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Dr. Bronner's has many various uses around the house. You can wash your body, your beard, your hair, your kids, your dog, your fruits and veggies, your dishes, your carpet, your car, your neighbor's car – you get the picture. The main thing to remember: this is highly concentrated stuff, a little goes a long way! You need to use the appropriate amount (and type) of Dr. B's for the job at hand, otherwise you are wasting this precious and wonderful smelling commodity. The most basic use of Dr. Bronner's is for hand soap. What could possibly be better than plain-old supercharged peppermint magic soap? That's right: foaming supercharged peppermint magic soap! Not only can this foaming magic soap be used at home, it can be used extensively around the campsite! In this post, I'll show you how to make foaming Dr. Bronner's hand soap.
//Begin Rant //
Dr. Bronner's is not promoted, nor should it be, as an "anti-bacterial" soap. This stuff is too good to be labled anything but "magic soap". It is, however, in the "disinfectant" category of soaps. According to my extensive research (not!), and the Bronner family's blogger-mom, Lisa Bronner, anti-bacterial soap kills 99.9% of the "bad stuff" and disinfectant soaps kill 99%. Big whoop. Before the advent of "anti-bacterial" soap, what did we ever do? Lions and tigers and germs, oh my! You don't need "anti-bacterial" to have clean hands. Soap and water people, soap and water. Sure, if you are about to go into surgery or are a dental hygienist, by all means, anti-bacterial is probably preferable for your given trade, but for the average person at home – why subject yourself to even more chemicals that you cant spell, pronounce, or be reasonably sure of the source? I personally have no earthly idea where or what labs sodiom lauryl sulfate or triclosan are concocted in. I can, however, wrap my brain around the origins of coconut, hemp, olive, and other oils/extracts that go into Dr. Bronner's soaps. Call me crazy.
Prior to using Dr. B's exclusively around the house for my hand soap, my hands would become itchy, dry, flaky, and sensitive, especially during the winter months. It didn't dawn on me until I had switched to Dr. B's that the cause of this was the "cleaning" agents in the anti-bacterial soaps. Yep, it was cleaning the skin right off my sensitive little girly guitar playing man-hands. Try bending a G string on the 9th fret with no skin on your knuckles. It really makes guitar playing interesting! But there is hope for you, as there was for me. I 've had two problem free winters now, since using Dr. Bronner's when at all possible. Now, I'm not saying I bust out the Dr. B's at a rest stop, but at home, where the majority of the hand washing gets done, it's the good doctor and nothing else for me. Furthermore, my rate of illness (cold, flu, whatever) has neither increased nor decreased over the past two years. Even more further more (if there can be such a thing), my little Joe used to get rashes and blotchy skin from the "regular" soap we would buy at the store. This condition has disappeared now that he uses Dr. Bronner's 85% of the time for hand washing.
To appease my better half, who is a self-admitted germ-a-phobe, we have been buying "lotion soap" for her (but not anti-bacterial) to use in the kitchen for the past year or so. But, seeing that her family isn't dying a slow and painful death by discontinuing the chemical onslaught, she is slowly converting to Dr. Bronner's for hand soap as well. Recently she has conceded to 100% Dr. B's in the bathrooms, which is big step in the right direction for this ANTI-anti-bacterial dad. //End Rant//
I was going to end this post by giving you instructions on how to make foaming Dr. Bronner's soap, but given the length of the previous tangent, you'll have to wait for part ii.
I promise to stick to the paved road in that one…


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William Reed, 7th-dan in Yuishinkai Aikido
Reed Sensei discovered Aikido in 1963 at the age of 11, in an effort to learn self-defense after being bullied on the way home from school. This led to a lifetime commitment to study and teach Aikido, beginning in 1972 when he spent a year in Japan at university. You can read about in his Manga Bio online
He started Aikido with under Tohei Sensei at Aikikai, which at the time was the only Aikido school in existence. He joined the Ki Society when Tohei Sensei split off in 1974, and studied intensively with Tohei Sensei for close to 30 years, reaching 6th-dan and writing several books during that period, including Ki: A Practical Guide for Westerners, and Ki: A Road that Anyone Can Walk, the most comprehensive biography of Tohei Sensei in English. He joined the Yuishinkai in 2002, and currently holds a 7th-dan from Maruyama Sensei.
Reed Sensei is also certified as an instructor in Nanba: the Japanese Art of Physical Finesse, which he has taught at a Toho Gakuen College of music in Japan, in addition to conducting regular training sessions in Nanba in Japan. Check the Nanba websites in English and http://www.nanbanote.com/
He is completely bilingual in Japanese and English, and has written numerous books in Japanese, including an Amazon Number One bestseller on Mindmapping. He is a prolific writer as a columnist, with several hundred articles in print. You can read his Creative Career Path column online
He is also a Shihan in Shodo, brush calligraphy, and is active as an artist in painting Japanese characters in various media.
His primary websites are at:
Personal Website
EMC Quest
Reed sensei has formed a close relationship with local Aikidoka (and quantum physicist) Dr Anthony Rassmussen who will host Reed Sensei's visit through our dojo.
See Will Sensei's profile

subset: commoncrawl


text: It's been a while since I have had time to sit down and photograph the birds in our garden. Today I put a bit of Bacon fat out and a couple of gulls visited. It is amazing that they totally ignore bread, but the minute I put fat out there, they appear! 🙂


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Labour has called an Opposition Day debate in parliament on 23 May. This "humble address" is to debate [pdf, p6] "outsourcing and privatisation in the NHS".
Outsourcing and privatisation
As The Canary previously reported, there are two important debates timetabled. The debate concerning the NHS will demand papers (including minutes and discussions) from Theresa May's government, to give details about three key areas:
Proposals for reform under the Health and Social Care Act 2012.
Details about proposals for accountable care organisations (ACOs).
Matters relating to any proposed increase of outsourcing and privatisation in the NHS.
https://www.thecanary.co/discovery/news ... f-the-nhs/
Can't be allowed to continue.
The ToryScum must be stopped!


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Anarchy of Senses
Beside this I am also explored the lived (or experienced) time, space and nature, then the mythological and imaginary time, space and nature. Then I dramatically combined and manipulated the results with issues in our contemporary time and every day practice. To achieve that in my artwork, I have to keep the formal structure of practice, beside the outsider uncanny ideas.
In doing so, am giving in to the condition of space and time where an individual or a group of individual reside. This is done through the up lifting of crowded tumultuous images, which has been for a long time, brewing and the reduction of presents with a sharp stroke or a naked line.
My thought here resembles the spark between the viewer and the artwork or that outlet when it comes in contact with an idea, a memory, a familiarity or a twisted reality.
Ghasan Saaid


text: MTHFR Gene Polymorphism-Mutations and Air Pollution as Risk Factors for Breast Cancer: A Metaprediction StudyGonzales, Mildred C.; Yu, Pojui; Shiao, S. Pamela K.Nursing Research: March/April 2017 - Volume 66 - Issue 2 - p 152–163 doi: 10.1097/NNR.0000000000000206 FEATURE ARTICLES Open SDC Abstract Author InformationAuthors Article OutlineOutline Article MetricsMetrics Background The methylenetetrahydrofolate reductase gene (MTHFR) is one of the most investigated genes associated with breast cancer for its role in epigenetic pathways. Objectives The objectives of this metaprediction study were to examine the polymorphism-mutation risk subtypes of MTHFR and air pollution as contributing factors for breast cancer. Methods For triangulation purposes in metapredictive analyses, we used a recursive partition tree, nonlinear association curve fit, and heat maps for data visualization, in addition to the conventional comparison procedure and pooled analyses. Results We included 36,683 breast cancer cases and 40,689 controls across 82 studies for MTHFR 677 and 23,252 cases and 27,094 controls across 50 studies for MTHFR 1298. MTHFR 677 TT was a risk genotype for breast cancer (p = .0004) and in the East Asian subgroup (p = .005). On global maps, the most polymorphism-mutations on MTHFR 677 TT were found in the Middle East, Europe, Asia, and the Americas, whereas the most mutations on MTHFR 1298 CC were located in Europe and the Middle East for the control group. The geographic information system maps further revealed that MTHFR 677 TT mutations yielded a higher risk of breast cancer for Australia, East Asia, the Middle East, South Europe, Morocco, and the Americas and that MTHFR 1298 CC mutations yielded a higher risk in Asia, the Middle East, South Europe, and South America. Metapredictive analysis revealed that air pollution level was significantly associated with MTHFR 677 TT polymorphism-mutation genotype. Discussion We present the most comprehensive analyses to date of MTHFR polymorphism-mutations and breast cancer risk. Future nursing studies are needed to investigate the health impact on breast cancer of epigenetics and air pollution across populations. Mildred C. Gonzales, PhD, RN, OCN, is Nursing Instructor, Los Angeles County College of Nursing and Allied Health, California. Pojui Yu, RN, MSN, is Instructor, School of Nursing and College of Medicine, National Taiwan University, Taipei. S. Pamela K. Shiao, PhD, RN, FAAN, is Associate Dean for Nursing Research, Professor, and E. Louise Grant Endowed Chair, College of Nursing; Graduate Faculty, Graduate School; and Faculty, Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's web site (www.nursingresearchonline.com). Accepted for publication October 27, 2016. The authors have no conflicts of interest to report. Editorial Note: Dr. Jacquelyn Taylor was Action Editor for this paper. Corresponding author: S. Pamela K. Shiao, PhD, RN, FAAN, College of Nursing, Augusta University, 987 St. Sebastian Way, Room EC 4505, Augusta, GA 30912 (e-mail: email@example.com; firstname.lastname@example.com). This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. Abstract Significance and Objectives METHODS Design Included Studies Characteristics of Original Studies Data Synthesis and Analysis RESULTS Pooled Analyses Air Pollution, MTHFR Mutations, and Breast Cancer Risks DISCUSSION CONCLUSION REFERENCES Supplemental Digital Content Breast cancer is the most common malignancy and the second leading cause of cancer death among women (American Cancer Society, 2016). Genome-wide association studies (Zhang, Beeghly-Fadiel, Long, & Zheng, 2011) have shown that the methylenetetrahydrofolate reductase gene (MTHFR) is one of the most investigated genes in breast cancer for its role in epigenetic modification. Using a metapredictive approach, we investigated whether the MTHFR gene polymorphism-mutations and environmental factors such as air pollution could increase the risk of breast cancer susceptibility. DNA methylation, as one of the epigenetic mechanisms affecting the control of gene transcription and expression, has been a specific target of research for cancer treatment and prevention (Eccles et al., 2013). The two most common loci of polymorphism-mutations in the MTHFR gene are C677T (rs1801133) and A1298C (rs1801131), which are both associated with reduced enzymatic activity. Homozygote 677 TT has been associated with approximately 70% loss of enzymatic function, and heterozygote 677 CT with 35% loss of function, compared to homozygote wild-type 677 CC (100% full enzymatic activity; Frosst et al., 1995). Individuals with the 677 TT genotype had significantly elevated homocysteine levels, with a decline in methylation of homocysteine to methionine in the plasma, adversely channeling the homocysteine metabolism into a transsulfuration pathway, leading to toxicities. Thereby, these polymorphism-mutations predispose individuals to multiple disease conditions such as thrombosis, coronary artery disease, myocardial infarction (Mehlig et al., 2013; Yadav et al., 2013), and cancers (Teng et al., 2013; You et al., 2013). Compared to MTHFR 677 mutations, the functional relevance of MTHFR 1298 AC variant is less well defined, and its enzymatic function is less abnormal. MTHFR 1298 CC (homozygote) has been associated with 30% loss of function, and 1298 AC (heterozygote) has 15% loss of function in enzymatic activity compared to 1298 AA wild type (100% full enzymatic activity; Weisberg, Tran, Christensen, Sibani, & Rozen, 1998). MTHFR 1298 mutations are, however, associated with neurotransmitter pathways implicated in multiple neurological disease conditions such as autism, Alzheimer's, Parkinsonism, and in cardiovascular diseases, recurrent miscarriages, and cancers (Pérez-Sepúlveda et al., 2013; Wu, Ding, Sun, Yang, & Sun, 2013; Zidan, Rezk, & Mohammed, 2013). Growing research has focused on interventions aimed at optimizing MTHFR enzymatic function, which can be preventive or therapeutic for multiple disease conditions. The MTHFR enzyme is inactivated by heat (i.e., it is thermolabile). As environmental temperature rises, the MTHFR heterozygous or homozygous mutation state correlates with further reduced enzymatic activity (Frosst et al., 1995). Global warming brought about by air pollution can lead to epigenetic modification critically affecting gene expression (Hoffmann & Willi, 2008); thereby, it may further harm individuals with health problems. Air pollution, causing damage like that from cigarette smoking, has been classified as carcinogenic to humans. Exposure to air pollution in urban settings has been specifically associated with changes in DNA methylation (epigenetic modification), inflammation, immune and oxidative stress response, and gene expression for DNA damage and repair leading to cancer (DeMarini, 2013). Exposure to fine particulate matter (PM2.5) and nitrogen dioxide (NO2), markers of traffic-related air pollution, was associated with the development of breast cancer (Chen & Bina, 2012). Therefore, metapredictive analyses of air pollution on the MTHFR polymorphism-mutations and risk of breast cancer are needed to fill the knowledge gap in understanding the complex interactions of genetics and environment with the development of breast cancer (Figure 1 shows a conceptual framework for the associations of air pollution affecting epigenetic modification and MTHFR gene polymorphisms-mutations, and susceptibility to breast cancer). FIGURE 1 Back to Top | Article Outline Significance and Objectives Previous meta-analyses (Pooja et al., 2015; Xie et al., 2015; Zhong et al., 2014) on the association between MTHFR polymorphisms and breast cancer susceptibility have reported inconclusive results across various racial and ethnic groups. Inconsistent findings could be due to heterogeneity of ethnic heritage, migration, geographic locations, environmental factors, and complex epigenetic pathways leading to carcinogenesis. This study focuses on a significant public health question that many nurses are interested in: Could the mutations associated with breast cancer be associated with levels of air pollution? Answers to this question fill a gap in the literature. Specifically, the authors pose the question as to whether epigenetic modifications in the MTHFR gene have been associated with air pollution in published case–control studies done across the world. The significance of this study is using metapredictive analysis as an applicable method in approaching heterogeneity of previous meta-analysis findings, thus bridging the knowledge gap in the literature (Pereira, Denise, & Lespinet, 2014; Shiao & Yu, 2016). Therefore, the primary objective of this study is to examine the polymorphism-mutation patterns and risk subtypes of MTHFR gene for breast cancer across the globe. The secondary objective is to investigate air pollution as a contributing factor for MTHFR gene polymorphisms and risk for breast cancer through metapredictive analysis. Back to Top | Article Outline METHODS Design This study is a meta-analysis to determine MTHFR gene polymorphism-mutations as risk factors for breast cancer. In addition, to explore the source of heterogeneity from divergent mutation rates of MTHFR polymorphisms and breast cancer risk, metapredictive analytics were used to explore multiple predictors including air pollution for breast cancer susceptibility. For triangulation purpose, geographic information system (GIS) maps, recursive partition analysis, nonlinear association curve fit, and heat maps were used to enhance visualization and representation of data. Back to Top | Article Outline Included Studies Following the guidelines for preferred reporting items for systematic review and meta-analysis (PRISMA; Moher, Liberati, Tetzlaff, Altman, & PRISMA Group, 2009), searches were made using all available databases of PubMed and Airiti Library (leading Chinese e-content provider of academic e-journals) to identify and access all available studies. Search terms used combined breast cancer, MTHFR, environment, and/or air pollution. Without publication date filter, the searches resulted in 168 articles from 1999 (first related study was published) to July 2015 (see Figure 2). For about a year, multiple online searches, three months apart, were conducted to ensure all published studies were found. Previous meta-analyses were reviewed and references were cross-checked to trace all original studies. Abstracts were read and analyzed for their relevance. The inclusion criteria were (a) relevant study of breast cancer and MTHFR, (b) case–control design, (c) clear presentation of genotype allele count data, and (d) detailed quality results of data analysis. Fifty-eight articles were identified as not case–control studies and were excluded. A further 110 articles were retrieved for evaluation. More studies were excluded because they combined various carcinomas and lacked specific data for breast cancer (n = 8), had incomplete and absence of MTHFR genotype allele data and/or data not clearly presented (n = 16), and used duplicate or subsidiary data from other studies (n = 4). Eighty-two articles were finally included in this meta-analysis (see Table S1, Supplemental Digital Content 1, http://links.lww.com/NRES/A215, Characteristics of Studies—Studies Included in the Meta-analysis). Throughout the course of the study, data extraction and entry were conducted and repeatedly checked for accuracy between raters for 100% consensus on the data coding. FIGURE 2 The studies were evaluated for quality using the scoring tool from Shiao and Yu (2016). The tool was developed by integrating sets of criteria adapted from multiple sources on assessment of studies, such as U.S. QUOROM consensus process on the quality of meta-analysis (Moher et al., 1999), quality reporting for observational studies (Stroup et al., 2000), and criteria in related studies (Kennedy et al., 2012; Shiao & Yu, 2016). Utilizing the quality scoring tool, we determined three areas for scoring: (a) external validity, with 10 items on the selection of cases and controls (score range of 0–11); (b) internal validity, with 12 items on genomic research methods and procedure (score range of 0–12); and (c) quality of reporting, with six items on the data and study results (score range of 0–6). The total possible score ranged from 0 to 29. Back to Top | Article Outline Characteristics of Original Studies These 82 studies were conducted across the globe, including Australia, Europe, North and South America, Asia, the Middle East, and Africa. From the 82 studies with MTHFR 677 genotype counts, 50 studies also had 1298 genotype data. Each study was reviewed for race and ethnicity to clearly identify subgroup compositions that could explain possible heterogeneous results. The most investigated racial-ethnic groups for MTHFR and breast cancer were White (28 studies), followed by Asian (25 studies for East Asian and 8 studies for South Asian), Middle Eastern (6 studies), U.S. mixed (8 studies), Brazil mixed (4 studies), Mexico (1 study), Ecuador (1 study), and Morocco (1 study; see Table S1, Supplemental Digital Content 1, http://links.lww.com/NRES/A215, Characteristics of Studies). We also reviewed air quality data globally from the reports of the World Health Organization (2009, 2015). The rates of death from air pollution (APD) were categorized per level in deaths per million population: (a) Level 2 = 100 and under, (b) Level 3 = 101–250, and (c) Level 4 = 251 and above. In each study, we reviewed the frequency distributions of genotype allele counts for MTHFR loci (677 and 1298). They were within the expected distribution ranges per genotype. The control and case groups in the studies were aggregated per country to visualize the bigger picture of genotype percent distribution (see Figure S1, Supplemental Digital Content 2, http://links.lww.com/NRES/A216, MTHFR 677, % Mutations; see Figure S2, Supplemental Digital Content 3, http://links.lww.com/NRES/A217, MTHFR 1298, % Mutations). In each study, DNA samples had been collected from blood, tissue, and buccal swabs or salivary samples and analyzed via established guidelines. The reported accuracy with quality control was 100%, reported in all studies. Using the total score, quality of the studies ranged from 9 to 24 out of a possible 29 points. Of the 82 studies, 15 (18%) were below the 50% mark for the total possible score because of deficient details and missing information required by the criterion for quality scoring. We conducted comparative pooled analyses on all studies with quality scores below 15 and again on those with scores above 15. Outcome results were similar; thus, all studies were included in the meta-analysis. A goodness-of-fit χ2 test was used on all studies to evaluate the Hardy–Weinberg equilibrium (HWE). HWE was suggested to evaluate the distribution of data for the control group populations. Deviations from HWE have been handled in previous reports by meta-analytic approach and by presenting confidence intervals (CI; Ziegler, Steen, & Wellek, 2011). Therefore, we reviewed HWE among controls in all studies and recomputed the results for verification. We considered p < .05 representative of a departure or deviation from HWE. After verifying the reported HWE of the studies, we noted that, in 15 studies, the reports of within-HWE consistency showed discrepancy (deviation from HWE; see Table S1 for HWE status of studies). However, exclusion of these 15 studies did not significantly alter the outcome results; thus, all studies regardless of HWE status were included in the meta-analysis. Back to Top | Article Outline Data Synthesis and Analysis Multiple data sources were merged using applicable statistical programs for analyses. Data were entered using Excel, and StatsDirect version 3.0.158 (StatsDirect, 2015) was used for pooled analyses of risk ratio (RR) and odds ratio (OR), adjusting the weight of sample sizes from each original study. Many previous meta-analyses on this subject used OR. A recognized problem with OR is that, when the outcome is common, the OR may not properly approximate the relative risk (overstatement of the effect size). Thus, there is a danger that OR could exaggerate the relative risk (Viera, 2008). In this study, we preferred RR as it could provide a conservative, standardized ratio and clear understanding on the measure of association. An RR of 1 means "no effect," an RR of <1 indicates a protective effect for breast cancer, and an RR of >1 indicates increased risk of breast cancer; 95% CI was calculated for the comparisons. Significant findings were defined as those with p-values of <.05. Assessment of heterogeneity was performed using Cochran's Q test and I2 to determine whether the differences in results were due to chance. Heterogeneity exists when the Cochran's Q is significant with a p-value of <.10. The I2 statistic is the percentage of variability in the effect estimates due to heterogeneity rather than chance. An I2 statistic value over 50% indicates that substantial heterogeneity may be present (Deeks, Higgins, & Altman, 2011, Section on Identifying and Measuring Heterogeneity section, para. 5). When there was significant heterogeneity, we used a random effects model instead. Conversely, a fixed effects model was chosen when Cochran's Q was not significant, with a p-value of >.10 and I2 value was less than 50% (Deeks et al., 2011, Section on Identifying and Measuring Heterogeneity section, para. 5). A metapredictive method integrates multiple statistical models for triangulation purposes, so it can be more robust and accurate for multiple predictors and polymorphism-mutation genotype analyses (Pereira et al., 2014; Shiao & Yu, 2016). Through the process of triangulation, a source of heterogeneity could be explored and identified for divergent mutation rates of MTHFR polymorphisms and breast cancer risk. GIS maps were generated using JMP 12.1 software (SAS, 2015) to manage metadata specification of the geospatial data set. These maps helped associate regional patterns of polymorphism-mutations and breast cancer risk with the level of air pollution per country (Albrecht, 2007). In addition, a partition tree model was used to examine the associations between multiple predictors and outcome variables. Recursive partition analysis using JMP 12.1 software created a decision tree that classified groups of population (MTHFR polymorphism-mutation rates in cases and control groups and risks) by splitting data into subgroups based on levels of APD, their independent variable (Strobl, Malley, & Tutz, 2009). In each analysis, Akaike's Information Criterion (AIC) was used to select the optimal number of subgroups; the model that yields the smallest value of AIC is selected (Akaike, 1985). We conducted Tukey's test for pairwise comparisons to identify any difference between two means that exceeded the expected standard error (Abdi & Williams, 2010, p. 1565). We used heat maps (SAS JMP Program) as a graphical representation of data to visualize the matrix values represented on a color scale. The heat map cluster results revealed rows (levels of APD) and columns (MTHFR polymorphism-mutation genotype rates) of hierarchical cluster structure in a data matrix that supplemented detailed analysis of the underlying associations between variables. Back to Top | Article Outline RESULTS Pooled Analyses For pooled analysis of MTHFR genotypes, we included 82 studies in our MTHFR 677 group, with 36,683 breast cancer cases and 40,689 controls (Table 1). Using the control group as the reference for the general healthy population, the rank order of subgroups with the MTHFR 677 TT (homozygous) mutation was Middle East (13.57%) followed by U.S. mixed (12.63%), East Asian (12.22%), Caucasian (11.28%), Brazil mixed (10.69%), and South Asian (2.97%; for specific percent mutations per control and case groups, see Figure S1, Supplemental Digital Content 2, http://links.lww.com/NRES/A216, MTHFR 677). On the test of association, MTHFR 677 TT was a risk genotype for breast cancer in the total sample (RR = 1.13, 95% CI [1.06, 1.21], p = .0004) and for the East Asian subgroup (RR = 1.22, 95% CI [1.06, 1.40], p = .005). Mexico, Ecuador, and Morocco each had one study; these three also showed 677 TT as a risk genotype (Figure 3). MTHFR 677 CC (wild type) was a protective genotype for the total sample (RR = 0.97, 95% CI [0.95, 0.99], p = .007), as well as for the East Asian subgroup (RR = 0.95, 95% CI [0.90, 0.10], p = .04). With the combined model of MTHFR 677 TT and CT genotypes, both polymorphism-mutations were noted to be risk genotypes for breast cancer (RR = 1.03, 95% CI [1.01, 1.05], p = .003). TABLE 1 FIGURE 3 GIS maps enhanced the visualization of geographic regional patterns of MTHFR 677 polymorphisms-mutations and breast cancer risks in countries worldwide (see Figure S3, Supplemental Digital Content 4, http://links.lww.com/NRES/A218, Combined MTHFR 677 TT and CT Polymorphism-Mutation Genotypes). GIS maps identify populations geographically, whereas racial-ethnic data may be mixed because ethnic groups are scattered in various countries (see Figure S4, Supplemental Digital Content 5, http://links.lww.com/NRES/A219, for MTHFR 677 TT homozygous mutation genotype; see Figure S5, Supplemental Digital Content 6, http://links.lww.com/NRES/A220, for CT heterozygous mutation genotype). Further use of global visualization showed that the highest polymorphism-mutation rates on MTHFR 677 TT were found in the Middle East (Iran and Saudi Arabia), Europe (Cyprus, Spain, Germany, Slovenia, and United Kingdom), Asia (Japan and China), and North America (Canada and United States) for the control group (see Figure S4, Supplemental Digital Content 5, http://links.lww.com/NRES/A219). As noted in the map for risk of breast cancer from MTHFR 677 TT mutations (see Figure S4, Supplemental Digital Content 5, http://links.lww.com/NRES/A219, the third map), the darkest color (red) depicted the highest breast cancer risks in Australia, South Korea, China, Pakistan, Turkey, Syria, Italy, Cyprus, Greece, Croatia, Poland, Canada, Mexico, and Ecuador. To identify the sources of heterogeneity in racial-ethnic subgroups, studies per country were grouped together with TT as risk genotype (RR > 1) or protective genotype (RR < 1). This strategy clearly depicted groups of countries with the same trends (Figures 2 and 3) or those with heterogeneous variations within each country (see Figure S6, Supplemental Digital Content 7, http://links.lww.com/NRES/A221; RR = 1.35, 95% CI [1.22, 1.49], p ≤ .0001) and protective (RR = 0.90, 95% CI [0.82, 0.98], p = .02) genotypes (Table 1). Countries or regions with MTHFR 677 TT as risk genotype were Australia, Russia, South and East Europe (Sweden, Turkey, Cyprus, Greece, Croatia, and Italy), America (Canada, Mexico, Ecuador), East Asia (South Korea and China), Middle East (Pakistan, Syria, and Saudi Arabia), and Morocco (Figure 3). Conversely, countries or regions with MTHFR 677 TT as a protective genotype were North Europe (Finland, Slovenia, Germany, and United Kingdom), Brazil, Southeast Asia (Singapore and Thailand), and other parts of the Middle East (Kazakhstan, Iran, and Jordan; Figure 4). Comparative results of OR and RR were presented. As projected, RRs presented more conservative results than ORs (see Table S2a, Supplemental Digital Content 8, http://links.lww.com/NRES/A222). FIGURE 4 On the pooled analysis of MTHFR 1298 genotypes, 50 studies were included with a total of 23,252 cases and 27,094 controls (Table 2). Using the control group as a reference for the general healthy population, the rank order of MTHFR 1298 CC (homozygous) mutation was Caucasian (14.58%) followed by Middle East (10.59%), U.S. mixed (8.38%), East Asian (5.57%), South Asian (5.32%), and Brazil mixed (5.10%; for specific percent mutations per case and control groups, see Figure S2, Supplemental Digital Content 3, http://links.lww.com/NRES/A217, MTHFR 1298). For visual examination, GIS maps were also generated (see Figure S7, Supplemental Digital Content 9, http://links.lww.com/NRES/A223, Combined MTHFR 1298 CC and AC Polymorphism-Mutation Genotypes; see Figure S8, Supplemental Digital Content 10, http://links.lww.com/NRES/A224, MTHFR 1298 CC Homozygous Mutation Genotype; see Figure S9, Supplemental Digital Content 11, http://links.lww.com/NRES/A225, AC Heterozygous Mutation Genotype). For the control group, the highest mutation rates on MTHFR 1298 CC were located in Europe (Cyprus, United Kingdom, Finland, Germany, Poland, Greece, Sweden, and Russia) and the Middle East (Iran, Syria, and Jordan; see Figure S8, Supplemental Digital Content 10, http://links.lww.com/NRES/A224). On the maps for breast cancer risk from MTHFR 1298 CC mutations (see Figure S8, Supplemental Digital Content 10, http://links.lww.com/NRES/A224, third map), the darkest red depicted the highest breast cancer risks, in China, Thailand, Pakistan, Kazakhstan, Syria, Jordan, Slovenia, Italy, Spain, Brazil, and Ecuador. TABLE 2 Additional subgroup analyses based on risk groups were more revealing for MTHFR 1298 (see Figure S10, Supplemental Digital Content 12, http://links.lww.com/NRES/A226, Figure S11, Supplemental Digital Content 13, http://links.lww.com/NRES/A227, and Figure S12, Supplemental Digital Content 14, http://links.lww.com/NRES/A228, Forest Plots). Pooled analyses showed statistically significant results on opposing subgroups of MTHFR 1298 CC as risk (RR = 1.20, 95% CI [1.05, 1.37], p = .006) and protective (RR = 0.84, 95% CI [0.73, 0.97], p = .02) genotypes (Table 2). Countries or regions with MTHFR 1298 CC mutation as a risk genotype were North and South Europe (Sweden, Poland, Turkey, Cyprus, Greece, Slovenia, Italy, and Spain), Ecuador, Southeast Asia (Thailand and India), and the Middle East (Kazakhstan, Pakistan, Syria, and Jordan; see Figure S10, Supplemental Digital Content 12, http://links.lww.com/NRES/A226). Contrarily, countries or regions with MTHFR 1298 CC as a protective genotype were Australia, Russia, North Europe (Finland, Germany, and United Kingdom), Canada, Japan, Singapore, and Iran (see Figure S11, Supplemental Digital Content 13, http://links.lww.com/NRES/A227). Comparison of RRs and ORs for MTHFR 1298 also presented results similar to those for MTHFR 677, with RRs being more conservative than ORs (see Table S2b, Supplemental Digital Content 8, http://links.lww.com/NRES/A222). Back to Top | Article Outline Air Pollution, MTHFR Mutations, and Breast Cancer Risks On the metapredictive analysis, although all potential risk factors including quality score, source of controls, and types of breast cancer were explored, the level of APD was the only significant contributing factor for the polymorphism-mutations and breast cancer risks (e.g., see Figure S13, Supplemental Digital Content 15, http://links.lww.com/NRES/A229). To show metaprediction, we used partition trees (split groups) and the Tukey's test by levels of APD to predict MTHFR 677 genotype mutation rates and breast cancer risk (Table 3). The partition tree and Tukey's test results converged and showed significant differences between APD Levels 2 and 3 (p = .001) and between Levels 2 and 4 (p = .009) for MTHFR 677 TT rate by APD for control group. We noted the same trend of statistical significance by APD on the 677 TT in breast cancer cases and by APD on MTHFR 677 CT and CC genotype rates in both control and breast cancer cases. Furthermore, on the RR for MTHFR 677 CT, we identified significant differences between Levels 2 and 3 (p = .009) and Levels 2 and 4 (p = .02) APD, with the smallest AIC of 22.66 (smallest value is the best model). For MTHFR 1298, we conducted the same sequence of analyses. The partition tree and Tukey's test did not render any statistically significant differences among the tested associations (see Table S3, Supplemental Digital Content 16, http://links.lww.com/NRES/A230, 677 TT and CT M). TABLE 3 We further explored the nonlinear fit between our potential contributing factor—levels of APD—and percent MTHFR 677 TT homozygous mutation per control and breast cancer case groups (see Figure S14a, Supplemental Digital Content 17, http://links.lww.com/NRES/A231). As the level of APD increased from Level 2 to Level 3, TT genotype percent rate increased; however, we noted a slight decline on the mutation genotype rate when the level further increased to Level 4. We noted a similar trend in MTHFR 1298 CC (homozygous) mutation genotype rate although the curve was noticeably flatter (see Figure S14b, Supplemental Digital Content 17, http://links.lww.com/NRES/A231). Another illustration of associations between variables was presented through heat maps. On percent MTHFR 677 TT by levels of APD, data density with red blocks depicted higher concentration of 677 TT with air pollution Level 4 (see Figure S15, Supplemental Digital Content 18, http://links.lww.com/NRES/A232, MTHFR 677 TT Genotype). For percent MTHFR 1298 CC, red blocks with high data concentration dropped as air pollution progressed from Level 3 to Level 4 for both case and control groups (see Figure S15, Supplemental Digital Content 18, http://links.lww.com/NRES/A232, MTHFR 1298 CC Genotype). Back to Top | Article Outline DISCUSSION Compared to previous meta-analyses, this metaprediction study presents the most comprehensive report on MTHFR and breast cancer in that this study employed triangulation techniques beyond the conventional pooled and subgroup analyses. This study clearly addresses heterogeneity as a factor causing inconsistent, conflicting results in previous studies, and this study presents the potential source of that heterogeneity. Consistent with recent meta-analyses (Xie et al., 2015; Zhong et al., 2014), overall pooled analysis in this study showed that the MTHFR 677 TT was a risk genotype for breast cancer susceptibility (p = .0004) across all populations and specifically for East Asians (p = .005). However, there was heterogeneity with opposing findings for regions, findings that we summarized and integrated here across studies using different analytics. The countries and regions that presented opposing findings included Northern Europe, Southeast Asia, the Middle East, and Brazil. Global maps showed that the highest polymorphism-mutation rates on MTHFR 677 TT were found in the Middle East, Europe, Asia, and America for the control group. On MTHFR 1298, the highest mutation rates were located in Europe and the Middle East for the control group. The GIS maps further revealed higher risks of breast cancer for the countries or regions including Australia, East Asia, the Middle East, South Europe, Morocco, and the Americas based on MTHFR 677 TT mutations and Asia, Middle East, South Europe, and South America based on MTHFR 1298 CC mutations. Essentially, the GIS maps presented the potential source of heterogeneity in regional patterns across the world. The results from GIS maps and conventional pooled analysis to identify subgroups of risk regions converged with slight differences. In addition to results that were vividly presented in color, GIS maps pooled mutation rates and risks without weighting the sample sizes of each study. The conventional pooled analyses, however, weighted the sample sizes of each study when calculating the risks. To further understand the source of heterogeneity in pooled analyses, we added metapredictive analyses, and we included graphical data for visualization. We used recursive partition trees, nonlinear curve fit, and heat maps to examine complex associations in nonlinear exposure-response patterns. These techniques were most helpful not only to visually detect the regional geographical patterns of the increased mutation rates and risks but also to triangulate the findings with multiple prediction methods to validate the results across the methods. For associated environmental factors, this metapredictive analysis revealed that air pollution level was significantly associated with MTHFR 677 TT polymorphism-mutation and an increased trend toward breast cancer risk. Studies have shown that exposure to air pollution is associated with the development of breast cancer and increased mortality rates for breast cancer (Chen & Bina, 2012; Gorham, Garland, & Garland, 1989; Reding et al., 2015). Air pollution due to industrialization could be adding to the effect of global warming, which could further exacerbate the decreased enzymatic function of MTHFR 677 TT in warm environmental temperature, leading to increased breast cancer susceptibility. Thus, air pollution as an exogenous factor could not only detrimentally affect the MTHFR gene expression that results from genotoxicity (DeMarini, 2013), but air pollution could also be a factor in MTHFR gene mutations and associated risks for breast cancer. Therefore, the findings from this metaprediction support regulatory initiatives for clean air to attain global health. Other sources of heterogeneity for gene mutations have been identified and associated with human migration and gene–environment interactions (Chen & Bina, 2012; Gaudet et al., 2013; Xu et al., 2011). Findings from this analysis uncovered the potential source of that heterogeneity from geographical regions as it affects MTHFR polymorphism-mutations and breast cancer risk. This new scientific discovery accrued from our analysis via SAS JMP. To illustrate comprehensive standardized risk ratios, we presented a comparative analysis of RR and OR using the total counts of the three genotypes (homozygous mutation, heterozygous mutation, and wild type). The results from the tests of heterogeneity and associations were comparable, but RR presented more conservative results than OR in the pooled analyses. Back to Top | Article Outline CONCLUSION We have presented the most comprehensive meta-analyses of MTHFR 677 and 1298 genotype polymorphism-mutations and breast cancer risk by presenting the sources of potential heterogeneity using metapredictive techniques. In this study, air pollution was notably the most significant contributing factor associated with MTHFR polymorphism-mutations and potential breast cancer susceptibility. These findings provided new understanding that will guide future epigenetics research into the effects of air pollution on the development of breast cancer. Nurses in the community could play a significant role in primary prevention as they advocate for clean air and engagement of our profession in environmental regulations. We recommend future studies to examine the potential ways to detoxify and mitigate the systemic effects of pollution to improve health outcomes, thereby promoting health for the world's population.Back to Top | Article Outline REFERENCES Abdi H., & Williams L. J. (2010). Tukey's honesty significant difference (HSD) test. In Salkind N. (Ed.), Encyclopedia of research design (Vol. 3, pp. 1565–1570). Thousand Oaks, CA: Sage. Cited Here... Akaike H. (1985). Prediction and entropy. In Atkinson A. C., Fienberg S. E. (Eds.), A celebration of statistics (pp. 1–24). New York, NY: Springer. Cited Here... Albrecht J. (2007). Key concepts and techniques in GIS. Thousand Oaks, CA: Sage. Cited Here... American Cancer Society. (2016). Cancer facts & figures 2016. Atlanta, GA: Author. Retrieved from http://www.cancer.org/acs/groups/content/@research/documents/document/acspc-047079.pdf Cited Here... Chen F., & Bina W. F. (2012). Correlation of White female breast cancer incidence trends with nitrogen dioxide emission levels and motor vehicle density patterns. Breast Cancer Research and Treatment, 132, 327–333. doi:10.1007/s10549-011-1861-z Cited Here... Deeks J. J., Higgins J. P. T., & Altman G. (2011). Analysing data and undertaking meta-analyses. In Higgins J. T. P., Green S. (Eds.), Cochrane handbook for systematic reviews of interventions, Version 5.1.0 (Chapter 9.5.2). 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B., Ahumada V., Bustos V., Arraztoa J. A., … Illanes S. E. (2013). Levels of key enzymes of methionine-homocysteine metabolism in preeclampsia. Biomed Research International, 2013, 731962. doi:10.1155/2013/731962 Cited Here... Pooja S., Carlus J., Sekhar D., Francis A., Gupta N., Konwar R., … Rajender S. (2015). MTHFR 677C>T polymorphism and the risk of breast cancer: Evidence from an original study and pooled data for 28031 cases and 31880 controls. PLOS ONE, 10, e0120654. doi:10.1371/journal.pone.0120654 Cited Here... Reding K. W., Young M. T., Szpiro A. A., Han C. J., DeRoo L. A., Weinberg C., … Sandler D. P. (2015). Breast cancer risk in relation to ambient air pollution exposure at residences in the Sister Study cohort. Cancer Epidemiology Biomarkers & Prevention, 24, 1907–1909. doi:10.1158/1055-9965.EPI-15-0787 Cited Here... Shiao S. P., & Yu C. H. (2016). Metaprediction of MTHFR gene polymorphism-mutations and associated risk for colorectal cancer. 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Odds ratios and risk ratios: What's the difference and why does it matter? Southern Medical Journal, 101, 730–734. doi:10.1097/SMJ.0b013e31817a7ee4 Cited Here... Weisberg I., Tran P., Christensen B., Sibani S., & Rozen R. (1998). A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Molecular Genetics and Metabolism, 64, 169–172. doi:10.1006/mgme.1998.2714 Cited Here... World Health Organization. (2009). Deaths attributable to urban air pollution, 2004. From Global Health Risks, WHO 2009 [Global map illustration]. Retrieved from http://www.who.int/heli/risks/urban/en/uapmap.1.pdf?ua=1 Cited Here... World Health Organization. (2015). World Health Organization: 2014 air pollution ranking. Retrieved from http://aqicn.org/faq/2015-05-16/world-health-organization-2014-air-pollution-ranking/ Cited Here... Wu Y. -L., Ding X. -X., Sun Y. -H., Yang H. -Y., & Sun L. (2013). Methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and susceptibility to Parkinson's disease: A meta-analysis. Journal of the Neurological Sciences, 335, 14–21. doi:10.1016/j.jns.2013.09.006 Cited Here... Xie S. -Z., Liu Z. -Z., Yu J. -H., Liu L., Wang W., Xie D. -L., & Qin J. -B. (2015). Association between the MTHFR C677T polymorphism and risk of cancer: Evidence from 446 case–control studies. Tumor Biology, 36, 8953–8972. doi:10.1007/s13277-015-3648-z Cited Here... Xu X., Gammon M. D., Jefferson E., Zhang Y., Cho Y. H., Wetmur J. G., … Chen J. (2011). The influence of one-carbon metabolism on gene promoter methylation in a population-based breast cancer study. Epigenetics, 6, 1276–1283. doi:10.4161/epi.6.11.17744 Cited Here... Yadav S., Hasan N., Marjot T., Khan M. S., Prasad K., Bentley P., & Sharma P. (2013). Detailed analysis of gene polymorphisms associated with ischemic stroke in South Asians. PLOS ONE, 8, e57305. doi:10.1371/journal.pone.0057305 Cited Here... You W., Li Z., Jing C., Qian-Wei X., Yu-Ping Z., Weng-Guang L., & Hua-Lei L. (2013). MTHFR C677T and A1298C polymorphisms were associated with bladder cancer risk and disease progression: A meta-analysis. DNA and Cell Biology, 32, 260–267. doi:10.1089/dna.2012.1931 Cited Here... Zhang B., Beeghly-Fadiel A., Long J., & Zheng W. (2011). Genetic variants associated with breast-cancer risk: Comprehensive research synopsis, meta-analysis, and epidemiological evidence. Lancet Oncology, 12, 477–488. doi:10.1016/S1470-2045(11)70076-6 Cited Here... Zhong S., Chen Z., Yu X., Li W., Tang J., & Zhao J. (2014). A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in breast cancer. Molecular Biology Reports, 41, 5775–5785. doi:10.1007/s11033-014-3450-9 Cited Here... Zidan H. E., Rezk N. A., & Mohammed D. (2013). MTHFR C677T and A1298C gene polymorphisms and their relation to homocysteine level in Egyptian children with congenital heart diseases. Gene, 529, 119–124. doi:10.1016/j.gene.2013.07.053. PMID: 23933414 Cited Here... Ziegler A., Van Steen K., & Wellek S. (2011). Investigating Hardy-Weinberg equilibrium in case-control or cohort studies or meta-analysis. Breast Cancer Research and Treatment, 128, 197–201. doi:10.1007/s10549-010-1295-z Cited Here... Keywords:air pollution; breast cancer; geographic information systems; meta-analysis; MTHFR gene Supplemental Digital Content NRES_2016_11_30_SHIAO_16097_SDC1.docx; [Word] (93 KB) NRES_2016_11_30_SHIAO_16097_SDC2.docx; [Word] (2.43 MB) NRES_2016_11_30_SHIAO_16097_SDC3.docx; [Word] (2.42 MB) NRES_2016_11_30_SHIAO_16097_SDC4.docx; [Word] (164 KB) NRES_2016_11_30_SHIAO_16097_SDC5.docx; [Word] (170 KB) NRES_2016_11_30_SHIAO_16097_SDC6.docx; [Word] (170 KB) NRES_2016_11_30_SHIAO_16097_SDC7.docx; [Word] (29 KB) NRES_2016_11_30_SHIAO_16097_SDC8.docx; [Word] (30 KB) NRES_2016_11_30_SHIAO_16097_SDC9.docx; [Word] (171 KB) NRES_2016_11_30_SHIAO_16097_SDC10.docx; [Word] (168 KB) NRES_2016_11_30_SHIAO_16097_SDC11.docx; [Word] (166 KB) NRES_2016_11_30_SHIAO_16097_SDC12.docx; [Word] (24 KB) NRES_2016_11_30_SHIAO_16097_SDC13.docx; [Word] (20 KB) NRES_2016_11_30_SHIAO_16097_SDC14.docx; [Word] (25 KB) NRES_2016_11_30_SHIAO_16097_SDC15.docx; [Word] (26 KB) NRES_2016_11_30_SHIAO_16097_SDC16.docx; [Word] (33 KB) NRES_2016_11_30_SHIAO_16097_SDC17.docx; [Word] (38 KB) NRES_2016_11_30_SHIAO_16097_SDC18.docx; [Word] (36 KB) Back to Top | Article OutlineCopyright © 2017 Wolters Kluwer Health, Inc. All rights reserved Article Outline Abstract Significance and Objectives METHODS Design Included Studies Characteristics of Original Studies Data Synthesis and Analysis RESULTS Pooled Analyses Air Pollution, MTHFR Mutations, and Breast Cancer... DISCUSSION CONCLUSION REFERENCES Supplemental Digital Content Source MTHFR Gene Polymorphism-Mutations and Air Pollution as Risk Factors for Breast Cancer: A Metaprediction Study Nursing Research66(2):152-163, March/April 2017. Full-Size Email + Favorites Export View in Gallery Email to a Colleague Colleague's E-mail is Invalid Your Name: (optional) Your Email: Colleague's Email: Separate multiple e-mails with a (;). Message: Thought you might appreciate this item(s) I saw at Nursing Research. Send a copy to your email Your message has been successfully sent to your colleague. Some error has occurred while processing your request. Please try after some time. 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Little Matador's members have plenty of history in bands from Snow Patrol to Idlewild and beyond, come from Belfast, Dublin and Portland and collectively blow the shit out of rock music like seemingly only duo's have been doing lately. This little tour video is from their recent live shows with QOTSA, Jimmy Eat World and Nine Inch Nails and the track from the video, Boom Boom features in the Liar Liar EP below. Big, ballsy and creative rock music, this is pretty fantastic.
f Little Matador
Hot New Stuff // Little Matador, Liar Liar EP
Posted Thursday, December 19, 2013
Labels: Boom Boom, Hot New Stuff, Liar Liar EP, Little Matador


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By Patricia Boccadoro
MARTIGNY, SWITZERLAND, 11 November 2006— Fifty-one masterpieces of European art from the Metropolitan Museum of Art, New York are currently being presented at the Pierre Gianadda Foundation in Martigny, Switzerland. Dating from a 1590 Caravaggio to a delicate 1899 work by Klimt, they have been displayed according to their country of origin to show the evolution of the different styles and themes in Europe over the centuries. Starting with the Italian section, the oldest school of all, works representing the Flemish, Austrian, Spanish and English schools are all on display. Interestingly, thirty-four of these works have been donated or are on loan from private owners.
However, although the exhibition is obviously of
great historical interest, the overwhelming sensation upon entering the
Espace Gianadda in Martigny is the sheer mass of colour and beauty that
hits you in the spacious hall. This is no hallowed place where people peer
through filtered lighting and speak in hushed whispers. These sumptuous
paintings, each lit from above, have been most attractively hung around
the walls and are instantly visible, not half hidden in smaller rooms or
galleries. Whichever way one turns there is a Van Gogh, a Sisley, a Manet,
Renoir, El Greco or Stubbs. No need to be a connoisseur of art to enjoy an
exhibition here.
Poussin himself was inspired by the legend of king Midas who changed everything he touched into gold, and, unable to eat or drink, broke the spell by bathing in the river Pactole. Logically influenced by these two works, Courbet united religion and mythology in The Source , completed some 250 years later. Is the naked woman in his painting a goddess or a simple peasant girl?
In the seventeenth century, painting was dominated by the Flemish school, when artistic inspiration sprang from everyday life, and a series of works in this lively exhibition portray people at home going about their daily activities. Paintings began to be full of amusing small details. Jan Steen, for example, turned towards the theatre and popular literature of the time in The Lovesick Maiden , where a doctor is taking a young girl's pulse under the eyes of a servant. The painting is full of allusions to her lovesickness, culminating in the two copulating dogs in the forefront of the picture!
The exhibition also boasts many portraits, from the curious Portrait of a Woman in Grey by Degas, an artist more usually associated with dancers or "keyhole" paintings of washerwomen, to the romantic and surprising self portrait of Van Dyck at the age of twenty. Most powerful of all, perhaps, is Rembrandt's Le Porteur d'étendard . Rembrandt has depicted the man, Floris Scoop, a wealthy art collector, in his feathered hat, carrying sword and standard, his uniform of the Municipal Guard of Amsterdam.
Francisco de Goya's haunting José Costa y Bonells dit Pepito, completed in 1813, during the Napoleonic war, merits far more than a cursory glance. It is a painting which conveys both the humour and tenderness the artist felt towards this sad small boy decked out in his soldier's uniform, the toy drum, horse and gun behind him. Innocence associated to the horrors of war.
The Espace Pierre Gianada, too, has a special history. The land, in the foothills of the Swiss Alps was initially bought by Leonard Gianadda to build an apartment block, but when work began, the remains of a Celtic temple was discovered. This discovery coincided with the death of Gianadda's younger brother, Pierre, who lost his life while rescuing fellow survivors from a plane crash. Leonard decided to create a Foundation in his memory, and built this remarkable cultural centre, inaugurated on November 19, 1978, the day that would have been his brother's fortieth birthday. The main foyer housing the paintings was thus erected on the site of the temple, while gardens were created around the ruins of a sanctuary.
Since then, a succession of prestigious exhibitions of great and lesser known artists have been shown, and when I was there in October, a concert featuring the Lausanne Chamber Orchestra, with Canadian violinist, Corey Cerovsek was held in the main foyer. Surrounded by all the masterpieces, with Manet's Le Guitarist looking on and almost joining in a couple of metres away, although by looking at the way he is holding his instrument, it was just as well he wasn't.
Concerts up until May 2007 include a recital by Cecilia Bartoli, the Camerata of Lausanne with Pierre Amoyal and Brigitte Meyer, Joshua Bell and Jeremy Denk, Fazil Say, OSR conducted by Armin Jordan, and the Academy of St. Martin in the Fields (for further information, contact the Foundation Gianadda) while the next exhibition presents the paintings, drawings and engravings of Swiss artist, Edouard Vallet.
After Martigny, Masterworks of European Painting from The Metropolitan Museum of Art, New York: From El Greco to Cézanne will be on view at the Museu Nacional d'Art de Catalunya, Barcelona, Spain from 30 November 2006 to 4 March 2007.
The Metropolitan Museum of Art, New York:
Chefs-d'oeuvre de la peinture européenne
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The Leading 17 Best Style Bloggers In UK
Mercedes Benz Fashion Week is a semi-annual occasion held in significant cities all through the planet. Style Marmalade was swiftly recognized in the fashion world and was brief listed by Cosmopolitan as one particular of the best new style blogs and has been featured on , New York Instances, MTV, Elle, Vogue and Societe Perrier, Victoria now collaborates with many international brands, photographers, artists and designers and her site remains a single of the most exclusive style web sites online.
Around 80 designer shows occur over the course of eight days in the respective months and about one hundred,000 fashion sector insiders attend the occasion producing the fashion show a prime chance to exchange suggestions and compete for company. Children and the youth making choices across the planet that influence style for people everywhere Street style is far more than fashion. Without having these people who craft and generate their own fashion according to their personal sense of fashion style, we'd be lost.
She produced her blog after her YouTube fans requested additional expound upon her fashion and beauty interests. Even so, style had changed, there would no longer be a single prevailing fashion trend but a excellent plethora of influences creating endless possibilities. There is no fixed schedule for these shows in any of the major fashion capitals but they typically come about 3 months after the principal season shows.
Erica Davies, With over fifteen years expertise in the fashion market as a beauty and style editor on national newspapers and magazines like The sun, The Appear and Everyday Mirror magazine, she surely earned her style credentials. In her weblog, She Wears Fashion she expresses her interest towards the vintage fashions and thrifted finds. Julien Macdonald OBE: This Welsh fashion designer received his MA at the Royal College of Art London, following his productive RCA graduation show in 1996, the designer was selected by Karl Lagerfeld, as head designer of knitwear for Chanel and the Lagerfeld label from 1996 to 1998.
Nottingham Fashion Week is getting organised by the Nottingham Company Improvement District (BID) in partnership with the Inventive Quarter. Come November, the occasion will be the ultimate style expo that provides a golden chance for professional buyers and shoppers alike to supply for the very best Malaysian and ASEAN designs for their Spring/Summer time 2017 collection," added Yeoh. The Vodafone London Style Weekend takes location this month at Somerset Residence, an event not to be missed. WHAT: Launched in 2009, Vestiaire Collective is Europe's leading social shopping site for pre-loved luxury style.


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Content warning—description of animal death
For today's #InnerWork Wednesday, I wanted to share the ritual I enacted after witnessing a violent squirrel death. This is the second dead animal I've come across in the last month; I also found a robin outside of my door which had likely passed from West Nile virus. Just as I try to drastically reduce my consumption of animal products, my access to their suffering has increased.
Witnessing Wildness
As I walked with my dog, I hear a ruckus in a neighbor's tree. My pup and I stopped to see what was causing all the commotion. Unexpectedly, three squirrels came hurdling at least ten feet from a nest in the tree and plopped on the ground. One landed with a smacking sound. My brain tried to sanitize what I'd just seen by telling me it was like a mother bird pushing her offspring out of the nest, even as I stood there covering my mouth with my hand, eyes bugging out. A single squirrel that remained in the tree squawked in victory.
I kept walking, believing everything was alright. As I passed the house on my way back, two neighbors came out, staring at the tree. I went over and explained what I'd seen. One of the men remarked that a squirrel, the one that landed with a thud, seemed like it might be dead. Before I could react, the other man started kicking and stomping on it. He kicked it into the bush where I could now see it. Its body laid there, still and silent. I felt sickened to my core and helpless. I was confused by the ambiguity of his actions—unsure if he was trying to "put it out of its misery" or if it was merely stunned and could have recovered. I left the scene but what I'd observed bothered me the rest of the day.
Words of Mourning
I decided to hold a small ritual to mourn the squirrel. Its manner of death was so abrupt and violent that I intuited on a visceral level the fear people have of ghosts and spirits who linger, unable to move on to their next destination. I've always conceptualized funerals as events designed to help the living grieve, but now I'm not so certain that they are the only ones in attendance. I burned some palo santo, lit a candle, and recited the following chant:
May Earth cradle.
May Air free.
May Fire guide.
May Water heal.
May your essence, emanating from Source, spiral its home in the cosmic web.
I also lit a candle outdoors the next day to finalize my actions. It flickered on and off like a heartbeat. Each time I thought it had been blown out by the wind, its flame started anew.
When I walked by the place of passing, the squirrel was gone.That is, its body had been removed or resurrected; I didn't have a strong sense of its spirit either, but the tree, now empty, felt closed-in and shadowed to me.
We pass every day near places where violence has occurred, often on a much grander scale than what I saw. We can do all we are able to stop these types of events. When they do happen, how do we integrate them into our experience? How do we heal them and ourselves of our participation in them? How do we remember and honor those who have passed?


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Read by August Ross
Synopsis: It's been months since the ghost of Anna Korlov opened a door to Hell in her basement and disappeared into it, but ghost-hunter Cas Lowood can't move on.
His friends remind him that Anna sacrificed herself so that Cas could live—not walk around half dead. He knows they're right, but in Cas's eyes, no living girl he meets can compare to the dead girl he fell in love with.
Now he's seeing Anna everywhere: sometimes when he's asleep and sometimes in waking nightmares. But something is very wrong...these aren't just daydreams. Anna seems tortured, torn apart in new and ever more gruesome ways every time she appears.
Cas doesn't know what happened to Anna when she disappeared into Hell, but he knows she doesn't deserve whatever is happening to her now. Anna saved Cas more than once, and it's time for him to return the favor.
My Thoughts: I absolutely loved the audio production of Anna Dressed in Blood! I was completely captivated by it and was terrified a few times. Though the ending was not what I expected, I felt that the first book was a perfect stand-alone. So I was surprised to learn that there was a sequel. I could not wrap my mind around as to what direction Ms. Baker took Anna and Cas' story in this second book. I was intrigued, though, to find out; plus, the cover just kept calling out to me. I decided to try the audio again since it worked out very well the first time.
The story definitely took a different route than the first book. Anna was in hell, there was a cult, and Cas' life was at stake. All of this would have sounded great but it didn't work out very well for me. I loved the parts of Anna. They were creepy and reminded me why I loved the first book. Unfortunately, there weren't many of these scenes. In fact, there wasn't much of Anna. The story mostly concentrated on Cas' obsession in trying to free Anna and how the cult wanted to replace the wielder of the athame. I was weirded out by Cas' obsession; it was just not healthy. I wanted to slap him and tell him that he needed to let Anna go even if she were in hell. The cult parts were a bit interesting but at the same time they were too boring. I didn't really see their purpose in the story other than to give background information on the athame.
I don't think I would have finished this book if it weren't for August Ross, the narrator of the production. Just like in the first audio, he was able to capture Cas' character very well. He was able to entertain me by the way he told the story. He especially made the creepy scenes with Anna quite chilling. August Ross did a wonderful job.
Overall, I liked the production and I liked the scary bits. Girl of Nightmares was not as good as the first book, but I'm glad that it gave Anna's character a decent ending. I rate it:


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email@example.com | 1-888-208-2246
The MaxDiscovery™ Rat IL-1β ELISA Test Kit is designed for quantitative determination of the concentration of rat IL-1β in serum, plasma, and cell culture supernatant.
Rat Interleukin-1 beta (IL-1β) is a ~17 kDa protein composed of 153 amino acids. IL-1β along with IL-1α, is a member of the IL-1 superfamily. IL-1α and IL-β are pro-inflammatory cytokines involved in immune defense against infection. IL-1α and IL-1β, are the products of distinct genes, but recognize the same cell surface receptors. IL-1α and IL-1β are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both proteins are produced by a wide variety of cells in response to stimuli such as those produced by inflammatory agents, infections, or microbial endotoxins. When stimulated by other cytokine growth factors, mRNA of IL-1β is present within 15 minutes and accumulates for 4 hours followed by a rapid fall that results in part from the synthesis of a transcriptional repressor as well as a decrease in mRNA half-life. IL-1β plays a role in signal transduction through its receptor, IL-1R. IL-1β is a converting enzyme, which plays an important role in apoptosis through nitric oxide.
Format: 96-well strip plate
Assay range: 30-1920 pg/mL
Sensitivity: 30 pg/mL
Total Assay Incubation Time: 3 hours and 45 minutes
Sample Size: 100 µL/well
Sample types: Serum, Plasma and Cell Culture Supernatant
Wavelength for plate reading: 450 nm


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Carl Frampton and Julio Cesar Chavez Jr. Highlight Huge Boxing Weekend in El Paso This Saturday, El Paso, Texas' Don Haskins Center will have the national boxing spotlight as not one but two boxing cards hit the Sun City. On the afternoon bill, CBS will televise a Premiere Boxing Champions, PBC on CBS card which will feature the highly anticipated United States debut ...Read More »
Julio Cesar Chavez Jr.
Julio Cesar Chavez Jr. and Marcos Reyes to do Battle July 18 in El Paso
Showtime Championship Boxing hits El Paso July 18 when Chavez Jr. takes on Reyes Looking to get back on track after the first TKO loss of his career, Julio Cesar Chavez Jr. heads to El Paso Texas to face hard-hitting Marcos Reyes July 18 at the Don Haskins Center. The two men are expected to fight at the Super Middleweight ...Read More »
UFC Albuquerque Card is Stacked, Remember the Last Big Combat Sports Event at the Tingley Coliseum?
If the UFC's first event in Albuquerque outdoes the last major national combat sports event at Tingley Coliseum, we're in for one hell of a night On June 7th the UFC is scheduled to host its first event in the state of New Mexico when UFC Fight Night: Henderson vs. Khabilov takes places inside Albuquerque's historic Tingley Coliseum. The 11-bout ...Read More »


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Please contact me today to learn more about our complete coverage plans designed to protect you, your home, and your automobile.


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PVCC: Stacey Evans's "Tracking People" and the Annual Art Faculty Exhibit
Piedmont Virginia Community College features two exhibits: in the South Gallery, local fave Stacey Evans shows "Tracking People," an exhibition of work from her "Trainscapes" series; and in the North Gallery, the stellar PVCC Art faculty presents its annual show, featuring work by Rick Weaver, Jeremy Seth Taylor, Fenella Belle, Rebekah Wostrel, Clay Witt, and many more. V. Earl Dickinson Building. 961-5202.


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Say, you want to draw a tree in full Spring, a very green one. Not just an outline you want details too so that you actually see the leafs. Unless you have a ton of time on your hands or you're paid by the hour, it would be a hell of a job to draw each leaf one by one. This would be one of the many situations where the Symbol Spaying Tool can be of assistance.
Step 1 - Create a few symbols to spray with
First of all you need to create a few symbols to have a bit of variation to work with. Instead of creating a symbol of only one leaf, I suggest to draw groups of leaves and make them separate symbols. To do this, just select the group of leaves and drag & drop them in the Symbols palette. I've used different shades of green for my leafs.
Step 2 - Set the Symbol Sprayer Tool
The second step is to double click the Symbol Sprayer Tool in the Toolbox and adjust the settings to your wishes. This can be a bit tricky and you might need to experiment a bit to find the setting that fits your purpose. I've used an intensity of 7 and a Symbol Set Density of 5. Furthermore I've changed all dropdown menus to "User Defined".
Step 3 - Let the fun begin and spray like you've never sprayed before
Once you've discovered the desired setting you can start spraying around. Oh and you don't have to worry about damaging the ozone layer here, you can spray like a madman :) Just click and drag, release the mouse when you think that there are enough leaves. I usually deselect each time I've released the mouse. This way you have all separate sprayings, so you can move them around and rearrange them a bit if needed.
Don't stop experimenting
If you're still not satisfied with the result, you can also tweak a bit by using the Symbol Shifter, Cruncher, Sizer, Spinner, Stainer, Screener or Styler Tool. These tools are hidden under the Symbol Sprayer Tool when you select and hold down the mouse. Think about the possibilities here in this tool and the amount of time you can save: a field full of flowers, a sky full of birds,... Ah Spring, can't wait till it's here. The weather forecast isn't looking that bad for this week.
Hope you enjoyed this tutorial.


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Blue Rodeo was in CBC Music's Studio 211 for a First Play Live of the band's latest album, 1000 Arms. We took a quick minute with guitarist Colin Cripps and asked him to show us his pick.
He tells us that "these are rare little picks to get. They're made in West Germany and they're made by a company called Herdim. These little beauties cost me about a buck a piece. Normally picks cost you 10 cents." He goes on to explain why he's willing to pay 10 times more than most guitarists for this prized pick, and how he uses it to make the strings sound brighter. Check it all out in the video below.
And if you liked the video above, watch more from the "Show Me Your Pick" series starting with Metallica's Kirk Hammet in the video below.


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I imagine the Asylum has wanted to mockbuster "The Expendables" since the first movie came out, but they ran into a problem – Stallone had already hired every washed up former action star, rendering their traditional casting methods moot. So, it remained un-Asylumed until someone had the great idea of making the cast women! And here we are with "Mercenaries".
After a joke which I presume is at the expense of the "Expendables 3" (about watches with GPS trackers in them) the cast greeting comes thick and fast. Brigitte Nielsen is the baddie Ulrika, trying to take over an unnamed former Soviet satellite state by kidnapping the US President's daughter; and hired to take her on are four women who you'll either sort of recognise or cheer in delight for, depending on how wasted your youth was.
Cynthia Rothrock, star of many many terrible martial arts movies, doesn't even fight in this one, being the boss of the team, and the person who offers 4 inmates presidential pardons if they'll help out Uncle Sam. Vivica A Fox is probably the best known of them, and Zoe Bell was hired more to do with her being one of the best stuntwomen of all time than being great at acting. Nicole Bilderback and Kristianna Loken, on the other hand, are both still in their prime and can act, so perhaps they were taking a punt on this becoming a surprise hit.
The thing is, this film is sort of good fun. Yes, it's cheap as hell, and they couldn't afford many big fight scenes, but it makes sense and gets from A to B reasonably and fairly quickly – sad as it is that a film that achieves basic competence needs to be singled out for praise. Our four heroes infiltrate Ulrika's compound, discover a bit of sex trafficking, try and rescue the President's daughter and prevent the bad guys from making off with a couple of ICBMs. No muss, no fuss.
The problem is everything else. I don't think all female-dominated films need to be written and directed by women, but with seemingly no female involvement in anything non-acting, there can be a tendency for it to not really sound "real". Weirdly, we've covered the entirety of the writing career of Edward DeRuiter ("3 Musketeers" and "Two-Headed Shark Attack"), and a lot of the directing career of Christopher Olen Ray (ensuring a second generation of poor quality filmmaking, after dad Fred) and while I've never noticed it before, the two of them seem entirely cloth-eared when it comes to women.
An example, I hear you ask? Bilderback – who despite being by a distance the best actor involved in this movie, so good that it's a shame she's doing this, but gets saddled with all the worst dialogue – says at one point "Let's go PMS from hell on this place". My wife, relatively quiet to this point, turned to me and said "women don't talk like that!" Vivica also expresses the desire, late on in the film, to "fuck George Clooney…with a strap-on". The banter is even worse than in the Expendables movies, a phrase I never thought I'd have to write.
That's not all of it, though – see what happens to the sex-traffic women; and the weird equation of strong women always being lesbians (although this film is a long way from being the only offender at that). It doesn't take a feminist to figure out that the men in charge of making this film might reasonably be said to have a few issues with women. What makes it even weirder is the women are pretty good at their jobs – apart from being rotten shots, a trait they share with everyone in this movie – and their gender isn't really an issue when it comes to fighting. For a cleverer skewering of this than I could manage, "From The Women's Desk" give it a great review.
So, apart from the banter being terrible and it being a fairly poor portrayal of women and it being cheap and how not much stuff really happens and how the weakest actor of the main four has to do most of the acting, it's a pretty fun movie. It seems from IMDB that a sequel is in post-production already, with the same writer, director and everyone who survived this one returning.
Rating: thumbs in the middle
GERALD WEBB ASYLUM WATCH: Yes. Rothrock's assistant. Good to see you Gerald!


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Scott Galloway, professor of marketing at the NYU Stern School of Business and the author of "The Four: The Hidden DNA of Amazon, Apple, Facebook, and Google," shows how some of the biggest successes in tech have also had major public failures. He explains why failure is an important aspect of success. Following is a transcript of the video.
Scott Galloway: So there's a famous chart that shows — it says, what people think success is and it has a straight upward line and then what success really is, and it's a jagged, multi-art adventure. And that is accurate.
Scott Galloway, professor of marketing NYU Stern and the author of "The Four: The Hidden DNA of Amazon, Apple, Facebook, and Google."
If you are not in your own professional life and your professional career kind of wiping out and getting beaned in the face every once in a while, you aren't trying hard enough. And these companies are great at failure.
They're fantastic at taking big risk. Putting metrics on them and just as importantly pulling the plug and performing infanticide on projects that aren't working and then moving on to the next thing. Whether it was auctions or the phone with Amazon or Facebook and some of their targeting, all of these companies have had huge missteps, but it just doesn't matter because they on average win.
They have a great batting average. And as Jeff Bezos said, they'll take a risk, a one-in-10 risk if they think it can pay off 100 times.
That isn't the way traditional companies think. Old-economy companies typically won't green-light anything unless it has more than a 50% chance of winning, and then even worse than that, after it's launched, and it's become the pet project of people at the top, everyone else enters into consensual hallucination with the CEO that this thing is working and sometimes let this kind of gross, ugly child live longer than it should.
So, one, these companies are more disciplined about taking more risk, but they're also more disciplined about pulling the plug on these things. This video was originally published on October 16, 2017.
Get the latest Google stock price here.


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|The Jargon Dictionary wrote:
social engineering n.
Term used among crackers and samurai for cracking techniques that rely on weaknesses in wetware rather than software; the aim is to trick people into revealing passwords or other information that compromises a target system's security. Classic scams include phoning up a mark who has the required information and posing as a field service tech or a fellow employee with an urgent access problem. See also the tiger team story in the patch entry.
|ShaolinTiger wrote:
|Social Engineering is 80% of hacking the majority of situations.
|Chozen1 wrote:
|I had a m8 do some Social Engineering.
He walked into an office in York, used an internal phone and rang one of the managers, told them he was security, they had a hacker in the system and he needed his usernames and passwords. Then walked out!
Cool EH!
|liquidz wrote:
|I think Kevin Mitnick said it, but humans are the weakest link in the security chain.
|WeeBit wrote:
|To me using Social Engineering to gather sensitive information from a business or even a home user is nothing more than a "con artist" at work hurting businesses or home users. I don't understand why when you discuss Social Engineering why you don't call it a con artist at work to do harm?
|A significant also part is the body languange , although it will take me a whole page to analyse it here...
output generated using printer-friendly topic mod, All times are GMT + 2 Hours


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AHÍ VA EL GOLPE, NO. 16: LA ULTIMA CENA. "AHÍ VA EL GOLPE" Y VA QUE RUGE A PEGARLE DE VERDAD, AL CACIQUISMO ASQUEROSO QUE SUFRE LA SOCIEDAD. Publicación quincenal
Beltrán, Alberto (Dir)
Price: $100.00
click image to zoom
Place Published: México, D.F
Publisher: (Ahi va El Golpe)
Date Published: 1o. de Febrero de 1956
Condition: (Marginaly worn on edges, some chipped; some foxing; o/w good copy)
Size: 28 cm
Pages: 4 pages
Book Id: 102395
b/w plates, draws., wrps., unbound
Very scarce periodical with the participation of TGP members. Liberal and critically humorous biweekly publication founded in 1955 and directed and illustrated by Alberto Beltrán (b. Mexico 1932-2002) with some illustrations by Leopoldo Méndez. Only one holding at University of New Mexico
- More: Book Arts
- More: MEXICO
- More: MENDEZ, LEOPOLDO
- More: CARICATURES
- More: ILLUSTRATION
- More: ART
- More: HUMOR
- More: CARTOONS
- By This Author: Beltrán, Alberto (Dir)
- By This Publisher: (Ahi va El Golpe)


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Ballinkillen 0-22 Arklow Rocks 0-07
Ballinkillen Senior Hurlers had another successful outing in the Leinster League this Saturday evening played in Ballinkillen in perfect conditions. With this performance the team are one result away from a play-off place on the next round. The team started with much the same personnel as the outfit which was successful in the previous round against Dunboyne.
Ballinkillen were on the attack from the throw in which resulted in a wide from Darren Dalton. It did not take long for another attack to produce the first score from play by Andrew Gaul "The Duke" in the second Minute. Arklow had two attacks before Peter Minchin playing at wing forward scoring from play on the 5th with David English slotting over a free on the 6th as a result of the Rocks centre back over carrying the ball from great pressure by the Darren Dalton and Derek Murphy refusing to let him clear his lines. Arklow started their account on the 9th from a free by their corner forward after David English was considered to have committed a third man tackle. Ballinkillen won a free from the puck out which resulted in their second wide by David English from 60 mts out. Arklow attacked from this puck out getting their second wide of the game. On the puck out Martin Minchin picked out Craig Wall on the wing and Craig skinned his opponent carried the ball to the 45 and opened his account for the day.
Arklow responded with two points from their full forward and right corner forward both resulted from mistakes by the back line that in fairness did not make the same errors for the rest of the game.
At this point Ballinkillen had the measure of their opponents and started throwing some good passages of play together, Marty Dalton scoring from the wing, then Duke punished a poor clearance, Sean Murphy stepped up next to win a ball on his 65 power forward and slot the ball over the bar, Darren Dalton stepped in next to convert a perfect pass from Duke on the 20th minute to leave the score 08points to 3 points in favour of Ballinkillen. The good hurling did not stop as the Ballinkillen Half back line were dominant and refused to let much ball through, Derek Murphy got his second point of the afternoon from a pinpoint pass from David English, Arklow at this point changed around their forwards to try and get some momentum but this mobile Ballinkillen team refused to stop hurling with Craig Wall scoring from the wing on the bank side. The score of the first half came in the 25th minute with David English winning a hard ball making ground and delivering it long to the 21 for Tommy Cummins who came out went to the rafters plucked it out of the air turned under pressure and slotted it over the bar. Ballinkillen got their last score of the first half with a point from David English on the 27th minute from play. Arklow scored the last two points of the half from 65 which resulted in a great block by Lauren Kinsells at corner back and the free for a pick up by the Ballinkillen Defender. At half time the score was Ballinkillen 0-12 Arklow 0-5 with ballinkillen having 8 wides in the process.
The second half started with Duke making way for James Kinsella going in at Centre Back, English going to midfield. Peter Minchin started the second half as he did the first except this time he scored the next 3 points in the 2nd 3rdand 5th minutes from hard work by the defence and good passes from Marty, Michael Murphy and English. Murphy who replaced Tommy Cummins (inj) on the 35th minute. Arklow were working hard but could not come to terms with the work rate and vision of the Ballinkillen players in the middle third of the field. Craig Wall scored on the 7th from a pass by English who was playing well at centre field. James Kinsella holding Centre back well his first game back looked fit and comfortable gave a great pass to Minchin to score again. Dion Wall at this point made his Senior Debut by going in right half-back for john Hughes. In doing so Dion was in no manner out of his depth and showed there is a bright future ahead of him with his work rate and tenacity on a number of occasions. David English provided the passes for Craig Wall to score the next two scores before Arklow got their first score of the second half in the 18th minute.
If Tommy Cummins got the score of the first half the score of the scone half came when a long ball was allowed through by Peter Minchin for Darren Dalton to pick up and slot over the bar, this showed the vision and understanding that the team is capable of when tuned in. Darren Scored the next when peter Minchin played and ball back from the corner to the 45m line for Darren to slot over.
Peter Minchin had the final say with his best performance in scoring his 5th in the half and 6th for game from free by English. This performance was a good workman like effort and shows what the team can achieve if they keep doing the hard work asked.
Next Match in next Saturday in Mulinavat with St, Bridgids of Westmeath on Monday a win here gets a playoff place.
Team: Martin Minchin, John Hughes, Sean Minchin, Lauren Kinsella, Keith Lennon, David English 0-2, Sean Murphy 0-1, Andrew Gaul 0-2, Craig Wall 0-5, Peter Minchin 0-6, Darren Dalton 0-3, Derek Murphy 0-1, Marty Dalton 0-1, Vincent Meaney, Tommy Cummins 0-1. Subs: James Kinsella for A. Gaul, Michael Murphy for Tommy Cummins, Dion Wall for John Hughes, Frankie Dowling and Val Brooks
Match Reports >


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This week's VBS Geek of the Week is Charles Williams from Wilkies Grove Baptist Church in Hickory, NC.
1. What has been your "geekiest" VBS moment?
Well, our church secretary cringes when my "VBS ordering" begins (which is usually the day after the current VBS ends). She never knows how many packages will be delivered or what might be in those packages. When the 2012 theme was announced, she wanted to know if I was going to purchase an airplane and have it delivered. Hmmm…. I thought! So, I created a pretty good replica of an airplane invoice with matching envelope and mailed it to the church for "payment". As chair of Budget and Finance, I had to sign it of course and "authorized" the purchase. She got a kick out it…..she passed it on to our Deacon Chair….he wasn't as calm until she had to explain!
2. What is your favorite VBS theme to date?
Actually, our church is new to LIFEWAY. We were with another company, but after seeing my own children visit churches that used Lifeway VBS, I was hooked! They fell in love with the excitement in the music, the lessons, and themes. I knew we had to make a change, so last year was our first year with LIFEWAY… so, I have to say that NYC was pretty great!! My kids Lillie and Harrison would probably vote for Saddle Ridge Ranch!
3. What makes you continue to do VBS year after year?
I truly love VBS and the excitement of the week! Our former pastor always said that VBS was the most important week on our church calendar. What other time do you get so many folks entering and exiting through your church doors hearing the gospel presented in a way that draws them in? How else does a church gather children together to worship….to watch kids so excited about the doors opening to "see and hear" what will be presented that night. They come to hear the good news of Jesus Christ! I always say that no matter how large our budget and no matter how many months of planning it takes…if one accepts Jesus Christ—it was all worth it!
4. How would you complete this sentence?
You might be a VBS geek if . . . your church (and your wife) lovingly refers to you as "THE VBS NERD!"
5. Will we see you at one of the VBS Previews?
ABSOLUTELY!! VIP seating! HA! Ridgecrest 2012…WILKIES GROVE WILL BE THERE!


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The New Orleans Super Bowl Host Committee will welcome the San Francisco 49ers and the Baltimore Ravens back to New Orleans for Super Bowl XLVII on Feb. 3, 2013.
Super Bowl XLVII will feature brothers John and Jim Harbaugh, head coaches for the Ravens and 49ers. This will mark the first time in NFL history that two brothers, will go head to head in a Super Bowl.
In Sunday's NFC Championship game, the 49ers overcame a 17-point deficit and beat the Atlanta Falcons 28-24 in Atlanta, making them the NFC Champions for the first time since the 1994-1995 season. The 49ers are no stranger to New Orleans, in 1990 they defeated the Denver Broncos 55-10 in the Superdome during Super Bowl XXIV. The 49ers, who finished the season 11-4-1, will attempt to join the Pittsburgh Steelers as the only franchises with six Super Bowl titles.
The Ravens (10-6) found themselves at the AFC Championship in Foxborough for the second straight year, only this time they defeated the New England Patriots 28-13 to secure their spot in Super Bowl XLVII. The Ravens have not made a Super Bowl appearance since 2001 when they defeated the New York Giants 33-7 at Super Bowl XXXV in Tampa – the first Super Bowl victory since the Ravens were established as a franchise in 1996.
"We are excited to welcome the players, coaches and fans of both of these great teams back to New Orleans for Super Bowl XLVII" said Host Committee Co-Chairs Mary Matalin and James Carville. " Our great city is back and better than ever, and the world is about to be reminded why New Orleans is a favorite destination for the Super Bowl. No city does it better than we do. Period."
The New Orleans Super Bowl Host Committee, led by the Greater New Orleans Sports Foundation, will host New Orleans' first Super Bowl since 2002. This is the 10th Super Bowl for New Orleans, tying South Florida for the most Super Bowl's hosted by a single city.
Super Bowl XLVII will be held on February 3, 2013 at the Mercedes-Benz Superdome. Kickoff is set for 5:30pm CST.


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note that with the exception of Dr. Pepper and Providence, these
stallions do not belong to us, they are stallions we have bred our
mares to. Some of these stallions belong to the Hanoverian State
Stud and are available through the German Verband. Follow the link
on our home page.
Escudo I is a well-muscled, expressive stallion of ideal
type. He was Champion of the 1994 Stallion Performance Test with
excellent scores in all categories. He won the jumping section,
and went on to become Hanoverian Showjumping Champion 5 year old
in 1996, and German National Reserve Champion 5 year old Jumper.
Escudo has already produced over 20 licensed sons.
Performance Test Overview 20.10.1994 Adelheidsdorf
Performance test: 300 days
Overall Score 134,38
Dressage. 115,73 8
Jumping. 144,9 1
Placement 1st out of 37 Stallions


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Ever since he was six weeks old, baby Kaiba often stopped breathing. The part of his windpipe that carries air to his left lung would suddenly collapse, leaving him unable to breathe and requiring emergency assistance every time.
Kaiba had a condition called tracheobronchomalacia. It's a rare condition – about 1 in 2,200 babies are born with tracheomalacia and most children grow out of it by age 2 or 3, although it is often misdiagnosed as asthma that doesn't respond to treatment.
Severe cases, like Kaiba's, are even more rare, and they are very frightening.
It's a condition that has bothered me for years. Children die from tracheobronchomalacia, but I hoped that help could be found for these children.
Kaiba's parents, April and Bryan, were left watching helplessly each time he stopped breathing, praying that something would change and doctor's predictions that he would never leave the hospital again weren't true.
They lived in Ohio but they were willing to go anywhere if it meant they could get help for Kaiba. Fortunately, they didn't have to go far.