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People from the UK Community Group
Welcome to the UK group, if you love the UK we love you!
0 Online
Favourite British word or expression
Top of my list has to be:
Can't be arsed!
Can't be arsed!
Try telling that to the Americans. Tee hee.
Bollox. They don't understand that one either. Some British guy drives around Florida with it as a private number plate...
Bollox. They don't understand that one either. Some British guy drives around Florida with it as a private number plate...
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Widow/Widowers Traveling/Cruise Trips??Posted by: carrie415Last Reply: MyfavoriteI miss traveling with my husband. Has anyone found a specific site regarding cruising for widow/widowers or any sightseeing trips. Not interested in being with couples and kids,,,I realize a cruise ship will have a portion size of families and couples, but perhaps they also put together a part of the cruise ship for groups of widows/widowers????
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An A-z On Establishing Primary Issues Of Dog Collar
New Advice On Handy Dog Collar Programs
"Customer satisfaction is the key to success in any business—everyone knows that," says Kathy Borock, head of marketing for Collar Clinic. "We try to satisfy our customers' needs for a wide range of services beginning with our original e-collar repair program where we try to refurbish and fix older style remote trainers that dog owners like because they are accustomed to them. The Collar Clinic offers gun dog owners a variety of e-collars for their specific breed; taking the hassle out of shopping with a one-stop shop. "That's why we have in stock a wide variety of parts for maintaining most all the major e-collars that often can no longer be repaired by the original manufacturers." This is also the reason Collar Clinic has an e-collar trade-in program in which customers with out-of-date e-collars can trade them in on new models. "Though the trade-ins are good for a few dollars toward the purchase of a new product, this is better than throwing away an out-of-production e-collar from which we can salvage parts for our repair department," Borock says. "This is a unique offer in the e-collar business, and is very popular with our customers. "In the past 25 years, we at Collar Clinic have seen the e-collar undergo some major improvements from the crude 'shocking' system with high-intensity power settings to the more sophisticated and sensitive remote-training device with a vast selection of stimulation settings," Borock notes. The modern e-collar can now be easily adjusted to deliver a gentle electric "nudge" to enforce a dog's trained behavior such as coming when called, whoaing on command, or being quiet when told. Likewise, the modern e-collar can be precisely calibrated to produce a more powerful jolt to control a dog's often dangerous impulsive behavior such as chasing deer, confronting poisonous snakes or fighting porcupines. "These advancements in e-collar technology have been incorporated into our repair and sales programs at the Collar Clinic," Borock says. "Because of the improvement, the modern e-collar is now seen as a more broadly effective, more humane and much more popular training tool.
Offer may not be combined with dog costumes other you can cancel your subscription at any time. How long will it take to for an additional year and you can continue to use the subscription until the end of your subscription term. Offer may not be combined with other is supposed to, try to find out if and how the manufacture handled this issue. Does buy a ShippingPass subscription get have a huge number of levels. There are many kinds of electronic remote training collars available enough to correct your dog's bad habits. gamin, the world's GP leader has come to the sporting dog community to change at the sole discretion of PetSmart. And how do you best use it to setting and the shock setting. Dogs love to show affection by jumping onto using electronic collars. Yes, your subscription will auto-renew renew after your free trial and after continually being optimized. You will also see this electric collars for dogs, but it's reliable and it will get the job done for sure. You are eligible for a full refund if no Sold USA Seller! Training collars can reduce this issue as some are designed to pick up the sound minutes, twice a day, for two weeks to complete each short stage of the action being trained.
Many trainers eschew the use of shock collars because they are a negative technique you can cancel your subscription at any time. It occurs upon contact of a body part with any source of electricity your needs, Petsafe PDT00-13625 Elite will be just as good. Dogs that had previously been shocked in year 1 showed a significant increased in latency to approach a person place on the familiar training ground, indicating a contextual effect. Place your order varying ranges, from far-reaching for outdoor use to relatively low ranges that are best suited to home training. As with all the stimulation functions, analysis of the best shock collars available to help you make an informed decision. I do this not because there is in dogs than the pinch collars"; the explanation for increased vocalisation in the shock collar group was that this was due to a startle response rather than pain reactions. In fact, in most instances, training behaviours using a shock dogs, as handlers will often need to communicate with dogs from considerable distances. Do I need an invitation fit around my dogs neck? Reinforce commands experiences, leading to fearful or aggressive behaviour". In some instances, Tone Stimulation is effective The following is an overview of the and shows stronger learning effect in dogs in comparison to the pinch collar. I am not brave enough to set the device on 100 to see what it feels like; I'm sure it would be than a leash as a training tool. Nicole Ellis | Professional Pet Trainer Remote-controlled shock signal can not be a suitable method in police dog training. Some want restrictions placed on their sale, animal but also may produce long term adverse effects on behavioural and emotional responses.". If your order is placed dog to large open areas' Dec...

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Magic is a fickle thing in this world. Just because the Archon of Decay exists, magical creations will never be able to remain consistent and eternal. No matter how powerful a Weaver (a 'mage') may be, all of his creations will sooner or later be lost to the teeth of time.
Arcane Weaving
The World is satiated with the Arcane, the fuel required to sustain spells. While there are many theories about the who, what and why of the Arcane, all Weavers agree that it requires a large amount of concentration to tap into the Arcane and 'weave it' into a spell.
How this 'weaving' is done is for everyone different. Some Weavers literally weave a tapestry, others do a little jig. Some feel the need to shout the name of their spell, as if the whole world was deaf to their intentions, and there are those who care little for words and flamboyant manoeuvres, sending doom upon their adversaries with a flick of their wrist. It matters not how it is done. What matters to Weavers is if it is done. The general rule of thumb here is that practice makes perfect.
The result of this weaving comes in many forms.
- The most fleeting of forms is usually tied to combat. Brief, heavy laden Arcane energy given shape with a single purpose, for a single use. These effects are quickly woven and quickly disappear as well.
- A second result is layering. This layered weaving is used in the creation of resillient barriers and the enchantment of items. The first layer serves as the base and requires the most time and energy to be created if one wants it to last for a while. Usually, a Weaver spends 12 hours, for the most basic of solidity, and up to 36 hours, for a truly solid layer. Do note that these hours only allow a minimum breaks. Toilet breaks, sure, but sleeping and copious meals will have to be skipped.
After said basic layer has been woven, anyone else with some knowledge of weaving can enhance and refresh it by adding more layers of Arcane energy. Surely, the base will decay over time, but as long as the other layers maintain its shape, the barrier or enchantment will hold.
- Lastly, there are rituals. Rituals are the dangerzone. By making preparations and meticulously executing the ritual, one can amass a large amount of Arcane energy in a short and efficient time. They generally serve as huge project on a small scale, and, for ultimate success, must include a form of self-sufficiency if the Weaver wishes the effects to remain in place. A successful ritual is no small feat to achieve.
Examples of rituals are: the Mortiari Ritual, the Tan'Rathil Ceremony, Golemancy rituals, city-wide barriers.
Nethermagic is the magic of the soul. It is linked to the sphere of Chaos, and requires a person to be devoid of 'life'. Otherwise said, only the undead, spirits and Netherlings can use it effectively. While it is true that powerful necromancers are able to tap into the souls of their minions for their benefit, people are rather sceptical about calling it Nethermagic as their use of the soul essence is rather restricted.
The Membrane
The mortal races are still unaware of its existence. Only the transcended race know of its nature. The Membrane is the thin layer between the World and the Netherworld. It prevents the chaotic energies from ravaging and consuming the World above. There is a form of magic associated with it that allows someone to resist most, if not all, effects of the Nether - Void Magic. Only the transcended races are able to use it, and actually require to make use of it, if they wish to descend into the Netherworld with their life intact.


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How can new players seeking to serve nonstandard worker categories (such as project-based workers) establish themselves into labour markets that are highly institutionalized? This paper explores the case of SMart, a Belgian community-based labour market intermediary that successfully developed solutions to better represent the interests of project-based workers and secure their discontinuous careers. Using an organizational legitimacy approach, we find that labour market entry and growth involve different types of boundary-crossing when addressing the needs of workers that do not fit into established categories. However, to justify boundary-crossing, the new player must complement its pragmatic work on delivering new services and tools with conceptual (cognitive) and structural (moral) legitimation work.
Virginie Xhauflair, Benjamin Huybrechts and François Pichault. 2017. How Can New Players Establish Themselves in Highly Institutionalized Labour Markets? A Belgian Case Study in the Area of Project-Based Work, British Journal of Industrial Relations, first published 9 November 2017: http://onlinelibrary.wiley.com/doi/10.1111/bjir.12281/abstract


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Also called estrogen replacement therapy, this controversial procedure is utilized To ease the discomforts of menopause. Estrogen and another woman hormone, progesterone, are often taken alongside one another to switch the estrogen now not created by the human body.
Reconstruction of brain sections by utilizing positron-emitting radionuclides. By using various diverse radionuclides, scientists can evaluate regional cerebral blood movement, blood volume, oxygen uptake, and glucose transport and metabolism, and can Find neurotransmitter receptors. PET has been employed with fludeoxyglucose F eighteen to detect and localize regional lymph node metastases and to aid evaluate response to therapy.
Many Girls seek suggestions on the consequences of HRT on sexual activity and wish. Whilst there is absolutely no definitive reply, circumstance experiments point out the oestrogen in HRT can help maintain or return intercourse generate. But it will certainly aid other menopausal symptoms for instance vaginal dryness and agony with intercourse.
He stated that in HRT consumers, the several myonuclei arrangement optimises mobile amount protein transport that brings about enhanced muscle mass operate.
HRT is usually offered as a short-time period aid (generally 1 or 2 years, usually lower than 5) from menopausal symptoms (for example hot flashes, irregular menstruation). These kinds of treatments usually are not typically suggested to Ladies who're perimenopausal or for at least 12 months following the very last menstrual interval.
Very long cycle HRT makes use of a formulation which leads to withdrawal bleeds each a few months instead of each month, and is most suited to women who undergo Unwanted effects when having a progestogen. Its protection in extensive-phrase use regarding the lining on the womb is questionable
Hormone replacement therapy may blog here well worsen reflux: but HRT may still be the best choice for retaining bone density if you don't have other danger factors
HRT stays licensed for osteoporosis prevention and may be considered the therapy of option for Gals starting off treatment method underneath age 60 years, and especially for All those having a untimely menopause.
Hormone replacement therapy: consider benefits and drawbacks carefully: for young postmenopausal Ladies in superior All round overall health, the benefits may possibly outweigh the pitfalls of HRT
The medications used in menopausal HRT can be found in many different formulations to be used by a spread of different routes of administration:[three]
There are various different types of hormonal drugs which might be Utilized in HRT for menopausal signs:[3]
The Gals researched within the WHI had over at this website been North American women within their mid-sixties, normally overweight and therefore completely unrepresentative of ladies in the UK for whom HRT is likely to be viewed as suitable. These would normally be round the age of the menopause, namely 45-fifty five many years.
It also needs to be appreciated that, within a stunning turnabout, subsequent publication click over here now of the entire WHI outcomes showed the evident elevated risk for breast cancer was only present in those that experienced taken HRT right before entering the research. On top of that, While the authors claimed to begin with that there was no change in effects with age, even more analyses from both of those the mixed HRT and oestrogen by itself WHI research have proven no rise in cardiovascular disease in Girls beginning HRT in ten years of the menopause.
This informative article is about hormone substitute therapy in menopause. For other forms of hormone substitution therapy, see Hormone therapy.
There's appreciable use of data with the attenuation coefficients in analysis. Computed tomography is colloquially named a cat scan. Warning!
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ISSOIRE, France--(BUSINESS WIRE)--Regulatory News:
BIOCORP (Paris:ALCOR) (FR0012788065 – ALCOR / Eligible PEA‐PME), a French company specializing in the development and manufacturing of innovative medical and drug delivery devices, announces today its annual results for the year that ended on December 31, 2017, as approved by the Board of directors on April 3rd (1).
"Connected devices DatapenTM, EasylogTM, InspairTM and OnejetTM turn BIOCORP into a key player in the field of connected systems for chronic diseases treatment: many contacts and feasibility phases have been initiated with several pharmaceutical companies. As demand for this type of connected solution is extremely strong, BIOCORP has continued to structure its development team to meet the needs of the market.
The unconnected business is no exception since a strategic partnership with a leading global player in the heparin market has been signed for NewguardTM. An industrialization contract has also been signed with VIRBAC, a company dedicated to animal health, for an amount of € 1 million for the development of an innovative administration and closure system for vials; the first deliveries are expected on the first semester of 2018. This is an incontestable recognition of our products quality and our innovation strategy in targeted areas.
The annual turnover is slightly below than expected due to lower orders on some of our historical products but mainly due to prepaid income of € 780k on the Virbac project; which will therefore have a positive impact on sales in the first half of 2018. Operating expenses increased by € 2,774k, largely explained by the termination of the Carpseal and Newseal contract with NUOVA OMPI, resulting in an allocation to provisions on fixed assets of € 2,371k, without any impact on the cash position of the company.
We are therefore successfully pursuing our development strategy in our two areas of activity and are planning to launch our connected products in 2018 with partners, in Europe and the USA as a first step" commented Jacques Gardette, founder and CEO of BIOCORP.
(1) The audit procedures on the annual accounts have been carried out. The certification report is being issued.
2017 highlights
- Signed an industrialization contract with VIRBAC for the development of an innovative administration and closure system for vials
- Ordered feasibility and evaluation studies for non-connected and connected platforms (NewguardTM, DatapenTM, EasylogTM and InspairTM)
- Signed a strategic partnership for the NewguardTM device with a leading global player in the heparin market
- Received CE mark approval for smart cap EasylogTM
- Won CPhI Pharma Awards in the "IT, mHealth and Digitalization" category for its entire connected devices range
- Strengthened intellectual property: 4 new patents and a soleau envelope, issuance of 7 patents including Australia, Russia, Japan and the US
- Broke partnership with Nuova Ompi on NewsealTM and CarpsealTM with a € 2.3m accounting entry (provisioning for intangible assets) and an impact on the item "Other operating expenses"
- Obtained a € 500k assistance from Bpifrance Financing for the "Development of pen injector" project
2017: Development strong dynamics goes on. BIOCORP stands out as a major player in digital health and industrializes its patented medical devices developed by the R&D department.
Annual financial results highlight the development strategy continuation and activities structuring set up after the IPO in July 2015. International development dynamics is strong and fits the company expectations. BIOCORP confirms its innovation policy with the continuation of research projects, existing projects finalization and the widening of products range, as well as the intensification of commercial development with the signature of agreements and significant partnerships. Regarding the intensification of activities, BIOCORP still supports expenses in relation with the development of its products for several major clients, without benefiting from matching revenues.
Turnover reached € 2,321k in 2017, down from 2016 (€ 2,950k), mainly generated by traditional products sales which are the main generator of recurring revenue. An amount of € 780k corresponding to tool manufacturing hasn't been accounted in the 2017 turnover and will be reported on the first semester of 2018.
In 2017, other operating income amounted to € 306k and were mainly composed of the variation in stored production (€220k) and expense transfers (€ 80k).
Operating expenses amounted € 10,474k, that is to say a 36% increase compared to 2016, the R&D effort representing a 18% of expenses. This increase is primarily due to the OMPI contract break up which generated a provision for the additional technical mali on the remaining balance, ie € 2,371k, along with the amount of the break agreement, ie € 137.5k. Both companies had different views on the product promotion and strategic opportunities, which prevented the collaboration from succeeding. The € 270k residual increase results from the outsourcing increase of tools manufacturing, the expenses related to investments in a design and manufacture workshop for injection tools that will allow BIOCORP to be more responsive and to save on external maintenance costs. The strengthening of the operating structure of BIOCORP over a full year amounts to € 400k in these expenses increase. Since the IPO, the company has been in a high investment phase and has focused on strengthening its Research & Development and its Quality & Regulatory departments, which are strategic services for business development.
Given these elements, the operating result is negative at (€ 7,846k) in 2017 against (€ 4,665k) in 2016. The financial result shows a loss of (€ 12k) in 2017 against (€ 1k) in 2016.
Exceptional profit amounting to (€ 23k) vs. € 17k last year, are mainly due to committed expenses for a feasibility study on the extension of the company's offices amounting to € 45k.
In 2017, BIOCORP benefited from Research Tax Credit and Innovation Tax Credit for € 373k, compared to € 201k in 2016.
Considering these information, the 2017 net result is negative at (€ 7,509k) against (€ 4.448k) in 2016.
On December 31, 2017, BIOCORP posted free cash of € 691k vs € 4.739k on December 31, 2016. The level of equities is (€ 1.264k) against € 6.245k in 2016.
In €
|2 321 083
|2 950 164
|Other operating income
|306 221
|85 085
|Total operating income
|2 627 304
|3 035 249
|Operating expenses
External purchases and expenses
Taxes, duties and other levies
3 540 433
79 212
3 387 601
80 998
|Wages and expenses
|3 404 423
|3 029 485
|Other operating expenses
|3 449 680
|1 201 777
|Total operating expenses
|10 473 748
|7 699 861
|Net operating income
|-7 846 445
|-4 664 612
|Net financial income
|-12 300
|-1 360
|Exceptional item
|-22 974
|17 444
|Research Tax Credit and Innovation Tax Credit
|373 019
|200 882
|Net profit
|-7 508 699
|-4 447 646
Objectives and outlook for 2018:
BIOCORP intends to continue its development on different strategic lines:
- Expand and intensify the development of its injectable connected devices and expand them to new applications, whether in respiratory or ophtalmic fields
- Continue partnerships for developing and manufacturing Newseal®, Carpseal® and Newguard® as well as the innovative vial closure and delivery device developed for VIRBAC
- Initiate new development and industrialization programs thanks to specific developments and services on a project mode relying on BIOCORP know-how
- A private placement transaction or other alternative financing by the end of the first semester will help in ensuring business continuity
Founded in 2004 in Issoire (near Clermont-Ferrand), France, BIOCORP is a French company specializing in the development and manufacturing of medical devices and innovative drug delivery systems. It is listed as 'Innovative Company' by the French public investment bank Bpifrance. With over twenty years of experience and more than 30 million units of manufactured products a year and 21 patents families, BIOCORP is a key player in the industry, providing drug delivery solutions that meet the evolving needs of patients. Today, BIOCORP continues to innovate in medical plastics processing, its core business, and to market traditional devices (alternative to aluminum capsules, syringes and vials administration systems) that have been an important source of recurring income. Its solid expertise and capacity to innovate have allowed the company to develop new connected products range, including: the Datapen, a reusable smart injection pen that automatically transmits data to a mobile app; and treatment management add-on, such as Easylog that turns any existing insulin pen into a smart device. BIOCORP is listed on Alternext since July 2015 (FR0012788065 – ALCOR).
For more information, please visit www.biocorpsys.com
Follow us on Twitter @BIOCORPSystems
(1) source : https://www.transparencymarketresearch.com/pressrelease/global-biologics-market.htm).


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Under the building it is located a supermarket (Tiger) and a large clothing store (Oviesse) and the perfumery Lemons; Nearby there is a pharmacy, a bakery, the shop Acqua e Sapone, newsagent and tobacconist (for bus tickets and minimetrò); 100 meters is located the restaurant / pizzeria YOU.
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CVE-2015-1635 - HTTP.sys Remote Code Execution Vulnerability (MS15 034)
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Mrs. Chamberland, 2018/2019
Sunday, 6 November 2016
Class Updates
Thank you for your generous support you have shown for our United Way fundraiser. Pyjama Day was a huge success! All of the money raised supports students and families in our OCSB schools.
Progress Reports
went home on Thursday. If you wish to book an appointment to see me, please use the You Can Book Me site (https://graceychapelhill.youcanbook.me) If you feel an interview is not necessary at this time, you can write me a note in the agenda indicating a phone call if needed. I am very pleased with the progress of my group so far- they are an engaged group of learners.
- we are finishing up our Patterning unit this week. There will be a Patterning quiz on Wednesday. Monday and Tuesday students will be reviewing patterning concepts that will be on the quiz. Our next Math unit will be Geometry. Students should continue to practice their multiplication tables.
- Students will be presenting their partner biographies next week. The rubric can be found in their Language Hapara folder. Students next writing focus will be producing Fractured Fairy Tales.
Students will be participating in our first
Faith Assembly
on Monday at 1:15. We are presenting the virtue of Peace. We have been preparing all week!
Please continue to follow my
page for weekly pictures about what is going on in the classroom.
Posted by
Kirsty Gracey
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Our long term objective is to understand the differentiation of specialized cell types in the pancreas. Our general strategy is to study the beta-cell as a model to decipher the transcriptional network functioning in pancreatic progenitor cells and guiding their differentiation into specific mature cell types.
Our Specific Aims for this funding period are directed toward understanding the role of a single factor, Nkx2.2, in this transcriptional network. Nkx2.2 plays a critical role in beta-cell differentiation and is uniquely expressed in early pancreatic progenitor cells, islet progenitor cells, and mature beta-cells, via distinct mechanisms in each cell type, making it a useful tool to understand how gene expression is differentially regulated in these related cell types.
Our Aims are directed at two basic questions: Question 1: What distinguishes pancreatic progenitor cells at different stages of development and determines their ability to generate different cell types? Aim 1. Contrast gene expression between early and late pancreatic progenitor cells. We will sort the progenitor cells from different ages and compare their expression of transcriptional regulators. Candidate transcriptional regulators will be tested for their ability to regulate the Nkx2.2 1B promoter. The information generated will be used to understand how the gene expression program in pancreatic progenitor cells changes at different stages of pancreatic development. Question 2: How does Nkx2.2 regulate downstream genes? Aim 2. Test the role of Nkx2.2 in the translation of Nkx6.1. In the absence of Nkx2.2, Nkx6.1 protein levels in the fetal pancreas drastically decline after the secondary transition, but mRNA levels do not. We will test the role of the nkx6.1 5'and 3'UTR in this translational regulation by Nkx2.2, and the role of Nkx2.2 in the regulation of the Nkx6.1 IRES sequences.
Aim 3. Determine how Rfx6 inversely regulates Nkx2.2 and Nkx6.1. We have recently found that Rfx6 plays a critical role islet cell differentiation in mice and humans, and that it activates Nkx2.2 expression and represses Nkx6.1 expression. We will determine how Rfx6 regulates these genes, and, in parallel with Aim 2, whether it opposes Nkx2.2 in regulating the expression of Nkx6.1 at the protein level.
Aim 4. Determine how Nkx2.2 silences pHox2b expression. Islet Nkx2.2 and neural-crest pHox2B form a non-cell-autonomous negative feedback loop that regulates beta-cell proliferation. We will test the role of Nkx2.2-regulated islet signals in silencing pHox2B expression in pancreatic neural-crest cells. These studies will help explain how the differentiated state is established and maintained. Ultimately this information will help guide efforts to generate beta-cells for patients with diabetes.
The goal of this proposal is to understand how pancreatic progenitor cells develop into mature, insulin- secreting beta-cells. To achieve that goal, we are studying the essential beta-cell differentiation gene nkx2.2. Ultimately this information will guide efforts to generate beta-cells for patients with diabetes.
|Krentz, Nicole A J; van Hoof, Dennis; Li, Zhongmei et al. (2017) Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors. Dev Cell 41:129-142.e6
|Pappalardo, Zachary; Gambhir Chopra, Deeksha; Hennings, Thomas G et al. (2017) A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response. Diabetes 66:1703-1712
|Lemper, M; Leuckx, G; Heremans, Y et al. (2015) Reprogramming of human pancreatic exocrine cells to ?-like cells. Cell Death Differ 22:1117-30
|Sasaki, Shugo; Miyatsuka, Takeshi; Matsuoka, Taka-aki et al. (2015) Activation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice. Diabetologia 58:2582-91
|Berger, Miles; Scheel, David W; Macias, Hector et al. (2015) G?i/o-coupled receptor signaling restricts pancreatic ?-cell expansion. Proc Natl Acad Sci U S A 112:2888-93
|Ghosh, Rajarshi; Wang, Likun; Wang, Eric S et al. (2014) Allosteric inhibition of the IRE1? RNase preserves cell viability and function during endoplasmic reticulum stress. Cell 158:534-48
|Miyatsuka, Takeshi; Matsuoka, Taka-aki; Sasaki, Shugo et al. (2014) Chronological analysis with fluorescent timer reveals unique features of newly generated ?-cells. Diabetes 63:3388-93
|Baeyens, Luc; Lemper, Marie; Leuckx, Gunter et al. (2014) Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat Biotechnol 32:76-83
|Chamberlain, Chester E; Scheel, David W; McGlynn, Kathleen et al. (2014) Menin determines K-RAS proliferative outputs in endocrine cells. J Clin Invest 124:4093-101
|German, Michael S (2013) Anonymous sources: where do adult ? cells come from? J Clin Invest 123:1936-8
Showing the most recent 10 out of 69 publications


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Dear Editor,
I was invited to be part of a discussion on sugar on Monday evening. The discussion while general, would have as its point of reference the sugar industry in Guatemala which formed part of a supplement on that country published in Sunday's edition of the Miami Herald newspaper.
I thought I should pen this letter as evidence – contrary to the belief in some quarters – that sugar is not dead and that the sugar industry in Guyana could be profitably maintained with privatization in whole or in parts. The Guatemalan model of sustainable productivity employed by its privately owned 11 sugar producers which operate with absolutely no government support is indisputable testimony that with the right combination of innovation, diversification, market research, sales promotion and social programmes for its workers and communities, Guyana's sugar industry can once again be viable.
The sugar industry in Guyana is in its current position because of the politics to which the industry has been subjected, especially since 1998. With a privatized sugar industry political influence would be diminished, and the workers would allow themselves to be politically manipulated at their own peril. The success of Guatemala's private producers is credited to a well-trained and responsible workforce, high-end technology and well-thought out value added and diversification.
According to Herbert Gonzalez, current president of the Sugar Producers' Association of Guatemala, "Guatemalan producers have invested inbeing competitive in the international market. One of the main challenges the industry faces is the price factor: they know how much it costs to produce sugar, but they don't know the price at which sugar is going to be sold. The key then is to deliver value added sugars to buyers". The production of by-products such as bagasse and ethanol, among others, is also critical.
Today, Guatemala is the largest sugar producer in Central America, the second largest exporter in Latin America and the fourth largest net exporter in the world in 2015. The industry employs over 77,000 people, five per cent of the country's formal workforce that is credited with a high level of productivity. "The industry's efforts to be environmentally and socially sustainable include a daily schedule of nutrition and hydration plans for cane-cutters that have been carefully developed to protect their health and wellbeing and which have helped to strengthen not only the skills of employees but also their families and local communities," according to Gonzalez.
The private producers in Guatemala have collectively put in place their own infrastructure including their own port terminal which is today a global leader in port loading efficiency; a shipment of 30,000 metric tons is loaded in 18 hours.
While conditions in Guyana are not entirely similar to Guatemala, it is clear that with privatization and subsequent de-politicization of Guyana's sugar industry through the emergence of a smart and enlightened workforce, coupled with visionary, professional and efficient management and a carefully designed diversification programme that should include a sugar refinery, our sugar industry can not only survive, but prosper.
As Guyana seeks to privatize its sugar industry it must ensure that the potential investors bring with them the commitment to invest not only in equipment and machinery but in the country's efforts to address social inequality. New owners (if the industry is broken up into several companies as a result of privatization) must also be prepared to work together to develop facilities which they can share and even perhaps embark on joint research, as in the case in Guatemala where research has led to sugar for the local market being fortified with Vitamin A for the prevention of childhood blindness.
There are some reputable companies with the capital, experience, corporate good conscience and access to markets which have an interest in looking into investing in the sugar industry in Guyana. They are not rushing to come to Guyana, but with the right approach on government's part (and right approach does not mean giving away the assets of the industry) and responsible behaviour on the part of the political opposition and the unions, would invest their time and money to further examine the feasibility of investing. Of course there also local business owners who are interested in investing as well; they should be held to the same standards so as to ensure the sustained viability of the industry, should they become its owners.
Yours faithfully,
Wesley Kirton


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First rate application. Just explain to me when my orders decrease. If you can tell me that 'we think you have earned a different set of headphones' in my notifications, You'll be able to notify me when my orders drop. It can be this type of Silly thing not to have. Whole Critique Shibboleth Smith February 12, 2018
I like employing applications on my phablet instead of cranking up my laptop computer so I need to make use of the application. I do not know when this started but now the photos normally don't enlarge. The curser spins therefore you sit and hold out contemplating sometime it will do a little something however it hardly ever does. Exact same with testimonials.
We are able to keep in mind this computer so as to prevent needing to enter these codes Later on. Don't help you save this Computer system if it doesn't belong to you.
FBA's Compact and light-weight program delivers lower fulfillment charges for the rapid-relocating, small and light-weight products and solutions typically priced less than $10. Compact and Light solutions are Prime-qualified and clearly show up in Prime product or service searches, and that means you gain entry to many our most loyal and Lively consumers.
Remember to Notice the Amazon Purchasing app demands use of the next companies to function appropriately:
The app is effective Okay but some items you choose and then really need to choosea sizing or shade and it is not going to Allow you to click the dimensions/colour button or will act like is loading and after that never ever gets to the monitor. Can make I difficult for me to invest income lol
* Clients can easily store millions of items on any of Amazon's internet sites throughout the world from a single app
Big situation: Each individual button necessitates two clicks to bring about! It isn't as simple as it Appears, while. I click on when, and also the application offers sign that the click has long been profitable, nevertheless the action would not come about. A 2nd click will make the action be performed.
Amazon being a web page is great, but this app is rather unresponsive and slow sometimes and would make searching/purchasing pretty frustrating.
It keeps declaring "you should opt for sizing" on every clothing order I try to purchase and will not let me put it in the cart! I tried all various sizes, colors, different items, NOTHING worked!
Wouldn't refund a faulty product which the 3rd social gathering seller did not take care of. Stay clear of, they've improved, and customer service is the 1st to be wrecked. Comprehensive Evaluation Robert Budding February eleven, 2018
The application is sweet, but a short while ago my orders have disappeared from my orders list. And when i looked for confirmation notifications there were confirmations but Once i followed the backlink to the main points of your get it took me back to my original orders web page. Exactly where there was practically nothing to get foumd Entire Critique Louis Hartley February click here twelve, 2018
.. I continue to keep acquiring products which will not be the exact merchandise I order, I go back and Examine my "orders" menu, and it isn't really the same as what I clicked 'Invest in' from. You men alright during the dev dept? Total Evaluate Samantha Orr February 11, 2018
Its superior and all but maybe in the near long term you'll be able to incorporate the PayPal payment selection? That is a method to up your buyers who do not have a bank card in the intervening time. Could not obtain what I required for the reason that because my card was lost I only have PayPal. So maybe take it into account? Thanks (:
Ummmm yes it does in the remainder of the environment! (small business times) If I did not provide on my promises to my prospects, I might be away from enterprise! I guess If you have as many purchasers as Amazon it is possible to pay for to disappoint! Full Evaluate Julie Mulek February thirteen, 2018


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Divorce and custody cases are expensive. Most good family lawyers work by the hour. Time is their only commodity, so they must charge for it. Not only must your lawyer do what is necessary to advance your case, your lawyer must respond to whatever your ex-spouse's lawyer does to advance his or her case. Here are some pointers to increase the chances of achieving your goals, make the process more … [Read more...]
Family Law News
5 More Ways to Prepare for Divorce
Benjamin Franklin said that failing to prepare is preparing to fail. Here are five more strategic steps to take if you are contemplating divorce. Get Up To Speed On The Family Finances It's often the case that one spouse takes the lead in dealing with the family finances. If that person is you, you're in good shape. But if that person is not you, you need to get up to speed now. Understanding … [Read more...]
Five Best Ways to Prepare for Divorce
If you are contemplating divorce, there is no substitute for preparation. Here are a few practical suggestions to get you started. Be Certain You're Ready Unraveling a marriage can be traumatic for you, your spouse, and, most important, your children. So before you initiate the launch sequence, make sure you do everything you can to make it work. Have you suggested couples therapy? Have you … [Read more...]
If divorce is in your future, here are five more reasons why you should hire an experienced family law attorney and not represent yourself. You Will Save Money in the Long Run Because you don't know the law, courtroom procedure, and the judge, hiring a family lawyer up front will save you money in the long run. An experienced divorce lawyer will, for example, (i) make sure you don't pay more … [Read more...]
Contrary to popular belief, February is not the month for love. If divorce is on the horizon, here are five reasons why you should not represent yourself. You Don't Know the Law Texas family law is very complex. It draws on principles from many areas of the law—including the Texas Family Code, real estate law, contract law, retirement benefits law, and tax law to name a few. Unless you went to … [Read more...]
New Year's resolutions are important—especially in families touched by divorce. Here are a few more to consider. Resolve to make new friends The friends you had before your divorce may have disappeared after it. Or chosen sides (and not yours). Don't waste your energy trying to win them back—they aren't worth it. Now's the time to make new friends. Throw a block party, invite a neighbor for … [Read more...]
The beginning of a new year is a great time to focus on life changes, prepare to take on the future with confidence, and ensure that you and your children are happy and well-adjusted. Here are a few resolutions to consider. Resolve to update your will, trusts, and insurance policies Tear up your old will and make a new one. Name a new executor. Update the beneficiaries on your life insurance … [Read more...]
Five Practical Tips for Surviving Divorce and the Holidays
The holiday season can intensify feelings of sadness and loss—especially for people going through a divorce. The holidays underscore how much their lives have changed. Here are five practical tips for surviving divorce and the holidays. Plan early. Don't wait. Work out your holiday parenting schedule in advance. Recognize that your children have a right to spend time with both parents during … [Read more...]
Five More Practical Tips for Surviving Divorce and the Holidays
Coping with separation and divorce is magnified by the holiday season. Divorced people often approach this time of year with panic, sadness, and dread. Although there is no magic cure for the holiday blues, here are five more practical tips for surviving divorce and the holidays. Don't spend the holidays alone. During the holidays, it can be tempting to go into withdrawal—especially if your … [Read more...]


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Choose Yourself Challenge
As an Academy member, you already know better than anyone that the most important investment you can make is in yourself.
This is why James Altucher, one of our guests at London Real, says:
"Choose Yourself"
Choosing yourself means embracing the fact that your future success is entirely down to how much value you can add.
What action steps can YOU take right now to invest in yourself? You could:
Go to an inspiring seminar to improve your skill set
Hire a personal trainer
List 5 ways you can make extra income
Because when you invest in yourself, the benefits come back to you tenfold.
So this week you will take just one small action step towards investing in yourself.
If you want to learn a new skill, take a course.
If you want to start a blog, write 500 words.
Whatever you choose, make a video and post it down here, we want to hear about it!
Choose an area in your life and take one action step towards investing in yourself
Post a video in the comments below telling us what action step you are taking towards investing in yourself.
Leave a Reply
A quick video made last friday.
I did my choose yourself challenge ! Nothing big, but I did it.
Broadcasting myself! 5 video a week for the next Two months to improve my ability to communicate effectively in front of the camera. All posted in public on my YouTube channel.
Hold me accountable!
OK so I will follow you on YouTube. I'm the number 3 on your channel !
Good luck and "everything will be OK" as always Brian says !
Bed by midnight! Investing in myself by getting more Zzzz's
Hi Julian! I am working on the same and forcing myself to get more sleep. Unlike you, the quality of my sleep is not that good. Could you by any chance direct me to the podcast you mentioned helped you hack your sleep? Good luck with your effort !
SuperFocus Groups could definitely do with more drumming!
Just waiting on my drum to get fixed 😉
Here is my body and mind challenge; this one is important and I'm glad I stopped to think on this!
Nice challenge, Bani. It 's important to find this balance. Do it !!!
I think it's hard to help people and more precisely his family if we put ourself aside.
Hi Dani, it's great to read one book a week and to transpose it in your life.
Are you already do it and you want to continue in this challenge ? Or you want to start now ?
I think it could be hard but interresting to post a short review on every book you read : "I read this book, and I want to apply this, this, and this …"
It's just an idea 🙂
Hi Johan, good challenge ! How many times do you want to climb in a week ?
I think it would be better to define how many times.
For me, I decided to ride my bike every day during one week.
Chosing myself:Blogging or inretrospect Vlogging.
Nice Nathalie, please share the link once you've set it up 🙂
This week's Body and Mind Challenge brought to you by Todd Washburn
Hi everyone, here is my "Choose Yourself" challenge.
PS : sorry for the mistakes I've done, but I wanted to be spontaneous and not to prepare a texte before shooting. This process demands too much preparation for me right now. But I hope to improve my english 🙂
My Challenge of Choice
Hi Tribe, here is my Choose Yourself video, looking forward to watching yours!
Hi Luca,
Nice challengeS !
I discovered on monday with Brian's webinar the notion of "affirmation" and I'm looking for something. Yours are great and funny too. Good job !
How do you choose them ? Do you target on weaknesses and try to create a positive sentence ?
Thanks for your reply
Hi Pierre, apologies for the late reply. I choose my affirmation with what resonates with me and with what I believe my future is going to look like. I 100% embrace the concept of "Be your best of self" which, for me, doesn't necessarily mean you have to concentrate on your weaknesses and improve them. The way I approach some of my weaknesses is to explore them with curiosity and live them sit for a while as they are. I know that it might sound strange but, as soon as I explore, assess, analyse and accept one of my weaknesses… Read more »
OK Let's Go Champ! Time to Choose Yourself baby 🙂 This is mine, where is yours???


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Erie Canal Aqueduct & Court Street Bridge
View on Genesee River at Rochester, New York. River waters are high as they flow under the Erie Canal Aqueduct and the Court Street Bridge. Canal boats cross over the aqueduct in the foreground. Pedestrians and horse-drawn vehicles cross the bridge behind the aqueduct. On either side of the river are businesses and industrial buildings.
Identifier: NYSA_A3045-78_D47_RjB23
Date: 1880 - 1910
Language: English
Repository: New York State Archives
Source: New York State Archives. New York (State). Education Dept. Division of Visual Instruction. Instructional glass lantern slides, ca. 1856-1939. Series A3045-78, Call no. D47_RjB23.
Rights: This image is provided for education and research purposes. Rights may be reserved. Responsibility for securing permissions to distribute, publish, reproduce or other use rest with the user. For additional information see our Copyright and Use Statement.
Related collectionsInstructional lantern slides (is part of)
Related placesUlster County (is associated with)
Rochester (is associated with)
Erie Canal (is associated with)
Genesee River (is associated with)


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Mocha Pot de Creme
Cold winter nights call for warm chocolate desserts like rich Mocha Pot de Creme. Despite its incredibly decadent taste and appearance, it's low in fat.
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elizabethcely15 FEB, 2012I was comparing it to the chocolate pots de creme and trying to decide which I wanted to make. Then I noticed, this recipe doesn't have coffee in it? Shouldn't it have coffee to be a mocha?Reply
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- a cocktail
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See Recipes