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Flashcards in Lecture 1 & 2 Deck (33):
Classify endocrine glands based on chemical components of their secretion.
Steroids: gonadal & adenocortical steroids
Small peptides, polypeptide, & proteins: insulin, glucagon, GH, LH, ACTH
Amino acids and Arachiodonic Acid analogs & deriv: catecholamines, PGs, prostacyclin, and leukotrienes (thyroid hormones)
Describe common histological characteristics
of all endocrine glands.
- ductless
- cords of cells invested in reticular fibers
- fenestrated capillaries (may be called sinusoids)
- secrete hormones that act on target organs
Describe the development of the pituitary gland.
anterior lobe:
- evagination of ectoderm of oropharynx
- 3 derivatives of Rathke's pouch:
1. par distalis: anterior wall of pouch
2. pars intermedia: posterior wall of pouch
3. pars tuberalis: lateral walls of pouch
posterior lobe:
- downgrowth (embryonic infundibulum) of neuroectoderm of the floor of the diencephalon (3rd ventricle)
- 2 parts:
1. pars nervosa
2. infundibulum
Identify & describe the glandular and nervous tissue components of the pituitary gland
Anterior lobe: glandular tissue (Adenohypophysis)
- pars tuberalis
- pars distalis
- pars intermedia
Posterior lobe: neural tissue (Neurohypophysis)
- mediam eminence
- infundibulum
- pars nervosa
State the significance of hypothalamo-hypophyseal portal system.
provides crucial link between the hypothalamus and pituitary gland. System carries the neuroendocrine secretions from their site of release in mediam eminence and infundibulum directly to the cells of the pars distalis.
Identify & describe the microscopic structures of anterior and posterior pituitary.
Anterior pituitary (cellular):
- Chromophobes: unknown
- Chromophils:
Acidophils: somatotropes (GH; inhibited by somatostatin) & mammotropes (PRL; inhibited by dopamine)
Basophils:(B-FLAT) gonadotropes (FSH & LH), corticotropes (ACTH), & thyrotropes (TSH)
- production of alpha-MSH
- colloid filled cystic cavities
- basophilic cuboidal cells
Posterior pituitary (neurohypophysis):
- Herring bodies: release hormones into blood stream
- Pituicytes
- Fenestrated capillaries
-supraoptic nucleus: production of ADH
paraventricular nucleus: production of oxytocin
List the hormones produced by the cells of anterior pituitary and describe the major functions.
FLAT PiG
Follicle stimulating hormone (FSH): stimulates follicular development in the ovary and spermatogenesis in the testis
Luteinizing hormone (LH): regulates final maturation of ovarian follicle, ovulation, and corpus luteum; in males, essential for maintenance and secretion of adrogen secretion by Leydig cells
Adrenocorticotropic hormone (ACTH): maintains structure and stimulates secretion of glucocorticoids and gonadocorticoids by zona fasciculata and zona reticularis of adrenal cortex
Thyrotropic hormone (TSH): stimulates growth of thyroid epithelial cells; stimulates production and release of thyroglobulin and thyroid hormones
Prolactin (PRL): promotes mammary gland development; initiates milk formation; stimulates and maintains secretion of casein, lactalbumin, lipids, and carbohydrates into milk
Growth hormone (GH): stimulates liver and other organs to synthesize and secrete insulin-like growth factor I, which stimulates division of progenitor cells in growth plates and in skeletal muscle
Identify & describe the structure and functions of the pars intermedia.
- surrounds a series of small cystic cavities, colloid-filled follicles (residual Rathke's pouch)
- basophilic cuboidal cells: production of MSH
-unclear function
Identify & describe the components of posterior pituitary.
- contains non-myelinated axons and their nerve endings (neurosecretory neurons); cell bodies lie within supraoptic nuclei and paraventricular nuclei
- axons form hypothalamophyseal tract
- connects posterior lobe to hypothalamus
List the hormones that are stored in the posterior pituitary, their origin and their effects.
- synthesized in paraventricular nuclei
- acts on uterine contractions and millk release
- synthesized in supraoptic nuclei
- increases permeability of renal collecting tubule to water and vasoconstricts
State the significance of pituicytes and Herring bodies.
Pituicyte: only cells specific to posterior lobe of pituitary gland; specialized glial cells containing intermediate filament protein, charateristic of astrocytes
Herring bodies: dilations of unmyelinated axons containing secretory granules
Describe the blood supply to the pituitary gland.
Superior hypophyseal arteries: arises from internal carotid arteries and posterior communicating arteries of circle of Willis; supplies the pars tuberalis, median eminence, and infundibulum
Inferior hypophyseal arteries: arise from internal carotid artieries; supplies pars nervosa
superior hypophyseal arteries --> fenestrated capillaries (primary capillary plexus) --> hypophyseal portal veins --> second fenestrated capillary network --> cavernous sinus at base of diencephalon --> systemic circulation
- direct communication between hypothalamus and posterior pituitary
- communication between anterior pituitary and hypothalamus is via portal system
Describe the anatomical location and blood supply to the adrenal gland.
Located at superior poles of kidneys.
Blood supply: superior, middle, and inferior suprarenal arteries --> branching before entering capsule --> capsular capillaries, fenestrated cortical sinusoidal capillaries, and medullary arterioles --> adrenomedullary collecting veins --> central adrenomedullary vein --> IVC
Identify and describe the cortical zones of adrenal gland, hormones produced there and their function
superficial to deep: (GFR)
Zona Glomerulosa: thin, most superficial layer; globular arrangement
- aldosterone: electrolyte and water balance
Zona Fasciculata: thick, longitudinal columns arrangement
Zona Reticularis: trabeculae-like arrangement
Z. Fas. & Z. Ret. produce cortisol and androgens (DHEA): increase protein, carbohydrate, and fat metabolism and suppress immune function
Identify and describe
the adrenal medulla, hormones produced there and their function.
Chromaffin cells:
- modified post-ganglionic neurons; no axons/dendrites
- secrete catecholamines
Ganglion cells:
- axonal processes extend into cortex and modulate secretion
Describe the anatomical location and blood supply to pancreas
Location: retroperitoneal of abdomen.
Blood supply:
- Supplied by the pancreatic branches of the splenic artery.
- Head is additionally supplied by the superior (from celiac trunk) and inferior pancreaticoduodenal arteries (superior mesentery)
- Venous drainage of the head of the pancreas is into the superior mesenteric branches of the hepatic portal vein.
- Pancreatic veins draining the rest of the pancreas into the splenic vein.
List & describe the functional cell types of the endocrine pancreas.
alpha cells: located peripherally; secrete glucagon.
beta cells: located centrally; secrete insulin.
delta cells: scattered throughout; secrete gastrin and somatostatin
List the hormones produced by cells of endocrine pancreas and describe their effect
Glucagon: stimulation of glycogenolysis and glucose release from liver (glucogenesis), and lipolysis
Insulin: stimulates glycogenesis and glycolysis
Identify & describe the structure and function of the thyroid gland.
- butterfly shaped (isthmus) in the anterior of the neck, anterior to upper part of trachea
- capsule covered with CT that sends trabeculae into the parenchyma
- secretion of T3/ T4
- thyroid follicles is the functional unit of the gland
Describe the storage and secretory mechanisms of thyroid hormones.
Thyroid follicles:
- thyroid epithelium follicular cells (principal cells): simple cuboidal with apex towards colloid and BSM towards exterior; production of thyroid hormones T3 & T4: regulation of cell and tissue basal metabolism and heat production and influence body growth and development); short microvilli, endocytotic vesicles (colloidal resorption droplets), and lysosomes at apex for secretion and absorption; numerous rER at basal region
- colloid: thyroglobulin (inactive hormone; consists of triiodothyronine and tetraiodothyronine (or thyroxine)); secretory product of follicular cell.
Identify & describe the function and localization of parafollicular cells.
- Parafollicular cells (C cells):
at periphery of follicular epithelium; secrete calcitonin (regulation of serum calcium levels via inhibition of resorptive action of osteoclasts and promotes deposition in bones by increasing rate of osteoid calcification)
Identify & describe the structure and function of the parathyroid gland.
Location: 4 small glands embedded into the posterior part of the thyroid gland.
Function: secretion of PTH, which stimulates osteoclasts to release calcium from bone and uptake of calcium from intestines and kidneys.
- chief cells: secretion of PTH
- oxyphil cells: unknown function
Identify & describe the location, structure, and function of the pineal gland.
Location: posterior wall of the 3rd ventricle near the center of the brain
Function: endocrine/neuroendocrine gland that regulates daily body rhythm via photosensitivity; obtaining information of light and dark cycles from retina (retinohypothalamic tract: connects suprachiasmatic nucleus with sympathetic neural tracts traveling into pineal gland)
- flattened, pine cone-shaped
- pinealocytes
- interstitial (glial) cells
- corpora arenacea/brain sand
List the hormone produced by the pineal gland and its effect on target tissues.
Melatonin: increased secretion during darkness; potent antioxidant; regulation of reproductive function by inhibition of steroidogenic activity of gonads (decreases production of gonadal steroids by inhibition of GnRH, which decreases release of FSH & LH)
List, identify, & describe the cell types of pineal gland.
- pinealocytes: arranged in clumps/cords within lobules formed by CT speta; large, deeply infolded nucleus with one or more nucleoli and lipid droplets; secretion of melatonin
- interstitial (glial) cells: reminscent of pituicytes of posterior pituitary gland; astrocyte like
- corpora arenacea/brain sand: calcified concretions from precipitations of calcium phosphates and carbonates on carrier proteins
Describe the clinical signficance of corpora arenacea.
- calcified concentrations are recognizable from childhood and increase in number with age
- used as a convenient marker in radiographic (x-rays) and computed tomography (CT) studies.
Compare and contrast diabetes mellitus and insipidus
Diabetes Insipidus: absence or reduced production of ADH; two types:
- hypothalamic DI (central): no secretion of ADH
- nephrogenic DI: deficient receptor for ADH
Diabetes Mellitus: impaired ability to produce or respond to insulin
Type I: insulin-dependent; anti-pancreas Ab; inability to produce insulin; childhood onset
Type II: insulin-resistance; adult onset
Discuss pituitary adenoma and possible clinical presentation.
- benign tumor; 3 types:
1. Prolactinoma:
- infertility
- amenorrhea (absence of menstrual cycle),
- oligomenorrhea (infrequent menstrual cycle),
- galactorrhea (excessive/inappropriate production of milk),
- decreased libido
2. Acromegaly (GH secreting adenoma):
- sleep apnea
- soft tissue enlargement
- gigantism (youth), acromegaly (adult)
3. Cushing's disease (ACTH secreting adenoma):
- moon face
- buffalo hump
- thick skin
- skin striae
- decreased fertility
- weight gain
- hypertension
- hirsutism
Discuss Conn's disease and possible clinical presentation.
Adrenal adenoma (aldosterone secreting adenoma)
- hypertension
- high serum aldosterone
- low renin levels
Compare and contrast Cushing's diease and Cushing's Syndrome.
Cushing's Syndrome:
- endocrine disorder due to hypercortisolism
- causes: external medication, cushing's disease, adrenal tumor, small cell carcinoma of lung
Cushing's diease:
- pituitary adenoma that is ACTH-releasing
Describe the changes to adrenal cortex in Addison's disease.
- hyposecretion of ACTH leading to decreased glucocorticoids and mineralocorticoids
- eventual shrinkage of adrenal glands
Describe the changes seen in adrenal medulla in pheochromoctyoma.
- tumor of chromaffin cells: chromaffinoma
- abnormal hypertension
- increased production of epi/norepi
- appears more eosinophilic and enlarged cytoplasm


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Purchasing Department - Construction Services / Prequalification
About the Prequalification Committee:
The Board of County Commissioners (Board) established a process which requires major construction and renovation purchases in the amount of $100,000 or greater be provided by firms having met specific financial and experience criteria.
To accomplish this process the Board empowered a Prequalification Committee(Committee), not employed by Pinellas County. The Committee's role is to recommend to the County Administrator the category and dollar limit for which applicants may provide their services; the County Administrator has final approval. The Committee consists of seven (7) members representing the following professional organizations:
The Directors of Purchasing and Public Works are ex-officio members.
The Prequalification process generally takes sixty (60) days or more. The Committee meets four times per year and their recommendations must be approved by the County Administrator prior to contractors being notified of placement on the prequalified listing; allowing participation in bidding on Pinellas County projects.
The approval relates to the type of construction, as well as the value of the project. A combination of evaluation criteria (experience, capability, worth, etc.) is used in determining prequalification.
Construction projects with a total value less than $100,000 normally do not require prequalification. The County does require a contractor to have a valid Florida Construction License and these projects are competitively bid.
Pinellas County Now Pre-Qualifying Electrical and Mechanical Contractors:
We are pleased to inform you that Pinellas County is now pre-qualifying contractors in the Electrical and Mechanical categories. This process will allow Pre-Qualified Electrical and Mechanical Contractors to bid directly on County projects. Interested Electrical and Mechanical Contractors please refer to Pre-Qualification application above.
The Pre-Qualification Committee meetings are held four times per year as indicated in the "Prequalification Meetings" box above.
All meetings begin at 8:00 A.M. and are held in the 5th Floor Conference Room 516, at 400 S Fort Harrison Ave – Annex Bldg, Clearwater, FL 33756

subset: commoncrawl


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Gathered with family members in a hospital room in January 2006, Melanie Schertz made her dying father a promise: "It's OK," she recalls saying. "I'll take care of Mom."
Today, Schertz credits Salt Lake City for enabling her to keep that promise. Thanks to an ordinance approved by the City Council a month after the sudden and unexpected loss of her father, Schertz was able to share her health insurance benefits with her mother.
The ordinance prevented the family from being financially devastated later that year, Schertz said, when her mother suffered a serious fall, fracturing the upper palate in her mouth, knocking out a tooth and sustaining a concussion.
"If she had no insurance whatsoever, we would have been done," Schertz said. "We would have lost everything."
Schertz will be among the Salt Lake City employees at the Capitol on Monday sharing their personal stories with state legislators about how they've benefited from the city's "adult designee" ordinance.
Schertz and others want to show support for the creation of a citywide domestic-partnership registry, an action unanimously approved by the City Council last week. Proposed by Mayor Ralph Becker, the registry provides a mechanism by which other Salt Lake City employers can voluntarily extend heath benefits to their employees' adult designees including gay couples, siblings, long-term roommates and parents.
"In this day and age, the typical family structure is not like it was 20 years ago," said Schertz, a crime-lab technician for the Salt Lake City Police Department. "People have to be together to survive."
Beginning at 8 a.m. Monday, the Senate Health and Human Services Committee will be considering SB267, which seeks to stop or invalidate such registries and the recognition of domestic partnerships other than those created by marriage.
The bill's sponsor, Sen. Chris Buttars, R-West Jordan, has called Salt Lake City's action "wrong," contending that it violates the letter and spirit of both the state's constitutional amendment and state code limiting marriage to a man and a woman.
Schertz says legislators who oppose the city's action are focusing too much on "the gay issue, when it's not just a gay issue."
"They have blinders on," she said.
According to the Salt Lake City mayor's office, 78 percent of city employees who have utilized the adult-designee provision are not same-sex couples. In addition, 10 percent of those employees have named their mothers as their adult designees.
Andrea Curtis, an executive assistant in the city's department of community and economic development, recently enrolled her mother as her adult designee. In the first month of coverage, Curtis' mother saved $200 on prescriptions alone.
"It really makes a big difference to us," she said.
Curtis said she hopes legislators will "look at the bigger picture" to see how many people potentially can benefit from a domestic-partnership registry.
"In this time when everybody is worried about heath care and how to provide health care for seniors and low-income people, we shouldn't be looking for ways to prevent giving insurance to people," she said. "It doesn't make sense to me. Regardless of your position on gay couples, you need to take a better look at who all is affected by this."
According to the mayor's office, the city has legal authority to create a domestic-partnership registry under the general welfare clause of Utah code, which grants the city the power to "preserve the health and promote the prosperity, improve the morals, peace and good order, comfort and convenience of the city and its inhabitants."
The mayor's office also contends that the ordinance does not conflict with the state statute defining marriage.
Such registries have become more common in recent years, with more than 50 percent of Fortune 500 companies providing heath insurance benefits to their domestic partners as of August 2007, according to the Human Rights Campaign, a Washington, D.C.-based advocacy group. In addition, eight of Fortune magazine's 10 largest publicly traded companies offer partner health benefits.
During the 2006 legislative session, former Rep. LaVar Christensen attempted to limit the way in which Salt Lake City offered benefits to adult designees, but the bill died with little fanfare.
The city's adult-designee ordinance passed a legal challenge in May 2006, when 3rd District Judge Stephen Roth ruled that it does not violate sate law or the Utah Constitution. Roth said the ordinance did not appear to create any legal status or rights that are substantially equivalent to a legal marriage between a man and a woman.
Members of the Salt Lake City Council had hoped the domestic-partnership ordinance would not face opposition from the Legislature because it is so similar to the city's adult-designee benefit.
The new ordinance allows qualifying couples who take part in the voluntary program to receive a certificate from City Hall attesting to their domestic-partner status. In order to qualify, individuals must be in a relationship of mutual support, caring and commitment, and be responsible for each other's welfare. In addition, registrants must be each other's sole domestic partner, over 18 years old, competent to contract and share a primary residence in Salt Lake City.City officials plan to have the proper forms ready for Salt Lake City residents to begin registering their domestic partnerships as soon as next week.
E-mail: [email protected]


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Selecting The Best BikeMany people think that choosing a cycling bicycle is simple. Many people think they simply find the bike that looks good and feels comfortable. Wrong, there is more to it these days than simply looks and comfort. Cycling is increasing in popularity in many areas of life, such as sports, hobbies, transport etc. we now have many different bikes to choose from. It is popular in modern times to use a bike as a serious mode of transport. Lots of families have taken up cycling as a family hobby. No matter why you are picking your bicycle, here are some ways to help you along.
The basic key to choosing a bicycle is to buy a bicycle that you can sit on and rest your feet flat on the floor so that you can stop yourself. There are experts who state that this isn't a good way to choose a bike, however. These people explain that the best way to pick a bike is to ensure there is a few inches between the ground and your feet, and you will be provided with a much more comfortable ride. If your feet are sitting flat on the ground while your butt is on the seat, this usually means that the seat is too close to the crossbar and will need to be adjusted for comfort. This is because when you are pedaling with this bike, your knees are a knockout post going to come up too high.
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Check out which companies are making headlines before the bell Friday:
Apple - The technology titan advanced in premarket trading after releasing an update to software that had glitches for its latest iPhones.
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Finish Line - The seller of athletic wear dropped after reporting disappointing quarterly results.


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Published in the Seattle Times Dec. 3, 2017
This fall the U.S. Census Bureau brought good news when it informed us that the nation's poverty rate had fallen from 13.2 to 12.7 percent.
But now more than ever, we should be suspicious of this news.
Published in the Seattle Times Dec. 3, 2017
This fall the U.S. Census Bureau brought good news when it informed us that the nation's poverty rate had fallen from 13.2 to 12.7 percent.
But now more than ever, we should be suspicious of this news.
Published September 27, 2017 in The Hill
Linda Gorman, director of the Independence Institute's Health Care Policy Center, recently argued on these pages for a repeal of ObamaCare. Gorman claims that the movement toward a more European-style health care system, such as Obamacare steers us toward, leads us in the wrong direction. For support, she compares our health care system with Switzerland's.
I'll address that comparison toward the end of this article. Before getting there, though, I want to engage Gorman's broader argument, both because it draws for support on my research comparing health care financing in the US with other countries, and because it misses basic health care economics.
To tackle the essence of Gorman's argument that Americans are better off with a health care system leaving some uninsured, let's step back from the specifics of Switzerland's health care system. Let's instead examine the "European (or Asian)" model of health care. Continue reading
Published in The News Tribune, June 19, 2013
Back when he was president, Ronald Reagan famously (or infamously) reduced complex concepts to simple ones he thought the public could understand.
To explain the size of our nation's debt, which in 1981 had just topped $1 trillion, he summoned the image of one trillion dollar bills stacked one on top of the other. My mind's eye still can see that tower of bills reaching up beyond the stratosphere, extending one-quarter of the way to the moon. Continue reading
Published in The News Tribune, February 27, 2013.
Each year as a nation, we spend more than $150 billion on research to find health-improving products. Such research has led to spectacular advancements in the health of those born prematurely or afflicted with heart disease, diabetes or cancer.
Yet when it comes to promoting a healthy population, we shouldn't be so quick to congratulate ourselves. Continue reading
Published in The News Tribune, December 19, 2012
The news from Newtown, Connecticut has many of us revisiting recent horrors where unstable citizens in our own communities committed the unspeakable crime of killing off-duty police officers, a sleeping father, a park ranger, and far too many others. Yet even these senseless crimes pale in comparison with the terrifying violence visited last week on children at Sandy Hook Elementary School.
New York Times columnist Nicholas Kristof passionately, predictably — and correctly – has called for stricter control and regulation of our nation's guns. Continue reading
Published in The News Tribune, November 22, 2012
Often, holiday meals like those at my house consist of a range of separate contributions which collectively add up to the Thanksgiving Dinner. As we sit down to partake of the varied assortment of dishes, no one would think of criticizing the turkey because the mushroom soup dish contained more fried onion rings than green beans, or because someone insisted on adding a bag of marshmellows to the sweet potatoes.
The fact that different dishes are on the same table doesn't somehow turn them into one "Dish" called "Thanksgiving Dinner" that deserves a singular judgment. Instead, we pass judgment on the successful (and quietly perhaps, the less successful) features of each individual dish. Continue reading
Published in The News Tribune, August 2, 2012
The Supreme Court's decision this summer to uphold the most controversial part of the Affordable Care Act (ACA) – the "mandate" requiring individuals to buy health insurance – was both historic and a critical victory for those battling to achieve universal health care in the United States.
However, while most of the public's attention has rightly focused on the Court's determination that the federal government can indeed require us to buy health insurance, this wasn't the only provision in the ACA that opponents argued was unconstitutional: They also claimed that the ACA's expansion of Medicaid to more of the nation's poor coerced states' participation by setting the penalty for nonparticipation too high. Continue reading
Published in The News Tribune, December 21, 2011
Today's column concerns "deadweight loss."
Why anyone would coin a term "deadweight loss" (DWL) is beyond me. But someone did and we're stuck with it. Of all economic expressions this is the worst, conjuring up images of the Mafia and concrete boots. But DWL is important; in order to have a "healthy" economy we should eliminate it. Read on to see where I'm going. Continue reading
Published in The News Tribune, October 25, 2011
With little fanfare, a Class Act died earlier this month.
Formally known as Community Living Assistance Services and Supports, Class Act was a short-lived health care program created as part of the recent health care overhaul. The Obama Administration has just now cancelled it.
Class Act's demise is noteworthy — certainly much more than would be indicated by its placement on the back pages of the newspapers. Its end helps remind us of a present and growing problem we have yet to solve. It also reminds us of the inadequacies in current health care policy. Continue reading
Published in The News Tribune November 14, 2010
Bolstered by the election, Republicans are now renewing their commitment to repeal Obama's health care reform act. The government's "takeover of health care" was a bad idea, they say. Courts in the meantime are reviewing the Act's constitutionality, with many arguing that the federal government cannot legally mandate insurance.
Not being a constitutional scholar, I'll take a pass on this legal challenge and instead say why mandating insurance is exactly what the federal government should be doing.
Aside from a moral argument that everyone should have health insurance, the reason for mandating insurance is that without universal coverage, the health insurance market is unacceptably wasteful and unfair. Continue reading


text:
By MARC KOVAC
Dix Communications
COLUMBUS -- The Ohio Development Financing Advisory Council signed off Monday on $10 million in financing for a major expansion at Smith Dairy in Orrville.
The company is eyeing a $20 million project to increase its manufacturing capacity after landing a contract with the popular burrito chain Chipotle to provide sour cream to all of its restaurants east of the Rocky Mountains.
"This is a major, major undertaking for this company," Tracy Allen, a Department of Development employee who worked with the company on the project, told members of the council Monday.
The council OK'd a $2 million low-interest 166 Direct Loan and $8 million in financing from the Ohio Enterprise Bond Fund for the expansion, both of which must be approved by the state Controlling Board before they are finalized.
The funding will be used to purchase new cottage cheese and sour cream production lines and a high-speed fluid milk production line, according to documents. The equipment will be housed in a new facility a mile north of the city, at the site of the company's office and distribution building on Dairy Lane.
Smith's will retain 369 jobs with the project, according to documents.
Company president Steve Schmid told council members Monday the expansion would allow the company to double its sour cream from production, from the 9 million pounds it currently makes.
Smith's buys milk from about 200 farms within a 50-mile radius of its Orrville plant, Allen said. Most of those farms have smaller herds with access to pasture, which helped land the Chipotle contract.
"A lot of these cows have access to free range," Allen said. "You have these smaller dairies, they're not these mega farms."
n Marc Kovac is the Dix capital bureau chief. E-mail him at email@example.com or on Twitter at OhioCapitalBlog.


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Once you are rein the North, you should definitely take the chance and make a detour to Mompóx on your way southwards. This UNESCO World Heritage town is not located on the typical tourist routes, though, but with its island position and the pretty colonial houses it is absolutely worth seeing. Time stands tonlos here. The only thing you can hear is the squeaking of the ventilator (and the engine noise of the numerous mopeds on the streets). There are no big sights next to the churches, but the town itself is a sight worth seeing – with its houses, its location, its people.
Not only the architectural highlights succeed hinein convincing the UNESCO. Colombia's most famous export Klopper possibly put its specialcharms. Thus, Colombia's "cultivated coffe landscape" is a UNESCO World Heritage since 2011. As a professed coffee lover, who travels to coffee-destinations like Ethiopia or Panama with increased regularity, I just had to include a visit to the coffee triangle rein my route. From Armenia we went to the small, but touristically popular Salento. A coffee Spritzfahrt welches mandatory of course. We chose the more unconventional variant the Lanthan Serrana offers. We receive vague directions and meet Pedro Burgos at a crossing, who runs the small coffee farm "Reserva Café Sachamama" together with his wife Maryori rein the Quindio river valley.
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After many years of disregard because of the political situation, Colombia as a travel destination for individual travellers seems to Beryllium back on many people's agenda, especially in German-speaking countries.
The gold museum in the Candelaria ranks among the city's must-have-seen-things. Within a three-hour Spritzfahrt with audio guide, you get to know everything about the metal deposits, especially gold, sorted by region, time and usage. It probably makes more sense to visit the museum at the end of a trip, as you can pin down the seen with your previous knowledge. Frankly, you get way too many information after a while. For me it welches after 1,5 hours. I liked the regional classification very much, but that's the part where the information becomes repetitive, as most of the peoples used their gold for similar things or made similar items out of it. Another museum every art lover should go to is the Botero museum, where you can admire works of Botero and other artists.
It takes four hours by bus to get to the pearl of the Caribbean located to the west of Santa Marta: Cartagena. It certainly ranks among the most beautiful colonial cities of South America and this is one of the main reasons why Cartagena has the most visitors. Within the completely walled town centre of the UNESCO World Heritage city, Colombian and international tourists are bustling. This is where the lovely restored houses, the cathedral and the numerous Andalusian-style palaces are located.
We perceived the safety situation rein the country generally as good and were always welcomed openly and interestedly by the police and the military.
Im Macondo Hostel wirkte alles sehr relaxt ansonsten teilweise sogar verschlafen auf mich, obwohl es ausgebucht war. Weniger Partypeople sondern etliche outdoor begeisterte Gäste, die hinter ihren Erlebnissen (z.
My first trip only led me northbound to Santa Marta via the beautiful colonial town Villa de Leyva with its one-storeyed tiled roof houses and the centuries-old cobblestone as well as the adventure and outdoor-El Dorado San Gil. I liked Santa Marta immediately. At least hinein 2009, the seaside town wasn't polished up like the twin town Cartagena yet, but you could Teich that something was hinein motion already. When I went back rein 2013, I actually discovered a well restored, tourist friendly town centre, where restaurants, cafés and accommodations full of charm string together. Santa Marta is a big city full of Caribbean life and with a wonderfully impressive scenery – the Caribbean hinein Vorderseite of me, the Sierra Nevada behind me, which is the highest coastal area of the world with its peaks Pico Cristóbal Colóstickstoffgas and Pico Simóstickstoff Bolívar, both 45 kilometres away and 5.
2r. You can admire numerous archaeological parks either by foot or on horseback. The route through the scenically appealing, befogged environment to Popayan welches difficult in the past, but is easier now because of street works. The white city impresses with its colonial architecture, too.
I like going for a drink on the Plazoleta del Chorro de Ouevedo near the university. This is where bigger tourist groups Potpourri with the students by now. It's bar next to Schank and you can also listen to a speech by one of the students hinein Vorderseite of the church. The Reste is music and entertainment. Numerous churches and convents adorn the city and the Plaza Bolívar forms the centre. This monumental place is dominated by three big building complexes: by the classicistic cathedral, finished in 1823, by the office of the congress "Capitolio Nacional" with an enormous columned hall and by the office of the mayor "Alcaldía de Bogotá". The mighty palace of justice is located on the northern side of the place and is evocative of the dramatic incidents in 1985, when the Guerilleros took hostages, whereupon the palace got shot to pieces.
Samuel Muñoz sagt 25. September 2016 Hola muy interesante su blog: para aquellos viajantes por Colombia quiero ofrecerles mis servicios de alojamiento en Popayan Cauca, al Sur Occidente delo Pais donde existen restos de culturas precolombinas muy interesantes para visitar….un sitio con excelente relacion calidad-precio. Un saludo desde
However, we escaped into nature again and would have regretted it if we wouldn't have taken that time. The surroundings of Medellin are idyllic and beat everything, as we finally catch a glimpse of the huge flooded parte of the countryside. This region surrounding Guatapé reminds me of Lake Bunyoni rein Uganda. A thousand small hills emerge from that enormous seascape. We are fascinated immediately. It's hard to believe that this is a flooded landscape, a huge water reservoir. It is and will remain the most beautiful one I have ever seen.
Speaking of flora and Tierwelt: The German scientist Alexander von Humboldt welches already impressed by Colombia's abundance of species and variety of plants. I welches just as fascinated as Humboldt at the beginning. And where is the best place to experience the abundant variety? Rein the jungle near the Amazon! All my trips Leuchtdiode me there. I headed for the town Leticia in the jungle and near the border three times, which was the starting point for many tours through the primeval forest. Once, we went up the river Rio Yavari to Camp Palmari (on the Brazilian side). Hiking tours in the jungle, kayaking through bizarrely flooded areas, bathing, bird watching… The days passed by so quickly. We drove up the Amazon another time and Satz up our "camp" hinein the car- and moped-free little town Puerto Nariño. We hiked into the primeval forest from there as well, visited indigenous villages, swam with pink and grey dolphins and enjoyed the noisy return of the parrots from the surrounding forests every evening.
775 metres high. You can establish your base camp for the exploration of Colombia's North-eastern region rein the city, which welches founded in 1525: hiking tours starting in the nearby Minca to the fog forests of the Sierra Nevada, days at the beach in the Tayrona Nationalpark with its vast and natural Caribbean beaches that reach from the laid-back place Palomino to Riohacha and further, diving in Taganga, which is only 30 minutes away, or a multi-day trek to one of the biggest, rediscovered pre-Colombian site of South America – Ciudad Perdida (Buritaca 2000 or Teyuna). On your way there you encounter the protected Kogis who live here and descend from the Taironas.
During the day, you can hear a groaning coming from the cooled rooms: "hace mucho, mucho, mucho caliente". And just like that, the traveller life is slowing down a little bit as well. Mompóx ranks among click Colombia's hottest cities and you believe that immediately. However, if you do leave the Astrein houses after all, then only to discover the beautiful Cienega de Pijiñov with its verstile Tierwelt, located near the Rio Magdalena, Colombia's longest river.
Weltgesundheitsorganisation is tired of nature can find a relatively gewöhnlich big city life rein Bogotá, Medellin or Calí. There are numerous cultural activities and parties. It's the legendary salsa parties rein Calí that Leuchtdiode us to the Tin Tin Deo for example. We didn't learn the typical Salsa Calena rein that short amount of time, though, but the simple Salsa Cubana welches enough for the rhythms. It's just that you attract attention that way. Hinein Medellin, it's the numerous museums and hinein the evening probablyalso the bars hinein the neighbourhood of Poblado that attract the visitors.
schwimmen mit delphinen türkei side - Eine Übersicht
Also je 3 Wochen mit einem Budget von nur 1000 €, Dasjenige finde ich doch sehr knapp festsetzen....Ob man pro Dasjenige kleine Geld ein wirlich gutes Hotel bekommt bezweifle ich.


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Support Ingrid and Eliseo today! Please sign the Petition Now.
On Thursday of this week, Immigration and Customs Enforcement (ICE) detained Eliseo Jurado without warning. Eliseo is the husband of Ingrid Encalada Latorre, a leader in Colorado's sanctuary movement who is currently in sanctuary at the Unitarian Universalist Church in Boulder, CO.
Ingrid is a leader with the Metro Denver Sanctuary Coalition and is part of national movement for immigrant rights. She claimed Sanctuary at UUCB last month. "ICE's detention of Eliseo feels like a direct attack on our family," said Ingrid Encalada Latorre. "His work sustains our family. He has the right to fight his case and, although I am sad and angry, we will fight. I invite the support of the whole community in what lies ahead for us."
Eliseo Jurado arrived in the U.S. as a teenager, when he left Mexico to rejoin his family. His father is a U.S. citizen and his mother a permanent resident. Because U.S. laws have created a decades-long backlog for Mexicans attempting to reunite with families in the U.S., he came to be with his parents. Eliseo has lived in Colorado for many years, where he met Ingrid. Eliseo is step-father to Bryant, 9 and father to two-year-old Anibal. Six ICE agents detained Eliseo yesterday in the parking lot of a Safeway, even though nothing about his life or his immigration status had changed in any way.
"The completely unjust detention of Eliseo is an attack on both Eliseo's human rights and the growing sanctuary movement in Colorado and across the nation,"said Rev. Dr. Jack Sullivan, Co-President of Disciples Justice Action Network (DJAN). "We will continue to work with other people of faith and conscience to keep families together and keep our communities whole."
"It is morally repugnant that Immigration and Customs Enforcement (ICE) would engage in what appears to be retaliation," said Ann Marie Coleman, Co-President of DJAN. "We stand with Ingrid and Eliseo in their struggle against injustice, and call for Eliseo's immediate release."
January 13, 2018
DJAN Calls for Immediate Release of Eliseo Jurado: ICE Detains Husband of Colorado Sanctuary Leader
Posted by Bridget at Saturday, January 13, 2018
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I know better than to fall for this act. I've seen it far too many times in the past. But, there I was on Tuesday afternoon/early evening watching Will Venable take the first pitch he saw in Petco Park in 2013 deep to right for a solo HR. Later, he provided the proverbial nail in the Dodgers coffin when he hit a bases clearing triple in the 8th inning.
And there I was. Falling all sorts of in love with the potential of Will Venable. Again.
I just can't quit you Will.
Will Venable toys and teases Padres fans unlike nearly any player that I can remember. In part its because Will Venable is extremely likable. In 2008 he moved closer to the Padres training facility to help aid his workouts and progress. During Spring Training in 2012 he took on Yu Darvish who, after Venable took him deep said through that Venable didn't square up on the ball and the HR was "wind aided." Venable's response? "Of course I didn't hit is squarely…because he's Yu Darvish. And I'm Will Venable."
Maybe it's the Ivy credentials that make him so likable. Like former Padre Chris Young, Will Venable was a Princeton Tiger though he went for basketball (competing in the 2004 NCAA Tournament) not baseball. He took up baseball at Princeton in his sophomore year, allegedly due to his mother's urging. This made him only the second athlete in Ivy League history to play both sports (Chris Young was the other).
He became a regular MLB member in 2009 but made his San Diego debut in 2008 thanks to an injury to Scott Hairston. He tripled in his first at-bat because, of course he did. That winter he spent at the Padres Dominican facility playing Winter Ball where he struggled mightily, racking up more strikeouts than hits (18-15). His comments about his experience in the Domincan? "I wished I was exposed to that before I wrote my senior thesis. I would've gotten an A. I found an infinite amount of materials to write about. And the love I had for the game."
You can take almost any random sampling of 8-10 games in Will Venable's career and see either the potential star that he could be or the player that suddenly and without warning falls off the edge.
The first 8 games of the 2010 season: 9/34, 8 RBI, 2 HR. Not bad. That same season he hits a HR on April 24. He doesn't hit another one until June 23. He had an OPS of .817 in June of that year. July? .440. In 2011 he takes until May before he has a 3 hit game (he has only two multi-hit games in the month of April). But he tears up June and August of that year (OPS of .834 and .784 respectively).
Such is life with Will Venable. He has been chosen as the Padres breakout player for what feels like my entire life. He has been considered the most likely player to hit for the Padres first cycle (a feat he accomplished on May 20, 2007 with the San Antonio Missions).
He has all the tools to be a great player. And yet…he isn't. He is at times of course. But then he gets into a slump. And all the Ivy education in the world can't get him out of it. When he got into a prolonged slump during the Dominican Winter league, he said this about it: "Down there, it doesn't take long for guys to expose you, and I immediately fell into a big slump I couldn't get out of. And it was no one's fault but my own."
In some ways, nothing has changed. Because for all his talent and potential, when he slumps he slumps badly. And for an extended period of time.
I know all of this. I know that the Venable of Tuesday afternoon will slump and that what we saw is likely a mirage. But I also know that the potential for Tuesday to be the norm and not the exception is in him. And despite knowing better, here I am, yet again falling for the siren song that is Will Venable.
(Postscript: The following two days Venable went 1 for 8 with 1 RBI.)


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Detached bungalow for sale in Lawn Road, Staplegrove, Taunton TA2
* Calls to this number will be recorded for quality, compliance and training purposes.
Property features
- A spacious three bedroom detached chalet style bungalow
- Located in the sought after village of Staplegrove
- Good sized garden with an above ground heated swimming pool
- Living room with a log burner with Minster Stone surround and hearth
- Kitchen and conservatory
- Third bedroom/sitting room
- Office/games room and a second conservatory
- Ground floor bathroom * two first floor bedrooms
- Drive parking and garage
- No onward chain
Property description
The property:
Standing in the favoured village of Staplegrove on a generous garden plot, this detached chalet style bungalow offers good sized adaptable family accommodation with ample drive parking and an above ground heated swimming pool with its own solar panels.
The property is provided with gas fired central heating and sealed unit double glazing and briefly comprises an entrance porch to hall, cloakroom/wc, living room, kitchen/breakfast room, conservatory, ground floor bedroom/sitting room, bathroom and two first floor bedrooms. Adjoining the property and ideal for the purchaser working from home is a very useful office/games room with a second conservatory and a single garage. Outside there is ample drive parking lawned gardens with shrub bed borders enveloping the property and a summerhouse.
total floor area:
96 sq.M.
Property info
Floorplan View original
3D Floorplan View original
Nearby transport
- Taunton (1.2 miles)
- Bridgwater (8.7 miles)
- Tiverton Parkway (13.1 miles)
- Exeter International Airport (24.3 miles)
- Cardiff Airport (26.8 miles)
- Bristol Airport (29.8 miles)
- Bridgwater Ferry Terminal (9.4 miles)
- Minehead Harbour (19.6 miles)
- Weston-super-Mare Knightstone Harbour (22.7 miles)
Nearby schoolsView all schools in Taunton Deane
- Staplegrove Church School (0.5 miles)
- Wellsprings Primary School (0.8 miles)
- St Andrew's Church School (1.0 mile)
- Taunton School (0.6 miles)
- King's College (2.0 miles)
- Wadham School (17.8 miles)
- Taunton Preparatory School (0.6 miles)
- Park House, Taunton (SEN) (0.9 miles)
- The Taunton Academy (1.0 mile)
Local info for Taunton Deane
About the neighbours in TA2
For more information about this property, please contact
Ware & Co, TA1 on +44 1823 429175 * (local rate)
Property descriptions and related information displayed on this page, with the exclusion of Running Costs data, are marketing materials provided by Ware & Co, and do not constitute property particulars. Please contact Ware & Co for full details and further information. The Running Costs data displayed on this page are provided by PrimeLocation to give an indication of potential running costs based on various data sources. PrimeLocation does not warrant or accept any responsibility for the accuracy or completeness of the property descriptions, related information or Running Costs data provided here.


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Flashcards in Chapter 3 - Customer Expectations of Service Deck (24):
Are needs those things that we need for survival?
No, they are things that we need such as self actualization etc. So a very extroverted person who socializes a lot and travelling alone is going to want a hotel with a really great bar. Because that is where they will satisfy their social need
What are 5 frequently asked questions about customer expectations?
1. What does a service marketer do if the customer's expectations are unrealistic?
2. Should a company try to delight their customers
3. How does a company exceed customer service expectations
4. Do customer service expectations continually escalate?
5. How does a service company stay ahead of competition in meeting customer expectations
Should companies try to delight their customers?
Well this could result in a spiralling rising expectations. A good strategy is a sustainable competitive advantage
When does the greatest gap between customer expectations and service delivery exist?
When customers travel from one country to another. Like japan being customer service superstars, and Canada being just ok
What are customer expectations?
Beliefs about service delivery that serve as standards or reference points against which performance is judged
What is the first and possibly most critical step to delivering quality service?
Knowing what the customer expects (the customer expectations)
What are the 5 levels of possible customer expectations from low to high?
1. minimum tolerable expectations (shitty service, good price)
2. Acceptable expectations (Its ok)
3. Experience Based norms (good, but slow when busy)
4. Normative "should" expectations (real expensive, better be really good)
5. Ideal expectations of desires (this is the best restaurant in town, I'm expecting something incredible)
What are the dual customer expectation levels?
Desired Service (I want my uni to find me a job)
Adequate service (They'll try, but I understand if they can't)
What is the zone of tolerance?
This is the space in-between the desired service level and adequate service level.
What if your above zone of tolerance for customer?
They will be very pleased and probably surprised as well
What if your below zone of tolerance for customer?
They will be frustrated and most likely dissatisfied with company
How can a customers zone of tolerance change?
It can contract and expand. An example is a woman running late for her plane, so the time zone of tolerance for the barista making her drink is a lot less.
The fluctuation in a customers zone of tolerance is more a change in _______ service level, than _____ service level
The fluctuation in a customers zone of tolerance is more a change in ADEQUATE service level, than DESIRED service level
because the adequate service level is a lot more dependant on situational circumstances (such as running late for something)
What are the three major influences on the "desired service" level?
1. Personal needs
(so hungry man straight from work is gonna want a hotdog at bball game than recently fed man)
2. Personal service philosophy
(So someone who believes how service should be delivered, water to table etc. Strong with service industry veterans such as myself)
3. Derived service expectations
(So this is when you also have the weight of other people to consider, such as your customers. If I use a SM tool, I would consider the clients I'm catering to with its capabilities)
What are three factors that influence adequate service levels?
1. perceived service alternatives
2. Situational factors
3. predicted service
How do perceived service alternatives affect your adequate service levels?
So the lack of alternatives reduces the fluctuations. Such as a girl living in a small town with one tiny airport. She's not going to be complaining of limited flight options as much as if a big city girl would if she couldn't find a flight to Miami in a New York minute.
How do the two types of situational factors affect your adequate service levels?
uncontrollable situational factors: These usually temporarily lower the adequate level of services and widen the zone of tolerance. So hurricane katrina made New Orlean guests at the Ritz a lot more forgiving during the catostrophe to lower service
Personal Situational Factors: These raise the adequate level of services, and narrow zone of tolerance. So if your window gets broken on your BMW, your gonna want that shit fixed and be anxious for them to give you quick service
How does predicted service affect your adequate service levels?
This is the level of service customers think they are going to get
What are the 4 factors that influence predicted service, as well as desired service to a degree?
1. Explicit service promises
2. Implicit service promises
3. Word of mouth communication
4. Past Experience
What does a service marketer do if customer expectations are unrealistic?
They should actually ask the customers themselves, and then act on their feedback or inform them of why it is the way it is. They can also communicate ways they are improving based on feedback
Should a company try to delight the customer?
So you have musts, satisfied, and delights levels of a service. Be careful when you delight, although it may lead to repeat customers, it costs a lot, and the benefits must outweigh the costs. If they choose to delight, do so in areas that cannot be copied by other firms
How does a company exceed customer service expectations?
So you can be like Ritz and collect information about the customer to really delight them with things like favourite flowers on the nightstand.
Or you can deliberately under promise and then over perform the service.
Or you can position a service as a temporary unusual stint. So serving beverages on a super short flight where its not expected and saying this is just for the one time.
Do customers service expectation continually escalate?
Yes, adequate service levels can rise real quick! Desired service expectations doesn't really fluctuate as much though