text:
Nazism, Fascism and the Theosophical
Movement During the Twentieth Century
Carlos Cardoso Aveline
The aftermath of a Nazi bombing raid, in London
"To form the nucleus of a Universal
Brotherhood of Humanity, without
distinction of race, creed, sex, caste or color."
[The first and main object of the theosophical
movement, founded in 1875 in New York City]
In a world still partly dominated by bigotry and by ritualistic religions, it is only natural that the theosophical movement – being rather a non-violent extinguisher of illusions – should be attacked in various ways, from within and from without.
As an instance of such attacks we have a variety of baseless texts which accuse the theosophical movement of having had sympathies for Nazism or Fascism. There are various sources of disinformation around the subject of Theosophy and Hitlerism, and it seems proper to bring some evidence about the actual relationship between the two, including the period during the Second World War.
Nazism misused Hindu sacred symbols with selfish goals. Nazi leaders practiced some kind of anti-humanistic sorcery, and they had much in common with the disguised "mysticism of hatred and violence" which was carefully developed by the Jesuits and used by the Vatican since the 16th century. Of course, the Vatican has always been against Theosophy, for Theosophy proposes universal brotherhood and denounces and fights every form of religious dogmatism.
As facts often speak by themselves, we will start by examining the actual situation, country by country, during the second world war.
* In May 1940, the Netherlands Section of the Adyar Theosophical Society was closed right after the German invasion. Theosophical activities went on privately and clandestinely, although they were forbidden by the Nazi invaders. [1]
* In Belgium, on the 10th of May, 1940, an intense bombardment of Brussels took place. After that came the Nazi pillage of all Lodge and private libraries. Josephine Ransom writes that the General Secretary, Miss Serge Brisy, with the concierge, made a huge fire, while the air raids went on, and burnt all papers that might compromise the members. Miss Serge Brisy then took refuge in Bordeaux for some months. During her absence, the Gestapo searched her house and took away her books and lectures, as also the books in the Section headquarters and in the houses of several prominent members in Brussels and of Lodge Presidents in the Provinces. In December she returned to find the Section closed. The Gestapo in vain threatened punishment if the list of members was not produced. Names were not revealed. [2]
* In France, a few days after the German army entered Paris, military officers closed the headquarters. Later they carried away records, library books, and other objects belonging to the Adyar Society. A few months after that the Vichy [Nazi-controlled] government dissolved the Society and twice all Civil Servants had to declare they were not members of it. The Gestapo took the headquarters building in Paris and made it their centre for their Secret Service. [3] This is interesting because the Gestapo used jesuitic and sorcery-oriented procedures, as we will see later on in the present article. They might be interested in taking advantage of any "subtle magnetism" created by theosophical studies.
In spite of the Nazi occupation, some meetings of Adyar Society members went on in France, clandestinely. The movement went back to life as soon as the Allies liberated the country.
* The Greek Section of the Adyar Society made a pronouncement to all theosophists worldwide denouncing invasion of Greece by Benito Mussolini's, Fascist Italy. [4] We must remember that the Vatican – located in Rome – officially supported the Fascism in Italy.
* The Italian Section of the Theosophical Society had been dissolved in 1939 by the Fascist Government. Some informal activity was kept and the work came back to public life in 1946. [5]
* After Poland's invasion, members of the Adyar Society in Hungary helped masses of Polish refugees arriving in that country, some of whom were Theosophists. [6]
* In Germany, the theosophical movement was dissolved and forbidden from 1939 through 1945. Only a few private meetings took place clandestinely. [7]
* In Norway, all theosophical activities were forbidden since the invasion of the country by the Nazis in April 1940, and up to its final Liberation in 1945. [8]
* In England, Josephine Ransom reports that the Adyar Society work was much hampered, though lectures and classes continued despite heavy air-raids and some bombs falling so near to headquarters that windows were shattered and ceilings fell. [9]
* In the New Year of 1942, George Arundale, an English citizen and then the international president of the Adyar Society, once more urged India to participate whole-heartedly in the war against the Nazis.[10]
* As to C. Jinarajadasa, who in those days played a leading worldwide role with regard to the inner or esoteric activities of the Adyar Society, L. H. Leslie-Smith wrote:
"Brother Raja spent the greater part of the period of the second war in London, which had become the headquarters for many European governments whose lands had been overrun and also for the Theosophical Society in Europe. He lived at 33 Ovington Square to make it a spiritual centre and focus of theosophical inspiration during the dark years. From there, by means of a vast correspondence, he gave comfort and encouragement to members in all countries where there was still a postal service. He often worked through the night till four o'clock, and a pile of letters would be left on the floor for his secretary later to stamp and dispatch to various parts of the world." And L. H. Leslie-Smith adds: "He played a courageous citizen's part as a volunteer in the Air-Raid Precautions service [Special Fire Guard]. His attitude to danger was exemplified one afternoon when the present writer was sitting with him in his first-floor room at 33 [Ovington Square]. The sirens sounded to give warning of enemy bombers approaching. He registered the warning, and we went on talking. A few minutes later there was the crescendo whine of a bomb coming down – still no reaction; then the crash of the explosion not far distant. The conversation continued without the flicker of an eyelid to its natural conclusion."[11]
The United Lodge of Theosophists
* The Pasadena Theosophical Society and the United Lodge of Theosophists (U.L.T.) were both founded in the United States – as the theosophical movement itself – and are, even now, most active in this country. During World War II, "Theosophy" magazine, published in Los Angeles by U.L.T. associates, criticized a few times, mostly in small notes, aspects and events of the war. It showed how unfortunate wars in general are. This was made from the philosophical perspective of the sacred wisdom and ancient tradition, and on the basis of the principles of non-violence (ahimsa) and universal brotherhood. [12]
* From 1931 and up to 2011, every year around June 25 the central office of the United Lodge of Theosophists in Los Angeles used to send a letter to its Associates and friends all over the world. The yearly U.L.T. Letter dated June 25, 1941, opened with these words:
"This year, as our annual greeting goes to members of the United Lodge of Theosophists everywhere, it is with no certainty that the message will reach its destination by other than 'astral' mail. Last year, London Associates read the U.L.T. Letter in a cellar while bombs burst overhead; this year, their building is gone, save for two rooms and the books, while meetings still continue, the London Bulletin has been published regularly, and lecture work has been extended to Bath and Salisbury." [13]
* In the following year, 1942, the U.L.T. Letter expressed a feeling of admiration for its London Associates:
"Theosophists there set courageous example in the moral striving that the world at large needs so much to learn. Without hate, without despair, without condemnation of any human soul, the London work goes under terrific stress and growing privation. This is an immortal spirit worthy of a brave people….."
The text goes on then to comment on the Nazi occupied Norway:
"Elsewhere, in lands suffering the heavy hand of occupation, the moral life of the people grows strong. From Norway, where regular meetings are no longer possible, came this stirring word last summer; '…. it seems that present trials make people more open-minded and eager to listen and to realize; so the possibility of more and more people turning to the study of philosophy is greater and the prospect brighter'." [14]
* In 1943 and 1944, the U.L.T. Letters accompanied the sustained effort to keep the theosophical movement active in spite of war. In 1945, it greeted the end of war and the progress of the U.L.T. in London. In 1946, it announced that, after the Nazi defeat, regular meeting of the U.L.T. were once more in session in the Paris Lodge as in other parts of Europe.
A Letter From Jean Overton Fuller
British theosophist Ms. Jean Overton Fuller lived and wrote near London. She was one of the main biographers of H.P.B. Author of "Blavatsky and Her Teachers" [15] , among her various books there are other interesting biographies, including works on the Comte of St. Germain and on Francis Bacon. She lived a long life of service and died in 2009, at 94. Jean not only studied History. She lived it, too. In 2006, I had already started to investigate the true relationship between Nazism and Theosophy, and asked her to write down a few commentaries on the Second World War. Jean wrote, in a letter dated 27 May 2006:
"Dear Carlos,"
"I was pleased to hear from you again but shocked to learn from you that there has appeared a book, UNHOLY ALLIANCE [16], which accuses the Theosophical Society of having inspired Hitler. This is of course nonsense."
"I lived in London throughout the war, through the Blitz and through the V missiles. I worked from 9-5 daily for a Government Department, the Postal Censorship Department of the Ministry of Information, and at night, three nights a week, I worked, first in caring for people whose houses had been destroyed by bombing, then as a trained fire-fighter belonging to a group that liaised with the regular Fire Brigade. If the alarm went and it was my night on duty I had to get out of my bed and go and stand on a cold doorstep, with others, with pick-axe, bucket and a hose … I was also a member of the Theosophical Society. My membership dates from 1942, and never did I hear within it any expression of liking for the Nazis!"
"But wondering what could have given this writer this strange, erroneous idea, it came to me that the tracing of the origin of the races – particularly as it is set out in A. E. Powell's book THE SOLAR SYSTEM, based on texts here and there by Annie Besant and C.W. Leadbeater, from their researches, could give to someone's becoming over-interested in race. I am sure neither Mrs. Besant or Leadbeater ever thought to encourage racial discrimination. Discrimination against any race or religion would be in direct contradiction to the Society's First Object. But I imagine to what use a mind like Hitler's could put those texts. I am glad to have your useful information about what happened to the T.S. in the various countries occupied by the Germans."
The Arcane School and World Good Will
* Originated in the Theosophical Movement and founded by Alice Bailey, the Arcane School, the "World Good Will" and its "New Group of World Servers" got totally engaged in actively supporting the Allies during the Second World War. Bailey even criticized the pacifism of Mahatma Gandhi – who as an activist was very much inclined against the British and found it perhaps politically profitable not to support them against the Germans, but was criticized for it.
In August 1942, Alice Bailey wrote about "…The pacifist attitudes – idealistic and impractical and finding their focus today in the attitude of Gandhi. He brings into clear perspective the uncompromising, fanatical attitude which is non-realistic and which will willingly sacrifice lives, nations and the future of humanity in order to attain its object." Throughout her writings in the years of War, Bailey described the Allied and democratic nations as inspired by the Masters, and Hitler's Axis as inspired by hatred and evil motives. [17] Ms. Bailey was right in this respect and in general lines. For theosophy needs liberty of thought and respect for human rights.
Jiddu Krishnamurti
* Jiddu Krishnamurti, who left the Adyar Theosophical Society in 1929, had a radical pacifist position. On describing the 1942 events, his personal friend and biographer Mary Lutyens admits:
"For those in England who had been proud to stand alone against Nazi aggression, who had felt exalted by the Battle of Britain, who had thrilled to Churchill's words and somehow managed to contain their terror during the blitz, believing passionately that they were fighting the embodiment of evil, Krishnamurti's pacific outpourings from such paradises as Ojai [in California], Martha's Vineyard and the Sequoia National Park were hard to take. Lady Emily evidently told him as much with some asperity and accused him of escaping from horror…". [18]
This was not the only mistake made by Krishnamurti, who – since 1929 – was not a member of the theosophical movement. Yet, whatever one's opinion about Mr. Krishnamurti's pacifist attitude, he clearly cannot be accused of having sympathies for Nazism or Fascism.
The Theosophical Ideal in the United Nations' Charter
* After Adolf Hitler's defeat, the United Nations Organization emerged in 1945 as a global network of countries. This occurred exactly 70 years after the Theosophical Movement was founded, in 7 September 1875. The period of seven decades is numerologically significant. Probably it is also not a coincidence that the U.N. is established in New York, the very same city where the theosophical movement – its own occult archetype – was founded.
* The first and main object of the theosophical movement, which refers to the ideal of Universal Brotherhood, was clearly adopted by the United Nations. The first Article of the U.N. Charter, which states the four Purposes and Principles of the U.N., is profoundly theosophical. The United Nations goals are:
"1) To maintain peace and security (…); 2) To develop friendly relations among nations (…); 3) To achieve international cooperation in solving international problems of an economic, social, cultural, or humanitarian character, and in promoting and encouraging respect for human rights and for fundamental freedoms for all without distinction as to race, sex, language, or religion; and 4) To be a center for harmonizing the actions of nations in the attainment of these common ends." [19]
* Since 1945, the victory of the Allies has been officially celebrated every 8th of May. And it is the very same day when H.P. Blavatsky died in 1891, and when theosophists have celebrated her life since her departure. Another interesting numerological "co-incidence" is that Harry Truman – the President of the U.S.A. during the last moments of the War – was born precisely in a 8th of May.
Considering the facts mentioned above, it is not difficult to arrive to, at least, one conclusion.
Whatever criticisms one may have with regard to this or that theosophical organization – and there are many – it is a simple matter of common sense to admit that all of the movement, including Adyar Society, is naturally and intrinsically in favour of liberty and democracy, and against any disrespect for human life. The movement has an inherent tendency towards its main goal, universal brotherhood.
How the Vatican Gave Support to Adolf Hitler
In the paragraphs above, we saw that Nazism and Fascism persecuted the theosophical movement in every nation they dominated, both before and during the second world war. The movement only came back to normal life after Hitler and Mussolini were defeated by the democratic nations.
Let's now examine another side of the problem. What exactly were the relationships among the German Nazism, the Italian Fascism, and the Vatican?
There was an uneasy but intimate cooperation among the three. It started in the early 1920s, as author John Cornwell demonstrates in his well-documented book "Hitler's Pope – The Secret History of Pius XII" [20]. The Vatican also gave its decided support to the violent pro-Nazi dictatorship of Francisco Franco in Spain.
Eugenio Pacelli was the Pope's representative in Germany during the 1920s. He would later become Pope Pius XII. Pacelli played a key and central role in preventing German catholics, traditionally democrats, from resisting Hitler's political march to absolute power. Thanks to Pacelli, as soon as Hitler took the power in 1933 German Catholicism gave Nazism an active support. (Lutheran Church was already supporting the Nazis for some time.)
As to Italy, in 1929 pope Pius XI signed a comprehensive Agreement with the Fascist dictator Benito Mussolini. All of this confirmed the existence of strong mutual help mechanisms between the Roman Church and Nazi-Fascism.
It was no coincidence, then, that in 1930 Eugenio Pacelli left Nazi Germany to go to Rome and to work there as Secretary of State. In 1939, Pacelli was formally made Pope and adopted the name of Pius XII. John Cornwell reports that almost immediately after that Pacelli wrote a kind and friendly letter to Adolf Hitler, renewing his personal commitment to the "alliance between Church and State" in Germany, and saying he would remain "devoted to the welfare of the German people, which is under your guidance". [21]
Another Historian, Paul Johnson (who, by the way, is not the author of similar name who wrote books about the theosophical movement), writes about this:
"Pius XII, elected pope in March 1939, could hardly wait to send Hitler a friendly letter. He refused to condemn the absorption of Czechoslovakia a few days later, although he knew this meant the Czech Catholics (…) would immediately lose their schools. (…) In April 1939, Protestants and Catholics rang their bells [ in Germany ] for Hitler's birthday, and Cardinal Bertram, the Catholic primate, sent him a greetings-telegram." [22]
Adolf Hitler now had the blessings of the Vatican, and they opened room for him to deepen his policy of mass-murder, and to spread it around the world.
There was one group of Christians which resisted Hitler, though. It was the Jehova's Witnesses. Paul Johnson writes:
"They refused any cooperation with the Nazi state, which they denounced as totally evil. (…) Many were sentenced to death for refusing military service and inciting others to do likewise; or they ended in Dachau and lunatic asylums. One third were actually killed; ninety-seven per cent suffered persecution in one way or another." [23]
These, of course, are but a few data about the cooperation between the Vatican and Hitler. There are plenty of them available.
From a theosophical perspective, we should remember how radically H. P. Blavatsky and her Masters opposed and denounced the Vatican policies, and especially the Jesuits. It is enough to read about that in "The Mahatma Letters to A.P. Sinnett", especially Letter XXX in the Theosophical University Press edition [24]. In this letter, a comparison is made between the antagonically different methods used by the Jesuits and by the Himalayan Masters of the Wisdom. A Master writes in the Letter:
"As I once said before, they [ id est, the Jesuits ] know that what they teach is a lie; and we know that what we impart is truth, the only truth and nothing but the truth. They work for the greater power and glory (!) of their order; we – for the power and final glory of individuals, of isolated units, of humanity in general (….). They work, and toil, and deceive, for the sake of the worldly power in this life; we work and toil, and allow our chelas to be temporarily deceived, to afford them means never to be deceived hereafter; and to see the whole evil of falsity and untruth, not alone in this but in many future lives. They – the Jesuits – sacrifice the inner principle, the spiritual brain of the Ego, to feed and develop the better the physical brain of the personal and evanescent man, sacrificing the whole humanity to offer it as a holocaust to their Society – the insatiable monster feeding on the brain and marrow of humanity, and developing an incurable cancer on every spot of healthy flesh it touches. We – the criticized and misunderstood Brothers – we seek to bring men to sacrifice their personality – a passing flash – for the welfare of the whole humanity, hence for their own immortal Egos, a part of the latter, as humanity is a fraction of the integral whole, that it will one day become. They are trained to deceive; we – to undeceive (…)". [25]
This is how true Theosophy sees the Vatican and Jesuitism.
On the other hand, one cannot but perceive that there is an interesting "inner", essential connection between Hitler's Nazism and the Jesuits. This has been frankly described by the Jesuit historian Vincent A. Lapomarda in his book "The Jesuits and the Third Reich".
Quoting from various Nazi documents, Lapomarda seems to be almost proud to bring varied evidence on this point. He wrote, repeating the words of another author:
"Himmler modelled his SS so closely on the Jesuits that even Hitler called him 'my Ignatius Loyola'."
Lapomarda also reports:
"Himmler kept a medieval castle, the Wevelsburg, which served, so to say, as the SS monastery."
Quoting another author in the same page, the Jesuit admits:
"…Hitler not only regarded the SS as his Jesuit Order but insisted that these Nazis became familiar with The Spiritual Exercises written by St. Ignatius Loyola, the founder of the Society of Jesus." [26]
Two of the main reasons why the theosophical movement was persecuted both by Nazism and the Vatican were: 1) that it has been envisioned and created as a nucleus of the Universal Brotherhood; and 2) that the idea of Universal Brotherhood inspires its main declared object and the substance of its activities.
The Nazi military defeat was, therefore, a grave political defeat for the Vatican. Since the end of World War II, the Jesuits never regained the influence they had before, or during, the years when the Nazi-Fascist freely developed their criminal activities.
On the other hand, it has been a most fortunate and meaningful "coincidence" that the main theosophical goal, universal brotherhood, was clearly adopted in 1945 as part of the Charter of the United Nations Organization.
Since then it has been one of the main long term objects of the whole U.N. system – or perhaps the central one.
[1] "The Seventy-Fifth Anniversary Book of the Theosophical Society, A Short History of the Society (1926-1950)", by Josephine Ransom, TPH, Adyar, 1950, 252 pp., see pp. 106-107.
[2] "The Seventy-Fifth Anniversary Book of the Theosophical Society", p. 107.
[3] "The Seventy-Fifth Anniversary Book of the Theosophical Society", pp. 107-108.
[4] "The Seventy-Fifth Anniversary Book of the Theosophical Society", p. 109.
[5] "The Seventy-Fifth Anniversary Book of the Theosophical Society", p. 109.
[6] "The Seventy-Fifth Anniversary Book of the Theosophical Society", p. 110.
[7] "The Seventy-Fifth Anniversary Book of the Theosophical Society", p. 111.
[8] "The Seventy-Fifth Anniversary Book of the Theosophical Society", p. 111.
[9] "The Seventy-Fifth Anniversary Book of the Theosophical Society", p. 121.
[10] "The Seventy-Fifth Anniversary Book of the Theosophical Society", pp. 122-123.
[11] "The Theosophist", a monthly magazine, Adyar, India, vol. 97, No. 03, December 1975, p. 123.
[12] See for instance "Theosophy" editions for December 1940, p. 96 ; June 1942, pp. 382-383; August 1942, pp. 471-473; September 1943, pp. 481-484; January 1946, pp. 111-115 (on atomic bombs); February 1946, pp. 150-153 (also on atomic bombs).
[13] "United Lodge of Theosophists", Los Angeles, California, U.L.T. Letter dated June 25, 1941. See in our associated websites the compilation "The ULT Day Letters, 1931-1960", in PDF.
[14] "United Lodge of Theosophists", Los Angeles, California, U.L.T. Letter dated June 21, 1942. See in our associated websites the compilation "The ULT Day Letters, 1931-1960".
[15] "Blavatsky and Her Teachers", Jean Overton Fuller, East-West Publications, London/The Hague, in association with the TPH/London, copyright 1988, 270 pp.
[16] "Unholy Alliance: A History of the Involvement of the Nazi with the Occult", a book by Peter Levenda, mentioned in the magazine "Insight", the journal of the Adyar Theosophical Society in England, Spring 2006 edition, p. 30.
[17] "The Externalization of the Hierarchy", by Alice A. Bailey, Lucis Publishing Co., New York, Lucis Press Ltd., London, copyright 1957, fourth printing 1972, 744 pp., see p. 368. The whole book takes an activist viewpoint, strongly supporting the Allied and democratic countries.
[18] "Krishnamurti, The Years of Fulfilment", by Mary Lutyens, New York, Farrar Straus Giroux, copyright 1983, 248 pp., see p. 56. For more information on Krishnamurti and the Second War, look at pp. 49, 50, 51, 53, 54, 56, 57, 61.
[19] See also Chapter IX, Article 55, clauses (b) and (c). The Charter is published and widely distributed by the U.N. Its text can also be seen at the "Encyclopaedia Britannica", William Benton, Editor, 1967, volume 22, p. 570.
[20] Penguin Books, London, 1999. In the Portuguese language, see "O Papa de Hitler, a História Secreta de Pio XII", Ed. Imago, RJ, Brazil, 2000, 472 pp.
[21] "Hitler's Pope – The Secret History of Pius XII", Penguin Books, Chapter 12.
[22] "A History of Christianity", Paul Johnson, Penguin books, England, 1976, 556 pp., see p. 489.
[23] "A History of Christianity", Paul Johnson, Penguin books, see p. 489.
[24] T.U.P., Pasadena, CA, USA, 1992, see pp. 228-240. The same letter is numbered as Letter 74 in the Chronological Edition of "The Mahatma Letters", TPH, Philippines, 1993, 600 pp., see pp. 219-230.
[25] "The Mahatma Letters", see p. 231 in the TUP edition; and pp. 222-223, chronological edition, TPH-Philippines.
[26] "The Jesuits and the Third Reich", Vincent Lapomarda, The Ewin Mellen Press, Lewiston, Queenston, Lampeter, Wales, United Kingdom, 2005, 458 pp., see pp. 42-43.
On the role of the esoteric movement in the ethical awakening of mankind during the 21st century, see the book "The Fire and Light of Theosophical Literature", by Carlos Cardoso Aveline.
Published in 2013 by The Aquarian Theosophist, the volume has 255 pages and can be obtained through Amazon Books.


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Vlogging and the New DIY PR
December 4, 2007
(image: Andy Plesser shooting footage for The New York Times corporate site)
I've been talking to people in the industry about the fight for marketing dollars recently between interactive agencies, PR firms, and other consultants. Where PR people succeed and fail–and this was the main theme of the Critical Issues Forum–is in their ability to tell compelling stories. My theory is the overall nut of marketing dollars will remain the same, while PR firms fight to keep what they have, or learn new methods and take a bigger chunk. Creating new media, specifically producing video for the web is going to be the nut the industry fights for.
Ford Takes Social Media Release for a Spin
October 12, 2007
Since Tom Foremski's call for the death of the traditional press release, there has been a lot of chatter about the 'social media news release' (SMNR). Foremski's rational for writing the 'Die Die' post can be found in our interview with him.
The SMNR sounds complicated. It's basically a modern way to answer the who, what, when, where, and why using photos, video, links, and an RSS feed.
What's complicated is getting numerous departments at a company of this size–often with multiple agencies–to sign off on the text, let alone the web2.0 elements of an SMNR.
Ford's release for the 2008 Focus is a good example of an SMNR that quickly tells a story while being easy on the eyes. It helps journalists do their job, and makes blogging a snap (ty Bargainista).
So what? Ford is the most financially troubled of the Big 3 and has the most to gain by getting control of their message. Getting information in to the marketplace early and in a way that's interesting and palatable to the media and the blogosphere is a way to manage reputation. Their Autoshow blog is cool example of this.
An overview of how companies can benefit by open communication can can be found in Clive Thompson's naked WIRED cover story.
Planning on using an SMNR or elements of one? Let us know at prnewser at mediabistro dot com.


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At a bus stop café along a Southern Californian road, independent bus driver Johnny Chicoy readies his rickety old bus "Sweetheart" for the fifty-mile run to the mission in San Juan, Mexico. Before leaving, the darkly handsome Johnny quarrels with his tempestuous wife Alice about her drinking and lust for money. Soon after, the passengers arrive to begin their journey: Camille Oakes, a sweet blonde stripper on her way to a job in San Juan; Ernest Horton, a wisecracking traveling salesman; Van Brunt, a crotchety demanding old man in a hurry to reach San Juan; and Elliott and Bernice Pritchard and their rebellious teenage daughter Mildred. The bickering Pritchards are taking Mildred on the trip in hopes of breaking up her relationship with a boy back home. Joining them are bus stop employees Ed "Pimples" Carson, the young handyman and mechanic, and Norma, the star-struck waitress who dreams of being discovered in Hollywood. As a bulletin comes over the radio warning of an approaching storm, Camille pages through a girlie magazine and discovers that she has been slandered by an exposé. Disregarding the warning, the bus starts on its way, and Johnny, still angry at Alice, leaves her behind. As it starts to rain, the man-hungry Mildred begins to flirt with Johnny while Ernest amuses Camille by displaying the novelties he sells. The bus winds down the slick mountain roads until a massive landslide rumbles down the hillside, blocking the road and shaking up the passengers. When a highway patrol helicopter lands to inform Johnny that the main road to San Juan is closed, Johnny phones Alice to apologize, but when she answers, drunk and abusive, he decides to navigate the bus over the old road to San Juan and then leave Alice for good. As the bus embarks upon its bone-jolting ride, Pritchard spots the article about Camille and leers at her. Ernest, smitten by the alluring Camille and blissfully unaware of her profession, is kind to her and she basks in his benevolence. Seeing that the wobbly old bridge that spans the river is threatened by onrushing rapids, Johnny insists the passengers walk across. Once they are safely on the other side, Johnny guns the bus's engine, but midway across, a tree, swept by the violent current, smashes into the bridge, causing it to break in two. When the bus's wheels skid, Carson hurries to help free them, and Johnny safely reaches dry land. Meanwhile, at the café, the helicopter pilot, bent on taking advantage of Alice's unhappiness, makes romantic advances to her, but she rebuffs him. Chagrined, the pilot then offers to fly Alice to meet Johnny in San Juan. While lurching down a hill, the bus's water-soaked brakes fail, sending it crashing into a mud hole. While the passengers bicker and complain, Johnny goes to look for a farmer with a tractor who can extract the bus from the mud. When Johnny discovers that the nearest farmer will not return home until later that afternoon, he takes refuge in the barn from the teeming rain. Mildred, restless, follows and seduces him in the hay. Back at the bus, Pritchard observes to his wife that they are responsible for their daughter's maladjusted behavior. Once the rain stops, Camille and Ernest stroll through the fields and Ernest proposes. Later, Pritchard compliments Ernest for his conquest of Camille and shows him the exposé. Shocked, Ernest returns to the bus and wordlessly moves away from Camille. When the farmer finally returns, Johnny enlists his help, and on his trek back to the bus, realizes that he is still in love with Alice. Soon after, Alice arrives, and upon learning that Johnny has spent the afternoon with Mildred, is deeply hurt but nevertheless boards the bus to complete the journey to San Juan. Once there, Alice informs Johnny that she is leaving him and walks away. Camille is met at the station by the man who has hired her to strip, but when Ernest asks her to return to Los Angeles with him, she informs the man she is permanently retiring. Mildred, meanwhile, proceeds to the telegraph counter and wires her boyfriend that she is coming home to marry him. When Johnny learns that Alice has boarded the bus bound for Reno, he jumps in Sweetheart and follows her, and as the highway lights illuminate the bus's darkened interior, he sees Alice seated in the back. They then drive home together.
Cast & Crew
Additional Details
|MPAA Ratings:
|Premiere Info:
|New York opening: 5 Jun 1957
|Release Date:
|Production Date:
AFI-X* ;EBX; UCLA 16mm print
We gave our VID to EB 7 Jul 05
|Black and White
|Distributions Co:
|Twentieth Century-Fox Film Corp.
|Production Co:
|Twentieth Century-Fox Film Corp.
|United States
|not available
|not available
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Alec Antrobus 2015-09-17
I have read quite a few reviews of this film that either damn it with faint praise or are pointedly hostiile.In my opinion this is a fine film produced... MORE>
Bus of Fools?
DougieB 2012-12-08
I spent a lot of years wanting to see this before I got the chance. It's one of those movies that has enough real credentials to make it onto... MORE>
The Love Boat on wheels.
DougieB 2012-12-08
I haven't read the Steinbeck source material so I should probably refrain from being too snarky, but this kind of story has been done so many times... MORE>


text: The Women's Soccer team dropped a close one to Vermont on Thursday, losing three goals to one. For the Hawks, who fall to one and three in the conference, Lindsay Guidoboni scored the lone goal. Hartford travels to Stony Brook on Tuesday for their last regular season game.Back to Main Page


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Fri, 31 July 2015
On this episode I chat with Brooklyn-based freelance photojournalist Natalie Keyssar about her her work in Venezuela and Ferguson documenting political unrest. We talk about her path in photography and how she pursues the projects that interest her. Sit back, relax, and enjoy this episode of The Photo Brigade Podcast!
Direct download: 080_-_Natalie_Keyssar_-_Photo_Brigade_Podcast.mp3
Category:photography -- posted at: 9:21am EDT
Thu, 30 July 2015
On this episode Robert chats with his friend, photojournalist John Taggart, a documentary and editorial photographer based in Brooklyn, New York. They discuss his career and many recent projects including the Gay Pride Parade, Lower East Side building explosion, Baltimore race riots, and Eric Garner and Michael Brown protests in NYC.
Direct download: 079_-_John_Taggart_-_Photo_Brigade_Podcast.mp3
Category:photography -- posted at: 7:08pm EDT
Tue, 21 July 2015
On this episode Robert chats with Daniel Sullivan, a Maui, Hawaii-based photographer currently working on his second book about the ancient Kings Highway around the island. They talk about Daniel's beginnings as a photographer bouncing all around the world to document vanishing cultures. They talk about his gallery business he runs out of Paia where he and his wife Cara sell Daniel's prints, rugs and other items from his world travels, as well as clothing designed by his wife. Sit back, relax, and enjoy this episode of the Photo Brigade Podcast!
Direct download: 078_-_Daniel_Sullivan_-_Photo_Brigade_Podcast.mp3
Category:photography -- posted at: 11:27am EDT
Tue, 21 July 2015
On this episode Robert Caplin chats with PF Bentley a photojournalist, documentary filmmaker, and workshop instructor based in Hawaii. They talk about PF's nearly two decades as a contract photographer and White House corespondent for TIME Magazine covering politics during the Clinton and Bush administrations. They also discuss his transition into video and multimedia when PF was the lead instructor of the Platypus Workshops, which trained photojournalists in the world of videojournalism production. Sit back, relax, and enjoy this episode of The Photo Brigade podcast.
Direct download: 077_-_PF_Bentley_-_Photo_Brigade_Podcast.mp3
Category:photography -- posted at: 10:33am EDT
Mon, 22 June 2015
On this episode host Robert Caplin chats with Gail Mooney, Chair of ASMP and a veteran travel photographer. They talk about her career shooting assignments for the likes of National Geographic Traveler, transitioning to video, and the importance of professional organizations like ASMP. Sit back, Relax, and enjoy this episode of the Photo Brigade Podcast!
Direct download: 076_-_Gail_Mooney_-_Photo_Brigade_Podcast.mp3
Category:photography -- posted at: 12:11pm EDT
Mon, 22 June 2015
On this episode host Robert Caplin chats with travel photographer and destination workshop producer Mirjam Evers about her career, globetrotting, Photo Quest Adventures, Eddie Adams Workshop, and more! Sit back, Relax, and enjoy this episode of the Photo Brigade Podcast!
Direct download: 075_-Mirjam_Evers_-_Photo_Brigade_Podcast.mp3
Category:photography -- posted at: 12:10pm EDT
Mon, 1 June 2015
On this episode host Robert Caplin chats with his friend and sports shooter Brad Mangin who is based in San Francisco. Brad was in New York as part of his yearly trek to Cooperstown where he gave a talk on the History of Baseball Photography at the Major League Baseball Hall of Fame. They talk about Brad's career covering baseball out of the San Francisco Bay area and how he's begun publishing books on the San Francisco Giants' 2010 and 2014 World Series Champions as well as the first ever book published completely of Instagrams. Sit back, relax, and enjoy this episode of the Photo Brigade Podcast!
Direct download: BradMangin-PodcastAudio.mp3
Category:photography -- posted at: 11:16am EDT
Mon, 25 May 2015
On this episode Robert Caplin chat with a big personality in the photography world, Peter Hurley, founder and lead Shabanger at HeadshotCrew.com. They talk about his background as an olympic sailboat racer and fashion model for Polo and Abercrombie & Fitch, where he met his mentor, famed fashion photographer Bruce Weber, who encourage Peter to first pick up a camera. After developing his unique style and growing his confidence and client base, Peter has built his name into a brand. On top of it all he's created and leads a worldwide community of headshot photographers, speaks at workshops all over the world, has developed his own line of studio gear, and is putting out his first book: "The Headshot: The Secrets to Creating Amazing Headshot Portraits". Sit back, Relax, and enjoy this episode of the Photo Brigade Podcast!
Direct download: 073_-_Peter_Hurley-_Photo_Brigade_Podcast.mp3
Category:photography -- posted at: 12:59pm EDT
Mon, 18 May 2015
On this episode Robert Caplin chats with Boston-based photgrapher Rick Friedman. Rick's photos have graced the covers of many Newsweeks and various other publications. We talk about how he got into the world of photojournalism without a degree from a photography school and thrived as a freelancer for so many years. We talk business, networking, his workshops, and much more in this episode of the photo brigade podcast.
Direct download: 072_-_Rick_Friedman_-_Photo_Brigade_Podcast.mp3
Category:photography -- posted at: 9:40pm EDT
Mon, 11 May 2015
On this episode Robert Caplin chats with his friend, veteran New York Times staff photojournalist and editor, Jose R. Lopez. They talk about Jose's 31-year-long career at The Times covering major news events as a photographer and supporting many amazing staff and freelance photographers as an editor on various picture desks over the years! So sit back, relax, and enjoy this episode of the Photo Brigade Podcast.
Jose R. Lopez recently took early retirement from The New York Times as one of the 100 journalists that were offered the buyout from the Times company. In his 31 years as a journalist at The Times, he was a staff photographer for the newspaper for 16 years, which included an 8.5 year stint in the Washington bureau and covered the last three years of the Reagan administration, all four years of the Bush (41) administration and the first 1.5 years of the Clinton Administration. He returned to New York and continued to shoot a variety of assignments including 2 Olympics- 88 Winter Games in Calgary, Alberta, Canada, and the 96 Summer Games in Atlanta, GA, 5 Super Bowls, a couple of World Series, NCAA final four tournaments as well as other national and metro assignments. In December of 1995, he was sent to Bosnia Herzgovina to cover the end of the war there and the peace keeping duties that the American Military were going to take up as part of the Dayton Peace Accords. Lopez decided to become a picture editor as he felt he could better use his wisdom and talent in advocating for photographers work in the daily newspaper. He was a picture editor for the last 15 years of his career and worked on a variety of news desks. He was part of the team that won both Pulitzer Prizes in 2002 for the newspapers coverage of the Terrorist attacks of 9-11. His most recent assignment was picture editor of the digital platform, NYTNOW, the app of The New York Times. Over the course of his career, he was also an instructor in the New York Times Student Journalism Institute and taught the photojournalism aspect of this two week intensive in which 24 college journalism students, which include 4 photographers, are taught what it takes to perform at the level of a New York Times journalist. Many of his former students have gone to newspaper careers of their own as well as successful freelance careers. His time in the industry has provided him with a front row seat of the changes that the overall industry has gone through and continues to do. A native of Santa Fe, NM, he attended New Mexico State University where he holds a BA degree in journalism with a special emphasis in photojournalism.
Direct download: Jose_Lopez_-_Audio.mp3
Category:photography -- posted at: 10:18am EDT


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Product Update Mailing to Employer Groups
As you know, we are retiring some of our products effective December 31, 2013 in order to offer products that comply with federal health care reform.
In accordance with Department of Financial Services (DFS) regulations, groups will begin receiving letters that notify them of the upcoming retirement and recommend a replacement product that most closely matches the benefits of the retired product. The letter will contain rate information as well as 5 benefit out of pocket costs.
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- Research
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A note on common fixed points for -weakly contractive mappings in generalized metric spaces
© Bilgili et al.; licensee Springer. 2013
- Received: 20 May 2013
- Accepted: 18 September 2013
- Published: 8 November 2013
Very recently, Isik and Turkoglu (Fixed Point Theory Appl. 2013:131, 2013) proved a common fixed point theorem in a rectangular metric space by using three auxiliary distance functions. In this paper, we note that this result can be derived from the recent paper of Lakzian and Samet (Appl. Math. Lett. 25:902-906, 2012).
- fixed point
- partial metric space
- GP-metric space
1 Introduction and preliminaries
In 2012, Lakzian and Samet [1] proved a fixed point theorem of a self-mapping with certain conditions in the context of a rectangular metric space via two auxiliary functions. Very recently, as a generalization of the main result of [1], Isik and Turkoglu [2] reported a common fixed point result of two self-mappings in the setting of a rectangular metric space by using three auxiliary functions. In this paper, unexpectedly, we conclude that the main result of Isik and Turkoglu [2] is a consequence of the main results of [1]. The obtained results are inspired by the techniques and ideas of, e.g., [3–11].
Throughout the paper, we follow the notations used in [2]. For the sake of completeness, we recall some basic definitions, notations and results.
if and only if ,
Then the map d is called a rectangular metric and the pair is called a rectangular metric space (or, for short, RMS).
We note that a rectangular metric space is also known as a generalized metric space (g.m.s.) in some sources.
We first recall the definitions of the following auxiliary functions: Let ℱ be the set of functions satisfying the condition if and only if . We denote by Ψ the set of functions such that ψ is continuous and nondecreasing. We reserve Φ for the set of functions such that α is continuous. Finally, by Γ we denote the set of functions satisfying the following condition: β is lower semi-continuous.
Lakzian and Samet [1] proved the following fixed point theorem.
Theorem 1.1 [1]
for all , where and . Then T has a unique fixed point in X.
Lemma 1.1 [3]
Let X be a nonempty set and be a function. Then there exists a subset such that and is one-to-one.
Definition 1.2 Let X be a nonempty set, and let be self-mappings. The mappings are said to be weakly compatible if they commute at their coincidence points, that is, if for some implies that .
Theorem 1.2 [2]
Then T and F have a unique coincidence point in X. Moreover, if T and F are weakly compatible, then T and F have a unique common fixed point.
Remark 1.1 Let be RMS. Then d is continuous (see, e.g., Proposition 2 in [5]).
2 Main results
We start this section with the following theorem which is a slightly improved version of Theorem 1.1, obtained by replacing the continuity condition of ϕ with a lower semi-continuity.
for all , where and . Then T has a unique fixed point in X.
by replacing and in inequality (4).
which implies that and then . Consequently, we have as .
which implies that . So, we conclude that and hence as .
As in Theorem 1.1 in [1], we notice that T has no periodic point.
which implies that and then , a contradiction with . Hence, is a Cauchy sequence. The rest of the proof is the mimic of the proof of Theorem 1.1 in [1] and hence we omit the details. □
Inspired by Theorem 1.2, one can state the following theorem.
Then T has a unique fixed point in X.
Since the proof is the mimic of the proof of Theorem 1.2, we omit it.
We first prove that the above theorem is equivalent to Theorem 2.1.
Theorem 2.3 Theorem 2.2 is a consequence of Theorem 2.1.
for all . Due to the definition of θ, we observe that . Now, Theorem 2.2 follows immediately from Theorem 2.1. □
By regarding the techniques in [3], we conclude the following result.
Theorem 2.4 Theorem 1.2 is a consequence of Theorem 2.2.
Proof By Lemma 1.1, there exists such that and is one-to-one. Now, define a map by . Since F is one-to-one on E, h is well defined. Note that for all . Since is complete, by using Theorem 2.2, there exists such that . Hence, T and F have a point of coincidence, which is also unique. It is clear that T and F have a unique common fixed point whenever T and F are weakly compatible. □
Theorem 2.5 Theorem 1.2 is a consequence of Theorem 2.1.
Proof It is evident from Theorem 2.3 and Theorem 2.4. □
3 Conclusion
In this paper, we first slightly improve the main result of Lakzian and Samet, Theorem 1.1. Then, we conclude that the main result (Theorem 1.2) of Isik-Turkoglu [2] is a consequence of our improved result, Theorem 2.1.
The authors thank anonymous referees for their remarkable comments, suggestions and ideas that helped to improve this paper.
Authors' Affiliations
- Lakzian H, Samet B:Fixed points -weakly contractive mappings in generalized metric spaces. Appl. Math. Lett. 2012, 25: 902–906. 10.1016/j.aml.2011.10.047MATHMathSciNetView ArticleGoogle Scholar
- Isik H, Turkoglu D:Common fixed points for -weakly contractive mappings in generalized metric spaces. Fixed Point Theory Appl. 2013., 2013: Article ID 131Google Scholar
- Haghi RH, Rezapour S, Shahzad N: Some fixed point generalizations are not real generalizations. Nonlinear Anal. 2011, 74: 1799–1803. 10.1016/j.na.2010.10.052MATHMathSciNetView ArticleGoogle Scholar
- Aydi H, Karapınar E, Samet B: Remarks on some recent fixed point theorems. Fixed Point Theory Appl. 2012., 2012: Article ID 76Google Scholar
- Kirk WA, Shahzad N: Generalized metrics and Caristi's theorem. Fixed Point Theory Appl. 2013., 2013: Article ID 129Google Scholar
- Arshad M, Ahmad J, Karapınar E: Some common fixed point results in rectangular metric spaces. Int. J. Anal. 2013., 2013: Article ID 307234Google Scholar
- Sarma IJ, Rao JM, Rao SS: Contractions over generalized metric spaces. J. Nonlinear Sci. Appl. 2009, 2(3):180–182.MATHMathSciNetGoogle Scholar
- Arshad M, Ahmad J, Vetro C: On a theorem of Khan in a generalized metric space. Int. J. Anal. 2013., 2013: Article ID 852727Google Scholar
- Chen C-M, Sun WY:Periodic points and fixed points for the weaker -contractive mappings in complete generalized metric spaces. J. Appl. Math. 2012., 2012: Article ID 856974Google Scholar
- Chen C-M: Common fixed point theorems in complete generalized metric spaces. J. Appl. Math. 2012., 2012: Article ID 945915Google Scholar
- Di Bari C, Vetro P: Common fixed points in generalized metric spaces. Appl. Math. Comput. 2012. 10.1016/j.amc.2012.01.010Google Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text:
Sunday has rolled around again (are these Sunday's getting closer together or is it just me?) which means it's time for a ROW80 update.
ROW80 goals:
Goal 2: once goal #1 is achieved switch to editing mode on
the apocalyptic YA novel, The Utopians, aiming to edit ~ 5 pages half a chapter a day.
I had a great week this week, finally getting into the editing rhythm and completing a chapter almost every day. I'm now up to the start of Chapter 13 which means if I can manage to complete 5-6 chapters a week I will be done in less than 3 weeks.
Goal 3: keep up with my aim to read 50 books this year.
This week I read Matthew Reilly's new 3 part novella Troll Mountain. Now I'm a huge Matthew Reilly fan (I own every one of his books and even managed to meet him last year at a conference) but I have to say I was disappointed with this story. It was advertised as a family-friendly story, but perhaps should have been more explicitly sold as a Middle Grade novel. It was a quick read, full of action as always, but it just felt a little derivative.
Have you had a good week? Hitting those goals? I hope so 🙂
As always I love hearing from you.
Jody Moller


text:
PEI Vacation Accommodations and Cottage Rentals
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Reserve your next PEI vacation rental or beach house with us today! Contact Melanie via email or telephone.
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: This light, airy, beach-inspired, newly redecorated 3-bedroom and 2-bathroom cottage is located on and has direct access to Cousins Shore Beach, one of the most family friendly beaches on PEI.
The cottage features a striking 180 degree view of the Gulf of St. Lawrence from the surround deck and through the many large windows in the family room. Bonus - this PEI cottage, is just a short stroll to the popular and beautiful north shore beach. The family room - with cathedral ceilings, expansive windows, comfortable seating, patio doors to the deck, and a flat screen TV/satellite - creates a very cozy atmosphere for your family holiday. An updated kitchen/dining (which is open to the living area) offers a breakfast bar, table for 4, a full refrigerator, stove, microwave & dishwasher. The three bedrooms include a second floor master with queen bed (ensuite bath) and a great view of the Gulf. The second bedroom includes a queen bed and is adjacent to the main floor bathroom (also with great views of the Gulf via the large window). The third bedroom includes a double bed and is next to the main bath as well.
You are just 10 minutes to Kensington for all your shopping needs and the hub of Cavendish is just 20 minutes away. Ocean Villa is in Anne's Land - only 5 minutes away from the Green Gables Museum - and a stone's throw from the Lake of Shining Waters. Golf anyone? There is a nearby solution to every golfer's craving. Within a 25-minute drive, you can tee it up at 7 nearby courses.
Other amenities include a washer and dryer, towels, beach towels, linens, picnic table on the deck, adirondack chairs, BBQ, satellite, wireless internet and a fully equipped kitchen.
We know you will enjoy your stay with us on PEI so book soon to ensure you can take advantage of all of the conveniences of PEI Ocean Villa.
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Miles and miles of
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The North Shore is known as an area of great scenic beauty. This
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text:
As I wanted to simulate truncated normals in a hurry, I coded the inverse cdf approach:
truncnorm=function(a,b,mu,sigma){ u=runif(1) u=qnorm(pnorm((a-mu)/sigma)*(1-u)+u*pnorm((b-mu)/sigma)) return(mu+sigma*u) }
instead of using my own accept-reject algorithm. Poor shortcut as the method fails when a and b are too far from μ
> truncnorm(1,2,3,4) [1] -0.4912926 > truncnorm(1,2,13,1) [1] Inf
So I introduced a control (and ended up wasting more time than if I had used my optimised accept-reject version!)
truncnorm=function(a,b,mu,sigma){ u=runif(1) if (pnorm((b-mu)/sigma)-pnorm((a-mu)/sigma)>0){ u=qnorm(pnorm((a-mu)/sigma)*(1-u)+u*pnorm((b-mu)/sigma)) }else{ u=-qnorm(pnorm(-(a-mu)/sigma)*(1-u)-u*pnorm(-(b-mu)/sigma))} return(mu+sigma*u) }
As shown by the above, it works, even when a=1, b=2 and μ=20. However, this eventually collapses as well and I ended up installing the msm R package that includes rtnorm, an R function running my accept-reject version. (This package was written by Chris Jackson from the MRC Unit in Cambridge.)
Filed under: R, Statistics Tagged: Monte Carlo Statistical Methods, msm package, quantile function, R, rtnorm function, simulation, truncated normal
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text:
Helping Works
David Andrews concert to benefit Idaho Songwriters Association
Singer-songwriter David Andrews will perform an intimate evening of all-original writings at 7:30 p.m. Friday in The Sapphire Room, The Riverside Hotel, 2900 W. Chinden Blvd., Boise.
Andrews has been part of the national music scene for 25 years, drawing from roots of Americana and folk.
He will be joined by a small group of veteran players on this special night.
The event supports the Idaho Songwriters Association, a nonprofit organization committed to inspiring a more deeply connected community by providing a resource for songwriters to develop and share their craft.
The fundraiser will sponsor outdoor concerts, plus listening room concerts in The Sapphire Room and Cinder Wines. In addition, the ISA has scheduled a new program for 2017 — a "Sisters in Songwriting" concert series in The Sapphire Room featuring "in the round" performances by Idaho's female songwriters.
General seating is $15 and preferred is $20 in advance at eventbrite.com. Tickets are $20 and $25 at the door.


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Graced by beautiful spring weather in Washington, D.C., the AACR Annual Meeting 2017 brought together scientists from around the globe to share insights into the latest and most exciting cancer research. At the QIAGEN booth, our colleagues shared the latest in QIAGEN innovations, including the revolutionary QIAscout single-cell isolation system, and spoke to customers about NGS, liquid biopsy, bioinformatics solutions and more. They also presented, for the first time, the application note, "QIAscout CTC single cell isolation after AdnaTest CancerSelect pre-enrichment," which demonstrated a new method for high-quality single cell transcriptomics. Download your copy here!
The Spotlight Presentation on 4/4 featured guest speaker Monika Mehta, Ph.D, a Research Scientist from the Frederick National Laboratory for Cancer Research (FNLCR), and QIAGEN's own Strategic Marketing Manager Brian Dugan, M.S., MBA. More than 50 people attended to hear Dr. Mehta share her experiences with microRNA sequencing. In her role performing sequencing for the Center for Cancer Research, Dr. Mehta emphasized, data quality is paramount. While she and her team were happy with the kits they were already using for miRNA library construction, she noted that two aspects were limiting; the high sample input requirement of these kits, which could be up to 1 microgram, and the high RNA quality requirement of greater than a RIN value of 7.
To see if they could overcome these issues, her team performed a comparison between the kits they currently used for miRNA library construction and the pre-release and released versions of the QIAseq miRNA Library Kit. Using 4 normal and tumor samples of cellular miRNA, they found that QIAseq yielded increases in the number of miRNA mapped reads for all preps, and increases in the number of novel miRNAs. She also noted that RIN value didn't appear to affect the results, stating it's "not a good indicator of quality for miRNA." Her team also used the QIAseq miRNA Library Kit with exosome-derived miRNA, successfully preparing libraries and sequencing. She pointed out, "These are samples we couldn't have prepared using any other kit available to us right now."
Her research was followed by Brian's in-depth discussion of the QIAseq miRNA Library Kit, including the principle underlying the Unique Molecular Indices, molecular tags that enable quantification of mature miRNAs, and the unique chemistry that the kit uses to drive the reaction toward the miRNA size. He also noted that "The sample is important because it determines the amount of mapped reads you find," pointing out that mapping rates with the QIAseq kit tend to be 50-60% with cell lines, >75% from tissues, and 15–30% from serum/plasma. Another important note from his portion of the presentation focused around blocking hY4 Y RNA, a major contaminating RNA species in serum/plasma samples that accounts for a large quantity of the off-target reads found in this sample type. He showed data demonstrating that using no hY4 Y RNA blocker takes the percentage of "other RNA reads" collected from 2.5% up to a whopping 40%, and drops miRNA mapped reads from about 40% to about 25%, emphasizing the importance of blocking these contaminating RNA if your primary interest is miRNA sequencing.
QIAGEN's poster presentations covered a range of topics including circulating tumor DNA, RNA profiles of circulating tumor cells (CTCs) and extracellular vesicles (EVs), and RNA fusion detection in thyroid nodules. I listened to Corinna Keup, M.Sc. of the Department of Gynecology and Obstetrics, University Hospital of Essen, and Siegfried Hauch, PhD, Director of Liquid Biopsy and Site Management for CTC product development at QIAGEN, discuss the poster "RNA profiles of circulating tumor cells and extracellular vesicles for therapy stratification of metastatic breast cancer patients" with many interested visitors. The research presented demonstrated that even though CTCs and EVs are both types of liquid biopsy, they provide very different information. Dr. Hauch explained, "EVs give us an idea about the tissue; they are released from the tissue. But the CTCs cannot represent the tissue – they need to transform to escape the tissue." Indeed, their data from metastatic breast cancer samples showed markedly distinct gene expression profiles; only a few of the overexpression signals overlapped between CTCs and EVs. HER2 or HER3 related to therapy non-responders, but intriguingly, whereas mTOR in CTCs correlated to therapy responders, mTOR in EVs correlated to non-responders instead. The results highlight not only the utility of RNA profiling in liquid biopsy, but also the importance of recognizing the distinction between liquid biopsy sample types when analyzing these results.
It was exciting to see the advances being made in cancer research, and the promise of more success yet to come. Thank you to all the scientists and industry colleagues who came out to present at the AACR Annual Meeting 2017 this year for making the conference such a rich and interesting event! We will all continue watching with interest to see where today's research will lead.
Want to know more about the technologies presented at AACR? Check out our upcoming webinars! Browse the calendar


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Solomon is a trading division of Hebe Works Limited with offices in Leeds. Hebe Works is an award winning media and technology company, named as one of England's 50 most creative companies by Creative England during 2016.
Hebe's products offer people a deeper understanding of place. They include printed and online media, film, intelligent hardware and intelligence software.
In 2014, having helped Leeds City Council create Leeds Data Mill, the city's online repository for open data, our team set to work creating products and services that connected people with valuable, hyperlocal information like bin collection times and planning applications.
Building on the success of these early experiments with both location-aware technology and the use of open data, and with support from Leeds City Council, the Local Government Association (LGA), the Department for Communities and Local Government (DCLG), we consolidated our work into one central portal: a self-service dashboard for hyperlocal information.
Investors and partners
Thanks to an 18 month-long industrial research programme, supported by Innovate UK, Solomon grew into a highly functional, high performance, browser-based software platform for use on any sized screen. It has been designed with security and scale in mind, and takes advantage of the very best of modern web technologies. Furthermore, thanks to the work of a dedicated UX designer, Solomon is elegant and intuitive.
To-date, the Solomon platform has also been used to create prototype dashboard solutions for NHS England and Yorkshire Water. We believe that our team and technology's differentiating factor is the ability to provide users with access to information without requiring them to have prior experience of working with or interpreting data. Our aim is to transform data into "stories" that explain findings and provide insight with minimum effort on the part of the user.
In December 2015 we began talking to Leeds Business Improvement District about how the Solomon platform could create value for their organisation and customers. BIDs have a fixed window of opportunity (normally a five-year term) to demonstrate their value to the businesses who fund their work, before those businesses take a vote on whether the BID will continue to exist. There is a requirement, therefore, for a solution that empowers BID teams to organise and manage their data and present it back to customers and stakeholders in order to show accountability and highlight success.


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In the news
"The future will be whatever we make it, and we'll make it together."
Speeches on sustainable development
by Ralien Bekkers at the
United Nations
Imagining the future we (don't) want
Let me take you on a journey with youth around the world. I want you to put yourself in the shoes of an innocent young person.
Can you imagine, yourself struggling to stay alive? Living in danger and fear all day and night? Can you imagine, no access to the most basic needs, risking to die of hunger or thirst, or no access to toilets or tampons? Can you imagine, no education, skills or training? Or being abducted or shot on your way to school? Can you imagine, no employment? Not knowing what to do with yourself, with your life? Can you imagine, your livelihood threatened because of climate change, or having to escape your flooded home? And can you imagine, being the largest part of the population, but having no say in any decision being made about your life, your future, because of systemic corruption in your country?
Just imagine. And put yourself in the shoes of a young person, that lives like that, every day. This is not an exception. It is a very common reality, most likely far outside our comfort zones. Innocent children and youth all around the world are struggling right now. Suffering from crises and conflicts all around the world And soon, many more wars will arise over water, food and scarce resources. If we don't act NOW.
Let me take you back to the reality of the post-2015 negotiations. International youth through the MGCY (Major Group for Children and Youth) have been tirelessly involved in the process so far. Even though some progress has been made in the OWG (Open Working Group), reality is that over the past year, we witnessed unreadiness to outgrow linear growth, disregard of our sexual and reproductive rights, unwillingness to overcome fossil fuel addiction, disrespect of the earth's carrying capacity, and no consensus on peace, justice and human rights.
This is not the world I want. Nor any young person to my knowledge. Politics, profits and power are overruling people and planet. This is an unacceptable reality. In this perspective, my generation is one with poor prospects, and ending hope. Do you want that?
However, young people also possess endless potential, and we are drivers beyond this status quo. We, the young people, in all our diversity, are the future, and we are here right now. There are 1.8 billion of us. About 87% living in developing nations. And young people around the world areacting now. We are leading revolutions, we innovate, we solve challenges as social entrepreneurs. Young people are a significant as well as a neglected part of the solution. We are your greatest asset, if only… It is time to unite with the young people, it is time for you to reach out and include a new generation, acting together, harnessing the power of the crowd.
And let me be clear. We all owe it to the young people that are struggling, to do more than we could possibly imagine, to rise beyond ourselves. Going beyond the system as it is, doing what must be done. No longer quietly accepting what is truly not right.
Achieving this will never be possible, when working alone. This is not a one man's game. Influence comes only to those that collaborate. Build a strong connected network of civil society and new allies all around the world, focusing on lasting impact. Dare to be critical about others, as well as about ourselves, continuously trying to improve. We all need to get out of our comfort zones and show real courage. We will only win when united as nations, as organizations, and as people. Doing good is no longer enough. Post-2015 should be about doing better, together.
I could go on for hours. But we should really stop talking now, and start doing. And clearly, my time is up. Don't let us run out of time by talking too much. Because in reality, way more important than words, are bold actions. That is what will ultimately determine the future. And bold actions aren't going to be taken by somebody else. Those actions need to be taken by me and you. Yes, you. What is stopping you from doing more? Imagine standing in a young person's shoes. What will you change today?
Partnerships between generations
Last week I told my little brother that I would be far away from home for a conference about the future. "Can I please come with you?" he directly asked me. It struck me as a quite logical question. After all, it is his future too, isn't it? I explained how I would do the work for him this time. More importantly, I promised him that there would be a room filled with very important and intelligent people that would also have his best interests, and those of all other families around the world, at heart.
Isn't it actually strange that we are discussing youth here, without hardly any youth present in the room? That we are deciding about the future, without future generations being part of these discussions? It is good to talk about young people, but it is much more powerful and meaningful to talk with young people.
You will then find that young people share many of your concerns. And better, that we often have a clear view on how to achieve improvements. I am going to ask you urgently to give your attention to youth priorities such as education and employment, equality and good governance. They are high ranking on the younger generation's agendas.
In an ideal world we should not have to ask for help. But reality is, that many legal, policy and regulatory barriers hinder the meaningful participation and empowerment of young people to exercise and claim their rights. We must however put young people at the center of the design, implementation and monitoring of the future goals.
Meanwhile, I am most thankful to the governments of Australia, the Netherlands and the UK for the opportunity to speak. Although this statement does not represent the governments of the countries, it does represent the voices of their youth. But it also includes the ideas of tens of other young people from around the world, since they were actively involved in the open writing process of this speech.
In doing so, something became perfectly clear. We, as people, despite our differences and diverse cultures, should work together as one. We have to make sure that all cultures, all ages and all differences between people are recognized in the goals. Diversity is not a weakness, it is our strength. Youth is demonstrating it by working together, transcending national boundaries. Over and over again, our work results in common statements and solutions. It is possible.
We support strong and ambitious SDGs that not only promote a sustainable and safe world, but also tackle the problems that get in the way. I'm speaking of economic inequality and youth unemployment, weak governance structures, natural resource inefficiency and violations of human rights.
Recently, the High Level Panel did a good job putting young people at the center of the discussions but still needs to incorporate more youth focused indicators. We feel that the report provides a baseline for strong SDGs but should build on the work done by others including the Commonwealth Youth Development Index and the Major Group of Children and Youth in creating goals and targets, disaggregating data, and we should even consider a youth specific goal.
In addition, we must rethink the way that we approach development. We call on Member States to work towards a holistic approach, defining "well-being" that incorporates environmental and social considerations, beyond the economic focus of GDP.
First, the fast increasing numbers of youth unemployment are of major concern. We as youth should be educated to tackle current and future challenges. We must be equipped with new and sustainable skills that prepare for work. Not to search desperately, in some cases even for years, for a low quality job. Investment in quality education is of high priority and generates immediate and intergenerational paybacks. But only if governments prioritize creation of green and decent jobs, building a sustainably skilled workforce by increased investment, together with private sector, in order to enhance national ecosystems for youth enterprise.
Second, the new framework should make an explicit commitment to the meaningful inclusion of the most vulnerable and marginalized groups. We must remove the barriers they face for accessing basic services, economic opportunities, political representation, and human rights. Supporting equal opportunities and reducing social inequalities will lead to more sustainable societies. Investing in girls, for instance, is one of the single most effective interventions for reducing poverty. SDGs should ensure girls' access to education and health services, including sexual and reproductive health and rights, and promoting policies that empower their role in society.
And third, fair, responsive and accountable governance is among top priorities of young people around the world. We vow for a world where decision-makers have integrity, responsibility and are held to account. A world where governance systems are designed to take courageous decisions for long-term benefit. Truth is, nowadays many young people feel disempowered by the systems that are supposed to represent them. This creates distrust, which should be actively avoided. Let's face it: you do not only need us for designing these goals, but you will need us all the more to achieve them by 2030.
Unfortunately, none of the young people I spoke with in my country knew about this very "far away" process. Therefore we would like you to think of a way how to make sure that all children and youth around the world learn about and know the SDGs from 2015 onwards, and feel like they are part of it.
You can start now. Talk, listen and work together with us for the challenges of our futures. Here at the UN, and back at home. We must become partners and allies for sustainable development. The nuanced perspectives of youth on these issues can provide new solutions and mobilize youth as assets and problem solvers.
There is so much potential. Do you know that an Indian teen girl recently developed a super energy efficient 20-second cell phone charger? That a high school student in the USA designed the fastest and cheapest cancer detector ever? And that a 19-year-old boy from the Netherlands created a system to clean the plastic soup in the oceans? Also, Bill Gates & Steve Jobs created revolutionary innovations when they were only 21. Without these young ideas, we would never be where we are today. Youth innovations should play a prominent role in the new development framework. But it really is your task to stimulate and empower all of us, in order to become part of the solution. Only when we succeed in forming intergenerational partnerships right now, focusing on intergenerational equity and solidarity, we have a chance on real and long-term success.
Ladies and gentlemen, way more important than all the beautiful words are the actions that should follow from them. All young people, and families around the world, count on you and your actions. We look forward to actively working with you, to create and achieve the goals for our common, sustainable future. Because not only youth, but a partnership of generations, will be part of the solution.
?How old will you be in 2030
In 2030, how old will you be? I would be 38. I suppose I will be a mother by then. To begin, let me tell you about my future daughter. If we do our job right, she will know poverty only from the history books. She will learn that even though we once risked great environmental disasters and resource scarcities, we succeeded to realize effective strategies for sustainable development, which prevented her generation from what could have been a true nightmare. Regardless of the place in the world where she grows up, she will live in an environment completely free from any form of discrimination, an environment where young women like herself can fully participate and are leading important change, where all human rights are guaranteed, which includes access to any sexual and reproductive rights, an environment free from fear for conflict and disasters. Just like any other young person around the world, she will grow up in an environment surrounded by opportunities, including plenty green job opportunities for the young, and she can fully develop herself and her potential, so that she can soon meaningfully contribute to society. Because my and your generation showed her how to create necessary change and care for the earth. That is the world I want to leave for my future daughter. That is the world I want to create with you. But to create the future all people want and need, bold action is needed today.
Unfortunately in the world of today much still needs to change to unlock full potential of its young people but also of women, and to truly eradicate poverty and build sustainable systems and societies. The post-2015 development agenda must ensure both. In the world of today, young women my age and actually women of all ages are still sexually abused and violated - shockingly often - and they do not necessarily have the rights and freedom to make informed choices about their own lives and bodies. In the world of today, young girls - it could have been my 9-year-old sister - are still forced into child marriage. In the world of today, my 7-year-old brother could have been a child soldier or undergo harmful child labor. In the world of today, we have the greatest ever population of young people, but in many places we have only little if no real say in our own future, while for us most is at stake. This is what happens today and keeps us from developing our societies to the fullest. Remember that what we let happen to children and youth elsewhere, could have been your family too.
Before 2030, everyone must be truly equal. We need young people's and women's leadership to push this agenda forward. We need to see significant increases in women and young people in the real decision-making processes, also those behind closed doors and in comfortable backrooms. Moreover, isn't is about time that we appoint a female Secretary General, and what about a female PGA? Nothing against the great work that his excellencies have done so far, of course =) Women and young people are key to making sustainable development a success - we must be equal partners. It's young people and women we need to invest in today, as we are the economic potential and social capital we need for the world of tomorrow.
Even though the post-2015 goals will probably only last until 2030, their effect must go beyond. In those 15 years we must lay a basis for true transformation, on which my and next generations can build. We need to have a long term view on the development of the world. In 2030, we will be facing huge environmental risks from climate change, water scarcity, ocean acidification, deforestation, biodiversity loss, and ecosystem degradation. We cannot afford to jeopardize the planet and the lives of future generations, only to achieve short term profits and satisfy short term interests, leaving a world behind where new drivers of poverty are existent.
Short termism however, is what our current economic and political system is largely based on. This can and must be tackled by reversing current perverse and unsustainable economic incentives, eliminating all direct and indirect fossil subsidies as soon as possible, pricing external social and environmental costs of economic activities, taking serious the pollutor pays principle, moving beyond GDP, and transforming our outdated linear growth model into circular economic systems, which includes for example zero waste, smart resource usage and cradle to cradle strategies. What we need is better quality growth with less damage to the natural environment. It is possible to create a new, sustainable and equal economy, and many young people are already leading the way on local levels, if only we dare to change.
Also we should seriously look at our investment choices. At this moment young people around the world are campaigning not to invest, but to divest from fossil fuels. The so-called carbon bubble poses huge financial risks for the future. We can't keep valuing fossil fuels that should stay in the ground (that means two-thirds of all current reserves) in order to achieve the 2-degree climate change target Parties agreed to under the UNFCCC. And that whilst two degrees warming in general will already have severe and unequal impacts for many people, especially in the most vulnerable areas. We don't need fossil fuels to survive. It's rather the opposite. There are planetary boundaries which have to be included and tipping points that we can not cross, and which we are fastly approaching if we don't turn things around quickly. Not only are there many unsustainable incentives that push in the wrong direction, we are literally discounting future generations in economics, as we undervalue the future in calculations by using an unequal discount rate. The future is simply worth less. So in that sense, there's no need to take long term action or to invest in the future because everything today is worth more anyways. The value of future generations should at least be equal to that of our generation. We undervalue the future, but overcalculate profit from unrenewable resources, and in addition, costs of inaction on for example climate change continue to increase year after year. Today's youth and future generations will inequitably suffer the costs, but also the dangers, fears, and increased risks.
We can no longer procrastinate. If we want true sustainable development, we should strongly integrate the needs of young and future generations in the post-2015 agenda. We need somebody to step up for them, like the Ombudsperson from Rio+20. We need long termism and not only look at the past and the present, but also at our shared responsibilities in the future. From a youth perspective, I challenge but also urge you to move beyond the North-South divide, to think about the global commons and to create a universal agenda for global prosperity. You need each other in this, and we need all of you, to take action.
Caring about future generations means caring about tomorrow's young people. Caring about young people means caring about the future... well, you? The challenges we are facing, discussing, and want to solve, require effective and diverse partnerships in order to achieve the biggest impact. All groups, all stakeholders, all generations must be part of this agenda and find an active role in the implementation. But to get there, we must all feel the ownership. We need engagement and collaboration beyond the usual partners, strong empowerment of citizens, universal education for sustainable development - starting from the youngest age possible - and we need powershifts, men to women, and from the older to the younger. Both men and women should be able to make decisions. Both the older and the younger should be part of decision-making. We should do it together, create the common future together.
It is not possible to create an agenda and impose it on "the people" in 2016. We need to reach out to all of those not privileged to be here, and most of all listen to them. Not only do people desperately want to be included, we have to be included for post-2015 success. Because in case you haven't noticed yet, the time of top-down as we know it is over, that's not gonna save our world. We need the people in the communities, working on the ground level, ensuring implementation. Especially the next generation, their energy and innovative minds. Therefore active engagement needs to be strengthened and start now. We should use the post-2015 development agenda as a means to gain new trust in UN processes from people around the world, by giving them voice, space, and make them key part of the agenda. Without real people involved, words will be empty and goals can never ever be reached.
To make the post-2015 agenda inclusive and participatory for young people, we must ensure:
(1) that under every SDG focus area, specific targets or subgoals on youth are developed. Today's young people are more than willing - and probably the best ones to ask - to help you draft those.
(2) that the lead of countries such as Sri Lanka and the Netherlands is followed by others as well, and that Member States closely engage young people in national youth delegate positions, in the coming 18 months of the process and beyond.
(3) that after 2015, especially in the High Level Political Forum, young people and other non-political stakeholders are strongly included and are given a critical and central role, even though the name of the HLPF might suggests otherwise.
(4) we must also ensure that all the wonderful remarks made by Member States yesterday and today regarding the crucial role of young people for post-2015 development, will be reflected not only in this event but also in the OWG and the 69th session of the UNGA.
(5) that information and open data is provided so that the potential of the mass will be unlocked and can publicly overshadow the influential lobby from business as usual behind the scenes.
(6) and that back at home, we start an inclusive conversation about the role of the people in post-2015, to make them part and prepared to help taking on the challenges that the goals will bring once they are decided upon.
(7) and last, that all young people will be educated and aware of the sustainable development goals and the challenges of our generation, in which they all should be able to play an active role, for example as social entrepreneurs.
What concrete steps will you take, to work on intergenerational equity and justice, and include the young, in post-2015? Saying it is important is one thing - and the easy part - taking us serious in practice is less common. I mean, how many Member States brought young people here to talk and work with them, instead of talk about them? I look forward to hearing your concrete actions.
We OWE it to the people back home to do all that's possible - and more - to be inclusive. We OWE it to the people to create a truly ambitious and transformative agenda. We owe it to people everywhere in the world. Even though the political process might be tough, never forget that it should be about people's lives and not primarily about process and politics. And I know that many, many of you have doubts about political feasibility of a transformational agenda. While science tells us, that if we really want to and have enough willpower, we CAN do it, we can create the huge change that is needed. If you say that technological feasibility is there, but political isn't, it's you that has MUCH of work to do. Please, don't fail us. But work with us.
To conclude, when I spoke at the OWG in June last year on behalf of international youth from the Netherlands seat, I received amongst others a reaction from a youth organization in Kabul, Afghanistan which should not only be directed to me, but also to all of you. I quote: "We as a war-ravaged generation only struggle to learn from others and be part of a peaceful voice. We are hungry of education, development and prosperity, living alongside other nations and human beings in peace. We really need support of such you people."
Young people around the world need you to work together, to unite as a team, and we need you to work with us. You OWE it to all young people and those still to born into this world, to be bold. To be strong. To be courageous. To take long term responsibility. To be transformational and life-changing. We count on you, and you can count on us to join you -- if you let us.
I don't want your applause. I want your action. I don't need your praise. I need your politicians to take me and other young people serious. I am proud to be here with you. But I would much rather be proud of you. Proud that you promise me to do what needs to be done.