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Now in your reconsideration request make sure you are honest and tell Google everything that the prior agency was up too. Be sure to include all Excel information of removed links and say you are going to make an ongoing effort to remove everything negative. It is common knowledge that Google may not accept your first reconsideration request, so it may take a few times.
Brian hello! First off I want to THANK YOU for this fantastic post. I can't emphasize that enough. I have this bookmarked and keep going through it to help boost our blog. I totally nerded out on this, especially the LSI keywords which made my day. I know, pathetic, right? But when so much changes in SEO all the time, these kinds of posts are so helpful. So thanks for this. So no question – just praise, hope that's ok 😁
There is no magic formula for content marketing success, despite what some would have you believe. For this reason, vary the length and format of your content to make it as appealing as possible to different kinds of readers. Intersperse shorter, news-based blog posts with long-form content as well as video, infographics and data-driven pieces for maximum impact.
To find the right people I downloaded a list of some of the most popular users within the community. To do this, I used Screaming Frog SEO Spider to gather a list of all the URLs on the website. I then exported this list into an Excel spreadsheet and filtered the URLs to only show those that were user profile pages. I could do this because all of the profile pages had /user/ within the URL.
Basically, what I'm talking about here is finding websites that have mentioned your brand name but they haven't actually linked to you. For example, someone may have mentioned my name in an article they wrote ("Matthew Barby did this…") but they didn't link to matthewbarby.com. By checking for websites like this you can find quick opportunities to get them to add a link.
So many great tips! There are a couple of things I've implemented recently to try and boost traffic. One is to make a pdf version of my post that people can download. It's a great way to build a list:) Another way is to make a podcast out of my post. I can then take a snippet of it and place it on my Facebook page as well as syndicate it. As far as video I've started to create a video with just a few key points from the post. The suggestion about going back to past articles is a tip I am definitely going to use especially since long-form content is so important. Thanks!
Another way to increase traffic to your website is to get listed in free online directories and review sites. For most of these sites, your profile will have a link to your website, so actively updating these listings and getting positive reviews is likely to result in more website traffic. In addition, many directories like Yelp have strong domain authority on Google. There's a chance that your business's free Yelp page could rank high for relevant searches.
Because your site likely has a really low score, you'll want to start targeting relevant keywords and phrases – but don't go for the big shit like "business ideas" because you'll never get anywhere. Instead, aim for long-tail keyword phrases, like "best side business ideas" – fun fact: that's a real example of a long-tail keyword I use for my blog.
Thanks for a this timely article. If I understand it correctly, are you saying that we would better be off looking at market data in our niche and make an article of that for influencers to share rather than actionable tips that the target clients would be interested in? Shouldn't there be a double strategy – articles for the influencers to share and articles for the users to enjoy?
Very useful article. I like how you've combines videos, images, graphs, text and an infographic all in one piece Ross, very cool. I also like the KOB analysis info. I think I met you a few years ago Ross at a search love in Boston, ever present there? Also, here is an article that lists some good data on conversion optimization: http://www.oakwebworks.com/what-influences-online-consumers-most.htm
Whatever industry you're in, chances are there are at least one or two major conventions and conferences that are relevant to your business. Attending these events is a good idea – speaking at them is even better. Even a halfway decent speaking engagement is an excellent way to establish yourself as a thought leader in your industry and gain significant exposure for your site.
First, I will show you a quick snapshot of the traffic uplift, which yielded an additional 400,000 unique visitors from organic search traffic on a monthly basis. Then I will explain to you the steps in which we took to get the client to this level. I have also tried to keep this quite general so everyone can adapt their own situation to this case study.
But some schema extensions are targeted at search engines. These code snippets tell Google which elements you would like to display next to your links in the search results. Of course, Google isn't obliged to follow your instructions, and they can totally ignore the schema you insert in your code. But often, Google honors the schema you insert in your pages.
Want the skinny on how you can drive traffic to your website? The following traffic-driving strategies are organic in nature. You won't have to pay a single dollar for traffic that falls under this bucket. But you will have to trade your time. And since time is more valuable than money, in that it can only be used once then it's gone forever, there's still a significant cost involved depending on your skill level.
You probably already have a budget for a lot of these activities, so you may just need to reallocate some of your spending. For instance, maybe you already have an in-house writer who handles your company's blog and social media. She has a basic understanding of SEO, but she's not looking at search data to shape the editorial calendar. You saw a spike in organic traffic a few years ago when you launched the blog, but now it seems to have reached a plateau. To make up for the slow growth there, you've been investing a lot more in Google Ads. The ads help with visibility, but they're not getting the conversions you want. You also want to create some professional looking videos, but the extent of your staff's experience is using their iPhones to capture their dogs' new tricks.
How can you get the context part right? It begins with planning topics that are a good fit for your customer personas and then aligning them with appropriate high and mid-volume keywords. As Content Marketing Institute discusses, be very careful not to "over" optimize – keyword stuffing or trying to rank for a keyword just because it has a lot of searches can backfire on you. Always keep that target audience in mind.
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If both page are closely related (lots of topical overlap), I would merge the unique content from the lower ranking article into the top ranking one, then 301 redirect the lower performing article into the top ranking one. This will make the canonical version more relevant, and give it an immediate authority boost. I would also fetch it right away, do some link building, and possibly a little paid promotion to seed some engagement. Update the time stamp.
I am too much late to commenting on this article. I want to read "How much get Organic traffic by SEO", found your your article on top & really very interesting. James Norquay, you did good research.I think Now days google block mostly SEO activities. Is this worthy for current marketing scnerio?If any other post to related strategy for increasing Organic traffic, you can reffer me.
Holy Engagement! This was an awesome post, full of great info… and then I realized that 3/4 of the actual page was comments… which is even better for shares, SEO and overall engagement. I was lucky enough to attend an event where Neil Patel was giving some great blogging training and a lot of what you covered was there. https://www.thatbloggingthing.com/69-blogging-secrets-i-stole-from-neil-patel/ The simple fact that you comment back is awesome.
Pinterest Promoted Pins have been the number one source of traffic to my new website, and they're far cheaper than Facebook Ads for my audience. A small $5-10 per day budget has resulted in 1,127 clicks to my website in the last 30 days. The best part? Even once I stop running the promotions, my pins will still show where people have pinned them, so they'll continue to drive traffic to my website
In addition to maintaining a robust social media presence on your chosen platforms, joining social media groups can help you get your brand in front of new audiences and show your industry expertise. Find and join groups related to your industry and volunteer to answer questions or provide insight to create relationships, build brand awareness, and generate website traffic.
If your social media profiles contain a link to your website, then you've turned your engagement into another channel for website traffic. Just be sure to engage moderately and in a sincere way, and avoid including links to your website in your comments—lest you appear spammy and hurt your online and business reputation. Increased traffic should not be the goal of your engagement, but rather a secondary result.
Okay, so that gives you a sense of the general areas that your traffic will come from and how you should go about tracking your traffic. Remember, if you're not tracking the traffic that's coming to your website, you're wasting your time marketing online. When you drive traffic to any site, blog or wherever, you need to understand where it's coming from so that you can scale your efforts.
What this means is that if someone visits a website and is logged into their Google account, the site owner cannot see the search keywords they used to get there. This has resulted in a great deal of organic traffic being incorrectly marked as direct. The same thing happened to Apple iOS 6 users carrying out Google searches through the Safari browser, after the operating system's privacy settings were changed, as Search Engine Land reports.
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To get started with guest posting, you'll need to reach out to blogs that appeal to the type of audience you'd like to target. Instead of just sending along a full article, provide the blog's editors with a summary of your intended topic, and give them a chance to approve it first. This improves your chances of getting published successfully (and saves you from wasting valuable time).


text: Lukas Foss in conversation with Studs Terkel BROADCAST: Feb. 23, 1987 | DURATION: 00:49:21 Digital audio not yet public. Details Broadcast Date Feb. 23, 1987 Digital Format WAV Duration 49 minutes, 21 seconds Language English Ownership The Chicago History Museum Topics Music Music - Classical Music & Opera People Musicians Related Programs Franz Schulze talks with Studs Terkel Part 1 Apr. 16, 1962 Ron Modell discusses the Jazz band at Northwestern University, Chicago Jul. 3, 1980 Rolf Liebermann discusses the Hamburg State Opera and describes their operation and performances 1967 Odetta talks about her music career and sings to Studs Terkel 1956 Ralph Ellison American novelist and literary critic discusses his life and writing 1970 Teresa Stich-Randall talks with Studs Terkel Dec. 1, 1964

subset: commoncrawl


text:
To celebrate the launch of The Lost Heir 3: Demon War, we're also announcing that two of Mike's other games in our Hosted Games program, Life of a Wizard and Life of a Mobster are out now on Steam! Write an archmage's autobiography in this 80-year 130,000-word interactive fiction. Play good or evil, man or woman, as you bring peace to the kingdom or take over the world with your sorcery. Brew potions, raise the dead, summon mythical beasts, control men's minds, and blast away your enemies. Life of a Wizard is an epic interactive novel by Mike Walter where
If you would like to host your site, these best web hosting for a personal website services are your go to choices. Nowadays, more and more people are building websites both for personal and business reasons. But even a website that was made only for personal use can mysteriously become popular, and you later turn it into a money making machine. Always plan long-term when it comes to putting together a page for your online project.
You can also host your website on WordPress.com, but that's different from the kind of hosting mentioned above. WordPress.com uses the same code from WordPress.org, but it hides the server code and handles the hosting for you. In that sense, it resembles entries in our online site builder roundup. It's a simpler but less flexible and customizable way to approach WordPress hosting. It's definitely easier, but if you want to tinker and adjust and optimize every aspect of your site, it might not be for you.
The company also offers higher-end Windows and Linux servers, available with Plesk and cPanel respectively. We were very intrigued to see that the company offers low-end Atom-based dedicated servers as well as the more traditional Xeon-based machines. One great resource for those doing some basic experimentation, or site development, is that it has a free, three-month trial for one of its lightly equipped Atom servers.
You could think of the sites that share your server as your roommates; there's really not that much separating you from them. Sure, you can close the bedroom door, but they can still cause nightmares for you in the kitchen and the bathroom. In web hosting terms, all the sites share a single server's resources, so huge traffic spike on Site A may impact the neighboring sites' performances. It's even possible that another site could take down the shared server altogether, if it crashed hard enough.
Cloudways is, needless to say, a web hosting service which is focused on one thing only, cloud web hosting, hence the name. They offer a fully managed cloud hosting of which all plans have one fantastic feature: pay as you go. In other words, you only pay for the resources you need and nothing else. This makes it very user-friendly, for everyone to benefit from. Being the type of a hosting provider which focuses only on managed cloud hosting platform, it makes them one of the best at what they do. If you are looking for something else, Cloudways is not the host to go with.
So everything is perfect the games the set up the menus all of it the only one thing that gets me really really to the point of raging quitting deleting the thing and then re-downloading the app the next day is the fact that once you choose an option something bad happens and the other is checkpoint in the game however there are no buttons that say reload last checkpoint and that really really bothers me because then I have to restart even if I'm in the middle of the game and if I want a perfect game which I do sorry for you now I would love to have a reload last check. Maybe it's because there's something wrong with the coding or something that you can't get it to happen like that but I would love to have something like that.
For more than a decade, Jeffrey L. Wilson has penned gadget- and video game-related nerd-copy for a variety of publications, including 1UP, 2D-X, The Cask, Laptop, LifeStyler, Parenting, Sync, Wise Bread, and WWE. He now brings his knowledge and skillset to PCMag as Senior Analyst. When he isn't staring at a monitor (or two) and churning out web hosting, music, utilities, and video game copy, Jeffrey makes comic books, mentors, practices bass and Jeet Kune Do, and appears on the odd podcasts or convention panel. He also collects vinyl and greatly enjoys a craft brew. You can a find Jeffrey online at jeffreylwilson.net, or send him a tweet at @jeffreylwilson
Many hosting plans offer a free domain and at least one free email account with a matching email address ([email protected]). Bluehost offers the best deal; its $2.95/month Basic Shared hosting plan offers a free domain and five free matching email accounts or addresses. Other hosting providers that also offer a free email address to match a free domain in their plans include GoDaddy and InMotion, although for a higher monthly fee than Bluehost.
This is Part 2 of a 3-part series of posts about First Year Demons. In the first part, I talked about games in education, and why ChoiceScript games can be a good method for teaching about culture. In this part, I'll talk about how we decided on the setting and story for First Year Demons. Choosing a Culture and Story The people who would be playing these games to learn the information contained in them would primarily be university students in the US and Canada. Therefore, we took North American culture as our "home" culture. We decided that the contrast
From free drag and drop builder, free domain registration and even free marketing tools and emails, that is all that comes with iPage's special intro offer. iPage also offers a 30-day money back guarantee for those who would like to try something else. Chances are, that will not happen and you will stay with iPage forever. Or at least for the starting part of your online journey. It all comes down to the fact what are your long-term plans you have for your website.
Welcome to the CNET 2020 directory of web hosting services. In this directory, we'll look at a few of the best web hosting providers like Bluehost, A2Hosting, Hostinger, DreamHost, HostGator, InMotion Hosting and more. In this evaluation of the best web hosting providers, we're featuring commercial web hosting companies that offer WordPress, VPS, shared hosting and many more web hosting services, along with a variety of annual and monthly plans.
This is Part 3 of a 3-part series of posts about the Hosted Game First Year Demons. In the first part, I talked about games in education, and why ChoiceScript games can be a good method for teaching about culture. In the second part, I talked about our process for developing the setting and story for First Year Demons. In this part, I'll talk about the differences in design and story between the two versions of the game. Educational Game vs. Story Game An educational game – at least, this particular variety of educational game – is written with the
Squarespace is a website builder and hosting provider that offers a free domain with hosting plans. Its $12/month Personal plan comes with unlimited storage and a drag-and-drop builder. Its $18/month Business plan further offers email, analytics, and payment processing with a 3% transaction fee. Its industry-specific templates make it best for time-strapped companies that need to choose a template quickly, and then add information for a professional design.
how to start a bloghow to make a websitehow to register a domainhow to start an online storethe cost of building a sitewordpress giveaway pluginhow to grow your email listWP coming soon pluginsbest website buildersbest blogging platformsbest ecommerce pluginsbest lead-gen pluginsbest membership pluginsbest contact form pluginsbest email marketing toolsbusiness phone servicesbest page builder pluginsbest live chat softwarebest backup pluginsbest lms pluginsbest security pluginsbest CRM softwarebest SMTP serviceseverything
All of this infrastructure has been built out to support the a wide range of hosting services. The family-owned company gains points for understanding the importance of transaction security by offering free AutoSSL and Let's Encrypt SSL encryption for its plans. While the company offers sophisticated services for technically strong clients, it also has a Weebly web builder option to get you up and running quickly.
Click the box next to any add-ons you would like. These include 99 cents-per-month domain privacy, which hides your contact information on domain listing sites; SiteLock for $1.99 per month, which "locks" a domain so it can't be transferred without signing in; Codeguard Basic for $2.99 per month, which offers security features like one-click restores; and Bluehost's $1.99 per month SEO Tools, (which include features like website submissions to search engines).
Spam is a widespread phenomenon on the internet. Unwanted emails are not only a nuisance, they can also contain malicious phishing links or Trojans disguised as attachments. Our efficient IONOS email spam filter protects you against unwanted messages. In the settings of your email account you can activate the free IONOS email spam blocker. This filters out a large portion of suspicious content and unsafe contacts. If you are still receiving regular spam messages, you can make further adjustments to the web mail settings. For example, in the email spam filter settings, you can add certain email addresses and contacts on an email spam blacklist. Mails from contacts in this blacklist are automatically deleted, and you can remove a contact from the blacklist at any given time.
Dedicated hosting is no longer a thing today. There are very little companies that offers that. Most of the serious businesses are hosted on Amazon AWS, Azure or Google Cloud because these services offers better reliability, scalability and tools for the job. Huge websites like Instagram, Reddit, Twitter are hosted within their infrastructure. If you are looking for a serious processing power these services are must have. Or even VPS providers such as Linode and Digital Ocean are great options if you are looking for flexibility.
Cloudways is, needless to say, a web hosting service which is focused on one thing only, cloud web hosting, hence the name. They offer a fully managed cloud hosting of which all plans have one fantastic feature: pay as you go. In other words, you only pay for the resources you need and nothing else. This makes it very user-friendly, for everyone to benefit from. Being the type of a hosting provider which focuses only on managed cloud hosting platform, it makes them one of the best at what they do. If you are looking for something else, Cloudways is not the host to go with.
Your page, which you always dreamt about launching, gets realized with DreamHost easily. It is a superb web hosting for a personal website with the cutting edge technology. Depending on your needs, there are two hostings which you can go with, WordPress or shared. Both are fully loaded with excellent features for your website to shine in the online space. Since DreamHost uses SSD servers, your website's performance will be way faster compared to HDD servers. To be sure your website will be live at all times, they automatically scale up bandwidth when needed. On top of that, DreamHost is putting a lot of time and effort into making their services the most secure out there.
Many web hosting services offer so-called unlimited or unmetered service for whatever amount of bandwidth, disk storage and sites you use. It's important to understand that most terms of service actually do limit the definition of "unlimited" to what's considered reasonable use. The bottom line is simple: if you're building a pretty basic website, unlimited means you don't need to worry. But if you're trying to do something excessive (or illegal, immoral or fattening), the fine print in the terms of service will trigger, and you'll either be asked to spend more or go elsewhere.
Hosting specifically tailored to your needs and requirements, A Small Orange is the perfect solution for your personal website. They follow one single rule which makes sure you pay only for the resources that you need and nothing more. While they are on the raise, ASO is keeping things very personal. Hence they might be one of the best options for you from the list. Notice that A Small Orange is not the cheapest option but all for a good reason. Either you go with the cheapest shared plan or WordPress exclusive, you will pay at around $5 per month.
With email hosting from IONOS, each package features full IMAP support so you can easily retrieve your mail wherever you may be. IMAP (Internet Message Access Protocol) allows you to synchronize your email across many different devices, including your computer, smartphone, and tablet. You'll enjoy maximum flexibility in your ability to answer and organize your email while you're on the move. At the same time, you have peace of mind knowing that with IONOS email hosting all your communication is safely stored on our secure servers. Email hosting with IMAP functionality also allows companies to set up multiple email accounts for employees while encouraging greater cooperation through a simplified communication system. Each user can define their own settings within their preferred IMAP program on each individual device. This gives users greater autonomy, allowing them to use personal organizational systems that they are familiar with. Finally, IONOS email hosting provides full webmail access to complement our IMAP functionality. This means that should you be temporarily unable to access your usual devices, our email hosting allows you to easily retrieve your emails from any available web browser — the perfect way to ensure your important emails are always accessible.
Website builder: While most hosting providers offer website builder as a standard feature, not every builder is created equal. For example, some web hosts only allow you to build a basic websites with their builder, whereas others even let you launch an online store with it. The key is to figure out whether their builder comes with the right set of features you'll need.
Many web hosting services offer a low "starting price," but require you to prepay for two or three years of service to get that price. After the promotional period, the renewal price for some web hosting services can be two, three, or even four times the initial promotional pricing. While the initial deal might be incredible, the cost of transferring your site (or paying the added fee) in a couple of years may be something to consider.
If you're looking for a long-term solution, a low-cost hosting plan with providers like DreamHost that offers a .com URL is a wiser option. However, if you're looking for a simple informational website and aren't particularly worried about expanding or keeping it up for long, biz.nf provides an impressive free service. Click here to get started with biz.nf.
With more than 2 million websites using BH, you know you are safe with the service. They offer you all there is you need, plus a whole bunch of other features. And whenever your website takes off and grows beyond expectation, you can instantly upgrade to a larger plan and keep your site running continuously. FYI, before you even begin, you would need a domain name. If you still do not have one, Bluehost offers you one for free. I told you these guys take care of your project in its entirety.
First of all, IONOS is not a free domain name service provider in general. We usually have very competitive pricing for our domain customers; however, you will not be able to enjoy free domains all the time. The reason we can occasionally give away domains at little or no cost is that our large customer base enables us to attract a lot of registries that work with us.
At this time, if you live or work in a country without a tax treaty with the United States, we ask that you contact us at [email protected] before submitting a Hosted Game. Prospective authors for Choice of Games who are residents of countries without tax treaties with the United States should also let us know that at the beginning of the process. Canada, Mexico, most Western European countries, many Asian countries, and some African and Latin American countries have a tax treaty with the U.S. See full list here: https://www.irs.gov/businesses/international-businesses/united-states-income-tax-treaties-A-to-Z
Unlock a whole new horizon of possibilities for yourself. Impress that new employer with a fabulous online resume and stand out from the crowd. Attract new clients with a gorgeous portfolio and offer your expertness to those in need. It does not require to have a complex website to win. A simple personal page will help you reach new levels of success.
Dedicated hosting is no longer a thing today. There are very little companies that offers that. Most of the serious businesses are hosted on Amazon AWS, Azure or Google Cloud because these services offers better reliability, scalability and tools for the job. Huge websites like Instagram, Reddit, Twitter are hosted within their infrastructure. If you are looking for a serious processing power these services are must have. Or even VPS providers such as Linode and Digital Ocean are great options if you are looking for flexibility.
Shared hosting is web hosting in which the provider houses multiple sites on a single server. For example, Site A shares the same server with Site B, Site C, Site D, and Site E. The upside is that the multiple sites share the server cost, so shared web hosting is generally very inexpensive. In fact, you can find an option for less than $10 per month.
Welcome to the CNET 2020 directory of web hosting services. In this directory, we'll look at a few of the best web hosting providers like Bluehost, A2Hosting, Hostinger, DreamHost, HostGator, InMotion Hosting and more. In this evaluation of the best web hosting providers, we're featuring commercial web hosting companies that offer WordPress, VPS, shared hosting and many more web hosting services, along with a variety of annual and monthly plans.
NameStall is a $10 per month domain generator that stands out by allowing you to curate highly customized domain lists. Input a search term, and then customize the list by choosing various criteria. For example, you can choose to include only nouns, or focus on niches like real estate, transportation, design, or travel and hospitality. You can also choose from among 100-plus extensions. NameStall is best for companies needing niche-specific domain names.


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Origin, phenotype and function of human natural killer cells in pregnancy.
by Vacca, Paola
Trends in immunology, November 2011, Vol.32(11), pp.517-523
Dendritic cell editing by activated natural killer cells results in a more protective cancer-specific immune response.
by Morandi, Barbara
PloS one, 2012, Vol.7(6), p.e39170
Stromal cells from human decidua exert a strong inhibitory effect on NK cell function and dendritic cell differentiation
by Croxatto, Daniele
PloS one, 2014, Vol.9(2), pp.e89006
Melanoma cells become resistant to NK-cell-mediated killing when exposed to NK-cell numbers compatible with NK-cell infiltration in the tumor
by Balsamo, Mirna
European Journal of Immunology, Jul 2012, Vol.42(7), pp.1833-42
NK Cells, Tumor Cell Transition, and Tumor Progression in Solid Malignancies: New Hints for NK-Based Immunotherapy?
by Cantoni, Claudia
Journal of immunology research, 2016, Vol.2016, pp.4684268
Human natural killer cells: origin, receptors, function, and clinical applications.
by Moretta, Lorenzo
International archives of allergy and immunology, 2014, Vol.164(4), pp.253-264
NK cells from malignant pleural effusions are not anergic but produce cytokines and display strong antitumor activity on short-term IL-2 activation
by Vacca, Paola
European journal of immunology, February 2013, Vol.43(2), pp.550-61
Susceptibility of human melanoma cells to autologous natural killer (NK) cell killing: HLA-related effector mechanisms and role of unlicensed NK cells
by Carrega, Paolo
PloS one, 04 December 2009, Vol.4(12), pp.e8132
IL-1β inhibits ILC3 while favoring NK-cell maturation of umbilical cord blood CD34(+) precursors.
by Ambrosini, Paolo
European journal of immunology, July 2015, Vol.45(7), pp.2061-2071
Hypoxia downregulates the expression of activating receptors involved in NK-cell-mediated target cell killing without affecting ADCC
by Balsamo, Mirna
European journal of immunology, October 2013, Vol.43(10), pp.2756-64
Role of NK cells in immunotherapy and virotherapy of solid tumors.
by Cantoni, Claudia
Immunotherapy, 2015, Vol.7(8), pp.861-882
Perturbations of natural killer cell regulatory functions in respiratory allergic diseases
by Scordamaglia, Francesca
The Journal of allergy and clinical immunology, February 2008, Vol.121(2), pp.479-85
Human RORγt(+)CD34(+) cells are lineage-specified progenitors of group 3 RORγt(+) innate lymphoid cells.
by Montaldo, Elisa
Immunity, December 18, 2014, Vol.41(6), pp.988-1000
Update on natural killer cells: cross-talk with dendritic cells and role in the cure of acute myeloid leukemias
by Moretta, Lorenzo
Cancer journal (Sudbury, Mass.), 2003, Vol.9(4), pp.232-7
Natural killer cells kill human melanoma cells with characteristics of cancer stem cells.
by Pietra, Gabriella
International immunology, July 2009, Vol.21(7), pp.793-801
NK cells provide helper signal for CD8+ T cells by inducing the expression of membrane-bound IL-15 on DCs.
by Morandi, Barbara
International immunology, May 2009, Vol.21(5), pp.599-606
Peptides with dual binding specificity for HLA-A2 and HLA-E are encoded by alternatively spliced isoforms of the antioxidant enzyme peroxiredoxin 5.
by Sensi, Marialuisa
International immunology, March 2009, Vol.21(3), pp.257-268
NKp44 expression, phylogenesis and function in non-human primate NK cells.
by De Maria, Andrea
International immunology, March 2009, Vol.21(3), pp.245-255
What is a natural killer cell?
by Moretta, Alessandro
Nature Immunology, Jan 2002, Vol.3(1), pp.6-8


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Players at the Game of People
John Brunner
|About the Book
A savagely lacerating satire, this is an example of the sort of literature of ideas sf was before commercial formulae & interminable series took over. A lot of todays readers wont get it & may be pissed off by its unresolved ending. ButMoreA savagely lacerating satire, this is an example of the sort of literature of ideas sf was before commercial formulae & interminable series took over. A lot of todays readers wont get it & may be pissed off by its unresolved ending. But its a very good story—tho perhaps not quite as good as the socially conscious SF Brunner was producing during his peak a decade previous—& its unapologetic defiance of convention is a breath of fresh air when nearly everything today seems an attempt at a franchise & some authors are happier chugging out Star Wars novels for an easy paycheck than coming up with original sf.Players at the Game of People is an attack on the leisure class, that fundamentally European institution of bygone days translated into a near-future milieu. Godwin Harpinshield is one of a select number whove entered into this quasi-Faustian arrangement with mysterious beings referred to as owners. His every desire is catered to. He always gets the best table, the best women. He can travel across the globe & even, apparently, thru time in the endless & yet increasingly futile pursuit of pleasure. Hes only one obligation: he must recruit someone. This he does by rescuing a pathetic & naturally vulnerable young prostitute from her dead-end lifestyle while she still has a spark of hope & ambition. While it isnt altruistic, this act spells the beginning of the end. Unexpectedly, he meets the girls mother, whos come looking for her. This encounter not only offers up a surprising personal revelation, it also prompts him to be bold about questioning the nature of the owners & what theyre getting out of all this.Brunner deliberately leaves several aspects of his story unexplained, not the least of which is who the owners are. While this wont make those folks happy who have to have boldface explanations for everything, the novel as it is wouldnt have worked as well without these elements of mystery. By leaving certain key questions up for speculation, he puts you squarely on the same playing field with Harpinshield. A book that could have been terribly obscure is made more accessible, not to mention suspenseful. The cynicism wont appeal to all. There are a few early scenes which come off as uncomfortably racist & sexist by todays standards. But readers who appreciate a dark, satirical edge to their fiction—stories that neither let you off the hook easily nor spell everything out—will find this bitterly ironic yet truthful tale a winner.--T.M. Wagner (edited)


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DG6 Kirkcudbright
GL56 Little Compton
RH18 Forest Row
W4 Strand on the Green
BT27 Lisburn
EH1 Old Town
TS24 West View
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| 10.1°C Dublin
We are entitled to ask why government-making talks cannot gather pace sooner rather than later. Enter Covid-19, aka the coronavirus, and let it take its place alongside the Brexit Part II talks which open today in Brussels. Keep those two in mind and add the mass flooding across the country.
Then note ongoing talk of an international economic slowdown, which has been pending for some time for various reasons, but may now be driven by the international outbreak of the virus.
And put all of them alongside these marathon coalition "talks about talks" in the wake of the general election 18 days ago.
We're told the Dáil arithmetic suggests only one workable outcome: a Fianna Fáil, Fine Gael, Green Party - and possibly others - alliance.
Well, if that's it, why not let it happen swiftly? If not, let's look at other less likely options. And beyond that, let's get on with the least-preferred result: a second general election which might end this deadlocked phoney political war.
On the other hand, given the sum of the challenges ahead, why not some kind of national government including Sinn Féin? Since we share the Dáil seats along the lines of vote-share, why not extend that principle to Cabinet seats?
Many seasoned followers of politics will find that statement naive. But so were ideas of Fianna Fáil sharing with the Progressive Democrats in June 1989, Labour's Dick Spring allying with Albert Reynolds and Fianna Fáil in 1992, Fine Gael joining forces with Democratic Left in 1994, and even the current prospect of Fine Gael and Fianna Fáil linking up.
Most of those things happened - it's called politics. If you look at the unlikely government partners across Europe, you will see all kinds of possibilities.
Yes, it certainly has been a very difficult time for all our politicians, who fought a very tough election campaign through late January into the first week of February. The outcome has been the least decisive in the State's history.
Sinn Féin got one in four of the votes - a huge boost from the last election in February 2016, when it got one in seven voters. The party has been busy driving this point home about the unexpected surge in support over the ensuing three weeks.
It is entirely Sinn Féin's right to do that. But let's bear in mind that three out of four voters did not choose Sinn Féin on February 7 last.
Let's not forget also that it is the democratic right of both Fianna Fáil and Fine Gael to choose not to share government with any particular party or grouping.
It is equally interesting to observe that - despite having 37 TDs - Sinn Féin is a huge distance away from pulling a disparate left-leaning government from the 'ABFF-FG' department.
And then, there is the blindingly obvious reality that Sinn Féin would relish a period in well-defined opposition, once again being right about everything that is wrong, and counting down the days to the next election when it could make even more serious gains.
To cite the plummy-sounding score-caller at Wimbledon tennis matches in London, it is very definitely 'Advantage Ms McDonald' right now.
But there is a view among some in Fianna Fáil and Fine Gael that they should do what they can to ensure Sinn Féin gets into government. That less-likely scenario would involve some kind of tactical abstention to allow Mary Lou McDonald and her colleagues to pull together some kind of minority administration. It would ideally allow voters to be reminded that the latest shiny political thing had a rather superficial lustre. We would all be reminded government is much slower, more complex, and much harder than criticising from the opposition benches.
That scenario is about giving Sinn Féin the scope to come up short of voter expectations - just like Fianna Fáil, Fine Gael, Labour, the Green Party and others did in the past few decades. As a government-making scenario, it also seems a little far-fetched.
But if you were going for it, why not go the whole hog and opt for a national government?
The idea would give cover to both Fianna Fáil and Fine Gael to overcome their constant anti-Sinn Féin messaging. Dare we say it, an intensified Covid-19 crisis would deliver a multitude of political cover here.
Micheál Martin especially, and also Leo Varadkar, would be able to climb down from the "never-ever Sinn Féin in government" rock upon which they are marooned. It would also serve to dial down this growing whinge by Sinn Féin members that they - and by extension their voters - are being unfairly driven out of a share in power.
It's a pretty safe bet that Sinn Féin would, in the fullness of time, turn down such a national government offer with many rhetorical flourishes.
It is also true that the process would only add to the time-wasting we have decried at the start of this piece.
But it would still be a valid political exercise and would be worth the effort for many reasons.
It's also odds-on that the national government idea is a total non-starter. It might be filed alongside the naive idea of "work a day for Ireland" which came in April 1980 from the quintessential political tough guy of his day, John Boland. Yep, not only did that not fly, it became a term of popular abuse.
That brings us back to 'Plan A' which is the Fianna Fáil, Fine Gael, Green Party line-up. This is fraught and the path to it is filled with obstacles. After the negotiations, the respective parties' rank and file would have to sign off on it.
But, ultimately, it could be a good and durable government. So, we are back to the question about why our politicians should delay the inevitable government line-up.
We are reminded of Shakespeare's Macbeth reflecting upon the murder of the king to give him the throne: "If it were done when 'tis done, then 'twere well it were done quickly," said the ill-fated Scottish assassin-turned-king. A long-winded way of saying: "Get on with it."
Irish Independent


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text: There are a large number of different disease processes associated with lupus, which can also cause pulmonary issues, as well as impact treatment. For these reasons, patients with lupus can be among the most complex patients that pulmonologists see. Kaner emphasized the importance of partnering with your rheumatologist and pulmonologist to arrive at an accurate diagnosis. Hydroxychloroquine combination arimidex Starting plaquenil Plaquenil sun pharmaceuticals 347 Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling especially of the face/tongue/throat, dizziness, trouble breathing. Certainly lupus respiratory problems involving the lungs and surrounding membranes are more likely as the disease progresses. Symptoms of respiratory inflammation and infection can be as simple as a stuffy nose and sore throat, or severe enough to make breathing painful and difficult. The cough, he conveyed, is usually due to the upper nasal track, which can cause a cough as well as other symptoms. When people present with a re-occurring cough, only 50% of the time does it have to do with your lungs. Kaner spoke with the group about how the lung itself, is not often a cause of specific symptoms, like coughing. Plaquenil and respiratory problems ACR Announcement Coronavirus Disease COVID-19, Plaquenil Oral Uses, Side Effects, Interactions. Hydroxychloroquine arthritis mechanismPlaquenil fkDoes plaquenil cause tinnitusQuinacrine chloroquine antimalarial A very bad and sometimes deadly reaction has happened with Plaquenil hydroxychloroquine. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. Talk with the doctor. Keep away from children. Plaquenil Indications, Side Effects, Warnings -. Lupus Respiratory Problems Common Issues With the Nose.. When to Report Reactions to Plaquenil. Summary Breathing difficulty is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Enbrel, and have Primary pulmonary hypertension. A recent large study of people with cardiovascular disease found that hydroxychloroquine Plaquenil does not increase the risk of infection and methotrexate increases the risk of infection only slightly. The concern with immune suppression is that the virus could replicate more freely and cause more severe or extensive disease, says Dr. Winthrop. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes.


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The Neverclaim comprises Jeremiah Carlson (lead vocals, acoustic guitar), Mitchell Maldonado (keys, banjo, guitar), Chuck Hill (bass, upright bass), Josh Anderson (lead guitar), Matthew Warren (guitar) and Jared Key (drums, percussion). The band first entered the national music scene after winning a talent contest held by radio network Spirit FM. Its unabashed rock sound combined with a pure collective heart for worship resonated with fans and garnered widespread critical praise, earning The Neverclaim tour billing alongside such notable acts as Newsboys and Third Day.
Consequently, it was Third Day's Mac Powell who introduced The Neverclaim to Essential Records, who is now releasing the band's national debut. Produced by Paul Moak (Matt Kearney, Third Day, Matt Maher) and Jason Ingram (Chris Tomlin, Tenth Avenue North, Building 429), The Neverclaim is laden with profound moments of worship, reflecting the group's genuine longing for spiritual revival among this and future generations.
Carlson comments, "Life is more than working and making money. There's a greater story of redemption at work, and God is calling us into that story. He is calling people to their true identity, radical relationship with Him. We're all made for more than mediocrity; God calls us to shift cultures because of His love."
Appropriately, The Neverclaim rips open with the aptly titled "Revival," an anthem boiling over with spiritual intensity and lyrics that tell of a stirring up inside the body, a revolution in our hearts. Similarly, "Burn" speaks to finding life's true fulfillment (We were made for so much more / we yearn for the fire that's inside / Spirit of God burn inside of me) as does the banjo-rocking "My Soul Longs." Other noteworthy tracks include "Be Lifted Higher," a vertical worship anthem and exuberant first single "One Truth One Life." The latter is currently impacting Christian radio. See the lyric video here: http://is.gd/CBHSo3.
The Neverclaim will preview songs from its new record as a guest on Sanctus Real's 20+ city "The Run Tour," kicking off Sept. 19. Visit www.TheNeverclaim.com for a complete list of tour dates. The group will also appear at all three 2013 National Worship Leader Conferences (its last independent release was touted by Worship Leader magazine as one of the "Top 15 Worship Releases 2012"), the Vineyard Church Pastors conference, Experience Worship Conference and other worship events.
For more information on The Neverclaim, visit www.TheNeverclaim.com, www.facebook.com/The Neverclaim, @TheNeverclaim
For more info on The Neverclaim visit the JFH Artists Database.
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