically significant.
3. Result
3.1. Effect of SAN on Cell Growth
From the growth curve (Figure 2), in the control group, cells were growing in normal form and speed; cellular proliferation was going into logarithmic phase after 18 hours from seeding in plates. After different concentrations of SAN treatment, the cells growth was suppressed significantly by time dependent and concentration dependent manner.
3.2. Effect of SAN on Cell Apoptosis
The staining assay was used to evaluate the apoptosis in MCF-7 cells. As shown in Figure 3, control cells without the treatment with SAN exhibited intact cell membrane (A). The cells, treated with SAN (0.5, 1, 2, 4, and 8 μM), increased the percentage of apoptotic cells from 3.9% to 76.6%, compared to control cells.
3.3. Effect of SAN on the Level of VEGF in MCF-7 Cells
Initially, the cytotoxicity of SAN was investigated with different doses of SAN in human MCF-7 cells by MTT assay. The effects of SAN on the level of the VEGF were also examined in MCF-7 cells. SAN inhibited the viability of MCF-7 cells in a dose-dependent manner. As shown in Figure 4(a), low dose of SAN (0.5 μM) had no effect on the level of VEGF, then 1 and 2 μM SAN treatment increased the VEGF level. On the contrary, it decreased the levels of VEGF after the treatment of high-dose SAN (4, 8, and 16 μM) comparison with the normal control group. H2O2 mimicked the effects of low dose SAN (0.5–2 μM) on VEGF release. The 24 h exposure to H2O2 (5–100 μM) stimulated the release of VEGF from MCF-7 cultures in a concentration dependent fashion. Maximal effect was observed at 50 μM. As assessed with the MTT assay, concentrations from 50 μM to 100 μM affected cell viability (Figure 4(b)). Whereas NAC (0.5 mM to 20 mM) did not result in a significant change of cell viability and VEGF level (Figure 4(c)).
3.4. SAN Enhances ROS Levels in MCF-7 Cells
To investigate whether SAN can increase ROS levels, we examined the intracellular ROS production using a fluorescent probe, DCFH-DA. As shown in Figure 5, after SAN treatment, the fluorescence intensity increased remarkably compared with control group (). In addition, the antioxidants, 10 mM of NAC or 20 kU/L of SOD, were added together with the SAN; results showed that compared with cells treated with SAN alone groups, the fluorescence intensity reduced remarkably, which showed that the NAC and SOD can block the effect of SAN in the enhancement of intracellular ROS levels.
3.5. ROS Are Responsible for SAN-Induced VEGF Change in MCF-7 Cells
We evaluated the effect of SAN on VEGF release in MCF-7 cells. Figure 6 showed that SAN either alone or in combination with NAC or SOD had quite different effects in regulating VEGF release in MCF-7 cells. The VEGF release increased significantly when the concentration of SAN was low and inversed by NAC and SOD. But the VEGF release decreased when the concentration of SAN (4 and 8 μM) gradually increased on the contrary. When added to a final concentration of 10 mM NAC or 20 kU SOD, the VEGF release of 8 μM SAN treatment group increased but still lower than normal control, but the VEGF levels of 4 μM SAN treatment group increased unexpectedly even higher than normal control (Figure 6(a)). Simultaneously, NAC and SOD can suppress SAN-induced cell death in MCF-7 cells (Figure 6(b)). The results revealed that NAC and SOD can suppress low concentration of SAN-induced VEGF release and raise high concentration of SAN-induced VEGF inhibition in MCF-7 cells. ROS generation is crucial for SAN-induced VEGF release.
3.6. SAN Inhibited Steady-State Levels of VEGF mRNA in MCF-7 Cultures
MCF-7 cell cultures were exposed to SAN (1, 2, 4, 8 μM) for 24 h. Total RNAs were extracted and relative VEGF mRNA amounts were measured by real-time PCR and normalized to β-actin mRNA. VEGF mRNA levels were found to be significantly downregulated at 4 μM and 8 μM groups in MCF-7 cultures (over vehicle-treated basal). 10 mM NAC and 20 kU/L SOD can block the VEGF mRNA supression which were induced by 4 μM and 8 μM SAN in MCF-7 cells (). But there were no effects of low concentration of SAN (1 μM and 2 μM groups) on the VEGF mRNA expression (Figure 7). May be high density ROS generation is serviceable for SAN-induced VEGF mRNA inhibition, low concentration of ROS is useless for VEGF mRNA inhibition induced by SAN.
4. Discussion
Human mammary adenocarcinoma cells MCF-7 is a classical cell line obtained from breast cancer patient, and it is used in various kinds of studies of breast cancer. MCF-7 has character of differentiated mammary epithelial cells, such as product estradiol, expressing the receptors of estrogen and progestogen [9]. On the other hand, MCF-7 cell line was more sensitive to the antitumor effect of SAN than other tumor cell lines in this experiment, so we selected the MCF-7 cells and expected that SAN could be effective for the treatment of mammary adenocarcinoma someday clinically.
Apoptosis (or programmed cell death) is a physiological mechanism that is crucial for normal development of organisms during embryogenesis, maintenance of tissue homeostasis in adults, and elimination of diseased or otherwise harmful cells during pathogenesis [10]. Dysregulated apoptosis has been implicated in many human diseases, including neurodegenerative diseases such as Alzheimer disease and Huntington disease, ischemic damage, autoimmune disorders, and several forms of cancer [11]. In this study, SAN was shown to enhance apoptosis and ROS content in human mammary adenocarcinoma MCF-7 cells, and VEGF inhibition depending on ROS generation was involved in this effect, and the inhibitor of ROS can protect MCF-7 cells from apoptosis.
ROS are recently proposed to be involved in tumor metastasis which is a complicated process including epithelial-mesenchymal transition (EMT), migration, invasion of the tumor cells, and angiogenesis around the tumor lesion [12]. Our results suggested that the activity of ROS was increased significantly in MCF-7 cells after the treatment of SAN showed that SAN could mediate ROS production. And the apoptosis rate was increased following the increase of content of ROS and could be protected by NAC.
Moreover, our results showed that SAN deactivated the activity of VEGF significantly at the high concentration but raised the release of VEGF at the subcytotoxic concentration. Vascular endothelial growth factor (VEGF), the most active endogenous proangiogenic factor and an endothelial cell-specific mitogen, is involved in angiogenesis in various types of tumors. In cancer cells, both VEGF and VEGF receptors (VEGFR) are overexpressed. VEGF promotes cancer growth, dissemination, and metastasis, and its expression level is positively correlated with the prognosis of cancer in diagnosed patients or animal models [13–15].
But why is the effect of SAN on VEGF release in MCF-7 cells quite different in different concentrations of SAN group, and also in combination with NAC or SOD group? We found that when the content of ROS was inhibited by NAC or SOD, the increased VEGF expression induced by low concentration of SAN (1 and 2 μM) was inhibited immediately. This phenomenon may be due to that the low concentration of SAN induced low content of ROS, the low concentration of ROS promoted the release of VEGF, and antioxidant canceled the generation of ROS, then the intracellular ROS approached normal level, so the expression of VEGF was reduced; in other words, the low concentration of ROS is critical for the release of VEGF. As shown from the results, 2 μM SAN treatment of SAN induced production of VEGF, but not in the mRNA level change. This may be because that low level of ROS could not inhibit the mRNA of VEGF, and fortunately, could activate the upstream signal transduction pathways of VEGF in MCF-7 cell. On the one hand, ROS can also upregulate VEGF secretion and VEGFR expression through induction of transcription factors HIF-1, suppressing HIF degradation increasing HIF production. On the other hand, ROS mediate transcriptional activation via NF-κB and translational activation via PI3K/AKt/4E-BP1 pathway [16].
Actually, it has also been reported that ROS play a critical role in the expression of VEGF. VEGF is supposed to utilize ROS as a messenger intermediates downstream of the VEGF receptor-2. Inhalation of diesel exhaust particles induction of ROS in capillary-like endothelial tubes leads to VEGF-A expression. Atorvastatin reduces VEGF expression in human nonsmall cell lung carcinomas (NSCLCs) via inhibition of ROS production. Psoriasin may therefore play a role in breast cancer progression by promoting oxidative stress response and angiogenesis. Tetramethylpyrazine inhibits hypoxia-induced pulmonary vascular leakage in rats via the ROS-HIF-VEGF pathway [17–22].
But the regulation of SAN on VEGF did not in a concentration dependent manner; SAN deactivated the activity of VEGF at the high concentration (4 and 8 μM), and the inhibition was inversed by 10 mM of NAC and this concentration of NAC, could block the high level of ROS in MCF-7 cells induced by SAN markedly. Combining the experimental results that SAN upregulated the content of intracellular ROS, we supposed that high concentration of ROS was not as the signaling molecules or second messengers but promoted oxidative stress response simultaneously and inhibited the expression of VEGF mRNA. And after the treatment of antioxidants, the levels of intracellular ROS were weakened and approached to low levels, and low levels of ROS did not inhibit VEGF expression but promoted the release of VEGF. Accordingly, we observed the interesting phenomenon.
Therefore, we concluded that SAN induced apoptosis in MCF-7 cells via the inactivation of VEGF through an ROS-dependent manner. Then why does 2 μM of SAN induce protein levels of VEGF but still does not promote cell survival? Is there other mechanisms that participate in the apoptosis of MCF-7 induced by SAN? And how about the borderline between the positive and negative effect on VEGF levels induced by ROS? What is the least concentration of ROS that can suppress the release of VEGF? To resolve the above issues, we may need more studies in the future.
Authors' Contribution
Xian-zhe Dong, Miao Zhang, and Kun Wang contributed equally to this work.
- W. Y. Choi, C. Y. Jin, M. H. Han et al., "Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis via down-regulation of AKT and activation of caspase-3," Anticancer Research, vol. 29, no. 11, pp. 4457–4465, 2009. View at Google Scholar · View at Scopus
- H. Park, E. Bergeron, H. Senta et al., "Sanguinarine induces apoptosis of human osteosarcoma cells through the extrinsic and intrinsic pathways," Biochemical and Biophysical Research Communications, vol. 399, no. 3, pp. 446–451, 2010. View at Publisher · View at Google Scholar · View at Scopus
- M. Sun, W. Lou, J. Y. Chun et al., "Sanguinarine suppresses prostate tumor growth and inhibits survivin expression," Genes and Cancer, vol. 1, no. 3, pp. 283–292, 2010. View at Publisher · View at Google Scholar · View at Scopus
- M. Sun, C. Liu, N. Nadiminty et al., "Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion," Prostate, vol. 72, no. 1, pp. 82–89, 2012. View at Google Scholar
- H. Tsukamoto, S. Kondo, Y. Mukudai et al., "Evaluation of anticancer activities of benzo [c] phenanthridine alkaloid sanguinarine in oral squamous cell carcinoma cell line," Anticancer Research, vol. 31, no. 9, pp. 2841–2846, 2011. View at Google Scholar
- J. S. Lee, W. K. Jung, M. H. Jeong, T. R. Yoon, and H. K. Kim, "Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway," International Journal of Toxicology, vol. 31, no. 1, pp. 70–77, 2012. View at Google Scholar
- G. Volpi, F. Facchinetti, N. Moretto, M. Civelli, and R. Patacchini, "Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts," British Journal of Pharmacology, vol. 163, no. 3, pp. 649–661, 2011. View at Publisher · View at Google Scholar · View at Scopus
- X. L. . He, P. Zhang, X. Z. Dong, M. H. Yang, S. L. Chen, and M. G. Bi, "JR6, a new compound isolated from Justicia procumbens, induces apoptosis in human bladder cancer EJ cells through caspase-dependent pathway," Journal of Ethnopharmacology, vol. 144, pp. 284–292, 2012. View at Google Scholar
- J. Ye, M. H. Li, X. Long, H. J. Wan, and Z. Fan, "Molecular characterization of breast cancer cell line MCF-7," The Practical Journal of Cancer, vol. 27, no. 2, pp. 116–119, 2012. View at Google Scholar
- P. Meier, A. Finch, and G. Evan, "Apoptosis in development," Nature, vol. 407, no. 6805, pp. 796–801, 2000. View at Publisher · View at Google Scholar · View at Scopus
- J. C. Reed, "Apoptosis-based therapies," Nature Reviews Drug Discovery, vol. 1, no. 2, pp. 111–121, 2002. View at Google Scholar
- W. S. Wu, "The signaling mechanism of ROS in tumor progression," Cancer and Metastasis Reviews, vol. 25, no. 4, pp. 695–705, 2006. View at Publisher · View at Google Scholar · View at Scopus
- A. Rapisarda and G. Melillo, "Role of the VEGF/VEGFR axis in cancer biology and therapy," Advances in Cancer Research, vol. 114, pp. 237–267, 2012. View at Google Scholar
- M. Das and H. Wakelee, "Targeting VEGF in lung cancer," Expert Opinion on Therapeutic Targets, vol. 16, no. 4, pp. 395–406, 2012. View at Google Scholar
- J. Waltenberger, "VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus," Biochemical Society Transactions, vol. 37, no. 6, pp. 1167–1170, 2009. View at Publisher · View at Google Scholar · View at Scopus
- J. Du, R. Xu, Z. Hu et al., "PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1α expression in MCF-7 breast cancer cells," PLoS ONE, vol. 6, no. 9, Article ID e25213, 2011. View at Google Scholar
- E. Shubbar, J. Vegfors, M. Carlström, S. Petersson, and C. Enerbäck, "Psoriasin, (S100A7) increases the expression of ROS and VEGF and acts through RAGE to promote endothelial cell proliferation," Breast Cancer Research and Treatment, vol. 134, no. 1, pp. 71–80, 2012. View at Google Scholar
- T. Maraldi, C. Prata, C. Caliceti et al., "VEGF-induced ROS generation from NAD(P)H oxidases protects human leukemic cells from apoptosis," International Journal of Oncology, vol. 36, no. 6, pp. 1581–1589, 2010. View at Publisher · View at Google Scholar · View at Scopus
- M. W. Chao, I. P. Po, R. J. Laumbach, J. Koslosky, K. Cooper, and M. K. Gordon, "DEP induction of ROS in capillary-like endothelial tubes leads to VEGF-A expression," Toxicology, vol. 297, no. 1–3, pp. 34–46, 2012. View at Google Scholar
- J. Chen, B. Liu, J. Yuan et al., "Atorvastatin reduces vascular endothelial growth factor (VEGF) expression in human non-small cell lung carcinomas (NSCLCs) via inhibition of reactive oxygen species (ROS) production," Molecular Oncology, vol. 6, no. 1, pp. 62–72, 2012. View at Google Scholar
- L. Zhang, M. Deng, and S. Zhou, "Tetramethylpyrazine inhibits hypoxia-induced pulmonary vascular leakage in rats via the ROS-HIF-VEGF pathway," Pharmacology, vol. 87, no. 5-6, pp. 265–273, 2011. View at Publisher · View at Google Scholar · View at Scopus
- E. Monaghan-Benson and K. Burridge, "The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species," The Journal of Biological Chemistry, vol. 284, no. 38, pp. 25602–25611, 2009. View at Publisher · View at Google Scholar · View at Scopus


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I recently had the pleasure of photographing Carolyne Roehm: author, designer and former President of the Council of Fashion Designers of America. The CFDA celebrates its 50th anniversary at the 2012 CFDA Fashion Awards this Monday.
Looking for a photographer to create an author portrait or capture a special event with an author? Contact me.


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July 1 is months away, I know but……
I have lived in Canada for all of my life, I have eaten everything from bannock to moose to dulse to smoked meats and loads of seafood, for the life of me I can't put my finger on what 1 meal is Canadian , so I decided to have one standout recipe from each Province and Territory and post all that I pick and give you credit. (I like to have recipes for 4) but I will adjust for my needs.
I will also need the best wine from your Province or Territory
If you have any suggestions or know someone who would like to contribute please please please write your ideas on my blog on the Contact Page. #debonfare @debfayant debonfare.ca @fayantdeborah
Thank You Thank You Thank You Deborah


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Start here. Go anywhere.SM
Resources for:
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Find flexible ways to finish your degree faster.
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Training & Seminars
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Explore NWTC Locations »
In accordance with NWTC's mission and vision, as well as Federal guidelines, training about the policy and procedures regarding sexual misconduct, assault and relationship violence is recommended for all students, and required for all new and current instructors, and staff. Best practices identified through the United States Department of Education and Violence Against Women Act will be used to develop awareness programs. Additional programs and offerings will be available for students and employees through Human Resources and Student Involvement.
Not Anymore training for students is an interactive online program designed to prevent sexual assault, dating and domestic violence, and stalking. To take the recommended student training, click on the following link: Not Anymore.
Employees are required to take the online Responsible Employee training. Click on the following link to learn more about this and other training opportunities for employees.
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"Project Seawolf" Build Log: 1 Parts
Updated: 04/28/2016
Main Components:
Case: CaseLabs Magnum TH10A – Already have
- Magnum TH10A add-on Bottom Pedestal – On order
MB: MSI Z170A Power Gaming Titanium Edition – Already have
CPU: I7 6700K – Already have
RAM: Corsair 32GB Dominator Platinum – Already have
PSU: Corsair AX 1200i – Already have
HD #1: Samsung V-Nand SSD 950 PRO M.2 512GB – Already have
HD #2: Samsung V-Nand SSD 850 EVO 500GB – Already have
GPU: Awaiting Nvidia new Pascal GPU! (GTX 1080Ti maybe)
Fans: 16 Corsair SP 120 White LED – Already have
- 1 Corsair AF 120 White LED – Already have
- 4 Corsair AF 140 White LED – Already have
Accessories: NZXT HUE+ Case LED Lighting – Already have
Mouse: Logitech X Master Wireless Mouse – On Order
Keyboard: Corsair Gaming K70 RAPIDFIRE Mechanical Keyboard – On Order
OS: Windows 10 Home 64 Bit – Not Yet Ordered, (In Amazon Cart)
Monitor: TDB (Something Ultra Wide and likely Curved)
Water Cooling:
1 EK-Supremacy EVO Nickel Plexi CPU Water Block – Already have
4 Black Ice Nemesis 480 GTX Radiators – Already have
1 Aquaero 6 PRO (Fan Controller) – On Order
Reservoir System for 2 loops – On Order
2 D5 Pumps depending on Vertical Reservoir with attached pump each or separate Dual D5 Pumps for each loop system – On Order
Hardline Tubing: Copper Tubing/PTEG/Acrylic (Not fully quite decided)
- Hardline Tube Bending Kit/ 1/2″ Soft Copper L Tubing – TBD
Fittings (Lots): Monsoon/Bitspower (Not fully quite decided)
Other Things:
- Need to Custom Sleeve all the Fans multi colored connection cable with Black Sleeving – Ordered/Already received Kit.
- Will eventually need to order about 4 Custom color Sleeved Cable Set for ATX, EPS, PCI-e Cable from MAINFrameCustom


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To be able to edit a menu that was already created, go to Edit -> Preferences.
In the Hidden Elements section, make sure to check Scripts.
Next to the menu, you will see a script shield icon, select this to bring up the edit dialog box in the property inspector.
When moving the site from one computer to the other, the page the menu was applied to and the CSSMenuWriter folder will need to be added into the Dreamweaver site in the same location relative to the site root as on the original computer.
For example, say you create a site on the PC with the following path as the root:
and the page you apply the menu to is at:
The CSSMenuWriter folder will be created at:
When you move the site to the Mac, you must maintain the same relationship. So if you create the site on your Mac with the root of:
mac harddrive: websites: testSite:
The CSS MEnu Writwer folder will need to be at:
mac harddrive: websites: testSite: CSSMenuWriter
and the page you applied the menu to will need to be at:
mac harddrive: websites: testSite: testfolder: page.htm


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Thoughts, ideas, and resources that I deem worthy of sharing from the passing educational scene.
Writing Ideas for the First Week of School
tags: languagearts writing literacycoach post2blog
Posted from Diigo. The rest of my favorite links are here.
Note: Only a member of this blog may post a comment.


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Hollywood's Elite - The Meteoric Rise and Fall of America's Sex Symbols 3
A Short Bio
Francis Elena Farmer, was born on September 19, 1913, in Seattle Washington. Ms. Farmer won an essay contest from the Scholastic Art and Writing Awards earning $100 top prize. Unfortunately, her essay's subject matter and another prize won while attending the University of Washington, earned her the title of an atheist and Communist.
You see the title of her essay was "God Dies" her look at godless society and the trip was to Russia first prize in a subscription contest for a leftist newspaper called The Voice of Action . While in Russia Francis enjoyed watching the then pioneering Moscow Art Theater perform, unfortunately these two accusatory titles would follow her until death.
Farmer's Rebellious Career
In 1935 upon her return from Russia Francis sought a career in the theater instead she was directed to a talent scout representing Paramount Pictures. Farmer signed a seven year contract offered on her 21st birthday, and cast in several vehicles that were box office gold. Little did she know, at the time, that she would be cast in film after film that played up her appearance and ignored her talent as an actress.
Lack of meaty roles brought out the rebellious streak in the actress. Farmer became very outspoken which made her seem "difficult" to work with and this was not appreciated in an era where the studios dictated the lives of stars on and off the screen.
Francis would not allow the studio to play up or glamorize her private life, refusing to attend the it Hollywood parties, cooperate with set up dates with male stars to play in the gossip columns. Instead of dressing to the nines Farmer would dress down, and rode around in an aged green roadster.
The artist met playwright Clifford Odets, appeared in his play Golden Boy , and engaged in an affair with the married playwright. Reviews of her run in theater were lukewarm, but due to her popularity on screen the play did very well and went on tour nationally. Even though most critics felt the actress was miss-cast for the part. Odets never offered a commitment to their illicit affair, ended the relationship suddenly and cast another actress for Farmers part.
Francis Farmer returned to Paramount with the written understanding that she would only spend 3 months out of a year in Los Angeles and continue her stage work in New York. Her stage runs were short, the movie parts were lackluster and unchallenging. Farmer's work habits, and increasing alcohol abuse, became a continued frustration for Paramount and the studios she was lent to. Francis became temperamental and began displaying erratic behavior.
Legal, Mental and Arrest Woes
Ms. Farmer's downward spiral began in 1942 with a series of arrests form public drunkenness, bench warrants for unpaid fines, assault on a hairdresser, who suffered a dislocated jaw during the scuffle. During an appearance in front of a judge for the assault, Ms. Farmer claimed that her civil rights had been violated and during the session threw an inkwell at the magistrate. Of course she was sentenced immediately to 180 days in jail, as she was escorted out of the court room Farmer attacked two policemen and a matron knocking one of the officers down. After being subdued Francis was heard screaming "Have you ever had a broken heart?"
The arrest was sensationalized in the media and her sister -in-law, who happened to be a Los Angeles Deputy Sheriff had the actress transferred to the psychiatric ward of Los Angeles County General.
After her stay at L.A. County General, Francis was later transferred to the Kimball Sanitarium in La Crescenta, in the San Fernando Valley, where she was diagnosed as a paranoid schizophrenic. Treated with insulin shock therapy Farmer suffered the intense side effects of nausea. She later left the sanitarium after about nine months, walking away from the facility arriving at her half sister's house 20 miles away. Her mother Lillian Farmer sought guardianship of Francis in California, and won taking Ms. Farmer home to Seattle in 1943.
Within six months Francis physically attacked her mother, who inturn committed her to Western State Hospital in Washington. Once there Farmer received electro-convulsive shock treatment, three months later she was given a clean bill of mental health and released. In 1950 after several attempts to run away from her aunts residence in Nevada and another 5 year hospital stay, Francis was again in her mother's custody.
Francis Farmer found work at the Olympic Hotel, the same hotel where in 1936 she walked the red carpet attending the premiere of her movie Come and Get It. In 1954 the actress married a utility worker and moved back to California, leading a virtually quiet life in Eureka. From 1957 to 1964 Farmer worked in stock stage productions, and for a screen magazine. From 1958 to 1964 she hosted a successful TV show called Frances Farmer Presents. Unfortunately, in 1964 Francis Farmer became unstable again, arrested for DUI in '64 and 1965.
Francis Elena Farmer passed away in 1970 due to esophageal cancer.
My Thoughts
The youth orientated, ego driven business that is Hollywood movie making is a venue that allows those of weak character to satiate a hunger that feeds off the adulation of others.
Most are in the business because of money, but a small portion, who crave attention, are thrown into a world that suckles a cash cow until there is nothing left but an empty pathetic shell of a person.
Once spent, the vehicle is discarded like so much rubbish, left to fend on its own, to self medicate wither and die. Its unfortunate that little has changed in the industry, except stronger drugs and easier access to self medicate, and a willingness to repeat the same mistakes.
Very nicely written hub about her.. she is very gorgeous girl , though i can not say i have seen any of her work but i have seen her pics a lot.
Your summation of the Hollywood star-making machine is absolutely correct and quite sobering. It is frightening to consider what will happen to Britney Spears, the Olsen twins, Lindsey Lohann and all the other folks who became a star too soon and too fast. Where will they be in 40 years--or even in ten?
Thanks for sharing this thought-provoking article.
This was quite an interesting read. I was not at all familiar with Frances, even though I had heard of her. Thumbs up!!
Thank you.
Forever His,
Great hub Pmccray. I love these flashbacks and days of black and white! Thanks Dear!
wow, another moving and powerful hub, really i didn't know half of this, totally fasinating. rated up and bookmarked of course.


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The slowest-growing religion in the world is Dudeism. An ancient philosophy that preaches non-preachiness, practices as little as possible, and above all, uh...lost my train of thought there. Anyway, if you'd like to find peace on earth and goodwill, man, The Church of the Latter-Day Dude will help you get started. Right after a little nap.
(via Eclecticity)
The Church of the Latter-Day Dude


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Killer in the backseat
The Killer in the Backseat (also known as High Beams) is a common, car-crime urban legend well known mostly in the United States and United Kingdom.[1] It was first noted by folklorist Carlos Drake in 1968 in texts collected by Indiana University students.[2]
The legend involves a woman who is driving and being followed by a car or truck. The mysterious pursuer flashes his high beams, tailgates her, and sometimes even rams her vehicle. When she finally makes it home, she realizes that the driver was trying to warn her that there was a man (a murderer, or escaped mental patient) hiding in her back seat. Each time the man sat up to attack her, the driver behind had used his high beams to scare the killer, causing him to duck back down.[3]
In some versions, the woman stops for gas, and the attendant asks her to come inside to sort out a problem with her credit card. Inside the station, he asks if she knows there's a man in her back seat. (An example of this rendition can be seen in the 1998 episode of Millennium, "The Pest House".) In another, she sees a doll on the road in the moors, stops, and then the man gets in the back.
In another version, the woman gets into her car and then a crazed person leaps out from nowhere and starts shouting gibberish and slamming their hands on the car. The woman quickly manages to escape from them but no matter how far or which direction she drives, every time she stops, the same crazed person appears and attacks the car. The woman then arrives at a police station and tells the police about the crazed person. The police calm her down and offer to drive her back to her house (or a safe place in other versions). But when they go with her to get her things from the car, they find the killer hiding behind the driver's seat. As it turns out, the crazed person that was chasing the woman was the ghost of one of the killer's victims, trying to either warn the woman or get at the killer.
The story is often told with a moral. The attendant is often a lumberjack, a trucker, or a scary-looking man: someone the driver mistrusts without reason. She assumes it is the attendant who wants to do her harm, when in reality it is he who saves her life.[4]
In popular culture[edit]
- The 1998 film Urban Legend begins with this scenario.[5]
- John Carpenter's 1978 film Halloween has the character Annie Brackett killed when she enters the car and the killer Michael Myers sneaks up from behind the back seat and slashes her throat.
- In the 2013 film Curse of Chucky, Nica Pierce is sent to a psychiatric hospital, suspected of a set of killings committed by Chucky. As the arresting officer gets into his car, Tiffany Valentine, who had been hiding in the back seat, slits his throat with a nail file.
- The first segment, "Terror in Topanga," of the 1983 film Nightmares is a depiction of this legend.
- An episode of the detective series Jonathan Creek, "The Coonskin Cap", begins with a version of this legend, except that instead of a killer inside the car, the pursuing driver is trying to alert the woman that there is a body tied to the back of her car.[6]
- In a 1998 episode of Millennium, "The Pest House", Frank Black chases a doctor from a mental hospital after one of its patients escapes into the back of her car and tries to kill her. When she pulls over at a gas station, the attendant saves her by taking her inside.[7]
- The 2003 Tamil film from India, Whistle, begins with this scenario.
- The story is featured in the television show Beyond Belief: Fact or Fiction.
- The story is featured in an episode of The Simpsons when Otto tells Lisa the legend as a bedtime story. In his version, the victim is chased by another car that keeps ramming her vehicle, and she drives off the road into the woods and loses the other car. She is then killed by an axe-wielding maniac who had been hiding in her backseat.
- In the 2015 episode of Scream Queens, Ghost Stories, Chanel #5 (played by Abigail Breslin) is driving and a truck starts honking at her and using his high beams. When she pulls over at a petrol station, he tells her about the Red-Devil (the murderer), lurking in her back seat but then he is stabbed by it while #5 makes her escape.
See also[edit]
- ^ Brunvand, Jan Harold (2012). Encyclopedia of Urban Legends, Updated and Expanded Edition. Vol. 1. Santa Barbara, California: ABC-CLIO. p. 361. ISBN 978-1-59884-720-8.
Although other car-crime legends are well known abroad, 'The Killer in the Backseat' does not seem to have taken root very strongly outside North America.
- ^ Drake, Carlos. "The Killer in the Backseat." Indiana Folklore 1 (1968), 107-109.
- ^ Bronner, Simon J. (1988). American Children's Folklore. Little Rock: August House Publishers. p. 149. ISBN 978-08748-306-8-2.
... Suddenly, I realized what was happening and did the first thing I could think of. I flashed my brights to warn her. I saw the figure quickly disappear. I followed the car home and flashed my brights each time I saw the figure. After she ran in the house, I told her to call the police...
- ^ Barden, Thomas E. (1991). Virginia Folk Legends. Charlottesville, VA: University Press of Virginia. p. 324. ISBN 978-08139-133-5-3.
The story structure of a suspected harmer turning out to be a savior appears in such modern legends as that of the truck driver following a woman home flashing his lights. For interpretations of this legend, see Carlos Drake ... and Xenia E. Cord, 'Further Notes on the Assailant in the Back Seat'...
- ^ Brunvand, Jan Harold (2012). Encyclopedia of Urban Legends. Vol. 1. Santa Barbara, California: ABC-CLIO. p. 361. ISBN 978-1-59884-720-8.
'The Killer in the Backseat' provided the initial scare in the 1998 film Urban Legend. (In the film, however, the assailant does actually kill the driver.) David Letterman's telling of the legend as he heard it growing up in Indianapolis is included in my book Too Good To Be True...
- ^ Renwick, David (1 March 2003). "The Coonskin Cap". BBC. Archived from the original on 4 September 2014. Retrieved September 3, 2014.
- ^ Handlen, Zack (June 25, 2011). "The X-Files: "The Red And The Black" / Millennium: "The Pest House"". The A.V. Club. Retrieved September 3, 2014.
- Entry at Snopes
- Info at About.com
- Brunvand, Jan Harold. Encyclopedia of Urban Legends. 2001.
- Brunvand, Jan Harold. The Choking Doberman. 1984.


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Beyond Charlottesville: Addressing Underlying Causes of Racism and Violence
Racism and violence, of the kind we saw in Charlottesville, Va, this past week always merit our outage and condemnation. But we have to be careful. Such attitudes pose a subtle danger: they can be overly simplistic and serve to obscure underlying issues that contribute to the unrest. History has taught us that racism and…Continue reading →


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Belated Notification Penalty: When Does A Penalty Arise: Distance selling
Belated Notification Penalty has been replaced by the Failure to Notify penalty introduced by Schedule 41 of the Finance Act 2008. The Failure to Notify penalty applies to obligations to notify HMRC of a liability to be registered for VAT on or after 01/04/2010. The Belated Notification Penalty under Section 67 VATA 1994 continues to apply to obligations to notify a liability to be registered for VAT before 01/04/2010.
Please see the Compliance Handbook CH70000 for more details about the new failure to notify penalty.
From 1 January 1993 if a trader who operates in the European Community
- exceeds the registration threshold for distance sales, or
- makes distance sales of excisable goods, for any amount.
The trader must notify HMRC of a liability to register in the UK within 30 days after the day the liability arises in accordance with the VAT Act 1994, Schedule 2, paragraph 3. If they do not, they will be liable to a belated notification penalty.
Note: Further guidance on registration and registration thresholds can be found in V1-28 Registration.


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Advocating WITH Your Child: Talking to My Daughter's Classmates about Her Disability
By Anna Stewart
When my daughter Sabrina was in first grade, the other children started to ignore her. She would try to say something, but the other child would not understand and just walk away from her. Some started to call her a baby due to her severe speech issues. After wiping away a few tears, I asked the teacher if I could come in and talk to the children about the situation.
As part of my intention to advocate WITH my daughter, I asked her what she wanted the kids to do differently. She wanted two things: not to be ignored and to be understood. Her wishes were the foundation of our conversation with the kids and the teachers. Since the kids were young, they did not need to have a lecture on her disability. They needed to be heard and to be partners with Sabrina in communication.
With Sabrina by my side, we all sat on the floor in her classroom. Like most people, the kids had been subtly taught not to talk about differences. They knew it was impolite to stare or ask about disabilities. That was part of the problem, so the first thing I did was state facts. "It's hard for Sabrina to speak clearly," I told them. "But that doesn't mean she has nothing to say. She wants to be understood just like you do." And then I gave them the power: "What could you do to understand her better?"
The result was magical and brought tears to my eyes. The kids interrupted each other in their excitement to share their ideas. When her classmate Lillie suggested she do sign-language (and then I asked her if she knew sign-language so she could understand Sabrina), I could practically see the light bulb go off as she deepened her understanding of being a partner to Sabrina. Micah offered to teach her the new dot-language he had developed. Emma put her hands behind her ears so she could hear her better. Then Emily shared that what she always does is listen carefully and then ask Sabrina to say it again if she doesn't understand her. The teacher suggested asking Sabrina what the first letter of the word she is trying to say is, or ask her to write it down. Brilliant.
By the end of the brainstorming session, the kids felt much more capable of being caring communication partners to my daughter. The students had strategies to try. They also had freedom to talk about her speech issues — it was no longer a secret (that everyone knew). Sabrina started to get more invitations for play dates and birthday parties. She was seen as a full classmate.
Another mom I worked with went to talk to her son's 2nd grade classmates. Her son Jason was non-verbal. He was easily frustrated and affected by autism. He often hit or pushed his classmates. When his mom talked to the class, one thing they needed was to be able to share how scared they got when he lashed out. That was the secret they held in. They needed permission to be afraid and once they had that, they also felt they had permission to take action. The students felt they had more control over their own feelings. And that translated to them putting limits on Jason's actions. They started telling him not to hit or push and giving him more appropriate ways to connect with them. They played tag with Jason but would stop and walk away if he hit them. Everyone felt more relaxed, and that also helped Jason stay regulated.
Partnering with classmates is the goal of talking to them about your sons or daughters differences. As children get older — say 4th or 5th grade — they may have some questions about the diagnosis. That natural curiosity is also in your child, and is a sign to start talking to them about their own needs. It's all part of the journey of advocating WITH your child to help them become an adult who knows who they are, how they learn and how to work with their differences.


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River-Related Links
History of Windmill Marina
"Spreeman's Landing", a commercial fishing and boat rental business, was established around the year 1900 on a beach that is the present site of the gas dock. Crystal Spreeman sold the property to Bill and Bert Skluzacek in 1956.
Read More...
Read More...
Visit Our Facebook Page
Suggestion Box
What are we doing well? How can we do better? Let us know!
Complete the ONLINE FORM
Complete the ONLINE FORM


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Michele requested feedback from the group regarding the template for the online borrower's chart created by Sam McDonald. Members of the group had copied and pasted all the Primary and Guest borrower categories into a word document and then passed these on to Sam McDonald. Group members liked the chart and thought this would be much easier to use than the paper copies. Some questions and concerns that came up were:
Would this HTML file be printable? How would the chart be updated? Is searching by keyword possible?
The answers to these questions were:
Sam McDonald will make sure the chart is printable. The Circulation group will work with the Head of Access Services to maintain the chart. The chart is keyword searchable by using "CTRL F."
A vote was taken as to whether the chart should be alphabetical or separated into primary and secondary borrowers. The majority of the group liked the chart separated into Primary and Guest columns. Three members voted for alphabetical and six members voted for primary/ secondary.
The group reviewed an edited version of the circulation quiz designed for students (and possibly staff). After reading through the questions, the group agreed that the questions were good. It was suggested that we include additional questions on the following topics: remote access, checking out damaged materials, and dealing with accompanying materials.
The group emphasized the importance of using this document as part of a training tool: while it is helpful to create online tests and documents, most of the student learning should be done under the guidance of student coordinator. Michele will set up a SAKAI or WebCt page with the test questions.
Jill Morrow is now responsible for brochures. Requests for them, along with signs and book bands, can be made online.
Though many of the lesser-used brochures are no longer available in bulk, they can be found in printable format online. To order brochures go to Staff resources, Access Services, Public Service, Forms and Active Publications.
The group reviewed the service desk standards to keep them fresh in their minds as the new semester approaches.
The Service Desk standards are available online under staff resources, Access Services, policies.
The opportunity to ask questions was given.
The group reviewed how to register a patron. In order to register with the libraries, a patron must have either a current student or Faculty/Staff ID, a record in the library database or a paid term bill in order to receive borrowing privileges. Finding the user's name in the online directory is not considered a valid id.
Q: With branch libraries relying heavily on student help, should student help register new users? Is a standardized procedure for this necessary?
Michele will talk with Andy and Roger regarding this question.
Dean will run the next group meeting. As has previously been discussed, the group will be divided into two sections. Michele will lead one and Dean the other, and then the groups will come together. The responsibilities of these two sections were briefly discussed.
Dean: This group will focus on the more technical aspects of circulation. Members will be instructed in and gain experience with project management. Examples of possible projects include: automated claims returns, linking RA cards to the faculty member's record and J client training issues.
Michele: This group will focus more on training, documentation, and user maintenance. Members will update and maintain online documentation for staff, as well as provide assistance for any training issues that may arise. Some example of a possible project is working to delete 900 duplicate user records.
Q: Can membership alternate between the two groups?
Members of the circulation group should determine which group work and projects appeal to their own growth, interest and professional development, and commitment of time. Dividing the group will be in a test phase for this semester. Depth of involvement, however, will vary according to local staffing needs. Group members can work on projects with Dean for the semester and then group members can rotate again.
Kilmer: A bathroom is currently being installed on the ground floor level.
Annex: Work continues on bar-coding and cataloging materials.
Chang: Completed a shift of the periodicals. A smaller reorganization of the circulation shelves is also being done. Many fall reserves have come in.
Douglass: Kelly(admin) is back. Work on the Lennox papers is also being conducted.
Chemistry: The floor plan is being reorganized to accommodate a separate reference section and to make the space more usable.
Alexander: Due to budget cuts, the merger of the undergraduate reserve desk and the circulation desk will take place this semester. This will most likely result in increased traffic at the circulation desk.
LSM: The weeding project is close to its 35,000-volume mark. Weeding will continue, with additional volumes being routed to Better World Books and the book sale. Many fall reserves have come in


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Royal Caribbean InternationalSovereign the Seas Review4 Day Bahamas Lorraine Dowie
Age: 50
Number of Cruises: 3
Cruise Line: Royal Caribbean
Ship: Sovereign of the Seas
Sailing Date: October 10th, 2005
Itinerary: NOT FOUND
Royal Caribbean International
Sovereign of the Seas Cruise Review
4 Day Bahamas Cruise
Lorraine Dowie
This was our third cruise with Royal Caribbean, the first being the beautiful Enchantment of the Seas and the second the huge Mariner of the Seas. After booking this Bahamas cruise I read some reviews and was very apprehensive however it turned out to be an abolute delight. We encountered no noisy teenagers, bad smells or tiny cabins. Check in was quick and efficient and we were in our cabin by 2pm, we had an oceanview on deck 6 and although not huge it was big enough for two people. The bathroom was bigger than I expected. Our luggage arrived very quickly at our cabin and we were unpacked and enjoying lunch in the Windjammer by 3pm. Cabin service was excellent as was the food. There was a great choice of excursions but we chose to explore by ourselves. Take a buggy ride in the Bahamas, it was only $10 and the guide was very informative. Only complaint was waiting hours to disembark at the end of the cruise, if you are not catching at flight you are left till the very end which is a very long wait, if you do not have much luggage it is best to ask for an early disembarkment carrying your own luggage.
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Friday, September 20, 2013
Then came diabetes. And it seemed as if the whole world had changed. Before the world seemed like a place full of love and now all I saw was sadness and pain. Now to be clear, I realize I wasn't the one with the broken pancreas, but I am a mom and my heart was broken. (And I mean shattered into a million little pieces.)
In this new world, our focus was diabetes, diabetes, diabetes. We had to learn how to best take care of our son. It was time to circle the wagons and focus on our family. There was no longer time for volunteer work. And Sunday mornings became a time to steal some extra sleep. (As any T1 family knows, taking care of diabetes is exhausting.) What was left of my broken heart just wasn't moved to go to church. And slowly, over time our family just stopped attending Sunday mass.
It is now 4 years AD (after diabetes). And we have adjusted to our "new normal." (I always hated that phrase.) Slowly, my broken heart is mending and I think it's leading me back to church. So this past Sunday, I dragged myself and the boys out of bed and went to Sunday mass. It was time to give it another try.
The gospel reading for the week (yes, I am Catholic) was the story of the Prodigal Son. When the priest started reading I thought … Hey, this is story of a man who left his family and then returned begging for forgiveness, maybe this is a sign, and maybe God is speaking to me. So I sat up straight and forced myself to listen. But then the priest read the story of the young son who asked his father for his inheritance and then ran off and squandered it on partying and extravagant living. Wait that's not me! I haven't spent the last 4 years partying. My life has been quite the opposite. That sounds like fun but that's not me. And sadly I thought … this is not a sign.
But then, that's not the end of the story. After the son begs for forgiveness the father decides to throw a party. Then enters the bitter older brother who complains he has worked hard and remained loyal and done everything "right." He then asks his father, "What about me?" Ahhh, now this is sounding a little more like me. I thought I was doing everything "right" too. And maybe my broken heart was a little bitter too. And maybe I too want to ask, "What the heck is going on here?" Alright … now I am paying attention again. How does this story end? What does the bitter brother decide to do?
But wait … that is the end!? We never learn if the bitter brother goes to the party? I suppose the real question is what am I going to do? Am I going to join the party? I did, at least, open the door and came in ...
The truth is we are no longer the typical family. Our world has changed (some it for the better). And in our new world … which is filled with countless sleepless nights filled with too many highs and lows … sometimes sleeping in on a Sunday morning might be the "right" thing to do. Living with diabetes has taught us a lot. And one thing we have learned is … you have to take each day one at a time. So for now, I will take each Sunday one at time. And I suppose I will just follow my heart.
2 comments:
Wow...I have thought about that reading a million times, but not in that way. I keep revisiting how the priest talked about the pivotal moment of the entire story not being about the older brother, or the father, but instead, about the moment of conversion within the heart of the wayward son.ReplyDelete
It is all about that moment...the moment, not that you realize you are out of money and need to come home for a good meal, but the moment you realize that you were totally undeserving and push through, despite your shame and humiliation to ask for forgiveness and acceptance. It is really about pride, and how pride holds us back, and how surrendering your pride and coming back to those whom you have wronged is such an act of humility.
Anyhow, that is how I heard it last week! Any thoughts!Replies
I totally agree with you! ... I definitely pulled out one short segment of the story ... the older brother seemed like a real reflection of the confusion in my heart ... my response to the story had less to do with the actual message (about forgiveness) ... and more about my surprise with which brother I related to.Delete
Thanks for your thoughtful response!


text: The CME merging with the CBOT set to take place in 2007 is being touted as good for the exchanges and for Chicago. How will the merger affect the futures traders who trade their products? I wonder if there will be any immediate benefits to those trading their contracts such as the e-mini S&P or the US Ten Year note electronically.


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Sweet Pea is 24 months old.
From: My mom suggested this. She says that she used to do this with me when I was a tot. 🙂
Sink. Sturdy chair or step stool. Sponge, measuring cups, old produce (like a carrot or piece of lettuce), dish wand or other […]


text:
Christmas Plaid Shirt Baby
Buy ONE'S Baby Toddler Girls Boys Red Plaid Shirts Long Sleeve Big Check Blouse. Warm Red Buffalo check long sleeve blouse, good for Christmas Outfits
Classic infant or toddler boys Christmas pajamas in soft cotton feel polyester red tartan plaid are perfect for Christmas morning! Button front red tartan plaid shirt .
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Make it a holiday to remember with Christmas outfits from Old Navy. Shop cute Christmas outfits. Built-In Flex Plaid Flannel Pocket Shirt for Boys. Hi, I'm New .
They'll sparkle in Christmas clothes at Carter's holiday shop. Discover the holiday looks from the trusted name in baby & kids' clothes.
Buy 2018 Baby Christmas Clothings Newborn Toddler Swaddle Button Plaid Shirt Casual Tops at Wish – Shopping Made Fun.
Buy Baby Christmas Clothings Newborn Toddler Swaddle Button Plaid Shirt Casual Tops at Wish – Shopping Made Fun.
This buffalo plaid Christmas tree is the perfect little Christmas time shirt for your little one. This raglan is perfect for a Christmas shirt but its also one that can be .


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The National Institute of Standards and Technology has released three special publications dealing with information security.
SP 800-111, Guide to Storage Encryption Technologies for End User Devices, is published as final. It is intended to assist organizations in understanding storage encryption technologies for end user devices, such as laptops, PDAs, smart phones, and removable media, and in planning, implementing, and maintaining storage encryption solutions. The publication provides practical, real-world recommendations for three classes of storage encryption techniques: full disk encryption, volume and virtual disk encryption, and file/folder encryption. SP 800-111 also discusses important security elements of a storage encryption deployment, including cryptographic key management and authentication. SP 800-114, User's Guide to Securing External Devices for Telework and Remote Access, is published as final. It is intended to help teleworkers secure the external devices they use for telework, such as personally owned desktop and laptop computers and consumer devices (e.g., cell phones, personal digital assistants [PDA]). The publication focuses on security for telework involving remote access to an organization's nonpublic computing resources. It provides practical, real-world advice on securing telework computers' operating systems and applications and teleworkers' home networks, and it also gives basic recommendations for securing consumer devices. SP 800-114 also provides tips on considering the security of a device owned by a third party before deciding whether it should be used for telework. Draft SP 800-115, Technical Guide to Information Security Testing, is available for public comment. It seeks to assist organizations in planning and conducting technical information security testing, analyzing findings, and developing mitigation strategies. The publication provides practical recommendations for designing, implementing, and maintaining technical information security testing processes and procedures. SP 800-115 provides an overview of key elements of security testing, with an emphasis on technical testing techniques, the benefits and limitations of each technique, and recommendations for their use. Draft SP 800-115 is intended to replace SP 800-42, Guideline on Network Security Testing, which was released in 2003. Please visit the drafts page to learn how to submit comments to this draft document.
Source: NIST News and Events, 16 November 2007


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Welcome to Echo Valley!
Echo Valley is a free, just for fun, radio show that celebrates bubblegum pop music from the 1960's and 1970's.
The Echo Valley podcast is at echovalley.podbean.com!
You can download all episodes of Echo Valley below or from the archive to the right.
If you'd like to subscribe for free to the podcast, you'll find Echo Valley on iTunes, or, to do it your own way, here is the "feed" URL you will need to know: http://echovalley.podbean.com/feed.
Contact the Mayor's office at firstname.lastname@example.com .
The Echo Valley podcast is at echovalley.podbean.com!
You can download all episodes of Echo Valley below or from the archive to the right.
If you'd like to subscribe for free to the podcast, you'll find Echo Valley on iTunes, or, to do it your own way, here is the "feed" URL you will need to know: http://echovalley.podbean.com/feed.
Contact the Mayor's office at firstname.lastname@example.com .
Sunday, November 25, 2018
Saturday, October 13, 2018
EV129 (S5E29) Kristy McNichol
Wednesday, September 26, 2018
Ev128 (S5E28) The Clapping Song
Thursday, September 6, 2018
EV127 (S5E27) Bingo Bingo
Sunday, July 29, 2018
EV126 (S5E26) Short and Sweet
Wednesday, June 13, 2018
EV125 (S5E25) Joey Levine
Tuesday, May 15, 2018
EV124 (S5E24) Bubblegum Wisdom
Sunday, April 29, 2018
EV123 (S5E23) Scooby-Doo and Lancelot Link
Sunday, April 15, 2018
EV122 (S5E22) The Cowsills
Tuesday, February 20, 2018
EV121 (S5E21) Rare Bubblegum
Monday, February 5, 2018
EV120 (S5E20) David Cassidy
Saturday, December 9, 2017
EV119 (S5E19) A Bubblegum Christmas Card to You
Sunday, November 5, 2017
EV118 (S5E18) Waldo P. Emerson Jones
Thursday, October 19, 2017
EV117 (S5E17) Clap Your Hands and Stamp Your Feet
Tuesday, September 26, 2017
EV116 (S5E16) Karen Valentine Beauty Secrets
Sunday, September 10, 2017
EV115 (S5E15) Mission Magic
Sunday, August 20, 2017
EV114 (S5E14) Bubblegum Dream
Sunday, August 13, 2017
EV113 (S5E13) The Beagles
Monday, July 3, 2017
EV112 (S5E12) Jingle Jangle
Saturday, May 20, 2017
EV111 (S5E11) Bubblegum Circus
Saturday, April 22, 2017
EV110 (S5E10) The Hardy Boys
Sunday, March 26, 2017
EV109 (S5E9) Tony Orlando
Monday, March 13, 2017
EV108 (S5E8) Josie and the Pussycats
Saturday, February 25, 2017
EV107 (S5E7) The Cattanooga Cats
Saturday, December 10, 2016
EV106 (S5E6) A Very Merry Cherry Cherry Christmas
Saturday, November 26, 2016
EV105 (S5E5) The Danny Bonaduce Album
Saturday, October 22, 2016
EV104 (S5E4) Partridge Family Rarities
Saturday, October 1, 2016
EV103 (S5E3) I Want Candy
Monday, September 5, 2016
EV102 (S5E2) It's a Groove to Be Free
Sunday, August 28, 2016
EV101 (S5E1) Be Young, Be Foolish, Be Happy
Sunday, August 7, 2016
EV100 The History of Bubblegum Music
Tuesday, July 19, 2016
Summer Rerun EV30 (S1E30) Best of Season 1
Friday, June 24, 2016
Summer Rerun EV60 (S2E30) Best of Season 2
Sunday, April 17, 2016
EV99 (S4E19) Best of Season 4
Sunday, February 21, 2016
EV98 (S4E18) Bubblegum Bounces Back!
Monday, December 21, 2015
EV97 (S4E17) The Echo Valley Christmas Special That Almost Wasn't
Thursday, October 29, 2015
EV96 (S4E16) Still Another Bubblegum Intervention
Saturday, September 26, 2015
EV95 (S4E15) Another Bubblegum Intervention
nother hour of the bubbliest, most inspiringly gummiest, upbeat funnest bubblegum popiest music you're likely to hear. This time this really will cure what ails you. A tribute to Boyce and Hart! The songs of Johnny Cymbal! A reading of a teen advice column from a 1968 Tippy Teen comic book! The Echo Valley Time Machine goes back to 1904 for the Woodchuck Song! Plenty of healthy bubblegum music from The Archies, Giorgio, The Music Explosion, Mama Cass, The Strangeloves, The Blue Mink, The Glamrock Brothers, Roger Krug with Billy Action, Joyride, The Partridge Family, The Easybeats and Anders 'N' Ponica!
Saturday, August 29, 2015
EV94 (S4E14) Bubblegum Intervention
n hour of the bubbliest, most inspiringly gummiest, upbeat funnest bubblegum popiest music you're likely to hear. This will cure what ails you. A look at the famous Kasenetz-Katz Singing Orchestral Circus live Carnegie Hall concert original cast recording! A dramatic reading of a David Cassidy comic book! The best Saturday morning cartoon bubblegum band theme songs, including the rare theme songs from Sabrina the Teenage Witch and Butch Cassidy and the Sundance Kids! Hear essential bubblegum music from The Archies, Banana Splits, Andy Kim, The Groovie Goolies,The Brady Bunch, Scooby Doo, Where Are You?, Josie and the Pussycats, The Hardy Boys, The Harlem Globe-trotters, The Hot Wheels, The Cattanooga Cats, The Partridge Family, Sha Na Na, and Tony Ronald!
Friday, July 24, 2015
EV93 (S4E13) Gomer Says Hey
Friday, June 26, 2015
EV92 (S4E12) Worst Comic Book of All Time
Sunday, May 31, 2015
EV91 (S4E11) Giorgio
Monday, May 4, 2015
EV90 (S4E10) Patty Duke
Saturday, April 18, 2015
EV89 (S4E9) Bubblegum According to Bennie D.
Saturday, April 4, 2015
EV88 (S4E8) Harlem Globetrotters
Sunday, March 15, 2015
EV87 (S4E7) Yummy Love
Monday, January 19, 2015
EV86 (S4E6) Free and Easy
Wednesday, December 10, 2014
EV85 (S4E5) Very Merry Bubblegum
Tuesday, November 25, 2014
EV84 (S4E4) Kisses for Breakfast
Sunday, November 9, 2014
EV83 (S4E3) Sweeter than Sugar
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Editor's Note: On Saturday, January 29, Gil Schamess died at his home at the age of 34, just six months after learning he had metastatic liver cancer. Before his death, Gil and Lisa wrote a column for Beliefnet on their struggle to live with his illness. With this column, Lisa begins the story of her new life with their 15-month-old daughter, Mona.
A few nights after Gil's diagnosis last summer, we lay in the dark discussing entropy. We pondered whether chaos, which slows down when it meets resistance, could be directed away from a vulnerable place. The cancer was still only a spattering of X-rayed shadows on Gil's liver and lungs. What cosmic force might disperse them, we wondered, when medicine offered so little hope? Talk had served us well in the past, bridged the bright space between our separate selves by day and the dark space between our bodies at night, mended our differences, tickled our ribs. Now we were desperately trying to talk chaos away from our bed.
Gil had nearly majored in physics in college, but there was never hope for me as a scientist. I always carry the logic too far, shaking a proven theory vigorously for further implications, wanting 20 falling apples where one should do.
"There's a way to prove that gravity is an effect, not an objective force," said Gil. "Say you put a marble on a not-so-taut drum skin, and you make a little depression. Put a medicine ball there, and you make a bigger one. Put the marble down again, and, eureka, it rolls toward the bigger depression. Gravity as effect instead of cause."
"What were we talking about this for?" I was tired, confused, anxious for epiphany.
"We were talking about dimensions, perception, and how space can be bent," said Gil.
"If space can be bent, is it a substance?" Shaking the tree again. I couldn't see his face, just the glimmer along his profile, like an eclipsed sun.
"That's a very good question."
"If space is a substance, can absence be a presence?" My journal entry of that night reflects no answer.
|Now that Gil is gone, his absence is everywhere present.