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Ballinkillen 7-8 Naomh Brid 2-3
Ballinkillen played very well in this game to overcome a strong Naomh Brid side and win this game in Fenagh on Saturday morning the 9th of June. Ciaran Dowling went on a scoring fest, scoring 3 goals and six points of Ballinkillen's tally. There were two points scored by Jack Treacy. The other scorers of goals for Ballinkillen were Cormac Lomax, Padraig Hynes, Jack Ryan and Conor Tracey. Best for Ballinkillen were Niall Whelan, Sean Cummins and Colin Byrne.
Ballinkillen: Cormac Lomax, Eoin Whelan, Gary Tobin, Jack Hughes, Patrick Kavanagh, Eoin Kavanagh, James Cummins, Ciaran Dowling, Niall Whelan, Colin Byrne, Cian Delaney, Craig Bermingham, Thomas O Donoghue, Jack Treacy, Jack Ryan, Sean Cummins, Padraig Hynes, Conor Tracey, Sean Smithers, Mark Foley, Jamie Ryan.
Match Reports >


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The level of risk peaked in the final quarter of 2016, as globalisation fell out of favour, and risk increased across Western Europe
Global risk in the supply chain has been increasing steadily throughout 2016, and the final-quarter stats, revealed by the CIPS Risk Index powered by Dun & Bradstreet, take the figure to its highest level since the index began in the 1990s.
Get a free 30 day trial to access all Supply Management website stories click here >
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And much more.
Click here to join >

subset: commoncrawl


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Facebook for BlackBerry smartphones has been updated to version 3.1 and is now available for download in the BlackBerry App World. The new update has included some cool new and much needed features to the app. Here's what's new:
- Added Facebook Groups Tab: You can now view and post updates, comments and media.
- Like individual comments


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Reservations Office Time:(Open: 08:00 - 17:00)
Vision House 2
53 Blaauwbwerg Rd, Cape Town 7439
South Africa
Situated in the heart of the Indian Ocean in one of the last, untouched frontiers, we are pioneering a new style of experiential travel while actively conserving this pristine region.
The Outer Islands, far from the main island Mahé, are comprised of 72 remote coral islands. Each with their own character and story. Our selected islands and atolls are the ultimate getaways.
Experience all that the Outer Islands of the Seychelles have to offer - immerse yourself in an untouched paradise with a rich biodiversity of fauna and flora.
"We had the most amazing holiday on this beautiful island. Thank you to all the dive team, conservation team and rest of the island staff for their pure dedication to keep this island as unique as it is. Also for being such an inspiration to our whole family!"
"The snorkelling and spinner dolphin safari was mind-blowing and the flats lunch delicious and surreal"
"Remote. Unreal. Incredible. Spellbinding. Romantic. Prive. You felt as if it was your own private island, with not a care in the world!"
"Utterly superb in every way. I was beyond impressed with the food and service. Beautiful venue with friendly helpful staff. This was my third visit and I look forward to the next one"
"Excellent place! Staff are friendly, food, drinks & accommodation is great and of excellent quality. You feel right at home! This is paradise! All activities are excellent."
"Perfect service with fresh food every day. Air-conditioned rooms right on the beach and one of the best destinations of the Seychelles. Love this Island and the team."
Of the 72 islands and atolls of the remote outer islands, we have selected the most pristine and enchanting four as our base. From here we can discover, experience and protect the surrounding natural wonders.
Alphonse is 400 km South West of Mahè and is the home base of Blue Safari.
Surrounded by the azure waters of the Indian Ocean, the island holds white sandy beaches, stylish accommodation, the Azure Spa, luxurious experiences and a range of exotic animals and endemic plant life.Discover The Island
Over a 1000 km from Mahè, Astove is a world filled with color.
The large lagoon and white sandy beaches are home to a plethora of bird and fish species. The impressive Wall holds impressive sheer drop-offs which makes you feel like you're staring down the Grand Canyon. A nature lovers paradise.Discover The Island
Over a 1000 km from Mahè, Cosmoledo has escaped much human interference.
An untouched ecosystem that boasts vast, sand flats, beautiful islands of different shapes and sizes and a wonderful lagoon. A new luxurious eco-camp is situated on Wizard Island.Discover The Island
Poivre is situated on the East side of the Amirantes Bank, 300 km from Mahè.
The atoll consists of two islands and its proximity to the Amirantes Trench attracts various species of pelagic animals. This is one of the crown jewels of the Seychelles.Discover The Island
Each lodge and accommodation has its own character which complements its verdant and natural setting.
An hour's flight from the main island, one will land on a discreet haven covered in coconut palms and tropical flora. With miles of unblemished shorelines, lagoons and seaflats, Alphonse Island truly is paradise in the outer islands.
Blue Safari is the premier travel provider in the Outer Islands. Our team is able to arrange the unique and ultra-luxury experiences that your heart desires. From private jets to chartering superyachts, with Blue Safari, anything is possible.
We have carefully crafted various example itineraries that highlight the unique experiences at our various island destinations.


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Ronera Matusalem, Santiago de Cuba
Ron Palmas
Ron PalmasSource of the picture:
Carta Blanca
Carta BlancaI have a picture only:(
Ron Matusalem
Ron Matusalem89 x 126 mm (3.5\" x 4.9\")
Ron Matusalem Extra Viejo
Ron Matusalem Extra Viejo107 x 121 mm (4.2\" x 4.8\")
Only 2 of 4 labels are shown. Underplayed labels are variations with minor differences.
|Related links:
Matusalem & Co.
|See also:
Alvarez Camp & Co., Ltd., Freeport
Matusalem & Co.
Here can be your link
The company started by the Camp brothers in 1872 as a family affair. It was originally called Camp & Brothers, S.A. Around 1912 Benjamin Camp moved back to Spain, from there on the company was in the hands of his brother Eduardo and Evaristo Álvarez. Eventually, one of the daughters of Evaristo Álvarez married the son of Eduardo Camp.
In the early 1900's the son of Evaristo, Claudio Álvarez LeFebre entered the company. The corporate name was then changed to Álvarez Camp & Co. The "new" Cuban rum rapidly caught on in the world's markets.
In the early 1940's Claudio Álvarez LeFebre's only son, Claudio Álvarez Soriano, joined the firm. His hard work and outstanding administrative skills earned him the respect of workers and competitors alike. From here on, the company experienced a period of tremendous growth and by the 1950's it had already captured 50% of the Cuban market.
Matusalem was the leading rum sold in Cuba. At the beginning of the year 1956 died Claudio Álvarez LeFebre and six months later Claudio Álvarez Soriano, too. That same year starts the guerrilla war against President Fulgencio Batista. By 1960 the Álvarez family, the company and the country were utterly changed - forever. It was the end of an era.
United States
In 1961 was established Matusalem & Co in U.S.A.


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Getting Started with Geographic Information Systems, Volume 1
Pearson Education, 2003 - Science - 340 pages
This best-selling non-technical, reader-friendly introduction to GIS makes the complexity of this rapidly growing high-tech field accessible to beginners. It uses a "learn-by-seeing" approach that features clear, simple explanations, an abundance of illustrations and photos, and generic practice labs for use with any GIS software. What Is a GIS? GIS's Roots in Cartography. Maps as Numbers. Getting the Map into the Computer. What Is Where? Why Is It There? Making Maps with GIS. How to Pick a GIS. GIS in Action. The Future of GIS. For anyone interested in a hands-on introduction to Geographic Information Systems.
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Common terms and phrases
allows ArcView attribute data called capabilities cartographic census Chapter choropleth map color CommunityViz coordinate system data formats data model data set data structure database management DBMS defined definition digital map display distribution earth elevation ellipsoid error example field Figure file final find first fit flat file flow functions gender ratio geocoding geographic coordinates Geographic Information Systems GIS data GIS packages GIS software GIS systems GIS user GPS receivers graphic graphical user interface grid cell Intemet layers map data map overlay map projection map type means measurement meters nodes operating system pixel points polygon query raster records reflect remote sensing retrieval satellite scale scanner scanning scientific significant spatial data specific standard deviation statistical stored surface symbols topology U.S. Census Bureau U.S. Geological Survey United Unix user interface USGS usually values visual workstation


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I hope we get some more Juliett sets sometime soon. I miss seeing her!
Geiles Mädchen, möchte sie im Bett haben
A new superstar is born – with that pretty face, gorgeous green eyes, lean body and endless slender legs, she is very very special. I hope that she becomes a regular monthly visitor for many years to come.
Hope there are more sets with Juliett coming!
like to meet her
Perfect small breasts
Perfectly shaped ass and anus
Perfect Pussy
Perfect for Porn
Sexy girl. Fine pussy!
Very beautiful girl.
She's so drop dead cute!
Very Pretty with a nice sweet smile. I look forward to seeing her many more times. Love those green eyes.
Absolutely beautiful. Juliett is as fresh as the spring wind. A friendly face, brown hair and green eyes. A girl next door, so beautiful that you can not describe it.
Beetle think you mean RED hair, but I do agree her beauty is complex to describe. Freckles, those green eyes, surrounded by her young beautiful face, scrumptious breasts, great buns, and a bottom you can spend hours on. Anothew Phew for me.
Adorable, spirited, very sexy... I really hope Juliett's not a one-hit wonder, because she's got the chops to hang around for a long time to come!


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Press Release
EMC Reports Fourth-Quarter and Full-Year 2008 Financial Results
- First-ever $4 billion-plus quarter Revenue up 8% sequentially; 5% year over year
- Fourth-quarter operating cash flow of $1.1 billion Up 9% year over year
- Record full-year revenue of $14.88 billion Up 12% year over year
- Sixth consecutive year of double-digit annual revenue growth
Dave Farmer
HOPKINTON, Mass. January 27, 2009 EMC Corporation (NYSE:EMC), the world leader in information infrastructure solutions, today reported fourth-quarter 2008 revenue of $4.02 billion, an increase of 8% sequentially and 5% year over year, representing an all-time EMC record for quarterly revenue.
Fourth-quarter GAAP net income was $288.0 million or $0.14 per diluted share, which includes a $0.10 restructuring charge. Fourth-quarter non-GAAP net income⊃1; was $646.8 million or $0.32 per diluted share, 7% higher compared with the year-ago period.
For 2008, EMC posted total consolidated revenue of a record $14.88 billion, an increase of 12% year over year and representing EMC's sixth consecutive year of double-digit annual revenue growth. GAAP net income for 2008 was $1.35 billion or $0.64 per diluted share. Non-GAAP net income1 for the full year was $2.16 billion or $1.04 per diluted share, an increase of 14% year over year.
During the fourth quarter, EMC generated operating cash flow of $1.1 billion and free cash flow of $775 million, each increasing 9% year over year. For the year, EMC's operating cash flow was $3.6 billion, an increase of 14% compared with 2007, and free cash flow was $2.6 billion, an increase of 17% year over year.
Joe Tucci, EMC Chairman, President and Chief Executive Officer, said, "EMC's ability to achieve record financial results despite the macro-economy was driven by tight alignment with key customer priorities; the strongest and most integrated product, services and partner portfolio in company history; and solid execution throughout the year. We've entered 2009 with a robust and diversified business model, which we intend to leverage to extend our technology lead and gain market share."
Tucci added, "EMC has a firm grasp on what's required to thrive in tough times and emerge even stronger in the next growth cycle. We remain intensely focused on customers' top priorities – saving money, attaining a faster ROI, reducing risk and preparing for the delivery of next-generation data centers. Finally, we remain committed to investing heavily in research and development to extend our technology lead and maintain rapid product rollout cycles."
David Goulden, EMC Executive Vice President and Chief Financial Officer, said, "Financial strength and flexibility are high on the list of EMC's most strategic advantages. Throughout 2008 we managed our spending carefully, while reinvesting in future growth opportunities, strengthening the competitiveness of our solutions and extending our market leadership. Through 2009 we will continue to streamline operations, reduce costs and strengthen the efficiencies of our global operations."
EMC's best estimate is that 2009 global IT spending will decline as a percentage in the mid to high single digits compared with 2008. The company expects the markets that it addresses will perform slightly better than the overall IT market. The company also expects that a higher than usual percentage of the full-year IT spending will take place in the second half of the year.
Fourth-Quarter Highlights
EMC's Information Infrastructure business revenue for the fourth quarter – comprising Information Storage, RSA Security, and Content Management & Archiving – was $3.5 billion, an increase of 8% sequentially and up 2% compared with the year-ago period. This growth reflects the completeness of EMC's broad portfolio of products and services uniquely suited to help customers address the growth and management of information and drive cost savings across their IT environments.
Fourth-quarter Information Infrastructure business highlights included strong customer demand for EMC's:
- Industry-leading networked storage solutions, with particularly strong revenue growth from EMC's unified storage systems that connect to a variety of networks.
- Broad portfolio of industry-leading backup, recovery and archive solutions that leverage data de-duplication to meet their data protection requirements, reduce cost and mitigate risk.
- RSA security information & event management (SIEM) solutions and the RSA data loss & prevention (DLP) suite.
- Services portfolio that spans across EMC's Information Storage, RSA Security and Content Management & Archiving business units.
VMware (NYSE: VMW), which is majority-owned by EMC, contributed fourth-quarter revenue of $514 million.
EMC consolidated fourth-quarter revenue from the United States increased 6% compared with the same period a year ago. Fourth-quarter revenue from EMC's operations outside of the United States grew 4% year over year and represented 46% of total fourth-quarter revenue.
2008 Highlights
Full-year 2008 consolidated revenue was $14.88 billion, 12% higher than the year-ago period. EMC's Information Infrastructure business grew revenue 9% year over year to $13.0 billion, driven by the introduction of new, industry-leading products, the quality and breadth of EMC's global services portfolio, technology integrations and product enhancements from across all business units, strengthening the company's market leadership and competitiveness.
In addition, VMware contributed revenue of $1.88 billion.
Full-year 2008 consolidated revenue from EMC's operations outside of the United States grew 17% year over year and represented 46% of total annual revenue, with the Europe, Middle East & Africa (EMEA), Asia-Pacific & Japan (APJ) and Latin America regions posting double-digit year-over-year revenue growth. Revenue from EMC's United States operations increased 9% compared with 2007 and represented 54% of total annual revenue.
Certain Items Impacting 2009
The following statements are based on current expectations. These statements are forward-looking, and actual results may differ materially. These statements do not give effect to the potential impact of mergers, acquisitions, divestitures or business combinations that may be announced or closed after the date hereof. These statements supersede all prior statements regarding 2009 financial results set forth in prior EMC news releases.
All dollar amounts and percentages set forth below should be considered to be approximations.
The following items are expected to impact EMC's 2009 results:
- Savings from EMC's restructuring program are expected to reduce the company's 2008 cost base by $350 million, with about a third benefiting cost of sales and the remaining representing lower operating expenses. The savings are expected to be weighted toward the latter half of 2009.
- Transition costs in 2009 are expected to be $60 million, primarily impacting operating expenses.
- The net impact of lower software capitalization and increased amortization under Statement of Financial Accounting Standard No. 86, "Accounting for the Costs of Computer Software to be Sold, Leased, or Otherwise Marketed," is expected to increase total costs and expenses by $100 million in 2009.
- The adoption of FASB Staff Position No. APB 14-1, "Accounting for Convertible Debt Instruments that May be Settled in Cash upon Conversion (Including Partial Cash Settlement)" ("FSP No. APB 14-1") is expected to cause a non-cash increase to interest expense of $108 million in 2009.
- Interest income in 2009 is expected to be $70 million lower than 2008 due to lower interest rates.
- EMC expects transition costs, net impact of software capitalization and amortization, adoption of FSP No. APB 14-1 and reduced interest income to reduce both GAAP and non-GAAP diluted earnings per share by $0.12 in 2009 compared to 2008.
- Restructuring expenses in 2009 are expected to be $75 million.
- The GAAP tax rate is expected to be 18%. The non-GAAP tax rate excluding stock-based compensation, intangible amortization and restructuring is expected to be 21%.
Due to the current macro-economic conditions and limited visibility, EMC is not offering revenue, EPS or other financial outlook at this time.
Supporting Resources
- EMC will host its 2008 fourth-quarter and full-year earnings conference call today at 8:30 a.m. ET, which will be available on EMC's web site at http://www.emc.com/about/investor-relations/index.htm
- Additional information regarding EMC's financials, as well as a webcast of the conference call, will be available at 8:30 a.m. ET at http://www.emc.com/about/investor-relations/index.htm
Visit http://ir.vmware.com for more information about VMware's fourth-quarter and full-year financial results
About EMC
EMC Corporation (NYSE: EMC) is the world's leading developer and provider of information infrastructure technology and solutions that enable organizations of all sizes to transform the way they compete and create value from their information. Information about EMC's products and services can be found at www.EMC.com
1 Items excluded for the fourth quarters of 2008 and 2007 from the non-GAAP results are stock-based compensation, intangible amortization, restructuring and IPR&D charges. Items excluded for full-year 2008 and 2007 from the non-GAAP results are stock-based compensation, intangible amortization, restructuring and IPR&D charges and special income tax benefits. Additionally, net gains on investments, including the gain on the sale of VMware stock was excluded in the full-year 2007 non-GAAP results. See attached schedules for reconciliation of GAAP to non-GAAP.
EMC is a registered trademark of EMC Corporation. RSA is a registered trademark of RSA Security Inc. VMware is a registered trademark of VMware, Inc. All other trademarks used are the property of their respective owners.
Forward-Looking Statements
This release contains "forward-looking statements" as defined under the Federal Securities Laws. Actual results could differ materially from those projected in the forward-looking statements as a result of certain risk factors, including but not limited to: (i) adverse changes in general economic or market conditions; (ii) delays or reductions in information technology spending; (iii) our ability to protect our proprietary technology; (iv) risks associated with managing the growth of our business, including risks associated with acquisitions and investments and the challenges and costs of integration, restructuring and achieving anticipated synergies; (v) fluctuations in VMware, Inc.'s operating results and risks associated with trading of VMware stock; (vi) competitive factors, including but not limited to pricing pressures and new product introductions; (vii) the relative and varying rates of product price and component cost declines and the volume and mixture of product and services revenues; (viii) component and product quality and availability; (ix) the transition to new products, the uncertainty of customer acceptance of new product offerings and rapid technological and market change; (x) insufficient, excess or obsolete inventory; (xi) war or acts of terrorism; (xii) the ability to attract and retain highly qualified employees; (xiii) fluctuating currency exchange rates; (xiv) the impact of any expense reduction initiatives; and (xv) other one-time events and other important factors disclosed previously and from time to time in EMC's filings with the U.S. Securities and Exchange Commission. Statements in this release regarding market conditions are based on current expectations. These statements are forward-looking, and actual results may differ materially. EMC disclaims any obligation to update any forward-looking statements in this release after the date of this release.
Use of Non-GAAP Financial Measures
This release contains non-GAAP financial measures. These non-GAAP financial measures, which are used as measures of EMC's performance or liquidity, should be considered in addition to, not as a substitute for, measures of EMC's financial performance or liquidity prepared in accordance with GAAP. EMC's non-GAAP financial measures may be defined differently from time to time and may be defined differently than similar terms used by other companies, and accordingly, care should be exercised in understanding how EMC defines its non-GAAP financial measures in this release.
Where specified in the accompanying schedules for various periods entitled "Reconciliation of GAAP to Non-GAAP," certain items noted on each such specific schedule (including, where noted, amounts relating to stock-based compensation expense, intangible amortization, special income tax benefits, restructuring charges, IPR&D charges and net gains on investments) are excluded from the non-GAAP financial measures.
EMC's management uses the non-GAAP financial measures in the accompanying schedules to gain an understanding of EMC's comparative operating performance (when comparing such results with previous periods or forecasts) and future prospects and excludes the above-listed items from its internal financial statements for purposes of its internal budgets and each reporting segment's financial goals. These non-GAAP financial measures are used by EMC's management in their financial and operating decision-making because management believes they reflect EMC's ongoing business in a manner that allows meaningful period-to-period comparisons. EMC's management believes that these non-GAAP financial measures provide useful information to investors and others (a) in understanding and evaluating EMC's current operating performance and future prospects in the same manner as management does, if they so choose, and (b) in comparing in a consistent manner the Company's current financial results with the Company's past financial results.
This release also includes disclosures regarding free cash flow which is a non-GAAP financial measure. Free cash flow is defined as net cash provided by operating activities less additions to property, plant and equipment and capitalized software development costs. EMC uses free cash flow, among other measures, to evaluate the ability of its operations to generate cash that is available for purposes other than capital expenditures and capitalized software development costs. Management believes that information regarding free cash flow provides investors with an important perspective on the cash available to make strategic acquisitions and investments, repurchase shares, service debt and fund ongoing operations. As free cash flow is not a measure of liquidity calculated in accordance with GAAP, free cash flow should be considered in addition to, but not as a substitute for, the analysis provided in the statement of cash flows.
All of the foregoing non-GAAP financial measures have limitations. Specifically, the non-GAAP financial measures that exclude the items noted above do not include all items of income and expense that affect EMC's operations. Further, these non-GAAP financial measures are not prepared in accordance with GAAP, may not be comparable to non-GAAP financial measures used by other companies and do not reflect any benefit that such items may confer on EMC. Management compensates for these limitations by also considering EMC's financial results as determined in accordance with GAAP.
Additional Information
- Dell, EMC Extend and Expand Strategic Alliance
- Microsoft and EMC's RSA Security Division Team Up to Help Customers Secure Sensitive Data
- EMC Customers Achieve Significant Savings with De-duplicated Backup and Archive
- EMC Forms Decho Corporation To Address The Growing Personal Information Challenge
- New Iomega Storcenter ix2 Brings Leading EMC Network Storage Technologies to Home and Small Business Users


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Courtesy of Bridal Extravaganza of Atlanta
If you're looking for a great way to kick-start your wedding planning and meet a ton of vendors in one place, check out the Bridal Extravaganza of Atlanta, which will be held on Sunday, August 15th from 1 to 5 p.m. at the Crowne Plaza Atlanta Perimeter at Ravinia. There will be lots of wonderful vendors to meet with, from florists to photographers, fashion shows, hors d'oeuvres and wedding cake tastings, a special honeymoon expo, and the chance to win prizes including a $25,000 wedding shopping spree and a honyemoon. Admission is $10 in advance, or $15 on the day of the show. Visit the Bridal Extravaganza of Atlanta's website for more information and to buy tickets. —Kim Forrest, Brides Atlanta


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So as many of you know today is mine and Dylan's birthday, she is now 9 and I am still 24. She was born the day the Diamondbacks won the World Series, the year on 9/11. When 9/11 happened I really had this strong feeling of why people were bringing children into this crazy world. The world seemed so crazy, well 9 years later it is still a crazy world and I have 4 more children to wonder about. I have watched as Dylan has grown and seen The Lord's plan for her. I have seen how her strong, fighting, fierce, understanding, wild spirit has taken shape to deal with the onslaught the world has to offer her generation. I have often wondered
if this world can withstand the force of goodness she is just barely coming to understand she has, or if the world will fight to bring her down? I know the world will fight her, but I believe that she was sent to me so I could pass on the strength I have been given by my mother to her and her sisters. They will need this strength to make it in the world today and tomorrow. The fight she will face, she will not face alone. She will have the past generations of strong women to help her along the way. Her great-grandma Garrett, who raised 10 kids and was married during WWII, her grandma Gibbons who was raised in a family of 10 and was in the middle of 6 boys, three older three younger, and me who has shown her that education can change everything and The Lord will make it all possible. She has learned that no matter what stick to your guns, and then the going gets tough, the tough get going, so pull your butt up off the ground and get going. Happy Birthday Dylan!
If this didn't make you cry, let me know and I will try harder next time. It made me cry.


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Haunted SoulsKathryn Knight
June 2016
Four years ago, Emily Shea and Staff Sergeant Brett Leeds agreed to part with no strings attached. Sparks flew during their brief affair, but fate intervened, sending Brett overseas. When an unexpected pregnancy derailed Emily's own plans, her attempts to locate Brett were soon overwhelmed by the challenges of single motherhood. Now, Brett has returned home, and Emily is forced to share her secret.
Despite feeling betrayed, Brett is determined to forge a relationship with their son, Tyler. As the former lovers battle both their inner demons and their mutual desire, another presence enters their lives—Tyler's imaginary friend. Soon, however, the chilling evidence points to a different conclusion: a ghost has formed a dangerous connection with their son. Emily's attempts to help both a lost soul and a friend in need spiral toward a deadly confrontation, and Brett must race to save Emily before he loses her again—forever.
Between The Pages
A second chance romance with two extra side plots. The connection of Emily and Brett is the main focus of this story as they renew their friendship and chemistry. However, the ghostly addition of their son's imaginary friend was my favourite part of this story as it added an interesting mystery. The author also touched on a domestic abuse situation which was written well. The scenes with Tyler communicating with his imaginary friend are captivating, and the details behind the mystery hold your attention. The author does a great job of mixing a bit of haunting into a romance.
4 Stars


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Recipe Flash: Tomato & Dinner Roll Panzanella
SALAD BUFFET: Tomato & Dinner Roll Panzanella; String Beans with Mustard Dressing and Cured Shallots; Blue Potato & Green Onion Salad; Lemony Tarragon Chicken Salad
Tomato season is here! We know we can't resist all the tomatoes this time of year, and since we assume you can't either, all our August Recipe Flashes will feature them in an ode to the season. Here goes…
On Monday, as I was baking off a second vanilla cake layer for the birthday cake in yesterday's book photo shoot, I was listening to The Splendid Table, Lynne Rossetto Kasper's radio show, on podcast. Though the cake batter looked pretty good, and tasted even better, Lynne's go-to summer salad, which she described on air, sounded a whole lot more like lunch.
Bread Salad is hearty but simple, filling without being wintry, and as Lynne's description went on, I mentally compared her steps to what I had in my fridge. Leftover bread: check (dinner rolls from a recent catering event). Tomatoes: check (cherry tomatoes, from the farmstand). Spices: check. Oil: duh. Vinegar: of course. I followed the guidelines to the letter, moistening stale bread with water and vinegar, and seasoning tomatoes with oil and spices. Still, the beauty is that they are just guidelines; my salad is made-up, perhaps not much like any of Lynne's, and the variations on it are limitless.<
From my kitchen, albeit small, to yours,
Cara, THE QUARTER-LIFE COOK
1 1/2 dinner rolls, torn into bite-sized pieces (or about ¾ cup of any torn bread)
2 teaspoons white wine vinegar
1 tablespoon olive oil
¼ teaspoon smoked paprika
¼ teaspoon salt
pinch red pepper flakes
2 tablespoons scallions, white and light green parts, plus more for garnish
about 1 ½ cups halved cherry tomtaoes
2 tablespoons crumbled feta
Arrange the bread in a bowl. Sprinkle with several teaspoons of water and the white wine vinegar, to moisten it. Set aside for 30 minutes.
Warm the olive oil in a small saucepan over medium heat. Add the paprika and red pepper flakes, and cook for about 2 minutes, until fragrant. Add the scallions and and salt, and cook until they're just wilted, another minute or two.
Place the tomatoes in the bowl you'll eat out of. Pour this oil over them, tossing to mix. Taste for salt. Add the feta and the moistened bread and toss to distribute evenly.
Grind black pepper over the top. Garnish with a few extra scallions if you'd like.


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Our Brands
As well as creating individual ranges for clients across the major supermarkets and other customers, we also have a selection of our own brands including Spice of Life – a delicious range of Indian snacks and meal accompaniments and Mrs Lam's – great tasting Chinese and oriental snacks.
Ideal for customers looking for a tertiary brand, we can also add to this range to meet your individual requirements. We can innovate across cuisines to develop a range of tastes, products and flavours for a particular season, theme or promotion.


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Is your application, server, or service delivering the appropriate speed of need? How do you know? Are you 100-percent certain that your latest feature hasn't triggered a performance degradation or memory leak? There's only one way to verify - and that's by regularly checking the performance of your app.
But which tool should you use for this? In this blog post, we'll review the pros and cons of the leading open-source solutions for load and performance testing.
If you're like many, chances are you've already seen this great list of 53 of the most commonly used open source performance testing tools. However, the truth is many of these tools aren't necessarily suited to our needs. Some are limited to the HTTP protocol. Some haven't been updated for years. Most aren't flexible enough to provide parametrization, correlation, assertions and distributed testing capabilities. Given the challenges most of us face today, I would whittle this down to a short list of the following four options that we will review in this post:
- The Grinder
- Gatling
- Tsung
- JMeter
- Locust
We'll cover the main features of each tool, show a simple load-test scenario, and display sample reports. At the end, you'll find a comparison matrix to help you decide which tool is best for your project.
Just as a short note, if you are looking for a way to automate these open source tools, BlazeMeter created Taurus, our own open source test automation tool that exends and abstracts most of the above tools (as well as Selenium), and helps to overcome various challenges. Taurus provides a simple way to create, run and analyze performance tests. Make sure to check it out.
For our comparisons we will use a simple a HTTP GET request from 20 threads with 100,000 iterations. Each tool will send requests as fast as it can.
The server side (application under test):
CPU: 4x Xeon L5520 @ 2.27 GHz
OS: Microsoft Windows Server 2008 R2 x64
Application Server: IIS 7.5.7600.16385
The client side (load generator):
CPU: 4x Xeon L5520 @ 2.27 GHz
OS: Ubuntu Server 12.04 64-bit
Load test tools:
The Grinder is a free Java-based load-testing framework available under a BSD-style open-source license. It was developed by Paco Gomez and is maintained by Philip Aston. Over the years, the community has also contributed many improvements, fixes, and translations. The Grinder consists of:
- The Grinder Console - This GUI application controls various Grinder agents and monitors results in real time. The console can be used as a basic interactive development environment (IDE) for editing or developing test suites.
- Grinder Agents - Each of these are headless load generators can have a number of workers to create the load
Key Features of The Grinder:
- TCP proxy to record network activity into the Grinder test script
- Distributed testing that scales with an the increasing number of agent instances
- Power of Python or Closure, combined with any Java API, for test script creation or modification
- Flexible parameterization, which includes creating test data on the fly and the ability to use external data sources like files and databases
- Post-processing and assertion with full access to test results for correlation and content verification
- Support of multiple protocols
The Grinder Console Running a Sample Test
Grinder Test Results:
The Gatling Project is another free and open source performance testing tool, primarily developed and maintained by Stephane Landelle. Gatling has a basic GUI that's limited to test recorder only. However, the tests can be developed in easily readable/writable domain-specific language (DSL).
Key Features of Gatling:
HTTP Recorder
An expressive self-explanatory DSL for test development
Production of higher load using an asynchronous non-blocking approach
Full support of HTTP(S) protocols and can also be used for JDBC and JMS load testing
Multiple input sources for data-driven tests
Powerful and flexible validation and assertions system
Comprehensive informative load reports
The Gatling Recorder Window:
An Example of a Gatling Report for a Load Scenario
If you are interested in more information about Gatling, view our on-demand webcast Load Testing at Scale Using Gatling and Taurus.
Tsung (previously known as IDX-Tsunami) is the only non-Java-based open-source performance-testing tool in this review. Tsung relies on Erlang, so you'll need to have it installed (for Debian/Ubuntu, it's as simple as "apt-get install erlang"). Tsung was launched in 2001 by Nicolas Niclausse, who originally implemented a distributed-load-testing solution for Jabber (XMPP). Several months later, support for more protocols was added and, in 2003, Tsung was able to perform HTTP Protocol load testing. Today, it's a fully functional performance-testing solution with the support of modern protocols like websockets, authentication systems, and databases.
Key Features of Tsung:
- Inherently distributed design
- Underlying multithreaded-oriented Erlang architecture simulates thousands of virtual users on mid-range developer machines
- Support of multiple protocols
- A test recorder that supports HTTP and Postgres
- Metrics for operating systems for both the load generator and application under test can be collected via several protocols
- Dynamic scenarios and mixed behaviors. Flexible load scenarios let you define and combine any number of load patterns in a single test
- Post processing and correlation
- External data sources for data driven testing
- Embedded easily-readable load reports that can be collected and visualized during load
Tsung doesn't provide a GUI for test development or execution. So you'lll have to live with shell scripts, which are:
- Tsung-recorder, a bash script that records a utility capable of capturing HTTP and Postgres requests and that creates a Tsung config file from them
- Tsung, a main bash control script to start/stop/debug and view test status
- Tsung_stats.pl, a Perl script to generate HTML statistical and graphical reports. It requires the gnuplot and Perl Template library. For Debian/Ubuntu, the commands are:
- apt-get install gnuplo
- apt-get install libtemplate-perl
The main tsung script invocation produces the following output:
Running the test:
Querying the current test status:
Generating the statistics report with graphs can be done via the tsung_stats.pl script:
Open report.html with your favorite browser to get the load report. A sample report for a demo scenario is provided below:
A Tsung Statistical Report
A Tsung Graphical Report
Apache JMeter™ is the only desktop application in this review. It has a user-friendly GUI, making test development and debugging much easier. The earliest version of JMeter available for download is dated March 9, 2001. Since then, JMeter has been widely adopted and is now a popular open-source alternative to proprietary solutions like Silk Performer and LoadRunner. JMeter has a modular structure, in which the core is extended by plugins. This means that all implemented protocols and features are plugins that have been developed by the Apache Software Foundation or online contributors.
Key Features of JMeter:
Cross-platform. JMeter can run on any operating system with Java
Scalable. When you need a higher load than a single machine can create, JMeter can execute in a distributed mode, meaning one master JMeter machine controls a number of remote hosts.
Multi-protocol support. The following protocols are all supported out-of-the-box: HTTP, SMTP, POP3, LDAP, JDBC, FTP, JMS, SOAP, TCP
Multiple implementations of pre- and post-processors around sampler. This provides advanced setup, teardown parametrization, and correlation capabilities
Various assertions to define criteria
Multiple built-in and external listeners to visualize and analyze performance test results
Integration with major build and continuous integration systems, making JMeter performance tests part of the full software development life cycle
The JMeter Application With an Aggregated Report on the Load Scenario:
Locust in a Python-based open source framework, which enables writing performance scripts in pure Python language. The main uniqueness of this framework is that it was developed by developers and for developers. The main Locust targets are web applications and web-based services, however, if you are comfortable with Python scripting, you can test almost anything you want. In addition to that, it is worth mentioning that Locust has a completely different way to simulate users, which is fully based on the events approach and gevent coroutine as the backbone for this process. This process allows simulating thousands of users even on a regular laptop, and executing even very complex scenarios that have many steps.
Locust Key Features:
- Cross-platform, because Python can be run on any OS
- High scalability on regular machines due to events based implementation
- Power assertion ability, limited only by your own Python knowledge (you can read this article to learn more about Locust assertions)
- Nice web-based load monitoring
- Code-based scripts implementation that is handy to use with version control (Git, SVN...)
- Scalability, because you can run Locust distributed with many agents
- The ability to test almost anything with the implementation of custom samplers based on pure Python code
Basic test script example:
from locust import HttpLocust, TaskSet, task class SimpleLocustTest(TaskSet): @task def get_something(self): self.client.get("/") class LocustTests(HttpLocust): task_set = SimpleLocustTest
You can run the script by using this command:
locust -f locustfile.py --host=http://192.168.1.170:8080
After the script execution, you will find the detailed reporting on http://localhost:8089/:
While Apache JMeter represents a strong and compelling way to perform load testing, of course, we recommend supplementing that tool with BlazeMeter Load Testing Cloud, which lets you simulate up to 1 million users in a single developer-friendly, self-service platform. With BlazeMeter, you can test the performance of any mobile app, website, or API in under 10 minutes. Here's why we think the BlazeMeter/JMeter combination is attractive to developers:
• Simple Scalability – It's easy to create large-scale JMeter tests. You can run far larger loads far more easily with BlazeMeter than you could with an in-house lab.
• Rapid-Start Deployment – BlazeMeter's recorder helps you get started with JMeter right away, and BlazeMeter also provides complete tutorials and tips.
• Web-Based Interactive Reports – You can easily share results across distributed teams and overcome the limitations of JMeter's standalone UI.
• Built-In Intelligence – The BlazeMeter Cloud provides on-demand geographic distribution of load generation, including built-in CDN-aware testing.
Let's compare the load test results of these tools with the following metrics:
Average Response Time (ms)
Average Throughput (requests/second)
Total Test Execution Time (minutes)
First, let's look at the average response and total test execution times:
As shown in the graphs, Locust has the fastest response times with the highest average throughout, followed by JMeter, Tsung and Gatling. The Grinder has the slowest times with the lowest average throughput.
And finally, here's a comparison table of the key features offered by each testing tool:
|The Grinder
|Console Only
|Recorder Only
|Test Recorder
|TCP (including HTTP)
|HTTP, Postgres
|Test Language
|Python, Clojure
|Extension Language
|Python, Clojure
|Java, Beanshell, Javascript, Jexl
|Load Reports
|CSV, XML, Embedded Tables, Graphs, Plugins
|Host monitoring
|Yes with PerfMon plugin
Python knowledge required for test development & editing.
Reports are very plain and brief.
Limited support of protocols.
Scala-based DSL language knowlegde required.
Does not scale.
|Tested and supported only on Linux systems.
|Bundled reporting isn't easy to interpret.
|Python knowledge required for test development & editing.
Want to find out more about these tools? Log onto the websites below - or post a comment here and I'll do my best to answer!
The Grinder - http://grinder.sourceforge.net/
Gatling - http://gatling.io/
Locust - https://locust.io
Home Page: http://jmeter.apache.org/
JMeter Plugins: http://jmeter-plugins.org/
Blazemeter's Plugin for JMeter: http://blazemeter.com/blazemeters-plug-jmeter
On a Final Note...
As I mentioned at the start, you might also want to read more about Taurus. When it comes to performance testing, a lot of these are really great...but not perfect. Automation and integration with other systems can be a pain, and the tool itself comes with a steep learning curve. Taurus is an open source test automation tool that provides a simple way to create, run and analyze performance tests.
Want to Learn More About Load Testing With Open Source Tools?
Do you have questions about open source testing tools? View our webinar Ask the Expert: Open Source Testing with JMeter, Gatling, Selenium, and Taurus. This special interactive presentation and Q&A was hosted by Andrey Pokhilko, founder of JMeter-Plugins.org, a core JMeter contributor, and creator and lead developer on the Taurus project.
Do you want to try out JMeter? Learn for free from our JMeter academy.
Start testing now! To try out BlazeMeter, which enhances JMeter features, request a demo, or just put your URL or JMX file in the vox below and your test will start in minutes. To run Locust, Gatling, The Grinder and Tsung automatically and more easily, try out Taurus.
The parts about Locust were contributed by Yuri Bushnev.
Click here to subscribe to our newsletter.
You might also find these useful:
Taurus: A New Star in the Test Automation Tools Constellation
Navigating your First Steps Using Taurus
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Meetpoint Midlands at IGEM House, 26 and 28 High Street, Kegworth, Derbyshire, DE74 2DA
Linda Mee email firstname.lastname@example.com tel 01509 678184
A practical course designed to provide an understanding of the background, rationale and purpose of IGEM/SR/25 Ed 2.
Key outcomes/objectives
• Understanding of causes of explosions, ignition sources and thermal hazards• Consequence and risk analysis• An understanding of legislation and its application• An insight into the application of IGEM/SR/25
Course content
• Overview of IGEM/SR/25 and basic concepts underpinning the standard• Legislation and standards including DSEAR• History, scope, definitions and design principles• Zoning (out of doors, enclosures and pits)• Good and bad practice• Sample drawings• Case study worked examples
Who should attend?
This course is suitable for all those who may be asked to carry out hazardous area classification as part of a DSEAR assessment including process safety and health and safety practitioners.
Please note we highly recommend that if you attend this course you leave a period of time before booking the Application of IGEM/SR/25 calculator course to allow you sufficient time to become familiar with the calculator.


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I look young. I get that. I have been blessed with my father's genes that way. He still brags about being "proofed" in his 50s. I just roll my eyes when I hear the story for the umpteenth time (she was required to ask everyone for ID). Just because I look like I am a tad bit younger (I was once accused of being an 8th grader out at carpool duty) it does not mean that I grew up with the internet, cell phones, social media or the instant news cycle. Yet, I feel that most in my generation straddle the bridge between the industrial and information ages.
Tom Brokaw wrote of the greatest generation, a generation of elders who fought world wars and stabilized the home front. I could not agree more. Talk about a generation of resilient, creative and determined folks. When I try to think of my generation (those 35-45, or so) and what name I can give it (not gen x or gen y- how unoriginal) I come up with the "gap generation". I think it is appropriate since we are in between the industrial age (many of us were taught in the strict assembly lines of elementary schools) and the information age (it is Twitterific). Not to mention, we have all shopped at the Gap at some point. I am also part of a "last generation" that was able to get on a bike in the morning as a teenager, not really tell my mom where I was going, come home for lunch and then head back out until dinner time. No cell phone, no gps or text messaging. While I do love my pda, gps and text messaging capabilities, life was good when you had a dirt bike and a group to ride with. We built race tracks in the woods, rode a tire swing over the Bronx River and spent all the money we had at 7-Eleven on slurpies (I am sure there were some other things we did too but no interstate laws were broken- I think). I just "ratted" myself out but I figure the statute of limitations on the "house rules" ran out a while ago.
Then I get to college. We still had land lines in our room. The internet was only something you heard of (Prodigy anyone?). And yes, no email account for me. I was the only guy in our apartment with a computer. It was a glorified word processor, but it worked for us. Thankfully I never had to worry about a cell phone camera and Facebook while I was in college. A tweet was literally a sound made by a bird. So, why do I say all of this…..
It bothers me that my kids will not experience a childhood where they had a freedom to explore without the distractions of modern communication. Yes, it will be good in its own right, but still not the same. The beauty of the gap generation was not big hair, pegged jeans, z cavaricci's or capezios, it was that we were the last "group" to be able to be kids (like the olden days as my dad would say). Creativity was our license and our bike, skateboard or feet took us everywhere we wanted to go. There was no technological leash that tethered us down nor were we overprogrammed. At the very least we can help bridge that "gap" for our kids.
I may sound hypocritical here and somewhat negative about the information age, as I almost sent this entire post from my Android phone. I am a full participant in, and fan of , the "age". I am all "geared" up with tech toys. That said, I do wish that our kids had more opportunities to be free and "learn by doing". I know our world is different today, especially post 9-11 and Chris Hansen's Dateline NBC reporting, but we need to find ways to give our kids the opportunity to experience the freedom of a childhood that allows them to create, explore and problem solve.
So, here is to jumping in leaf piles on the front lawn, creating forts out of cardboard boxes and going outside to simply "play". Then take some pictures with your smartphone and post them to Facebook. People may be astonished that these activities actually do still happen. Phineas and Ferb can teach us a lesson or two about what to do in our spare time (stay tuned for part deux of this post). Maybe the Flynn boys (and their sister Candace) can help us get some of the creativity back that we seemed to lose in the "gap" between generations. To quote my friends on Phineas and Ferb, "Carpe Diem, you can't argue with latin".


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Playful Solutions, LLC is located at:
400 E. Red Bridge Road, Ste. 212
Kansas City, MO 64131
Kimberly can be contacted by phone or via email at firstname.lastname@example.com. She is happy to provide a short phone consultation to discuss your concerns, answer any questions, and schedule an appointment.
Also, like us on Facebook to stay current on everything Playful Solutions.
Playful Solutions is not affiliated with Playful Awareness.


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Shock Collars
Shock or electric collars are devices placed around a dog's neck which connect to a handheld transmitter which remotely delivers varying levels of electric shocks to the dog's neck. Having already been deemed illegal as abusive tools by many countries such as Finland, parts of Canada and parts of the United Kingdom, shock collars theoretically are designed to provide an aversive stimulus to a dog as a punishment or 'correction' from its trainer or owner.
Using shock in dog training teaches a dog to avoid a certain stimulus and to stop any behavior that 'caused' the shock, but just because the behavior has stopped in that moment does not necessarily mean the behavior has improved or will improve long-term. The shock suppresses the behavior in that moment but does not address the behavior's root cause.
Even though supporters of electronic training might praise the effectiveness of the method, dogs trained using these tools only comply or cooperate with the training out of a fear of what will happen if they do not comply – the dog is not truly being obedient.
- Shock collars may cease a behavior in the moment, but the severe stress and anxiety they cause can lead to more aggression in the future and can create entirely new behavioral problems.
- Several countries have already instated bans on shock collars, and it is only a matter of time before other countries will follow.
Rather than resort to using equipment that causes your dog fear and pain, why not try humane, force-free alternatives that are more effective long-term and that will help change the way your dog thinks and learns?
Why Should You Say NO to Shock Collars?
- Shock controls a dog without allowing that dog to make choices and solve problems, which often results in 'learned helplessness' – the dog effectively learns to give up.
- Shock forces a dog to 'behave' with little concern for the root cause of the negative behavior.
- E-collar training essentially cripples an animal's true learning ability.
- Shocking a dog can actually exacerbate aggressive behavior in the future.
There are still people who vehemently defend electronic training, saying that used correctly shock collars do not cause pain, but rather just a minor irritation that the dog learns to avoid if it behaves in a desirable manner. Even if that were the case (and it's not), why resort to shock when you can get much better results with methods that motivate a dog to behave well without force and without any possibility of physical or emotional damage?
It is impossible to defend a method that has the potential to cause real harm. Even trainers that claim to be able to use the collar 'effectively' are still inflicting some level of pain or irritation on the dog.
Yet again, the simple question at play regarding the use of shock collars is this: do you want your dog to follow you because she wants to or because she is scared of what will happen if she doesn't?
Shock collars are yet another example of man's desire for a quick fix, but positive training offers a wealth of great methods, that can dramatically change even the most severe behavioral problems in dogs.
Scientific Studies About the Effects of Shock Collars:
- Considerations for shock and 'training' collars: Concerns from and for the working dog community (Overall) Journal of Veterinary Behavior (2007) 2, 103-107
- Training Dogs With the Help of the Shock Collar: short and long term behavioural effects(Schilder, van der Borg) Applied Animal Behaviour Science 85 (2004) 319–334
- Can aggression in dogs be elicited through the use of electronic pet containment systems? (Polsky) Journal of Applied Animal Welfare Science 2000 Vol. 3 No. 4 pp. 345-357
- The Use of Shock Collars and Their Impact on the Welfare of Dogs (Blackwell, Casey) Department of Clinical Veterinary Science University of Bristol 2006
Related Reading:
- If Your Dog Could Talk: Reward v. Punishment Dog Training
- Electronic Collars vs. Traditional Leashes for Exercising Dogs on Town Streets
- The Problem with Punishment
- Victoria Blasts Shock Collars in the Chicago Tribune
- Snake Avoidance: Making Wise Choices
Positively Dog Training Episode 803
Aly and Victoria discuss how you can make your dog feel more comfortable during the holidays. Whether your dog is shy of people or...
Positively Dog Training Episode 802
In this podcast, Victoria and Aly share great ideas on how to provide enrichment for your dog when it's cold outside. Aly shares...
Positively Dog Training Episode 801
Victoria is joined by Victoria Stilwell Academy's Curriculum Manager, Aly Lecznar, to talk about VSA's newly-launched Online Dog...
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- Should We Even Talk To 'The Other...
- It's Me or the Dog Free on YouTube!
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- Isn't It Amazing?


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Below are a few of the exciting things going on in and around Shaw this weekend.
1. Easter Brunch at Acadiana- This Easter Sunday from 11am - 5pm, Acadiana will offer their three-course prixe-fixe brunch menu for $32 a person, which includes a complimentary mimosa or bloody mary. To view Acadiana's Sunday Brunch Menu, click here, and scroll down to "Eye-Opener Brunch".
2. Grand Opening Festivities at Old City Green on Saturday - Enjoy a 10% discount all weekend, but be sure to attend the dedication of Community Peace Garden at Old City Green, which takes place at 12pm.
3. Easter Brunch at Vinoteca - Vinoteca will offer an Easter brunch buffet this Sunday from 11am to 3pm. For $35 per person, you will enjoy a gourmet selection of brunch dishes as well as a pitcher of mimosa, bellini, or kir for your table (Pitchers are limited to one per four people per table)!!! Make your reservation today!
4. Plant Trees and/or Roll Easter Eggs at Common Good City Farm this Saturday - Common Good City Farm is the new incarnation of the Seventh Street Garden and is now located at the Gage School grounds (located at 2025 3rd St NW, 3rd & V Streets, NW) in LeDroit Park. Two notable events occur there this Saturday, April 11. First, from 9am to 11pm is a workday in which Casey Trees and Common Ground will plant 20 fruit trees (all tools and light snacks provided. Kids are welcome if accompanied by an adult). Second, there will be an Easter Egg Roll and some fun activities for the whole family after the morning's work is complete. White House signature eggs will be given as prizes.
5. Countdown to Yuri's Night Party at Warehouse Arts Complex - This sci-fi event incorporates a gallery show, music, and performance as a gateway to celestial celebration. Tickets are $20 in advance and available on this website.
Know of others? Let us know in the comments!


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Promark / Kimberly Thompson Signature Drumstick
Sold Out
Product Details
Designed by Kimberly Thompson, this signature stick is a long 7A with a small beaded tip, measuring .535" in diameter and 16 ½" in length. The length gives this 7A a lot of power, while the tip offers clear articulation and delicacy when it's needed. Finally, the color of the stick is a glam orange with a bit of shimmer.


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The contract will include projects for the city's year as European Capital of Culture in 2010 and a longer-term framework for the historic Sur-i Sultani area over the next 20 years.
'It's an enormous privilege to contribute to a project like this,' said Metaphor director Stephen Greenberg. 'This is a strategic vision for a museum quarter that I believe will be world class.'
The area covered by the contract includes the city's archaeological museum, the Imperial Mint, historic church Hagia Irene and the area around Topkapı Palace.
Metaphor will consider how to display a huge range of artefacts – including objects from the Ottoman, Byzantine and Hellenic periods – remodel the Mint, and signpost the site.
Greenberg claims the collections and archived material are 'phenomenal' and, unlike most similar projects, they all come from the local area. He said: 'When you're standing on site, you'll get an idea of several thousand years of its history.'
Metaphor also worked on the Grand Egyptian Museum in Cairo and 35 new galleries for Oxford's Ashmolean Museum.
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Instructions to Expedite your Work Order Request
- Login to your account using internet explorer (This is the same place you make your payment online. You can call the office to get your login information if you don't remember it.)
- You will be able to track the work order's progress.
- You will be copied the moment the work order is assigned to maintenance.
- You will help speed up the work order progress and it keeps a history of ALL work orders submitted by you.
- You will see this when login in to your account
- Click on "Requests"
- Click on "Submit A New Requests"
- Fill in all the details regarding your maintenance request (including pictures if possible)
- Most emergency work orders are completed within 24-48 hours. Most non-emergency work orders can be completed within 10 days.


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Saturday, 23 December 2017
Gingerbread Hot Chocolate with Mini Star Ice Cream Sandwiches - Bakemas Day 23
How is it Christmas Eve TOMORROW, this month has flown by way too fast; I've not watched enough Christmas films and I've definitely not stared at enough Christmas trees!
Normally Christmas Eve would be hot chocolate day because it's super simple to throw together and you don't generally have to run around getting ingredients for it you can just thrown it together curl up and enjoy your day however, I've been posting drinks on Saturdays so I figured I'd stick with the Saturdays and I have something a little different in mind for tomorrow.
How flippin' cute are these mini ice cream sandwiches!
I love hot drinks and ice cream it's the best combination but bite sized ice cream sandwiches! They're just on another level...or maybe they're a little extra, either way they're flippin' adorable! I say this every time I talk about about ice cream sandwiches, I just love the process of making them I don't think I'll ever get tired of it so I couldn't resist making some for this hot chocolate. IF you have any leftover gingerbread lying around this is the perfect opportunity ti use it.
Anyway, the hot chocolate; I used fresh ginger to give it that subtle spicy warmth you get from ginger and added a little molasses to add the gingerbread flavour, sweetened with honey or agave syrup and I'd say that's a pretty healthy hot chocolate...aside from the fact I made ice cream sandwiches to go with it, really they balance each other out so now we're just on and even playing field.
You will need
¾" slice of ginger
350ml milk, I used cashew
2 level tsps cocoa powder
½ tsp molasses. I used blackstrap
1½-2 tsp honey/agave syrup
Peel the ginger, cut into four pieces and place in a saucepan with the milk on a low heat. Heat the milk and gently simmer for about 5 minutes.
While the milk is simmering, put the cocoa powder, molasses and honey/agave syrup in a little dish with a few tablespoons of milk and mix until it resembles a smooth paste.
Once the milk has simmered for 5 minutes add the chocolate paste into the milk and stir. Heat until the mixture is smooth.
Serve with coconut cream/whipped cream a sprinkling of ground ginger and mini ice cream sandwiches
Recipe for the ice cream sandwiches it's here I just used a tiny star cutter and sliced the ice cream thinner.
Serves 1
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Winning the Profit Game
How to use pricing as a strategic tool to increase revenues and win the war for profitOne of the greatest pitfalls in the war for profits is corporate strategists' lack of a practical understanding of the link between overall revenues and overall costs. In Winning the Profit Game, the thought leaders at A. T. Kearney unveil a revolutionary new approach to establishing clear, strategic links between the top and bottom lines. No dry academic treatise, Winning the Profit Game is a guide to growing profits, in boom times and bust, using smart top-line strategies that optimize price, costs, customer behavior, and volumes. The authors clearly lay out the basic principles involved and also include:Proven strategies for transforming added value into revenues and winning the war for profitsPrescriptive frameworks for putting the principles and strategies into action, immediatelyNumerous success stories based on experiences of A. T. Kearney clients worldwide
Weiterlesen weniger lesen


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New guys are in the shop, plus that very special guy in front will be going to live with a lucky person (maybe you!) He's number 1500, can you believe I've painted so many?? I can't. I still love making these little guys. If you want a chance to win #1500, follow me on Instagram @aimee0ray you'll find out how to enter. Good Luck!
xo aimee


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People who are involved in SEO know the complexity and uncertainty of the industry. Google does constant updates to its algorithm and moreover keeping pace with the Google's 200 ranking factors is not an easy task. Quality contents remain to be the highest focus in 2018's SEO. Apart from the content, there are few more […]Read More
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Today at Kraftin' Kimmie Stamps we are sharing TWO incredible new sets by the totally talented Emilie Goulet!!! I've gotta say, I've been itchin' to share these AWESOME new images with you!! Wait 'til ya see!!! I've had SO many requests for this particular theme!! How many times do you need a COOL card for a TEEN???? And how hard is it to find a COOL teen stamp!??! Well, look no further because we have a set of Girls and a set of Guys!! They are called GIRLS JUST WANNA HAVE FUN and SMELLS LIKE TEEN SPIRIT!! Each set features THREE super awesome TEEN stamps (that totally ROCK, if I may say so) and comes with five or six coordinating and totally rockin' sentiment stamps!!
Below you will find a list of all the Krafty Girls who are sharing PEEKS with you today so grab a cup of coffee and check them out! And as you're hoppin' around, be sure to leave a comment at each stop because I'm giving away both of these sets, so there will be TWO winners and I'll announce them tomorrow!!
All our new JUNE 2012 stamps will be available on Sunday at the Kraftin' Kimmie Stamps Shop!!! And come on back tomorrow because not only will we have a fantastic new challenge for you, but we'll be revealing the NEW stamps by Annie Rodrigue!!!
Now get ready for some SUPER FUN creations!!!


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Back to Basics
This is a full day programme where we look at your life in all the areas you choose to address. Together we explore in which areas you're doing well and those in which you're not doing so well. We take a fresh approach to your life from a new understanding of how the human experience is created, and how from this understanding an infinite list of possibilities and options become available to you.
A series of 4 follow up sessions i also part of this option to help you integrate your learning in your daily life.


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|Posted: May 25, 2009
AIXTRON Receives Largest Ever Single Order From China
|(Nanowerk News) AIXTRON AG today announced that Hualei Optoelectronic Ltd., based in Hunan Province, P.R. China, has issued a purchase contract for multiple CRIUS® MOCVD systems. The tools for production of high brightness LEDs will be shipped from Q2/09 through Q4/09. This contract represents AIXTRON's largest ever single order for MOCVD systems from China. Part of this order has been recorded as order intake in Q1/2009.
|Hualei Optoelectronic President Daqing He, comments: "Our investor and parent company is very keen to shift away from reliance on heavy industry and move into high-tech. We have therefore conducted in-depth investigations on the world wide LED market; entering high brightness LED business is our strategic target for which we have decided to work closely with AIXTRON, as the strongest partner, to enable Hualei achieving our goals quickly and efficiently.
|"We will exploit the technical expertise of international partners targeting a fast entry into the LED market in order to be ready for the market upturn. This, coupled with the strong reputation of the professional and responsive service we will receive from the local AIXTRON team will guarantee our success.
|Dr. Bastian Marheineke, Vice President Sales at AIXTRON AG, adds: "Hualeis investment is very timely and representative for a China on the rise. Our company has had a strong presence in China for many years; AIXTRON was the first company to install a commercial MOCVD reactor there and since then we have enjoyed excellent relations with the leading institutes and companies.
|"Of course we are delighted to announce this, our largest single order from China to date, which reflects the enthusiasm for investment in new technology opportunities. It also reflects the strong trust in AIXTRON-based technology thanks to our worldwide reputation for dependable, first-class products, support and reliability."
|Source: AIXTRON (press release)
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Change Currency
Monteverde USA is proud to have created the world's latest leading European ink treatment formula (ITF). Enjoy peak performance with ITF which drastically improves ink-flow quality, extends cap-off time, and lubricates and protects the ink feeding systems from corrosion and clogging. Our inks are available in a variety of vibrant colors. This is a permanent color ink
Here we have made the swatch for each color and you will be able to see the actual shades.
This product hasn't received any reviews yet. Be the first to review this product!


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This hotel is NOT
The Hampton Inn Memphis-Southwind hotel at Hacks Cross Road is nestled on the outskirts of prestigious Germantown and Collierville Tennessee in the Southwind business district. This Memphis Tennessee hotel is conveniently located to the Federal Express World Headquarters Tournament Players Club-Southwind Golf Course and the Mike Rose soccer complex. The Hampton Inn hotel in Memphis Tennessee offers a variety of dining options including The Commissary in Germantown Longhorn Steakhouse and Newk*s Cafe in Collierville Ruby Tuesday Half Shell Huey*s Olive Garden East End Grill TGI Friday*s and Logan*s Roadhouse. Our complimentary shuttle offers transportation within a five-mile radius of our hotel including the Germantown and Collierville areas. The Hampton Inn Memphis-Southwind hotel in Tennessee is an upscale hotel that features 63 mini-suites with separate living space small refrigerator and microwave. All guestrooms have a 2-line phone hair dryer coffeemaker cable TV with pay-per-view movies an iron/ironing board as well as complimentary high-speed Internet access and lap desks. The Hampton Inn hotel in Memphis Tennessee features a fitness center a business center an outdoor pool and guest laundry. We also *Make it Hampton* with a new deluxe On the House breakfast with hot items connecting rooms and cribs. Laundry/valet services meeting/banquet facilities audio/visual equipment and rollaway beds are available for a nominal fee at this Memphis hotel. We love having you here at the Hampton Inn Memphis-Southwind hotel in Memphis Tennessee.
If you are the owner of a Pet Sitting or a Dog Walking business in Memphis, Tennessee and wish to add your business listing free of charge to this city please submit your info here.


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Get this course for $121 instead of original price of $300
What will you need to know or do before starting the course?
Who should take this course? Who should not?
What Will I Learn?
1 Hashing
What is the course about?
This class (and part 2) are the best courses I've ever done online. The lectures are clear, concise, and interesting. The explanations are fascinating, touching on a whole range of topics while allowing us to use and adapt the algorithms discussed in lecture. That's probably my favorite point: rather than have us blindly implement an algorithm described in lecture, the lectures invite us to adapt and use the algorithm in a real application.
Instructor's explanation of algorithms and his use of visuals were excellent and instrumental in helping me to understand the content. In general, this course is an great fit for anyone who wishes to learn about algorithms and is new to the field.


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Writer: Chris D'Arienzo Director: Kristen Hanggi Choreographer: Kelly Devine Reviewer: Fiona Hannon Sheffield's Lyceum Theatre welcomed Rock of Ages to the city last night with its promise of "big hair and big tunes", and the retro look wasn't just confined to the stage. Leather jackets, leopard print, fringing and even the odd mullet had turned out to enjoy this celebration ...Read More »
Tag Archives: Daniel Fletcher
Rock of Ages – New Theatre Oxford
Director: Kristin Hanggi Book: Chris D'Arienzo Reviewer: Bethaney Rimmer With its myriad of rock n roll anthems, and powerful choreography that makes you want to rush up on stage to join in, Rock of Ages is the ideal show for letting your hair down and having nothin' but a good time (and it don't get better than this). Featuring 31 ...Read More »
Rock of Ages – Mayflower, Southampton
Director: Kristin Hanggi Writer: Chris D'Arienzo Reviewer: Sharon MacDonald-Armitage As the smoke and neon haze of The Bourbon Room clears the audience at Southampton's Mayflower erupts to the sounds of rock guitars and a heavy drum beat. Yes Rock of Ages is in town! Set in 80's Los Angeles where big hair and power ballads rule the day and there ...Read More »
Rock of Ages – Theatre Royal, Brighton
Book by: Chris D'Arienzo Director: Kristin Hanggi Choreographer: Kelly Devine Reviewer: Gina Skillings Its 1987 on LA's Sunset strip where the hair is big, the egos bigger, Rock is king, and everyone wants to be a star. Drew (Noel Sullivan), a budding Rock star and Sherrie (Cordelia Farnworth), wannabe actress, both work at the Bourbon Room Club while they chase ...Read More »
Rock of Ages – Sunderland Empire
Book: Chris D'Arienzo Director: Kristin Hanggi Reviewer: Mark Clegg It's the mid-to-late eighties on Los Angeles' Sunset Strip. Drew (Noel Sullivan) is a budding rock musician working in a run-down club. Sherrie (Cordelia Farnworth) is a country girl, new in town and full of dreams of fame and fortune. And this being a musical, we follow the rocky path to ...Read More »
Rock of Ages – Liverpool Empire
Book: Chris D'Arienzo Director: Kristin Hanggi Reviewer: Francesca Parker The musical sensation Rock of Ages, is causing a stir at the Liverpool Empire this week. The award-winning, smash-hit production transports the audience back to The Bourbon Room in the late 80's on Sunset Strip in Los Angeles when sex, drugs, and rocking out were something of the norm. Although Rock ...Read More »
Rock of Ages – Churchill Theatre, Bromley
Book: Chris D'Arienzo Director: Kristin Hanggi Reviewer: Joanna Trainor After its two year stint in the West End finished in November, Rock of Ages is back, for its first UK tour. Though the storyline won't blow you away, with your air guitar, glowsticks and the best of 80s rock, it's impossible not to have a great evening. Hear'Say's Noel Sullivan ...Read More »
Rock of Ages – Palace Theatre, Manchester
Book: Chris D'Arienzo Director: Kristin Hanggi Reviewer: Jay Nuttall Rock of Ages landed at the Manchester Palace this week as it starts it's journey on its first ever UK Tour. While the plot is not the most exciting that musical theatre has to offer and Chris D'arienzo's script needs tightening up in places, this new cast ofRock of Agespromises to ...Read More »


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Google finds friends at the FTC
Jan. 3 - Summary of business headlines: Google comes out unscathed after anti-competition probe but angers State Department with planned North Korea trip; Stocks recede despite encouraging numbers on retail, jobs, and auto sales. Conway G. Gittens reports.
Wall Street just could not muscle up enough energy to carry on the big rally spark by the fiscal cliff deal the day before... leaving stocks to drift lower into the close. Topping the headlines: Google barely gets a slap on the wrist after a long-running probe by the Federal Trade Commission. The anti-competitive watchdog says it found little truth in allegations Google was favoring its products and hurting rivals through its dominant search engine. The search giant, however, has agreed to tweak some of its practices. But Google is in hot water with the State Department. Google's executive Chairman Eric Schmidt is heading to North Korea, along with former diplomat Bill Richardson, according to sources familiar with the matter. State Department spokeswoman Victoria Nuland says the two are free to go but....... SOUNDBITE: STATE DEPARTMENT SPOKESWOMAN VICTORIA NULAND (ENGLISH) SAYING: "They are not carrying any messages from us. Frankly, we don't think the timing of this is particularly helpful, but they are private citizens, and they are making their own decisions." No word on what Schmidt will meet or do on the trip. Google won't confirm any details. Investors received more snapshots on how the economy ended 2012. Auto sales rose swiftly last year in the biggest annual gain since 2007. Sales at stores opened more than a year topped forecasts for December and were better than a year ago, but gains were not broad based. And there's more good news - private employers added 215,000 jobs, defying expectations of a pre-fiscal cliff slowdown. The Federal Reserve is reluctant to go beyond its near $3 trillion buying spree. That's the takeaway from minutes from the Fed's December meeting, which suggests policymakers may be concerned about the impact the Fed's buying strategy will have on the markets. Finally, action in Europe was mixed with stocks up in the U.K., but down in Germany and France.


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An online calculator to calculate inverse trigonometric function arccos(x) in radians and degrees.
How to use the calculator
1 - Enter x as a real number, within the domain of arccos function such that -1 <= x <= 1 and the number of decimal places desired then press "enter". Two answers are displayed: one in radians and the second in degrees.
You may use it to explore the domain and range of arccos(x).


text: Naga loves animals. He looks after the cows and the chicken. He also makes the compost and other organic manures and concoctions that are needed for the farm. He takes care of the biogas facility. He also manages the lime mortar unit. He is committed to working on becoming a better person with each day and would love to learn yoga and meditation. He also loves plants and trees. Naga is married to Lakshmi and have a little one named Akhil. They are expecting their second child.


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Chapel Hill: Opinion
Roses and raspberries, March 5
Raspberries to the future tenants of the old Dickinson's garden supply store and nursery on East Franklin Street for leaving an eyesore on Chapel Hill's main drag for months.
Pep Boys, the new aut-parts business eventually moving in, began clearing the site before getting appropriate permits, resulting in an immediate total work stoppage, according to town spokeswoman Catherne Lazorko.
"We are working with the developer to get things looking better at the site while they complete the development review process," Lazorko said in a Jan. 8 email. "Suffice to say, we are working with the developer to ensure that they obtain necessary approvals prior to re-development activities in the future."
Suffice it to say, it's two months later. Let's see the Pep Boys put some pep into it.
Roses to Sharon Halperin, Peter Stein, and Renee Fink of the Chapel Hill-Durham Holocaust Speakers Bureau (HSB) who were recently interviewed on WUNC's "The State of Things," hosted by Frank Stasio.( tinyurl.com/lxaehs2).
On the air, Stein and Fink bravely shared their stories of growing up in Nazi-dominated Europe. These painful experiences are wounds, reopened each time they speak to students and community organizations.
Halperin and other HSB volunteers coordinate the visits of local survivors and liberators as well as offer classroom materials and other resources to teachers interested in teaching the lessons of the Holocaust. The complicated subjects of genocide, racism, anti-Semitism, and social justice are woven into the talks given by survivors. Emphasis is placed on each person's responsibility to stand up and make a difference in today's world, as well as implications for the future.
The Holocaust Speakers Bureau has launched a film project which includes the personal testimonies of our local survivors and liberators. The words of these heroic individuals, now challenged by age and illness, will be available on the HSB website, accompanied by lesson plans and classroom activities
To read more about the bureau, to volunteer and to donate to this important film project, visit holocaustspeakersbureau.org and frommemoriestohope.org.
Roses to the Governors Club Speakers Resource as it passes the 14,000 milestone – the combined total audience reached in its 378 presentations to area service clubs and community organizations.
The program, now eight years in existence, is a public service of the Governors Club community. More than 25 of the community's residents have offered their time, their acquired life knowledge and their passion free of charge on topics from "Asian Textiles" to "My Life with the N.Y. Yankees."
Among Chapel Hill-Carrboro organizations who have received GovClub Speakers programs are the Robert and Pearl Seymour Center, East Chapel Hill Rotary, Chapel Hill Carrboro Kiwanis, Golden K (Kiwanis), Peer Learning (meeting at Olin T. Binkley Memorial Baptist Church), Board of REALTORS (Lunch & Learn sessions), Carol Woods, Newcomers, Carrboro Sunrise Rotary Club, DAR, Colonial Dames of XVII Century, Hadassah, Ethical Humanists of the Triangle, Briar Chapel, University Methodist Church, Chapel of the Cross, Carolina Club, Carolina Friends of the Foreign Service, Carolina Meadows (multiple groups), and UNC-related groups including the Ronald McDonald House (Board), UNC Medical Foundation, Children's Hospital Board of Visitors, Kenan-Flagler, UNC Dental, Fed Ex Global - Asia Center and the Phillips Ambassadors.
For information on available speakers for your organization call Lowell Hoffman at 919-933-7633 or email email@example.com.


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Not necessarily; it all depends on your personal financial circumstances. For example, if the property being let is mortgaged and the mortgage, together with the related costs of property upkeep, exceed the rent you receive, then it is possible that no tax will be payable.
Income tax is payable on rent received from a property that is let. Your tax position will determine whether you pay tax or not. All profit you make from letting should be added to your other taxable income for the year, although the financial records for letting must still be kept separately.You have to pay income tax if the total of your taxable income is greater than your tax allowance.
Only those expenses incurred "wholly and exclusively" for the purpose of the let can be offset against your letting income. These might include mortgage interest, general repairs and maintenance, insurance and, of course, your agent's property management fees.
You need to keep a record of all income and expenditure incurred in relation to all lettings. The records should show to whom payments have been made and from whom income has been received.
You are. You are obliged to submit all the relevant information to the HMRC annually to account for all your letting income.
As your letting agents, we are obliged to deduct tax from all rental income, unless the HMRC provides us with an approval number from The Non-Resident Landlords (NRL) Scheme. If the property is owned by more than one person, then an approval number will be required for each party, otherwise a proportion of tax will be retained. For more information, visit www.hmrc.gov.uk/cnr/nr_landlords.htm
Still got questions? Contact Us directly.


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I attended the 14th Annual Leadership Conference, hosted by the IFA's (International Franchise Association) Women's Franchise Committee (WFC) in Orlando, Florida. The WFC is designed to develop relationships with franchising professionals, to address issues, share ideas and offer solutions related to franchising in the local communities.
The conference theme was Dare to be Bold: Taking Risks For Reward – "It's been said that if you don't risk anything, you risk even more. The great recession caused many organizations to drastically change the way they look and operate." The Leadership Conference offered the opportunity to listen to top franchise leaders share stories of bold decisions they made that would forever change the shape of their brands.
The guest speaker was Kat Cole, President of Cinnabon; Inc. a division of FOCUS Brands Inc. Cinnabon operates more than 770 franchised locations worldwide. Prior to her role with FOCUS Brands at Cinnabon, Inc., she was VP of Training and Development for Hooters of America, Inc.
Kat shared her story of working as a server at Hooters at the young age of 19 and was handpicked to travel to Sydney Australia to open the country's first Hooters. Kat had never flown before but she took her mother's advice and "figured it out and made it happen" flying from Jacksonville, FL to Miami to get her passport and soon after traveling to Australia. By the age of 20, Kat was traveling all over the world to conduct new employee training and opening new locations. When Kat left Hooters in January 2011 she was Vice President of Training and Development.
As Kat told her story there was a recurring message: "figure it out and make it happen." We live in a time of change and Kat told us that no amount of change can work without connections and relationships. She said the people you engage with, the connections you make and the relationships you have are with individuals that can and will be your biggest advocates.
Kat was an excellent presenter and listening to her validated decisions I have made over the last few months. Change is not easy and sometimes in order to change you must take risks. With the risks there is an uncertainty of the future. Getting pass the fear of the unknown and taking the steps to figure it out and "make it happen" is not as hard as I once thought.
Kat's encouragement to build new relationships comes easy for me. It's one of the reasons I enjoy attending conferences. I love social media and I have built strong connections using the various platforms but the in-person networking provides the face-to-face experience that I miss in the virtual world.
One of the new friendships that I built at IFA was with Tra Williams. Tra is more than 6' tall so he is not easily missed in a crowd. But what really stands out is his passion for franchising and entrepreneurship. He exudes a deep commitment to helping others succeed and a strong drive to learn and share as much as possible.
Watch this video of Tra and I am confident you too will want to learn more about him and how you can connect.
Kat was right on the mark for me. I'm more than ready to "Figure it out and make it happen". And as Dr. Beatrice Berry (author, sociologist, lecturer and educator) said; "When you walk with purpose, you collide with destiny."
On March 1st I will leave what I have known and loved (Computer Explorers) for the last 16 years to start a new career as President of Deb Evans Consulting, LLC. I am confident it will be an exciting new adventure filled with new relationships, connections and risks!


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Rutgers Cancer Institute of New Jersey
195 Little Albany Street
New Brunswick, NJ 08903-2681
Prostate cancer is the most common non-cutaneous cancer diagnosed among men and the second leading cause of male cancer death in the United States. In 2018, it is estimated that 29,430 men will die from prostate cancer. Although radiation and surgery are quite effective for localized disease, approximately 30% of men diagnosed with prostate cancer will experience disease recurrence following definitive therapy. More importantly, there is no definitive cure for men who present with metastatic prostate cancer, who have an estimated 5-year survival rate of only 29% according to data from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. In patients with metastatic disease, medical (ie, androgen deprivation therapy) or surgical castration is generally the accepted first-line therapy. Yet castration-resistant prostate cancer eventually emerges, limiting life expectancy despite treatment with secondary hormonal agents, such as enzalutamide and abiraterone, targeted to the androgen receptor, as well as immunotherapy and chemotherapy.
Dr. Kim's laboratory research interests are characterized by studies with near to mid-term translational potential. These studies focus on uncovering molecular mechanisms that govern sensitivity and resistance to anti-androgen therapy in prostate cancer and renal cell carcinoma. Over the past few years, the Kim Laboratory has investigated the role of androgens and anti-androgen therapy in the growth of renal cell carcinoma, the role of Wnt5a and bone-morphogenetic protein-6 (BMP-6) signaling in the development of castration-resistant prostate cancer and, most recently, the potential role of specific neuroendocrine mediators as markers of resistance to the nonsteroidal antiandrogen, enzalutamide, in prostate cancer.
Dr. Kim and colleagues have shown that increased androgen receptor mRNA expression is associated with poor prognosis in patients with localized renal cell carcinoma (RCC). In addition, results of recent preclinical studies involving androgen receptor-positive RCC have provided support for both androgen biosynthesis in RCC as well as the potential benefits of therapies targeted to androgen signaling pathways in this form of the disease. In the setting of prostate cancer, the Kim Laboratory has provided evidence that release of Wnt5a, a signaling glycoprotein, from bone stroma modulates androgen sensitivity in the context of prostate cancer by triggering expression of BMP-6 and cytokine ligand 2 (CCL2) in androgen-sensitive prostate cancer cells, resulting in the development of castration resistance and enhancement of bone-tumor interactions through macrophage recruitment and regulation. Illustrated in the figure below are features of the proposed mechanism by which release of Wnt5a, as mediated by bone-tumor interactions, may facilitate castration resistance in prostate cancer.
Regarding investigations of possible neuroendocrine markers of resistance to enzalutamide in prostate cancer, Dr Kim was recently awarded $954,000 from the U.S. Department of Defense to pursue these studies.
Isaac Yi Kim, MD, PhD, MBA received his PhD and MD from Northwestern University in 1996 and 1997, respectively. During this time, Dr. Kim investigated the role of transforming growth factor-β (TGF-β) in prostate cancer, showing that TGF-β gene expression is frequently downregulated in prostate cancer cells, and identifying a specific genetic alteration in TGF-β receptor type I in prostate cancer. He subsequently completed his urology residency at Baylor College of Medicine, a research fellowship in Urologic Oncology at the National Cancer Institute, and a clinical fellowship in endourology, laparoscopy, and robotics at the University of California, Irvine before joining the faculty at the Rutgers Cancer Institute of New Jersey in 2005. During his postgraduate studies, Dr. Kim extended his laboratory research to bone morphogenetic proteins (BMP-6), the largest family in the TGF-β superfamily. This work lead to a main focus of his more recent work and provided evidence that BMP-6 and cytokine ligand 2 (CCL2) can alter prostate cancer progression and sensitivity to anti-androgen therapy, in part by altering the phenotype of tumor-associated macrophages.
Lee GT, Kwon SJ, Kim J, Kwon YS, Lee N, Hong JH, Jamieson C, Kim WJ, Kim IY. WNT5A induces castration-resistant prostate cancer via CCL2 and tumour-infiltrating macrophages. Br J Cancer. 2018;118(5):670-678. PMID: 29381686; PMCID: PMC5846063.
Lee GT, Han CS, Kwon YS, Patel R, Modi PK, Kwon SJ, Faiena I, Patel N, Singer EA, Ahn HJ, Kim WJ, Kim IY. Intracrine androgen biosynthesis in renal cell carcinoma. Br J Cancer. 2017;116(7):937-943. PMID: 28253524; PMCID: PMC5379152.
Ha YS, Lee GT, Modi P, Kwon YS, Ahn H, Kim WJ, Kim IY. Increased expression of androgen receptor mRNA in human renal cell carcinoma cells is associated with poor prognosis in patients with localized renal cell carcinoma. J Urol. 2015;194(5):1441-8. PMID: 25796113.
Lee GT, Kang DI, Ha YS, Jung YS, Chung J, Min K, Kim TH, Moon KH, Chung JM, Lee DH, Kim WJ, Kim IY. Prostate cancer bone metastases acquire resistance to androgen deprivation via WNT5A-mediated BMP-6 induction. Br J Cancer. 2014;110(6):1634-44. PMID:24518599; PMCID: PMC3960605.
Lee GT, Ha YS, Jung YS, Moon SK, Kang HW, Lee OJ, Joung JY, Choi YH, Yun SJ, Kim WJ, Kim IY. DHCR24 is an independent predictor of progression in patients with non-muscle-invasive urothelial carcinoma, and its functional role is involved in the aggressive properties of urothelial carcinoma cells. Ann Surg Oncol. 2014;21 Suppl 4:S538-45. PMID: 24562935.
Kwon SJ, Lee GT, Lee JH, Iwakura Y, Kim WJ, Kim IY. Mechanism of pro-tumorigenic effect of BMP-6: neovascularization involving tumor-associated macrophages and IL-1a. Prostate. 2014;74(2):121-33. PMID: 24185914.
Lee JH, Lee GT, Woo SH, Ha YS, Kwon SJ, Kim WJ, Kim IY. BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophages. Cancer Res. 2013;73(12):3604-14.
Lee GT, Jung YS, Ha YS, Kim JH, Kim WJ, Kim IY. Bone morphogenetic protein-6 induces castration resistance in prostate cancer cells through tumor infiltrating macrophages. Cancer Sci. 2013 Aug;104(8):1027-32. PMID: 23710822.
Lee JH, Lee GT, Kwon SJ, Jeong J, Ha YS, Kim WJ, Kim IY. CREBZF, a novel Smad8-binding protein. Mol Cell Biochem. 2012;368(1-2):147-53. PMID: 24708639. PMCID: PMC4005471.
Lee GT, Jung YS, Lee JH, Kim WJ, Kim IY. Bone morphogenetic protein 6-induced interleukin-1β expression in macrophages requires PU.1/Smad1 interaction. Mol Immunol. 2011;48(12-13):1540-7. PMID: 21571370.
Lee GT, Kwon SJ, Lee JH, Jeon SS, Jang KT, Choi HY, Lee HM, Kim WJ, Lee DH, Kim IY. Macrophages induce neuroendocrine differentiation of prostate cancer cells via BMP6-IL6 Loop. Prostate. 2011;71(14):1525-37. PMID: 21374653.
Lee GT, Kwon SJ, Lee JH, Jeon SS, Jang KT, Choi HY, Lee HM, Kim WJ, Kim SJ, Kim IY. Induction of interleukin-6 expression by bone morphogenetic protein-6 in macrophages requires both SMAD and p38 signaling pathways. J Biol Chem. 2010;285(50):39401-8. PMID: 20889504; PMCID: PMC2998138.