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Shipping will be accurately figured and confirmed. Then carefully weigh and packed. We can confirm back to you the total with shipping. Thank you for your patience. This method should save YOU costs.
Welcome to Vintage Collectibles Showcase. Featured here you will find Melmac to Metal Bookends. There is something here for everyone! A Vintage Collectibles Showcase makes your shopping safe, easy and guaranteed! This huge store is updated daily! A Vintage Collectibles Showcase buys collectible pottery and glass. A trusted, authorized Royal Doulton, Kevin Francis ceramics dealer. Vintage Collectibles Showcase. The collectibles store that is always open. Shop & order 24 hours a day - 7 days a week! Low prices every day. To view in beautiful detail, click on the photographs below.
Item #
Ganz Rustic Decorative Key Holder
This, bronze finish, wall piece is quite large and much more attractive than photo reveals. Perfect for your decor. Hang near the front or back door, bathrooms, etc. Sturdy too. Excellent gift for any well decorate home.
Circa: 2009
Condition: New
Manufacturer: Ganz
Could I have this Dance Sheet Music Anne Murray
Everyone loved this song, Could I Have This Dance. Words and Music by Wayland Holyfield and Bob House. Recorded by Anne Murray on Elektra/Asylum Records. This piece of sheet music shows an attractive picture of Anne Murray. Copyright 1980 by Maplehill Music, Vogue Music. Arrangement Copyright 1980 by Willie Nelson Music, Inc. The music shows only a little wear with a couple of small creases. It's an attrractive piece that will look great framed! Vintage.
Circa: 1980
Condition: Used
Manufacturer: Willie Nelson Music
Kevin Francis Bulldog Face Pot
Kevin Francis Face Pot! Rare Bertie Bulldog Charming Bulldog Facepot. 2 1/2 Diameter. NEW and still in original box. There come in unique gift boxes. A ring can fit inside. Very unique and collectible!
Circa: 2001
Condition: New
Manufacturer: Kevin Francis Face Pots
Woolworth Household Nail Assortment 10 oz.Tin - Vintage
Vintage Woolworth Household Nail Assortment 10 oz. Tin. There are some nails in it, but I don't know if any are original. This tin Measures 3.5 inches x 1.25 inches. There is wear on inside and outside from age and use. I don't know why, but my mother held on to this, because it belonged to my grandfather. She passed away at 94. Tin has some corrosion.
Circa: 1940
Condition: Vintage
Manufacturer: Woolworth
Beaded Hand Bags
Ganz Beaded Clutch Handbag
Love antique bags? You will go crazy for this New, Ganz Green and multi-color glass beaded clutch handbag. Be unforgetable. Wonderful, unique, imaginative gift, but buy two. You're going to want one too! Was $44.95. If beads come loose they can be easily re-stiched.
Circa: 2009
Condition: New, Mint
Manufacturer: Ganz
Pair of Christmas Holiday Animal Bells
One is a Christmas puppy dog and the other bell is a Holidiay kitty cat. 4.5 inches tall and 2.25 inches wide. They have a nicely aged patina to add to your other Christmas decorations. They belonged to my late mother. Please take good care of them. Vintage and in good condition.
Circa: 1985
Condition: Used
Manufacturer: Unknown
Beyond A Bag Pet Carriers
Ganz Red Pet Carrier - Beyond A Bag
Ganz Beyond a Bag is fabulous for a small cat or dog and issued in June 2012. May be used as a back-pack, purse or pet carrier. It expands that much! Perfect for airline travel or a short trip anywhere. Opens from a 2 1/4 inch length to 22 inches long!!! The label says 25 inches, but I'll be conservative at 22 inches. There are inner pockets to hold leashes, etc. (Sorry about the poor quality photographs. Ganz gave these to us on their site.)
Circa: 2012
Condition: New. Mint Condition
Manufacturer: Ganz
Beyond a Bag Pet Carriers
Ganz Black Portable Pet Carrier - Beyond A Bag
Ganz Beyond a Bag is fabulous for your small kitty or doggy, and issued in June 2012. May be used as a back-pack, purse or pet carrier. It expands that much! Perfect for airline travel or a short trip anywhere. Opens from a 2 1/4 inch length to 22 inches long!!! The label says 25 inches, but I'll be conservative at 22 inches. There are inner pockets to hold leashes, etc. (Sorry about the poor quality photographs. Ganz gave these to us on their site.)
Circa: 2012
Condition: New
Manufacturer: Ganz
Laurel and Hardy LE Bookends by Royal Doulton
Laurel and Hardy, Limited Edition of just 2500 in the year 1998. Royal Doulton Character Bookends, Stan Laurel and Oliver Hardy D7119 & D7120. Modelled by William Harper. Laurel (#198) and Hardy (#204) are beautifully hand painted and produced in England. Notice the low LE numbers of each. Limited Editions tend to hold or appreciate value better with the lower numbers. They are still new and never out of their boxes except to be photographed. Originally $400 in 1998!
Circa: 1998
Condition: New
Manufacturer: Royal Doulton
Ronson Metal Art Bookends
Ronson Metal Art Bookends! Really nice. Seller guaranteed us that they are authentic Ronson. There is a tag that bears that name on one of them. 5 1/2 inches tall x 4 1/4 inches Wide. They have felt bottoms, one of which is held on with taped assistance. The color is marvelous with minimum wear. Only one spire has a tiny speck of damage. Expected on oldest pieces. Excellent collectible you will enjoy for years! Vintage. Reduced from $129.95!
Circa: 1940
Condition: Vintage Good condition
Manufacturer: Ronson Metal Art
Coalport Figurines Charlton Catalogue of 1999
Still New Book. Coalport: Year 1999 Millenium Edition. Charlton Standard Catalogue of Coalport Figurines. 1st Edition! Lists name, designer, height, color, date of production and varieties of 1,100+ figurines! A collector's dream. 368 pages. Though this was published in 1999, it is in new condition.
Circa: 1999
Condition: Used
Publisher: Charlton Books
Caring For Your Antiques & Collectibles Published 1997
Unused. Still brand new. Caring For Your Antiques & Collectibles from Antique Trader Books, Miriam L. Plans in 1997. Clearly explained instruction guide details how to protect antiques and collectibles from neglect, damage and deterioration. From wood, cloth and tin to leather, brass, plastic and other materials. Step by step instructions. Though this was published in 1997, it is still in new condition. These techniques do not change and will be valuable to this day.
Circa: 1997
Condition: Used
Publisher: Antique Trader Books
Hand Made from Jamaica Bowl
Beautiful 2 1/2 inch tall bowl with a base of little shells, sand and pebbles. Hand painted design and the word, Jamaica, on one side and Handmade etched into the red clay base. Inside is a surprise, fired, drips glaze with blues, greens and browns shining. Though vintage, it has never been used.
Circa: 2005
Condition: Vintage
Manufacturer: Jamaica
Candle Holders
Ganz Snowman Holiday or Winter Candle Holders
Ganz Snowman Candle Holder. 5 3/4 inches Tall x 3 1/2 inches Wide. Fabulous, crackle glaze so that he looks like he's very old. What a happy snowman. We promise he won't melt from the heat of the candle in his back? Still brand New. He will make a wonderful additon to the T Santa and Snowman mug-like T Holders too.
Circa: 2001
Condition: New
Manufacturer: Ganz
Ganz Snowman T Light Holder
Ganz Snowman T Light Holder. At first these little fellows seem like the Ganz version of Royal Doulton type Character Jugs and mugs. They are wonderful little Candle Holders. How cute are these? Use this frame to purchase the one Snowman T Holder. EX13104. Even though these were manufactured and discontinued in 2007, they are still new and in mint Condition. Fantastic gifts for co-workers, friends, relatives. They could even be used as part of a table-setting as place-card holders. ...
Circa: 2007
Condition: New
Manufacturer: Ganz
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Electronic funds exchanges are some of the numerous valuable services which might be provided by your neighborhood financial institution to save you time. Sadly, a number of people don't even know regardless of whether their bank delivers this particular service. If you've ever thought about no matter if electronic funds transfers may be of use to you or exactly how these transfers function, then this article is intended to give you a concise review of the procedure.
Before you can determine whether electronic resources transfers might be useful to suit your needs, it's vital that you recognize what exactly they may be. Whenever you transfer funds electronically, you're basically deducting a particular amount of cash out of your price savings or chequeing bank account and placing it into one more profile. This account can be another accounts which you own, or it might be your account of an individual that you know or are obligated to pay cash to.
Naturally, the explanation earlier mentioned can be a fairly simple model of what occurs when you will make electronic cash moves. The specific method is a little more complex, however not really everything that challenging. When you authorize a transfer out of your chequeing or bank account, the teller at the bank will start the transfer process. The pc method that contains each of the bank's account information and facts will get in touch with the program with the financial institution which contains the account how the cash is becoming moved to, unless the acquiring profile is kept with the exact same bank whereby it would basically entry the account under consideration.
It is going to then approach a drawback from your profile, and either deliver discover of an electronic put in on the other banking institution system or post the down payment towards the accounts straight if both balances are at that bank. Oftentimes the moved money will be registered and readily available right away, even though depending on lender coverage there might be a positioning period of time before the funds are transferred and available.Electronic cash exchanges have a variety of makes use of to put the requirements of financial clients. These moves could be used to send out cash to good friends or loved ones, they can permit you to relocate money from your credit accounts to a different without having to actually withdraw the cash under consideration and redeposit it, and in some cases they can also be employed to make ACH processors on personal loans, charge cards, and a variety of other bills and tools. Take into account your requirements and explore it with an associated with your lender so that you can decide if exchanges can be purchased and when they might suit your uses.

subset: commoncrawl


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Special Introductory Discount for my book:
- Dreaming of Sailing and Making It Happen: Warm Sea
Tales of our cruising life in the Mediterranean is available as an ebook through Smashwords:
Special price $2.99, vs regular price $6.99. Please use promotion code EG63X. Offer valid until April 15, 2014. I would appreciate your feedback comments, please provide them at Smashwords' website.


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Behind The Scoreboard
The emergence of Dak Prescott will go down in history as one of the most surprising storylines of the 2016 NFL season.
Let's rewind. At Mississippi State, Rayne Dakota "Dak" Prescott proved himself to be an excellent college quarterback in 2014. Prescott broke all sorts of school records (4,435 yards of total offense, 27 touchdown passes with 61.6 completion percentages). He was named a finalist for the Maxwell, Davey O'Brien, Manning, and Johnny Unitas Golden Arm awards. In his first season as a full-time starter in 2014, Dak led the Bulldogs to a 10-3 regular season record, its first No. 1 ranking in program history, and led them to the Orange Bowl. The two-time (2014, 2015) first team All-SEC pick ended up with 38 school records. He won the Senior Class Award as the top scholar-athlete on and off the field.
Fast forward – this young quarterback has gone from a third-string rookie taken in the fourth-round pick to the starter on arguably the best team in the NFL, the Dallas Cowboys.
Prescott was not the Cowboys' first choice in the draft. Jerry Jones tried twice to trade up for other quarterbacks but was unable to get the deals done. In all, seven quarterbacks were taken in the 2016 NFL Draft before Prescott's name was called with the 135th pick.
So, how is Dak Prescott doing in his early career in the NFL? During the preseason, the Cowboys' coaches noticed how good the rookie looked in the relief of Tony Romo. One of the coaches went on to say that "Romo's injury would offer a rare chance for a rookie to get first-team reps." The coaches thought maybe Dak could be Romo's primary back-up. But Romo was hurt again. The Cowboys' officials weren't talking about life after Romo in late August but they were certainly thinking about it.
It is November 15 and now it's official.
Romo is healed after suffering a compression fracture in his back and he's ready to return. But only one problem, the kid (Prescott) has not let up. Prescott has led the Cowboys to an 8-1 record and first place in the NFC East.
After Dak and Ezekiel Elliott orchestrated a stunning comeback victory in Pittsburgh, Jones said, "Romo would be Prescott's back-up upon his return to the active roster."
And besides, Prescott is playing too well for the team to make any changes this late into the season.
But all the while, Dak would always say "this is Tony's team. I knew that going into the situation. I think everybody knew that. I'm just trying to do the best I can to give my team a chance to win week in and week out."
Here are some excerpts from the heartfelt speech Romo gave to concede the job to Dak.
"He's earned the right to be our quarterback, Romo said. "As hard as that is for me to say, he's earned that right. He's guided our team to an 8-1 record, and that's hard to do."
He continued, "I was that kid once, stepping in, having to prove myself. I remember the feeling like it was yesterday. It really is an incredible time in your life. And if I remember one thing from back then, it's the people who helped me along when I was young."
"And if I can be that to Dak, you know, I've tried to be and I will be going forward. We all know something magical is happening to our team. I'm not going to allow this situation to negatively affect Dak or this football team by becoming a constant distraction. I think Dak knows that I have his back. And I think I know that he has mine. Ultimately, it's about the team. It's what we've preached our entire lives."


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Lisa using Sew Many Cards
Annika using wink, wink, ink
Jo using Sew Many Cards
All simply stunning~
All the samples are gorgeous but I think my favorite is the hippo by Lisa! She is just adorable I LOVE how Lisa coloured her! Both of the cards on my post are digi's so both are entered.
Hi Ladies,
I am so sorry that I have not gotten by here. I have been very busy putting a new team together, and have desperately been playing catch up.
All the cards look fabulous, and I thank you so much for having Digi Doodle Shop back as your sponsor.


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Picture credit: ktylerconk
Last Monday night I was sitting by the fire in a cosy pub.
Soon I was unable to catch my breath.
The two funny blokes I'd met in an earlier biz meeting - one with a long, odd looking face, the other in a conspicuously fashionable suit - had got me laughing so hard it was painful.
I'd been feeling crappy with a shockingly snotty cold and hadn't wanted to go out.
But I had to.
A colleague had arranged that biz meeting and it was important.
So running into those two blokes for a few beers, great conversation, and a good laugh was an unexpected pleasure, the best kind.
Two days later, I was at a funeral.
I was expecting the occasion to be solemn but it was a joyful celebration of a life well-lived.
I got chatting with a rectangular shaped fella with hairy hands. I imagined his feet were even more woolly, just like Bilbo Baggins'. Anyway, it turned out he was someone I'd met already: thirteen years ago when I was a reporter I'd interviewed him about his first film.
Now, he wants to help me with a project I've got coming up. Despite his hairy hands, I reckon he might just be what it needs.
Two separate occasions. Two "domino effects".
Who knows where those relationships will lead? What effects will they cause?
I've no idea, but they seem positive.
Picture credit: kooklanekookla
Now imagine what can happen when we put this "domino effect" on acid!
Well ya know that's what happens every day when we talk to people online?
Our digital connectedness amplifies the possibility of creating massive waves of "effects" from the "causes" we initiate. So, instead of one face-to-face conversation with someone at a party, on social networks our conversation could be seen (or heard) by thousands of people.
Imagine the knock-on effects.
Mind blowing.
That thing we do, when we put ourselves "out there" could be just the thing someone else "out there" needs. And what's more, they might want to pay us money for that thing we do, or spread it to hundreds of people, or help us in some way.
The idea isn't as difficult to grasp as say, organic chemistry, but it's just as important.
Remember, there are things that absolutely CAN'T happen UNLESS we feel the fear, and PUT OURSELVES and our IDEAS "OUT THERE" anyway.
So we won't change the world for the better UNLESS we take risks and set in motion positive "domino effects".
That's why this stuff matters.
So there's a thing going on here: one thing sets another in motion, and another, and ..........
.....and through the "domino effect" one might stumble upon something unexpectedly good: that's serendipity!
This morning, Gemma Went, of Red Cube Marketing shared a good post by Adam Cohen called "Return on Serendipity". In it he quotes John Hagel who says individuals and businesses "can increase the opportunity to achieve serendipity. Whats your serendipity strategy?" .
Worth thinking about?
There are more ideas too in this post from Rachel Happe: 5 Ways to Orchestrate Serendipity.
For me, it's just about enjoying the potential and possibility of mutually beneficial relationships. They come from connecting with all kinds of good people, to help each other make a positive difference in the world.
That's it.
And who knows what good stuff's about to happen when we put ourselves "out there"?
Love hearing your thoughts. And by leaving a comment here, you might get some surprising new friends (I think Warren Buffet and Lady Gaga read ReallygoodThinking too ya know!). See ya in the comments. Much love, Ian.
Your comments:
04/08/2011 12:46:49
Just come across your work via domino effect from Helen Milligan's twitter feed, to your seminar in Newcastle to this site. Do you have any basic info on the basics of social media connectedness? I'm trying to build a consultancy service which helps Public Sector and Third Sector organisations and could do with some advice!
WHO'S LOOKING FOR WHAT?Energy Business Kindness Purpose Sustainability Running Giving Video Simplicity Community Work Believe Happiness Helping Design Arts Shift Happens Giveacrapanomics Friends Ideas Twitter Passion Brain Guest professor Success Grateful Real Love Happy Lifestyle Meaning Art Connectedness Caring What matters Goals Thinking Learning Creativity World-changing TV Gratitude Clarity Friendship Digital Books Fun Creative Friends Career @ianaspin Suck Aspin's Juicy Brain
- Location: Lancaster Lake District, UK
- Bio: I'm passionate about my work:TV journalist, producer, presenter, business ideas person. I care about: family, friends, helping people, finding meaning, running


text: The Palestinian artist Khaled Jarrar's exhibition at the Whitebox Art Center in New York opens in a few days time. He also has work showing at the Here and Elsewhere exhibition at the New Museum, which is a look at contemporary Arab art from around the world. He won't be attending either exhibition as the racist overlords in Israel referred to him as garbage and refused to let him through to catch his plane. With how the belligerent criminal Israeli regime is behaving right now, the artist was probably lucky to walk away from his prison gate with his life.Continue Reading


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So here is "Sataurday's post"...
Workstations Part 2:
The Writing Workstation
This is my favorite workstation. I think so much creativity happens in this workstation. The kids seem to enjoy it too! I try to change it up every once in a while, but it doesn't change as often as some of the others, I mean if it's working, go with it! Right!?!
Here is the set up:
I have this long row of double shelves in my room. They hold a ton of materials including two workstations. The writing workstation consists of the green lap bench (a bargain at the craft store), the green basket, two binders and various supplies...
|dry erase markers, pencils, crayons
|journals :)
When the kiddos go to this workstation they have the option of completing up to three tasks. I always say up to, because there is always a kid who wants to spend the whole time on one story, and that perfectly OK with me!
Their first option is the label it binders:
I saw this fabulous idea over at First Grade Blue Skies and thought it worked perfectly in this workstation. They are getting the opportunity to write and read, love it! I have a few different binders that I rotate in and out to keep the activity fresh. They would spend the whole time doing this, but I limit them to three label it pages, and then they have to write in the journal. Some choose not to label at all, that's fine too!
Their other options are in the green basket: sequence story or roll a story.
When they use the sequence cards they practice writing a first, then, next, last story in the journal. I got the cards from Lakeshore Learning. They have easy to understand pictures and are color and number coded for easy organization. I keep four sets in the basket at a time and change them every month.
When they use the roll a story dice, they can roll two or three dice. Then they write a story about or including the things on the dice they rolled. Some of the stories can be pretty creative, while other stick to the basics. To make the dice I bought 6 cubes at the craft store, printed out clip art and modge-podged away :)I have six dice and have changed them three times this year. Since the possibility of rolls are great, there is less of a need to change this activity... something I really enjoy!
And that's it! The writing workstation! It is one that is low maintenance, which in a classroom with centers, math tubs and workstations, low maintenance is always a plus!
SO what do you do in your writing workstation? New ideas are always welcomed!
oh... and I'll try to be better with my schedule! The days just seem to get away....


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- Research article
- Open Access
- Open Peer Review
MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells
- Lihua Zhang†1Email author,
- Xueqing Wang†1 and
- Pingsheng Chen2
© Zhang et al.; licensee BioMed Central Ltd. 2013
- Received: 22 February 2013
- Accepted: 5 June 2013
- Published: 14 June 2013
Our previous studies showed that SIRT1 was over-expressed in gastric cancer specimens and related with lymph node metastasis. However, the mechanism of SIRT1 up-regulation and its association with metastasis in gastric cancer remain unclear. The present study was undertaken to understand the role of microRNA in regulation of SIRT1 in the progression of gastric cancer.
Expression of miR-204 and SIRT1 was assessed in two gastric cancer cell lines and 24 matched cancer specimens. Luciferase reporter assay was carried to verify that miR-204 targeting SIRT1. Cell invasion ability of AGS and BGC was detected by transwell invasion assay. Annexin V/PI assay was used to investigate the cell sensitivity of anoikis. Western blot analysis to assess SIRT1, Vimentin, E-Cadherin, LKB1, and β-actin expression was performed in gastic cancer cell lines.
SIRT1 was defined as the target gene and elucidated the biological functions of miR-204 with a luciferase reporter assay and Western blot analysis. We verified that miR-204 levels were down-regulated and significantly associated with the up-regulation of SIRT1 mRNA levels in gastric cancer specimens. Over-expression of miR-204 reduced cell invasion and anoikis resistance in gastric cancer cells. Up-regulation of miR-204 influenced the levels of the epithelial mesenchymal transition (EMT)-associated genes, increasing E-cadherin levels and decreasing Vimentin levels. We demonstrated that the regulation of EMT by miR-204 involves cooperation with LKB1. Furthermore, silencing of SIRT1 phenocopied the effects of miR-204 in gastric cancer cells. These data demonstrate that miR-204 plays an important role in regulating metastasis of gastric cancer, which is involved in post-transcriptional repression of SIRT1.
Our results suggest that down-regulation of miR-204 promotes gastric cancer cell invasion by activating the SIRT1-LKB1 pathway. These data demonstrate that miR-204 plays an important role in regulating metastasis of gastric cancer, which is involved in post-transcriptional repression of SIRT1.
- Gastric Cancer
- Epithelial Mesenchymal Transition
- Gastric Cancer Cell
- Gastric Cancer Cell Line
- Gastric Cancer Tissue
Gastric cancer is among the most common malignancies in East Asian counties [1, 2]. Recurrence and metastasis are the biggest obstacles for the treatment of gastric cancer [3]. Therefore, the search for new therapeutic targets to prevent the metastasis of gastric cancer is an urgent issue. However, the pathogenesis and mechanism underlying the metastasis process remain poorly understood. Epithelial-mesenchymal transition (EMT) is a key step toward cancer metastasis. Loss of E-cadherin expression is a hallmark of the EMT process and is likely required for enhanced tumor cell motility [4, 5]. Epithelial cells lose epithelial characteristics and acquire mesenchymal characteristics by the down-regulation of E-cadherin [6].
Increasing evidence suggests that post-transcriptional regulation of gene expression, which is mediated by microRNAs (miRNAs), controls tumorigenesis and cancer metastasis [7–9]. Both the over-expression of oncogenic miRNAs and the decreased expression of tumor suppressor miRNAs play pivotal roles in cancer metastasis. Adam et al. demonstrated that miR-200 regulated EMT in bladder cancer cells and reversed resistance to epidermal growth factor receptor (EGFR) therapy [7]. This group also showed that the stable expression of miR-200 in mesenchymal UMUC3 cells increased E-cadherin levels; decreased protein expression of ZEB1, ZEB2, and ERRFI-1; decreased cell migration; and increased sensitivity to EGFR-blocking agents. Tie et al. described the regulation and function of miR-218 in gastric cancer metastasis. Decreased miR-218 levels eliminated Robo1 repression, which activated the Slit-Robo1 pathway through the interaction between Robo1 and Slit2 to trigger tumor metastasis [10].
In the current study, we investigated the role of miR-204 in gastric cancer metastasis. We demonstrated that the miR-204 expression was down-regulated in gastric cancer tissues and confirmed that the SIRT1 gene is the direct target of miR-204. Restoration of miR-204 or the knockdown of SIRT1 in metastatic gastric cancer cells induces a shift toward an epithelial morphology concomitant with increased expression of E-cadherin and decreased expression of Vimentin. Down-regulation of miR-204 inactivated LKB1 through SIRT1 to promote human gastric cancer cell invasion.
Cell lines and clinical samples
The AGS and BGC gastric cancer cell lines used in this study were cultured at 37°C in 5% CO2 and 95% air. All cells were grown in Dulbecco's modified Eagle's medium (Invitrogen, California, USA) supplemented with 1 mmol/L L-glutamine, 10% fetal bovine serum (Life Technologies, Inc., Burlington, Canada), penicillin G 100 U/mL, and streptomycin 100 mg/mL.
The Ethics Review Board of Zhongda Hospital, Southeast University Nanjing, China, approved this study. Informed consent was obtained from all patients. We studied gastric cancer specimens (cancer lesions and adjacent non-tumor mucosa) from 24 patients who had undergone resection at the Zhongda Hospital, Southeast University between 2005 and 2010. We gathered all samples in the same manner; they were snap-frozen immediately in liquid nitrogen and stored at −80°C until RNA extraction could be performed. All tissue specimens were evaluated pathologically. No patients had received irradiation or cancer chemotherapy prior to resection.
RT-PCR and real-time RT-PCR
Total cellular RNA was extracted using Trizol (Invitrogen, California, USA). For mRNA detection, SIRT1, E-Cadherin, Vimentin and GAPDH mRNA expression were analyzed by the Sybr Green qRT-PCR according to the manufacturer's instructions (Applied Biosystems).
For miRNA detection, polyA tail was added to RNase-free DNase digested total RNA using the E.coli polyA polymerase (NEB). Two micrograms of the tailed total RNA was reverse transcribed with ImProm-II (Promega). Conventional PCR or Sybr Green qRT-PCR was used to assay miRNA expression with the specific forward primers and the universal reverse primer complementary to the anchor primer. Anchor RT primer was used as the template for negative control and U6 as internal control.
Sequence of RT-Primers
miR-138 F
miR-155 F
miR-181a F
miR-181b F
miR-181c F
miR-181d F
miR-30a F
miR-30b F
mIR-30c F
miR-30d F
miR-30e F
miR-204 F
miR-211 F
miR-9 F
miR-135a F
miR-135b F
miR-133a F
miR-133b F
miR-22 F
miR-199a F
miR-199b F
miR-128 F
miR-217 F
miR-200a F
miR-141 F
miR-34a F
Anchor RT primer
Universal rev primer
E-Cadherin F
E-Cadherin T
Vimentin F
Vimentin T
Luciferase reporter assay
Using Lipofectamine 2000 (Invitrogen), HEK293 cells (104 cells/well) were plated in a 24-well plate. The cells were then co-transfected with 20 mM of either miR-204 or microRNA control, 40 ng of either pGL3-promoter-SIRT1-3'UTR-WT or pGL3-promoter-SIRT1-3'UTR-MUT, and 4 ng of pRL-TK (Promega, Madison, WI). HEK293 cells were collected 24 hours after transfection and analyzed using the Dual-Luciferase Reporter Assay System (Promega). The pRL-TK vector responsible for the constitutive expression of Renilla luciferase (Promega) was co-transfected as an internal control to correct for differences in both transfection and harvest efficiencies. Transfections were performed in triplicate and repeated at least three times in separate experiments.
Western blot analysis and antibodies
Western blot analysis to assess SIRT1, Vimentin, E-Cadherin, LKB1, and β-actin expression was performed as previously described [11]. All of these primary antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, Daly City, CA).
In vitro cell invasion assay
For transwell invasion assays, 1×105 cells were placed on the non-coated membrane in the top chamber (CytoSelectTM 24 Well Cell Migration and Invasion Assay Combo Kit, 8-μm, CBA100-C, Cell Biolab, United States). Cells were plated in medium without serum. Medium supplemented with serum was used as a chemo-attractant in the lower chamber. The cells were incubated for 24 hours; cells that did not invade through the pores were removed using a cotton swab. Cells on the lower surface of the membrane were fixed with methanol and stained with crystal violet (Fisher Scientific Co., Fairlawn, NJ). The cell numbers were determined by counting the penetrating cells under a microscope at 200 magnification in random fields in each well. Each experiment was performed in triplicate.
Anoikis assay
Poly-hydroxyethyl methacrylate (poly-HEMA, Sigma- Aldrich) was reconstituted in 95% ethanol to a concentration of 12 mg/mL. To prepare poly-HEMA coated plates, 0.5 mL of 12 mg/mL solution was added to each well of a 24-well plate and allowed to dry overnight in a laminar flow tissue culture hood. Cells were transfected as before. Twenty-four hours after transfection, 50,000 cells were plated in triplicate in poly-HEMA coated 24-well plates using regular culture medium. Following the addition to poly-HEMA coated plates, cells were collected at 2, 4, 8, 24 and 48 hrs post plating. Cell apoptosis was assayed by Annexin FITC/PI staining following manufacturer instructions (Invitrogen, California, USA). Briefly, cells were collected and washed in cold PBS. Cells were incubated for 15 min at room temperature in the presence of 1 μl Annexin V-FITC, 1 μl of propidium iodide and 98 μl of 1x binding buffer (all reagents provided by the manufacturer). After incubation, 400 μl of 1X binding buffer was added to each tube, and cells were analyzed by flow cytometry.
Databases and statistics
We computationally screened target genes of miR-204 with the Target Scan program (http://www.targetscan.org/index.html), PicTar (http://pictar.bio.nyu.edu/), miRanda (http://www.microrna.org/microrna/home.do), miRBase (http://microrna.sanger.ac.uk) and microRNAMap (http://mirnamap.mbc.nctu.edu.tw).
We used the paired Wilcoxon nonparametric test to analyze pairs of non-tumor mucosa and cancer samples. The statistical significance of intergroup differences was determined using the χ2 test. All statistical analyses were performed using SPSS 16.0 software (SPSS, Chicago, IL). Differences were considered significant if P < 0.05. All experiments were performed in triplicate and repeated at least three times.
Expression of miR-204 is significantly down-regulated in gastric cancer and associated with cancer metastasis
Correlation between miR-204 expression and SIRT1 mRNA expression in 24 gastric carcinomas
miR-204 expression
Case number
SIRT1 mRNA expression
Interaction of miR-204 with the 3'UTR of SIRT1 mRNA
To determine whether miR-204 can affect endogenous SIRT1 expression, we examined the effect of miR-204 activation on SIRT1 in AGS and BCG cells. Real-time PCR and Western blots revealed significantly decreased expression of both SIRT1 mRNA and protein in GCCs transfected by miR-204 mimics (Figure 3C & D). These results indicate a negative role for miR-204 in the regulation of SIRT1 expression.
Over-expression of miR-204 and down regulation of SIRT1 induces an mesenchymal -to- epithelial transition phenotype
Over-expression of miR-204 and knock-down of SIRT1 inhibit gastric cancer cell metastasis
Restoration of miR-204 and down-regulation of SIRT1 mediate suppression of anoikis resistance
Down-regulation of miR-204 promotes cancer cell invasion by activating LKB1 through SIRT1
Class III histone deacetylase SIRT1 blocks senescence and apoptosis and promotes cell growth and angiogenesis, making it a critical regulator of tumor initiation, prognosis and drug resistance. Our previous studies have suggested that the up-regulation of SIRT1 is related to lymph node metastasis in gastric cancer [12]. The underlying mechanism by which this occurs is still unclear. There are 34 miRNAs are predicted to target the 3'UTR of SIRT1, which is 1.7 kb. We evaluated and analyzed the expression of these miRNAs that are conserved across various species in normal gastric mucosa tissue, gastric cancer specimens, and 2 gastric cancer cell lines. The results showed that reduced expression of miR-204 frequently occurred in gastric cancer tissues and was related with the up-regulation of SIRT1. We also verified this result in 24 gastric cancer tissues and found that the decreased expression of miR-204 was related with cancer metastasis.
miRNAs are involved in several important biological events such as tumorigenesis and cancer metastasis. miRNAs are known to act as regulators in gastric cancer cell growth and to regulate gastric cancer metastasis. Deregulation of some miRNAs, including miR-101, miR-107, miR-221, and miR-222, has been observed in gastric cancer [13–15]. miR-101 was down-regulated in gastric cancer tissues. The ectopic expression of miR-101 significantly inhibited cellular proliferation, migration, and invasion of gastric cancer cells by targeting EZH2, Cox-2, Mcl-1, and Fos. miR-107 is frequently up-regulated in gastric cancers, and its overexpression is significantly associated with gastric cancer metastasis. Here, we demonstrated miR-204, another miRNA specific to gastric cancer metastasis, and its specific target, SIRT1.
Epithelial–mesenchymal transition (EMT) consists of a rapid and often reversible change of cell phenotype [16]. Epithelial cells loosen cell–cell adhesion structures, including adherens junctions and desmosomes, to modulate their polarity and rearrange their cytoskeleton. Specifically, intermediate filaments typically switch from cytokeratins to Vimentin [17, 18]. Cells become isolated, motile and resistant to apoptosis. Many genes and pathways have been implicated in inducing EMT in tumor cells. Typically, these pathways are also active in other processes, including cell proliferation, apoptosis and differentiation during early developmental stages, tissue morphogenesis and wound healing. Their specific role during human tumor progression is usually not well understood [19]. Our previous analysis of the clinical characteristics indicated that SIRT1 expression was significantly associated with tumor stage and the presence of metastasis, which further indicated that SIRT1 acts as a tumor promoter and facilitates the infiltration of gastric cancer. The oncogenic epithelial-to-mesenchymal transition (EMT) is thought to play an important role in tumor progression. Our current results suggest that miR-204 down-regulation and SIRT1 restoration can induce EMT in GC cells.
There is a tight correlation between anoikis resistance and oncogenic EMT [20–22]. A common hallmark of EMT is the breakdown of E-cadherin expression or function [23], which suffices to circumvent anoikis in some contexts. For example, the targeted knockout of the E-cadherin gene in a mouse mammary tumor model or the stable knockdown of E-cadherin in a mammary epithelial cell line confers anoikis resistance [24]. This finding implies that EMT-promoting transcription factors such as ZEB1/2, Snail1/2 and Twist can block anoikis both by directly regulating apoptosis control genes and by suppressing E-cadherin expression. Here, we discuss the mechanism by which E-cadherin suppression triggers signaling events that control other apoptosis regulatory genes [25]. This study also investigated whether the miR-204-SIRT1 pathway was involved in anoikis resistance and metastasis promotion in GC cells. We demonstrate that miR-204 down-regulation and SIRT1 overexpression both can induce anoikis resistance in GC cells.
LKB1 was identified originally as the tumor suppressor gene on human chromosome 19p13. LKB1 inactivation triggers EMT in lung cancer cells through the induction of ZEB1 [26]. Cheng et al. reported that LKB1 was an essential upstream regulator of p53-mediated anoikis [27]. Recent studies have revealed that many proteins, such as SIRT1, are involved in the regulation of LKB1 [28]. Over-expression of LKB1 promoted cellular senescence and retarded endothelial proliferation, which could be blocked by increasing SIRT1 levels. Knocking down of SIRT1 induced senescence and elevated the protein levels of LKB1. SIRT1 antagonized LKB1 activation through promoting deacetylation, ubiquitination and proteasome-mediated degradation of LKB1. Our data show that over-expression of miR-204 increased LKB1 expression in GCCs, while down-regulation of SIRT1 can also restore LKB1 expression in GCCs. LKB1 down-regulation could promote cancer cells invasion even when miR-204 was upregulated. As a result, miR-204 may modulate LKB1 by interacting with SIRT1. These data suggest that reduction of miR-204 promotes EMT by inactivating LKB1, and SIRT1 might be the direct target of miR-204 in the LKB1 pathway.
In conclusion, our data demonstrate that the down-regulation of miR-204 promotes gastric cancer cell metastasis by activating the SIRT1-LKB1 pathway. Therefore, we show that miR-204 is an important regulator in gastric cancer metastasis and suggest the potential application of miR-204 in gastric cancer therapy.
The authors wish to thank Hong Fan for clinical, laboratory and logistic support.
Financial support
This work was supported by grants from the natural science foundation of Jiangsu Province (BK2012750), and the Natural Science Foundation of China (81101856).
Authors' Affiliations
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- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/13/290/prepub
Pre-publication history
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Add trial version for tables and smart phones
I like to support developer of good appliations. That is why I bought your game for Android tablet, but only after pirating it first. If I couldn't pirate it and try it for free, I wouldn't buy it. Now I even recommended it to the teacher of my class. She really likes similar tools for kids.
My point is, that you should add a trial version (maybe first few levels or the first stage) available as a trial. Otherwise you're loosing money, because people won't pay for something they can't try.
Best regards,
your new customer ;-)
We released DragonBox Lite a few days ago, a trial version of our algebra games!


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Corton couldnt be better placed for you to enjoy the very best of Suffolk: both coastal and inland, where the cathedral city of Norwich and the dramatic Norfolk Broads are as close as youd like. The site has a fascinating and unusual history, beginning its recreational status early in the last century as a holiday location dedicated to the civil service. Today, Cortons local attractions, views and traditions of rustic comfort and homeliness still prevail but with an added incentive: a Warner welcome to gladden the heart.
Enjoy a swimming pool, sauna and steam room, a wide range of indoor and outdoor activities like snooker, pool(extra costs apply), short mat bowls and bowls green, putting green and boules. The traditional seaside resort of Corton sits atop a cliff with spectacular views over the sea, with steps down to the beach. Its compact site is prettily landscaped and is a riot of colour in spring and summer.
On a Warner Leisure Hotels short break theres live entertainment every night with breakfast, three course dinner and accommodation all included in the price. Please note all our breaks are for adults only. All members of the party must be over 21 years of age.
Please note that Beauty treatments are available on Thursday and Saturday only
From: £199.00
Get Directions on Google maps
View on:
Google maps (area overview)
Get an Ordnance Survey map covering the Corton area.
Heritage Rated from 1- 5 (low-exceptional) on historic interest
Somerleyton, St Mary's Church - 3.3 miles (Historic Church)
Somerleyton Hall and Gardens - 3.3 miles (Historic House)
Herringfleet, St Margaret's Church - 4.6 miles (Historic Church)
Gisleham, Holy Trinity Church - 5.5 miles (Historic Church)
St Olave's Priory - 5.6 miles (Abbey)
Time and Tide Museum, Great Yarmouth - 6.4 miles (Museum)
Burgh Castle Roman Fort - 6.5 miles (Roman Site)
Great Yarmouth Row Houses and Greyfriars Cloister - 6.5 miles (Historic Building)
Elizabethan House Museum - 6.7 miles (Historic Building)
Berney Arms Windmill - 7.1 miles (Historic Building)
Other Nearby Accommodation
+ Heritage Rating + ?


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I recently read "InBound Marketing" by Dharmesh Shah and Brain Halligan. These guys are the founders of HubSpot. If you have used twitter grader or website grader, you will know what I am talking about.
The book starts off really well and I particularly liked how they classified good content. They used Seth Godin`s term "remarkable" content which means content that is worthy of someones "remarks". This I thought was an amazing and alternate way than to just keep saying "Good Content" or "Original Content". And as you keep thinking of it, it hits the nail squarely on the head about what is the best kind of content writing for SEO.
Most people when starting websites or starting SEO on their websites just start using too much of their competitors ideas and eventually this "remarkable" content concept gets set aside.
Writing original content is the only real basic thing that will get you your SEO results, it is the only guarantee that will get you the conversion points you want and it will make you come out as a thought leader. Read more about why be a thought leader?
Original remarkable content gets shared, it gets appreciated and it makes you come out on top. Just like in the gold rush era, sometimes internet marketing and Seo can be about following others trails and taking a lot of chances because the rewards can be amazing. The tendency is there to just start doing something. But fortunately, unlike the gold rush era, Seo isn`t about actually finding the Gold in Google, the gold is actually already in your website, in your linking ideas, your remarkable content and your care for communication and networking. With these in place, Google will follow you.


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In our fast-paced world, many feel just a bit overwhelmed. West Jefferson's Fitness Center may provide some relief and answers to some of the tension.
Denise Hoffman will conduct another stress seminar in the series, "Stress Management: Not the Same Old Same Old." This one is titled, "The Body's Energy Centers: In Balance, Out of Balance, and Returning to Balance."
Hoffman said, "Ours is an overstimulated and 'living solely in the head' culture and the consequences are felt in the body."
"We will discover, or perhaps rediscover the many ways our bodies speak out to us; moving us back towards balance."
She also said that special emphasis will be given to the energy center of the heart. Light movement and breath work exercises will be included.
Seminar dates are: Aug. 6 from 12 to 1 p.m. in Activity room 2 at the Marrero Fitness Center at 1121 Medical Center Blvd. and Aug. 7 from 7 to 8 p.m. in Activity room 1 at the Oakwood Center at 175 Hector Ave. in Gretna.
Hoffman said that in the fall she and colleague Christine Mamolo will hold water meditation seminars for those who hold memberships at the center.
The stress management seminars are free and pre-registration is required. Contact Denise Hoffman at 504.348.0055, 504.349.6908 or firstname.lastname@example.com for questions or comments.West Jefferson Aquatics Center
Several members of the fitness center are enjoying the multipurpose exercise pool and whirlpool. They are swimming or relaxing in the pool and whirlpool to relieve stress, socialize and forget about the cares of the day.
Many have learned that aquatic exercises can be beneficial for those who participate in low impact aquatic aerobic exercise programs.
Antoinette Alonzo, Donald Robinson, Earl Giszlair and Patricia Calvin-Scott were a few of the members who took advantage of the facility.
Robinson said, "This is a lot of fun; it's very relaxing."
Calvin-Scott said that she likes meeting new people and socializing in a relaxed atmosphere.
There were approximately ten members who enjoyed the bubbles and mild waves of the whirlpool. The chatter and laughter was friendly and jovial.
Individual sixty-minutes swimming lessons are also available for ages sixteen and up. They range from beginner to advanced levels including Triathlon Training, depending on the individual needs of the client.
Interested persons are encouraged to stop by for a free tour of the facility or call 504-348-0055 for more information.
New Dates for West Jefferson Medical Center's Auxiliary Linen Sale
Althea LaCour, a member of the West Jefferson Medical Center Auxiliary announced that the linen sale that was previously scheduled for Aug. 12 and 13 has been rescheduled for Aug. 5, 6 and 7. The sale will be held in the Atrium at the medical center from 7 a.m. to 5 p.m.
National Merit Scholarship Winner
Peyton T. Pertuit has received the National Merit Louisiana State University scholarship according to the July 14, announcement.
Merit officials announced that Pertuit will probably study petroleum Engineering.
He is a graduate of Jesuit High School in New Orleans.
- Northwestern State University's President's List
Chance Creppel made all A's and earned a place on the President's list at Northwestern State University in Natchitoches.
Creppel was one of four hundred and seventy-six students who earned the honor for the 2014 spring semester.
Students are required to earn an A in each course pursued.
Congratulations to Creppel and to all students who are excelling in their studies.
Young Marines Youth Organization
The Young Marines Youth Organization unveiled a new program; "Closing the Gate on Drugs" at their annual Adult Leaders Conference held June 4-7 in Washington D.C.
The American Legion Child Welfare Foundation provided $90,000 in grant money to create printed materials and support, designed to expand the current "Drug Demand Reduction Program" of Young Marines.
The curriculum used is "Project ALERT", a school-based, substance abuse prevention program for grades seven and eight.
Andy Richardson, public relations representative said, "The program focuses on the drugs that our youth are exposed to early and most often." He also said that the word "Gate" refers to what is called "gateway drugs" which are tobacco, marijuana, prescription medication, inhalants and alcohol.
The additional funding will afford each unit of the national organization to expand their resources that enhance the mental, moral, and physical development of its members.
Mike Kessler, national executive director and CEO of the young Marines said, "With our new 'Closing the Gate on Drugs' program, we consider ourselves the premier drug demand reduction youth organization with national scope and impact."
Some readers might remember, Young Marine of the Year Joshua Aikman of Marrero who earned a trip to Washington D.C., Guam and Iwo Jima for his excellent academic and character in the Jefferson Parish Sheriff's Office of Young Marines program. There are units located throughout Louisiana and other states.
The new program consists of lessons that help youth learn and practice new skills and strategies for resisting drugs; in addition the lessons build positive expectations about a life without drugs.
The Young Marines is a national non-profit 501c (3) youth education program and service program for boys and girls ages eight through high school.
To find a unit near you and for more information visit the official website at http://www.youngmarines.com.
Jefferson Cops and Clergy
To all parents, schools, churches and community leaders who want to encourage, and empower the youth of our area, you may want to support the "Jefferson Cops and Clergy Back to School Extravaganza" on Aug. 1.
There will be entertainment, food and fun for youth at the Jefferson Cops and Clergy headquarters at 1425 Walkertown Way in Marrero from 6 p.m. to 9 p.m.
For more information call Ty Allen at 504-255-6985.
Harry S. Truman Middle School
Assistant Principal Terry L. Johnson invites the community to "Meet and Greet" the new Principal of Harry S. Truman Middle School, Mr. Tracy Guillory.
The staff will host the event on Aug. 4 from 5 p.m. to 6:30 p.m. at 5417 Ehret Rd. in Marrero.
Rosalie Simmons writes about people, events and resources in Marrero. Contact her at 504-347-4215 or email@example.com.


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Quarter 1 of the year is completed. Where did it go? Oh well, time to think about this new quarter. My list of goals has grown because I feel like I can get more accomplished this quarter as things are closer to being done. Without further ado here is my list:
1. Baby quilt with Dr. Suess and minky fabric. Everything is cut, all I need to do is put it together, quilt and bind it. To complete the quilt top is my one monthly goal this month, and I hope to get it further along than that. This quilt was intended for an arrival in December.
Here is to a great quarter!
Friday, April 8, 2016
Quarter 2 Finish-A-Long Goals
2 comments:
I hope you do get to make progress on these lovely projects and see many to the finish before too long ☺ I especially like the blue table runner - is it your own design?ReplyDeleteReplies
The blue table runner is from a pattern from Connecting Threads. It was a kit from 2-3 years ago. I do not remember the name off the top of my head. Thank you for the lovely comments. I would love to get them all done, but realistically I hope to get the ones that are very close to completion done.Delete
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I am stuck on the final temple door. I went back through the fire giant fortress and could not find any extra clues. I did go back and clear the rest of the map. I found the cryptic note but can't decipher it completely (I get a little bit of it). (I may not have the appropriate background in computers.) I did check, it is not in standard computer texts.
Could you maybe help me with this a bit.


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tv Newsline WHUT November 8, 2012 7:30am-8:00am EST
7:30 am
party opened their congress to reflect on the past and chart a course for the future. welcome to nhk world "newsline." the nation of 1.3 billion have gathered to take part in a process that is both highly controlled and highly secretive. representatives of the ruling communist party have opened their congress. over the next week, they'll debate, discuss and make deals, and when it's all over, the next generation of leaders will take power. the 18th congress of the chinese communist party opened thursday at the great hall of the people in beijing. the meeting happens every five years. delegates will approve new policies and appoint new party leaders for the five years to come. nhk world's james tengan is our guide to the congress. he joins us from beijing. james? >> reporter: yes, gene, it's a brisk 7 degrees celsius here in beijing, and the city is now
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abuzz that the congress is under way. signs and banners bearing slogans are everywhere. some read "cheers to the great chinese communist party," for without the communist party, there would be no new china. this is a major political event, and authorities carefully orchestrate every detail. i went for a tour of beijing to see what they've done. signs of the congress are everywhere in beijing. flowers, elegant decorations and banners. when i got into a taxi, i found another sign. ahead of the party congress, local authorities here in beijing have instructed all taxis to take the handles off so that people can't open the windows. chinese authorities are trying to prevent activists from throwing antigovernment leaflets out of the windows of moving
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taxis. police in beijing have put strict traffic checks in place for vehicles entering the capital. government authorities have mobilized an army of volunteers to help with security. they say 1.4 million citizens are taking part in the operation. the volunteers are told to keep suspicious people out of the city center. >> translator: i volunteered to help maintain security in the city. we're here to make sure the convention runs smoothly. >> reporter: security gets more intense in the heart of beijing. police squads patrol in and around tiananmen square. people heading into the famous site face three checks, including bag searches. the party convention will be summarizing the past ten years under president hu jintao. in the elaborate building you see behind me, the communist
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party is holding a retrospective exhibition. more than 2,000 photos and documents are on display. the pictures and words stress how president hu and his government struggled to make china better during the last decade of rapid economic growth. >> james, during the last decade, china has changed socially. people spread information through the internet, they question authority and complain about corruption. how would you describe the climate now that the congress is under way? >> reporter: yes, gene, there's a feeling of tension here, of authorities being on heightened alert. government officials are always on edge before, during and after the congress. their number one priority is to make sure the meeting goes off without a hitch. they want no trouble, no disruptions, nothing to take away from this important political transition. and so, they shut things down or
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beef up security to keep it all running smoothly. the congress opened thursday morning in beijing's great hall of the people. it's about a ten-minute drive from our studios. i went there to watch it all unfold. china transformed into a global power during president hu's ten years at the top. it was the world's sixth largest economy. now it's the second largest. >> reporter: we asked nhk world's --
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>> reporter: china has faced diplomatic and domestic challenges over the last decade under president hu jintao's leadership. >> reporter: hu promoted what he called the concept of scientific development. the policy aims to create a harr mounce society. the process required slower growth. the hu administration abolished a tax farmers had to pay based on the size of harvests.
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it was part of the president's effort to narrow the economic gap between urban and rural areas. hu also worked toward a sweeping consolidation of coal mines and chemical plants, which resulted in a reduction in pollution. but the president hasn't been able to control china's income disparity or corruption among its bureaucrats, and so, public anger with the government is simmering. migrant workers in cities and students looking for work are among those who are upset. >> translator: it's so difficult to find a job. >> reporter: hu also faced dissatisfaction ethnic minorities have with the government.
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the riots in 2008 and 2009. on the international front, china under hu used remarkable economic growth to boost its influence. the company hosted the beijing olympics in 2008 and the shanghai expo in 2010. years of economic growth paid off that year. china surpassed japan in gross domestic product to become the world's second largest economy behind the u.s. the chinese government with its growing military started to flex its muscles in the region. it wrangled with asian nations over control of islands in the south china sea and east china sea.
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>> reporter: the congress opened thursday morning in beijing's great hall of the people. it's about a ten-minute drive from our studios. i went there to watch it unfold. 2,300 delegates from across the country gathered inside the great hall of the people. >> reporter: president hu jintao is now in the midst of giving a work report on past achievements and future goals. >> translator: the communist party has united all ethnic groups across the country and led the people. we have also transformed the old, underdeveloped china into a new china that is prospering every day, but we have to realize there is room for improvement in our work. the unbalance of development and the lack of sustainability are still evident. there are many obstacles -- the
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disparity between urban and rural areas is wide, the gap in income distribution remains large, and corruption is still a problem. >> reporter: hu spoke for about 90 minutes. he laid out an economic challenge for china. >> translator: let's work together to double the gross domestic product and the average income and build a moderately prosperous society in all respects by 2020 compared to how things were in 2010. >> reporter: hu took over as the communist party's general secretary in 2002. he is set to lead the top post when the congress ends next wednesday, and vice president xi jinping is set to take over.
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and joining us now is michitaka. you were with me in the great haf hall of the people as president hu was giving his final speech as communist party general secretary. what do you make of his words? >> the most notable part of the speech was when president hu spoke about the concept he supported. he wants to make a scientific argument of development, one of the communist party's guiding principles. it calls for review of the party's economic policy and aims to incorporate sustainable development, which takes into account social welfare and environment, making this concept a guiding principle would be part of hu's legacy. it would give him the same status as leaders past, inclu including dan xioping, and it
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would help him maintain influence within the party after he steps down. he also admitted during his speech china's gap is wide and widening, and he said the communist party would continue its effort to fight corruption. >> translator: all those who violate party discipline and state laws, whoever they are and whatever power or official positions they have must brought to justice without mercy. >> reporter: in some ways, president hu spoke directly to citizens who are fed up with corruption. the party is trying to keep a lead of government movements by addressing public frustration. >> michitaka, what kind of changes are we going to see with the community party's political bureau and its inner leadership, the politburo's standing committee? >> reporter: right. after the congress closes next
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wednesday, president hu would hand over the post of general secretary to vice president xi jinping, for a younger generation. this time around, they have one difference from the past -- there is no so-called strongman pulling the strings. president hu and his predecessor were discovered and backed by dan xioping, so their appointment to the party post were a matter of certainty. xi, however, did not have such a supporter. he rose to the top among a variety of interparty forces. that would make it all the more difficult to choose a new party leadership to support xi, because those forces have conflicting agendas. many names have been marched as possible members of the standing committee. several analysts believe several
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members would be chosen to govern china's population of 1.3 billion and steer the country into the future, but the discussions of the power plays are still going, so we'll keep watching for any details of this secretive process. >> thank you, michitaka. and we'll be following this process every step of the way over the next week. we'll guide you through the issues related to the communist party's congress and china's transition of power. on friday, we'll find out a little more about the men who become the country's top two leaders, who they are and how they got to where they are. so, stay with "newsline." i'm james tengan in beijing. cradle of culture, economic powerhouse.
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many enjoy the fruits of prosperity along the path to a new china, but millions are missing out. at a time growing public discontent, members of the communist party are choosing their new leaders. "newsline" correspondents are reporting from the party's national congress. don't miss our special coverage, "china: the next generation," 8:00 p.m. japan time here on "newsline." trade friction between the eu and china is mounting over alleged unlawful business practices in solar panels. the eu says the chinese government subsidies for its solar industry are giving it an unfair advantage. the european commission has launched an investigation into the practices. the probe was prompted by a complaint filed in september by an eu solar industry association. the commission says it has gathered enough evidence to support the association's case. separately, the commission has been conducting an antidumping
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investigation on solar panel imports from china. china, for its part, has filed a similar complaint against the eu with the world trade organization on tuesday. the country is making a similar accusation about unfair subsidies for eu products. now let's take a look at the markets. european share prices are trading on the back of a grim economic forecast for the eurozone. here's a look at the london ftse index, currently up by 0.25%. frankfurt's dax index also gaining by 0.5%, and the cac 40 in paris gaining 0.4%. earlier, asian stock prices were mostly lower on thursday following an overnight tumble in the u.s. sentiment was weighed down heavily as investors anticipate a fiscal cliff in the u.s. tokyo's nikkei average ended 1.5% lower, extending losses to four days. south korea's kospi lost 1.1%. hong kong shares were down 2.4%.
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looking at currencies, the yen is keeping a firm tone against the dollar and euro. traders are buying safer currencies like the yen due to a cautious outlook for the global economy. the dollar/yen right now 79.81 po 85. the dollar is also lower against the yen, currently 101.75 to 75. many market players are on the sidelines ahead of a european bank central policy meeting later today. some key japanese economic indicators came out on thursday. they all show signs of a slowdown in business activities. the current account surplus for september shrank for first time in two months. this is a broad measure of foreign trade. finance ministry officials say the account surplus stood at $6.3 billion. that's down about 70% in yen terms compared to a year ago. the slide was mainly due to a trade deficit in september. sharp falls in exports to the eu and china are higher. energy imports dragged down by
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the trade balance. the deficit came to about $6 billion. exports amounted to about $64 billion. that's down 10.5%. imports were up 4.5% to $70 billion. the cabinet office officials say workers have become more pessimistic about their businesses. the sentiment index for october dropped for the third straight month. it fell 2.2 points to 39 points. the officials attribute the drop to tense relations with china and the subsequent decline of chinese tourists and japanese exports to china. also taking a toll was a slowdown in auto sales after the end of government subsidies for buyers of eco-friendly cars. the number of corporate bankruptcies in october went up for a second straight month. a private research firm says 961 companies went under with debts of more than 10 million yen. that's up 6% compared to a year ago. the researcher says the worsening performance at leading tv and mobile phone-makers led
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to the failure of smaller enterprises that do business with them. soaring fuel prices also caused some trucking firms to go under. business leaders from japan and the united states are now gathering at an annual conference in tokyo. one japanese executive expressed strong concerns about the global economic outlook. at the start of the 49th conference that opened on thursday, the chairman of the japan business federation, he hiromasa yonekura, spoke before the audience. >> economies are struggling to find their way back to sustainable growth while grappling with so indebt problems. >> yonekura noted that the economies of china and other emerging nations are slowing down. they had up to now made a key contribution toward global growth. during the two-day meet 'the delegates will discuss various issues. they include energy and financial problems as well as the multilateral free trade talks under the trans-pacific
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partnership agreement. they will compile a joint statement on friday. here's more of the latest market figures. opposition troops in syria are setting their sights on key targets in the capital damascus. rebels say they fired mortars at president bashar al assad's palace. [ shots ] state-run media contradicted the rebels' account and said opposition troops fired on residential areas in what it called a terrorist attack.
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it said at least three people were killed. a day earlier, rebels set off a car bomb near the presidential palace. at least 11 people, including pro-government militiamen, died. opposition forces are reportedly bringing in fighters from other parts of syria to focus on damascus. human rights activists say fighting around the country killed more than 200 people on tuesday alone. the american maker of an anti-islamic film has been sentenced to one year in prison for violating the terms of his probation on a separate charge. the film sparked outrage throughout the muslim world. a u.s. court on wednesday handed down a ruling on the 55-year-old california resident. the man was on probation after being convicted of bank fraud but was again detained in september on suspicion of using false identities and breeaching the terms of his release. he was behind the production of a film that muslims said
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insulted the prophet muhammad. a posting of the film angered muslims around the world. the pakistani cabinet minister has placed a $100,000 bounty on the filmmaker, and some are expressing concern that the man could be harmed by those angered by the video. conventional arms are well known for causing far more real harm than weapons of mass destruction, but there is still no accepted international treaty to restrict the trade in items such as guns and tanks. that's why the united nations decided on wednesday to resume negotiations next march into finally regulating the global arms trade. the previous round of talks broke down in july due to disagreements over which categories of weapons would be covered. japan and other supporters of the current draft treaty argue that conventional arms produce more casualties than weapons of mass destruction. they're aiming to get the regulations approved during the upcoming negotiations. many people living in the northeastern united states are
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saying not again. an early dose of winter weather has walloped their region just as it's recovering from the impact of last week's monster storm sandy. this latest storm brought snow, rain and wild winds, making streets and sidewalks slick and making getting around slow. the weather forced airlines to cancel more than 600 flights in and out of the northeast. >> the national weather service warns that there could be some major flooding in spots already eroded by sandy. >> new york mayor michael bloomberg says the storm would not be a big problem under normal circumstances, but sandy damaged coastal areas, so he called on residents there to evacuate as a precaution. it's making life even more difficult for thousands of people. sandy killed more than 40 people in new york city alone. it triggered flooding and power outages. 30,000 households in the city are still without electricity.
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all of this may be easing. meteorologist robert speta has more on that. robert? >> that's right. actually, across new york, you know, people are waking up here to some clearing skies as that nor'easter continues to rush off there to the northeast, but already seeing that snowfall, these gusty winds near the coastline, actually in man tuckett and massachusetts. you saw a report of 84-kilometer-per-hour winds. great news, everything is easing off. unfortunately for portions of new england, as the system continues to push off, you could still be seeing 10 to 30 centimeters of additional snow out heerks and it's that wet type of snow, so driving in and around the northeast throughout the next several days, until all that mets or clears off, technician going to be rather slippery and dangerous at time, so slow down on the roads. but let's look at the other side of the country. we have another storm system in and around idaho, montana. this one's just as potent. actually, upwards of about 20 to 30 centimeters is going to be seen across this area and in some isolated locations in the mountain passes, nearly 90 centimeters. that's almost a meter of snow
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that's going to be expected over the next several days in and across this region. if you're a skier, you definitely will be enjoying it, but for the general population, it's going to be some dangerous weather accompanied by nearly 72-kilometer-per-hour winds creating that windchill, so frostbite will be a major factor. talking about cold temperatures, see all the areas in blue diving towards the south? those are freezing temperatures. winnipeg, a high of 2 on your thursday, denver is going to be getting up to 19, and as we look off towards the northeast behind that nor'easter, new york only getting into the single digits as we go throughout thursday. let's take a look over towards europe, though, into the uk. we're watching a low pressure area push through. that's going to bring some rain showers across the northern portions of the uk first and then moving down to the south, all across the british isles, as that system starts to move in, especially on friday. it's going to be a wet one here. meanwhile, into portugal and spain, a low pressure area's been lingering here for several days now, and over the course of several days, as that rain continues to pile on, that ground becomes saturated, thus, flooding is going to be high risk and even mud slides in and
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across that area. similar conditions expected into turkey due to a very potent and strong storm system moving through there. now, eastern europe, you're going to be seeing some single-digit temperatures, stockholm only getting up to 1 here for your high. while into the west, a pair of 12s there for london and paris going through your thursday. let's take a look at eastern asia, though. we're watching a storm system develop here in china. that's pushing off towards the east, expected to bring some rain showers actually to korea on saturday and eventually into sunday across japan, as this continues to develop and pushes off. meanwhile, we also have a winter storm system coming out of mongolia. that's going to bring some near freezing temperatures into beijing, accompanied by some blowing snow, possibly in and across this area. you could be seeing blizzard-like conditions across northern portions of china, but good news, at least for the next several days in japan, some fair weather is expected. actually, in hokkaido, we've been watching the storm system. that's slowly starting to taper off, even into northern japan, also have this rough weather. i want to show you a video coming out of sendai here after
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some of these storms. that's one of these beautiful pieces of nature here. we had a rainbow coming across the sky. remember, sendai is one of those areas that was hit significantly by last year's tsunami, so i'm sure this was a welcome sign of relief after the storms today. but let's take a look at the temperatures across asia here, including tokyo, getting up into the high teens on our friday. look over towards the west, though, beijing with a high of 11. in ulan bator, not getting up to the freezing mark, minus 3 will be your high to start off your weekend. let's take a look at your extended forecast.
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Архив за November, 2009
Dallas Symphony Orchestra – «Alexander Nevsky»
Sounds that kept provoking smells and colors: Thursday was synesthesia night at the Dallas Symphony Orchestra. Prokofiev's cantata based on his score for
Posted: 28.11.2009 under Newsbreak.
Комментарии: нет
Macedonian Philharmonic celebrates 65th anniversary
Concert of the Macedonian Philharmonic in the Army Hall on Thursday evening marks the 65th anniversary from its establishment.
Posted: 27.11.2009 under Dates of classical music.
Комментарии: нет
Valda Wilson sings opera's praises
Australian soprano Valda Wilson talks about her meteoric rise to operatic acclaim, plus win tickets to see Riverside Opera's production of The Elixir of Love and a Taylors of Harrogate coffee set.
Posted: 27.11.2009 under Newsbreak.
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William Preucil will give recital
The Department of Music at Ashland University has scheduled a guest artist recital featuring William Preucil, violinist and concertmaster for the Cleveland Orchestra
Posted: 27.11.2009 under Artist Recitals.
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John Adams is feeling festive
John Adams sits in the audience during rehearsal with the Berkeley Symphony at Zellerbach Hall at UC Berkeley on Oct. 14.
Posted: 27.11.2009 under Festivals.
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Perspiration — but don't forget inspiration
Dizzy Gillespie helped to set Alison Balsom on a career path as a classical trumpet soloist — if not in person, then at least in spirit.
Posted: 27.11.2009 under Classical Competitions and Awards.
Комментарии: нет
FCC approves WGBH purchase of radio station
The Federal Communications Commission approved today WGBH's purchase of classical music radio station WCRB-FM (99.5) from Nassau Broadcasting
Posted: 26.11.2009 under New media.
Комментарии: 1
Listel's: Legendary producer Steven Epstein
One of the most influential pairs of ears in the recording industry belongs to Steven Epstein. The veteran producer's name isn't as famous as those
Posted: 26.11.2009 under Music magazines.
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Perform at Royal Concert Hall
BBC's Last Choir Standing winners Only Men Aloud will perform in Glasgow next week. The Welsh choir are back with a very special Christmas-themed tour
Posted: 26.11.2009 under Concert halls.
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Alfred Brendel Gives Master Class
Alfred Brendel is classical-music royalty. He is a pianist who burst onto the scene in the late 1950s and who has since maintained his own identifiable sound
Posted: 26.11.2009 under Master-classes.
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A motorcyclist sustained serious injuries during a collision on the A45 between Raunds and the A14.
The collision took place at about 3pm on Sunday (May 28) and involved the motorcyclist and two cars.
A police spokesman said: "The 47-year-old man riding the motorbike was taken to hospital with serious injuries.
"Nobody else was injured."
Officers would like to speak to anyone who may have witnessed this collision or who may have any information about it.
Anyone with information or who witnessed this incident is asked to call the Drivewatch Hotline on 0800 174615.


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The communal trend in restaurants is really starting to take over the world. First, it was an option to share small plates, now it is a requirement. "What? You want your own meal? Where do you think you are, Arby's?" I am convinced that the next big thing is literally going to be a shared plate, with the stranger sitting next to you. The hipster diner will use the "going green" excuse and all of a sudden, it will be all the rage.
Based on my thoroughly researched evidence above, it was no surprise that Nico Osteria, the restaurant that requires a reservation three months in advance, had an updated version of communal tables: tiny tables for two that are an inch away from each other.
My dinner partner and I spent the first hour of our meal eavesdropping on the couple's conversation next to us. This included a tear filled storm-off from the woman and lots of condescending digs from the man. We contemplated getting involved at one point, but ultimately decided against it.
Shockingly, plates are meant to be shared at Nico Osteria. Here is what we ordered:
The quality of the food at Nico Osteria is "the best in the world" according to the waiter. According to me, it was good, but over hyped. With Chicago's restaurant scene growing by the nanosecond, it is not uncommon for some of the best spots to be hidden gems, many of which are dives and dirt cheap. Thus, a shi shi location, twenty dollar drinks and a host who wants to take my cardigan to the coat check, no longer define the best of the best.
Bottom Line: Worth checking out, but not mind blowing.


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Contact Us
Need help fundraising? Have questions about prostate cancer? Looking for a topic expert for a news story?
Give us a call; we're happy to answer any questions you might have about Grow & Give, ZERO - The End of Prostate Cancer (that's us!), the disease, other ways to get involved in the cause, or whatever else you might need.
We're in the office Monday through Friday, 9 a.m. to 5 p.m. EST.
(202) 463-9455 or (888) 463-9455
We're pretty good about returning emails within 24 hours.
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|Alternative names
|Ris à l'amande
|Place of origin
|Serving temperature
|Cold, with cherry sauce
|Main ingredients
|Rice pudding, almonds, whipped cream, vanilla
|Cookbook: Risalamande Media: Risalamande
Risalamande (also spelled as ris à l'amande and other variants, though risalamande is the only spelling authorized by Dansk Sprognævn;[1] from pseudo-French riz à l'amande meaning "rice with almonds"), is a traditional Danish dessert typically served at Christmas.
Risalamande was created in the last part of the 19th century. It is made out of rice pudding mixed with whipped cream, vanilla, and chopped almonds; and is usually served cold with a cherry sauce (kirsebærsovs).
It gained popularity when rice pudding became more common. Until then rice pudding had been a very exclusive dish, as making it required two expensive, imported ingredients: rice and cinnamon. After World War II, risalamande experienced an increase in popularity, being touted as a "savings" dessert: adding whipped cream (which was easily available) to the still fairly expensive rice would make the rice last longer. In order to minimize costs, risalamande was frequently made without almonds during this time, too.
A similar traditional Danish Christmas dish, risengrød, is essentially risalamande before the whipped cream, vanilla, and almonds have been added, and is typically served hot, topped with cinnamon and butter.
Nowadays, it is very common to make a large batch of rice pudding for dinner on lillejuleaften ("Little Christmas Eve", i.e. December 23), a part of which is kept until Christmas Eve and used to make risalamande, which is eaten as dessert after the big Christmas dinner.
Normally, a whole almond is added to the dessert, and the person who finds it wins a small prize — such as a chocolate heart, a marzipan pig, or a small board game.[2] Part of the game involves the finder concealing their discovery as long as possible, so that the rest of the company is forced to eat the entire dish of risalamande, even after they have already devoured a large Christmas dinner.
In Sweden and Norway
- Read more at Rice pudding#Nordic countries
In Sweden, this dish is called ris à la Malta, which is a corruption of the Danish name. Typically it's made of chilled left-over rice pudding, whipped cream, sugar and vanilla, with or without almonds. The person finding a hidden almond in the dessert is expected to get married before next Christmas. A variety containing diced oranges is called apelsinris. The dish is mostly served with either a smooth cordial-sauce or jam. Ris à la Malta is commercially sold as a snack under the name "Risifrutti" since 1992.[3]
Norwegians have a similar dish called riskrem ("rice cream"), and like in Denmark the person finding a hidden almond in the dessert wins a mandelgave (almond-gift) in form of a marzipan pig or the like. The dessert may contain almonds for flavour, but mostly chopped on top as decoration. In Norway, the sauce is also normally made of raspberry (or even strawberry) rather than cherry.[4]
See also
- ↑ Den Danske Ordbog, risalamande entry. Retrieved 25 December 2010.
- ↑ Danish Christmas Traditions. Retrieved 25 July 2009.
- ↑ http://www.risifrutti.com/?id=161
- ↑ "Norwegian Wikipedia:Riskrem". Retrieved 25 May 2013.


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Monitoring a tank is pretty simple. These tanks can contain a variety of substances and correspond to the public and private sectors business. This process is used in various companies and refers to many different types of Monitoring a tank. It may refer to chemicals, petroleum gas, natural gas and propane, water systems and process concerns agriculture. This inventory management and safety standards to ensure they are meeting. Tracking and data acquisition ensures that these two key requirements met.In regarding Monitoring a tank, tank monitoring ensures that the levels are correct, that the desired amount is maintained. These data will provide information on the level and this in turn can be performed, if recharging is needed and when. Tank monitoring is key in inventory management because it prevents the depletion of production shortages, cuts, and improper filling. Tank monitoring will also enable the company to plan the management of inventory levels, such as fillers and forecasting methods.
Many tanks may contain toxic, corrosive or flammable materials. The information collected will ensure that these substances are complying with safety requirements and no threat. There have been many examples of leaks and explosions caused due to faulty data monitoring.Not tank are just these leaks or explosions or other very harmful accidents to the surrounding environment, and possibly surrounding communities, but can also be harmful to business. A business experienced a key holding tank accident may have trouble recouping losses and, in some cases, be completely unable to recover.
Monitoring a tank Technology
There are several companies providing supply tank technology and software, and some may run a company or specific industry while others have multiple uses and interconnected components and are applicable to a variety of industry.The company or sector to be exactly what their needs and options and work with suppliers of technology and software to ensure proper and optimum inventory management and that all safety requirements are met. Monitoring a tank is wireless data collection for substances stored in inaccessible environments and it is key in managing inventory for a product that can not easily see or physically monitored. Remote tank monitoring is important not only that maximizes the potential of business and profits, but adheres to safety standards to protect the public as well as business interests.


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Donald Trump continues to take the United States, once a well-respected country, to new lows. Recently, Trump reminded everyone that he is a flaming racist when he retweeted hateful anti-Muslim videos on Twitter.
Those videos had actually come from UK-based Jayda Fransen, who is notorious for being a far-right anti-Muslim bigot. Naturally, that's pretty much grounds for becoming one of Trump's favorite influences. The videos Trump retweeted depicted Muslims assaulting people, with the purpose of them being to stoke bigotry and create more division and ethnic hatred.
The majority of the country — and much of the world — is absolutely shocked and disgusted that the President of the United States would actually think that sharing such a thing is appropriate. A brilliant reaction to this news has actually come from the United Kingdom, as UK Parliament members couldn't help but address this horrific issue and blast Trump for being an embarrassment to the human race.
In the video below, Labour MP Stephen Doughty trashes Trump for sharing "inflammatory" videos with his followers, with the sole purpose of riling up his hateful troops. Doughty's remarks were supported by his fellow MPs, with several of them shouting "Hear, hear!" One MP yelled that Trump's tweets were "disgraceful."
You can watch the video below:
Point of Order raised in British House of Commons regarding President Trump's tweets. pic.twitter.com/w4ZIDMMZGo
— CSPAN (@cspan) November 29, 2017
Things are pretty bad when officials from other countries have to condemn your president because the people who elected him clearly don't have the backbone to do so. Many Americans have weighed in on this terrible move by Trump, but the prominent Republican politicians who should be addressing this issue have been silent. Trump deserves to be condemned on the world stage, and we're glad that at least other countries aren't afraid to.
Featured image via Mark Wilson / Getty Images


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In the first installment of this mini-series, we outlined how you efficiently prepare for performance testing. In the previous article, we got into the nitty gritty of what tests to run, and how to run them.
The final step toward ensuring you're shipping high-performance applications and websites is to continuously test throughout your software development lifecycle.
If you're a DevOps-minded organization that's already working with Continuous Delivery and Continuous Integration (CD/CI) tools, then you're off to a great start.


text: Anyone here own a monkey or chimp? It's something that I've wanted since I was a kid, but there are no breeders close by for me to check out and for as much as they cost, I don't wanna take any chances. I'm fully aware of all the complications, problems, and dangers that can come from owning one, but it's still something I want to look into. Anyone?