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A few weeks ago, a group of staff members had the opportunity to visit some of our local vendors. A group of us packed into a 15 passenger van and headed down Route 7 to visit our friends to the South.
Throughout the year, City Market staff members make the rounds to visit our local producers and get a behind the scenes look at their operations. With over 2,700 Local and Made in Vermont products, we have plenty of incredible vendors to choose from. This past week, a group of us visited Miskell's Premium Organics in Charlotte and Besteyfield Farms at their new space in Hinesburg.


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December 11, 2014
Plein Air Magazine Editor M. Stephen Doherty using the STRADA Easel
Only 2 Days left to Win a FREE STRADA Easel for Christmas! This was a BIG month for STRADA sitings in the December issue of Plein Air Magazine. See if you can find them all and email us with the details. Those with the correct response will be entered to win a Strada Easel!!! Offer expires Dec. 12th and the winner will be announced on December 13th. Email us at email@example.com to be entered to win. #pleinair #stradaeasel #pleinairmagazine #freestradaeasel — at Plein Air Magazine.
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Low expression of fibulin-1 correlates with unfavorable prognosis in gastric cancer
- 152 Downloads
- Citations
The tumor-suppressing role of fibulin-1 has been described in several types of cancers. However, the expression and role of fibulin-1 in the development and progression of gastric cancer (GC) remain largely unknown. In this study, RT-PCR and immunochemistry were used to detect the fibulin-1 expression in GC samples. We have found that the fibulin-1 protein and mRNA levels were downregulated in GC. When investigating the correlation between fibulin-1 expression and clinicopathological characteristics, we have found that low fibulin-1 protein expression was associated with poor tumor differentiation and advanced N stage. Low fibulin-1 protein expression was also an independent prognostic factor for patient survival. To clarify the reason of fibulin-1 downregulation in GC, the mRNA expression and methylation status of fibulin-1 were examined in GC fresh tissue samples (n = 36). We found that the transcriptional expression of fibulin-1 was negatively associated with fibulin-1 promoter hypermethylation, and fibulin-1 hypermethylation was associated with Helicobacter pylori infection. Finally, the effects of fibulin-1 overexpression on cell proliferation and apoptosis were examined. We have found that fibulin-1 overexpression suppressed the growth of GC both in vitro and in vivo and induced apoptosis by increasing cleaved caspase-3 expression. In conclusion, fibulin-1 acts as a tumor suppressor gene, is frequently hypermethylated in GC, and can potentially serve as a useful biomarker for patient prognosis.
KeywordsFibulin-1 Gastric carcinogenesis Epigenetic Tumor suppressor gene Prognosis
This work was supported by the National Natural Science Foundation of China (no. 81000984), the Six Talent Peaks Project of the Jiangsu Province (2011-WS066), and the Social Undertakings of Science and Technology Innovation and Demonstration Project of Nantong City (HS2014042).
Compliance with ethical standards
Conflicts of interest
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All EGR1 reagents are produced in house and quality controlled, including 2 EGR1 Antibody, 21 EGR1 Gene, 1 EGR1 qPCR. All EGR1 reagents are ready to use.
EGR1 antibodies are validated with different applications, which are ICC/IF, IF, WB.
EGR1 cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each EGR1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.


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Posted by pinksharkmark (188.8.131.52) on June 16, 2001 at 08:14:11:
In Reply to: Imitrex, how old is too old? posted by Van on June 15, 2001 at 21:03:13:
Medications are dated conservatively. If a date says May 2000, it should really read May 2001.
The date at which a compound loses an arbitrary percentage of its strength is considered to be the expiration date. I have no idea exactly what that percentage might be. A licensed pharmacist should be able to tell you.
Almost all complex molecules will break down over time under the influence of heat, light, oxidation and humidity. Once a medication passes its expiration date, it doesn't automatically become poisonous, it simply becomes less and less effective, since more and more of the active ingredient has broken down to simpler compounds.
If your Imitrex injectors were stored according to the directions that accompanied them, they should still be 99% as effective as the day they were purchased.
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The magic of Ceramic of Manises
Departure to the Ceramic Museum of Manises which aims is to preserve the knowledge of the traditional Valencian ceramic culture, as well as the culture and history of Manises (the largest ceramic production centre in Spain since the 14th century). It is located in the old Obradors neighborhood of Manises dating back to the 14th century.
Guided visit in a new trend Ceramic Factory.
This is ceramics, innovation and design. Explore another kind of craft production and design of ceramic. His owner, the craftsman and ceramic researcher Juan Carlos Iñesta, tries to experience to the limit with this ancient product which allows to a wide world of work and artistic possibilities. He looks to the future looking for new ways and trends of ceramic. He has worked with some of the best designers like the Valencian architect Santiago Calatrava or with some Michelin Star chefs like Quique Dacosta designing the silverware for his restaurants. He has been rewarded between others by the Spanish Association of Ceramic Cities for his design and technique work.
Enjoy a different ceramic workshop. Any of us could make a masterpiece and the best and the most especial work of art. Just open your mind, be creative, experiment, feel and enjoy yourself in a very especial and original workshop which will allow you to bring back home your own artistic creation.
- Price: €149 per person (including taxes)
- Activities available in the following languages: Spanish.English.French.German.Italian.Portuguese
- Place:
Manises (Valencia)
Valencia (Valencia)
- Duration: 4 Hours
- Date available from: 27/04/2018
- Date available to: 31/12/2019
- Additional information: Booking subject to availability
- Category of the activity: Culture and traditions
- Who is it for?: LGBT. Senior. Adults without children. Families. Young people
- Organising company: ART VALENCIA
Information från leverantörenSkriv ut
Ceramic of Manises
Ceramic of Manises
Ceramic of Manises
Ceramic of Manises
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Diehard technology fans queued for up to 12 hours to get their hands on the latest mobile phone on the market.
Fanatics desperate for Apple's new iPhone 6 and iPhone 6 Plus queued for hours outside Eldon Square shopping centre in Newcastle in the rain.
In the early hours of the morning, over 300 fans stood in the queue that snaked up Newgate Street before the Apple shop was finally opened at 8am.
Fans were still waiting outside at 10am on the day of the launch of the handsets which promise 4G reception and longer battery life.
But many were left disappointed after the shop sold out of the iPhone 6 Plus - the bigger version of the new phone.
Osan Al-Jaberly, 18, a student from Gosforth, said he waited in line at the Metro Centre at 4am, but left after he was told only the iPhone 6 was being sold.
He then made his way to Eldon Square only to find out his desired 6 Plus was already sold out.
He said: "It wasn't worth me waking up so early - they won't get more iPhone 6 Pluses in until next week.
"I'm going to go home and complain to Apple - they need to sort their self out and get more stock in the future."
The lucky first fans to get their hands on the new models waited 12 hours for their phones.
Calvin Liu, a 20-year-old student who lives in Sunderland, said: "I came here at 9pm last night and there were about 15 people in front of me. I've had all the models of the iPhone: the 4, the 4S, the 5 and the 5S. I'm a huge iPhone fan."
He walked away with one iPhone 6 and one Plus, bought for his girlfriend.
Others came well prepared for the long wait.
James Bunting, 24, bought chairs, crisps, an umbrella and an energy drink and sat with two friends playing games in the queue from midnight.
He said the team from Apple arrived at around 6am and let only a few people into the mall, while leaving hundreds of others to continue waiting.
He managed to grab a phone just before 10am this morning.
"It was a long nine hours but nine hours well served," he said.
But not everyone was so lucky. A group of fans who arrived at 4am were still waiting at the end of the queue in the shopping centre by 9am on the long-anticipated day of the launch, while many more were still stuck outside. Student Jamal Khan, 18, from Stockton said: "We came here at four in the morning and we're at the back of the line waiting for the phone. It's a bit upsetting."
He added that he had only managed two hours of sleep overnight.


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Great video! Would love to eat that sweet hairy pussy!
Julia bond is a bisexual I think she should learn to control her sexual feelings and keep her private parts to her self
I love that hairy big cock!
Fucking hot, but if you look closely around 16:10 there is some shit juice leaking! LOL!
the most boring porn i've ever seen ... he can't fuck and she seem not into it


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Diego Báez is a writer and educator whose poems, stories, and reviews have appeared in Granta, The Acentos Review, and The Los Angeles Review of Books. He lives in Chicago and teaches at the City Colleges.
Corrie Baldauf is an Assistant Professor of Art at Eastern Michigan University. Her art practice is based out of a shared studio space in Corktown, Detroit. Baldauf's art has appeared in German Art Magazine, Fukt: Magazine for Contemporary Drawing, Hyperallergic, Lufthansa Exclusive Magazine, HOHE Luft Magazine, and most recently in the digital architecture and design magazine, Designboom.
Matt Bucher is the co-host of The Great Concavity podcast and administrator of the wallace-l listserv. His writing has appeared in Electric Literature, Dublin Review of Books, Chicago Review of Books, and other places. He lives in Austin, Texas.
Grace Chipperfield is a PhD candidate in Creative Writing at Flinders University in South Australia. She is researching what it is to be an American citizen and how this relates to adolescence and adulthood in the works of David Foster Wallace. In 2017 she received a Fulbright Postgraduate Scholarship in support of this research. She is also an associate editor for The Journal of David Foster Wallace Studies.
Ryan Edel is a PhD candidate in Creative Writing and Rhetoric at Illinois State University. Although he'd never admit this in polite company, he also writes science fiction. Usually the kind that would require a red beanie, or perhaps a black one. Ryan is the current chair of the annual DFW Conference at ISU, and he serves as conference liaison to the DFW Society.
Dr. Clare Hayes-Brady is a lecturer in American Literature at University College Dublin.
She has published and presented widely on aspects of contemporary American literature, with a particular focus on gender identity and voice, and is the author of The Unspeakable Failures of David Foster Wallace (Bloomsbury Academic, 2016).
Other research interests include family/parenthood in contemporary fiction and film, adolescence in contemporary culture, dystopian narrative, ecocriticism and narratives of journey, performative sexuality (both normative and queer), resistant gender modes and the history of burlesque, transatlantic cultural heritage, and digital humanities and modes of transmission.
Outside of academic work, she likes cats and barbershop singing and has a tiny whirlwind of a daughter named May.
Dave Laird (BA, BEd, MA) is the co-host of The Great Concavity podcast and was a weekly contributing guide for Infinite Winter in 2016. His MA thesis was on the dialogue between Infinite Jest and notions of soteriology in Christian thought. His work has appeared in Normal 2015: Selected Works from the Second Annual David Foster Wallace Conference. Dave teaches high school humanities and lives in Victoria, B.C., Canada.
Matthew Luter is on the English faculty at St. Andrew's Episcopal School in Jackson, Mississippi. He is the author of Understanding Jonathan Lethem (University of South Carolina Press, 2015). His articles on authors including Don DeLillo, Ellen Douglas, Willie Morris, and Bret Easton Ellis have appeared in journals including Critique, The Southern Literary Journal, Genre, and Orbit: Writing Around Pynchon.
Nick Maniatis is the owner of The Howling Fantods, a website dedicated to promoting the works of David Foster Wallace since 1997. He is also an English literature teacher at Campbell High School in Canberra, Australia.
Dr. Tony McMahon is a published novelist and journalist with a PhD from RMIT University. He has presented papers on David Foster Wallace at several conferences including Infinite Wallace in Paris, DFW15, and DFW16. In September of 2017 he chaired Australia's first ever conference devoted to Wallace, OzWallace 2017.
Mike Miley teaches literature at Metairie Park Country Day School and film studies at Loyola University New Orleans. His work on Wallace has appeared in Critique, The Smart Set, and elsewhere.
Alex Moran completed his Ph.D. with the University of Birmingham in 2017. He has an article on Wallace in Orbit and an article on Colson Whitehead and Jennifer Egan coming out soon. He is currently writing an introductory volume to Egan's work, and lives in Southern California with his wife and dog.
Ándrea Laurencell Sheridan is an Associate Professor of English at Orange County Community College (New York), where she has been awarded both the President's Award for Excellence in Teaching as well as the SUNY Chancellor's Award for Excellence in Teaching (2018). She has earned an MA in English from SUNY New Paltz (2017), an MA in Humanities and Social Thought from NYU (2008), and a BA in English from Russell Sage College (2005). In addition to Wallace, her interests include 21st-century American fiction, metafiction, metamodernism, metamaterialism, metametaism, and her pit bull, Sadie. She has recently been accepted to the PhD program in Humanities at Salve Regina University and will begin in Fall 2019.
Dr. Robert Short earned his PhD at the University of Florida in 2017. His dissertation is titled Big Books: Addiction and Recovery in the Novels of David Foster Wallace. His work on Wallace has appeared in Normal 2015: Selected Works from the Second Annual David Foster Wallace Conference and on the website for James Ponsoldt's film The End of the Tour.


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OK, a Hot Stove League has finally resumed play after a extensive hiatus. The New York Mets reopened a free-agent marketplace by bringing behind Jay Bruce with a three-year, $39 million contract.
That seems like a reasonable understanding for a Mets, ESPN.com did lift counterpoints:
- Although Bruce strike 60 homers a final dual seasons, he also delivered a .317 on bottom percentage, that good next normal for right fielders.
- The Mets already had Yoenis Cespedes and Michael Conforto to play a dilemma outfield posts.
- Bruce is a below-average baserunner.
- Bruce's fielding metrics have been all over a place, trimming from OK to terrible. This signing also moves Conforto to core margin during slightest some of a time, that could also be cryptic defensively.
But Bruce, who turns 31 on Apr 3, still got decent income for one-dimensional outfielder in a twilight of his career. He should yield one some-more impulse for Randal Grichuk as he tries to conflict his approach into a unchanging purpose somewhere.
This signing doubtlessly eased a angst of a many unsigned giveaway agents watchful out a market. The Athletic columnist Ken Rosenthal offering this take on that:
An central from Major League Baseball voiced minimal regard Sunday, saying, "the players will get their money." By Opening Day, a surprising inlet of this marketplace indeed competence be remembered as small some-more than an aberration. (Scott) Boras, who represents several of a tip giveaway agents, including initial baseman Eric Hosmer, outfielder J.D. Martinez and right-hander Jake Arrieta, is exhibiting his common steely calm while posterior top-of-the-market contracts. The Yankees, Dodgers and other clubs are perplexing to get underneath a oppulance taxation threshold so they can reset their chastisement rate to a smallest for a distant higher category of 2018-19 — a category approaching to bleed an tear of spending.
Some on a players' side, though, take a some-more asocial view, citing a miss of rendezvous between clubs and many giveaway agents as an denote of probable collusion by a owners to illegally subdue giveaway representative salaries. Baseball's story of collusion — a owners paid a players $280 million to settle 3 cases in 1990 and another $12 million to residence other allegations though an acknowledgment of shame in 2006 — causes some actor member to conflict roughly reflexively to any hiccup in a market. As recently as 2010, a players lifted concerns about collusion, though zero specific came of those allegations.
Here is what folks are essay about a clogged marketplace:
Will Leitch, Sports on Earth: "Whatever your thoughts on a home run epidemic, a one thing a blast did was diminution a value of any sold home run. The home run is a best thing we can do in any sold at-bat, though compared to other home runs, they usually meant a small reduction than they have in a past. And as a free-agent deteriorate continues to stubbornly exclude to thaw, it is value looking during how it is inspiring a market. This year, there are 3 players who finished in a tip 10 in home runs who became giveaway agents during a finish of a 2017 season: J.D. Martinez, Logan Morrison and Mike Moustakas. None of them have been sealed yet. Tellingly, dual of them are in critical risk of carrying their marketplace collapsing all together: While a Red Sox and Martinez continue to dance around any other, conjunction Morrison nor Moustakas has had most suggestive tie to any team. Morrison, in particular, has even been deliberate a intensity one-year discount pickup, or even half a platoon. That's arrange of crazy, right? Morrison strike 38 homers final year! (To go along with a .353 OBP, his best given his rookie year, by a way.)"
Ted Berg, USA Today: "Martinez is not deliberate a clever defensive outfielder, and he's approaching usually going to get worse in a margin as he ages. He's a good adequate hitter to assistance a group even though ever stepping feet in a outfield, though many clubs now seem to preference regulating a rotating DH mark to yield rest to their regulars. A Scott Boras client, Martinez is not approaching to come cheap, and investing 9 total in his services will meant committing large income over a prolonged tenure to a one-dimensional player. His one dimension usually happens to be flattering damn awesome."
Jay Jaffe, SI.com: "Martinez, who incited 30 on Aug 21, is entrance off a career year in that he strike .303/.376/.690 with 45 homers and a 166 OPS+ for a Tigers (who dealt him for 3 prospects on Jul 18) and a Diamondbacks. Only Giancarlo Stanton and Aaron Judge strike some-more homers, though nobody outdid Martinez's slugging percentage. Remarkably, he put adult those numbers in usually 119 games, carrying missed a initial 33 due to a sprained right foot. It was a second year in a quarrel that Martinez has missed roughly a entertain of a deteriorate due to injuries; in 2016, he was singular to 120 games by a non-displaced detonate of his right elbow, suffered while using into an outfield wall. Despite his absences, Martinez has proven to be a complicated hitter, during slightest given being expelled by a Astros—who drafted him in a 20th turn behind in 2008—in a open of 2014. To that point, he'd strike a scanty .251/.300/.387 in 3 years (2011–13) with Houston, though in Detroit, he revamped his mechanics, adjusting his pitch craft to keep his bat in a strike section longer and beget some-more loft on a ball. From 2014–17, he strike a total .300/.362/.574 for a 149 OPS+; among players with during slightest 1,000 PA in that span, that's tied with a since-retired David Ortiz and Arizona teammate Paul Goldschmidt for fourth in a majors, behind usually Mike Trout (175), Joey Votto (163) and Stanton (154)."
Andrew Baggarly, The Athletic: "No matter what they do to residence a roster, a Giants positively contingency restock their system, and get younger and some-more athletic. You don't deposit in overhauling your actor growth complement usually to punt breeze picks. That would be like shopping a Ferrari and slicing adult your gas card. You have to put something in to get something out. But signing J.D. Martinez, who requires no breeze picks? Sure, because not?Trading for a year of (Andrew) McCutchen, and holding on his salary? Who's interlude them? And because stop there? Could we suppose Yu Darvish fasten a Giants revolution with Madison Bumgarner, Johnny Cueto and Jeff Samardzija?"
"They're gonna have games where they shillelagh people. But we have some right-handed energy arms that we consider will assistance opposite them, so they shouldn't kick us adult as most as some other teams that have those soft-tossing lefties."
Cleveland Indians manager Terry Francona, on a New York Yankees.


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Category:People from Guria
|Wikimedia Commons has media related to People from Guria.
Pages in category "People from Guria"
The following 21 pages are in this category, out of 21 total. This list may not reflect recent changes (learn more).
|Wikimedia Commons has media related to People from Guria.
The following 21 pages are in this category, out of 21 total. This list may not reflect recent changes (learn more).
1. Noe Zhordania – Noe Zhordania born January 141868 and dead January 11,1953, was a Georgian journalist and Menshevik politician. There Zhordania led the government-in-exile until his death in 1953, Zhordania was born on 14 January 1868, to a petty landowner family living in the village of Lanchkhuti in Guria, western Georgia, then part of the Kutaisi Governorate of Imperial Russia. According to the Radjeb Zhordania, grandson of Noe Zhordania, his lineage back to three Italian friends who emigrated from Genova to Georgia. One of them was a gardener and the others were merchants, one moved in Samegrelo and became the ancestor of the Zhordanias from the Tsaishi. Another moved in Arkhaveti and his descendants are the Zhordanias from Arkhaveti, the third was granted serfs and estates from the House of Gurieli in Lanchkhuti, and so remained in Guria. He was the ancestor of the Zhordanias from Lanchkhuti, including Radjeb Zhordania, in his early years Radjab became an orphan and he was taken in Samegrelo by his uncles. Later he returned in his hometown Lanchkhuti, but he was not welcomed by the relatives, thus, after moving in Shukhuti he demanded his share of the property from the relatives. He was given the land, where he built the Oda, married the daughter of Apakidze, later he participated in the Crimean War, where he received the rank of captain and where he was later killed. He had four sons, Butchu, Potine, Niko and Iosef, Niko, father of Noe and Gulchino Zhordania, was the village scriber, and lawyer and mediator in court. Kristine Chikovani, mother of Noe, was from the Samegrelo and he had his primary education in a Lanchkhuti public school. Afterwards, he graduated from the Ozugreti Orthodox Theological Academy and he then moved to Tbilisi where he graduated from the Georgian Orthodox Theological Seminary, a prestigious academic institution at the time. However, while Noes parents hoped that their child would become a priest and he wrote, God is Nature herself, as for a white-bearded deity, seated upon a throne, such a personage simply does not exist. I thought to myself, If Natures lord and master is Nature itself, then who is the rightful lord, the general opinion was that the Tsar was the lord over the people, and that the Tsar was himself appointed by God. But if God did not exist any more, the Tsar could not be his representative, I was therefore at a loss to understand by whose command and authority he sat upon his throne. In the Academy he was the head of a student association that was opposing the drawbacks of the present situation in Academy. In 1891 he moved to Warsaw, Poland, and attended the Warsaw Veterinarian Institute, during this period young Zhordania understood the basics of Marxism. In his memories Zhordania described his political evolution in 1892 as a reflection of Russias transition from socialism to Marxism, specifically he meant the period after 1891, when he left his homeland to continue his studies abroad. With Filipp Makharadze, Noe Zhordania started a correspondence with other Georgian intellectuals, namely Silvester Dzhibladze and Egnate Ninoshvili
2. Shalva Kikodze – Shalva Kikodze was a Georgian expressionist painter, graphic artist and theatre decorator. Together with Lado Gudiashvili and David Kakabadze, he is considered a key figure in Georgian art of the early 20th century and he was born in a remote Georgian village Bakhvi, Guria, then part of the Russian Empire. From 1914 to 1918, he studied at Moscow School of Painting, in 1916, he took part in an expedition to the Georgian village Nabakhtevi and made copies of the 15th-century murals from the local church. He stayed in his motherland for a period of 1918-1920. Afterwards he moved to Paris, where he, together with his fellow painters, Gudiashvili and Kakabadze and he died in Freiburg, Germany, on November 7,1921 Most of his works are now on display at the Art Museum of Georgia, Tbilisi, Georgia. "Khevsureti",1920 "Luxembourg Garden",1920 "Gurian woman holding a jar in her hand",1921 "Ajarian women in chadors",1921 "In the restaurant",1921
3. Filipp Makharadze – Filipp Makharadze was a Georgian Bolshevik revolutionary and government official. Born in the village of Shemokmedi, he studied at the Theological Seminary in Tbilisi and he joined the Social Democratic movement in 1891 and participated in activities in Georgia and Azerbaijan. In 1907-1915, he led various Bolshevik groups in Transcaucasia and, after the February Revolution, in April 1917, he was elected as a delegate to the 7th RSDRP Conference and served in the Bolshevik Caucasian Region Committee. In 1919-1920, he led Bolshevik groups resisting the Menshevik government of independent Georgia, after the Soviet takeover of Georgia, he became chairman of the Georgian Revolutionary Committee in February 1921 and then directed the Georgian Central Executive Committee. In 1922, Makharadze was involved in the Georgian Affair and opposed Sergo Ordzhonikidze's designs in respect to Georgia, over the next decade, Makharadze headed the Transcaucasian SFSR Gosplan, the Georgian Council of People's Commissars and the Transcaucasian SFSR Central Executive Committee. In 1938, he became the Chairman of the Presidium of Supreme Soviet of the Georgian SSR and he attended the 12-18th Congresses of the Communist Party and directed the Institute of Marxism–Leninism
4. Vladimir Nemirovich-Danchenko – Vladimir Ivanovich Nemirovich-Danchenko was born into a mixed Ukrainian-Armenian family in the village of Shemokmedi near Ozurgeti. His father was an officer of the Russian army, and his mother and he was educated at High school in Tbilisi and then at Moscow State University. In 1879 he left the University for the theatre, starting as a critic, and in 1881, his first play Dog-rose. He was a teacher of Moskvin, Knipper and Meyerhold, in 1919 he established the Musical Theatre of the Moscow Art Theatre, which was reformed into the Nemirovich-Danchenko Musical Theatre in 1926. In 1943 Nemirovich-Danchenko established the Moscow Art Theatre School, which is still extant, Nemirovich-Danchenko opened for theatre a true sense of Chekhov and Gorky plays, a prose of Dostoevsky and Tolstoy. It has been said that If Stanislavsky was the soul of Art Theatre, Nemirovich-Danchenko created an acting and directing style of the Moscow Art Theatre, actors ensemble and atmosphere. Because of this the Moscow Art Theatre was considered the best theatre of the world at that time, but Nemirovich didnt write down his system of acting and we know only the system of Stanislavski. He was one of the first recipients of the title of Peoples Artist of the USSR in 1936, later, he was awarded the USSR State Prize, the Order of Lenin, and Order of the Red Banner of Labour. The Brothers Karamazov Resurrection Anna Karenina Three Sisters Vladimir Nemirovich-Danchenko, Biography from Answers. com
5. Guria – Guria is a region in Georgia, in the western part of the country, bordered by the eastern end of the Black Sea. The region has a population of 113,000, with Ozurgeti as the regional capital, Guria is bordered by Samegrelo to the north-west, Imereti to the north, Samtskhe-Javakheti to the east, Ajaria to the south, and the Black Sea to the west. The province has an area of 2,033 km², Guria is traversed by the northeasterly line of equal latitude and longitude. Guria consists of three municipalities, Ozurgeti Lanchkhuti Chokhatauri The toponym Guria is first attested in the c.800 Georgian chronicle of Pseudo-Juansher. The principality, comprising modern Guria and much of Adjara with the city of Batumi, was reduced in size. There were uprisings against Russian rule in 1819 and again in 1841, in 1840, Guria was made a county and renamed Ozurgeti, after one of its main towns. In 1846, it was transferred to the new Kutais Governorate, by 1904, the population was just under 100,000, occupying an area of approximately 532,000 acres of mountains and swampy valleys, covered by corn fields, vineyards, and some tea plantations. The peasants' self-government, the so-called Gurian Republic, survived into 1906, the region was a native powerbase of the Georgian Social Democratic Party which dominated the Democratic Republic of Georgia from 1918 to 1921. Guria was a scene of guerrilla resistance to the militarily imposed Soviet rule early in the 1920s, under the Soviet government, Guria was an agrarian area divided into three administrative districts. In 1995, the Georgian government decreed the creation of the region of Guria, the Orthodox churches of Likhauri and Shemokmedi are the main historical buildings in the province. According to an explanation, in the times of Georgia's prosperity. The linguistic evidence for the hypothesis is the Megrelian for "heart" – "guri". Subtropic farming and tourism is a mainstay of the region's economy, water is one of the Guria's main assets. The province is famous for the water of Nabeglavi, which is similar to Borjomi in its chemical composition. Guria is also one of the largest tea growing regions in Georgia, the Gurians or Gurulebi is one of the ethnographical groups of Georgians, inhabiting Guria. Gurians are Orthodox Christian and speak the Gurian dialect of the Georgian language, gabriel Kikodze, the Bishop of Imereti. Noe Zhordania, Prime Minister of the Democratic Republic of Georgia from 1918 to 1921, pavle Ingorokva, historian, philologist, and public benefactor
6. Vasilij Kvachantiradze – Vasil Kvachantiradze was a top Soviet sniper during World War II. Kvachantiradze was born in a village in the Georgian region of Guria, however, his idea of travelling to Moscow for starting up a business career fell short when the war started. In 1941 Kvachantiradze joined the Red Army, soon he was set in as a sniper of the same detachments, 259th infantry Regiment and scored his first kills. While the greater number is in fact also referred as to confirmed kills by different sources as total amount of fatal shots and his victims were mainly officers but also soldiers, including enemy sharpshooters and snipers. Kvachantiradze managed to improvise traps and ambushes without exposing his position a single time, the morale of the German soldiers was wavering by deadly sniper fire. Alone there, Kvachantiradze scored around 44-60 kills, thus a Soviet counterattack was made possible. What did happen, when a combined Soviet infantry and mechanized assault could break through the circle easily, Kvachantiradze left the army in 1945 and became chairman in the Supreme Soviet Presidium USSR of the Soviet Kolkhoz. Vasilij Shalvovich Kvachantiradze died on February 9,1950 at the age of 43, snipers of the Soviet Union List of Georgians
7. Kita Abashidze – Prince Kita Abashidze was a Georgian literary critic, journalist, and politician. Abashidze was born into a family in the province of Guria. Having graduated from Kutaisi Classic Gymnasium, he attended the lectures in philosophy and art theory in Paris, later in the 1890s, he worked for the Tiflis control chamber, and then as an arbitrator in Racha and Chiatura in western Georgia. From 1893 onward, he engaged in journalism and regularly wrote literary criticism for Georgian press and his aesthetics and views on the contemporary Georgian and world literature were shaped under the influence of the Georgian intellectuals of the 1860s and the French critic Ferdinand Brunetière. In the early 1900s, Abashidze was involved in the management of Chiatura manganese industry and he also joined the Georgian Socialist-Federalist Revolutionary Party and became one of its leaders. In March 1917, he was replaced in the Ozakom with the Social-Democrat Akaki Chkhenkeli
8. Konstantin Leselidze – Konstantin Nikolaevich Leselidze, was a Colonel-General and Hero of the Soviet Union who distinguished himself at the North, Transcaucasus and Ukrainian front during World War II. He was also the brother of Viktor Nikolaevich Leselidze Leselidze was born on October 2 or 15,1903 in Ozurgeti. He was the brother of another decorated warhero, colonel Victor Leselidze who also died in the same year of the war. In May 1921 after graduating high school in Tbilisi Leselidze joined the Red Army and was deployed primarily in Georgia. Leselidze was member of the All-Union Communist Party Bolsheviks already since 1925, during the period of 1922 to 1938 he commanded artillery units from batteries to regiments and the Georgian Joint Military School. In June 1938 he got appointed to chief of artillery, infantry division and was active during the Soviet invasion of Poland in 1939, from February 1941 to the outbreak of hostilities, colonel Leselidze was chief of artillery, rifle corps in the Belorussian Special Military District. In the first year of war, colonel Leselidze remained in command of the artillery in the 2nd infantry corps, in June 1942 he became commander of the 3rd Infantry Corps, 46th Army of the Transcaucasus Front. Only two months later, Leselidze was promoted to general and given command over the 46th Army. The troops under his command exposed great bravery and Leselidzes tactics managed to defend the Caucasus from Wehrmacht takeover and his forces did also claim a foothold on the Kerch Peninsula, north-east of Kerch itself. In Tbilisi, a street in the center of the city was named after General Leselidze, streets were named after him in the cities of Batumi, Sochi, Novorossiysk and Gelendzhik. Советская военная энциклопедия / под ред, Великая Отечественная война1941 —1945. Герои Советского Союза, Краткий биографический словарь / Пред, — Т.1 /Абаев — Любичев/. № в РКП 87-95382 Коллектив авторов, Военный биографический словарь / Под общей ред. — ISBN 5-86090-113-5 National archives of Georgia Personal fund #1777 of Colonel-General K. Leselidze, inventory #1, in the building, which is located on this street, during January-February of 1944 housed the headquarters of the 18th Army


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Norma Jean Fruehauf
Norma was born on November 28, 1931 and passed away on Thursday, October 13, 2016.
Norma was a resident of Schoolcraft, Michigan.
VisitationWhen Monday October 17th 2016 3:00pm - 7:00pm LocationAvink Funeral Home Cremation Society Address129 S. GrandSchoolcraft MI49087Map Additional Information Cremation has taken place. Interment InformationLocationVicksburg Cemetery AddressVicksburg MI.


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The Mosteiro dos Jerónimos is a must see for visitors to Lisbon.
The monastery was started by the order of Manuel I (1515-1521) and was meant to commemorate Vasco da Gama's voyage to India and his successful return. Vasco da Gama, along with other great figures in Portuguese history, are entombed at the monastery.
The monastery is located in the Belém district, and is considered to be one of the most important sites in the city. In 1983 it was designated as a World Heritage Site by UNESCO, along with the nearby Belém Tower.
The monastery is easily reached via the tram number 15E. For more information on Mosteiro dos Jerónimos, click here.
Book a private tour! You may want to consider booking a private tour with an English-speaking guide. Your personal guide can provide you with information on the city and its historic sites. For more information on our Lisbon Panoramic tour, click here, and for information on all of our Lisbon tours, click here.
Photo credit: © Turismo de Lisboa • All rights reserved.
As usual, thanks for reading. Please visit International Lodging Corporation at our home page.


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American Flags around Amagansett NY 11930 – Proudly Made in USA
Short History of the American Flag
Retiring your Old American Flag
Which Flag is Right for You?
American Flags made in America
Unlike various other nations, USA just has two national icons: the bald eagle, and also the American flag. While the bald eagle is internationally recognized, the American flag is a symbol recognized worldwide. The flag has been the inspiration for vacations, music, poems, stories, art as well as more. It has actually been used to show nationalism, rebellion as well as whatever inbetween. The flag is so crucial that its history informs the story of America itself.
The American flag contains thirteen alternate straight stripes of equal width, which 7 are red and 6 are white. In the upper-left edge, also known as the canton, is a blue rectangle, on which are drawn fifty white five-pointed stars.
The American flag was taken on formally in 1777, at that time there was no meaning attached to the colors. The very same colors were utilized in developing the Seal of the United States of America in 1782, having certain meaning. The definition behind the colors of the flag are as adheres to:
"White signifies pureness and also virtue.
Red, strength & valor.
Blue, signifies vigilance, determination & justice".
Since 1777 when it was first embraced formally, the American flag has actually undertaken several modifications to reach its current style.
Brief History of the American Flag
The history of our flag is as remarkable as that of the nation itself. It has actually endured fights, motivated songs and also progressed in reaction to the development of the country it stands for. The following is a collection of intriguing facts as well as customs regarding the American flag and exactly how it is to be shown:
- The flag is usually displayed from sunup to sunset. In stormy climate, the flag need not be flown.
- The flag should be displayed day-to-day and on all holidays, weather allowing, on or near the main administration buildings of all public institutions. It needs to likewise be presented in or near every polling place on political election days and in or near every schoolhouse throughout institution days.
- When shown flat against a wall or a window, or in an upright alignment, the "Union" field of stars must be uppermost and also to the left of the onlooker.
- When the flag is elevated or lowered as part of a ceremony, and as it passes by in ceremony or review, everyone, other than those in attire, ought to face the flag with the right-hand man over the heart.
- The United States flag must never ever be dipped towards anybody or things, nor should the flag ever touch anything underneath it.
Over the years, extensive standards have actually been put in place for exactly how to deal with the flag. You could see some individuals are even brought to tears when the flag is honored at ceremonies and events.
The flag might be enhanced with golden edge bordering the border of the flag as long as it does not ruin the flag proper. Ceremonial displays of the flag, such as those in parades or on indoor posts, typically utilize fringe to enhance the appearance of the flag. When the flag is affixed to the right side of an automobile of any kind of kind (e.g. cars), it should be placed so that the "Union" is in the direction of the front of the car, as if the flag were streaming backwards from its hoist as the car moves forward. Consequently, American flag stickers on the right sides of automobiles might appear to be reversed, with the union to the onlooker's right instead of left as even more commonly seen.
On June 14, 1777, the Continental Congress passed an act establishing a main flag for the new country. The resolution stated: "Resolved, that the flag of the United States be thirteen stripes, alternating red and white; that the union be thirteen stars, white in a blue field, representing a new constellation." On Aug. 3, 1949, President Harry S. Truman formally declared June 14 as Flag Day.
Retiring your Old American Flag
The majority of American Legion Posts on a regular basis conduct a dignified flag burning event, often on Flag Day, June 14th. Many Cub Scout Packs, Boy Scout Troops, as well as Girl Scout Troops retire flags on a regular basis. Call your local American Legion Hall or Scout Troop in New York state to inquire about the schedule of this service.
Which Flag is Right for You?
There is a big option of American flags to select from consisting of hand flags, interior flags, banner flags as well as outside flags from various vendors. Whether you're looking for an excellent bargain on hand flags to offer out throughout a ceremony or would like to spend in a high-grade outside flag to display at your organisation, there's definitely a flag matched for you.
Printed vs Fully Sewn Flag – A printed flag is a picture that is published on the nylon product. A stitched flag is made by joining the individual pieces of tinted textile with thread.
Chain vs Lock Stitch – A chain sewed flag will entirely unravel if one string is torn, but that won't occur with a lock stitched flag.
G-SPEC Flag – The G-SPEC flag is for usage by the U.S. federal government. The sizes are made to the main government hoist fly ratio of 1:1.9. The star fields are larger and they are primarily acquired for display at military bases.
American Flags made in America
Look for flag suppliers that are participants of the Flag Manufacturers Association of America which established the "Certified Made in the U.S.A" accreditation program of American Flags. Based on the FMAA website," 'Certified Made in the U.S.A.' accredits that your American flag has been made in the United States of products that are residential in origin and that all procedures in every step of its manufacture were finished in U.S. centers with U.S. labor".
ZIP codes in Amagansett we serve: 11930


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MONTCLAIR, NJ - This Saturday, February 11, from 10am-1pm, the Montclair Justice Coalition will host a second public session that brings together residents and community leaders to work on issues that affect residents every day.
The event is set to take place at the George Inness Annex at Montclair High School, located at 141 Park Street.
During the first public forum in December, dozens of people identified areas of concern regarding race, class, police-youth relations, housing, education and community engagement. This session will begin the process of putting words into action.
Organizers have stated that they will work on issues identified in the forum, identify additional concerns, and distribute tasks that participants can complete in the coming weeks. From community outreach to research, writing, logistics, and simply bringing a friend, there is something everyone can do to help make a better Montclair.
Questions can be directed to firstname.lastname@example.com


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Case Reports in Dermatological Medicine
Volume 2014, Article ID 452720, 3 pages
Acquired Brachial Cutaneous Dyschromatosis in a 60-Year-Old Male: A Case Report and Review of the Literature
Department of Dermatology, Jefferson Medical College, Thomas Jefferson University, 833 Chestnut Street, Suite 740, Philadelphia, PA 19107, USA
Received 1 July 2014; Accepted 17 December 2014; Published 31 December 2014
Academic Editor: Alireza Firooz
Copyright © 2014 Nadia Abidi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Acquired brachial cutaneous dyschromatosis is an acquired pigmentary disorder that has been described in only 20 patients but likely affects many more. This case of a man with acquired brachial cutaneous dyschromatosis is unique as most reports are in women. We report the case of a 60-year-old male who presents with an asymptomatic eruption characterized by hyperpigmented and telangiectatic macules coalescing into patches on the bilateral extensor aspects of the forearms which is consistent clinically and histopathologically with acquired brachial cutaneous dyschromatosis. Given its presence in patients with clinical evidence of chronic sun exposure and its histopathological finding of solar elastosis, acquired brachial cutaneous dyschromatosis is likely a disorder caused by cumulative UV damage. However, a possible association between angiotensin-converting enzyme inhibitors and acquired brachial cutaneous dyschromatosis exists. Further investigation is needed to elucidate both the pathogenesis of the disorder and forms of effective management. Treatment of the disorder should begin with current established treatments for disorders of dyspigmentation.
1. Case Report
A 60-year-old male presented for an annual skin examination. Physical exam incidentally revealed two large, well-delineated patches on the bilateral forearms comprised of hyperpigmented, hypopigmented, telangiectatic, and slightly atrophic macules (Figures 1 and 2). Superficial telangiectasias were also present on the neck and anterior chest. The patient was unsure as to when the forearm lesions first appeared but reported a gradual onset and progressive course over several years. On further questioning he denied any associated symptoms. The patient reported a 25-year history of chronic sun exposure secondary to his profession as a fleet service agent handling aircraft cargo transport outdoors. He denied using any consistent form of photoprotection in the form of sunscreen or physical barriers.
The patient is Fitzpatrick skin type III. Past medical history included hypertension, hyperlipidemia, type 2 diabetes mellitus, asthma, and a history of basal cell carcinoma. Current medications include amlodipine/benazepril, which the patient had been taking since his diagnosis of hypertension six years earlier, chlorthalidone, rosuvastatin, metformin, and inhaled mometasone.
Potassium hydroxide (KOH) preparation on lesion scrapings, performed to rule out underlying fungal infection, was negative. A punch biopsy was obtained from a representative patch on the forearm. Biopsy of the lesion revealed epidermal atrophy with blunting of the rete ridges. There was increased pigmentation of the basal layer without melanin incontinence. There were prominent superficial blood vessels (Figure 3).
2. Discussion
Acquired brachial cutaneous dyschromatosis (ABCD) is an acquired disorder of pigmentation of the skin that presents as asymptomatic, gray-brown patches with an irregular geographical border, interspersed with hypopigmented macules on the dorsal aspect of the forearms [1]. It is usually bilateral and distally distributed. On histology, ABCD is characterized by a poikilodermatous-like tissue pattern with epidermal atrophy, increased basal layer pigmentation, solar elastosis, and superficial telangiectases [1–3]. However, unlike poikiloderma, no pigmentary incontinence is seen [1–3]. It has been reported most frequently in middle-aged, postmenopausal women with Fitzpatrick skin types III-IV [1]. Additionally, an association with poikiloderma of Civatte has been found in 45% of cases [1].
The differential diagnosis includes melasma, tinea versicolor, and other disorders of pigmentation. Melasma is comprised of sharply delineated, hyperpigmented macules and patches found primarily on the malar eminences, forehead, upper lip, and mandible of women. It is similar to ABCD histologically in that there is increased basal layer pigmentation, but there is no epidermal atrophy or telangiectasia. Tinea versicolor is characterized by hyper- and hypopigmented macules and patches with fine scale and is commonly found on the neck and trunk in a seborrheic distribution. It is easily diagnosed by microscopic examination of KOH-dissolved scale. Other pigmentary disorders could look similar clinically but they are discernable by histologic examination. Lichen planus pigmentosus (LPP) is characterized by grey to dark brown macules in sun exposed areas such as the face, neck, trunk, and limbs and in sun-protected sites such as the flexural folds [4]. Erythema dyschromicum perstans (EDP) is characterized by asymptomatic, grayish macules involving the trunk and proximal extremities [5]. For both entities, the color is distinctive and different from ABCD and histologically these conditions show interface dermatitis, melanophages, and variability in epidermal change and inflammatory infiltrate [4, 6].
Finally, drugs are known to cause pigmentary disorders and they include nonsteroidal anti-inflammatory drugs, antimalarials, amiodarone, cytotoxic drugs, tetracyclines, heavy metals, and psychotropic drugs [7]. Thorough history distinguished drug-induced hyperpigmentation from ABCD in our patient.
Currently, two hypotheses on the etiopathogenesis of ABCD exist. In its first description in the literature by Rongioletti and Rebora, authors observed a large proportion of their cohort (65%) suffered from hypertension and had been taking antihypertensive drugs for years prior to the onset of the pigmentation—with angiotensin-converting enzyme inhibitors (ACEIs) being the most commonly used [1]. These findings led to the hypothesis of a direct association of ABCD with hypertension and/or with antihypertensive—specifically ACEI—use [1]. Later, Hu et al. disputed over this conclusion, suggesting the association between ABCD and hypertension or antihypertensives as more likely a consequence of the commonality of hypertension and its treatment regimens [2]. Instead, due to its histopathological resemblance to poikiloderma of Civatte, in which epidermal atrophy, hyperpigmentation, and telangiectasias are also seen, Hu et al. suggest the disorder is a manifestation of chronic sun damage—either due to cumulative UV exposure or a pattern produced by drug-induced (possibly ACE-I induced) photosensitivity [2].
Although drug induced pigmentation represents 10–20% of all acquired hyperpigmentation [8], there is currently no data associating ACEIs and cutaneous dyschromia. However, one study reports photosensitivity as an adverse cutaneous reaction to ACEI use [9], therefore potentially backing Hu et al.'s two-hit drug-induced photosensitivity hypothesis. In this case, our patient's long-standing hypertension, use of an ACEI, and chronic sun exposure lend support to either proposed hypothesis.
Though not uncommon according to Rebora and Rongioletti, ABCD is subtle and asymptomatic and thus likely underreported; as such, there is little known about successful treatments. Established treatments for other acquired forms of dyspigmentation, including topical depigmenting agents, chemical peels, and laser treatments, may be considered [10]. To obtain satisfactory cosmetic results, treatment of cutaneous hyperpigmentation often requires the combination of multiple modalities of treatment as well as strict photoprotection. In a 2010 review, authors reported significantly greater improvements in skin pigmentation disorders with treatment using nonablative and ablative fractional photothermolysis (NAFP and AFP) in comparison to treatment with other resurfacing devices [11]. One study utilizing AFP for treatment of poikiloderma of Civatte observed a 65.0% improvement in erythema/telangiectasia and a 66.7% improvement in dyschromia with the average number of 1.4 treatments required for improvement. Due to the histopathological similarities seen in ABCD and poikiloderma of Civatte, we expect that a series of AFP treatments for our patient would result in similar improvement.
In summary, we describe a case of acquired brachial cutaneous dyschromatosis in a 60-year-old male with a history of hypertension, ACEI use, and chronic sun exposure. In most reported cases thus far, individuals have had some evidence of chronic sun exposure either histologically with the presence of solar elastosis or clinically with the presence of poikiloderma of Civatte. Although this most likely indicates a primary sun-exposure component to the etiology of ABCD, pathogenesis via ACEI-induced photosensitivity remains to be investigated. To determine appropriate treatments for ABCD, trials in its management are needed and should be guided by current forms of treatment used for other pigmentation disorders, including topical depigmenting agents, chemical peels, laser treatments, and strict photoprotection.
Conflict of Interests
J. Sahu served as a consultant to Celgene. The authors declare that there is no other conflict of interests regarding the publication of this paper.
- F. Rongioletti and A. Rebora, "Acquired brachial cutaneous dyschromatosis: a common pigmentary disorder of the arm in middle-aged women," Journal of the American Academy of Dermatology, vol. 42, no. 4, pp. 680–684, 2000. View at Publisher · View at Google Scholar · View at Scopus
- S. W. Hu, J. Chu, S. Meehan, H. Kamino, and M. K. Pomeranz, "Acquired brachial cutaneous dyschromatosis," Dermatology Online Journal, vol. 17, no. 10, article 16, 2011, http://escholarship.org/uc/item/09r7454f. View at Google Scholar
- D. Lipsker, "What is poikiloderma?" Dermatology, vol. 207, no. 3, pp. 243–245, 2003. View at Publisher · View at Google Scholar · View at Scopus
- M. E. Vega, L. Waxtein, R. Arenas, M. T. Hojyo, and L. Dominguez-Soto, "Ashy dermatosis versus lichen planus pigmentosus: a controversial matter," International Journal of Dermatology, vol. 31, no. 2, pp. 87–88, 1992. View at Publisher · View at Google Scholar · View at Scopus
- T. F. Cestari, L. P. Dantas, and J. C. Boza, "Acquired hyperpigmentations," Anais Brasileiros de Dermatologia, vol. 89, no. 1, pp. 11–25, 2014. View at Publisher · View at Google Scholar
- L. D. Soto, M. E. V. Memije, R. Arenas, and L. W. Morgenstein, "Dermatosis cinecienta. A clinico-pathological study of 20 patients (1989–1990)," Gaceta Médica de México, vol. 128, no. 6, pp. 623–628, 1992. View at Google Scholar · View at Scopus
- D. Dereure, "Drug-induced skin pigmentation," American Journal of Clinical Dermatology, vol. 2, no. 4, pp. 253–262, 2001. View at Publisher · View at Google Scholar
- O. Dereure, "Drug-induced skin pigmentation epidemiology, diagnosis and treatment," The American Journal of Clinical Dermatology, vol. 2, no. 4, pp. 253–262, 2001. View at Publisher · View at Google Scholar · View at Scopus
- U. M. Steckelings, M. Artuc, T. Wollschläger, S. Wiehstutz, and B. M. Henz, "Angiotensin-converting enzyme inhibitors as inducers of adverse cutaneous reactions," Acta Dermato-Venereologica, vol. 81, no. 5, pp. 321–325, 2001. View at Publisher · View at Google Scholar · View at Scopus
- M. Picardo and M. Carrera, "New and experimental treatments of cloasma and other hypermelanoses," Dermatologic Clinics, vol. 25, no. 3, pp. 353–362, 2007. View at Publisher · View at Google Scholar · View at Scopus
- E. P. Tierney and C. W. Hanke, "Review of the literature: treatment of dyspigmentation with fractionated resurfacing," Dermatologic Surgery, vol. 36, no. 10, pp. 1499–1508, 2010. View at Publisher · View at Google Scholar · View at Scopus


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Welcome! You are browsing as a guestCreate a free account to see 38 projects made from this pattern and more... What am I missing?
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Toe-up Baby Sock
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Learn Judy's magic cast on, the famous Fleegle heel (you'll love it!), and an invisible ribbed bind-off.
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April 24, 2012 16:04 ET
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