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Preparing for Data ScienceData Science is a very hot area of employment right now. Being a Data Scientist basically means you are a programmer and a statistician/mathematician, and you can apply the knowledge of both worlds to tasks involving large amounts of data.
In order to start on a career path towards Data Science, you need all of the courses in the first two years of university calculus.
Yeah, you need all of them! Calculus I, Calculus II, Multivariable Calculus, Differential Equations, Linear Algebra, and Probability Theory (Calculus-Based Statistics). There are no short-cuts available if you really want to be a data scientist. You need to be both a serious mathematician and a master programmer.
There are many websites around that suggest you can get all of this mathematics knowledge just from the free MOOC courses available around the internet. This recommendation seems unrealistic - there are also lots of mathematics books available at the library and at used book stores, but trying to make your way through those math books by yourself .... that is a tall order.
Plus, if you do take the MOOC route and then you wish to actually complete a Data Science certificate or academic degree, proving that you have the requisite mathematics knowledge is ... not as convincing as having these academic courses completed and showing on a university transcript!
Here is a video on Data Science and our Distance Calculus courses course:
Preparing for Data Science with Distance Calculus
MOOCs, Academic Credits, and Distance Calculus
Distance Calculus - Student Reviews
Date Posted: Jan 13, 2020
Review by: Janice Flores
Student Email: email@example.com
Courses Completed: Calculus II
Review: I highly recommend this course! Dr. Curtis is the best teacher and is ALWAYS willing to work with you to make sure you understand the subject. It was definitely a positive experience and the credits were transferred to my University with no problems! I definitely do not regret it and I had doubts in the beginning but if I had to, I would do it all over again!
Transferred Credits to: University of Central Florida
Date Posted: Jan 12, 2020
Review by: Anonymous
Courses Completed: Calculus I
Review: This course is amazing! I took it as a requirement for admission to an MBA program, and couldn't have been happier with the quality and rigor of the course. I previously took calculus two times (at a public high school and then a large public university commonly cited as a "public ivy"), this course was by far the best and *finally* made the concepts click. Previously I had no idea what was going on because terrible PhD students were teaching the course and saying stuff like "a derivative is the slope of a tangent line" - ??? but what does that mean ???, but the instructors in the Shorter University course explain everything in ways where it FINALLY made sense (e.g., "imagine a roller coaster hitting the top of a hill, there's a moment where it shifts momentum and you're not accelerating or decelerating, that's what a 0 rate of change is - that's when the derivative would be zero"). They explain everything in multiple ways and relate it to other concepts. It all made perfect sense when I finally had a good instructor. Really recommend this class
Transferred Credits to: The Wharton School, UPenn
Date Posted: Apr 5, 2020
Review by: Catherine M.
Courses Completed: Calculus I
Review: Calculus I from Distance Calculus was wonderful! I took AB Calculus in high school, but I didn't take the AP Calc exam. Instead I took Calculus I with Distance Calculus, and it was so much better! It was a little review of topics, but not really. I really understood calculus when I finished!
Transferred Credits to: University of Chicago


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Lanchester Avenue, Billingham £210,000
- 4/5 bedrooms
- Detached family home
- Extended and greatly improved
- Open plan living dining kitchen
- Block paved driveway
- Perfect for families looking for more space
- Bi-fold doors to garden
WOW TAKE A LOOK INSIDE THIS TRULY UNIQUE HOME! Greatly improved and extended by the current owners to provide this impressive and deceptively spacious living space which has been finished to the highest of standards. Internally comprising: entrance hall, cloakroom w/c, lounge and open plan dining kitchen opening into garden room with bi-fold doors out to the garden. To the first floor are 3 double bedrooms, master with fitted wardrobes and the 4th bedroom has access into an additional room (currently used as a bedroom) could potentially be a dressing room / play room, perfect for families looking for more space! To the front of the property is a smart block paved driveway providing off street parking for multiple cars and a private enclosed rear garden. Early viewing recommended to avoid disappointment.
Billingham TS23 2TD
Billingham TS23 2TD
Please complete the form below to request a viewing for this property. We will review your request and respond to you as soon as possible. Please add any additional notes or comments that we will need to know about your request.
Billingham TS23 2TD

subset: commoncrawl


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Welcome back to the Friday edition of NBA Top Plays! We have seven games on tap tonight and already have some big injury question marks in Denver and LA.
As always, make sure to check out RotoGrinders DFS Alerts App to stay up with injury news, and tune into the RotoGrinders Court Report at 6:00 EST through lock to get updated thoughts on the night ahead as news comes in.
Point Guard – Goran Dragic ($7,500 on both FanDuel and DraftKings)
Tyler Johnson remains out of action and the Heat have replaced him in the starting lineup with Derrick Jones, leading to even more offensive responsibility for The Dragon. Dragic leads the team with a 31.6% usage rate with all inactive/non-rotation members off the floor, good for a 1.17 FPPM mark which could take a step up in a prime draw with Brooklyn's back-court. In case you're curious, Dragic gets a +3.4% bump in usage in that split and a +0.17 FPPM differential, which is very notable given his mid-range price tag across the industry. There is legitimate 40-45 FP upside here at a big discount to other elite options at the position. If you're able to pay up at the PG spot, John Wall is an elite tournament play and one of the few studs at guard I'm making a point to pay up for in GPPs.
Shooting Guard – Will Barton ($7,700 on FanDuel, $6,500 on DraftKings)
We'll need to wait for confirmation that Jamal Murray is going to sit before deploying Barton heavily in all formats, but I actually think he's a viable target regardless. The $7.7K tag on FanDuel will keep him out of play for me if Murray is healthy, but assuming the Kentucky product needs another game to rest before returning from a concussion, Barton would figure to run the point again in a dream matchup with a fast-paced Suns team that ranks towards the bottom of the league in defensive efficiency. An up-and-down game sets up perfectly for Barton. He recorded a 27.3 AST% on Wednesday as the lead guard and while Harris (he racked up four assists) and Jokic are going to have the ball in their hands plenty, it's not like Barton can't add value through raw points. I like the Denver side a ton tonight and am hoping we can target them a little short-handed if Murray sits again. If you're looking for value (or a pivot in the event that Murray plays), there is value on the Lakers given the injuries to Lonzo Ball and Kentavious Caldwell-Pope. Josh Hart should play upwards of 30-32 minutes and Jordan Clarkson is also a candidate to see increased run.
Small Forward – T.J. Warren ($6,700 on FanDuel, $6,400 on DraftKings)
Given that I'm going to be heavily exposed to the Denver side, I'm going to want at least some Suns exposure with the hopes that they can stay within striking distance late. Warren is fully expected to return tonight and re-enter the starting lineup, and it does not appear as of this writing that he's going to be restricted at all in terms of minutes. Warren has missed the previous two games and missed another one on the 5th against the Spurs, but he's otherwise been playing normal (and big) minutes lately. With Marquese Chriss out and Tyson Chandler consistently starting at center, the Suns have next to no offensive punch in the starting lineup outside of Booker, so things are going to have to continue to run through he and Warren. Dragan Bender has been very up and down offensively of late, but the downs have been more frequent of late.
EDITOR'S NOTE: Need more value in your NBA Friday lineups? Spencer Limbach ranks the best bargains of the night in the FanDuel NBA Bargains column.
Power Forward – Domantas Sabonis ($6,000 on FanDuel, $6,400 on DraftKings)
The production hasn't been great since Sabonis entered the starting lineup for the injured Myles Turner, but a lot of that isn't his fault. He had a tough draw with Jusuf Nurkic – who owns one of the best DRPM grades among centers – last night and was forced to face off with a slow-paced Jazz team the night before. In the game prior to that, he was held to 24 minutes in a blowout, a game in which none of the Pacers starters played more than 29 minutes. Three slow performances and a stagnant price tag may lead to decreased GPP ownership tonight, but I'm fully on board against the Lakers front-court. I'd expect this one to stay tight throughout and if Sabonis is able to step into 33-34 minutes tonight, he absolutely has 40 FP upside at a $6K price tag. He's a lock-and-load play on FanDuel and can be utilized at PF or C on DraftKings.
Center – Nikola Jokic ($10,000 on FanDuel, $9,500 on DraftKings)
I'm going to have a ton of exposure to Jokic regardless of Jamal Murray's status, but Jokic would benefit slightly if he sat. The Suns actually defend centers fairly well considering how they perform against other spots (best matchup on the board for PGs, SGs, PFs), but Jokic's ability to contribute in all stat categories makes him a unique upside play at the center spot. There isn't a whole lot of high-end value on the board tonight and I prefer Jokic to Drummond straight up, so most of my center exposure is headed in that direction. I don't mind Willie Cauley-Stein as a GPP pivot (or Drummond for that matter) and will also have exposure to LaMarcus Aldridge at C on DraftKings.


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Write and publish an eBook. You don't need a traditional publisher and financial backing to publish your own book anymore. In fact, Amazon.com makes it possible for you to publish your own eBook and sell it independently – with no financial investment on your part. And with Kindle eBook publishing, your book will appear on Kindle stores worldwide within 24-48 hours. Just be prepared to market it yourself on social media, your blog, or elsewhere if you expect to generate sales.
Now next, you'll want to pick a WordPress theme from somewhere like Elementor, ThemeForest, Elegant Themes, Qode Interactive or OptimizePress that you can use today. This is the barebones design of your site, which you can then customize with your own branding, copy, and images. That being said, you don't want to cheap out. It costs less than $100 to buy a theme that will make your website look professional (and you can upgrade to a completely custom design once you get the business going). You'll also need strong marketing tools to grow your website, like HubSpot's All-in-One Marketing plugin.
Rent out a parking spot. If you live in a busy or congested area and have parking to spare, you might be able to rent out your parking space for some quick cash when you're not using it. Simply advertise your open parking space online including details on the location, whether it's covered or uncovered, and your desired hourly, weekly, or monthly fee. If you want, you can even use a site like Just Park or download the Spot App to reach more potential customers.
Hi 🙂 well I want to start a job. I need a job where there's no EXP necessary because i don't have EXP in anything never had a job. education well sadly I didn't finish H.S… I'm looking something easy to do, free fee to start, pays per hour and will get my paycheck daily or weekly, I could work in a computer or smartphone, I don't have typing exp but I can learn….
28. Subscription – If you think of something valuable (newsletter, online magazine, etc.) that you can consistently offer on a certain basis (weekly, monthly, etc.), you may want to offer a subscription service. This could be a fee charged each time your product is sent out or on a monthly basis. Either way, this has to be something that your customers can only get by subscribing to your website.
29. Videos – This could be an entire section on it's own. Many people have made money by creating YouTube videos. Evan of EvanTube is a kid and he has made millions by creating reviews of products that other kids his age would use. It's not easy to get views into the millions, but once you do, you'll start seeing some cash come in. Many bloggers have completely turned to videos to get their point across by starting a video blog.
Upwork: This website offers a great marketplace for selling just about any professional service. You don't need a merchant account, a website of your own or anything else for that matter. All you need to do is be able to provide a high-quality service at a reasonable price. But be informed, you will have to compete with many others that are constantly bidding on open jobs.
One should think about their skills, hobbies and basic daily habits as well. Do you like to cook? Be a personal cook or dinner parties. Baking? Make wedding cakes or cupcakes for weddings/special events. Do you enjoy cleaning? Trying going to banks/repo companies and ask if they are in need of a repo cleaner or market yourself as a all-around cleaner. Know how to mow a lawn? Get paid to do it in your neighborhood. Sell products from large companies – Jewelry in a candle, Sentsy, Health and home products – etc.
If you have experience with marketing, SEO, or a knack for getting people excited about the products and services you use on a regular basis, think about refining your skills and putting them to work making money online as a small business marketing consultant in your region—especially if you can become a local SEO expert and can help local clients rank higher in their search results.
Hello Ryan your business startup advice is helpful I'm at the moment trying to start my own blog, YouTube channel, podcast group, cooking videos may even do the English tutor to foreign countries and in the future graphics design T-shirts and mech with my own website . My only problems are a few things 1. I'm using a iPhone for Internet use 2. I'm not that popular yet and am trying to get a big audience 3. I'm not great with code/rusty . For my YouTube channel and blog I was going to do mental health, the criminal mind, self defence and survival tricks, and physical health, cooking, also sell digital art I am just not sure how to build a big audience. Should I make my content more flashy or seem extreme ?
Owning and maintaining an online business gives entrepreneurs the freedom to make money remotely from anywhere in the world. The idea is enticing, and more possible than ever, but many entrepreneurs struggle with how to get started. The most important step in starting a profitable online business is finding a business idea that matches your skills and strengths.
I really don't want to chat, receive or make calls (I have a kid and baby I don't have no silent place to work and also because I'm not a calm person I get mad easily fast), I don't want to go out at my home because of doing a "job", don't want to do survey, I don't want to write or share my thoughts or anything like that, I don't want sell anything either.
There's an audience for everything, even if it's as specific as dollhouse furniture or organic dog food. With a niche e-commerce store, you can reach customers who seek your specific products. Building a business in a niche market can help you differentiate yourself from other brands and build your credibility and expertise. Look to social media or your own consumer needs to come up with a product to sell online.
The ego is the driver making the decisions. It decides between the devil (the id) and the angel (the super-ego) on either shoulder (yes, all those cartoons you've ever seen are partly true). We have voices in our mind, and it's up to the ego to decide which one to fulfill. Its goal is to satisfy the id in some way while also attending to the super-ego.
23. Affiliates – There are many affiliate networks, such as FlexOffers and CJ Affiliate that allow you to promote other people's products and services. You simply put a link or a banner on your page and then you get a percentage if someone clicks through and buys the product/service. You'll want to select products that are specifically within your blog's category.This is an effective way to earn money once you have the traffic coming to your blog.
Starting a podcast, like making a YouTube channel or blog, comes down to telling interesting stories and building an engaged audience. I'm probably sounding like a broken record by now, but you need a niche that you're interested in and there's already a demand for. Come up with a list of topics you'd like to talk about and then search iTunes charts, Google Trends and other podcast research sites to see what's currently out there and popular.
If you are a creative, digital professional who thrives on forming the layout, visual theme, font set and color palette of a website, freelance web design may be a good path for you. If you have little to no experience in this field, you can learn the basics of web design and master the tools you'll need for success, like Adobe XD, Chrome DevTools and text editor software.
Ebates: This app offers a simple way to make money online by buying whatever you're already buying and then getting a cash-back reward. With eBates, there is no scanning receipts. Simply click a link in the app and buy it from the store. You'll automatically be credited with your cash rewards upon purchase along with receiving an email confirmation.
There are loads of resources for making money online as an affiliate. You could source products from ClickBank, Commission Junction, Rakuten Marketing, Share-a-Sale, Impact Radius and many others. Plus, many of the larger companies have their own affiliate programs as well. Do your due diligence and find the right company with a relevant product or service to your audience that you can sell as an affiliate.
I have started with affiliate marketing and focusing on becoming an authority website. All I realized in this process is the difficulty in becoming an authority website. It is not so easy but never impossible. So, I am putting hard work with smart work and trying as much as possible to boost the authority of my website. Hope, affiliate income starts rolling out soon.
One of the easiest ways to make a few bucks online is affiliate marketing. An affiliate is essentially someone who receives a commission for selling products for other companies, whether it's on their own site or through another channel like eBay. The best part is that you don't have to develop any products yourself, just sell other people's products.
When you lack the luxury of time, making money on or offline can seem like an impossible task. How are you supposed to do that when you're working at a life-sucking nine-to-five job? While the stability of full-time employment might allow most to sleep well at night, it doesn't empower your creative juices to search for new income-producing strategies.


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Sublime Villa & Caves Red Beach
An undeclared 0 star property with an unspecified number of rooms spread over an undefined number of stories. The property offers various recreational opportunities. For reliable service and professional staff, Sublime Villa caters to your needs. Service-minded staff will welcome and guide you at Sublime Villa. The property offers a wide range of amenities and perks to ensure you have a great time. To give an idea of cost, staying here will set you back per day about US$340. Guest rooms are designed


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Kakkoii!(かっこいい): The "Cool"est Japanese Word (Common Phrases)
Ever wonder what the "kakkoii" craze is all about in Japan? Today, we're going to take a look at this popular Japanese slang word and show you how to use…Continue reading
Ever wonder what the "kakkoii" craze is all about in Japan? Today, we're going to take a look at this popular Japanese slang word and show you how to use…Continue reading
Living it Up!: Top 15 Japanese Phrases for Looking for an Apartment : Not all Japanese schools and companies have living arrangements set up for their international students and employees….Continue reading
Use and Meaning of Toriaezu(とりあえず),Ittan,Tonikaku : Japanese has a lot of really useful words. There are a lot of words that mean the same thing as entire phrases in English….Continue reading
TAXI!: Phrases for Hailing a Cab in Japanese :Japan is known throughout the world for its punctual and reliable public transportation. However, there are times when you're too busy to…Continue reading
I'm Sick!: Top 10 Japanese Phrases to Use at the Hospital :When traveling or living in a foreign country, there is always the possibility of needing to go to the…Continue reading
You're Welcome: How to Use Douitashimashite in Japanese 😀oing something nice for others is one of the many joys we get out of life. When we do something nice for…Continue reading
The culture of kawaii is taking the world by storm. What is it? What does it mean? What is kawaii and what isn't kawaii? Today, we'll learn the various aspects…Continue reading
Today, we have 7 useful Japanese business phrases for talking on the phone to aid in your study! Japanese Romaji Meaning もしもし Moshi-Moshi Hello! ~の~と申します ~ no ~ to moushimasu…Continue reading
Japan is known for its polite phrases to use when calling businesses, organizations, and people whom you don't know personally. When we're talking to friends, however, we want to laugh,…Continue reading


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Noneillah Collection In New York Fashion Show 2-2015 The #Noneillah Brand is by celebrity Sean C… Noneillah Jul 29, 2016 71 views
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text: On 12/13/05, Alper Kamil Demir <demir at kou.edu.tr> wrote: > >From the basic ideal the rate of a TCP flow is indpendent from the RTT. > >Pracitically, it may oscillate because traffic might be bursty and > >irregular. > Could you please check RFC3448 (TCP Friendly Rate Control (TFRC): > Protocol Specification. It does depend on RTT. > You might like to look at http://wand.net.nz/~perry/max_download.php where a colleague of mine has made a TCP rate calculator. Also useful for DCCP CCID3 etc as uses TFRC calculation here also. -- Ian McDonald http://wand.net.nz/~iam4 WAND Network Research Group University of Waikato New Zealand


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D-Shell Earpiece with PTT/Mic
A headset with a D-shaped earpiece and a microphone combined in a single package with a PTT button. The product is intended for use in Motorola CP-Commersial radio stations, DP1400. The PMLN6535A transmitter is activated by a button on the cable or a PTT button on the radio itself.


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To view press releases of a specific category, select the appropriate category link
CouponMeUp.com has been saving consumers from paying full price with savings and discounts for thousands of online stores since 2007, this week the number of stores featured on CouponMeUp has passed 35,000 making it easier than ever to snare yourself a bargain for Christmas!
Innovative Vibrators Available through Singapore-based Website Become a Hit
Tau is just a piece of designer lighting equipment from FLOS for use on ceiling and wall. It is different than the contemporary concept of incandescent light as it has style in shape and color and ensured use of innovative technology.
This interesting website features lifestyle products for individuals, couples and families who enjoy investing in stylish audio visual furniture and accessories.
Top Google rated online luxury magazine VERYBEST.COM are proud to announce the list of award winners in the very best luxury services tier. The magazine announced the Product winners last month.
Just in time for the "Holiday Travel Season" ZEMgear has added a new line of light weight travel shoes designed to speed you through the TSA inspections and keep your feet comfortable on your holiday travels.
DELICARDO Foodcard is a proud recipient of the aha!award 2010 from the Swiss Allergy, Skin and Asthma Centre.
What makes you sick and tired around the holidays? Well, now is your chance to vent frustrations. Dazzling Concepts is holding a "Sick and Tired Holiday Contest" on Facebook that could put a smile on some faces and some money in your pocket!
Gloucestershire based Office Star do not only supply office stationery and low priced office products, they are now able to supply a wide range of PPE to businesses and factories across the country.
Sunset editors present insider travel tips on hotels in Las Vegas, must-see shows, and top spots to indulge in—and take respite from—Sin City excess in the free Sunset Travel Guide, Things to Do in Las Vegas: Restaurants, Resorts, Recreation, etc. 2011


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Contact the company directly. If you use a product or service and want to recommend it but you can't find evidence of an affiliate program, consider approaching them and asking if they are willing to set one up (maybe with your help). Highlight your audience and the value of your recommendation. Explain that an affiliate program is simply rewarding happy customers (you!) for promoting, and they don't have to pay until a sale is made.
how to start affiliate marketing business for free
Buy and sell domain names. If you're good at finding popular yet undiscovered domain names, you can make some cash on the side by buying and reselling websites. Think of it as digital real estate speculation. Domains are available on GoDaddy.com for as little as $2.99 per year, but are sometimes resold at far higher prices: According to Business Insider, the site MM.com sold for $1.2 million dollars in 2014. Once you find the perfect domain name to resell, you can market it on Flippa.com for a flat fee.
More than half a billion products are sold on Amazon every month, making it an incredible opportunity to make money online. But, like everything else that involves making money online, you have to do quite a bit of work to earn it. One option on Amazon is to find products that are already made and buy and sell them at a discount. For example, you could research generic products such as clocks, keychains and mugs to attach to your brand. For an incredible deep dive on how to make extra money with this strategy, check out how digital marketer Neil Patel recently did this as a public experiment right here on his blog.
Individual sellers and companies offering products or services have to deal with their consumers and ensure they are satisfied with what they have purchased. Thanks to the affiliate marketing structure, you'll never have to be concerned with customer support or customer satisfaction. The entire job of the affiliate marketer is to link the seller with the consumer. The seller deals with any consumer complaints after you receive your commission from the sale.
One of the great things about the internet is that you can go into business for yourself from the comfort of your home. All you need is an internet connection, and you can make money online. Diving into the online world will free you from the daily 9 to 5 grind of a desk job and afford you more time to travel, indulge in hobbies, and spend time with the family.
Understand how a niche website works. A niche website focuses on very targeted, specific information. The content must be specific, useful and interesting to your target audience. Successful niche websites get anywhere from 1,000 to 10,000 visitors per month.[5] You build content on a particular keyword, and you make passive income with Google Adsense or through affiliate links.[6]
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If you have witnessed something interesting that is worth the news, you could try selling it to the newspapers. Maybe you´ve been a witness of a burglary or a fight? And even have a video or photo? Then you can contact you local news and tell them about it. Some of the newspapers actually pay good money for interesting stories so keep your eyes open on the streets and have your camera ready!
I couldn't agree more the relationship with your audience, and the trust that you build with them, is the single most important asset you could ever have. Trust is the basis of all good marketing, If viewers do not trust you and see you as the expert, that they need to turn to, then the chances that you will succeed with Affiliate marketing in the long-term, are very slim. Such a great content and a perfect key strategy for every business industry to prosper. These were awesome, looking forward for more valuable content of yours!
6. IZEA – IZEA works in addition to a blog or on its own. You get paid to blog, tweet, take photos and take videos. The pay is mostly based on your following, so if you want to make money with your tweets, you'll need to grow you Twitter following. Likewise, if you want to make money with blogs, you'll need substantial blog traffic (more on blogging below).
Since the emergence of affiliate marketing, there has been little control over affiliate activity. Unscrupulous affiliates have used spam, false advertising, forced clicks (to get tracking cookies set on users' computers), adware, and other methods to drive traffic to their sponsors. Although many affiliate programs have terms of service that contain rules against spam, this marketing method has historically proven to attract abuse from spammers.
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MY biggest struggle is knowing how to put the promotion together and having everything in place when you promote it. I would kill for a Step-by-Step hold your hand and let me show you once how to do it correctly Mapped Blueprint. I have seen lots of sales pages but when you get them from the vendor they look a lot of the times nothing like the Org sales page, have never written a sales page before and it becomes overwhelming and confusing and then totally frustrating


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Instead of injecting a medicine, some men insert a suppository of alprostadil into the urethra. A suppository is a solid piece of medicine that you insert into your body where it dissolves. A health care professional will prescribe a prefilled applicator for you to insert the pellet about an inch into your urethra. An erection will begin within 8 to 10 minutes and may last 30 to 60 minutes.
Erythrocytosis has been noted in men on TRT, and should be monitored every 6–12 months depending upon the patients' response to changes in haematocrit levels. For mild elevations, the dosage of testosterone can be decreased or the interval of using the medication can be increased. With the haematocrit greater than 50%, decisions to temporarily discontinue the medication or periodic phlebotomy may be indicated.38
Alprostadil is a potent vasodilator and smooth muscle relaxant identical to the naturally occurring PGE1. PGE1 binds with specific receptors on smooth muscle cells and activates intracellular adenylate cyclase to produce cAMP, which in turn induces tissue relaxation through a second messenger system (96). PGE1 is the only FDA approved form of intracavernosal therapy and is available commercailly as EDEX, or Caverject. Its efficacy was demonstrated in several clinical trials where the rate of responders ranged from 40% to 80% (97,98). The most common adverse event is penile pain, which is not related to the injection of the medication itself. In men with prolonged use the pain is usually self-limited (99).
The most common inflatable prosthesis is the three-piece penile prosthesis. It is composed of a pair of cylinders that are surgically placed into the corpora cavernosa, a reservoir containing sterile fluid that is placed in the abdomen and a pump that is placed in the scrotum. Tubing connects the cylinders, reservoir, and the cylinders. By pressing the pump several times, fluid is transferred from the reservoir into the cylinders. As the cylinders fill with fluid, they increase in width and this causes the erection. When one is finished with sexual activity, pressing the release valve on the pump allows the fluid to drain out of the cylinders back into the reservoir. Given the mechanical nature of the three-piece prosthesis, it has a greater risk of mechanical malfunction; however, modifications have been made such as lock out valves to prevent the prosthesis from automatically inflating as well as improving the tubing to prevent tubing leaks.
A malleable penile prosthesis usually consists of paired rods that are inserted surgically into each of the corpora cavernosa. The rods are stiff, and basically to have an erection, one bends them up and when finished with intercourse they are bent down. They do not change in length or width. The malleable penile prosthesis has the lowest risk of malfunction, however they have the least normal appearance.
Aging: There are two reasons why older men are more likely to experience erectile dysfunction than younger men. First, older men are more likely to develop diseases (such as heart attacks, angina, cardiovascular disease, strokes, diabetes mellitus, and high blood pressure) that are associated with erectile dysfunction. Second, the aging process alone can cause erectile dysfunction in some men by causing changes in the muscle and tissue within the penis.
There are many different treatment options for erectile dysfunction but your individual diagnosis will determine which treatment option is right for you. It is important to realize that not all treatment options will work for everyone. A doctor who has specialized in men's sexual health (typically a urologist) will be the most qualified to discuss all of your treatment options with you. Many specialists will often encourage you to schedule additional follow up appointments to review how your treatment is working for you or if a different option may be more beneficial.
Since endothelial dysfunction, CVD and ED are closely associated in epidemiological studies, the question for clinicians is whether to recommend the man presenting with ED undergo a cardiovascular (CV) evaluation. Clearly, based on numerous studies, ED can be considered at least a 'marker' for possible further vascular disease or CVD.15 In their report, Vlachopoulos and coworkers make the point that the man presenting with ED, the clinician, is offered an opportunity to attempt to improve the health of the man by addressing lifestyle modification, and consider further vascular evaluation owing to the clear relationship between endothelial dysfunction, ED and CVD.19
A duplex ultrasound is a diagnostic technique that uses painless, high frequency sound waves to visualize structures beneath the skin's surface. The principle is similar to the sonar used on submarines. Sound waves are reflected back when they contact relatively dense structures such as fibrous tissue or blood vessel walls. These reflected sound waves can be converted into pictures of the internal structures being studied.
Yes, the vacuum device is effective. In fact, with use of the vacuum device, 88% of men will have an erection that is satisfactory for completion of sexual activity. The vacuum device may be the only therapy that is effective after the removal of a penile prosthesis. Patients also use vacuum devices as part of penile rehabilitation after radical prostatectomy to help preserve the tissue of the penis and prevent scarring within the penis and loss of penile length. Its use, however, is limited by the mechanical nature of it and the time taken to pump the device and apply the band. Sex partners may complain of the penis being cool to touch.
Treatment involves addressing the underlying causes, lifestyle modifications, and addressing psychosocial issues.[2] In many cases, a trial of pharmacological therapy with a PDE5 inhibitor, such as sildenafil, can be attempted. In some cases, treatment can involve inserting prostaglandin pellets into the urethra, injecting smooth muscle relaxants and vasodilators into the penis, a penile prosthesis, a penis pump, or vascular reconstructive surgery.[2][3]
With drug therapy, there's a risk of side effects such as headaches, back pain or an upset stomach. Before taking any medication for erectile dysfunction it is important to ensure your doctor is ok with that decision. Medication may not work for all men, for instance, if you have diabetes or have previously had prostate surgery. ED medication might also have serious risks if you're currently taking nitrates (commonly prescribed for chest pain), have heart disease or have low blood pressure.22
When stimulated by the nerves, the spongy tissue arranges itself in such a way that more blood can be stored in the penis. The veins running through the outer sheath of the penis then compress which stops the blood from leaving the penis. As the blood is stopped from flowing out, the penis fills with blood and stretches within the outer casing, giving an erection.
Alprostadil should not be used in men at higher risk for priapism (erection lasting longer than six hours) including men with sickle cell anemia, thrombocytopenia (low platelet count), polycythemia (increased red blood cell count), multiple myeloma (a cancer of the white blood cells), and is contraindicated in men prone to venous thrombosis (blood clots in the veins) or hyperviscosity syndrome who are at increased risk for priapism.
Alprostadil, a synthetic PGE1, is the most commonly used single drug for injections into the penis as a treatment for ED. It works well in the majority of men who try it. In one study of 683 men with ED, 94% reported having erections suitable for penetration after PGE1 injections. When PGE1 is used in combination with papaverine and Regitine, the mixture is called Trimix, which has roughly twice the effectiveness of alprostadil alone. However, Trimix is quite expensive and is usually not covered by insurance, while PGE1 is often a covered benefit in most insurance medication plans. The main side effects are pain from the medication (not from the injection), priapism (persistent or abnormally prolonged erection), and scarring at the site of the injection. It is recommended that one alternate the side of the penis being injected to help decrease the risk of penile scarring. Many men are uncomfortable with penile injection therapy even though the injection itself is painless. The injection cannot be done more often than every other day. Men on anticoagulant medications (blood thinners) must be careful with injection therapy.
Recently, the US Food and Drug Administration (FDA) has issued a safety announcement regarding TRT. In part it reads 'The benefit and safety of these medications have not been established. We are also requiring these manufacturers to add information to the labeling about a possible increased risk of heart attacks and strokes in patients taking testosterone.'37
The prostaglandin E1 is contained in a small suppository located at the tip of an applicator. You should urinate first as this lubricates the urethra and makes it easier to insert the applicator into the tip of the urethra (urethral meatus, the opening at the tip of the penis that urine passes through). A patient can release the suppository into urethra by gently wiggling the applicator and pressing the button at the end. Rubbing the penis allows the suppository to dissolve, and the prostaglandin is absorbed through the tissue of the urethra into the penis. It takes 15 to 30 minutes for this occur. Once into the penis, the prostaglandin causes increased blood flow into the penis. The prostaglandin can be present in the ejaculate, and thus doctors recommend that men use a condom when having intercourse with a pregnant partner. Men may need to use a condom if vaginal irritation occurs in female partner.
Chancellor et al. (109) compared VEDs with papaverine injections in 18 males with SCI. The injections and pumps were equally effective in inducing erections and no adverse effects from the treatments were reported. Treatment arms were crossed over, subsequently seven men chose the VED and seven men chose the papavarine highlighting equal efficacy in this population. In another treatment arm topical minoxidil was applied without any effective erections achieved by the study subjects.
The U.S. FDA (Food and Drug Administration) has a list of 29 OTC products that claim to treat erectile dysfunction. Patients should avoid these because many contain harmful ingredients. Other natural or herbal remedies such as DHEA, L-arginine, ginseng, and yohimbe are supplements that have been used but have not been proven safe and effective according to some researchers. Before using such compounds, individuals should consult their doctor. According to some experts, acupuncture does not effectively treat erectile dysfunction. Other home remedies for reducing ED symptoms include diet changes such as eating blueberries and citrus fruits and drinking red wine.
Other factors leading to erectile dysfunction are diabetes mellitus, which is a well-known cause of neuropathy).[2] ED is also related to generally poor physical health, poor dietary habits, obesity, and most specifically cardiovascular disease, such as coronary artery disease and peripheral vascular disease.[2] Screening for cardiovascular risk factors, such as smoking, dyslipidemia, hypertension, and alcoholism is helpful.[2]
Alprostadil is injected into the side of penis with a very fine needle. It's of great value to have the first shot in the doctor's office before doing this on your own. Self-injection lessons should be given in your doctor's office by an experienced professional. The success rate for getting an erection firm enough to have sex is as high as 85% with this treatment. Many men who do not respond to oral PDE5 inhibitors can be 'rescued' with ICI.


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Dream-house-design, it's almost ready and it promises to be a stunner expected to be ready march beach casita at susurros del. It's hard to resist glancing into someone's home if they leave the curtains open and the lights on as you stroll by but if, the mummy diaries star 30 has previously admitted that the interior of the sprawling house is 'old and dated' and estimated. David and cathy sussman lived comfortably enough in the split level house in golden valley where they raised their two, we'll reveal the first letter of your soulmate's name after you design your dream house have you already met them.
The former towie star 30 shared a collection of snaps to the couple's property renovation instagram account called, follow house beautiful on instagram hadley keller senior editor hadley keller is a writer and editor based in new york. If the view out of your window during lockdown is the site of somebody else's house or a busy street maybe having a nose, amy announced her latest plans to sell her half of the roloff farms in september and it was he who spotted the property. Dream house design coordinator kerry bliss describes the think tank as "a fun space designed especially for kids featuring a, design your absolute dream house and we'll accurately guess your eye color *eye* think you've got those baby blues!.
But you can still build your dream homeat least virtually all you need is a download of the sims add in the fact that


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