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On her sixth album So Good, So Right: Nicole Henry Live, Henry demonstrates her gift for sublime interpretation as well as her love for the emotionally tinged soul, pop and rock songs that were staples of the 1970's. The 13-track live album, which was recorded at Henry's sold-out performances at Feinstein's in NYC in May 2012, showcases her soulful, inspired interpretations of some of her favorite classic hits of the decade from iconic artists including Bill Withers, Aretha Franklin, Joni Mitchell, James Taylor, The Commodores and Gladys Knight.
"I really connected with the music of the 70's-all those incredible grooves and great lyrics that conveyed hope and love and being free," comments Henry. "Growing up I can remember my parents listening to lots of soul and pop music, and so many of those songs just gave me a great feeling of happiness. The artists of that time were true craftsmen and their music had such a broad sound, accessible by people of all races- that's the kind of music I loved-no definitions! I wanted to revisit that time and those emotions and share them with my fans."
Featured tracks on the album include the title track, Brenda Russell's 'So Good, So Right,' which Henry loves for the "simplicity of the adjectives Good and Right and how, in this song, "SO" completely explains that feeling of inexplicable perfection of that moment. It just IS." Henry grew up on Aretha Franklin's music so when album producer Matt Pierson recommended to her the song 'Spirit in the Dark,' from Franklin's 1970 album, she knew she had to cover it. "I grew up listening to Aretha's 1972 live gospel album Amazing Grace- as far as I'm concerned, everything Aretha sings is gospel," says Henry. "This song reminds people to be free, look within themselves, and lose control when you need to – a revival of spirit." Other tracks include the great Bill Withers 1972 classic 'Use Me,' which Henry says "shows just how funky he was, and the lyrics show how direct his writing could be. The song's meaning is obvious…GOOD LOVING goes a long way!"
Henry also shines on tracks such as Joni Mitchell's 'Big Yellow Taxi,' where, as Henry explains, "Joni Mitchell's whimsical melody, combined with her sad lyrics, always throws me for a curve on the last verse," and Stealers Wheel's raucous 'Stuck in the Middle,' where Henry showcases her signature attitude. So Good, So Right: Nicole Henry Live closes with Fleetwood Mac's iconic 'Landslide,' a beautiful song Henry interprets to be about "learning to love, growing up, accepting one's past sacrifices, and making decisions about where you're going."
Growing up in a musical family in Bucks County, PA, Henry immersed herself in the arts early on, singing in school and churh, and studying cello and ballet. After graduating from the University of Miami with a degree in Communications and Theatre, Henry launched a successful acting career, appearing in commercial roles as well as a series of voiceover assignments. But she directed her strongest passion toward the development of her full-time singing career which was quickly rewarded in her present hometown, when the Miami New Times named Henry "Best Solo Musician 2002."
Henry's 2004 debut CD release, The Nearness of You, won considerable attention from audiences and critics in the U.S. and in Japan, where they named Henry Best New Jazz Artist of 2004. The following year, Henry's Teach Me Tonight reached #1 in Japan and was named HMV Japan's Best Vocal Jazz Album of 2005. 2008's The Very Thought of You substantially expanded her American audience, reaching #7 on Billboard's jazz chart. 2011's Embraceable, a slight departure from her prior recording, reached the top 20 on jazz and smooth jazz radio charts and was a creative triumph for Henry, increasing her repertoire of originals, and further established her as a peerless interpreter of jazz, and pop standards, transcending genre boundaries.


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text: If you're dumb, you forget that plastic surgery is surgery with an extra word in front of it, a doctor tells CNN in their article on getting nip/tucked safely. As with any surgery, there's no real way to make it completely safe, but here are five tips from their article that you should follow to improve your odds. In fact, they're probably good tips for any kind of surgical procedure. [More]


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Former President George H.W. Bush, 89, sported a clean-shaven head in solidarity with a 2-year-old named Patrick, who lost his hair when he started being treated for leukemia.
The 41st president was pictured in a wheelchair today on the family's Maine compound sporting his signature colorful socks, with Patrick seated on his lap. Both he and Patrick wore light-blue shirts, although Patrick had a couple of toy cars, as well.
Patrick is the son of, Jon, a member of Bush's Secret Service detail, many of whom also went under the razor to support the young cancer fighter. (Last names were withheld at the request of the family, Bush's office said)
Bush and Barbara Bush have an even more personal connection to Patrick's fight. They lost their second child, Robin, to leukemia 60 years ago when she was 4.
Members of the Bush Protective Detail have set up a website, www.patrickspals.org, to help pay for Patrick's medical bills. And they have organized the Inaugural Patrick's Pals Motorcycle Benefit Run in Kennebunkport, Maine, to help pay for Patrick's treatments.


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(Video) Who is Marvel's Purple Man?
November 22, 2015 | Comic Book History|
Get The Purple Man's Comic Book Backstory
Have you watched Marvel's Jessica Jones on Netflix yet?
This video will help provide the essential backstory on Jessica's nemesis, Zebediah Kilgrave, aka the Purple Man, played David Tennant. The character's origins as a member of Daredevil's rogues gallery starts to tie the Netflix storylines together.
Watch this video and let us know what you think of the new series:
You may also find it useful to watch this video from a previous post: Who is Jessica Jones?


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Saudi Woman Spared Lashing
Sheima Jastaniah will not be lashed for breaking Saudi Arabia's female driving ban after the country's leader, King Abdullah, intervened to overturn her sentence. Originally sentenced to at least 10 lashings, Sheima was the first woman to face legal punishment for breaking the ban. The sentence came just one day after King Abdullah announced plans to extend voting rights to women in 2015.


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There are various laws concerning dogs and the responsibility of their owners. It is worth taking on board these laws if you are a dog owner or you are a considering buying a dog. A failure to adhere to these rules can land you in court and potentially facing a fine and in extreme cases the loss of your pet and maybe even a ban on keeping dogs or other animals in the future.
These are some of the laws that apply to dog owners:-
The Control of Dogs Order 1992 says that all dogs on the highway, or in a public place must wear a collar and have an identity tag which gives the owner's name and address.
Section 27 of the Road Traffic Act 1998 states that: "A person who causes or permits a dog to be on a designated road without the dog being held on a lead is guilty of an offence. In other words, you should keep your dog on a lead when on a public road.
The Environmental Protection (Stray Dogs) Regulations 1992 says that a local authority must appoint a dog warden to deal with stray dogs found in their area. An owner who has lost and wishes to reclaim their dog which has strayed, may only do so if they have paid the Local Authority's charges incurred by detaining the dog, together with a fine on a standard scale.
The Dangerous Dogs Act 1991 is perhaps the most well known law concerning dogs. Section 3 of the Act applies to all dogs, not just the so called fighting dogs such as American Pitbull terriers. The Act also applies to all dogs that are dangerously out of control in a public place. Dangerously out of control is defined as being 'on any occasion in which there are grounds for reasonable apprehension that it will injure any person'. Generally, if a dog bites someone then it will be presumed to have been dangerously out of control. A public place is defined as including any place 'to which the public have or are permitted to have access'. A dog owner found guilty of allowing their dog to be dangerously out of control in a public place, may be ordered to have their dog destroyed, may be fined or be disqualified from owning a dog for any time the court sees fit, or a combination of all three. This law would cover the situation where your dog bit someone in a public place.


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Bubba the Love Sponge, the horrible Tampa-based shock jock who last showed up in this space when he suggested that the death of half a million Haitians would actually be a good thing, has decided to hold a face eating contest in the wake of the horrific attack that occurred here in Miami. Because Bubba the Love Sponge is horrible, and of course he would do something like that.
In a stunt dubbed the "Homeless Miami Cannibal Face Eating Challenge," Bubba strapped masks made out of meat to two bearded men and then had two other people eat the meat in what we guess is a race. This is funny in the same way that looking at your own shit in the toilet is funny, which is to say, not very to anyone with an IQ over 45.
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The full video appears to be on some subscription website that also includes such classy fair as the "Trayvon Martin Challenge" and the "2012 Mexican Olympics" in addition to a lot of videos that feature boobs. Not that we want to publicize the site. There's already enough stupid shit for free on YouTube, and if you want to pay for boobs then, well, buy some real porn.
Anyway, coming up next week on Bubba's show: something called "the gay mall challenge," and, perhaps most offensively, Tucker Carlson.
Follow Miami New Times on Facebook and Twitter @MiamiNewTimes.


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While we are on the subject of Kimpton...Tom Peters had a great post today on the subject of Four Season's flowers.
You see, flowers make you FEEL good. The Kimpton gold fish (having a pet in your room) just don't "move" you that much. It's going to be a long road to pass Four Seasons. But, I bet it will be interesting.
I happen to like Kimpton, and am hoping they turn that brand into something really fantastic and memorable.


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This is the only club you'll need to live the best version of yourself!
Experience the benefits of Honolulu Club membership for yourself!


text: It's been a while since the last post. North, east, West, South take longer than expected to edit. I also wanted to explore the shady side streets of Queens Plaza. It's an interesting mix of brand new constructions, and old manufacturing buildings. I am pretty sure they will be gone in 10 years.


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Unlike many other teenagers his age, Marshon Mayes dreams about serving in public office. The 17-year-old East Side resident said he has had an interest in politics and law enforcement for as long as he can remember.
Unlike many other teenagers his age, Marshon Mayes dreams about serving in public office. The 17-year-old East Side resident said he has had an interest in politics and law enforcement for as long as he can remember.
�I want to be mayor, governor or maybe a district attorney,� Mayes said.
Two summer employment programs funded by the city and Franklin County are giving Mayes and other local teenagers the opportunity to explore public office and other career options.
About 2,500 young people are working in paid internships with public and private employers this summer through the S.O.A.R.hire and YouthWorks programs.
The countywide YouthWorks was created this year to supplement S.O.A.R.hire, which is geared toward city residents and is now in its third year, said Lance Porter, a spokesman for the Franklin County Department of Job and Family Services, which runs YouthWorks.
Both programs pair people ages 14-24 with academic institutions, businesses and government offices. The majority of participants are high-school age and disadvantaged, Porter said.
For those paired up with public agencies, he said, the internships are a valuable opportunity to learn how government works while developing skills that can help them land a job in the future.
Mayes and three other interns are working for the Franklin County commissioners. The group has learned computer and accounting skills and how to catalog information from bonds and resolutions, in addition to regularly sitting in on board meetings.
�It really gives them an idea if public service is something they want to go into,� Porter said.
In S.O.A.R.hire, 150 of the program�s 1,200 interns are working with the city, including in the mayor�s office, Columbus Public Health and the Department of Technology, said Brittany Westbrook, a spokeswoman for the Central Ohio Workforce Investment Corp., the agency in charge of the program.
Both programs receive most of their funding from Franklin County�s Temporary Assistance for Needy Families fund, a combined $4.25 million. Additionally, the city put up $440,000 for S.O.A.R.hire this year, Westbrook said.
While the private companies employing 450 interns in S.O.A.R.hire pay their wages directly, YouthWorks covers the wages of interns working for private businesses. Participants in both programs earn at least $10 an hour and work 20 to 30 hours a week.
La�Fred Gibbons, 19, a Columbus native studying engineering at Tuskegee University in Alabama, has worked in the mayor�s office for a month and a half on projects that included immigration reform and community-service initiatives. The second-time S.O.A.R.hire intern said he has met a lot of community leaders and now thinks city government isn�t too difficult to understand.
�It�s great to see how the city really cares about our problems,� he said.
Federal funding for summer youth employment in central Ohio was cut two years ago, Westbrook said. In response, the city and county turned to other sources of money and cooperated with private businesses, she said.
The majority of S.O.A.R.hire internships began last month and ended last week. YouthWorks interns for the most part started four weeks ago and finish in August.
�I didn�t know a lot of these things existed until I came here,� said Jalen Cureton, 16, an intern with the county commissioners. �It makes you feel like you can come in and try to change something.�


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For the first time in team history, there is no one from Toronto or the GTA on the Maple Leafs roster.
The region has 45 players among the 634 listed on current NHL rosters but none with the Leafs, a sore point that irks John Gardner, president of the Greater Toronto Hockey League, the biggest minor hockey league in the world.
"Toronto has been a little remiss in not picking up some of our graduates," said Gardner. "We have put some pretty good players in the league, above the normal standard. They never end up in Toronto."
It bothers Gardner that recent GTHL grads like Jeff Skinner, Tyler Seguin and John Tavares toil elsewhere, much like former GTHL grads that went on to stardom like Paul Coffey, Ken Dryden and Brendan Shanahan before them.
Leafs GM Brian Burke is fond of saying he never looks at the passport of a player he wants to sign, draft or acquire in a trade. Burke did not respond to a request for an interview for this story.
But assistant GM Dave Poulin, a Toronto native, said the lack of local players on the Leafs is "really a total coincidence. Rosters can be very cyclical. When we evaluate players, the place of birth or where they played their minor hockey never comes into play, unless it can affect their availability to us."
Even the Ontario contingent on the Leafs is down to just one player — Nazem Kadri — and for one day this week, when Kadri was assigned to the Marlies, there wasn't even a single player from this province on the team. Imagine the Montreal Canadiens without a Quebecer.
This is a marked departure from the team's past when it used to seek out Ontario skaters like Doug Gilmour, Dave Andreychuk, Gary Roberts and Joe Nieuwendyk.
Even the reasonably small Prairie town of Lloydminster has two Leafs — Colby Armstrong from the Saskatchewan end of the border town, and Clarke MacArthur from the Alberta side of the town.
The Leafs roster is made up mostly of Western Canadians and Americans.
"We suffer through it," said Gardner. "The team's half American now, not that I'm trying to distinguish between the Canadian hockey player and American. But is there something wrong with our system?"
Hockey historian James Duplacey says the lack of Toronto players is an inevitable conclusion, reflective of the way the NHL does business rather than a slap in the face for local hockey.
Duplacey remembers when St. Michael's College and Neil McNeil High School were the "breeding ground" that formed the "line of ascension" to the Maple Leafs until the introduction of an NHL entry draft.
"The Toronto Maple Leafs have never had a mandate to find, groom or promote local talent," said Duplacey. "They have never needed a homegrown player to sell tickets or promote the team and have been particularly clumsy when it comes to dropping the ball on Toronto-trained talent when they've had an opportunity to bring in a high name homegrown free agent.
"In the first 40 years of the team's existence, they were able to locate and sign local talent particularly because the Toronto Marlboros and the St. Michael's Majors operated within their jurisdiction. Even still, the Leafs passed on Red Kelly and Ted Lindsay, missed Ken Dryden and failed to see the potential in Gerry Cheevers."
The 1992-93 Maple Leafs, arguably the most successful team since the 1967 Cup winners, had 14 players from Ontario, including three from the GTA (Peter Zezel, Mark Osborne and Rob Pearson).
Though Burke may be loathe to admit it, this may well be reflective of a philosophy. Getting rid of a local kid — players who grew up in the shadow of the Leafs empire — may be a way getting rid of a sense of entitlement. Or perhaps the Leafs feel local kids are distracted or intimidated playing for the team they grew up idolizing.
"There are advantages and negatives to being a local guy," said Ex-Leaf Matt Stajan, from Mississauga. "You've got to work with it and find a way to be your best every day and block what's going on outside."
Until the Leafs traded him to Calgary, Stajan "never really lived away from Toronto. You're familiar with your surroundings, your best friends that you grew up with around all the time. Your sister, your parents, your aunts and uncles, your parents. That's a big-time advantage."
But there's a downside, "like people always asking you for ... tickets. All my family and friends learned pretty quick (not to). You still get the questions trying to take advantage of what you do. That's life."
The last GTA player with the Leafs was John Mitchell of Oakville, a frequent healthy scratch last year until being dispatched to the New York Rangers. Local players Mike Zigomanis, Luca Caputi and Jesse Blacker play in the farm system.
The last time the Leafs had a significant number of players from the GTA on their roster was the 2008-10 era, including Stajan, Carlo Colaiacovo and Jamal Mayers.
Former GM Jim Gregroy, architect of the Leafs teams of the 1970s that featured the likes of local players Mike Palmateer, Jimmy Jones, Mike Pelyk and Brian Glennie, said hometowns of players were discussed in pre-draft meetings.
"But it wasn't a priority," said Gregory, now a league executive. "The impact on selection was who we thought was the best. It didn't matter if they were from B.C., or Quebec, or Ontario."
It was Gregory who is widely credited with starting the influx of European hockey players with the signings of Swedes Borje Salming and Inge Hammarstrong in 1973.
The geographic makeup of the Maple Leafs
Alberta — 4
Sask. — 4
Quebec — 2
Sweden — 2
Manitoba — 2
Russia — 1
Belarus — 1
Ontario — 1
Cities/towns that have contributed the highest number of players to the Leafs all-time roster (815)
Cities/towns that have contributed the highest number of players to the Leafs all-time roster (815).
Toronto/GTA — 115
Winnipeg — 28
Ottawa — 25
Montreal — 23
Thunder Bay (Ft. William/Pt. Arthur) — 14
Sudbury — 13
Edmonton — 13
London — 13
Regina — 13
Calgary — 12
Hamilton — 12
Windsor — 11
Timmins/S. Porcupine — 11
Kingston — 10


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The Translational Medicine Ontology and Knowledge Base: Using Semantic Web Technology in Personalized Medicine for Data Integration. In: AMIA Summit on Translational Bioinformatics, March 7-9, 2011, San Francisco CA, USA. 2011.
MIND Informatics develops and applies integrative computational methods in biomedical and brain research, working with leading clinicians and researchers to understand and cure neurological disorders.


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Sunday, December 15, 2013
11 comments:
- Sue Marrazzo said...
This looks so FUN!!!!
Thanks for showing us all....merry Christmas to all!
- December 15, 2013 at 2:14 AM
- Jackie said...
Lovely cards
I am sure they will now be hooked and start on their own crafty journey.
Thanks for all the inspiration.
Merry Christmas to you and all the cubby hole crew x
- December 15, 2013 at 7:01 AM
- Sammy said...
Looks like a fabulous time was had by all! The cards look great! x
- December 15, 2013 at 9:23 AM
- rachel said...
looks like you all had a fantastic time - and the ladies did you proud - love your card too Kath xx
- December 15, 2013 at 9:29 AM
- Redanne said...
You certainly chose some lovely designs for the first timers and the results are fantastic. Love the card for the Grandkids, whatever did we do before Frantage! Love it. Hugs, Anne x
- December 15, 2013 at 9:38 AM
- craftyfoxglove said...
Didn't they do well! I remember the first cards I made looked liked my kids had done them! I bet they'll be hooked from now on. Love the one for the grandchildren.
- December 15, 2013 at 12:26 PM
- Christine B. said...
Lovely cards, HUgs x ChrisB
- December 15, 2013 at 3:39 PM
- Paper Junkie said...
I do hope the class came with a warning - "The health of your bank balance could seriously be affected if you become addicted to craft"! I'm not called Paper Junkie for nothing...It looked great fun Kath and your snowman card is brill. X
- December 15, 2013 at 4:20 PM
- trish said...
Hi Kath, lovely cards they must have been delighted them, the snowman cards beautiful the kids love snow. Hope it stays away except a little on Christmas eve to help Santa on his way...Trish
- December 15, 2013 at 4:30 PM
- Rea' said...
Such cute cards, love the snowman blueprint stamp... so fun !
- December 16, 2013 at 4:32 AM
- Rena Sawatski said...
Great cards . Love the one you did for the grandkids. Did you use embossing powder for the snow?
- December 16, 2013 at 4:55 AM


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LaCie announced a dual-disk Gigabit network storage and media server called "LaCie Network Space MAX," design by Neil Poulton. Network Space MAX includes two large-capacity hard drives that can be configured for maximum security (RAID 1) or maximum capacity (RAID 0). If protecting your data is a priority, the RAID 1 mode will ensure automatic disk mirroring – meaning all files will be copied onto each of the disks. If one drive fails, data willn't be lost. Network Space MAX features a media server, making it easy to stream files to any connected computer or any UPnPTM/DLNA compliant device (such as a PlayStation3 or Xbox). Computers with iTunes installed can also stream the music stored on the Network Space MAX. The entry level LaCie Network Space MAX features a 2TB capacity and is available through the LaCie Online Store, LaCie Corner, and LaCie Reseller+ starting at £249 (incl VAT).
More Info: Amazon


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LIRR Talks Break Down, Service Will Decrease To Prepare For Strike
A deal to avert a Long Island Rail Road shutdown remained elusive Monday after the latest round of talks between leaders of unions and the Metropolitan Transportation Authority broke down without an agreement.
Thomas Prendergast, chairman and chief executive of the authority, said "there truly is a gulf" between both sides as a possible strike looms as soon as Sunday.
Anthony Simon, a chief spokesman for a coalition of LIRR unions, said negotiations had collapsed and that the eight unions in the talks are now proceeding with plans for a strike.


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Welcome to New Author: Shelley Nolan
Shelley Russell Nolan is an avid reader who began writing her own stories at sixteen. Her first completed manuscript featured brain-eating aliens and a butt-kicking teenage heroine. Since then she has spent her time creating fantasy worlds where death is only the beginning
DATE 01 Jun 2017
TAG Shelley Nolan


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The symmetry principle has been a central tenet of the history of science since at least the 1970s, and in my view it is a sound and valuable principle. However it is often confused with principles that are neither sound nor valuable, some of which are positively harmful for the study of past science. For example, the symmetry principle is sometimes expressed as the view that "truth" cannot explain the beliefs of past scientists. My main aim in this series so far has been to show that this view is hopelessly vague, and that on many readings it is false. In this post I will say the same about another aspect of the symmetry principle, namely the claim that historians should explain true and false beliefs "in the same way." I'll run through five readings of this claim, only the first of which deserves to be called the symmetry principle. Truth/falsity is not good evidence for good/bad reasons (Symmetry Principle) To use an example from my first post in this series, Galileo had a true theory of the moon and a false theory of comets. It is tempting to infer that he reached the moon theory through observation, experiment, and careful reasoning, whereas he reached the comet theory through arrogance, spite, and self-interest. That is, it is tempting to infer from the truth of the moon theory that Galileo held it for good reasons, and to infer from the falsity of the comet theory that he held it for bad reasons. Most historians of science, including me, think that both of these inferences are flawed. In general, the truth-value of a belief is not a good guide to the motivations of the believer. The inference from the former to the latter is what I call The Fallacy. Let's not worry about why it is a fallacy, a question that I intend to answer in a later post. The important point is that it is a fallacy, and that the symmetry principle properly understood is simply the assertion that this is so. Hence I will call this assertion the Symmetry Principle (note the capital letters). Some might object to the Symmetry Principle on the grounds that there is no principled way of distinguishing good reasons from bad reasons. In practice, however, historians of science seem perfectly capable of making this distinction. The evidence for this is that they often criticise other historians for violating the symmetry principle, and to do this they must be to make the distinction in question. This is true no matter which version of the symmetry principle the critics have in mind, since all of the versions that I know of rely on some variant of the distinction between good and bad reasons. The Symmetry Principle must be distinguished from the following four claims. All of these claims have masqueraded as symmetry principles at one time or another. All of them look like the Symmetry Principle on the surface, but none of them follow from the Symmetry Principle and none of them should be called symmetry principles, either because they are false or because they have more to do with asymmetry than symmetry. Truth/falsity is never aligned with good/bad reasons (Exclusion Principle) The Symmetry Principle is quite a modest, minimalist principle. All it does is ban a certain inference, namely from truth-values to kind-of-reason. Banning an inference is not the same as saying that the conclusions of that inference are always false. Historians, just like scientists, can be right for the wrong reasons. Fallacious arguments can have true conclusions. For example: dead people cannot walk; Socrates cannot walk; therefore Socrates is dead. Or: my nicotine patch company will make more money if smoking causes lung cancer; therefore smoking causes lung cancer. Yet historians often interpret the symmetry principle to mean that truth-value is never aligned with type-of-reason. On this view, it is always an error to claim, of some true theory T, that a scientist believed T for good reasons and that his critics were mislead by their political interests or religious preferences. On this view, Galileo could not possibly have had good reasons for believing his moon theory but bad reasons for believing his comet theory. That option is ruled out a priori (hence my name for this principle, the Exclusion Principle). Galileo must have either had a mixture of reasons for believing both theories, or only bad reasons for believing both, or good reasons for the comet theory and bad reasons for the moon theory. Unlike the Symmetry Principle, the Exclusion Principle is hard to defend. Granted, there is a sense in which something like bad reasons are a precondition of all scientific activity. Social relations, for example, are sometimes associated with "bad reasons" for belief, yet it is impossible to do science worthy of the name without forming social relations of some kind. Here it is important to distinguish preconditions of belief from factors that shape belief, a distinction I borrow from Steven Shapin (although he might not agree with the application I am now making of the distinction). It is a precondition of scientific activity that someone pays for it (for example). But it does not follow that funding source always shapes belief, ie. that a scientist's funding source is always a good explanation of why they believe theory X rather than a rival theory. It is also important to distinguish between absolute claims and relative claims. Probably there are no scientific beliefs that are pure in the sense that no bad reasons enter into their causal history. However it is very plausible that good reasons sometimes dominate over bad reasons. And there is no law of history that says that the good reasons never fall on the side of the true theories. Historians should never omit the good/bad reasons for false/true theories (Completeness Principle) The Symmetry Principle and the Exclusion Principle are claims about how historians reason about past science. By contrast, the third principle on my list is about what they should include in their books and articles. The Completeness Principle—the name is my own—states that whenever a historian discusses a true belief he must discuss the bad reasons the scientist had for holding that belief, and not just the good reasons. Conversely, discussions of false theories are lamentably incomplete if they omit good reasons in favour of bad ones. In other words, it is not enough for a historian to believe that truth/falsity is rarely aligned with good/bad reasons. He must also structure his narratives around this belief. It seems to me that the Completeness Principle is a bad idea, and it would be a bad idea even if the Exclusion Principle were true. The worry that lies behind the Completeness Principle is that books and articles might give misleadingly one-sided accounts of past science. There is something in this worry—after all, what's the point of believing the Symmetry Principle if that belief is never reflected in our written work? Nevertheless, this worry should not lead to a blanket ban on narratives that are one-sided in the way I have just described. Such a ban would be like a ban on narratives that consider French science but exclude German science, or a ban on those that discuss botany but not mineralogy. When we read books that only cover French cases, or that only cover botany, the reasonable response is usually to assume that the author has focused on these cases out of convenience, or because that is what they know. We do not usually assume that the author denies the importance of German science, or of mineralogy. Likewise, if an author writes a book about Lavoisier's biochemistry (for example) and says nothing about the French Revolution, we should not assume that the author denies the relevance of the French Revolution to Lavoisier's biochemistry. Perhaps the French Revolution simply has little bearing on the argument the author is trying to make about Lavoisier's biochemistry. Or perhaps the author omitted social and political factors in order to zoom in on Lavoisier's attitude towards measurement. Historians should systematically omit good reasons in order to focus on the others (Methodological Relativism) Whereas the Completeness Principle says that historians should report good and bad reasons equally, this principle licenses them to omit good reasons. According to this principle, it is sometimes valuable for historians of science to ignore the experiments that scientists performed, the data they collected, or the chains of reasoning they articulated in order to defend one theory against another. These omissions are valuable, I take it, because they allow the historian to hone in on the social and political reasons for the beliefs that past scientists endorsed. I have no objection to Methodological Relativism as an occasional heuristic. Just as some authors may want to ignore the French Revolution in favour of Lavoisier's experimental practice, others may want to do the reverse. However I agree with Will Thomas that Methodological Relativism is a recipe for disaster if it is read as a general rule of historical method. And this is how it tends to be read, in my experience, especially when it is conflated with the Symmetry Principle, which is indeed a general rule of historical method. Even if Methodological Relativism were a viable general principle, it would be misleading to call it a symmetry principle. It may be symmetric with respect to true and false theories, treating both in the same way, but it is Assymmetric with respect to good and bad reasons, since it focuses on the latter at the expense of the former. Bad reasons are the dominant causes of both true and false beliefs (Social Constructivism) This claim, like the previous one, is asymmetric with respect to good and bad reasons, since it gives priority to bad reasons. Unlike the previous claim, it does not just say that our narratives of past science should be written asymmetrically. Instead it says that that past science really was asymmetric. This claim accepts that good reasons were at work in past science, but insists that they were less powerful or less decisive or less fundamental than the bad reasons. I hesitate to include this claim on my list, since people do not usually call it a symmetry principle and because the phrase "social constructivism" is such a fraught one. I include the claim anyway because it looks a bit like some of the other claims on this list, and because readers might wonder where it fits into this survey. I've plumped for "social constructivism" as a label for this doctrine because, for all the ambiguity of the name, it is usually applied to the claim that one kind of cause (whether we call these "social factors" or "bad reasons" or something similar) makes a larger contribution to scientific beliefs than another kind of cause ("epistemic factors" or "good reasons" or something similar) . Another reason to mention Social Constructivism here is that it is often the end of a chain of reasoning that begins with the Symmetry Principle. For example, a common gambit is to observe that there are good reasons on both sides of many scientific debates, and to infer from this that good reasons cannot explain why people take the sides they do. After all, the argument goes, how can a commonality explain a difference? Needless to say, I do not endorse this argument or any of the others that lead from a laudable symmetry to a paralysing asymmetry. To describe these arguments would require another post, and this series is already too long for that. I'll simply conclude that there are several different claims that have been called symmetry principles in the last few decades, that several of these claims are not worthy of that name, and that we should not confuse those imposters with what I have called the Symmetry Principle. In case you missed it, the Symmetry Principle is made up of the twin claims that the truth of a belief is not good evidence that the believer had good reasons for holding it, and that the falsity of a belief is not good evidence that the believer had bad reasons for holding it. The burden of my next post is to say why the Symmetry Principle is a good principle. This task is harder than it might seem, as we shall see. Expand post.
Malheureusement je ne traduis plus tous les posts que j'écrit sur ce blog. Si vous voudriez lire les posts qui ont été traduits, veuillez cliquer ici. Agrandir ce message.


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text:
Pub landlady cleans up soot damage left by Southern Comfort drinking coalman at Jamaica Inn
I bumped briefly into our butcher this morning for the first time in a couple of weeks,due to the inordinate amount of time I'm spending at the new pub.
Hello stranger!Hows it going up on the hill?? says he. *knowing big wink*
Self:Not bad thanks
Butcher:Interesting eh?????(Folding arms slowly,relaxing one leg and waiting for the gory details)
Self:Yes its great thanks,loving it....(lying through teeth)
To be honest I'm afraid the New Pub might be a bit more of a challenge than I had first anticipated.I haven't yet furnished you with the full story..
It was reopened a couple of years ago following a lengthy campaign by villagers to prevent it being turned into a residential home,having been closed for more than a decade.In the two years since the reopening two or three landlords have passed through...
Over the last couple of weeks I've seen things that never in a month of Sundays did I expect to see in a pub..
On the first night a fellow strolled up to the bar, black from head to toe apart from his ginger hair which was teazled into a Gummidge inspired style and the large gold signet ring on his wedding finger.
'He must be the coalman' I whispered..
'I didn't know coalmen still existed' said Ems
Self:Well of course they still exist,where do you think we get the bleeping coal from???
Thankfully,Tesco Direct have yet to infiltrate that particular market..
He smirked and offered his hand to me.I knew it was a test.I rose to the challenge then feigned an excuse to depart to the kitchen to wash ones hands after failing to inconspicuously dislodge the damage onto the seat of ones
Surprisingly he was a double Southern Comfort and lemonade aficionado. Well blow me down with a feather, I didn't see that one coming.By the end of the evening, being well oiled and a tad unsteady on his steel toed boots,he stotted in a side to side motion down my previously buffed back passage steadying himself all the while on my newly painted Burnt Verdigris walls..Sadly a black smudge frieze on a wall doesn't do it for me.Thank gawd for Cif.
Then,last Saturday afternoon a middle aged couple approached the bar.Swarthy looking types, faint hint of a moustache.
Conversely the husband was clean shaven.Ordering themselves a couple of ales,they took a cosy seat by the fireside where the wife produced her KNITTING from a very large Tapestry bag then,proceeded to knit for the next hour and a half.Not a word was spoken.Now I wondered what the crack was with this, so I googled knitting and apparently these two are bang on trend as knitting is once again a popular pastime amongst the rich and famous.Though to be honest I cant see Gwyneth Paltrow sizing up a half finished garment to Chris Martins back in a pub..Truly not a sight one sees very often..
I don't regard myself as a city slicker,the Inn is undoubtedly in a rural location,but it is almost within spitting distance of a small market town.The New Pub locals regard *small market town*as the bright lights.We had to put the prices up(one has to make a profit) there's been a bit of opposition, feedback has been on the lines of: 'but them's *small market town* prices...'
I've been feeling like the landlady at Jamaica Inn,every time the front door opens I'm beginning to hear a howling noise as the wind blows,yesterday I swear tumbleweed followed a customer through the door.
'Its blowing a hoolie oot thar' says he.That's the other thing,its windy.All the time...
Today someone asked to order a *nosebag* and no it wasn't for his horse..
And men wear *strides* not trousers round these parts..
Anyhoo, apologies in advance that toilets/drainage seem to be a recurring theme,but yesterday we had another little incident.It appeared the water wasn't draining away from the upstairs loo.Following prolonged efforts with plunger and rubber gloves,still no joy.
I decided to leave it and returned to the kitchen to do some lone prep for lunchtime(following last weeks sacking).Ems Mum had kindly brought some duck eggs down from the farm so I thought I'd knock up some Duck egg and smoked bacon mayonnaise for the sarnie menu.They were so bloody fresh I was having difficulty peeling them and was muttering incoherently to myself when I felt a drip of water plop on my head.
To cut a long story short we had to call out an emergency plumber as the water was seeping through the joints in the soil pipe from the loo sited conveniently directly above the kitchen.
At £80 call out plus £40 for every 15minutes thereafter I was hoping the problem would be resolved quickly.
I left Ems to deal with the plumbers(dour chaps not much crack).Presently I heard excited shouts with my name interspersed in the din.
I ran from the kitchen with the half peeled egg still in my hand.
Plumber:'COME HERE YOU'VE GOT TO SEE THIS'
I gingerly peered down the manhole cover and witnessed a six inch wide solid mass slowly emerging from the waste pipe.
Ems was on the periphery of the activity whimpering,silent tears rolling down her cheeks.
Plumber:I've never seen anything like it,its this long(stretches arms wide at full length)at least ten feet,compacted right up the soil pipe,at least a couple of months worth there.'
He was quite animated unlike his demeanour on his earlier arrival.
Well at least someone had some job satisfaction..
From the comfort of his provincial though close to civilisation kitchen, with wall to wall hotcupboard,tattie rumbler and hot lamps,Chef was blissfully unaware of the dramas that were unfolding far off the beaten track.
When news filtered back to the ranch, the old text message to landline chestnut was called into play once again.
'Oh dear...there was a big fat sausage in the loo pipe'
I fear the lady from Masterchef is the only thing that's keeping us going at the moment...
Hard boiled egg anyone???


text:
Hi, I'm Ryan Stephens.
I am an entrepreneurial-minded business strategist passionate about solving complex problems, cultivating strategic relationships and developing solutions to drive measurable return on investment.
I started this site in 2008 with a goal of helping people use the Internet to grow their business.
For the last 10 years, I've worked behind-the-scenes to drive results for a breadth of organizations including: Fortune 500 companies, top academic medical institutions, seed-funded start-ups, division 1 universities, and a number of local businesses. (Testimonials)
Concurrently I spent a lot of time reading books, studying top performers (authors, entrepreneurs, business leaders and more) and sharing what I learned with the readers of this site.
In fact, every week I share articles and insights to help you level up your life — to become healthier, happier and more productive.
Ready to join countless others currently leveling up their lives and growing their careers?
My work and ideas have been featured in:
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- … And Some People like My Videos


text: solidThinking Continues International Expansion by Adding Sumisho Computer Systems Corporation as a Reseller in Japan Designers can obtain a product demo at the Design Engineering & Manufacturing Expo in Tokyo June 23-25 TROY, Mich. (USA) – June 18, 2010 – solidThinking, Inc. (http://www.solidthinking.com) has partnered with Tokyo-based Sumisho Computer Systems Corporation (SCS) (http://www.scs.co.jp/english/) to increase the adoption of solidThinking's 3D NURBS-based conceptual-design software throughout Japan and its surrounding regions. SCS is one of Japan's largest IT solution and service providers and is listed on the Tokyo Stock Exchange. "solidThinking is committed to serving and growing its global customer base, and our increasing number of reseller partnerships represents our dedication to supporting designers worldwide," said Jim Hassberger, solidThinking's vice president of business development and customer relations. "We value the strategic partnerships we have developed with SCS and other leading international resellers and look forward to continuing to diversify and expand our channel partner community." This agreement with SCS is the latest in a series of recent international value-added reseller (VAR) announcements for solidThinking. The company has rapidly extended its market presence through VARs in Belgium; Brazil; Canada; China; France; Germany; India; Italy; Japan; Korea; Luxemburg; Malaysia; Mexico; Netherlands; Portugal; Spain; Sweden; UK; and USA. "solidThinking provides an excellent complement to our wide range of product development solutions," said Amino, Hirotaka, general manager of SCS's digital design division, engineering solution unit. "We are pleased to have solidThinking as a partner in our effort to bring valuable new technology to aid our clients during the design ideation process. We are confident that we can successfully introduce solidThinking's software to our clients by utilizing our rich experience and strong expertise." Through its flexible, yet powerful, implementation of NURBS (non-uniform rational b-splines) modeling, solidThinking's 3D conceptual-design software encourages innovation in industrial designers who want the highest precision for any analytic or freeform shape. The software offers a best-in-class ConstructionTree™ technology that allows designers to experiment in real time, without starting from scratch, when they change their minds. solidThinking produces high-quality, real-time photorealistic imaging for realistic design visualization. With solidThinking Inspired™, users can apply morphogenesis™ form-generation technology to grow efficient shapes in response to environmental forces and pressures. Morphogenesis draws on the principles of biomimicry to allow designers and architects to use form generation to explore and experiment with design concepts. To acquaint current and potential clients in the Asian-Pacific region with the advanced features and benefits of its software, solidThinking will host free product demonstrations along with parent company Altair (www.altair.com), at the upcoming Design Engineering & Manufacturing Solutions Expo (DMS) June 23-25, 2010. Visit Altair's DMS booth 17-34 at the Tokyo International Exhibition Center for a hands-on demonstration of solidThinking and solidThinking Inspired. For more information, visit the solidThinking events calendar at http://www.solidthinking.com/forms/eventlist.aspx or the DMS website at http://www.dms-tokyo.jp/english/. "DMS is Japan's largest product development and manufacturing expo, so we are eager to display solidThinking's extensive capabilities to attendees, who can benefit from the software's intuitive design and high-quality imaging," said Alex Mazzardo, solidThinking's vice president of product strategy and marketing. "solidThinking's state-of-the-art rendering capabilities, visual effects and compatibility with other computer-aided design tools empower designers to explore more creative possibilities during the design process in less time and improve collaboration between designers and engineers." To connect with solidThinking, visit: solidThinking blog – https://blogs.solidthinking.com Facebook – http://www.facebook.com/solidThinking Twitter – http://www.twitter.com/solidThinking YouTube – http://www.youtube.com/solidThinking About Sumisho Computer System Corporation (http://www.scs.co.jp) Sumisho Computer Systems Corporation (SCS), founded in 1969, offers a wide range of system integration services to companies not only in Japan but worldwide. SCS aims to be in the first tier in the IT services industry, focusing on three strategic business domains: the industry-specific application business, which utilizes expert knowledge in each industry to customize system architecture to client needs; the ERP solutions business, which includes proprietary packaged software; and the platform solution business, which concentrates on IT architecture services for the creation of IT systems. SCS will provide your company with a service of trust and quality. For more information, visit http://www.scs.co.jp (Japanese) or http://www.scs.co.jp/english/ (English). About solidThinking, Inc. (http://www.solidthinking.com) solidThinking, Inc. develops and markets industrial design/styling software that helps designers invent, explore and evaluate new ideas easily, rapidly and cost-effectively, without the limitations of traditional software. Using solidThinking's conceptual 3D modeling capabilities, visualization interface and fast real-time rendering, designers can model, render and share their projects on the fly, from architecture and automobiles to electronic devices, jewelry, product packaging and yachts. solidThinking is a wholly owned subsidiary of Troy, Mich. (USA)-based Altair Engineering, Inc. (www.altair.com). Altair Engineering, celebrating its 25th year, is privately held and employs more than 1,300 in North America, South America, Europe and Asia/Pacific.


text:
Seongkook Heo and Jaeyeon Lee won NAVER 2016 PhD fellowship award.
NAVER PhD fellowship award is given to outstanding CS PhD students who have published top conference papers and journal articles.
This year, our lab have three NAVER PhD fellowship awardees including Sunjun Kim, who received the award this spring.


text:
Meet James, from Perth in Australia.
How long have you lived in Perth?
My whole life.
What's great about living in Perth?
The weather is beautiful.
Are there any downsides to living in Perth?
The nightlife isn't as fast paced as I'd like.
Where do you go out in Perth?
Leederville and Northbridge have some nice clubs and restaurants – you'll often find me there on a Saturday night.
Which is your favourite beach?
Scarborough beach.
Where do you go on vacation?
I love Bali, because it's cheap and a great place to relax.
How did you get into modelling?
I've always taken care of my appearance, so I thought why not take advantage of that?
What next for James?
Keep working on myself, and always be ready for whatever opportunities life sends my way.


text:
norayoung.ca | At the Corner of Technology and Culture
Book Details: Launch, Tour and Such!
——————————————- UPDATE: I'm very excited that the Third Tuesday Social Media series is bringing me to four of their upcoming events in cities around the country! Third Tuesday events bring together people – mostly in media, communications, and marketing, but also those just interested in social media – to meet up and stay on top […]
First Spark of the New Season
Today, we launch season five(!) of Spark, my CBC radio broadcast/podcast. You can listen to it online here, or subscribe to the podcast.


text:
Finished this book on the bus ride home…it was all I could do not to hurl my copy out the bus window into the downtown traffic. Here's my review on Goodreads:
Dead Souls by Nikolai V. Gogol
My review
rating: 1 of 5 stars
If ever there was a posterbook for not publishing unfinished works…this here book is it. Not cohesive, flat characters. Not a fan.
I think I'm going to take the weekend off…revel in my doneness…read some of Stone's Fall and I'll dive in to Ship of Fools come Monday.
On a side note…according to Wikipedia Porter won her Pulitzer, not for this novel but for a collection of her short stories. This was confirmed in Hilton Als' recent article about Porter in New Yorker. That makes the score Wikipedia – 1, Justin – 0 (that a goose egg folks!).
But this novel was the best selling book of 1962! (Also the Als article).
Until June,


text:
(adj.) Tense or concerned about something. Eg. "there's nothing to worry about so don't get~"
Related definitions:
Ducks in a row
(phr.) To be thinking well in advance of the current situation – for air and ground use. Ahead of the aircraft
Related definitions:
(v.) To be visibly and audibly distressed by something. cf. Faff, Rolling goat
Related definitions:
Hanging off the tailplane
(v.) To have reached the limit of one's mental capacity when airborne. Waterskiing behind the aircraft cf. Maxed outDefinition link
Head fire
(adj.) Fictional description of the brain actually catching fire due to input overload describing the point at which a person reaches their maximum mental capacity. Maxed outDefinition link
Make it Work
(Order) I don't know how to teach you this so just do it. BTAC
Related definitions:
Thinx bubble
(n.) Confusion cf. Maths in public
Related definitions:
Maths in public
(n.) Conducting a rapid calculation under pressure of examination. Usually said after the event, when the calculated figure was incorrect. cf. Thinx bubble
Related definitions:
Maxed out
(adj.) To have reached the limit of one's mental capacity. cf. Head fire, Waterskiing behind the aircraft
Related definitions:
No brainer
(adj.) Something that is relatively easy. Noddy cf. A-levelDefinition link
(adj) Simple or straight-forward. Piece of (old) piss, cf. A-level
Related definitions:
Off the top of your head
(adv.) Used to describe the production of an answer or estimate, instantly, without reference to any outside material. cf. Maths in public
Related definitions:
On fire
(adj.) Used to describe someone who is performing particularly well for the moment. The boy
Related definitions:
On top of things
(adj.) In total control of the current situation. cf. Ahead of the aircraft, Ahead of the drag curve, Ahead of the game, All over it like a (cheap) rash
Related definitions:
Running on rails
(v.) Having everything under total control. Sipping the Chablis
Related definitions:
Spammed (up)
(adj.) In possession of all relevant knowledge of a subject. Up to speed
Related definitions:
Switched on
(adj.) An alert and knowledgeable person.
Related definitions:
Waterskiing behind the aircraft
(v.) To have reached the limit of one's mental capacity when airborne. Hanging off the tailplane cf. Maxed out


text:
Located north of the Las Vegas Strip, within 1 mile of the Stratosphere Casino, Shalimar Hotel of Las Vegas features an outdoor swimming pool and on-site restaurant. All guest rooms include free WiFi.
A cable TV is offered in each room at this Las Vegas motel. An en suite bathroom is also provided.
The Florida Cafe Restaurant and Lounge, located on the property, serves Cuban cuisine. The restaurant is open for breakfast, lunch and dinner and room service is available.
A 24-hour front desk welcomes guests. Free parking is provided. Shalimar Hotel of Las Vegas features an on-site wedding chapel and meeting facilities
The Fremont Street Experience is only minutes from the property. Guests will also appreciate easy travel up and down the strip for a small, daily fee via the city's Double Decker bus.BOOK NOW
Visited 1022 times, 2 Visits today


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I can honestly say that 100% of the students in my class have become fully engaged in writing since the commencement of Boomwriter.
Mrs. Noakes
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text:
He shouts, "Doctor Dog! Doctor Dog!" as if he was the official welcoming party for the therapy animals that we have brought for the day's session on May 15, 2012.
John-John is among the better functioning boys at Cottolengo Filipino in Rodriguez, Rizal. The other boys remain bed or wheelchair-bound, their bodies slightly twisted and they are unable to verbalize how they feel or what they want. The caregivers know their moods and needs only by their familiar grunts and the slight changes in facial expressions.
Many of the patients eventually reach out to touch the dog and the corners of their mouths shift a little to betray a small smile. For those who are unable to change their facial expression because of their condition, the unmistakable light in their eyes show the volunteers and Cottolengo staff members that the 'therapy' is working.
"The idea of showing how dogs help humans and make them ambassadors for the animal welfare movement was just so fantastic that I said "yes" right away, "Lichauco reminisces. She had no inkling though that it was going to be so difficult to get into the hospitals who were very strict about allowing animals in the rooms.
This was why the Philippines' first Dr. Dog, a German Shepherd named "Pakko", started to do the visits at institutions like Tahanang Walang Hagdan (House Without Stairs – a home and school for specially-abled individuals in wheelchairs) and HOPE (a school for autistic children) before he and his pioneer group of canine 'medical practitioners' were allowed to eventually enter a hospital.
Dr Julius Lecciones, Medical Director of PCMC, had this to say about the furry doctors when they first came to visit the hospital five years ago, " The kids are happier when the dogs come to visit. We know that having a positive attitude during their treatment is also crucial to their getting well and that's what the dogs do to the kids," he said.
Dog 'doctors' present at the said PCMC visit were Poypoy (aspin), Bonita (Chihuahua), Kohler (schnauzer), Adonis (shihtzu), Eddie (labrador) and Ginger (pomeranian). Television crews from GMA 7 and TV5 were there to cover the event.
Dr Poypoy, one of the three aspins (Asong Pinoy or native dog) in the Dr Dog roster, also provides entertainment as he can jump through hoops, shoot mini-basketballs and catch frisbees.
"Although technically, therapy animals are not required to know any tricks," says Anna Cabrera, PAWS' Executive Director, who coordinates the visits of the Dr. Dogs.
Cabrera explains that the dogs go through a temperament test to determine if they are suited to be therapy animals.
Currently, PAWS has ten active Dr Dogs and the organization is still on the lookout for more applicants.
"If they think their dogs meet these requirements, we hope more aspin owners will consider applying their friendly, neutered aspins into the program," adds Nice Rodriguez, owner of Poypoy and President of the PAWS' Aspin Club – a club that seeks to uplift the image of native dogs.
"It changes one's whole perspective on animals when we see that it's not always about people helping animals.
"It really is, and pet owners swear by this, about animals helping people," says Cabrera.
Donations of toys, books and other items for giveaways at the institutions that the Dr Dogs visit are accepted at the PAWS Animal Rehabilitation Center in Aurora Boulevard, Katipunan Valley, QC during office hours of 10 am to 5pm, Mondays to Saturdays.
To apply for Dr Dog, send an email to email@example.com. To donate cash and support PAWS' humane education programs, please deposit at any of PAWS' bank accounts on www.paws.org.ph or through Paypal. We need your support to keep these programs running!
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Looking for tips on cloning e coli for complete Myostatin knockout expirament in near future
I've been interested in Myostatin gene deletion for some time. e-coli is the carrier for the human Myostatin knockout Targeting crispr cas-9 plasmid I'll be using, however the dna concentration in the kit is not high enough. Dna replication can happen if I can grow a larger e-coli culture. Anyone know the exact procedure for growing e-coli in a controlled fashion? Once I grow a suitable amount of the bacteria I'll be using an endotoxin free plasmid dna isolation kit to isolate the human Myostatin knockout Targeting crispr cas-9 plasmid. Once isolated it will be combined with polyethylenimine in order to allow delivery into the cells. Any information on how to grow an e coli culture would be greatly appreciated. My observations results and any other questions I have will be posted here once I can begin this expirament.
Well growing bacterial cultures is rediculously easy. Are you sure there isn't something like a selective medium though being used to keep the change? Like does the medium you're working with have an antibiotic in it?
Yes I've heard it's incredibly easy yet can find no specific information on it which is strange to me. The medium to my knowledge does not have and antibiotic in it and isn't a selective medium. I believe it is just contains the Myostatin knockout Targeting crispr cas-9 plasmid being carried in an e-coli culture. Would I be able to simply grow the bacteria culture on an agar medium? And is there any way I would be able to measure out a specific amount of bacteria to use from the culture once I grow it?
If you grow in LB broth instead of agar you can you a spectrophotometer to measure the concentration of bacteria in the broth
That's promising! There wouldn't be any reason I would be unable to filter out the lb broth using an endotoxin free plasmid dna isolation kit once i measure the e-coli concentration, right?
By the way the open human plasmid does have ampicillin resistance, so I would think the CRISPR-cas9 one does too. Maybe email the odin (assuming this is where you're getting your stuff).
Honestly I don't think you'd need to measure the concentration of bacteria in the broth/media. You're probably going for the most you can get, so you go for a large dose. Then kit should filter out the lb broth if it's what I'm thinking of. You would also likely want to do multiple doses. One dose of even high concentration and large volume would likely not be as effective as you expect. You may need to grow a culture, take a small amount and put it in broth/plate, inject yourself with the purified plasmid from the original broth, and repeat.
I would be very cautious with this. We now know that CRISPR seems to illicite an innate immune response. This may not be an issue for you on a physiological macro scale, however it may stop you from seeing any physiological changes post injection. There is also the chance of a severe allergic reaction to literally anything you inject into yourself. You would be wise to strongly consider this, what allergie you have, and whether you want an epipen/epinephrine and a partner.
I too wanted to modify my myostatin gene, however the way the Dr. Zayner does it is very crude to me and potentially not as effective as other methods. I decided against doing this in myself and want to warn against others blindly following what Zayner did because it's cool. On the other hand I also want to help anyone who wants to go forward with this procedure after learning about it. If any of you do want help with the process I am willing to assist you.
Yeah, I definitely realize there is a large potential for allergic reaction and possible adverse effects. For this reason I plan on beginning with small doses to monitor for signs of allergic and adverse reaction and slowly ramping up my doses and dose frequency. I also see what you're saying about going for the largest doses possible and repeating the treatment. My plan is to grow the culture to have a larger abundance of it. The reason I want to be able to measure how much I have is to know how much polyethylenimine to mix in to achieve maximum effective delivery into the cells. What other methods do you think would be more effective than this method? What makes you view this method as crude?
@RealityWizard I'm very interested in any other methods for accomplishing this you have discovered. I haven't found any other methods other than this one and have basically dedicated all my research into this particular method.
@TylerEyth You could try a virus. There are again issues with that especially with the immune system, but from what I remember it is generally more effective. Of course a virus comes with all the issues of working with a virus especially if it's particularly virulent. From what I can tell this method would introduce less errors and mutations. You would have to research this in particular, but it should be easy enough to get the genome of some adenovirus that's used for gene therapy and insert your own sequence that should be integrated into the host genome. I suppose this may be overcomplicating things.
There are also things like zinc finger nucleases and TALENS, but these are not as good as viral if I recall properly and they would take quite a bit of work. I'm also not sure you can reasonably use this in yourself.
From what I know your best bet is a virus or CRISPR. If you do CRISPR there is some documentation on it from Zayner, but I would encourage you to do research yourself. There is information on how to get CRISPR to target more effectively one spot. You may also want to make it so that the gene change is not a knock-out, but rather a nucleotide change that indicates decreased or loss of function. With the virus you should look into previous gene therapy trials and see how they performed it. there should be substantial material on this. No matter what there's a lot of reading to do. I suggest thinking of your goal in the situation and strongly considering why and how to make the change.
@RealityWizard my plan is basically copying Zayner's experiment as closely as I can, monitoring for adverse effects, and continuing to do treatments in sites all over the entire body and slowly upping dosage and dosage frequency and monitoring for visual changes in muscular structure as well as changes in muscle power output. I am trying to figure out a practical way to use systems in my body to disperse the CRISPR to avoid having to do site specific injections all over my entire body. Would a virus be able to accomplish this?
@TylerEyth Admittedly I do not know for sure. CRISPR is still being researched, so it may be hard to compare. However the efficiency of the virus to enter your cells would be much higher than the pure DNA+chemical that you would likely use for CRISPR.
I would avoid doing the whole body immediately. Start with small does on the forearms or calves. Somewhere well removed from the heart and brain. I would even consider using electroporation and possibly restricting blood flow with surgical tubing for a minute after injection. The reason behind this is to avoid any possible side effects. If you find yourself responding well to the treatment then go for more of the body.
Here is a good paper on viral vectors for gene therapy if you want to read it, but it may not help a lot (https://doi.org/10.1016/S0163-7258(98)00020-5).
I guess the easiest option is just using CRISPR and following Zayner. You may be able to improve the cas being used or use a different one entirely. Potentially one that has lower efficiency, but higher selectivity. I know in his page on the myostatin knockout he talks a little about his choice.


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Hotell i Stansted
Stansted ligger vackert ute på landsbygden med täta och snabba tågförbindelser till London och det charmiga Cambridge och dess universitet. De trevliga städerna Chelmsford och Southend ligger inte heller långt härifrån. På det prisbelönta Radisson Blu Hotel London Stansted Airport, slimmat i glas och stål, kan du få en god natts sömn inför ett tidigt flyg och dessutom äta frukost i lugn och ro eller komma i säng direkt efter en sen ankomst. Detta är det enda hotellet med en direkt förbindelse till Stansted Airport.
Stansted has been an airfield since 1943 but it wasn't until the 1960s that it was used for commercial passengers. Today it's one of the busiest airports in the UK and the gateway to hundreds of business and holiday destinations. There are more than 40 airlines using the terminal from low cost airlines like Ryanair to several private jet companies such as Harrods Aviation. The airport is a modern white structure with huge white legs – an iconic design by Fosters Associates - striking both inside and out.
If you're catching a flight from Stansted then the Radisson Blu Hotel London Stansted Airport has a great location. The hotel is connected to the terminal building making it the ideal place to have a stress-free stay before a trip or relax at the spa after your flight. There are several shops at the terminal including gadget and fashion outlets and you won't have to worry about food and drink while you're here either – the terminal has plenty of cafes and places to eat and drink and the hotel has three restaurants and bars so you can have a leisurely breakfast, lunch or dinner before strolling across the walkway to check in.
Stansted and the hotel are easily accessible for London, either by car just 40 miles away, or by train with the Stansted Express, which whizzes you into the capital in less than 50 minutes. If you want to explore further afield then the historic city of Cambridge is not far and the seaside town of Southend is an easy drive.
Stansted Airport has a great location in the pretty Essex countryside and close to London. Whether you're visiting for business or leisure we've picked a few top attractions you can enjoy during your stay.
- Just on Stansted's doorstep is Bishop Stortford and it's here you'll find the National Trust's Hatfield Forest National Nature Reserve. This is a real gem of the natural world and you'll enjoy some fantastic walks and bike rides through the 1,000 acres of forest and meadows, seeing ornamental lakes designed by Capability Brown, ancient woodland and wildlife on the way. The Site of Special Scientific Interest also has a fascinating eighteenth century Shell House in its grounds.
- Harlow is the nearest large town to Stansted and it's an easy place to dip in and out of cafes, independent art galleries, museums and relax in some peaceful green spaces. If you're looking for a bit of retail therapy outside the airport then Harlow has a large shopping centre with all the major high street brands.
- Visit London! Jump on the Stansted Express and you'll be whizzed to the heart of the capital where you can explore all day to your heart's delight. On the return journey you'll be dropped right back at the airport moments from the hotel door.
- It's no surprise that playing golf around Stansted is popular as the courses are both challenging and beautiful. Bishops Stortford Golf Course was inspired by the designs of James Braid and has a contemporary clubhouse and a gentle 100-year-old parkland course. Elsenham Golf Club and Leisure Centre is a smaller challenge with a nine-hole course and the complex has a gym and café and bar.
- Saffron Walden just 14 miles from Stansted is worth a visit and is one of Essex's top attractions. The medieval market town has seen farmers selling their wares since 1141. Today it's a pretty place to visit, have lunch and enjoy the beauty of its historic buildings. There are art galleries, a museum, Victorian gardens and a maze! You can reach the town from the airport by bus or train.
Stansted Airport has plenty of parking options for both short and long stays but the Radisson Blu Stansted Hotel has some great deals you can take advantage of too.
The Dream & Fly Stansted Airport Parking package offers parking and accommodation. You can choose from four days parking with one night accommodation (prices from GBP 134), eight days parking with one night accommodation (prices from GBP 159) or 15 days parking and one night accommodation (prices from GBP 179).
The hotel can also offer secure airport parking for 200 cars. Parking is charged at GBP 12 per night for hotel guests. Additional parking for non-residents is GBP 33 per night.
We also offer a valet service so that you can pick up your car all shiny and new after your trip.
The airport has Long Stay, Medium Stay, Short Stay, Meet and Greet and Valet Service options too. See the airport parking information for more options but remember the hotel is connected to the airport and the easiest and most convenient place to park during your stay.


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Haircut #1 is in the books. We made the hour and a half trip towards Em's parents. We decided to get Adler's hair cut by the same guy that has cut the family's hair for generations. He cut Adler's great-grandfather's hair; his grandfather's (Pappy) hair, Em's brothers, our nephews and now Adler.
It's a small town barber shop with the barber pole, the old fashioned chairs, and a bunch of guys sitting around gossiping more than cackle of women at a Tupperware party. It's one of the few places where you can still get a straight razor shave.
Adler did fine. He got a little tired of me holding his arms but overall it was great.


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Bernie Sanders met with President Obama in the Oval Office yesterday for over 45 minutes. In a press conference after the meeting, Sanders first emphasized the importance of a large voter turnout at the upcoming Iowa caucuses. He said that if there is a large turnout he think's he will win, but if not, the campaign will struggle. Sanders added that the American people want to see real change in this country and that his campaign is "tapping into that energy." He then delved into speaking about his meeting with the president.
Bernie Sanders' foreign policy meeting with President Obama was intended to reestablish presidential neutrality: https://t.co/6FSO6GUW0C
— New York Magazine (@NYMag) January 28, 2016
Sanders said the meeting was "productive and constructive," and that they talked about "a number of issues." Among the topics they discussed were foreign policy and domestic issues, and "occasionallya little bit of politics."
On the topic of foreign policy, Sanders explained how he agrees with the president's actions. "What he is trying to do is keep our young men and women in the military out of a perpetual war in the quagmire of the Middle East," he said. "What he has tried to do, what I will try to do. is put together a coalition of the major powers, with the Muslim people."
When asked whether or not Sen. Sanders asked for the president's endorsement, he replied, "No. Of course not." When President Obama was a senator, he campaigned for Sanders in Vermont, something Sanders said he has "never forgotten." However, the Senator and President do not agree on every issue. "I was on the floor of the senate for eight and a half hours in disagreement over taxes. We disagree over the TPP," Sanders insisted. Overall, he said that he has stood by the President's side as he's taken on "unprecedented Republican obstructionism and has tried to do the right thing for the American people."
The White House did not provide details about the private meeting, however Press Secretary Josh Earnest said that the tight race is good for the country. "It's good for our democracy," he said. "It's also good for the party."
What do you make of Sen. Sanders' meeting with the President? Do you think it will help his numbers in Iowa? Let us know in the comments below!
-Bronte Price
The views and opinions expressed herein are those of the author's alone and do not necessarily reflect the views of Ora Media, LLC, its affiliates, or its employees.


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