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|This ministry has a distinct kingdom vision, identifying with God's call and plan for Israel and the church. My position is pre-trib! I was saved in 1976 while working as a war correspondent, journalist, photographer, artist and environmentalist. My calling is to share with you the great end-time dramas, to stand as a watchman and above all, to glorify my God.
►We have now reached 46 million regular visitors.
►Next Edition, Lord willing: "Foreboding Forewarning."
- Covid 19 virus is still spreading worldwide. Watch for this to level off. Watch for the infection rate to begin to decline. It will happen and soon. Watch for many leaders to turn to God. Some are!
- China is to lift lockdown on April 8th as 1.5 billion worldwide go into lockdown.
- This pandemic is going to take a large chunk out of world economic growth and set back nations and people already struggling.
- Interestingly the word "Corona" means "crown" it is also a fiery ring surrounding the sun visible at an eclipse. Does it symbolise a crown of fiery judgement?
►►Please watch this most important video clip by Jonathan Cahn entitled "The Return"
►►►Regular readers of The Prophetic Scroll are hereby informed that this Covid19 virus will not come near you. I and my prayer team are praying this as a specific prayer of protection over you.
These will change on Sundays or as the Lord leads.
Revelation 18:4 "I heard another voice from heaven saying, 'Come out of her My people, lest you share in her sins, and lest you receive her plagues."
Isaiah 52:11 "Depart! Depart! Go out from there, touch no unclean thing; go out from the midst of her. Be clean, you who bear the vessels (word) of the Lord."
Isaiah 41:10 "Fear not, for I am with you; be not dismayed, for I am your God. I will strengthen you, yes I will help you, I will uphold you with my righteous right hand."
Psalm 34:19 "Many are the afflictions of the righteous, the Lord delivers him out of them all."
Shabbat (Sabbath) begins on Fridays at 6pm and ends on Saturdays at 6pm. The purpose of this report is to help the church and Israel become reconciled in Messiah.
27th March 2020
Shabbat Shalom to all!
Watchmen who spy with their little eye:
A major goal of The Prophetic Scroll (TPS) is to be ahead of the curve. It is to have eyes looking into the future. It is to hear the word of the Lord and to inform and warn of things to come.
Here at TPS you will find teaching and encouragement for your heart and your head. You will be kept safely in the arms of our Lord, through the work of the Spirit of God.
The spread and growth of the coronavirus is often represented as a curve in a graph, with the largest numbers at the peak of the curve.
I have some good news for you:
The coronavirus has run its course and is over! You might think I'm mad! Well, there are two issues here. Firstly, that is the sense I get from the word of the Lord. Secondly that is what the graphs and charts are saying.
Of course it's not over in reality yet, but the curve in most places has peaked. You may surprised to know that China's Wuhan Province where the virus started and killed many is already back to normal with all services, factories transport and industries back to normal operation. (Look it up) Other nations are seeing a flattening of the curve after the peak. A few are still seeing an increase.
We are to look out into the future and not right at our noses. Yes I do believe there is going to be a lot of difficulty ahead, but the human spirit has strong bounce-back ability.
Stock markets are always anticipatory of future economic fundamentals. They price in the future now. We have seen world markets crash and then crash again. But in the last week or so they have registered repeated record runs higher, including the largest ever one day point gain in history on the Dow.
Markets create many signals including the reliable "key reversal signal" which is a capitulation to the downside and a "V" shaped spike higher forming a number of higher highs on the charts. This is just what we have now.
Can the markets still go down? Yes they can take another hit, but the main, furious downside is over.
All the pessimists including Christian pessimists can only see the reality of sick, dying and dead people everywhere! They can't see the light in the tunnel because they are the dark tunnel.
The mass media have created a no-man's land riddled with mine-fields saying, 'don't resist our opinions'. They have created a fortified 'city' full of so-called giants of their own opinions.
Let's put this into spiritual terms with our two good friends of antiquity – Joshua and Caleb.
Joshua and Caleb:
These were two of the twelve spies sent by Moses to spy out the Promised Land of Israel.
This story relates prophetically to Israel's future salvation, and also applies to God's promises for the Christian.
We should all know the story. All the spies saw the same thing which was a land flowing with milk and honey, but with big giants and fortified towns. Ten came back and accurately reported what they saw and thought. They said that it was impossible to defeat these giants and the fortifications.
Joshua and Caleb saw the same things but in faith, looked beyond and came back with an outrageous, radical, good report in light of all the bad things. It defied eyes, ears and logic!
We have exactly the same picture with David and Goliath, which speaks very much of Israel's fight for survival today.
Joshua and Caleb refused to see themselves as submitted grasshoppers controlled by evil.
The ones who went into the Promised Land had wholeheartedly followed God.
The ten evil spies had significant influence. They held the majority consensus, because they thought they could see with their eyes. The Bible says that the caused the entire congregation to murmur. (Numbers 14:17-38)
The ten with the evil report led the entire camp of the children of Israel to banishment by God in the wilderness, where they all died of the plague. Joshua and Caleb were the ones to lead the new flock into the land.
The ten spies are represented in the mass-media. They see with eyes that cannot see.
Tragically, much of the church today not only carries the virus of the ten evil spies relating to Israel, they actually facilitate it with their anti-Semitism and replacement theology.
You must have spiritual eyes to hear God's trumpet warnings, or the holy, golden, shining sword is coming your way fast. (Deuteronomy 32:41, Ezekiel 21:9)
I believe that's not politically correct today to say a sword is coming! – Voetsak!
Two pretty neat watchmen!
The twelve spies were sent to spy out the land. Only two of the ten were God's watchmen.
●The word "spy" is Strong's H8446 meaning to seek, search and explore.
●The word "watchman" is Strong's H6822 meaning to keep watch, or to spy out and observe. Note that the meanings are almost identical.
Today we have many self-proclaimed watchmen. They are part of the ten evil spy network! They spy out what they see. They report on what they see and speculate with variables. They are repeatedly wrong. (I heard of one who recently claimed that the rapture would take place on Purim, because that's when Jews get drunk in the streets! – What garbage!)
Some people are so thickly deceived that even if you show them the truth, they will still believe a lie. That is because deception is primarily an evil spirit, which becomes imbedded if not cut out.
So, if the Covid 19 story is on the way out, have we learned the lesson? Many have. Many are talking of national repentance. Many joined for urgent prayer and still are. But many have not. These are those who never will. They are the doomed ones. Please don't be one!
How many large biblical abominations present in the nations, that led to their national curses will go? Very few will!
What is important and coming soon is the next round of catastrophic judgment on this world. This is because of the overall place we are in prophecy. It will speed up.
The truly blind media and their blind sheep have denied God and His word. They have by extension denied mankind the ability to see sin, wickedness and abomination.
►Here is a most powerful lesson for you in these days:
Deuteronomy 8:2 "The Lord your God led you all these forty years in the wilderness to humble you and test you, to know what was in your heart. Verse 16: He might humble you and test you to do you good in the end."
Psalm 106:14-15 "They soon forgot His works, they did not wait for His counsel, but lusted exceedingly in the wilderness and tested God in the desert, so He gave them their requests, but sent leanness into their soul."
Some of these end-time things are great surgical tools for your heart!
Psalm 71:20-21 "You have shown me great and severe troubles, You shall revive me again, and bring me up again from the depths of the earth. You shall increase my greatness and comfort me on every side."
2 Kings 6:16 "Do not fear, for those that are with us are more than with them." The Lord opened their eyes to see mountains full of chariots of fire all around Elisha!
Welcome to TPS – your very own Joshua and Caleb for today's exciting and unique times!
✡† Shalom...Joel.
Edition 455: February 5th 2019
Messages from heaven:
Due to the lateness and urgency of the hour and the prompting of the Spirit of God, with confirmation from my main prayer partner, I must deal more fervently with Israel right now.
These messages are essentially for those left behind after the rapture, both Jews and Gentiles
So, I encourage you to save them, or print them out or do what you feel necessary for them to fall into the hands of people in the tribulation period. But they are also for us all now.
I received an amazing email from a friend, supporter and reader. She said: "The Prophetic Scroll will be very much recognised by the native olive branches (Israel) as they burst into bloom just after the rapture. I encourage you to be even more mindful of our Jewish brothers and sisters, almost like a baton being handed over to those who will run with it."
The rapture ends the church dispensation and begins the final seven years of the Old Covenant period, now on hold, called Daniel's 70th week. (of years) It is also called "The time of Jacob's trouble" and the "tribulation."
The seven-year tribulation marks huge dispensational changes in God's dealings with the world. This is when Israel becomes the main focus of prophetic things. "All Israel will be saved." ("All "being the entire remnant, and not every single Jew) Huge numbers of Gentiles will also be saved.
God has chosen you, Israel for a grand purpose:
Here is the purpose in a nutshell:
Israel: ●Elected ●Rebelled ●Rejected ●Regathered ●Repented ●Accepted.
But it does not end there. After the "acceptance" comes God's grand finale, which is Israel being used as His instrument to bring salvation to the world.
Israel, stand strong and look to your God. As you repent, your eyes will open to your glorious Messiah and His grand plans for you.
Your calling is holy and sure. (2 Timothy 1:9) Be secure in that.
Yes, you were chosen ages ago to be God's witnesses of His good news to the world. He has not forsaken that promise, and now it is your time, Israel.
Joshua 21:45 "Not a word failed of any good thing which the Lord had spoken to the house of Israel. All came to pass." (Joshua 23:14)
Exodus 19:4-6 "You (Moses) have seen what I did to the Egyptians, and how I bore you on eagle's wings, and brought you to Myself. Now therefore if you will indeed obey My voice and keep My covenant, then you shall be a special treasure to Me above all people; for all the earth is Mine, and you shall be to Me a kingdom of priests, and a holy nation."
God's ultimate purpose for you Israel, and you, dear Christian, is to "bring you to Himself!"
The command from God to the world:
"Let My people go so that they may worship Me." (Exodus 5:1, Exodus 8:1, Exodus 9:1)
The world, blinded by its pride and its god, will intensify its stand against you, Israel, but the world has chosen the wrong way, and you Israel, with God's help will bring many in the world to their knees in salvation, and the rest to their knees in defeat.
We know the story of the birth of the Arab / Israeli conflict. It started in Rebecca's womb at the birth of her twins Esau and Jacob. Esau, being the first born of the two, had the birthright, which included the land. Jacob had his name changed to Israel and became the father of Israel and the Jews.
Esau was the father of the Arab nations, which today would include the Palestinians. He did not respect his birthright and sold it (a legal transaction) to Jacob. (Genesis 25:23)
But now we have the arising problem: Esau wants his birthright back! The nations of the world in their blindness are assisting Esau's lies claiming that they have a right to the land.
In this very simple, easy to understand situation, we have the entirety of the Arab (Palestinian) / Israeli issue encapsulated. It all began in Rebecca's womb and will end at Armageddon!
The world wants Israel to capitulate to Arab / Palestinian demands for land, or do they? That's the smoke screen! The world and its god, Satan wants to destroy God's plan for Israel, to be saved, and to bring salvation to the world, and worship to the true God.
God's divine election relating to Israel, smashes the god of democracy in the head. Modern, intellectual, liberal, humanism claims Israel for the world, but God claims Israel as His!
- Embezzlement: Misappropriation of another's possessions to take ownership thereof.
- Larceny: Theft of property of another to permanently deprive the legitimate owner, under false pretences.
These terms could well be applied to the Palestinian claim to the land of Israel and Jerusalem. They call it the "occupation" of what they deem to be their land, by Israel. But God has occupied the land by His word and with His many promises to Israel.
Their well-used methods are simply indoctrination, propaganda, or revolution by gradualism!
So, world – "Let My people go," from your insanity. Just like Christians, they will never be yours!
World, please read this verse below and note your great failure and who gets let go!
Zechariah 8:22-23 "Many peoples and strong nations shall come to seek the Lord of hosts in Jerusalem, and to pray before the Lord. In those days, ten men of every language of the nations shall grasp the sleeve of a Jewish man, saying, 'Let us go with you, for we heard that God is with you."
You see world, you won't "let My people go," to fulfil their God-given call. But God will destroy you and they will go to Him. Then His eternal promise will come to pass as many within the nations come to Israel to be turned to the living God.
Say hello to your coming doom, world!
Psalm 114:7 "Tremble, O earth, at the presence of the Lord, at the presence of the God of Jacob."
World peace... hell's way:
- Lenin (One of the architects of communism): "World peace is communist world control."
- Islam: "World peace is an Islamic world with no resistance, and Sharia law ruling."
- Hitler: "World peace will come for a thousand years under Nazi rulership."
- Catholics : We will bring world peace into being."
- Antichrist: I will control the world, its religions, and its economy by strength and domination. (Isaiah 10:13-14, Revelation 17:17, 13:7)
The common denominator here is forced control with the Jews enslaved, removed or killed, so that God's plan will be frustrated. That is the way of Satan, and nothing has changed.
►Hitler's mentor, Dietrich Eckart, an occultist, when he first met Hitler said, "Here is the long awaited Messiah!" Eckart became known as the "High priest of the Nazis". (With no Jews.)
►Interestingly, Constantine, the main architect of the Catholic church called himself Pontifex Maximus, meaning, the high priest of the heathen.
But God said of Israel (the Jews) "You will be to Me a kingdom of priests and a holy nation. (Exodus 19:6) (The true church also bears this title.)
Isaiah 61:6-7 "You (Israel) shall be named the Priests of the Lord, men shall call you the Servants of our God. You shall eat the riches of the Gentiles and in their glory you shall boast. Instead of your shame, you shall have double honour. Therefore in their land, they shall possess double; everlasting joy shall be theirs."
World peace will arrive when God's plans for Israel and Jerusalem are fulfilled.
World, you are soon going to make your great fatal, fateful mistake on the plains of Israel and in the city of Jerusalem! (Zechariah 12:3) World, why are you so stupid that you can't even see the pattern in history which has already happened, never mind your future reflected in that history?
A message to the world's mass-media:
You are and will do the works of your god. You are doomed.
King David had a trusted counsellor named Ahithophel. But he arose in pride and became bitter and gave David the wrong advice. In many ways Ahithophel was a type of the voice of the media.
2 Samuel 15:31 "They told David, 'Ahithophel is among the conspirators with Absalom.' So David prayed: 'O Lord, turn the counsel of Ahithophel into foolishness."
Interestingly, the name 'Ahithophel' means "Brother of ruin and foolishness."
Mass-media, your proud counsel is your own ruin and foolishness!
►A wise believer will pray for the counsel of the media to be turned to foolishness in his own lifel, and not be influenced.
There is another important message here: Ahithophel was an insider. This is a powerful type of the churches of replacement theology and their evil counsel. They are a Trojan.
One of the main aims of the false church will be to obstruct God's plans for Israel. This is why the mass-media loves false, fallen religion.
Being an ex media man myself, I have a heart for them. My prayer has always been that some get saved. I know some who have, but the great majority will not because of the nature of the industry and its connection to the world-system.
Those in the media who have seen the light, and will in the tribulation period – you will have a new powerful role, with new insight and understanding. Glory to you!
Where did the chariot go?
Elijah was walking along with Elisha and a whirlwind appeared, and suddenly Elijah was raptured up to heaven in a chariot of fire within a whirlwind! (2 Kings2 11-12)
But this was an odd chariot. Elisha, in his shock, called it the "chariot of Israel."
This occurred just after Elijah's miracle of the parting of the water, so that he and Elisha could cross on dry ground at a place called Gilgal (2 Kings 2:8)
Gilgal is where the Israelites crossed into the Promise Land (Joshua 4:1-9)
So what we have here is a type of the rapture, just as the children of Israel cross into their new, spiritual promised land.
The rapture is the shock that will cause the Jews to become jealous and angry, leading to their salvation. (Romans 10:19) The rapture is a "chariot" carrying a spectacular message to Israel!
The rapture is a "banner" and a baton!
The great danger for the world and the church:
It is a huge thing to come against the Jews and God's plans for them. You will be cursed. That applies to individuals and entire nations. Anyone blessing Israel will be blessed, and anyone cursing Israel will be cursed. (Genesis 12:3, Numbers 24:9)
We see that Pharaoh refused to release the Jews when Moses commanded him to. This was the reason God hardened his heart. After God's intervention he did "let My people", but then still pursued the children of Israel, leading to the deaths of his own armies in the Red Sea.
Due to Israel's rebellion they too had their hearts hardened, which is evident even today. (Ezekiel 3:7, Hebrews 3:8) What a terrible thing to have a hardened heart in these days!
Ephesians 4:17-18 "Do not walk as the rest of the Gentiles do in the futility of their mind, having their understanding darkened, being alienated from the life of God, because of the ignorance that is in them, because of the hardening of their heart."
A hard heart is the open door for demons and spirits of anti-Semitism, replacement theology and Jew hatred in these days.
Beware; these are powerful, evil spirits at work. You can't reason with them. You will succumb. You must cast them out of your own life.
The funny thing is the very opposite of replacement theology will be the order of the day, in the tribulation period. The Jews will be the main focus of the work of God and the left-behind religious elite become part of the false prophet.
The early church reached the whole known world then. (Colossians 1:23) Then came the Catholic-created dark ages, replacement theology, anti-Semitism and Jew hatred, by the fallen church. The Jews as God's evangelists in the tribulation will reach the whole world with gospel!
The word "inextricable" means, "Impossible to be separated." It applies perfectly, inextricably to Israel, Jerusalem, the Jews and God's irrevocable call and plan. You can't remove it. (Romans 11:29)
The world would like Israel to become part of their world – not called, and not chosen, with no separate, holy, godly, calling and destiny. That's why the world hates them!
Israel's birth-pangs and spiritual birth:
A birth is a painful experience, but produces victory. What the world is trying to do now is abort the process and kill God's work in His people. No wonder Satan's world supports abortion.
Israel, the people and the city have suffered much through history. The birth is about to manifest.
Suffering makes you beautiful! It may not make you pretty, but it makes you deeply beautiful.
Isaiah 52:1 "Awake, awake! Put on your strength O Zion; put on your beautiful garments, O Jerusalem, the holy city."
Yes, Israel, you are on the way to eternal, deep, spiritual beauty, but there are pains to endure.
Isaiah 61:3 "To them who mourn in Zion, I will give them beauty for ashes, the oil of joy for mourning."
Zechariah 13:8-9 "It shall come to pass in all the land, says the Lord, that two thirds of it shall be cut off and die, but one third shall be left in it. I will bring the one third through the fire, will refine them as silver is refined, and test them as gold is tested. They will call on My name, and I will answer them. I will say; 'This is My people'. And each one will say, 'The Lord is My God.'"
Some say that above verse relates to various historic events and wars like the Holocaust, but not so. It is prophetic because of the fact that the remnant are brought to salvation in Messiah, which is still future.
This verse above, speaks of part of the coming new Holocaust in which Israel will suffer great loss, but only temporarily on her way to victory.
Today the majority of the world's youth know nothing of the Holocaust, or of the Messiah. The youth of Israel know all too well about the Holocaust, but they don't know the Messiah (yet)! That is all about to change.
Zechariah 2:8 "Thus says the Lord of hosts: He has sent Me after glory, to the nations which plunder you, for he who touches you (Jerusalem) touches the apple of His eye."
As the birth approaches Israel repents.
Hosea 10:12 "...Break up your fallow ground (hard hearts) for it is time to seek the Lord, till He comes and reigns righteousness on you."
Romans 11:25-27 "I do not desire, brethren that you should be ignorant of this mystery, lest you should be wise in your own opinion, that hardening in part has happened to Israel, until the fullness of the Gentiles has come in. And so all Israel will be saved, as it is written: The Deliverer shall come out of Zion, and He will turn away ungodliness from Jacob. For this is My covenant with them, when I take away their sins."
The world (Pharaoh / Egypt) will not repent of their hard hearts. Israel will repent!
Ezekiel 36:25-27 "I will sanctify My great name, which has been profaned among the nations, which you (Israel) have profaned in their midst. The nations shall know that I am the Lord, when I am hallowed in you before them. I will take you from among the nations and gather you out of all countries, and bring you into your own land. Then I will sprinkle clean water on you, and you shall be clean; I will cleanse you from all your filthiness and from all your idols. I will give you a new heart and put a new spirit within you...I will put My Spirit within you..."
Ezekiel 39:29 "I will not hide My face from them anymore; for I shall have poured out My Spirit on the house of Israel, says the Lord God."
Israel, today you are blind to the beautiful painting that you are. One day very soon, as the veil lifts you will see your own spiritual beauty! Jump for joy Israel!
Israel: Magnificent promises:
Isaiah 49:6 "I also will give you (Israel) as a light to the Gentles, that you should be My salvation to the ends of the earth."
Isaiah 49:16 "See I have inscribed you (Zion) on the palms of My hands; your walls are continually before Me."
Isaiah 62:4 "You shall no longer be termed forsaken, nor shall your land be termed desolate."
Isaiah 62:12 "They shall call them (Israel) the Holy People, the Redeemed of the Lord; and you shall be called Sought Out, a City not Forsaken."
Acts 13:47 "I have set you (Jews) to be a light to the Gentiles that you should be for salvation to the ends of the earth."
Isaiah 60:2-3 "Behold the darkness shall cover the earth, and deep darkness the people; but the Lord will arise over you (Jews), and His glory will be seen upon you. The Gentiles shall come to your light, and kings to the brightness of your rising."
The big, well-used (rightly so) chant of the Jews is "Never again" in relation to the Holocaust. But God is saying "Never again" too. He is saying; "Never again" will My people forsake Me. He is saying, "Never again" will I forsake them or their land or their city!
When the author walks onto the stage, the play is over.
I took the background picture in the Etosha desert and the white rhino in KwaZulu Natal and blended them together.
Shalom and grow in His Grace!


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Statistics and meaning of name Keeby
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Keeby first name was found 7 times in 1 different countries. (USA)
Surname Keeby is used at least 69 times in at least 1 countries. (USA)
Keeby reversed is Ybeek
Name contains 5 letters - 60.00% vowels and 40.00% consonants.
Anagrams: Ebkye Ykebe Kebye Kebey Eebyk
Misspells: Keebi Keebya Keeyb Kebey
Rhymes: hereby thereby whereby phoebe freebie freebee greedy needy
Meaning of this name is unknown.
This page has been visited from the following countries:
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Writers: Margaret MacKeeby, Jo McKeeby Phillips, Richard McKeeby
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Do you know more about the meaning
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subset: commoncrawl


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UX Designer
dynaTrace software in Detroit, MI
- Industry: Information Technology - UX/UI Designer
- Type: Full Time
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The software services developed in Digital Business range from the Dynatrace product administration portal, to customer intelligence tools, to various communication and support functions. With these digital services we get deep insights into the customer journey enabling us to offer proactive support and services, identify new business opportunities, drive operational excellence and ultimately ensure customer success. The R&D team focuses on a BizDevOps (Business, Development, Operations) approach to software development that encourages developers, operations staff and business teams to work together so the organization can develop software more quickly, be more responsive to user demand and ultimately maximize revenue.Why work at Dynatrace:Dynatrace provides you with continuous growth opportunities in an environment catered towards learning, creativity and innovation. We pride ourselves on working hard and having fun! With a flat hierarchy mindset, you are enabled to voice your opinions, take ownership, and drive your own success. You will get to work in the heart of Detroit, the next tech-hub of the US where you are provided with easy access parking to Ford Field. We have an open, casual office with a heavy sense of community, collaboration and fun. A few perks of our office and Dynatrace can be seen below and check out Dynatrace Life on Twitter and Instagram. The Role:As a UX Designer, you will join a collaborative, global UX team with a mindset of " the full user experience." This shared mindset allows the team to truly think and collaborate about the entire user experience from concept to design to deployment. Own the end-to-end UX lifecycle and continuous improvement on the digital business platform. The future of the digital business platform includes a "one-stop" shop for the customer experience to unify administration tools, billing & accounting services, product intelligence and more.Qualifications/Requirements:Experience with wireframes and story mapsDesign experience from concept to completion on complex user interfacesProven knowledge on information architecture and user flowsDesign mocks experience using Sketch and interactive click mocks in InVisionExperience with user tests, customer feedback and analyticsKnowledge of web front-end developmentWhat will make you stand out:You think in information structures, data hierarchies, user flows and usability principlesMindset to strive for visual clarity, simplicity, consistency, balance, and beautyAre a team player, problem solver, and proactive doerExperience with agile development methodologiesHave a portfolio with proven design workPerks and Benefits:Great Medical Benefits including Health, Vision and DentalAwesome Work/Life balance with a generous PTO/Holiday packageProvided with excellent hardware/software for you to be successfulBarista-Quality coffees and teas providedFresh fruit provided on WednesdaysFree snacks to keep you energizedSubsidized drinks including sodas and energy drinksContinued education assistance and moreDynatrace provides software intelligence to simplify enterprise cloud complexity and accelerate digital transformation. With AI and complete automation, our all-in-one platform provides answers, not just data, about the performance of applications, the underlying infrastructure and the experience of all users. That s why many of the world s largest enterprises trust Dynatrace to modernize and automate enterprise cloud operations, release better software faster, and deliver unrivaled digital experiences.We offer competitive compensation, company-sponsored premium benefits, medical, dental, vacation/holidays, company matching 401(k) Plan, etc. Dynatrace is an equal opportunity employer and VEVRAA Federal Contractor. We consider all qualified applicants of diverse background and hire without regard to race, color, gender identity, religion, national origin, ancestry, citizenship, physical abilities, age, sexual orientation, veteran status, or any other characteristic protected by law. If your disability makes it difficult for you to use this site, please contact ...@dynatrace.com. Dynatrace participates in E-Verify, participant information in English and Spanish. Right to work information in English and Spanish. EEO is the Law/EEO is the Law Supplement.Note to Recruiters and Placement Agencies: Dynatrace LLC (Dynatrace) does not accept unsolicited agency resumes. Please do not forward unsolicited agency resumes to our website or to any Dynatrace employee. Dynatrace will not pay fees to any third party agency or firm and will not be responsible for any agency fees associated with unsolicited resumes. Unsolicited resumes received will be considered property of Dynatrace.Detroit, MichiganDevelopment R&DEmployee - REG
Associated topics: gui, interactive producer, interface, ui designer, ui ux designer, user interface, ux, ux designer, ux ui designer, wireframing
Associated topics: gui, interactive producer, interface, ui designer, ui ux designer, user interface, ux, ux designer, ux ui designer, wireframing
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Did you know, half of Americans with glaucoma don't know they have it? Glaucoma is often called a silent thief of sight because the early stages often have no symptoms. In the US glaucoma is the second-leading cause of blindness.Read more
Perfect Glasses For Your Lifestyle
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Myths and Facts: Contact Lenses
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Eye Allergies in Every Season
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The official Twitter of 9NEWS in Denver, CO. Interact with us! #BeOn9 #9WX We also retweet the #9NEWS team.
Mayor Hancock: 'Plan on' Denver's stay-at-home order going through April 30
'Star Wars' actor and dialect coach Andrew Jack dies of coronavirus at 76
39 tigers, 3 bears from the 'Tiger King's' roadside zoo are now in Colorado
Michael Porter Jr. to represent Nuggets in NBA 2K tournament
Survey: Healthcare workers worried about bringing COVID-19 home to their families
6.5 magnitude earthquake rattles Idaho and 6 surrounding states
Daniels Fund announces winners of 2020 scholarship
Cub scout 'heartbroken,' kicked out of his den for asking Colorado state senator tough questions
A tractor pursuit just ended in downtown Denver...
Hank Aaron on whether he would visit White House: 'There's nobody there I want to see'
UPDATE: -2 suspects in custody, possibly a third on the loose. -"Multiple" students hurt. -This is still an active situation. -Police asking parents not to go near the school. They won't be able to get near the building. -Some wounded students still on scene, will be transported
As sentencing looms, Michael Flynn is upbeat, has adoring fans


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It is with great disappointment that all Junior Leagues have been told to terminate their seasons with immediate effect. Following recommendation from the FA and in line with all Junior Leagues there is no option but to void the 2019/20 season. Accordingly there will be no promotions or relegations. This will be hugely disappointing for all the players, coaches, club volunteers, parents and the League who have all played their parts in facilitating grassroots football. However, people are dying at an alarming rate. In the grand scheme of things cancelling grassroots football is a mere inconvenience.
Thank you for your understanding. Stay Safe and we look forward to seeing you next season.
The FA understands that, at times like these, things can be difficult. That's why we want to play our part to inform, entertain and empower our millions of fans, followers and those involved in the game under one, consistent banner. Football's Staying Home brings together players of the past and present – as well as experts from our national football centre, St. George's Park – to keep your mind and body healthy and active while you're at home.
Introducing #FootballsStayingHome!
We'll let our captains tell you more. Over to you, @stephhoughton2 and @HKane... pic.twitter.com/ATbKoh0Rlw
— England (@England) March 30, 2020
Click below to explore how you can make the most of football while staying at home
You can also keep up your match fitness by training at home with the Nike Training Club App - the personal trainer that's always there for you. Discover the workouts and training plans expertly designed by Nike Trainers to keep you fit and healthy so you're ready for when football returns!
Papa John's Pizza Ad filmed at Grange Park
Eagle eyed TV viewers may have noticed something familiar about the new Papa John's Pizza commercial. The ad was filmed at Grange Park in the autumn of 2019. If you look closely you may spot some of our players in the background.


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During your first visit to China you will first be, or have been, overwhelmed by the number of people. It is one thing to talk about 1.6 billion people, but it is a whole different animal to see them hustling and bustling and bumping and pushing into…you. In the west, personal space may be about two feet. If you stand behind someone in line, you probably aren't going to get much closer than that without starting to feel a little uncomfortable. In China, personal space equals exactly zero. There is no qualm or notice about standing in line or on the bus with bodily contact. Traffic space (between cars and buses) is equally small, often getting down to millimeters, but, amazingly, rarely actually touching.
Publicly, China is very impersonal
This leads to a different way of thinking. In public, the feeling is very impersonal. Chinese seldomly use words like please or thank you with people they don't know. To that point, I was on a subway during rush hour in China about 6 years ago. I had been to China about 15 times by then, so I had a pretty good understanding of the rules and I knew that I had to be ready for my stop. The subway car was packed, but there was only one person in between me and the door, a golden opportunity. I was ready. When those doors opened, my foot followed my predecessor's by inches. But, even with all my preparation, I was too late.
Ode to Hockey Lady
I'm still not exactly sure how she did it, but an elderly lady about four and a half feet tall, hair pulled back into a chaotic pony tail behind her, came barreling into the car and gave a shoulder check to my hip bone strong enough to push me back into the car. Put a stick in her hand and she might be a solid addition to the NHL.
"Walk on the left", Really!
Scenes like this are common, cramming into buses, cutting in lines, mass movement in seemingly random patterns sometimes…but times are changing. At the World Expo, Shanghai took note and had volunteers standing at the subway escalators informing riders to stand on the right, walk on the left. I was so impressed, but didn't actually take it seriously. It seemed like such a long way to go to get to that point. "What?, really? You actually expect people to be able to walk on the left?". I stood there, on the left, showing my glowing approval, telling the volunteers what a great and important job they were doing until the momentary stun from my speaking to them in Chinese wore off and they earnestly told me to scoot the heck over. Kudos to you, 'Walk-on-the-Left' girls!


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Hot Or Cold Wallets, How To Successfully Store Your Bitcoins?
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The formal insertion of alkenes into aromatic chloro- and bromoalkynes takes place under cationic gold catalysis. This haloalkynylation reaction can be performed with cyclic, gem-disubstituted and monosubstituted alkenes, using BINAP, triazolo[4,3-b]isoquinolin-3-ylidene ligands or SPhos, respectively. The products were isolated in moderate to excellent yields and with complete diastereo- and regioselectivity; the halogen atom bonding the more substituted carbon of the alkene. Preliminary experiments showed that the enantioselective haloalkynylation of cyclopentene can be performed with (S)-BINAP to afford the insertion products with moderate to good enantioselectivities.
BACKGROUND: Contrast enhancement (CE) is found in 10-60% of low-grade gliomas. Its prognostic significance is controversial, and its correlation with IDH mutations and 1p/19q codeletion is elusive. The aim of this study is to investigate whether CE is associated with molecular characteristics of low-grade gliomas and uncover its prognostic value. MATERIALS AND METHODS: All confirmed histological cases of low-grade gliomas diagnosed at our institution between years 2000-2016 were reviewed (n = 102). Spinal and brainstem localization, only-biopsied tumours with ring-like enhancement and incomplete medical records were excluded. RESULTS: Mean age was 42 years ( ± 13.9 years), and 63.6% were male. The median follow-up time was 79.8 months. CE was present on 25% of preoperative MRI, and 25% of patients were considered high-risk according to Pignatti score. Most were astrocytomas (67%) and 87.2% were surgically removed. IDH mutation was found in 64.6% of tumour samples, and 18.8% had a 1p/19q codeletion. No subgroup differences were observed according to CE except for presurgical performance status and postoperative chemotherapy. IDH status and 1p/19q codeletion were evenly distributed. On univariate analysis, age, size > 6 cm, CE, extent of resection, Pignatti score, IDH mutation and 1p/19q codeletion were significantly associated to OS. On multivariate analysis, only CE and IDH status were independently associated to OS. CE remained a significant prognostic factor in IDH-mutant non-codeleted tumours when analysed by tumour subtype. CONCLUSION: CE in low-grade gliomas provides prognostic information in IDH-mutant non-codeleted tumours, although its meaning remains uncertain in IDH-wildtype gliomas.
AssuntosDeleção Cromossômica , Meios de Contraste , Glioma/patologia , Aumento da Imagem/métodos , Isocitrato Desidrogenase/genética , Mutação , Adulto , Biomarcadores Tumorais/genética , Cromossomos Humanos Par 1/genética , Cromossomos Humanos Par 19/genética , Terapia Combinada , Feminino , Seguimentos , Glioma/genética , Glioma/terapia , Humanos , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Gradação de Tumores , Taxa de Sobrevida
Cognitive decline is a major disabling feature in Parkinson's disease (PD). Multimodal imaging studies have shown functional disruption in neurocognitive networks related to cognitive impairment. However, it remains unknown whether these changes are related to gray matter loss, or whether they outline network vulnerability in the early stages of cognitive impairment. In this work, we intended to assess functional connectivity and graph theoretical measures and their relation to gray matter loss in Parkinson's disease with mild cognitive impairment (PD-MCI). We recruited 53 Parkinson's disease patients and classified them for cognitive impairment using Level-1 Movement Disorders Society-Task Force Criteria. Voxel-based morphometry, functional connectivity and graph theoretical measures were obtained on a 3-Tesla MRI scanner. Loss of gray matter was observed in the default mode network (bilateral precuneus), without a corresponding disruption of functional or graph theoretical properties. However, functional and graph theoretical changes appeared in salience network nodes, without evidence of gray matter loss. Global cognition and executive scores showed a correlation with node degree in the right anterior insula. We also found a correlation between visuospatial scores and right supramarginal gyrus node degree. Our findings highlight the loss of functional connectivity and topological features without structural damage in salience network regions in PD-MCI. They also underline the importance of multimodal hubs in the transition to mild cognitive impairment. This functional disruption in the absence of gray matter atrophy suggests that the salience network is a key vulnerable system at the onset of mild cognitive impairment in PD.
OBJECTIVES: To test the heterogeneity of the effect of a change in pharmaceutical cost-sharing by therapeutic groups in a Spanish region. METHODS: Data: random sample (provided by the Canary Islands Health Service) of 40,471 people covered by the Spanish National Health System (SNHS) in the Canary Islands. The database includes individualised monthly-dispensed medications (prescribed by the SNHS) from one year before (August 2011) to one year after (June 2013) the Royal Decree Law 16/2012 (RDL 16/2012). Sample: two intervention groups (low-income pensioners and middle-income working population) and one control group (low-income working population). Empirical model: quasi-experimental difference-in-differences design to study the change in consumption (measured in number of monthly Defined Daily Dose (DDDs) per individual) among 13 therapeutic groups. The policy break indicator (three-level categorical variable) tested the existence of stockpiling between the reform's announcement and its implementation. We ran 16 linear regression models (general, by therapeutic groups and by comorbidities) that considered whether the exclusion of some drugs from public provision impacted on consumption more than the co-payment increase. RESULTS: General: Reduction (-13.04) in consumption after the reform's implementation, which was fully compensated by a previous increase (16.60 i.e., stockpiling) among low-income pensioners. The middle-income working population maintained its trend of increasing consumption. Therapeutic groups: Reductions in consumption after the reform's implementation among low-income pensioners in 7 of the 13 groups, which were fully compensated for by a previous increase (i.e., stockpiling) in 4 groups and partially compensated for in the remaining 3. The analysis without the excluded medicines provided fewer negative coefficients. Comorbidities: Reduction in consumption that was only slightly compensated for by a previous increase (i.e., stockpiling). CONCLUSIONS: The negative impact of cost-sharing produced, among low-income pensioners, a risk of loss of adherence to treatments, which could deteriorate the health status of individuals, especially among pensioners within the most inelastic therapeutic groups (associated with chronic diseases) and patients with comorbidities (also, associated with chronic diseases). Notwithstanding the above, this risk was more related to the exclusion of some drugs from provision than to the cost-sharing increase.
AssuntosDedutíveis e Cosseguros , Custos de Medicamentos , Medicamentos sob Prescrição/economia , Dedutíveis e Cosseguros/legislação & jurisprudência , Dedutíveis e Cosseguros/estatística & dados numéricos , Dedutíveis e Cosseguros/tendências , Custos de Medicamentos/legislação & jurisprudência , Custos de Medicamentos/estatística & dados numéricos , Custos de Medicamentos/tendências , Feminino , Humanos , Modelos Lineares , Masculino , Programas Nacionais de Saúde/economia , Programas Nacionais de Saúde/legislação & jurisprudência , Programas Nacionais de Saúde/estatística & dados numéricos , Cooperação do Paciente/estatística & dados numéricos , Pobreza/economia , Pobreza/estatística & dados numéricos , Medicamentos sob Prescrição/provisão & distribução , Espanha
BACKGROUND: Minor hallucinations and well-structured hallucinations are considered in the severity continuum of the psychotic spectrum associated with Parkinson's disease. Although their chronological relationship is largely unknown, the spatial patterns of brain atrophy in these 2 forms of hallucinations partially overlap, suggesting they share similar pathophysiological processes. Functional connectivity studies show that disruption of functional networks involved in perception and attention could be relevant in the emergence of well-structured hallucinations. However, functional neuroimaging studies in patients with isolated minor hallucinations are lacking. The objectives of this study were to explore the structural and functional changes underlying minor hallucinations. METHODS: We compared patients with (n = 18) and without (n = 14) minor hallucinations using a multimodal structural (gray-matter volume voxel-based morphometry) and functional (seed-to-whole-brain resting-state functional MRI) neuroimaging study. RESULTS: Coincident with previously described structural changes in well-structured hallucinations in Parkinson's disease, patients with minor hallucinations exhibited gray-matter atrophy with significant voxel-wise differences in visuoperceptual processing areas and core regions of the default mode network. Functional connectivity changes consisted of altered connectivity within the default mode network, reduced negative correlation with task-positive network, and aberrant connectivity between posterior regions of the default mode network and visual-processing areas. These changes are in accordance with the attentional networks hypothesis proposed for well-structured hallucinations. CONCLUSIONS: Although longitudinal studies are needed to assess the potential role of minor hallucinations as an early clinical biomarker of progression to well-structured hallucinations, the present findings show that the 2 phenomena share similar structural and functional brain correlates. © 2018 International Parkinson and Movement Disorder Society.
AssuntosAtenção/fisiologia , Encéfalo/fisiopatologia , Rede Nervosa/fisiopatologia , Doença de Parkinson/fisiopatologia , Idoso , Encéfalo/patologia , Mapeamento Encefálico/métodos , Transtornos Cognitivos/fisiopatologia , Feminino , Humanos , Processamento de Imagem Assistida por Computador/métodos , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos
BACKGROUND: Adult IDH-wildtype astrocytomas with TERT promoter mutations (TERTp) are associated with a poor prognosis. OBJECTIVE: To analyze the radiological presentation and natural history of adult IDH-wildtype astrocytomas with TERTp. METHODS: We retrospectively reviewed the characteristics of 40 IDH-wildtype TERTp-mutant astrocytomas (grade II n = 19, grade III n = 21) and compared them to those of 114 IDH-mutant lower grade gliomas (LGG), of 92 IDH-wildtype TERTp-mutant glioblastomas, and of 15 IDH-wildtype TERTp-wildtype astrocytomas. RESULTS: Most cases of IDH-wildtype TERTp-mutant astrocytomas occurred in patients aged >50 yr (88%) and presented as infiltrative lesions without contrast enhancement (73%) that were localized in the temporal and/or insular lobes (37.5%) or corresponded to a gliomatosis cerebri (43%). Thalamic involvement (33%) and extension to the brainstem (27%) were frequently observed, as was gyriform infiltration (33%). This radiological presentation was different from that of IDH-mutant LGG, IDH-wildtype TERTp-mutant glioblastomas, and IDH-wildtype TERTp-wildtype astrocytomas. Tumor evolution before treatment initiation was assessable in 17 cases. Ten cases demonstrated a rapid growth characterized by the apparition of a ring-like contrast enhancement and/or a median velocity of diametric expansion (VDE) ≥8 mm/yr but 7 cases displayed a slow growth (VDE <8 mm/yr) that could last several years before anaplastic transformation. Median overall survival of IDH-wildtype TERTp-mutant astrocytomas was 27 mo. CONCLUSION: IDH-wildtype TERTp-mutant astrocytomas typically present as nonenhancing temporo-insular infiltrative lesions or as gliomatosis cerebri in patients aged >50 yr. In the absence of treatment, although rapid tumor growth is frequent, an initial falsely reassuring, slow growth can be observed.
BACKGROUND: Oxaliplatin (OXA) is a cornerstone in the treatment of colorectal cancer (CRC). Retreatment with OXA is frequently considered as salvage treatment. OXA-induced neuropathy (OIN) is the most frequent and feared long-term side effect. PATIENTS AND METHODS: CRC patients receiving at least twice OXA-based chemotherapy lines at our institution between June 2000 and July 2016 were reviewed. The aim of this study was to investigate whether retreatment with OXA increases the risk of developing new or worsening previous neuropathy. OIN was assessed by National Cancer Institute-Common Toxicity Criteria for Adverse Events (NCI), Total Neuropathy Score© (TNS) and nerve-conduction studies. RESULTS: 106 patients were included in the analysis. Median age at OXA-based retreatment was 61.5 (20-83) years. After the first OXA-based chemotherapy treatment, 63.4% of patients developed OIN, 30.7 and 8.9% grades 2 and 3, respectively, after a median of 11 (1-17) cycles. After 30 (11-90) months of median to retreatment with a median of 8 (1-14) OXA cycles, 39.6, 22.6, and 0% of patients developed grade 1, 2, and 3 OIN, respectively. Worsening of the previous OIN was observed in one-third (31.1%) of all patients. OXA-cumulative dose was independently associated with greater risk of worsening OIN (p < 0.001). Non-significant trend towards higher TNSc© scores after retreatment was observed [5 (0-11) vs 6 (3-13), p = 0.083]. CONCLUSION: Retreatment with OXA in CRC patients is a feasible option even in patients who previously developed moderate or severe OIN. One-third of patients' OIN was worsened by retreatment. Neurological monitoring should be considered.
AssuntosAntineoplásicos/efeitos adversos , Neoplasias Colorretais/tratamento farmacológico , Compostos Organoplatínicos/efeitos adversos , Compostos Organoplatínicos/uso terapêutico , Doenças do Sistema Nervoso Periférico/induzido quimicamente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Oxaliplatina , Adulto Jovem
Type 1 diabetes can be overcome by regulatory T cells (Treg) in NOD mice yet an efficient method to generate and maintain antigen-specific Treg is difficult to come by. Here, we devised a combination therapy of peptide/MHC tetramers and IL-2/anti-IL-2 monoclonal antibody complexes to generate antigen-specific Treg and maintain them over extended time periods. We first optimized treatment protocols conceived to obtain an improved islet-specific Treg/effector T cell ratio that led to the in vivo expansion and activation of these Treg as well as to an improved suppressor function. Optimized protocols were applied to treatment for testing diabetes prevention in NOD mice as well as in an accelerated T cell transfer model of T1D. The combined treatment led to robust protection against diabetes, and in the NOD model, to a close to complete prevention of insulitis. Treatment was accompanied with increased secretion of IL-10, detectable in total splenocytes and in Foxp3- CD4 T cells. Our data suggest that a dual protection mechanism takes place by the collaboration of Foxp3+ and Foxp3- regulatory cells. We conclude that antigen-specific Treg are an important target to improve current clinical interventions against this disease.
AssuntosAnticorpos Monoclonais/imunologia , Diabetes Mellitus Tipo 1/imunologia , Diabetes Mellitus Tipo 1/terapia , Antígenos de Histocompatibilidade/química , Interleucina-2/imunologia , Peptídeos/química , Linfócitos T Reguladores/imunologia , Sequência de Aminoácidos , Animais , Diabetes Mellitus Tipo 1/tratamento farmacológico , Feminino , Camundongos , Peptídeos/farmacologia , Fenótipo , Multimerização Proteica , Estrutura Quaternária de Proteína , Linfócitos T Reguladores/efeitos dos fármacos
The direct dialkylation of triazolo[4,3-b]isoquinolin-3-ylidene structures readily affords dicationic N-heterotricyclic azolium salts. These are suitable starting materials for the synthesis of transition metal complexes containing N-heterotricyclic, cationic ligands characterized by extended charge delocalization. Silver and gold complexes as well as mono- and dicationic rhodium(i) complexes have been prepared and characterized, and the electronic properties of the ligand have been evaluated by using the TEP parameter and by comparison with a non-cationic analogue. X-Ray diffraction analysis of several carbene-metal complexes shows a negligible effect of the charge on the structures of the complexes. The catalytic activity of a tricationic gold complex has been evaluated in the intramolecular hydroarylation of a terminal alkyne.
OBJECTIVE: To identify the clinical and radiological features that should raise suspicion for the autoimmune encephalitis (AE)-like presentation of glioblastoma. METHODS: This is an observational, retrospective case series of patients referred to the French National Reference Center on Paraneoplastic Neurological Diseases for suspected AE (possible, probable or definite, using the 2016 criteria) who later received a final diagnosis of glioblastoma according to 2016 WHO criteria. An extensive literature search was also conducted for similar existing cases. RESULTS: Between 2014 and 2016, 306 patients were referred to our center for suspected AE. Six of these patients (2%) later developed pathologically confirmed glioblastoma. Thirteen patients (9 male) were included for analysis (6 from the present series and 7 from the literature); median age was 63. Initially, a diagnosis of AE was clinically suspected based on: working memory deficits (77%), seizures (62%) (including status epilepticus in 23%), and psychiatric symptoms (46%). Initial brain MRI was not in favor of a typical glioblastoma pattern and showed bilateral (54%) or unilateral selective limbic involvement. Five patients exhibited initial slight contrast enhancement. A clear inflammatory CSF was present in five patients and three from the literature showed autoantibody positivity (NMDAR, VGKC, GluRepsilon2). Median delay between suspicions of AE to GBM diagnosis was 3 months (range 1.5-24) and one patient from the literature was diagnosed post-mortem. CONCLUSIONS: An alternative diagnosis of glioblastoma should be considered in patients presenting initially as AE, especially in patients who do not fulfill the criteria for definite AE and in those with a poor clinical evolution despite initial improvement.
AssuntosNeoplasias Encefálicas/diagnóstico , Encefalite/diagnóstico , Glioblastoma/diagnóstico , Doença de Hashimoto/diagnóstico , Adulto , Idoso , Biomarcadores/líquido cefalorraquidiano , Encéfalo/diagnóstico por imagem , Encéfalo/patologia , Neoplasias Encefálicas/patologia , Neoplasias Encefálicas/terapia , Diagnóstico Diferencial , Encefalite/terapia , Feminino , Glioblastoma/patologia , Glioblastoma/terapia , Doença de Hashimoto/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
Rechallenge with temozolomide has been shown to be a valid option in selected patients with progressive glioblastoma. Herein, we assessed the efficacy of rechallenge with bevacizumab in glioblastoma patients progressing off therapy. We retrospectively identified and analyzed the characteristics of patients with glioblastoma rechallenged with a bevacizumab-based chemotherapy regimen after having received bevacizumab as first-line treatment in association with temozolomide radiochemotherapy or at recurrence in association with temozolomide, CCNU or irinotecan. Twenty-five patients were identified. In all included patients, the first bevacizumab treatment resulted in an objective response and was discontinued for reasons other than disease progression (adverse event n = 9, physician or patient decision n = 16). Median duration of first bevacizumab treatment was 6 months (range: 2-58 months). None of the patients presented a rebound effect after bevacizumab discontinuation. The median interval between discontinuation of first bevacizumab treatment and bevacizumab rechallenge was 8.9 months (range: 2-58 months). At this time, bevacizumab was given in association with lomustine (n = 17), temozolomide (n = 6), irinotecan (n = 1), or alone (n = 1). Bevacizumab rechallenge resulted in an objective response in 15 patients (60%). Median progression-free survival was 6.7 months and overall survival was 9.6 months after bevacizumab rechallenge. Timing of first bevacizumab treatment (as first-line treatment or at recurrence) was not associated with the duration of response after treatment rechallenge. In the present series, patients who responded to bevacizumab and in whom this treatment was discontinued in the absence of tumor progression seemed to benefit from rechallenge with a bevacizumab-based chemotherapy regimen.
AssuntosAntineoplásicos Imunológicos/uso terapêutico , Bevacizumab/uso terapêutico , Neoplasias Encefálicas/tratamento farmacológico , Glioblastoma/tratamento farmacológico , Idoso , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/genética , Progressão da Doença , Feminino , Seguimentos , Glioblastoma/diagnóstico por imagem , Glioblastoma/genética , Humanos , Isocitrato Desidrogenase/genética , Estimativa de Kaplan-Meier , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Mutação/genética , Intervalo Livre de Progressão , Estudos Retrospectivos , Resultado do Tratamento
Pungent chemical compounds originating from decaying tissue are strong drivers of animal behavior. Two of the best-characterized death smell components are putrescine (PUT) and cadaverine (CAD), foul-smelling molecules produced by decarboxylation of amino acids during decomposition. These volatile polyamines act as 'necromones', triggering avoidance or attractive responses, which are fundamental for the survival of a wide range of species. The few studies that have attempted to identify the cognate receptors for these molecules have suggested the involvement of the seven-helix trace amine-associated receptors (TAARs), localized in the olfactory epithelium. However, very little is known about the precise chemosensory receptors that sense these compounds in the majority of organisms and the molecular basis of their interactions. In this work, we have used computational strategies to characterize the binding between PUT and CAD with the TAAR6 and TAAR8 human receptors. Sequence analysis, homology modeling, docking and molecular dynamics studies suggest a tandem of negatively charged aspartates in the binding pocket of these receptors which are likely to be involved in the recognition of these small biogenic diamines.
AssuntosCadaverina/química , Diaminas/química , Putrescina/química , Olfato , Animais , Ácido Aspártico/química , Comportamento Animal , Proteínas de Ciclo Celular/química , Biologia Computacional , Simulação por Computador , Humanos , Ligantes , Simulação de Acoplamento Molecular , Proteínas Nucleares/química , Mucosa Olfatória/fisiologia , Filogenia , Poliaminas/química , Ligação Proteica , Receptores Acoplados a Proteínas-G/química , Peixe-Zebra
BACKGROUND: Previous studies have reported an association between maternal zinc deficiency and increased risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) in offspring. A high prevalence of zinc deficiency and a high prevalence of NSCL/P have been reported in Ecuador. We postulated that mothers of infants with NSCL/P may have lower serum zinc levels than women from the general population. METHODS: A case series study was conducted from November 2013 to July 2016. Thirty-five healthy mothers of infants with NSCL/P were selected during surgical missions conducted by Operación Sonrisa Ecuador. A single blood sample along with pertinent medical history was collected during personal interviews after 3.6 months postpartum. The prevalence of plasma zinc concentration (PZn) deficiency among the participants was determined and analyzed along with the prevalence of PZn deficiency in Ecuadorian women of reproductive age from the general population. RESULTS: The mean PZn was 11.47 µmol/dm3 . The prevalence of PZn deficiency among the participants was 31.4% (95% CI: 17.1-48.6) and differed significantly from the prevalence of zinc deficiency observed among women from the general population (G2 = 8.66; p < .05). CONCLUSIONS: The results showed that the prevalence of PZn deficiency is lower in a cohort of healthy mothers of infants with NSCL/P than in women from the general population in Ecuador. More studies are required to confirm these findings and evaluate other factors related to NSCL/P pathophysiology in the Ecuadorian population.
AssuntosFenda Labial/sangue , Fissura Palatina/sangue , Mães , Zinco/sangue , Equador , Feminino , Humanos , Lactente , Masculino , Adulto Jovem
PURPOSE OF REVIEW: The current review summarizes recent advances on the oncogenesis, classification and treatment of adult anaplastic gliomas. RECENT FINDINGS: According to the 2016 WHO classification, three main molecular subgroups of adult diffuse anaplastic gliomas can be distinguished based on the 1p/19q codeletion and isocitrate dehydrogenase (IDH) mutation status. In the future, this classification may be further refined based on the telomerase reverse transcriptase promoter and alpha thalassemia/mental retardation syndrome X-linked mutation status, gene expression, DNA methylation and genomic profiling. Both newly diagnosed 1p/19q codeleted and 1p/19q-intact anaplastic gliomas benefit from the addition of chemotherapy to radiotherapy. However, in 1p/19q codeleted anaplastic gliomas, Procarbazine, CCNU and Vincristine chemotherapy seems more effective than temozolomide. At recurrence, 1p/19q-intact anaplastic gliomas do not benefit from the addition of bevacizumab to temozolomide. The use of poly(adenosine 5'-diphosphate-ribose) inhibitors may be another way of specifically targeting IDH-mutant gliomas in addition to specific inhibitors, demethylating agents and anti-IDH vaccines. v-raf murine sarcoma viral oncogene homolog B1 (BRAF)-mutant anaplastic xanthoastrocytomas and gangliogliomas may benefit from BRAF and mitogen-activated protein kinase inhibitors. SUMMARY: Molecular characterization is mandatory for integrated diagnosis and appropriate management of adult anaplastic gliomas. Both 1p/19q codeleted and 1p/19q-intact anaplastic diffuse gliomas benefit from early chemotherapy. At recurrence, preliminary data suggest a potential role for targeted therapies in specific molecular subgroups.
AssuntosNeoplasias Encefálicas/classificação , Neoplasias Encefálicas/terapia , Glioma/classificação , Glioma/terapia , Adulto , Neoplasias Encefálicas/genética , Deleção Cromossômica , Cromossomos Humanos Par 1 , Cromossomos Humanos Par 19 , Glioma/genética , Humanos
Objetivos: Determinar el nivel de ruido producido durante los procedimientos clínicos odontológicos en las Áreas de Operatoria dental, Prótesis fija, Endodoncia y Odontopediatría de la Facultad de Odontología de la Universidad Nacional Mayor de San Marcos, Centro Médico Naval y Hospital Nacional Hipólito Unanue. Material y métodos: Se tomó una muestra por conveniencia de 80 registros sonoros de procedimientos clínicos odontológicos en prótesis fija, operatoria dental, odontopediatría y endodoncia usando un sonómetro digital, el cual fue colocado a nivel del oído y a una distancia de 45 cm del procedimiento clínico odontológico. Resultados: Se encontró que el mayor promedio de nivel de ruido a la altura del oído fue en operatoria dental con 83,13 decibeles(dB) y el menor fue en endodoncia con 65,57 dB. A 45 cms., el mayor promedio fue en prótesis fija con 76,99 dB y el menor fue en Endodoncia con 61,62 dB. Conclusiones: Los procedimientos clínicos odontológicos de operatoria dental, prótesis fija, endodoncia y odontopediatría se encontraron dentro de los límites permisibles sonoros del Ministerio de Salud del Perú.
Objetives: to determine the noise level made during odontological clinical procedures at the areas of operative dentistry, fixed prosthetics, endodontics and pediatric dentistry, at the Faculty of Dentistry at San Marcos University, Navy Medical Center and Hipolito Unanue National Hospital. Material and methods:A convenience sample of 80 sound records were registered at Dental Operatory, Fixed Prosthetic, Endodoncy, and Pediatric Dentistry clinics using a digital sound meter, which were located at ear level and at 45cm from the clinical dental procedure. Results: The highest average noise record at ear level was 83.13 decibels (dB) at dental operatory, and the lowest average noise record was 65.57 dB at endodoncy. The highest average noise record at 45 cm from de clinical dental procedure was 76.99 dB at Fixed Prosthetics, and the lowest average noise record was 61.62 dB at endodoncy. Conclusions: The sound level of dental operatory, fixed prosthetic, endodoncy, and pediatric dentistry were within the permissible limits by the Health Ministry of Peru.
The benzoannulation of the most common families of aromatic NHCs, imidazol-2-ylidenes and 1,2,4-triazol-3-ylidenes, results in heterobicyclic imidazo[1,5-a]pyridin-3-ylidenes ('s) and [1,2,4]triazolo[4,3-a]pyridin-3-ylidenes ('s), characterized by a bridged N atom. These are versatile platforms that offer multiple possibilities for the modulation of the steric and electronic properties of the carbene ligand and/or organocatalyst, and offer also diverse opportunities for the introduction of several types of chiralities. In this paper the different families of chiral and carbenes and their application in asymmetric catalysis will be discussed.
Regulatory T cells hold promise as targets for therapeutic intervention in autoimmunity, but approaches capable of expanding antigen-specific regulatory T cells in vivo are currently not available. Here we show that systemic delivery of nanoparticles coated with autoimmune-disease-relevant peptides bound to major histocompatibility complex class II (pMHCII) molecules triggers the generation and expansion of antigen-specific regulatory CD4(+) T cell type 1 (TR1)-like cells in different mouse models, including mice humanized with lymphocytes from patients, leading to resolution of established autoimmune phenomena. Ten pMHCII-based nanomedicines show similar biological effects, regardless of genetic background, prevalence of the cognate T-cell population or MHC restriction. These nanomedicines promote the differentiation of disease-primed autoreactive T cells into TR1-like cells, which in turn suppress autoantigen-loaded antigen-presenting cells and drive the differentiation of cognate B cells into disease-suppressing regulatory B cells, without compromising systemic immunity. pMHCII-based nanomedicines thus represent a new class of drugs, potentially useful for treating a broad spectrum of autoimmune conditions in a disease-specific manner.
AssuntosAutoantígenos/imunologia , Autoimunidade/imunologia , Linfócitos T Reguladores/imunologia , Animais , Células Apresentadoras de Antígenos/imunologia , Linfócitos B/citologia , Linfócitos B/imunologia , Antígenos CD11/imunologia , Diferenciação Celular , Citocinas/imunologia , Feminino , Antígenos de Histocompatibilidade Classe II/química , Antígenos de Histocompatibilidade Classe II/genética , Antígenos de Histocompatibilidade Classe II/imunologia , Humanos , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos NOD , Camundongos Transgênicos , Nanomedicina , Nanopartículas/química , Nanopartículas/uso terapêutico , Especificidade de Órgãos , Prevalência , Solubilidade , Linfócitos T Reguladores/citologia
Objectives: To evaluate the level of concordance between the 2007 PRETEMED guidelines and the 2012 American College of Chest Physicians (ACCP) guidelines in medical patients at admission. Methods: A cross-sectional, observational and descriptive study was designed and included all adult medical patients admitted from an emergency department. Firstly, patients classified as low-moderate risk and high risk according to PRETEMED were compared to those classified by ACCP as low and high risk. Secondly, the same analysis was performed but this time low and moderate-high risk patients according to PRETEMED were compared to ACCP low and high risk patients. The level of concordance was calculated using the kappa concordance index. The study was approved by the Ethics Committee for Clinical Research of the hospital. Results: The analysis was performed with 207 patients; 53.1% were male and the median age was 75.3 years (minimum 18, maximum 100â years old). The most common diagnosis at admission was related to a respiratory disease (37.2%). The level of concordance was 0.59 (95% CI 0.48 to 0.70) when moderate risk patients were grouped with low-risk patients and 0.53 (95% CI 0.42 to 0.65) when moderate risk patients were grouped with high-risk patients. Conclusions: The level of concordance between both guides is moderate. It would be helpful to confirm whether the level of agreement improves when the patient's condition stabilises after several days of hospitalisation.
BACKGROUND: Primary central nervous system lymphomas may present as diffuse, nonenhancing infiltrative lesions. This rare variant is termed lymphomatosis cerebri (LC). We did a systematic review and analysis of the literature, adding our own cases, to better characterize LC in order to improve early diagnosis and treatment. METHODS: PubMed, ISI Web of Knowledge, and hospital databases were reviewed. Information was extracted regarding demographic, clinical, histological, cerebrospinal fluid (CSF), neuroimaging, and treatment variables. The impact of single parameters on overall survival (OS) was determined by applying univariate and multivariate analyses. RESULTS: Forty-two patients were included (median age: 58 y; range: 28-80 y). At consultation, 52% of patients had a poor KPS. The most common presenting symptom was cognitive decline (59.5%). Imaging studies showed supratentorial and infratentorial infiltration in 55% of patients and bilateral hemispheric involvement in 95%. CSF pleocytosis was present in 51.5% of the patients. Median time to diagnosis was 4.5 (range: 1-30) months, and the diagnosis was not established until autopsy for 33% of patients. The median OS was 2.95 (range: 0.33-56) months; however, those patients who received methotrexate had a median OS of 13.8 (range: 0.7-56) months. Analysis identified KPS ≥ 70 (HR: 0.32; 95% CI: 0.114-0.894; P = .03) and treatment with methotrexate (HR: 0.19; 95% CI: 0.041-0.886; P = .034) as independent favorable prognostic factors, whereas T-cell lymphoma was independently related with a worse outcome (HR: 6.62; 95% CI: 1.317-33.316; P = .022). CONCLUSIONS: LC is a misdiagnosed entity associated with considerable diagnostic delay. MRI evidence of bilateral hemispheric involvement and CSF pleocytosis should be alerts for this diagnosis. Treatment with methotrexate-based chemotherapy must be considered, especially for patients with good KPS.
AssuntosNeoplasias do Sistema Nervoso Central/patologia , Linfoma/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Antineoplásicos/uso terapêutico , Neoplasias do Sistema Nervoso Central/mortalidade , Neoplasias do Sistema Nervoso Central/terapia , Feminino , Humanos , Estimativa de Kaplan-Meier , Linfoma/mortalidade , Linfoma/terapia , Masculino , Pessoa de Meia-Idade , Radioterapia
The first asymmetric cycloaddition of nonstabilized azomethine ylide and N-sulfinylimines is presented. In reactions with aryl-alkyl and heteroaryl-alkyl ketimines, excellent diastereoselectivities and good yields are obtained in all cases, regardless of the electronic character of the substituents at the aromatic rings. Moreover, the cycloadducts obtained can easily be deprotected in acid media, giving access to free 1,2-diamines which are prevalent in many natural and pharmaceutical products.


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Albuquerque, NM (February 19, 2020) – Officers with the Albuquerque Police Department responded to a fatal car accident that took place on Monday, February 17th, according to authorities. The deadly crash was reported at the intersection of 2nd Street and Constitution Avenue.
The drivers of a Nissan and an Infinity were reported to have collided at the intersection. Emergency crews arrived at the scene where the driver of the Nissan was sadly pronounced deceased. The other driver was treated for injuries at the scene but there has been no word on their current condition.
Police have not released the identities of those involved as no further details were provided. The official cause of the incident remains under investigation.
We would like to offer our deepest condolences to the family of the deceased victim at this time. Our thoughts are with the injured victim and their family in hopes of a full recovery.
Fatal Car Accidents in New Mexico
About 29 percent of all car crashes that happened across New Mexico during 2017 were found to have ended with at least some form of injury, according to researchers. Approximately 1 percent of those reported collisions tragically resulted in at least one death per occurrence. While the likelihood of suffering an injury might be higher than the risk of death, sustaining an unexpected injury of nearly any kind in a New Mexico car accident can be shocking and overwhelming, nonetheless.
Being injured in an accident of any kind can be a very frightening, confusing, and overwhelming time in a person's life. That is why we have worked to compile the most pertinent information and invaluable resources to aid victims who have been injured in an accident that was caused by another person or entity's careless, reckless, negligent, or deliberate actions. One of the local attorneys in your area has offered to provide you with a copy of your police accident report at no cost to you. Contact us today to get your complimentary accident report.
If you have a question that you were not able to find on the Local Accident Reports website, contact us today and we will put you in contact with a skilled personal injury lawyer in your area who will be able to provide you with answers to all of your questions. Contact Local Accident Reports today at 1-888-657-1460.
Note: These posts are created solely for the use of Local Accident Reports. We have not verified the information in these posts as the information is gathered from secondary sources. If you have personal knowledge that the information contained in these posts is inaccurate, please contact Local Accident Reports immediately so we can make the necessary corrections or remove the story.
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Nichols Crowder is pleased to offer to the market this major Commercial 1 landholding with a permit located in one of Victoria's fastest growing corridors, Hampton Park.
Key features include:
* Major landholding of 13,000sqm*
* Permit for mixed use project
* Located in the heart of the retail centre of Hampton Park
* Impressive exposure to Hallam Road of 113.6m* with additional road frontages
* Plentiful development opportunities, ranging from large scale commercial to a mixed use site
* Site has already been cleared & is ready for construction
* Hampton Park Central trade area services over 42,000 residents & workers
For further information or to arrange an inspection, please contact:
Mary O'Halloran - 0418 323 420
Renato Daniele - 0414 733 500
NB: All areas and measurements are approximate. All prices are plus GST, unless otherwise stated. All images and renders are subject to copyright.
*Denotes Approx.
For more details, please email agent


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At one point, the US Government actually owned the largest amount of bitcoin in a single wallet with 144,341 bitcoin in it.
Bitcoin - The Currency of the Internet • March 6, 2020, 6:32 pm
submitted by /u/Mongo91 [link] [comments]
CoinDesk • March 6, 2020, 11:31 am
Bitcoin is printing gains amid coronavirus-led risk aversion in the traditional markets.
CoinDesk • March 5, 2020, 9:30 pm
South Korean lawmakers voted to place tough new requirements on cryptocurrency exchanges, adding legitimacy to the country's sprawling crypto economy – and potentially triggering a market…
Crypto New Media • March 6, 2020, 9:45 pm
Crypto New Media Press Bitcoin price surges above $9,000 but fails to break both the channel and $9,200 resistance. BTC/USD remains in the hands of the bulls above $9,000 but must rise above $9,200…
Crypto New Media • March 6, 2020, 9:47 pm
Crypto New Media Press The Crown Jewels Many people get confused between Price & Value. One of the best metaphoric examples to illustrate the difference is the Crown Jewels. The Crown Jewels are…


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Which Kung Fu Panda movie character are you?
Is Kung Fu Panda your favorite movie? Can you relate to characters of Kung Fu Panda? Do you think that you can be one of those in the movie? Ok, which Kung Fu Panda character are you? Take the quiz below to know more on this.
1. Do you think you have the will to face anything what comes at you?
Please answer this question.
Maybe, this is true
Yeah! You have
Well, sort of true
Depends on the situation
2. How are you as a person?
Please answer this question.
You can say intelligent
You are different
Maybe kind hearted
You can be secretive
3. What is your most favorite color?
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Its color pink
You like the color black
Its the color white
Hmm..its blue
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You like to listen to music
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Its your mind
Its your nature
Maybe your dark secrets
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9. Would you fight for your own rights, be honest?
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Depends on the situation
You would
Maybe yes..it depends
You are not too sure
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Click to send email to John Pieters, CPA.
Specialties: Small business and personal taxation and consulting; payroll taxes; financial statement presentation and evaluation; small business retirement plan consulting
Bio: John originally is from Michigan and received his B.A. in accounting from Michigan State University. Upon graduation, he worked in the audit department for Ernst and Young, LLP in Detroit, Michigan, and received his CPA certification. John moved to San Diego in 1998 and worked for Science Applications International Corporation (SAIC) in the corporate financial reporting group. He left SAIC to join inCode Telecom Group, a San Diego-based telecommunications start-up company, where he was responsible for operational accounting and financial statement reporting. In 2003, John began working with Jeanne Max and was promoted to a principal in the firm in 2008.
John is a member of the American Institute of Certified Public Accountants and the California Society of Certified Public Accountants. He currently provides seminars to several local organizations regarding individual and business tax concepts and is active in the San Diego Meals-on-Wheels organization.
In his spare time, John enjoys playing sports, traveling with his wife Julie and sons Henry and Samuel, and rooting for the Michigan State football and basketball teams. Go Green!
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Residency Certificate in Spain in Turin
My training path as a criminal lawyer unfolds through either domestic or comparative and international law, through both academic and professional experiences. Among the former, following the graduation in Law at the University of Turin with a comparative thesis on the issue of mental capacity in Civil Law and Common Law systems, I completed a Master of Laws (LL.M) at the United Nations Interregional Crime and Justice Research Institute with a final thesis on the comparative criminal procedure, postgraduate courses at the Academy of Public and Private International Law of The Hague and made research as Assistant Professor at Turin University for the International Law and International Organisations course. I qualified as a Lawyer and became a member of Turin Bar Association in 2009. In 2014 I qualified as Solicitor for the Senior Courts of England and Wales and therefore I became a member of the Solicitors Regulation Authority and of the Law Society of London. Among professional experiences in 2007 I had the unique opportunity to take active part to the trial of the Khmer Rouge regime leaders ongoing before the Extraordinary Chambers in the Courts of Cambodia, being a member of the Co-Prosecutors'Office at the UNAKRT (United Nations Assistance to Khmer Rouge Trial). The year after I became a counsel for the United Nations Interregional Crime and Justice Research Institute (UNICRI) in Turin. After several enriching international experiences I settled in Turin, where I work as a qualified lawyer. I am associate to the law firm VBSM_Vinai-Bonatti-Sattanino-Maldera, dealing mainly with criminal law and company law with the consequent international implications (I am also a member of PEOPIL – Pan European Organisation of Personal Injury Lawyers). I therefore also work on damage compensation issues for personal injuries and the protection of the compensatory interests of victims of major trauma, road traffic accidents, workplace accidents, occupational diseases and medical malpractice either from a compensatory or from a criminal point of view.
Residency Certificate in Spain
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Página 108 - Why hast thou then broken down her hedges, so that all they which pass by the way do pluck her? The boar out of the wood doth waste it, and the wild beast of the field doth devour it.
Página 22 - All our conduct towards men should be influenced by this important precept " Do unto others as you would that others should do unto you.
Página 112 - Alas, poor Yorick! I knew him, Horatio; a fellow of infinite jest, of most excellent fancy. He hath borne me on his back a thousand times. And now how abhorred in my imagination it is! My gorge rises at it. Here hung those lips that I have kissed I know not how oft.
Página 51 - A brute arrives at a point of perfection that he can never pass : in a few years he has all the endowments he is capable of; and were he to live ten thousand more, would be the same thing he is at present.
Página 66 - Ten censure wrong for one who writes amiss ; A fool might once himself alone expose, Now one in verse makes many more in prose.
Página 113 - And I will make thy seed as the dust of the earth : so that if a man can number the dust of the earth, then shall thy seed also be numbered.
Página 34 - I will put my hook in thy nose, and my bridle in thy lips, and I will turn thee back by the way by which thou earnest.
Página 72 - mongst other matter, Of the Chameleon's form and nature. ' A stranger animal,' cries one, ' Sure never lived beneath the sun : A lizard's body lean and long, A fish's head, a serpent's tongue, Its foot with triple claw disjoined ; And what a length of tail behind ! How slow its pace ! and then its hue — Who ever saw so fine a blue?"
Página 11 - The Lord of all, himself through all diffused, Sustains, and is the life of all that lives. Nature is but a name for an effect, Whose cause is God.
Página 112 - I cannot but imagine the virtuous heroes, legislators, and patriots, of every age and country, are bending from their elevated seats to witness this contest, as if they were incapable, till it be brought to a favourable issue, of enjoying their eternal repose. Enjoy that repose, illustrious immortals...