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Preheat oven to 350 degrees F. Butter a 9-inch pie pan.
Add graham cracker crumbs, cooled melted butter, and sugar in a bowl and mix well with a wooden spoon. Dump the mixture into the buttered 9-inch pie pan. Press the mixture into the bottom of the pan and continue pressing the along the sides of the pan. Make sure the crust is very firmly compact and even throughout. Bake for 8 minutes or until golden brown. Allow to cool and make the filling.
In a large stainless steel bowl, place egg yolks and sweetened condensed milk and whisk just to combined. While gently whisking to not add too much air, slowly pour in the key lime juice and add the zest and salt. Pour the mixture into the cooled crust. Bake for 12 minutes or until the filling looks set. This pie needs to set and firm up so allow to cool completely. Cover with plastic wrap and refrigerate overnight.
Cut the pie into 8 slices, placing 3 in the freezer for 1 hour or until firm (for the ice cream). The remaining 5 pieces of key lime pie can be kept in the refrigerator wrapped in plastic for up to 3 days - if they last that long!
Allow the vanilla to soften slightly on the counter. Remove the frozen slices of pie and cut them into 1-inch cubes. Return the pieces to the freezer; they can remain in the freezer well wrapped for up to 1 week.
Empty out the ice cream into a large stainless steel bowl, and add the pie pieces. Working quickly, use a wooden spoon to evenly incorporate the pieces into the ice cream. Cover and place in the freezer for 10 minutes.
To assemble each sandwich, run an ice cream scoop or tablespoon under hot water and scoop 1/4 of ice cream onto a graham cookie. Place another cookie on top and press down in the center being careful not to break it. Enjoy on a hot summer's day!
Sift the flour, whole-wheat flour, cocoa powder, baking powder, and salt. Add the nibs to the sifted flour and set aside.
Place the butter, brown sugar and granulated sugar in the bowl of a stand mixer fitted with a paddle attachment. Cream 3 to 4 minutes or until light and fluffy. Add the honey, molasses, vanilla paste, and egg, and cream for 1 minute.
With the mixer running on low speed, add the dry ingredients to the machine. Mix for 1 to 2 minutes or until the dough comes together. Be careful not to over mix. Place the dough directly onto a piece of parchment paper. With your hands, press the dough into a rectangle. Place a second sheet of parchment paper on top and roll out the dough into a 12 by 18-inch rectangle, 1/4-inch thick.
Flip the dough over and release the paper. Chill the dough for 20 to 30 minutes or until firm.
Meanwhile, preheat oven to 325 degrees F.
Place the cold dough on a work surface. Using a 3-inch round cookie cutter cut out 24 cookies. Place the cookies on a parchment-lined sheet pan leaving 1-inch between cookies. Using the flat end of wooden skewer make seven small holes in the cookie. Sprinkle with turbinado sugar. Place the cookies in the oven and bake for 16 to 18 minutes. Remove from the oven and allow to cool completely. The cookies can be made up to 3 days ahead of time. Store at room temperature in an airtight container.


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Classic Linksoul fit with subtle stripes and muted details, these polos will keep you covered while the evenings are still long enough for half-a-round or half-a-pint. Tucked-in and dressed up or thrown over board shorts, 100% cotton makes them cloud-soft and breathable for all-day, anywhere performance.
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Customize your product based on the available color options and decorating methods. If you need more information, simply add this product to the Wish List and we will get back to you with answers.

subset: commoncrawl


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Aloha. If you didn't notice, I was sort of gone for a couple of weeks.
Here are some images from my time away.
And of course, there were more photos, but I didn't edit or Instagram any of them.
Add a sista on Instagram: @maeluu
Wishing you joy, happiness and beauty.
Me ke aloha ~ With love, Xx
Comment on this post on My Facebook Page, join me and be my ohana (family)!
Be my homies! | Instagram: @maeluu | thereafterish. life & style blog RSS Feed | thereafterish. on Facebook | Lookbook.nu | Bloglovin' RSS | Xx.


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For those who care less about the process, and more about the end result
For those who care less about the process, and more about the end result
I put together some interviews with Podestrians on Thanksgiving because I had a guest with a very big personality Rikiesha. We had a good time, check it out:
Today is Avril's album release! We had a long day of setting up & shooting the press junket on the 48th floor of this beautttiffuuuulll hotel. We rented a 4bank & 2 Diva 400's from Adorama to light Avril. The interviewer was off camera except for FUSE who brought in their house and 2 cameras
After the last journalist (I lost count) it was time to get silly for Av TV before bedtime (Good Morning America tomorrow)
I am proud to have worked on such a beautiful song/collaboration for Christina & the Brooklyn based musicians A Great Big World. This is one of those "anything can happen" stories where an artist puts their heart into something and just let's it out into the universe. He is very fortunate to have Christina's support, but the simplicity of the melody and the honest lyrics is what got him there.
Christina sung it on The Voice with such heart:
After much statistical preparation, I have completed my pitch video for PodShare #2!
"Social Travel." It's a buzz word, sure, but it's also at the core of an exciting trend in the way people are interacting with one another across the country and around the globe. Companies like AirBnB (more than 10 million bookings since its launch in 2008), Lyft (more than 100,000 active users this year alone) and WeWork (16 co-working spaces in major cities across the country) have begun to clearly define niches in the peer-to-peer, social marketplace. But no company has brought the social travel concept to the overnight hospitality market. No company, that is, other than PodShare.
PodShare Hollywood, our first location, opened in February 2012 and has maintained profitable operations and an annual occupancy rate of 92% (the national average is 60%). This custom built, centrally located and affordable concept is staking a claim in the share economy.
Let's take our pods on the road like Lyft, into people's hearts like AirBnB and onto desks like WeWork.
If you are interested in joining our investment group, please email email@example.com
Well this is exciting! The production team at TV4 did a video story on me & PodShare. My goal was to keep it real so there you have it:
I shot 2 days worth of footage from Miley Cyrus' music video for WE CANT STOP and here are 2 snippets as teasers for her upcoming release:
My video contest entry for airhead bites
15 second spec spot – rhyme & use of my stock library
Big thanks to Morgan from Lezlympics for allowing me to shoot her competitive all girl event, and of course all of the other clips that were shot previously and recycled here. Joni shot me rhyming into the lens in our grassy front yard – with multiple interruptions from cars and dogs. We got what we needed though! Big thanks to Megan Ochoa for letting me use 15 seconds of her song.


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Timeless Cinema Tuesday
Oak Forest | Website
This event occurred in the past.
Map | Find Parking
"My mama always said, 'Life was like a box of chocolates. You never know what you're gonna get.'" Tom Hanks stars in this month's movie as the title role; while not intelligent, he has accidentally been present at many historic moments, but his true love, Jenny Curran, eludes him.


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A winning Lotto ticket worth more than £2.5 million bought in Northamptonshire has yet to be claimed.
The ticket, bought in the south Northamptonshire or Daventry area, matched all six numbers in the Lotto draw on February 7, 2015. The winning Lotto numbers on that date were 3, 6, 15, 17, 18, 35 and the bonus ball was 22.
The lucky ticket-holder, who has won a total of £2,598,424, only has until August 6, 2015 to claim their prize.
In a bid to try and publicise the prize winning ticket and encourage the winner to come forward, Northants Steelbacks stars will be facing giant 4ft-wide Lotto balls in the nets ahead of their upcoming T20 Steelbacks match against Durham Jets on Friday, July 24.


text: Terms of Use Privacy Policy Hide TOP 10 Top 10 Entertainment Top 10: Hot Mediterranean Women Share Tweet Flip 0 Shares 6. Jacqueline Kennedy Onassis While Jacqueline Kennedy Onassis may have been born in New York and rose to fame on the world stage while on the arm of JFK, she would later become synonymous with the Mediterranean after marrying Greek shipping tycoon Aristotle Onassis. She married Onassis in 1968 and from that point on became "Jackie O." She and her kids lived on a private island in the Ionian Sea and became models for a Mediterranean life of luxury. She's still a style icon today and the very picture of poise and elegance. Next Page TOP 10 9 8 7 6 5 4 3 2 1 Show comments Comments Share your opinion Your name Recommended Reading Top 10 Fitness 10 Home Exercise Products That Are Actually Worth Buying Top 10 Better Man 10 Awesome Ways to Drink Beer Top 10 Better Man Alcoholism Can Affect Anyone Top 10 Better Man A Definitive Ranking of Vodkas You Should Be Drinking


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Office photocopiers
No office can be considered complete with no photocopier. In fact, no office should do without a photocopier machine ready for use. Office photocopiers are so important that the possible lack of this specific resource can be a major flaw in a office system. The benefit of having they is because they practically work fast, nevertheless they get it done quite affordably as well. This is accomplished all due to its unique duplication technology that allows you to create duplicates of merely one document instantly and cheaply.
Multifunctional devices
Since office photocopiers do not use exactly the same printing technology as desktop printers, they don't eat the expensive ink used by printers, and often produce output at faster rates than normal printers plus larger quantities too. These are the basic factors that are the key reasons why office photocopiers have become an integral part of businesses.
Multifunctional devices
The goal of a photocopier shines in the event it does what it really does best, make copies. This can be done by manipulating good and bad charges that creates a power decal which determines what elements of a website will be printed on and just what remains blank. This process takes just a few moments and is repeated very easily. From creating enough copies of memos that have to be distributed to all employees in the entire building, to earning fliers being provided to lots of people, nothing makes copies faster than the usual photocopier machine. When making a large quantity of duplicates using a photocopier, an office can save considerable time, money and other valuable resources.
As mentioned before, photocopiers don't take in the same type of ink as printers do. Printers often make use of a powder based ink so that you can print, this is cheaper and can produce more copies than its equivalent in inkjet cartridges. Even though the effort to create an additional copy of a few pages might not be worth the trip from the working cubicle to the office photocopier, creating large volumes of duplicates about the photocopier as opposed to the printer will surely save a lot of money for the office.
Speed is one of the primary explanations why photocopiers are still widely used in offices today. As soon as that the original source is positioned about the scanning glass, making copies is just a couple of button presses away. You can have over hundred copies of the document within a few minutes with a few office photocopiers. This advantage is best sustained by features for example multiple feeding trays that automate the whole process of organizing pages together. Of course, office photocopiers won't staple or bind all pages automatically for you personally.
Office photocopiers also can function as process checkpoints at the office. As photocopiers frequently have multiple loading trays for queuing documents that span multiple pages, different personnel can collaborate on a single multi-page document by each utilizing the responsibility of making a certain page then later feeding it to be able to the machine. Office photocopiers can certainly take these separate documents, make duplicates and arrange them in precise order.
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Routine HIV Screening in France: Clinical Impact and Cost-Effectiveness
Yazdanpanah, Yazdan
Sloan, Caroline E.
Charlois-Ou, Cécile
Le Vu, Stéphane
Semaille, Caroline
Costagliola, Dominique
Pillonel, Josiane
Poullié, Anne-Isabelle
Scemama, Olivier
Deuffic-Burban, Sylvie
Paltiel, A. David
Published Versionhttps://doi.org/10.1371/journal.pone.0013132
MetadataShow full item record
CitationYazdanpanah, Yazdan, Caroline E. Sloan, Cécile Charlois-Ou, Stéphane Le Vu, Caroline Semaille, Dominique Costagliola, Josiane Pillonel, et al. 2010. Routine HIV Screening in France: Clinical Impact and Cost-Effectiveness. PLoS ONE 5(10): e13132.
AbstractBackground: In France, roughly 40,000 HIV-infected persons are unaware of their HIV infection. Although previous studies have evaluated the cost-effectiveness of routine HIV screening in the United States, differences in both the epidemiology of infection and HIV testing behaviors warrant a setting-specific analysis for France. Methods/Principal Findings: We estimated the life expectancy (LE), cost and cost-effectiveness of alternative HIV screening strategies in the French general population and high-risk sub-populations using a computer model of HIV detection and treatment, coupled with French national clinical and economic data. We compared risk-factor-based HIV testing ("current practice") to universal routine, voluntary HIV screening in adults aged 18–69. Screening frequencies ranged from once to annually. Input data included mean age (42 years), undiagnosed HIV prevalence (0.10%), annual HIV incidence (0.01%), test acceptance (79%), linkage to care (75%) and cost/test (€43). We performed sensitivity analyses on HIV prevalence and incidence, cost estimates, and the transmission benefits of ART. "Current practice" produced LEs of 242.82 quality-adjusted life months (QALM) among HIV-infected persons and 268.77 QALM in the general population. Adding a one-time HIV screen increased LE by 0.01 QALM in the general population and increased costs by €50/person, for a cost-effectiveness ratio (CER) of €57,400 per quality-adjusted life year (QALY). More frequent screening in the general population increased survival, costs and CERs. Among injection drug users (prevalence 6.17%; incidence 0.17%/year) and in French Guyana (prevalence 0.41%; incidence 0.35%/year), annual screening compared to every five years produced CERs of €51,200 and €46,500/QALY. Conclusions/Significance: One-time routine HIV screening in France improves survival compared to "current practice" and compares favorably to other screening interventions recommended in Western Europe. In higher-risk groups, more frequent screening is economically justifiable.
Other Sourceshttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956760/pdf/
Terms of UseThis article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4889579
- HMS Scholarly Articles [15718]
- SPH Scholarly Articles [4831]
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Sunday, August 21, 2011
Fairy Tale Vector Illustrations
I actually cannot believe I found this on one of my old hard drives. I am a bit of a digital pack rat... See if you can guess the stories in each image...
4 comments:
Your style works really well with vector. I'm surprised you haven't used it more as an alternative to your labor intensive paintings. (Says the man who slaves away at perfect likenesses when crude marker scribbles would have done nicely.)ReplyDelete
Anyways, these are as appealing as your paintings.
Maybe I don't know my fairy tales as well as I should.ReplyDelete
I'm stumped on the prince on the white horse and the queen on the throne.
Is the last image all devoted to Sinbad?
Not sure I completely agree with Brian. I see a lot of improvement from this to your recent work —particularly your handling of birds and animals.
The princess on a glass mountain is a variation on Cinderella according to the Sur La Lune website.ReplyDelete
It was a fun project and when I look at it now, there are definitely dome different decisions I would make in some of the images.
I am glad improvement is perceived. It is a constant journey so I hope I am not going backward yet :)


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> Wingate By Wyndham Houston Bush Intercontinental Airport IAH
Guest Reviews of Wingate By Wyndham Houston Bush Intercontinental Airport IAH
overall rating
out of 5
This Holiday Inn Express is very convenient to the Intercontinental Airport, Downtown Houston and Interstate 45. While driving directions generally have you take the Sam Houston Tollway, it is actually more convenient to take Beltway 8. The hotel is easier to find if you drive the Beltway. The complimentary continental breakfast was on par with what most hotels offer. The coffee was excellent! The room was very clean and with a comfortable side chair.
Friendly and helpful staff, room very nice, ceiling fan, great coffee.
No convenient restaurants (within 3 miles); at least two trys to flush the toilet.
overall rating
out of 5
Everything was in good standings as far as the hotel and staff was concerned.
The staff was curtious about changes and updates.
Nearby construction of another hotel, fouling the entry to this hotel.
overall rating
out of 5
One of the best hotel experiences I've had in years and at a very good price. The staff was consistently friendly, professional and helpful. Manager was also friendly-so much so I thought I might be in some alternative universe. Hotel and room was spotlessly clean. I hardly ever rave about hotels being a jaded business traveler, but this hotel really deserves some recognition. Free hot breakfast was good too.
Staff was the friendliest and most helpful I have experienced in some time. Hotel was also very clean and new. Excellent free hot breakfast.
No real problems, but a bit far from restaurants. If you don't have a car, the shuttle driver will take you to three of the closest restaurants.
Wingate By Wyndham Houston Bush Intercontinental Airport IAH
1330 N. Sam Houston Pkwy E , Houston, Texas
Guest Score:
based on
202 guest reviews
The pet-friendly Holiday Inn Express Suites North Beltway is three miles from the George Bush Intercontinental Airport and comprises 60 rooms equally suited to the business or pleasure traveler. The three-story hotel operates a courtesy airport shuttle. Other items included with the room rate are a hot breakfast buffet, high-speed Internet access, a copy of USA Today, local telephone calls, in-room tea and coffee and parking. Corporate offices close to the hotel include Exxon-Mobil, Hydril, Halliburton and Continental. Area landmarks and attractions include several golf courses, the Sam Houston Race Track, Cy-Fair Community College, Reliant Park, the Space Center, Houstons museum district, the George R. Brown Convention Center and shopping at Willowbrook Mall and The Galleria. The hotel has one meeting room available for business or social functions that can accommodate 50 guests.
Rooms from
Wingate By Wyndham Houston Bush Intercontinental Airport IAH Hotel Information
All the guestrooms and 21 suites have a work desk with high-speed Internet access, flat screen television with cable news and movie channels, pay-per-view movies, refrigerator, microwave oven, iron and ironing board, coffee and tea making facilities, two dual-line telephones with voicemail and speakerphone and a hairdryer. Connecting rooms, rollaway beds and cribs are available.
Amenities offered
This inn has an outdoor swimming pool, whirlpool and a fitness center that is open 24/7. The complimentary breakfast is the only meal served here. Restaurants nearby include a TGI Fridays, the Kettle Restaurant, Good Eats and Jimmy Gs Cajun seafood restaurant. The 24-hour front desk has safe deposit boxes and information on area events and attractions. Other amenities include a business center, mobile phone rentals, daily housekeeping, guest laundry, same-day dry cleaning service and ice and vending machines.
Pets allowed
Meeting/banquet facilities
24-hour front desk
Fitness centre
Non-smoking rooms
Airport shuttle
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Family rooms
Free parking
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Hot tub/jacuzzi
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Airport shuttle (free)
On-site parking
WiFi available in all areas
Does HotelsByCity recommend this hotel?
This is one of the better airport hotels that is immaculately clean and surprisingly quiet at night despite the loud air traffic heard outside the hotel. That is the opinion of several guests who have stayed at this Holiday Inn Express. Clients were impressed with the friendly and efficient service and the free continental breakfast which included several tasty hot dishes. Those who used the airport shuttle said it worked well and the hotel was well located just a short drive from downtown Houston.
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Brighton Holistics are pleased to offer you the 'Hopi Ear Candling / Thermo Auricular Therapy' Training Course from Brighton, Sussex.
|Hopi Ear Candling or Thermo Auricular Therapy
|This course is accredited by the Federation of Holistics Therapists (FHT).
|Payment Method:
|Payments can be made via PayPal, bank transfer or by calling the Brighton Holistics office on 01273 672 690. To book online, simply select an appropriate Available Start Date and click the add to basket button.
|Brighton Holistics
|Jon or Ryan
|This Hopi or Thermo Auricular Therapy training course taught at Brighton Holistics is comprehensive and practical. This course gives you a thorough introduction, insight and instruction into all the areas required to become a Hopi Ear Candling Practitioner. The course covers the history, techniques and applications that go to make up the Ear Candling process.
|Learners must be over the age of 18 and meet the pre-course pre-requisites, which are shown below.
|The course is run over one day starting at 10.30am and finishing around 4.30pm.
Hopi Ear Candling Course – More Details
This Hopi or Thermo Auricular Therapy training course taught at Brighton Holistics is comprehensive and practical. This course gives you a thorough introduction, insight and instruction into all the areas required to become a Hopi Ear Candling Practitioner. The course covers the history, techniques and applications that go to make up the Ear Candling process.
Hopi Ear Candling, or Thermo Auricular Therapy, is an ancient and completely natural therapy, which has been handed down to us through many civilisations, including the Greeks, Aztecs and Egyptians. However, it is from the Native American Hopi people that it has come to the Western world and into modern complementary and holistic therapies.
This now popular therapy was probably used in ancient times for cleansing, purifying and healing on a spiritual level, but today it is known for its more physical benefits in treating ear and sinus problems. The practice is safe, non-invasive and pleasant.
Each student is supplied with a pair of Biosun Hopi Ear Candles for use on the afternoon of the course for their practice session.
During the course we will cover the following topics:
- What is Hopi?
- How the Biosun candles work,
- Looking at other candles which are available,
- How to use the candles,
- Health and safety,
- Contraindications to Hopi,
- Anatomy and physiology revision,
- Facial massage movements,
- Hopi treatment routine.
Course information
Qualification gained:
Federation of Holistic Therapists (FHT) Diploma in Hopi / Thermo-Auricular Therapy.
Course accreditation:
This course is accredited by the Federation of Holistics Therapists (FHT). This course has been awarded 10 CPD points.
Course Pre-requisites:
The qualification gained from this course will only be accepted for professional practice and insurance if the learner holds the pre-requisites of a recognised accredited Level 3 or 4 Body / Sports / Swedish Massage / Aromatherapy / Reflexology / Beauty (level 3) qualification.
If you require any help or advice regarding your training please don't hesitate to call Brighton Holistics on 01273 672 690.
Class Size:
A maximum of four learners per class, this allows the tutor to monitor individuals progress and development. As training is given in small groups, learners will be required to bring a model for each day of the training course, for you to practice the treatment on. Learners do not practice treatments on each other as this reduces the learning time by half. The model would not be required until 1.15pm. Please see the booking terms and conditions for information.
Manuals & Certification:
Training manuals will be downloadable to each learner via their online learning portal. These manuals will be available to download for 60 days once your course has started. It will be the learner's responsibility to download and save the training manuals within this time. Manuals can be read on all devices. Certification for your course will be emailed to you once you have met the learning outcomes.
Learning Outcomes & Evidence of achievement:
Learners will be required to show achievement of a range of relevant learning outcomes and assessment criteria, as set by the National Occupational Standard and Accrediting Body by:
- Practical assessments and theoretical knowledge will be assessed during your training time.
- Federation of Holistic Therapists (FHT) members will need to complete six case studies; this is made up of two clients each having three treatments. If you chose not to complete case studies a CPD certificate will be issued for this course and not a Diploma certificate.
Dates, Bookings and Information:
All available dates are shown above. To book your course, simply click the add to cart button shown next to the appropriate date or telephone Brighton Holistics on 01273 672 690.
If you have any questions regarding the Diploma and CPD courses we offer here at Brighton Holistics please telephone Brighton Holistics on 01273 672 690.
For information on the difference between a Diploma and CPD Course please click here for further information.
We've had many wonderful students and it's been our pleasure to assist them in attaining their educational goals. Read just some of their testimonials here.


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Just remember, it's fear. They are afraid of really finding out. Satan is a good red herring. I think we were all there at some point, on some level. I really do feel for TBM's. I'm also jealous of TBM's having the belief I once had. At the same time, I'm enjoying life much more. Sigh...
In which I lose my best friend
This is for encouragement, ideas, and support for people going through a faith transition no matter where you hope to end up. This is also the place to laugh, cry, and love together.
Post Reply
Re: In which I lose my best friend
Re: In which I lose my best friend
This really hurts big time, and this is one of the biggest reasons, for me being on this forum board, in the first place. To break any one of the Ten Commandments, is something that people may help others, to recover/repent from, but to go against the Church ( the religion), is akin to "Denying the Holy Spirit". This is very hard to grasp, why people are doing this, instead of helping one another, unconditionally(to a greater point). With the history of the Salt Lake(Utah area), being as bad as it was, you would think that the area is ripe for ghost hunting. Member shunning, has been a big problem of the Jehovah's Witnesses also. THIS IS A BIG OUCH.
Re: In which I lose my best friend
My best friend of 33 years and his wife decided to up and move to Missouri last year. They claim they were promted to. Who am I to question what they believe? They tried to convince my wife and I to move out there also but when I finally explained how I no longer believe in the church they cut off all ties. 33 years and they let the church get between us. I was sad for a week but moved on. Oh well. Have fun in your New Jerusalem, Garden of Eden.
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text:
Children's Foot Problems
Foot Structure Problems
Flat feet
Heel pain
High arched feet
Forefoot Problems
Hammer toes
Stress fractures
Nail Problems
Ingrown Toe Nails
Toe Nail Fungus
Prevention of toe nail fungus
Fungal toe nail treatment options
Steps to prevent reinfection of your nails
Thick Toe Nails
Skin Problems in the Foot
Athlete's Feet
Corns and Callus
Foot Warts
Sport Injuries Caused by Foot Instability
Achilles tendinopathy
Ankle Sprains
Ilio tibial Band Friction Syndrome
Patellofemoral pain syndrome
Shin splints
Systemic Foot Problems
Arthritis in the Foot
Systemic complications
Foot complications
Diabetes foot care DOs and DON'Ts
Peripheral Vascular Disease
Spastic and Paralytic Muscle Conditions Affecting the Foot
How can I determine if I am getting a custom made foot orthotic device
What steps are required to formulate a prescription for a foot orthotic
Frequently Asked Questions about Custom Foot Orthotics
Ankle foot orthosis (AFO)
How to get the best fitting shoe!
How to determine if your running or walking shoe needs to be replaced?
How to determine the right running shoe for you?
Checklist for the running shoe store
Evaluating the stability of a running shoe
Running mechanics versus arch height of the foot
Video Gait Analysis
Metascan Pressure Mat
Manual Therapy
Laser Therapy
Children's Foot Problems
Foot Structure Problems
Forefoot Problems
Nail Problems
Skin Problems in the Foot
Sport Injuries Caused by Foot Instability
Achilles tendinopathy
Ankle Sprains
Ilio tibial Band Friction Syndrome
Patellofemoral pain syndrome
Shin splints
Systemic Foot Problems
Shin splints
Shin splints are common among runners, race walkers and individuals who participate in soccer, football, lacrosse and dance. Shin splints are a non specific diagnosis for lower leg pain. One common cause of shin splints is periostitis. Periostitis is an inflammation of the periosteum. The periosteum is a dense connective tissue covering the shin bone or tibia. Periostitis results from an overuse injury that usually develops gradually over a period of weeks to months. Periostitis can also occur after one excessive bout of exercise. The periosteum serves as an attachment site for the muscles originating on the tibia. Muscle overuse causes the periosteum to pull away from the tibia causing inflammation.
Periostitis of the tibia has also been classified as medial tibial stress syndrome. Medial tibial stress syndrome is associated with an overuse of the anterior and posterior tibial muscles. Both of these lower leg muscles have attachments via tendons to the foot bones. The origin of these two muscles is where you will complain of pain. The locations of pain are the lower inside half of the tibia and, less commonly, the upper outside portion of the tibia.
You will usually notice the pain when you start exercising and it decreases or goes away as you continue to exercise. Your pain maybe worse after you stop exercising or it will bother you the next morning.
The pain from periostitis of the tibialis posterior muscle is located on the lower inside half of the tibia. Abnormal foot and lower leg alignment can cause excessive flattening of the foot that requires excessive work from the posterior tibial muscle to help stabilize the arch. This stress causes microtears and inflammation in the periosteum attached to the lower inside half of the tibia. Custom foot orthotics along with proper running shoes are quite successful in treating posterior tibial muscle periostitis due faulty foot mechanics.
Pain from periostitis of the anterior tibial muscle is located on the upper outside portion of the tibia. Anterior shin splints often occur in both legs. Anterior shin splints is caused from over-training or improper training, especially, if your running program includes a lot of excessive downhill running or a sport requiring rapid starts and stops.
You may also have an imbalance between the weaker anterior muscle group and the larger and stronger posterior group. Tightness of the calf muscles may further aggravate this condition. These stresses result in microtears and inflammation in the periosteum attached to the upper outside portion of the tibia. Successful treatment includes modified rest with changes in your training program. Physical therapy to address muscle weakness, tightness and imbalance is paramount. Foot orthotics will be indicated if abnormal foot mechanics are the cause of the muscle tightness or imbalance.
In some cases of periostitis there can be a progression to micro-fractures or stress fractures along the tibia. Generally there is not a sudden break of the bone but usually you will complain of a gradual increase in pain until it becomes quite severe.
There are a number other causes of lower leg pain that can mimic periostitis. They include: tendonitis, a partial muscle tear, growth plate inflammation, referred lower back pain, lower leg muscle imbalance, a leg length difference and compartment syndrome.
Compartment syndrome can occur in muscles originating from the tibia. Muscles are surrounded by fascia which allows for a separation between adjacent muscles. This fascia does not stretch. Pressure within the muscles can increase due to activity. The fascia does not allow the pressure to diminish. This can lead to muscle damage and pain.
If you have shin splints a proper diagnosis via a thorough history and physical exam is essential to rule out causes other than periostitis.
Treatment of Shin Splints
Conservative treatment for periosteal injuries usually consists of rest, ice, immobilization, compression and elevation, physical therapy, foot orthotics and footwear.
Rest or major modified activity
You need to dramatically reduce the frequency, intensity and time of your activity/exercise. This means you need to reduce the duration of your activity/exercise between 50 to 90 percent and doubling or tripling the time between your workouts. You can pursue cross training or try a different type of exercise such as swimming.
You cannot make the mistake of taking a few weeks off from you normal routine and then going right back to the same schedule without a reduction in training. If your activity is not modified your pain will return and it may become worse.
This is extremely useful for reducing the inflammation following a workout. You can apply ice for 10 to 15 minutes over the painful area as this will both decrease pain and increase healing time.
In some instances, if the pain in your legs does not respond to foot orthoses and physical therapy modalities immobilization will be required. Immobilization is accomplished with a removable or walking cast/boot or a non-removable fiberglass cast. The length of time of immobilization can vary between two to six weeks.
Compression bandages using Coban™ or Elastoplast™ taping prior to or following an athletic event or workout may be extremely beneficial. You can try a shin splint wraps such as a neoprene sleeve. Compression can help reduce recovery time.
Leg Elevation
Elevation of your lower extremities above your heart can help to reduce the flow of blood to the legs and will help to reduce the inflammatory process. This can help to reduce pain and healing time.
Non Steroidal anti-inflammatory drugs
Oral drugs such as Ibuprofen or Naprosyn are very useful for reducing pain and inflammation during the acute stages. However, one the down side anti-inflammatory drugs do have the potential to cause stomach irritation, ulcers or kidney problems. Therefore, you should limit the use of these medications to the acute phase of the injury.
Deep tissue massage
Deep tissue massage is useful technique for treating shin splints. You may be advised to seek deep tissue massage from a qualified physical or massage therapist. Deep tissue massage will be able to break down and smooth out knots in muscles or tight areas within the muscle. This will help reduce pain and prevent recurrence.
Custom foot orthotics
The stabilization of any abnormal foot and lower leg alignment is crucial. If this goes unaddressed, you will continue to experience a recurrence of periostitis. Custom foot orthotics will address help address the underlying cause of posterior or anterior shin splints.
Your choice of footwear is also important since different running shoes and cleats/turf shoes have different degrees of support and motion control. After about 450 miles running shoes typically lose 30 to 40 percent of the shock absorbing capabilities. The tread may look fine but the capacity to prevent injury is reduced. Uneven wear patterns from one shoe compared to the other may also be an indication of abnormal motion in one leg. (Please refer to "How to check to see if your running shoe needs to be replaced")
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Giles, I think this is a great idea and would like to participate in the development of the ontology(ies) around data protection. Regards, Alan Ross email@example.com -----Original Message----- From: Giles Hogben [mailto:email@example.com] Sent: Monday, April 29, 2002 9:00 AM To: Rigo Wenning; Brian McBride; Lorrie Cranor; firstname.lastname@example.com Cc: Stephen Kenny Subject: P3P rdf Hi, I am thinking of working up a draft of a formal DAML/OIL ontology for data protection. This is as a preliminary to a meeting between various data commissioners and European DG's to discuss a European Standard for P3P policies based on the Art 29 WG recommendations (probably an APPEL ruleset + guidelines + example policies + validator initially) on May 27th. I am considering this (translated into as plain English as possible) as the starting point for the discussion as it should ease the translation between Data Protection Directive language and XML/P3P. Another good reason for doing this is that I think we don't really have a formal ontology for Data Protection, and this would be an important prerequisite for any future versions of P3P + other AI type applications around data protection. Initially I am using a tool called "Oiled". Any comments on this - am I barking up the wrong tree? Is there an existing version of this already? Or is it in fact a good idea? Thanks Giles _____________________________________________ Giles Hogben TP361 CyberSecurity Unit Institute for the Protection and Security of the Citizen (IPSC) European Commission - Euratom Centro Comune di Ricerca Via Enrico Fermi 1 21020 Ispra, Italy Tel.: +39 0332 789187 Fax.: +39 0332 789576 e-mail: firstname.lastname@example.com <mailto:email@example.com>Received on Monday, 29 April 2002 13:11:40 UTC
This archive was generated by hypermail 2.3.1 : Wednesday, 7 January 2015 15:07:40 UTC


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Warsaw, Prague, Budapest, Bucharest, Bratislava, Belgrade, 5 October 2015 – International advisory company JLL presents its preliminary summary of investment transactions concluded in Q1-Q3 period of 2015 on the commercial real estate markets across Central and Eastern Europe (CEE).

The summer months have again seen a hive of activity across the CEE with a preliminary transaction volume of well over €2.8 billion recorded in the third quarter. This quarterly figure represents one of the strongest third quarters in the market's history and is only marginally short of the record breaking year of 2007. This activity brings the preliminary year-to-date regional investment volume to more than €5.5 billion and represents a 22% growth year on year.

Kevin Turpin, Head of Research CEE at JLL<\/strong>, commented: "With the final quarter of the year often representing one of the busiest periods for our investment teams, and looking at the pipeline of deals that are in advanced stages, we predict that the CEE regional volume could reach the €8 billion mark by the year end. Should the latter happen, it would put 2015 at the highest level since the economic downturn and third highest in the past 12 years".

The Czech Republic currently leads in terms of investment volumes with a share of 43% followed by Poland with 28%, Romania with 11%, Hungary with 10%, Slovakia with 2% and the SEE countries recording improved activity with a 6% share.

The breakdown of preliminary volumes for Q1-Q3 2015 is as follows:<\/strong>
Country               Q1-Q3 2015 Volumes* (€ millions)
Czech Republic    2,390
Poland                 1,550
Romania                 600
Hungary                 520
Slovakia                  105
Other CEE               340
Source: JLL, October 2015 (*Preliminary data)

Our view on prime office yields (Prague and Warsaw) are at between 5.75 - 6.00%. Retail yields for best in class products are at 5.00 – 5.25% and truly prime warehouse asset yields are expected at 6.50 – 6.75%. <\/p>


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8 Days in California. They have been INCREDIBLE. The beach, the people, the food, the yoga… LOVED IT ALL. My favorite eatery was Tender Greens… right in the heart of Santa Monica. The food was seriously… out of this world. The service, the vibe… everything about it screamed… California. The simple messages posted on the wall as you wait in line are inspirational. I liked this one among others. This is what I will carry with us as we begin the road trip back to Colorado today. ENJOY DOING NOTHING! O.K… I will.
*** Please visit Taozi Tree Yoga on Facebook for more on Taozi's travels, inspiration, and yoga pictures!***


text: Billboard offers full coverage of breaking music news and music chart toppers to music executives and fans alike. Billboard is the best print and online music magazine for in-depth music business news and access to an array of digital music, business tools and music videos. Search music news articles about your favorite artist or research evolving trends in digital music. Review Top 100 music charts to discover new songs, or download hot real music ringtones. Music executives can also review lists of RIAA-certified music. Also check out our music widgets and music trivia sections and keep coming back to discover new music, read exclusive interviews and watch hot new music videos from chart-topping artists. Visit Billboard.com each day to see what new song releases made it to No. 1 on the music charts.


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Wolf's Lair Abyss was the first 'major' piece of new studio material to be released by Mayhem after the murder of Euronymous by fellow artisan of extremity Varg Vikernes, and thus it's no surprise that it is welcome with only a bittersweet reception. There exists a faction of the black metal underground which likely rues the continued output of this franchise, just as there would be with any act whose celebrity core had its candle snuffed out. Imagine INXS without Michael Hutchence. Or The Doors without Jim Morrison. Oh, wait, they both actually did that. So is it really a surprise that Mayhem would plow forward, and was it the right decision? The only one, in my estimation, who could answer that, would be Euronymous himself.
But regardless of where emotions run on this matter, Wolf's Lair Abyss exists. The band has never ceased the churning of its creative gears, as few and far between as their studio outings might have seemed for a while. This EP happened, and so did the three ensuing full-lengths that have arrived between the late 90s and today. So it's got to be judged on its merits alone, rather than on some subversive vengeance for the fallen who may or may not be aggrieved as to its actual contents and presentation. Some of the other core personalities remain in the rhythm section. Bassist Necrobutcher returned for this, and Hellhammer stayed in his drum seat. Mayhem introduced the young Rune Eriksen to the fold, who would remain through the release of Ordo Ad Chao in 2007. From a technical view, I'd say he does a decent job here, perhaps a more intensified version of the very style Euronymous was producing. His acquisition feels seamless.
Perhaps the bigger surprise here was that the band reconnected with Maniac, who had provided some sick ass vocals on the band's legendary Deathcrush EP. He sounds as wretched as ever, even though I did not necessarily find the harried, blasting pace of these tracks as good a match to his suffocating rasp as the slower, earlier material. On some tunes, though, like the "Fall of Seraphs", both his gnarled and cleaner tones prevail. And did I mention the blasting? Because one of the most prominent characteristics of Wolf's Lair Abyss is just how much Hellhammer beats the everliving fuck out of his drum set. Seriously, his snare, bass and cymbals all tried to appeal to the local Union for their mistreatment, but there was sadly no clause for inanimate objects. That they're dialed up in the mix is one thing, but the sheer punishment this guy is meting out on "I Am Thy Labyrinth" and "Fall of Seraphs" is admittedly intimidating.
Unfortunately, as fresh and violent as this music is, which feels like a steady flow of bitter effluvia after a stubborn stretch of creative constipation, it's not all that memorable. The bass is loud and atrocious, the vocals injected with the heroin heights of Maniac's personality, and it's appreciably 'extreme' enough to outpace even it's full-length predecessor. But aside from its belligerent, beatdown sheen, I did not exact much from its content. The noise/ambient intro "The Vortex Void of Inhumanity" with its horns and vocal samples was an interesting experiment, but not really conducive to the ensuing eruption of "I Am Thy Labyrinth". Almost all the riffs here seem rather predictable and uninspired, merely projected along the same course as the drumming.
There are some thrashing breaks in the material ("Fall of Seraphs"), and a few psychedelic, haunting streams of notation ("Symbols of Bloodswords"), but all in all, I've always felt like I was listening to an eerie vocal trip, a drumming tour de force, and not much else aside from guitars which feel functional at best. So, as explosive a proclamation as Wolf's Lair Abyss might seem upon initial contact, it's simply not enduring as their earlier works, nor as experimentally curious as their later full-length efforts like Grand Declaration of War. A rush of night, surely, but not one I could ever remember after the inevitable morning crash.
Verdict: Indifference [6.75/10] (the order of the cosmic immoral)


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Can you do us a little biography to go in the book? And did you want a dedication?
So says the email. The biography is no bother: I will take the usual bee-keeping-and-yoga-thrice-weekly route beloved of the committed CV-writer (ie resort to fiction). The dedication involves a fraction more angst. Tim Dowling was memorable enough on the point back in June for me to go hunting for his article (worth reading in full, for the copy ed's rather sweet accidental rendering): A dedication remains…the first thing the reader sees after the title. As an author, one wants it to be reflective of the contents, or at least reassuring and inviting. The perfect dedication would also be immediately moving, or funny, or both; timely but also timeless. No pressure, then.
My first book was dedicated to my nephews and nieces (all doted upon to an embarrassing degree, given that they are now aged from 19 to 13 and, really, doting bookish auntienerds are not the ultimate teenage accessory). Since then, I've acquired a new niece. Clearly she deserves a dedication so she can catch up (and because she is AWESOME) – but, then, is it unfair to give her a whole book all to herself, when the others had to share? What about my sisters, who have nurtured this book along far more than the last? And my parents, who have throughout, and with extraordinary restraint, refrained from gently suggesting I should get a proper job? Then there are the friends, the editors, the virtual folks who've contributed just by being online. I am Halle Berry, and I would like to thank my lawyers.
I think I've decided what I would like to do. (Probably.) And I wrote the book, so it's sort of up to me. But, you know, actually it's dedicated to YOU, yes YOU, no, really, YOU THAT'S READING THIS RIGHT NOW, YOU SPECIAL LITTLE PUPPY. And that bloke next to you. Him too. And his nan. So if you should feel a mite neglected by the dedication, you are a silly, because PUPPY YOU is totally included within it really.
Too many emails. Nice emails about festive shopping and unicorns, as well as the tedious work ones, but still: lots.
See above. Plus I'm playing Name That Character! which is always a bit of a laugh. (I called someone Tallulah once because it took a while to type, and thus gave me time to think what came next. Expect Biscuits & Lies' cast list to contain Geldof-esque levels of absurdity.)
Pretending that Monday and Tuesday are still the weekend, faffing in London, watching old Wire in the Blood, eating crumpets.


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Unravel centuries of Hong Kong's history on a tour that takes you from the bustling harbor to its historic villages and a local family home. Enjoy trips on several forms of transportation as you explore the iconic landmarks and hidden boroughs of the popular contemporary city.
After you're picked up from your hotel, your tour takes you to the water for a journey on one of Hong Kong's icons, the Star Ferry. Hop on the historic form of transportation and cruise through the harbor, past the sights of Hong Kong's skyline. After you return to dock, board a double-decker tram—one of a handful of modern tram systems in the world—for a rapid ride through the city.
When you disembark from the vehicle, head to a studio practicing the traditional custom of Da Siu Yan. Watch experts undertake the voodoo-like practice known as "villain hitting," and get the chance to try it out for yourself.
Next, explore the nearby fishing village of Shau Kei Wan. Wander through the traditional enclave, walking to an open-air bazaar and through colorful stalls that display fresh and exotic fruits, herbs, and vegetables.
Follow your guide through Main Street East, a historical area where pirates once hid, on your way to the Ming Wah Dai Ha public housing estate. You can meet a local family that lives in the incredible 9-story structure and learn how to play mahjong, one of Hongkongers' most popular pastimes, before you return to your hotel.


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Professional Poker Tour Selects Veteran Poker Pro and Hollywood Personality as Hosts17 May 2006
OS ANGELES, California -- (PRESS RELEASE) -- With Mike Sexton and Vince Van Patten, the WORLD POKER TOUR (WPT) captured lightning in a bottle. The chemistry between these two personalities — one veteran poker pro and one Hollywood personality with a passion for poker — has been a major factor in the Travel Channel show's success. Now WPT Enterprises, Inc. creator of the WPT, is looking to use the same formula to help ignite its newest venture, the Professional Poker Tour (PPT), slated to debut on the same network Wednesday, July 5 at 9 p.m. ET/PT.
Leading poker pro, WPT Finalist and two-time World Series of Poker bracelet winner Mark Seif joins personable actor and poker aficionado Matt Corboy behind the mic for commentary on the exciting new series, that will feature a host of new innovations in televised poker.
The action-packed PPT series will showcase poker's 250 leading stars in a new and exciting format, destined to ratchet up televised poker to a whole new level. The PPT will bring to TV viewers the cream of the crop -- 250 of the world's top poker players, culled from thousands who aspire to the first rank. With its PPT Qualification System, the PROFESSIONAL POKER TOUR has ensured the highest level of play at each and every tournament. The first season of jam-packed action will stretch over 24 weeks, spotlighting a stellar lineup of poker's All-Stars – champions from the WPT, The World Series of Poker, and European poker tournaments.
"We think poker fans will love the interplay between these two commentators," said Steve Lipscomb, CEO and founder of WPT Enterprises. "Mark's strategic insight combined with Matt's magnetic personality provide for great entertainment and an easy way to pick up pointers on improving one's game. Analyzing the differing styles and the psychological warfare between poker's leading stars will give them plenty to work with."
Here's a look at the two PPT hosts:
Mark Seif
As the commentator, Mark Seif comes to his position with a bona fide poker championship background. He won two World Series of Poker bracelets in 2005: the $1,500 buy-in No-Limit Hold'em for $611,145 and the $1,500 Limit Hold'em Shootout for $181,330—the only player to win dual bracelets last year.
Seif was a well respected and well–paid lawyer who quit law to play professional poker. And while this talented prosecutor did well at the bar, he has truly made his mark—and his bankroll—at the poker table. Playing professionally for the past five years, he has won well over two million dollars.
His numerous other tournament victories and Final Table finishes includes a collection of titles: the Bicycle Casino's Legends of Poker, the World Poker Open (Tunica), World Poker Finals (Foxwoods), Borgata Open, Festa al Lago (Bellagio) and Sport of Kings (Hollywood Park). In 2003, he was ranked 12th in CardPlayer Magazine's Player-of-the-Year standings.
Even though it is the first time that Seif will serve as a host for the PPT, he is no stranger to the WPT, having scored a fourth place, $38,700-victory in the WORLD POKER TOUR's inaugural stop at the Bicycle Casino. He currently has winnings of $104,853 on the WPT, having been in the money on four occasions
A poker player since he was six, Seif showed such a natural inclination that his father barred him from the family poker games at 10, when he won a particularly large pot. He did not play again until he was 19, while working as a waiter during college. One of his fellow restaurant workers staged a home game and then it was a toss up for Seif—hit the cards or the books!
The books won out—at least for the time being. Seif attended UCLA and graduated with high honors in 1991 with a degree in Economics. He then went on to Loyola Law School in Los Angeles and graduated in the top 10 percent of his class in 1997, receiving numerous American Jurisprudence Awards (among them honors for achieving the highest grade in his class). While in law school, he clerked for the Los Angeles District Attorney's Office, prosecuting more than 200 felony preliminary hearings and trials under a special program that let law students perform as prosecutors under the direction of other more experienced attorneys. The most high profile case to which he contributed was the O.J. Simpson trial.
He left the DA's office to join a Newport Beach firm -- Fisher & Phillips, a national law firm specializing in employment and labor law. Subsequently, he was appointed Chief Counsel of America's biggest leasing company in 2000 and moved to Lake Tahoe, NV, where he began commuting to Las Vegas and Los Angeles each weekend to play poker. That continued even after he left that prestigious position to become a professional poker player in May 2001. In 2004 Seif, who now lives in Las Vegas, was picked to do commentary for the PPT.
For fun, Seif indulges his interest in saltwater reef aquariums and entertains his new baby daughter.
Matt Corboy
Most poker players learn to "act" by perfecting their bluffing skills. Matt Corboy learned to play quality poker by virtue of his acting skills. Corboy was tutored in Texas Hold 'em by Jennifer Harman and Scotty Nyugen while filming the poker movie, The Big Blind, in 1999, in which he played Jennifer's brother. The actor/TV-show-host has now parlayed his interest in the game and his telegenic personality into a roll as one of the two hosts for WPT Enterprises' Professional Poker Tour.
As a teenager, Corboy and his friends would gather at his grandparent's house in Honolulu, Hawaii every Wednesday night to play poker. That lasted until he went off to college at Colorado State University in Fort Collins, CO. Though he graduated with a business degree, Corboy decided to pass up that world to give acting a try first.
Since 1996, he has built a successful career, acting in films, TV, commercials and as a host for television or web-based shows. Most notable, was his three-year stint as the villainous police officer Ray Carlson on The Shield. He's also had guest roles on The West Wing, Cold Case, The Loop, Threshold, JAG, Malcolm in the Middle and Spin City. Additionally,he is a regular at the Los Angeles Improv Olympic, doing improvisational comedy. When not in front of an audience or camera, Corboy plays poker whenever he can find a good home game in Los Angeles.
An avid player who watches each of the WPT episodes multiple times to pick up playing tips, Corboy admits that doing the color commentary on the PPT and watching the professionals has substantially elevated his own game.
Corboy surfs, mountain bikes and competes in triathlons in his spare time. He's also personally doing the renovation of his house, while enjoying being the father of a newborn.
About WPTE
WPT Enterprises, Inc. is a company engaged in the creation of internationally branded entertainment and consumer products driven by the development, production, and marketing of televised programming based on gaming themes.


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Fr. John Parker
Fr. John Parker is rector of Holy Ascension Orthodox Church in Mount Pleasant, South Carolina. Fr John earned his MDiv at Trinity Episcopal School for Ministry in Ambridge, PA. After serving for a brief period as curate at Holy Cross Episcopal Church on Sullivan's Island, SC, He and Matushka Jeanette, along with their two sons, embraced the Orthodox Faith in 2002. Fr John earned his MTh at St Vladimir's Orthodox Theological Seminary in Crestwood, NY, in 2004. In October 2011, he was appointed Chair of the Department of Evangelization of the Orthodox Church in America.


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Kate Sherrod blogs in prose! Absolutely partial opinions on films, books, television, comics and games that catch my attention. May be timely and current, may not. Ware spoilers.
Wednesday, November 27, 2013
J.R. Rain's SILENT ECHO
Silent Echo is probably going to be marketed as mystery or crime fiction; I gather the other, J.R. Rain, is somewhat an established name in those genres, at any rate, and there is a mystery plot forming the novel's narrative backbone, but really, the mystery is the least interesting thing about the book.
The private eye tracking the killer - who turns out to be something of a serial killer, with signatures and weird motivations and the will to play games with the people trying to catch him and all -- is dying, you see. Of AIDS-related lung cancer. And it's not just a someday sort of dying; as the novel opens, Jimmy Booker has already lived two months beyond his prognosis, and is struggling every day to do basic things like get out of bed. Fortunately -- and this is where Silent Echo really stands out -- he has an amazing, selfless, generous and wise friend to help him through everything.
Numi, a Nigerian artist who has transplanted himself to Los Angeles and met Jimmy many years ago while Jimmy was investigating a case, skirts the "magical negro" trope for the most part, though he has moments. What saves him from just being one is the degree to which he has devoted himself to keeping his friend Jimmy alive; he's not a guru, not an impassive dispenser of wisdom, nor is he merely a helpmeet, though he is that as well. He is a kind and loving friend, who lets Jimmy occasionally act like a selfish jerk, calls him on it only very gently, helps Jimmy with even the most intimate of tasks, and has become the benevolent dictator governing who, in Jimmy's last days, gets to bother him.
A childhood friend of Jimmy's makes the cut, and that's where the murder mystery comes in; Jimmy's specialty is missing persons, and Eddie's wife (a sort of unlit old flame of Jimmy's as well) is missing, under circumstances that echo the missing persons case that started it all for Jimmy back when he was a teenager: the disappearance and murder of Jimmy's kid brother.
The plot, in other words, is dead simple, even a tad predictable, even given the twist of this being the detective's last ever case and one he can't investigate without an extraordinary amount of help. But this book is not to be read for the plot, it's to be read for the relationships, for the honesty and regret and bitterness and extraordinary (platonic) love and the chillingly plausible descriptions of what it feels like to be facing the very end of life, how a person's outlook and priorities change and how one real friend can make all the difference.
Quite a nice little read.
Posted by Kate Sherrod at 10:50 PM
Labels: crime fiction, death, friendship, mystery
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+966 12 676 0000 Ext.2403, 2405, 5557
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As fun as splashing around in the tub can be for your little one, bath-time offers so much more than just playtime. At Johnson's, we're strong believers that even the most basic of everyday rituals can offer new opportunities for your child to learn.
Inspired by all those special moments you share together as you wash out paint stains; detangle messy knots; and scrub away at those little nooks and crannies, we came up with our own formula that's safe to use on your little one every day. Housed in a bottle rich with honey and nigella extract, we hand-selected these ingredients for their unique skincare and germ protection benefits and kept our product true to its name: Johnson's Pure Protect Kids Bath & Wash range.
In the spirit of making the most out of your tub adventures, we put together some of our favorite ideas for educational games and activities below that are sure to make bath-time a memorable experience for both you and your squeaky clean companion.
Explore bath books
Who says story-time happens only after the pajamas are on? Bath books are a great way for kids to learn to make connections between their own lives and the world they see in pictures. Teach them new words and encourage them to sound out the letters on their own. Stories that rhyme or feature new songs can be especially engaging. By bringing books into the bathtub, your child will learn to love reading—anyplace, anytime.
Put on a bath-time puppet show
Interactive games, like bath-time puppet shows, can help boost your child's social and communication skills. Make or buy your own specially-made bath-time puppets and have them put on a show for you. Responding with laughter, cheer, or excitement will help boost their confidence and inspire their imagination. To help encourage your little one's creativity, get involved with a back-and-forth dialogue. Roleplaying will teach your child to improvise and help develop valuable decision-making skills.
Create art with bath crayons
Bath crayons are another way to inspire your child's creativity. Bring out their inner artist with these simple coloring tools that offer them the opportunity to draw on a canvas that is as big as their imaginations are wild. And don't be afraid of letting them make a vibrant mess—just a few wipes will get the bathtub walls and tiles clean in no time.
Have fun with bubbles
That's right—you can even turn a simple bubble bath into a learning experiment. Fill up spray bottles with water dyed in food coloring and watch as your child learns to identify different colors by spray-painting the bubbles. If your little ones are old enough to grasp the concept of mixing colors, see if they can guess what color change will happen with each new color added.
Go fishing!
Challenge your kid's motor skills and hand-eye coordination with a fun game of fishing! Fill the bathtub with magnet letters, numbers, and a few sea-life creatures like fish, crab, and seashells. Tie a magnet to the end of a fishing pole and encourage your child to catch the numbers or letters in chronological order. If your child is a bit younger, test their skills by seeing how many they can catch at once. For added fun, a few drops of food coloring will turn the water blue.


text: Nancy's two Xolos service dogs are a truly unique. Both are highly trained and intelligent animals that can understand many commands. Because of the uniqueness of the breed and the animals lack of hair, their body heat helps Nancy deal with the chronic pain. Though Nancy still occasionally struggles with her pain Pink and Toaster are always there to the rescue. For the full article click here.


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Friday, August 20, 2010
Week 1 COMPLETE!
After the mask is fitted, a frame is placed over the mask. This frame sets 'markers', so they can be sure the radiation is reaching it's intended target. Each day, Matt receives 2 quick X-rays to make certain nothing has shifted. Then, he receives his therapy. In Matt's case, there are 7 different beams of radiation. Each beam delivers 3 minutes of radiation. Therefore Matt spends approximately 21 minutes each day in the radiation machine.
Since we are not allowed to be in the room or even watch the monitor while he gets his radiation, we can only guess what exactly happens. I do know that there is a large 'arm' above him on the machine that can rotate and also the 'bed' Matt is lying on can rotate slightly in 6 different directions. I'm sure it's not quite as intense as a simulation ride at Disney World, but that's what it reminds me of when they explain it!
Matt was thrilled with the way his mask turned out - and so were we! It has sort of a graffiti look to it with the words 'Cancer Sucks' written across it in red. If you know our family, you know that we don't usually speak like that, or allow our children to speak like that. BUT, given the circumstances, it seemed appropriate! :)
On Tuesday, we had all the boys with us. We had Will go in with us so he could see the machine and get a sense of what Matt was doing each day.
On Wednesday, we met up with a friend that Matt met at 'Camp Hobe'. Truly, an amazing camp! Anyhow, Matt and this boy were in the same cabin and hit it off. They are the same age and he also has a brain tumor, slightly different pathology, but with most of the same symptoms that Matt has. I cannot tell you how refreshing and therapeutic it is to spend time talking with another mom who totally and completely 'gets it'. I don't have to explain ANYTHING to her. We have the same daily challenges, the same long-term concerns, and similar personalities when it comes to advocating for our kids. It was great!
The logistics of radiation are proving a bit tricky, but doable. School started this week for my older boys. Warren has those 3 here at home. Since they are gone from about 8:30 to 4:00, it allows Warren to get a full work day in. Starting next Monday, I've hired a girl who just graduated from college to come every day when the boys get out of school. She will help them get a snack, do their homework, and practice piano. Matt and I are staying in Layton with Warren's mother. She has been gracious enough to welcome us and is proving extremely helpful in every way! We've scheduled radiation for 2:00 in the afternoon with the hope that we can put Jake and Audrey down for naps and they can stay with Carolyn while Matt and I run to his appointment. It's about 2 hours door to door, so it's perfect for a nap time for my littlest ones. This week went off without a hitch. Matt's school has also been very accommodating. We went in and spoke to them last week. They have a home-bound teacher who will be collecting all of Matt's work and acting as a go-between for the school and Matt. Since he should feel fine through radiation, he should be able to do his homework. He's a kid who thrives on school and schoolwork, so hopefully this will just be a blip in his school career.
Thanks for thinking of us and checking in on us! We're just plugging along at this! It feels a little bit like eating an elephant, but we're slowly taking bites and are 1/6 of the way done! :)
11 comments:
I'm sure you must tire of hearing how strong and positive you are being and that everything will be ok, when what you'd really like to do is shake your fist at the universe and scream at the top of your lungs! Well, I too am strangely comforted by your posts and amazed at your courage. I've said it before, but I'll say it again-- Matt stole my heart a long time ago and to see him smiling throughout his ordeal just makes my affection for him grow stronger! He is an amazing young man with an amazing family. You're all Rock Stars in my book!
- Kristen said...
You. Amaze. Me! Matt's attitude really shows through in your pictures. Although, I have never met him, I can tell he is one great kid! And why wouldn't he be with the parents he has as examples! Good luck with your journey. I'm not sure I could be so strong!
- Cheryl @ On the Old Path said...
Hi Allison,
I followed your link to your blog from the PBT group. You have a beautiful family. Matt is such a brave boy. Blessings to you and your whole family.
- Katie said...
Wow. I'm glad things are going so well. Sounds like you have a pretty slick plan! I'm glad the school has been so accommodating. How fun to have lunch with such a good friend! We are keeping you in our prayers!
- Jessie said...
Wow. I'm glad all the logistics are working, and that you have connections closer to SLC. If you're ever in a pinch, my house is always open to any of you!
- LeishaMaw said...
Good luck and prayers your way.
- The Uffens Family said...
mmm... elephant! (although I'm sure it's one of those things you'd rather eat just once!!) : )
- courtney said...
hi :)
i've been meaning to check in with yo forever! but please know that your family is ALWAYS in my heart & prayers.
i was so sorry to read that matt's tumor has grown, but inspired by your post of your gratitude to live in a day with good medical care. you truly inspire me!
i hope matt is handling the radiation well, i know the Lord and his angels are with your entire family.
lots & lots of love to you. i wish i could give you big, big hug.
love, courtney :)
- Ker-Dog and the gang said...
the cancer sucks mask is perfect :o)
I hope the radiation kills it once and for all! Glad you have help with working out the logistics of with all the kids! You guys are definitely rock stars!
- courtney said...
hi :)
i don't have your e-mail & i've been thinking of you lately. just wanted to send you my love, our prayers are always with you!
love, courtney
if you get a minute email me your address please:
- Huish Family said...
Love that mask! We always told the kids we don't "hate"... yet cancer and hate quickly went hand in hand. Sadie was quick to remind us we don't say that, but we told her it was OK to hate her tumor and cancer... she seemed happy with that!
I regret to say I had to play catch up a bit with the blog - I am so sorry for the news of growth. Matt's a tough kid, and he will do great. You are in good hands at Huntsman, and of course Primarys. We are here if you need us in any way.
Love, The Huish's


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With the massive influx of Arab and foreign tourists to the cities of Morocco this summer as well as the return for vacation by Moroccans living abraod, the local prostitution market has shown signs of recovery as prices have gone up. According to Elaph website, it is a difficult task nowadays to find in a Casablanca nightclub a "good looking female candidate" to spend the night.
In the face of the growing demand, prostitutes increased their prices. In order to spend one night with a local prostitute, a man will have to pay from 500 dirhams (about 70 dollars) to over 1500 dirhams (about 170 dollars), the website reported.
An Elaph reporter in Morocco spoke with one of the prostitutes and asked her about the price for the night. The girl answered him: "If you have a place to spend the night, I will charge you 1000 dirhams (about 120 dollars), but if you do not have a place, you are asked to provide additional 400 dirhams (about 60 dollars), so I can hire an apartment from one of my friends. "
Sadly, for many young females in Morocco, prostitution is the "easy" way to earn money. Thus, the north African kingdom has a significant rate of prostitution. However, the authorities are trying to fight this industry from time to time. Since the beginning of 2009, there were hundreds of arrests of prostitutes in Morocco, according to local press reports.
© 2000 - 2019 Al Bawaba (www.albawaba.com)


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Ignacio Cortez
Highlands High North Highlands, CA Class of 1991
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All month long, you are able to find great inspiration and technique tutorials on the My Creative Scrapbook blog shared with you by their fabulous DT and GDT.
Today it is my turn to share with you some tricks of the trade. Here is once again the Limited Edition kit that I was sent to play with this month:
You can see all the gorgeous MCS kits by clicking HERE.
My #1 embellishment to use on any crafty project is flowers! There can never be enough flowers on any layout or card I create. The April Limited Edition kit is full of gorgeous blooms and I was able to make more by using already available flowers and modifying them a little. Here are a few tricks on how i created a few flowers off my layouts.
I wanted a big pink flower to pop out of my B'Day Girls layout. I took the big Prima bloom, some gesso, embossing paste as well as mists and inks and went to work on it.
I started by covering it with gesso,
followed by embossing paste,
and then a mixture of different Glimmer Mists shades.
To achieve the color I wanted, I decided to add some Distress ink. I then sprayed on some more Glimmer Mists until I got the desired shade.
I then decided to do the same for the center of another bloom to match the first one.
These flowers can be found on my B'Day Girls layout shared with you earlier this month:
Keep checking in all day for more tutorials!


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Though Suzie and Dov met near New York City and got engaged in the mountains in upstate New York two years later, the couple decided to tie the knot in October of 2014 in Washington, D.C. "We chose the Willard Hotel for its Old World charm, as well as how close it is to all of the major D.C. landmarks," Suzie explains.
And while planning a wedding can be hectic and stressful, it was anything but for Suzie and Dov. The pair hired Jeannette Tavares of EVOKE, and Suzie called upon her experience as a six-time maid of honor to figure out the details, then let Jeannette take the reins. "Helping my friends plan their weddings taught me to let go and enjoy the ride as much as possible," says the bride.
So how did that laid-back attitude work out? Flawlessly. Keep reading to see the couple's traditional Persian ceremony and timeless ballroom reception, photographed by Dominique Fierro.
Photo: [Dominique Fierro](http://www.dominiquefierro.com)
The couple's classic theme started with ivory invitations, topped with the bride and groom's monogram.
Photo: [Dominique Fierro](http://www.dominiquefierro.com)
In keeping with the blush color scheme, Suzie selected a pink trumpet gown with a hand-tufted skirt by Monique Lhuillier — and she picked it all by herself. "I shopped with some friends, but when it came to picking my dress, I made the final decision alone. Going to the salon one last time alone helped me think clearly," she explains.
She paired her gown with Jimmy Choo peep-toe pumps, a romantic half-up hairdo, and a bouquet of white calla lilies.
Photo: [Dominique Fierro](http://www.dominiquefierro.com)
Dov looked handsome in a custom tuxedo, which he paired with a watch that was gifted to him by Suzie's parents. To fight the October chill, Suzie slipped a blush faux-fur wrap around her shoulders.
Photo: [Dominique Fierro](http://www.dominiquefierro.com)
The ceremony took place in the Willard Room, with rows of Lucite chairs on either side of a candlelit aisle. The traditional sofreh aghd was decorated in coordinating colors, and featured family heirlooms and lush roses and hydrangeas amongst the traditional fresh fruits, nuts, and sweets.
Photo: [Dominique Fierro](http://www.dominiquefierro.com)
In the ballroom, cream fabric was draped from the ceiling around the hotel's chandeliers, and a plethora of candles lit arrangements of cream and blush roses, hydrangeas, and calla lilies. "The first time we saw the ballroom, we were blown away by how beautifully everything had come together," says Suzie.
Photo: [Dominique Fierro](http://www.dominiquefierro.com)
"We mixed different chargers, linens, and floral arrangements to keep the event feeling traditional while still giving it a contemporary twist," says the bride. For dinner, the couple served an extravagant buffet, including Shirin Polo, a traditional sweet Persian rice that is served to symbolize the sweetness of marriage.
Photo: [Dominique Fierro](http://www.dominiquefierro.com)
A DJ, accompanied by a saxophonist, cellist, and percussionist, got everyone on the dance floor, beginning with Dov and Suzie's first dance to "Marry Me" by Train. The couple cut into a cream cake decorated with fresh garden roses and gold dots.
Dov and Suzie headed south for their honeymoon, stopping in Rio, Buzios, and Floripa in Brazil. Says Suzie of their wedding, "Don't stress over the little details. You won't even notice them in the end!"
Ceremony & Reception Venue: The Willard Hotel || Wedding Planner: EVOKE || Bride's Wedding Dress: Monique Lhuillier || Shoes: Jimmy Choo || Jewelry: Chanel || Hair: Bridal Hair by Remona || Makeup: Carl Ray || Groom's Attire: Enzo Sartori || Wedding Bands: Tiffany & Co. || Florist: Edge Flowers || Invitations & Paper Goods: Sincerely Yours, Emily Baird || Music: Exclusively Entertainment || Catering & Cake: The Willard Hotel || Rentals: DC Rentals, Party Rental Ltd., La Tavola Fine Linen || Lighting: John Farr Lighting || Favors: Le Chocolatier || Sofreh Aghd: Sofreh Atelier || Photography: Dominique Fierro
For more local wedding vendor listings, go here!
Did you love this classic wedding? Then check out another traditional bash in the video below!


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The primary goal of the central carolina amphibian and reptile initiative (CCARI) is to help implement the mission of parterns in amphibian and reptile conservstion(PARC) at the local level.The PARC mission is to conserve amphibians,reptiles and their habitats as integral parts of our ecosysem and culture through proactive and coordinated public/private partnerships.
1. Increase public awareness and involvement in the conservation of amphibians and reptiles and their associated habitats.
2. Develop partnerships and increase communication and cooperation among all persons and groups interested or involved in herpetofaunal research and conservation within the central Carolina region.
3. Share data from regional studies with the national PARC database.
4. For the central Carolina region: Determine and map current and historical amphibian and reptile diversity and distribution. Determine current species status, species distribution, and relative abundance and habitat requirements.
5. Act as a central Carolina regional resource for herpetological information while endeavoring to insure the protection of sensitive species and habitat data.


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For the video for their song "Tharsis Sleeps," metal band Throne turned to an unlikely format—they created the first frame-by-frame embroidered music video. Each shot is comprised of many individual knitted squares made by computerized embroidery machines. The video was directed by Nicos Livesy, who is also the singer and guitarist for Throne, and possibly part of the most hardcore sewing circle around. Below you'll find the video along with a few shots of the painstaking process to assemble this whole endeavor. (Via Geekologie)
THRONE - 'THARSIS SLEEPS' (OFFICIAL VIDEO) from Nicos Livesey on Vimeo.


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Hard for some to imagine that there could be similarities between Christian Louboutin's shoes and Rick Owens style, right?
^Reference: Pringle of Scotland dress and Club Monaco python belt
Well at least with CL's Woodstock finish, the heavily distressed leather reminds me of RO's Blister Biker jackets in that both are somewhere between suede and grained leather. The leather has been pulled to a point where it's become "fluffy" but not yet as velvety as suede, which I think is just a delicacy on its own! I love the feel! Woodstock is available in Bianca, Numéro Privé, and New Déclic. Please welcome my new shoe addition to my CL collection,
New Déclic 120 in PK7H Nude Earth Woodstock Calf Leather
So I do have to admit that I'm not so much into CL anymore. I've been put off by the highly jacked up prices for really simple designs and the hype that drives this craze is just… CRAZY for a lack of better wording. It reminds me of the reasons for why I left Louis Vuitton. A luxury brand should NOT be (relatively) mass-produced to the point where there are more than 2 dozen styles per season just for the purpose of profit, resulting in quality control issues that have surfaced most prominently this season.
Anyhow, these New Déclics fit about the same as the old Declics, which other people have said to run smaller by half size and the newer version are more TTS. I honestly don't feel much of a difference. I fit into the same shoe size 36 as the older ones. I also prefer the older CL styles now for their comfort since the newer shoes are going into insane heel heights of 150+ which are not practical for me. The New Déclics are very comfortable with a hidden platform. The toe box is spacious allowing you room to wiggle your toes, but length-wise runs half size small as I've already mentioned.
Since the leather is suede-like, I would treat them the same as suede: Meltonian to the rescue!!! 🙂


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Most of us make use of computer systems in our life. Whether we are researching for a level, getting in touch with close friends, sending a work application or seeing a video clip online, the web could be something that we truly depend on.
Some individuals suggest that, regardless of the numerous methods which they make our lives simpler, there are however numerous drawbacks to computer systems and also the net.
Why not comprise your very own mind by reviewing our checklist of 10 benefits as well as negative aspects of computer system and also net?
Exactly what is a computer system? And also just what is the web?
A computer system is, etymologically talking, anything that makes computations. It has actually been said that the abacus is a primitive type of computer system. In the modern-day feeling, however, words 'computer system' is most typically utilized to describe a digital tool which could send out as well as get information, and also procedure that information to make sure that it is purposeful to human beings!
Numerous computer systems are linked to the net in the existing day. The web is a worldwide network of interconnected computer systems, which enables these computer systems to share info with each various other.
10 Benefits of Computer systems as well as the Web.
1. Saving information.
The disk drives on computer systems, and also the online storage space centers online (such as cloud based storage space systems) allow us to keep significant quantities of information, securely and also safely. All those priceless vacation pictures, which unique you have actually been keying away at, will certainly all be maintained forever for you to gain access to whenever you require them.
2. Remaining in touch.
The net is a terrific method to remain in touch. Utilize an e-mail, social media sites, or video clip conversation solution to connect quickly with individuals around the globe.
3. Remaining educated.
All the globe's understanding (well, a lot of it) comes through the web. All it takes is a couple of clicks and also you might be reviewing anything from the holy places of old India as well as China to the look for formulas for settling the circle.
4. Necessary for research study.
Increasingly more colleges– and also increasingly more institutions, as well– are requiring that trainees research, review their essays, and also send their job making use of computer systems as well as the net.
5. Release your creative thinking.
Paint programs as well as songs modifying software application are simply 2 of the manner ins which computer system software application could improve your creative thinking. A growing number of musicians are integrating electronic elements right into their job– with spectacular outcomes.
6. Sharing your suggestions.
Beginning a video clip blog site, or a composed blog site, as well as you could share your ideas, concepts, and also research study with individuals throughout the globe. Accumulate a follower base in nations that you have actually never ever checked out as well as come to be a net experience!
7. Remaining educated.
The net information is currently upgraded faster compared to published papers are. If individuals desire to obtain up to the min info concerning existing occasions, the web is the location to go.
8. Unwinding.
Utilize your computer system to see a DVD or stream a video clip, to pay attention to a podcast or listen to your favored radio program. There are a lot of chances for remainder and also leisure below.
9. Accelerating computations.
The very first computer systems, made by Charles Babbage as well as Ada Lovelace were made use of to do intricate estimations at a portion of the rate that it takes people to do them. Computer systems are really useful for modeling challenging design formulas– or simply for totting up your allocate the month in advance.
10. Remaining arranged.
An entered record, a convenient documents, and also a cool spread sheet: every one of these computer system based devices are fantastic for maintaining your life arranged!


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Conservative activist reportedly threatens to steer donors away from RNC over taxes
A prominent conservative activist and fundraiser is reportedly threatening to steer donors away from the Republican Party if GOP lawmakers agree to raise taxes.
Brent Bozell, founder and president of conservative watchdog group Media Research Center, sent a letter to Republican National Committee (RNC) Chairman Reince Priebus on Wednesday promising to advise conservative donors to shun the party if its leaders in Congress sign a deal to raise taxes, The Hill reports.
Bozell — who is also the chairman of ForAmerica Inc., a Virginia-based nonprofit — has been active in conservative political circles for three decades and estimated he has raised hundreds of millions of dollars for a litany conservative causes.
"Reince, it pains me to say this, but if the Republican Party breaks its word to the American people and goes along with President Obama with tax increases, it will have betrayed conservatives for the final time," Bozell wrote. "I will make it my mission to ensure that every conservative donor to the Republican Party that I have worked with for the last three decades — and there are many and they have given tens of millions to Republican causes — gives not one penny more to the Republican Party or any member of Congress that votes for tax increases."
A spokesman for the RNC did not respond to a request for comment, The Hill reports.
Separately, Bozell also sent letters to House Speaker John Boehner and Senate Republican Leader Mitch McConnell earlier in the week, pushing them to reject Obama's call to raise taxes on the wealthy.
"With the so-called 'fiscal cliff' rapidly approaching, both sides are making opening gambits and the talk so far is alarming," Bozell wrote in a letter dated Tuesday to Republican leaders.


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* * *
Over the last few days, I was also able to squeeze in The Porcine Canticles by David Lee. What an amazing ear! I also read Andrei Codrescu's Jealous Witness. I will certainly be revisiting these collections over the next few days.
* * *
I also learned that I completely suck at Madden '09 (XBox). My horrible performances with the Chargers' musta put a jinx on their ass or something.


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For me, that doesn't mean I'm leaning toward optimism so much as it means I might have put the foot back down that was extended over the ledge.
The four-game winning streak the Stars are on now is kind of weird. It's hard to believe. Not that it's not possible, it's just weird.
The game against the Carolina Hurricanes was fairly definitive. I haven't been following the Hurricanes that closely, but I think it was a legitimate win. The Stars played well. They didn't back into the win at all.
The game was very entertaining. Lots of back and forth, lots of almosts, lots of bouncing pucks and cool defensive plays. Ribeiro and Daley were all over the ice. I thought Ribs had a pretty good game.
Right before Neal scored in the first, the 'Canes tried many times to clear the puck and the Stars kept keeping it in. Woywitka caught the puck at the point as it ran around the glass to keep it in. Neal scored soon after that. Not only were the Stars keeping the puck in the 'Canes' zone, they also kept the 'Canes out of their own zone.
They were responsible and aggressive. The forwards helped the defense and the defense played well. And Kari did a fine job of not messing any of it up. Usually he is covering for people but this time he didn't have to too much.


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Good morning bloggers,
I had to make a card last night simply for the therapeutic benefits. My youngest son is 4 and a half, had the biggest tantrum he's ever had in the middle of my local shopping centre yesterday. It was the kind of tantrum when all mothers look at you with complete sympathy but at the same time think 'thank God that's not my child.' In fact, when one man saw I was struggling he told me I 'would get my reward in heaven.' Actually, I got my reward yesterday evening in the form of a huge glass of wine....swiftly followed by another...
Anyway, in my quest for therapy involving less alcohol I had a play with Cindy's lovely sketch over at Freshly Made Sketches:
I'm really enjoying using 6x6 paper pads at the moment...it takes the guesswork out of matching papers and just makes the whole process that much quicker. I've used an MME one for this card, together with a balloon die from Fancy That. Loved the sketch and I'm sure it's one I'll go back to again.
Have a great day and thanks for popping by!
Claire x
Sunday, 23 June 2013
Freshly Made #91
3 comments:
gorgeous Claire... like you i am loving 6 x 6 pads at the moment they re so great xxReplyDelete
Claire, this is simply fantastic! I love the lovely details and that balloon is wonderful! Glad you joined us this week at FMS!ReplyDelete
Love the paper piecing and the mix of dsp. It sounds like you definitely deserved some therapeutic stamping time. I hope today is better. Thanks for joining us at Freshly Made Sketches this week!ReplyDelete
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Osteosarcoma (OS) is one of the most common primary bone cancers and often occurs in either young people in their 10s and 20s or elderly adults in their 60s and 70s. Our understanding of the genetic factors critical for OS formation and metastasis is still limited. Lack of understanding for the genetic pathways of those factors impedes the progress of developing effective therapeutic strategies to treat this malignant disease. The p53 gene, which is mutated in more than 50% of human tumors, has been reported in sporadic OS. Recently, our and other studies suggest that activation of Notch signaling contributes to the pathogenesis of human OS and its inhibition may be a therapeutic approach for the treatment of OS. Notch signaling plays an important role in developmental processes and adult tissue homeostasis by regulating cell fate determination, proliferation, differentiation and apoptosis. Altered Notch signaling has been associated with several cancers and can act both as an oncogene and tumor suppressor gene depending on its expression levels and timing. In this project, we propose to study the genetic interaction between the Notch signaling and p53 pathways in the development of bone tumors. This will address an important interface between stress-generated p53 pathway and skeletal developmental pathway of Notch signaling in the pathogenesis of OS. By applying both Notch gain and loss of function models in vivo, we will determine its requirement and genetic interaction with p53 in formation of OS. Success of this proposal will have an important positive impact on clinical application, because it will identify a genetic role of Notch signaling in development of OS. The proposed Specific Aims provide direction in identifying a crosstalk of Notch signaling and p53 pathways for initiation and/or progression of OS. In addition, these studies will provide the genetic mechanistic frameworks of how Notch signaling and p53 interact in the context of bone cells. Eventually, understanding of those genetic pathways and their interaction will lead to and facilitate the development of novel approaches for therapies in humans.
Understanding how the genetic factors and pathways function in tumorigenesis have broad implications for health and disease. Specifically, we will understand how those factors interact in the formation and spread of bone tumors. The overall goal of this project is to translate findings to consequential therapies for bone disease.
|Tao, Jianning; Jiang, Ming-Ming; Jiang, Lichun et al. (2014) Notch activation as a driver of osteogenic sarcoma. Cancer Cell 26:390-401
|Chen, Shan; Tao, Jianning; Bae, Yangjin et al. (2013) Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression of Sox9. J Bone Miner Res 28:649-59
|Tao, Jianning; Koster, Maranke I; Harrison, Wilbur et al. (2012) A spontaneous Fatp4/Scl27a4 splice site mutation in a new murine model for congenital ichthyosis. PLoS One 7:e50634
|Bae, Yangjin; Yang, Tao; Zeng, Huan-Chang et al. (2012) miRNA-34c regulates Notch signaling during bone development. Hum Mol Genet 21:2991-3000