text:
When there are actually any statements queued up while in the transaction, conduct the subsequent methods for each queued up assertion while in the transaction, oldest to start with. Every single assertion has a statement, optionally a end result established callback, and optionally an mistake callback.
A SQLTransactionSync object is originally new, but It will probably be marked as stale the moment it's been dedicated or rolled back.
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text:
The lead up to the 2016 Games in Rio was a hot mess. It was a hot, stinky mess. Whether it was the backdrop the Brazil's political coup and economic fiasco, its tainted and literally foul water supply, its embarrassingly behind schedule and over budget building and infrastructure projects, or the public health crisis of the mosquito born Zika virus, many countries were not sure if they could safely travel to, let alone compete in Rio. Compound that with Russia being excluded from the games under a cloud of doping allegations and you had the perfect storm for an Olympic debacle of epic proportions for all the world to watch on their television screens and Twitter feeds from home.
Then, about a week into the games, the unthinkable happened. We loved it. We really, really loved it.
From the brutally honest telling of Brazil's tragic legacy of colonization and slavery in the opening ceremony, to Simone Biles leading her phenomenal team of gymnasts to all around gold, to Michael Phelps shattering a record held for over 2000 years and earning the gold for the fourth straight time, to the electric moment when Simone Manuel celebrated with Canadian teen sensation Penny Oleksiak as she tied with her become the first African American to win gold in the woman's 100 meter freestyle, we just cannot get enough.
It is as if only for a moment, we are just one people. For the blink of an eye, we are Americans, and maybe even global citizens, as we show grace, dignity and respect to each of our worthy competitors. For just about a week so far, we have let some – just some – of the divisive rhetoric of the political stage and even an iota of the legitimate pain and angst we personally feel become white noise and just fade into the background as we cheer for complete and total strangers. Of course, many of them wear our country's colors, but so many of the other global competitors whose heart and sportsmanship have so far dazzled and amazed us are from places that if you asked us a week ago, we either hadn't heard of, may have dismissed, or even maligned.
Some may look at the Olympics as nothing more than the world's re-enactment of the bread and circus of the Roman Empire. Nothing better suits the fanciful whims of the empire than putting the gladiators in the ring to distract us from the systemic oppression and pain of our real lives. To be honest, this is an argument that I am pretty sympathetic to, at least some of the time. It's true. If you think long and hard about the atrocities that many nations have done in their history, including and especially our own, the idea of athletes literally wrapping themselves in their country's flag can turn your stomach.
But then there is the sheer magic of it all. There is something about the Olympics that brings many of us the closest to witnessing an actual real life miracle than almost any other sporting event that I have ever seen. Beyond the pageantry of it all, being able to witness another human being push themselves to and maybe even beyond edge of their God given potential in so many different events is as humbling as it is awe inspiring. I am a grown man who is not really a crier (okay, definitely sometimes), but I cannot tell you how many times I found myself just welling up with tears of complete joy this week. And when I have talked to my friends the next day or see comments on social media, these were tears that we all shed together and this is a joy that we are all experiencing together.
When we see these Olympians, we gaze upon the ineffable splendor and glory of God in each of them and see the best of ourselves. And as God says in Genesis, "It was good. It was very good."
And yes, people were flipping out because Gabby Douglas was so happy after winning gold with her team that she forgot to put her hand over her heart during the national anthem, and the internet exploded over Michael Phelps' mean mug and his weird cupping spots, but these are precisely the flashes of momentary insanity that we have grown to expect from the interweb. And yes, Donald Trump did actually say that President Obama "founded ISIS". But, what else is new? No surprises here. We are, after all, a nation seemingly addicted racial bias and reality T.V.
What I think is surprising us though is how much we missed just being together, even if we are glued to our television screens, just so we can see the very best of who are and can be as a people when we actually chose to love and support one another, and give it our all. Rio only qualifies as bread and circus if it's purpose is to distract us from the reality of our lives. There's no denying that this is still a huge part of what is going on here. But I see happening on a deeper level is that seeing these outstanding human beings at their absolute personal best may not cause us to avoid reality, but may inspire us to confront our own.
We live in a world where words like grit, resilience and perseverance are increasingly thrown around more and more each day. But the grit that we are witnessing each night is more than the grit of individual performance. I think that the Olympics inspire us all to remember what we are actually capable of, not in service of some empire, or even just of ourselves, but of each other. To me the most beautiful sports in the Olympics are not the individual sports at all, but the team sports where we are reminded that we are only as strong as our love, support, and encouragement of one another.
So, thanks Rio. This first week has not been bad. Not bad at all.
Of course, we can do without Zika and some of the other drama you brought us, but I think that what we are finding in Rio is something that is more precious than all of the gold medals (though they are great) and even more than the pageantry, pomp, and circumstance. We are discovering in Rio something that we yearn for more than all of our our gadgets, our guns, or the fancy new gizmos of our increasingly interconnected but ever more isolated world. We have come to Rio to discover that there just might even be more to us than the political, ethnic, religious or even nationalistic fault lines of our time. In the tears of joy and the cheers for complete strangers both from home and abroad, we have come to Rio find each other.

subset: commoncrawl


text:
The comprehensive food
safety information website
Food Safety Engineer - CP Kelco - Tulsa, OK
= Food Safety Engineer(s)
· Maintain awareness of the food regulatory environment and emerging microorganisms of concern
· Provides support for areas such as CAPA/Nonconformance Investigations, Customer Complaints and Audits and leads validation of corrective actions that meet CAPA closed-loop regulatory requirements of FDA registered food or pharmaceutical manufacturing facilities.
· Leads the plant Food Safety Management System in a manner which will ensure compliance with regulatory, quality system and customer requirements. This includes a thorough evaluation of building infrastructure and expansion or upgrading facilities and food contact equipment to assure that quality and food safety are built into all new/upgraded equipment or structures.
· Supports the plant QA manager in continuous improvement activities of the Quality Management System
· Leads facilities with focus on cGMP and adequacy of the areas after the completion of the work and supervision to ensure that all the work was completed, and improvements to meet the GMP guidelines/food safety, commissioning and validation activities and evaluation of HACCP plans/HARPC.
· Leads all product adulteration incident reviews and provides leadership in micro management and sanitation excellence.
knowledge of FSMA Preventive Controls requirement and development of Food
Safety Plans with experience driving corrective actions of food safety issues
· Minimum of 1- 3 years experience in Food Microbiology, Process Development and Quality and Food Safety Management Systems
· Bachelor of Science Degree (i.e. Process Engineering, Chemistry, Microbiology, Food Safety) required;
· Certified HACCP manager required; Certified in Food Preventive Controls preferred
· Knowledge of food microbiology, good laboratory practice, food safety controls, manufacturing processes, sanitary design, food law, cGMP, auditing, troubleshooting and microbiological test procedures is required.
· Experienced with implementing management systems in the CPG Industry-ISO 9001, 22000, 22002 background with accomplishments in design and implementation
· Experience in QA, Quality and Food Safety Management Systems, New Product Development and Food or Pharmaceutical manufacturing
· Ability to create awareness to Food Safety regulations and execute programs and achieve goals to meet regulatory requirements.
· Experience in root cause analysis and CAPA
· Strong computer skills with proven proficiency in Microsoft Word, Excel, Power Point and flowcharting software
Copyright (C) All rights reserved under FoodHACCP.com
If you have any comments, please send your email to email@example.com


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product description page
I Fought the Law : Photographs of the Strangest Laws from Each of the 50 States (Hardcover)
About this item
Strange, outdated laws from each of the 50 U.S. states—some overturned, some still on the books, and some merely the stuff of legends—are depicted with sly wit by Olivia Locher. Incisive, ironic, and gorgeous, these images will appeal to art buffs and trivia fans alike. A foreword from American poet Kenneth Goldsmith and an interview with the artist by Eric Shiner, former director of the Andy Warhol Museum, contextualize rising-star Locher's photography. From serving wine in teacups in Kansas to licking a toad in Kentucky or perming a child's hair in Nebraska, breaking the law has never looked so good.
Number of Pages: 112
Genre: Photography, Freedom + Security / Law Enforcement
Sub-Genre: Law
Format: Hardcover
Publisher: Chronicle Books Llc
Language: English
Street Date: September 5, 2017
Item Number (DPCI): 248-42-2387
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MSRPReg: $16.95 Save $5.43 (32% off)
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text:
OAKLAND — Two new council members who learned that Town Manager Bernese Fleming hired a third police officer without telling council members for nearly a month say they may try to cut the department back to two officers.
The size of the force was a major issue in the recent election. As candidates, Mayor Francine Postell and council member Jeffrey Holton called the police department inefficient and said the town needs to improve productivity, not enlarge the force.


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22 photos
$299,900 24.8 acres 3 Beds | 2 Baths | 1450 sqft 281 Poutin House Lane, Stony Point, North Carolina 28678 - Alexander County
281 Poutin House Lane
Imagine living on a 24-acre mass of green. Green everywhere you look, some flat, some wooded, some sloped and all the wonderment of nature. Such is this mini-farm in Stony Point NC, minutes from I-40. Truly an emerald to the eye but only 1 hour from Charlottes International Airport. Acreages are not always equal in use and in locality. This property, however, has both quality in the land, and closeness to major interstates. You can arrive in Mooresville, a lively, vital and interesting city in 35 minutes. Mooresville is a Lake Norman Town and has the best in restaurants, marinas, medical care and shopping of all types. There are also local stores and shopping within 10-15 minutes of Stony Point. The farm and the surrounding land w
Julie Breedlove Exp Realty-Breedlove Farms, Estates & Land


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Mercy Corps China just launched the Global Philanthropy Information and China Project (GPICP). According to an email from Ms. Yimei Chen, Mercy Corps China Country Director, the purpose of the GPICP is to:
(I)ntroduce global philanthropy information to Chinese foundations and NGOs, and make Chinese information available to external readers.
The objectives will be to help break the isolation of Chinese philanthropy and social development from the world; raise Chinese capacity in strategic and effective philanthropy; and foster international exchanges and cooperation.
GPICP is really an enewsletter with bits and pieces of information about philanthropy in China. The current issue includes the feedback to the Bill Gates and Warren Buffett Pledge and provides summaries of several events in China, including the Second China Private Foundation Forum 2010, the first Jingshi Philanthropy Seminar in Beijing and news reports on trends in philanthropy.
To download the enewsletter, please click this link: Download GPIEN-C1English


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Siemens Careers
HR Data Management and Processes
Job Description
Business Unit: Information Technology
Requisition Number: 232091
Primary Location: United States-Pennsylvania-Malvern
Assignment Category: Full-time regular
Experience Level: Mid level
Education Required Level: Bachelor's Degree
Travel Required: 10%
Division Description:
At Siemens Healthineers, we are passionate about enabling healthcare professionals to deliver high quality patient care, and to do so affordably. A leading global med-tech company, Siemens Healthineers continues to strengthen our portfolio of medical imaging and laboratory diagnostics, while adding new offerings such as managed services, consulting, and healthcare IT services – as well as further technologies in the growing market for therapeutic and molecular diagnostics.
Siemens Healthineers develops innovations that support better patient outcomes with greater efficiencies, giving providers the confidence they need to meet the clinical, operational and financial challenges of a changing healthcare landscape.
For more information, please visit:
Job Description:
Position Overview
In your role as HR Data and admin process manger it is crucial to demonstrate both business process as well as technical skills with special focus on end-2-end processes and integrations. You consult and support Application and Service Managers regarding their implementations and are responsible to govern and steer global master data flows according to Healthineers business strategy.
· Act as a central point of reference for HR Master Data flows in collaboration with an international team
· Coordinate and drive state-of-the-art technologies & implementations to meet business requirements (end-2-end) in a global context including business analysis, coordination, vendor collaboration and quality documentation
· Implement and assume responsibility for on-premise and cloud integrations and required technology
· Consult and support Application / Service Managers in regards to data flows and technology
· Manage relationships with key business (HR and business both for Siemens Healthineers and Corporate where applicable) and IT internal stakeholders
· Actively seek and initiate opportunities for process improvement and continued value add toward business stakeholders
Required Knowledge/Skills, Education, and Experience
BS/BA in related discipline (or equivalent experience)
Knowledge and Experience:
· 3 – 5 years' experience with integration architecture and technologies for on-premise and/or SaaS solutions
· Ideally 3 – 5 years of know-how in SAP ERP HR module
· Experience within project implementations
· Strong understanding of HR processes and related data flows.
· and regulatory requirements related to Healthcare
· Ability to derive IT requirements out of Business process descriptions
· Advanced presentation skills eg. Trainings
Preferred Knowledge/Skills, Education, and Experience
· Experience working within Siemens/Healthineers
· Experience working within regulated environments
· Project Management experience within large/complex business driven projects
· Vendor/supplier management
· Technology know-how in regards to Data Exchange / Middleware and Software as a Service/ cloud


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text:
Flashcards in Virology: Herpesviruses Deck (51):
Describe the classification of Herpesviruses.
(family, subfam etc)
Family: Herpesviridae
Subfamilies: Alpha, Beta, Gamma herpesviridae
Size: 180-200nm
Envelope: YEP
Genome: linear dsDNA (120kb to 230kb)
Genome Replication: Nucleus
Virus assembly: Nucleus
Describe the structure of herpesviruses.
(glycoproteins, tegument etc)
- Glycoproteins: embedded in the lipid envelope. Receptor mediated entry into cells
- Tegument: between envelope and capsid, induction of viral gene expression, shutoff of host protein synthesis, virion assembly
- Icosadeltahedral capsid
- dsDNA
What are the 8 Human Herpesviruses?
1. Herpes simplex virus 1 (HSV-1)
2. Herpes simplex virus 2 (HSV-2)
3. Human cytomegalovirus (HCMV)
4. Varicella-zoster virus (VZV)
5. Epstein Barr virus (EBV)
6. Human herpesvirus 6A/6B (HHV-6A/6B)
7. Human herpesvirus 7 (HHV-7)
8. Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8)
What are the three subgroups of the Human Herpesviruses.
1. Alphaherpesvirinae
2. Betaherpesvirinae
3. Gammaherpesvirinae
Human Herpesvirus Subgroups:
1. Alphaherpesvirinae?
- variable host range
- short replication cycle
- rapid spread in culture
- efficient destruction of infected cells
Human Herpesvirus Subgroups:
2. Betaherpesvirinae?
- restricted host range
- long replication cycle
- slow spread in culture
Human Herpesvirus Subgroups:
3. Gammaherpesvirinae
- restricted host range
- usually specific for B or T lymphocytes
- Latent infection in lymphocytes
- replication in culture is infrequent
Describe the cellular tropsim of the following herpesviruses:
HSV-1, HSV-2, Varicella Zoster virus (VZV), Cytomegalovirus (CMV), Human herpesvirus 6 (HHV-6), Human herpesvirus 7 (HHV-7), Epstein Barr Virus (EBV) and Kaposi's Sarcoma-associated herpesvirus( HHV-8).
- Mucoepithelial cells for both simplex viruses.
-B lymphocyte and epithelial cells for VZV
- Epithelial cell, monocytes and lymphocytes for CMV
- T lymphocytes for both Human Herpesvirus 6 + 7
- B lymphocytes and epithelial cells for EBV
- B lymphocytes and endothelial cells for HHV-8.
What are the two parts of herpesvirus life cycles?
1. Latency: no virus protein expression(modified protein expression), episomal DNA replicated with host DNA aka copies of viral genome is passed on to the daughter cells, it is immunologically silent. Once you are infected it is there for your entire lifespan.
2. Lytic cycle: virus DNA replication, new progeny viruses made, full range of virus proteins expressed, highly immunogenic
Give a brief history of herpesvirus.
- described since ancient Greece
- herpes is derived from the greek word herpein which means to creep
-hippocrates and other greek scholars used the word Herpes to describe spreading cutaneous lesions.
What glycoproteins are involved with entry of herpesvirus into host cells?(5)
- five highly conserved glycoproteins
1. Glycoprotein B (gB)
2. Glycoprotein H (gH)
3. Glycoprotein L (gL)
4. Glycoprotein M (gM)
5. Glycoprotein N (gN)
What are the two ways Herpesvirus can bind and enter host cells?
- Receptor-mediated endocytosis -glycoproteins interact with receptors on cell and endocytosis occurs
- Direct fusion with the plasma membrane - interaction with receptors triggers direct fusion of the viral envelope and host cell membrane; capsid is released into the cell
Explain how EBV enters epithelial cells.
- a complex comprised of gp42, HLA, Class II, gH and gB is formed. This complex is called the fusion complex. It undergoes a rearrangement to bring VM into direct contact with the HCM for fusion to allow entry of the virus.
What are the steps for herpes simplex virus binding and entry into host cells?
1. Pre-fusion
2. Receptor binding
3. Fusion triggering
4. Fusion
Will all herpesviruses go lytic immediately following infection?Examples?
- Ex:
1. HSV/VZV infection ---> Lytic replication latency. If it goes to lytic it will either cause cell death or cell to cell transmission Lytic replication Latency. If it goes to lytic it will either cause cell death or cell to cell transmission
Explain herpesvirus lytic replication cascade.
- Immediate early : Immediate early transducers of lytic replication (alpha proteins) -> minimal number of proteins..interact with promoters for viral rep in lytic. Also interact with promotes of latent / structural genes.
- Early: Virus DNA replication (beta proteins)
- Late: Structural proteins (gamma proteins)
Do all herpesviruses encode their own protein which are necessary and sufficient for viral DNA replication?
- yes. Herpes all express the proteins required for rep and do not need host proteins etc for rep.
- This includes: ssDNA binding proteins, Origin binding protein, helicase-primase complex, DNA polymerase and polymerase processivity factor.
L> homologues exist for these host cell proteins in alpha(ex:HSV) , beta(ex: CMV) and gamma herpesviruses (ex: EBV)
Explain herpesvirus DNA replication.
- oriLyt
L> Origin of replication region
- Origin binding protein
- DNA unwinding
- Replication bubble formed from the unwinding of DNA
- ssDNA binding protein stabilizes the replication fork
- Helicase/Primase: origin binding proteins and ssDNA binding proteins recruit the viral DNA replication proteins to the replication forks.
- synthesis of new DNA strand via poly/accessory factor on the leading strand occurs and discontinuous synthesis occurs on the lagging strand with RNA primer filling the gaps (okasaki fragments)
Herpesvirus DNA replication, rolling circle?
- DNA is nicked to form a rolling circle.
- cleavage /packing proteins
- no one knows why this occurs.
- one strand is nicked by endonuclease. The free 3' end is extended by DNA poly (5'->3') displacing the comp temp strand which is copied in short segs by DNA poly
What are the clinical manifestations of herpes simplex 1 infections?
- Encephalitis
- conjunctivitis
- oropharyngeal herpes
- mucocutaneous disease (immunocompromised)
- primary genital herpes, recurrent herpes genitalis
- herpes whitlow
What are the clinical manifestations of herpes simplex 2 infections?
- meningitis
-oropharyngeal herpes
- perianal herpes
- primary genital herpes, recurrent herpes genetalis
- herpes whitlow
By examining the clinical manifestations of both HSV-1 and HSV-2 what conclusion can be drawn?
- that they have coevolved with us
Clinical manifestations of herpes simplex infections:
- Infection via what surfaces?
- replication occurs where?
- invasion?
- mucosal surfaces
-replication in oral or genital mucosa
- invasion via sensory nerve endings
Clinical manifestations of herpes simplex infections:
- what is HSV's two unique properties? Explain them.
1. Neurovirulence: Invade and replicate in the CNS, profound disease, severe neurologic devastation
2. Latency: HSV-1: trigeminal ganglion and HSV-2: sacral ganglia.
**** goes latent in dorsal root ganglion and can travel along nerves and invade CNS
Clinical manifestations of herpes simplex infections:
- Explain the immunocompromised situation.
- Transplants: severity directly related to type of immunosuppressive therapy
- pneumonitis, esophagitis and gastritis
- HIV/AIDS: more exaggerated, more frequent and more resistant to antivirals.
aka you can get diseases you would not normally see.
- allows replication out of control.
Clinical manifestations of herpes simplex infections:
- Explain the following states:
1. Healthy
2. Congenital CMV
3. Immunocompromised
1. Usually clinically silent..up to 8% primary infection results in mononucleosis
2. In utero infection of multiple systems
3. Transplants (solid and hematopoietic stem cell) : Pneumonitis, Esophagitis, Gastritis, Enterocolitis, Hepatitis, Retinitis, Graft-Versus-Host Disease
HIV/AIDS: Retinitis, Esophagitis, Gastritis, Enterocolitis, Peripheral neuropathy, Pneumonitis, Hepatitis.
What is going on with CMV infection and pregnancy?
- Primary maternal CMV Infection (when infected for the first time during life while PREGO))
- 40% risk of transmission to fetus
- 10-15% infected infants may have clinically apparent disease (mild to severe) -> 10% develop normally and 90% develop sequelae
- 85-90% infected infants are asymptomatic --> 5-15% develop sequelae and 85-90% develop normally
Explain the clinical manifestations present in symptomatic congenital CMV.
- Petechiae 76%
- Jaundice 67%
- Neurologic abnormality 68%
-Microcephaly 53%
Epstein Barr Virus Infection:
-up to _% of the world population will be infected by adulthood
- Infection is usually ___.
- Delayed infection can result in____.
- 95%
- asymptomatic
- infectious mononucleosis (glandular fever)
Epstein Barr Virus Infection:
-B lymphotropic??
- EBV maintains latency in memory B cells for the lifetime of the host
- CD21 (gp350)) and HLA Class II (gp42)
Epstein Barr Virus Infection:
- epithelial cells??
- person to person transmission of EBV..virus is released into saliva
Epstein Barr Virus Infection:
- T cells and NK cells
- very rare.
Epstein Barr Virus Infection:
- what are the three groups that can be infected?
- B lymphocytes
- Epithelial cells
- T cells and NK cells
Clinical manifestations of Epstein Barr infection:
- Wrt B cell manifestations?
- Burkitt lymphoma -> tumour can double in size every two hours
- Hodgkin lymphoma
Clinical manifestations of Epstein Barr infection:
- Wrt Epithelial cell malignancies ??
- Nasopharygneal carcinoma
- Gastric carcinoma (10%)
Clinical manifestations of Epstein Barr infection:
- Wrt T and NK cell malignancies ??
- Extranodal NK/T cell lymphoma *** very serious and particularly necrotic
- NK leukaemia
What three ways are latent infections characterized?
1. Viral gene products that promote productive replication are not made.
2. Cells harbouring latent genome are poorly recognized by the immune system.
3. The viral genome persists intact so that productive infection can be initiated to ensure spread to new hosts.
Explain herpesvirus cellular tropism and latency of:
- Varicella Zoster Virus (VZV)
- Cytomegalovirus (CMV)
- Human Herpesvirus 6 (HHV-6)
- Human Herpes virus 7 (HHV-7)
-Epstein Barr Virus (EBV)
- Kaposi's Sarcoma-associated herpesvirus (HHV-8)
- Target cell for HSV-1/2 and VZV= mucoepithelial cell and it goes latent in neurons.
-Target cell for CMV is epithelial cell, monocytes and lymphocytes. Latency = CD34 +HSC, Monocytes and Dendritic cells
-Target cell for HHV-6 and 7 = T-lymphocytes. Latency for HHV-6= CD34 + HSC monocytes. Latency for HHV-7= T-lymphocytes.
- Target cell for EBV is B-lymphocytes and epithelial cells. Latency= B-lymphocytes.
- Target cell for HHV-8 is B-lymphocytes and epithelial cells. Latency = B-Lymphocytes.
Explain the factors involved with inducing virus reactivation in:
- Varicella Zoster Virus (VZV)
- Cytomegalovirus (CMV)
- Human Herpesvirus 6 (HHV-6)
- Human Herpes virus 7 (HHV-7)
-Epstein Barr Virus (EBV)
- Kaposi's Sarcoma-associated herpesvirus (HHV-8)
-Latency in HSV 1/2 = neuron...reactivation can occur via stress, UV and immune suppression
- Latency for VZV occurs in neuron and can be reactivated by stress, UV and immune suppression.
- Latency for CMV occurs in CD34 +HSC, Monocytes, dendritic cells and can be reactivated by cell differentiation (pro-inflammatory cytokines)
- Latency for HHV-6 occurs in CD34 + HSC, monocytes and can be reactivated by cell differentiation ( pro inflammatory cytokines).
- Latency for HHV-7 occurs in T- lymphocytes and can be reactivated by pro inflammatory cytokines
- Latency for EBV occurs in B lymphocytes and can be reactivated by cell differentiation (pro inflammatory cytokines.germinal centre reaction).
- Human Herpes virus goes latent in B lymphocytes and can be reactivated by cell differentiation
Explain the stages of herpes simplex (HSV) infection of the host.
1. primary site of infection = productive infection of epithelial cells.
- infection by retrograde transport...viral DNA in latent state
2. Secondary sites of infections and site of latent infection sensory neuron ...goes latent in the sensory ganglion
- infections by antereograde tranpost
3. Site of recurrent infection: productive infection of epithelial cells
What benefit does the herpes simplex virus get from going latent vs not?
- if it didn't go latent it would be attacked cytotoxic T cells and Natural Killer cells while they are active in the epithelial cells.
- By going latent in the sensory ganglion it is protected from the T cells and Natural Killer cells
Explain the stages of Epstein Barr Virus (EBV) infection of the host.
- virus leaves infection site in the epithelial cells and goes latent in a naive b cell.
- downregulation of gene expression occurs to stop protein expression initiating this migration into b cells (memory cells).
- the memory cell will differentiate into a plasma cell which pumps out antibodies in the presence of antigens. This differentiation will reactivate the virus.
** the plasma cell that the virus becomes reactivated in can become a target of lytic Ag specific T cell Responses and NK cell receptors
Explain the herpesviral latency products for:
- latent in dorsal root ganglion...latency transcript/protein = LAT(antisense ICP0)
- latent in trigeminal, dorsal root, geniculate, celiac and vagal ganglia...latency vIL-10, UL82-82ast.
- latent in monocytes/ macrophages/ CD34+ stem cells and the latency transcript/protein = IE region and U94
- latent in CD4+ T cells....latency transcript/protein = IE region and U94
- latent in B cells and the latency transcript/protein = EBER 1 and 2, miRNA
- latent in b cells and the latency transcript/protein = LANA
****** HOWEVER, the gammaherpesviruses are associated with cancers and their latency profiles consequently change.
Clinical manifestations of Epstein Barr infection:
- B cell malignancies
- Epithelial cell malignancies
- T and NK cell malignancies
- Burkitt lymphoma, hodgkin lymphoma
-Nasopharyngeal carcinoma, Gastric carcinoma (10%)
- Extranodal NK/T cell lumphoma, NK leukaemia
EBV is a potent transforming agent for what?
- B lymphocytes
EBV is a potent transforming agent for B lymphocytes:
- How many growth transforming proteins are there?
- nine
*above are all grouped together
EBV is a potent transforming agent for B lymphocytes:
- What do the nine growth transforming proteins do?
- they drive b lymphocytes into cycle (normally they are in blood and not cycling..now they will not stop cycling/growing)
- generates continuously proliferating lymphoblastiod cell lines.
Mechanisms of EBV induced tumourgenesis, explain it.
- EBV infection is not sufficient to induce tumours: cofactors include immunosuppression and additional cellular genetic changes
- rare accidents of persistent virus infection
- in each tumour, EBV expresses different patterns of virus gene expression which complement genetic changes within the cell to initate and maintain the tumour phenotype.
Do viruses want to cause cancer?
- no - viruses want to remain latent and cancer is an accidental byproduct in the right circumstances.
Explain the three latency phenotypes in EBV associated malignancies.
- Burkitt lymphoma (Latency 1): involves EBA1, EBERs, miRNA
- Hodgkin lymphoma, Nasopharyngeal carcinoma and T/NK cell lymphomas (Latency2): involves EBNA1, EBERs, miRNA and LAMP1, LAMP2A
- PTLD in immunocompromised patients (Latency3): involves all nine proteins
**EBNA1 tethers viral DNA to human DNA so it is not lost.


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Apparently, I'm in the mood for minimalist blogs today.
I love this design of one blog post, followed by a Table of Contents at the bottom by Manu Moreale (linked to from Eddie Hinkle's 30 and Counting microcast). And the fade in and fade out when navigating.
But clicking on a header title–that changes with each post–to reach the home page seems counter-intuitive (although, intuitively, I knew to click on it).


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Governed by a strict set of rules, the practice of naturism or nudism is purposely non-erotic and nonsexual. Pictures of really big tits. The Oasis is a gated, upscale subdivision described as a hybrid nudist community.
Thanks for your help. Pasco county nude beach. Nestled among cypress trees, the rustic retreat caters to a trailer-and-camper crowd looking to get back to nature, lie around the pool, play volleyball and lollygag in a shack called the "Butt Hutt.
At Caliente on Tuesday, a convertible Mercedes was parked under the awning at the clubhouse entrance. AANR-Florida has pledged its assistance and resources toward seeing this initiative succeed. With the summer season fully upon us and temperatures flaring especially in the Midwestthe staffers at the Movoto Real Estate HQ have been eyeballing vacation spots.
For any questions you can write TCN via their interactive Contacts webpage: Like us on Facebook. Florida Business News Can hemp weave its way into the fabric of Florida farming?
Over the years, the group lobbied for the construction of the north parking lot and for lifeguards and has worked tirelessly to educate local officials, especially newly-elected ones. Treasure Coast Naturists has a Facebook page at https: Ballot Box Summer vacation plans? Homestead exemption data and figures from the communities indicate that more than 2, full-time nudists live in the county. Bring all you need for your visit including: The north parking lot that now generates millions in parking revenue for Dade County was a dirt lot used for industrial storage.
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They buy homes, send their kids to school, buy groceries, shop in the malls, eat in the same restaurants, same banks, salons, entertainment areas, pay taxes and vote. Join Our Mailing List Email: Petition started to get Caspersen Beach designated as Clothing-Optional The well-known Suncoast Naturists, a non-landed club of nudists and naturists with members throughout Sarasota County and beyond, has kicked-off a petition drive targeted at Sarasota County Commissioner, Charles D.
By continuing on our website, you consent to our use of cookies. Naturists gather to soak up the sun and sea on this clothing-optional portion of Haulover Beach between Miami and Fort Lauderdale.
Copyright Nexstar Broadcasting, Inc. Return to top of page. The work at Caliente was being conducted a week after Pasco County officials issued a news release saying the county is on pace to rake in more tourism dollars than it has sincewhen the economic recession was at its worst. Caliente has residences, from million-dollar homes to condominiums and casitas. Proceed cautiously on creating more Hillsborough cities. Full-sized radar Current conditions day Forecast Hurricane Guide.
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Return to top of page. Pasco county nude beach. For information, call Notify me of new posts by email. Where is Pasco County? Workers prepare to install new carpet inside the clubhouse at Caliente Resort and Spa. Slammed by a storm and tormented by wildfire. Democracy depends on telling facts from fake news. Dorsey has run Caliente for eight years, so he was at the helm through the worst of the recession.
Movoto spoke with a nudist realtor to learn what there is to know about living in a nudist community. Brazzers hardcore lesbian porn. Divorce and Real Estate: Registration and a signed liability waiver are required. Under the warmth of the afternoon sun, a white-haired couple rollerblade casually down a quiet street in their gated community in Land O' Lakes.
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Development Buck Naked Pasco County's robust growth includes a healthy smattering of upscale subdivisions and resorts where nobody wears any clothes. At the same time, though, we started attracting clientele through Internet marketing and social media. Heather was guest speaker at the Feb. Visit their Facebook page.
Latest Tampa Bay Weather. To answer our questions, we turned to Jackie Youngblood. The north parking lot that now generates millions in parking revenue for Dade County was a dirt lot used for industrial storage.
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The Salmon Cannon
By Emily Tripp
Salmon are born in fresh water, travel hundreds of kilometers to the ocean for most of their adult lives, and then navigate all the way back to the exact same spot they were born to spawn. But artificial water constructions, like dams, have made their journeys difficult and sometimes deadly.
Fish ladders have been used as a successful method to help salmon and other migratory fish make their way back home without getting disoriented, injured, or killed in turbines, but now there's an even better solution: the salmon cannon.
Created by Wooshh Innovations, the salmon cannon transports fish in a soft fabric tube at speeds of five to 10 meters per second (11-22 mph). This method is gentle and keeps the fish out of water for only a few seconds.
The cannon has been tested at multiple locations in Washington state. The team manually fed fish into the tubes during some trials, and let the fish swim into it themselves in others.
The successful trials of salmon cannon come at a particularly good time, as a new study revealed that sockeye salmon that have to sprint to spawning grounds through fast-moving waters have an increased mortality rate.
When swimming through rapids or downstream dams, salmon must swim extra fast, using a behavior known as "burst swimming," which requires extra oxygen and energy and can lead to cardiac collapse or heart attacks. The researchers found that if salmon chose to bust swim for long periods, they were more likely to die on their way to their spawning grounds than fish that swam slower.
"Our work demonstrates how important it is for salmon to have easy access around obstacles in the river," lead author and University of British Columbia research biologist Nicholas Burnett explained.
Emily Tripp is the publisher and editor of MarineScienceToday.com, an online magazine about what's in, on, and around the oceans. She holds marine science and biology degrees from the University of Miami's Rosenstiel School of Marine and Atmospheric Science.


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Fresno State Bulldogs at UNLV Rebels Basketball
Thomas & Mack Center, Las Vegas, NV
Saturday, February 9 @ 12:00 AM
See Full Schedule of Events for:UNLV Rebels Basketball Fresno State Bulldogs Basketball
Sorry, no tickets found. Please call (800) 967-3287 for a ticket specialist to locate tickets for you.
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Sunflower Pie | How to make Sunflower Pie
- Prep Time
- Cook Time
- Serves
About Sunflower Pie Recipe
Healthy and delicious, kids love it a lot.
Sunflower Pie is a delicious dish which is enjoyed by the people of every age group. The recipe by Ruchi Srivastava teaches how to make Sunflower Pie step by step in detail. This makes it easy to cook Sunflower Pie in your kitchen at home. This recipe can be served to 4 people. You can find this dish at most restaurants and you can also prepare Sunflower Pie at home. This amazing and mouthwatering Sunflower Pie takes 50 minutes for the preparation and 40 minutes for cooking. The aroma of this Sunflower Pie is so tempting that makes you want to eat it. When you want to prepare something very tasty and delicious for special occasion then Sunflower Pie is a good option for you. The flavour of Sunflower Pie is palatable and you will enjoy each and every bite of this. Try this Sunflower Pie and impress your family and friends.
Ingredients to make Sunflower Pie
- Ingredients for dough:
- 1 1/2 cup maida
- 1/2 Cup butter
- 1/2 tsp salt
- Chilled cold water
- Ingredients for stuffing:
- 1 cup blanched Spanish/palak
- 1/2 cup greated paneer
- 1/2 cup greated mozzarella cheese
- 1/3 tsp black pepper powder
- salt to taste
How to make Sunflower Pie
My Tip:You can change the stuffing according to your taste In oven, bake it on the maximum temperature of oven for the same time. Check it after 25 mins.


text: Madison Babb, an eighth grade English teacher at Robert Morehead Middle School in the Dollarway School District, takes 30 students to visit Arkansas State University at Jonesboro. Students toured the campus, received information about admissions and learned about life as a college student. 'It was a wonderful day that really got our students talking about college and how they are going to get there,' Babb said. 'Our students make us proud!' Special to The Commercial


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A unique and compelling website isn't a possibility anymore. Using a poor internet site causes businesses to lose clients, and that is funds out the door. Regrettably, this appears with an alarming rate of recurrence. Many small businesses proprietors design their own websites to save cash and have even more control over the project. Regrettably, sometimes they don't truly be familiar with concepts of good web design, resulting in a website that is less than ideal. Web design, in its essence, is a type of artwork. And like art, webdesign looks to offer its visitors an experience. Web page design is meant to mix form and performance in a way that the website pleasant, navigable, interesting and functional. To do this, particular number of spoken and unspoken "rules" web designers are required to follow. Don't be that website. By experience, I could say that they are the most common web site design mistakes small business owners often produce. 1 . A lot of Going On
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Like a small business owner, you comprehend how important it is to know the people in your target market. You've in all probability spent several hours creating customer profiles and figuring out how to get consumer interest. This is much like significant in web design. The way your site looks and "feels" will naturally bring a certain sort of visitor. Some websites are quite professional, many are trendy and hip, while other people are fun and bubbly. Sometimes, a website tries to speak to too many audiences. If you try to make sure you too many types of customers, you will end up with a muddled website. Identify and profile the people in your target market and look after it. 9. Lack of Contact Info
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[27] Some makes an attempt have already been made to ban these drugs, but progress continues to be sluggish to date, as, even in These jurisdictions that have guidelines focusing on designer prescription drugs, the legislation are drafted to ban analogs of illegal medications of abuse, as an alternative to analogs of prescription medicines. On the other hand, at least a person court case has resulted in a product remaining taken off the market.[28]
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In America, Pfizer acquired two patents for sildenafil: a single for its indication to deal with cardiovascular disease (promoted as Revatio) and An additional for its indicator to treat erectile dysfunction (promoted as Viagra). The compound is identical beneath equally trade names.[71]
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text:
Twitter erupted a few days ago after founder and senior pastor of Daystar Christian Centre, Sam Adeyemi released a series of tweets about mental illness. One tweet in particular was responsible for the twitter storm that followed. It read thus: The root cause of mental illness is sin (Rom 6:23) ...Read More »
Home / Tag Archives: psychiatry
#ExMuslim – Update on the Young Nigerian Held in Mental Home for Renouncing Islam
Yesterday, it was reported that Mubarak Bala, a young Nigerian man, claims he is being held against his will at a mental institution because he declared he is now an atheist. Read HERE) Bala says he comes from a Muslim family in Kano, and his father is a Muslim leader. ...Read More »
#ExMuslim – Young Nigerian Claims He Was Taken to Psych Ward by Family for Being an Atheist
On Thursday 12th June 2014, Mubarak Bala, a young Nigerian man who goes by the name ExMuslim on Twitter, declared he is now an atheist, saying all religions of the world are "like a real-life maze". He followed up with another tweet that "they" wish he was wrong and also ...Read More »
THE WHOS (Ward Rounds Episode 12)
What do you feel? I'm not sure. Can you tell it? Yes, I can try. Trying is good. Yes, you say that every time I'm here. So tell me, what do you feel? I feel them every time.Read More »


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Come on !!


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Monday, Feb. 28
Boyne City Rotary Club meets at 6 p.m. Monday at Robert's Restaurant in Boyne City.
Lions Club will meet at noon Monday at Stafford's Weathervane restaurant, Charlevoix.
Northwestern Michigan Coin and Stamp Club meets 7 p.m. Monday, Feb. 28, at Big Boy in Petoskey.
Tuesday, March 1
Grief and loss daytime group meets 10 a.m. Tuesday, March 1, at Emmanuel Epsicopal Church, 1020 e. Mitchell St., Petoskey.
Duplicate Bridge Club meets at 1 p.m. Tuesday at 7196 Pleasantview Road, Harbor Springs. Everyone welcome.Singles call if you need a partner. Call first, 526-5988.
Steppin' Out for single, divorced, or widowed, meets 7 p.m. Tuesday, March 1, at Boyne City Lanes, Boyne City. Phone 582-7291.


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Views from OKC: Yikes
Welcome to Views from OKC, Thunderous Intentions' daily roundup of the best OKC Thunder stories across the web.
New to Views? Glad to have you here, and I hope you'll make this a daily destination. Well, let's get started!
Thunder cause riots in Oklahoma City
"Amid a third loss in as many games, Russell Westbrook finished with 28 points, eight assists, and five rebounds in 29 minutes of action. Overall, OKC shot just 38 percent from the field while placing Chicago at the foul line 30 times."
I really don't have much to say until later on in the column.
A FiveThirtyEight article on Russell Westbrook
"Westbrook is involved in an NBA-high seven transition plays per game. And according to an analysis run at FiveThirtyEight's request by Brittni Donaldson of SportVU, which tracks nearly everything that happens on an NBA court, there have been 413 instances1 this season where, following a turnover or a defensive rebound in the backcourt, Westbrook took at least three dribbles and covered at least 20 feet with those dribbles. For context, John Wall, the next closest player, has done that 257 times."
Want your voice heard? Join the Thunderous Intentions team!
This is crazy. Any time you do a deep dive on Russell Westbrook like this, there's a 99% chance that he comes out miles ahead of the next closest person. If these last three games have shown you anything, it's that Russ is not a human being. This roster should not be 28-22. But they are because of the incomprehensible season Russ is putting together.
Views from Twitter
Thunder twitter really meltin down right now
— ThunderousIntentions (@thunderousint) February 2, 2017
There are two types of fans.
@thunderousint this is rock bottom. The skid starts now
— Hating with Facts (@IHateYourTeams) February 2, 2017
@thunderousint Thunder twitter needs to chill out. We all knew they were going to have bad games like this, shit happens. Learn and move on.
— Albino Maori (@JohnKiwara) February 2, 2017
If you think this is rock bottom than I'm gonna ask you to walk out the door. How do you think a Pelicans fans feel? This is not rock bottom. This is what we all should have expected this season. Oklahoma City fans need to understand something: we aren't watching a championship contender anymore. This is what mediocrity feels like. Of course it's not fun, but the boys will figure it out and they'll rip off a five-game win streak soon enough. And you all will go back to praising them.
More from Thunderous Intentions
- Oklahoma City Thunder: Is it time for general manager Sam Presti to go?56m ago
- Analyzing the success of the Ersan Ilyasova-Jerami Grant trade4h ago
- Thunderous Thoughts: Zero to Nine for OKC Thunder6h ago
- Views from OKC: January is over, time to celebrate!22h ago
- OKC Thunder: The Rich List, Volume Five1 d ago


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Cornwall teenage mental health care unit gets go-ahead
Young people with mental health issues in Cornwall are to get a purpose-built facility.
NHS England has given the go-ahead for a 12-bed unit in Bodmin to open in the summer of 2019.
Previously young people have had to travel as far as Cheshire and Norwich for treatment.
The plans have been praised by the family of Cornish teenager Ben Cowburn who killed himself in an adult mental health unit in 2010.
More on this story and others from Devon and Cornwall
His father Steve said: "We're astonished that it has finally happened. This morning there were a lot of tears of relief and disbelief.
"There is a feeling that all the hard work is starting to be worth it."
'Massive impact'
Police have raised concerns about youngsters with mental health problems being held in custody because of a lack of care beds.
Deputy Chief Constable Paul Netherton, said: "Any additional funding and facilities across the South West will help reduce the burden placed on the emergency services who have to deal with those in crisis."
Mr Cowburn, whose family set up the Invictus Trust charity after Ben's death, said the new unit would have a "massive impact".
"We've supported 15 families in the last year who are travelling as far as Norwich, Kent and Cheshire," he said.
"Hopefully this new project will mean young people have a much better chance of getting re-integrated into their families and education."
Phil Confue, chief executive of Cornwall Partnership NHS Foundation Trust, said: "Children from Cornwall and the Isles of Scilly had to travel out of county for this kind of service but this new unit will enable us to deliver care much closer to home.
"The ability to regularly see family and friends while in hospital is a key element in people's recovery and especially in the case of children."


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Views: 589, Replies: 4 » Jump to the end
Apr 9, 2016 11:37 AM CST
|Patty thank you so much for adding you photo to this database entry. Awesome semp.
It really does make you think of patent leather. Just look at how shine it is.
Apr 19, 2016 9:35 AM CST
|It's a lovely semp! As are the other new intro's
Patty 🌺
Apr 19, 2016 5:54 PM CST
|I need to get Kevin to add a photo of the mature colony.
[Last edited by valleylynn - Apr 19, 2016 5:55 PM (+)]
| Quote | Post #1121327 (3)
Aug 9, 2017 9:17 PM CST
|Here's my 'PLS' in a shady location just starting to get its purple on. I planted it there to beat the heat. In Semptember I will move it to the semp garden, assuming the temperatures moderate. It seems reasonably robust and is not complaining. We all know that Kevin does not tolerate wimps, and neither should we. (But I sometimes do )
Aug 10, 2017 5:08 PM CST
|Yours is looking great Tim. I agree about the wimps.
|« Garden.org Homepage
« Back to the top
« Forums List
« Photo of Hen and chicks (Sempervivum 'Patent Leather Shoes')
« Plant Photos Forum


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Monthly Archives: June 2012
Session One
On Sunday we held our first Maternal Health Education Program (MHEP) Session! The topic focused on risk factors mothers may encounter during pregnancy, including biological, environmental, and sociocultural factors. In addition to helping with the instruction itself, Melissa and I … Continue reading
Posted in Uncategorized Leave a comment


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We offer private and group lessons in a variety of latin dance styles, including salsa, bachata, kizomba and Zumba Fitness Classes. We also partner with studios outside of Pittsburgh to offer world-class workshops and instruction from our beautiful studio space.
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by Wadsam | June 20, 2016 11:45 am
The Afghanistan Investment Support Agency (AISA) launched a new initiative called Invest in Afghanistan today in Kabul in presence of Chief Executive Abdullah Abdullah.
Invest in Afghanistan is aimed at boosting investment in Afghanistan and turning it into a land of opportunities.
Speaking on the occasion, AISA chief Mohammad Qurban Haqjo said the initiative would help generate job opportunities in the country.
"Such initiatives are important to tackle poverty and unemployment in the country. Invest in Afghanistan will help improve local and international investment in Afghanistan," said Haqjo.
He summarized the initiative as such:
Meanwhile, Dr. Abdullah Abdullah announced the national unity government's support towards the initiative and said this initiative would be promoted through the economic department of the Foreign Affairs Ministry and Afghan Embassies in foreign countries to further encourage investors to invest in Afghanistan.
"I assure you that we have made every effort to fulfill our promises for the growth of Afghan private sector. And, we will continue these efforts, " said Abdullah Abdullah.
Also present at the ceremony was Farhad Darya, Afghanistan's top singer. He urged the people and Afghan government to support the initiative. Darya is given the title of ambassador for "Investment in Afghanistan".
"Let's change Afghanistan to a land of opportunities. Let's invest in Afghanistan," said Darya.
Why invest in Afghanistan? Please click here[1] to find out.
Source URL: http://wadsam.com/afghan-business-news/new-initiative-invest-afghanistan-launched-today-343/
Copyright ©2018 Wadsam unless otherwise noted.


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Immigration Case Successes
Displaying 65 through 72 of 507
GREEN CARD APPROVED Published: Oct 26, 2012 Our client is a citizen of Belarus. She entered the United States with an exchange visitor J-1 visa. Thereafter, she applied for change of status to a B-2 visitor for pleasure, which was granted. She then applied for an extension of her B-2 status. While the application was pending, she married a United States citizen. She was employed without
GREEN CARD APPLICATION APPROVED IN LESS THAN 2 ½ MONTHS Published: Sep 6, 2012 Our client is a Canadian citizen. She is married to a United States citizen. She was lawfully admitted to the United States prior to the marriage. Her status had expired. Our client and her husband retained our firm to obtain lawful permanent resident status for her. We advised her that because she is classified as an immediate relative as the spouse of a
L-1A APPROVED IN ONE HOUR Published: Sep 4, 2012 Our client is a Canadian citizen. He and his family own Subway franchises in both the United States and Canada. It was decided to transfer him to the United States as president of one of the Subway locations. We analyzed the situation, prepared the forms and a package that contained all of the necessary documents for approval. Because our client is a
Permission to Travel Granted in 17 Days Published: Aug 21, 2012 Our client is a citizen of India. She has a pending application for lawful permanent resident status filed with USCIS. She has been accepted to attend medical school outside of the United States, requiring her immediate physical presence. We applied for Advance Parole on an expedited basis. The application was approved in only 17 days, enabling her to start
L-1A Executive Approved Despite Criminal History without a Waiver in One-Hour Published: May 14, 2012 Our client is a Canadian citizen. He is the owner of a Canadian trucking company, and is in the process of starting a U.S. trucking company to compliment his Canadian business. The U.S. business requires his hands-on presence at this time. He hired us so that he would be able to work legally in the United States. He disclosed to us that he had been
Nonimmigrant Waiver Approved in Only 44 Days Published: May 1, 2012 Our client is a Canadian citizen. He is inadmissible for life because he reentered the United States without inspection after he had been ordered deported by an Immigration Judge. He has now resided in Canada for more than ten years. He has family in the United States that he would like to visit. We were retained and prepared an Application for a
Three Trade NAFTA Management Consultant Approvals Published: Apr 19, 2012 We were retained by a large international law firm to represent three Canadian citizens who were offered management consultant positions with a large U.S. consulting firm. We reviewed each of the Applicants credentials, advised the law firm concerning the documentation necessary for the approval of the applications, prepared each applicant for inspection
Initial Fraud Determination at Border Reversed by Immigration Judge, Client Admitted to US Published: Apr 13, 2012 Our client is a Canadian citizen. He is a well qualified management consultant to the computer industry. Previously, it had been determined by the Department of Homeland Security that he was inadmissible to the United States for fraud and misrepresentation. This ground of inadmissibility constitutes a lifetime bar to United States entry. At this point we


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