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This week and next, SpotOn is publishing a series of blogs on how to use social media for science outreach. Each day will look at a different set of themed case studies, submitted by scientists and science communicators.
According to the SpotOn website, the schedule is:
- Tuesday: multimedia projects–using tools such as podcasts, videos, G+
hangouts and tumblr
- Wednesday: blogging for a research institution or other science organization
- Thursday: blogging and using social media as an individual scientist
- Friday: using Twitter–at conferences, for journal clubs and more
- Monday: one-off social media
activities–such as raising awareness of another project
You can also participate in discussions on Twitter, using the hashtag #reachingoutsci, or by attending the panel event in New York City tomorrow (SpotOn NYC's second birthday!).
SpotOn is a series of community events hosted by Nature Publishing Group for the discussion of how science is carried out and communicated online.
– Ann L. Whitman


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Electrophoresis Equipment Not Required
This Program is a complete laboratory course for teaching cell and molecular biology at the college level. The program is designed for 16 students working in pairs and provides essentially all of the chemicals and instructions that are needed to teach sixteen 3 hour laboratory sessions. The course consists of 16 experiments carefully selected from 7 Laboratory Programs that are presented in a comprehensive integrated laboratory manuals. The Table of Contents of the manual and the catalog numbers of the experiments provided with the program are shown below.
Telephone 1-765-446-4220
Fax 765-446-4225
Postal address:
2211 South St.
Lafayette IN 47904

subset: commoncrawl


text:
Nutrition Now PB 8, Probiotic Acidophilus, Vegetarian120ea
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**14 Billion good bacteria per serving at time of manufacture. Bacteria count will vary after time of manufacture.
As a dietary supplement for adults, take two (2) capsules per day. Store in a cool, dry place; best if refrigerated.
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'Name the Character' Mega Giveaway!
January 24, 2017 – February 21, 2017
Win the Grand Prize Swag Bag or 1 of 20 eBooks!
Okay creative types, now is your chance to name a character in my upcoming art mystery, The Anthropologist (working title), and see your own name immortalized in the book's acknowledgements!
The entrant with the 'best' name wins an extremely cool Grand Prize swag bag:
- Signed paperback copies of The Lover's Portrait and Down and Out in Kathmandu (the first two books in the Adventures of Zelda Richardson series),
- Sunflowers mug from the Van Gogh Museum gift shop,
- Bicycle-shaped bookmarks,
- Treasure Map of Amsterdam and
- Prayer Flags made in Nepal!
- In addition, you will receive TWO autographed paperback copies of The Anthropologist, as soon as it is published (expected release date November 2017)!
Name the Character: Who is She?
In The Lover's Portrait: An Art Mystery, Zelda's best friend Friedrich, a Swiss psychology student, had no luck with women. In The Anthropologist, he's met the love of his life: a beautiful, caring and smart fellow psychology student. Only problem is, she hates Frederick's female friends, including Zelda.
What is her first and last name?
Enter your answer as a comment to this post here on my blog, on my Facebook Author Page or Goodreads blog.
Only one entry per person, so make it a good one!
Even if you don't win the 'Name the Character' contest, I've still got you covered. I'll also randomly select TWENTY entrants to win ONE eBook copy of either The Lover's Portrait or Down and Out in Kathmandu (winner's choice), to be gifted to you from Amazon or Smashwords!
For those who want to win a book but don't want to think up a character's name, tell me the name of a country you'd like to visit and I'll enter you in the eBook contest.
Synopsis of The Anthropologist (Adventures of Zelda Richardson, Book Three):
Zelda Richardson's back and embroiled in another exciting art mystery! This time she's working at the Tropenmuseum on an exhibition of bis poles from the Asmat region of Papua New Guinea, the same area where a famous American anthropologist disappeared in 1965. When his journals are found inside one of the bis poles, Zelda's tasked with finding out more about the man's last days and his connection to these ritual objects.
Zelda finds herself pulled into a world of shady anthropologists, missionaries, art collectors, gallery owners and smugglers, where the only thing that is certain, is that the sins of the past are never fully erased.
Join Zelda on her next quest as she grapples with the anthropologist's mysterious disappearance fifty years earlier, and a present-day murderer who will do everything to prevent her from discovering the truth. Art, religion and anthropology collide in my upcoming art mystery thriller, book three of the Adventures of Zelda Richardson series! Expected release date November 2017.
Thanks for playing and have fun!
Please like my Facebook page, follow me on Twitter or sign up to receive notifications of new blog posts here on my website (the sign up form is in the right-hand sidebar). That way, you'll know immediately if you won a prize! This is not required, but greatly appreciated.
Rules to keep it fun (by entering this contest you agree to the following):
- Only one entry per person. Enter by commenting on the 'Mega Giveaway post' on my Facebook Author's Page, Goodreads blog or website's blog.
- Contest closes at on February 21, 2017 at midnight EST.
- You must be 18 years or older to participate.
- Anyone in the world is welcome to play (no country restrictions).
- Once I've assigned your entry a number, your response cannot be changed.
- No obscene, erotic or hateful names. Any inappropriate entries will be deleted and the entrant banned from re-entering.
- Prizes cannot be exchanged for money or any other form of compensation.
- I have the right to use the chosen character name freely. The winner does not retain any rights of any kind, in association with the use of the character's name, physical description or nationality. The winner will not be compensated for its use in any way, other than the aforementioned Grand Prize. This is for fun, not profit!
- I will personally choose the winner of the Grand Prize, based on the character name I think is best.
- The Grand Prize winner agrees to allow me use their full name in the Acknowledgements of The Anthropologist (working title) and their first name in promotional social media posts.
- In order to select the 20 winners of a single eBook, I will assign each entry a unique number during the contest. The day after the contest closes, I will use a random number generator to choose the 20 winners.
- Winners of all prizes will be contacted via the email address or Facebook username they used to enter.
- The Grand Prize winner's Swag Bag will be mailed via standard delivery from Amsterdam, the Netherlands to the winner within three days of confirming his or her postal address.
- The 20 eBook winners will be asked to choose ONE eBook (either The Lover's Portrait or Down and Out in Kathmandu) to be gifted to them via Amazon or Smashwords (compatible with Kobo, Apple, Nook, Android, Sony and Kindle readers).
- Prizes not claimed by April 4, 2017 will no longer be awarded. Be sure to check your email and FB messenger accounts on February 22th to see if you've won!
Synopsis of The Lover's Portrait (Adventures of Zelda Richardson, Book Two):
When a homosexual Dutch art dealer hides the stock from his gallery – rather than turn it over to his Nazi blackmailer – he pays with his life, leaving a treasure trove of modern masterpieces buried somewhere in Amsterdam, presumably lost forever. That is, until American art history student Zelda Richardson sticks her nose in. Read an excerpt now on Amazon.
Synopsis of Down and Out in Kathmandu (Adventures of Zelda Richardson, Book One):
An idealistic backpacker volunteering as an English teacher in Nepal finds herself entangled with an international gang of smugglers whose Thai leader believes she's stolen their diamonds. Read an excerpt now on Amazon.


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Nigeria Is Our Biggest Market –Mafikizolo
Mafikizolo is a South African singing duo consisting of Theo Kgosinkwe and Nhlanhla Nciza. They are three-time winners of the South African Music Award for Group or Duo of the Year. Their compositions include songs in various South African languages such as IsiZulu,Isixhosa, English And Afrikaans. In an interview with select entertainment journalist at the Dome Abuja, the duo speak about their music, style and latest album. ANTHONY ADA ABRAHAM was there for LEADERSHIP.
Your performance was electrifying tonight, is this your first time in Abuja?
This is actually our second time. Its been a while.
So how do you feel being in Nigeria today and performing at the Dome Entertainment Centre?
It feels good! We love Nigeria and we are happy that we are givenbthe opportunity to come thrill our fans. We've been to Abuja, Lagos, Port Harcourt, Bayelsa. We also did Calabar carnival. We have been to many places across Nigeria because we have many artistes from Nigeria we have done collaborations with. The likes of May D, Davido , DJ SPINALL, we did something with Yemi Alade recently. We also did something new with Wizkid as well. This is home for us.
How can you describe Nigerians because you might have another impression of us anytime you are coming into the country, how are you treated?
This place is always home because the first time we came here it started from the immigration. Before we even entered the checks you hear shouts from various angles , people shouting out names , wanting to take photographs with us. Nigeria is the biggest country in Africa and we have gotten amazing response from them. We are one of the South African artistes to have introduced Nigeria young artistes to do collaborations with other south Africans artistes. Nigeria is our biggest market.
What should we be expecting from you soon?
We did a collaboration with Jah Prazer from Tanzania. We will also be shooting the musical video. After that we will be shooting the musical video we did with Wizkid. Yeah there is a couple of collaborations we did. We will be dropping like 5 videos.
You always come out very nice, so how would you describe your style?
We mix African culture with Western culture because we are trying to encourage the south African young people to wear African attires with pride by mixing the African culture with the western culture. It becomes easier for them to start picking African attires.
Do you design your outfits?
Yes I do. I have a clothing label called LL Vintage all about making people looking beautifully African.
What do you think about Nigerian Fashion?
I think it is amazing! Because whenever I look at the Nigerian fashion week, I say to myself that we still need to grow back at home because the designers here are just too amazing. I know many celebrities back home that have worn amazing designs by some Nigerian designers. I have seen the red carpets in Nigeria and how the ladies look on it and how people take African fashion to another level. So much respect.
Has collaborating with Nigerian artistes has any impact on your music, because you started quite early?
Flashback to 20years ago, our music was well known but I think collaborations takes your music to different level and different places and audience that you never had. Our collaboration with Davido opened up the Western market for us to Nigeria and the whole continent. We will continue to collaborate with different artistes from different places. Collaborations introduces us to their market and them to ours. If we work together, then we can be able to fuse different audiences to meet the yearnings of our fans.
So what should your fans in Nigeria expect from you next?
We just want to say our album is out , you guys can download it. It has got amazing features and collaboration like DJ Maphorisa, we also have Master Craft on the beat with Yemi Alade on one of the tracks. We've got Wizkid on a track, also Selina Johnson, she an acclaimed international artiste. We've got Jah Prazer from Zimbabwe, Harmonize from Tanzania .So if you want a good and a great album, check ours out. We have been nominated for 6 awards in South Africa. 'Love Portion' is almost on 10Million views now. To our fans in Nigeria continue to support us as much as you supported us when we did "Kona". We want our biggest selling market to come from Nigeria.
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Pakistan vs England (2nd Test) 23 July 2016
Pakistan vs England (2nd Test)
The First day of the Second Test ended with a big chance for England to get revenge of the big defeat at Lord's. They ended the day 1 with 314-4 where the captain led his side from the front and scored a magnificent Hundred also the most reliable batsmen of the team Joe Root supported his captain a lot and he is still batting at 141 not out. From Pakistan it was looking as they forgot the basics and couldn't do much as people were expecting from them. 4 drop catches, Fragile bowling and many were the reason as they couldn't perform much on the first day. Muhammad Amir and Rahat Ali both took 2 wickets and gave Pakistan some hope that quick wickets in early session can give them a chance to fight back.
Starting from Pakistan where on a batting Paradise wicket the bowlers also struggled a lot and some drop catches caused a lot of harm to the bowlers. None of the bowler couldn't do much except Amir and Rahat who both took 2 wickets. The Leggie Yasir Shah bowled 31 overs but couldn't get his very best which he was expecting in the match. Now Pakistan is in a sort of Pressure as the bowlers needs to use the morning conditions very well and they have to wrap up the English team as soon as they can. Conditions are quite favorable for batting and Pakistani batsmen have to mentally strong instead of taking pressure of a big trail. Pakistan no doubt has a batting line up which can tackle because 6 of their batsmen have 40+ average and are in top 30 rankings. So they just don't need to be panic and keep them calm and use the conditions well.
Coming towards the English side who will be happy after the first day but still a lot of work left to level the series. Their batsmen have done a great contribution but still they will be aiming about 450-500 to get Pakistan under pressure and then they will try to get them out in both innings. England have Anderson and strokes back and now they have a very strong bowling attack but still the conditions are quite good for batting so they have to bowl at very decent line and length to get Pakistani batsmen. Overall England has put Pakistani side under pressure but still if they got out cheaply tomorrow that will release the pressure from Pakistan and they will bat with cool and calm.
Conditions for the second day are quite favorable for batting and a very sunny day is expected but not for the 3rd and 4th day so let's see in which direction this test match goes.


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Underneath the silver birch
They'd hang pink with pleasure,
Blushing blossoms
Full and frothing.
Beneath the birch's lolling leaves
I'd read, or sing or dream,
And look through dappled light
To pale bare skies
Where contrails paint across the blue.
Small fingers fashioning necklaces
From a constellation
Of crimson-tinged daisies
Dotted on the lawn.
The smell of earth, damp and raw,
Grass-stained knees and the tantalising
Whispers of summer on the breeze.
I'd lie beneath those verdant boughs
Embraced in their beauty.
And even today,
When years have passed,
I'll smell the flowering redcurrant
And remember,
And smile.
A childhood memory, by Angela Barton


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All posts tagged "Rihanna"
Hear PARTYNEXTDOOR's 'Work' Demo
Unless you have been able to avoid listening to the radio, watching late night TV,FIRST LISTENApril 28, 2016
Rihanna Releases Hazy "Needed Me" Video
4/20 wouldn't be a proper "holiday" without a new Rihanna video, right? Today, the ANTIIN VIDEOApril 20, 2016
RECAP: Five Best Moments of Weekend One at Coachella
If you missed out on the first weekend of Coachella, don't worry -- we brought5SpotApril 18, 2016
Rihanna Set To Star in Her Own "Unfiltered" Documentary
Rihanna has been making some serious power moves over the past few months, releasing herNEWSWIREApril 13, 2016
Rihanna Shares "Kiss It Better"
We caught wind of Rihanna's "Kiss It Better" video yesterday, and as promised, today itIN VIDEOMarch 31, 2016
Rihanna Shows Video Teasers for "Kiss It Better"
Undoubtedly, "Kiss It Better" is one of the most noteworthy tracks on Rihanna's latest album,NEWSWIREMarch 30, 2016
Stream Rihanna's Hilariously Adorable Lullaby Album
Rihanna can be a bad bitch... and also have a soft side. Rockabye Baby just provedRE-BLOG'DMarch 24, 2016
Watch Rihanna and Drake perform "Work" at 2016 BRIT Awards
In case you missed it, Rihanna and Drake shared the video for "Work" yesterday --RE-BLOG'DFebruary 24, 2016
Rihanna and Drake Share Seven Minute "Work" Video
In a seven minute clip of a hazey night, Rihanna and Drake take you throughIN VIDEOFebruary 22, 2016
Rihanna and Drake Tease "Work" Video
Today, Rihanna has shared a 30-second clip of her video for "Work," featuring none otherRE-BLOG'DFebruary 19, 2016


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Back from PyData 2017 London2017-05-08 00:00:00 +0000
Back from #PyData2017 London where I gave a talk called "Show me the failures!", showing how the Data Science and Analytics team at Pirelli approach the problem of designing and implementing data products at shop floor.
Thank you again to all the crew, you guys have been amazing: venue, food, schedule were absolutely spot on. Bring it on and looking forward to coming over for #PyData2018! Here a link to the slides and below outline of my talk.
The Data Science and Analytics group at Pirelli has to deal with factories' day to day that can't be further from the aseptic crunching of data from a keyboard in an office. Our group took the lift, went down at shop floor and started asking questions to try and make their life better: turns out questions flowed the other way round and results were startling.
Pirelli has a 140 year old tradition of manufacturing with 20 factories across 14 countries and headquarter office in Milan. Production flows, logistic, machinery and the whole extended value chain has morphed through decades across a broad range of needs and circumstances.
The creation of a Data Science and Analytics department at the beginning of 2016 has the goal of speeding up change and innovation, starting from areas that are harder to tackle. Some of the most interesting challenges include:
- bring data products at shop floor to increase efficiency while being aware of UX principles
- keep 2-sided communication alive with wide number of actors, particularly with IT, quality and engineering
- encourage active participation by providing accessible analytics tools and an internal Academy training program
- activate the virtuous circle of prototyping, feasibility check and production releases for sound product lifecycles
- introduce Agile development methodologies in traditional waterfall environments
- shape a roadmap with principal stakeholders starting from off-line through live analysis and heading to ahead-of-time predictions
opening a steady communication channel across groups is progressively eroding barriers between white and blue collars, allowing teams to better understand each other requirements and kicking off a broader conversation. At the end of the first year since releasing the first prototype, there is much more on the plate, and groups are now more familiar with concepts of User Experience, release lifecycle, data exploration and agile development.
In this talk we are going to show the data science team approach to prototyping and implementation of data products for Pirelli factories, both at shop floor and quality / engineering offices. Different needs or - taking a UX approach - different personas, lead to different outcomes: from large displays mounted in wide warehouses to detailed descriptions of statistical distributions, from near real-time processing of streams of data coming out of sensors to large computations for statistical models made on millions of rows stored in sql tables.
The sheer variety of technologies involved in the process is probably the biggest challenge when deploying at production level: aside standard data processing and machine learning packages, such as Pandas and scikit-learn, our Flask and Django based web infrastructures interact with MsSQL servers, JBoss data virtualisers, a Hadoop cluster and Oracle data warehouse, responsively adapting their output for different contexts with Angular and React front-ends.
The introduction of data products has triggered a little revolution allowing to improve and widen the offer of internal training via an Academy program, in search of competences inside the factories for all people willing to open an editor and write some Python and Javascript.
P.S. link to a gist with my notes from the conference here


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So it's all over for us. As the eyes of the nation turn west- and south-ward, Philly can ditch the political drama and go back to plain old murder and mayhem, right? Not quite. The Theater Alliance of Greater Philadelphia's listserv was burning up in the weeks leading up to the primary, and now, in some sort of exquisite water torture for liberals, the vicious debate will be laid out onstage for all to see Saturday, May 3, 8 p.m. at Second Stage at the Adrienne.
A few things astonished me about this heated back-and-forth.
- First: there are conservatives among drama professionals, like, real red ones. Though I can't quite figure out what could possibly be in it for them other than an inherited bias, they are vehement and as convinced of McCain's relevance to their lives as any hedge fund trader or military engineer.
- Second: People actually "went there" on Clinton, making pantsuit jokes and the like. Theater people. And I don't think these posters were even the gay ones, who could get away with it.
- Third: No one really wanted to go there on Obama, which, I guess, is at least one positive sign. Maybe we can credit Rev. Wright for serving as the receptacle for this contest's racial enmity and diverting it from the candidate himself. This effect even seems to have spilled over into the real world. Remember in New Hampshire when those dudes yelled, "Iron my shirts!" at Hillary? We never saw a corollary pair of douchebags running around in blackface at an Obama rally (I'm sure they were somewhere, of course, just not out in public). So thanks, Rev. Wright, at least for that.
- Fourth: The listserv's, er, discussion had remarkably little to do with the candidates' relationship to the arts, which was, to me, distressing. There was even a brief flare-up about abortion, but nothing, NOTHING about the issue that most directly affects everyone on TAGP's e-mail list. Business-owning republicans won't shut up about taxes; shouldn't arts professionals be slightly concerned about their candidates' approaches to arts and education? Hello? Anyone?
- Fifth: Show folk will find an excuse to argue about almost anything.
I'd love to see the Second Stage event used as a means to discuss the issues surrounding our careers and the candidates' potential effect on them, or perhaps to galvanize the theater community into advocating that the arts and arts education take, if not center stage, then at least a supporting role during this political season–something I'm hoping every listserv member can agree upon. Though rehashing the old political divides will no doubt provide the same entertainment value once offered by the Romans to their people in the form of bears and slaves, moving forward with a November game plan has far more to do with creating an actual theater alliance.
Filed under: arts, culture, drama, media, Philadelphia Inquirer, Philly drama queen, theater, Theatre, writing | Tagged: arts, clinton, culture, drama, obama, pennsylvania primary, Philadelphia, Philadelphia Inquirer, tagp, theater, theater alliance, wendy rosenfield |


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Welcome to the Dundalk SDA Church in Dundalk, MD. We are a Christian community and would love to have you join our family. To learn more about what we believe you can visit our About Us page. Please join us for Bible study, worship, and prayer.
Pastor Anibal Lindo Hansell
Dundalk SDA Church
Join Us This Saturday
Service times:
Sabbath School: 9:30 am
Worship Service: 11:00 am


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Teddy and Harley are two very special little dogs who were rescued from the terrible conditions that exist in puppy mills. Often, puppy mills are the primary suppliers of pet stores and ads selling "purebred" puppies for hundreds of dollars. But sadly, despite the high price-tag, the conditions in which these puppies are raised are anything but top-notch,
Puppy mill dogs spend their entire lives in tiny, filthy cages with no medical attention, and many of them suffer from skin, eye, and dental diseases. Breeding dogs will never leave the facility and the profits from the sale of their puppies only go back to the cruel humans who hold them captive. Unfortunately, life for the puppies isn't much better as most end up suffering from health and behavioral problems, no matter how much someone paid for them. And yet, despite all this suffering, many people are still unaware that puppy mills even exist and continue to purchase dogs from pet stores entirely oblivious of the cruelty they are funding.
This is why the work of National Mill Dog Rescue is so important.
Meet Teddy and Harley, two former mill dogs – both saved by National Mill Dog Rescue – who have made it their life's mission to raise awareness for others like them!
This amazing organization is fighting tirelessly to rescue, rehabilitate, and rehome dogs that they find living in heartbreaking and inhumane puppy mill conditions. Some of them, like the two dogs pictured above, stand out because of particular hardships that they have overcome. Teddy was completely terrified of people when he was rescued and would growl at anyone who came near him. But with time and dedication, he was finally able to regain his trust of humans and has become the face of puppy mill awareness.
Poor Harley has a slightly different story, as the horrific conditions he endured while in a puppy mill ended up costing him his eye! He has also learned to trust again and has even appeared on the cover of Modern Dog magazine. Without the intervention of the National Mill Dog Rescue, neither one of these sweet fellas would have ever had the opportunity to experience the love of a human, but since their rescues, these two little hero's have become ambassadors for rehabilitated doggies everywhere.
Seeing these little guys in their capes reminds us that anyone can be a hero for animals! All it took was for kind people to step in and take these pups out of their former lives to inspire this entire movement.
If you would like to help the National Puppy Mill Dog Rescue in their life-saving mission, visit their website.
Image source: National Mill Dog Rescue


text:
MSNBC'S Howard Fineman is reporting that Ashely Judd has decided to run and will announce her candidacy for the U.S. Senate this May.
Visit NBCNews.com for breaking news, world news, and news about the economy
Actress Ashley Judd, who has reportedly been exploring a Senate run since last December, will announce her candidacy in the spring, MSNBC's Howard Fineman reported Sunday. Her candidacy would pit her against Senate minority leader Mitch McConnell.
Politics Feminist News Gender


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SRP-4045 is an investigational compound being developed by Sarepta Therapeutics to treat Duchenne muscular dystrophy (DMD) patients with mutations amenable to skipping exon 45 in the DMD gene.
How SRP-4045 works
DMD is a rare, life-shortening genetic disease, mostly affecting boys, that causes their muscles to break down and lose strength over time.
It is caused by mutations in the DMD gene. Most commonly, one or more exons (a portion of the gene) are missing, and the remaining exons do not fit together properly. Because of this error, cells cannot make the dystrophin protein that muscles need to work properly. Without dystrophin, muscle cells are damaged, and, over time, are replaced with scar and fat tissue.
SRP-4045 works by using Sarepta's proprietary phosphorodiamidate morpholino oligomer (PMO) chemistry and exon-skipping technology. PMO directs the cell to skip exon 45 when processing RNA (a molecule that ultimately leads to the production of a protein). Skipping a specific exon allows the body to make a shortened but still functional dystrophin protein.
By addressing the underlying cause of DMD and promoting the synthesis of a shorter dystrophin protein, SRP-4045 intends to slow the decline in the ability to walk and move seen in DMD patients.
SRP-4045 in clinical trials
The safety, tolerability, and pharmacokinetics of SRP-4045 are being evaluated in a randomized, placebo-controlled dose-adjustment Phase 1 study (NCT02530905). About 12 patients with advanced-stage DMD and deletions amenable to exon 45 skipping are enrolled.
A separate study is set to evaluate the efficacy and safety of SRP-4045 and another exon-skipping therapy, golodirsen or SRP-4053, in about 99 boys, ages 7 to 13, with DMD amenable to skipping exons 45 or 53. It is currently recruiting patients at test sites across the U.S. and Europe, and in Canada and Israel.
In this Phase 3, double-blind, placebo-controlled, trial (NCT02500381), called ESSENCE, patients will be randomized to receive either treatment or placebo as a once-weekly intravenous (IV) infusion for up to 96 weeks. This will be followed by an open-label extension period, in which all patients will receive open-label active treatment for up to 96 weeks.
The study's primary outcome will be changes in muscle strength from study start (baseline) as measured by changes in the six-minute walk test. Secondary goals include changes in dystrophin protein production and respiratory strength (measured by forced vital capacity, or the amount of air that can be expelled in one forced breath).
Muscular Dystrophy News is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.


text:
Ares Corporation Special! This is the biggest episode yet. This one has it all. Huge paydata, corporate history, the major players, the current events, and how this corporate monstrosity changed altered Opti's life forever. Don't miss this one, crows! Click below to listen to the Ares Corporation Special or go to future Ares Subsidiary iTunes, or various other podcast apps on your commlinks and Subscribe!
11 thoughts on "Ares Corporation Special"
This info was gold, thank you runner.
I got your back chummer. Anyone who hurts my crew will regret it.
I'm sorry to hear of your loss. Since I'm still on a job in ANZAC land until their Red Poppy commemorations start, I can't help directly. But I sent some of my job's advance nuyen to you via your secure funds site along with some pay data I ran across. It's definitive proof there were awakened creature sightings prior to the alleged first one in Japan. This particular picture is encoded with data to prove time and place – to the chagrin of the younger critter in the photo. Apparently this one couldn't restrain a taste for mutton. A tourist caught him in the act. Small change I know but it may come in handy.
It's pathetic to we who remember it clearly how the memory of the grand old United States of America and what it stood for is reduced to a pathetic, one dimensional, evil little militaristic drek stain that is Ares Technology. As if it is the old republic's sole endowment to future generations. Take care and keep your head on a swivel.
Hey Opti,
I'm in. Hell it's good to have a "cyberzombie" on your team, right? (Stupid Ares goons think I'm a cyberzombie.)
Make no mistake, Ares. It's not revenge. It's a reckoning.
Chummer. I won't sit here and lecture you on how running the shadows has risks. Nor will I lecture you about how revenge is a fools game, nor will I remind you that going against a Mega is a suicide run, or as that wise old 5th world philosopher Murphy says "If it can go wrong it will go wrong", and the 6th world addendum "Unless its a Mega then it goes wrong twice as often" Because Omae, I would probably do the same if I were in your shoes, I was always a sucker for a tragic love story, and I love causing havoc for a Mega. Besides what self respecting neo-anarchist would just sit back and do what others told them?
The way I figure it I probably how my life to you more than a few times over. More than once I have found myself in a bad situation only to dredge up some half remembered piece of data that I heard on your matrix broadcast that enabled me to get out of said situation.
So the way I figure it, I have been living on borrowed time that, truth be told (and it must), I borrowed from you. So if you want my help just let me know. I will send in a separate message instructions on how to contact me. I want to help. I have some juicy paydata on a few of the Ares Johnsons that operate in Seattle (the kind that they would do anything to not let out) that I have been hanging onto in case it came in handy, so I may be able to point you in the right direction for finding the runners that this "Dr. No" (what kind of bulldrek name is that anyways?) may have hired.
Let me know Chummer. I've had a good life and while I would love to go on living it, I figure if I am going to go out it might as well be for causing some havoc for a Mega and paying back a chummer, even if that chummer didn't even know he was owed. Besides if I can help Opti stay on the air then it will be worth it. What future intel might you broadcast that could save me in the future if I survive. Also I owe a debt to your totem and this might help me clear then board with Him.


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I put this in another thread - then realized it should be here
Borax as a catalyst
I put this in another thread - then realized it should be here
Borax as a catalyst
Alternatives to Baking Soda as a Catalyst
1. Sodium Citrate which is basically citric acid - a SAFE food ingredient used in ice cream, cheese and wine. Find it on eBay Store "The Chemical Connection" ($3.99) or locally - try the local winery or ice cream factory. Might be called Citrosodine, Tri-Sodium Citrate, Citric Acid (PURE citric acid, no sugar please!), or Tri-Sodium Salt.
2. Washing Soda is a laundry detergent that might be found under the names Soda Ash, Laundry Soda, Sal Soda, or Sodium Carbonate. Used as a non-toxic all-purpose cleaner - look in the laundry section of your grocery store.
3. Borax is also used for laundry and might be known as Sodium Borate, Sodium Tetraborate, or Disodium Tetraborate.
Although non-dangerous in general, Washing Soda and Borax might be toxic if swallowed. Keep away from children!
So I am reading this but I don't think the citric acid would work because I may be 100% wrong but don't we need a high alkaline solution? Citric acid would make it acidic correct?
Dancer, electrolyte can be either alkaline or acidic. I still think that you can not beat NaOH (lye). There is more to electrolyte than just its ions.
"Democracy is two wolves and a lamb deciding what to have for dinner. Liberty is a well-armed lamb."
ONE Liter per minute per 10 amps which just isn't possible Ha Ha .
That's why I thought I would be wrong. Just trying to learn cause the main systems I have seen use alkaline electrolyte.
Also MyoldYourgold whats your name? Also thanks for chasing me around this forum to correct my misinterpreted statements. I really am trying to learn this and have been trying to do more research before typing. LOL.
Last edited by danser75; 01-16-2012 at 05:42 PM.
I prefer to use Borax since it doesn't exhibit too much heat because of its very high resistance to electron flow between plates. There is no more need for a pwm to counter overheating in the system. It is quite slow in bubble production but it sound quite different from the bubbles produced in KOH electrolyte solution. Bubble a size of a pea explodes like a fulminate. It sounds like a .22 magnum fired and I have to stop testing because it does not only harm my ear but the tranquility of my neighbors. Sodium Borohydride has a valence of 10H2 making the compound much like a hydrocarbon. If liberated to form HHO with Oxygen it can give much better explosive power to the combustion engine than the HHO produced by KOH.
Some dude would think Borax as a catalyst. No. It is fuel in powder form with chemical formula of Na2B4O7*10H2O. It is Sodium Borohydride in natural occurring compound. If you look closely at the formula it has a valence of 10 atoms H multiplied by 2 = 20. Mixed with distilled water it displays maximum resistance of electron flow in between plates of dry or wet cells. In short it is simply of fuel of vast amount of Hydrogen atoms stored in a single compound. You cannot liberate this 20 atoms of H easily in electrolysis to produce a super Hydrogen gas. It has got to have a catalyst or an initiator in the electrolyte in order for it to be liberated into your car engine's intake. In my experience, the only chemical that can do it without altering the compound is Potassium Hydroxide. Control the amount of KOH to produce a maximum of 5 amps only and you will have a good production of HHO unlike those that you see being popped in you-tube. Oh by the way, please use an ear cover when you are about to test fire the bubbles that you produce in following this experiment. May God bless you and you can now run your car by 60%.
Hmm... it seems like you have done a bit of testing there Forest. Thanks for the valuable info!
Please give some more insight into the set-up required to get the most out of this.
How much Borax do you use, in proportion to the KOH?
You said that only KOH works, so that rules out my NaOH does it not -or can it still work with the Borax?
How do you feed it to your car -and with what results?
What is your best MPG reading?
Please let us know, since this can go a long way if things really are how you say they are.


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NICMOS was installed onboard the HST during the second Servicing Mission (SM2) in February 1997. Prior to the SM2 launch, an extensive ground testing program was executed, during which the NICMOS dewar was filled with about 240 pounds of liquid nitrogen. The nitrogen was then solidified by passing cold helium gas through a coil located at the aft end of the dewar. This reduced the temperature of the nitrogen to about 40 K. During testing and storage, passive heat inputs caused the block of solid nitrogen to slowly warm up - an expected behavior. To avoid reaching the triple point at about 63 K, the block was recooled approximately every 6-8 weeks, again using cold Helium gas circulating through the aft end cooling coil. During this process, nitrogen gas froze onto the cooling coil. This reduced the vapor pressure at the aft end, effectively pumping gas from the warmer fore end to the aft.
As the dewar was allowed to warm up, the ice at the aft end expanded, pushing into the interior surfaces of the dewar and deforming it. By mid-1996 the three cameras in NICMOS were no longer parfocal although there were good reasons to expect that they would return to a nearly parfocal state after a fraction of the nitrogen had evaporated on orbit. At that time a total deformation of about 4 mm had been observed and steps were taken to assure that the dewar remained flight worthy and that subsequent recooling Cycles did not stretch the dewar further. Also, the internal optical alignment and focus mechanism (the Pupil Alignment Mechanism PAM) was replaced with a version providing twice the focus range and a demonstrated capability for frequent movement. The PAM, originally intended to align the input beam onto the corrective optic and to bring NICMOS into parfocality with the WFPC2 (the only HST instrument without an internal focus mechanism), would be used to support a unique focus setting for each NICMOS camera and to switch between them routinely. After NICMOS was installed in HST, the dewar was planned to warm up to about 57 K. This high a temperature was never allowed to be reached during ground testing. The ice expansion caused by this temperature increase resulted in an additional dewar deformation, to the extent that one of the (cold) optical baffles made mechanical contact with the warmer vapor-cooled shield (VCS). The resulting heat flow caused the ice to warm up even more, to about 60 K, which in turn deformed the dewar more.
This unexpectedly large deformation had several undesirable effects, the most important of which are:
- The three cameras have significantly different foci, hence parallel observations are degraded. The difference between the NIC1 and NIC2 foci, however, is sufficiently small that an intermediate focus yields good quality images in both cameras.
- The NIC3 focus has moved outside of the range of the PAM. In order to enable execution of Cycle 7 programs that required the use of camera 3, two NIC3 campaigns were performed in January and June of 1998. These were periods of 2-3 weeks during which the HST secondary mirror was adjusted to bring the focus back into the NIC3 PAM range. During this time, HST performed exclusively NIC3 science, since no other HST instrument was in focus. While it was initially hoped that the NIC3 focus would eventually return to within the PAM range, we no longer expect this to happen. However, at the maximum PAM position, the degradation in terms of encircled energy at a 0.2" radius is only 10-15%. This is considered sufficiently small, and NIC3 will be offered as is in Cycle 11 and future Cycles.
- The thermal short increased the heat flux into the inner shell (and therefore the solid nitrogen) by a factor of 2.5 and thereby reduced the lifetime of NICMOS from 4.5 to ~ 2 years. The cryogen depleted in January 1999, and NICMOS has since been unavailable for science operation. To enable completion of the NICMOS science program despite the shortened lifetime, NASA and STScI adjusted the HST scheduling in such a way that NICMOS observations were assigned 40-50% of the total observing time in Cycle 7. Moreover, a second Call for Proposals (CP) for additional NICMOS science was issued in summer 1997. The proposals were put through the peer review process, and the full science program was executed before the cryogen depletion.
Following the recomemndations of the Independent Science Review committee, NASA has developed the concept of the NICMOS Cooling System (NCS) in order to restore and conserve an infrared capability on HST. The NCS is a mechanical cryocooler that will reenable NICMOS operation by cooling the instrument to temperatures around 75-86 K. This range is cool enough to allow operation of the NICMOS detectors, but is significantly higher than during Cycle 7 science operations. Therefore, many NICMOS parameters will be different from Cycle 7. In order to estimate the impact of the higher operating temperature on NICMOS sensitivity, a large monitoring program was executed during the instrument warmup following the cryogen exhaustion. The execution, data products, and results of the warmup analysis are described in detail in NICMOS ISR 99-001. A thorough discussion of a dark current anomaly observed during the warmup can also be found in this paper.
In March 2002, the NCS was successfully installed on the NICMOS, and the instrument is now performing even better than it did during Cycle 7. Now operating at a slightly warmer temperature, 77.1 K, the Instrument is more sensitive than it was during Cycle 7 and the temperature is also more constant. Furthermore, the focii for all three cameras have remained stable, and the NIC3 focus has moved in the positive direction relative to its Cycle 7 position, so as to be nearly in focus! Details about the operation of the NICMOS under NCS, as well as recommended strategies for observing proposals can be found in the Cycle 17 Instrument Handbook.


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Tiger Beetle and Larvae
"The common European species, Cincindela campestris, may be found flying and running around with great agility in the hottest sunshine. The larvae are of a singular form; they live in holes in the ground, maintaining themselves by a pair of hooks places on the enlarged eighth segment of their body, at such a height that their heads exactly occupy the mouth of the hole." — Goodrich, 1859
articulata, campestris, cicindela, Coleoptera, Insect, kbeetle, larva
S. G. Goodrich Animal Kingdom Illustrated Vol 2 (New York, NY: Derby & Jackson, 1859)


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Today's Hot Topics
- The President is tackling housing head-on. How's he doing?
- Pres. Obama has canceled a scheduled meeting with Putin. Smart move?
- What's the latest with the terror threat? We'll talk about it.
- USA Today White House Correspondent David Jackson
- Deputy White House Editor for Politico Rebecca Sinderbrand
- Now This News Reporter Julie Eckert
- Democratic Strategist Chris Kofinis
- Ploughshares Fund President Joe Cirincione
Don't Miss
- The Bill Press Show has a new TV home. We're joining Free Speech TV! Read about it here.
- Bill's Latest Column: There Was Never Any IRS Scandal After All
- Order Bill's latest book, THE OBAMA HATE MACHINE: The lies, distortions and personal attacks on the President – and who is behind them (this is the hardcover book. The paperback is available below.)
- Purchase a podcast subscription and listen to the show anytime you want, on your computer, iPod, or .mp3 player!
- Follow the show on Twitter. Bill tweets live from the White House press briefings.


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I just breathed a huge sigh of relief. Our dossier is done. Done. I think I've mentioned a hundred times how much I hate paperwork. I feel like for the past year and a half, it's been hovering over my head. It's done. Thursday we will scan and email all of it to our case worker, she will go over it with a fine tooth comb and note any changes that need to be made. Hopefully there will be none and we can send it to Ethiopia! I did converse with our agency shortly today and she said she is already on the lookout for a little boy for our family. EEEK! Although she cannot give us a time frame, she is optimistic that our wait shouldn't be long. Part of me is terrified, part of me wants to jump up and down like I just won a trip to Hawaii. Either way, it is out of our hands and all in Gods timing.
"Thank you, Lord, for working out all the details. Thank you for laying this on our hearts. Thank you for giving us encouragement every step of the way. Thank you for not letting the numbers and stress get in the way of our decision to follow your will for our lives. Thank you for that precious boy on the other side of the world that has no idea how much he is already loved. Prepare our hearts for him and his heart for us. Now hustle up and get him home!"


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JUNE 21, ESBER Recital Hall
Francis Poulenc, Music for Two Pianos, with Christopher Guzman, on Penns Woods Music Festival Chamber Concert.
JUNE 24, ESBER Recital Hall
Mozart Concerto for Two Pianos and Orchestra in E-Flat Major, K.316, with Christopher Guzman and the Penns Woods Festival Orchestra, Gerardo Edelstein conducting.
Cecilia Dunoyer is part of the Dosse-Dunoyer Two-Piano Duo. In Spring 2012, the duo performed in Versailles, France and the Music at Penn's Woods Festival. For more information on Marylène Dosse, please visit http://marylenedosse.com/index.php.
Cecilia also performs with David Stambler, saxophonist. For more information on David, please visit http://www.davidstambler.com/Home.html
Cecilia Dunoyer with violinist Juliette Greer


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In our May issue of Mpls.St.Paul Home, Scott Endres, co-owner of Tangletown Gardens, gave us a step-by-step tutorial on "30-minute gardens." He showed us how to create an easy landscape container garden (which was our mini version of a roof garden) and a vertical garden—inspired by Wise Acre Eatery (which if you haven't been, go for both the food and the earthy, chic decor!) where a "living wall" runs along the walls and above the doorways, creating a green, lush, dramatic backdrop. "We're plant people, for us it's second nature, but we understand not everyone would want an indoor irrigation drip system or something at that height," Endres says. True to his word, he scaled down the concept for an at-home DIY approach that works both indoors and out. Here's how:
1. Choose a location, indoors or outdoors, the back of a door or on a fence or wall, to hang a series of planters. Just like in the restaurant, Endres uses Wooley Pockets, which are soft, flexible, wall planters made from 100 percent recycled plastic water bottles and can be nailed into place.
2. Add plenty of potting soil that has a high water holding capacity and then start planting.
3. Use your eye to create a visual garden while planting. Endres mixes colors, textures, and various heights, using durable foliage, such as ferns, grasses, or spider plants.
4. Get creative. Or ask your nursery what would work best in your location. Endres loves throwback houseplants, such as Rex Begonia, Swinging Linda, and African Mask. However, he says to avoid herbs. If you want a vertical herb garden, be prepared to be constantly editing rather than admiring.
5. Water every other day outside or once a week inside. And voila, you've got an easy-to-create, easy-to-care for, on-trend vertical garden.


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Rent Julia Child's Provence House on Airbnb
Remember when Julia Child's Provence home "La Pitchoune" hit the market last year? It was scooped up pretty quickly, but you can still stay there (and master the art of French cooking, perhaps?).
The property was bought by Colorado-based couple Yvonne and Makenna Johnston, who are turning it into a culinary retreat. Programming doesn't start until 2017, but you can rent La Peetch on Airbnb starting in June.
- Rent Julia Child's House in Provence, Starting This June | CN Traveler


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Large Arrangement
Large Arrangement
This lush, airy, and sculptural arrangement in a glass vessel brings the wild outdoors inside. At 7"-10" in diameter, this design might serve as a small centerpiece or coffee table arrangement.
All arrangements are designed with the finest seasonal materials with a preference for local and specialty flowers and foliage. Each arrangement is unique and designer's choice. We welcome design requests, but cannot guarantee specific materials. Design notes and gift messages can be entered at checkout.


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Ultrasonic flow meter has now proven to be acutely prominent in companies that need the circulation of fluids or gasses to be quantified in an accurate way. They have a comprehensive assortment of software and also so are helpful in most businesses.
How they Work
Ultrasonic meters transmit ultrasonic flags through fluids and also certainly will find that the echoes once the signs are revealed away discontinuities this kind of atmosphere bubbles therefore forth interior these fluids.
This will aid in deciding the speed of flow of this fluid. They're employed as a portion of numerous household and modern software. They are sometimes used with water that is drinkable, waste oils, water, fluid gasses, and compounds.
Seaward oil phases use the tools to choose on the pace of stream of this petroleum which can be pumped out from the ocean depths.
There's not any compelling rationale to disturb or change the arrangement of these stations plus so they can be relied on to get the job done in a variety of ailments.
Truly, the mining, sewer, and sustenance commercial ventures are detecting these invaluable. Apart from this, find various ultrasonic machines at
http://www.aceultimate.com/item/1-Single-tankUltrasonicCleaningMachine (Also known as "หาเครื่องอัลตราโซนิกต่างๆที่http://www.aceultimate.com/item/1-Single-tankUltrasonicCleaningMachine" in the Thai language).
Benefits of Ultra Sound Flow Meters
Turbine flow meter has become cutting-edge could be operated from distant areas. They are able to be effortlessly produced and introduced when the necessity emerges. What's more, they have been eco-accommodating since they don't really enhance clamor pollution or surroundings contamination in virtually any way.
They are sometimes properly used to evaluate the stream of assorted kinds of gasses and fluids. They're employed to offer precise flow advice that's of such an excellent deal of relevance to different industrial businesses. They simply take a look at the principle about Ultra Sonic waves, their transmission and collecting through interlocking walls.


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The NY Citizens
This disc was kind of all over the place. It was not an anthology...not a greatest hits, per se...it basically ties up a lot of loose ends. Several tracks on here were released on their two full-lengths, some others came from singles and compilations, but a good chunk of this CD was made up of previously unreleased material. There is no escaping this one if you want a full NY Citizens collection. CD only, not too hard to find...yet...
|Approximate value ($)
|Moon Ska MR056 CD


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News > Press > Louisiana group honors contributions to green building movement
Louisiana group honors contributions to green building movement
23 Dec 2014
The U.S. Green Building Council Louisiana Chapter has recognized several local companies and individuals for their contribution to the green building movement. At the organization's annual meeting Nov. 20, Green Coast Enterprises and Roy O. Martin received awards, as well as the University of Louisiana at Lafayette School of Design and Erin Ryerson, the chairwoman of the Greenbuild Host Committee.
Ryerson, an associate at VergesRome Architects, received the Community Champion Award in recognition of her leadership of the group of local professionals who were in charge of soliciting local partners, developing tours, coordinating a legacy project, "greening" the city, engaging the community and recruiting volunteers for the Greenbuild International Conference and Expo, which took place Oct. 22-24.
Ryerson also coordinated approximately $150,000 worth of donations of green building products to Benjamin Franklin High School, making it the Green Schools Showcase during the Greenbuild conference. The products included sound-buffering ceiling tiles, self-tinting windows, Idea Paint to turn walls into white board, and various improvements to two bathrooms that make them water-conserving and energy-efficient.
The School of Architecture and Design at UL-Lafayette won the Champion Team Award in recognition of Geoff Gjertson's work with a team of students to design and build a modular house, the Beausoleil Home, that was transported to Washington, D.C., to compete in the Solar Decathalon.
The Innovation Champion Award went to the Roy O. Martin Martco Lumber Company. The company's management of its 582,000 acres of forest, where 12 million seedlings were planted in 2014, has been certified by the Forestry Stewardship Council. In addition to sustainably harvesting its forests, the company has worked to make its manufacturing plants energy-efficient and has donated $14 million to Louisiana service organizations.
The Operational Excellence Champion Award went to Green Coast Enterprises of New Orleans, in recognition of its work with New Orleans' schools, particularly in improving indoor air quality and education for occupants of green buildings.


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It all started with a "reluctant"| trip to TJ Maxx with my mom in Westwood. We were nearby and she just conned me with "just a quick peek". We were roaming around and suddenly an old friend from Woodcliff Middle School walk through the doors......Allison. She was another member of the Wodcliff Lake Bunch that didn't go over to Pascack Hills. Now I won't going into complete details but th e switch was great for both of us. Neither she nor I really ever fitted in with the "Woodcliff Lake School" crowd, she moved to Park Ridge after grade school in Woodcliff Lake. (More about this in Part II)
So Allison and I moved on to bigger and better things. Now I can lie and say we all of sudden reunited at TJ Maxx last night, when the truth is we've seen each other on and off for years. We always promised we'd get together and catch up, but never did. So last night SHE suggested we go out for a drink. Of course given my past experiences with that line (with other girls), I was automatically skeptical, but she gave me her # and after dinner I dialed the number. Of course I got voice mail and left a message. A few minutes later I found a message on my Facebook page saying the phone line was busy (thanks Mom)! Anyway we finally connected and it was decided we go to the Cornerstone (what else is new). So of course I was very excited.
The music in the Cornerstone seemed louder than usual so she suggested we "move on"=.......to Hoboken! Now here's a sign of someone who knows a lot about me. Allison said we'd go to one bar and that I wouldn't have to walk far. I cautiously reminded her I knew my own limitations and assured her I was up to the task. So we got into the car and headed towards the Parkway. To be continued with A Chance Encounter--Part II


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By Audrey Horton
The Court of Appeal has held that two drug formulation patents were invalid for obviousness.
To be a valid European patent, an invention must involve an inventive step (Article 52(1), European Patent Convention; section 1, Patents Act 1977) (EPC) (1977 Act). An invention involves an inventive step if, having regard to the state of the art, it is not obvious to a person skilled in the art (Article 56, EPC; section 3, 1977 Act).
Obviousness must be considered on the facts of each case and the court must consider the weight to be attached to any particular factor in the light of all the relevant circumstances. These may include the motive to find a solution to the problem the patent addresses, the number and extent of the possible avenues of research, the effort involved in pursuing them and the expectation of success. Generics (UK) Ltd v H Lundbeck A/S ([2007] EWHC 1040 (Pat)).
H brought an action for revocation of two of G's patents relating to the pharmaceutical formulations of the breast cancer drug Herceptin (trastuzumab). The disclosure of both patents was about making a lyophilised (freeze-dried) formulation with specific excipients.
The High Court held that both patents were invalid on the ground of lack of inventive step and added matter, and also refused proposed amendments to the patents. G appealed against the finding of obviousness and added matter.
The court dismissed the appeal. It held that both patents were invalid for obviousness. As a result the court did not need to consider added matter.
Whether it was "obvious to try" to find a solution to the problem was not a substitute test for obviousness, but merely one of many considerations to be taken into account. There also had to be a reasonable or fair prospect of success. There was no single standard of what amounted to a fair expectation of success, which depended on all the circumstances and varied from case to case.
The fact that the prior art disclosed that trastuzumab was in a phase II trial was sufficient motivation to cause a skilled team to embark on the project of formulating trastuzumab. The evidence showed a high degree of interest in trastuzumab by the time it was known that phase II clinical trials were underway, so the court's conclusion was justified.
It was not correct to say that the skilled person would only start on a lyophilised formulation if he found that a liquid formulation was not sufficiently stable. The patent explained that trastuzumab underwent degradation in solution, so it was at least plausible that there would be a degradation problem which could not be solved in the liquid form. As G had not displaced this natural inference by evidence to the contrary, the court could infer that trastuzumab could not be adequately stabilised in liquid form.
The court rejected G's argument that the High Court was not entitled to find that there was a fair or reasonable expectation of success. The High Court's judgment as a whole showed its assessment was that the skilled team had a fair expectation of success from the start.
An important issue was whether the correct question was whether the skilled person would, or whether they could, arrive at the claimed invention without inventive effort. A "would" test could be misleading as it was liable to bring in irrelevant considerations, such as whether it would be worthwhile commercialising an otherwise technically obvious product.
It was not always necessary for the court to conclude that the skilled person, acting only on the basis of the prior art and his common general knowledge, would arrive without invention at the precise combination claimed. As the screening methods were part of the common general knowledge, the tests involved were routine, the excipients were common general knowledge and there was no reason in principle why a successful lyophilised formulation could not be made, it was clear that the claimed combination here was one that could be made by the skilled team. The question was whether this was the type of case where it was necessary to go further and ask whether the skilled person would necessarily have made the precise combination claimed.
In an empirical field it would rarely be possible to predict in advance that any individual experiment would work. In many cases, the fact a routine screening exercise could be carried out would be inadequate to establish obviousness. Still, here, the team would have a reasonable degree of confidence that a series of experiments would produce some that would work. To impose a requirement that the skilled team had to be able to predict in advance which would be the successful combinations was unrealistic and would lead to the grant of patents which in fact involved no inventive effort. Here, the skilled person would expect a range of different results, some good and some bad, but there was no invention in embarking on a screening process to pick out the good from the bad. The fact that it could not be said in advance which the good ones would be did not always prevent a finding of obviousness.
This decision illustrates the difficulties faced by owners of pharmaceutical patents seeking to extend protection for an important product by patenting specific formulations or dosage regimes. A formulation which could be reached by a skilled team using well-known techniques and components may not meet the requirement of inventive step. The patentee must be able to put forward evidence that in the particular circumstances there was no fair or reasonable expectation of success, or showing that the result was unexpected. In this context, the decision provides a useful clarification of the "could" or "would" debate.
The decision also shows the difficulty of challenging a finding of obviousness on appeal. It emphasises the importance of the court's assessment of the specific facts of each case. The High Court's decision on obviousness was not open to independent evaluation by the appeal court unless there was an error of principle.
Case: Hospira UK Ltd v Genentech Inc [2016] EWCA Civ 780.
First published in the September 2016 issue of PLC Magazine and reproduced with the kind permission of the publishers. Subscription enquiries 020 7202 1200.
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Our Pink Damask frosty plastic shopping bags are ideal for retail purchases, special occasions and gifts. The soft pink damask style adds a hint of sophistication and style at an affordable price. These 8" x 5" x 10" bags feature strong handles and a hard board bottom to provide rigidity. They are an obvious choice for bridal, children's retail, and holiday sales promotions. These bags are sold in cases of 25.


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- Kitchen & Home
Go from bed-head to boardroom with a Nespresso coffee
TS Eliot once wrote 'I've measured out my life in coffee spoons' and when you consider how much we get through, most of us probably could.
More than 70 million cups of coffee are drank in Britain every day with our appreciation of the bean ranging from the decadence of a steaming shop-bought latte to the freeze-dried stuff sheepishly lurking in our kitchen cupboard.
For many the difference between freeze-dried and fresh-ground is wider than the chasm separating a Ferrari and Del Boy's three-wheeled van, but thankfully Nespresso coffee machines are here to fill the gap.
Coffee is the first thing many of us think about as we emerge from our beds sporting the kind of messy hair and streaked make-up seen backstage at a Kiss after-show party. To those in the club, the elixir is what kryptonite is to Superman - transforming them from bed-heads to high-fliers in less time than it takes for Clark Kent to disappear into a phone box and emerge in seriously lurid spandex.
Starting the day with freshly ground coffee used to mean spending loads of money on chrome-plated Italian kit better looking than a supermodel or dashing down to the local Starbucks in your flannel pyjamas. Thankfully, times have changed and machines such as the Nespresso CitiZ mean we can create coffee in our kitchens that'd see even the best baristas offering begrudging applause.
Research from Nespresso reveals coffee is the drink of ambition, with more than 70% of senior managers guzzling it down before important boardroom meetings.
They don't come much more ambitious than the latest crop of Apprentice candidates. Although they may be all braces, briefcases and bluster in the boardroom their day begins in chaos with a surprise call from Lord Sugar and lots of hopping about in odd socks and awful boxers.
The point is we all start the day in the same way - utter chaos.
Whether you spend your days flying high or tending to a toddler's cry, mornings are bedlam. The trip from the bedroom to the bathroom to the kitchen is full of banana skins as we wander about absent-mindedly. Pouring milk on our toast, putting our jumper on the wrong way round and slotting the cereal box back in the fridge - we've all been there.
But the Nespresso is designed to make sure when it comes to your coffee the only thing steaming is your mug.
Recognising the need for calm and order, the CitiZ brings a little Zen back to your kitchen with capsules containing the perfect amount of coffee. While we're talking about perfect, the machine can be programmed to create a cup tailored to suit your taste. No more crying over spilt milk, or snivelling about sugar sprinkled on your worktop.
With no filters to fiddle with or percolators to position you can enjoy a moment of relative calm - even if your kitchen is busier than London St Pancras as you go about feeding the toddler, getting the kids out of the door or preparing for a big-bucks breakfast meeting.
Getting everyone out of the house on time takes more planning than the Olympics but the last thing you want is to remember you've left something switched on while you're on the school run or munching your way through a power pastry in a swanky meeting room.
At least with the CitiZ that stress won't be coffee related: The
machine switches itself off after half an hour.
Whether you're a high-flier or a busy mum the Nespresso can help get your day off on the right foot - even if you got out of the wrong side of bed.
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Much needed was a coastal place my mates and I could afford that didn't bargain on style – youthful, different, and perfect for chilling.
White structures, grey aluminium fixtures, contemporary furniture, and modular design were conjuring in my mind. Individual units with little courtyards scattered between the coconut trees, maybe?
All this and pool beds that partially float, became reality.
Cement floors that cool your feet and serene white interiors engulf you in tranquil relief from coastal sun. Less is more in twelve separate single rooms each with en suite bathroom. Paintings handpicked from the street art market to ensure the ambience is perfect.
Nothing makes you hungrier than chilling by the pool. We'll keep the hunger pangs at bay with our snack menu brimming with tongue trippers. Hot butter specialties, devilled chicken, cheese toasties or club sandwiches from the poolside open pavilion café. Wash them down with the freshest juices.
Signature Sri Lankan street food will guide you to the café a few steps away. Beach-style wholesome food, koththu, rotty, sweet and savoury hoppers or fresh and simple seafood impatiently wait to conquer your appetite.
Balmy coconut trees throw their shadows on you as you pad your way on sandy tracks from room to pool. Lay back and get bronzed on the pool beds to make friends back home green with envy.
The old trains chugging on the rail track behind add a smattering of undeniable romantic charm.
A notch simpler, but it is Ceilao.
Kabalana is best known for surfing and being on the west coast it's fast to reach. Ideally located with Galle and Unavatuna to the North and Mirissa to the South. The historic sites of Galle, the touristy beach buzz of Unavatuna and the whales and dolphins of Mirissa, each one of them so different and from where we are, just a short drive away.
The rates for a beautifully appointed room at Kablana Hotel by Ceilão Villas are:
|Room Type
|No. of Rooms
|Rate per Night
|(6 available)
|Starting from USD 80
|Room Rate includes complimentary breakfast
|(6 available)
|Starting from USD 80
|Room Rate includes complimentary breakfast
Book Now
Inclusive of Service Charge and applicable government taxes


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Aviation History
952 FLIGHT International, 9 June 1966 The first of 12 DC-9-lQs for Continental Airlines flying on test from Long Beach, California AIR TRANSPORT... CALEDONIAN'S 707-339C PROSPECTS... PLANS and prospects for the introduction next spring of the Boeing 707-339C ordered by Caledonian Airways last December Flight for December 9, 1965) are the theme of the June issue of the airline's paper Caledonian International. Mr Adam Thomson, the carrier's chairman, writes: "Caledonian Airways are poised on the brink of the exciting course of controlled expansion which we have been planning for many months. No airline can stand still and survive and we have decided on a series of measures which will place the company among the foremost of the world's independent operators." As already recorded, Caledonian will use the convertible 707 on world- wide charter services with transatlantic routes doubtless being the most frequently traversed. In Caledonian International, Mr Thomson spells out why he chose the 707 in preference to the Super VC10: "We require a fully convertible passenger/freight aircraft . . . which can operate with a full load of passengers between Britain and the American West Coast . . . and operate economically on our great variety of routes." An important, but apparently not a crucial, aspect of 707-339C economics that may not be resolved for some months yet is whether or not Caledonian will pay the full import duty—though (see page 950) a decision in principle has been made that this duty must be paid. Mr Thomson writes: "I feel sure that with the right type of scheduled service between the east coast of North America and Britain, the additional operating cost of the Super VC10 against the 707 could be balanced by a higher load factor attracted by the passenger appeal of the Super VC10. However, our charter type of operation does not depend on load factors, as in each individual charter case the total capacity of the aircraft is sold. Therefore the governing factor is the basic seat cost of operating the full aircraft. ... We have stressed the fact that the foreign currency we spend on the purchase price will be more than balanced by the dollars we shall earn with the equipment . . . Our jet will be able to provide fastest Prestwick- New York service, or to carry a full payload of 165 passengers from Prestwick - San Francisco or comparably in an eastward direction, from London to Colombo, Ceylon ... the aircraft is costing us $7.5 million (£2.58 million)." ...AND PERFORMANCE IN the same issue of Caledonian International referred to above, Capt Stuart Calder, director of operations, and Mr Dennis Walters, technical director of Caledonian Airways, said, after recent flights in a Boeing 707-32OC at Seattle, that they were delighted with the aircraft. Captain Calder spoke enthusi- astically about the take-off capabilities of the 320C. "It was decided I should pilot the aircraft on take-off and that two of the engines should be cut. Shortly after leaving the runway one engine was cut followed by a second but I found that the aircraft was climbing without any bother at 600ft/min. "There is no doubt in my mind that this is probably the finest aircraft yet produced from the point of view of the captain. I also carried out one landing and found it was easy to handle." While Capt Calder was at the controls the aircraft was stalled at 15,000ft but again he found no difficulty in maintaining control. Mr Walters was also on this flight. He said: "I found that the aircraft performed under near normal conditions on only two engines. It is a marvellous aircraft, a wonderful piece of engineering." EASTERN'S BROAD VIEW OF SSTs THE recent purchase by Eastern Airlines of options on two Concordes in order to strengthen the airline's case for Pacific service licences (see Flight for June 2, page 917) is seen by Mr Floyd D. Hall, president of Eastern, as a complementary move to the earlier ordering of the bigger American SST. Two places in the queue for United States SSTs were bought by Eastern earlier this year. Mr Hall understands that the Con- corde will be in commercial service in late 1971, with the American aircraft becoming available in 1974. Mr Hall said: "These two types are complementary equipment serving different needs. The greater speed and capacity of the American SST will be an advantage on the longer haul, higher density routes. The Concorde will perform best on routes not quite so long and with somewhat smaller traffic volume. "Eastern plans to apply the supersqnics to existing routes and, if successful in cases now pending before the CAB, to serve across the Pacific and along the 'Space Age Corridor* through the St Louis gateway to Seattle." Mr Hall said that Eastern has become a supersonic aircraft buyer for two major purposes. "We want to build our capacity to serve the cities on our existing 19,000-mile route system. But we also want to develop our ability to serve the new routes for which we are now seeking authority. We are putting cash on the line for supersonic and other aircraft to prove and provide our capability for 'Space Age Corridor' operations into Denver, Salt Lake City, Portland, Seattle, and in the trans- pacific case for Great Circle routes from Seattle and Mexico City to the shores of the western Pacific. In the latter proceed- ing, we are also proposing non-stop flights to Hawaii from St Louis and other mainland cities." In planning for supersonic aircraft use on the present system. Eastern engineers are conferring with Boeing, Lockheed and BAC-Sud personnel to consider the possibility of modifying designs to provide greater capacity for passengers and car j° in exchange for somewhat less range. The Concorde wouw permit Eastern to fly its proposed 4,164-mile St Louis-Hawaii service in less than four hours. Boston to Houston, 1,655 mile apart, would take lhr 52min; the 1,469 miles from New *o»
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Jack, Nathan and Kris do a full spoilery review of the just released Doctor Strange movie! The lads discuss all things magic and try to work out just how time loops work in a dimension without time. How good is Benedict Cumberbatch in this role and what is the deal with Rachel McAdams sexy mole.. also; Rotten Tomatoes said it was 96% at the time of this recording, which is pretty good.
- What was Thor doing during Civil War
- Are you allowed to wear headphones while driving?
- Doctor Strangelove is a movie
- The country of Moombabwe
- Nathan takes a shit on Eric Bana's accent in Black Hawk Down
Download the Mp3 file using this ere link or subscribe to the show on the iTunes


text: The Ultimate Balance of Beauty and Strength ZenFone 2 is pure power encased in sheer beauty. The iconic ASUS concentric-circle design adorns both the fascia and rear key, a beautiful, tactile effect that's achieved through precision machining — producing a mere 0.13mm pitch that looks as premium as it feels. Premium Colors for Your Style Vibe ZenFone 2 is available in five striking colors to reflect your personality and mood. Choose from Pure Black, Glamour Red and Ceramic White — and delight in choosing an ASUS ZenUI theme to match. Beautifully Crafted to The Ultra-Thin Edge ZenFone 2 has an incredibly-slim profile — it is just 3.9mm at the thinnest edge. This is more than an impressive engineering feat: the thin design is so comfortable to hold, and makes using ZenFone 2 easier. With less body between you and the display, ZenFone 2's one-handed grasp puts everything within reach. THIN EDGE Ergonomic Arc Design with Intuitive Controls on the Back There is no technology better than yourself. ZenFone 2 defines a more instinctive way for human interaction, encompassing a physical rear key as part of the Ergonomic Arc design. Snapping selfies, adjusting the volume and retracing your steps now feel as natural as your grip. Less Is More Amazingly thin bezel for a true big-screen experience ZenFone 2 is the 5.5-inch smartphone that fits in the body of a traditional 5-inch device. This supreme engineering achievement was made possible by reducing the bezel width to a sliver, creating a remarkable 72% screen-to-body ratio. Crystal-Clear, Razor-Sharp Display IPS beauty for an unparalleled viewing experience ZenFone 2 is equipped with a high-resolution 1280 x 720 HD IPS display that offers wide 178-degree viewing angles. The staggering 267ppi pixel density renders every image in eye-delighting detail; and with ASUS TruVivid technology built in, ZenFone 2 brings color to life in brilliant clarity.


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Essays are a big part of schoolwork. They can be found in newspapers, books, and magazines. There are several types of essays but when you write to give information and facts about a specific topic, its writing an informational essay. This book will give you all the tips on staying organized, how to perform your research, and explain the topic or process clearly for your readers. Tips on sequencing, cause and effect, and comparing and contrasting are given to ensure your next informational essay is a winner! This book will allow students to refer to details and examples in a text when explaining what the text says explicitly and when drawing inferences from the text.
Have you ever been assigned a science project at school? It can be a little overwhelming. But, if you follow a few simple guidelines, it will make it an enjoyable experience. Think about something you wonder about. That is a good start. After picking your topic, conduct research by using the Internet or library, talk to experts about the topic youve chosen, form a hypothesis, test it and write down your observations, and form a conclusion based on them. Record all your information and present your prize-winning project to your class! This book will allow students to explain events, procedures, ideas, or concepts in a historical, scientific, or technical text, including what happened and why, based on specific information in the text.
Studying for a test can be a daunting task. Some people wait until the last minute while others are organized and prepared when the time comes. Good study habits are all about paying attention in class, taking good notes, finding a quiet place where you can concentrate, and planning ahead! Learn how to reduce anxiety before a test by following a few simple rules that will help you to ace your next big test. This book will allow students to determine the main idea of a text and explain how it is supported by key details; summarize the text.
Want to be more successful in school? This book will help you achieve this by using two important strategies that can help you understand what you are learning: note taking and close reading. With simple steps on how to stay organized for that upcoming quiz or project, readers will be able to tackle new ideas or challenging topics. This book is filled with great ideas on how to use these two strategies to ensure you ace your next test! This book will allow students to determine the main idea of a text and explain how it is supported by key details; summarize the text.
There are certain steps you can take when writing a research paper that will make the finished product a lot easier! Many people, such as scientists and businesspeople use research skills to make products better or more useful, and to teach others how to do their jobs more efficiently and effectively. Picking a topic, gathering and organizing your information, and putting it all together are discussed in this title. By following these steps, you are guaranteed to get an A on your next research paper! This book allows students to determine the main idea of a text and explain how it is supported by key details; summarize the text.
Writing an opinion paper isnt writing about factual information, but writing about what your opinion on a topic is. The challenge is to appeal to other peoples feelings and emotions, while leaving yours out. This type of paper can be more challenging than you think. Organizing your thoughts, writing a list of reasons that support your opinion, and which reasons can be proven with facts and which are simply how you feel. Learn how to frame your paragraphs, formatting, and transition words that help you make your opinion clear and persuasive! This book will allow students to ask and answer questions to demonstrate understanding of a text, referring explicitly to the text as the basis for the answers.
Wikis can bring people from around the world together to collaborate on online projects. Wikis also offer a great opportunity to practice using technology to produce and publishing writing. Readers of this book will learn how to create, edit, and manage a wiki. They will find out how to use photos, text, sounds, and videos to convey ideas and share information with their group. They will also learn the importance of sharing the workload with team members.


text: Men's grey training T-shirt from British menswear brand, Lyle & Scott. Crafted from moisture wicking fabric, the 'Jones' tee will keep you cool and comfortable during workout sessions. The T-shirt is designed with ergonomic seams that move with your body during exercise. Complete with a signature golden eagle logo on the left chest, contrast blue stitching and a ribbed crew neck. 95% Polyester, 5% Elastane Model is 188cm/6'2 and wears a size M.


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Changeabill by Fred Berthelot
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Fred Berthelot is an outstanding magician from New York City. This DVD is Fred's first exposure to many magicians but you'll be delighted with his methods. They are diabolical, practical and easy to do.
Changeabill is a killer. It's skill based, so no gaffs are necessary. Once you learn the method you're always ready. All you need are two bills!
Changeabill is a complete routine by itself but Fred's creation lends itself as an add-on to many magic applications. It's the perfect switch for your favorite Bill To Lemon routine. If you perform any of the multiple bill changes such as 3-D Cash or the Hundy 500, Changeabill is the perfect "out" for when an audience member wants you to change their one dollar bill into a one hundred dollar bill.
But wait...there's more. Fred goes into incredible detail during the step by step instructions. You'll soon see why Changeabill is so practical. You can do it standing up, or you can do it seated.
Also included is a special "One Million Dollar Bill." These usually retail for as much as $8.95 but it's yours for free! We teach you all the work on what I believe is the best advertising give-a-way you can use with your magic. We also show you the best source to have yours printed. Check out the photo at the bottom of the page. You'll see Fred with his picture on the Million Dollar Bill. You can also put your phone number, email address, web site address or any other information you'd like. Using Changeabill to magically change a one dollar bill into a Million is extremely memorable, the spectator always keeps the bill and when he needs magic at a corporate function or party he already has your contact information!
Included are many ways to effectively use Changeabill including several ditching techniques, using borrowed bills, and even as an invisible billet switch for mentalism
As a bonus Fred has also included his signature card effect "Houdini". Just like Changeabill, this routine is extremely visual and it's a fooler that's easy to do. No gaffs are required for this totally practical workers routine.
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How fun are these!
Make Life selvages
selvages are
spectacular as well.
Look at those!
hunky dory is here! a lot of it.
hunky dory is here! a lot of it.
I love everything about that Make Life...ReplyDelete
And yes - I'm extremely happy the third time was the winner! :) Sent my contact info by email. HURRAY FOR QUILT TAFFY!!!ReplyDelete
Hunky Dory AND Des?? Too much fun to be had. What will you girls be up to?? LOVE the selvedges on Make Life! Finally a U.S. fabric with cute selvedges.ReplyDelete
How fun you both are! Love reading your posts and the eye candy is wonderful!ReplyDelete
Hi Corrie, Thanks for stopping by my blog. Adorable fabrics you've shared and so tempting. I love polka dots.ReplyDelete


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Happy Mother's Day UK Mums!
I was treated to a lie in this morning - I didn't wake up until 7am (according to my Mum that's the middle of the night!), then I was treated to a coffee along with a scrummy hot breakfast and oodles of kisses and cuddles from my boys. They'd both made me beautiful cards and I think the Spark had a lot to do with my gift too.
I've been given a pass out card to craft but with the promise not to work and then my Mum in Law is coming round for dinner later. Perfect day.
So I'm catching up with some Project Life layouts and boy am I having fun, proper in the zone I am. So what can I show you today? Well me sewing business is doing very well and of course I need to send out thank you cards with orders so I figured I'd start making them in batches. I got 10 done really quickly too.
I think these are Stampin' Up! note cards and envelopes, great for printing on. I used the same digi papers I'd used on my Mother's Day cards, this time I printed the patterned paper onto the front of the cards and then over printed the sewing machine images (all from Pink Petticoat).
Then I added a little detail using markers and a flower button on the sewing machine handle.
With blue daisies:
And with pink:
Now I'm back to my Project Life layouts. I'm off to the Hobbycraft show at the NEC later this week with my friend Kay, can't wait I haven't been in over six years!!!
xxxPin It


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Undergraduate degrees
Our interdisciplinary Bachelor of Environmental Design program approaches the production of space from the unique perspectives of architecture, landscape architecture, and urban design. You will be immersed in a comprehensive curriculum centred on design thinking and critical investigations of the social, cultural, and environmental issues of producing space.
The direct-entry Bachelor of Design in Architecture, Landscape Architecture and Urbanism is the successor to the Bachelor of Environmental Design program. Final approval by the Ministry of Advanced Education is currently pending.


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Academics and Researchers,
Sosyoekonomi is international, scientific, peer reviewed and quarterly journal. It has been published by Sosyoekonomi
Sosyoekonomi is not only designed for studies and researches on economics, also on public finance, politics, public
administration, labour economics, law, sociology and also has been published as hardcopies and via internet.
Sosyoekonomi is covered by several citation and abstracting/ranking/indexing databases.
Before the papers are submitted, please read the Notes for Contributors. Submitted papers will be published at least
after they have been approved by two reviewers. Please note that all submitted papers will be checked by iThenticate
before refereeing process.
I would like to thank you for your interest to our journal in advance and waiting for your opinions and recommendations to
convey to our e-mail address.
Ahmet Burcin YERELI


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CPAN Ratings: DateStamp reviews http://cpanratings.perl.org/dist/DateStamp CPAN Ratings: DateStamp reviews en-us 2000-08-23T07:00+00:00 firstname.lastname@example.com firstname.lastname@example.com Perl 1901-01-01T00:00+00:00 1 daily Mark Stosberg http://cpanratings.perl.org/dist/DateStamp#2141
Rating: 2 stars

In isolation, this module looks OK. The interface is decent, although including "return_" in the method names adds little. The docs and automated tests look good enough.

But this module does not exist in insolation. There are many date/time modules to come before it, including the excellent DateTime suite.
 Considering DateTime handles this task and more and is well tested through wide-use, it's hard for me to recommend this one.

The idea of focusing just on returning the current date is interesting, but really what most of this module does is try to make formatting a date easy, and the current date is just a special case of that.

I would rather see the effort applied to this module go into a DateTime formatting module, although I'm not convinced another one is needed.

 Mark Stosberg 2006-04-06T13:41:19


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Happy Wednesday!
The sun has come out again, after days and days of flooding gray clouds, constant dripping, and dank, bleary chill.
Perfect crochet weather. 🙂
A sweet friend requested today's featured project. She spotted it online and simply had to have one for her mother.
I finished just in time, as Mother's Day is right around the corner!
The best part? Her mother's name is Star. ❤
The pattern is a dream. Simple enough to remember after the first few rounds, but such a clever desgn: both the peak and the valley stitch are the designer's personal creation. I love it, and will definitely be making more.
Just starting out:
Growing larger:
Too big to shoot:
Almost finished:
Pretty rainbow colors:
It was a delight to make and my friend loved it.
I loved discovering a great new pattern.
Happy hooking!