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Biological Activity
CCK1 antagonist. Suppresses CCK-induced proliferation of acinar cells. Inhibits pancreatic secretion of digestive enzymes. Active in vivo.
Technical Data
|M. Wt
|Store at -20°C
|CAS Number
|PubChem ID
|InChI Key
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
|Max Conc. mg/mL
|Max Conc. mM
Preparing Stock Solutions
The following data is based on the product molecular weight 461.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass
|1 mg
|5 mg
|10 mg
|1 mM
|2.17 mL
|10.84 mL
|21.67 mL
|5 mM
|0.43 mL
|2.17 mL
|4.33 mL
|10 mM
|0.22 mL
|1.08 mL
|2.17 mL
|50 mM
|0.04 mL
|0.22 mL
|0.43 mL
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Product Datasheets
References are publications that support the biological activity of the product.
Makovec et al (1986) New glutamic and aspartic derivatives with potent CCK-antagonistic activity. Eur. J. Med.Chem. 21 9
Kanemitsu et al (2006) Effects of the cholecystokinin A receptor antagonist loxiglumide on the proliferation and cell cycle time of pancreatic acinar cells in rats. Pancreas 32 190 PMID: 16552340
Nakano S et al (1995) Effect of the cholecystokinin receptor antagonist loxiglumide on pancreatic exocrine function in rats after acute pancreatitis. Pancreas 10 287 PMID: 7542770
If you know of a relevant reference for Loxiglumide, please let us know.
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Keywords: Loxiglumide, Loxiglumide supplier, CR, 1505, CCK1, antagonists, Cholecystokinin1, Receptors, antagonism, acute, pancreatitis, CR1505, Receptor, 3036, Tocris Bioscience
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.


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Back to Job Board
Occidental College TENURE-TRACK ASSISTANT PROFESSOR Department of Physics
The Department of Physics at Occidental College invites applications for a tenure-track position at the rank of Assistant Professor in Astrophysics, but applications in all areas and ranks will be considered. A PhD is required, as is a dedication to teaching and research at a strong undergraduate college of the liberal arts and sciences enrolling about 2000 students. The successful candidate will demonstrate a strong ability and/or interest in teaching at all levels of undergraduate physics including laboratories, will teach in the college general education program, and will conduct research involving our students. Start-up funds will be available for initiating a research program. A typical teaching load is five classes per year. The Department has five regular faculty and is supported by a departmental assistant, a laboratory coordinator, a teaching lab technician, and a machinist.
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As is the case before every new Apple event, the company has begun to erect banners and posters promoting tomorrow's festivities. Like the invitations sent out earlier this month, the designs clearly hint at Apple's more colorful (and cheaper) iPhone 5C line; there's also suggestions we'll see a fingerprint scanner inside the iPhone 5S, as indicated by the grey rings.
Tomorrow's iPhone event is shaping up to be one of Apple's biggest ever launches—maybe the biggest in the company's history. Rather than just relying on an upgraded hero model, Apple is expected to unveil a cheaper handset in a variety of colors. This would be the first time Apple has ever launched two completely different iPhones at the same time, so there are a lot of expectations heading into tomorrow.
Additionally, iOS 7 will be a popular topic of discussion, and I'd imagine we'll see Mavericks touched on briefly. We're less than 24 hours away from Apple's official event. We pretty much know what to expect by now, but perhaps Tim Cook and Co. have a few tricks left to unveil.


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From firstname.lastname@example.com Thu May 17 07:23:38 2001
Date: Wed, 16 May 2001 23:32:05 -0500 (CDT)
From: =?iso-8859-1?Q?Haiti_Progr=E8s?= <firstname.lastname@example.com>
Subject: This Week in Haiti 19:9 5/16/2001
Article: 120190
To: undisclosed-recipients:;
This Week in Haiti,
Haitian Guacimal S.A. is an orange-extract company based in the town of St. Raphal, 38 kilometers south of Cap Hatien. The company is partly owned by Rmy Cointreau, the French company which uses the orange extract to produce a fruity liqueur by the same name. Over the past few months, workers at Guacimal have been fighting for better wages and conditions. The following is an update on the situation at Guacimal as reported by the Haitian workers' movement Batay Ouvriy (Workers' Struggle) in their April 2001 bulletin. The update was translated from French and edited by Charles Arthur of the Haiti Support Group, a solidarity organization based in England.
At the beginning of October 2000, workers employed by the Haitian Guacimal company to harvest and cut oranges used in the manufacture of the famous Cointreau liqueur, registered as a union with the Haitian Ministry of Social Affairs. [The Social Affairs Ministry is charged with dealing with labor issues and regulating labor laws].
The Union of Guacimal-St. Raphal Workers sent a list of its grievances and requests for improvements in wages and working conditions to the Guacimal management, but it was returned without even an acknowledgment of delivery. The management stuck to its position of disputing the legitimacy of the union on the grounds that some members of the union's executive committee were not registered with the company.
In mid-November, the problem with the membership of the union's executive committee was resolved by the union, yet the management still refused to meet and negotiate. Furthermore, the Ministry of Social Affairs and Labor still refused to recognize the union. [According to Batay Ouvriy, the then Social Affairs Minister Mathilde Flambert is a close associate of the wife of the Guacimal owner, Nonce Zphir.]
At the end of November, the Union of Guacimal-St. Raphal Workers notified the Guacimal S.A. management of their intention to hold a work stoppage. In mid-December, the union went on strike.
The Ministry of Social Affairs, to whom notice to go on strike had
been communicated, responded with a letter that: 1) was addressed to
so-called union; 2) requested the union to enter into a
process of negotiation/conciliation; and 3) pointed out that 1995
decree had fixed the daily minimum wage at 36 gourdes [little more
than one US dollar!].
The union retorted with an immediate response to these points, stating that:
1) the negligence and incompetence of the State was at fault because
the union had registered itself with the Ministry in early October
[and reconstituted its executive committee in November] and had thus
complied with Article 232 of the Labor Code [the obligation to
register with the Ministry within six months]. Furthermore, as the law
encourages the formation of trade unions, by addressing their
legal association as a
so-called union, the Ministry only
betrayed its obvious bias; 2) the intention to begin a process of
negotiation/conciliation was precisely the reason for the strike, and
it was the management that opposed the process; 3) according to the
Labor Code, the minimum wage is supposed to be linked to the cost of
At this time, the plantation overseer, Jean-Marie St. Fleur, began to increase his travels back and forth between Cap-Hatien and St. Raphal, causing rumors to circulate among the plantation/factory guards that the oranges would be harvested come what may, and that an attack on the union members was being prepared.
At the end of December, when a guard climbed an orange tree to harvest
the fruit, the union members shouted out their disapproval. Coming
down from the tree, the guard drew his machete and attacked the group
of union members, wounding the union Secretary, Sints Estim. [A legal
proceeding is currently underway against those involved in this act,
as well as the overseer St. Fleur, who is regarded as the intellectual
author of the attack because, only that morning, he had declared that
the guards should do the orange harvesting
at any cost.
on November 21, 2000, the overseer Jean-Marie St.
Fleur had brought together eight guards (watchmen) at the plantation
and ordered them to beat and mistreat the union members if they
continued to persist with their demands. This suggested imminent
danger to the physical integrity of the unionized workers.
(extracted from the legal suit)].
The strike continued despite pressure exerted by the local representative of the Ministry of Social Affairs, and the recently elected Lavalas Family mayor of St. Raphal, Bernes Svre.
In February, the orange trees were at the point where harvesting could no longer be delayed, and the company management grew more impatient. The overseer, St. Fleur, let it be known that a negotiation meeting between the management and the union in Cap-Hatien was envisaged. The union, as a precaution, wrote to the management seeking confirmation. Nothing happened.
Then, in a gross act of interference, the Lavalas mayor, Svre,
announced that he was
exasperated by the Guacimal workers'
individual complaints at his house, and ordered the resumption of
the harvest during the last week of February - the tenth week of the
For his part, St. Fleur, announced that no union member would be allowed to take part. The announcement stirred such a spirited response from the workers that he was obliged to modify his position: at the most, the executive committee of the union and ten additional workers would be allowed to take part, but, in reprisal for the strike, all other union members were to be excluded. Despite everything, the union continued to resist this offensive until the end of the harvest, in March.
At the beginning of March, when a delegation of the British labor movement organization, War on Want, and the British GMB trade union arrived to meet with the union, the mayor intervened to show he was violently opposed to any meeting with the unionized workers. The visiting delegation and workers were obliged to find another place to hold their meeting.
At the end of March, the harvest season had come to an end with a
continuing anti-union atmosphere, without any negotiations, much less
any improvement in the working conditions. To make matters worse, the
Gaucimal management is now victimizing union members by refusing to
allocate parcels of plantation land for them to farm during the summer
off season.
[In response, the planters' association, including some union members,
occupied the Gaucimal plantation on April 27. The following is an
Urgent Action call issued May 15 by the Haiti Support Group,
which details this latest development.]
The Haiti Support Group expresses its concern at reports of anti-union measures at the Guacimal/Rmy Cointreau orange plantation at St. Raphal in northern Haiti.
According to Batay Ouvriy, the plantation overseer, Jean-Marie St. Fleur, is discriminating against members of the union, the Syndicat des Ouvriers de Guacimal-St. Raphal, in the allocation of land plots for the use of plantation workers and other local farmers.
Each year, during the
off season - approximately April to
August -- laid-off plantation workers and other local people are
allowed to grow millet and corn on small plots of plantation land
between the orange trees. Under the share-cropping system, half of any
produce grown on the land is handed over to the landowners or
managers. At the close of the harvest season last month, Jean-Marie
St. Fleur ordered the plantation watchmen to discriminate against
union members when the land parcels were distributed.
When the discrimination against union members became apparent, the
union allied itself with a recently formed planters' association
composed of local farmers who also work the plantation land in the
off season. Together the two groups protested against the
situation. However, the plantation supervisors not only ignored the
protests, but on 20 April, Martial Compre, a plantation watchman,
severely beat a child for having picked a couple of oranges. The
child's face was swollen and black and blue.
In response, the planters' association, which includes several union members, occupied the Guacimal plantation on 27 April, demanding that the watchmen and overseer back off. They have declared they will no longer share half of their harvest with the plantation supervisors as had been the custom in the past, nor will they take orders from the present overseer or watchmen. They have declared that, though they had no intention of cutting down the orange trees, the management of Guacimal S.A. would be wise to come to negotiate an agreement with them.
Here is an excerpt of their declaration:
For over 38 years, the populations of Guacimal, Kaybedjin, Boukewon and other localities have been undergoing hardship because they were the victims of the expropriation of their lands which are now a sour orange plantation. This expropriation has obliged our children to withdraw from school; they are dying of malnutrition and lack of medical services, and suffer much because this area is arid.
We lost these lands in terrible conditions: they told us the company would give us many advantages, but it never has. These lands, however, used to feed us, for we planted sugarcane, sweet potato, yucca, and so on. Now we cannot even set foot on the lands, for if we do they slap us around... Furthermore, when we consider that the laborers, who have been harvesting these oranges for so many years in terrible conditions, set up a union to claim their rights, the watchmen and overseer joined with the mayor and the then Minister of Social Affairs, Mrs. Mathilde Flambert, to thwart their efforts. As a result, the management, Nonce and Daniel Zphir, have consistently refused to meet with them.
And finally, considering that when these lands were taken from us, this was done fraudulently because we were told we would work the fields in good conditions, that the company would make roads, health centers, schools, irrigation, etc.... none of which materialized. The least they could have done was to irrigate the orange tree plantation, but no, even this wasn't done. A few of us used to work on the plantation, but we've been laid off for participating in the union.... So we declare: THAT'S ENOUGH! Our lands will not become a stick to beat us. We've created our organization that links with various other organizations, amongst them the union, in order to work the lands anew. At the same time, we are asking Guacimal to meet quickly with the union to negotiate salaries and work conditions. If they choose not to do so, we'll take other, more drastic solutions.
Though we have not yet taken over these fields, the situation is that we are tilling the land while we wait for negotiations with the union to take place. In the meantime, Guacimal S.A. can forget about having an overseer or watchmen here - we refuse to work with those individuals now. If the management chooses to meet with us, we'll then inform them of whom we will work with as overseer in our region, which means a person of the area - we won't accept people coming from elsewhere to come order us around here in Guacimal!
This letter, addressed to the various state representatives, informs of our intent. We've reached this decision in accordance with the 1987 Constitution, according to Article 293, paragraph 36-1. For the Planters' Association: Ronalt Tezine, secretary.
The legal provision referred to authorizes farmers to resume control of lands in such circumstances in which, ten years after having reached an agreement, the terms of this agreement still have not been carried out.
The Haiti Support Group urges those who share our concern for workers' rights, and for internationally recognized human rights, to write to Rmy Cointreau expressing the urgent need for the Guacimal management to negotiate a settlement with the Syndicat des Ouvriers de Guacimal St. Raphal and the planters' association.
Please write or email to:
Dominique Hriard Dubreuil
Rmy Cointreau
152, avenue des Champs-lyses,
75008 Paris FRANCE
Email: <email@example.com>
or to :
Rmy Cointreau Amerique
1350 Avenue of the Americas, 7th Floor
New York, NY 10019
Phone : (212) 399 4200
Fax : (212) 399 6909
See the Haiti Support Group web site:


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This week we feature a very new Small Business, Indigo Flamingo Bell Tent Company. As part of a small village I know Ally and David from the school run, so I was over the moon when they agreed to be featured in our spotlight series. IF Bell Tent Company is in its first year so they are working hard to make it the success they dream of, to get that ideal work life balance, which is essential to all of us but hard to achieve. So read on to find out how this idea was born.
What was your inspiration when starting your business?
The seed was planted nearly ten years ago when we got married and had teepees at our wedding. Skip forward a few years and David had the opportunity to take a sabbatical whilst I was on maternity leave having had our second daughter. Towards the end of our time off together, we made the joint decision to change things up for our family and wanted a better work life balance. We wanted to start a business that would allow us to balance things better with a young family and had seen a few ideas around bell tents on line via social media and websites that looked great. We liked the relaxed vibe of the camping/glamping/party the bell tents could offer as a hire business, having enjoyed camping and festivals together since we first got together. Our daughters are called Imogen and Francesca and we wanted to incorporate them into the theme of the business as ultimately they're the reason we're doing this! As a result, Indigo Flamingo Bell Tents was born.
What do you believe makes your business unique?
We're small but we're very adaptable and so can offer anything from one bell tent for a glamping sleepover or party in your back garden to a whole bell tent camping village to accommodate guests at a wedding or corporate event. We aim to meet a customer's needs, however crazy their idea may be. Plus we saw a niche for this type of business in Pangbourne and the surrounding areas of Berkshire and Oxfordshire (and beyond!)
Describe a typical day?
IF Bell Tents Co Ltd is still in it's infancy so at the moment we're concentrating mostly on promoting the business and getting word out there. David will contact local magazines and publications about advertising, check social media and respond to queries. You may see him pounding the streets local villages with a handful of flyers in his hand, and a pushchair in the other! I'm also obsessed with pinterest and Instagram for ideas on glamping, bell tents and anything party related, so in the evenings once the girls are in bed I'll be scrolling through social media for inspiration!
What do you enjoy most about running your own business?
There's so much to love! The flexibility and the way it fits into family life, getting to meet new people, being able to get creative and definitely getting to be outside (although not so much of that at the moment, roll on Spring!)
What do you love about our local area?
The fact that we can look out of our windows and see fields and trees but still having brilliant local amenities and access to great transport. It really is a place where you have the best of both worlds. Where we live is fabulous for kids and families, we only have to step off the doorstep to find somewhere new to explore or revisit great walks or places like Basildon Park and Beale Park. There's a lovely village atmosphere and I love that I can walk down the road and everyone says hello.
What is your background and where are you from?
We've lived together in the area now for 12 years but David is Pangbourne born and bred. He has worked in FMCG operations and logistics for most of his career before taking a sabbatical which led to us setting up IFBTC. I am a farmer's daughter from South Lincolnshire and have and continued to work in product development in the food industry. I'd love to be able to add a food offering to our business one day, watch this space!
Check out their website here IF Bell Tents


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Welcome to LNF Books!
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These four volumes contain the telecasts of Pastor Vandeman on "It Is Written" in book form. Many of the individual chapters will be recognized as being previously published in smaller booklet form. The reader will have available 98 chapters in these four volumes.
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A bird's eye view of the city, views of prominent business blocks, hotels, city and county buildings, public schools, colleges, churches, residences, etc. And a description of Oakland by the President of the Board of Trade.
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This book talks about being ready for Jesus to come and making good choices.
The author, through appeal to the Bible, to testimony of witnesses who saw Mrs. White in vision, to the inspirational example of her life, and to the indisputible effect of following her spiritual teachings, has presented here in lucid reasoning his confidence in God's great care for His work in these contemporary times.
In the 1901–1903 controversy between John Harvey Kellogg and the denomination over the work of the Battle Creek Sanitarium and the organization of the General Conference, A. T. Jones joined with Kellogg and resigned from the ministry and from membership in the church. He was outspoken as to G. C. policy and organization and the use of the Testimonies. It was in reply to some of his allegations that this paper was published in 1906.
No one will deny that we are living in a war-mad, pleasure-mad, lawless-mad world. Peace, stability, hope, that which brings genuine joy and satisfaction, have quite generally been banished from the lives of the individuals who make up the nations of the world.There is but one cure for the ills of this generation! Greed, selfishness, hatred, unrest may be expelled from our hearts. In their place may come contentment, love, certainty, and peace. Have you ever really tried Christianity? Why not?
In John Ploughman's Talks, I have written for plowmen and common people. Hence refined taste and dainty words have been discarded for strong proverbial expressions and homely phrases. I have aimed my blows at the vices of the many, and tried to inculcate those moral virtues without which men are degraded.


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On the Move: Wesley Normington
By Enza Supermodel
Published : February 07, 2007
photo by enza supermodel
Name: Wesley Normington
Age: 26
Location: Yonge Street & Davisville Avenue
Wesley Normington works as a volunteer recruitment coordinator for Youth Assisting Youth. Prior to getting involved with the non-profit organization, Normington lived and worked overseas in Japan, teaching English for a year. A job search on the Net piqued his interest in working in the non-profit sector. Seeing the success that mentorship provides for at risk youth by youth is the best part of Normington's job. Looking to volunteer? Visit www.yay.org


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Beach & Mangrove Walk
The world's largest sand island, Fraser Island is a nature-lovers dream. One of the island's most fascinating features is its ability to sustain such a wide range of wildlife and vegetation in sand. Join a local ranger on a guided walk exploring the Great Sandy Strait and Western Beach. You'll encounter marine life, local wildlife, mangrove regions and beautiful scenery along the way. The sheltered inlets and bays along the west coast are home to many mangrove communities. Mangrove trees are easily identified by their above-ground roots which help to provide oxygen to the tree. These important plants are vital to sustaining the environment for hundreds of animals including fish, crabs, birds and bats. The flora of Fraser Island is richly diverse, representing at least six major plant communities and hundreds of species. Don't forget your camera as the scenery is just beautiful! Special Notes: To make your adventure as enjoyable as possible please wear comfortable flat-soled shoes and clothing suited to the weather conditions, bring a hat, plenty of sunscreen and bottled water. .
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FI2010 Sightseeing
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8 hours
Adult: $189.99pp
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Eddie_6505 wrote:Pretty sure it's not a genuine xjr
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In each program the content develops from the use of concrete representation of numbers to exploring problems where there is less reliance on such representation. There is also a strong emphasis on mathematical language and on encouraging estimation and self-correction. Today: Dodly is setting up his own cafe. But what food should he serve? And how much of each type of food does he need? With Flynn's help he uses data to answer his questions. Flynn all the while is asking the question "will I ever get fed?".
Teaching resources for the Australian Curriculum
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Tethered to God
Rev. Laura Brewster
1 Timothy 6:17-19
Series: Defying Gravity
Today: Tethered to God
One of the greatest gravity-defying events of all time was the first non-stop airplane flight from New York to Paris. Several elite pilots tried and failed. A relatively unknown U.S. Airmail pilot, Charles
Lindbergh, finally succeeded in 1927. He succeeded because he was focused and intentional. Success in any area of life takes effort and intentionality. This is true with regard to generosity too.
Set A Goal.
45% of Americans do not give a single dollar to charitable organizations. They are so tethered to our consumer culture, that they cannot break free to follow God's leading with regard to generosity.
The first step toward breaking the hold of our consumer culture and tethering ourselves to God's leading and teaching regarding money matters is setting a goal. Do you have a goal regarding what you intend to give to God and God's work? Sometimes Christians forget that they are meant to be generous. So Paul asked Timothy to remind the Christians he mentored. Paul said, "Tell them to do good, to be rich in the good things they do, to be generous, and to share with others" (1 Timothy 6: 18 CEB).
In a related topic, Paul also taught about the attitude we should adopt regarding giving. He told the Corinthians: "Each of you must give as you have made up your mind, not reluctantly or under compulsion, for God loves a cheerful giver." (2 Corinthians 9:7) How can giving inspire joy? Because when we give to God's work, we know that we are partnering with God to make a difference. So, do you have a giving goal? And is it enough to make you feel joyful?
Make a Plan to Reach Your Goal
Once we have set some financial goals, we need to develop a budget to meet those goals. If you don't like the word budget, call it a spending plan. As you draft your plan, consider this:
- Is your giving goal your first priority? We must begin with the portion of our income that we plan to invest in the work of God's kingdom. If we do not plan this first, we will simply be offering God leftovers.
- Second, a good spending plan includes appropriate long-term savings goals for yourself and your family. This, of course, will mean something different depending on your age and circumstances.
- Finally, after giving and saving, determine a level of spending that is pleasing to God in each of area of need and want.
Being good stewards of our income and making appropriate allocations in every area of our financial world does not happen by accident. A spending plan is the vehicle that can get us there.
A Final Step to Generosity: Live Simply
A good spending plan allows us to purchase "needs" and "wants." But we would be wise to forego purchasing all of our "wants" and instead opt to live simply. Many of us buy more stuff than we need, and that excess stuff can become a burden. An intentional decision to live more simply allows us to buy only what we can afford, what actually enhances our life, and what is in alignment with our goals. Simplicity is not about denying yourself. Simplicity is about identifying what brings real joy in life and weeding out poor substitutes – like excess stuff – that fails to provide lasting satisfaction.


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Are you caring for everyone else and putting yourself and your needs last, which leaves you feeling overwhelmed, exhausted, stressed, and burnt out? What would happen if you started to care about YOURSELF and YOUR needs and actually put yourself on your own radar? It's time to say, "Me First!"
I've figured out a method that helps you to prioritize yourself without taking anything away from anyone else...actually it only adds to your life and to everyone around you, leaving you feeling calmer, happier, energized and fulfilled.
Interested in taking on the challenge? Good news — I've got you covered when you say "Yes" to putting yourself first. It all starts on October 1st!
Mel Rosenstock Certified Health Coach Creator of "Me First Method"


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A catalog of the monthly encounters between the numerous "Adventure characters". The Guardians of Zion
Crossovers Edit
January/The Nativity War: A "proto-crossover" of sorts, testing the idea of all the Adventurers meeting one another. The Nativity story is repeating on an alien world, with the five first Adventurers being analogues of the various roles from the Biblical story: Red ends a series of hijinks as the owner of the inn, Tracy and a displaced Queen as the Sheppard's and Kathy as the one wise-woman. Ranger and a team of Crusaders are the exception, as they spend the story at odds (The Crusaders were working with "King Sherod") until they realize what is going on and agree to the historic treaty between the Skyguards and Crusaders, viewing the actual nativity from afar. The story was a success and lead to an increased overlap between Adventurers, including a running Crusader subplot in Into The Void
February/Murder Most Foul: The first proper meeting between all the various Adventure series. Ranger, Tracy, Kathy and Carter (The Crusader commander of Shark Company from Into The Void) are all taken from whatever adventure they happen to be in the middle of by Red and taken to L.A, where she requests their help in solving the murder of her new friend, Annabelle. However, she turns out to only be in a meditative trance and they are instead all transported into Middle Earth (On accident) by Ranger. Temporarily trapped their, the six Adventurers become embroiled in the events of the Hobbit, spectacularly failing to be helpful in any way. They are eventually able to leave of course and a miffed Carter reports on the antics of the others to an interested William Noble (Who would occasionally come out of retirement to make guest appearances in Walker from then on)
March/M.A.P.A: Actually two separate stories connected by the Adventurer's combined attempt to create the Multiversal Adventurers Protection Association. In the first story (Told in Horizons, A Cat's Tale and Walker) the group investigates a temporal storm in a forest, only to have their consciousness switched with those of intelligent extraterrestrial dogs. They eventually find a cure of magic herbs and agree to never speak of it again. In the second (Told in the other three series), an investigation of strange radiation in an abandoned library leads to the group being sucked into a book, where they are hired by a being claiming to be J.F.K (Who boasts unnervingly accurate knowledge of both Ranger and Will) to recover a mysterious artifact that nullifies Nex energy. After escaping the pocket world, the group realize they spent the entirety of both adventures arguing with each other and decide that a official group is a bad idea. M.A.P.A has plenty of plot hooks from the second story, with the J.F.K character and "Ranger Kyrptonite" having more expansion promised in the future.
April/Blackout: A relatively low-key story, covering a mysterious loss of power on the Marvel world Kathy and Will had been working in. Kathy and Will are aiding the victims of an Earthquake when the power goes out and are forced to also deal with a HYDRA supervillain during the blackout. Tracy is shown protecting a hospital from escaped maximum prisoners, with unexpected help from Annabelle and Captain America. Ranger pushes his power to the max keeping the Earth's various reactors from going critical without the aid of his ship, and in the process discovers the Blackout is being caused by a virus that feeds on energy. Red's story has her teaming up with Doctor Strange and Scarlet Witch to create a virus to nullify the first. The final story is a prequel told from Annabelle's point of view, showing the Adventurers trapped in Equestria and escaping just in time for the power outage.
May/The Paradox War: The six Adventurers are meeting when a portal opens and future versions of them step through and die of fatal combat wounds. Ranger and Will explore a devastated world on the other side of the portal, discovering an underground bunker with records of the "Y2K event". Upon returning, the two friends, as well as Tracy and Red, are contacted by a race of aliens who hire them to travel back in time and prevent the Y2K event from setting Earth back almost a century. They fail to do so due to Ranger's hijinks and return to the present day in time to join in on Kathy's deeper examination of the portal and future world. Going through the portal again, Will becomes embroiled in a firefight with an android replica which seriously wounds him. Ranger brings him back for medical treatment, only for the others to discover that this Ranger is another android replica, downloading and sending the collected information aboard the Unfavorable Judgment to an unknown source, with the help of the Judge's unstable A.I. With the real Ranger in tow, the Adventurers confront the unknown source, which is discovered to be a highly capable and dangerous android slash supercomputer, which Kathy had defeated previously in her career with the Y2K virus. With Rangers stolen tech, it has created an army and plans on conquering all realities. Before the two groups can start battling, the android's forces disappear and Tracy realizes and explains that the Adventurers failure to stop Y2K meant Kathy's original victory remained successful, retconning the Android out of existence. However, the memories of the disastrous war between Adventurers and Androids remains, leading to Will angrily ending his friendship with Ranger and Annabelle pondering who created the Android in the first place.


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fonikdazdsbjust popped in to say this is v nice. shades of seba in those synth stabs. Artical DonNew one I'm working on atm - https://soundcloud.com/sinai_uk/vimana/s-QwjzB <3 love your tunes, this is sick, exactly my kind of d&b. i know its not finished but my only suggestion would be to add a high passed break or some hats or something in there after 32 bars or whatever to make a bit more rolling as a switch up? kind of sounds like you have put someting like that in after 32 but its just v quiet? snare is pretty (too?) loud also imo. always feel ike a cunt saying this stuff though as its quality as is
Artical DonNew one I'm working on atm - https://soundcloud.com/sinai_uk/vimana/s-QwjzB
SmokedEggsMate of mine made this recently: https://soundcloud.com/humansynthetics/superior-beings I like it. Chilled out end of the night/chewing your face off/touching god vibe. Feedback appreciated.
Smokey McPotI've got a real itch to scratch to try some music production stuff, and was considering getting something like a Maschine Mikro to mess about with.Obviously this will be disasterous because I won't immediately be perfection, but does this sound like a reasonable entry point? My last musical dalliance was learning the saxophone for a year when I was 13. I was not good.
Smokey McPotIs the entry price worth it? for less than £200 I thought it would be alright to noodle about on, and if I get into it I can make some changes, if I dont, I can sell it on quite easily. £500+ for something I'm not certain on is a bit of a leap.
DuderonomyNot sure if I've over-done it with the echo'd vocal snippets
Stamina MCThere's stuff been written (that I'll be fucked if I'm gonna go look for)


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The WE (Women Empowered) Hub
Small Ideas: $10,000
Thank you potential voters for giving us consideration!
Our proposal is to open a free-use space with a schedule of women-specific programs for all self-identified women 18+ in Kingston, Ontario: The WE (Women Empowered) Hub.
It is based on:
1. Seeking Safety (escaping violence, victim roles, independent living)
2. Managing Powerful Emotions (coping skills, healthy alternatives, processing feelings)
3. Community Kitchen and Garden (food provisions, nutrition, gardening, sharing)
4. Aboriginal Sharing Circle (connection, healing)
5. WE Care, a rotation of (a) life skills, (b) budgeting, (c) knowing your rights, and (d) self-care (including offerings such as haircuts, dental care)
6. Scheduled drop-in, including weekends/evenings (housing applications, advice, rest, food, etc.)
We want women to make this space their own. We welcome all women. All programs are open for enrollment. Women completing programs will mentor others, with volunteerism a priority. Driven by passion, experience and focus, the WE Hub offers programs specifically designed to living an integrated, independent life. It provides a safe and stable space to heal. It offers a community connection and trusted advocate.
Why this program? Well, at-risk, high-needs, vulnerable women in Kingston make up:
- 52% of homeless persons
- 29% of shelter users. Reasons for smaller percentage: staying in temporary, unsafe situations (couch-surfing); safety concerns and re-traumatization from gender-shared services
- 792/1300 justice-based clients with mental illness in 2016/17 (Addictions Mental Health Services)
- 35% of bail supervision caseload (provincial average 15-20%), John Howard Society
What do we know?
- Some similarities with men: unemployment, lower education, addictions, generational poverty
- More commonly victims of: interpersonal violence/abuse; sexual violence (human trafficking, prostitution)
- Experiences of: familial abandonment; trauma-induced mental illness (borderline personality disorder, multiple/concurrent disorders); self-injury; single parents and, commonly, experiencing child-parent separation
- Strong, two-way relationship between homelessness and criminalization – women facing homelessness at increased risk of criminal involvement and those in criminal justice system face increased probability of homelessness upon release
- Re-establishing lives after custody is challenging
- Youth and adult categories for service access vary, leading to challenges: 25+ in homelessness sector; 19+ in correctional sector; 18+ in others
- Long waitlists and mandatory referrals for service
- Police reported sexual assault and domestic violence increasing (2018)
We must be responsive to complexity and women-specific needs. Innovative healing models are comprehensive, open and without time constraints. We will work together to strengthen existing services and tighten delivery gaps.
Our efforts are always toward creating a vibrant, healthy, inclusive community for all members. When we stigmatize and isolate women in need, we further their disadvantage, lengthen recovery pathways, and foster an unhealthy community. Let's stop cycles of disadvantage TOGETHER and NOW!
Funds will be used toward:
- Reinvigorate space to match healing intentions, including some accessibility costs
- Gardening materials to expand/diversify current space
- Food allowance, recipe book, kitchen/cooking supplies
- Program supplies
- Honorariums for mentors
Elizabeth Fry Kingston:
- Is a non-profit
- Established in 1949
- Started with improving conditions, skill building and release preparations in Prison for Women
- Operates 41 rent-geared-to-income apartments for women and their children, with wrap-around community outreach
- Runs a 12-bed Community Residential Facility for provincial/federal custody releasees
- Has a 24/7 Toll-Free Assistance line; and various other on-site, referral-based pro-social groups and counselling
The Elizabeth Fry Society of Kingston
Location: Kingston
To connect with this organisation
Visit their website at:
Contact them directly at:
Visit their Facebook page at:


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SAO PAULO - Brazil faced a test of its security preparations for the World Cup on Thursday as demonstrators aghast at the cost of the event joined protests and strikes in several major cities.
Ongoing work stoppages by police and teachers and the threat of a nationwide strike by federal police also raised fears of chaos with just four weeks to go before the Cup kicks off.
A total of 10,000 people took to the streets in Belo Horizonte, Brasilia, Manaus, Porto Alegre, Rio and Sao Paulo, according to police.
In business hub Sao Paulo, about 5,000 members of the Homeless Workers' Movement (MTST) set fire to car tires and marched to the Corinthians Arena, which will host the opening match between Brazil and Croatia on June 12.
Protesters also surrounded buses full of passengers and smashed the glass of vehicles at a car dealership that is an official FIFA sponsor.
Police used teargas against the masked demonstrators, dispersing the march into small groups.
At least 20 protesters were arrested in Sao Paulo, according to police.
Local media said at least two photographers suffered minor injuries.
In both Rio and the capital Brasilia, police used pepper spray to disperse small groups as the major protests winded down.
In the northeastern city of Recife, youths earlier took advantage of a partial strike by military police to loot stores and go on the rampage. A total of 170 people were arrested there over two days.
After blocking off several streets, Sao Paulo protesters held a rally about 300 meters (yards) from the stadium as they slammed a "World Cup without the people."
Former president Luiz Inacio Lula da Silva, at the forefront of efforts to win the country's hosting rights seven years ago, criticised the "virulent" protests.
FIFA in firing line
Many protesters vented their ire against world football body FIFA, viewed by many as only concerned with its own interests.
"FIFA go home to Switzerland," "total tax exemption for FIFA and (Cup) sponsors," "Cup of disgrace" and "Hey, FIFA, pay my fare" read some of the banners.
In Rio, one masked protester surrounded by hooded black bloc radicals ostensibly burned a World Cup stickers book while marchers bore banners reading "Money for the Cup - none for salaries."
Carlos Serrano, 32, told AFP: "I love football but beyond that there are other more important problems - the right to transport, health, education." Pedro Amarildo, 50, agreed.


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Artist's description:
A new original oil painting of a cute and adorable dog in blue shirt. It has been painted in alla prima style. A treat for all dog lovers!
The image size is 6x8 in. I will send it UNFRAMED.
Materials used:
Good Friend (2016)
Oil painting by Luba Tayakin
- Oil painting on Canvas
- One of a kind artwork
- Size: 8 x 6 x 2 in (unframed) / 8 x 6 in (actual image size)
- Signed on the front
- Style: Photorealistic
- Subject: Animals and birds
This artwork is sold by Luba Tayakin from United States


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Quintessentially Weddings Atelier
O.K. so we might not be engaged, but that wouldn't stop us from attending the Quintessentially Weddings Atelier at Somerset House, home of London Fashion Week, on the 10th and 11th April .
Showcasing some of the worlds most talented designers and artisans the Atlelier is considered the world's most luxurious wedding planning event. This is created by Quintessentially Weddings, planners of the worlds finest weddings and they would love to have you at their fourth show.
The Atelier have a little black book which is loaded with all wedding related contacts. They can provide brides with insider information to the most prominent wedding experts in a cinderealla-esque setting.
One on one advice will be provided by industry guides ranging from premium designers, fancy florists, gastronomes and the all important jewellers. Have your loved up eyes lit up yet? Additionally, a series of fashion and wedding experts will provide interviews to ensure that you make the best choice for you.
Cocktails and canapés will be served throughout the whole experience – you will surely need replenished after feasting your eyes on all that is on offer! So whether your heart desires a private consultation with Chanel, an intimate tea in Quintessentially's 'vintage tea room' or an exclusive catwalk show, The Quintessentially Weddings Atelier has it all.
We might go anyway. Maybe they'll propose tomorrow?


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Frances Macaulay Forde
Irish Lourdes - Poem by Frances Macaulay Forde
Where it is said 'Our Lady appeared ' to Knock faithful,
enterprising vendors parade their wares on sidewalks.
You'll find a large range of rosary beads
hanging in silent prayer - necklaces of every hue
to match any outfit you choose - posing for photos.
1 hour processing while you worship, Extra film,
Holy Water Bottles in the shape of Mary,
small enough to send home with the postcard
or buy a granite headstone for Father, Son,
ready-carved - off the rack, just in case
for those times when you are caught unawares...
Plastic floral wreathes, colour matched, some
have see-through domes to protect or preserve,
all kinds of religious mugs, pens, cups, mouse mats...
the soul wonders as eyes boggle in Knock shops.
Many of my poems are now available as KINDLE Poetry Chapbooks on Amazon.com
http: //www.amazon.com/s/ref=ntt_athr_dp_sr_1? _encoding=UTF8&field-author=Frances%20Macaulay%20 forde&search-alias=digital-text&sort=relevancerank
Topic(s) of this poem: Ireland
Comments about Irish Lourdes by Frances Macaulay Forde
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Read poems about / on: son, father, water, home, shopping
Frances Macaulay Forde's Other Poems
Famous Poems
Still I Rise
Maya Angelou
The Road Not Taken
Robert Frost
If You Forget Me
Pablo Neruda
Langston Hughes
Annabel Lee
Edgar Allan Poe
Stopping By Woods On A Snowy Evening
Robert Frost
Rudyard Kipling
Do Not Stand At My Grave And Weep
Mary Elizabeth Frye
I Do Not Love You Except Because I Love You
Pablo Neruda
Roald Dahl


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Somerville Open Studios 2016
April 26, 2016 - Drawing, Event, Fine Art, Gallery, Graffiti, Installation, Mixed Media, Painting, Photography, Screen Printed, Sculpture
Running from April 30 – May 1 is the Somerville Open Studios. Checkout the artwork from local artists and their studios, and more. For a the Somerville Open Studios website for extensive information!