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Desalination Process or desalinization is a procedure that expels minerals from saline water. All the more by and large, desalination may likewise allude to the evacuation of salts and minerals, as in soil desalination, which likewise happens to be a noteworthy issue for agrarian generation.
Desalination Process
Salt water is desalinated to deliver crisp water suitable for human utilization or watering system. One potential by-result of desalination is salt. Desalination is utilized on numerous seagoing ships and submarines. The greater part of the current enthusiasm for desalination is centered around creating financially savvy methods for giving crisp water to human use. Alongside reused wastewater, this is one of only a handful few precipitation free water sources.
Because of moderately high vitality utilization, the expenses of desalinating ocean water are for the most part higher than the choices (crisp water from waterways or groundwater, water reusing and water protection), yet choices are not generally accessible and fast overdraw and exhaustion of stores is a basic issue around the world. Furthermore, there is an ecological expense. Citing Christopher Gasson of Global Water Intelligence, "right now, around 1% of the world's populace are subject to desalinated water to meet their every day needs, bu the desalination business has an exceptionally solid future to be sure."
Desalination/refining is one of humanity's most punctual types of water treatment, and it is still a prevalent treatment arrangement all through the world today. In antiquated times, numerous civic establishments utilized this procedure on their boats to change over ocean water into drinking water. Today, desalination plants are utilized to change over ocean water to drinking water on boats and in numerous bone-dry locales of the world, and to treat water in different ranges that is fouled by common and unnatural contaminants. Refining is maybe the one water treatment innovation that most totally decreases the greatest scope of drinking water


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|RPG Gag Comic
"Wait. What is Parting Shots?" You ask.
If you do submit, give yourself the best chance by including your name and address. Kenzer and Co.'s submission guidelines are here, which indeed need an update, but I can confirm that after an inquiry with one of the editors, that Parting Shots is now included under paid content. Follow the guidelines. I can only offer advice as a fellow submitter... AKA, in an unofficial capacity, but you have questions just ask. Good luck! (and mind my, inside joke: (Egg Embry)

subset: commoncrawl


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Catalogue for a travelling exhibition of the artist project Weather Report, initiated by Rienke Enghardt.
The exhibition travelled from Leiden to Bankok, Yangon, Kuala Lumpur, Jakarta, Yogyakarta, Hanoi, Ho Chi Minh City, Chongqing, Beijing, Singapore, Hong Kong and Groningen.
Together with Rienke and Nardy Stolker I travelled from Thailand to Myanmar and Malaysia in September and October in 1995.
This is the first time OT Versa (Nardy) has been used in print.
228 x 228 mm
60 pages
4 color, cover 2 colors
Typeface: Nardy (OT Versa) and FF Sheriff.


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THE BOOK OF MORMON's Jason Michael Snow Set for The Duplex's Monthly 'DINNER PARTY' Tonight, 9/17
Tonight, September 17, 2012, The Duplex will serve up the delightful monthly musical soiree We're Having A Dinner Party: A Jubilee of Delicious Music. The Book of Mormon's Jason Michael Snow will serve as Dinner Party's special guest for the September installment where he will make various appearances throughout the evening.
"It's a party! Hosted by Babs Rubenstein and Liam Forde, indulge your palate with a smorgasbord of music. Rubenstein and Forde serve up a different menu of songs every month, and their diametric talents offer two contrasting palates for two diverse appetites." Forde was most recently seen in Amazing Grace with Goodspeed Musicals and Rubenstein was featured in the Cleveland staging of the new musical Fat Camp last summer.
In addition to Snow, joining Rubenstein and Forde onstage are Kristen da Costa and Corbitt Williams. The musicians include accompanist Rona Riddiqui, and drummer Zach Eldrige. Musical Direction, arrangements, and additional material are by Forde, and direction is by Joe Barros.
The Duplex is located at 61 Christopher Street in NYC. Doors open at 9pm, and show time is 9:30pm. Tickets are $10 in advance and $12 at the door, in addition to a 2 drink minimum. To order tickets in advance visit: www.theduplex.com or call 212-255-5438.


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is there any information at all regarding to casting time relation with INT stats?
is there a certain INT breakpoints to achieve etc.?
would be great if anyone can share. even better if GM can confirm or help on the information.
Users browsing this forum: No registered users and 1 guest


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Supervisory Board
Hajo Wagner
Chairman of the supervisory board of BESTAR Stahlhandelsgesellschaft Remscheid mbH
Since April 1, 1981, Hans-Joachim (Hajo) Wagner had been the leading head of BESTAR in Remscheid. The native of Holzminden came to Velbert in 1952 as a five-year-old with his family from Lower Saxony. He studied business management after his apprenticeship as an industrial salesman. Through his sporting activities in ping pong, he came to journalism in a side job and made numerous contacts. He decided to become politically active and took over the presidency of his party in 1977 and committed himself to politics at local and regional levels until 2009.
The year 1981 brought a big change professionally for Hajo Wagner. Until then, he worked as sales manager for a local industrial radiator company. He did not miss the chance to steer a company himself, and on April 1, 1981 he took over the position as Managing Director of BESTAR Stahlhandelsgesellschaft Remscheid mbH, which at that time had just 5 employees and had sales of 1.8 million Deutschmark (about 900,000 Euros).
At first BESTAR, founded in 1978, was to ensure the supply of the local sawmill and knife industry. But under his leadership BESTAR quickly developed into a supraregional steel service center. Hajo Wagner's commitment and reliability are also the hallmarks of BESTAR today. BESTAR is not just a steel trading company. On the contrary, BESTAR focuses on the individual needs of its customers and their products. Be it through customer-oriented stock storage, order planning, special dimensions or even the development of special steel grades.
BESTAR supplies customers all over the world. From Australia and New Zealand to Asia, Europe and the Americas, BESTAR is the contact person for steel for manufacturers of industrial tools, saws and knives.
Today, together with his son Dennis, Hajo Wagner is the owner of the BESTAR Group, which has been family-owned since 2006,. As of July 1, 2017 he became the chairman of the supervisory board of the company while Dennis became CEO.
In his spare time, he devotes himself to his family and his favorite Football teams, the SSVg Velbert and Borussia Mönchengladbach. He likes to spend the colder months with his wife Brigitte on the island of Lanzarote.


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The Doctoral Colloquium of the International Marketing Trends Conference which will take place in Venice (Italy) on Thursday 17th of January 2019.
The Doctoral Colloquium invites outstanding doctoral students in an intermediate or advanced stage of their dissertation process to discuss their work during a 50 minutes presentation in front of a panel of 8-10 leading academics. The Doctoral Colloquium is an International and friendly one-to-one environment, It is a unique opportunity to to refine research questions, publish research, receive guidance on future research directions and gain advice from the panel of professors on how to build an academic career. During the Doctoral Colloquium, each participant is given 20 minutes to introduce his/her work (15 slides max) in English and 20-30 minutes to discuss his/her proposal with the panel.
The Doctoral Colloquium was founded by Professor Elyette ROUX (Université Aix-Marseille, France) in 2008. It has been chaired by Professor Michael LINGENFELDER from Philipps-Universität Marburg (Germany) and is now chaired by Professor Jean-François LEMOINE from Université Paris 1 Panthéon Sorbonne / ESSCA School of Management (France).
In order to submit a proposal for the Doctoral Colloquium, please follow the steps indicated hereunder:
- Click here and read carefully the Doctoral Colloquium Submission Rules before connecting to the submission procedure.
To connect to the Doctoral Colloquium submission area, please click here.
Deadlines for submission and registration :
- December 10th 2018: submission of proposal and all the required documents on the website http://papers.marketing-trends-congress.com/
- December 17th 2018: notification of proposal acceptance
- December 17th 2018: registration and payment of conference fees (170 Euros)
- January 17th 2019: International Marketing Trends Conference


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Gaza City - Hamas policeman clashed with members of a Salafist group in the central Gaza Strip on Tuesday, as they raided a house during a search for suspects in the murder of an Italian activist.Witnesses at the scene said Hamas security officials were trying to raid a house believed to contain two suspects in the murder of Vittorio Arrigoni, who was found hanged last Friday hours after his kidnapping.Local residents said Bilal al-Omary and Abdul-Rahman al-Birziti, two of three suspects Hamas has said it is hunting, were believed to be inside the house in the Nuseirat area in central Gaza.As police neared the house, a gun battle broke out, witnesses said, adding that one person was believed to have been wounded, though a spokesperson for the Hamas health ministry said he had no details on injuries in the clashes.The Hamas-run interior ministry announced that part of the central Gaza Strip had been sealed off as their security forces searched for "wanted men", but gave no additional information.AFP reporters who tried to approach the scene were held back by Hamas policemen, but gunfire could be heard coming from the direction of the house in the central Nuseirat neighbourhood of Gaza.Hamas officials have said they have arrested two people in connection with Arrigoni's murder and named three suspects who remain at large - Omary, Birziti, who is Jordanian, and Mohammed al-Salfiti, a Hamas policeman.Salafists are Muslims who espouse an austere form of Sunni Islam that seeks a return to practices common in the early days of the faith.
This place is a militant mess!!
The only answer is: Pack them all up and send them back to Egypt/Jordan/Syria from whence they came.
Britain must must pay the bill because it was during their occupation in 1930-40s that the settlement (migrant labour) started!!!!


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This football uniform design was worn on the road by the Miami Hurricanes during the 2014 season. The uniform was created by Nike and we currently have 24 Miami Hurricanes uniforms in our database on Uniform Critics. Take a look at the other uniforms for this team and let us know which one is your favorite by rating them and leaving comments.
Before you can submit your rating for this football uniform, you need to register as a part of our community of uniform critics and log in on the website. What are you waiting for? All the cool kids are doing it!
In South Florida, football is played with a sense of speed and style that transcends the field of play. The University of Miami Hurricanes have become more than a team — they embody the soul of Miami and have defined the culture of the sport.
The new Hurricane uniform design reflects the vibrant, bold style of the city — from the beach to the architecture to the people. Steeped in tradition, the new aesthetic is anchored by the familiar orange and green colors, as well as the iconic split-U logo. Modern accents have been added in order to harness the team's early cutting-edge style both on and off the field in the '80s and '90s.
The white jersey and pant combination is accented with green at the shoulder, and serves as the foundation of the away look. The white uniform is also capped with a matching white and silver helmet. The University of Miami football team calls this the "Stormtrooper" uniform design.
At Uniform Critics, we are constantly looking to add more uniforms to our database and complete the uni history for each team. As we mentioned above, we have 24 uniforms in the system for the Miami Hurricanes, which you can scroll through below the comments section. Give us your feedback on each of them by sumbmitting your rankings and leaving comments. This will help us appropriately analyze the opinions of our community of uniform critics. If you want to become more involved, contact us with any uniforms we are missing and share our website with your friends that are sports fans. We appreciate your help and hope you enjoy your time browsing the website.


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I'm not saying this will be enough for Minnesota to pull the upset, but it sure as hell helps and it's just one more reason why the ridiculously long hiatus between the season and the Bowls makes no sense whatsoever.
"There I was, watching the first half-hour of the Gophers' first practice, and I'm seeing I-formations. I'm seeing fullbacks. I'm seeing offensive linemen put their hand on the ground... Quarterback Adam Weber opined that the Gophers could line up with two backs and the QB under center as much as 40 percent of the time once everybody has the changes down cold. Now, that might not happen by the time Minnesota plays in the Insight Bowl. But you can bet you'll see some of it against Kansas."
By the way, this link came to us via Gopher Football which has also posted a podcast with our old pal DJ from HawkDigest.


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This book is an angry exhortation against the Western model of development - its theory and practice. But anger has not blunted the authors' sense of humor. The book is marked with numerous punch lines which serve simultaneously to highlight and mitigate the anger and exasperation. It tries to demonstrate that the Western model of development cannot be sustained except by eating away the resources of the Earth far beyond its capacity for regenerating them and polluting it to an extent that survival itself would become problematic. It seems there is a little girl in Bombay who had never seen a live butterfly. The author says 'if the Western system of 'development' is permitted to endure, of one thing we can be sure: soon, not only will butterflies vanish, but little girls too'.
The different chapters of the book elucidate the above thesis in various spheres of life -agriculture, health, forestry. It begins with history and shows how the colonial government of the British undermined and impoverished every aspect of Indian life. On the other hand, Indian society is shown, with reference to the lifestyle of the Warlis, a tribal people of Maharashtra, to be simple and self-sufficient but at the same time dynamic and creative. For example, Warlis' way of catching fish is so delightfully simple and efficient! The authors move on from Warlis to record the shattering impact of modern development, some of it irreversible, on agriculture, health and forestry. They show through examples how the colonial exchange of wealth for poverty is continued after independence through the agency of the trans-national corporations whose means to get rich is nothing short of the immoral. They also explicate the hidden violence in the praxis of modern development-violence against plants, animals and fellow human beings. In each of the chapters practices which are based on renewability and which promote sustainability are described in some detail. The chapters contain a lot of useful information complete with references for those interested in developing sustainable alternatives.
The book has undertaken another major task - arguing that models of 'sustainable development' as proposed by the West, for example, in Pearce Report, are not so much about sustainability as about 'acceptable rate of economic growth', or worse, 'sustaining the Western economic system'. The interesting point about this exercise is that it uses the conceptual framework of the Pearce Report itself to argue against its conclusions - concepts like intergenerational equity, intra-generational equity Pareto optimality, benefit –costing the environment, etc.
The last few chapters of the book indicate some of the philosophical principles which can become the bases for disengaging ourselves from the harmful developmental path on which every nation in the World has set out. While admitting that it is not an easy task to do it, the authors urge individuals to start with themselves. The West has successfully persuaded the whole world that the monster of development is an economic necessity. To try to change this stream of opinion would be to confront vested interests at every turn. The magnitude of the task is enormous but the authors urge that individuals start with their own lives, by reducing the purchase and use of non-necessities. 'Reducing one's consumption need not wait for politician's pronouncements or economists' encouragement. The problems have global dimensions but they work through, individuals, and this gives each of us the power to exert a decisive influence on the world'.
Author: Uma Shankari


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- The EU Economic Crisis – Reflections in the Opinions of Citizens and Experts
- Transatlantic Economic Relations and the Prospects of a New Partnership
- Rim versus Non-Rim States in the Arctic Region: Prospects for a Zero-Sum Game or a Win-Win One?
- Eu Enlargement and Migration: Scenarios of Croatian Accession
- The Hungarian National Minority in Slovenia: Assessment of Protection and Integration after EU Accession
Perhaps one of the most important challenges that the EU is currently facing is that of building public support for the Union project as the economic crisis develops, confidence in the EU future is weakened and member states turn to their own boundaries. Therefore, this research aims at identifying the public opinion on the economic future of the European Union in the particular context of the euro crisis, given the fact that utilitarian considerations represent a key driver for the Europeanization process. At the same time, we compare expert opinions about the impact of the crisis on the future of the European Union, as well as the perceptions of ordinary people. To accomplish the research goals, we conducted expert interviews with 11 of the most prominent economic experts in Romania and a national survey (N=1002). The study supports the perspective that citizens' opinions about the economic evolution of the European Union are largely based on their sociotropic and egocentric economic assessments. The crisis influences the perspectives on the EU, but only by tempering optimism, turning it into a moderate view. This result can be extended to other Central-Eastern states as well, due to their resembling paths. Also, experts indicate various scenarios when referring to the impact of the crisis on the EU's future, but beyond the variations, the prospects are neither optimistic, nor pessimistic, but rather moderate.
Keywords: European Union, economic crisis, euro, the EU's future, Central and Eastern Europe, Europeanization
The paper analyzes the international context in which negotiations between the European Union and United States on a Transatlantic Trade and Investment Partnership have been launched in July 2013. This context includes both the repeated failures of the Doha Round negotiations as well as the previous attempts and achievements of the European Union and United States to create a transatlantic partnership. The author considers that the current circumstances are more favourable for the successful finalization of the transatlantic partnership but, at the same time, stresses the sensitive issues that may delay or divert the negotiations. The paper concludes that there are many possible immediate positive consequences on economic growth and creation of jobs of the Transatlantic Trade and Investment Partnership as well as a high potential to expand its implementation in North America through NAFTA and in some other countries that have free trade agreements with either the European Union or the United States.
Keywords: Transatlantic Trade and Investment Partnership, free trade area, European Union, United States, TAFTA, NAFTA, economic integration, post-Doha Round negotiations, globalization
The present paper aims to develop a critical approach on one of the most urgent energy security challenges: the Arctic region. Until recently, it was considered to be a frozen desert, upon which no one raised any legal demands or interests. The global warming, the technological development and the increased need for energy resources had transformed the frozen High North into a very hot spot, where states like US, Canada, Norway, Denmark or Russia started an energy race that threatens to escalate. The Arctic became a strategic area given its opportunities: besides the energy resources, new commercial routes could become available for a longer period of time. But, due to legal uncertainties, the lack of coherent and direct legal procedures of international law, the Arctic game is an open one, in which any state can intervene and ask for a solution that is suitable for its interests. This aspect complicates even further the already unstable region. Some of the actors see the region as an international area, as a common good, where everyone has the right to explore or exploit, while the rim states see the Arctic in sovereign rights terms. Therefore, the game tends to complicate as non-rim players (the EU, China, Japan, NATO and South Korea) want to intervene in the region and try to influence its development.
Keywords: Arctic, game theory, non-rim states, zero sum game, win-win game
This paper analyzes possible incidence of pending Croatian EU accession that is to take place on the 1st of July 2013, on the labour migration from Croatia to the European Union. We apply panel data estimators using the data on emigration from 18 EU countries into Germany (which is the EU country with the largest share of ex-Yugoslav and Croatian migrants) in order to construct possible scenarios of Croatian migration to the EU.
Three scenarios of migration - pessimistic, realistic and optimistic - are drawn and the sensitivity of estimated coefficients on migration from Croatia into Germany during next 25 years is further discussed in detail. We conclude that, similarly to hypothetical Turkish accession, Croatian EU accession is not going to cause massive migration inflows.
Keywords: international migration, EU enlargement, Croatia, panel data, seemingly unrelated regressions
The following paper will focus on the issue of the Hungarian minority protection in Slovenia. The first section introduces the Hungarian national minority, its main features and historical evolution. The second one gives a historical view on the practice of minority protection towards Slovene Hungarians, from Communist Yugoslavia to the 'Europeanization' process in the country. Further on, the level of minority protection will be analysed both at theoretical and empirical level: firstly, through the theoretical analysis of the legal status of the Hungarian minority, taking into account five main headings (education, use of language, political participation, cultural life, information and the media); secondly, through the results of a field research carried out among minority members, in order to find out the nature and extent of possible discrepancy between theory and practice. The main research hypothesis is that Slovenia has established a successful model of minority protection in what regards the Hungarians. This statement is to great extent confirmed by the analysis of minority policies and legal provisions and, with some specifications, by the analysis of opinions and feelings of 'qualified witnesses' belonging to the Hungarian community.
Keywords: Hungarians, integration, minority, protection, Slovenia


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Answer: Hard turning is a term given to
machining Hardened steel with CBN (Cubic Boron Nitride)
tools for replacing conventional method of finishing by
grinding process.
Answer: Reduction in Machine & man
power cost by reduction in cycle time, improved accuracy,
flexibility to do intricate shapes and environmentally friendly
as chips produced can be recycled as compared to Grinding
Sludge & used coolant which is hazardous.
Answer: Carbon steel, Chromium Molybdenum
Steels, chromium steels etc. In existing customers hard
turning is being done on 70% in Case Hardened Steels, 20%
to induction Hardened steels & 10% others..
Answer: Transmission gears, Differential
Bevel Gears, Shafts, Bearings, Diesel Pump parts etc. in
Automotive. Construction, Machine parts, Oil Pressure parts
etc. in Engineering.
Answer: Components with Concave or convex
shape, with many surface to be turned like boring, Grooving
External diameter & face turning in single chucking,
Components with small bores, Components where linear/axial
dimension controlling is difficult in grinding Esc are good
examples of Hard Turning.
Answer: Hard turning can be applied to
Steel having Hardness from 45 to 68 HRc.
Answer: Yes Hard Turning can be applied
to any degree of interruption & for That Sumitomo has
suitable grades. The components like Splined shaft or bore,
Bore with keyway, holes on the face or bore etc. can be
Hard turned with Sumitomo Grades BN 250 or BN 300.
Answer: Generally H7 or 7 class Tolerance
& Surface Finish of Rmax 3.2 (Ra0.8m) is achievable
by Hard Turning. With a rigid set up customers are achieving
6 class (H6) Tolerance & up to Rmax 2.0( Ra 0.5m). With
the latest developed wiper edge inserts finish can be achieved
even finer than above.
Answer: Grinding being a operation in which
the cutting takes place by abrasion the heat produced is
much higher. This heat when goes to the component surface
it leads for the problems like surface cracks, Re-hardened
& tempered layers, which are no good for the life of
the component. Hard Turning being single point turning &
CBN being an excellent thermal conductive material negligible
heat is transmitted to the component surface. So many a
times Hard Turning is preferred to solve the surface Integrity
Problems faced in Grinding.
Answer: Any NC Machine can do the Hard
turning which has min. surface speed for the job to be turned
about 100Mtr/min. There is no extra power required in the
machine to do Hard turning only force as mentioned before
higher in case of Hard turning is Trust/radial outward force.
To counter that the job chucking & in case of boring
carbide shank boring bar is recommended if the overhang
of the bar is more than 3.
Answer: Usually 80 to 180 m/min is used
in Hard Turning depending on other machining conditions
like rigidity, chucking, overhang etc. We also have grades
for high efficiency machining on continuous turning where
the cutting speed can be as high as 250m/min.
Answer: In Hard Turning only thrust/radial
outward force is higher as compared to soft machining. Rest
of the forces i.e. Principal force (downward on tool) &
Feed force (axial force pushing tool in opposite direction
of feed) remain unchanged. Thrust force affects the dimension
in deep boring application (L/D of boring Bar more than
3), to counter this we recommend to use Carbide shank boring
bar. Sumitomo has introduced a special series of Boring
bars, for Hard Turning, made of 100% carbide. By these boring
bars the finish, accuracy & life of the tools can be
expected better than the conventional carbide boring bar
being marketed. For further details write to us or contact
our regional sales team.
Answer: The Thrust force, which is responsible
for the dimension, increases with increase in Hardness after
45 HRc. The variation in hardness by more than 5HRc can
result in variation of dimension produced. To counter this
variation in Hardness more than 5HRc should be avoided.
Answer: Grinding is multipoint cutting
operation where N number of abrasive particles produce the
ground surface by rubbing. This action creates irregular
peak and valleys so the surface graph is irregular. In contrast
Hard Turning is a process of single point turning which
will give regular feed marks and periodic surface profile.
Answer: Generally Hard Turning is recommended
in dry condition. Interrupted machining must be used only
in dry condition. Some conditions where use of coolant can
be helpful are Die Steels, applications where thermal distortion
is predicted.


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Mahogany Workplace friends,
We hope you've enjoyed the blog since its launch this summer. We love reading your comments and hearing your thoughts, and it's so much fun to create this space for us to learn and grow together.
We're working hard to form partnerships that will benefit all of us on this journey together. In exchange for your loyalty and support, the Mahogany Workplace is announcing our latest partnership, which includes a fantastic giveaway.
Lowe's Home Improvement is partnering with us to give away a $5,000 gift card to one lucky MW reader.
As a homeowner, I can think of 1,000 ways I'd use this cash for my own house. I'd list a few… but I'd get way too jealous. Read on to learn how you can qualify to potentially win a $5,000 gift card to Lowe's and really take a step toward adulting.
- Follow us on Instagram: @mahoganyworkplacecreative
- Tag a friend on Instagram under our Lowe's Home Improvement post.
- Subscribe to our blog by clicking this link and following instructions.
You can also share this post on Facebook and email it to family and friends who need a little home improvement and a chance to win, too.
This contest starts today, October 12, 2017. We'll draw a winner on November 6 and announce it via our subscription email. You can check out the blog for the announcement on November 9 and we'll post more about our lucky winner in late November. He or she will have the chance to talk with Ben and the MW team (via video chat) about their home improvement plans for the $5,000.
Thank you for reading our blog. We're fortunate to connect with you and make a difference in the world.
Ben Higgins & The Mahogany Workplace team


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x264Gui 0.9.6 beta1 – update
Now you can use a 8 bit input video with the "high444_8b" AVC setting. This will produce a 10bit video using high444pp. The other AVC setting "high444″ will produce the same video but with a 10bit input video.
I also added the support for "high422″ and "high444″ into the profile system: now when you create a profile with "–high444″ or "–high422″ the GUI select the 10bit x264 binary; so you can do what you want with the "–output-csp", "–input-csp", "–input-depth" and not only the two things provided with the "high444″ and "high444_8b" setting.
As always you can download this beta build from: download x264Gui 0.9.6 beta
Take in mind that this only the executable: so replace your local x264Gui.exe with this.


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5 Days of War
A drama set centered around the war between Russia and Georgia, and focused on an American journalist, his cameraman, and a Georgian native who become caught in the crossfire.
Against the Clock
After new CIA recruit, Kelley Chandler (Polish) is seriously injured during a mission, surviving only on life support, his wife Tess (Agron), a former CIA operative, becomes determined to find out what happened to her husband. As the details of Kelley's last mission unravel, showing that his accident was an inside job, Tess puts everything on the line to keep Kelley out of harm's way, even if that comes with dangerous consequences.
On his latest private investigation, a shamed former cop connects a murder case to a government conspiracy involving rogue agents from a top spy agency.
Beverly Hills Chihua
While on vacation in Mexico, Chloe, a ritzy Beverly Hills chihuahua, finds herself lost and in need of assistance in order to get back home.
Book Club
Four lifelong friends have their lives forever changed after reading Fifty Shades of Grey in their monthly book club.
City Island
The Rizzos, a family who doesn't share their habits, aspirations, and careers with one another, find their delicate web of lies disturbed by the arrival of a young ex-con (Strait) brought ...
Jake Vig (Burns) is a consummate grifter about to pull his biggest con yet, one set to avenge his friend's murder. But his last scam backfired, leaving him indebted to a mob boss (Hoffman) and his enforcer.
Dead Again
An amnesiac and a private eye find they might have a past life connection.
When the network of satellites designed to control the global climate start to attack Earth, it's a race against the clock to uncover the real threat before a worldwide geostorm wipes out everything and everyone.
Following a ghost invasion of Manhattan, paranormal enthusiasts Erin Gilbert and Abby Yates, nuclear engineer Jillian Holtzmann, and subway worker Patty Tolan band together to stop the otherworldly threat.
Black gangsters in 1930 Harlem fights Dutch Schultz who is trying to horn in on their numbers racket.
Kill the Messenger
Based on the true story of journalist Gary Webb. The film takes place in the mid-1990s, when Webb uncovered the CIA's past role in importing huge amounts of cocaine into the U.S. that was ...
Mamma Mia! Here We G
On the Greek island of Kalokairi, the daughter of Donna Sheridan, Sophie, finds out more about her mother's past while seeking guidance on how to handle her pregnancy.
Max Steel
The adventures of teenager Max McGrath and alien companion Steel, who must harness and combine their tremendous new powers to evolve into the turbo-charged superhero Max Steel.
My Dinner with Herv�
A look at the life of French actor Hervé Villechaize, co-star of the hit '70s TV series "Fantasy Island", who took his own life in 1993 at the age of 50.
New York, I Love You
Several love stories set in one of the most loved cities of the world, New York.
Ocean's Eleven
Danny Ocean and his eleven accomplices plan to rob three Las Vegas casinos simultaneously.
Ocean's Thirteen
Danny Ocean rounds up the boys for a third heist, after casino owner Willy Bank double-crosses one of the original eleven, Reuben Tishkoff.
Ocean's Twelve
Daniel Ocean recruits one more team member so he can pull off three major European heists in this sequel to Ocean's 11.
A spacecraft traveling to a distant colony planet and transporting thousands of people has a malfunction in its sleep chambers. As a result, two passengers are awakened 90 years early.
Rio 2
It's a jungle out there for Blu, Jewel and their three kids after they're hurtled from Rio de Janeiro to the wilds of the Amazon. As Blu tries to fit in, he goes beak-to-beak with the vengeful Nigel, and meets his father-in-law.
The Air I Breathe
A drama based on an ancient Chinese proverb that breaks life down into four emotional cornerstones: happiness, pleasure, sorrow and love. A businessman bets his life on a horse race; a gangster sees the future; a pop star falls prey to a crime boss; a doctor must save the love of his life.
The Godfather: Part
In the midst of trying to legitimize his business dealings in New York and Italy in 1979, aging Mafia don Michael Corleone seeks to avow for his sins while taking a young protégé under his wing.
The Lost City
In Havana, Cuba in the late 1950s, a wealthy family, one of whose sons is a prominent night-club owner, is caught in the violent transition from the oppressive regime of Batista to the ...
The Pink Panther 2
Insp. Jacques Clouseau teams up with a squad of International detectives who are just as bumbling as he is. Their mission: Stop a globe-trotting thief who specializes in stealing historical artifacts.
The Untouchables
Federal Agent Eliot Ness sets out to stop Al Capone; because of rampant corruption, he assembles a small, hand-picked team.
Jessica, whose father killed her mother and committed suicide, is a police officer. While investigating a murder, she finds herself in the center of her own investigation, when her former lovers start being murdered.


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I am trying to solve some sample test questions and am looking for shortcut to a problem.
Question: True or False "Every invertible matrix $A \in \mathbb{Q}^{n \times n}$ is similar to a diagonal matrix over $\mathbb{C}$"
I think the statement is true for the following reason:
Theorem: Let $D$ be a principal ideal domain and $A \in D^{n\times n}$ then $A$ is equivalent to a matrix which has the diagonal form $diag\{d_a,d_2, \ldots, d_r, 0, \ldots, 0\}$ where the $d_i \neq 0$ and $d_i | d_j$ if $i \leq j$.
The proof for this fact has a lot of steps and requires one to induct using a suitably defined notion of "length" on a non-zero element in $D$. I was wondering if there is a simple trick to this problem by using invertibility of $A$.


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When Kyle resident Ruben Cantu arrived at his property Monday morning, he realized the first phone call he needed to make was to his insurance adjuster.
He was forced to make the call after a mobile home located on his property near Mathias Lane and Golden Cove in Kyle was completely destroyed during Sunday's violent thunderstorm that raged through the area.
Cantu said no one was injured as the homeowners, who have not been identified, were out of town when the storm hit.
But the damage was evident the next morning as neighbors, whose yards were decorated with insulation from the totaled structure, went out to glimpse the damaged building for themselves.
"At least nobody was home," Cantu said to neighbor Mary Viescas regarding the amount of damage to the mobile home.
Viescas said the homeowners had just moved the mobile home onto the property had not yet secured it to the ground when the storm hit.
"They had just spent $7,000 remodeling it too," Viescas said as she surveyed the damage of her new neighbors' home.
Viescas said she and her husband, as well as other neighbors, heard a big "bang" during the storm, which could have possibly come from the wind ripping apart the mobile home nearby.
Viescas said damage to her own property was minimal; however, there were trampolines twisted into knots after slamming into adjacent houses along Mathias Way.
She added the gas company had to shut off service around 8:30 a.m. due to the lines being damaged by a flying trampoline.
On Tuesday, The National Weather Service confirmed two small tornadoes in the Kyle-Buda area. The NWS also confirmed a tornado in the San Antonio area that caused extensive damage to homes.
However, the storm which swept across Hays County, produced high winds that were as high as 59 miles per hour in the Kyle area.
According to the Pedernales Electric Cooperative's outage website, roughly 4,300 people experienced power outages in its service area at 1 a.m. Monday.
As a result of the storm, many fences across Kyle, including those in the Hometown Kyle subdivision, were damaged, said Kyle Police Chief Jeff Barnett. Damage was also reported at Central Texas Speedway.
Much of the more serious damage was seen in parts of east Kyle and in Niederwald.
Charlotte Carroll Green said in a message to the Hays Free Press that most sheds in the Kai Vista Neighborhood were damaged or destroyed in the storm. She said her shed room was blown across her driveway and her porch roof was "peeled back."
Niederwald resident Michelle Harris said she heard what sounded like a "roaring" sound similar to an aircraft engine revving up when the storm hit.
She said a 200-pound barbecue pit on her property was picked up and turned around. A basketball goal that was cemented into the ground was picked up and was "twisted." She believed a tornado may have swept through the area.
"If you've been in Texas long enough, you know," Harris said.


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Chicken Dinner
Join Mountainside as we bring back our popular Chicken Dinners! Held at Mountainside Senior Living on the first Friday of every month!
When: First Friday of Every Month
Time: 6:00-7:00 PM
Cost: $10 Adults, $5 children, kids under 3 eat for FREE
Dine in or Carry out
Menu for April:
- Fried Chicken
- Savory Baked Chicken
- Herbert's Famous Mac and Cheese
- Garlic Mashed Potatoes
- Home style Chicken Gravy
- Seasoned Collard Greens
- Sourthern Style Green Beans
- Homemade Dinner Rolls
- Assorted Desserts by Pastry Chef Val


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1) Property Consultancy
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5) Project Marketing


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Happy Sunny Sunday, all!
On a day like today, there is nothing more appropriate than some seriously pretty sandals, a floaty little sundress and copious amounts of ice-cream/frappuccinos/frozen-yogurt/Pimms (delete as appropriate).
If you are regular reader of my blog (hi Mum), then you will know that I am something of a girly girl with a penchant for all things glossy, pretty and cutesy. So, I am sure you can all imagine my elation on spotting these sweet Sophia Webster sandals on Never Underdressed.
I have been swooning over the bold, kitsch designs by Sophia Webster for a few seasons now, and these sandals (at Net-A-Porter) really embody the fun spirit of London's latest fashion force.
With yellow and pink polka-dots on the cylindrical heel and cartoon flamingos kissing at the clear perspex peep-toes, these adorable shoes are like Mr Blobby meets Barbie, in the coolest way possible.
Granted, they are not exactly a throwaway purchase at £315, but how could you ever be in a bad mood when wearing shoes that are so very jolly?
FUN FACT TIME. A group of flamingos is called a flamboyance... Such divas.
If this has whet your Sophia Webster appetite, check out these bad boys... More fabulous than a flamboyance.


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A month after commissioning his own tombstone, the quirky founder of the Dead Poets Society of America has died.
Walter Skold had enlisted the son of novelist John Updike to carve a unique tombstone that will be topped with a dancing skeleton and a quill.
Michael Updike, who received the poet's deposit last month, said he never expected to be carving the monument so soon.
Skold died Jan. 20, in Elkins Park, Pa., after suffering a heart attack, Updike said Friday. He was 57.
"He was a sweet soul," said Updike, of Newbury, Mass. "He was a kind person with this quirky predilection to poets' graves and death and the macabre."
Known as the "Dead Poets Guy," Skold visited the final resting places of more than 600 poets after launching the Dead Poets Society in 2008 in Maine, drawing inspiration for the name from the 1989 Robin Williams movie.
Along the way, Skold drew attention to bards and poetry while producing a massive repository of information on poets' final resting places.
He also had a sense of humor.
He traveled in a cargo van he dubbed the "Dedgar the Poemobile," sometimes embellishing the dashboard with an Edgar Allan Poe bobblehead.
While his graveside poetry readings -- and occasional cemetery sleepovers -- evoke the macabre, Skold insisted in a 2009 interview that his intentions are honorable.
"It's not really a morbid project but, rather, a way to honor our literary forebears and to historically resurrect their works," Skold said.
He was serious about honoring poets, and he launched a movement to create Dead Poets Remembrance Day on the Sunday closest to Oct. 7, the date Poe died.
"It takes a little chutzpah to say we're starting a holiday," he said in 2010. "But we believe it's a really good idea, and we hope it catches on."
He was especially intrigued by poets who've been forgotten altogether, whom he called the "doubly dead" because they suffered a second death when their works were "slowly consigned to literary oblivion."
Skold also discovered that the final resting places of many poets are unknown. In Maine alone, he found 29 poets whose final resting places were a mystery to the public.
The Library of Congress has said it believes Skold's effort was the first such literary undertaking, said Peter Armenti, a digital reference specialist whose focus is poetry, in 2009.
Many of the poets' grave locations are well-documented, but only to scholars and poetry buffs, Armenti said. Skold's effort attempts to make the poets' information accessible to the general public, and in doing so generate some interest in America's poets.
"I just think it's a fascinating project," Armenti said. "I'm glad somebody's doing it."
Skold was living in Freeport, Maine, when he left his job as a public school technology teacher to pursue his passions of poetry and photography and to launch the society.


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Use Our Online Tennis Scheduler - The easy way to sign up for drills, clinics, lessons or reserve a court!
Log In to access the scheduler
If you do not already have a User ID and Password for The Village Club website, you must create an account under LogIn at least 48 hours prior to using the Tennis Scheduler for the first time.
TENNIS at the Village Club
The Village Club is proud to offer quality tennis instruction for children and adults. Our junior programs include micro tennis for tots as young as 4 years old, 10 and under tennis using right-sized equipment for developing youth players, junior team tennis leagues, and summer junior tennis academy.Adult tennis programs at Village Club offer year around drills for all levels of players from 2.0-4.5 for both men and women. Adult league teams of mixed doubles, ladies and mens play both USTA and CTA leagues in spring, summer and fall. League fees are $70.00, this includes 3 team drills and tennis balls. Private lessons with our pros round out the adult program.
The Village Club is a great spot for social tennis, too! Round Robin play, Happy Hours, Sip and Serve Socials and other fun activities are all part of the fun at the Club!
How to Sign Up for Tennis Leagues at Village Club
SUMMER PROGRAMS AND TENNIS CAMPSDirector of Tennis - Laura Sargent
Laura's impressive resume, talent, and dedication to working with players of all levels and abilities make her a great instructor for all levels of players. Laura has great programs for tots, juniors, adult women and men. Laura works year-round so when weather permits, she is teaching drills, junior practices, and is available for private lessons for children and adults.
Laura is on the court: 8:30-7pm Mondays-Thursdays
9am-4pm Fridays
8:30-1pm Saturdays
8:30-12pm Sundays
When she gets off the court she will be answering emails
Drills are every week, YEAR-ROUND, weather permitting. Please use the Tennis Scheduler to register for drills no later than 5pm the day before. . If only 1 player, drill is shortened to a 30 minute private lesson. If 2 players, drill is shortened to 1 hour. 3 players or more, drills are 1 1/2 hours. All 90 minute drills are $25 for members, added to your member account. If weather is questionable, drill status will be updated on the VC tennis scheduler.
In order to register for drills, you must do so through the Tennis Scheduler. The link to the Tennis Scheduler is at the upper right column of the tennis page. You will be able to click on it once you have logged in.
Tennis Spring Drill Schedule - NEW as of April 22st 2019
The Village Club also offers PLATFORM TENNIS, aka "Paddle". Our lighted court is available year round for players of all ability. The adjacent fire pit and seating area make for a cozy conversation area to warm-up after match play. The Club has paddles to rent and paddle balls for purchase for players' convenience. Please remember to RESERVE the COURT and turn out all lights by 10pm.
We've recently discovered pickle ball and WOW are we having fun! The Club has paddles and balls for members to use to get a taste of this addicting game! Keep your eye on the newsletter and club calendar for planned pickle ball socials, mixers, and "how to play" events!


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Osmo: Hands On, Educational Family Fun With Your iPad
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Dell Inspiron 15 i5555: A High-End Laptop With A Budget-Friendly Price Tag
This is a sponsored conversation written by me on behalf of Microsoft . The opinions and text are all mine.When I first got my hands on a brand new Dell Inspiron 15 with a touchscreen, I was instantly impressed. As part of a new collaboration with Microsoft, I … [Read more...]
A Connected Home Can Help You Keep Your Family Safe
You probably know by now how important I feel it is to keep your family safe. Now there's an affordable way to have peace of mind even if you're not home. I've been trying out Kidde's RemoteLync ($99), a listening device that alerts you via a free app whether your home might be … [Read more...]


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Tuesday, September 25, 2012
First Jeans Day of Fall 2012!
So it was still almost 80F yesterday, but I wanted to wear jeans, gorshdarnit! Plus, I wanted to try on that Lululemon jacket I'd been eyeing, and I wanted to try it on with the type of bottoms I'd likely pair with it. The result was my transitional variation on jeans and a plain white tee. A man at the gas station said my "image" made his day - and not even in a creepy way. I think. While I was at it, I took my Frye Vera boots out for their maiden voyage. The jacket I tried did not work out, but at least my outfit did.
This morning is also the first morning that Hank has demanded to occupy my lap since summer started. Change is in the air, people! My coats will be able to come out and play soon soon soon.
H&M studded tank - YLF swap party
Hudson Signature Bootcut jeans - flea market
Destroyed men's belt - flea market
Dana Buchman leather bag - flea market
Crystal Bullet necklace - gift from a friend
Frye Vera boots - Amazon
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Download full speaker biographies here
David Rosenberg is an English solicitor and Vice President IP Policy at GlaxoSmithKline.
He has a law degree from Exeter University and before qualifying as a solicitor he spent 3 years doing legal research and teaching in the UK and US.
He worked for 12 years in the IP department of Clifford Chance, engaging in litigation and transactional work, primarily in the patent field.
He joined GSK in February 2000 to perform a policy role in the IP department. He has worked on many aspects of IP policy in and outside the EU including access to medicines issues.
He represents GSK on the IP committees of several pharmaceutical industry organisations and UK and European cross-industry organisations. He chairs the IP committee of the European Federation on Pharmaceutical Industries and Associations (EFPIA) and in that role was heavily involved in the sector enquiry into the pharmaceutical industry led by DG Competition which concluded in 2009..
He has been deeply involved in the discussions within industry and with the UK IPO and Commission to create a unitary European patent and unified patent court.
David is a regular speaker (and, when he has to be, very occasional author) on these issues.
Dr. Ghafele holds a Lectureship in Intellectual Property Law at Edinburgh University. Within the University of Oxford, she holds Fellowships at the Said Business School, the Oxford Intellectual Property Research Centre and St. Cross College. Until 2011, she also had a Lectureship with the University of Oxford and a Research Scholarship with the Haas School of Business, University of California at Berkeley. In 2011 she set up Oxfirst Ltd., which seeks to offer new insights on the economic aspects of intellectual property. Her work focuses on IP management and Open Innovation, IP monetization and the establishment of financial markets for IP.
From 2002 to 2007 she worked with the U.N.'s World Intellectual Property Organization (WIPO) and the Organization for Economic Cooperation and Development (OECD). In this role she offered strategic advice on Intellectual Property, Trade and Innovation to Governments in Europe, Asia and the Middle East. In 2000 she started her career with the management consulting firm McKinsey & Company, where she moved from a five year long experience as a ballet dancer.Her Ph.D. was awarded the Theodor Koerner Research Prize by the President of the Republic of Austria. Dr. Ghafele was trained at Johns Hopkins University, School of Advanced International Studies, the Sorbonne and Vienna University. She is fluent in German, English, French, Italian and Persian.
Catriona Hammer joined GE in April 2004 through the acquisition of Amersham and now manages the Intellectual Property department for GE Healthcare. The department is a global team based in 9 countries providing full IP support for GE Healthcare's businesses, covering technologies from research tools to medical equipment. The department works on all aspects of IP from idea generation through to exploitation of IP.
Before joining GE, Catriona worked in the pharmaceutical industry, in the Intellectual Property departments of GlaxoWellcome and The Wellcome Foundation. Prior to that, she worked in a firm of patent attorneys.
Catriona holds a degree in Biochemistry from Oxford University and professional qualifications as a Chartered Patent Attorney and European Patent Attorney. She sits on Council for the Chartered Institute of Patent Attorneys as well as its Patents and Parliamentary Committees and chairs its Finance and House Committee. She is also a Council member for the IP Federation.
Harry Thangaraj is a researcher into IP and global access to essential medicines based in St. George's University of London. He coordinates a collaborative research project entitled "Access to Pharmaceuticals" funded by the European Union under its 7th Framework Program (Health). The project deals with "socially responsible licensing" as a means to enhance access to essential medicines particularly for poorer countries. After several years of research in biomedical sciences he pursued IP studies at Queen Mary University London, where he won the GSK prize for highest score in patent law examinations in 2004/5. His main research interest lies in Socially Responsible Licensing. Apart from academic research he is passionate about travel and photography.
Belinda joined the UK Intellectual Property Law department of IBM in January 2004. The department provides all aspects of IP Law support throughout most of Western Europe as well as the Middle East and Africa, and covers technologies from materials science, semiconductors and microelectronics, to computer software and hardware. Belinda has been head of IBMs UK IP Law department since March 2011.
Before joining IBM, Belinda worked in London in private practice. She holds a degree in Physics from Bristol University and professional qualifications as a Chartered Patent Attorney and European Patent Attorney. Belinda is also a Council member of the IP Federation and a member of the IP committee of the Confederation of British Industries (CBI).
Pablo Tapia is the subsidiary attorney for Microsoft Research in Cambridge, UK, and the Advanced Technology Centers in Aachen (Germany), Herzliya (Israel), and Cairo (Egypt). He currently manages patent filing and prosecution strategy for Microsoft Research EMEA in patent offices including USPTO, EPO, and SIPO. In addition to patent issues, Pablo counsels clients on general IP issues, open source, EU funding engagements, and IP licensing. In previous roles at Microsoft, Pablo has managed patent portfolios for other Microsoft's R&D efforts in India and in China.
Before joining Microsoft, Pablo was a patent attorney at Greenberg Traurig in Los Angeles, California and a software engineer at Motorola in Phoenix, Arizona. Pablo received both his JD and B.S. Computer Science from Arizona State University, and is admitted to practice in California, Arizona, and the US Patent and Trademark Office.
Yves Reboul is emeritus professor of the University of Strasbourg, former Director General of the Centre for International Intellectual Property Studies (CEIPI) and Director of the French Department. Director of the professional Master 2 in intellectual property in the Knowledge Society, professor in industrial property law at ENSTA – PARIS'TECH Ecole Polytechnique and in Trademark Law at Sciences Po Paris. Yves Reboul is an Honour professor of the University of Chongqing – China, Scientific Director of the collection «Patents» of Jurisclasseur, Lexis Nexis Editions and Doctor of Law «The Contracts of Research» and author of many works of research and publications in the field of intellectual property.Yves is supervising several Master theses and ongoing doctorate theses in intellectual property.
Dr. Zongliang (Stephen) Zou is a partner of Lung Tin, where he focuses on patent matters, primarily on patent application preparation and prosecution in the fields of pharmacy, chemistry, and biotechnology, as well as on patent invalidation, litigation and regulatory affairs before the State Food and Drug Administration. In particular, Dr. Zou has rich experience in providing clients with patent infringement analysis. Dr. Zou joined Lung Tin in 2012.Since Dr. Zou started his professional as a patent attorney from March 2003, he has been entrusted by several multinational pharmaceutical giants to handle their patent matters in China, help them obtain regulatory approval, and help them solve IP matters in drug pricing & drug bidding activities.Prior to joining Lung Tin, Dr. Zou had served in a well-known IP firm as a patent attorney and then a partner for over nine years.Prior to his legal profession, he was an assistant professor at Beijing Institute of Radiation Medicine affiliated with China Academy of Military Medical Science.
Kate handles a diverse portfolio of technologies in the life sciences and biopharmaceutical fields, including diagnostic and therapeutic targets, SNPs, antisense nucleic acids, GMOs, antibody and peptide therapeutics.
Kate has considerable experience of drafting patent applications and developing IP filing strategies in the life sciences field. Kate co-ordinates global patent portfolios for UK universities, spin out companies and international corporations. She has a substantial prosecution practice and is highly experienced in acting before the European Patent Office in prosecution, opposition and appeal matters, including attending oral hearings. She has particular in-depth knowledge of the complex legal issues surrounding the enabling nature of deposited biological material.
Kate regularly provides opinions on the most appropriate ways to protect platform technologies, including performing freedom to operate analysis. She has extensive experience in conducting due diligence, including performing patentability and validity analysis, in respect of pharmaceutical and life sciences technologies.
Mike specialises in the pharmaceutical field and has considerable experience in due diligence evaluations, licence negotiations, patent term extension, regulatory data exclusivity and patent listings with regulatory authorities. Mike also focuses on the drafting and worldwide prosecution and defence of new chemical entity, formulation, drug delivery, salts, crystalline forms, co-crystals, process and use patents. He additionally has considerable experience in oppositions and appeals at the European Patent Office.
Mike started his patent career with a major speciality chemical company where he worked on a range of technologies including dyestuffs, ink formulations, electrophotography and industrial biocides.
Prior to joining HGF, Mike worked in-house for more than ten years for a global pharmaceutical company. There he managed patent matters across all stages of pharmaceutical research and development, including drafting, litigation, opinions, freedom to operate evaluations and providing strategic IP advice to both technical and management teams within the business. Mike coordinated global patent litigation strategy for a major product which involved briefing technical teams to prepare evidence, advising senior stakeholders and coordinating preliminary injunction, infringement and revocation actions.
Mike also provided support to business development activities and worked on numerous due diligence evaluations and negotiations including early stage discovery agreements, peer-to-peer collaborations and late stage product acquisitions and in-licence agreements. Mike is able to draw on his broad experiences to provide clients with commercially focussed and pragmatic patent and business development strategies. He can therefore act as a quasi-in house patent counsel for clients, working with both scientists and management to guide commercial and technical developments, thereby maximising the value which IP gives to the business. Alongside these skills, Mike has the expertise required to implement the patent strategy in the day-to-day conduct of client's patent activities.
Chris principally handles patent matters in the areas of electronics, telecoms, computer software and physics.
Chris has prosecuted and advised on patents relating to electronic circuits and systems, including computer processors and semiconductor devices, computer based inventions, such as graphics processing, computer algorithms and computer communications, consumer electronics such as navigation devices and home electronics, and also carbon nanotube-based inventions.
Chris represents a wide range of clients from multi-national companies to start-up companies at the outset of developing their IP portfolio. Chris regularly attends proceedings at the European Patent Office, particularly before Examining Divisions. Chris has also represented clients in proceedings before the UK Intellectual Property Office.
Paul is a valuation and transfer pricing specialist based in the London Office of Charles River Associates (CRA). During his career, Paul has helped multinationals in a wide variety of industries with many different transfer pricing and Intellectual Property-related issues.Paul's work has included identifying and valuing different types of intangibles, evaluating economic substance and risks, and designing commercial transfer pricing policies. His experience ranges from designing practical documentation solutions to helping major companies defend complex intercompany arrangements. Before joining Charles River Associates, Paul held senior transfer pricing economist roles at KPMG and at Deloitte. He has a MSc in Econometrics and Mathematical Economics from the London School of Economics and a BSc in Economics from Manchester University.
Gordon heads the Wragge & Co IP team and has over 25 years of experience across the full range of IP rights.
Although recently more focused on multi-national patent litigation, Gordon started his career fighting the car panel design cases and represented the spare parts industry in the leading European Court of Justice case of Veng v Volvo. He returned to the ECJ years later in the leading comparative advertising case of O2 v H3G. He secured eventual victory for his client in the long-running patent entitlement dispute, Cinpres v Melea, and has recently won a series of patent trials in the High Court and the Patents County Court, most notably in another long-running case, Virgin Atlantic v Zodiac Aircraft Seats.
Gordon took over the leadership of the IP team in 1995 and since then has led it successfully into London, Munich and China. The team, which now features 13 partners and 50 lawyers around the world, is a regular nominee for, and winner of, major awards and covers the full range of IP work. Gordon travels regularly to China where his team of IP specialists have fought over 100 cases for UK and US based rights owners.
Gordon is an Associate member of the Chartered Institute of Patent Attorneys and the Institute of Trade Mark Attorneys. He is a World Intellectual Property Organization panelist for domain name disputes and a mediator accredited by CEDR and WIPO. He is one of the most experienced mediators of IP disputes in the UK. He writes and speaks widely on IP related topics and produces a much acclaimed annual review of patent cases which is known to be read with some trepidation by the IP judges.
He has direct litigation experience in most of the key IP jurisdictions, including nearly every country in Europe plus very extensive experience in the US and the Far East. Outside Europe David has handled IP issues in the USA (at least 20 states), Canada, Ecuador, Brazil, China, Korea, Taiwan, Japan, Thailand, Australia, New Zealand, South Africa, Nigeria, India, Saudi Arabia and the UAE.
David is frequently called upon by clients to co-ordinate the activities of external counsel in multiple jurisdictions and is often relied upon to select advisors in jurisdictions unfamiliar to the client.
Marek Lazewski is a managing partner at LDS Lazewski Depo & Partners, one of the leading Intellectual Property practices in Poland. He specializes in complex patent, trademark and design prosecution and litigation; involved in life-cycle management of a highly successful international pharmaceutical product; supervising and conducting prosecution, validity and infringement proceedings in Poland related to patents. He also has considerable experience in representing litigants at the CTM court in Warsaw. He is the author of various publications on the intellectual property addressed to Polish entrepreneurs and a frequent contributor at conferences and seminars. Marek advised the Polish Ministry of Economy on the legal and economic problems involved in the introduction of the Community Patent in Poland. Moreover, he participated as an expert in the European Commission Project "MAKING IPR WORK FOR SMEs - Enforcement Best Practices" in 2010.
Marek is a member of the following associations: INTA, FICPI, LES – he was a founder member and the first president of LES Poland, AIPPI – he has been appointed the Secretary of the Polish National AIPPI Group and Polish Patent Attorneys ChamberPolish Patent Attorneys Chamber – he was the Chief Disciplinary Prosecutor.
Mr. YIN is a Senior Partner of WAN HUI DA. Before his retirement in March 2010, he used to be the Spokesman and Director-General of Legal Affairs Department of State Intellectual Property Office (SIPO).
Mr. YIN holds an M.Sc from the Institute of Automation, Chinese Academy of Sciences and a B.Sc in Industry Automation Instrument from Chongqing University. Mr. YIN pursued, successively, further professional trainings in the United States Patent and Trademark Office (USPTO), German Federal Patent Office, German Federal Patent Court, and John Marshall Law School, Chicago of the United States. He also conducted a six-month research program in Max Planck Institute. He began his career with the State Intellectual Property Office since 1982 when the bureau was still known as China Patent Office. He consecutively held positions as examiner of the Patent Reexamination Board from 1985 to 1988, Director of Physical Appeal Chamber of Patent Reexamination Board from 1988 to 1994 and Deputy Director-General of the Mechanics Examination Department from 1994 to 1998. He was appointed Director General of SIPO Legal Affairs Department in 1998 and SIPO spokesman in 2007. During his tenure of office, Mr. YIN was in charge of drafting both the Second and the Third amendments to the Chinese Patent Law and its Implementing Regulations which was submitted to the State Council for approval. He led the SIPO delegation to the meetings of the Standing Committee on the Law of Patents (SCP) on stipulating the Substantive Patent Law Treaty (SPLT) and the Working Group on the Reform of the Patent Cooperation Treaty (PCT) organized by the World Intellectual Property Organization (WIPO) and presided over the meetings as Vice Chairman. Mr. YIN also participated in the formulation of the "National Intellectual Property Strategy" as the team leader on compiling the research report for IPR agency service system.
Mr. YIN is currently a council member of the China Law Society, a standing council member of the China Intellectual Property Society, a member of the Committee of China International Economic and Trade Arbitration Commission, an adjunct professor of Huazhong University of Science and Technology and Southwest University of Political Science and Law, an honorary professor of the School of Economic Law of China University of Political Science and Law and the Intellectual Property Training Centre of SIPO, a visiting professor of the Inns of Court of Renmin University, a consultation advisor of the Higher Court of Beijing Municipality, an IP adviser of the Higher Court of Shanghai Municipality and the Higher Court of Jiangsu Province, as well as an IP consultation adviser of the Higher Court of Shanghai and the Higher Court of Fujian Province. He was also granted the Special Subsidy for High-level Expert by the State Council in 2005 for his outstanding achievements in the field. Mr. YIN is also the director general of IPRC Intellectual Property Research Centre.
Bryan Diner, a partner with Finnegan, Henderson, Farabow, Garrett & Dunner, LLP, practices all aspects of intellectual property law, including strategic patent portfolio management, litigation, prosecution, opinion preparation, due diligence investigations, and interferences. His litigation practice has involved diverse technical areas, ranging from protecting the rights of innovative pharmaceutical companies in Abbreviated New Drug Application (ANDA) litigations to defending clients' right to use certain medical devices. He also has extensive experience in conducting IP due diligence investigations for all types of transactions.
Mr. Diner served as the managing partner of the firm's Brussels, Belgium office from 1998 through 2003. During his tenure in Brussels, he learned much about the European legal system, from the EPC to the diversity of laws and practice among the European national systems. Strategic portfolio management and litigation counseling to European clients is also an important part of Mr. Diner's practice. His knowledge of the European legal system and how it differs from that in the United States allows Mr. Diner to counsel both European and domestic clients on a full range of IP issues and to find cohesive solutions tailored to the needs of companies with global interests.
May / June 2019
From trademarks to trade secrets: in-house tips on brand protection in China
Despite the well-known struggles in protecting trademarks and trade secrets in China, there are some tried-and-tested strategies to employ, as Karry Lai and Ellie Mertens hear from in-house counsel at a range of domestic and international companies
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Nitrous oxide acts as a depressant (substances that slow down the activity of an organism or one of its parts) on the body. Once inhaled, the gas enters the bloodstream through the lungs. The blood then carries it throughout the rest of the body. It reaches the brain quickly, affecting vital functions such as breathing and heart rate. It also alters other mechanisms of the nervous system, effecting thought processes, behavior, and emotions.
Primary dangers of inhaling nitrous oxide are oxygen deprivation, frost bite, loss of motor control, vitamin B12 and folic acid interference, disorientation, hallucinations and nausea. There is always the possibility of tripping and falling while under the influence and becoming seriously injured, or worse.
With A's and B's in school you are a smart young person. I'm sure you realize abusing a product is not good and you should get help. In addition to abusing whipped cream toppings please evaluate your other risky behaviors like drinking, smoking, and selling drugs. I urge you to seek help for you addictions. Start by talking to a family member, friend, classmate, etc. about it. Talk to your school counselor or a local medical professional you have access to about local resources or counseling groups.
You have the gift of life, so please enjoy it and try to live it as well and healthy as you can. Though you stated you have "no parental guidance" you still have parents and family and friend who care about your well-being. Please heed corgidaze's warning and be safe. Please feel free to email me with any further questions or comments, email@example.com.
I know what you're feeling. I just emptied a can of hair moouse and inhaled the gas. I am still tripping!!!! I'm in love with this feeling!!!
o my god im with you there man
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The US President also expressed his full confidence in the director in functions, Michael Morell, and men and women of the CIA who work daily to keep our nation safe. Finally, said: my thoughts and prayers are with Dave and his wife Holly, who has done so much to help the military families through their work. I wish them the best in these difficult moments, Obama concluded. Military exemplary son of a Dutch sailor who came to the United States after World War II, David Petraeus was born in the State of New York on November 7, 1952, and since his youth, noted for its ease to practice all kinds of sports and good intellectual qualities. He graduated as a second lieutenant in 1974 at the Academy military West Point, where he was a star of skiing, football and where he finished as the 10th best record of your promotion.
Two months after his degree, he married his wife, Holly Knowlton, with whom he has two children. In parallel to his rise in the military career, received his Ph.d. in 1987 in the School Woodrow Wilson's public affairs and international of Princeton University with the thesis the American army and the lessons of Viet Nam. Four years earlier he had already been honoured with the award the brightest student from the University for senior and General of the army. Petraeus held positions of responsibility, as the Deputy to the head of State more of the SFOR of NATO in Bosnia or Chief of operations of the force of the UN in Haiti. In 2003 he was appointed to the North of Iraq, in command of the 101st Airborne Division. In addition, he has directed units of mechanized infantry and air assault in Europe, United States and Middle East. In June 2004, he was appointed first Commander of the multinational command for security in the transition of Iraq, until barely a year later, was again destined for United States at the head of the combined arms Center, considered the intellectual center of the army.


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October 30th, 2008
A few days ago the Yes on 8 campaign announced
"Through the grace of God, one of our most fervent supporters has agreed to make a sacrificial gift to match, dollar for dollar, whatever you and others can donate, up to a total of $1 million. That means that every dollar you give will buy two dollars in advertising time.
But they declined to identify the donor.
Now the No on 8 Campaign has identified the secret donor.
Alan Ashton, of Lindon, Utah, a Mormon and grandson of David O. McKay, President of the Mormon Church from 1951-1970. Ashton made his fortune in software.
Well now there's a shocker. A Utah Mormon.
Update: That software that Alan Ashton made his fortune in? Wordperfect. Ashton is one of the company's co-founders. This matches Bruce Bastian's donation of $1 million. Bastian is the other Wordperfect co-founder.
It's Tit for Tat.
Alan C. Ashton made his fortune with WordPerfect.
Bruce Bastian, co-founder of (guess what!) WordPerfect, made his million dollar donation to the NO on Prop 8.
Mr. Ashton and Mr. Bastian are probably not talking to each other after this.
Samantha Davis
Well, I guess this just goes to show that a fool and his money are easily parted…
I think bigots are a type of fool, don't you?
I often wish that my husband and I would win the PowerBall (When it hits $200 Million) and then donate $10 Million of it to each of the "No on Prop. xxx" campaigns around the country!
And still have plenty left over!
California – Vote "NO" on Prop. 8!
Arizona – Vote "NO" on Prop. 102! AGAIN!
Florida – Vote "NO" on Amendment 2!
Connecticut – Vote "NO" on Question 1!
Benjamin Clark
Isn't it Ironic that the very religion (the Mormon Church) that the Evangelicals tend to despise and brand as a "non-Christian cult" is actually out-donating them on this issue that they (Evangelicals) brought forth in California – prop 8? Joseph Smith, Brigham Young and other early LDS leaders would roll in their graves to know that the Church that Joseph founded is in cahoots with the enemy that persecuted the Mormon church from New York to Utah – the protestant/Evangelical.
We talked at Sunday brunch about that aspect. The Catholics and the Evangelicals are all sitting back with big grins on their faces saying: "Look how the Mormons are spending THEIR millions on this.â€
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Or email


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Humantics Foundation
Breast Implants: Recovery & Discovery
"Shining a light" on The Ravings of Quackbuster 'Publicist' aka "Barrett's Parrot"
Update 1/2/2007
Willa Dean Arnold Nidiffer
(click here to see her advertisements for Barrett on Yahoo)
Check out QuackWatchWatch Check out Barrett Vs Rosenthal for information on Legal Attacks while Nidiffer provided smear attacks.
Since all three plaintiffs she defends have lost to me ... she is now circulating defamatory webpages claiming I was arrested and bankrupt.
This is the level of Stephen Barrett & Terry Polevoy's tactics for their losing SLAPP suits.
Update of June 6, 2006 (under construction)
It's easy to tell when Stephen Barrett and Terry Polevoy are desperate.
Out comes the dirtiest fighter of their team, their faithful Nanaweedkiller, or the Reverend Cathy Credulous or whatever name Willa Nidiffer is using for her usenet attacks at that time.
Right after she joined their tirades against me (just after the first decision in my favor in their suit against me) my email boxes became filled with email bombs ... and my email addresses were forged and put on hundreds of lists. Another woman posting posting supportive messages about me received a similar treatment and a trojan horse. If you read this page I created to "shine the light back on her" ... her intention is clear. And it mirrors Polevoy's and Barrett's greatest desires regarding me.
Today, within a week of Nidiffer coming out of the shadows, two of my email addresses were forged and sent to me.
This poster of course, is one of the Quackwatch.org / Healthwatcher.net rag-tag posse guerrilla team. I didn't make it up ... they did. That's what they call themselves.
When Barrett & Grell lost all their appeals to me in October, 2001, just days later, it was Nidiffer who circulated a permanent website defaming me by lying that I had been arrested for selling crack cocaine in San Jose, Costa Rica.
This site will still come up in search engines of my name, making it look like I was arrested today ... this desperate and twisted team's greatest desire.
Willa Nidiffer, who hides behind that alias now, is the same poster as The Reverend Cathy Credulous ... click here to see her represent the 'quackbusters' so well.
Using usenet terrorists to attack those they are suing tells alot about the level of Barrett and Polevoy. Nidiffer was also part of a vigilante team that hired a Private Investigator to hunt me down called the SBIPrivateClub.
Nows she's back in full force.
I believe that currently it is Willa only (not Ted nor Teddy Nidiffer) posting under the Nanaweedkiller mask.
A Mere Sampling of Her Aliases, so ashamed is he to post under her/his own name.
... and ever so many, many, many more disguises of a decade long Usenet Guerrilla.
This poster specialized in Smear Campaigns for the Quack/Skeptic/Healthfraud Team for several years before focusing on smearing me.
Shining a light back on Nidiffer and Polevoy
If you look below at three of the Nidiffer identities ... you will notice that one is the office where I have received my mail in San Diego for around 17 years now.
That photo apparently was taken late Summer, 2004, when Nidiffer participated in the SBIPrivate Club ... SBI standing for Silicone Breast Implant. They hired a Private Investigator to hunt me down and attempt to access my bank accounts.
Terry Polevoy had been publicly raging about Costa Rica and more lawsuits around then. He had just been busted for affecting the disguise of "Vera Teasdale" on Usenet in July ... to the tune of 50 postings. He seemed to me to be having a public meltdown. As Vera, he would prance around interrogating me, insulting others of us he is suing, and advertising for his own Quackery site.
This was an especially stupid game he had enjoyed as his case against me headed towards the Supreme Court of California and being busted must have been humiliating.
Three of his Rag-tag Posse Members, Nidiffer being but one ... were hunting me down ... making me feel very stalked ... as had Christine McPhee. (Click here for details on his harassment of her.)
One of the SBIPrivateClub members repeatedly harassed the employees at this office ... and a man was seen going through our garbage. Nidiffer had a blast going on about the "Dumpster Diver" ... the PI paid to stalk me:
Neither Polevoy nor Nidiffer need know where I am physically located ... yet they have publicly obsessed about it.
If anything happens to me ... or my family ... Nidiffer and Polevoy should be investigated. Affecting disguises may be fun for them ... but they are frightening people with a twisted agenda and they back some of the most powerful corporations in the world.
Their filthy campaign against me shines the light back on them.
I've had enough.
WILLI Dean Arnold NIDIFFER
(410) 761-5157
I am creating this web page in Early May, 2005, nearly 4 years after Nidiffer began attacking me.
With the help of Myrl Jeffcoat . ... Nidiffer has been welcomed to the fragile breast implant support system with their blessings.
Another brief moment of honesty from Nidiffer came last Valentines.
A Valentines day poem for you.
Tear me apart and boil my bones
Nidiffer stormed into my life just days after all three plaintiffs from the Quackbuster Team lost their SLAPP suit against me in July, 2001 and made me his and/or her mark. Simultaneously Myrl Jeffcoat began her attacks ... wildly accusing me and those close to me of ugly crimes ... none of which are true.
Typical Smear Campaign propaganda ... they've never stopped since then.
"I must admit however, I am a Rev. Cathy Credulous "wannabe," and would
After Barrett & Grell also lost completely at the Appeals Court level in October, 2003 ... Nidiffer published this ditty ... so desperate and so revealing that nothing is too filthy for their Campaign against me. It backed up the lies Myrl had been spreading.
Perhaps it's Willa herself in the photo ... it has nothing in the world to do with me.
Myrl Jeffcoat was ecstatic.
NANA. . .That is toooooo funny for words. I'm on the floor laughing!
Click here for just 3 of the Nidiffer identities ... all advertising for so-called Quackwatch / Healthfraud / Skeptic Webring.
Head of this all, who I consider the epitome of a Quack by his own definitions, Stephen Barrett, one of my losing and disgruntled Plaintiffs, defines 'quackery' as "anything involving
Perfect description of Barrett, the Quackery Webring, and his Rag-tag Posse, of which Nidiffer is but one of his guerrilla attackers.
Two others from Barrett's 'vigilantes' are:
Posting literally thousands and thousands of posts ... since Willa and/or Ted began from the Baltimore Public Library in 1995 ... nowadays they are typically attacking someone that Barrett/Polevoy is suing ... win ... lose ... or draw. The more they lose ... they more base are their attacks.
The anonymity available on the Internet is perfect for their Guerrilla warfare ... decades of Barrett's work.
By the time Nidiffer began posting Usenet Assaults on me while simultaneously advertising for my losing Plaintiffs overtly ... there had been several other marks.
Barrett's network includes so called "skeptic" groups as well as the Health Fraud, junk science, anti-alternative medicine Network, the upside down and backwards named , "anti-quackery" webring.
They try to control the information on the internet ... Usenet and the WWW and chat rooms etc.
One part of the suit that Barrett lost involved whether or not the term "quack" was an opinion or a "fact."
The Superior Court and the Appeals Court sided with me that it is an opinion ... and mine is that Barrett and Polevoy are the ultimate Quacks.
Nidiffer is just one of their many "flacks" ... albeit a particularly revolting and frightening one.
Here are just a few quotes from thousands and thousands of Cathy aka Nidiffer on Usenet. This is who Myrl ... who calls herself a "legitimate" support group leaders, welcome into the breast implanted population.
Aren't you getting tired of breathing your own farts for so long?
I guess Nidiffer was discussing "boobs" here .. maybe that's why Myrl is so enamored with "Cathy"????
Brother Ray, I take issue with you associating yourself with
The NEW OXFORD
guerrilla (also guerilla)
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Ted and/or Mama Willa Nidiffer Version #1
Ted and/or Mama Willa Nidiffer Version #2
|For quick access to this page, bookmark: http://profiles.yahoo.com/nanaweedkiller
|To see his latest version of himself: http://profiles.yahoo.com/nanaweedkiller
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Michelle Morelan is an interior designer and illustrator from Vancouver Island. I am appreciating several aspects of her drawing technique shown in this image. One is her use of white space in her images. The other is that she will shift the room point of view to be lower that a typical eye level. Plan to visit her website Michelle Morelan Design to see her wonderful renderings.
She creates her images by combining technology, hand drawing and rendering. What a great way to utilize the efficiency of computer technology along with the personal touch that hand drawing and rendering gives an image. Her first layer is a perspective drawing of the space which is developed on the computer with SketchUp. On top of this drawing, she creates a line drawing by hand. Color and texture is added with marker. On her blog, A Schematic Life, you will see several video clips where she demonstrates her technique. You can learn more about her background and philosophy of design. Check this out!
You might be interested in seeing Jim Leggitt post who also uses SketchUp to start his images.
I enjoyed looking at her sight. I thought the box with samples, renderings and ideas was a great idea to give to your client.It was also interesting to see the sketch up design come to life with color.
thanks for the link and the kind words!!
What a cool designer! Love her technique.


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Before Rampage Jackson and King Mo take the stage at Bellator 175 tonight in Chicago, Mexican American MMA fighter, Emmanuel Sanchez (14-3) will look for his first win that isn't by the judge's decision in the co-main event against former bantamweight champion, Marcos Galvao (18-7-1).
Sanchez has won his last five out of six fights via decision but is very confident that he will get the finish tonight at the AllState Arena. "Every one of my fights I'm going for the finish," explained Sanchez. "I think that's why Bellator promotes me and puts me on the big cards because they know I throw down."
And the fact that he is on the same card as a legend like Rampage Jackson is just the icing on the cake for Sanchez. "Rampage was on the first MMA Pay-Per-View card I watched." said Sanchez. "I looked up to him coming up."
With Bellator bringing their brand to Madison Square Garden in New York this June, a highlight reel win over Galvao may be just what Sanchez needs to be a last minute addition to that monumental event. "I want to be in the biggest fights possible," said Sanchez. "I want to go out there and put a whoopin' on and hurt people."
Emmanuel Sanchez will face Marcos Galvao in the co-main event of Bellator 175: Rampage vs King Mo 2 LIVE tonight from the Allstate Arena in Rosemont, IL. This event will be televised FREE on Spike at 8pm CT.
Photo courtesy of Bellator.


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So - on my sequel - I did 350 words. They are good ones, but that's it for this check...sad. I know.
Sunday, April 10, 2011
Today is Sunday and my second check-in for this writing challenge! My first check-in I did really well. This one...not so hot. The last few days before a break are a bit crazy at school... but I fully intend to make up for it over the next few days and I am going on vacation so I will have plenty of time then!
Posted by Michelle Flick at 12:46 PM
Labels: ROW80
6 comments:
Ugh! I hate when life decides to intervene. Good luck with the rest of the week; I hope it goes awesome!ReplyDelete
- AnonymousApril 10, 2011 at 9:53 PM
350 words are still words so good on you! Hope next week proves more productive but small victories should still be celebrated.ReplyDelete
No worries - there's always next week! I hope you're able to catch up. :)ReplyDelete
Don't feel down. It's good that you wrote something. I was pretty behind with my goals too and managed to catch up and I know you will too. Good luck!ReplyDelete
Thanks for the encouraging words everyone!!!ReplyDelete
ROW80 sponsor here!ReplyDelete
350 words is more than you had when you started, which is great. Keep up the good work.
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The Rainforest Alliance is working with SalvaNATURA - a citizens' group with more than 50 active volunteers - to help to save El Impossible, the most important natural area of El Salvador.
Located in the department of Ahuachapan, El Imposible contains a highly threatened dry tropical forest that forms part of the coastal mountain range Apaneca-Ilmatepec. The 9,000 acre forest ranges from 900 ft to 4300 ft above sea level and is home to more than 500 species of birds as well as the country's most crystalline water.
Besides buying key habitat to add to the rainforest, SalvaNATURA is working with local residents to promote shade-grown coffee plantations as an alternative to hunting and fishing.
To save El Salvador's last expanse of rainforest before it vanishes forever.
This project has provided additional documentation in a Microsoft Word file (projdoc.doc).


text: An upstart from Seven Springs, Trevor Eichelberger has been making waves this past season, despite the fact that western Pennsylvania is hours away from the nearest ocean. Springs has provided ample training ground for Trevor, where fast laps through The Alley and Industrial Parkway have primed this young boarder for the transition into the streets. This year, Trevor's humble personality shone at The Launch and Superpark and we are excited to watch what he does in the coming winters.


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The field of cancer immunotherapy has made exciting progress for some cancer types in recent years. However, recent failures of late-phase clinical trials evaluating checkpoint blockade in patients with glioblastoma (GBM) represent continued challenges for brain cancer immunotherapy. This is likely due to multiple factors including but not limited to marked genetic and antigenic heterogeneity, relatively low mutational loads, and paucity of GBM-infiltrating T cells. We review recent and ongoing studies targeting the checkpoint molecules as monotherapy or in combination with other modalities, and discuss the mechanisms underlying the unresponsiveness of GBM to single-modality immunotherapy approaches. We also discuss other novel immunotherapy approaches that may promote T-cell responses and overcome the "cold tumor" status of GBM, including oncolytic viruses and adoptive T-cell therapy. Clin Cancer Res; 1–8. ©2018 AACR.
- Received April 12, 2018.
- Revision received May 31, 2018.
- Accepted June 1, 2018.
- Published first June 5, 2018.
- ©2018 American Association for Cancer Research.
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