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Home Elevation for Protection from FloodsLight Emitting Diodes are gaining high popularity all around the globe since these lighting items are laden with superior features and are manufactured with good quality materials. The LED Lighting Systems are extensively used in televisions, traffic lights, car headlights, torches and signs across the globe. These are energy efficiencies, involve low maintenance costs, have high strength, and so are durable, and take in the minimum level of energy. These are highly far better to use, much easier to maintain, can be bought in solid state and they are much much easier to dispose off after use. Unlike other lights, these do not emit any harmful chemicals that will make them highly preferred to be found in various areas of the property and offices and they usually do not get heated up easily which makes them safer for youngsters to touch.
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Reported by: Jiang Qinghua
Translated by: Qiao Xuechao
Edited by: D. Parker
Time: 2018/1/2
HIT recently celebrated the inauguration of a national key research plan on precision medicine—100,000 Chinese People Genome Project & plural groups reference database and analysis system in China. National funding is an estimated 89,850,000 yuan, to be allocated over an initial four year implementation stage. The project team will select 100,000 Chinese citizens for the research project focusing on omics research in genome, exposure and phenotype. This will provide for genome mutation mapping and multi-omics health mapping of Chinese people. The project will be of great significance in revealing specific genome mutations, frequency of mutation amongst Chinese and its impact. It will provide reference data for developing future personalized medical treatment and health management.
Several outstanding leaders from various scientific fields attended the initial meeting as consultant experts. Among them were Dai Tao, the deputy director of the Development Center for Medical Science and Technology of the National Health and Family Planning Commission of China, Jin Li, the vice-president of Fudan University, Li Peng, the director of the Life Sciences Department of the National Natural Science Foundation and vice president of Tsinghua University's School of Life Sciences, Zhang Xuemin, the director of the Medical Sciences Department of the National Natural Science Foundation and director of the Academy of Military Medical Science Institute of Pharmacology and Toxicology, Chen Runsheng, researcher at the Institute of Biophysics, Chinese Academy of Sciences, Gu Dongfeng, the deputy director of the National Center for Cardiovascular Diseases and vice president of the Chinese Academy of Medical Sciences Fuwai Hospital. Han Jiecai, vice president of HIT delivered the keynote address. More than 70 representatives from twenty institutions and biology information technology companies attended the meeting.
Wang Yadong is leader of this project. He is the principal scientist and president of HIT's School of Computer Sciences and Technology and the Institute of Biological Information Technology. He presented an overview of the project to those in attendance. Five of the project directors, Jin Li, Chen Runsheng, Li Peng, Zhang Xuemin and Gu Dongfeng, gave presentations on implementation plans. They lauded the objectives, prospects, contents and plans of this project. They offered constructive suggestions and comments on the implementation, critical technology and scientific challenges which may arise as part of future follow-up work.
This genome project will be divided into three phases. In the first phase, the first step is to build a demonstration project, in which genome sequencing of 10,000 Chinese people and the corresponding phenotype group and exposure group data collection will be completed. This requires genome mapping and health mapping of 10,000 people. Also included in the first phase is developing, optimizing and verifying several sets of advanced genome mutation analysis workflow, formulating quality control specifications for several sets of genome groups, and phenotype group and exposure group data collection. Forming flawless technical systems and engineering operating systems for the large population-based genome project will be required. The second phase is extremely crucial. 50,000 people's genome sequencing and phenotype data will be collected. Then, after integrating and analyzing the data, a genome map and health map for 60,000-people will be drawn. The technical systems and engineering operating systems will be continually optimized, accelerating the implementation of the project. The third phase is output. Genome sequencing and data collection analysis and integration and a 100,000-people genome map and health map will be completed. Technical systems and engineering operating systems will be further improved, providing critical reference for future scientific projects.
The launch meeting attracted extensive attention. It was reported by the CCTV News Broadcast, News in 30 Minutes, Eastern Times and other CCTV programs.
If you wish to view the reports here are their web locations:
Speech by Dai Tao, Deputy Director of the Development Center for Medical Science and Technology National Health and Family Planning Commission of China
Speech by Han Jiecai, HIT vice-president.
Report given by Wang Yadong, leader of the project
Discussion with five academicians
Group photo

subset: commoncrawl


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The use of neonicotinoid insecticides in agriculture is now recognized for the health risks it poses to non-target wildlife, with associated honey bee mortality especially concerning. Research directed toward the presence and effects of these pesticides on terrestrial vertebrates that consume neonicotinoid-coated seeds, such as wild turkeys (Meleagris gallopavo silvestris), is lacking. This study used liquid chromatography attached to a tandem mass spectrometer to assess the liver from 40 wild turkeys for neonicotinoid and other pesticide residues and compared detected levels of these contaminants across the southern Ontario, Canada. Nine (22.5%) wild turkeys had detectible levels of neonicotinoid residues—clothianidin in eight, and thiamethoxam in three. Two (5.0%) of these turkeys had detectable levels of both clothianidin and thiamethoxam. Fuberidazole was detected in two (5.0%) wild turkeys. The highest level of thiamethoxam detected was 0.16 ppm, while clothianidin was detected at 0.12 ppm, and fuberidazole at 0.0094 ppm. Knowledge of exposure in free-ranging wildlife is critical for better understanding the effects of neonicotinoids on wildlife health; thus, these data help establish baseline data for southern Ontario wild turkeys and provide context for reference values in future analyses. . . . . . . . Keywords Bioaccumulation Birds Insecticides Neonicotinoids Non-targetspecies Pesticides Treated seeds Wild Turkey Introduction used on many large-acreage crops in southern Ontario (e.g., corn, soy, grains, dry beans, and canola), 60% are utilized as Neonicotinoid insecticides (NNIs) have become the most seed coatings (Jeschke et al. 2011;OMNRF 2017). NNIs are widely used insecticides in the world (Schaafsma et al. systemic insecticides, taken up by the plant following appli- 2015). Commonly used in agriculture, they are applied as cation and distributed systemically through plant tissues as it various formulations including as foliage sprays, seed coating, grows. They act by affecting the central nervous system of and soil treatments. Of NNIs used globally, including those insects, causing over-excitation of nerve synapses, followed by paralysis and eventually death (Fishel 2013). Recently, these insecticides have been recognized for the risks they pose Responsible editor: Philippe Garrigues to non-target wildlife, including as a potential factor driving colony collapse disorder in honey bees (Farooqui 2013). However, little attention has been paid to higher trophic biota, * Amanda M. MacDonald email@example.com including terrestrial vertebrates. Wild turkeys (Meleagris gallopavo), and other avian spe- cies such as gray partridges (Perdix perdix) and pigeons Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON NIG 2W1, Canada (Columba palumbus, C. livia, and C. oenas), readily ingest treated corn or soya seeds (Mineau and Palmer 2013;Millot Canadian Wildlife Health Cooperative, Ontario Veterinary College, University of Guelph, Guelph, ON NIG 2W1, Canada et al. 2017); in fact, depending on food availability, these resources comprise a significant portion of the wild turkey's Environment and Climate Change Canada, Science and Technology Branch, National Wildlife Research Center, Ottawa, ON K1A 0H3, diet (OMNRF 2007). These seeds can contain some of the Canada highest concentrations of NNIs (Gibbons et al. 2015), making Present address: Southeastern Cooperative Wildlife Disease Study, them of particular concern because of their availability to birds University of Georgia, Athens, GA 30602, USA and the potential for repeat or ongoing exposure. A single corn Environ Sci Pollut Res (2018) 25:16254–16260 16255 16256 Environ Sci Pollut Res (2018) 25:16254–16260 Fig. 1 Map depicting the locations and pesticide compounds detected supernatant was cleaned with methanol and 0.1 M ammonium among 40 hunter-harvested wild turkeys collected during the 2015 spring acetate. Sample extracts were analyzed using LC-MS/MS op- hunt (April–May) in Ontario, Canada erated in electrospray ionization mode. kernel is typically treated with approximately 1 mg of active ingredient (Rexrode et al. 2003) and consumption of just one Results imidacloprid-treated corn seed, or a few clothianidin- or thiamethoxam-treated seeds, could be lethally toxic to a bird Of 40 wild turkey livers tested, all were male (due to hunter- the size of a blue jay (Mineau and Palmer 2013). The persis- harvest regulations), 3 were juveniles, and 37 were adults. tence of NNIs in the environment as well as their potential ill- NNI compounds were detected by LC-MS/MS in liver sam- ples from 17 wild turkeys (i.e., 43% of samples analyzed) at effects on non-target species remains unclear. Recently, there has been a great deal of public and political controversy and levels approaching the lower detection limit. In 6 of these samples, levels were higher than the lower detection limit media coverage regarding the use and associated risks of NNIs to honey bee health and mortality. There has also been grow- but still below quantification limits (BAppendix^ Table 2). Nine of 40 (22.5%) adult wild turkeys had detectible levels ing concern among natural resource managers, conservation- ists, and hunters about whether NNI use may be linked to poor of NNI residues, clothianidin in eight, and thiamethoxam in reproductive output of wild turkeys and potential bioaccumu- three. Two (5.0%) of these turkeys had detectable levels of lation of NNIs in wild turkey meat intended for human both clothianidin and thiamethoxam. Fuberidazole (a fungi- consumption. cide used as a seed treatment for cereals) was detected in two The present study was conducted to address knowledge (5.0%) wild turkeys. The highest levels detected for each com- gaps and the concerns described above. Samples originated pound were 0.16 ppm of thiamethoxam, 0.12 ppm of clothianidin, and fuberidazole at 0.0094 ppm (Table 1). from healthy-appearing, hunter-harvested wild turkeys from across southern Ontario. The objectives were to (1) assess wild turkey liver tissues for NNIs and other potential environ- mental contaminants and (2) compare levels of detected con- Discussion taminants across the geographic area of the study site. Neonicotinoids are insecticides used worldwide in agriculture as seed treatments on crops such as corn and soya (Garthwaite et al. 2003; Jeschke et al. 2011). This class of pesticide in- Materials and methods cludes acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, nithiazine, thiacloprid, and thiamethoxam. During the 2015 Ontario spring hunting season (April–May), Imidacloprid, clothianidin, and thiamethoxam are the most 147 hunter-harvested wild turkey carcasses were collected common NNIs applied for agricultural use in Ontario (Wildlife Scientific Collector's Authorization from the (Somers and Chung 2014). Wild turkeys in Ontario and other Ontario Ministry of Natural Resources and Forestry, regions live within concentrated areas used for agriculture and #1079555) from across southern Ontario. Carcasses were often rely on croplands for supplemental feeding to survive, stored at − 20 °C and thawed at 4 °C prior to sample collec- particularly in winter months (Porter et al. 1980; Vander tion. Liver samples from each turkey were collected and Haegen et al. 1989). Thus far, NNIs have been best known stored at − 80 °C until testing. Forty samples were selected for the adverse effects they cause in honey bees. Mass die- to represent regions across the collection range (Fig. 1)and offs, and subsequent declines in bee population numbers, have were sent for pesticide residue analysis at Laboratory garnered widespread attention and concern in recent years Services, Agriculture and Food Laboratory, University of because of the importance of bees in providing a vital ecosys- Guelph, Guelph, Ontario. The testing proceeded using liquid tem service, namely, pollination (Whitehorn et al. 2012; chromatography attached to a tandem mass spectrometer (LC- Godfray et al. 2015; Rundlöf et al. 2015). MS/MS). The TOPS-142 screening procedure included the Pesticides, including the NNIs clothianidin and analysis and quantification of 142 different pesticide com- thiamethoxam, were detected in the liver of nearly half of wild pounds, including seven neonicotinoids (Wang and Leung turkeys tested. These turkeys were likely exposed to NNIs by 2009). consuming pesticide-coated seeds during crop sowing that Extraction of pesticides from wet turkey livers was per- spring, as treated seeds were observed in the crops of several formed using the QuEChERS method (Anastassiades et al. birds at the time of necropsy. Although accumulated residues 2003). Briefly, each sample was extracted using 1% acetic were low, evidence is mounting that non-target avian species, acid in acetonitrile and liquid phases were partitioned using such as partridges, pigeons, and quail (Colinus virginianus, sodium acetate and anhydrous magnesium sulfate. The Coturnix japonica), are exposed through the consumption of Environ Sci Pollut Res (2018) 25:16254–16260 16257 Table 1 Summary of detectible Pesticide Main use No. of turkeys (%) MDL (ppm) Range (ppm) levels of pesticide residues in livers of hunter-harvested wild turkeys Clothianidin Insecticide 8 (20.0) 0.001 0.0086–0.1200 (n = 40) in April–May 2015, from Ontario, Canada Thiamethoxam Insecticide 3 (7.5) 0.001 0.0110–0.1600 Fuberidazol Fungicide 2 (5.0) 0.0005 0.0077–0.0094 MDL minimum detection limit these coated seeds (Mineau and Palmer 2013; Millot et al. consuming approximately 4 imidacloprid-treated canola 2017). Recently, concentrations up to 0.067 mg/kg of seeds, or just 0.2 treated corn seeds (i.e., dosage of 4.1 μg thiamethoxam/clothianidin were reported in failed eggs of imidacloprid/g bw/day, equivalent to 10% of the LD of gray partridge known to frequent pesticide-treated cereal house sparrows; Eng et al. 2017). fields in north-central France (Bro et al. 2016). Very little Additional research is required to determine the chronic published information is available on fuberidazole in non- health and reproductive effects on wild turkeys and other target species; however, it was suspected to have played a role wildlife that may occur with repeated exposure and ingestion in the morbidity observed in pheasants feeding on treated of NNI-coated seeds. For example, knowledge gaps exist on wheat within a game farm in the UK (Laing 2001). the timing and duration of exposure, the rate at which these Most experimental pesticide toxicity studies are limited to chemicals are metabolized in birds, and what proportion of the observations of acute toxicity in laboratory rats, even though ingested material reaches the liver. Such information will re- birds are often more susceptible than rats to pesticide toxicity. quire both field studies to understand wildlife feeding habits These laboratory assessments often target single compounds, and behavior and experimental studies to delineate toxic levels when in reality, non-target wildlife species are exposed to com- and associated clinical effects. It should be noted that studies plex mixtures of pesticides/contaminants with synergistic and/ such as ours also carry inherent sampling biases. First, we or inhibitory effects. Such laboratory studies also neglect to relied on sampling of hunter-harvested wild turkeys, which consider species-specific sensitivities to single compounds, or tend to be skewed toward larger, healthy-appearing male complex mixtures that could ultimately impair whole popula- birds. Also, wild turkeys that may be suffering from morbidity tions. For example, clothianidin, which was detected in 20% of or mortality associated with NNI ingestion are less likely to be wild turkeys in the present study, is considered far less toxic to recovered and tested, as they may hide in vegetation prior to rats (LD > 5000 mg/kg) compared to Japanese quail (423 mg/ death or be killed and consumed by predators. kg) and northern bobwhite quail (> 2000 mg/kg). The LD of Little is known about NNI persistence and impacts on non- imidacloprid in rats ranges from 379 to 648 mg/kg (or ppm), target avian species in agricultural landscapes. As of July 1, but this dose is much lower for birds: 14 mg/kg for gray par- 2015, new regulatory requirements came into effect for the tridge, 31 mg/kg for Japanese quail, and 152 mg/kg for north- sale and use of NNI-treated seeds in Ontario. These require- ern bobwhite quail (SERA 2005; Anon 2012; Rose 2012; ments support reducing the use of imidacloprid, Mineau and Palmer 2013). Currently available toxicity data thiamethoxam, and clothianidin on specific crops (corn and often disregard the chronic effects of exposure, which may soybean) planted with NNI-treated seeds by 80% by 2017; occur at lower concentrations and over longer periods of time however, only an estimated 25% reduction has been reported in free-ranging wildlife or other animals. For example, a dose based on 2014 baseline data (MOECC 2015). Knowledge of equivalent to 0.10% of a neonicotinoid-coated corn seed chronic and acute bird exposure, particularly in farmland ingested daily during the egg-laying season can adversely af- birds, should be a first step in understanding the effects of fect reproduction in birds (Mineau and Palmer 2013). NNIs on the health of birds and other wildlife. These data Although not detected in the present study, imidacloprid is are important to serve as baseline data for southern Ontario considered the most toxic NNI in birds (EPA 2016), although wild turkeys and to provide context for reference values in toxicity varies across species. For example, a study involving future analyses. pigeons and partridges found dead in a barn following expo- Acknowledgements We would like to thank Pud Hunter for valuable sure to coated seeds showed hepatic toxicity levels of advice and logistical support, in addition to Dave Snook, Aylmer imidacloprid ranging from 1.0–1.6 μg/g (ppm) in partridges District Stakeholders Committee, Kathy Moore, Brian Moore, Tony and up to 3.1 μg/g in pigeons (Berney et al. 1999). Recent Jackson, Felix Barbetti and the hunters for providing samples. experimental research on the migratory white-crowned spar- row (Zonotrichia leucophrys) in Saskatchewan, Canada, Funding information This research was funded by the Ontario Ministry of Agriculture, Food, and Rural Affairs–University of Guelph Partnership showed that delays in and impaired orientation during migra- (No. 2013-1530) and was further supported by the Ontario Federation of tion, loss of body mass, decreased reproduction efforts, and Anglers and Hunters, Zone J, and its members. potentially increased mortality are possible outcomes after 16258 Environ Sci Pollut Res (2018) 25:16254–16260 Appendix Table 2 Pesticide residue testing results from livers of 40 hunter-harvested wild turkeys in April–May 2015, from Ontario, Canada Neonicotinoid (ppm) Other (ppm) Sample Acetamiprid Clothianidin Dinotefuran Imidacloprid Nitenpyram Thiabendazole Thiacloprid Thiamethoxam Fuberidazol Mandipropamid MDL (ppm) 0.001 0.001 0.002 0.001 0.001 0.0005 0.001 0.001 0.0005 0.0005 1 N.D. N.D. N.D. N.D. N.D. < MDL N.D. N.D. N.D. N.D. 2 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 3 N.D. N.D. N.D. N.D. N.D. < MDL N.D. N.D. N.D. N.D. 4 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 5 N.D. 0.11 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 6 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. < MDL N.D. 7 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 8 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 9 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 10 N.D. 0.0091 N.D. N.D. N.D. N.D. N.D. < MDL N.D. N.D. 11 N.D. < MDL N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 12 N.D. < MDL N.D. N.D. N.D. N.D. N.D. 0.011 < MQL N.D. 13 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 14 N.D. < MDL N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 15 N.D. 0.069 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 16 N.D. < MDL N.D. N.D. N.D. < MDL N.D. N.D. N.D. N.D. 17 N.D. < MQL N.D. N.D. N.D. N.D. N.D. < MQL N.D. N.D. 18 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. < MDL 19 N.D. < MDL N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 20 N.D. < MQL N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 21 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 22 N.D. < MDL N.D. N.D. N.D. N.D. N.D. N.D. < MDL N.D. 23 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 24 N.D. 0.0089 N.D. N.D. N.D. < MDL N.D. < MQL N.D. N.D. 25 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 26 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 27 N.D. 0.026 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 28 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 29 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 30 N.D. 0.023 N.D. N.D. N.D. N.D. N.D. 0.16 N.D. < MDL 31 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Environ Sci Pollut Res (2018) 25:16254–16260 16259 Table 2 (continued) Neonicotinoid (ppm) Other (ppm) Sample Acetamiprid Clothianidin Dinotefuran Imidacloprid Nitenpyram Thiabendazole Thiacloprid Thiamethoxam Fuberidazol Mandipropamid MDL (ppm) 0.001 0.001 0.002 0.001 0.001 0.0005 0.001 0.001 0.0005 0.0005 32 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 33 N.D. 0.0086 N.D. N.D. N.D. N.D. N.D. 0.016 N.D. N.D. 34 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 35 N.D. < MDL N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 36 N.D. 0.12 N.D. N.D. N.D. < MDL N.D. N.D. N.D. N.D. 37 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 0.0094 N.D. 38 N.D. N.D. N.D. N.D. N.D. < MQL N.D. N.D. 0.0077 N.D. 39 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 40 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. not detected, <MDL less than minimum detection limits, <MQL less than minimum quantification limits 16260 Environ Sci Pollut Res (2018) 25:16254–16260 Open Access This article is distributed under the terms of the Creative Millot F, Decors A, Mastain O, Quintaine T, Berny P, Vey D, Lasseur R, Commons Attribution 4.0 International License (http:// Bro E (2017) Field evidence of bird poisonings by imidacloprid- creativecommons.org/licenses/by/4.0/), which permits unrestricted use, treated seeds: a review of incidents reported by the French SAGIR distribution, and reproduction in any medium, provided you give network from 1995 to 2014. Environ Sci Pollut Res 24:5469–5485 appropriate credit to the original author(s) and the source, provide a link Mineau P, Palmer C (2013) The impact of the Nation's most widely used to the Creative Commons license, and indicate if changes were made. insecticides on birds: neonicotinoid insecticides and birds. American Bird Conservancy, USA MOECC (Ontario Ministry of the Environment and Climate Change) (2015) Neonicotinoid regulations for seed vendors. https://www. ontario.ca/page/neonicotinoid-regulations-seed-vendors#section-5. References Accessed 05 February 2018 OMNRF (Ontario Ministry of Natural Resources and Forestry) (2007) Wild turkey management plan for Ontario. Ministry of Natural Anastassiades M, Lehotay SJ, Stajnbaher D, Schenck FJ (2003) Fast and Resources and Forestry, Ottawa easy multiresidue method employing acetonitrile extraction/ partitioning and Bdispersive solidphase extraction^ for the determi- OMNRF (Ontario Ministry of Natural Resources and Forestry) (2017) nation of pesticide residues in produce. J AOAC Int 86:412–431 Neonicotinoids and field crop production in Ontario. http://www. Anon (2012) Addendum 7 to the draft assessment report; confirmatory omafra.gov.on.ca/english/about/beehealthpresentations/omafcrop. data; imidacloprid. EU Commission htm. Accessed 15 November 2017 Berney PJ, Buronfosse F, Videmann B, Buronfosse T (1999) Evaluation Porter WF, Tangen RD, Nelson GC, Hamilton DA (1980) Effects of corn of the toxicity of imidacloprid in wild birds. A new high perfor- food plots on wild turkeys in the upper Mississippi Valley. J Wildl mance thin layer chromatography method for the analysis of liver Manag 44:456–462 and crop samples in suspected poisoning cases. J Liq Chromatogr Rexrode M, Barrett M, Ellis J, Gabe P, Vaughan A, Felkel J, Melendez J Relat Technol 22:1547–1559 (2003) EFED risk assessment for the seed treatment of clothianidin Bro E, Devillers J, Millot F, Decors A (2016) Residues of plant protection 600FS on corn and canola. United States. Environmental Protection products in grey partridge eggs in French cereal ecosystems. Agency, Washington, DC Environ Sci Pollut Res 23:9559–9573 Rose PH (2012) Nicotine and the neonicotinoids. In: Mars T (ed) Eng ML, Stutchbury BJM, Morrissey CA (2017) Imidacloprid and chlor- Mammalian toxicology of insecticides. Royal Society of pyrifos insecticides impair migratory ability in a seed-eating song- Chemistry, pp 184–220 bird. Sci Rep 7:15176 Rundlöf M, Andersson GKS, Bommarco R, Fries I, Hederström V, EPA (United States Environmental Protection Agency) (2016) EPA pesti- Herbertsson L, Jonsson O, Klatt BK, Pedersen TR, Yourstone J, cide toxicity categories. EPA label review manual. http://www.epa.gov/ Smith HG (2015) Seed coating with a neonicotinoid insecticide oppfead1/labeling/lrm/chap-07.htm#IIIA. Accessed 14 January 2018 negatively affects wild bees. Nature 521:77–80 Farooqui T (2013) A potential link among biogenic amines-based pesti- Schaafsma A, Limay-Rios V, Baute T, Smith J, Xue Y (2015) cides, learning and memory, and colony collapse disorder: a unique Neonicotinoid insecticide residues in surface water and soil associ- hypothesis. Neurochem Int 62:122–136 ated commercial maize (corn) fields in southwestern Ontario. PLoS Fishel FM (2013) Pesticide toxicity profile neonictinoid pesticides IFAS One 10(2):e0118139 Ext.; Publication PI-80; IFAS Extension, Pesticide Information SERA (2005) Imidacloprid—human health and ecological risk assess- Office, Florida Cooperative Extension Service, Institute of Food ment—final report. Report from Syracuse Environmental Research and Agricultural Sciences, University of Florida Associates to USDA, Forest Service Garthwaite DG, Thomas MR, Dawson A, Stoddart H (2003) Pesticide Somers N, Chung R (2014) Ontario Agency for Health Protection and Usage Survey Report 187: arable crops in Great Britain 2002. Promotion (Public Health Ontario) case study: neonicotinoids. Department for Environment, Food and Rural Affairs, London Queen's Printer for Ontario, Toronto Gibbons D, Morrissey C, Mineau P (2015) A review of the direct and Vander Haegen MW, Sayre MW, Dodge WE (1989) Winter use of agri- indirect effects of neonicotinoids and fipronil on vertebrate wildlife. cultural habitats by wild turkeys in Massachusetts. J Wildl Manag Environ Sci Pollut Res 22:103–118 53:30–33 GodfrayHCJ,BlacquièreT,Field LM,Hails RS,Potts SG,Raine NE, Wang J, Leung D (2009) Determination of 142 pesticides in fruit and Vanbergen AJ, McLean AR (2015) A restatement of recent advances vegetable based infant foods by liquid chromatography/ in the natural science evidence base concerning neonicotinoid insec- electrospray ionization-tandem mass spectrometry and estimation ticides and insect pollinators. Proc R Soc B 282:1821 of measurement uncertainty. J AOAC Int 92:279–301 Jeschke P, Nauen R, Schindler M, Elbert A (2011) Overview of the status and global strategy for neonicotinoids. J Agric Food Chem 59: Whitehorn PR, O'Connor S, Wackers FL, Goulson D (2012) 2897–2908 Neonicotinoid pesticide reduces bumble bee colony growth and Laing PW (2001) Possible bitertanol and fuberidazole poisoning in young queen production. Science 336:351–352 pheasants. Vet Rec 149:118–120
Environmental Science and Pollution Research – Springer Journals
Published: Apr 27, 2018
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Extensions with the CLI
Extensions are built and managed within a Contentful space through the Content Management APIs
extension endpoint. To make it more convenient, the Contentful CLI supports managing the extensions.
Create a new UI Extension
To get started, install the Contentful CLI.
npm install -g contentful-cli
Following is the step by step procedure to build a UI Extension (Vanilla HTML5 UI Extension template) from scratch.
1. Authentication
To authenticate, following are required:
ID of the space, where the extensions are used.
A valid CMA token (obtaining a token).
2. Building an Extension
- Start with building the
Ensure that the
index.html file includes:
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<!DOCTYPE html>
<meta charset="utf-8">

<link rel="stylesheet" href="https://contentful.github.io/ui-extensions-sdk/cf-extension.css">

<input type="text" class="cf-form-input">

I am a UI Extension.

Instance params:

Installation params:

'use strict';
// When UI Extensions SDK is loaded the callback will be executed.
function initExtension (extensionsApi) {
// "extensionsApi" is providing an interface documented here:
// https://github.com/contentful/ui-extensions-sdk/blob/master/docs/ui-extensions-sdk-frontend.md
// Automatically adjust UI Extension size in the Web App.
var inputEl = document.querySelector('.cf-form-input');
// The field this UI Extension is assigned to.
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// Callback for changes of the field value.
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// Handle keyboard input.
inputEl.addEventListener('input', keyboardInputHandler);
// Handle DOM "onbeforeunload" event.
window.addEventListener('onbeforeunload', unloadHandler);
// Handler for external field value changes (e.g. when multiple authors are working on the same entry).
function valueChangeHandler (value) {
inputEl.value = value || '';
// Event handler for keyboard input.
function keyboardInputHandler () {
var value = inputEl.value;
if (typeof value !== 'string' || value === '') {
} else {
// Event handler for window unload.
function unloadHandler () {
window.removeEventListener('onbeforeunload', unloadHandler);
inputEl.removeEventListener('input', keyboardInputHandler);
index.html file is now ready to use. Refer to Vanilla HTML5 UI Extension template to understand more about how the code is organized.
3. Uploading an Extension to Contentful
Hosting Options
- Internally hosted: The extension's source code is uploaded to Contentful as a bundled string where all local dependencies need to be inlined into one single file. Internal extensions are uploaded by using the
srcdocproperty and have a limit of 200kb. Use internal hosting if you don't want to host anything on your own and can accept the drawbacks (need for a non-standard build, file size limitation).Note: Internal hosting is not supported on Internet Explorer and Microsoft Edge.
For example,
"id": "foo-extension",
"fieldTypes": ["Symbol", "Text"],
"name": "My wonderful foo extension",
"sidebar": false,
"srcdoc": "./dist/bundle.html"
- Third party hosted The extension's source code is uploaded to a third party server by using the
srcproperty. Relative links in the root HTML are supported as expected. Any platform (such as S3, Heroku, personal corporate server, etc) is supported, provided it supports CORS policy and is available through HTTPS.
Use third party hosting when you want to be as flexible as possible with your development and deployment process.
For example,
"id": "foo-extension",
"fieldTypes": ["Symbol", "Text"],
"name": "My wonderful foo extension",
"sidebar": false,
"src": "https://foo.com/extension"
Descriptor Files
The properties of an extension can be stored in a descriptor JSON file. The descriptor file can be passed to the CLI so the properties don't have to be provided individually.
Following is an example of a descriptor file:
"id": "extn",
"name": "Vanilla HTML5 UI Extension template",
"src": "./index.html",
"fieldTypes": ["Text"]
To make Contentful aware of the extension, navigate to the folder with the extension code and register the extension with the Contentful CLI:
$ contentful extension create --space-id $SPACE
If the extension is modified, use the
update sub-command to push the changes to Contentful:
contentful extension update --space-id $SPACE --force
4. Testing from a Local Development Environment
Testing the extension on a local environment provides a preview to the changes without deploying it.
To test the extension on the local environment:
Run the extension on a local server as follows:
python -m SimpleHTTPServer 3000
The extension is available at http://localhost:3000/.
Update the extension again by overriding its
srcvia the following command:
contentful extension update --space-id $SPACE --force \ --src http://localhost:3000/
Note: As Contentful runs in an HTTPS environment, temporarily disable the security checks in the browser. For example, "Load unsafe scripts" in Chrome.
Post debugging, redeploy the extension without the
src argument override to let it run from Contentful's servers or any other external hosting solution.
5. Configuring a field to use an extension
Refer the section Assigning UI Extensions to a Field to assign the extension to the particular field where it needs to be used.
Managing UI Extensions
contentful extension is composed of the following five subcommands that are used to manage extensions:
- Create - Creates an extension for the first time.
contentful extension create [options]
- Update - Modifies an existing extension.
contentful extension update [options]
- Delete - Permanently deletes an extension.
contentful extension delete [options]
- Read - Reads the extension payload from Contentful.
contentful extension read [options]
- List - Lists all the extensions created for the given space.
contentful extension list [options]
To learn how these commands work in CLI, refer the CLI documentation or use inline help of the CLI:
contentful extension --help
Version Locking
Contentful uses optimistic locking to avoid accidental non-idempotent operations such as
update or
While using the
update and
delete subcommands, it is mandatory to specify the version of the extension using the
--version option. Alternatively, the
--force option can be used that instructs the CLI to use the latest version of the extension.
Programmatic Usage
To manage an extension programmatically, refer the Content Management SDKs.
Next steps
Not what you're looking for? Try our FAQ.


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Sophia Siddiqui
Chief of Army Staff Gen Qamar Bajwa on Friday confirmed the death sentence awarded to 13 hardcore terrorists, who were involved in heinous offences related to terrorism, and killing of innocent civilians, officials of law-enforcement agencies and the armed forces.
According to Inter-Services Public Relations (ISPR), the terrorists planned and executed attacks at Bacha Khan University Charsada, Parade Lane Mosque Rawalpindi, Marriot Hotel Islamabad, office of the NGO World Vision at Mansehra and educational institutions at Nawagai in Buner.
"On the whole, they were involved in killing 325 persons and causing injuries to 366 others," the ISPR statement said, adding that explosives and fire-arms were also recovered from them. These convicts who belonged to proscribed outfits, were also tried by military courts.
Wahid Ali, Akbar Ali, Muhammad Riaz and Noor Ullah were involved in attack at Bacha Khan University on January 20 this year, which had resulted in the death of 17 civilians and injuries to 19 others.
They were also found in possession of fire arms and explosives. These convicts had confessed their offences before the magistrate and the trial court.


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.Net Framework Web Developer
Job Description
|Reference # :
|Title :
|.Net Framework Web Developer
|Location :
|West Nyack, NY
|Position Type :
|Experience Level :
|6 Years
|Start Date / End Date :
|10/17/2017 / 06/30/2018
|Assignment Detail
.Net Framework Web Developer
Want to be part of the Energy Industry? Eclaro is looking for a .Net Framework Web Developer for our client in West Nyack, NY.
Eclaro's client operates one of the world's largest energy delivery systems, constantly at the forefront of innovations in developing technology. If you're up to the challenge, then take a chance at this rewarding opportunity!
The responsibilities of a .Net Framework Web Developer is to analyze, perform code reviews, code, and test solutions for upgrading the O&R Substation Information System from a client server to a .net web application, while following corporate standards. Comprehensive test cases and system documentation are required. The assignment will begin in early November 2017 for approximately 9-11 months.
If hired, you will enjoy the following Eclaro Benefits:
Interested in applying?
Contact Henry Zuniga at firstname.lastname@example.com now.
Equal Opportunity Employer: Eclaro values diversity and does not discriminate based on Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status.
Application Instructions
Please click on the link below to apply for this position. A new window will open and direct you to apply at our corporate careers page. We look forward to hearing from you!Apply Online
Posted: 11/14/2018
Job Status: Contract/Temporary


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Hunger Around the World
Jasmine Flores
What's The Problem?
Sadly, people all around the world are suffering with an empty stomach, hunger. Places like Asia, Africa, and other developing countries are going hungry. More then 145,000 children are underweight or born underweight due to not having food. Woman are giving birth to underweight children because they cant provide enough nutrition to themselves. Most woman die during child birth because they don't consume enough iron to give birth. These people are continuing their lives like this on a daily basis, living on a grain of rice a day. Its time to make a difference.
How can We Help?
The cause of this worldwide issue in mainly poverty. Majority of the people living with hunger are also living with poverty, making it hard to have the money to buy food. The farmers in developing countries usually can't afford seeds and when they can they might not receive enough rain to grow their crops. People can donate money to certain charities that can help this problem. There are also food drives that send canned food and some boxed food items to the people living with hunger. In the end it all comes down to selflessness and donating to the others who aren't as fortunate.
Rising Food Prices - Nearly One Billion Go to Bed Hungry


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Globalization and the National Security State
T. V. Paul, Norrin M. Ripsman
Editore: Oxford University Press Inc
Anno: 2010
Rilegatura: Paperback / softback
Pagine: 296 p.
Testo in English
Dimensioni: 234 x 154 mm
Peso: 424 gr.
Articolo acquistabile con 18App e Carta del Docente
Approfitta delle promozioni attive su questo prodotto:
€ 21,41€ 25,19
Risparmi € 3,78 (15%)
Venduto e spedito da IBS
21 punti Premium
Disponibile in 10 gg
Questo articolo potrebbe non essere consegnato entro Natale
In the past two decades, many have posited a correlation between the spread of globalization and the decline of the nation-state. In the realm of national security, advocates of the globalization thesis have argued that states' power has diminished relative to transnational governmental institutions, NGOs, and transnational capitalism. Initially, they pointed to declines in both global military spending (which has risen dramatically in recent years) and interstate war. But are these trends really indicative of the decline of nation-state's role as a guarantor of national security? In Globalization and the National Security State, T.V. Paul and Norrin Ripsman test the proposition against the available evidence and find that the globalization school has largely gotten it wrong. The decline in interstate warfare can largely be attributed to the end of the Cold War, not globalization. Moreover, great powers (the US, China, and Russia) continue to pursue traditional nation-state strategies. Regional security arrangements like the EU and ASEAN have not achieved much, and weak states - the ones most impacted by the turmoil generated by globalization - are far more traditional in their approaches to national security, preferring to rely on their own resources rather than those of regional and transnational institutions. This is a bold argument, and Paul and Ripsman amass a considerable amount of evidence for their claims. It cuts against a major movement in international relations scholarship, and is sure to generate controversy.


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Gozo Youth Council
The Gozo Youth Council is an umbrella organisation that gathers the youths and youth organisations present in the island region of Gozo.
The council provides a forum of dialogue for young people and a channel of information and opinions between young people and decision makers. In all, it is a representative body of young people's interests and of Gozo and a strong voice on a regional, national, European and international level.
The mission of the Gozo Youth Council is to provide a national forum for youths and youth organisations in Gozo to effectively develop, promote and advocate youth initiatives and policy making in the youth field.
The GYC also tackles young people's challenges whilst living on islands, and empowers their active participation in the future of our global society.
The Council also advocates society's connection with nature, the link between education and job opportunities, as well as the economical and entrepreneurial challenges that translate to opportunities.
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Rasa – Alonzo King LINES Ballet
By Alonzo King LINES Ballet
Alonzo King LINES Ballet performs Rasa, with live tabla music by Zakir Hussain and Kala Ramnath.
The original score by tabla virtuoso Hussain, was called "an intriguing wonder" by the New York Times. Rasa is both a continuation of a deep Indian tradition–the interdependence of dance and tabla music as art forms–and an expression of the contemporary global vision of both Hussain and LINES Ballet.
Recorded in Fall 2014 at the Yerba Buena Center for the Arts in San Francisco.


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The FTSE 100 has breached 5,500 today as investors' concerns about the health of the eurozone continue to grow.
At 16.12, the FTSE 100 stood at 5463.06 a fall of 2 per cent. Markets across Europe also fell with the German Dax and the French Cac 40 down 2 and 2.2 per cent respectively.
Investor attention remains fixed on the eurozone, as talks over the weekend to form a new government in Greece appear to have failed and the country is likely to return to the ballot box. There are also renewed concerns of Greece leaving the euro.
Barclays was the biggest faller in the FTSE 100, having seen over 6 per cent wiped off its share price.


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