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Volunteers have a very important role in schools and their assistance is greatly valued. This year, a new online training has been created by Brisbane Catholic Education (BCE) which is compulsory for all volunteers. In BCE, our commitment to the protection of students is based in our belief that each person is made in the image of God, and our ethos is to provide a safe and supportive environment for all. All students have the right to expect that the school will always act to protect them from any kind of harm.
If you would like to volunteer this year, before commencing your role as a volunteer in a Brisbane Catholic Education school, you are required to:
Parents/Guardians are not required to hold a 'Blue Card', however grandparents or other family or community members wishing to volunteer are required to obtain a volunteer 'Blue Card'. Please contact us for more information.
Please let us know if you are having any trouble completing the training or printing the form or have any questions. Thank you very much for your co-operation and help with completing this. We look forward to seeing our volunteers at school


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Some people find the oddest things troubling.
The irrationality of the anti-gay crowd amazes me. Sometimes, however, they are so bizarre and strange that they only bring about smiles and laughter. I've seen stand-up comics who aren't as funny as some of the Christianists, and the latter aren't even trying.
Most people have seen the rainbow flag, which symbolizes gay pride—except in parts of Europe where the flag, with the word "peace" on it, is an an anti-war symbol. Someone in Neptune, New Jersey, at a residents association meeting, wants the city council to look into banning the rainbow flag on houses. Their complaint reads:
"Ref: Display of sexual orientation flags," the question begins. "More and more, we are noticing flags being displayed on (Shark River Hills) properties declaring the occupants' sexual orientation or proclivity — not just the multicolored "gay' striped flags, but also banners indicating fetishes and or other "lifestyle' choices.Alas, this person's imagination is running away with them. I've lived in major cities and medium size cities, in various countries as well, yet never heard of, or seen, a flag for "fetishes and or other 'lifestyle' choices." Ooops, there is the Christian flag which I've seen used by various conservative churches. But other than that, I can honestly say I've never heard of such a thing. I suggest the only flat that has this person upset is the rainbow flag. If they can't get gays removed from "family oriented neighborhoods" (hey, Hans Hermann Hoppe would vote for that!) then at least they can get the flags out.
"While this type of display may be acceptable in certain gay enclaves, there is simply no justification for it in a family oriented neighborhood like (Shark River Hills.) Your comments?"
Meanwhile a politician from the conservative, religious-oriented Law and Justice Party in Poland is complaining that the local zoo purchased an elephant which appears to be gay. The politicians whines: "We didn't pay 37 million zlotys ($11 million) for the largest elephant house in Europe to have a gay elephant live there." It could be worse. The compound could be flying a rainbow flag or some of the other "fetish" flags that allegedly exist.
Meanwhile the police in Brooklyn, New York are up in a dither because a local pizzaria has a weekly gay night which includes male go-go dancers. (That isn't what I usually get when I order a pizza with sausage.) Captain Kennenty Corey, of the 76th Precinct promised: "We're going to determine the legality of it. If they're outside of it, then we're going to take action." I feel safer already. Police didn't even know about the weekly party until the New York Times ran an article mentioning it. Obviously they were flooded with complaints. The gay party is held on a night when the pizzeria, in the past, was usually closed. And the sign outside clearly says "Gay Party" to warn off the faint-of-heart.
Labels: bigotry, stupid government

subset: commoncrawl


text:
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Universe and Future of Humanity
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Book is described the arrangement of the Universe. This is the scientific prediction of the non-biological (electronic) civilization and immortality of human being. Such a prognosis is predicated... More > upon a new law, discovered by the author, for the development of complex systems. According to this law, every self-copying system tends to be more complex than the previous system, provided that all external conditions remain the same. The consequences are disastrous: humanity will be replaced by a new civilization created by intellectual robots (which the author refers to as "E-humans" and "E-beings"), These creatures, whose intellectual and mechanical abilities will far exceed those of man, will require neither food nor oxygen to sustain their existence. They may have the emotion. Capable of developing science, technology and their own intellectual abilities thousands of times faster than humans can, they will, in essence, be eternal.< Less
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Solutions for Health Insurance Providers
Busy parents are hard to reach. DYL will help you get in touch.
Why Health Insurance Providers Choose DYL
As a health insurance provider, you have unique business challenges. Whether it's your internet department following up with leads or your floor staff comparing quotes‐your phones are always ringing. With DYL, you will be able to streamline all of your activity with our powerful sales software.
Picture This:
A new customer fills out a form on your website, requesting information. Your internet department instantly calls the lead and gets an appointment within seconds. That customer doesn't even bother to talk to any other agents, since you were so quick to contact them.
Your sales reps are able to create leads for every inbound and outbound call, complete with notes and unlimited call recordings. They'll never miss a lead again. Later, your sales team makes hundreds of outbound calls to warm prospects ‐ at triple the speed of dialing by hand. Call reluctance is a thing of the past. Customers that were on the fence are now hot prospects.
Imagine being able to text your customers from your business number. Whether it's a quote, an appointment reminder, or to wish your customer a happy birthday ‐ you can do it all. Your entire sales process is automated: From follow-up calls to emails to text messages, DYL is the ultimate phone solution for health insurance providers.


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It's a funny old world,
Well it is when it's seen through the eyes of Brendan Grace. The sanctimonious priest who knows more than he's telling; "Blessed is she who gets married in the nick of time." The drunken parent making a speech at his daughter's wedding; "she could have married someone with money. She could have married someone who was working. She could have someone who wasn't working...but was willing to work." The schoolboy with the unspeakable habits and a fine line in sympathy pleas.
Brendan Grace is all of these and more.
Each cock-eyed portrait he paints has a ring of truth that brings audiences to the point of apoplexy. Unique, he is. But Brendan's material owes more to the best of traditional stand-up comics than it does to modern alternative humour. Sure, his voices are the voices of the people; but the subtleties of a nudge, a knowing wink and a throwaway line are his forte.
And there is sincerity about his act that endears you to him. You can't help but warm to his arm round – the – shoulder, "I'm on your side, buddy', personality. You can't help but escape the thought that if you met him in a bar, you would have a friend for life.
It is called charisma. And Brendan Grace oozes with it. Who does he remind you of/ you pick up hints of Benny Hill and Frankie Howard wit unashamed innuendo that takes you to the brink of vulgarity but never drops you over the edge. This is shaded with a delivery and a timing that would do justice to Bob Hope and George Burns. Then again , there is just a touch of the calculated lunacy of a Groucho Marx. And over it all, in the sidelong glance from those hooded eyes and the puff of chipmunk cheeks, you see a remarkable resemblance to a young Orson Wells. Even so Brendan Grace is very much his own man. A man who genuinely funny in his own right.
Ol' Blue-Eyes knows talent when he sees it.
To be feted by your peers is the finest compliment that can be paid to anyone in the public eye. To be applauded by one of the greatest entertainers in the business, then to be hired and given a contract to appear in a top-spot in London with the man himself is a dream come true. Yet this is precisely what happened to Brendan Grace.
For more information on Brendan Grace, please call us on 01 6190243 or email email@example.com


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Homestay is a programme undertaken by the Grenada Tourism Authority, aimed at increasing the number of quality rooms needed to augment the room stock and meet the demands of the Homestay Tourist. This programme invites Grenadian nationals and citizens with available rooms in their private homes to make these available to visitors for short-term rental.
Download Application form here
About the Host Homes
Host Homes are private, owner-occupied residences ranging from the simple to the elegant. Each home is different and decorated imaginatively to reflect the host's personal taste.
Hosts are individuals who enjoy meeting other people by sharing their homes and communities.
Approved Host Homes will be:
- Marketed by The Grenada Tourism Authority's (GTA) offices
- Listed on GTA's Website
- Able to participate in all training offered by GTA
Who Qualifies
The programme is open to nationals and citizens of Grenada only.
This programme does not extend to:
- Apartments let for residential purposes for periods exceeding two months
- Premises used exclusively for the accommodation of persons in religious, educational or charitable institutions
- Hotels, Guesthouses and Villas.
- A person who wishes to participate in GTA's Homestay Programme must apply for an inspection of the Host Home by completing and submitting the requisite application form to the Grenada Tourism Authority.
- Upon successful inspection, GTA will issue a certificate of registration, which will be valid for one (1) year, providing the minimum requirements for registration are upheld.
- A person who operates a host home shall apply annually to GTA for renewal of their registration certificate.


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Aviation History
SEPTEMBER 20, 1913. [/JJGHT] IKe Rocsal £[ero Clu of the United Kix\gdoi TIM OFFICIAL MOTICE.S TO MEMBERS BE Committee Meeting. A MEETING of the Committee was held here on Tuesday last, the 16th inst., when there were present:—Col. H. C. L. Holden, C.B., F.R.S., in the Chair, Mr. Ernest C. Bucknall, Col. J. E. Capper, C.B., R.E., Mr. G. B. Cockburn, Prof. A. K. Huntington, Mr. Mervyn O'Gorman, C.B., Mr. C. F. Pollock, Mr. A. Mortimer Singer, Mr. T. O. M. Sopwith, and the Secretary. New Members.—The following new Members were elected : — William Spencer Crabtree, Gordon Davson, Capt. Francis Ferguson, R.E., C. E. P. Long, James Welby Madeley, and Richard Crofts Powell. Aviators' Certificates. —The following Aviator:,' Certificates were granted :— 615 2nd Lieut. Howard Bertie Strong (Queen's Royal West Surrey Regt.) (Bristol Biplane, Bristol School, Brooklands). Sept. 3rd, 1913. 616 John William Wilfred Slack (Wright Biplane, Beattie School, Hendon). Sept. 8th, 1913. 617 Vivian Gaskell Blackburn (Bristol Biplane, Bristol School, Brooklands). Sept. 10th, 1913. 618 Walter Hugh Stewart Garnett (Bristol Monoplane, Bristol School, Salisbury Plain). Sept. 10th, 1913. 619 2nd Lieut. Lambert Playfair (Royal Scots) (E. A.C. Biplane, Eastbourne Aviation School, Eastbourne). Sept. nth, 1913. 620 Lieut. Nevile Morris Jenkins, R.A. (Bristol Biplane, Bristol School, Salisbury Plain). Sept. nth, 1913. 621 Lieut. Hyacinth Joseph Albert Roche (Royal Munster Fusiliers) (Bristol Biplane, Bristol School, Brooklands). Sept. 12th, 1913. 622 Capt. Arthur James Ellis (South Wales Borderers) (Vickers Biplane, Vickers School, Brooklands). Sept. 12th, 1913. 623 Lieut. Jack Armand Cuningham, R.F.A. (Bristol Biplane, Bristol School, Brooklands). Sept. 12th, 1913. 624 Cecil Le de Spencer Wynne Roberts (Vickers Biplane, Vickers School, Brooklands). Sept. 12th, 1913. 625 Francis Knox Haskins, R.N. (Vickers Biplane, Vickers School, Brooklands). Sept. 13th, 1913. 626 Colin Layzell-Apps (Vickers Biplane, Vickers School, Brook lands). Sept. 13th, 1913. The following Certificate was passed in France :— Harold Larpent Woodcock. The following Hydro-aeroplane Certificate was passed in America:— Ernest C. Bass. Accidents Investigation Committee.—On the motion of Col. H. C. L. Holden, the report on the fatal accident to Mr. S. F. Cody and Mr. W. H. B. Evans was unanimously adopted. (Full report will be found following these notices.) Competitions Committee. A meeting of the Competitions Committee was held here on Tuesday last, the 16th inst., when there were present: Col. H. C. L. Holden, C.B., F.R.S., in the Chair, Mr. Ernest C. Bucknall, Mr. G. B. Cockburn, Major F. Lindsay Lloyd, Mr. E. V. Sassoon, Mr. A. Mortimer Singer, and the Secretary. British Empire Micheltn Competition No. 1.—The con ditions for this Competition were altered, and appear in these notices. Paris-London Race.—Correspondence with the International Correspondence Schools and the Aero-Club de France was con sidered. The suggestion of the Aero-Club de France that the race should be from London to Paris and back was agreed to. In addition to the ,£700 deposited by the International Corre spondence Schools, the Aero-Club de France proposes to offer prizes up to ^600. The regulations will be drawn up by repre sentatives of the Royal Aero Club and the Aero-Club de France and it is hoped the race will take place in the month of October, starting and finishing at the London Aerodrome, Hendon. British Empire Michelin Cup No. 1, £500. The flights in connection with this Competition were, in the original rules, set down for certain dates, the closing date being Thursday last, the 18th inst. As no flights had been recorded on that date, the Committee of the Royal Aero Club, with the consent of the Michelin Tyre Company, has decided to extend the Compe tition to October 31st, 1913, and flights may 1* made on any day up to that time. It has also been decided to make a slight altera tion in the course, Farnborough being left out. The course is now confined to Brooklands and Hendon, and the following conditions stand :— The Michelin Tyre Company has presented to the Royal Aero Club of the United Kingdom, for competition by British aviators, a trophy of the total value of £500. Annually, for five years, a replica of this trophy, together with a sum of ,£500 in cash, will be given to the successful competitor. This trophy will be competed for under the following conditions:— CONDITIONS. 1. The winner for the year 1913 shall be the competitor who shall have accomplished the longest distance on an aeroplane in flight round the course, Brooklands, Hendon, Farnborough, on any day up to October 31st, 1913. 2. Flights shall be made between 7 a.m. and one hour after sunset. 3. No replenishments of oil, fuel, etc., will be permitted. 4. No repairs may l>e carried out after a start has been made. 5. Competitors shall make periodical compulsory stops of not less than five minutes, with engine stopped, on completing an entire circuit of the course plus one section, e.g., starting from Brooklands the competitor would pass Hendon, Brooklands, and alight at Hendon. His next flight would be from Hendon, passing Brook lands, Hendon and alighting at Brooklands, and so on. 6. Landing at any point other than a proper landing place terminates a flight, and the competitor will then be credited with the mileage of the sections which he has completed, in conformity with the regulations. 7. A minimum distance of 300 miles must be accomplished. 8. Starts may be made from any of the two points of the course. 9. The entrant, who must be the person operating the machine, must be a British subject, flying on a British-made aeroplane, must hold an Aviator's Certificate, and must be duly entered on the Competitors' Register of the Royal Aero Club. 10. The complete machine, and all its parts, must have been entirely constructed within the confines of the British Empire, but this provision shall not be held to apply to raw material. 11. An entrance fee of £1 must accompany every notification of an attempt, and at least three clear days' notice must be given to the Secretary, Royal Aero Club, 166, Piccadilly, London, W. A com petitor must further deposit a sum of ^10 on account of expenses, if any, of officials. Any balance not so expended will be returned to the competitor. 12. Should any questions arise at any time after the date of entry as to whether a competitor has properly fulfilled the above conditions, or should any other question arise in relation to them, the decision of the Royal Aero Club shall be final and without appeal. 13. A competitor by entering waives any right of action against the Royal Aero Club or the Michelin Tyre Co. for any damages sustained by him in consequence of any act or omission on the part of the officials of the Royal Aero Club or the Michelin Tyre Co., or their representatives or servants or any fellow competitor. 14. The aeroplane shall at all times be at the risk in all respects of the competitor, who shall be deemed by entry to agree to waive all claim for injury either to himself or his aeroplane, or his employees or workmen, and to assume all liability for damage to third parties or their property, and to indemnify the Royal Aero Club and the Michelin Tyre Co. in respect thereof. 15. The Royal Aero Club reserves to itself the right to add to, amend, or omit any of these rules should it think fit. The Gordon-Bennett Balloon Race. The Gordon-Bennett Balloon Race will take place in Paris on Sunday, October 12th, 1913, and the representatives of Great Britain will be Mr. John Dunville and Mr. Jean de Francia. On the Saturday previous to the race, the delegates from the various countries will visit the various aerodromes around Paris. Members of the Royal Aero Club wishing to visit Paris for the race are requested to send their names to the Secretary. 166, Piccadilly, W. HAROLD E. PERRIN, Secretary. 1039
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Identity Card
Type: short Alcoholic level: alcoholic Basic liqueur: Tia Maria Equipment: shaker Glassware: double cocktail glass Garnish: undecorated
- 3/5 Tia Maria
- 2/5 Crème de cacao
- 2 tablespoons cream (single or light)
How to make itPlace some ice cubes in the shaker and add Tia Maria and Crème de cacao. Shake for 6-8 seconds and strain into the glass. Spoon the cream but be careful not to mix it with the other ingredients. The cocktail is ready.
Variations and note
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You are a motivated, flexible, and a passionate team player? You want to learn more about event management? Then you might be the perfect match for our team. During the Indian Film Festival taking place from the 18th to 22nd July 2017 in Stuttgart we offer the chance for unpaid internships in several organizational fields:
Interested? Please complete and return the application form with your digital photo, a copy of your passport and a copy of your driver's license (if applicable) to:
Filmbüro Baden-Württemberg e.V.
Friedrichstr. 37
70174 Stuttgart
Fon: +49 (0)711 - 22 10 67
Fax: +49 (0)711 - 22 10 69


text:
From John Ray's shorter notes
July 21, 2017
Arabian gold
Did you know that they mine gold in Saudi Arabia? I didn't but I should have. There are over 400 mentions of gold in the Bible so it had to come from somewhere. And Arabia is right next door. But as far as I can find the only mention of gold's origin is in Genesis 2:
"And a river went out of Eden to water the garden; and from thence it was parted, and became into four heads. The name of the first is Pison: that is it which compaseth the whole land of Havilah, where there is gold".
Archaeologists have recently identified where the ancient river Pishon flowed. And it is roughly in the middle of Arabia.
A few excerpts about modern gold mining in Saudi Arabia:
State-controlled mining firm Saudi Ma'aden plans to develop the Mansourah, Massarah gold mine, industry sources told Reuters.
Ma'aden operates six gold mines in the Central Arabian Gold Region, western Saudi Arabia which contains much of the Kingdom's gold rich ore deposits. It has recently started operating the Ad Duwayhi gold mine.
Saudi Arabia's efforts to build an economy that does not rely on oil and state subsidies involves a shift towards mining vast untapped reserves of bauxite, the main source of aluminium, as well as phosphate, gold, copper and uranium.
Go to John Ray's Main academic menu
Go to Menu of longer writings
Go to John Ray's basic home page
Go to John Ray's pictorial Home Page
Go to Selected pictures from John Ray's blogs


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The New York Times on Monday reported that Mayor Michael Bloomberg "some months ago" had asked Secretary of State Hillary Clinton to consider running for mayor in 2013. The former first lady, who plans to leave her post in the Obama administration, "left little room for doubt: she was not interested in seeking the mayoralty," the Times wrote. The phone call suggests that the mayor, like many in the business community, is ambivalent about the field of likely candidates: liberal career politicians or little-known, poorly financed outsiders.
Would you vote for Hillary Clinton for mayor?
15 Responses
I'd rather see Bill as Mayor although I'm sure Hillary is more than qualified. Too bad there isn't anyone considering running worth voting for. I'd probably be as good a candidate — US Navy veteran, native New Yorker, head of a family business here for over 30 years that has brought thousands of people to NYC, etc., etc. — than those who already have their hats in the ring. Maybe I should start a PAC.
Vote for robbo!
Please explain how she's "more than qualified." What has she ever successfully managed? And please don't say the State Department because that's in shambles.
Bill & Hillary still live in Chappaqua, don't they?
Thank you, Robert!
They do but when has that stopped her (e.g. being Senator from NY and never living here)?
Good heavens! Will these people never go away???? No. I will not vote for her. Go back to wherever you people came from already!!!!
When will we be rid of the Clintons?
I'm still betting that she will run for President. And Bill will be the nations First Man. He and she'll do anything to get back in the Whitehouse, anything.
The feeling of entitlement these two have is just stunning…
The greatest thing to ever happen to Bill's life will be if Hillary becomes President.
This way, Bill can chase all the trim he wants in the West Wing, without any little distractions like running the country getting in the way.
Chelsea for Mayor!
Hillary Clinton for dog catcher!
It certainly says a lot about the quality (or lack of) among the current crop of possible mayoral candidates that we arebe considering a possible candidate to run the city, qualified in skills, but not in residency . With all his faults, Bloomberg has left a very high standard for the next Mayor. Are there any other civic minded billionaires out there who would like to run?
What skills? What has she ever successfully managed?
Please, she's not the least bit qualified to run this city. She's never had a real job before being a Senator, which is not an executive or administrative job. She supposedly runs the State Department now but look what a mess she's left of that and our country's standing throughout the world. The world is now in turmoil mostly because the US, under Obama, is perceived as being weak and Hillary has done nothing to fix this. So, no she's not qualified to run this city which is probably a tougher job than being President. Bill Kelly would be the best choice for Mayor but he'll never win because only a Democrat will be elected in this stupid city.


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Seabirds-and-SealsShetland Category Nature & Wildlife
Shetland's award winning wildlife adventure cruises around Noss National Nature Reserve and Bressay depart seven days a week from Victoria Pier Slipway, Lerwick at 10am and 2pm.
Visit Britain's best bird cliffs aboard Shetland's top wildlife tour boat, Dunter III.
Sail with our expert local guides to meet birds and seals at amazingly close range. Marvel at the stupendous cliffs, stacks, coves and caves. PLUS the unique Shetland Submarine - every cruise includes underwater viewing with remotely-controlled video cameras, to reveal the teeming sea-life in the caves and kelp forests below the waves. See the entire food chain from tiny plankton to gannets and grey seals.
You'll be amazed how close we can take you to the 20,000 Gannets, 30,000 Guillemots and hundreds of Puffins, Razor bills, Black Guillemots, Kittiwakes, Shags and Skuas, not to mention the breath taking cliffs, caves and stacks. Most days we get to very close to seals and sometimes there are porpoises or whales if any are in the area at the time - Every trip is different and you never know what you might see!
We have a heated salon with panoramic views but the best views are from our open deck and the observation platform upstairs, so please wear warm clothing. There are even binoculars to borrow in case you forget to take your own.
Wheelchair users are welcome as our main deck and toilet compartment on the Dunter III are accessible for wheelchair users.
(via Visit Scotland)


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Preschool and Kindergarten
Picture-based learning course for preschool and Kindergarten
Did you like the free lessons at preschool.wordzila.com?
Now you can download the complete course.
Nursery 5 books: Album, Prewriting, English, Workbook, Numbers
Lower Kindergarten 6 books: Album, English, Workbook, Math, Science, Skills Book
Upper Kindergarten 7 books: Album, English, Workbook, Math, Science, Social Studies, Skills Book
Kindergarten B (UKG) Package
zip, 97.4 MB
Kindergarten A (LKG) Package
zip, 52.1 MB
Preschool (Nursery) Package
zip, 34.7 MB
Even as educators worldwide continue to debate the extent to which preschools and kindergartens should teach children such basic skills as phonics, reading, and arithmetic, we at Wordzila have devised our own system based on what best suits our kids back home. In the process, we have gleaned leniently from the internationally practiced Early Childhood Education System and other appropriate kindergarten curriculums. Our programme thus includes skills and concepts that have been identified by experts globally as vital to preschool and kindergarten age-group children. Ample attention is given to creative and selfexpressive activities while preparing the children for school readiness.
Download now or go back to our free online lessons.


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Mostly because she can quickly do this! It makes me laugh to see how deliberate she is about twisting her little body around to roll over.
Aubrey is starting to figure out that she can actually get places by rolling around. She isn't very fast yet, but I am sure she will figure it out before long!
Guess I'd better start childproofing the house again!


text: Fine dining isn't something you find easily at the falls, which makes this fine restaurant at the Sterling Inn & Spa so refreshing. Service, decor, presentation and especially the quality of the food all rate highly. It has a seasonal menu featuring dishes like fennel pollen pickerel, roasted venison loin and crispy skinned trout, sourced locally.


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Frequent Links
Nav1.7 is a sodium ion channel that in humans is encoded by the SCN9A gene.[1][2][3] It is usually expressed at high levels in two types of neurons, the nociceptive (pain) neurons at dorsal root ganglion (DRG) and trigeminal ganglion, and sympathetic ganglion neurons, which are part of the autonomic (involuntary) nervous system.[4][5]
Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Nav1.7 is present at the endings of pain-sensing nerves, the nociceptors, close to region where the impulse is initiated. Stimulation of the nociceptor nerve endings produces "generator potentials", which is small changes in the voltage across the neuronal membranes. The Nav1.7 channel amplifies these membrane depolarizations, and when the membrane potential difference reaches a specific threshold, the neuron fires. In sensory neurons, multiple voltage-dependent sodium currents can be differentiated by their voltage dependence and by sensitivity to the voltage-gated sodium-channel blocker tetrodotoxin. The Nav1.7 channel produces a rapidly activating and inactivating current which is sensitive to level of tetrodotoxin.[6] Nav1.7 is important in early phases of neuronal electrogenesis. Nav1.7 is described by slow transition of the channel into an inactive state when it is depolarized, even to a minor degree. This property that allows these channels to remain available for activation with even small or slowly developing depolarizations. Stimulation of the nociceptor nerve endings produces "generator potentials", which is small changes in the voltage across the neuronal membranes. This brings neurons to certain voltage that stimulate Nav1.8, which has a more depolarized activation threshold that produces most of the transmembrane current responsible for the depolarizing phase of action potentials.
Clinical significance
Animal studies
The critical role of Nav1.7 in nociception and pain was originally shown using Cre-Lox recombination tissue specific knockout mice. These transgenic mice specifically lack Nav1.7 in Nav1.8 positive nociceptors and showed reduced behavioural responses, specifically to acute mechanical and inflammatory pain assays. At the same time, behavioural responses to acute thermal and neuropathic pain assays remained intact.[7] However, the expression of Nav1.7 is not restricted to Nav1.8 positive DRG neurons. Further work examining the behavioural response of two other transgenic mouse strains; one lacking Nav1.7 in all DRG neurons and the another lacking Nav1.7 in all DRG neurons as well as all sympathetic neurons, has revealed distinct sets of modality specific peripheral neurons.[8] Therefore Nav1.7 expressed in Nav1.8 positive DRG neurons is critical for normal responses to acute mechanical and inflammatory pain assays. Whilst Nav1.7 expressed in Nav1.8 negative DRG neurons is critical for normal responses to acute thermal pain assays. Finally, Nav1.7 expressed in sympathetic neurons is critical for normal behavioural responses to neuropathic pain assays.
Primary erythromelalgia
Mutation in Nav1.7 may result in primary erythromelalgia (PE), an autosomal dominant, inherited disorder which is characterized by attacks or episodes of symmetrical burning pain of the feet, lower legs, and sometimes hands, elevated skin temperature of affected areas, and reddened extremities. The mutation causes excessive channel activity which suggests that Nav1.7 sets the gain on pain signaling in humans. It was observed that a missense mutation in the SCN9A gene affected conserved residues in the pore-forming α subunit of the Nav1.7 channel. Many studies have found a dozen SCN9A mutations in multiple families as causing erythromelagia. All of the observed erythromelalgia mutations that are observed are missense mutations that change important and highly conserved amino acid residues of the Nav1.7 protein. The majority of mutations that cause PE are located in cytoplasmic linkers of the Nav1.7 channel, however some mutations are present in transmembrane domains of the channel. The PE mutations cause a hyperpolarizing shift in the voltage dependence of channel activation, which allows the channel to be activated by smaller than normal depolarizations, thus enhancing the activity of Nav1.7. Moreover, the majority of the PE mutations also slow deactivation, thus keeping the channel open longer once it is activated.[9] In addition, in response to a slow, depolarizing stimulus, most mutant channels will generate a larger than normal sodium current. Each of these alterations in activation and deactivation can contribute to the hyperexcitability of pain-signaling DRG neurons expressing these mutant channels, thus causing extreme sensitivity to pain hyperalgesia. While the expression of PE Nav1.7 mutations produces hyperexcitability in DRG neurons, studies on cultured rat in sympathetic ganglion neurons indicate that expression of these same PE mutations results in reduction of excitability of these cells. This occurs because Nav1.8 channels, which are selectively expressed in addition to Nav1.7 in DRG neurons, are not present within sympathetic ganglion neurons. Thus lack of Nav1.7 results in inactivation of the sodium channels results in reduced excitability. Thus physiological interaction of Nav1.7 and Nav1.8 can explain the reason that PE presents with pain due to hyperexcitability of nociceptors and with sympathetic dysfunction that is most likely due to hypoexcitability of sympathetic ganglion neurons.[5] Recent studies have associated a defect in SCN9A with congenital insensitivity to pain.[10]
Paroxysmal extreme pain disorder
Paroxysmal extreme pain disorder (PEPD) is another rare, extreme pain disorder.[11][12] Like primary erythromelalgia, PEPD is similarly the result of a gain-of-function mutation in the gene encoding the Nav1.7 channel.[11][12]
|This section requires expansion. (July 2014)
Congenital insensitivity to pain
Individuals with congenital insensitivity to pain have painless injuries beginning in infancy but otherwise normal sensory responses upon examination. Patients frequently have bruises and cuts, and are often only diagnosed because of limping or lack of use of a limb. Individuals have been reported to be able to walk over burning coals and to insert knives and drive spikes through their arms. It has been observed that the insensitivity to pain does not appear to be due to axonal degeneration.
A mutation that caused loss of Nav1.7 function has been detected in three consanguineous families from northern Pakistan. All mutation observed were nonsense mutation with majority of affected patients having homozygous mutation in the SCN9A gene. Their observation linked loss of Nav1.7 function with incapability to experience pain. The result was in contrast with the genetic basis of primary erythromelalgia in which the disorder results from gain-of-function mutations.[10]
Clinical analgesics
Local anesthetics such as lidocaine mediate their analgesic effects by non-selectively blocking voltage-gated sodium channels.[13][14] Nav1.7, as well as Nav1.3, Nav1.8, and Nav1.9, are the specific channels that have been implicated in pain signaling.[13][15] Thus, the blockade of these specific channels is likely to underlie the analgesia of local anesthetics.[13] In addition, inhibition of these channels is also likely responsible for the analgesic efficacy of certain anticonvulsants, as well as, in part, that of certain tricyclic antidepressants.[16]
Future prospects
As the Nav1.7 channel appears to be a highly important component in nociception, with null activity conferring total analgesia,[12] there has been immense interest in developing selective Nav1.7 channel blockers as potential novel analgesics.[17] Since Nav1.7 is not present in heart tissue or the central nervous system, selective blockers of Nav1.7 – unlike non-selective blockers such as local anesthetics – could be safely used systemically for pain relief. Moreover, selective Nav1.7 blockers may prove to be far more effective analgesics – and without side effects – relative to current pharmacotherapies.[17][18][19]
A number of selective Nav1.7 (and/or Nav1.8) blockers are in clinical development, including CNV1014802, TV-45070 (formerly XEN402), PF-05089771, PF-04531083, DSP-2230, AZD-3161, NKTR-171, GDC-0276, and RG7893 (formerly GDC-0287).[20][21][22] Ralfinamide (formerly NW-1029, FCE-26742A, and PNU-0154339E) is a multimodal, non-selective Nav channel blocker which is under development for the treatment of pain.[23]
- ^ Klugbauer N, Lacinova L, Flockerzi V, Hofmann F (March 1995). "Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells". The EMBO Journal 14 (6): 1084–90. PMC 398185. PMID 7720699.
- ^ Plummer NW, Meisler MH (April 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics 57 (2): 323–31. PMID 10198179. doi:10.1006/geno.1998.5735.
- ^ Catterall WA, Goldin AL, Waxman SG (December 2005). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels". Pharmacological Reviews 57 (4): 397–409. PMID 16382098. doi:10.1124/pr.57.4.4.
- ^ Raymond CK, Castle J, Garrett-Engele P, Armour CD, Kan Z, Tsinoremas N et al. (October 2004). "Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia". The Journal of Biological Chemistry 279 (44): 46234–41. PMID 15302875. doi:10.1074/jbc.M406387200.
- ^ a b Rush AM, Dib-Hajj SD, Liu S, Cummins TR, Black JA, Waxman SG (May 2006). "A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons". Proceedings of the National Academy of Sciences of the United States of America 103 (21): 8245–50. PMC 1472458. PMID 16702558. doi:10.1073/pnas.0602813103.
- ^ Catterall WA (2000). "Structure and regulation of voltage-gated Ca2+ channels". Annual Review of Cell and Developmental Biology 16: 521–55. PMID 11031246. doi:10.1146/annurev.cellbio.16.1.521.
- ^ Nassar MA, Stirling LC, Forlani G, Baker MD, Matthews EA, Dickenson AH et al. (August 2004). "Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain". Proceedings of the National Academy of Sciences of the United States of America 101 (34): 12706–11. PMC 515119. PMID 15314237. doi:10.1073/pnas.0404915101.
- ^ Minett MS, Nassar MA, Clark AK, Passmore G, Dickenson AH, Wang F et al. (April 2012). "Distinct nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons". Nature Communications 3 (4): 791–799. PMC 3337979. PMID 22531176. doi:10.1038/ncomms1795.
- ^ Drenth JP, Michiels JJ (June 1994). "Erythromelalgia and erythermalgia: diagnostic differentiation". International Journal of Dermatology 33 (6): 393–7. PMID 8056469. doi:10.1111/j.1365-4362.1994.tb04037.x.
- ^ a b Cox JJ, Reimann F, Nicholas AK, Thornton G, Roberts E, Springell K et al. (2006). "An SCN9A channelopathy causes congenital inability to experience pain". Nature 444 (7121): 894–8. PMID 17167479. doi:10.1038/nature05413.
- ^ a b Allerton C, Fox D (2013). Pain Therapeutics: Current and Future Treatment Paradigms. Royal Society of Chemistry. pp. 146–148. ISBN 978-1-84973-645-9.
- ^ a b c Kew JN, Davies CH (2010). Ion Channels: From Structure to Function. Oxford University Press. pp. 153–154. ISBN 978-0-19-929675-0.
- ^ a b c Mashour GA, Lydic R (7 September 2011). Neuroscientific Foundations of Anesthesiology. Oxford University Press. p. 154. ISBN 978-0-19-987546-7.
- ^ Mohamed Chahine. Recent advances in voltage-gated sodium channels, their pharmacology and related diseases. Frontiers E-books. p. 90. ISBN 978-2-88919-128-4.
- ^ Lamberth C, Dinges J (9 August 2012). Bioactive Heterocyclic Compound Classes: Pharmaceuticals. John Wiley & Sons. p. 127. ISBN 978-3-527-66448-1.
- ^ Cairns BE (1 September 2009). Peripheral Receptor Targets for Analgesia: Novel Approaches to Pain Management. John Wiley & Sons. pp. 66–68. ISBN 978-0-470-52221-9.
- ^ a b Altman RB, Flockhart D, Goldstein DB (23 January 2012). Principles of Pharmacogenetics and Pharmacogenomics. Cambridge University Press. p. 224. ISBN 978-1-107-37747-9.
- ^ Waxman SG (December 2006). "Neurobiology: a channel sets the gain on pain". Nature 444 (7121): 831–2. PMID 17167466. doi:10.1038/444831a.
- ^ Dib-Hajj SD, Cummins TR, Black JA, Waxman SG (November 2007). "From genes to pain: Nav1.7 and human pain disorders". Trends in Neurosciences 30 (11): 555–63. PMID 17950472. doi:10.1016/j.tins.2007.08.004.
- ^ Bagal SK, Chapman ML, Marron BE, Prime R, Storer RI, Swain NA (2014). "Recent progress in sodium channel modulators for pain". Bioorganic & Medicinal Chemistry Letters. PMID 25060923. doi:10.1016/j.bmcl.2014.06.038.
- ^ Martz L (2014). "Nav-i-gating antibodies for pain". Science-Business eXchange 7 (23). ISSN 1945-3477. doi:10.1038/scibx.2014.662.
- ^ McMahon S, Koltzenburg M, Tracey I, Turk DC (1 March 2013). Wall & Melzack's Textbook of Pain: Expert Consult - Online. Elsevier Health Sciences. p. 508. ISBN 0-7020-5374-0.
- ^ Simpson DM, McArthur JC, Dworkin RH (21 June 2012). Neuropathic Pain: Mechanisms, Diagnosis and Treatment. Oxford University Press. pp. 40–. ISBN 978-0-19-539470-2.
External links
- SCN9A protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- GeneReviews/NCBI/NIH/UW entry on SCN9A-Related Inherited Erythromelalgia


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Applus+ Radiation Protection Services: Subsea Environmental's challenge
Applus+ were approached by Subsea Environmental Services to provide support in the recycling of potentially radioactive telecommunications materials.
Applus+ were approached by Subsea Environmental Services to provide support in the recycling of potentially radioactive telecommunications materials.
In the previous post we reviewed the main technological solutions to secure mobile applications. Depending on the security solution (chip-based, cloud-based or TEE-based) and the target market, chip manufacturers and software developers can choose between various certification schemes applicable to their product. Certification is not legally mandatory but could be an industry requirement to be [...]
As new high-value markets like payments and ID are going mobile, security concerns are increasing. Are smartphones secure enough to be used as a substitute for payment cards? Are phones and tablets a suitable platform to distribute premium content without increasing the risk of piracy? Over the last few years, the payments industry has contributed [...]
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|This is the article on the release based on physical energy that governs life. For the combination of the earth and fire natures, head to Yōton.
Yang Release (陽遁, Yōton, Viz: Light Style)[1] is one of the two nature transformations that exist outside of the elemental circle, along with Yin Release. It is based on the physical energy that governs vitality and is created by altering the ratio of spiritual and physical energy in favour of the latter.
Yang Release can breathe life into form. When combined with Yin Release, it allows for the use of Yin–Yang Release.[2] Yang is depicted as white in the manga and blue in the anime. The Six Paths Yang Power is represented by a sun marking on the wielder's right palm.
Yang was first mentioned in name by Yamato during Naruto Uzumaki's nature transformation training.[3] The Akimichi clan's Multi-Size Technique falls under Yang Release. Being descendants of the Sage of Six Paths through his younger son, the Senju clan predominantly inherited Yang Release.
Yang chakra is also part of the tailed beasts' chakra. During the Nine-Tails' attack on Konoha, Minato Namikaze used the Eight Trigrams Sealing Style to seal the Yang half of the fox's chakra within Naruto.[4] Whenever Naruto is in Nine-Tails Chakra Mode, Wood Release techniques react to the Yang chakra's vitalising properties and mature into full-grown trees within a matter of seconds, either through contact or close proximity.[5] This was also shown to have the same effect on White Zetsu, whose genetic make-up is similar to that of plants.[6]
- Yang Release shares the same romanisation as Lava Release.
- Although not explicitely stated to be Yang Release, techniques like Four Red Yang Formation and Six Red Yang Formation are connected to physical energy and Yang by name.


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12.16.11 Almost 16 months old
Life sure is busy with an active toddler. We've been spending a lot of time at various parks, despite the finally-seasonally-cold weather, because too much time inside leads to all sorts of crazy. (Speaking of cold weather, does anyone have experience with a stroller bunting that works well in the UppaBaby Vista? I bought the toddler size of the JJ Cole Arctic BundleMe that I LOVED when he was an infant, but it's too bulky and doesn't stay in the stroller well at all.)
Tuck is really into throwing and kicking balls, so we always have a ball or two in the stroller and we visit the library lawn almost every day. He's also *obsessed* with his truck books, and carries them with him everywhere. He spends a good part of every day going through his truck and transportation books and pointing at the photos, yelling his version of the name (mostly "BAA!" "CAA!" "TRRR!"). He will crawl into any trusted adult's lap and demand that they read with him, and when left to his own devices he nearly always chooses to unpack the bookcase rather than play with toys. This librarian's daughter is very proud. He does love Ben's cell phone very, very much, and still uses everything as a phone—cars, books, remotes, shoes. Today at the library he got up in a chair and started typing with one hand while "talking" on the mouse with the other.
Over the last couple weeks it seems like Tuck's sense of humor has really shifted into high gear, and with it his understanding of other people's reactions. He does silly things and watches for our reactions, and when he's bad he immediately offers a kiss, knowing that will make us smile and forget that we were mad. Speaking of kisses, he's also really into hugging and kissing other kids right now, but won't really acknowledge most adults. He's finally giving us real hugs though, wrapping his arms around our shoulders. He reaches up from his high chair for hugs during meals—I thought he was saying he wanted to get down, at first!
I don't think I'd mentioned pacifiers in quite a while, but since he was two months old Tuck always slept with one. (We were big fans of the Mam line. We were pretty strict about not allowing them when he was awake after he was eight or 10 months old, so they were firmly part of the bed routine. But recently he started getting really emotional about them—pointing at the shelf where they normally stayed during the day and screaming; holding onto them when he woke up and refusing to give them up, and, worst of all, waking up multiple times each night sobbing until we went into find one and give it back to him. At first he was sick, so we blamed that, and then he was teething, and then sick again, and we were traveling...finally, though, we had to come to grips with the fact that the pacifier was becoming a problem.
Sunday night we went for it. Ben had a long chat with him about how pacifiers are for babies and he's too big now, and I cut the tip off of one and offered him that, explaining that the only pacifier left was broken. He spit it out, then threw it. We put him to bed with his faithful friend Ned, and retreated to the dining room for a miserable half hour while he yelled. He fell asleep eventually, though, and slept until 5:50, then screamed until I went in and got him at 6:50. (He normally sleeps until 7, though he'd been waking up at 3 and 5 and sometimes 6 for the pacifier.) Monday night he only cried for a couple minutes, and he slept until 5:08, cried for maybe a minute, then fell back asleep until 7:15! Tuesday I was putting him to bed because Ben was at a work event, and he started screaming as soon as he was in his sleep sack, with Ned, and realized the pacifier still wasn't coming back. We couldn't even read stories—he kept pointing at the bookcase, so I pulled out book after book, but I think he was gesturing for a pacifier. Eventually I recited Jamberry to him without the book and put him down. He only cried for a couple minutes, and again, he woke briefly around 5, then slept until 7:30. Today at nap it was the same with the books—I hope that part sorts out soon—but he fell asleep quickly and seems to be more solidly asleep than he had been recently. It hasn't been fun but I'm relieved to be dealing with this now.
My big puzzle is what to put in a stocking for a 16-month-old? For gifts we've stuck pretty close to that guideline "something you want, something you need, something to wear, something to read," which helps avoid going overboard with presents. But stockings are a big part of Christmas in my family, always packed with cool stuff (fancy chocolate, art supplies, a new pair of smart wool socks, great little games or gadgets, and always a satsuma mandarin in the toe). I got one little car for Tuck, and my mom sent socks, but I can't think of much else. I'll go to the local toystore this weekend in search of a few things—maybe a little backhoe and a toy dog, and I'll fill the rest with snack stuff he'd have anyway!
(BTW, don't think I didn't notice that my pictures are all the back of his head suddenly! He's always running away.)
Note: Unfortunately spam in the blog comments got out of control, so if you have something you'd like to discuss please shoot me an email (email@example.com) and I'll do my best to respond. I miss hearing from you! I'm also on Twitter: @kateflaim
Kate Flaim is a freelance journalist and food blogger based in Cambridge, Massachusetts.


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If you follow me on social media, I've talked a little bit about the fact that I'm launching a new thing. If you read the blog, you'll also realize that the focus of the new thing isn't really new.
I write about the indie lingerie world a lot. I work with indie designers frequently. I'm buddies with lots of really cool indie designers. I did a whole campaign to convince everyone that indie made to measure lingerie was for them last year. So the fact that I'm launching some full service copywriting programs for independent lingerie designers and independent boutiques shouldn't really be a surprise to anyone.
But, before I do, I'm going to take this week to talk about the value of indies from both a consumer, industry and business perspective. I'm going to talk about what great copywriting can do for indie business owners and why they don't tend to hire copywriters as much as big companies do (it's related to much more than budget, actually). Basically if you're interested in the business side of indie lingerie, this is a week full of awesome content for you. If you're here because you want to see more pretty bras, we'll be back to that next week with a review of the Rita Bra by Elomi.
I'll be releasing the details of the Indie Garden Club on Friday, but if you're interested in more information you can go ahead and sign up for the mailing list now. I won't be doing much selling off of it: it's simply designed to be a place where independent lingerie designers, brands and boutiques can get marketing tips and useful information. It will be fun, friendly and have lots of pretty graphics.
Sign Up for the Indie Garden Club List Here:


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Found 3 of 112 Listings, << Page 1 of 1 >>
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Gorgeous Residence For Sale In Commercial Area
Price US:
San Pedro De Montes De Oca, San José
Land Size:
681 Sq M/ 7330.2 Sq Ft
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Prop ID:
Pre 100
Ample and beautiful house for sale located in San Pedro, near important commercial areas and several Universities ideal to make a bed & breakfast or a small apartotel.
The house has 8 bedrooms, 6 baths, 3 kitchen areas, 5 living room, 2 dining room, 1 terrace, 1 laundry area, 3 garages and garden.
This is your investment opportunity
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Hot Springs Near Rincon De La Vieja Volcano
$ 2,300,000
Northern Pacific
25 Ha / 61.75 Acres
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Explore the incredibly rich biodiversity of the surrounding area where many year round waterfalls and rivers can be found or enjoy a mud bath in the nearby thermal waters while staying at Thermales Azules.
This rustically styled restaurant with cabins lies in a Jungle setting at the bottom of the one biggest Volcano.
Opportunity Coffee Shop For Sale
$ 12,000
San José
Pre 51
This fully equipped Coffee Shop is located into a shopping center in a big and development commercial area, in our capital city.
Turn key and ready to go with all of the equipment to run an up scale Cafe, this business comes with all of the permits including the lease agreement
Inventory along with the sale includes 5 tables with chairs, a display case, Coffee machine, electronic cash register, refrigerator, freezer, commercial dish washer, commercial stove top, assorted lamps and fans, utensils, and all the equipment youll need to start up.
If you are looking to own a business in Costa Rica now would be your chance, so give our office a call and we will be happy to show you this neat little opportunity.
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text:
Nelson (Rocket Men: The Epic Story of the First Men on the Moon, 2009, etc.) returns with a survey of mankind's use of radioactive materials.
Beginning with the discovery of X-rays in 1895 and ending with the disaster at the Fukushima nuclear power plant, the author examines the discovery of radium (used for a while in everything from watches to toothpaste), the development of nuclear fission and fusion, and the use of the resulting new elements in nuclear weapons, medicine and power generation. Nelson's coverage of the science underlying this saga is admirably thorough and accessible, but this is no impersonal "march of science" story. The author also shows how the development of nuclear physics was deeply influenced by contemporary politics and the interplay of the personalities involved. He includes lively biographies of the men—Wilhelm Roentgen, Enrico Fermi, Leo Szilard and others—who created this new age and of two remarkable women: the celebrated Polish-born Marie Curie and the almost forgotten Austrian Lise Meitner. Nelson characterizes nuclear science as a "two-faced god," a blessing and a curse, and its history as irrational, confusing and conflicted. For example, nuclear weapons are so dreadful that they have effectively prevented war between superpowers, but their production and maintenance have been a staggering waste of resources. The author's gripping narratives of the meltdowns at Chernobyl and Fukushima simply scream that fallible humans should not be messing around with this technology, and yet he argues that nuclear power is still the safest and best option for environmentally responsible power generation. Nevertheless, Nelson contends that the nuclear era is now drawing to a close, as the acquisition of nuclear weapons is viewed only as the mark of a pariah regime, and the dishonesty of governments and industry has ruined the prospects for further development of nuclear power.
An engaging history that raises provocative questions about the future of nuclear science.


text:
I'm going to use this post to checkpoint some of my recent research. I realized the other day that I don't know any practical motivations for this work, so I'm going to summarize it in this post and seek feedback regarding its worthwhileness.
Rosetta is a specification language with full-spectrum dependent types and first-class records. This turns out to not play very well with a particular mechanism of import or opening construct we are hoping to support in Rosetta.
The syntax for the import mechanism we're after is
use t1
in t2. In-house, we call it a
use-expression. Such a term is well-formed if the term t1 is a well-formed term denoting a record and the term t2 is well-formed if the fields exported by t1 are in scope as variables. Thus we say that a
use-expression binds the fields of t1 in t2.
In more general vocabulary, I characterize
use-expressions as an implicit import mechanism in order to emphasize the fact that the names it brings into scope do not themselves occur in its syntax. This is a key distinction: an explicit import mechanism is much simpler to formalize since the names are immediately available.
As a consequence of the dependent-types and the fact that Rosetta is a logic, we have a lot of metavariables in our metatheory. These can arise for a variety of reasons. One example is what Rosetta jargon deems "uninterpreted values": Rosetta declarations can bring a value into scope by specifying its type without specifying its value. So, given the declaration
F :: integer -> type, all the rest of the spec sees is that
F is a type constructor. The value of
F is represented as a metavariable. Furthermore, there's not yet enough information to know anything but the type of an application of
F. Thus, the tools also generate a metavariable for an application of
F. Until more details are available about
F (i.e. it is refined, perhaps via user interaction), all we know about this metavariable is that it is equivalent to the application of
F. The same/an equivalent metavariable represents all applications
F to the same/an equivalent argument.
The Question
I sought to answer the question: What happens when you
use a term that has a metavariable as its type? The essence of the problem is that the names being bound are not immediately available. Since the type of the
used term is just a metavariable, the names of its exported fields are cannot necessarily be determined. This complicates the metatheory, since conventional term representations tacitly assume that names can be resolved (i.e. occurrences can be related to the corresponding declaration) immediately.
I have experimented with various context formers (e.g.
…, using u# = x :: T, … |- … where
u# is a fresh name), typing and term equivalence rules (e.g.
use-bound names become either projections when the name is known or else all name occurrences under a
use-binding become a metavariable that is suitable related to the
used term), restrictions on the well-formedness that would partially simplify the metatheory (e.g. names bound by a
use-clause do/must not eclipse existing names), and term representations (e.g. locally nameless with explicit substitutions). The metatheory either gets pretty complicated — i.e. lots of metavariables everywhere (disclaimer: perhaps its already this complicated in most provers?) — or the restrictions are unnatural for the user (e.g. some kinds of shadowing are ignored:
(let x :: int = 4 in x) == (let x :: integer = 4 in use <x :: bool = True> in x)).
The Rub
I neglected to motivate implicit import mechanisms above. Their major benefit is that they decouple the import site (i.e. the
use-expression) from the interface of the imported record/module (i.e. the definition of the
used value). This decoupling improves modularity in a traditional software engineering way. They're quite similar to Java's
lib.piece.* import mechanism.
There's actually a dual to this benefit that is itself a perhaps more significant drawback: if the
used value is extended with another field, then all import sites will suddenly incur an extra binding that might not have been foreseen — this is akin to unwanted variable capture! This drawback can only be safely ignored when the interface of the imported record/module/library is very stable or standardized. But, in these cases, it's also highly unlikely that the type of the record/module/library would be a metavariable.
Thus the interplay between metavariable types and implicit imports that the research set out to formalize has the two following properties.
- It either complicates the metatheory, such as an explosion of metavariables; or it incurs behavior the unnatural to the user, such as
use-bound bindings not being allowed to eclipse other bindings.
- It doesn't actually arise often in practice: you only tend to import quite stable interfaces — otherwise it's not very beneficial to import, since there's not many names in the interface; or it's not very safe, because of the risk of unintended variable capture.
So, supporting implicit import complicates the language metatheory and it both doesn't really happen that often and is kind of risky to use in the first place. That's why I think it's probably not very motivatable.


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As a Cubs fan and former Wrigleyville resident, I had a great time yesterday watching them celebrate the series win at Wrigly Field. Something that hadn't been done in 100 years. As a DomainSherpa panelist I had a job to do during the game. So when you watch the video next week you'll notice me looking away a few times while I watch the game. I almost yelled out a few times. I stayed around and talked domains for another hour with the guys and actually forgot about the game. Fortunately I didn't miss anything because the game was tied when I was done and I got to see the home runs to take the lead. Domains and the Cubs. A hell of a way to spend the afternoon. Here are today 's names. Click for current prices
GAYJ.com Has value as a Quad but there is a guy named J on Grindr that really wants this one
EBBW.com Good English acronym Quad. At $100 at press time
LCHC.com Two Cs lead this into four figures
ChaoZhi.com A Chinese name and the price it's getting is incredible
HYJL.com Guess the price. Are you within $500. Bet you aren't
839777.com The triple 7 is good for a few K
XFZX.com I love Xs and so do the Chinese. They cost about a grand each
SXKT.com Actually this one has only one X and its just as high
DPBP.com Premium quad with repeating 2 and 4. These get 10-20% more IMO
DMK.co People are telling me that LLL.co are increasing. Getting a good price but not a premium
TNJ.co One more if you want to buy a few
598283.com If you want to start getting in on 6N.coms here is one to get you started
667973.com And one more
Special Domain Shane ONLY Coupon…….. CODE IS DDCDS2015 – Good 30% off Discount Domain Club to get the lowest renewal prices Godaddy offers (DDC)
BJE.io Not exactly sure what LLL.io are going for right now but pretty sure its worth more than the present $1 bid. Actually some recent comps on seller's description
Shelly.com My favorite part of this is the first line of the description. "Very old Baby for sale"
CustomWebDesign.com Great name but seller shows too much reliance on Estibot. Needs a better writeup
Downloads.net Has lost a little value over the last few years but considering it was a six figure name at one point tells you that it still has quite a bit
WPKD.com $800 below minimum value IMO
Domaining.xyz portfolio Big name, probably a big reserve …..but worth watching
EZZZ.com The triple consonants have become the new CVCV. Going for super premium.
LAAA.com Maybe its not just consonants
8888828.com Lots of 8s and gets crazy traffic too
TheWeight.com A ton of uses but probably best for a workout or weightloss site. Big money in both
GVPK.com All premium letters. OK maybe not the V but rising tide takes the Vs with it
DI2.com Don't see a lot of 20 year old CCC.coms
BJKP.com Only 22 bidders of which 4 or 5 are always just tracking bids.
DGFQ.com Another Premium quad with just a few bids
TVtoGo.com Perfect name for some company to use for their mobile viewing app
Lengthy.com My nickname in High School. Or was it PigeonToe? Can't remember
StreamParty.com One bidder. Never been invited but like a LAN party I presume. Or you can stream a party like a periscope party.
StockTipsCenter.com Two bidders. Brokerage firms have great affiliate programs and ad have great CPC. Thus the value
GunDealerWebsites.com Tens of thousands of places sell guns in the US. Help them find out where they are
Have a name at auction and need more exposure? Send me an email. (if you have trouble with the contact form its [email protected] this domain name) I Charge $10 per name per day. We may be able to help. If you have an auction you want to promote, email us for details.*All names chosen by me, Shane . (ie you click through and purchase a name you like) or an occasional paid listing. Everything I say is based on my own research or is opinion. Do your own due diligence. That means look it up yourself if you don't think the stats or my opinion is corrects


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Tag Archives: fly
New Mexico Trout Fly Fishing and the Las Conchas Fire
I can say many people are really sad about the New Mexico Trout Fly Fishing and the Las Conchas Fire here in New Mexico and the long lasting impact it will have on many of our loved outdoor activities (hiking, … Continue reading
How To Use Your Fly Fishing Vest Rod Holder – DFF009
A good friend of mine and I were fishing the San Juan River recently (I had not seen him since high school). He was a bit downstream of me, and I asked for his help to land a nice 17 … Continue reading
East Fork of the Jemez River – DFF008
When you have two sons at ages 5 and 3, their combined energy will overwhelm you. One weekend in December I wanted to go fly fishing, but with 2 little boys in tow it's a bit difficult. So we went … Continue reading
San Juan River Fly Fishing – DFF006
I recently reconnected with a high school classmate from San Ildefonso Pueblo and found out he likes to fly fish just like I do. After talking we planned a trip to both of our favorite place, the San Juan River. … Continue reading
Jemez River Fly Fishing – DFF002
I've always thought the Jemez River below Battleship Rock in New Mexico would be a good place to fly fish for a several reasons. The first reason is it's pretty close to Albuquerque & Santa Fe and does not involve … Continue reading
Tingley Beach Fly Fishing – DFF001
In the past Tingley Beach was not on my list of places to fish, years ago when I knew it, it was a large long pond and it was very heavily fished. If you click on the map button (on … Continue reading


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HEALTH chiefs in the Lothians are being forced to cancel a soaring number of operations – because they have no beds.
More than one in ten elective operations in Lothian was cancelled in September, as rising demand places strain on the region's hospitals.
NHS figures reveal that 600 pre-planned operations were postponed that month, equating to around 20 patients having their procedures cancelled each day.
The number of operations cancelled due to bed shortages has tripled since May, as 84 elective operations were delayed due to a spike in urgent cases.
Scottish Conservative health spokesman Jackson Carlaw said he was concerned that NHS Lothian would not be able to cope with the winter months ahead. He said: "These are unacceptable figures. Not only is a cancelled operation a massive inconvenience but in some cases it could affect a patient's health and wellbeing.
"The winter is due to bring additional challenges for the NHS because when the bad weather hits it is understandable that some operations need to be cancelled. This is a wake-up call for both the SNP and NHS Lothian and hopefully they're prepared for the winter months ahead."
Cancelling operations is regarded as a last resort by NHS bosses as it can have a negative impact on both doctors and patients.
Lothian hospitals are struggling to cope with demand as the Evening News reported last month that waiting times for outpatient treatments have soared to a five-year high.
Ian Ritchie, president of the Royal College of Surgeons of Edinburgh, said: "It is important to point out that almost half of the cancellations were made by the patients.
"However, it is still concerning that so many are being cancelled. Clearly we don't want that number of cancellations.
"We have to hope that these were not made too late so another procedure could be done in their place. Otherwise it is a waste of resources.
"It is well documented that the NHS is struggling with capacity along with changes to health and social care."
The health service is also struggling to combat bed blocking – where patients cannot be discharged due to lack of social care – and staff shortages.
Professor Alex McMahon, director of strategic planning, performance reporting and information at NHS Lothian said: "We apologise to anyone who has had their operation rescheduled. We know that it can cause inconvenience and distress for patients and that is why it is a decision that is never taken lightly.
"There are unavoidable circumstances which mean operations have to be rescheduled including emergency admissions, which obviously have to receive priority, be treated quickly and cannot be planned for. Our winter planning work will help predict demand and boost capacity, with the extension of seven-day services and hospital at home systems.
"We will also continue to work closely with our local authority colleagues to improve patient flow, which will free up beds for our elective patients.
"We also recognise that we have a higher than average number of patients who defer their own operation and over the coming months, we are planning to improve our communications with them to try and reduce that figure."


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When Will Congress Get Serious?/
In case you have been deluding yourself into thinking that Congress may be getting even a little serious in its stewardship of taxpayer money, you need to follow two bills currently making their way through the legislative sausage grinder.
We start with a Senate bill, co-sponsored by Menendez (D) of New Jersey and Isakson (R) of Georgia to modify the National Flood Insurance Program (NFIP). That bill has passed the Senate today by a bipartisan vote of 67-32. NFIP is the program by which the federal government provides subsidized insurance for homeowners in flood zones, most notably on or near the beach. And who own homes on and near the beach? In many cases the richest of the rich. That is why federal subsidies to oceanfront homeowners have been proposed by the Manhattan Contrarian as one of only two nominations for "worst possible public policy." To get an idea who benefits from these things, get a look at Billy Joel's oceanfront estate located at Sagaponack, New York.
NFIP has been around since at least the 60s, and everybody who thought about it knew it was way underpriced, but somehow the big storms missed most of the valuable property until after 2000. Then came the likes Katrina, Rita, and Wilma in 2005, and suddenly NFIP was completely broke and in debt around $20 billion to the Treasury. In an article here from April 2013 in Property Casualty 360, R.J. Lehmann of the R Street Institute estimates that the hole will be more like $30 billion by the time all the claims from Sandy (2012) are paid.
In 2012 Congress pretended it was going to get tough by passing something called the Biggert-Waters Reform Act, which supposedly was going to gradually phase in "full-risk rates" for properties in the program. Here is the government's website on Biggert-Waters. They say that rates for non-primary residences were going to increase 25% per year until "full-risk rates" were achieved. Now that's tough! Of course, primary residences were exempted completely so long as they had been built before the area was designated a flood zone. After all, you wouldn't want to treat those rich homeowners like grown-ups, would you?
Well, in 2013 the first round of the premium increases started to kick in, and Congress may be crumbling like a stale cookie. According to an article in the New York Times online today:
[O]ver the past year, millions of coastal property owners were hit with flood insurance rate increases that sent their premiums soaring up to five or 10 times the previous amounts. As their insurance bills soared and their property values plummeted, homeowners begged lawmakers to block or delay the Biggert-Waters provisions.
And here's the quote from the official Senator of the Plutocracy:
"When this bill passes the House, millions of homeowners across America will breathe a sigh of relief," said Senator Charles E. Schumer, Democrat of New York.
According to the Times article, the basic idea of the Senate bill is to delay the premium increases otherwise coming from Biggert-Waters.
What's really funny is how policy, if really bad enough, can make strange bedfellows out of people who otherwise can't agree on anything. For example, according to this article in Insurance Journal, the Obama White House and OMB are actually opposing the Senate bill:
The OMB said the Administration's preference is that Congress retain the Biggert-Waters Flood Insurance Reform Act because delaying the reforms would add to the $24 billion deficit of the National Flood Insurance Program (NFIP). It urged Congress to find a way instead to target relief to "economically distressed policyholders."
That actually sounds pretty good, although might I be so impolite as to ask exactly how "economically stressed" someone might be when they own a second home at the beach? Meanwhile, others noted as opposing this monstrosity are various environmental groups. Remember, even a stopped clock is right twice a day.
The (maybe) good news is that the prospects for this bill in the House are not that great, and there are actually some serious opponents. To me, this is a litmus test for the Republicans: If they can't stop this one, what's the point?
And to illustrate that further, we have another bill working its way through Congress, and this one has just passed the Republican-controlled House. The vote was 251-166, also bipartisan. It's the $100 billion per year Farm Bill. According to this from the EPA, only about 1.5 million people in the U.S. have farming as their principal occupation -- so this is about $67,000 for each of them per year.
Yes, it's a big goody-bag with handouts for everybody who took the time and effort to stick their hand out. Followers of farm bills know that the game is to combine into one bill vast handouts for farmers and their attendants, to get the rural states, with the food stamp program, to get the urban states. We'll just pass out money to everybody and nobody has to pay!
Fox News has the story on the Farm Bill here, and it couldn't be more disheartening. There are lists of examples of the goodies for everybody, like:
[A] boost in money for crop insurance popular in the Midwest; higher rice and peanut subsidies for Southern farmers; and renewal of federal land payments for Western states.
So has there been any effort at all by anyone to get spending under control? How about those heartless conservatives?
Some House conservatives were not happy with the new bill. They originally wanted to dial back food stamp spending by $4 billion a year; the new bill cuts $800 million a year -- which represents about 1 percent of the $80 billion-a-year program.
So the food stamp program has more than doubled over the past 5 years, from spending $37.6 billion in 2008 to $79.6 billion in 2013, and the heartless conservatives want to try for a big 5% cut back to around $76 billion. And what has been achieved is all of 1%. And even that is just the removal of a single item of transparent fraud, namely a practice of some states of giving some people who don't need it a small heating subsidy which in turn automatically qualifies them for food stamps even though they do not meet income and asset criteria. Frankly, this is pathetic.


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If you have gone to Funky Sole, LA's finest weekly raw funky soul party, you have seen Music Man Miles providing killer funk sounds every Saturday at The Echo. Miles Tackett is also distinguished as a member of the funk band Breakestra with his characteristic vocals and guitar skills. For over a decade in the Los Angeles underground funk scene it is no surprise that Miles would come up with a solo production influenced by the many paths of his life.
Last week, the Bootleg Theatre hosted a night for all to witness Tackett's new material "The Fool Who Wonders" a soulful funk soul production with dashes of psychedelia, just like this night. Between Miles voice, guitar and visuals accompanied by high caliber musicians, the audience was astound and thoroughly attentive to the performance taking place. Highlight of the night: Miles young family member cheering him "you can do this!" (way cute) which was enhanced by the presence of the afrobeat band Mexico68 providing additional dancing vibes. The hours of rehearsal and meticulous production was certainly noticed one song after the other with fresh sounds that will undoubtedly reach different corners of Los Angeles and beyond.
Below, check Miles recently released video of his song "Just What I Need" to get a little taste of The Fool Who Wonders and for even more photos of the night please visit FARAHSTOP, the music photography archive.


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But Why?
Why do the sardines travel north? Why don't they all do it (this awesome shoal contains only about 2% of the sardines in the area)? Where do they go afterwards? Do they return south? If so, when do they do it?
No-one knows the definitive answers to any of these questions, so one of the Sardine Run Association's objectives is to encourage and enable research that can find them.


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Here are the charts of the day for Monday March 12, 2018.
Broadcom ( AVGO): Shares are getting a boost following a Wall Street Journal oreport that Intel is considering a range of options pertaining to Qualcomm's bid for Broadcom.
Oclaro ( OCLR): Shares soaring in early trading. Laser and optical fibre supplier Lumentum Holdings is going to buy optical company Oclaro for $1.8 billion, in order to broaden its laser product range.
Johnson Controls (JCI): Shares are climbing here. The HVAC and auto supplier announced it is exploring strategic alternatives for its power solutions business, which makes batteries for cars and light trucks.
For more on today's big stock movers check out the Final Round, live at 3:55 p.m. Eastern, right here on Yahoo Finance.


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Home Press Releases Philippine Embassy and Knights of Rizal Remember Jose Rizals Berlin Sojourn
|Philippine Embassy and Knights of Rizal Remember Jose Rizals Berlin Sojourn
|Philippine Embassy and Knights of Rizal Remember Jose Rizals Berlin Sojourn
|Written by Philippine Embassy Webmaster
|Monday, 12 January 2015
Philippine Embassy and Knights of Rizal Remember Jose Rizals Berlin Sojourn
Berlin, 5 January 2015. On 30 December 2014, Philippine Embassy officials and representatives from the Berlin-Brandenburg Chapter of the Order of Knights of Rizal and the Ladies for Rizal braved frigid and snowy conditions to commemorate Jose Rizals 118th death anniversary by laying a wreath at Rizals former residence on 71 Jägerstrasse.
Philippine Embassy staff and representatives from the Knights of Rizal and Ladies for Rizal lay a wreath at Jose Rizals former residence in Berlin.
Mr. Mardomel Melicor, Chargé dAffaires, a.i., recalled that Jose Rizal spent the winter months of 1886 and 1887 here completing his classic Noli me Tangere. For their part, Mr. Gerhard Müller and Mrs. Lourdes Müller, of the Knights of Rizal and Ladies for Rizal, noted that Jose Rizal had a deep knowledge of Germany, having lived and travelled the expanse of the Hohenzollern Empire, including Heidelberg, Wilhemsfeld, Ulm, Munich, Berlin, and Dresden.
Ms. Azela Arumpac, Third Secretary of the Philippine Embassy, also
recalled that Rizal was a frequent visitor at the Universität zu Berlin
and the Königliche Bibliothek (Royal Library). There, he borrowed books
translating Schiller to improve his German. Rizal also read avidly
books on the Philippine islands by German scholars, such as Fedor Jagor,
AB Meyer, and even William von Humboldt, who wrote on the Philippine
language: Tagalog. Rizal found the work of the German scholars on
Philippine ethnography to be scientific, objective, and non-racist. He
was accepted as a member of the Berlin Society for Anthropology,
Ethnology and Pre-History after delivering an inaugural lecture on the
art of Tagalog poetry and verse.
In his correspondence and upon
leaving Europe, Rizal communicated: I always think of Germany and the
German scholars. I always talk of German loyalty and integrity. When I
hear German spoken, I am glad, as if it were my mother tongue
I will
dedicate my last farewell to Germany. I owe Germany my best
remembrances. Today, over 25,000 Filipinos have immigrated to Germany,
and like Rizal, have made it their second home.
|Last Updated ( Tuesday, 21 April 2015 )


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A division bench of Gujarat High Court (HC) comprising of Chief Justice Bhaskar Bhattacharya and Justice J B Pardiwala have issued notices to Gujarat Congress president, Arjun Modhwadia, and others in connection with a public interest litigation (PIL) that has alleged that Modhwadia has encroached upon a public road in Porbandar city.
The PIL has been moved by a resident of Porbandar, Prakash Unadkat. According to the petitioner's lawyer – Pranav Dave, "Modhwadia and his brother, Ramdevbhai, have encroached upon a public road in Porbandar outside their residence by constructing a structure for their personal security personnel. The Chief Officer of Porbandar Nagarpalika had, in November 2013, given them notice to remove the encroachment. However, till date, the authorities have failed to remove the encroachment. And so, we have moved the PIL."
Apart from Modhwadia and his brother, Porbandar Nagarpalika's Chief Officer, Porbandar Collector, Porbandar District Superintendent of Police, Director of Municipalities and Secretary of Revenue Department have been issued notices by the court last week.
The matter is posted for further hearing on February 6.


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Replace the ignitor in an oven by removing the base cover plate, removing the ignitor, connecting the new ignotor and reassembling the oven. Replacement of the electric ignitor in a gas oven is considered an easy project that should take about 15 minutes.
Once you've purchased the correct replacement ignitor, disconnect all electrical power to the oven by unplugging the unit or tripping the breaker on the house's main electrical panel. Make sure the gas is turned off to the supply line feeding the oven. Remove the oven cooking racks. Next remove the two screws holding down the base cover plate, and remove the plate; the screws should be located at the rear of the plate. This exposes the ignitor located on the bottom of the oven towards the back. Remove the two screws from the bracket holding the ignitor in place, unplug its electrical connection, and remove the old ignitor.
Connect the wires of the new ignitor. If the plugs do not match they can be cut off, the wires stripped and spliced together with the ceramic nuts provided. Do not use plastic wire nuts, which are likely to melt and fail during use. Attach the ignitor to the mounting bracket, making sure to situate the carbide electrode in the same position relative to the burner holes as the old part.
Replace the base cover plate, tighten the mounting screws, and reinsert the oven racks. Turn the gas and electricity back on, and test the oven.