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World News
I laughed when I read the story that I gave Israel ultimatum to return Nnamdi Kanu – Lai Mohammed
Minister of Information, Alhaji Lai Mohammed, on Wednesday dismissed social media report that he gave Israel ultimatum over the reappearance of the leader of the Indigenous People of Biafra (IPOB), Nnamdi Kanu, in that country.
The IPOB leader, who was sighted in Israel last week, had pledged to return to Nigeria soon, after his unceremonious disappearance from the country for about 13 months.
The minister, who fielded questions from State House correspondents, said: "I was in London when I heard the story about Nnamdi Kanu surfacing in Israel. I was not in a position to make any statement.
"But before I knew it, within a few hours, I saw my picture with a story saying that I had actually given Israel ultimatum to return Nnamdi Kanu otherwise, we will send them missiles.
"I just laughed. It speaks to what we are talking about fake news because it is probably the biggest threat in the run-up to the elections.
"Having said that I have nothing more to add, to the issue of Nnamdi Kanu.''
According to him, the appropriate authorities in the country will speak on the issue at the appropriate time.
"At the appropriate time, the various authorities will make a statement about the issue of Kanu,'' he said.
It would be recalled that the Presidency had on Tuesday, October 23 dismissed the Kanu's outburst and assured all Nigerians that there was no reason to worry about the hollow outburst by the IPOB leader.
Malam Garba Shehu, the Senior Special Assistant to the President on Media and Publicity, who gave the assurance in a statement in Abuja, restated that Nigeria under President Muhammadu Buhari was strong enough to defend its territory against any threat.
He said: "Instead, we see the re-enactment of his bizarre, episodic threat as a mere distraction which will not be allowed to detract from the existing cordial relationships between Nigeria and other countries.''
According to him, the Buhari administration is in constant touch with other friendly nations and has the best assurances that they would continue to reciprocate the respect Nigeria has for the sovereignty of their nations.
Saudi shuts Riyadh, Mecca, Medina after second coronavirus death
Saudi Arabia on Wednesday sealed off the capital Riyadh and two of Islam's holiest cities and extended curfew hours as it reported its second death from the new coronavirus.
The kingdom barred entry and exit from Riyadh as well as Mecca and Medina and prohibited movement between all provinces, the official Saudi Press Agency reported, as the health ministry said the total number of infections spiked to 900.
Saudi Arabia, which has reported the highest number of infections in the Gulf, on Monday began implementing an 11-hour nationwide curfew — starting at 7 pm — to limit the spread of the deadly COVID-19 illness.
The curfew hours were brought forward to 3 pm in the three cities, SPA said citing measures approved by King Salman that will take effect from Thursday.
Authorities plan to implement the curfew for 21 days and have warned that transgressors will be fined 10,000 Saudi riyals ($2,663) and could face jail for repeated breaches.
The health ministry on Wednesday said a resident of Mecca was the second person to die from the disease in the kingdom.
The Arab world's biggest economy has also closed down cinemas, malls and restaurants, halted flights and suspended the year-round umrah pilgrimage as it steps up efforts to contain the virus.
King Salman warned last week of a "more difficult" fight ahead against the virus, as the kingdom faces the economic double blow of virus-led shutdowns and crashing oil prices.
The king will chair an emergency virtual summit of leaders from the Group of 20 major economies on Thursday to discuss a global response to the coronavirus pandemic.
Last week, the kingdom unveiled stimulus measures amounting to 120 billion riyals ($32 billion) to support businesses and said it plans to raise borrowing to 50 percent of gross domestic product (GDP).
Similar restrictions and stimulus measures have been reported by other countries in the Gulf, where more than 2,400 coronavirus infections have been reported so far.
Coronavirus: With 3,405 deaths, Italy overtakes China as worst-hit country
Italy has overtaken China as the country with the highest number of coronavirus deaths.
The death toll in the country now stands at 3,405, overtaking China which has recorded 3,245 deaths from the virus since its outbreak in December.
Earlier, the Chinese authorities announced that Wuhan, where the disease broke out, and its surrounding province have no new cases while most of the patients are recovering.
On Wednesday, Italy recorded 475 deaths, the highest single-day increase since the first recorded case in February.
According to the Civil Protection Agency, the total number of cases in Italy rose to 41,035 from a previous 35,713. It described it as a faster rate of growth seen over the last three days.
It, however, added that out of the number infected, 4,440 had fully recovered.
The death toll keeps increasing despite a lockdown in the entire northern region which is the worst-hit. It has a population of about 16 million.
Morgues in Italy are reportedly working round the clock and overwhelmed as the number of deaths increases while doctors have said the country is facing a "catastrophic situation".
About 2,600 medical workers are said to have been infected.
The confirmed cases around the world is over 229,917, while 9,386 patients have died and 86,254 recovered.
US Approves Chloroquine To Treat Coronavirus
The US has approved the anti-malarial drug chloroquine for use as a treatment against the new coronavirus, President Donald Trump said Thursday.
"We're going to be able to make that drug available almost immediately, and that's where the FDA (Food and Drug Administration) has been so great," Trump told reporters.
"They've gone through the approval process — it's been approved. They took it down from many, many months to immediate. So we're going to be able to make that drug available by prescription."
Credit: AFP
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Increased attacks by Boko Haram and inter-communal violence in Nigeria's "Middle Belt" region leave civilians at risk of mass atrocity crimes.
Multiple security threats continue to leave civilians in Nigeria at risk of mass atrocity crimes, including increased attacks by the armed extremist group Boko Haram and recurring inter-communal violence in the "Middle Belt" region.
Despite claims by the government that it had defeated Boko Haram, over the past year the armed extremist group and the so-called Islamic State in West Africa (ISWA) have intensified their attacks in the north-east of Nigeria. On 6 January at least 30 people were killed when an Improvised Explosive Device detonated in Gamboru, Borno State. Two days later, an attack by ISWA on the village of Monguno, Borno State, resulted in at least 20 soldiers being killed, 750 houses destroyed and 1,000 civilians displaced. In response to an increase in attacks since December 2019, the Nigerian military has forcibly displaced entire villages in the north-east and has reportedly arbitrarily detained individuals suspected of supporting armed extremist groups.
Since 2009 Boko Haram has pursued a violent campaign aimed at overthrowing Nigeria's secular government. According to UN Office for the Coordination of Humanitarian Affairs, 35,000 people have been killed since 2009 and 1.8 million remain internally displaced in Borno, Adamawa and Yobe states as a result of insecurity caused by Boko Haram. The International Committee of the Red Cross also reported that at least 22,000 people are still missing due to the decades-long conflict. In recent years Boko Haram's attacks have expanded into neighboring states in the Lake Chad Basin, killing and displacing civilians in Cameroon, Chad and Niger.
Conflict in Nigeria's "Middle Belt," rooted in historical grievances between herders and farming communities, has also escalated in recent years. According to Amnesty International, 3,641 people were killed in clashes between herders and farming communities between January 2016 and October 2018. Hundreds of people were also killed in clashes in Kaduna, Nassarawa and Adamawa states between February and April 2019. In an attempt to reduce violence, during June the government proposed a new program of so-called "rural grazing areas" to accommodate pastoralist groups and their livestock. Due to strong criticism, the project was indefinitely postponed.
Since 2019 Nigeria has also experienced an increase in armed banditry in Zamfara, Kaduna and Katsina states despite efforts by the security forces to neutralize such groups. On 1 March at least 50 people were killed when armed men stormed into the villages of Kerawa, Zareyawa and Minda in Kaduna State in retaliation for villagers allegedly assisting the army in operations. More than 60,000 people remain displaced as a result of banditry in Zamfara State.
Although the "Middle Belt" region has experienced recurring inter-communal violence, growing desertification has increased competition for resources. The loss of grazing land in the north has driven many ethnic Fulani herdsmen, who are mainly Muslim, southward into areas farmed by settled communities that are predominately Christian. Arms proliferation has helped make these conflicts more deadly.
Since 2018 Boko Haram and ISWA have grown in power and influence. Although the regional Multinational Joint Task Force (MNJTF) has made significant progress in confronting these groups, civilians remain at risk of terrorist attacks and identity-based violence. Civilians also face the threat of human rights abuses committed by the Nigerian security forces during counter-terrorism operations.
The government of Nigeria is struggling to uphold its responsibility to protect and needs ongoing support from the international community.
The regional MNJTF has led efforts to combat Boko Haram since 2015. On 19 August 2018 the UN Secretary-General called for "the international community to increase support to regional efforts in the fight against Boko Haram in the Lake Chad Basin."
In September 2019, during her visit to Nigeria, the UN Special Rapporteur on extrajudicial, summary or arbitrary executions condemned rising violence across Nigeria and a "lack of accountability" for perpetrators.
It is essential that the government of Nigeria addresses the root causes of inter-communal violence in the "Middle Belt" through socio-economic initiatives and political reforms that tackle land rights and poor governance. The government should work with local civil society to ameliorate long-standing grievances between herding and settled communities. Utilizing the Early Warning System of the Economic Community of West African States, the government should increase police and military deployments to vulnerable areas. The government should also implement its "National Policy on Climate Change and Response Strategy" and accelerate initiatives in regions affected by drought and desertification.
The Nigerian government should continue to support programs that strengthen local security and bolster the rule of law in areas where ISWA and Boko Haram attacks continue. Such efforts should address comprehensive security sector reform, including by incorporating international humanitarian and human rights law into all military and police training. The government and international community should increase efforts to prevent illicit arms being trafficked into Nigeria.
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Ralph Bunche Institute for International Studies
The Graduate Center, CUNY
365 Fifth Avenue, Suite 5203
New York, NY 10016-4309, USA

subset: commoncrawl


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An image-based, high-throughput screening assay for molecules that induce excess DNA replication in human cancer cells.
Zhu W, Lee CY, Johnson RL, Kouznetsova J, Huang R, DePamphilis ML
Mol. Cancer Res. , (9), 294-310, 2011.
Article Pubmed
Previous studies have shown DNA re-replication can be induced in cells derived from human cancers under conditions in which it is not possible for cells derived from normal tissues. Because DNA re-replication induces cell death, this strategy could be applied to the discovery of potential anticancer therapeutics. Therefore, an imaging assay amenable to high-throughput screening was developed that measures DNA replication in excess of four genomic equivalents in the nuclei of intact cells and indexes cell proliferation. This assay was validated by screening a library of 1,280 bioactive molecules on both normal and tumor-derived cells where it proved more sensitive than current methods for detecting excess DNA replication. This screen identified known inducers of excess DNA replication, such as inhibitors of microtubule dynamics, and novel compounds that induced excess DNA replication in both normal and cancer cells. In addition, two compounds were identified that induced excess DNA replication selectively in cancer cells and one that induced endocycles selectively in cancer cells. Thus, this assay provides a new approach to the discovery of compounds useful for investigating the regulation of genome duplication and for the treatment of cancer.
Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.
Marugan J, Zheng W, Motabar O, Southall N, Goldin E, Westbroek W, Stubblefield BK, Sidransky E, Aungst RA, Lea WA, Simeonov A, Leister W, Austin C
J. Med. Chem. , (54), 1033-58, 2011.
Article Pubmed
Gaucher disease is a lysosomal storage disorder (LSD) caused by deficiency in the enzyme glucocerebrosidase (GC). Small molecule chaperones of protein folding and translocation have been proposed as a promising therapeutic approach to this LSD. Most small molecule chaperones described in the literature contain an iminosugar scaffold. Here we present the discovery and evaluation of a new series of GC inhibitors with a quinazoline core. We demonstrate that this series can improve the translocation of GC to the lysosome in patient-derived cells. To optimize this chemical series, systematic synthetic modifications were performed and the SAR was evaluated and compared using three different readouts of compound activity: enzymatic inhibition, enzyme thermostabilization, and lysosomal translocation of GC.
"Creating hope" and other incentives for drug development for children.
Connor E, Cure Ramirez P
Sci Transl Med , (3), 66cm1, 2011.
Article Pubmed
Enhancing drug development for pediatric disease is a priority and a public responsibility. The Creating Hope Act of 2010 is important new proposed legislation that adds drugs and biologics for treating rare diseases in children to those for neglected tropical diseases as eligible for a priority review voucher from the U.S. Food and Drug Administration. The Act enhances existing incentive programs through specific financial benefits to companies who seek a pediatric indication for a new drug to treat an orphan disease that occurs specifically in children.
Cooperative epigenetic modulation by cancer amplicon genes.
Rui L, et al.
Cancer Cell , (18), 590-605, 2010.
Article Pubmed
Chromosome band 9p24 is frequently amplified in primary mediastinal B cell lymphoma (PMBL) and Hodgkin lymphoma (HL). To identify oncogenes in this amplicon, we screened an RNA interference library targeting amplicon genes and thereby identified JAK2 and the histone demethylase JMJD2C as essential genes in these lymphomas. Inhibition of JAK2 and JMJD2C cooperated in killing these lymphomas by decreasing tyrosine 41 phosphorylation and increasing lysine 9 trimethylation of histone H3, promoting heterochromatin formation. MYC, a major target of JAK2-mediated histone phosphorylation, was silenced after JAK2 and JMJD2C inhibition, with a corresponding increase in repressive chromatin. Hence, JAK2 and JMJD2C cooperatively remodel the PMBL and HL epigenome, offering a mechanistic rationale for the development of JAK2 and JMJD2C inhibitors in these diseases.
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.
King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai Bantukallu G, Mott BT, Beswick P, Klose RJ, Oppermann U, Jadhav A, Heightman TD, Maloney DJ, Schofield CJ, Simeonov A
PLoS ONE , (5), e15535, 2010.
Article Pubmed
BACKGROUND: Small molecule modulators of epigenetic processes are currently sought as basic probes for biochemical mechanisms, and as starting points for development of therapeutic agents. N(ε)-Methylation of lysine residues on histone tails is one of a number of post-translational modifications that together enable transcriptional regulation. Histone lysine demethylases antagonize the action of histone methyltransferases in a site- and methylation state-specific manner. N(ε)-Methyllysine demethylases that use 2-oxoglutarate as co-factor are associated with diverse human diseases, including cancer, inflammation and X-linked mental retardation; they are proposed as targets for the therapeutic modulation of transcription. There are few reports on the identification of templates that are amenable to development as potent inhibitors in vivo and large diverse collections have yet to be exploited for the discovery of demethylase inhibitors. PRINCIPAL FINDINGS: High-throughput screening of a ∼236,000-member collection of diverse molecules arrayed as dilution series was used to identify inhibitors of the JMJD2 (KDM4) family of 2-oxoglutarate-dependent histone demethylases. Initial screening hits were prioritized by a combination of cheminformatics, counterscreening using a coupled assay enzyme, and orthogonal confirmatory detection of inhibition by mass spectrometric assays. Follow-up studies were carried out on one of the series identified, 8-hydroxyquinolines, which were shown by crystallographic analyses to inhibit by binding to the active site Fe(II) and to modulate demethylation at the H3K9 locus in a cell-based assay. CONCLUSIONS: These studies demonstrate that diverse compound screening can yield novel inhibitors of 2OG dependent histone demethylases and provide starting points for the development of potent and selective agents to interrogate epigenetic regulation.
A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor.
Neumann S, Eliseeva E, McCoy JG, Napolitano G, Giuliani C, Monaco F, Huang W, Gershengorn MC
J. Clin. Endocrinol. Metab. , (96), 548-54, 2011.
Article Pubmed
CONTEXT: Graves' disease (GD) is caused by persistent, unregulated stimulation of thyrocytes by thyroid-stimulating antibodies (TSAbs) that activate the TSH receptor (TSHR). We previously reported the first small-molecule antagonist of human TSHR and showed that it inhibited receptor signaling stimulated by sera from four patients with GD. OBJECTIVE: Our objective was to develop a better TSHR antagonist and use it to determine whether inhibition of TSAb activation of TSHR is a general phenomenon. DESIGN: We aimed to chemically modify a previously reported small-molecule TSHR ligand to develop a better antagonist and determine whether it inhibits TSHR signaling by 30 GD sera. TSHR signaling was measured in two in vitro systems: model HEK-EM293 cells stably overexpressing human TSHRs and primary cultures of human thyrocytes. TSHR signaling was measured as cAMP production and by effects on thyroid peroxidase mRNA. RESULTS: We tested analogs of a previously reported small-molecule TSHR inverse agonist and selected the best NCGC00229600 for further study. In the model system, NCGC00229600 inhibited basal and TSH-stimulated cAMP production. NCGC00229600 inhibition of TSH signaling was competitive even though it did not compete for TSH binding; that is, NCGC00229600 is an allosteric inverse agonist. NCGC00229600 inhibited cAMP production by 39 ± 2.6% by all 30 GD sera tested. In primary cultures of human thyrocytes, NCGC00229600 inhibited TSHR-mediated basal and GD sera up-regulation of thyroperoxidase mRNA levels by 65 ± 2.0%. CONCLUSION: NCGC00229600, a small-molecule allosteric inverse agonist of TSHR, is a general antagonist of TSH receptor activation by TSAbs in GD patient sera.
Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor.
McCoy JG, Marugan J, Liu K, Zheng W, Southall N, Huang W, Heilig M, Austin C
ACS Chem Neurosci , (1), 559-574, 2010.
Article Pubmed
Antagonists of the Neuropeptide S Receptor have been postulated as promising therapeutics in the treatment of respiratory, sleep, anxiety, and addictive disorders. Here we present the SAR of a new series of orthosteric antagonists. Neuropeptide S Receptor signaling is coupled to both Gq and Gs proteins, and we observe that different analogues in this structural series can selectively antagonize these two pathways. Many G-protein coupled receptors transduce signals through multiple pathways. Selective antagonism of these pathways may lead the way to the development of more targeted pharmacological profiles and therapies.
CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP.
Ju W, Zhang M, Jiang J, Thomas C, Oh U, Bryant BR, Chen J, Sato N, Tagaya Y, Morris JC, Janik JE, Jacobson S, Waldmann TA
Blood , (117), 1938-46, 2011.
Article Pubmed
The retrovirus, human T-cell-lymphotrophic virus-1 (HTLV-I) is the etiologic agent of adult T-cell leukemia (ATL) and the neurological disorder HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-I-encoded protein tax constitutively activates interleukin-2 (IL-2), IL-9, and IL-15 autocrine/paracrine systems that in turn activate the Jak3 (Janus kinase 3)/STAT5 (signal transducers and activators of transcription 5) pathway, suggesting a therapeutic strategy that involves targeting Jak3. We evaluated the action of the Jak3 inhibitor CP-690,550 on cytokine dependent ex vivo proliferation that is characteristic of peripheral blood mononuclear cells (PBMCs) from select patients with smoldering or chronic subtypes of ATL, or from those with HAM/TSP whose PBMCs are associated with autocrine/paracrine pathways that involve the production of IL-2, IL-9, IL-15, and their receptors. CP-690,550 at 50 nM inhibited the 6-day ex vivo spontaneous proliferation of PBMCs from ATL and HAM/TSP patients by 67.1% and 86.4%, respectively. Furthermore, CP-690,550 inhibited STAT5 phosphorylation in isolated ATL T cells ex vivo. Finally, in an in vivo test of biological activity, CP-690,550 treatment of mice with a CD8 T-cell IL-15-transgenic leukemia that manifests an autocrine IL-15/IL-15Rα pathway prolonged the survival duration of these tumor-bearing mice. These studies support further evaluation of the Jak3 inhibitor CP-690,550 in the treatment of select patients with HTLV-I-associated ATL and HAM/TSP.
High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements.
Chen C, Kulakova L, Southall N, Marugan J, Galkin A, Austin C, Herzberg O, Zheng W
Antimicrob. Agents Chemother. , (55), 667-75, 2011.
Article Pubmed
The human pathogen Giardia lamblia is an anaerobic protozoan parasite that causes giardiasis, one of the most common diarrheal diseases worldwide. Although several drugs are available for the treatment of giardiasis, drug resistance has been reported and is likely to increase, and recurrent infections are common. The search for new drugs that can overcome the drug-resistant strains of Giardia is an unmet medical need. New drug screen methods can facilitate the drug discovery process and aid with the identification of new drug targets. Using a bioluminescent ATP content assay, we have developed a phenotypic drug screen method to identify compounds that act against the actively growing trophozoite stage of the parasite. This assay is homogeneous, robust, and suitable for high-throughput screening of large compound collections. A screen of 4,096 pharmacologically active small molecules and approved drugs revealed 43 compounds with selective anti-Giardia properties, including 32 previously reported and 11 novel anti-Giardia agents. The most potent novel compound was fumagillin, which showed 50% inhibitory concentrations of 10 nM against the WB isolate and 2 nM against the GS isolate.
High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.
Niesen FH, Schultz L, Jadhav A, Bhatia C, Guo K, Maloney DJ, Pilka ES, Wang M, Oppermann U, Heightman TD, Simeonov A
PLoS ONE , (5), e13719, 2010.
Article Pubmed
BACKGROUND: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH, EC 18.104.22.168) is the key enzyme for the inactivation of prostaglandins, regulating processes such as inflammation or proliferation. The anabolic pathways of prostaglandins, especially with respect to regulation of the cyclooxygenase (COX) enzymes have been studied in detail; however, little is known about downstream events including functional interaction of prostaglandin-processing and -metabolizing enzymes. High-affinity probes for 15-PGDH will, therefore, represent important tools for further studies. PRINCIPAL FINDINGS: To identify novel high-affinity inhibitors of 15-PGDH we performed a quantitative high-throughput screen (qHTS) by testing >160 thousand compounds in a concentration-response format and identified compounds that act as noncompetitive inhibitors as well as a competitive inhibitor, with nanomolar affinity. Both types of inhibitors caused strong thermal stabilization of the enzyme, with cofactor dependencies correlating with their mechanism of action. We solved the structure of human 15-PGDH and explored the binding modes of the inhibitors to the enzyme in silico. We found binding modes that are consistent with the observed mechanisms of action. CONCLUSIONS: Low cross-reactivity in screens of over 320 targets, including three other human dehydrogenases/reductases, suggest selectivity of the present inhibitors for 15-PGDH. The high potencies and different mechanisms of action of these chemotypes make them a useful set of complementary chemical probes for functional studies of prostaglandin-signaling pathways. ENHANCED VERSION: This article can also be viewed as an enhanced version in which the text of the article is integrated with interactive 3D representations and animated transitions. Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the web plugin are available in Text S2.


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gds international - making leadership happen
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DESCRIPTIONMore than ever, in a fast-changing and interconnected world, organizations feel the need for leadership. As a result, managers get a lot of advice on how to be more effective leaders. Articulate a clear vision, engage your employees, develop talent, have a global mindset, think strategically, create win-win solutions, leverage diversity, communicate effectively, hold people accountable, be an agile learner. On one level, all of this advice makes great sense. Who could argue with it? At another level, it can be overwhelming. First, the lists of leader characteristics and behaviors seem endless. Its as if weve taken every positive human quality and made it into a requirement for effective leaders. Second, some of the advice can seem contradictory at times. Managers are told to take charge and to empower others, to be politically savvy and authentic, to be flexible and steadfast.
- 1.A White PaperMaking Leadership HappenBy: Cynthia McCauleyThe ideas expressed in this paper represent the collective workof many colleagues at the Center for Creative Leadership.Issued May 2011
2. CONTENTS 3A Whole System Approach to Leadership 4When Leadership Is Happening: Multiple People, Multiple Processes 9The Managers Role in Making Leadership Happen 11 About the Author 3. A Whole System Approach to LeadershipMore than ever, in a fast-changing and interconnected world, organizations feel the need for leadership. As aresult, managers get a lot of advice on how to be more effective leaders. Articulate a clear vision, engage youremployees, develop talent, have a global mindset, think strategically, create win-win solutions, leverage diversity,communicate effectively, hold people accountable, be an agile learner. On one level, all of this advice makes greatsense. Who could argue with it? At another level, it can be overwhelming. First, the lists of leader characteristicsand behaviors seem endless. Its as if weve taken every positive human quality and made it into a requirement foreffective leaders. Second, some of the advice can seem contradictory at times. Managers are told to take chargeand to empower others, to be politically savvy and authentic, to be flexible and steadfast.At CCL, we think its time to step back and take a different approach. Instead of putting the entire weight of lead-ership on individual managers and their capabilities, we think its important to examine how the wholesystem is involved in making leadership happen. For example, the exchanges between employees andtheir managers, the interactions among peer managers or team members, the quality of relationships throughoutthe organization, the actions of teams and committees, and the use of existing organizational structures andprocesses all of these aspects of an organization can impact whether leadership happens or not. Dont get uswrong. We arent abandoning the importance of individual managers examining and further developing their tal-ents and capabilities. Rather, were suggesting that such an exercise is necessary but not sufficient for improvingleadership in groups, organizations, and society.What do we mean when we say making leadership happen? First, in our whole system perspective, leadershiphappens in the interactions and exchanges among people with shared work. Leadership can behappening within teams, workgroups, task forces, divisions, communities, and whole organizations. Leadership canbe happening across teams, levels, and functions. (Youll find me using the word collective as a generic term forall the different forms that groups of people might take.) Regardless of the collective, for leadership to happen,the interactions and exchanges among people have to yield: 3 4. Agreement on what the collective is trying to achieve together (Direction), Effective coordination and integration of the different aspects of the work so that it fits together in service of the shared direction (Alignment), and People who are making the success of the collective (not just their individual success) a personal priority (Commitment).These three outcomes direction, alignment, and commitment (DAC for short) make it possible for individualsto work together willingly and effectively to realize collective achievements. So when we say making lead-ership happen, we mean making direction, alignment, and commitment happen. In fact, we thinkthe only way to know if leadership has happened is to look for the presence of these three outcomes.There are many different ways that leadership happens. Sometimes a single individual plays a major role in mak-ing it happen. Sometimes it simply emerges in the conversations and interactions among people working togeth-er. Sometimes different people play different roles to bring it about. Both formal and informal processes can makeit happen. What brings about DAC in one situation may not bring it about in another situation. There are no easyformulas.Before looking at some examples of how leadership happens, it is important to note that realizing collectiveachievements requires more than individuals working together willingly and effectively. Think of R&D teams cre-ating a new product, sales groups reaching revenue targets, organizations producing goods and services, a schoolincreasing its graduation rates, a community creating a more sustainable environment. Although leadership isessential for such accomplishments, achieving these results is also dependent on other factors such as financialresources, people with the right technical knowledge and skills, appropriate technology, and effective businesspractices. Sometimes we can put too much emphasis on leadership, forgetting that it is only oneingredient in the recipe for organizational success. When Leadership Is Happening: Multiple People, Multiple ProcessesAs already noted, leadership happens in different ways. Consider the following scenario: The senior management team of a hospital (one that is part of a large healthcare organization) talked in meetings over several weeks about the hospitals recent results on a standard set of quality of care met- rics (hospital performance measures that are made available to the public by the U.S. government). Their performance was a bit above average enough to keep them in the good graces of headquarter executives but what should their goals be going forward? After much discussion, they unanimously agreed that they 4 5. should set their goals higher than the goals given to them by headquarters. Two factors seemed to figure into their decision. First, in recent years they had been working to re-establish their reputation in the local community. They felt that overachieving was a way to get the attention of people in the community. Second, they had a bit of a chip on their shoulder when it came to the healthcare organization. Being one of the organizations smaller hospitals, they sometimes felt overlooked. This was an opportunity to show what they could do. Raising a hospitals scores on quality metrics takes the concerted effort of the entire staff. So the manage- ment team took their vision out into the organization. They held formal meetings to share the goals and to explain why they thought it was important to set the bar high and why they thought the hospital was up to the challenge. In the meetings, they first gauged the level of enthusiasm for taking on these lofty goals and found that the hospital staff was enthusiastic. The staff clearly took pride in their work and wanted to be part of an organization known for its high-quality care of patients. During the meetings, staff members were also asked to generate strategies for reaching the goals. These ideas were brought back to senior team meetings and assigned to the appropriate individual or department to explore further. Special efforts were made to engage the medical staff a group essential to the hospitals success but not employed by the hospital. Believing that doctors are most influenced by other doctors, the hospital CEO first enlisted the help of a small group of physicians whom he knew would be eager to support the initiative, and this group became ambassadors to the medical community. The eventual result of all the meetings, conversations, suggestions, and explorations was a detailed two-year plan for increasing quality of patient care at the hospital. The plan involved every department and unit in the hospital. Two practices were put into place to keep the initiative moving in the right direction. First all managers were expected to schedule time each week to get out among staff and keep the initiative visible: they looked for evidence of plan execution, asked about successes and problems encountered, and reinforced the impor- tance of the initiative. The VP of Nursing was particularly vigilant with her quality rounds and served as a role model for others. Second, an oversight committee was established. A group of 25 managers and physicians met regularly to track progress, make adjustments, and vet new ideas. A strong sense of account- ability developed within the group as they saw how strongly each member believed in the importance of what they were trying to achieve as an organization. The result: Two years later, an independent organization listed the hospitals quality of patient care as tenth best in the nation. Employee satisfaction was in the 95th percentile and physician satisfaction was in the 94th percentile nationally.Clearly leadership is happening in this scenario. There was a shared direction. People were coordinating theirefforts in service of that direction. Commitment to the initiative was high. How was all this DAC created?Through many different interactions and exchanges. Some of the key ones are highlighted in the chart below.5 6. IMPROVING PATIENT CAREHow was direction created? By joining in a movement that was already afoot in the healthcare field a movement to enhance the quality of patient care in hospitals. By customizing organizational goals in ways that met local needs and desires. By having organizational goals crafted through discussion and joint agreement at the top of the organization and then tested for acceptance through meetings with staff throughout the organization. By having those who already shared in the direction influence others.How was alignment created? By involving many throughout the organization in crafting an implementation plan that specified department and unit responsibilities. By managers staying abreast of how implementation was going on the front lines and by employees keeping them abreast. Through a coordinating committee that monitored progress and made adjustments.How was commitment created? By connecting the improvement initiative to the existing motivations of individuals (e.g., to achieve beyond what others expected, to deliver high-quality patient care). By drawing attention


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O'Fallon car hire
Search hundreds of travel sites at once for car rental deals in O'Fallon
Same drop-off
Compare vs KAYAK |
O'Fallon, MO, United States
O'Fallon car hire information
|Pick-up location
|Hire locations
O'Fallon car hire reviews and directory
Rated no. 1
Best rated
9.0 Excellent (2 reviews)
Budget reviews
Car hire locations
Locations in O'Fallon
2721 Highway K
+1 636 379 9853
|07:00 - 18:00
|07:00 - 18:00
|07:00 - 18:00
|07:00 - 18:00
|07:00 - 18:00
|08:00 - 13:00
|10:00 - 13:00
Recent reviews
8.0 Excellent
28 May 2018
Pros: They signed me up for reward program.
10.0 Excellent
20 Jun 2019
Pros: Staff is always positive and happy, rented twice from them and could not have been happier
Cons: Nothing
Rated no. 2
9.0 Excellent (2 reviews)
Enterprise reviews
Car hire locations
Locations in O'Fallon
1491 Mexico Loop Rd E
+1 636 240 8886
|07:30 - 18:00
|07:30 - 18:00
|07:30 - 18:00
|07:30 - 18:00
|07:30 - 18:00
|09:00 - 13:00
|10:00 - 14:00
Recent reviews
10.0 Excellent
9 Sep 2019
Pros: Super friendly staff, quick service
Cons: Nothing they did a great job
8.0 Excellent
4 Dec 2019
Pros: I had to cancel my reservation.
Cons: I had to cancel my reservation
Rated no. 3
7.4 Good (2 reviews)
Hertz reviews
Car hire locations
Locations in O'Fallon
1120 Technology Drive Ste 111
+1 636 300 0902
|07:00 - 18:00
|07:00 - 18:00
|07:00 - 18:00
|07:00 - 18:00
|07:00 - 18:00
|09:00 - 12:00
Recent reviews
4.8 Okay
28 Feb 2017
Cons: When I arrived to pick up my rented standard group vehicle (VW Jetta), they had none on site or any standard vehicle for that matter. The agent insisted that an intermediate group vehicle (Toyota Corolla) was "similar" and therefore acceptable. I pointed out their own documentation on line clearly showed they were two different car groups. I had to pay an extra $84 to get a car that was big enough for our trip. I corresponded by email to the area manager that, since they did not have the car I rented on site and I was forced to upgrade, to do the right thing and refund my additional charge. He did not. I plan to push this issue up the management chain.
10.0 Excellent
2 Jul 2019
Cons: When we went to pick up the large SUV we had reserved, they didn't have it, but they made it right by giving us an even bigger vehicle for the same price. Their customer service was excellent and could not have been better.
Rated no. 4
7.2 Good (2 reviews)
Avis reviews
Car hire locations
Locations in O'Fallon
2721 Highway K
+1 636 978 5422
|07:00 - 18:00
|07:00 - 18:00
|07:00 - 18:00
|07:00 - 18:00
|07:00 - 18:00
|08:00 - 13:00
|10:00 - 13:00
Recent reviews
9.2 Excellent
17 Aug 2018
Pros: nice car. pick up and drop off fine.
Cons: my bill went from $188 to $435, but avis after several calls dropped it back down. my reservation was made at a location close to but not at the st louis airport. i picked up and dropped at the airport location and no one mention I was at the wrong location. kayak and avis both need to do a better job of making sure you know your reservation is at the airport or not.
5.2 Okay
9 Jul 2019
Cons: I reserved a car and was given wrong pick up location. When you are flying into an airport and need a car, obviously expect the pickup location to be at airport not 30 miles away with no way to get there. you go to rent the car from airport location it is now more than double what you reserved it
8 travellers who hired a car in O'Fallon gave the car agency they used an average rating of 8.2
Car hire locations in or near O'Fallon
When to book a car hire in O'Fallon
Car hire prices as pick-up date approaches
-1 day
-2 days
Top tips for hiring a car in O'Fallon
- Book your car hire in O'Fallon at least 1 day before your trip in order to get a below-average price
FAQs about hiring a car in O'Fallon
What is the best car hire agency in O'Fallon?
Based on ratings and reviews from real users on KAYAK, the best car hire companies in O'Fallon are Enterprise (9.0, 2 reviews), Budget (9.0, 2 reviews), and Hertz (7.4, 3838 reviews).
Which car hire agencies are at the airport: Lambert-St Louis airport (STL)?
Car hire companies onsite at Lambert-St Louis airport include Alamo and Budget.
Which car hire companies will pick you up at the airport: Lambert-St Louis airport (STL)?
Car hire companies that offer shuttle or pick-up services from Lambert-St Louis airport to off-airport locations include Alamo and Budget.
How can I find a car hire near me in O'Fallon?
Take a look at our extensive car hire location map to find the best car hire deals near you.


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There are a number of factors to consider when assessing the right pricing model for your freelancer management system. Learn how to select the right one for your organisation with this guide.
A hidden workforce exists in nearly every large organisation. In this guide, we'll explore some of the issues that create an organisation's hidden workforce and look at how to begin reclaiming control.
This guide looks at what the SOW is and how smarter technology can help improve the management of this critical resourcing model.
External link


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Your friends are fundraising. Don't miss out, opt in.
We find gaps in Bristol's provision for people experiencing homelessness and work together with our community to create innovative projects to fill them. Our mission is to create a caring city empowered to solve homelessness.
Caring in Bristol Registered charity number 1151645
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£5.00 + £1.25 Gift Aid
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David Shephard has raised $4,366.49 so far
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Facts of Ezequiel Lavezzi
|Full Name:
|Ezequiel Lavezzi
|34 years 11 months
|Birth Date:
|May 03, 1985
|Lucky Number:
|Lucky Stone:
|Lucky Color:
|Best Match for Marriage:
|Virgo, Cancer, Capricorn
|Birth Place:
|Villa Gobernador Galvez, Argentina
|Mother's Name:
|Doris Alonso
|Marital Status:
|In Relation
|Diego Lavezzi
|Professional Soccer Player
|Height / How tall? :
|5 feet 8 inches (1.75m)
|$ 26,984,755.20
|Net Worth:
|$94 million
|Hair Color:
|Eye Color:
|Facebook Profile/Page:
|Twitter Profile:
|Instagram Profile:
|Wikipedia Profile:
|IMDB Profile:
|Official Website:
|View more / View less Facts of Ezequiel Lavezzi
Read more about Ezequiel Lavezzi's Estimated Net Worth, Age, Bio, Career, Family. Also learn details information about Ezequiel Lavezzi's Bio, Parents, Education, Nationality, Ethnicity, Son, Relationship, and Images.
Ezequiel Ivan Lavezzi is popularly known as Ezequiel Lavezzi who is a professional football player. He usually plays as the secondary striker for the Argentinian national team and Chinese club, Hebei China Fortune as a winger. Similarly, he also played for clubs like Italian Serie A club, Napoli and the French professional football club, Paris Saint Germain FC.
Quick Biography
Ezequiel Lavezzi: Bio, Age, Nationality, Ethnicity, Parents
Ezequiel Lavezzi was born on 3 May 1985 in Villa Gobernador Galvez, Argentina. As of 2020, he is 34 years old. As per his nationality, he is Argentinian but his ethnicity is unknown. Similarly, his zodiac sign is Taurus.
Talking about his family, his mother's name is Doris Alonso but there is no information about his father. As per his siblings, he has a brother named Diego Lavezzi.
Read Footballer Josh Kennedy birth, age, family, childhood, career, wife, child, body measurements, net worth, and salary
Ezequiel Lavezzi: Education History
The information regarding his educational background is under review.
Height, Eye, Hair
Talking about his body measurements, he has a height of 5 feet and 8 inches and his weight is around 75kg. Similarly, he has a black color eye and his hair color is black. On his chest, he has a tattoo of Jesus.
Relationship, Married?
Talking about his relationship status, currently, he is in a relationship with the Argentian model, Yanina Screpante whom he has dated since 2011.
Moreover, He has a son named Tomas Lavezzi who was born with his former wife, however, he has not shared any information about his former wife. In addition, he was also known to date tennis star Juan Martin del Potro.
Also read Ansu Fati Bio, Age, Wiki, Relationship, Net Worth, Dating, Football, Height, Nationality, Ethnicity
Facebook, Twitter, Instagram
He has a huge fan following on social media. He has more than 5.1 million followers on Twitter and around 3.4 million on Instagram. Similarly, he holds over 6 million followers on his Facebook account.
Professional Life and Career
Talking about his career, he started playing soccer from an early age. From the age of 10 to 18, he played in the Rosario Central youth soccer system. He made his professional debut in the year 2003 for Estudiantes. In 2004, he was transferred to a fellow Argentinian football club, San Lorenzo.
Further, he was transferred to Italy and concluded an agreement with the Italian Series A Club, Napoli, in 2007 at an estimated transfer fee of about €6 million. Moreover, in his first match against Pisa in series A, Lavezzi made an immediate impact and played a major role in the 2011/12 handling of Napoles Coppa Italia.
In 2012, he signed a contract with the club, Paris Saint Germain after his successful time with the Italian club, Napoli. Currently, he is playing for the Chinese football club, Hebei China Fortune FC with whom he signed a two-year deal in February 2016.
International Career
He made his international debut at the 2008 Summer Olympics, where he won golds as an Argentinean player, against Chile. When Argentina was playing a friendly match against Albania on 20 June 2011, Lavezzi scored his first international goal for his team.
Furthermore, he also played for Argentina's team at the FIFA World Cup 2014 where Argentina lost to eventual winners, Germany.
He got into a lot of trouble when he pulled his eye back to indicate stereotypical Chinese face, the gesture brought a major uproar, which led to the accusation that he was racist, and later excused the Chinese people for his actions.
Net Worth/Salary
Talking about his income, his estimated net worth $94 million and his salary is 20.8 million GBP which is equivalent to $26,984,755.20 US dollars.
You may also like Aden Liban Bio, Age, Nationality, Net Worth, Height, Instagram, Family, Song, YouTube Videos


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Aaron Fruits
Paradise of Freshness
Refreshed Look for a Global Fruits Company
Aaron is an international fruit & vegetable supplier brand based in Dubai. Aaron wanted a refreshed brand identity to stand out in the global market.
To stand out in a crowded global market, we had to create a distinctive identity - where major players have already established companies with years of experience and large volume business.
We created an exciting identity and refined all communications - that helped the brand stand out in international exhibitions and business deals
Identity, Brand Guidelines, Brochure, Website & Marketing collaterals
Accelerating the Global Brand in Local Roads
Premium Experience for an Arabian Confectionery Store


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Mar 30, 2018
Material Behavior is a key subject for material studies and also very important for the mechanical engineering career. This course is very helpful and very easy to understand the hole concepts.
Jun 17, 2016
The course was excellent. A lot of in-depth material, beyond even what I remember from college. Coverage of polymer systems in addition to the usual metals was very nice, and the
By Roberta N L•
Feb 10, 2019
By 李一凡•
Aug 22, 2017
By Manoj S•
Aug 12, 2019
By Bhanu K•
Mar 27, 2019
By Amit k m•
Mar 11, 2019
By penperoo7•
Jun 12, 2017
By Rajneesh K G•
Mar 26, 2019
By 唐雪松•
Mar 06, 2017
By Marieke S•
Jul 31, 2017
A great and very informative course! Thank you! Some known mistakes (-> discussed in the forum) should be corrected though; especially those very annoying ones in the quizzes where correct answers are marked as incorrect and incorrect answers have to be selected to pass the quiz. Sometimes information to pass all quiz questions is missing in the slides of the lecture. However, most of the times, the answer can easily be found out by some additional source (literature, internet etc.).
By himanshu•
Nov 13, 2016
Gives brief understanding of almost every aspect Materials engineering. Effort is required from the side of student to understand the concept wholly. Many complicated topics are dealt with with relative ease and from basics.
By Tianyi L•
Jul 21, 2016
A very organized and well guided course. However, the contents are fairly difficult for a pre-university students.
By Robert•
Aug 29, 2016
Pretty good teacher. Easy words for not native-speakers. German subtles would be great.
By Joshua K•
Nov 18, 2016
Some quizzes ask questions that aren't discussed until subsequent lectures.
By DEEP B•
Aug 20, 2017
Good review of fundamentals and application based understanding
By sintu r•
Mar 17, 2017
A really nice course. I would have wanted more about polymers.
By Muhammad G T•
Jun 10, 2018
It was very great to get enrolled in this course.
By Shriya P P•
Jan 04, 2020
good knowledge giving course
By mudit•
Mar 11, 2019
good communication skill
By SAIGEETA P•
Jan 09, 2017
Very good course
By Surendra D•
Mar 17, 2019
By Kataria M B•
Jun 15, 2018
By raymond j•
Dec 08, 2016
By Anjali B•
Jul 04, 2019
After week 2 it gets very hard for students that do not study Engineering. But it is still interesting to learn about material behavior.
By nayab a k•
Dec 05, 2018
It is a good course that build up and boost your basic concepts about different classes of materials.
By Tan W L•
Mar 17, 2017
Unable to download certain materials and no spontaneous reply was made


text:
- This topic has 3 replies, 2 voices, and was last updated 1 week, 2 days ago by .
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Support Forums › Forums › Search & Filter Pro › Pagination don't label active page with Ajax
Tagged: pagination
I use a custom theme with Search & Filter Pro. Everything work well except pagination in Ajax mode. I use paginate_links() function. Event the page are changing, the active page are not updated. It's a bit confusing for user. Do you have s solution for that?
Thanks for the support.
Are you able to send me a live link/URL to your search page so I can take a look?
This annotated screenshot should explain the problem:
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text:
Is it possible to view the library as a folder tree copying the lay-out of the actual file storage tree?
View as folder tree
Hello @PGDO, the folder view is not currently available in Audirvana. If you wish to have it you should consider go in the user voice : https://community.audirvana.com/c/user-voice-audirvana/50
Hello @Damien3 and thanks for answering.Unfortunately this is a dealbreaker unless there is something like a contex menu for Audirvana with wich I could play/enqueue music folders from a explorer?


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There are many different recipes for eggnog including one that originated in South Carolina, see : South Carolina Eggnog for the recipe at the end of this article. For a unique treat for Christmas, why not try your hand at your own homemade version?
This particular recipe calls for cooking this custard beverage prior to serving. This makes it a safe beverage for all to consume and tastes far better than the eggnog you see in the grocery store. If you love eggnog, this recipe will allow you to make it anytime of year, instead of waiting once a year to buy it.
This recipe makes 4-6 servings
2 1/2 cups of whole milk
1 cup of heavy whipping cream
4 beaten eggs
1/3 cup of sugar
1/8 tsp. salt
1/8 tsp. nutmeg (for garnish)
1/4 tsp. nutmeg (for eggnog)
2 tbsp. vanilla extract
4 tbs of confectioners sugar
1/4 to 1/2 cup of rum (omit this if for children)
In a sauce pan, combine 1/3 cup of sugar, eggs and 1/8th tsp. of salt and beat the mixture with a fork or if you have one, a wired whisk. Slowly incorporate milk into the mixture and whisk until smooth. Continue stirring constantly and cook over medium heat, add nutmeg.
Mixture is finished when it has the ability to coat a metallic utensil.
Remove your mixture from the heat at this point and this is an ideal time to add the vanilla extract. Cool your mixture right in the sauce pan by placing the sauce pan in a large bowl of ice water. Making sure that none of the water of course gets into the mixture itself. Continue stirring during the process so that the mixture does not solidify. Once cooled, place pan in refrigerator.
Using the same ice water bowl, which should now be chilled, dump the ice water out and mix together confectioners sugar and heavy whipping cream. Beat with an electric mixer until you have solid stiff peaks that form. At this time if you are making an alcoholic version this would be the time to add the rum. If not, fold this mixture now into your refrigerated custard mixture. Serve in a beautiful punch bowl, and sprinkle additional nutmeg over it.
Tip: Want to make a special cool Eggnog for your children? Add in a packet of hot chocolate mix to the cooled eggnog and one teaspoon of mint extract for a chocolate mint eggnog. Garnish with a candy cane or crushed mint candy. They'll love it!
Other recipes by this author:
- Sweet Potato dessert cake
- Easy sweet potato casserole
- Upside down apple pie coffee cake
- How to make Red Velvet Cake with Orange cream cheese frosting
*South Carolina Eggnog


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sep 4 2014 uncovering a beautiful floors with this old house general contractor tom silva. (see below for tools.) click here to subscribe to 【Get Price】
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The four glass panel doors, matching the rich tones cappuccino finish of this versatile multimedia sideboard. As a sideboard in your dining room, the interior provide ample storage and visibility for your linens and silver. In your media room, fill it with books and games, plus your DVD/media equipment, as the cords can be tucked neatly through the cord management holes in the back! Overall Width - Side to Side: 71 Material: Solid Wood Material Details: 80% Mango wood and 20% iron Number of Interior Shelves: 4 Adjustable Shelves: No
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Newspaper article The Evening Standard (London, England)
Mr Green's Exit Leaves PM Isolated at the Top; Established 1827
Article excerpt
THE First Secretary of State has resigned because he forgot the first rule of political scandals: it's the cover-up that kills you. Damian Green made "inaccurate and misleading" statements to the civil servant, Sue Gray, originally asked to investigate whether his behaviour towards a journalist and family friend, Kate Maltby, had been inappropriate.
Ms Maltby has endured what felt like another form of harassment at the hands of some quarters of the media for daring to say publicly how uncomfortable she felt at Mr Green's approaches. If her claims had been dismissed out of hand, it would have discouraged other women from speaking out. Instead it was a vindication for Ms Maltby that the inquiry into Mr Green found her account "plausible". This probably would have forced his resignation even if No 10 had tried to keep him as they wanted. After all, Theresa May had all but promised (in Ruth Davidson's words) to "clean the stables" and she'd established the precedent when she fired her Defence Secretary for claims of inappropriate behaviour without an inquiry.
But it was the fact that Mr Green didn't tell the truth to the Cabinet Office about police claims that pornography had been found on his parliamentary computer nine years ago that actually forced a very reluctant Prime Minister to fire him. It's a clear breach of the ministerial code but many, including this paper, will feel queasy that it was this dubious operation by former police officers that brought him down instead of the new post-Weinstein climate that makes sexual harassment in the workplace unacceptable.
No Davis resignation Mr Green's dismissal should not stop Met Commissioner Cressida Dick concluding her investigation into what many think looks like an unsavoury conspiracy. We also note in passing that David Davis has not gone ahead with his plan which this paper reported to resign if the PM fired Mr Green because of anything connected with the police raid in 2008. As has been observed: in politics, greater love hath no man than that he lay down his friends for his life. …


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Filter/Regulator, Metal Bowl, 1/2"
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Arrow Pneumatics #B754GW Specifications
|Item: Filter-Regulator
|Max. Incoming Pressure - Air Treatment: 250 psi
|Gauge Port Size: 1/2" NPT
|Max. Temp.: 175 Degrees F
|Adjustment Knob: Non Rising
|Filter Rating - Air Treatment: 25 micron
|Bowl Size - Air Treatment: 6.0 oz.
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|Overall Width: 2.65"
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|Item - Filter-Regulators: Filter-Regulator
|For Removal Of: Particles, Water
|Country of Origin (subject to change): United States
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The leaves are elliptical, lance-shaped, dark green in colour, with wavy edges and evident veins.
It is a perennial plant that, however, in European climates, can be grown as an indoor plant, or in the garden as an annual plant, as it is not able to withstand the harsh winter temperatures.
The Nilotic Crossandra is native to East Africa and has elliptical, dark green, shiny leaves up to ten centimetres long. The brick red flowers, grouped in terminal spikes, bloom from spring to autumn.
It is a plant that usually reaches 60 centimeters of maximum height, lends itself very well to be grown indoors.
The Crossandra nilotica is a variety of plant which, in order to develop at its best, needs to be placed in full light, but it is good to avoid exposure in full sun which damages the leaves and blocks the flowering. It is not a plant of simple cultivation as it requires a particular environment with rather constant humidity and temperatures, around 21 °C, in order to have a good flowering in the period from March to October.
It is also good to check that the plant is not placed in areas with cold air currents, which could damage it, even irretrievably, in a short time.
- To the genus Cordyline australis or Cordilinea belong about twenty species of shrubs or small evergreen trees, spread in Asia, Australia and South America, as well as several cultivars. These plants are also used for the…
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Watering, for the best health of the plant, should be done once a week to keep the soil moist as the plant can not stand to stay dry, but it is good to be careful not to exaggerate with In the cold season is watered with lukewarm water to prevent sudden changes in temperature will damage the plant.
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From March to June, semi-woody cuttings six to eight centimetres long are taken and rooted in a mixture of peat and sand at a temperature of twenty degrees. When the cuttings are rooted, they get invaded.
The multiplication by seed takes place in March at a temperature of fifteen degrees, keeping the containers in a sheltered place. When the plants are large enough, they are transplanted into pots.
These plants, after having bloomed, are to be pruned, cutting the branches with the flowers of two thirds.
The choice of the ideal soil for the Nilotic Crossandra is essential to ensure its growth; the best compound is formed by soil rich in organic substances and draining material such as peat and sand, so that it does not allow the stagnation of water. It is good that it has a slightly acidic pH.
Nilotic grill: Pests and Diseases
Rust occurs with orange pustules on the underside of the leaves. To avoid rottenness and mould, the dried leaves and flowers must be removed and the humidity and water retention checked. This plant can also be affected by aphids, which can be removed with specific products or by washing the leaves with soap and water, to be rinsed carefully.


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Modal Description
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Antitrust Case Filings
Antitrust Case Filings
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View the list of NAICS and SIC industry codes used by the Division. To view all industry codes, visit Census.gov.
Displaying 11 - 20 of 44
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Chief Executive Officer of the Udupi Zilla Panchayat Preeti Gehlot said on Monday that houses would be given on priority to persons with HIV through the Rajiv Gandhi Housing Corporation.
She was chairing a coordination meeting on providing various benefits and facilities to persons with HIV at the Zilla Panchayat Hall here.
Mr. Gehlot said that the departments concerned should provide housing to persons with HIV in the district. In 2017-18, only four had been given houses under the scheme, though the target was to provide 33 houses. Though the objective was to provide housing, this could not be done because of lack of housing sites.
The issue of providing concessional bus passes to persons with HIV, the functioning of the ART Centres in Udupi and Kundapur, too were discussed at the meeting.
Kaveri, member-secretary of District Legal Services Authority, Chidananda Sanju, District AIDS Control Officer, Seshappa, District Women and Child Welfare Officer, and other departmental heads were present.


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citizenM London Shoreditch, London
- Free WiFi in lobby
- Collect nights
More great choices
What's around citizenM London Shoreditch, London
- In London City Centre
- Tower of London - 29 min walk
- St. Paul's Cathedral - 29 min walk
- Brick Lane - 4 min walk
- Old Spitalfields Market - 7 min walk
- Covent Garden Market - 2.4 mi / 3.9 km
- Buckingham Palace - 3.7 mi / 6 km
- Camden Lock Market - 4.2 mi / 6.7 km
Getting around
- London (LCY-London City) - 15 min drive
- London (LHR-Heathrow) - 62 min drive
- London (LGW-Gatwick) - 85 min drive
- Shoreditch High Street Overground Station - 1 min walk
- London Shoreditch High Street Station - 2 min walk
- London Old Street Station - 10 min walk
- Old Street Underground Station - 10 min walk
- Liverpool Street Underground Station - 11 min walk
- Aldgate East Station - 13 min walk
At a glance
Key facts
Hotel size
- This hotel has 216 rooms
- This hotel is arranged over 8 floors
- Check-in time 2:00 PM-3:00 AM
- Check-out time is 11 AM
- Express check-in/out
Required at check-in
- Debit card required for incidental charges
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- No cribs (infant beds)
- Pets not allowed
- Free WiFi and wired Internet access in public areas
- WiFi in rooms *
WiFi rated super fast
- Great for browsing, email, gaming, streaming, and video chat
- No parking
Payment types at the property
Other information
- Smoke-free property
In the hotel
- Buffet breakfast daily (surcharge)
- Restaurant
- Bar/lounge
- Coffee shop/café
- Snack bar/deli
- Coffee/tea in a common area
- 24-hour front desk
- Luggage storage
- Multilingual staff
- Number of buildings/towers - 1
- Year Built - 2016
- Elevator
- Accessible bathroom
- In-room accessibility
- English
In the room
- In-room climate control (air conditioning)
- Hypo-allergenic bedding available
- Blackout drapes/curtains
- Soundproofed rooms
- Private bathroom
- Rainfall showerhead
- Shower only
- Designer toiletries
- Hair dryer
- Flat-screen TV
- Digital TV channels
- IPad
- WiFi (surcharge)
- Phone
- Free bottled water
- Daily housekeeping
Also popular with travelers from the USA
Special features
DiningCanteenM - This buffet restaurant serves breakfast, lunch, and dinner. Guests can enjoy drinks at the bar. Open 24 hours.
citizenM London Shoreditch, London's small print
Also known as
- citizenM London Shoreditch Hotel
- citizenM Shoreditch Hotel
- citizenM Shoreditch
PoliciesTax ID - 236564886
Noise-free guestrooms cannot be guaranteed.Parties and events are allowed on site.
Special cancellation policies or charges may apply for group reservations (more than 8 rooms for the same property / stay dates).
Optional extras
Late check-out can be arranged for an extra charge of GBP 29 (subject to availability)
Buffet breakfast is offered for an extra charge of GBP 8.95 per person (approximately)
WiFi is available in guestrooms for GBP 0 per stay (rates may vary)
We have included all charges provided to us by this property. However, charges can vary, for example, based on length of stay or the unit you book.
Recent reviews
Superb 9.2 From 902 reviews
Great location and easy access to the tube system. Rooms are small though. Excellent staff and good spread for breakfast.
I continue to return to Citizen M hotels because of their consistency. Friendly staff, cool vibes, fun decor, and comfort. I am a happy Citizen again!
Hôtel très confortable et bien agencé situé à quelques pas de Shoreditch High street. Vues intéressantes sur le chemin de fer et chambres très bien insonorisées. Restaurants à proximité. Excellent petit déjeuner anglais. Literie de qualité et douche avec mood lights.
We were on a quick trip to London, and citizenM has been our go-to the last few times. It's easy check-in, comfortable and it's within walking distance to everything. We had a great time in shoreditch but the comfort of the hotel made it a much more pleasant experience.
King bed was very comfortable! They replaced the free water every day which was key, always need to stay hydrated!
Is the description of this hotel not correct? Tell us


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dinsdag 8 december 2015
Hiska 213
Photo taken on October 13th, 2015
Location: Vrijhof, Universiteit Twente, Enschede, The Netherlands
Glasses Hiska (left): Zenni 665918 [L=R: +1.00]
Glasses Nel (right): Zenni 184717 [L: -11.00; c-1.25 v / R: -11.50; c-1.25 v]
October 13th was the day of the festivities marking my retirement from the university after 35 years. Aside from the reception and dinner, a couple of cultural events were added to the program. I did a music concert in the Amphitheater ("Culture Cracker") featuring guest uilleann piper Carel Lanters who played "The Coolin". I sang a Suzanne Vega classic called "The queen and the soldier" and a famous Irish song "An bonnán bui", learned from one of my favorite singers: Al O'Donnell. I made his acquaintance back in 1980 when he performed at a festival in Amsterdam and he was a guest in my house. Sadly, Al passed away just a month before the "Culture Cracker" concert, aged 71. Three video clips of the concert can be seen on vimeo Rob van Dijk.
But let's talk glasses.... The other cultural event was the opening of a new exhibition with "Ladies behind Crystal Veil". No catwalk this time - that would have been too much. The exhibition lasted four weeks, featuring forty models who posed for me between 2011 and 2015.
Long time followers of this weblog may remember Hiska. She did a fine photo shoot for me and she was one of the ten models who performed at the catwalk during the opening of my first exhibition, in 2010. Hiska had perfect eyesight and we agreed that if ever she would need glasses at a later stage, she would get a free pair as a fee for her photo shoot. A few months before my retirement, Hiska got in touch and she told me that it was time for her first pair of readers. We spent a pleasant lunch break and Hiska checked her looks in a dozen Zenni glasses brought along for the occasion. Hiska always liked the cat eye style so it came as no surprise that she chose this fine pair of cat eye glasses. She attended the concert and the reception, wearing the cat eye glasses on the top of her head. My partner Nel appeared in cat eye glasses by Zenni as well so we withdrew ourselves from the festivities for a moment and I took this double portrait of my loyal models.
Hiska's glasses (fitted with -8.00 lenses) were featured in four previous photo shoots, with Farishta, Maria, Jennifer and Mirjam. Nel's glasses (also fitted with -8.00 lenses) were only featured in my latest photo shoot with Farishta. The lenses in Nel's own pair shown here were made by a company called ciliaryblue, in England.
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