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Welcome › Forums › General PowerShell Q&A › Module to Connect to Remote PS Enviroments
This topic contains 9 replies, has 4 voices, and was last updated by
June 21, 2016 at 12:54 pm #44118
So I created a Module to connect to my Office 365 Remote PS, and two on-perm PS environments.
I have loaded the Module and ran the three cmdlets that I use to run out of my powershell profile. However now cmdlets like Get-Mailbox are showing up after I connect to the remote PS Environment.
Here is part of the module.
Function Connect-Office365 { [CmdletBinding()] param ( [Parameter(Mandatory = $False)] [System.Management.Automation.PsCredential]$Credential = $Host.UI.PromptForCredential("Enter MSOL Admin Credential", "Enter the username and password of an MSOnline Administrator account.","","userCreds"), [Parameter(Mandatory = $False)] [System.Uri]$Uri = "https://ps.outlook.com/PowerShell-LiveID?PSVersion=5.0.10514.6" ) connect-msolservice -credential $credential $session = New-PSSession -ConfigurationName Microsoft.Exchange -ConnectionUri $Uri -Credential $Credential -Authentication "Basic" -AllowRedirection Import-PSSession $session -prefix EXO -AllowClobber Return $session }
June 21, 2016 at 1:29 pm #44126
I'm confused – you don't want Get-Mailbox to show up?
June 21, 2016 at 1:35 pm #44132
No they are not showing up. Whenever I try to run something that I normally would have ran before when I just had this as a profile script I get an error telling me it's not recognized.
get-mailbox : The term 'get-mailbox' is not recognized as the name of a cmdlet, function, script file, or operable program. Check the spelling of the name, or if a path was included,
verify that the path is correct and try again.
June 21, 2016 at 1:40 pm #44138
You applied a prefix to the imported commands. It'd be Get-ExoMailbox.
June 21, 2016 at 1:45 pm #44142
I still get the error when I try it with the prefix. The Moduletype is a Script. I'm not sure if this would matter?
June 21, 2016 at 1:56 pm #44146
No. Imported modules are always scripts – it's just a set of proxy functions, not the "real" functions.
So here's the thing I think you're running into: scope. Because you're creating the PSSession within a function, isn't it likely that the PSSession ceases to exist after the function runs? You can test that by running the function and then running Get-PSSession to see what sessions are available and what their status is. if the session isn't opened and available, then the proxy module can't do its job.
June 21, 2016 at 2:03 pm #44148
I was wondering about that myself but I do see the PSconnection.
PS H:\IT-Share> Get-PSSession | fl ComputerName : ps.outlook.com ConfigurationName : Microsoft.Exchange InstanceId : daf95a44-9417-46e7-8b37-b76363d8fe57 Id : 3 Name : Session3 Availability : Available ApplicationPrivateData : {SupportedVersions, ImplicitRemoting, PSVersionTable} Runspace : System.Management.Automation.RemoteRunspace State : Opened IdleTimeout : 900000 OutputBufferingMode : None DisconnectedOn : ExpiresOn :
June 21, 2016 at 2:21 pm #44150
Then... not sure. I'd probably try to manually load the proxy module, and look inside it (in the ISE) to make sure it contained the commands I thought it did.
September 7, 2016 at 2:08 pm #53742ParticipantTopics: 0Replies: 1Points: 0Rank: Member
I also use this script for using Exchange on-premises and Exchange Online command in 1 powershell. This script is also found here
What i would like to add to this script is automatic logging in to the Exchange Online envrionment.
As my powershell scripting knowledge is not very good i am not sure how to add this.
If i where to add to variable as such:
$password=(ConvertTo-SecureString -String "Password" -AsPlainText -Force)
What has to be adjusted to this command to get it to automatically log in:
[System.Management.Automation.PsCredential]$Credential = $Host.UI.PromptForCredential("Enter MSOL Admin Credential",
"Enter the username and password of an MSOnline Administrator account.","","userCreds"),
September 7, 2016 at 2:22 pm #53747ParticipantTopics: 17Replies: 573Points: 21Rank: Member
get-credential | export-clixml ohthreesixtyfive.xml
$creds = import-clixml ohthreesixtyfive.xml
Connect-MsolService -Credential $creds
The topic 'Module to Connect to Remote PS Enviroments' is closed to new replies.


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subset: commoncrawl


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This little cutie is Westie Walkies available HERE
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Items used:
Di's Digi Stamps: Westie Walkies
Pink Petticoat Papers
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Button & Hemp cord from stash
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text: Despite having a BA in English, I am more of a Science Fiction and Mystery reader. The Pulitzer Prize winners are a nice counterpoint to my usual reading. I am just starting out on this journey. Here is what I have read so far. My reactions are on my blog.


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Jeanette has been very active and president of several clubs and organizations since moving to Lafourche Parish. Her background in Interior Design is an added asset in servicing her clients.
Please check out our progress under Recent Developments and view new pictures taken on 2/16/09.
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In the fall of 2006, the first phase of Acadia Plantation TND is completed and approved by the City of Thibodaux.
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You've always been able to enter forecasts/targets for your Metrics. But entering historical data was most politely described as 'a bit fiddly'.
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Go to the Metric section and click the "Edit Metric Data" button at the top-right of the page.
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Any targets you've previously entered will be shown here. The actual values you've provided for your previous reports will also be shown.
This was developed based on feedback from others that use the system – so if you have any of your own suggestions on how we can improve the software for you then do get in touch.


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- Research
- Open Access
Mycobacterium avium subspecies paratuberculosis is not associated with Type-2 Diabetes Mellitus
© Rosu et al; licensee BioMed Central Ltd. 2008
- Received: 12 February 2008
- Accepted: 22 April 2008
- Published: 22 April 2008
The role of pathogenic mycobacteria in diabetes has been a focus of speculation since a decade without any meaningful insights into the mechanism of diabetes causation vis a vis mycobacterial factors. Two of our studies based on PCR identification of mycobacterial DNA and detection of antibodies specific to the recombinant antigens and whole cell lysates of the Mycobacterium avium subsp. paratuberculosis (MAP) shown a clear association of MAP with the presence of type 1 diabetes mellitus (T1DM).
In this study, we sought to investigate if or not type 2 diabetes (T2DM) patients harbour humoral responses to MAP. Using three different MAP antigen preparations, humoral antibody profiles were estimated for 57 T2DM patients and 57 healthy controls. Statistical analysis was performed with the Chi-square test with Yates' corrections.
We observed insignificant levels of humoral antibodies against recombinant heparin binding haemagglutinin (HbHA), glycosyl transferase (Gsd) and MAP whole cell lysate in the blood of subjects with T2DM as compared to healthy controls.
We found no obvious association of MAP with the incidence of T2DM in Sardinian patients.
- Mycobacterium Avium Subspecies Paratuberculosis
- Mycobacterium Avium Subsp
- Mycobacterium Avium Subspecies Paratuberculosis Infection
- Infectious Trigger
- Mycobacterium Avium Subspecies Paratuberculosis Bacterium
Mycobacterium avium subspecies paratuberculosis (MAP) is an important pathogen whose role in autoimmune diseases such as Crohn's disease and diabetes has been debated [1–4].
Type 2 diabetes mellitus (T2DM) has become an epidemic, and virtually no physician is without patients who have the disease [5, 6]. Adult-onset diabetes mellitus or type 2 diabetes haunts more than 10% of the population in western countries in the age of 30 years old or more [7] and about 20% of people above 75 years of age [8, 9]. Moreover, over the last decade, it has become apparent that type 2 diabetes is extending not only to the young adult population but also found in adolescents and even, occasionally, in children [5]. The incidence is on the rise due to increased longevity and life expectancy and change in lifestyles including dietary habits, diminishing physical activity and rampancy of obesity, an increasing trend in many countries [5, 6].
Type 1 diabetes mellitus (T1DM) on the other hand is an insulin deficiency syndrome wherein the role of an infectious trigger such as MAP is becoming increasingly evident [10, 11]. In our recent studies based on MAP specific DNA and antibody detection [10, 11], we observed MAP to be an important link in T1DM in Sardinian diabetic patients who were free of tuberculosis and Crohn's disease.
Previous work [12] demonstrated low levels of antibodies against the 65 kDa heat shock protein (Hsp65) in established T1DM and T2DM cases. Heat shock proteins play an important role in auto-immune diseases and infection [1, 8, 9, 12]. Human glutamic acid decarboxylase (Gad) the prime antigen in Type 1 diabetes has similar amino epitopes as that of Hsp65. Moreover, it is accepted that low levels of Hsp65 antibodies in patients with established diabetes is probably a manifestation of impaired immunity induced by the diabetic state.
In the present study, we show that T2DM patients from Sardinia, in contrast to those with T1DM, do not harbour significant levels of anti Map antibodies in their blood. This finding negates involvement of MAP in T2DM and thereby reaffirms our hypothesis that T1DM (as against T2DM) possibly results from MAP acting as an infectious trigger.
A total of 114 participants comprising of 57 patients with T2DM and 57 healthy controls were tested for the presence of MAP specific antibodies. Sera samples were obtained from these subjects after confirming that they were definitely negative for the presence of tuberculosis (negative to PPD and not BCG vaccinated) and autoimmune and genetic diseases other than diabetes. Clinical diagnosis for T2DM was confirmed in the Diabetology Service of the Sassari University Clinics prior to the enrolment of the test subjects. Blood samples were obtained after written informed consents and after approval of the ethics committee of the University of Sassari. Sera samples were made into aliquots and stored at -20°C for short term storage (<6 months) and -80°C for long term storage (>6 months).
Target diagnostic antigens such as recombinant HbHA. Gsd and the whole cell lysates of the MAP bacteria were available from our previous studies [11, 13].
Enzyme linked immunosorbent assay (ELISA) was performed to detect humoral response [in test subjects (T2DM) and controls] against the recombinant MAP antigens and the whole cell lysates. Briefly, 5 μg/ml of crude MAP lysate, HbHA and Gsd antigens in carbonate-bicarbonate buffer (14.2 mM Na2CO3, 34.9 mM NaHCO3, 3.1 mM NaN3, pH 9.5) were used individually to coat the wells of flat-bottom 96-well immunoplates (Maxisorp; Nunc, Roskilde, Denmark), overnight at 4°C. Next day, plates were blocked for 1 h with 200 μl of 5% non-fat dried milk (SIGMA) and following two washing steps with phosphate buffered saline (PBS) containing 0.05% Tween 20 (PBS-T), serum samples was added at 1:100 dilution. After 2 h of incubation, three washing steps with PBS-T were performed to remove any unbound antibody. A second incubation period followed, and 100 μl of optimally diluted (1:1000) anti-human immunoglobulin G (IgG)-alkaline phosphatase conjugated antibody (Sigma) was added for 1 h at 37°C. Plates were washed four times in PBS-T before 200 μl of p-nitrophenylphosphate (SIGMA FAST™ pNPP tablets Sigma-Aldrich) substrate for alkaline phosphatase (AP) enzyme was added to each well. Plates were incubated at 37°C in the dark until color developed and were read at 405 nm by using a VERSATunable Max microplate reader (Molecular Devices, USA). As a positive control, a T1DM patient's serum sample (No. 14) [11], which was previously found positive for MAP PCR and in ELISA assays for all the three antigens tested (HbHA, Gsd and MAP lysate) was included in each plate. Since Gsd was fused with the affinity tag Maltose binding protein (MBP), sera were tested with the LacZ-MBP control to evaluate a possible seroreactivity. Statistical analysis was performed by the Chi-square test with Yates' correction, P values were calculated using the online Graph Pad scientific calculator, http://www.graphpad.com quickcalcs_ttest1.cfm)
Results and Discussion
Results of the MAP antigen and whole cell ELISA have been summarized in Figure 1. Overall, the ELISA values were not significant to unravel any relationship between MAP humoral response and the T2DM disease phenotype. This is in contrast to the observations made with T1DM cases where highly significant humoral immune responses to all the three antigens have been documented in the blood of subjects [11]. Also, T1DM patients were shown to harbour circulating loads of bacilli in their peripheral blood as revealed by IS900 based PCR assays [10]. The outcome of the IS900 based PCR assay in our T2DM subjects were also insignificant as seen in case of ELISA. This negates the possibility of a MAP bacteremia in T2DM patients.
MAP is a multi-host pathogen with a broadest host range comprising of many birds, animals and primates [14]. It persists within the human gut in a Ziehl-Neelsen negative "cell wall deficient form" [1, 13] which could be the potential source of antigens in the host that may direct auto-immune responses. Deficiency of vitamin D has been implicated as a risk factor for T1DM [8] and T2DM (where vitamin D and calcium insufficiency may negatively influence glycemia), whereas combined supplementation with both the micronutrients may be beneficial in optimizing glucose metabolism [3]. Recently, Vitamin D has been reported to be involved in upregulation of an antimicrobial peptide thus limiting the mycobacterial infections [15]. Such studies possibly help linking the two diseases, diabetes and Crohn's, where MAP could be the common agent putatively behaving as environmental trigger of auto-immunity.
T2DM was linked to mycobacteria as early as in 1943 by Hass and Huntington [16] and afterwards in 1964 [2] and by Schwartz in 1972 [17]. Since then there is a massive body of data that posed speculations on a possible mycobacterial involvement in diabetes [1, 8–12, 15]. Our results here unequivocally refute such speculations through a robust assay that used three different antigen preparations which were previously shown to be having acceptable sensitivity and specificity in case of T1DM.
In conclusion, we demonstrate that T2DM patients do not have significant levels of anti MAP antibodies in contrast to their T1DM counterparts. This seemingly hints at the possibility where the involvement of immune dysregulation caused by a persistent pathogen such as MAP (as hypothesized in case of Crohn's disease and T1DM) in T2DM becomes irrelevant as a possible mechanism. At the same time, our observations put at rest the long driven speculation on the involvement of a MAP infection as a trigger in type 2 diabetes.
Funding for the work was provided by the University of Sassari (60%) and Italian Miur (PRIN 2005). NA would like to thank Dept. of Biotechnology of the Government of India and CDFD for providing support to his laboratory.
Authors' Affiliations
- Dow CT: Paratuberculosis and Type I diabetes: is this the trigger?. Med Hypotheses. 2006, 67: 782-785. 10.1016/j.mehy.2006.04.029View ArticlePubMedGoogle Scholar
- Penner A, Crohn BB: Perianal fistulae as a complication of regional ileitis. Ann Surg. 1938, 108: 867-873. 10.1097/00000658-193811000-00007PubMed CentralView ArticlePubMedGoogle Scholar
- Pittas AG, Lau J, Hu FB, Dawson-Hughes B: The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007, 92: 2017-29. 10.1210/jc.2007-0298PubMed CentralView ArticlePubMedGoogle Scholar
- Toba M: The phagocytic activity of the leucocytes against the tubercle bacilli in diabetic patients. Kekkaku. 1954, 29: 86-91.PubMedGoogle Scholar
- Stumvoll M, Goldstein BJ, van Haeften TW: Type 2 diabetes: principles of pathogenesis and therapy. Lancet. 2005, 365: 1333-1346. 10.1016/S0140-6736(05)61032-XView ArticlePubMedGoogle Scholar
- Virally M, Blicklé JF, Girard J, Halimi S, Simon D, Guillausseau PJ: Type 2 diabetes mellitus: epidemiology, pathophysiology, unmet needs and therapeutical perspectives. Diabetes Metab. 2007, 33: 231-44. 10.1016/j.diabet.2007.07.001View ArticlePubMedGoogle Scholar
- Castell C, Tresserras R, Serra J, Goday A, Lloveras G, Salleras L: Prevalence of diabetes in Catalonia (Spain): an oral glucose tolerance test-based population study. Diab Res Clin Pract. 1999, 43: 33-40. 10.1016/S0168-8227(98)00125-9.View ArticleGoogle Scholar
- Knip M, Veijola R, Virtanen SM, Hyoty H, Vaarala O, Akerblom HK: Environmental triggers and determinants of type 1 diabetes. Diabetes. 2005, 54: 125-136. 10.2337/diabetes.54.suppl_2.S125View ArticleGoogle Scholar
- Weitgasser R, Lechleitner M, Koch T, Galvan G, Mühlmann J, Steiner K, Hoppichler F: Antibodies to heat-shock protein 65 and neopterin levels in patients with type 1 diabetes mellitus. Exp Clin Endocrinol Diabetes. 2003, 111: 127-31. 10.1055/s-2003-39784View ArticlePubMedGoogle Scholar
- Sechi LA, Paccagnini D, Salza S, Pacifico A, Ahmed N, Zanetti S: Mycobacterium avium subsp. paratuberculosis bacteraemia in Type-1 diabetes cases: An infectious trigger?. Clin Inf Dis. 2008, 46: 148-149. 10.1086/524084.View ArticleGoogle Scholar
- Sechi LA, Rosu V, Pacifico A, Fadd Ga, Ahmed N, Zanetti S: Humoral immune responses of Type-1 Diabetes patients to M. avium subspecies paratuberculosis lend support to the infectious trigger hypothesis. Clin Vaccine Immunol. 2008, 15 (2): 315-26.View ArticleGoogle Scholar
- Child DF, William CPs, Jones RP, Hudson PR, Jones M, Smith CJ: Heat shock protein studies in type 1 and type 2 diabetes and human islet cell culture. Diabetic Med. 1995, 12: 595-599.View ArticlePubMedGoogle Scholar
- Sechi LA, Ahmed N, Felis GE, Duprè I, Cannas C, Fadda G, Bua A, Zanetti S: Immunogenicity and cytoadherence of recombinant Heparin Binding Haemagglutinin (HBHA) of Mycobacterium avium subsp. paratuberculosis: Functional promiscuity or a role in virulence?. Vaccine. 2006, 24: 236-243. 10.1016/j.vaccine.2005.11.030View ArticlePubMedGoogle Scholar
- Rowe MT, Grant IR: Mycobacterium avium ssp. paratuberculosis and its potential survival tactics. Lett Appl Microbiol. 2006, 42: 305-311. 10.1111/j.1472-765X.2006.01873.xView ArticlePubMedGoogle Scholar
- Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zugel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL: Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006, 311: 1770-1773. 10.1126/science.1123933View ArticlePubMedGoogle Scholar
- Hass GM, Huntington R: Amyloid 111. The properties of amyloid deposits occurring in several species under diverse conditions. Archives of Pathology. 1943, 35: 226-241.Google Scholar
- Schwartz P: Amyloid degeneration and tuberculosis in the aged. Gerontologia. 1972, 18: 321-362.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Lincoln is our new stud boy, unrelated to our girls, we bought him when Joka failed his hip score. He was one of 15 puppies, and 1 of only two boys from the litter.
What to say about Linc, he's a total clown, so bouncy and energetic that everyone just gets out of his way when he is in full bounce. The bounces are mostly brought about by his dinner being ready, dinner is his favourite time of day!! He is ridiculously affectionate which is typical for most flatty boys, he just loves to have his chest tickled. He has learned that he must not jump up for a fuss…most of the time anyway!! He loves to splosh around on the beach and can't wait to get out and about on a walk.
Build wise, he is a completely different kettle of fish to Vincent, Vincent is an elegant, slim dog, whereas Lincoln is more of a chunk, he has a great length , a fantastic head and is a real big strong boy. He is unfortunately never still and that's why we can't get a decent photo of him for you to see!!
He loves all the girls and his first litter with Skye was a litter of 12 so it seems he might have inherited his mothers penchant for large families!!
Born 17/07/2013
Clear eye test
Hip Score 3:3
If you have any questions, queries or comments about our dogs, puppies, web site or Flatcoat Retrievers, please contact us by telephone or email.


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Make Your Cilantro And Parsley Last A Long Time
Parsley, cilantro, garlic, onions, ginger, and spring onions are crucial to my cooking and I always need to have some on hand. Fortunately, most of these are easy to store and have a long shelf life. However, if you don't handle your cilantro correctly it can turn into a slimy mess.
There are a variety of opinions about the best way to store cilantro. Some people recommend washing it and then wrapping it in a paper towel and placing it either a paper or plastic bag. Others recommend placing it in a glass of water in the refrigerator.
After experimenting with all of the approaches, my failsafe method is:
1. Select cilantro at the market which is nice and green and not very wet.
2. At home, remove any bad or damaged leaves.
3. Align the bottom of the stems, wrap them with a twisty tie or rubber band.
4. Cut a small amount off the bottom of the stems.
5. Place the unwashed cilantro in a glass of cold tap water (being careful that the leaves don't touch the water).
6. Place the cilantro and glass into a plastic produce bag and tie or band it closed.
7. Change the water each time when you use a bit of cilantro, or at least once a week.
Typically, you will just use a small portion of the cilantro at a time. Of course you will want to wash it before use. Also, any time that you have the cilantro open, discard any unattractive stems and leaves.
Debbie Meyer Green Bags work even better than plain plastic bags. The cilantro pictured was bought more than two weeks before I went on a 14 day cruise (so it went 15 days without changing the water and was still fresh enough to use).
This approach also will extend the life of parsley; I have had parsley remain usable for more than 8 weeks. This method would probably also work well with other herbs and spices (such as oregano, basil, mint, thyme, dill, etc.).
Note: Cilantro, Chinese Parsley, and Coriander Leaves are just different names for the same thing.
I hope that you find this useful.
Update On Mar 11, 2010: Chelation therapy is a treatment to remove heavy metals (such as lead) from the human system. Some people claim that Cilantro is a very good chelation agent.
Update On Mar 11, 2010: Chelation therapy is a treatment to remove heavy metals (such as lead) from the human system. Some people claim that Cilantro is a very good chelation agent.


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Courses for wheelchair users and those with limited mobility
Blokart World is keen to offer Blokart sailing to all and welcome those with limited mobility and wheelchair users to compete and have fun on an equal basis with their able bodied friends and competitors.
As the Blokart is hand steered and we have available 5 point harness which keeps the pilot secure in the kart even when it capsizes, makes it the perfect sport for all to take part in the true spirit of fair play.
If you are involved in a disability activity group and would like to talk to us about organising a course or fun day please contact us for further information.


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The trouble with truancy
Pyskool 0.5.1 has been released. The download page is the place to go to get a copy. 0.5.1 is a bugfix release. In 0.5 there is a bug that makes the game crash when the teacher has returned to the blackboard during a non-question-and-answer lesson after fetching the truant Eric; this bug is now fixed.… Read More »


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To get in touch with Munchkin League, contact our Program Coordinator:
Debbie Ryan
E: email@example.com
Follow us on:
Munchkin League is a new and exciting Early Childhood Physical Development Program. The program is designed specifically for 3-5 year olds, of all abilities and skills, and runs over 8 week blocks.
A philosophy of learning through play, promotes physical activity in a fun and interactive environment. Children are supported and encouraged by qualified Early Childhood educators.
Munchkin League engages children in learning fine and gross motor skills, problem solving abilities and communication and teamwork. The program supports social and emotional growth and assists children to develop independence, self-confidence and self-awareness. Munchkin League provides an opportunity for children to learn to respect others, try something new and make lots of new friends.


text: BodyMedia, Inc. was founded in 1999 and is the pioneer in developing wearable body monitoring systems designed to help people lose weight, improve performance, and live a healthier lifestyle. My work with BodyMedia involves developing and implementing site designs through the use of their internal system, NetSuite. I have worked with co-workers in developing templates, graphics, and overall site design allow for the best user experience. The majority of my work deals with CSS, HTML, JavaScript, and Ajax. I also develop PhotoShop designs into working websites.


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I'm going to be honest, I wasn't expecting Allegiant. I was fully expecting it to be called Convergent, because I thought that fit in well with the other titles, Divergent and Insurgent, but Allegiant it shall be! The book cover is being unveiled in a months time, and Allegiant will be released, as you can see above, on the 22nd October.
Who's excited for Allegiant (I know I am!). What do you think of the title? What do you think the cover will look like? So super excited for this!


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I wanted to lose weight before going on a trip with my friends, and decided that the best way to do it was by getting on a diet plan. I've heard some good things about the diet plans that exist today, but the two that seem to be the most favorable among people are the Jenny Craig and the Nutrisystem plans. When thinking about Jenny Craig vs Nutrisystem Diet as a diet plan for me, I focused on food options and price. I only had so much money to put toward a diet, especially with the trip coming up.
Between the two, Nutrisystem was the cheaper option. The cost of their diet basically fell to the cost of the food, as opposed to Jenny Craig, which included the cost of food along with a membership, enrollment and shipping fees. Continue reading A Body Ready for the Beach


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My name is Andrii Lundiak, and this is my 5th blog 🙂
#1 – [2010] Work'n'Me
– is dedicated only to my work as Web Developer. I created it time ago (2010) as 1st blog based on Blogger platform, but then migrated to WordPress (2013-Dec-28). I do post different topics in most cases in English language and related to web development, JavaScript and computers in general.
– is about my genealogical research of my family surname LUNDIAK (including etymology and DNA research). Mixed with research of history of Galicia and own village. Started on Blogger platform (2010) but then migrated to WordPress (2014-Jun-20).
#3 – [2012 ] N! думок
– This blog you reading is my 3nd blog I started in general, but it was first on wordpress platform (2012). It's about personal thoughts in different areas, such as: social thoughts, psychology, relationship, political, philosophy, religious views, some simple observations, year summaries, etc. I consider it as my main blog. Note: Initially I planned to continue working with Blogger platform, I've even created blog "Me Myself and I" ob blogspot, but no posts at all, so I deleted it. But in 2012 I finally decided to start wordpress blog.
#4 – [2014] PolyJazyk
– This is my 4th blog and it's dedicated to multilinguality, or in other words "how does it feel to be polyglot?" or "Have you tried to learn more languages u know?", "But why not? It's very interesting". In 2015 re-branded from "This Awesome English" to "Poly Jazyk".
#5 – [2016] Podorozhnyk
– It's about travels, different trips to different countries by different ways and transport, and obviously different goals But all tourism-related. Till 2016 year, I mixed turism-like articles with other posts on blog "N! Thoughts", but then I decided to divide my thoughts into dedicated blog.


text:
Kane, B (2013) 'Custom, Memory and Knowledge in the Late Medieval English Church Courts.' In: Hayes, R and Sheils, W J, eds. Clergy, Church and Society in England and Wales, c.1200-1800. Boydell and Brewer/York Medieval Press, York, pp. 61-81.
|Item Type:
|Book Chapter or Section
|D History General and Old World > D History (General)
|College of Liberal Arts
|Date Deposited:
|14 Nov 2013 11:38
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|29 Apr 2016 13:28
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Album review: Jason Derulo's self-titled debut
On three singles from Jason Derulo's self-titled debut album, he starts the song by enthusiastically crooning his own name. It's a pretty goofy thing for the young singer to do, but the third-person shout-out to himself makes a certain sense after taking in the whole record. Derulo tackles an array of earnest trance-pop, glossy guitar rock and buttoned-down R&B over the album's nine tracks. His reminders that a single artist is responsible are actually rather helpful.
Weirdly, the post-genre pastiche works. Derulo gets a strong songwriting assist from producer J.R. Rotem here -- one rarely waits more than a few seconds for something deliriously catchy to happen. He's a nimble vocalist who uses Auto-Tune the way T-Pain does -- as an accent to already sharp melodies like the churning "In My Head" or the fizzy disco-pop of "The Sky's the Limit." The Haitian American Derulo also knows exactly when to deploy his Caribbean lilt to ramp up a song's melodrama, and it's one of his best vocal tricks.
The veering eclecticism of the album suggests that he's still figuring out his sound though, and he won't have untilled Imogen Heap samples, like on the inescapable "Whatcha Say," to work off of forever. Nonetheless, it's a pleasure-packed debut, and Derulo's melismatic call sign should be pouring out of car windows for the duration of 2010.
-- August Brown
Jason Derulo
"Jason Derulo"
Beluga Heights/Warner Bros.
Two and a half stars (Out of four)


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The brainchild of Philadelphia native Annie Sachs, Tickley Feather creates scratchy bedroom probings that slot nicely next to fellow Paw Tracks alum Ariel Pink, yet she's not nearly as musically dynamic or engaging as the kingpins of her loose coterie, Animal Collective.
Tickley Feather's debut long-player opens with a small child's voice drawling, somewhat disconcertingly, "I've got magic inside my bones somewhere." Similar spoken snippets are scattered throughout the record, each centering around the words "bones" or "magic," or both. Clearly the repetition is intentional and well-considered, as you'd be hard-pressed to come up with two terms that better convey the essence of a skeletally lo-fi album that pulls its bliss from such improbable places.
The brainchild of Philadelphia resident Annie Sachs, Tickley Feather's scratchy bedroom probings slot nicely next to fellow Paw Tracks alum Ariel Pink, yet (as is the case with Pink), she's not nearly as musically dynamic or engaging as the kingpins of her loose coterie, Animal Collective. The song title "Keyboards Is Drunk" is a succinct summation of Sachs' approach (she's clearly quite fond of straightforward nomenclature-- see also titles like "Rain Bucket" and "Leaking Roof"), as she utilizes wobbly, simplistic key patterns and layers them with largely indecipherable singsong melodies or chirpy yells, occasionally a low-rent drum track, and other sonic detritus. This is the kind of record where hiss, feedback, and even the abstract concepts of cheapness and obfuscation are more or less instruments as well, coloring and shaping what we hear, burying certain motifs while embellishing others.
Given her deliberately limited palette, it makes sense that Sachs' tracks would start to sound a bit same-y, with their abbreviated running times admittedly a saving grace, as even three and a half minutes of "Night Train" interminably attests. Still, there are plenty of standouts here, haunting or earworm-ish moments like the "tra la la"s of "Le Daylight" or the relatively long, smudgy vocal lines that sprout into melodies on "The Python" and "Night Chant". As you'd expect, even minor departures from the blueprint stand out, with magnified thrills arising from the booming "Psycho Killer" bass of "Sorry Party" and the harsher electro edge of "Tonight Is the Nite" (both of which also find Sachs yelling more than usual). As a standalone artifact Tickley Feather has plenty of charm, yielding something furtive but friendly for those who penetrate its mountains of artlessness and hiss. However, the jury's still out on whether there's enough here to build a sustainable and rewarding aesthetic.


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Every aspect of Arab culture is vividly portrayed and implemented into Arab City Malacca. Strict attention to detail has been paid – from the lighting, interior design, product placement to employees wearing traditional costumes, in bringing an assurance to visitors that they will be treated to a true reflection of Arab life, its culture and the warm hospitality that naturally comes with it.
Its Museum, which is the first of its kind in South East Asia to house Egyptian antiquities, makes Arab City Malacca a stand-alone destination. Other unique attractions like its man-made lagoon with full water sports facilities are draws guaranteed to enthrall and entice visitors to stay for the day and return over and over again.
Arab City Malacca also encompasses many Arab inspired bazaars and a dazzling array of ambient restaurants among the many facilities for visitors to discover and relish within its compound.The bazaars are laden with wares from jewelry to fabrics sourced from Algeria to Yemen. Restaurants serve authentic regional Arab cuisine with herbs and spices that create a distinct aroma and taste to give you a memorable dining experience. The perfumes and oils of the spa exclusively for men and women are brought in from Egypt and Tunisia.


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Good news! We're launching a new Google Chrome extension called Unseenly which can hide or disable seen feature on both Facebook Chat and Messenger for web. This Unseenly app for chrome is all you need for Facebook chat privacy while you chat your friends or family members. So what exactly is Facebook Unseenly Chrome extension? What will this Unseenly Facebook app
So what exactly is Facebook Unseenly Chrome extension? What will this Unseenly Facebook app do? Let's drive deep to know completely about Facebook unseen Chrome extension.
Why Facebook Unseenly Google Chrome Extension
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You can not lie to them that you didn't see the message. Because of this issue, many relations are getting spoiled and a lot of misunderstandings developed between good friends and lovers.
To save people from this situation we developed a Google Chrome extension called Facebook Unseenly which can disable this killer "Seen" feature in Facebook chat and messenger.
All you have to do it just installing this Unseenly Chrome extension and you are good to go.
Features of Facebook Unseenly Chrome Extension
Unseenly Facebook extension is very simple and straightforward. We have provided a link to get Unseenly app for chrome at the end of the article and you need to go the Chrome web store using that link to download the Unseenly Chrome extension.
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No product in the world is perfect. Almost all products will have minor to major bugs which should be ignored by the user to enjoy the remaining awesome features. In the same way, even Unseenly Facebook Chrome extension also had one minor bug.
The bug is, after installing the Unseenly extension, even after reading your messages, Facebook will show them as unread. You need to manually mark them as read if you want to do it.
This is the only known bug so far we identified and also we're working very hard to develop mobile apps for Android, iOS and Windows to disable seen feature in Facebook chat.
Currently, Unseenly Facebook extension is not available for Firefox and we'll try to release it very soon.
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We're maintaining the detailed changelog with dates for Unseenly app Chrome extension to help our user to know about the changes and the latest version of Unseenly app extension.
This Unseenly Facebook Chrome extension is mainly developed to protect Facebook chat privacy and we took extreme measures to make Unseenly extension bug free.
Download and Install Facebook Unseen Chrome Extension [Free]
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Hope you like our Facebook Unseenly extension and it helps you in protecting Facebook chat privacy and save your relationships. If you like our Unseenly Facebook Google Chrome extension, don't forget to rate 5 stars in the web store and also if you have any feedback/question/bugs about Unseenly app then do drop a comment below and we'll try our best to fix Unseenly Chrome extension.


text:
- Short report
- Open Access
Pain-related anxiety-like behavior requires CRF1 receptors in the amygdala
- Guangchen Ji1,
- Yu Fu1,
- Katherine A Ruppert1 and
- Volker Neugebauer1Email author
© Ji et al; licensee BioMed Central Ltd. 2007
- Received: 10 May 2007
- Accepted: 05 June 2007
- Published: 05 June 2007
Corticotropin-releasing factor receptor CRF1 has been implicated in the neurobiological mechanisms of anxiety and depression. The amygdala plays an important role in affective states and disorders such as anxiety and depression. The amygdala is also emerging as a neural substrate of pain affect. However, the involvement of the amygdala in the interaction of pain and anxiety remains to be determined. This study tested the hypothesis that CRF1 receptors in the amygdala are critically involved in pain-related anxiety. Anxiety-like behavior was determined in adult male rats using the elevated plus maze (EPM) test. The open-arm preference (ratio of open arm entries to the total number of entries) was measured. Nocifensive behavior was assessed by measuring hindlimb withdrawal thresholds for noxious mechanical stimulation of the knee. Measurements were made in normal rats and in rats with arthritis induced in one knee by intraarticular injections of kaolin/carrageenan. A selective CRF1 receptor antagonist (NBI27914) or vehicle was administered systemically (i.p.) or into the central nucleus of the amygdala (CeA, by microdialysis). The arthritis group showed a decreased preference for the open arms in the EPM and decreased hindlimb withdrawal thresholds. Systemic or intraamygdalar (into the CeA) administration of NBI27914, but not vehicle, inhibited anxiety-like behavior and nocifensive pain responses, nearly reversing the arthritis pain-related changes. This study shows for the first time that CRF1 receptors in the amygdala contribute critically to pain-related anxiety-like behavior and nocifensive responses in a model of arthritic pain. The results are a direct demonstration that the clinically well-documented relationship between pain and anxiety involves the amygdala.
- Elevated Plus Maze
- CRF1 Receptor
- Elevated Plus Maze Test
- Arthritis Group
- CRF1 Receptor Antagonist
Pain, including arthritis pain, has a negative affective component and is closely related to anxiety and depression [1–3]. The neural pathways and mechanisms involved in pain-related anxiety remain to be determined, but the amygdala is known to play a key role in emotional-affective behavior and anxiety disorders [4–6]. Importantly, the amygdala is emerging as an important element of the brain network involved in the emotional-affective component of pain [7–11]. The amygdala is also believed to be a key substrate of the reciprocal relationship between pain and affective states and disorders such as anxiety [3, 10, 12, 13].
Our previous studies demonstrated central sensitization [14–19] and synaptic plasticity [14, 20–23] in the central nucleus of the amygdala (CeA) in the kaolin/carrageenan-induced arthritis pain model. The CeA integrates affect-related information from the fear-anxiety circuitry in the lateral-basolateral amygdala with purely nociceptive inputs from the spino-parabrachio-amygdaloid pain pathway [7, 9, 10]. Pain-related synaptic plasticity in the CeA has also been confirmed in a model of chronic neuropathic pain [24]. It has become clear now that reversal of pain-related plasticity by pharmacologic deactivation of the CeA decreases nocifensive and affective pain responses in animal models of arthritic pain [14, 25], visceral pain [26] and neuropathic pain [11] and in the prolonged phase of the formalin test [27].
The present study focused on the role of corticotropin-releasing factor receptor 1 (CRF1) in the CeA in pain-related anxiety. The CeA is a major site of extrahypothalamic expression of CRF and a key element of the extrahypothalamic circuits through which CRF contributes to anxiety-like behavior and affective disorders [28–32]. CRF1 receptors have emerged as drug targets for depression and anxiety disorders in preclinical studies [29–31, 33–36]. A CRF1 receptor antagonist has been used successfully in humans to reduce depression and anxiety scores [37, 38]. Finally, the presence of CRF-containing neurons in the parabrachial area [39] links the CRF system in the amygdala to the spino-parabrachio-amygdaloid pain pathway and implicates CRF in the transmission of nociceptive information to the amygdala.
The behavioral and pharmacological studies reported here tested the hypothesis that CRF1 receptors in the amygdala (CeA) are critically involved in pain-related anxiety-like behavior. Adult male Sprague-Dawley rats (250–350 g) were used. All experimental procedures were approved by the Institutional Animal Care and Use Committee (IACUC) at the University of Texas Medical Branch (UTMB) and conform to the guidelines of the International Association for the Study of Pain (IASP) and of the National Institutes of Health (NIH).
Next we determined the effects of a selective CRF1 receptor antagonist (5-chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-trichlorophenyl) amino-pyridine, NBI 27914 [43]; purchased from Tocris Bioscience, Ellisville, MO). NBI27014 was administered either systemically (intraperitoneally, i.p.) or locally into the amygdala (CeA) by microdialysis in rats with arthritis (Fig. 1B). For drug application by microdialysis a guide cannula was implanted stereotaxically on the dorsal margin of the CeA as previously described in detail using the following coordinates [14, 25]: 1.8–2.0 mm caudal to bregma, 4.0 mm lateral to midline, depth 7.0 mm. On the day of the experiment a microdialysis probe (CMA/Microdialysis 11; membrane diameter: 250 μm, membrane length: 2 mm) was inserted into the CeA through the guide cannula so that the probe protruded by 2 mm. The probe was connected to a Harvard infusion pump and perfused with ACSF (2 μl/min) for at least 1 h to establish equilibrium in the tissue.
Anxiety-like behavior was measured in 5 groups of rats to determine the role of CRF1 receptors: arthritic rats without any additional intervention; arthritic rats that received systemic administration of vehicle (saline); arthritic rats with systemic administration of NBI27014 (5 mg/kg, i.p.); arthritic rats with vehicle (ACSF) administration into the CeA; and arthritic rats with intra-CeA administration of NBI27014 (100 μM; concentration in microdialysis probe which is 100-fold that predicted to be needed based on data from our previous studies [15]). The open-arm preferences of arthritic rats without any interventions (n = 6) and of arthritis rats with systemic saline (n = 5) or intra-amygdala ACSF (n = 5) were not significantly different (P > 0.05, Newman-Keuls Multiple Comparison Test; GraphPad Prism software 3.0; Fig. 1B). Systemic application of NBI27914 30 min before the EPM test in increased the open-arm preference significantly (n = 5; P < 0.05, compared to saline group; Newman-Keuls Multiple Comparison Test). Administration of NBI27914 into the CeA for 30 min also increased the open-arm preference significantly (n = 5; P < 0.05, compared to ACSF control group; Newman-Keuls Multiple Comparison Test). The effects of systemic and intra-CeA administration of NBI27914 were not significantly different (P > 0.05; Newman-Keuls Multiple Comparison Test), suggesting that CRF1 receptors in the amygdala (CeA) account for the anxiolytic effect of CRF1 receptor antagonists.
In summary, this study showed that systemic or intra-amygdalar administration of a CRF1 receptor antagonist decreased anxiety-like behavior and nocifensive reflex responses in a model of arthritis pain, suggesting a key role of CRF1 receptors in the amygdala (CeA) in the modulation of pain-related anxiety. The novelty of this study is that it directly links the amygdala, through CRF1 receptors in the CeA, to pain-related anxiety, which is clinically well-documented but mechanistically not well understood.
Although the amygdala is known to play a key role in anxiety-like behavior through mechanisms that appear to involve CRF [28–32, 44], its contribution to pain-related anxiety remains to be determined. Recent biochemical [45–47] and behavioral [48–51] studies point to the amygdala as an important site for the pain-modulatory effects of CRF. Increased expression of CRF1 receptor mRNA was detected in the amygdala in a model of somato-visceral pain induced by intra-peritoneal acetic acid [46]. CRF mRNA increased in the CeA in models of colitis pain [45] and chronic neuropathic pain [47]. Intracerebroventricular or intra-CeA administration of a broad-spectrum CRF receptor antagonist (alpha-hCRF9-41) had antinociceptive effects on hyperalgesic behavior associated with opiate withdrawal [50]. Systemic administration of a CRF1 receptor antagonist nearly reversed colon hypersensitivity (visceromotor response) induced by stereotaxic delivery of corticosterone to the CeA [49]. On the other hand, intra-CeA administration of a non-selective CRF receptor antagonist (alpha-hCRF9-41) produced hyperalgesic behavior (decreased mechanical and thermal withdrawal thresholds) and attenuated the antinociceptive effects of CRF administered into the CeA in normal animals [48]. The reason for these conflicting findings is unclear at this time. Our recent electrophysiological data show that administration of a CRF1 receptor antagonist (NBI27914) into the CeA clearly inhibits the sensitization of CeA neurons in the arthritis pain model. Taken together with the present study, these findings suggest that CRF1 receptors critically contribute to pain-related sensitization that results in increased pain responses and anxiety-like behavior.
This work was supported by NIH grants NS38261 and NS11255.
Authors' Affiliations
- Gallagher RM, Verma S: Mood and anxiety disorders in chronic pain. Progress in Pain Res and Management 2004, 27: 139–178.Google Scholar
- Grachev ID, Fredickson BE, Apkarian AV: Dissociating anxiety from pain: mapping the neuronal marker N-acetyl aspartate to perception distinguishes closely interrelated characteristics of chronic pain. Mol Psychiatry 2001, 6: 256–258. 10.1038/sj.mp.4000834PubMedView ArticleGoogle Scholar
- Rhudy JL, Meagher MW: Negative affect: effects on an evaluative measure of human pain. Pain 2003, 104: 617–626. 10.1016/S0304-3959(03)00119-2PubMedView ArticleGoogle Scholar
- Maren S: Synaptic Mechanisms of Associative Memory in the Amygdala. Neuron 2005, 47: 783–786. 10.1016/j.neuron.2005.08.009PubMedView ArticleGoogle Scholar
- Kalin NH, Shelton SE, Davidson RJ: The Role of the Central Nucleus of the Amygdala in Mediating Fear and Anxiety in the Primate. J Neurosci 2004, 24: 5506–5515. 10.1523/JNEUROSCI.0292-04.2004PubMedView ArticleGoogle Scholar
- Phelps EA, Ledoux JE: Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior. Neuron 2005, 48: 175–187. 10.1016/j.neuron.2005.09.025PubMedView ArticleGoogle Scholar
- Neugebauer V, Li W, Bird GC, Han JS: The amygdala and persistent pain. The Neuroscientist 2004, 10: 221–234. 10.1177/1073858403261077PubMedView ArticleGoogle Scholar
- Baliki MN, Chialvo DR, Geha PY, Levy RM, Harden RN, Parrish TB, Apkarian AV: Chronic Pain and the Emotional Brain: Specific Brain Activity Associated with Spontaneous Fluctuations of Intensity of Chronic Back Pain. J Neurosci 2006, 26: 12165–12173. 10.1523/JNEUROSCI.3576-06.2006PubMed CentralPubMedView ArticleGoogle Scholar
- Gauriau C, Bernard JF: Pain pathways and parabrachial circuits in the rat. Exp Physiol 2002, 87: 251–258. 10.1113/eph8702357PubMedView ArticleGoogle Scholar
- Neugebauer V: Subcortical processing of nociceptive information: basal ganglia and amygdala. In Handbook of Clinical Neurology. Volume 81. Edited by: Cervero F and Jensen TS. Amsterdam, Elsevier; 2006:141–158.Google Scholar
- Pedersen LH, Scheel-Kruger J, Blackburn-Munro G: Amygdala GABA-A receptor involvement in mediating sensory-discriminative and affective-motivational pain responses in a rat model of peripheral nerve injury. Pain 2007, 127: 17–26. 10.1016/j.pain.2006.06.036PubMedView ArticleGoogle Scholar
- Heinricher MM, McGaraughty S: Pain-modulating neurons and behavioral state. In Handbook of Behavioral State Control. Edited by: Lydic R and Baghdoyan HA. New York, CRC Press; 1999:487–503.Google Scholar
- Fields H: State-dependent opioid control of pain. Nat Rev Neurosci 2004, 5: 565–575. 10.1038/nrn1431PubMedView ArticleGoogle Scholar
- Han JS, Li W, Neugebauer V: Critical role of calcitonin gene-related peptide 1 receptors in the amygdala in synaptic plasticity and pain behavior. J Neurosci 2005, 25: 10717–10728. 10.1523/JNEUROSCI.4112-05.2005PubMedView ArticleGoogle Scholar
- Ji G, Neugebauer V: Differential effects of CRF1 and CRF2 receptor antagonists on pain-related sensitization of neurons in the central nucleus of the amygdala. J Neurophysiol 2007.Google Scholar
- Li W, Neugebauer V: Differential roles of mGluR1 and mGluR5 in brief and prolonged nociceptive processing in central amygdala neurons. J Neurophysiol 2004, 91: 13–24. 10.1152/jn.00485.2003PubMedView ArticleGoogle Scholar
- Li W, Neugebauer V: Block of NMDA and non-NMDA receptor activation results in reduced background and evoked activity of central amygdala neurons in a model of arthritic pain. Pain 2004, 110: 112–122. 10.1016/j.pain.2004.03.015PubMedView ArticleGoogle Scholar
- Li W, Neugebauer V: Differential changes of group II and group III mGluR function in central amygdala neurons in a model of arthritic pain. J Neurophysiol 2006, 96: 1803–1815. 10.1152/jn.00495.2006PubMedView ArticleGoogle Scholar
- Neugebauer V, Li W: Differential sensitization of amygdala neurons to afferent inputs in a model of arthritic pain. J Neurophysiol 2003, 89: 716–727. 10.1152/jn.00799.2002PubMedView ArticleGoogle Scholar
- Neugebauer V, Li W, Bird GC, Bhave G, Gereau RW: Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5. J Neurosci 2003, 23: 52–63.PubMedGoogle Scholar
- Bird GC, Lash LL, Han JS, Zou X, Willis WD, Neugebauer V: Protein kinase A-dependent enhanced NMDA receptor function in pain-related synaptic plasticity in rat amygdala neurones. J Physiol 2005, 564: 907–921. 10.1113/jphysiol.2005.084780PubMed CentralPubMedView ArticleGoogle Scholar
- Han JS, Bird GC, Neugebauer V: Enhanced group III mGluR-mediated inhibition of pain-related synaptic plasticity in the amygdala. Neuropharmacology 2004, 46: 918–926. 10.1016/j.neuropharm.2004.01.006PubMedView ArticleGoogle Scholar
- Han JS, Fu Y, Bird GC, Neugebauer V: Enhanced group II mGluR-mediated inhibition of pain-related synaptic plasticity in the amygdala. Mol Pain 2006, 2: 18. 10.1186/1744-8069-2-18PubMed CentralPubMedView ArticleGoogle Scholar
- Ikeda R, Takahashi Y, Inoue K, Kato F: NMDA receptor-independent synaptic plasticity in the central amygdala in the rat model of neuropathic pain. Pain 2007, 127: 161–172. 10.1016/j.pain.2006.09.003PubMedView ArticleGoogle Scholar
- Han JS, Neugebauer V: mGluR1 and mGluR5 antagonists in the amygdala inhibit different components of audible and ultrasonic vocalizations in a model of arthritic pain. Pain 2005, 113: 211–222. 10.1016/j.pain.2004.10.022PubMedView ArticleGoogle Scholar
- Tanimoto S, Nakagawa T, Yamauchi Y, Minami M, Satoh M: Differential contributions of the basolateral and central nuclei of the amygdala in the negative affective component of chemical somatic and visceral pains in rats. Eur J Neurosci 2003, 18: 2343–2350. 10.1046/j.1460-9568.2003.02952.xPubMedView ArticleGoogle Scholar
- Carrasquillo Y, Gereau RW: Activation of the extracellular signal-regulated kinase in the amygdala modulates pain perception. J Neurosci 2007, 27: 1543–1551. 10.1523/JNEUROSCI.3536-06.2007PubMedView ArticleGoogle Scholar
- Gray TS: Amygdaloid CRF pathways. Role in autonomic, neuroendocrine, and behavioral responses to stress. Ann N Y Acad Sci 1993, 697: 53–60. 10.1111/j.1749-6632.1993.tb49922.xPubMedView ArticleGoogle Scholar
- Bale TL, Vale WW: CRF and CRF receptors: role in stress responsivity and other behaviors. Annu Rev Pharmacol Toxicol 2004, 44: 525–557. 10.1146/annurev.pharmtox.44.101802.121410PubMedView ArticleGoogle Scholar
- Reul JM, Holsboer F: Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol 2002, 2: 23–33. 10.1016/S1471-4892(01)00117-5PubMedView ArticleGoogle Scholar
- Steckler T, Holsboer F: Corticotropin-releasing hormone receptor subtypes and emotion. Biological Psychiatry 1999, 46: 1480–1508. 10.1016/S0006-3223(99)00170-5PubMedView ArticleGoogle Scholar
- Asan E, Yilmazer-Hanke DM, Eliava M, Hantsch M, Lesch KP, Schmitt A: The Corticotropin-Releasing Factor (CRF)-system and monoaminergic afferents in the central amygdala: Investigations in different mouse strains and comparison with the rat. Neuroscience 2005, 131: 953–967.PubMedView ArticleGoogle Scholar
- Charney DS: Neuroanatomical circuits modulating fear and anxiety behaviors. Acta Psychiatr Scand Suppl 2003, 38–50. 10.1034/j.1600-0447.108.s417.3.xGoogle Scholar
- Takahashi LK: Role of CRF(1) and CRF(2) receptors in fear and anxiety. Neurosci Biobehav Rev 2001, 25: 627–636. 10.1016/S0149-7634(01)00046-XPubMedView ArticleGoogle Scholar
- Chalmers DT, Lovenberg TW, Grigoriadis DE, Behan DP, De Souza EB: Corticotrophin-releasing factor receptors: from molecular biology to drug design. Trends in Pharmacological Sciences 1996, 17: 166–172. 10.1016/0165-6147(96)81594-XPubMedView ArticleGoogle Scholar
- Dautzenberg FM, Hauger RL: The CRF peptide family and their receptors: yet more partners discovered. Trends Pharmacol Sci 2002, 23: 71–77. 10.1016/S0165-6147(02)01946-6PubMedView ArticleGoogle Scholar
- Kunzel HE, Ising M, Zobel AW, Nickel T, Ackl N, Sonntag A, Holsboer F, Uhr M: Treatment with a CRH-1-receptor antagonist (R121919) does not affect weight or plasma leptin concentration in patients with major depression. J Psychiatr Res 2005, 39: 173–177. 10.1016/j.jpsychires.2004.06.006PubMedView ArticleGoogle Scholar
- Zobel AW, Nickel T, Kunzel HE, Ackl N, Sonntag A, Ising M, Holsboer F: Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. J Psychiatr Res 2000, 34: 171–181. 10.1016/S0022-3956(00)00016-9PubMedView ArticleGoogle Scholar
- Merchenthaler I, Vigh S, Petrusz P, Schally AV: Immunocytochemical localization of corticotropin-releasing factor (CRF) in the rat brain. Am J Anat 1982, 165: 385–396. 10.1002/aja.1001650404PubMedView ArticleGoogle Scholar
- Olivier B, Miczek KA: Fear and anxiety: mechanisms, models, and molecules. In Psychopharmacology of animal behavior disorders. Edited by: Dodman N and Shuster I. Malden, MA, Blackwell Sciences; 1998:105–121.Google Scholar
- Han JS, Bird GC, Li W, Neugebauer V: Computerized analysis of audible and ultrasonic vocalizations of rats as a standardized measure of pain-related behavior. Neurosci Meth 2005, 141: 261–269. 10.1016/j.jneumeth.2004.07.005View ArticleGoogle Scholar
- Neugebauer V, Han JS, Adwanikar H, Fu Y, Ji G: Techniques for assessing knee joint pain in arthritis. Mol Pain 2007, 3: 8. 10.1186/1744-8069-3-8PubMed CentralPubMedView ArticleGoogle Scholar
- Chen C, Dagnino R Jr., De Souza EB, Grigoriadis DE, Huang CQ, Kim KI, Liu Z, Moran T, Webb TR, Whitten JP, Xie YF, McCarthy JR: Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists. J Med Chem 1996, 39: 4358–4360. 10.1021/jm960149ePubMedView ArticleGoogle Scholar
- Rainnie DG, Bergeron R, Sajdyk TJ, Patil M, Gehlert DR, Shekhar A: Corticotrophin releasing factor-induced synaptic plasticity in the amygdala translates stress into emotional disorders. J Neurosci 2004, 24: 3471–3479. 10.1523/JNEUROSCI.5740-03.2004PubMedView ArticleGoogle Scholar
- Greenwood-Van Meerveld B, Johnson AC, Schulkin J, Myers DA: Long-term expression of corticotropin-releasing factor (CRF) in the paraventricular nucleus of the hypothalamus in response to an acute colonic inflammation. Brain Research 2006, 1071: 91–96. 10.1016/j.brainres.2005.11.071PubMedView ArticleGoogle Scholar
- Sinniger V, Porcher C, Mouchet P, Juhem A, Bonaz B: c-fos and CRF receptor gene transcription in the brain of acetic acid-induced somato-visceral pain in rats. Pain 2004, 110: 738–750. 10.1016/j.pain.2004.05.014PubMedView ArticleGoogle Scholar
- Ulrich-Lai YM, Xie W, Meij JTA, Dolgas CM, Yu L, Herman JP: Limbic and HPA axis function in an animal model of chronic neuropathic pain. Physiology & Behavior 2006, 88: 67–76. 10.1016/j.physbeh.2006.03.012View ArticleGoogle Scholar
- Cui XY, Lundeberg T, Yu LC: Role of corticotropin-releasing factor and its receptor in nociceptive modulation in the central nucleus of amygdala in rats. Brain Research 2004, 995: 23–28. 10.1016/j.brainres.2003.09.050PubMedView ArticleGoogle Scholar
- Myers DA, Gibson M, Schulkin J, Greenwood Van-Meerveld B: Corticosterone implants to the amygdala and type 1 CRH receptor regulation: effects on behavior and colonic sensitivity. Behav Brain Res 2005, 161: 39–44. 10.1016/j.bbr.2005.03.001PubMedView ArticleGoogle Scholar
- McNally GP, Akil H: Role of corticotropin-releasing hormone in the amygdala and bed nucleus of the stria terminalis in the behavioral, pain modulatory, and endocrine consequences of opiate withdrawal. Neuroscience 2002, 112: 605–617. 10.1016/S0306-4522(02)00105-7PubMedView ArticleGoogle Scholar
- Lariviere WR, Melzack R: The role of corticotropin-releasing factor in pain and analgesia. Pain 2000, 84: 1–12. 10.1016/S0304-3959(99)00193-1PubMedView ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Network access control (NAC) has come a long way since 2006, when it was all the rage. Back then, there were competing standards from Microsoft, Cisco and the Trusted Computing Group vying for IT managers' attention. There were dozens of different products, claims and counterclaims that were hard to parse, let alone believe. Products were buggy and difficult to implement without a tremendous amount of cross-vendor integration.
A Look Back
I wrote a cover story for a print magazine in 2008 showcasing four IT managers and their experiences with various NAC products. When I reread this piece, I was struck by how little has changed. Networks are still protected on the macro level by keeping systems updated with the latest patches and satisfying compliance regulations. But I was also interested in how much had changed on a micro level and how homogeneous networks were back then. A network-attached printer was about as odd as things got.
That was then. NAC — and the networks themselves — have come a long way in the past decade or so. The products have improved, and the endpoint and network security landscape has become more complex. We now have lots of devices on our networks that don't look like PCs, or printers for that matter. That is where NAC can find a new niche.
Discovering a New Purpose for NAC
Over the past decade, access control vendors have been squeezed between mobile device management and intrusion detection products; trying to evolve in that space has been difficult. With all the issues around Internet of Things (IoT) botnet attacks and compromises over network-connected devices that don't look like traditional endpoints, NAC has found a new purpose. As IT managers look to stem this malware tide, they have rediscovered this well-aged tool.
NAC had its original purpose in hardening network access and filtering which endpoints could connect to the enterprise network. This is still valid, especially in situations where endpoints come in many shapes and sizes, making it difficult to apply protective agents.
Back when I was testing these kinds of products in 2015, I wrote for Network World that "today's NAC tools use a combination of probes including NMAP, WMI, Radius authentication, remote access to log files via SSH and SNMP queries and other clever ways." I marveled at how much information these tools could suss out from a mixed bag of endpoints, which is why they are now being considered for protecting networks against IoT-fueled botnets gone wild. It might be time to take a closer look at what NAC protections can provide.


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Minnesota & Wisconsin Real Estate
(612) 270-0492
I'm privileged to serve the Twin Cities Metro, greater Minnesota and Western Wisconsin Residential Real Estate Marketplace. The Twin Cities have been my home my entire life, so I know the marketplace very well.
As a Realtor since 2007, I leverage my business and Custom New Home Sales experience, education (B.A., Economics), technical, marketing, design and photography skills to deliver excellent results for my clients.
Let's connect today to discuss how I can help you reach your Real Estate goals in this dynamic marketplace.
Give me a call at (612) 270-0492 or send me an email firstname.lastname@example.com. Thank you!
Pre-Market Research
Staging Consultation
Professional Photography
Digital & Print Marketing
MLS & Reverse Prospecting
Sales Negotiations
Net Proceeds Estimates
Closing Coordination
Agent License #40056471
Broker License #40344433


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UPF 50+ The Sun Tripper Cap offers effective sun protection performance in stylish urban fashion. A great sun hat to introduce your teens to the important concept of sun protection! This cap is for the young - and the young-at-heart. The convenient, foldable bill/visor allows for…
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The Diamond Shaped Roofing Shingle - Now with Scotchgard™ Protector!!
That's right! Our patented diamond-shaped shingle now comes standard with Scotchgard Protector™ to help prevent black streaks caused by blue-green algae!
Enjoy the distinct beauty of a diamond-shaped shingle for your home without compromise. For the life of your roof, this algae resistant shingle will retain its look and color while also protecting against the most extreme weather conditions. Art-Loc® Shingles with Scotchgard™ Protector help a roof maintain its aesthetic appearance by resisting the black streaks caused by algae, enhancing the home's overall visual appeal. Diamond-shaped shingles are your roof's best friend.
While our patented 2nd Century Art-Loc® diamond-shaped roofing shingles are great for new construction, its unique interlocking design makes it ideal for re-roof applications. Installing Art-Loc® directly over your existing roof saves time, saves money and spares you the stress of a messy roof tear-off.
Class IV Rated Diamond-Shaped Shingle
How can Sherriff-Goslin guarantee the resilience of every Art-Loc® roof we install? To get a better idea of their stability, it's good to know that roofing shingles are ranked into four classes based on their strength and overall durability. Class 1 is the least durable and Class 4 is the most resistant to damage. With this clarification, our customers can have peace of mind as Art-Loc® shingles are defined by Class 4 certification as they uphold the highest standards when it comes to protecting a home. Keep in mind, Class 4 shingles are not only important from a protection standpoint. Impact resistant shingles such as Art-Loc® also lend their value to curb appeal by preserving the integrity of the roof's looks as well.
While toughness is a distinct character trait of the Art-Loc® roof, the one soft spot you will find with Sherriff-Goslin is our relationship with our local community. We take pride in building a better shingle, because in turn we know it will help build a better community. This has been our mission for over a hundred years and we look forward to continuing this family tradition for years to come. So it is our pleasure to bring you the strength and stability your family needs, and we look forward to speaking with you soon. Get a FREE estimate and request a quote today!
Art-Loc Roofing Shingle Features and Benefits
Durability in every Art-Loc® Shingle
During the manufacturing process, SBS bonds to oils in the asphalt creating an elastic network that gives Art-Loc® shingles unprecedented flexibility, durability and water resistance.
The Impact Resistance of Diamond-Shaped Shingles
Art-Loc® shingles meet the coveted UL Class 4 Impact rating. This means Art-Loc® shingles reduce the damage caused from hail.
Algae Resistance
Art-Loc® Shingles with Scotchgard™ Protector help a roof maintain its aesthetic appearance by resisting the black streaks caused by algae, enhancing the home's overall visual appeal.
Fire Resistance
Art-Loc® meets the highest standards in fire resistance and requires passing an intermittent flame test, a flame spread test, & a burning brand test.
Wind Resistance
Art-Loc® shingles combine strength and durability to withstand winds and rain up to 110 mph. This means fewer repairs and an attractive shingle for the lifetime of your roof.
The Sherriff-Goslin 10 Year Guarantee
As if a 30-year manufacturer's limited warranty wasn't enough, we also include an exclusive 10 Year Free Service Guarantee against leaks. Don't wonder if your new roof is guaranteed— know it is with Sherriff-Goslin.


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SUBLIMINAL PROJECTS is pleased to announce an exhibition of artwork by Dee Dee Ramone. The exhibition commemorates the 10th Anniversary of Dee Dee's death and celebrates the influence of this enigmatic rock icon and his valuable contribution to the punk rock movement.
Dee Dee was best known as the bassist, songwriter, and one of the founding members of the legendary American punk rock band, the Ramones. His sincere love for the visual arts and his boundless imagination inspired an ongoing series of paintings he created throughout his lifetime. These paintings are described by those who were close with the artist as highly reflective of his personality through their rebellious, dynamic, eccentric, and comedic aesthetic.
For this memorial exhibition, SUBLIMINAL PROJECTS has teamed up with the artist's estate to present a substantive body of Dee Dee's original work, on display for the first time in North America. These rare paintings were recently recovered on behalf of Dee Dee's Estate after years of passion, persistence and determination. Collected in an effort to preserve Dee Dee's multifaceted legacy, these works will now be on view to the public, providing a window into the identity, artistic talents, and unique persona of the legendary Dee Dee Ramone.
SUBLIMINAL PROJECTS presents
Exhibition Dates: October 27 – November 17
DEE DEE RAMONE: A Memorial Exhibition
Opening Reception: Friday, October 26 from 8pm–11pm


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Here's a mini round-up of some of the top-viewed posts from 2012! (Click image for original post!)
The following are a few of my personal favorites from the past year:
- Fresh Ginger Iced Tea
- Creature Swap
- Sapelo Island
- Anhinga Embroidery (I ended up removing him from the shop because I loved this piece too much to let it go!!)
- We Walked with Dinosaurs
If you have a blog, link me to some of YOUR top posts from 2012 – I'd love to read them!!


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can I call activex control developed in VB/VC in java using JNI? Is it possible to call activex control developed in VB/VC from JAVA and if yes how?
Created May 7, 2012
Luigi Viggiano Yes, it's possible: Bridge2Java (from IBM alphaWorks) allows Java programs to communicate easily with ActiveX objects, using the JNI and COM technology. Bridge2Java makes ActiveX objects to happen like Java objects.
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Our highway defect attorney recently filed a lawsuit against the City of Livonia for our 31-year-old client who suffered serious injuries in a motor bike accident. Our client was riding his mini-bike along West Field Street near Oxbow Street when he hit a dangerous condition in the roadway, being a broken and jagged/pothole area of concrete.
Michigan law provides that each governmental agency having jurisdiction over a highway shall maintain the highway in reasonable repair so that it is reasonably safe and convenient for public travel. The person who sustains bodily injury or damage to his or her property by reason of failure of a governmental agency to keep a highway under its jurisdiction in reasonable repair and in a condition reasonably safe and fit for travel may recover the damages suffered by him or her from the governmental agency.
Due to the unsafe road condition, our client suffered several serious injuries including a fractured clavicle. He required an open reduction surgery to repair the injury and was cleared to use his arm as tolerated five (5) months after the accident. He has chronic pain and has a residual scar from the surgery. There are also unpaid medical expenses which were incurred for treatment related to the accident.
The highway defect lawsuit seeks damage for the pain and suffering, disability, scarring, other personal injury damages, and unpaid medical expenses caused by the pothole. The case was filed in Wayne County Circuit Court in Detroit, Michigan. No trial date has been set by the Court.
For more information about your rights after a motor bike accident caused by a pothole or dangerous roadway, call our top rated Michigan highway defect attorneys today. If you have spent any time in Michigan, you know that potholes are unfortunately a very common occurrence on our roads. There is no question that the Government is responsible for maintaining roadways in reasonable repair. Therefore if you or someone you know was injured in accident that was caused by an unsafe condition, call our award winning office now at (800) 606-1717. We will explain your rights to you and start working on your case immediately, gathering all the evidence and witness statements to prove and win your injury claim.


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Alford Community Campus was officially opened yesterday by famous ex-pupil Emeli Sande, who performed alongside the school choir.
At the opening ceremony, Emeli unveiled a plaque alongside Aberdeenshire Provost Hamish Bernal, in front of an audience of pupils, councillors, and representatives from Morrison Construction.
School pupils gave a performance of 'Music Through the Decades', then Emeli performed her hit 'Read All About it', and then welcomed the school choir to accompany her singing 'Next to Me'.
The singer said it was an honour to be welcomed back to the school and added that she thought the new facilities were amazing and would really encourage creativity.
Emeli also donated a baby grand piano to the school, and Alford Academy head teacher Moira Milne said the school was touched and that Christmas had come early for Alford.
Alford Community Campus opened to the public in October and so far over 3,000 residents have used the facilities, including a library, theatre, dance studio, sports halls, gym, community rooms and a swimming pool.
Provost Vernal said: "This is the latest campus to be unveiled in Aberdeenshire and brings education, leisure and cultural facilities together for the whole community to enjoy.
"I have been impressed with the standard of these facilities and I thank everyone involved in the project from development to delivery."
The £37 million campus caters for all pupils in early years, primary and secondary education.


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See also: Imam Jamil Abdullah Al-Amin
Al-Hajj Talib Abdur-Rashid has been the imam of the Mosque of Islamic Brotherhood, a Sunni house of worship in Harlem, New York, since 1989. The mosque's congregation was founded in the 1960s by followers of Malcolm X. Born a Baptist in Greensboro, North Carolina in 1951, Abdur-Rashid was raised in the South Bronx during the social tumult and racial tensions of the 1960s. "I was heavily influenced by pan-Africanism, by black nationalism, by the antiwar movement, all of it," he says. "And then, I became a Muslim at age 20. And it played a great role in my grasp of the social-justice dimension of Islam." In addition to his work with the Mosque of Islamic Brotherhood, Abdur-Rashid is also the Amir (leader) of the Harlem Shura, a coalition of seven Harlem mosques; he serves as a chaplain to incarcerated Muslims in the city and state prisons of New York; and he works as a counselor to Muslims living with AIDS and to Islamic victims of domestic violence. Abdur-Rashid is a board member or advisor to several interfaith organizations in New York City: A Partnership of Faith; the Bertram Beck Institute on Religion and Poverty; the Chancellors Interfaith Advisory Committee of the New York City Board of Education; Harlem Congregations for Community Improvement; the Interfaith Center of New York; and the Temple of Understanding.Strongly opposed to America's post-9/11 invasion of Afghanistan, Abdur-Rashid helped organize a September 22, 2001 anti-war demonstration in Times Square. On several other occasions, he galvanized members of his congregation for anti-war rallies against the 2003 U.S. invasion of Iraq as well, coordinating his protests with Al Sharpton's National Action Network. Condemning what he calls the recent "anti-Muslim backlash" in the United States, Abdur-Rashid is a member of the National Committee to Free Imam Jamil Abdullah Al-Amin (the former 1960s radical, H. Rap Brown). Abdur-Rashid is the host of a monthly Harlem-based radio program titled "Prophetic Echoes." He is also the author of the forthcoming books, Social Justice According to the Prophetic Paradigm, and Reclaimed Legacy: Muslim Indigenous and Immigrant Peoples and The History of Al-Islam in America. On December 1, 2005, Abdur-Rashid penned an article titled "The Pre-Columbian Presence of Muslim Africans in America Is No Myth," where he wrote: "[T]here is such a constantly growing, extensive body of ... evidence of Western and Northern African Muslim pre-Columbian American (and Caribbean) presence, that those who study the evidence and continue to deny the obvious, reveal themselves to be rooted in old, racist, European renditions of American history." Abdur-Rashid depicts these "Muslim explorers" as people who "came to the land of the Original Americans, met them, peacefully interacted with them, traded with them, inter-married with them, and perhaps even gave another relative handful of them da'wa" [invitation to the faith]. He contrasts their purportedly peaceful actions in North America with those of white Europeans who "stole" from the continent's "indigenous inhabitants" their "God-given custodial land -- the land of the 'Red Man.'" Whites, adds Abdur-Rashid, "committed genocide against [the continent's] true people, stole the 'Black Man' from Africa and brought him to the stolen land against his will, and … populated the land from Europe." Charging further that America has robbed native Africans and Muslims of their heritage, Abdur-Rashid writes: "Many of the people kidnapped to this country and sold into slavery were already Muslims. And then, we suffered psychic and blunt-force trauma to the head, and forgot everything, including who we are and what we are. We were told, 'Your name is not Ahmed, your name is Charlie. You don't worship Allah. You worship Jesus.' … Not only were there African Muslims who were here in America as explorers before Christopher Columbus, but a third of the African slaves who were brought here during the slave trade were Muslims."
Because he views the United States as a nation infested with all manner of injustice, Abdur-Rashid derides Americans' annual celebration of "so-called Thanksgiving." "When we look at the prosperity abundant in America for the past several years," he elaborates, "we realize that for one out of nine people, to be poor is not just a shame, it is also a sin. When we see the effects of unrepentant violence against poor people of color ..."
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The FDA is warning physicians and other health care professionals about potential risks associated with concomitant use(www.fda.gov) of protease inhibitors and certain statin drugs.
According to an FDA release, when taken together, protease inhibitors and statins may raise blood levels of statins and, at the same time, increase the risk for muscle injury, including rhabdomyolysis.
With that in mind, the FDA is recommending that physicians and other health care professionals closely follow drug label recommendations when prescribing protease inhibitors used to treat HIV or hepatitis C virus (HCV) infection for patients who use statins. The labels for HIV protease inhibitors and the affected statins have been updated to contain consistent information about the drug-drug interactions, as well as dosing recommendations for statins that may be coadministered safely with HIV or HCV protease inhibitors.
Data from several studies(www.fda.gov) that demonstrated the increased statin level and muscle injury risks spurred the FDA warning. According to the agency, because the results from one such study that involved concomitant administration of atorvastatin and lopinavir/ritonavir have not yet been validated, caution should be used when co-administering the drugs, and the "lowest necessary dose of atorvastatin" should be used.
With regard to lovastatin and simvastatin, the FDA said that "a literature review indicates that itraconazole, a strong CYP3A4 inhibitor, increases lovastatin exposure up to 20-fold" and appears to result in rhabdomyolysis. With that in mind, other CYP3A4 inhibitors, including HIV and HCV drugs, also are "expected to significantly increase lovastatin and simvastatin exposures."
The agency also noted that HIV protease inhibitor combinations lopinavir/ritonavir and atazanavir/ritonavir used with rosuvastatin increase exposure to that statin as much as threefold, prompting the FDA to recommend that "the dose of rosuvastatin should be limited to 10 mg."
The FDA is asking health care professionals and patients to report any adverse events related to the use of these products to its MedWatch Safety Information and Adverse Event Reporting Program(www.fda.gov).
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Christmas Gift Guide: Alternative Christmas Gifts For Any Budget
Hey my lovelies. I am so bloody excited. It's finally December and goodness knows how much I need this festive-feeling. I practically shit Christmas, and it is the time of the year when I feel the best. So today I thought I'd crack on with the festivities and write up my Christmas gift guide.
I adore gift giving. I end most nights at the moment scrolling through the internet searching for the perfect gifts for family and friends. Not forgetting that Christmas morning feeling, as all those presents sit happily wrapped under the tree, ready to be received by those special people.
So here is my gift guide. I've tried to be quick creative with this, as I often find gift guides say a lot of the same thing. I have also split it into three sections, a budget socking filler, middle-of-the-way gift and a extra special perfect pressie (which would be more expensive). I hope you like the post and that it gives you some ideas.
#1 Cosy nights in
There's nothing quite like some lovely fresh new pyjamas. I love receiving pjs at any time of year, so why not at the cosy comfort of Christmas. They'd be all ready for your post-lunch sleep. Moreover they're perfect for anyone- for any age/ gender. Mums, friends, brothers… you can't go wrong.
Stocking filler- A lovely PJ set. Top picks would be Primark, Asos and New Look. You could even add some bed socks for that special touch.
Gift- Wrapping together a PJ set, bed socks, a DVD/ book and bath bomb in a box, will give you the perfect night in. An excuse to take a well-deserved relax- how can you go wrong?
The perfect pressie- Go that one step further and promise that person a perfect night in. Pledge to buy the meal/ pizza, pamper bits (nails / face masks), a DVD and matching PJs. This would be a lovely idea for a friend, or a mum, where you have a girly night together.
#2 Beauty bits
Beauty gifts are always a nice treat. For all those moments in Boots when you just can't justify that £12 mascara, I always enjoy receiving beauty bits on Christmas.
Stocking filler- A beauty giftcard can never go wrong, such as Boots or Superdrug, as it allows your recipient to pick out whatever they want. An especially good idea if you're unsure of their tastes or colouring.
Gift- There are so many giftsets available these days- your world really is your oyster. From drugstore brands, like Rimmel, to more high-end like Charlotte Tilbury. If this is out of your price bracket, you could always treat them to that one special product- like their favourite Benefit mascara (my gran loves to get me this) or a Mac lippy.
The perfect pressie- I think a lovely idea would be to buy a makeup bag (there is so much choice here but I know Primark, Notonthehighstreet, Amazon and Boots have some great picks), and fill it up with goodies. You could pop in their go-to Collection concealer, a Benefit blush and a new Real Techniques brush. This way you can spend however much you want and create a one-off personal gift.
#3 Photos, photos, photos
Photo-gifts are always my favourite- so personal to give and receive. There is also so much choice when it comes down to it these days- you can get your photos printed on anything from a t-shirt to an edible marshmallow (who knew?!).
Stocking filler- Most photo printing brands, or places like Funky Pigeon or Moonpig, have some smashing under £15 photo gifts. I have done the photo mug so many times and still think it is just a brilliant present. You can also get phone cases, calenders- you name it.
Gift- As an avid scrapbooker, I also know the value of saving memories in your own special way. Last year I brought my sister a scrapbook package, with a scrapbook, photo paper, scrapbooking bits and bobs. I completed the first few pages of our memories, with photos from the past year. She loved this and it was so much fun to make for her. My top pics for scrapbook essentials are Hobbycraft, Amazon and Paperchase- places which all range in price (so perfect for any budget).
The perfect pressie- Photo books are just such a beautiful gift. Whether their 2016 instagrams, last 20 years in photos or simple holiday snaps, a photo book is a lovely way to give a personalised pressie this Christmas. I received a lovely book for my birthday, with photos and memories from my girl's trip to Spain this summer. It was a joy to open, and I love to flick through it to bring all the memories back- it's effectively a printed off scrapbook… made with love.
#4 The hobby box
When thinking of gift ideas, one of the first questions you result to is- what does {blank} love/enjoy? Often they've got that special hobby, which is a great to base your gift on. Or maybe you know/ or think there's something they'd like to get into.
Stocking filler- Perhaps you could make something (or a few bits) relating to their hobby. Pinterest is always my no.1 for great DIY ideas, but there will be soooo many online. If they like sewing, you could DIY a homemade pin cushion, or if they play drums, you could make a pouch to keep their drumsticks in. If you want to go down the fabric route, you've probably got a needle and thread in the house somewhere and ebay sell some really cheap fabric (by the meter).
Gift- A great idea could be to buy a stocking, as cheaply as you like (I know Poundland or Primark would have some bargains there) and fill it with gifts relating to the hobby. If they liked baking, for example, you could buy some sprinkles, an apron, cookie cutters or a cookbook. This way you can limit it to the price you want to spend, and shop around for some cheaper alternatives.
The perfect pressie- The ultimate hobby box could include absolutely anything related to their hobby. For example, for my Grampy who love golf, I would pack it with some new gold balls, a sports top and a book relating to golf/ a golfer. Then I'd buy a nice gift box, from somewhere like Homesense or Paperchase, and wrap it up all beautifully.
Thank you for reading my gift guide this year. I really loved making this post, creating the gifts and photographing it all. Let me know what you thought of the post, or if you have any favourite gifts within this! Thanks my lovelies,
Thank you for reading my gift guide this year. I really loved making this post, creating the gifts and photographing it all. Let me know what you thought of the post, or if you have any favourite gifts within this! Thanks my lovelies,


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We have flashes of warm balmy days, when Summer seems to be almost upon us, caressing us with sun, and light zephyrs of harmless, mild air.
We are lulled into false feelings of warmth, and the bite of further cold air comes as a shock, to remind us that the Seasons are fickle, with Spring perhaps the most fickle of all.
The almost irredescant greens, of the new bursting leaves on the deciduous trees, remind us that Summer will soon arrive.
The Jacarandas are curious, as their leaves turn yellow, and begin to fall, at this time of year, in seeming contradiction to the seasons. They are making way for the glorious display of blossom in the beginning of Summer, which here, in Oz, is in reality, November.
We do seem to be blessed with many purple/blue flowers at the start of Summer.
Since our Jacaranda
I do, however have pics of our wonderful Orange Clivea.
When we first redesigned our garden bank, I divided some of the Clivea clumps, and transplanted them a little further away from the trunk of the Maple.
They were slow to flower, and seemed to sulk a little, though they did still receive the blanket of comforting leaves, that the Maple provided.
They produce lovely red berries, which are quite beautiful in their own right. They glow, a scarlet red, and I have no idea if they are fertile or not.
At present we have some very happy succulents, which are in a neglected pot. They are flowering prolifically, and are quite lovely upon close inspection.
My favourite is the fern which has regenerated from the log banks of the garden. I know they don't flower, but I have a very soft spot for ferns.
Our back yard had become heavy with perfume, from the neighbour Jasmine, which is heavlily flowering. We also have a Port Wine Magnolia, which is flowering and perfuming the air, along with another shrub with a small white flower, which I have forgotten the name of, but the perfume is very sweet.
They do "Sparkle".
However, I fear I have developed an allergy to something, since I seem to be sneezing rather a lot!
Even the dogs, and the cat, are snorting and sniffing!
Leo Sayer, Orchard Road.


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The Museum Thieves. Those thieves could never calm down! Just when we think that it is quiet and peaceful since we haven't heard about some new robbery on TV, there is one new! The city museum has been robbed and the police are looking for the criminals that have done that. Actually it is about quite big robbery since many important objects belonging to many different cultures are missing like some objects from the Egyptian culture, the Roman Empire, old Greece, and many others.
The police came as quick as they could but unfortunately many this were missing at that time. The search started immediately, because the thieves still might be near and it is easier to find them in that case. After a certain period of searching, the police find the place where the thieves have hidden the precious loot. It is about one old abandoned factory where so many artifacts can be found! Amazing!
To help the police deal with those objects, work together with them by looking for the objects that are missing. In every level you get a list with the objects that are hidden and your job is to find all of those objects, in order to move into the next level and finish the complete game.