text:
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Less common
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.
This medicine may cause some people to become dizzy, drowsy, or less alert than they are normally. If any of these side effects occur, do not drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.
Dizziness, lightheadedness, or fainting may occur with this medicine, especially when you get up from a lying or sitting position suddenly. Getting up slowly may help. If the problem continues or gets worse, check with your doctor.
This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor or dentist before taking any of the above while you are using this medicine.
The patch contains aluminum, which can cause skin burns when used during certain procedures such as magnetic resonance imaging (MRI) or cardioversion. To prevent skin burns, make sure the patch is removed before having these procedures.
Heat may cause too much of the rotigotine to pass through your skin. Do not expose the patch to direct sources of heat, such as heating pads, electric blankets, heat lamps, saunas, hot tubs, heated water beds, or direct sunlight.
If you develop a skin rash or irritation from the patch, do not expose the area to direct sunlight until it heals. Direct sunlight may cause your skin to change color.
If you see snowflake-like crystals formed in the patches, do not use them and contact UCB medical information directly at 1-800-477-7877.
This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.
To use the skin patch:
Do not stop using this medicine suddenly without first asking your doctor. You will need to slowly decrease your dose before stopping it completely.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
Missed Dose
If you forget to wear or change a patch, put one on as soon as you can. If it is almost time to put on your next patch, wait until then to apply a new patch and skip the one you missed. Do not apply extra patches to make up for a missed dose.
Store the patches at room temperature in a closed container, away from heat, moisture, and direct light.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of rotigotine in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rotigotine in the elderly.
|Pregnancy Category
|All Trimesters
|Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Rotigotine is used to treat the symptoms of Parkinson's disease, sometimes called shaking palsy. It is a dopamine agonist that helps improve muscle control and reduce muscle stiffness to allow more normal movements of the body.
This medicine was available only with your doctor's prescription.
Transdermal products containing rotigotine (Neupro®) were withdrawn from the U.S. market by Schwarz Pharma on April 30, 2008.


text:
Turning the big 4-0 is a milestone in many of our lives but one Melrose woman is using it to challenge herself and achieve a personal goal.
Gillian Montgomerie is well-known in the local community as a doctor at the Waverley Medical Practice in Galashiels.
But next month she'll join her fellow Melrose Sole Sisters in the Full Moon challenge at Walk the Walk's MoonWalk event in Edinburgh.
Gillian met her fellow team members – Ana Gibson, Amanda Cross, Kerry Wright, Ruth Fairgrieve, Kirsten Fairclough, Sarah Johnstone, Jenny Morrison, Sarah Milne and Dympna Dickson – at the Melrose Primary School gates, where their wee ones go to school.
None of them have ever attempted the MoonWalk but they are cheering each other on via a What's App group they've set up.
While the initial idea was Gillian's, many more mums have come on board – and are now looking at setting up a ladies' walking group after the MoonWalk.
As a busy mum of two who works four days a week, fitting training in has been no mean feat for Gillian.
However, the team have helped egg each other on.
The 39-year-old from Melrose said: "We've all got jobs and kids so it's a struggle – especially when you're doing a 12 mile walk which can take up to four hours!
"But we're using the What's App group so that we always have someone else to walk with, after work or at the weekends.
"Other mums who aren't doing the MoonWalk have signed up to our What's App group too and are keen to get a walking group started, once the event is over.
"So there's about 20 mums in the group now!
"We all get on really well and there's so many nice walks here in Melrose, I think we will carry on after the MoonWalk."
While the Borders has beautiful country walks, the ladies are trying to stay on tarmac as much as possible – as most of the MoonWalk route is on the hard stuff!
"We've been walking on a variety of different terrain to prepare us for the city centre route," said Gillian.
The ladies are patiently waiting on their bra packs arriving so they can decorate them, to tie in with this year's jungle safari theme.
"We're also thinking about getting different animal masks to tie in with the theme," Gillian said.
Inspiration for taking part struck close to home for Gillian – her next door neighbour Jacqueline Watson did the MoonWalk last year which got Gillian thinking about the big 4-0 this year.
She said: "Jacqueline loved everything about it – other than the weather, which was horrendous – and it really inspired me.
"I'm not usually into sports but I'm turning 40 on September 21 and I wanted to do something challenging, while raising money at the same time.
"It means I can mark turning 40 by achieving a personal goal, which is a fantastic motivator.
"And while it's taking a lot of time just now, we can also see an end in sight!"
As a GP, Gillian knows only too well how prevalent cancer diagnoses are – and is delighted to be raising funds for breast cancer research.
"It's a disease which is close to all of our hearts these days," she said.
"We all know someone who has had cancer because it's becoming so common.
"I've seen young women in their late 20s and early 30s being diagnosed, with no family history, so I know it can affect people of all ages.
"The fact the breast screening van is currently in Galashiels also helps heighten awareness, which can only be a good thing."
Thanks to her family and friends' generosity, Gillian met her £200 fundraising target this week, which she was absolutely delighted with.
However, she is hoping to harness even more support in the next few weeks from colleagues and patients.
"My colleague did a Macmillan fundraiser a few weeks ago and the patients were very generous so I'm hoping they will get behind me too," she said.
Gillian's children Sam (8) and Emma (5) and husband Craig, the golf pro at The Roxburghe Hotel and Golf Course, have also been cheering her on.
She's now just looking forward to the overnight challenge on June 10.
"I'm sure it will be a great atmosphere," she added. "Even when we're tired, we'll all spur each other on."
If you would like to support Gillian, visit the website http://wtwalk.org/moonwalkscotland2017/gillian-10.
Walker and volunteer appeal
Breast cancer charity, Walk the Walk, famous for its trademark decorated bras, is urging women, men and young people to unleash their inner Tarzan by signing up for The MoonWalk Scotland 2017.
Back with a bang for the 12th year, Scotland's much loved night-time challenge is taking place on Saturday, June 10.
With a jungle safari theme, the event will see walkers snaking past some of Edinburgh's most iconic landmarks, including Edinburgh Castle, Arthur's Seat, Calton Hill and St Giles Cathedral.
From leopards, to lynx, lemurs and lions, Walk the Walk is hoping people will let their imaginations run wild as they decorate their Jungle Safari inspired bras for the event.
Open to people aged 10 and over, walkers can take on one of four challenges: New Moon (6.55 miles), Half Moon (13.1 miles), Full Moon (26.2 miles) or Over The Moon (52.4 miles).
Eighty-thousand people have taken part in The MoonWalk Scotland over the years, helping to raise more than £19.6 million. Most of the money raised from the event stays in Scotland to help improve the lives of people with cancer now. Around 4600 women and men in Scotland are diagnosed with breast cancer each year.
Nina Barough, founder and chief executive of Walk the Walk said: "The MoonWalk Scotland is a magical night when determination, inspiration touched with the extraordinary unite to raise much needed awareness about the importance of breast care and to raise money for those with cancer in Scotland."
Walk the Walk needs 1000 amazing Volunteers to help at this year's MoonWalk Scotland, which starts at Holyrood Park. To sign up as a walker or a volunteer, visit www.walkthewalk.org.

subset: commoncrawl


text:
There is one thing parents can begin to consider for their teenage children and that is their teenage children's credit. Parents can help pave the way towards a bright financial future for their teenage child. In fact credit reports are not based on age so credit reports can be generated at any age. A credit history is vital when your child reaches adulthood. Even more importantly is teaching your child how to use credit responsibly.
image source, directsignatureloans.com
How can you prepare your child's financial future? You can start by adding them as an authorized user. This means the child will have privileges with your credit card but will not be responsible for the credit card debt. This route will only teach your child about how to use a credit card, with your guidance of course. If you want your child to have a credit report and a credit score the best way to do it is to open up 2 or 3 small balance credit cards, say a balance limit of $500. You then add them as a joint user to the account. Once you add them as a joint user a credit report is automatically generated in their name. For your peace of mind you can always only allow your child to hold one credit card at a time and alternate them out to avoid any credit mishaps where your child goes buck wild on a spending spree. If you do go the joint user route understand it is risky as you are responsable for any mistakes your child makes.
If you do go this route you will need to be very clear with your minor child on how and when to use the credit card. Setting up crystal clear expectations and boundaries is a good way to start teaching your child about credit and how to use credit cards responsibly. It could be rather disastrous if you do not set these boundaries.
You will need to teach your child the basics of credit cards, such as how a revolving balance is a bad thing. The child needs to fully understand how the credit card work, what fees are involved and when these fees are triggered. Your child should be taught that credit card balances should be repaid as quickly as possible and also the concept of a billing cycle and the grace period, as teaching your child this successfully will teach them how to get an interest free loan in effect.
There are also options for your teenage child to apply for credit in their own name. One such option is retail credit cards which require little to no credit to apply for. It would ideally help if the child has been a joint account holder for 6 months or more to qualify for a retail credit card however. These accounts tend to have low credit limits from $300 to $500 but the downside of course is these cards interest rates tend to be high, so parental guidance will be necessary here.
Another option for your minor child is to have them open a credit card with the bank or credit union that they have a checking account or savings account with. It would be best for you to go with your child in person while applying for this. Another option is a secured credit card in your child's name alone. They work like regular credit cards with the exception that the credit limit is secured by a deposit withheld by the bank or credit card issuer. There are a few that allow a minimum of only $200 which will allow your child to start building their credit now.


text:
We would LOVE to know your favorite Police or Sting song....post below
Welcome to Stingchronicity's web site!
We are a Sting/Police Tribute Band in the Doylestown, Pennsylvania area... Driven To Tears, Spirits In The Material World, Every Little Thing She Does Is Magic, King Of Pain, Synchronicity, Walking In Your Footsteps... so much amazing material. Hope to see you out there.
Please kindly note: We are not impersonators. Our aim is to honor the aesthetics of The Police and Sting's iconic song magic and honor their unique place in music history all while having fun telling our own personal story...
Todd Omohundro Original Music Click Here
Latest News
Stingchronicity T-shirts now available - show your true colors - click on the Tshirt image above
Latest Track
Bandzoogle's Music feature allows you to sell your albums and tracks - and we never take a percentage of your sales. Choose from set prices, free downloads, or even give away a track in exchange for a mailing list signup!
Our Events feature allows you to post your upcoming concerts and events on your website in a calendar or list view. The Pro plan even lets you sell tickets directly through your website!


text:
The Power Neb Ultra Nebulizer by Drive Medical is a perfect addition for patients who need nebulized medicine and want a compact easy to use nebulizer. The Power Neb Ultra Nebulizer is one of the smallest and lightest nebulizers available from Drive Medical, weighing at only 3.2 pounds the unit is convenient to store and carry from room to room. The Power Neb Ultra Nebulizer has a convenient built in slot for the Neb Kit allowing the Nebulizer to be used hands free. The unit comes complete with both a reusable and disposable neb kit, is able to deliver a consistent particle size of less than 5 microns while maintaining fast and effective treatments. Be sure to consider the Power Neb Ultra Nebulizer for your medical needs and allow it to provide you the consistently exceptional results you expect from Drive Medical.Features and Benefits
Proposition 65 Warning: This product contains a chemical known to the State of California to cause cancer, birth defects, or other reproductive harm.


text:
So, I don't have a food post today. I'm working on two amazing projects for two local colleges this week, trying to win two architectural jobs for my office to design. It's tough work and it's stiff competition but boy, if we win them will I be the cock of the walk at the office for a day or two and then people can get off my friggin back about the backlog and the fact that the six month forecast doesn't look good and jobs are in construction and fuckety fuck fuck fuck we need more work.
So, I don't have a food post because I've been slaving the day away like Bob friggin Cratchet under the mean old thumb of Ebenezer Scrooge and I got home latelast night and left for work this morning whilst it was still dark. It was an odd morning; I got on the train at what apparently is the same time as all of the construction workers doing the various jobs around the City slough off to work. There I was, on the train blackberry in hand, while lunchbox toting; carhart wearing, potty mouth spurting construction workers filled the train. Now, I love an occasional flippant swear as much as the rest of the urban population, I just didn't need to hear it for seven stops, in the pre dawn hours. It took everything out of me this morning to not tell one particular man that he needed to use his "indoor voice" and if he could keep the FUCKs to a minimum before the sun rose that would be great. Now wait you say - didn't you just use the word fuck no less than three times in your opening paragraph, yes I did, but here's the difference, if you don't like it, stop reading, no one's making you read this blog, I on the other hand had to be on that train because I needed to be to work by 7:15 to practice the presentation at 7:30. So there.
I was glad to get off the train at my stop, and proceeded to walk down the nearly empty Boston streets, that were just beginning to be bathed in the rising sun when I noticed the smallest of rats, walking along the plaza at government center. He actually walked like he had somewhere to be, straight towards City Hall, I believe he actually cut me off. Maybe he was on his way to work, ruffling through trash, socializing with the other rats, completing his plan for world domination, who knows. It seems that the City is just different before the sun comes up.


text:
Date: January 9th, 2014
The Home of UFC In Las Vegas
MGM Grand and the Palms Casino play host to MMA's biggest fights
Mixed martial arts experienced a phenomenal rise in the past decade, and casinos played a major role in the sport's entry to mainstream American consciousness. Aside from training facilities, casinos serve as the second home for many mixed martial artists, where many of their career defining moments were fought. And in many ways, the bond between MMA and the casino industry would remain unbreakable in the years to come.
MMA partly owes to casinos the popularity that it achieved over the past couple of years. "The casinos are a big part of why the MMA promotions are so successful," Las Vegas' AXS-TV Fights CEO Andre Simon said. "Casinos purchase tickets for their biggest customers, which provides guaranteed revenues to fight promoters. Casino nightclubs offer fighters additional money making opportunities via appearances and post-fight parties," added Simon. It should, thus, not be surprising that major MMA events hold its cage fights in big time casinos. MGM Grand and The Palms Casino in Las Vegas are two of the most high-profile venues of the world's biggest MMA promoter – the UFC.
MGM Grand Las Vegas
The MGM Grand Las Vegas is the biggest casino that has hosted the UFC. Its recently-held 20th anniversary card, "UFC 167," featuring Georges St. Pierre and Johny Hendricks, was held at the MGM Grand Garden Arena. The main casino floor offers 171,500 square feet of unlimited blackjack, roulette and craps action. In addition, the casino hall hosts 2,500 slot machines provided by world-renowned online gaming developer and Castle Jackpot architect, International Game Technology (IGT).
The Palms Casino Resort
The Palms Casino Resort is the other major casino that played host to UFC fights in Las Vegas. The Palms' connection to the UFC can be traced back to the World Extreme Cagefighting (WEC) before the latter was absorbed by the former 3 years ago. Until 2013, when UFC President Dana White ended the league's partnership with the casino, the Ultimate Fighter Finale was played at the Palms since 2005. The establishment's 95,000-square foot casino hall boasts of tables for dice and card games, as well as 1,300 gaming machines for slots and video poker.
Source: https://www.bkk-onlineslots.com/.Read more


text:
A touching tale of the dreams and hopes of a young man abandoned at birth.
HOLLYWOOD (PRWEB) July 21, 2012
David Farland's young adult fantasy thriller Nightingale (published by East India Press) won the grand prize for the 2012 Hollywood Book Festival, placing above all other books in all genres, both fiction and nonfiction. The Hollywood book festival honors books that the judges feel "merit further attention from filmmakers, television, and multi-media communities."
Farland will be honored with his award and a cash prize in Hollywood on Saturday, July 21.
The novel, set in Utah, tells of sixteen-year-old Bron Jones, abandoned at birth and raised in foster care. Bron is kicked out of one home after another for being "too strange," until he meets a marvelous teacher who recognizes that Bron isn't even human. He's what she calls a "nightingale," a member of an ancient species left to be raised among mankind.
This news sends Bron on a quest to discover where he came from, how to use his unique abilities, and most importantly, precisely what he is. Sometimes, the truth is better left unknown.
The contest judges said, "Despite its fantastic premise, the book is a touching tale of the dreams and hopes of a young man abandoned at birth and making his way in the world."
Although new to the book shelves, Nightingale has already received fantastic reviews. One reviewer stated that Nightingale is "High School Musical falls in love with Twilight and has Harry Potter babies," a description that made Farland chuckle. "In some ways that's so right, and in others it's so wrong," he says. "It isn't quite like anything that I've read, though many reviewers are comparing it to Twilight and The Hunger Games. "
Recently, Nightingale also won the International Book Award for Best Young Adult novel of the year.
David Farland is the New York Times bestselling author of the Runelords fantasy series. He also wrote many other books in science fiction under the name Dave Wolverton.
He has worked with such major franchises as Star Wars, the Mummy, and Starcraft.
Farland has won several awards in the past, including the Philip K. Dick Memorial Special Award for Best Novel in the English Language (science fiction), and the Whitney Award for Best Novel of the Year (historical fiction).


text:
Gourmet Greatrix
Secrets from Victoria's Kitchen
Recipe Search
Recipe Index
Fish & Seafood
Breakfast & Brunch
Cakes & Cookies
Condiments & Sauces
Freezer Friendly
Main Courses
Side Dishes
Request a Recipe
Tips and Tricks
Decorative Pie Edges
Ask a Question
How To
Sauteed Duck Breast
Cleaning Clams & Mussels
Decorative Pie Edges
Vic's 2 ounces
Culinary Sites
Coming Soon!
« Basic Fish Stock
Crostini »
September 09, 2004
Cleaning Clams & Mussels
Clams and Mussels are renowned for being gritty or making people sick, but a few basic precautions and simple cleaning procedure can make these wonderful molluscs delicious. grit free and unlikely to cause illness.
When you purchase clams or mussels, make sure to immediately unwrap them at home and store them in a dry bowl in the refrigerator, so they can breathe, otherwise they may die before you cook with them.
Using a firm brush scrub the shells under running water to remove any dirt (sand and barnacles etc.)
Discard any that have shells that are chipped, broken, or damaged in any way.
The shells should be tightly closed. If there are any that have open shells, they could be dead. Give them a tap on the counter surface, if the mollusc is still alive it will close its shell. Discard any whose shells remain open.
Just before cooking, soak your the clams or mussels in fresh water for about 20 minutes. As they breathe, they filter water and expel sand. After soaking they will have less salt and sand stored inside of their shells.
Remove the mussels from the water, by lifting them out into another bowl of clean water. Do not pour the mussels and water into a colander because the sand has sunk to the bottom of the bowl and you will tip the sand back onto the shells.Pouring the mussels and water into a straining device would cause you to pour the sand back on top of the mussels. Place these mussels into another bowl full of clean cold water.
Unlike clams, mussels have a dark beard that needs to be removed and discarded. Using a dry towel, grasp the beard and give a sharp yank out and toward the hinge-end of the mussel. Note:- Remove the beard immediately before cooking, as it is possible that the mussel can tear away from the inside of it's shell, killing it.
Once the clam or mussels are cooked, discard any that have shells that remain closed.
Posted by Victoria : September 9, 2004 06:28 PM to
Fish & Seafood
How To
Email this recipe
Printer-friendly version
Post a comment
Email Address:
Remember personal info?
Email to a friend
Email this entry to:
Your email address:
Message (optional):
Want update notifications?
Newest Recipes
Food FAQ's
Sauteed Duck Breast
Swiss Meringue Buttercream
Lemon Scented Milk Chocolate Ganache
Lemon Scented White Cake
Lemon Curd
Bistro Fruit Tart
Cleaning Clams & Mussels
Recent Comments
Syndicate this site (XML)
(What does this mean?)
Powered by
Movable Type 3.2


text:
Excitement and anticipation fill the room when a woman prepares for her first date with that special guy. She wants to work out every detail to ensure it's a perfect date, but there nagging fears that eat away at her self confidence.
5 The First Kiss
If she really likes the guy, she may worry about that first kiss. Should she let him kiss her on the first date or wait until the next one? Should she wrap her arms around him or just lean in for the kiss? Should she kiss him first? Should it be a long kiss or short and sweet? She won't want to seem over anxious, but then she won't want to push him away, either. She'll definitely worry about this one.
4 How Much Does She Tell About Herself?
He's going to ask her questions and she wants him to know about her, but she worries about how much to tell him, and how much is too much. Should she tell him about her drunken uncle or that she's anemic or that her mother wears size 10 shoes? Will saying too much put him off so that he never calls again, or will saying too little give him the impression that she doesn't want him to really know her? She'll follow his lead and answer his questions, but she'll worry about how much to tell him.
3 She'll Make a Mess While Eating
When your adrenalin is pumping, the harder you try to stay in control, the more likely you are to mess up during a meal. The woman worries that she'll knock over her wine glass or dribble marinara sauce down the front of the blouse she so carefully picked out. No matter how carefully she eats, she'll worry constantly that she'll end up wearing some part of her meal.
2 She'll Say Something Stupid
When some women get nervous, they will say silly things that they regret afterward, so she worries about saying something out of line and giving the guy the wrong impression. Whether it's blurting out an opinion that she didn't really mean, making a joke that isn't called for, or judging someone she doesn't like, she worries that something will just slip out of her mouth and make her look foolish.
1 She Won't Have Anything in Common With Him
She worries that as they begin to talk and she doesn't have anything in common with him, that the date will be over quickly. If his interests are all about sports and she hates sports, she'll worry that he'll be turned off by her lack of interest. Or if she's into classical music and art and he isn't, she'll worry that they have nothing in common and the date will turn out to be a disaster.


text:
Signup for our newsletter to get notified about sales and new products.
No products in the cart.
This dress is just too cute for words! The text artwork make these dresses super cool and adorable. The hem frills are mesh, to add a princess vibe and single jersey for warmth. 100% African grown cotton. Available in Black and Purple.
There are no reviews yet.
You must be logged in to post a review.
Username or email address *
Password *
Log in
Remember me
Lost your password?
Email address *
Password *


text:
Setting up an in silico experiment is generally as simple as following three easy steps:
1) Name Your Job
2) Select Your Protein(s) and Experiment type(s)
3) Select/Upload/Draw Ligand(s)
The majority of experimental options one would normally be required to select for the Support Vector Machine (SVM) or Molecular Docking software have already been pre-optimized for you based on our considerable experience and expertise with these programs. The SVMs we use come from peer-reviewed publications and were developed specifically for the protein they are listed. The objective is to make robust in silico experimentation available for experimental scientists who are not themselves computational chemists or bioinformaticians.
The protein/experiment selection sub-menu is organized by protein group/type. Under each protein group is a list of available experiment types. Expanding any experiment-type sub-menu will provide a list of the available specific protein or protein structures available to be used for that experiment. Selecting a higher-order checkbox will automatically select all lower level experiment(s)/protein(s). You may select any number of experiments and proteins to run at any given time, subject only to the limitations of your account type.
Once you have selected your experiment and protein of interest, you must select one or more ligands. You can chose from several publicly available ligands or load/draw your own. We provide a search function, allowing you to search for a particular ligand by name from our supply of public structures. You can upload your own ligand/ligands in SDF format, or you can use the interactive drawing function to draw a ligand of your choice. An SDF file can contain multiple ligands to be tested simultaneously.
Once you have selected your experiment, protein, and ligand simply click "Create New Job", your experiment will be added to the computational queue, and you will be taken to the experiment dashboard. The progress indicator will inform you of the status of your job(s) and provides links to the results upon completion.
The progress in the area of Molecular biology has led to the generation of large amounts of data which is almost impossible to analyze and understand manually. Bioinformatics has aided in making many advances in the interpretation and usability of this data. Drug discovery and testing of experimental therapeutics is a rapidly growing avenue of structural informatics. With algorithms that predict structures, interactions and functions of biological molecules, it has become easier and far more practical to carry out initial testing and experimentation in-silico rather than going through the expensive and time consuming wet lab techniques. With our software "Althotas Virtual Laboratory", we intend to facilitate researchers in the fields of drug design and discovery to easily simulate a docking experiment, predict potential substrates and apply chemical and physical calculations on their target drug-receptor complexes. In prediction of interactions between a drug and its receptor and computation of molecular features of a structure, machine learning and pattern recognition systems are used which apply Support Vector Machines. SVM calculations have been applied in prediction of protein secondary structure, cleavage sites, computation of molecular properties and determination of gene functions in the field of bioinformatics. In the Althotas Virtual Laboratory SVM prediction is being used to identify the drug targets while docking algorithms are applied to compute how a drug or ligand will behave when present in proximity of a certain receptor. The Althotas server has a friendly GUI and simple handling. It has joined SVM prediction techniques and docking experiments on one platform, where it can calculate functions and perform experiments on multiple ligands and receptors simultaneously and with high degree of accuracy.
Step-by-step tutorial
Here we will demonstrate the functions and usage of Althotas server with an example experiment.
Once you have logged in to the Althotas server with your respective username and password your Dashboard will appear which will have the list of your previous jobs if any. For each of the enlisted jobs you can view the results, summary and/or download the results to your hard drive.
The Create new Job button will open a workspace where you will specify the job title, choose what type of calculations/experiments you want to carry out and specify the ligand for your experimentation. There are three categories of experimentations that can be performed; you can Calculate SVM predictions ,Dock Ligands and Experimental receptors and calculate different chemical and mathematical functions e.g. logP, atomic polarizability, no. of substituted benzene rings etc. In case of an SVM prediction the result will be presented as a numerical value and it will be stated whether the substrate is valid for the receptor or not, while a docking experiment will create a structural simulation of the two molecules interacting with eachother and compute the free energy required for the ligand and its receptor to interact in kcal/mols.
The Specify Ligand label allows you to either upload a file from your hard drive or user account, choose one from the list of ligands available on the Althotas server or Draw a ligand manually. Another option is to search multiple ligands in the Althotas server and then create a .sdf file with a unique name which will be saved to your account and can be accessed later from the 'Upload ligand file' option.
The Althotas virtual Laboratory can perform both SVM predictions and docking experiments with albumins, pgps and cytochrome p450s. The server is continuously expanding the list of the drug targets and adding more experiments to its virtual laboratory.
In this tutorial we will discuss an experiment of multiple SVM predictions and one docking example with an albumin molecule.
Click on the "Download ligand file", type in or paste multiple ligands in the text box and specify a name for the file or you can search each ligand separately in 'Search by name' tab and choose from the ligand list. Once you have made a ligand list and named the file it will appear under the Select from available tab.For this virtual experiment we are computing SVM predictions for p-glycoproteins, Cytochrome p450s and albumins along with docking one albumin structure to each member of our multi-ligand list simultaneously.
For this example the ligand list contains 13 drugs that are, Aciclovir, Allopurinol , Amikacin sulphate, Amphetamine
Azapropazone, Bumetanide,Busulfan, Chlorodiazepoxide, Chlorothiazide ,Decitabine, Diazepam , Diiodisalicylic acid and Dopamine.
From the experiments list box, check SVM calculations for pgp, all SVM predictions available for cytochrome p450s that are CYP1A2, CYP2A6, CYP2D6, CYP3A4, CYP2C9 and albumins. For docking check one structure from albumin which is HSA_Fusidic_Acid_2VUF in this example. therefore this virtual experiment will tell us about the ligands that bind to albumin and the geometry of their binding, it will also explain which drug can be a pgp substrate and which cytochrome p450 plays a significant role in the drug's metabolism.
After assigning a title for this job click on Create new Job button, the finished job will appear in your dashboard from where you can click on the "view results" which will open in the form of a table. Once SVM calculations and docking is done simultaneously, some columns will be illustrating the results of docking while others are specific to SVM predictions. Each row illustrates the output of docking and SVM against one receptor-ligand pair. Description of each column in the results table is given below:
Please note that the proceeding column numbers are valid only for the results of this example, for other jobs the number of result columns will depend upon the number of virtual experiments that you have computed on your data.
The first column of each row shows the structure of the ligand (i.e. Allopurinol Chlorothiazide ,Decitabine, Diazepam etc in this example)
The second column allows you to View or Save docking Geometry where you have the option of either saving the docking results in a .pdb file format or viewing the geometry of docking in a separate window. From the quick menu in the viewing window you can save the changes you make to the image, save the file as png image or open another structure from your hard drive. The select menu allows you to popout a control panel window where you can perform all the functions and edits on your structure.
The Measure menu can calculate angles, distances, torsions in the molecular structure.
In the control panel the "Select" radio button allows you to highlight the selected atoms, residues, chains, ligand etc. Similarly the append and exclude radio buttons will do their designated function. User can also change colours, width of lines and overall view of the structure by giving it shadow or fog etc. From the view controls you can dim the front or back portion of the structure to focus on one part.
The Generate tab in the control panel allows you to build ribbon structure of the molecules and then edit the width and thickness properties of helices, coils and arrows in the ribbon view.
The third column assigns a Mol id, Each ligand is given a specific molecular id which increases by one in case of experiments done with multiple ligands.
The fourth column gives the numerical value of SVM prediction i.e. 1, 0 etc while the next column explains whether the selected ligand (e.g.. aciclovir in the first row) can be a substrate for pgps, p450s or albumins or whatever the supposed receptor is. '0' in the SVM result value column means that it can not be a substrate for the selected receptor while the value of 1 or greater means that it can be a substrate. This description is true for this particular example, for other virtual experiments the column of SVM result explains the significance of SVM's numerical result.
The final column in this example before which estimations of free energy of docking starts states the similarity of the selected receptor to its ligand compound, which varies between a 0 to 1.
The last columns in the results table state the free energy of docking in kcal/mol for each of the potential bonding of the two molecules. The results are sorted from lower to higher energy values.
The results table gives you the option of sorting and filtering your data. For instance, By pressing the Simple grid button only the lowest free energy of docking is shown while all other values are filtered out. When the cursor is pointed on the heading of each column a drop down box appears from where you can sort the results in either ascending or descending order. User can also check or uncheck which result columns he wants displayed and which ones are to be omitted from the results.
In a nutshell, this virtual experiment has told us that the only possible substrate for pgp is the drug Amikacin sulphate. In cytochrome SVM experiments CYP1A2 is the only important factor in aciclovir's metabolism. allopurinol is a substrate for all cyp450s except for CYP3A4, contrarily Amikacin sulphate only binds to CYP3A4 and no other CYP. Amphetamines and dopamine can not be a substrate of CYP3A4 and CYP2C9.
In case of Azapropazone, the cyp450s that play a significant role in the drug's metabolism are CYP1A2,CYP2D6 and CYP3A4. The only possible receptor for Bumetanide is CYP3A4. while ,Busulfan, Chlorothiazide, Diiodisalicylic acid can be possible ligands for all cyp450s except CYP2D6 and CYP2C9 , Chlorodiazepoxide is a ligand for cyp450s except for CYP2A6 and CYP2C9, The targets for Decitabine can be CYP1A2 and CYP2A6 while Diazepam is a substrate for CYP1A2 and CYP3A4.
With albumin SVM predictions , the results show that binding site 1 can be pivotal in interaction between albumin and Bumetanide, Chlorothiazide and Diiodisalicylic acid, while Chlorodiazepoxide and Diazepam can be a substrate for binding site 2 of albumin.
In case of docking experiments with HSA Fusidic acid the lowest binding energy of -8.0 kcal/mol results with ligands like Diazepam and Azapropazone.
These deductions can help us in designing drugs with similar binding domains as indicated in the results of virtual experiments and provide useful information about the binding or docking reaction that is energetically favourable and therefore can be further tested by other lab techniques.


text:
BOISE, ID--(Marketwired - Aug 23, 2016) - According to Cushman & Wakefield/Commerce's 2016 Mid-Year report, Treasure Valley's office, retail and industrial markets were in extreme high demand. Each market saw a decrease in vacancy and demand was far out pacing supply for quality product. The Boise economy continued to perform well, reflecting a strong commercial real estate market.
"At mid-year, the Boise commercial real estate market is seeing strong demand for office, retail and industrial space," said Peter O'Brien, Director at the Cushman & Wakefield/Commerce Boise office. "The combination of growth by local businesses in addition to interest from out-of-state companies looking at the Treasure Valley for expansion or relocation opportunities will continue to drive activity."
With a lack of inventory in Downtown Boise, the demand for office space remained high. Product that becomes available is quickly absorbed for existing product and pre-leased for new construction. Vacancy rate decreased to 10.4 percent in Southwest Boise when The Internet Truckstop, LLC leased 15,500 square feet at the Stevens-Henager Building. Construction is set to break ground during Q3 2016 as Brighton Corporation and Ameriben both announced plans for new corporate headquarters on a new 300 acre campus off Ten Mile Road in Meridian. With the completion of City Center Plaza and the new Simplot Headquarters in Q3 2016, we anticipate continued tightening and vacancy should continue to decline for the second half of 2016. For the full report, please visit: http://www.comre.com/uploads/reports/p1aq07eh2q16k31qtp2cmvf8vfn3.pdf
For the seventh consecutive year in a row, Downtown Boise retail openings succeeded closings with 24 openings in 2015. The Village at Meridian announced the addition of 125,000 square feet of retail space over the next two years and will bring the total gross leasable area of the center to 1.3 million square feet with 565,012 square feet of that space for retail. A new tenant, West Elm, leased 13,000 square feet in Downtown Boise and four new multitenant retail buildings were completed at North Pointe Shopping Center that were occupied by Jersey Mike's, Smashburger and Chipotle. Although the overall retail openings continued to rise, the market saw a loss in big box retail occupancy due to the closure of seven stores. Owners of big box retail space may find that demising their properties to provide accommodations for multiple smaller tenants will be a necessity to lease the vacancy space. For the full report, please visit: http://www.comre.com/uploads/reports/p1aqaffhkm1ukr3egjio10vloe23.pdf
The Boise industrial market has continued to tighten in 2016. Vacancy rates decreased to 5.3 percent and set a new all-time low, absorption is on track to set a 10 year high and asking rates continued to trend upward due to the high demand and low supply of industrial property. In the second half of 2016, landlords should expect to see a general increase in activity. Nampa and Caldwell areas will continue to attract smaller tenants although several land opportunities exist for speculative or build to suit development. Interest rates are expected to rise which will likely put pressure on cap rates. The increase in rates may have some effect on the owner-user and investment sales market, but demand is expected to remain very strong. For the full report, please visit: http://www.comre.com/uploads/reports/p1aq07feqq110c1fluobq5c5pvs3.pdf
Social Media Links:
Twitter: http://twitter.com/comre_
Facebook: https://www.facebook.com/COMRE1
Blog: http://blog.comre.com/
LinkedIn: http://www.linkedin.com/company/commerce-real-estate-solutions?trk=tabs_biz_home
About Cushman & Wakefield/Commerce
Cushman & Wakefield/Commerce operates the Cushman & Wakefield business in Idaho, Nevada, Utah and Washington. As part of the Cushman & Wakefield global platform, the firm offers innovative commercial real estate solutions to occupier and investor clients, offering transaction services, capital markets services, occupier and investor services, and real estate advisory. With nearly 300 employees, 9 million sq. ft. of property management and transaction value of more than $2.8 billion, the firm is a leading commercial real estate resource in the Intermountain West region and Pacific Northwest. Learn more at www.comre.com.
About Cushman & Wakefield
Cushman & Wakefield is a leading global real estate services firm that helps clients transform the way people work, shop, and live. The firm's 43,000 employees in more than 60 countries provide deep local and global insights that create significant value for occupiers and investors around the world. Cushman & Wakefield is among the largest commercial real estate services firms with revenue of $5 billion across core services of agency leasing, asset services, capital markets, facility services (C&W Services), global occupier services, investment & asset management (DTZ Investors), project & development services, tenant representation, and valuation & advisory. To learn more, visit www.cushmanwakefield.com or follow @CushWake on Twitter.
Contact Information:
Media Contact:
Tim Rush
+1 801 208 1100


text:
Happy Autumn!
CSA this week is TODAY, Wednesday, Nov. 23rd, from 2:30pm to 7:30pm.
Did anyone make it out to the farm the other weekend? If you did, I'd love to hear about it.
Wednesday, November 23rd – Thanksgiving week pickup…at the moment, we're in the Sky Café, and the hours are 2:30pm to 7:30pm.
Thursday, December 8th – the last CSA pickup day for 2016 L - will get 2017 info to you as soon as I get it from the farm (could be any time from now to April 2017…will keep y'all posted, and you can always contact me)
CSA Weather report…real feel temps will be mid to upper 30s, sunny and breezy (you can leave stuff in your car...just not overnight because if it gets below freezing, not good)!
Keep in mind…any time you try a food you've never eaten before…
- Do some reading about what it is, and find out if there are medical contraindications if you're on medication or have health issues
- Eat a single serving size and give it 24 hours to see how your body reacts (some might be fine, a lot might not)
- When in doubt how to cook something, look to the countries that have been using it for decades/centuries, and see what they do and don't do
- Any questions, don't hesitate to ask
What happens if you don't get any CSA emails and Thursday rolls around and it's time to go to the CSA? GO ANYWAY! There have been times over the years when various things have prevented a CSA email from being sent…computers, storms, health emergencies, etc. However, the thing to do is to come to the Cinema and in all probability, your CSA share will be there (unless there's weather that's so treacherous travel would be extremely ill-advised and even then, the farm will show up and drive from Water Mill to Huntington before some CSA members would drive from Huntington…to Huntington). And if not (which I doubt…there was only one snowstorm where the farm showed up on Friday instead of Thursday because no one could drive anywhere), there would be a sign on the door saying something, or you could call me (though with Hurricane Sandy, even my land line was down because of the Verizon battery it's hooked up to….grrrrrrr…I need to get that detached so I can get phone calls during those times when the power goes out).
Parking suggestion…try parking all the way around the building in the upper parking lot where the day care center play area is. You hopefully will find a spot, and it's a short walk down the stairs to the entrance from there, and most people don't seem to think of parking up there. If you park illegally you can get a parking ticket, it does happen!
If you are going to show up at the CSA later than 7:30pm, but before the Box Office is closing for the night (can be different every week but probably be open till at least 10pm) and it's the last minute and you're running late…call the Cinema Arts Centre Box Office at 631-423-7610 xt 0 and ask them to transfer the call to the café (do NOT leave a message to be given to the CSA because there have been occasions where we didn't get the message and someone showed up to get their food and was not happy their food wasn't there) so we can pack a bag for you, put your name on it, and leave it at the Box Office. If you don't get to the Cinema before the Box Office closes, your food will NOT be there the next day. The Cinema is under no obligation to store your food, and we don't want to be the cause of bugs being attracted to our wonderful CSA food.
If you're sharing a CSA share with someone…it's possible they're not on this email list (if not email me their full name and email address…or have them do it), so check with them and then forward this if they didn't get it (and always check the junk/spam folder).
*Keep in mind that anything you read in this email (unless it's directly related to the functioning and operation of the CSA) is subjective and like they say in the 12 step world…take what you like and leave the rest!
This week's email includes…
1. We could use help if you'd like to put in some hours starting at 2:30, 3:30 or 5:30pm (we still don't have enough for an Exchange Table)
2. CSA 101 – Bring Bags!!!
3. CSA Honey for sale! Nice gift for the holidays for…anyone!
4. The List- subject to change without notice because…farming is like that
5. Event Listings…both near and far
6. What you actually got last week
7. And now for something completely different…
1. We could use help if you'd like to put in some hours starting at 2:30, 3:30 or 5:30pm (we still don't have enough for an Exchange Table)
Respond to this email or call 631-423-7610 before NOON today, call the CSA after 2pm at 631-423-7610 xt 0 and ask for the CSA in the Café, OR just stop by at 2:30pm, 3:30pm or 5:30pm and ask if we still could use some help.
If you didn't already get an email from Rene or/and suzanne talking to you about being at the CSA on the Early Shift (3:30pm to 5:30pm) or the Late Shift (5:30pm to 7:30pm) this week, you're not on the schedule for this week.
HOWEVER, you can always show up a little before 2:30pm, 3:30pm or 5:30pm and offer to help out just in case someone doesn't show up (stuff happens).
2.CSA 101…Bring Bags!
CSA basic, for this CSA anyway, is that you need to bring your own supply of bags for packing up your CSA share every week from now till December 8th!
So, my suggestion…put bags that you're setting aside for your CSA share in EVERY vehicle you own or might ride in! J Put them in the trunk, or the glove compartment, or in a bigger bag somewhere in the car, or whatever you think will work for your situation. That way, you don't even have to remember, they're just there.
The CSA is under NO obligation to provide you with bags for your food.
I also recommend a selection of canvas, paper and plastic. I bag my CSA share up in my paper (Strawberries) and plastic bags (most everything else) and put it in my bigger canvas bag so when I get home, everything's pretty much (with some exceptions…like herbs) ready to be put right into the fridge.
And if you send someone to pick up your CSA share for you, you need to tell them to…BRING BAGS!
3.CSA Honey for sale! Nice gift for the holidays for…anyone!
We're talking Honey from our farm, Green Thumb Farm.
It's not certified organic but then again…I've never understood how one could even certify Honey organic. Bees will fly 3 to 5 miles if they're not happy where they are so, how do you control where bees go?
However, the bees at Green Thumb Farm must be really happy as they have organic Flowers to pollinate, and a large assortment of organic foods to pollinate so I don't think they need, or would want, to go anywhere. They'd be making as organic a Honey as one could make (from what I've read, the only places that have enough land to have Honey be certified organic that really could be organic are Hawaii and Canada)
Place your orders and/or make payment this week (last day to place orders is Sunday, Nov. 27th), and Honey will be delivered on Thursday, December 1st and held till December 8th (if you share with someone and that's your week to pick up).
Payment can be made in cash or by check (made out to Halseys Green Thumb).
1 lb. glass jars - $20.00
½ lb. glass jars - $12.00
4.The List - subject to change without notice because…farming is like that!
November 23, 2016
Week #26
3.Sweet Potatoes
4.Turnips (mix – Golden, Japanese Red, White with Purple top)*
Total Items: 5
Herb Share – Nov 2A
Arugula AND Peppers, Hot (dried)
*trending recipe…Turnip Fries
5.Event Listings…both near and far
Thursday, November 24th
10am to 11am
iEat Green online radio show with Bhavani Jaroff
888-874-4888 (to call in during the live show with questions)
And if you miss it, you can listen in the archives.
Sunday, November 27th
12 noon
Gary Null presents…Plant Codes: unleashing nature's healing powers
Cinema Arts Centre
423 Park Ave
To purchase tickets (this may sell out)…
$10 Members/$15 General Public (includes reception)
Join Gary Null as he presents his latest documentary on the power of food, and how eating habits are destroying health and causing irreversible damage to the planet. There will be a Q & A after the film as well as a reception.
Saturday, December 3rd
10am to 4pm
Rodale Institute Open House
611 Siegfriedale Rd.
Kutztown, PA
For more info:
Come to the farm to take pix with Santa, buy organic Xmas trees/wreaths/swags in the Garden Store, and enjoy organic treats while sitting by the fire.
6.What you actually got last week (not always what was in the email the week before because farming is like that regarding occasional last minute changes)
November 17, 2016
Week #25
1.Mei Quing Choi – 1 bunch - $3.59
2.Lettuce: Loose Leaf, Red – 1 head - $3.25
3.Sweet Potatoes – 2 lbs. - $4,75
4.Radishes (winter): Black Spanish, Chinese Green*, Chinese Red, Chinese White, Misato (Watermelon) – 2 lbs. $5.00
5.Squash, Winter: Butternut – 2 - $3.25
Total Items: 5
Total Amount: $19.75
(Since we pay $18.50 per week for our CSA share, this week we got $1.25 more than we paid…SO, that means at the moment our farmer has given us $24.25 more than we paid for up to this point. That's a little over one week's CSA share FREE! Over the course of the CSA year…and over the years…we have gotten at least one, and sometimes up to two, share's worth of food that we didn't pay for…so keep reading this and see how it plays out from week to week)
7.And now for something completely different…
Food museums!
In your travels around the country and world, you might want to visit one of these…includes one in Brooklyn!


text:
Enquire to book
Research & Innovation (R&I) at University of Aberdeen are a dedicated department whose goal is to maximise the income for university research, through providing specialist knowledge and advice. As well as identifying intellectual property opportunities and exploring innovative ideas to engage with. They are the initial contact for anyone wishing to access the university's research expertise.
What makes good teams good?
The R&I Team were asked this question at the beginning of their team-building day at the Aberdeen Conference Centre. Following an internal restructure there was an opportunity for several groups to come together to break down barriers and work collaboratively as one department.
At BlueSky Experiences we work with our customers to help them identify an aim and objectives for their team events. This was a chance for everyone to meet new people, develop a common approach to removing aspects of a 'silo' culture in a fun way. There was an additional benefit of transferring the learning back to a practical approach back in the workplace.
BlueSky Approach
The day commenced with an introductory welcome from Liz Rattray, Director of R&I before launching into some thought provoking debate to identify the essential qualities of high performing teams. A short video of an F1 pit-stop team helped illustrate the Research & Innovation team's input. The importance of goals, roles, team operating processes, relationships and inter-team relationships were identified and reinforced throughout the day. We also considered how individuals & teams learn, a variety of perceptions and an introduction to personality profiling to illustrate the value of diverse characters in teams.
The remainder of the event focused on learning through randomly splitting the delegates into three groups for a serious of team exercises.
Synergy is an exercise that involves sharing information to identify unknown secret agents. A series of cards are shared randomly among the team and through communication two objectives must be identified and problems solved. Sounds easy? Remember, we are dealing with a range of personalities; some of whom will want to talk and some will want to listen. Will the extroverts ask questions to draw the introverted people into the conversation? Success can only be achieved by sharing & contributing information. Add in a dash of problem solving skills and the answers will be revealed.
Our next challenge is House of Cards. Will our delegates be skilled in negotiation? How strong are trust levels? Will the team succeed or will the exercise collapse like a house of cards?
Finally we set the challenge of Networking. Will the team see the big picture? The temptation to focus on their own goals can be overwhelming for some. How will this impact on the other's success?
After each exercise a review takes place, answering the following questions. What went well? What could be improved? What will we do differently next time? Towards the end of the event the teams are encouraged to reflect on their learning from the day and consider how this can be used back in the workplace. Through reflection and action planning individuals & teams can decide how to improve their departmental team-working climate & organisational culture.
The Research & Innovation team certainly contributed fully to their team-building event and left with plenty to consider back at University of Aberdeen.


text:
More cuts at IBM: The IT giant is preparing to lay off "a large number" of U.S. employees in its business services unit, according to the WSJ. The work of "many" of those employees will be transfered to India.
IBM is actually doing pretty well: It grew earnings in Q4, unlike many of its tech peers. The company is also considering a $6.5 billion to $8 billion bid for Sun Microsystems (JAVA), the WSJ says.
Get the latest IBM stock price here.


text:
The internet was full of more moaning sad men than usual over the weekend, as a massive chunk of downtime broke Xbox Live and crippled Microsoft's gaming service in the UK and overseas. This is why we don't want to have to deal with an always-on console.
The glitch hit Xbox Live during the critical Saturday night gaming slot, when users found themselves unable to sign in. This instantly wiped out online multiplayer games, broke media and streaming apps, rendered games with server-side storage unplayable and generally hinted at the sort of apocalyptic future that could be triggered should Microsoft push ahead with its alleged "always-on" next-gen Xbox.
Microsoft has not yet gone public with any reason for the outage, although hacking collecting Anonymous has already claimed not-responsibility, in case you were wondering. [Techradar]


text:
FasTrak drivers must have a transponder mounted to their vehicle's windshield in order to pay the lowest tolls on The Toll Roads - $1 less than the account toll rate at every tolling point. Motorcyclists should keep the transponder in a secure location.
- Clean mounting area inside of windshield and let dry.
- Remove plastic tape from back of mounting strips on transponder.
- Position transponder as illustrated above based on your mirror type.
- Press transponder firmly against glass.
For External Transponders and Commercial Trucks
An external transponder is designed to be attached to the front of your vehicle, on a flat surface. It is screw-mounted in the area on the front bumper where the license plate is normally located. The transponder is equipped with tamper-resistant mounting screws with a unique wrench for mounting.
- Remove top two screws from the license plate.
- Position transponder so that the mounting holes in the transponder correspond to the top holes in the license plate area on the front bumper of the vehicle.
- Tighten tamper-resistant screws with the provided unique wrench to secure transponder to vehicle.
- Keep the wrench in a secure place for future adjustments or removal of the transponder.
Looking for more information?
View our FAQs on FasTrak.


text:
Toggle navigation
with us
Fish Profiles
African Catfish
African Cichlids, Lake Malawi
African Cichlids, Lake Tanganyika
African Cichlids, Lake Victoria
African Cichlids, Other
Asian Cichlids
Asian Loaches/Catfish
Asian Puffers
Australian Catfish
Central American Cichlids
Characins (Tetras)
Freshwater Eels
Freshwater Gobies
Knife Fishes
Labyrinth Fish
North American Cichlids
South American Catfish
South American Cichlids
DIY Projects
Diy Airstone Projects
Diy Aquarium - Other
Diy Aquarium Chemistry
Diy Aquarium Stand Projects
Diy Aquarium Tools Projects
Diy Decoration Projects
Diy Filter Projects
Diy Fish Food Projects
Diy Lighting Projects
Diy Overflow Projects
Diy Sump Projects
Aquarium Articles
African Cichlid Articles
Aquarium Care Articles
Aquarium Hobbyist Articles
Aquariums For Kids
Aquariums Helping People
Aquatic Plants Articles
Beginner Articles
Decoration Articles
Ethical Fishkeeping
Fish Breeding Articles
Fish Diseases Articles
General Cichlid Articles
Goldfish Articles
Invertebrate Articles
Marine Fish Articles
Native Fish Articles
New World Cichlid Articles
Pond Care Articles
Saltwater Fish Tank Articles
Terrarium Articles
Tropical Fish Articles
Fish Facts
World's Smallest Fish?
Aquarium Capacity Calculator
Hexagonal Capactiy Calculator
Fish Quantity Calculator
Substrate Calculator
Heater Wattage Calculator
Freshwater Compatibility Chart
Rainbow Shark
Other Rainbow Shark Names:
Rainbow Shark, Redfin Shark
Rainbow Shark Scientific Name:
Epalzeorhynchos frenatum, Labeo frenatus
Temperature Range:
pH Range:
Hardness Range:
Species Type:
Rainbow Shark Adult Size:
6 inches (cm)
Rainbow Shark Life Expectancy:
6 years
Rainbow Shark Habitat:
Asian flood plains
Rainbow Shark Minimum Tank Size:
55 gallons
Rainbow Shark Temperament:
Territoral and aggressive, particularly against own species.
Rainbow Shark Diet & Nutrition:
Herbivorous - Does well with vegetable based flake food supplimented with fresh vegetables.
Rainbow Shark Description:
The Rainbow Shark can be kept in a large community tank if there is plenty of cover to hide in. This larger fish is too aggressive for beginners. Very closely related to the Red Tailed Black Shark. Hollows and hiding places are recommended. Only one Rainbow Shark should be kept in each tank as they are intolerant of their own species. Also try not to keep Rainbow Sharks with Red Tailed Black Shark as they will also fight.
Tank Mate Compatibility:
Other large community fish.
Rainbow Shark Breeding & Spawning:
Difficult to breed in aquariums.
Determining Rainbow Shark Sex:
Males have a black line on the anal fin.
Aquarium Region:
Middle to top of tank.
Rainbow Shark Diseases:
None specific to species
This Rainbow Shark profile has been viewed 36228 times.
Other Cyprinids Species
Amur Sucker (Sarcocheilichthys sinensis sinensis)
Bala Shark (Balantiocheilos melanopterus)
Blue HatchetFish (Chela caeruleostigmata)
Cherry Barb (Puntius titteya)
Common Goldfish (Carassius auratus auratus)
Flying Fox Fish(Epalzeorhynchos kalopterus)
Gold Danio (Brachydanio albolineatus)
Goldfish (Carassius auratus auratus)
Koi (Cyprinus carpio carpio)
Rainbow Shark (Epalzeorhynchos frenatum)
Red Tailed Black Shark (Epalzeorhynchos bicolor)
Siamese Algae Eater (Crossocheilus siamensis)
Tiger Barb (Puntius tetrazona)
Tinfoil Barb (Barbodes schwanenfeldii)
White Cloud Mountain Minnow (Tanichthys albonubes)
Zebra Danio (Danio rerio)


text:
Dear Mr. Fujisawa: Thank you for catching the error described below in SOAP Part 0: Primer. >I found an error in the section 6 of SOAP 1.2 Primer CR document. >In the following sentences, "env:faultReason" should be "env:Reason". >* SOAP 1.2 uses the element names env:Code and env:faultReason, respectively, >for what used to be called faultcode and faultstring in SOAP 1.1. SOAP 1.2 >also allows multiple env:Text child elements of env:faultReason qualified by xml:lang to allow multiple language versions of >the fault reason. The text has been corrected in the latest editor's copy of the Primer [1]. This closes CR Issue 413. Thank you, Nilo Mitra Editor, SOAP primer [1] http://www.w3.org/2000/xp/Group/2/06/LC/soap12-part0.htmlReceived on Monday, 24 February 2003 16:41:59 UTC
This archive was generated by hypermail 2.3.1 : Tuesday, 6 January 2015 20:16:59 UTC


text:
There are currently no links available for this content.
Maigret's Dead Man in streaming. Maigret plunges into the murky Parisian underworld.
Russel Dean, Peter Schueller, Leo Staar, Karen Gagnon, Dénes Bernáth, Mark Hadfield, Dorottya Hair, Grant Stimpson, Iván Fenyö, Matt Devere, Shaun Dingwall, Hugh Simon, Rowan Atkinson, Ian Puleston-Davies, Mark Heap
Directors: Jon East
Duration: 88 min
Year of release: 2016
Click the links below to watch Maigret's Dead Man in streaming:


text:
Here are some of my favorite pictures.
Here I might put a picture of my parents.
Here I might put another picture of my friends.
Here I might put a picture of my friends and I at a previous Team Harmony event.
Here's a picture I took during a recent vacation.
If one of my friends or someone else in my family has a web site, I might include a link to it here.


text:
Another THUS potential acquisition? They are rumoured to have offered £150m for Your Comms and wont budge, while they actually want around £200m.
THUS will have to borrow the money to buy Your Comms (or extend their existing loans), they'll also needs funds to integrate and merge product lines etc.
Your Comms might bring some added value in billing platforms (consumer voice) etc.
THUS to buy Your Comms?
Posted by stevekennedyuk at 10:28 am
No comments:
Subscribe to: Post Comments (Atom)


text:
April 3, 2002
Complete Release in PDF Format
Download Free Acrobat Reader
Santa Clara vs. San Francisco
The Broncos and Waves have met 191 times on the field since the series inception in 1931. Santa Clara holds the all-time series advantage with a record of 140-50-1. Over the last five years, however, the series has been very close with the Broncos winning 12 of the last 22 meetings. The last two seasons, Santa Clara and USF were in the same division of the WCC and met six times. Both years saw the Broncos sweep the Dons at home and take one of two in the City.
Sizing Up the Dons
San Francisco enters this weekend's series at "The Shaw" having lost 11 of its last 12 games, while losing one game that has been suspended due to darkness and will be made up at a later date. That game is against LMU and was stopped with the Lions holding a 25-21 advantage over the Dons in the 10th inning before darkness halted the action. USF currently has five players that are batting above the .300 plateau, led by Joe Jacobitz who is batting .371 with two home runs and 26 runs batted in. Steve Booth is leading the Dons with 10 doubles, 12 home runs and 44 RBI to go along with his .333 average. Defensively the Dons are fielding at a .955 clip, while their opponents boast a .963 fielding average. Steve Moses leads San Francisco in appearance (17) and ERA (5.06) to go along with his 1-0 record out of the bullpen. Peter Dunkle has made six starts in his 17 appearances, and is second on the team with a 7.15 ERA. As a staff, the Dons have an 8.32 ERA with opponents hitting at a .336 clip.
Quality Starts
The Santa Clara University pitching staff has been getting quality starts in each of the last two games only to take no decisions for their efforts. Joe Diefenderfer and John Redmond combined to throw 16 2/3 innings over the last two games for the Broncos in which they allowed only four earned runs on 13 hits with seven strikeouts and only four walks. Diefenderfer threw nine full innings and took a no decsion as the Broncos fell to Pepperdine in the 10 inning by a score of 4-3 in the series finale in Malibu. Redmond threw 7 2/3 innings of great ball in which he allowed only two runs on four hits, leaving the game with the Broncos ahead by a score of 6-2. He took a no decision after Cal edged Santa Clara in the bottom of the ninth inning.
Be Fruitful and Multiply
Joey Gomes and Pat Peavey have combined for 28 multiple hit games this season for Santa Clara, with Gomes leading the way with 18. He has had two hits in 12 games this season, three hits five times and one four hit game. Peavey has collected two hits in eight games this year, while getting three base knock in two games. A.J. LaBarbera, who is on a seven-game hitting streak, has had nine multiple hit games this year, five of which have been three-hit games.
Probable Starters by Position Santa Clara San Francisco 26 Shawn Epidendio 1B 7 Nick Cirbo 1B 4 A.J. LaBarbera 2B 14 Cy Donald 2B 15 Pat Peavey SS 6 Armand Gaerlan SS 20 Dan Vincenzi 3B 8 Royce Fukuroku 3B 8 Jim Wallace C 25 Steve Booth C 35 Joe Diefenderfer LF 31 Joe Jacobitz LF 3 Jack Headley CF 24 Nick Tarbat CF 21 Joey Gomes RF 10 Ryan Sittauer RF 9 David Mandley DH 35 Alfonso Valdez DH
Probable Starting Rotation Santa Clara San Francisco 17 Chad Fillinger 3-2, 4.50 ERA 11 Bryan Williams 1-4, 7.29 ERA 18 Joe Diefenderfer 2-4, 4.42 ERA 20 Jesse Mena 2-1, 9.33 ERA 10 Matt Travis 2-1, 6.26 ERA 22 Peter Dunkle 1-4, 7.15 ERA


text:
945 Autumn Close - Alpharetta 30004
Beautifully warm and inviting home on the golf course in gated community!
Bright and sunny updated chef's Kitchen with 2 large walk-in pantries opens to fireside & vaulted Family Room with soaring palladium window.
Master Retreat boasts hardwood floors, sitting room, and gorgeous fully updated Bath. Large secondary Bedrooms & Laundry Room conveniently located up. Bedroom with full bath on main. Separate Living/Office space.
Enjoy beautiful golf course vistas and winter time sunsets from the spacious screened porch. Finished Basement with Kitchen.
Call (404) 334-3045 or email us for more information or an appointment!


text:
Here's a post by TopNotchThemes.
Minimalist, Portfolio, WooCommerce WordPress Themes
That's a look at Alder, a clean and minimal theme that has a ton of amazing features for you to consider.
Alder is a minimal, clean and modern WordPress theme, packaged with awesome premium plugins (value 108$ for free!), unlimited customizability, built-in mega menu, full WooCommerce…


text:
Sponsored By
[ This guide contributed by Neil Monteith. Disclaimer: Rock climbing is a dangerous sport. None of the information contained in this document has been verified. Treat all fixed gear with suspicion, route grades may be incorrect and the rock may be poor. The editors of this document take no responsibility for any injury arising from the use of this information. If there are mistakes in this guide then let the editor know by emailing firstname.lastname@example.com. ]
NOTE: This is now out of date. See http://www.climb.org.au/index.php?page=27&area_id=588
A small gently overhung amphitheatre of rock with a couple
of good Blue Mountains style sport routes and plenty of potential for new
routes. The orange wall is clearly visible on the hillside when driving in
from the highway past the olive grove. Walk in as for
Sentinel Cave (see:
approach map). After hopping
over a big dead tree about 8 minutes into the walk turn left and follow
small creek bed steeply uphill heading for the obvious orange wall high on
the hill. Scramble up ledges and small fixed rope to get to base of wall.
12) Ranger Danger 14m 24
13) Little George 25m 22 *
Check out the video clip
Little George (3.3
Meg, 53 seconds) - In the setting sun, Jacqui Middleton grabs the FFA. Jac's smooth,
leisurely pace appears more dynamic in this footage edited to reduce file


text:
Okay, today started out kind of crazy. My two girls (Collette 10 & Lauren 6) have this thing about "crafting" in the mornings (and I use the term crafting very, very loosely). Lauren is a great artist and is very meticulous about getting everything just right, but Collette is kind of a "free art" kiddo. She can spend hours just cutting up pieces of white paper and sticky taping them onto another white paper and calls it "art" - I guess, in a way it is (would probably look great in some minimalist gallery or something).
Anyway, today after they finish breakfast they decide it's a marker kind of art morning and proceed to fight over who is going to use which marker (even though there are several of each color in the box). They end up fighting and Collette writes on Lauren's face with pink marker. This is all happening at about 6:45am mind you - WAAAY too early for me to want to deal with any of this. Lauren tries to wash the marker off her chin and, of course, it won't come all the way off - so now she has to go to school with a big pink mark across her chin.
On top of that, Collette has decided that her nose is stuffy and maybe she shouldn't go to school today (could it be because her sister had a field trip to the pumpkin patch today and if she doesn't go to school maybe she can come too???....hmmmm). Collette doesn't have a fever so it's probably just allergies and she IS going to school. Now the morning parade of "Help Me!'s" to get dressed begins and as I'm trying to finish my makeup, each child proceeds to parade into my bathroom carrying an assorted clothing item for my assistance to put on them (Yes, they CAN get dressed by themselves....buy why should they when Mom will help?)
Finally, everyone is dressed and out the door....Whew!...I have exactly 38 minutes until I have to be at the pumpkin patch for Lauren's field trip....


text:
With acres of wonderful countryside, crystal clear rivers and rippling trout streams, the Derbyshire Dales make for glorious walking and hiking terrain, and our Derbyshire Dales hotels put you within easy reach. These Derbyshire Dales hotels are great for exploring the best this natural wilderness has to offer, whether on a walking holiday or fishing break. So, let our hand-picked selection of fine Derbyshire Dales hotels make you feel right at home.
Midweek Break Hotels in Derbyshire Dales
A delightful country house on the Chatsworth Estate
Dannah Farm Country House
Belper, Derbyshire
A chic and luxurious inn on the great Chatsworth Estate
Devonshire Arms at Beeley
Matlock, Derbyshire
One of the treasures of Chatsworth in the heart of the Peak District
Cavendish Hotel
Peak District, Derbyshire
The perfect base to discover the natural beauty and heritage of the Peak District
Peak District, Derbyshire
3 Nights For the Price of 4
An English classic on the Jurassic Coast
3 Nights For the Price of 4