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The partnership is hoped to reduce costs and improve security.
Lexmark International has become the exclusive output provider to the Federal Bureau of Investigation (FBI) in a deal worth more than $30 million over a three-year period.
Lexmark's Print Management solution has been deployed across the FBI's optimised fleet of smart Lexmark printers and multifunction products (MFPs) to reduce unnecessary printing, control overall printing costs and provide for strong user authentication, data security and information assurance.
To further lower costs and increase efficiencies, nearly 20,000 printing devices currently in use by the FBI are being replaced with Lexmark's more efficient colour and monochrome printers and MFPs and connected to the FBI's cloud IT infrastructure.
Lexmark's Markvision Enterprise, advanced device management software for networked printers and MFPs, has been implemented to bring greater visibility and consistency to the FBI's newly optimised output environment in the form of robust monitoring and reporting capabilities.
Lexmark has delivered its Common Access Card (CAC)-enabled printing technology and solutions across 142 FBI locations nationwide in the USA as a subcontractor through Intelligent Decisions, a recognised leader in developing and delivering innovative federal IT solutions to the civilian, defence and intelligence communities.
With more than $2.5 billion in savings to date, Lexmark is on track to help the US federal government save $10 billion in costs by the year 2020 through a combination of innovative hardware and software technology that reduces printing and imaging expenses.
Marty Canning, Lexmark executive VP and president of Imaging Solutions and Services, said: "There is a reason Lexmark has a strong presence today in eight of the top 10 US federal agencies.
"We have built years of knowledge and expertise in the federal government arena, giving us an edge to put an effective output strategy in place that aids these agencies in running more efficiently while supporting their important missions and future initiatives."


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Zero byte download - C#
I'm from PicBackMan team, we are experiencing issues with Download photos/videos from SmugMug. Files are being downloaded but with ZERO byte, below is code block we are using:
string signature = myOAuth.GenerateSignature(uri, staticGlobalConst1.Smugmug_CONSUMER_KEY, staticGlobalConst1.Smugmug_CONSUMER_SECRET, tc.auth_Token, tc.auth_Secret_ticket_refresh, "GET", timeStamp, nonce, OAuth.OAuthBase.SignatureTypes.HMACSHA1, out normalizedUrl, out normalizedRequestParameters); string authorizationUrl = normalizedUrl + "?" + normalizedRequestParameters + "&oauth_signature=" + myOAuth.UrlEncode(signature); Uri signInUrl = new Uri(authorizationUrl); wc.DownloadFileAsync(Uri, path);
Please tell us what we are doing wrong here. We have received this issue from our users also.
Thank you for your response.
Saurav Anand Beginner grinner Posts: 13Registered Users Big grins
Just found that we could download public folder's photo/videos but not private folder's. Above mentioned code block was working for both public & private.
Please tell us some pointers so that we can fix this issue.
Thank you.0

subset: commoncrawl


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Akron, Ohio – July 1, 2010 Early on the morning of June 26, 2010, Honduras lost a son with great potential: Ian Henry Merriam Rubiano, 38 years old.
Known to family, friends and business associates as Ian Merriam, Ian was an entrepreneur in communications who also took great interest in the leadership of his country, following in the footsteps of his father, Henry Merriam, the Honduran architect, and Tegucigalpa mayor from 1976 to 1980, who in 2001 spearheaded real estate reform in Honduras, writing law and winning grassroots support.
Ian helped build E-Consulting S.A. as its co-president. E-Consulting provides communications services to Mexico, Central America and the Caribbean, linking rural regions unserved by broadband communications to the Internet. E-Consulting in Honduras provides financial institutions throughout country, ranging from large banks to savings & loan coops, with wireless access between ATMs and the home office. It also services the region's NGOs and the public sector, including public education and municipal county offices.
A graduate in business administration at Babson College in Massachusetts, majoring in entrepreneurial studies and marketing, Ian served on the boards of directors of the electronics retail chain Frontera Digital; Torre Vita, a real estate developer; and Macris School, the largest bilingual school in Honduras. Ian was honored as a CALI IV Fellow at the Central America Leadership Initiative, a non-profit foundation that seeks to motivate effective and responsible leaders across Central America.
Ian made friends wherever he went, and the team at VSAT Systems, his satellite service supplier in Akron, Ohio, USA, mourns his loss. Ian was an honorable and trustworthy business partner, a man for whom a handshake was as good as a signature, and one who gave his word as his bond. His upbeat, positive attitude was a blessing, and he will be missed.
- The VSAT Systems Family
SOURCE VSAT Systems, LLC.
CONTACT: Media, Michael P. Kister, President, +1-330-564-2147, email@example.com,
or Gordon Landefeld, Marketing Analyst, +1-330-564-2147, email@example.com
both of VSAT Systems, LLC.
Web site: http://www.vsat-systems.com/


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Posts Tagged 'orthodox'
Renters are running out of time!
November 30th is the deadline for first time buyers to take advantage of an up-to-$8000 tax credit when buying a home. This tax credit, coupled with current low interest rates and prices that have fallen up to 20% since late 2007, have created the best buyers' market in 30 years.
But all good things really do come to an end. Because it typically takes at least 30 days to close a purchase, first-time buyers are down to their last 38 days to benefit from this incredible buying incentive.
If you know someone who is wasting their money on rent and could benefit from this extraordinary opportunity, please let us know. Rest assured, we'll do everything we can to help them!


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Valeria Watson
Follow us
Mixed Media, performance art, couture fashion, immersive installations. 207 Coxe Ave, #4 Asheville, NC
My Art
Mend Make Market
Zamani Refuge Center
Up Coming Events
Stay Connected
Let's Share Space...
Designing African centered crafts, textiles and adventures.
Over the next few years I will be focusing on creating a space for like minds to congregate on the land that I own in Asheville, North Carolina. We have a list of needs like a Bobcat tractor, goat fencing and chicken coop building. I am encouraging all able bodies to join me and Brit in holding sacred space together on this land. There are many ways that you may be able to assist in these efforts. I welcome you to contact me with any ideas you have or ways you believe you may be of service. Thank you so much! ~Yeye
Fall Equinox Drumming Circle
& Website Launch Celebration
Come celebrate the launch of my website
Yeye style, with drumming and dancing around a fire this Fall Equinox. You are welcome to come for the festivities and bring a tent! Stay the night with us camped out under the stars!!
Spring Equinox Drumming Circle
& Barn Raising Celebration
The goats are currently too close to the house. At this weekend gathering we will be building a new home for the goats and preparing the land for community to begin building on the land. Anyone who is invested in creating sacred space to commune with elevated spirits is invited to join us on this exciting journey.
Summer Soltice Drumming Circle
& Temple Raising Celebration
This will be a very important occasion as we build the temple this weekend and scout spaces for other dwellings on the land. The overall vision is for there to be a barn, a temple, a museum, cabins and a camp area. Come help us bring this intention to fruition!
All The Places You May Find Me...
Sep 22
Local Cloth's Project Handmade 2016
September 22, 7:00 PM Local Cloth's Project Handmade 2016 Elements of Nature at the Folk Art Center on the Blue Ridge Parkway in Asheville, NC. milepost 382 BR Pkwy
Dec 1-Jan 29
Perhaps She Has a Pink Vest
Dec 1, 2017-Jan 29, 2018 the Refinery 207 Coxe Asheville, NC 28801 New Work by Valeria Watson. An installation inspired by a short story by Wolfgang Borchert.
Fall Equinox Drumming Circle & Web Launch
Come celebrate the launch of my website and E-Market, Yeye style, with drumming and dancing around a fire this Fall Equinox.
Sep 8-11
Goombay 2016 Art Exhibit Sept 8-11
The Goombay Art Show will feature works by Jenny Pickens, Joesph Pearson, Valeria Watson, Thomas Davis, Victor Palamino, and Chris Corral.
The Refinery Creator Space GRAND OPENING
Grand Opening for The Refinery Creator Space on Thursday, September 29 from 5:00 - 8:00 pm. 207 Coxe Avenue, Asheville, NC 28801
Black Bone: Affrilachian Poets and Visual Artists
Black Bone: Affrilachian Poets and Visual Artists January 13 – February 13, 2017. The Morlan Gallery will honor the Affrilachian Poets and visual artists with an opening reception, a release party for anthology "Black Bone," and a reading. Morlan Gallery, Transylvania University, 300 North Broadway, Lexington, KY 40508
March 30
Chit Chat: Nina Simone Zenobia Studio 6-9:00344 Depot St. Asheville
Come celebrate the Spring Equinox and with fashion designs by Valeria Watson and Jewelry by Viola Spells. Cudos to our photog and model Dustin Chaboudy and Credella Credelle.
...PastEvents and Spaces I have Been
Mothers For The Earth Gathering
A gathering of Mothers and Daughters of the Spirit. A Healing family of Wise Women and Daughters united for our personal and planetary healing, abundance and Joy.
Hillcrest School supplies distributed
Back to school distribution of supplies at one of the public housing locations in Asheville. Activist and artist Dwayne Barton and I chat about building community.
Young Struggle, Zamani Refuge collaboration
Young Struggle Members and Zamani Refuge meet to stratigize. After Black Lives Matter initiated their meetings at the Zamani Refuge African Culture Center; we united to begin to dismantle the dysfunctional relationships in our community. We have united to stabilize our finances and to create items for sale through Mend Make Market Affrilachia.


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1 & 2 Hour Pony Treks
1 Hour Private Hack - £35.00
2 Hour Private Hack - £55.00
1 Hour Griup Hack - £30.00
2 Hour Griup Hack - £50.00
4 Hour Pony Trek
Adult - £72.00
Payment by Credit or Debit Cards.
Severnwye Farm is the base for Severnwye Equestrian and Severnwye Llama Trekking.
Over 15 years we have built up a centre with rare breeds, wild boar, llamas, giant rabbits, horses, ponies, mules and donkeys.
Over the last year we have built indoor stabling and a large training arena for the equestrian operations. These include livery and pony trekking.
We welcome visitors to Severnwye Farm, and those using the facilities or coming on treks in the forest can also see the other animals we have.
Treks from Severnwye Farm through the ancient Forest of Dean.
Horses and ponies available to suit all sizes and levels of riding ability.
Treks can also be accompanied by Llamas, who will carry a large picnic hamper.
Severnwye has a Riding Establishment Licence from the Forest of Dean District Council for 2016.
Alastair & Moira Fraser
Severnwye Farm
Spout Hill
Tel: 01594 528482
Mob: 07929 372933


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The 43-year-old took the helm at Turf Moor in June 2004 after previously managing Cheltenham and Stoke and working under Howard Wilkinson at Sunderland.
A statement from the Clarets, who currently lie 15th in the Championship, said: "Burnley Football Club confirm that first team manager Steve Cotterill has left the club by mutual consent."
Copyright (c) PA Sport 2007, All Rights Reserved.


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For the handful of you with Windows Phone 7 handsets, get ready to wet your pants: the final version of Mango, Windows Phone 7.5, has leaked. You can install it on your phone right now.
It's reckoned that installing the Mango update will take a couple of hours, though – as always with these things – proceed at your own risk. If it goes boobs-up, you're very much on your own. For full instructions and a link to the update, head over to xda-developers.
The update is available to those already running a beta version of Mango, and users with 7392 – that's the post-NoDo security update.
The final version of Mango was delivered to networks and manufacturers at the end of July. There are rumours that the official Mango release could be as early as September 1.
Microsoft claims that Mango introduces no less than 500 new features, including enhanced multitasking, threaded conversations, and IE9 with HTML 5 support.


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Orange Coast League finals
COSTA MESA — Estancia High's No. 1-seeded doubles team of Matt Thomas and Robert Marroney and its No. 2 doubles team of Erik Cerros and Sterling Gates advanced to the semifinals at the Costa Mesa Tennis Center on Wednesday.
Both teams had opening-round byes and easily won in the quarterfinals.
Costa Mesa's doubles team of Michael Nguyen and Jose Cuevas also advanced to the semis. The duo will face Cerros and Gates in the semifinals on Thursday at 2 p.m. at the Costa Mesa Tennis Center.
Estancia's Joseph Kidane qualified for the semifinals in singles action. He dropped only one game during his two matches on Wednesday.
Sunset League finals
SEAL BEACH — Newport Harbor High sophomore Reese Stalder, seeded No. 2 in singles, won his first two rounds on Wednesday at the Seal Beach Tennis Center to advance to the semifinals.
Stalder earns the opportunity to compete in the semifinals on Thursday at Los Alamitos High. First serve is 1 p.m.
Newport Harbor's Sean Perrier and Garrett Byers, seeded fifth in doubles, lost in the quarterfinals.


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The deadline approaches. To receive April's book, you must be a member by midnight April 29th. The email will go out on the 30th. This month's book will be a complete surprise, so become a member or you'll miss it!
Thank you:
I have received some very nice comments and reviews from my readers lately. Those are super-encouraging and VERY appreciated.
Sales Prices:
THE GIRL IN THE PINK BIKINI (Coralee Chronicles) Book 1 is now 99 cents at Amazon and FREE at all other websites. I hope to make it free at Amazon as well, but that takes time and patience.
For a list of my other prices, visit www.feelgoodromance.com.
My Next Release:
This is what he wanted. This right here. He'd not known it until now, but he wanted her with a ring on her hand, their hearts united. He wanted Mrs. Jared Flint to stare at him like Holly did, to make him want to forgo breakfast and make love to her instead.
Jared Flint struggles to overcome his spotted past and put his years in prison behind him, slaving away beneath the Texas sun. Yet, hard work has done little to abate his ever-present anger. With every brawl, he strikes back at his abusive past, unable to turn loose of the hate that almost took a man's life.
Holly Carleton hopped a train on a dare and headed south. After her mama's passing, she's been rudderless, always searching for that one thing to fulfill her. Taking a job at a ranch at one of the towns along the tracks comes on a whim. But walking in on cowboy, Jared Flint, half-dressed – that was accidental. And something she'll never forget. He's strength and brawn in a perfectly carved package.
The days passing, their attraction growing, it becomes clear, he's held aloof from relationships for a reason. No woman deserves a man like him. Except together, they have a future rich in possibilities, and if he can just turn loose of the pain, a chance for forgiveness and love.
A contemporary western by author, SUZANNE D. WILLIAMS. 32,000 words.
Suzanne D. Williams
Florida, USA


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I set myself a challenge in the middle of last month, to not go grocery shopping again except for beer for my mom. How did I do?
On land, you might be used to thinking about "refrigerator" and "ice box" as interchangeable terms. They're both capable of keeping things cool - but both need an external resource to work. Which it is depends on your choice. Be sure you know what you have!
When you have a bunch of stuff that might be useful to someone but it's bulky and maybe not good for much, what do you do?
Communications on board is not quite as simple as grabbing the cell phone and dialing a number. Sea-Tech Systems cruiser-owners Devon and Rich Anderson share their tips and thoughts with me!
Somehow May snuck up on me. When I look back and try to choose a photo of the month, it's clear where April disappeared. That blur of activity? Yikes!
Wiring. It's how we make it all work!


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Half-Hour Quotes (displaying: 1 - 25 of 25 quotes )
I blame myself without reserve for my weakness. It was merely weakness. One half-hour with Art was always more to me than a cycle with you. Nothing really at any period of my life was ever of the smallest importance to me compared with Art. But in the case of an artist, weakness is nothing less than a crime, when it is a weakness that paralyses the imagination.
It had occurred to me to follow her through into the next room, visitors or no visitors, and bring her back for a talk. But in the end I had decided in favour of waiting where I was for her return. Sure enough, a few minutes later, Sophie had come back into the room, but something in her manner had prevented me from speaking and she had gone out again. In fact, although during the following half-hour Sophie had entered and left the room several more times, for all my resolve to make my feelings known to her, I had returned to my newspaper with a strong sense of hurt and frustration.
After dinner the babies get fussy and Min puts a mush of ice cream and Hershey's syrup in their bottles and we watch The Worst That Could Happen, a half-hour of computer simulations of tragedies that have never actually occurred but theoretically could. A kid gets hit by a train and flies into a zoo, where he's eaten by wolves. A man cuts his hand off chopping wood and while wandering around screaming for help is picked up by a tornado and dropped on a preschool during recess and lands on a pregnant teacher. ("Sea Oak")
It's no good. I've been trying to sleep for the last half-hour, and I can't. Writing here is a sort of drug. It's the only thing I look forward to. This afternoon I read what I wrote... And it seemed vivid. I know it seems vivid because my imagination fills in all the bits another person wouldn't understand. I mean, it's vanity. But it seems a sort of magic... And I just can't live in this present. I would go mad if I did
I like idling when I ought not to be idling; not when it is the only thing I have to do. Thatis my pig-headed nature. The time when I like best to stand with my back to the fire, calculating how much I owe, is when my desk is heaped highest with letters that must be answered by the next post. When I like to dawdle longest over my dinner is when I have a heavy evening's work before me. And if, for some urgent reason, I ought to be up particularly early in the morning, it is then, more than at any other time, that I love to lie an extra half-hour in bed. Ah! how delicious it is to turn over and go to sleep again: "just forfive minutes." Is there any human being, I wonder, besides the hero ofa Sunday-school "tale for boys," who ever gets up willingly?
Women never have a half-hour in all their lives (excepting before or after anybody is up in the house) that they can call their own, without fear of offending or of hurting someone. Why do people sit up so late, or, more rarely, get up so early? Not because the day is not long enough, but because they have 'no time in the day to themselves.' 1852
Is growin' up always miserable?" Sonny asked. "Nobody seems to enjoy it much." "Oh, it ain't necessarily misearble," Sam replied. "About eighty percent of the time, I guess." They were silent again, Sam the Lion thinking of the lovely, spritely girl he had once led into the water, right there, where they were sitting. "We ought to go to a real fishin' tank next year," Sam said finally. "It don't do to think about things like that too much. If she were here now I'd probably be crazy again in about five minutes. Ain't that ridiculous?" A half-hour later, when they had gathered up the gear and were on the way to town, he answered his own question. "It ain't really, " he said. "Being crazy about a woman like her's always the right thing to do. Being a decrepit old bag of bones is what's ridiculous.


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Do You Qualify for Startup Business Loans?
You're a brand new business—it wouldn't make sense to require any time in business, right? Right.
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You're credit doesn't have to be squeaky-clean. As long as you have 620+ FICO, we should be able to help!
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National has revolutionized the startup business funding process by simplifying the application and eliminating unnecessary paperwork, giving you the ability to secure financing in as little as 1 week. Call National's financing advisors at (877) 482-3008 to ask how your new business can benefit from our many startup business funding options, and prepare for your new company's future.


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- Research article
- Open Access
Melatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathways
© Liu et al.; licensee BioMed Central Ltd. 2013
- Received: 31 August 2012
- Accepted: 11 December 2012
- Published: 7 January 2013
Melatonin, a hormone-like substance involved in the regulation of the circadian rhythm, has been demonstrated to protect cells against oxidative DNA damage and to inhibit tumorigenesis.
In the current study, we investigated the effect of melatonin on DNA strand breaks using the alkaline DNA comet assay in breast cancer (MCF-7) and colon cancer (HCT-15) cell lines. Our results demonstrated that cells pretreated with melatonin had significantly shorter Olive tail moments compared to non-melatonin treated cells upon mutagen (methyl methanesulfonate, MMS) exposure, indicating an increased DNA repair capacity after melatonin treatment. We further examined the genome-wide gene expression in melatonin pretreated MCF-7 cells upon carcinogen exposure and detected altered expression of many genes involved in multiple DNA damage responsive pathways. Genes exhibiting altered expression were further analyzed for functional interrelatedness using network- and pathway-based bioinformatics analysis. The top functional network was defined as having relevance for "DNA Replication, Recombination, and Repair, Gene Expression, [and] Cancer".
These findings suggest that melatonin may enhance DNA repair capacity by affecting several key genes involved in DNA damage responsive pathways.
- Melatonin
- DNA repair
- Comet assay
- Genome-wide expression
- Network analysis
Melatonin (MLT), a hormone secreted by the pineal gland, plays an important role not only in the regulation of the circadian rhythm but also in the modulation of cancer risk by acting as an anti-inflammatory agent and an antioxidant (reviewed in [1, 2]). Recent epidemiologic evidence have pointed to an inverse relationship between night shift work and melatonin levels [3], which provides a possible explanation for the observation of increased breast cancer risk among female shift workers [4, 5]. By the same token, significantly decreased plasma melatonin levels have been found in patients with endometrial cancer [6, 7]. In animal studies, melatonin has been shown to inhibit the development of spontaneous and chemically induced mammary carcinogenesis [8], colon and hepato-carcinogenesis, [9], and carcinogenesis of soft tissue, the lung, the uterine cervix and the vagina [10–13].
In vitro functional analyses using cancer cell lines such as MCF-7 have been performed to investigate the effects of melatonin on cell growth, DNA synthesis, cell cycle, and apoptosis [14–17]. These studies have shown that melatonin may reduce MCF-7 cell proliferation by modulating cell-cycle kinetics, DNA synthesis, and apoptotic processes. Other studies have further demonstrated that melatonin can inhibit fatty acid growth-factor uptake [18] and telomerase activity in cancer cells [19]. The role of melatonin in DNA repair pathways was also recently documented in a study that showed a protective role for melatonin against oxidative DNA damage [20].
However, the impact of melatonin on DNA repair capacity for DNA strand breaks, the most common type of DNA damage, has not been previously examined using the comet assay, a reliable method for detecting and measuring DNA damage and DNA repair capacity [21]. Moreover, little is known about how melatonin affects expression of the genes involved in DNA damage response. In the current study, we performed both a comet assay and genome-wide expression assay using breast cancer cells (MCF-7) and colon cancer cells (HCT-15) to investigate the impact of physiological concentrations of melatonin on DNA repair capacity and expression of genes in DNA damage responsive pathways.
Cell culture and treatments
MCF-7, a human breast cancer cell line, and HCT-15, a human colon cancer cell line, were purchased from the American Type Culture Collection (ATCC, Manassas, VA ). MCF-7 cells were maintained as monolayer cultures in 25 cm2 polystyrene culture flasks (Falcon, Becton Dickinson BioScience, Le Pont de Claix, France) in Dulbecco's Modified Eagle's Medium (DMEM) supplemented with 10% fetal bovine serum, 1% penicillin-streptomycin (Invitrogen, Carlsbad, CA) and 0.01mg/ml insulin (Sigma-Aldrich, St. Louis, MO). HCT-15 cells were maintained in Roswell Park Memorial Institute (RPMI) 1640 media supplemented with 10% fetal bovine serum and 1% penicillin-streptomycin. Cells were incubated at 37°C in a humid atmosphere containing 5% CO2 and subcultured every 3~4 days.
Before each experiment, stock subconfluent monolayers of MCF-7 or HCT-15 cells were incubated with 0.25% trypsin-EDTA at 37°C for 3~5 min. MCF-7 cells were then resuspended in DMEM supplemented with 10% FBS and 0.01mg/ml insulin and HCT-15 cells were resuspended in RPMI 1640 media supplemented with 10% fetal bovine serum. Cell number and viability were determined by staining a small volume of cell suspension with 0.4% trypan blue saline solution and examining the cells in a hemocytometer. For all assays, MCF-7 cells were seeded at a density of 3~5×105 cells/ml in DMEM supplemented with 10% FBS, 0.01mg/ml insulin, and 1% penicillin-streptomycin for 24 hr (37°C, 5% CO2), and HCT-15 cells were seeded in RPMI 1640 supplemented with 10% FBS. After 24 hours, the media were replaced with fresh media containing either 1 nM melatonin (Sigma Chemical Co., St Louis, MO, USA), or the diluent (ethanol, final concentration 0.000005%) and cells were incubated for another 24 hours. Methyl methanesulfonate (MMS, mutagenic agent) (0.0125%, v/v, Sigma Chemical Co., St Louis, MO, USA) or PBS was added to the culture medium for an 1-hour treatment followed by an extra 3-hour recovery time in fresh medium. Cells were then harvested for the comet assay and RNA extraction.
Comet assay
DNA damage was assessed through the use of a comet assay that was first described by Östling & Johanson [22] and later improved by Singh et al. [23]. Following MLT and MMS/PBS treatment as described above, cells were harvested and mixed with 0.5% low-melting agarose [24] and fixed onto frosted slides pre-coated with 1.0% normal melting agarose (NMA). The slides were immersed in cold, freshly made lysing solution in the dark at 4°C for at least 1 hr and then rinsed with neutralization buffer to remove detergents and salts. Slides were then placed in a horizontal electrophoresis device at 4°C in alkaline buffer (pH>13) for 30 min to allow for DNA unwinding and expression of alkali-labile damage, followed by electrophoresis for 30 min (25V, 300mA), which allows damaged and/or broken DNA to migrate away from the nucleus. After electrophoresis, the slides were washed three times with a neutralization buffer. Slides were then stained with ethidium bromide (10 μg/ml), visualized by fluorescence microscopy, and analyzed using the Komet 5.0 comet assay analysis software which quantitatively determines the extent of DNA damage in each sample using the mean Olive tail moment calculation as previously described [25]. The head of the comet image consists of intact DNA, while the tail material is comprised of damaged DNA. Longer "tails" are associated with a greater accumulation of damage. Olive tail moment is defined as the function of the tail length and the precentage of DNA in the tail. Olive tail moment = (Tail.mean-Head.mean) X Tail%DNA/100. The mean Olive tail moment was determined for 200 cells (two slides with 100 cells per slide) from each of the four treatment groups (MLT, MLT+MMS, MMS, and Control) and all pairwise comparisons were examined using Fisher's PLSD.
Genome-wide expression microarray analysis
Genome-wide expression array analysis was only performed following MLT+MMS and MMS treatments. MCF-7 cells were harvested and total RNA was isolated using the RNeasy Mini Kit (Qiagen, Valencia, CA), with on-column DNA digestion, according to the manufacturer's instructions for mammalian cells. Genome-wide expression differences among MLT/MMS and diluents/MMS treated cells were determined by using the HumanHT-12 v4 Expression BeadChip, Illumina's latest whole-genome expression array system (Illumina, San Diego, CA). Samples were run in biological duplicate. Array hybridization and signal scans were performed by Yale University's W.M. Keck Foundation Biotechnology Research Laboratory. The images were analyzed using the Beadstudio software. Quality control and data analysis were carried out according to the instructions provided by Illumina. All array data have been uploaded to the Gene Expression Omnibus (GEO) database, and can be accessed via their website (http://www.ncbi.nlm.nih.gov/geo/; accession number pending).
Pathway-based network analysis
The set of differentially expressed transcripts was investigated for network and functional interrelatedness using the Ingenuity Pathway Analysis (IPA) software tool. Fold changes in gene expression were determined with the normalized signal intensities of probes from MLT+MMS treatment divided by the signal intensities from MMS treatment. The set of differentially expressed genes and their fold change values were inputted into the IPA program and used to identify interaction models of genes using the Ingenuity Knowledge Base, a manually curated database of functional interactions extracted from peer-reviewed publications (http://www.ingenuity.com). A Fisher's exact test based on the hypergeometric distribution was then done for each identified network to determine the likelihood of obtaining at least the same number of interrelated molecules by chance.
Statistical analysis
Statistical analysis of DNA damage repair capacity was performed using the Komet 5.0 comet assay analysis software. Differences in DNA repair were determined for all pairwise associations of the four treatment groups (MLT, MLT+MMS, MMS, and Control) using ANOVA Fisher's PLSD for the mean Olive tail moment with the SAS statistical software package, version 9.1 (SAS Institute, Cary, NC). The Student's t-test was performed to compare gene expression levels using normalized expression values from the Illumina expression array for the MLT+MMS and MMS treatment groups. Transcripts were identified as significantly influenced by MLT treatment if their expression differences fit the criteria of p<0.05.
Among the samples not treated with mutagen, the differences in mean Olive tail moments between cells in the control group and those in the MLT treatment group were not statistically significant for either cell line (p=0.976 for MCF-7, p=0.928 for HCT-15), indicating that without inducing damage, there is no difference in detected DNA damage levels. However, among the mutagen-treated populations, cells with MLT pretreatment had a significantly shorter mean Olive tail moment (p<0.0001 in both cell lines), as depicted in Figure 1B, indicating increased DNA repair capacity compared to cells without MLT pretreatment.
Functions and molecules in the top 5 networks of identified genes regulated by MLT
Focus molecules
Top functions
Molecules in network
DNA Replication, Recombination, and Repair, Gene Expression, Cancer
ARHGAP6, C15orf23, C2CD2, C2CD4B, CCNB2, CEP63, CEP152, CR2, DCAF11, DYNLL2, GTF2IRD2B, HNRNPD, INTS2, MCART1, miR-183, miR-548f/miR-548a-3p, N4BP2L2, NEIL1, PARP11, PCNA, PCYT1B, POLB, PRDX6, RBM47*, SPAG5, SPRY2, TET1, THEM5, TRAPPC1, UBE2, UBE2A, UBE2G2, WRN, XRCC1, ZNF264/ZNF805
Cell-to-Cell Signaling and Interaction, Cellular Movement, Tissue Development
ADARB1, APPBP2, ASAP2, CADM1, CRYBA2, DENND1A, FAM96A, FRK, GLDN, KIAA0907, LYPD1, MAP3K13, miR-450, miR-873, miR-450b-5p, miR-520d-5p/miR-524-5p, miR-548p, MUL1, NFASC, NPTN, PCSK5, PDE6D, RAD54B, RBM47*, SDHAF2, SHB, SLC16A9, STK10, TBL2, TCEB3, TET1, THSD7A, TMOD2, UBE2Q2, ZNF430
Cell-mediated Immune Response, Cellular Movement, Hematological System Development and Function
Acan, ALOX12, ANKLE2, C2orf27A/C2orf27B, CCDC90A, CDC42, CDK5RAP2, CILP2, CLEC2D, CMA1, CST3, CTSH, EIF5A, FN1, HP, IFI27, IL13, IL11RA, ITGAE, LLGL2, miR-29b/miR-29c/miR-29a, PLUNC, RABGGTB, RCC2, RPL5, RPL23, SFTPB, SLC23A2, SOCS5, SPAG4, STAT3, TGFB1, tretinoin, WDR92
Lipid Metabolism, Small Molecule Biochemistry, Cardiovascular System Development and Function
ATP, C17orf90, C1orf123, Ca2+, CCDC90B, DCAF11, DMC1, FPGS, FXYD6, G protein alphai, GABRP1, GBP3, GPSM1, GRB14, GTP, HIST1H2AH, HIST2H2AA3/HIST2H2AA4, HNF4A, miR-125a-3p, miR-1267/miR-582-3p, MRPS12, NOP16, P2RX2, P2RX3, P2RX5, P2RX6, PLCB3, PRDX5, PTK6, RGL2, RPL30, RPL18A, RTCD1, TAC3, THAP4
Cell Death, Cellular Development, Cellular Growth and Proliferation,
26s Proteasome, Akt, BEX2, BRAP, CLIP2, CXCL3, DYRK1B, ERBB3, ERK1/2, FER, HERP, HEY1, HRAS, IDE, IL17R, IL36A, Insulin, LDL, Mapk, miR-205, NFkB, Oas1h, Olfr1508, P38 MAPK, Pdgf, PDPK1, PI3K, Pvr, Rasgrf, RGS3, RPS6KA, SIRT4, TUBB, UTS2
This network consists of 36 genes, 16 of which exhibited altered expression following MLT treatment (ARHGAP6, C2CD2, C2CD4B, CEP152, GTF2IRD2B, INTS2, MCART1, N4BP2L2, NEIL1, PARP11, RBM47, TET1, THEM5, TRAPPC1, UBE2A and ZNF264/ZNF805). Among these genes are several with known roles in the regulation of DNA repair activity, including CEP152, a regulator of genomic integrity and cellular response to DNA damage through the ATR-mediated checkpoint signaling pathway [26]. Our results indicate that CEP152 expression was significantly upregulated following MLT treatment. Similarly, N4BP2L2 was induced after MMS exposure and higher N4BP2L2 expression was detected in MLT pretreated cells upon MMS exposure. N4BP2L2, which encodes a phosphonoformate immuno-associated protein, is phosphorylated by ATM or ATR upon DNA damage.
The protective role of melatonin in DNA damage response observed in our study is congruent with previous findings. Since melatonin was initially identified as a free radical scavenger in 1993, many studies have shown that melatonin may protect DNA against free radical damage [27–31] by stimulating antioxidative enzymes and scavenging ·OH radicals [32, 33]. In addition to stimulating DNA repair capacity, melatonin may aid in inactivating the DNA-damaging agent [34]. However, most previous studies have focused their investigation on the role of melatonin in protecting the cell against oxidative DNA damage. Our results demonstrate for the first time that melatonin may also increase DNA repair capacity against strand breaks caused by the DNA damaging agent MMS in vitro, as measured by the comet assay.
Although increasing evidence suggests a protective role of melatonin in the DNA repair pathway, the molecular mechanism of melatonin is still unclear, especially with regard to the potential impact of melatonin on the expression of DNA damage responsive genes. Our current study examined genome-wide gene expression affected by MLT upon MMS-induced DNA damage and found that melatonin can affect multiple DNA damage responsive pathways that are involved in several signaling pathways associated with DNA damage.
Upregulation of CEP152 and N4BP2L2 associated with MLT pre-treatment in our study showed positive activation of DNA repair capacity. CEP152 is a centrosomal protein involved in the maintenance of genomic integrity and response to DNA damage, acting as a scaffold facilitating the recruitment of PLK4 and CPAP to the centrosome to ensure a faithful centrosome duplication process [24, 34]. Increased CEP152 expression may facilitate DNA damage checkpoint control and ATR/ATM-mediated phosphorylation in response to accumulation of DNA damage [26, 35, 36].
It has been suggested that N4BP2L2 is phosphorylated at serine 199 as a substrate of the protein kinases ATM and ATR in response to DNA damage [37]. ATR is known to be involved mainly in responses to DNA single-strand breaks (SSBs), while ATM is activated in response to DNA double-strand breaks (DSBs). Since ATM and ATR both trigger an overlapping set of cellular responses that promote cell cycle arrest and DNA repair [38], it is suggested that MLT may activate multiple DNA repair processes through the increase of N4BP2L2 expression and induction of ATR/ATM-mediated damage responsive pathways.
While our data support melatonin's protective role in DNA strand breaks and illuminate potential molecular pathways by which this role is fulfilled, without the inclusion of additional experimental evidence, our conclusions remain quite exploratory. Future investigations should therefore make use of alternative strand break visualization technologies, including phospho-H2AX labeling, to provide confirmational evidence, assess the kinetics of MLT's effect on DNA repair, and measure the response in specific biological pathways to MLT induction at the protein level.
Our data support the hypothesis that melatonin may enhance DNA repair capacity and play a protective role in cancer development. Although the molecular mechanisms of melatonin in cancer-related biological pathways are still largely unknown, our data suggest that melatonin may participate in the regulation of several key genes involved in DNA damage repair pathways.
This work was supported by NIH grant ES018915 and funds from Yale University.
Authors' Affiliations
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Hong Kong's Underworld Explored with First Public Sleeping Dogs Demo
LOS ANGELES (Mar. 29, 2012) — Square Enix, Inc., the publisher of SQUARE ENIX® interactive entertainment products in the Americas, today announced its roster of games for this year's Penny Arcade Expo (PAX) East, set to take place at the Boston Convention and Exhibition Center (Booth #850), from April 6–8.
PAX East attendees are invited to preview and play the following Square Enix titles:
- Sleeping Dogs™ — the free–roaming, undercover thriller set in Hong Kong's Triad underworld will feature a playable demo that encapsulates the game's combat, narrative, driving and open world elements.
- THEATRHYTHM™ FINAL FANTASY® — the first–ever music–themed title that commemorates the FINAL FANTASY franchise's 25th anniversary merges rhythm and role–playing game genres.
- Quantum Conundrum™ — show attendees will be among the first members of the community to play the first–person environmental puzzle game from Airtight Games and Kim Swift, co–creator of Portal.
- HEROES OF RUIN™ — visitors who demo the epic action–adventure title for Nintendo 3DS™ system can receive a raffle ticket for a chance to win their very own Nintendo 3DS™ system; those who upload photos of themselves with hero weaponry props (available at booth) to their own Facebook page can earn another raffle ticket for the drawing.
- WAKFU® — the recently launched MMORPG from Ankama Studios offers attendees the chance to demo 12 available classes. Upon request, the first 1,500 visitors will receive an exclusive PAX East in–game item, as well as two weeks of free premium game time. Fans will also be eligible to spin the WAKFU Prize Wheel for a chance to win branded merchandise.
- Risen 2: Dark Waters™ — player decisions will help shape their world in the next installment of Deep Silver's open world RPG. Featuring a swashbuckling pirate theme, a hands–on demo awaits intrepid buccaneers at the Square Enix booth.
Additionally, Square Enix will host an exclusive evening panel, featuring a gameplay demo and Q&A session with IO Interactive for the much–anticipated fifth entry in the classic HITMAN® franchise, HITMAN: ABSOLUTION™. Panel details include:
- Speaker: Roberto Marchesi (Art Director, IO Interactive)
- Day / Time / Location: Saturday, April 7, 7:30 p.m. – 8:30 p.m., Manticore Theater
Finally, Square Enix will celebrate PAX East with a joint HITMAN: ABSOLUTION and Sleeping Dogs themed event at Boston's famed Faneuil Hall on the evening of Friday, April 6. A PAX East badge and legal identification will be required for this 21 and over event.
About SQUARE ENIX, Inc.
Square Enix, Inc. develops, publishes, distributes and licenses SQUARE ENIX®, EIDOS® and TAITO® branded entertainment content throughout the Americas as part of the Square Enix Group. The Square Enix Group operates a global network of leading development studios and boasts a valuable portfolio of intellectual property, including: FINAL FANTASY®, which has sold over 100 million units worldwide; DRAGON QUEST®, which has sold over 59 million units worldwide; TOMB RAIDER®, which has sold over 35 million units worldwide; and the legendary SPACE INVADERS®. Square Enix, Inc. is a U.S.-based, wholly-owned subsidiary of Square Enix Holdings Co., Ltd.
More information on Square Enix, Inc. can be found at http://www.square-enix.com/na/.
DRAGON QUEST, EIDOS, FINAL FANTASY, HEROES OF RUIN, HITMAN, HITMAN: ABSOLUTION, QUANTUM CONUNDRUM, SLEEPING DOGS, SPACE INVADERS, SQUARE ENIX, the SQUARE ENIX logo, TAITO, THEATRHYTHM FINAL FANTASY, and TOMB RAIDER are registered trademarks or trademarks of the Square Enix Group. RISEN 2: DARK WATERS is a trademark of Deep Silver, Inc. WAKFU is a registered trademark of Ankama. Nintendo 3DS is a trademark of Nintendo. All other marks are the properties of their respective owners.


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Greetings In The Name of the Lord:
Ephesians 5:21-24 (NLT)
21 And further, submit to one another out of reverence for Christ.
22 For wives, this means submit to your husbands as to the Lord. 23 For a husband is the head of his wife as Christ is the head of the church. He is the Savior of his body, the church. 24 As the church submits to Christ, so you wives should submit to your husbands in everything.
In this Sunday's message we are continuing our look at Love and Marriage from a Christian perspective. In doing so we need to deal with the issue of submission. Unfortunately this is a topic that is most often misunderstood both outside and inside the church. The following story gives one of those misunderstandings. Jill Briscoe had this to share about what submission is not. "Stuart and I brought our families and religious heritages to our marriage. My father, a quiet, gentle man, considered himself head of his home: protector, defender, and provider. My mom was a sweet, Scottish- born Presbyterian. She believed in the sovereignty of God and her husband. My father adored my mother, put his considerable business assets into her name, and looked to her to raise the children. When my sister came of age, my father supported her when she became an excellent car mechanic and raced cars. Eventually she took her place at his side as partner in his successful car business. Stuart's family was strict, conservative evangelical. His father was an elder in a small local assembly of believers, and he took seriously his responsibility to rule the household well. He considered himself the authority in his family, while his wife, a bright, articulate, efficient lady, considered herself in subjection to her husband in everything, carrying those convictions to her dress, her hair style, and silence in the presence of men at the church.
Newly converted at a college in Cambridge and having just been introduced to Stuart's family, I remember wondering greatly about this amazing mode of doing things. I sensed an unconscious frustration of unexplored desires and frustrated gifts in my mother-in-law. It was as if those gifts sat meekly inside her heart with eyes downcast and wearing a hat. In that moment as a new believer, I believe I stumbled on an important truth of what submission isn't. Submission isn't sitting down on the outside while you're standing up on the inside" (What Submission Isn't," Jill Briscoe, "Hilarious Hupotasso," Preaching Today, Tape No. 117). Something that we should notice about what Paul wrote to the Ephesian Church. He says we should "submit to one another out of reverence for Christ." We need to submit to one another because submission has to do with mutual respect and not keeping some under our thumb. It's not about lording it over someone; rather it is about showing the proper respect to one another because of our reverence for Christ and his Word. Once we figure that out we begin to submit out of love and not out of force.
In Christ,
Pastor Mark


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I finally read through what I have of A Fool's Errand (outlined). Then, just for fun, I compared it to Lost Among Shadows (starting point plus rough idea where I was going) and the first quarter of Chaos Unbound, my 2014 NaNo (pantsed). Despite its reluctance to adhere to my outline, I expected Fool to be the most consistent plotwise. If anything it's the least while Chaos is the most consistent.
If anything it's the least while Chaos is the most consistent. True, Chaos has its own share of problems. Like the threaded thin middle and an intentional Deus ex at the end, but even that doesn't fully come out of nowhere. It's hinted at throughout the story, but never properly set up.
It seems that A Fool's Errand isn't the story, I thought it was. I still want to write it, though. So, I'm going to scrap about 20k words and carry on from there. Once I've released Lost Among Shadows. That one "only" needs to be revised and I want to get it out sometime this year. So, they're trading places.


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By the Editor
This site has received some very nice compliments and comments since its introduction on August 2, 2011. Some include questions about our header graphics and contributors' caricatures.
The secret is out: They are the work of Mike Patrick, a very talented young artist located near my home base in north central Oregon.
Based in Portland, Mike is a twenty-something artist-cartoonist involved in several media projects. He specializes in animation, film, and caricatures, and is the creator of "Fun Sized" – a daily Internet-based cartoon about kids, parenting, and relationships. He also produces artwork and multimedia for several other sites in addition to Inside the Watchtower.
Mike is not a Jehovah's Witness and never has been, but has known a few personally. Working along with me on this website, he understands its purpose and theme. However, he is not a warrior for the cause, only a non-combatant contractor.
He cautiously admits that he grew up and graduated from high school in Lake Oswego, Oregon, and studied graphic design in Portland. Being a native Oregonian, Mike naturally enjoys the outdoors by both foot and bike, often overindulging in the lush local cuisine, and drinking espresso like it's tap water. In addition to managing his time to churn out a daily comic, he also takes care of two beautiful daughters along with his lovely wife.
Michael enjoys writing in the third person, and is working on a children's book and several short films. Check out this sample from one of his media projects:
To see more of Mike's work, I suggest you visit his websites at PatrickIllustration.com and FunSizedComics.com for samples of past and more recent projects from his portfolio.
Mike is open to business inquiries, questions, and even insults – should you feel the need. Contact him at: email@example.com.
Editor's Note: Not all of the graphics on this site are the product of Mike Patrick – only the good ones. For all of my websites I use a fair amount of public domain graphics and photos. I frequently have to fire up Photoshop to adapt some art and photography myself for unique illustrations. In spite of whatever talents I might have, I can assure you that there was a very good reason that I asked Mike to help me out in an effort to make this site truly different in look, and mood, from others focused on JW subject matters. Feel free to contact him if you are in need of support for any art, media, or book illustration project.


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Henson and Rivkin send note to employees
of Henson.com
The following letter was posted on Henson.com today from Brian Henson and Charles Rivkin:
We are pleased to share with you news of a very significant and very positive development in the long and continuing history of The Jim Henson Company.
Over the past few months, we have been reviewing a number of strategic alternatives for the Company that would enable us to build upon the extraordinary and unique business all of us have successfully created since The Jim Henson Company was formed forty-two years ago.
We have been exploring ways to accelerate our growth and, while remaining true to our mission and character, to become more of a major player in the entertainment industry. We want to ensure that we have the financial, marketing, and distribution horsepower we need to realize the tremendous potential of our people, our creative resources, our unique characters, our programming assets and our many business relationships. In short, we want to position The Jim Henson Company for continuing and growing success in the next forty-two years, and beyond.
Today, we are pleased to announce the culmination of that process, in a definitive agreement, announced this morning, under which The Jim Henson Company will be acquired by EM.TV & Merchandising AG, of Munich, Germany, one of the fastest-growing and most successful media, animated cartoon and retail companies in Europe.
EM.TV was founded in 1989 by Thomas Haffa, the company's extraordinarily dynamic and marketing-savvy chief executive, and has been a public company since October 1997. With 30,000 half hours of programming under its control, EM.TV has one of the largest children's and family entertainment businesses in the world. They also own or have major interests in a number of merchandising, television and animation companies throughout Europe and Australia. Their rapid growth has fueled one of the most impressive stock performances in European history. Since the company was listed on Frankfurt's Neuer Markt, the German version of Nasdaq, in October 1997, EM.TV's stock has risen from 34 DM per share to a recent price, on a split-adjusted basis, of about 11,300 DM per share. This represents an increase of 33,000 percent!
We have known EM.TV for several years, as one of our major European business partners, especially for the licensing of all our products in Germany. Like us, EM.TV is a family enterprise: Thomas and Florian Haffa are brothers who own a majority of their company. Needless to say, they are both huge fans of the Muppets.
What we saw in EM.TV, and in the Haffas, was exactly the international strategic, financial, marketing and distribution partner we have been looking for. What EM.TV saw in us were all the things that make The Jim Henson Company such a unique organization: you, our wonderfully talented and dedicated people, our host of Muppet characters, our hundreds of hours of programming, our consumer products business, our Muppet Workshop and Jim Henson's Creature Shop, and so much more.
What both we and EM.TV also saw-and see-is the tremendous potential of The Jim Henson Company as the growth platform for EM.TV in North America and the UK.
When the transaction is completed later this year, The Jim Henson Company will retain both our identity and our "personality." We will continue to produce television and film properties, develop and merchandise new characters, maintain our business relationships and pursue new business opportunities. And we will work closely with our partners at EM.TV to establish the combined enterprise as a major global player in the entertainment industry.
We want to emphasize that this transaction is driven by the growth opportunities it will create for EM.TV and for The Jim Henson Company. Neither we nor our new partners anticipate that there will be any jobs lost as a result of this transaction. For us, the primary significance of partnering with EM.TV is the benefits and opportunities it will create by making us an integral part of a very dynamic, very successful, highly growth-oriented global enterprise.
We also want you to know that the leadership of The Jim Henson Company will be substantially unchanged. Specifically, both of us will continue to be part of the Company. Upon completion of the transaction, Brian will continue to be responsible for initiating and driving the creative and technological forces of the Company as Chairman. Charlie will be promoted to President and Chief Executive Officer. Lisa Henson will be officially joining the Company as President of Jim Henson Pictures, and she will also serve as Vice-Chairman. We will work closely with Thomas Haffa and his brother Florian, who is EM.TV's Vice-Chairman and Chief Financial Officer. But we want to emphasize that creative decisions and day-to-day operational matters at The Jim Henson Company will continue to be handled by us. EM.TV has acquired several previously independent creative, production and other business groups in Europe, and their practice has always been to be "hands-off" owners, providing strategic, financial, marketing and administrative support, but leaving most creative, operational and financial decisions to local management. That will also be true with us.
We will be in London this afternoon, in New York at 8:30 local time Tuesday morning, and in Los Angeles at 4:30 local time Tuesday afternoon, to meet you face-to-face and answer your questions about this exciting new strategic relationship.
For now, we just want you to know that we think this is a great day in the long history of The Jim Henson Company-a day when we take the next, big step in establishing our Company as a global, growth platform, benefiting you, our business partners, our investors, and our millions of existing and future fans, throughout the world.
We will keep you posted on developments as we move toward completion, which requires customary regulatory and other approvals. For your information, attached is a copy of the press release issued this morning, announcing the transaction.
On behalf of the Company and the entire Henson family, we thank you for your contributions to our success, your continuing loyalty, and your support.


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Piano Man
Season 52 at South Coast Plaza has extended hours for its piano bar the New Year's holiday, featuring lead pianist Charlie Sleeth. Entertainment begins at noon, and again at 5:30 p.m. For more information, call (714) 437-5252.
Art Show
Orange County Fine Arts, an association of OC artists, presents an exhibition of artistic works by its members at the Showcase Gallery, South Coast Plaza Village, 3851 S. Bear St., Santa Ana. The gallery is open from 10:30 a.m. to 2 p.m. Wednesdays, 10:30 a.m. to 5:30 p.m. Thursdays, Fridays and Saturdays, and from 11:30 a.m. to 3 p.m. Sundays.
'Stuffed and Unstrung'
Henson Alternative presents "Stuffed and Unstrung," a comedy puppet show for adults, at the Irvine Barclay Theatre, 4242 Campus Drive, Irvine. For ticket information and showtimes, call (949) 854-4646 or go to http://www.thebarclay.org.
'White Christmas' Meal
In honor of the Broadway musical "White Christmas" at neighboring Segerstrom Hall at the Segerstrom Center for the Arts, Leatherby's Cafe Rouge is serving a special three-course "White Christmas" menu, with choices in each course. The cost is $39 or $54, with wine pairings. For more information, call (714) 429-7640.
Flashback Heart Attack
Flashback Heart Attack, an 1980s KROQ cover band, will perform at 9 p.m. at the Harp Inn, 130 E. 17th St., Costa Mesa. The show is 21 and older only and cover is $5. For more information, visit http://www.flashbackheartattack.com.
Book Signing
Hilary Malloy will sign copies of her children's book, "Skater Kate," from 11 a.m. to 1 p.m. at Martha's Bookstore, 308½ Marine Ave., Balboa Island.
New Year's Eve Celebration at Pretend City
The Pretend City Children's Museum, 29 Hubble, Irvine will host a New Year's Eve party for kids from 10 a.m. to noon. For more information, go to http://www.pretendcity.org.
Family New Year's Eve at OC Great Park
The Orange County Great Park will stage its inaugural Family New Year's Eve celebration from 5:30 to 9:30 p.m. As 9 p.m. approaches, there will be a countdown coinciding with the clock striking midnight on the East Coast. The Great Park balloon will descend as the ball in New York's Times Square drops. Admission is free but there is a $10-parking fee. For more information, go to http://www.ocgp.org.
Ring in 2012 at the Irvine Hilton
The Irvine Hilton, 18800 MacArthur Blvd., will put on its OC New Year's Eve 2012 bash from 7:30 p.m. to 1 a.m. For details and information about tickets, go to http://www.ocnewyearseve2012.com
New Year's Eve Block Party
The second annual New Year's Eve Block Party is from 7:30 p.m. to 1:30 a.m. at the OC Fair & Event Center, 88 Fair Drive, Costa Mesa, General admission tickets cost $40. For more information, go to http://www.ocfair.com.
New Year's Party for Singles
Kalida's New Year's Eve dinner and dance party, for singles between 29 and 49, will take place in the Tee Room at the Newport Beach Executive Golf Course, 3100 Irvine Ave., Newport Beach. The event is from 8 p.m. to midnight. No membership is required and the cost is $35. Call (714) 381-1223 for more information.
New Year's Eve at AnQi
AnQi by Crustacean at South Coast Plaza will put on a New Year's Eve celebration, starting at 9 p.m., with the "Forbidden Den" and featuring Q du Soleil and the new wave band Berlin, featuring Terri Nunn. Tickets cost $170. RSVP at firstname.lastname@example.com, or call (714) 557-5679.
New Year's Eve Gala at the BBC
The Balboa Bay Club & Resort, 1221 W. Coast Hwy., Newport Beach, will put on its New Year Eve Gala, from 8 p.m. to 1 a.m., among other New Year's Eve offerings. The black tie event will feature a live band and dancing. Cost is $195 per person. To make a reservation, go to http://www.balboabayclub.com or call (888) 445-7153.
Ring in the New Year Aboard a Yacht
The eighth annual New Year's Eve Yacht Party will take place in Newport Harbor aboard the 150-foot vessel The Majestic. If tickets for the party on the Majestic sell out, tickets will be sold for a New Year's Eve party aboard another yacht, The Ambassador. Tickets for the four-hour cruise through the harbor range between $145 and $170. For tickets, go to http://www.un4seenproductions.com or call (949) 378-9971. The event begins at 8:30 p.m. at 2901 W. Coast Hwy., Newport Beach.
New Year's Eve at Detroit Bar
KCRW presents Junkie XL, Jason Bentley and the Cosmic Kids at the Detroit Bar, 843 W. 19th St., Costa Mesa. The 21-and-older show begins at 8 p.m., with pre sale tickets for $25. For more information, visit http://www.detroitbar.com.
XL NYE, Day 2
Costa Mesa-based Sutra rings in the New Year in style with a special show, featuring the biggest names in electronic music. Tiësto, Porter Robinson and other acts perform on New Year's day at the Observatory, 3503 S. Harbor Blvd., Santa Ana. General admission and VIP tickets are available by call (949) 777-3010. For more information, visit http://www.sutraoc.com.


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Design agencies and related businesses have connections and the experience to choose the right sign company that fits the project. However, the average business owner might only seek the services of a sign company once or twice, making the decision more difficult and overwhelming.
Sign companies can specialize in design, installation, production, maintenance, and even the securing of permits. Some will offer all of the those services, while others might only offer a few.
Choosing the right sign company is best summed up by the following excerpt from the article How to Choose a Sign Company:
Shopping for a sign company is just like shopping for any other company. Look for signs you like and ask the business owners to tell you who built it for them. Look in a directory such as the Yellow Pages, or check out the various organizations referenced in this booklet.
It is a good idea to comparison shop, look at examples of signs the company has built and decide whether the company is capable of meeting your particular needs. Cost, quality, and follow-up service are obviously important considerations, as well as the variety of other services that may be included. For instance, securing a sign permit can be a challenge to the inexperienced small business owner; an experienced sign builder will handle this process more easily.
For more information on this and other topics related to signage 101, visit: https://www.signs.org/SignIndustry/Signage101/HowtoChooseaSignCompany.aspx


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Here's a post that I did for another blog earlier this year that I just happened to go back and look at. You never know, maybe this will get the rant-wheel rolling again…
What's the world coming to?!?
January 10, 2011
Granted, I could have been hallucinating (I have been known to take peyote, wash it down with gallons of "Incredible Hulks" and listen to Strawberry Alarm Clock and the Crazy World of Arthur Brown… on repeat), but I seem to recall some gun-wielding-nut job crashing a town hall-style meeting in front of a shopping center. When all was said and done, 6 people (including a Federal judge and a 9 year old girl) lost their lives and 14 others were injured. Sound familiar? I assume that, unless you live on a glacier, you know what I'm talking about.
Now that I've set the scene for you, take a look below at what I saw when I went to my Internet homepage this evening:
Now before you jump down my throat, I understand how things work. I know every story gets their five minutes of fame here, while thumbnails of previous stories are shown below. But a "Slinky-like 'Ark'" house? Really?!? Since when did shitty science fiction become more newsworthy than what happened in Tucson? Prepare to be delighted with a few verses from the slide show that accompanied this link:
"The foil is recyclable, self-cleaning, lighter, more durable and more economic than glass."
"…can be built to float on water, and can withstand rising tides and floods of biblical proportion."
"…can also be constructed in earthquake zones."
"The basement can store wind, thermal, and solar energy for up to six months, which can then turn into electricity."
So let me get this straight… the structure is God-proof? For those unfamiliar with one of the world's three major religions, God CREATED the world and then sent a flood to "shake the Etch-a-Sketch". Do you really think your buoyant, self-cleaning habitrail can compete with that? Ever seen Star Wars? The Death Star was destroyed by Luke piloting an X-wing with his targeting computer TURNED OFF! Do me a favor, don't tempt fate that way; I'd like to get married and start a family some day.
Why is this news?!? Is there even such a thing as "self-cleaning foil"? If it's anything like "self-cleaning" ovens, I'll pass. After all, I've seen self-cleaning ovens defeated by baked on spills from tater tot hotdish. I'll consider allowing you to make an announcement when you've got a working prototype but until then, back to the drawing board.
It's a shame we can't give events like what happened this past Saturday the time and respect they deserve. The engraving isn't even finished on the tombstones and we've already moved on to solving over-population by modeling shelters after toys created during World War II. Come on folks, it *is* too soon for "news" like this…
On a more positive note… it's nice to see Malcolm-Jamal Warner trending. I'm a huge Cosby Show fan.


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Jones, P (2013) Studying global education policy with ethnographic discourse analysis. In: 57th annual conference of the Comparative and International Education Society (CIES), 10 - 15 March 2013, Hilton Riverside Hotel, New Orleans, Louisiana.
Official URL: http://www.2013.cies.us/
|Item Type:
|Conference or Workshop Item (Paper)
|L Education > L Education (General)
|Institute for Education
|Date Deposited:
|14 Jul 2014 11:45
|Last Modified:
|14 Jul 2014 11:45
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"It gladdens me to know that Odin prepares for a feast. Soon I shall be drinking ale from curved horns. This hero that comes into Valhalla does not lament his death! I shall not enter Odin's hall with fear. There I shall wait for my sons to join me. And when they do, I will bask in their tales of triumph. The Aesir will welcome me! My death comes without apology! And I welcome the valkyries to summon me home!" – Ragnar Lodbrok
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