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Lester Holt, Savannah Guthrie, Chuck Todd and Megyn Kelly Lead Network Coverage Beginning at 8:00 p.m. ET
Brian Williams and Rachel Maddow Anchor MSNBC's Primetime Coverage Beginning at 6:00 p.m. ET
NBC News Digital will Livestream Coverage Across Apps and Platforms
OCTOBER 10, 2018 – NBC News and MSNBC will broadcast live coverage of the 2018 midterm elections, The Vote: America's Future, anchored from NBC News world headquarters in New York City on Tuesday, November 6. Rockefeller Plaza will once again light up for Democracy Plaza, with programming streaming on screens flanking the building and augmented graphics showing vote counts and poll results projected against the building for television viewers.
NBC Nightly News anchor Lester Holt and TODAY co-anchor Savannah Guthrie lead the network's coverage joined by Meet the Press moderator and NBC News political director Chuck Todd and Megyn Kelly TODAY host Megyn Kelly. Coverage will air live from:
- 8:00pm – 11:00 p.m. ET
- 7:00pm – 10:00 p.m. CT
- 7:00pm – 10:00 p.m. MT
- 8:00pm – 11:00 p.m. PT
- The eastern and central time zones will receive additional updates after local news
On Sunday, November 4, Meet the Press with Chuck Todd originates live from NBC News Election Headquarters in New York with an all-star political panel of NBC News and MSNBC anchors and contributors. TODAY will provide full coverage with Savannah Guthrie and Hoda Kotb on Election Day and the morning after. NBC Nightly News with Lester Holt broadcasts from NBC News Election Headquarters on Monday, November 5 and Tuesday, November 6.
MSNBC coverage begins with Morning Joe and continues through MSNBC dayside and primetime. Starting at 6:00 p.m. ET, Brian Williams, host of The 11th Hour with Brian Williams, and Rachel Maddow, host of The Rachel Maddow Show, will helm election night primetime coverage on MSNBC with NBC News and MSNBC national political correspondent Steve Kornacki at the "Big Board." They will be joined throughout the night by Deadline: White House's Nicolle Wallace, Hardball's Chris Matthews, All In's Chris Hayes, The Last Word's Lawrence O'Donnell, and MSNBC political analyst Eugene Robinson.
Kornacki will be on set breaking down the details of key races with his now famous "Big Board," which re-launched with an all-new look using cutting-edge software developed by the NBC News Digital product and technology teams. MSNBC anchor Stephanie Ruhle will host a pre-show airing across all NBC News digital properties from 7 p.m. ET – 9 p.m. ET, with NBC News coverage simulcasting afterward and through the night.
NBC News correspondents Catie Beck, Garrett Haake, Kasie Hunt, Chris Jansing, Steve Patterson, Cal Perry, Morgan Radford, Gadi Schwartz, and Jacob Soboroff as well as NBC News political reporters Shaquille Brewster, Leigh Ann Caldwell, Vaughn Hillyard, Mike Memoli, Heidi Przybyla, and Ali Vitali will report live from key locations across the country, focusing on the candidates and the crucial issues impacted by 2018 midterm results. NBC News senior legal and investigative correspondent Cynthia McFadden will embed with the NBC News VoteWatch team reporting on election security.
NBC News Digital's full politics team will be providing coverage of the race results and ballot initiatives across the country. They'll offer exit poll data and analysis on the consequences for the President and each party and will also provide live blog coverage of the night. NBC Social teams will be live on Twitter, Instagram and Facebook with race results, data, speeches and on-the-ground updates from NBC News reporters around the country. And, NBC's Stay Tuned will be covering the races with additional breaking news updates to their show throughout the night.
Digital will also showcase a new interactive map on NBCNews.com powered by the same technology used by Kornacki and Todd, allowing viewers to follow the vote count on television and on their own by selecting district combinations to see how the balance of power in the House may shift.
More Americans watch NBC News and MSNBC than any news organization in the world. NBC News is a global leader in news across all broadcast and digital platforms. Its leading and award-winning television news broadcasts include "NBC Nightly News with Lester Holt," "TODAY," "Meet the Press with Chuck Todd," "Dateline NBC," "Sunday Night with Megyn Kelly" and "Megyn Kelly TODAY" as well as primetime specials and breaking news reports. For the 2017-2018 season, all four NBC News broadcasts were #1 in the key news demo for the second year in a row. MSNBC is the premier cable destination for breaking and live news coverage, in-depth analysis, and influential voices – 24 hours a day, 7 days a week. The rapidly-growing NBC News Digital Group, along with the SiriusXM TODAY Show and MSNBC radio channels and NBC News Radio on the iHeartMedia 24/7 News Network, provide continuous content to consumers wherever they are, whenever they want it.
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| 7.3°C Dublin
Weather-wise, the good Lord has a conscience. After sending us one of the worst years ever for mid-season lambing last year, he now sends us one of the best years on record.
It made it much easier to get out of bed during the night and up early in the morning. Lambs could be let out quickly and there was some grass, particularly on fields that were closed early and fertilised.
Sheep farmers should review their lambing management and, in doing so, concentrate on the one or two issues that gave rise to most problems.
I will give a little rundown on the problems we encountered over the last two years. A reasonably high proportion of the flock has triplets and the lambs are reared on the ewes. During the first few days, we tend to top up small triplet lambs with milk replacer so that they can compete with their siblings on let-out.
The major problem encountered last year related to the use of an untried and untested milk replacer. Lambs became bloated, were unable to defecate and basically developed symptoms resembling watery mouth, even though they had received ample colostrum. It took a while (as well as visits to the vet) to figure out what was wrong, but once we reverted to the traditional milk replacer, the problem ceased.
With all the legislation, I find it difficult to understand how companies can market such products without some independent research. I, for my part, should have concentrated a little more on the words of Alexander Pope when going to school: "Be not the first by whom the New are try'd, Nor yet the last to lay the Old aside."
This year, the problems were not on the same scale, but nevertheless some were most annoying. A number of ewes were lost through prolapsing the intestines through the vaginal wall. Nobody seems to know the underlying reasons behind this condition. It is generally a sporadic condition but from the number of calls I received over the last number of months there seems to have been a higher incidence of it this year.
Some of the pre-disposing factors postulated include: association with vaginal prolapse, overfat ewes, high meal levels, triplet pregnancies and adhesions or damage from a previous difficult lambing. Should anybody have their own particular theory or ways of preventing this condition we would all be particularly interested in hearing it.
This brings me to the two most annoying conditions that occurred this year -- inturned eyelids (entropion) and crooked or contracted tendons (arthrogryposis). We have had some incidences of these conditions most years, but there was a significant increase in the incidence of entropion this year. It was mostly confined to the progeny of one or both of two Charollais rams that I purchased last autumn.
Contracted tendons is often associated with the progeny of Suffolk rams and is quite common in some pedigree flocks of the breed. It results in lambs walking on their fetlocks.
These conditions are a real nuisance, as they require time to treat and can result in a two to five-day delay in letting out. Where triplet lambs are being retained on the ewe, they can be a real disaster. Lambs with inturned eyelids (particularly both eyes) seem to spend a lot of their time lying down, while those with contracted tendons cannot keep pace with their siblings and are likely to perish.
On the positive side, both conditions are inherited and so can be easily eliminated. Unfortunately, there is no blood test available yet for either condition. The only option available is for breeders to keep accurate records and to cull rams that produce offspring with these conditions.
I would suggest that Sheep Ireland should incorporate these conditions (particularly entropion) as part of their sheep breeding programmes. I may be wrong (I have no figures) but the incidences of entropion seem to have increased significantly since the 1980s.
Andrew Kinsella is a Wicklow sheep farmer and a former Teagasc sheep specialist
Indo Farming

subset: commoncrawl


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Marietta's New Theatre in the Square
Marietta's New Theatre in the Square Tickets and Event Schedule
Apr 10Friday, Apr 10, 2020 / 8:00pm
Apr 11Saturday, Apr 11, 2020 / 7:30pm
Apr 15Wednesday, Apr 15, 2020 / 11:00am
Apr 17Friday, Apr 17, 2020 / 8:00pm
Apr 18Saturday, Apr 18, 2020 / 7:30pm
Apr 19Sunday, Apr 19, 2020 / 2:30pm
Apr 22Wednesday, Apr 22, 2020 / 11:00am
Apr 24Friday, Apr 24, 2020 / 8:00pm
Apr 25Saturday, Apr 25, 2020 / 7:30pm
Venue Information
Accessible or ADA seating may be available at this venue through Goldstar. Contact us before buying tickets to make arrangements.
Seating Charts
72 Marietta's New Theatre in the Square Tips
- Casual 2
- Dressy 2
- Parking is free 1
- Arrive early 1
- Parking is scarce 1
- Dine before you go 4
- Food and drinks for purchase 2
The weather was Cool.. I wore Dress is business casual. .
Only snacks & drinks are available. So, Eat before you go.
Parking is scarce closet to the venue, so one would have to pay up to $5 to park about 2 streets away and walk to the theater.
Beware parking has apparently always been a challenge during peak times (like evenings/nights during weekend) for the entire area of Marietta Square, at no fault of this theater. However, there is a larger parking lot north west and a public deck north east of this theater. Both options are just a couple blocks walk.
I ate at Hemingway's right around the corner. I recommend it
The weather was A little windy and cool. I wore Sweater and a jacket with a nice pair of pants and boots. I even wore a hat to jazz it up!!.
Lots of neat places on the square to eat. We ate salads at the Taqueria Tsunami. Service was fast and food delicious


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Ivagalane population isolated by collapsed bridge, students cut off from school - Watch
Photo: TVM
Police in Mozambique scuttled an attempt to traffic 42 illegal migrants from Malawi in a container lorry heading to South Africa.
They had been travelling in the lorry for three days before being intercepted in the capital of Gaza province, Xai-Xai, police spokesman Carlos Macuacua said.
The detained migrants told authorities they had been assured of employment in South Africa.
Police are working with the Mozambique migration authorities to repatriate them to Malawi, Mr Macuacua said:
" This is an illegal immigration case. They hold no identity cards and they were being carried in inhumane conditions.
"There's work still to be done together with the immigration authorities and the national investigation service to find out the true masterminds of this trafficking."Source: BBC
Mozambique: Nyusi urged to declare state of emergency - AIM report
Covid-19: new study shows rapid action needed to prevent many deaths - By Joseph ...


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Unit 91 - 1086 Heyward Way, Alpharetta
Absolutely beautiful townhome within short walking distance to Downtown Alpharetta and Avalon. End unit with private, charming courtyard. Upgrades and updates throughout. Neutral paint colors, dark hardwoods, plantation shutters and premium finishes. Delightful granite/stainless kitchen has many extras including dishwasher drawers, warming oven and wine cooler. 2 story-light filled great room with French doors and adjoining dining room makes a delightful entertainment space. Extra wide staircase, halls and doorways. Master suite features private balcony, custom closet, built-ins and spa bath with soaking tub and lovely light granite. Fantastic 3rd floor retreat with full bath. Only townhome in community with elevator closet connecting all 3 floors. Easy to add an elevator or use for lots of extra closet space. Truly stunning, like new townhome located in premier Academy Park gated community with pool, tennis courts, fitness facility and 7 acre nature preserve.
Maintenance Exterior, Maintenance Grounds, Reserve Fund, Swim/Tennis, Termite, Trash
Garage, Auto Garage Door, Garage Faces Front
Bookcases, Cathedral Ceiling(s), Central Vacuum, Double Vanity, Entrance Foyer 2 Story, High Ceilings 10 ft Main, High Speed Internet, Tray Ceiling(s), Walk-In Closet(s), Wet Bar
Dishwasher, Disposal, Gas Cooktop, Gas Water Heater, Microwave, Refrigerator, Self Cleaning Oven
Ceiling Fan(s), Central Air, Zoned
Factory Built, Gas Log, Great Room
Walk out balcony, Walk out courtyard, Private Backyard
Keller Williams Rlty Consultants
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Listing information last updated on March 31st, 2020 at 9:00am EDT.


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Red, White and Brew
400 Landmarks Blvd., Alton, IL 62002
- Presented By: Old Bakery Beer Company
- Dates: July 3, 2020
- Location: Old Bakery Beer Company
- Time: 6:00 PM to 10:00 PM
Kids under 5 free
Mark your calendars for Red, White & Brew, the 6th annual fireworks viewing party at The Old Bakery Beer Company! Tickets are available now at the brewery.
For only $5 you will be guaranteed a seat to view the fireworks, enjoy live music from Big George Jr. and the NGK Band, and have access to Old Bakery Beer and BBQ featuring lots of meat from Hansen Meat Co - Alton and vegetarian options!
Spend your night dancing, playing yard games and enjoying the concessions, and top it off with an amazing view of the Alton fireworks display! We will sell out and suggest picking up your tickets soon!
The party will be in the shared parking lot of The Old Bakery Beer Company and Hansen Meat Co - Alton. In the event of rain, the party will move into the brewery.
Tickets are not required for children under 5. There is no dedicated parking for the event, but we open early so you can beat the traffic and get an early start enjoying your night!
The City of Alton has confirmed that fireworks are planned to be set off from the Illinois side of the river this year. We will have a great view!


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Columbus Fresh 48 Photographer: Baby Savannah
From Ashley + Mike's November 2017 wedding to their recent maternity session, it's been nothing short of a joy coming down to Cincinnati to document all their happy life events! As luck would have it, I was down in Cincinnati again for a wedding at the end of February, and baby Savannah arrived just in…Read More
Columbus Ohio Short North LGTBQ Engagement: Mandy + Rebecca
It was a chilly Friday afternoon in late February when I met up with Mandy + Rebecca in the Short North for their engagement session! I always encourage my clients to pick locations special to them, so they chose to begin our session at a store they visited on their first date: the candy store…Read More
Columbus Ohio Newborn Photographer: Baby Claire
It wasn't too long ago I was celebrating with Kate + Ben at their Sept 2018 wedding, and I was so thrilled when they invited me into their home last month upon the arrival of their baby girl, Claire. It was a Tuesday morning in late February, a couple weeks from when our world changed,…Read More
Columbus Ohio Indian Wedding at the Hilton Polaris: Kelley Jo + Suresh
I couldn't think a better way to kick off the 2020 season of weddings, than with Kelley Jo + Suresh's winter celebration! Their January Indian-fusion wedding was as colorful as it was full of energy, a non-stop party from beginning to end! The celebration began at their Sangeet the night before the wedding at the…Read More
Columbus Ohio Maternity Session in the Short North: Danielle + Troy
It's been over 6 years since I photographed Danielle + Troy's engagement session in the Short North (and later their wedding). So you can imagine how excited I was to hear from them that not only were they expecting, but they wanted to return to the Short North neighborhood for maternity portraits! We met up…Read More
Columbus Ohio Surprise Proposal: Mallary + Conor
It was two days after Valentine's Day, a beautiful sunny Sunday evening in mid-February, when Conor took Mallary on date in downtown Columbus. She knew they dinner reservations at Milestone 229, but he parked across the water, forcing them to walk the bridge first. It on that bridge at Scioto Mile that I was waiting…Read More
German Village LGBTQ Anniversary Session: Erin + Jenn
It's Valentine's Day, the day of LOVE! So what better way to celebrate than to blog my recent anniversary session with Erin and Jenn? I met the two of them at Jill and Rob's elopement this past May. As it turned out, we had tons of friends in common (got to see them again at…Read More
Cincinnati Maternity Session: Ashley + Mike + Family
It's been three years since I shot Ashley + Mike's Cincinnati wedding. We've stayed in touch since, and when Ashley reached out to share the news that she and Mike were expecting, I was so thrilled for them! And I was even more thrilled when they asked me to return to Cincinnati to shoot their…Read More
Columbus Zoo Portrait Photographer: Cynthea + Sylvester
Cynthea + Sylvester's Columbus Zoo wedding was just about 5 years ago, when I heard from them, wanting to do a couples session! While it seemed like the original intention was just to get some updated portraits together, the timing worked out perfectly that we were so close to their wedding anniversary. For their session,…Read More
Columbus Ohio Thai-Chinese Wedding at Noah's: Alita + Joel
Alita + Joel's wedding was so awesome, it warranted not one set of attire, but two! Their mid-November day started with a morning Thai-Chinese tea ceremony at Alita's parents' Blacklick home, followed by lunch and a break, and ended with an outfit change into Western attire for their evening reception at Noah's New Albany. It…Read More


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Explore Gallery of Diamond Layered Anniversary Ring In White Gold
Showing Photo About Engagement Rings & Fine Jewelry | Diamond Wedding Rings Pertaining to 2019 Diamond Layered Anniversary Ring In White Gold
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Now that the high season for power boating has passed, it is a great time to kayak in Boston Harbor. The weather and water is still warm and the number of boats clogging the channels is manageable.
I was going to lead a RICKA paddle to the outer islands yesterday. I was excited to share one of my local resources with my RI friends. Sadly, the wind forecast was extreme. 15 to 20 in the outer harbor is a little rough, but 30 knt gusts are crazy. So, I decided to cancel the paddle.
Fortunately, the winds were forecasted to die over night. 5 knt winds are perfect for a late fall paddle. So, I decided to reschedule the paddle for today.
The morning was bright, but chilly. The day was looking like a great day to paddle.
The only anxiety was about who would show up for the paddle. I knew most of the regular crew would not show up. They all had other commitments. The absolute worst that could happen was the H and I would have to enjoy the water by ourselves. You know life is good when the absolute worst outcome is spending the day paddling with your favorite person.
On the way to Hull we spotted at least two familiar kayaks. Once at the put-in we discovered six more paddlers. There were two familiar faces, two faces I hadn't seen in a long time, and four new faces. The group seemed to gel before we even got on the water.
The plan for the day was to paddle out to Little Brewster and check out the light house. Then we'd island hop over to Green Island for lunch. After lunch, we'd island hop over to Georges Island to check out Ft. Warren. Then we'd return to Hull.
This was a great plan based on us launching at mid-tide on an out going tide. Sadly, I'd gotten the tides backwards. We'd have the currents against us all day.
To make the crossing to the light house we paddled out to Allerton Point. From there we crossed the channel on a steep ferry angle. The incoming tide pushed us down the channel as we aimed our kayaks out of the harbor. We managed to pick the perfect angle and ended up along Little Brewster. We landed to take a tour of the light house, but it is being repaired. We were allowed to walk the grounds. It was a quick tour because the tide was raising fast. We didn't have much time before our kayaks were heading to Green Island without us.
We got to Green about 40 minutes before high tide. We paddled the island looking for the beach to land and have lunch. I knew it was there because I had lunched there this past winter... We must have landed there closer to low tide in Febuary because the beach was a tiny patch of rocks.
The best we could find for lunch was a disappearing pile of rocks between Green and Little Calf. We had an authentic sea kayaking lunch hunkered down watching the tide wash over our beach.
After lunch, we paddled over to Georges Island. Crossing the channel was exciting. There was a surprising amount of boat traffic.
At Georges Island, we took an extended break. Some people explored the fort, some people napped, and some just hung out on the beach.
From Georges Island, we made our way back to Hull. We had a long channel crossing and the Hull Gut to contend with before we were home. The current was against us and running at full strength.
For the crossing, the current was no big deal. However, the Gut was a challenge. The current was stacking up with a row of standing waves. These were confused by the boat traffic plying the Gut. Sticking close to shore would keep us out of the worst of the current. Sadly, none of us stayed close to shore. H nearly went over. I got spun around once. It was a lot of fun.
Despite the less than ideal planning, we had a nice time. The weather was perfect and the group was excellent. It goes to show that waiting a day for the wind to blow over is a good idea.
Sunday, September 20, 2009
Letting the Wind Pass
Now that the high season for power boating has passed, it is a great time to kayak in Boston Harbor. The weather and water is still warm and the number of boats clogging the channels is manageable.
Labels: Boston Harbor, Hull, Massachusetts


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Total Construction Services, Inc.
6727 North 56th Street
Omaha NE 68152-2308
About Us
Our goal at Total Construction Services is to combine experience and quality to provide solutions and value for our customers in need of restoration, roofing, remodeling, mold remediation and insurance claim services. The ability to meet the individual needs of our customer sets us apart from the competition. Unlike other contracting companies, we offer services in a wide variety of areas, so come see for yourself how we can help your home or business improvement project.


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Cable hdmi a vga mac mini
Great bit of kit. Performs without any issues and is really versatile with all the different outputs. Currently unavailable.
Mini DVI to DVI Adapter
An affordable and good quality cable, compared to the rate you can purchase them at a fraction of the price of an Apple cable. The product does exactly what it is supposed to. I have used it to connect my MacBook Air to a Smart Sony TV and it works perfectly; transferring the picture and sound in perfect quality-there is no diminished quality or resolution in the picture.
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Note: I need to select the TV as the speaker output on the Sounds menu in System Preferences on the macbook each time I plug it in to get the sound to come out of the TV. Obviously this has nothing to do with the product but is something to bear in mind if you're buying it for a similar purpose! Only 14 left in stock. The cable works fine and looks as if it should work for a long time as the braided outer covering looks strong. I bought this product for use with my Surface Pro 3 to be able to extend and duplicate the screen to my TV.
It is of good length for me, and I have seen no issues with the output on the screen. Excellent Purchase would recommend. Worth the money!!
How to connect external displays to a 2017 MacBook Pro
Good device for the cost!! It works like a charm!! Works very well with my MacBook Air. Unlimited One-Day Delivery and more. KSh 1, Buy now Save for later.
conversion - Apple Mac Mini won't work with HDMI to VGA converter - Super User
Machakos 4 - 7 6 - 9 31 - 34 Jumia Express is available only for items with the logo. Click here for more information Delivery times are business days only, and do not include Sunday. Warranty See more details about warranty here. Jumia Global.
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Search and compare thousands of words and phrases in British Sign Language (BSL). The largest collection online.
How to sign: call forth (emotions, feelings, and responses)
"arouse pity"; "raise a smile"; "evoke sympathy";
Similiar / Same: arouse, evoke, provoke, enkindle, kindle, fire, raise
Within this category: strike a chord, invite, draw, rekindle, infatuate, prick, inflame, stimulate, excite, anger, upset, shame, hurt, overwhelm, interest


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Ford Explorer XLT
The 2020 Ford Explorer. It features four-wheel drive capabilities, a durable automatic transmission, and a 2.3 liter 4 cylinder engine. Turbocharger technology provides forced air induction, enhancing performance while preserving fuel economy. A wealth of standard features means that you no longer have to sacrifice. Like power windows, mirrors, and seats, 1-touch window functionality, a trip computer, automatic temperature control, a power liftgate, lane departure warning, remote keyless entry, and more. Third row seats provide an even greater maximum passenger capacity. Audio features include an AM/FM radio, steering wheel mounted audio controls, and 6 speakers, enhancing the audio experience throughout the interior. Ford ensures the safety and security of its passengers with equipment such as: dual front impact airbags, front side impact airbags, traction control, brake assist, a panic alarm, an emergency communication system, and 4 wheel disc brakes with ABS. Various mechanical systems are monitored by electronic stability control, keeping you on your intended path. This vehicle has achieved Certified Pre-Owned status, by passing Ford's rigorous certification process. We have the vehicle you've been searching for at a price you can afford. Please don't hesitate to give us a call.


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Yes, there are multiple flights from Johannesburg to Frankfurt for under R9 700. The cheapest flight booked recently is on Air Namibia for just R9 692, but on average you can expect to pay R10 113.
Cheapflights has 2 direct flights from Johannesburg to Frankfurt under R11 200. A good price for a non-stop flight from Johannesburg to Frankfurt is less than R11 146.
There are currently just 3 open flights from Johannesburg to Frankfurt within the next 7 days for less than R9 900.
Within the past month, 4 565 users have taken a look at flights from Johannesburg OR Tambo to Frankfurt am Main.
Expect the weather to be around 26 °C on average in January. As the temperature peaks, try to get your plans done early, as flight price and availability will have an impact on your travels. The climate in Frankfurt is generally colder than in Johannesburg.


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If you are using Dynamic Data in ASP.NET to generate some basic entry web site you will get this error if you publish your web site and you have a form with the same name as a table in you data context class. e.g. Order.aspx and System.Data.Linq.Table Order.No problem when running fron VS which sent me up the wrong path initially … [Read more...] about CS0433
Silverlight Talk
Paul Walsh of Torc Software gave a great talk on Silverlight applications last night. Paul is a regular attendee at the MTUG talks and we had a good turnout with some good interaction.Hopefully we can get some more members to give talks to their local groups. … [Read more...] about Silverlight Talk
WWF Jon Flanders
Jon Flanders gave a great talk to the Cork MTUG user group on Windows Workflow. Very well attended and great feedback on Jon. … [Read more...] about WWF Jon Flanders


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Telecom Technician Schaumburg, Illinois
Opportunity :
Parsons is now hiring for a Telecom Technician to support operations at our Schaumburg, Illinois office. Ready to put your skills to work on Technical projects?
Are you great with people and have willingness to work hard to get the job done? Parsons is seeking a candidate with a desire to enhance the fabric of our community.
Under the general supervision, provides physical installation and functional test of (Switching) equipment projects in a field environment. Position requires 95% travel, and the ability to work overtime and/or nights as required.
The technician will install equipment in field cabinets, connect equipment to antennas, configure network equipment, run tests, and prepare technical documentation under the supervision of an engineer.
Responsible for cable fabrication, installation and testing.
Handles MOP creation/execution.
Handles on-site material inventory and management of equipment.
Assists in daily reporting, documenting out of scope tasks as change orders, reporting and tracking material discrepancies, and solving technical issues/problems.
Assists in clearance of audit and punch list items.
Completes progress reporting for project assignments and material discrepancies.
Escalates project delays, customer concerns and/or complaints to immediate supervisor.
Performs other responsibilities associated with this position as may be appropriate.
High School degree or GED required; ASEE or BSEE (or related field) preferred and typically 2+ years progressive telecommunications installation and testing experience. Basic Datacom and IP experience preferred.
Working knowledge and skills in use of computer systems.
Ability to read cable color-codes as well as use hand and power tools.
Valid driver's license.
Ability to lift and carry 75 lbs.
Basic technical knowledge of telecom products.
Ability to follow verbal and written work instruction / product documentation.
Ability to work in standing, sitting, kneeling positions.
Ability to climb ladders.
Ready for action? We're looking for the kind of people who see this opportunity and don't hesitate to act.
Parsons is a leader in the world of Technical Services and Engineering. We hire people with a broad set of technical skills who have proven experience tackling some of the greatest challenges. Take your next step and apply today.
Parsons Commercial Technology Group Inc.


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Newspaper headlines: Coal fire crackdown and London mosque stabbing
"The end of the roaring hearth" is how the Daily Telegraph views the impending ban on coal and certain types of wood to heat our homes.
It believes the government risks accusations that it is targeting consumers rather than industry in its efforts to cut emissions.
The paper calls the measure "hasty" and says it is sadly reflective of an age in which – instead of trusting individuals to make the right decisions – "bans are politicians' first and only weapon of choice".
The i newspaper – which also leads on the story – declares that cosy winter nights spent around a glowing fire are set to be consigned to the history books.
"Two faces of hatred" is the Daily Mail's headline above reports on the murder of nine people at shisha bars in Germany by a right-wing extremist – and the knife attack at a mosque in London.
The right-wing terror threat is, says the Daily Mirror, an evil we all must fight. The paper depicts the German gunman as a "deranged racist" who ranted about wiping out entire nations.
The Telegraph says Muslims here have called for tighter security after a muezzin – a person who makes the call to prayer – was stabbed at London Central Mosque, near Regent's Park.
Meanwhile, the Mail uses an editorial to urge the prime minister to take a few hours out of his busy schedule to commiserate personally with people forced from their homes by flooding.
This should be Boris at his bouncing best, it says, cheering people up and assuring them that their problems are his problems. Yet his wellingtons and waxed sou'wester have stayed firmly in the cupboard.
The Daily Express highlights what it describes as "Britain's soft justice system" which it says has been laid bare by three burglars who were not sent to prison – despite carrying out 75 break-ins.
The paper says the gang were given non-custodial sentences until the final offence, when one was handed a suspended jail term.
It argues that criminals escaping justice is deeply disturbing and feeds a loss of confidence in the justice system.
Airbnb analysis
The Guardian reports that Airbnb has become so prevalent in Britain that some parts of the country now have one listing for every four properties.
It says this has prompted warnings that the rapid expansion in short-term lets is "out of control" and depriving communities of homes.
Edinburgh Old Town has the highest incidence, with 29 active listings for every 100 homes, while the north-west of Skye has 25 per 100.
Airbnb has questioned the accuracy of the figures and said unusual listings, for example caravans, do not affect local housing stock.
Get news from the BBC in your inbox, each weekday morning
In its main story, the Times claims that an unpublished report on the Home Office's "hostile environment policy" towards migrants has been toned down after originally concluding that the department was "institutionally racist".
It says the term was in an earlier draft of the Windrush review into the treatment of people from the Caribbean, but doesn't appear in more recent versions.
The paper says there are concerns in Whitehall that members of the advisory panel which helped to write the review will go public and criticise the government if the report is subjected to significant changes.
The Home Office said it had not had the final report and ministers had not seen any version of it.
"Dangers lurking in your toxic takeaway" is the less than appetising headline in the Daily Mail.
The paper highlights research which found that 380,000 cases of foodborne illness a year are caused by norovirus – with almost two thirds linked to eating out or takeaway meals.
It says the figures come amid concern about a collapse in the number of hygiene checks carried out by local councils on restaurant and takeaway premises following savage budget cuts.
In another health story, the Guardian reports the news that scientists using artificial intelligence have developed a powerful antibiotic that kills some of the most dangerous drug-resistant bacteria.
The Financial Times believes the breakthrough signals a significant new tool in the global fight against drug resistance.
End of EastEnders era
The Sun describes it as a watershed moment for the world of soap – a decision by the 93-year-old actress, June Brown, to quit EastEnders after 35 years as the chain-smoking gossip, Dot Cotton.
In a podcast interview picked up by the paper, she says leaving Albert Square is "almost like being bereaved".
The paper says it followed "disappointment" by the veteran star with her recent storylines.
Finally, several papers publish two pencil sketches which are believed to have been drawn by the Queen when she was a child.
One shows a middle-aged woman in profile – possibly her nanny, "Crawfie" – while the other seems to be of the same person knitting.
Buckingham Palace hasn't said whether the works are genuine.
But one art critic tells the Mirror that if the sketches are by the Queen, they show a precocious talent that – had she not become sovereign – could have taken her in artistic directions.


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Bear, Joseph C., Cockcroft, Jeremy K. and Williams, Jeffrey H. (2020) Influence of solvent in crystal engineering : a significant change to the order–disorder transition in ferrocene. Journal of the American Chemical Society, 142(4), pp. 1731-1734. ISSN (print) 0002-7863Full text not available from this archive.
We present the structure of a novel solvate adduct formed by dissolving ferrocene, FeCp2, in hexafluorobenzene, C6F6. This adduct demonstrates the remarkably strong interactions between the five-membered aromatic rings of FeCp2 and the six-membered aromatic ring of C6F6. These molecular interactions are sufficiently strong and anisotropic to change the temperature of the order–disorder transition of the ferrocene molecule from below ca. 164 K to RT. No solvate adduct could be formed between benzene and FeCp2. These observations will be of particular relevance to the crystal engineering community, whose goal is the design of solids with bespoke properties.
|Item Type:
|Additional Information:
|This work was supported by the Engineering and Physical Sciences Research Council [grant number: EP/K03930X/1] and Kingston University [grant number: P1305-103].
|Uncontrolled Keywords:
|Adducts; Molecules; Sandwich compounds; Aromatic compounds; Molecular structure
|Research Area:
|Chemical engineering
|Faculty, School or Research Centre:
|Faculty of Science, Engineering and Computing
Faculty of Science, Engineering and Computing > School of Life Sciences, Pharmacy and Chemistry
|Depositing User:
|Philip Keates
|Date Deposited:
|18 Feb 2020 11:25
|Last Modified:
|20 Feb 2020 08:23
Actions (Repository Editors)
|Item Control Page


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I don't know about panic buying in supermarkets but there is a definite sense of panic pub and pint purchasing amongst beer bloggers. A potential two month ban on new boozers is looking increasingly likely so any windows for a pint in a 'new pub' have to be grabbed. Forget about queueing at Tesco for… Continue reading Great Inner City Pubs: #1 The Falstaff
Tag: Derby CAMRA
The Worm Has Finally Turned
In times of national emergency then only The Two Ronnies can possibly rescue us. You might think I am referring to the coronavirus but no, it is The Worm That Turned from their 1980 series. Bizarrely, it was set in a futuristic world (2012!!!) where men and women had a job role reversal and Diana… Continue reading The Worm Has Finally Turned
Self Isolation In Marston Montgomery
With all the news surrounding coronavirus and self-isolation then I thought it is about time to visit an 'isolated village.' In fact, I even visited the new Lidl at Chellaston this week as I thought I should buy some 'emergency beer' just in case lockdown means I can't leave the crib for the next fortnight.… Continue reading Self Isolation In Marston Montgomery
Lively Sunday At The Stenson Fields
To be fair to Mudgie he is an absolute font of knowledge. I've probably learnt more about the history of beer on his blog than any other and he loves a good debate. He's also partial to a proper estate boozer and when I blogged about The Wilsthorpe Tavern recently he was quick on the… Continue reading Lively Sunday At The Stenson Fields
Never Mind The B&PF – Here's The Hilton Brook!
With all the excitement of attending my first Beer &Pubs Forum Big Day Out, albeit for one pub only, it is clear to me I have some work to do on the blogging front. These boys were Premier League as, after a full day on it in Burton,I joined them in The Roebuck (post to… Continue reading Never Mind The B&PF – Here's The Hilton Brook!
Long Term Survivor In Long Eaton
Having visited some stonking pubs on my recent jaunt to the Derbyshire Dales then I thought it was time to get back to the bread and butter of estate boozers. The most endangered of all pub species, they are often maligned, often neglected and often frowned upon by the chattering classes. In some instances these… Continue reading Long Term Survivor In Long Eaton
Zig Zag To The Peaks: Part 3 – Parking The Bus
The final leg of our Zig Zag to the Peaks saw us in Belper Bus Station before taking in the 6.1 to Derby Bus station and then the V3 back to Repton. This gives me another excuse to show this map and I wasn't going to mention the Zig Zag ticket again but (a) I… Continue reading Zig Zag To The Peaks: Part 3 – Parking The Bus


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text: ×Close Timeout Warning Your session is about to time out, do you want to continue your session? 60s left. Cancel Resume Session Art Along the Rio Grande Art Fair - Artist Interest Form First Name * Last Name * Company Name Email * Phone * Address * City * State/Province * Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming American Samoa Federated States of Micronesia Guam Marshall Islands Northern Mariana Islands Palau Puerto Rico U.S. Minor Outlying Islands Virgin Islands Armed Forces Americas Armed Forces Europe, the Middle East, an Armed Forces Pacific Alberta British Columbia Manitoba New Brunswick Newfoundland and Labrador Nova Scotia Northwest Territories Nunavat Territory Ontario Prince Edward Island Quebec Saskatchewan Yukon Territory Zip * I am interested in learning more about vending at the Following Event * April 25, 2020 - Art Along the Rio Grande Art Fair I would like to receive emails from the Friends of Valle de Oro National Wildlife Refuge about their programs and opportunities. * Yes No Powered by NeonCRM NEWSLETTER Subscribe to the Newsletter Receive updates and news right to your inbox!


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Spreadsheet Details
TopicGoogle spreadsheet dashboard examples.
AuthorSophia Swinburne
PostedFri, Jan 03rd 2020 20:03 PM
Project managers need to be in a position to ascertain the progress of their work. They need a tracking spreadsheet template for this task. A free spreadsheet template shows the various jobs to be undertaken and when they are expected to be completed. Overall, because of its function, this remains an important tool for planning purposes.
Google has a template for storing user information. They use the Google spreadsheet template to store details of contact numbers and other information. You can create the Google plan template by using Microsoft Excel. You can also download a template from the internet and customize it accordingly. It is an essential document.


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- We have spent a lot of time and effort in setting up this site. Please respect the content on this site and understand that it is for your personal use only. If you would like to use anything from this site, please contact us first. All contents of this website are Copyright © The Felting and Fiber Studio. All rights reserved.
Category Archives: Felt bags
Terry Berries Felted Bag Online Class
Registration for Teri Berry's Felted Bags online class is now open! This is a great course and was well received, so it's exciting it's being run again. There are limited spaces available so if you want to register, click on … Continue reading
A show and Picture Progress
I had a show on the weekend. It was quite good. We put a big push on advertising on Facebook and Instagram and it looks like it paid off. There were more customers this year. It's nice that everyone's efforts … Continue reading
Small Felt Pouches
First I wanted to let people know the discount code for lables is now up, it is at the bottom of the post. sew-on-labels I am almost finished the sewing of the small felt pouches. I still have to add … Continue reading
Posted in Design, embroidery, Felt bags, Stitching, Uncategorized, Wet Felting Tagged Felt bags, felt pouches, hand stitching on felt 12 Comments
Next Steps Putting Together the Bags.
Last time I showed you the parts of the bags ready to be put together. https://feltingandfiberstudio.com/2018/06/04/making-some-more-little-bags/ Now I will show you how I do it. First I wet one side. I use the resist to press the wool down and … Continue reading
Posted in Design, Felt bags, Nuno Felting, resists, Uncategorized, Wet Felting Tagged felted bags, nuno felt, nunofelt, self lining bags 13 Comments
Making Some More Little Bags
I haven't had much time to felt and today I finally got some time to start some new little bags. The last time I made little bags I forgot to add the spikes that end up as the closures so … Continue reading
Posted in Design, Felt bags, Nuno Felting, resists, Uncategorized, Wet Felting Tagged Felt bags, felted bag, nunofelt, self lining bags 13 Comments
A Sweater Story…..Can You Help?
At the start of February last year I posted that I had had a go at felting a sweater with designs on turning it into a bag. I had purchased it in a charity shop for the princely sum of £1. It … Continue reading
Posted in Community, Felt bags, Guest Writer Tagged fulled sweaters, recycled sweater 25 Comments
A Couple of Felted Pouches
This week I decided to make a new pouch for my business cards. The one I am using now is getting a little ratty looking from being in my purse for several years. I didn't take any in progress photos. … Continue reading
Posted in Design, Felt bags, Nuno Felting, Uncategorized, Wet Felting Tagged bisiness card holder, felt pouch, nunofelt 14 Comments


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BACKGROUND: Rice ratooning has traditionally been an important component of the rice cropping system in China. However, compared with the rice of the first harvest, few studies on factors effecting ratoon rice yield have been conducted. Because ratoon rice is a one-season rice cultivated using axillary buds that germinate on rice stakes and generate panicles after the first crop's harvest, its production is mainly affected by the growth of axillary buds. The objectives of this study were to evaluate the sprouting mechanism of axillary buds to improve the ratoon rice yield. RESULTS: First, we observed the differentiation and growth dynamics of axillary buds at different nodes of Shanyou 63, and found that they differentiated from bottom to top before the heading of the mother stem, and that they developed very slowly. After heading they differentiated from top to bottom, and the ones on the top, especially the top 2nd node, developed much faster than those at the other nodes. The average length and dry weight of the axillary buds were significantly greater than those at other nodes by the yellow ripe stage, and they differentiated into pistils and stamens by 6 d after the yellow ripe stage. The morphology of vegetative organs from regenerated tillers of Shanyou 63 also suggested the superior growth of the upper buds, which was regulated by hormones, in ratoon rice. Furthermore, a comprehensive proteome map of the rice axillary buds at the top 2nd node before and after the yellow ripe stage was established, and some proteins involved in steroid biosynthesis were significantly increased. Of these, four took part in brassinosteroid (BR) biosynthesis. Thus, BR signaling may play a role in the germination of axillary buds of ratoon rice. CONCLUSIONS: The data provide insights into the molecular mechanisms underlying BR signaling, and may allow researchers to explore further the biological functions of endogenous BRs in the germination of axillary buds of ratoon rice.
This current study retrospectively analyzed the clinical characteristics of 69 adult patients with acquired pure red cell aplasia (PRCA) including 40 elderly and 29 non-elderly patients from September 2009 to June 2019. The remission induction therapy regimens included cyclosporine A (CsA), corticosteroids (CS), or other immunosuppressive agents. The overall response rate was 55% (22/40) in the elderly group compared with 75.9% (22/29) in non-elderly patients (P = 0.075). In elderly patients, the best remission was achieved in the group treated with CsA than those treated with CS or other immunosuppressive agents (83.3% vs 26.7% vs 42.9%%, P = 0.004). However, outcomes of remission were similar among different treatment groups (P = 0.458) in non-elderly patients. CS induced a higher response rate in the non-elderly than that in the elderly (88.9% vs 26.7%, P = 0.009). By univariate and multivariate analysis, the clinical efficacy of elderly patients with acquired PRCA was closely associated with an induction regimen of CsA (P = 0.009; P = 0.017). In conclusion, CsA might produce higher response rate than CS and other drugs in elderly patients with acquired PRCA.
AssuntosCiclosporina/administração & dosagem , Imunossupressão , Aplasia Pura de Série Vermelha/tratamento farmacológico , Indução de Remissão , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Aplasia Pura de Série Vermelha/imunologia , Aplasia Pura de Série Vermelha/patologia
Trichomes are specialized epidermal cells that play crucial roles in resisting environmental stress and enhancing plant development. In Arabidopsis thaliana, the main genes controlling trichome formation have been consecutively identified. However, few genes like this were reported in rice. In this study, we identified the hairy phenotype of indica variety 75-1-127. This was used to construct a segregation population with a cross of hairless variety Minghui63 (MH63) to fine map the trichome formation genes. Genetic analysis indicated that hairy phenotype was controlled by a pair of dominant genes on chromosome 6, which was designated as GLABRA6 (OsGL6). OsGL6 was an allele of HL6 gene whose sequences containing rich variations in genomes. Compared to wild type, the overexpressing transgenic lines revealed that OsGL6 promoted trichome initiation. We found that OsGL6 interacted with serine/threonine protein kinase OSK3 (OSK3) or COP9 signalosome complex subunit 5a (CSN5) in yeast. These results provide potential information for understanding the molecular mechanism of trichome formation in rice.
BACKGROUND: Histoplasmosis is one of the invasive fungal infections and presents with symptoms mainly in the lungs. Disseminated histoplasmosis (DH) is rare and its lesions in the gastrointestinal tract are even uncommon. The concomitant involvement of the upper and lower gastrointestinal tract has never been described in the immunocompetent individuals. CASE PRESENTATION: A 44-year-old immunocompetent Chinese man presented with fever, hepatosplenomegaly, fungal esophagitis and protuberant lesions with central depression and erosion along the mucous membrane of the colon. The patient was diagnosed as disseminated histoplasmosis by gastrointestinal endoscopy. CONCLUSIONS: Histoplasmosis should be taken caution in patients with fever and hepatosplenomegaly. Actions should be taken to avoid its disseminated infection associated high mortality.
AssuntosHistoplasma/isolamento & purificação , Histoplasmose/diagnóstico , Adulto , Colo/diagnóstico por imagem , Colo/patologia , Endoscopia Gastrointestinal , Histoplasma/classificação , Histoplasma/genética , Histoplasmose/diagnóstico por imagem , Histoplasmose/imunologia , Histoplasmose/microbiologia , Humanos , Hospedeiro Imunocomprometido , Masculino
We demonstrate a novel, simple and convenient demulsification-based method called demulsification-induced fast solidification (DIFS) to fabricate polymer films. Two dimensional films, three dimensional films, and free-standing polyvinyl acetate and polyurethane acrylate films were fabricated via electrochemical deposition using the DIFS method.
Hybrid rice breeding for exploiting hybrid vigor, heterosis, has greatly increased grain yield. However, the heterosis-related genes associated with rice grain production remain largely unknown, partly because comprehensive mapping of heterosis-related traits is still labor-intensive and time-consuming. Here, we present a quantitative trait locus (QTL) mapping method, GradedPool-Seq, for rapidly mapping QTLs by whole-genome sequencing of graded-pool samples from F2 progeny via bulked-segregant analysis. We implement this method and map-based cloning to dissect the heterotic QTL GW3p6 from the female line. We then generate the near isogenic line NIL-FH676::GW3p6 by introgressing the GW3p6 allele from the female line Guangzhan63-4S into the male inbred line Fuhui676. The NIL-FH676::GW3p6 exhibits grain yield highly increased compared to Fuhui676. This study demonstrates that it may be possible to achieve a high level of grain production in inbred rice lines without the need to construct hybrids.
AssuntosMapeamento Cromossômico/métodos , Grão Comestível/genética , Vigor Híbrido/genética , Oryza/genética , Melhoramento Vegetal/métodos , Cromossomos de Plantas/genética , Locos de Características Quantitativas/genética
We report the first imported case in China of human African trypanosomiasis (HAT), caused by Trypanosoma brucei gambiense, in a sailor returning from Gabon in 2014. The diagnosis was delayed and relapse led to death, despite treatment with eflornithine, as recommended by the World Health Organization for late-stage HAT. This case shows that early diagnosis of HAT and close follow-up with proper retreatment are critical.
AssuntosDoenças Transmissíveis Importadas/parasitologia , Trypanosoma brucei gambiense , Tripanossomíase Africana/parasitologia , Animais , China , Doenças Transmissíveis Importadas/diagnóstico , Doenças Transmissíveis Importadas/tratamento farmacológico , Eflornitina/uso terapêutico , Evolução Fatal , Gabão , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva , Tripanossomicidas/uso terapêutico , Tripanossomíase Africana/diagnóstico , Tripanossomíase Africana/tratamento farmacológico
Dynamic combinatorial library (DCL) has emerged as an efficient tool for ligand discovery and become an important discovery modality in biomedical research. However, the applications of DCLs have been significantly hampered by low library diversity and limited analytical methods capable of processing large libraries. Here, we report a strategy that has addressed this limitation and can select cooperatively binding small-molecule pairs from large-scale dynamic libraries. Our approach is based on DNA-mediated dynamic hybridization, DNA-encoding, and a photo-cross-linking-based decoding scheme. To demonstrate the generality and performance of this approach, a 10â¯000-member DNA-encoded dynamic library has been prepared and selected against six protein targets. Specific binders have been identified for each target, and we have validated the biological activities of selected ligands for the targets that are implicated in important cellular functions including protein deacetylation and sumoylation. Notably, a series of novel and selective sirtuin-3 inhibitors have been developed. Our study has circumvented a major obstacle in DCL and may provide a broadly applicable method for ligand discovery against biological targets.
AssuntosDNA/química , Descoberta de Drogas , Bibliotecas de Moléculas Pequenas/química , Ligantes , Conformação Molecular
OBJECTIVE: To analyze the clinical and laboratory features of acute myeloid leukemia (AML) with cuplike nuclei morphology. METHODS: One hundred and seventy patients diagnosed with AML (M1andM2) between December 2009 and December 2016 were included in the study. Bone marrow smears were prepared for morphologic alanalysis, the immunophenotype was analyzed by flow cytometry and the RHG-banding was for conventional cytogenetic assay (CCA) ,gene mutation was detected by sequencing. RESULTS: Among the 170 AMLpatients, 67 were diagnosed as M1 and 103 patients was diagnosed as M2, 43 patients(25.3%) defined as cuplike nuclei-positive, among them 38patients (88.4%) were M1 while only 5 patients (11.6%) were with M2(P<0.01). No significant value about sex(P> 0.05) between cuplike nuclei-positive and -negative group, while older patients were found in cuplike nuclei-positive group (P<0.05). Higher peroxydas (POX) ratio (P<0.05) and integration (P<0.05) were found in cuplike nuclei- positive group. Furthermore, the patients with cuplike nuclei-positive lack the expressions of CD34 (P<0.01) and HLA-DR(P<0.01) while no other immunophenotype markers were found. Among the 152 patients (89.4%) for genetic analysis ,83.8% karyotype of the cuplike nuclei-positive group were normal while only 54.8 of negative group was normal by CCA. Molecular biology analysis showed that the patients in cuplike nuclei-positive group have significantly highe rNMP1 (P<0.01) and FLT3(P<0.01) mutations as compared with the negative group. Furthermore, the relationship of the ratio o fcuplike nuclei and the type of gene mutations were investigated, and no significant associations were found. However, it was found that the patients with FLT3 mutation displayed more biological nuclear invagination than the patients with NPM1 mutations (P<0/01). CONCLUSION: AML patients with positive cuplike nuclei have characteristic morphological changes, typical immunophenotype with HLA-DR- and CD34-, normal karyotype accompanied by NPM1 and FLT3 mutations.
AssuntosLeucemia Mieloide Aguda , Núcleo Celular , Humanos , Mutação , Proteínas Nucleares , Prognóstico , Tirosina Quinase 3 Semelhante a fms
AIMS: We investigated the effects of chemical stimulation of cerebellum fastigial nucleus (FN) on the chronic visceral hypersensitivity (CVH) and its possible mechanism in rats. MAIN METHODS: We stimulated the FN by microinjecting glutamate into the FN, in order to explore whether the cerebellum fastigial nucleus played a role on CVH in rat. The model of CVH was established by colorectal distension (CRD) in neonatal rats. Abdominal withdrawal reflex (AWR) scores, pain threshold, and amplitude of electromyography (EMG) were used to assess the hyperalgesia. KEY FINDINGS: We showed that microinjection of l-glutamate (Glu) into the FN markedly attenuated hyperalgesia. The protective effect of FN was prevented by pretreatment with the glutamate decarboxylase inhibitor, 3-mercaptopropionic acid (3-MPA) into the FN or GABAA receptor antagonist, bicuculline (Bic) into the LHA (lateral hypothalamic area). The expressions of protein Bax, caspase-3 were decreased, but the expression of protein Bcl-2 was increased after chemical stimulation of FN. These results indicated that the FN participated in regulation of CVH, and was a specific area in the CNS for exerting protective effects on the CVH. In addition, LHA and GABA receptor may be involved in this process. SIGNIFICANCE: Our findings might provide a new and improved understanding of the FN function, and might show an effective treatment strategy for the chronic visceral hypersensitivity.
AssuntosCerebelo/efeitos dos fármacos , Dor Crônica/tratamento farmacológico , Modelos Animais de Doenças , Ácido Glutâmico/farmacologia , Fármacos Neuroprotetores/farmacologia , Dor Visceral/tratamento farmacológico , Animais , Animais Recém-Nascidos , Comportamento Animal/efeitos dos fármacos , Dor Crônica/patologia , Feminino , Ácido Glutâmico/administração & dosagem , Injeções , Ratos , Ratos Sprague-Dawley , Dor Visceral/patologia
Hybrid rice has been successfully used for commercial rice production for 40 years in China. Shanyou 63, a mega rice hybrid, derived from the parents Zhenshan 97A and Minghui 63, was a milestone for China's hybrid rice development and production because of its high yield and wide adaptability. It was planted in 16 provinces of the country on 17% of the national hybrid rice area annually during the 29 years from 1984 to 2012. The hybrid and its parents have also been widely used for basic and agronomic studies related to rice heterosis, stress tolerance, molecular markers and genomics. We review the development of the hybrid and its parents and their major characteristics for the purpose of learning from the history and guiding future hybrid rice development. The history and development experience show that a successful hybrid rice variety should have multiple traits, including high yield, wide adaptability, resistances to major diseases, and high rice quality that meets the demands of consumers. From the breeding aspect, hybrid rice provides the advantage of combining elite traits or genes from different types of parents, such as those from subspecies of indica and japonica, into a single variety. Farmers prefer not only a variety with high yield potential, but also stable yields and local adaptability.
To assess response to cyclosporine A, and/or corticosteroids, and possible factors influencing the response in adult patients with acquired pure red cell aplasia (PRCA). Clinical data from 42 cases were retrospectively analyzed. These patients received cyclosporine A (CsA), and/or corticosteroids (CS), or other immunosuppressive agents on becoming refractory and relapse. Thirty-nine patients were evaluated. Remission induction therapy included CsA (n = 16), CS (n = 13), CsA in combination with CS (n = 6), or other immunosuppressive agents (n = 4). Initial response rates were 75.0, 46.2, 66.7 and 75.0%, respectively (P = 0.456). Cumulative response rates in patients who received CsA, CS, CsA in combination with CS, or other immunosuppressive agents were 69.6% (16/23), 50.0% (7/14), 71.4% (5/7), 42.9% (6/14), respectively (P = 0.376). Cumulative rates of CR were 26.1% (6/23), 28.6% (4/14), 57.1% (4/7), 14.3% (2/14), respectively (P = 0.284). In 27 refractory and relapsed PRCA patients, 11 of 17 patients (64.7%) achieved remission by CsA and/or CS regimen, while three of ten patients (30.0%) responded to other immunosuppressive agents (P = 0.120). CsA and/or CS were effective in treating PRCA. For patients with relapse or refractory PRCA, there were no satisfactory treatments if CsA and/or CS failed or were not administered.
AssuntosCiclosporina/administração & dosagem , Glucocorticoides/administração & dosagem , Imunossupressores/administração & dosagem , Prednisona/administração & dosagem , Adulto , Idoso , Idoso de 80 Anos ou mais , Quimioterapia Combinada , Feminino , Seguimentos , Humanos , Quimioterapia de Indução , Masculino , Pessoa de Meia-Idade , Recidiva , Aplasia Pura de Série Vermelha/tratamento farmacológico , Estudos Retrospectivos , Terapia de Salvação , Falha de Tratamento , Resultado do Tratamento
Peroxiredoxins (Prxs) which are thiol-based peroxidases have been implicated in the toxic reduction and intracellular concentration regulation of hydrogen peroxide. In Arabidopsis thaliana At2-CysPrxB (At5g06290) has been demonstrated to be essential in maintaining the water-water cycle for proper H2O2 scavenging. Although the mechanisms of 2-Cys Prxs have been extensively studied in Arabidopsis thaliana, the function of 2-Cys Prxs in rice is unclear. In this study, a rice homologue gene of At2-CysPrxB, OsPRX2 was investigated aiming to characterize the effect of 2-Cys Prxs on the K+-deficiency tolerance in rice. We found that OsPRX2 was localized in the chloroplast. Overexpressed OsPRX2 causes the stomatal closing and K+-deficiency tolerance increasing, while knockout of OsPRX2 lead to serious defects in leaves phenotype and the stomatal opening under the K+-deficiency tolerance. Detection of K+ accumulation, antioxidant activity of transgenic plants under the starvation of potassium, further confirmed that OsPRX2 is a potential target for engineering plants with improved potassium deficiency tolerance.
AssuntosOryza/metabolismo , Peroxirredoxinas/metabolismo , Proteínas de Plantas/metabolismo , Estômatos de Plantas/metabolismo , Potássio/metabolismo , Clonagem Molecular , Regulação da Expressão Gênica de Plantas , Oryza/anatomia & histologia , Oryza/genética , Oryza/ultraestrutura , Peroxirredoxinas/análise , Peroxirredoxinas/genética , Filogenia , Proteínas de Plantas/análise , Proteínas de Plantas/genética , Estômatos de Plantas/anatomia & histologia , Estômatos de Plantas/genética , Estômatos de Plantas/ultraestrutura , Plantas Geneticamente Modificadas/anatomia & histologia , Plantas Geneticamente Modificadas/genética , Plantas Geneticamente Modificadas/metabolismo , Plantas Geneticamente Modificadas/ultraestrutura , Regulação para Cima
OBJECTIVE: To investigate the distribution of T helper (Th9) cells and its relationship with clinical characteristics of patients with acute myeloid leukemia (AML), and to analyze the activating levels of different transcriptional factors in Th9 cells. METHODS: The peripheral blood specimens of 102 AML patients and 83 healthy persons as controls were collected, then the T cells of peripheral blood in AML patients and controls were isolated by using CD3 magnetic beads, the mRNA expression of IL-9 was detected by real-time quantitative PCR, the Th9(CD4+IL-9+) cell levels in diffrent stages and activating level of Th9 coexpression with IL-9 were detected by flow cytometry. RESULTS: The mRNA expression of IL-9 in peripheral blood of AML M2 and M3 patients was significantly higher than that in control groups (P<0.01), at same time the CD4+IL-9+ cell rate was significantly higher than that in control group also(P<0.01). The results of dynamically monitoring the distribution of Th9 cells in AML-M2 and M3 patients showed that the Th9 cell rate and the mRNA expression of IL-9 in newly diagnosed M2 and M3, and relapsed M2 groups were significantly higher than those of M2 and M3 in remission (P<0.01); the detection results of IL-9- co-expression with transcriptional factors (SMAD3+, IRF-1+ and IRF-4+) indicated that the percantage of Th9 pSMAD3+ cells in peripheral blood of newly diagnosed and relapsed M2 and M3 patients was significantly higher than that in M2 and M3 patients in remission (P<0.01); on the contrary, the percentage of Th9 IRF-1+ cells in peripheral blood of M2 and M3 patients in remission was significantly higher than that in newly diagnosed M2 and M3 patients (P<0.01). CONCLUSION: The distribution of T helper cells in peripheral blood of AML-M2 and M3 patients significantly increases, moreover, correlates with disease status. The prediction of Th9 cell functions should be performed in combination with it transcriptional factors which have inmportant significance for microenvironment of tumors in AML patients.
AssuntosLinfócitos T CD4-Positivos , Leucemia Mieloide Aguda/imunologia , Linfócitos T Auxiliares-Indutores , Estudos de Casos e Controles , Citometria de Fluxo , Humanos
Pituitary adenoma (PA) is a common type of benign tumor of the pituitary gland that is characterized by specific signs and symptoms, primarily associated with hypersecretion of pituitary glycoprotein hormones (thyroid-stimulating, growth and adrenocorticotrophic hormones, and prolactin). Surgery is the first-line treatment, although postoperative residual tissues/cells and subsequent recurrence remain notable complications. Gene therapy is an effective approach for treatment, as previous studies have demonstrated that the Notch signaling pathway participates in the pathogenesis of PA. The focus of the present study was on the associations between the expression of the Notch1 receptor and its ligands δ-like canonical Notch ligand (Dll) 1, Dll3 and Dll4 in patients with PA. Using reverse transcription-quantitative polymerase chain reaction and western blot analyses, to the best of our knowledge, this is the first study to provide a description of the differential expression of the Notch1 receptor and its ligands Dll1, Dll3, and Dll4 in various types of human PA at the mRNA and protein levels. The results of the present study demonstrated that Notch1 protein expression was positively correlated with Dll4 protein expression, but negatively correlated with Dll3 protein expression, indicating synergistic effects between the Notch1 receptor and Dll4 ligand. Furthermore, the Dll3 ligand may be an inhibitor of the Notch1 receptor, indicating an antagonistic association between Notch1 and the Dll3 ligand. These results have identified a potential target for the treatment of patients with PA.
Crop breeding aims to balance disease resistance with yield; however, single resistance (R) genes can lead to resistance breakdown, and R gene pyramiding may affect growth fitness. Here we report that the rice Pigm locus contains a cluster of genes encoding nucleotide-binding leucine-rich repeat (NLR) receptors that confer durable resistance to the fungus Magnaporthe oryzae without yield penalty. Among these NLR receptors, PigmR confers broad-spectrum resistance, whereas PigmS competitively attenuates PigmR homodimerization to suppress resistance. PigmS expression, and thus PigmR-mediated resistance, are subjected to tight epigenetic regulation. PigmS increases seed production to counteract the yield cost induced by PigmR Therefore, our study reveals a mechanism balancing high disease resistance and yield through epigenetic regulation of paired antagonistic NLR receptors, providing a tool to develop elite crop varieties.
AssuntosResistência à Doença/genética , Epigênese Genética , Regulação da Expressão Gênica de Plantas , Genes de Plantas , Magnaporthe , Proteínas NLR/genética , Oryza/microbiologia , Doenças das Plantas/microbiologia , Cruzamento , Produtos Agrícolas/genética , Produtos Agrícolas/microbiologia , Metilação de DNA , Loci Gênicos , Família Multigênica , Proteínas NLR/química , Oryza/genética , Doenças das Plantas/genética , Multimerização Proteica
Rotary ultrasonic machining (RUM) is a well-known and efficient method for manufacturing holes in brittle materials. RUM is characterized by improved material removal rates, reduced cutting forces and reduced edge chipping sizes at the hole exit. The aim of this study is to investigate the critical feed rate to guarantee the effectiveness of RUM. Experimental results on quartz glass and sapphire specimens show that when the feed rate exceeds a critical value, the cutting force increases abruptly, accompanied by a significant decrease of ultrasonic amplitude. An analytical model for the prediction of critical feed rates is presented, based on indentation fracture mechanic and the theory of impact of vibrating systems. This model establishes the theoretical relationships between the critical feed rate, idling resonant ultrasonic amplitude and spindle speed. The results predicted by the analytical model were in good agreement with the experimental results.
DNA-encoded chemical library (DEL) has emerged as a powerful and versatile tool for ligand discovery in chemical biology research and in drug discovery. Encoding and selection methods are two of the most important technological aspects of DEL that can dictate the performance and utilities of DELs. In this digest, we have summarized recent advances on the encoding and selection strategies of DEL and also discussed the latest developments on DNA-encoded dynamic library, a new frontier in DEL research.
AssuntosDNA/metabolismo , Bibliotecas de Moléculas Pequenas/metabolismo , Técnicas de Química Combinatória , DNA/química , Descoberta de Drogas , Ensaios de Triagem em Larga Escala , Ligantes , Hibridização de Ácido Nucleico , Bibliotecas de Moléculas Pequenas/química
Silicon carbide radiation detectors are attractive in the measurement of the total numbers of pulsed fast neutrons emitted from nuclear fusion and fission devices because of high neutron-gamma discrimination and good radiation resistance. A fast-neutron detection system was developed based on a large-area 4H-SiC Schottky diode detector and a 235U fission target. Excellent pulse-height spectra of fission fragments induced by mono-energy deuterium-tritium (D-T) fusion neutrons and continuous energy fission neutrons were obtained. The detector is proven to be a good candidate for pulsed fast neutron detection in a complex radiation field.
Prostate Cancer has become the second leading cause of male cancer-related incidence and mortality in United States. Hyperthermia (HT) is known to serve as a powerful tool in treatment of prostate cancer in clinical. The combination treatment with HT and cisplatin has a synergistic effect to inhibit prostate cancer progression and demonstrates better clinical effectiveness than HT or chemotherapy alone. But molecular mechanisms of this phenomenon have not been illuminated clearly. In this study, we used MTS assay to examine cell viabilities of PC-3, LNCaP, DU-145 and RM-1 cells after treated by HT and cisplatin. Then colony formation of PC-3 and DU-145 cells after treated with HT and cisplatin were photographed. To investigate whether the combination therapy would enhance apoptosis of PC-3 and DU-145 cells, we used Western blot analysis to detect expression level of proteins on apoptosis-regulated signaling pathway in PC-3 and DU-145 cells. Our results showed that the combination treatment decreased cell viabilities and colony formation of prostate cancer cells in a dose-dependent manner and this combination therapy enhanced apoptosis of PC-3 and DU-145 cells via activation of Caspase-3 and cleavage of PARP. We also found that the combination therapy could down-regulate the anti-apoptotic Bcl-2 and IAP family proteins. At last, the combination therapy activated AMPKα-JNK signaling pathway and inhibited Akt-mTOR-p70s6k signaling pathway to promote apoptosis of PC-3 and DU-145 cells. In conclusion, this study clearly elucidated how the combination therapy with HT and cisplatin promoted apoptosis of prostate cancer cells in synergy.


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TRO Marine Sensors aboard USS Anchorage
Pronghorn Technologies, LLC announced the ongoing collaboration and evaluation of its Total Residual Oxidant (TRO) Marine Sensors aboard the US Navy's USS Anchorage (LPD 23), one of the most…
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