text:
Principal Proposed Uses
Huperzine A (HUP-er-zeen) is a potent chemical derived from a particular type of club moss ( Huperzia serrata [Thumb] Trev.). Like caffeine and cocaine, huperzine A is a medicinally active, plant-derived chemical that belongs to the class known as alkaloids. It was first isolated in 1948 by Chinese scientists. 1 This substance is really more a drug than an herb, but it is sold over the counter as a dietary supplement for memory loss and mental impairment.
Studies in animals suggested that it could improve memory skills. 2-17 These finding led to human trials (described below) and the subsequent marketing of the huperzine A as a treatment for Alzheimer's disease and related conditions. It is also sold as a "brain booster" for enhancing memory and mental function in people without Alzheimer's disease.
Huperzine A inhibits the enzyme acetylcholinesterase (uh-SEE-tul-co-lin-ES-ter-ase). This enzyme breaks down acetylcholine, a substance that plays an important role in mental function. When the enzyme that breaks it down is inhibited, acetylcholine levels in the brain tend to rise. Drugs that inhibit acetylcholinesterase (such as tacrine and donepezil) improve memory and mental functioning in people with Alzheimer's and other severe conditions. The research on huperzine A indicates that it works in much the same way. The chemical action of huperzine A is very precise and specific. It "fits" into a niche on the enzyme where acetylcholine is supposed to attach. 22,23 Because huperzine A is in the way, the enzyme cannot grab and destroy acetylcholine. This mechanism has been demonstrated by considerable scientific work, including sophisticated computer modeling of the shape of the molecule. 24 Huperzine may also help protect nerve cells from damage. 25-28
Note that, while huperzine A is sold as a dietary supplement, in all essential ways it is simply a typical drug. Huperzine A is highly purified in a laboratory and is just a single chemical. It is simply not much like an herb. Herbs contain hundreds or thousands of chemicals. Huperzine A resembles drugs such as digoxin, codeine, Sudafed, and vincristine (a chemotherapy drug), which are also highly purified chemicals taken from plants. If we wish to call huperzine A a natural treatment, we need to call these (and dozens of other standard drugs) natural as well.
What Is the Scientific Evidence for Huperzine A?
All clinical trials of huperzine to date were performed in China and reported in Chinese.
A double-blind, placebo-controlled study evaluated 103 people with Alzheimer's Disease who received either huperzine A or placebo twice daily for 8 weeks. 18 About 60% of the treated participants showed improvements in memory, thinking, and behavioral functions compared to 36% of the placebo-treated group, and the difference was significant. Benefits were also seen in an earlier double-blind trial using injected huperzine in 160 individuals with dementia or other memory disorders. 19
However, not all studies have been positive. Another double-blind trial of 60 individuals with Alzheimer's disease found no significant difference in symptoms between the treated and the placebo groups. 20 Such contradictory results are common when a treatment is only modestly effective, as may be the case here. In a 2008 detailed review of six randomized controlled trials, researchers concluded that, on balance, huperzine A appears to have some beneficial effects. However, the variable quality of these studies suggests that the evidence to date is not strong. 29
Huperzine is also promoted for improving memory in healthy individuals , but the supporting evidence for this claim appears to be limited to one small, poorly designed trial. 21
Huperzine A is a highly potent compound with a recommended dose of only 100 to 200 micrograms twice a day for age-related memory loss. We recommend using it only under a doctor's supervision.
Safety Issues
Perhaps because it works so specifically, huperzine A appears to have few side effects. However, children, pregnant or nursing women, or those with high blood pressure or severe liver or kidney disease should not take huperzine A except on a doctor's recommendation. We also do not know for sure whether huperzine A interacts adversely with any drugs; however, it seems likely that huperzine might interact with drugs that function in a similar fashion (such as standard drugs for Alzheimer's Disease).
Revision Information
- Reviewer: EBSCO CAM Review Board
- Review Date: 12/2015 -
- Update Date: 12/15/2015 -


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Folger Digital Texts use the text of Shakespeare's plays and poems from the Folger Shakespeare Library editions. The editions contain the work of Shakespeare on the right-hand pages, and notes, glosses, and illustrations on the left.
Folger Digital Texts use the same page numbers as the Folger editions. In the editions, the text of the play appears only on the right-hand, odd-numbered pages, so page numbers here are all odd numbers, too.
FTLN stands for Folger Through Line Number. To the right of the play, the lines are numbered in the usual way, starting over with each scene. To the left of the play are numbers that follow a simpler system: Folger Through Line Numbers.
With Folger Through Line Numbers, all of the lines in a play are numbered sequentially, from the first line of a play to the last. This makes it easier and more convenient to find any line.


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Ilana is a slide. Featuring a trio of elasticised and secured straps running up the vamp. The stretch of Ilana on the upper two straps will provide comfort and ease of wear while still being an on-trend design. Your perfect go-to slidse this season, Ilana by Naughty Monkey is versatile and will fit seamlessly into your casual wardrobe.
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Monday, February 15, 2010
Dating Suntory Old bottles
A 1950 Suntory Old
I have a feeling this post is going to disappoint some people. I get a lot of questions emailed to me and posted as comments here about the age and value of Suntory Old bottles. There are Japanese whiskies with older traditions, but I think the emphasis on age on this whisky's label raises hopes.
The first thing to clear up is that, although some bottles of Suntory Old have the date 1899 printed on them, none are that old. Suntory dates itself to 1899 but all bottles of Suntory Old date from 1950 onwards.
There are several generations of Old, reaching right up to the present day. Despite its name, it is not a particularly long matured whisky. It is a mid market blend (below Hibiki in Suntory's blended whisky pecking order but above Kakubin and the bargain basement Torys.) There are various ways to tell younger bottles from older version. Early bottles had the slogan: "A Blend of Ancient Whiskies". That was still on the bottle until at least 1868. Even after Kotobukiya changed its name to "Suntory" in 1963, the Suntory Old bottles appear to have continued to bear the "Kotobukiya" name. One way to tell really old Olds from 1960s versions is the addition of technical information at the far left bottom and far right bottom of the main label.
I am not sure when exactly things changed but, by 1994, " the label was different. The "Ancient Whiskies" were dropped in favour of "A Blend of the Choice Whiskies" and the main title on the whisky changed from "Suntory Whisky" to "Suntory Old Whisky". The line "Mild and Smooth" had also been added to the label by 1994 and the neck label had a completely different design. In 2006, there was another redesign, as you can see below:
The "Extra Special" bottle:
This bottle is owned by a reader of Nonjatta in Brazil and I must admit it has got me scratching my head. I have called it "Extra Special" because those words appear in the middle of the label and I have not seen them on other versions of Suntory Old. The owner says his family were given it by a Japanese diplomat in the 1980s. I have had questions from other readers about this particular bottling. Unfortunately, I have not been able to pin it down to a very precise time period.
I do know that a bottle similar to this was marketed abroad by Suntory and there does appear to have been a "Discover Suntory" campaign in the U.S. in the late 1960s that featured this brand. I say this because of this magazine advert:
It features our "Extra Special" bottle. This photo appears to be from the same campaign and its owner told me that his 1967 dating is based on a clear July 2, 1967 date on his slide mount (I have also dated the TWA campaign in the same picture to the same period). I think I can tentatively conclude from this that the "Extra Special" version of Suntory Old was sold abroad around 1967. It is almost definitely post 1963, because it is not described as being made by Kotobukiya, which was Suntory's company name before that date. The "Kotobukiya" name is echoed on the label, however: the kanji in the middle is "kotobuki", which has meanings associated with congratulations, happiness and long life (the same kanji is featured on a lot of neck labels for Suntory Old).
We have a fairly firm start date for this type of Suntory Old in the mid-1960s and some evidence from the marketing that it might have been exported in quite large amounts (perhaps even specifically made for foreign markets). What I don't know is when it stopped being distributed. The fact that the owner of this bottle thought it was given in the 1980s raises the possibility that it was produced over quite a long period.
There is one more detail that I should point out on this bottle which may or may not date it later than 1967. On the reverse of the bottle there is raised lettering on the bottle which says "A blend of the choice whiskies". If you look higher up in this post you will see that that phrase is featured on a mainstream bottle of Suntory Old in 1994 but not on its equivalent in 1968. I don't know when exactly Suntory started using that phrase, instead of referring to "ancient" whiskies as it had done earlier, but it may indicate that this is a later bottling. There may have been early "Extra special" bottling with the ancient description but I have never seen one. Another explanation might be that the change from "ancient" to "choice" may have been initiated on the "Extra Special" bottles and later carried over onto other versions. Here is the raised lettering:
Update 30.7.2010: My goodness, this post is getting really dorky but I just want to note that the strap line on these Suntory Old does appear to have varied considerably over the years. Another variation is below. It is another "Extra Special" Suntory Old but I think it would be a mistake to think that the "blend of rare selected malt whiskies" means this was a vatted malt. I think Old has always been a blend and that what that strapline means is that it is a "blend involving rare selected malt whiskies". Thanks to Tim from The Whisky Exchange for the photo, who said it came from a collection in Spain with a lot of bottles from the 60s and 70s.
Update 9.1.2010: Another reader has sent in some photos of an old bottle, which I am guessing comes from before or around the same time as the 1968 bottle at the top of this post. It carries the "Extra Special" mark and "kotobuki" characters. My current theory is that these marks were associated with bottles for export, and this one was exported into the U.S., as the photos below show. The use of "Kotobukiya Ltd." instead of "Suntory Whisky" might be taken to imply that this was exported prior to 1963, when the company changed its name. However, the photos at the top of this post show a bottle dated by Suntory as being distributed in 1968 also using the Kotobukiya name. My guess is that this is a bottle from the 60s or, possibly, earlier. As the reader who sent in these images points out, the back of the bottle is subtly different from the Suntory Old I posted about above: "On the back, where the bottle you posted has the company symbol, we have the same Japanese symbol as the front label."
38 comments:
- Unknown said...
This post is informative. But still it is not given here that
What is difference between various alcohol like: Single Malt, Single Grain, Blended Whiskey, whisky, vodka, gin, rum, cognac, brandy and cointreau..
I would like to share this link..hope u all like this:
- February 20, 2010 at 11:40 PM
Dear Amarjit
Thank you for the link. I do have to note, for the benefit of readers, that your definitions are not all correct (eg. you need to check again on single grain, check the spelling in the whisky/whiskey section, think again on all US whiskey being Bourbon, and be prepared for strong differences of opinion on your blended whisky characterisation) but anyway, that is just me being a alcohol nerd.
- February 21, 2010 at 2:08 PM
- Kris said...
I have a bottle of Old Suntory, extra special in it's original box (on front it says One U.S. Quart), unopened that was "Commemorating the Opening of New Tokyo International Airport". The label is very fancy with some gold on it. Do you know anything about this?
- June 1, 2010 at 9:07 AM
Kris, Your bottle probably dates from 1978 when New Tokyo International Airport, now known as Narita, opened. The 1 U.S. quart seems to suggest that, like I am guessing with the other "Extra Specials", this one was probably intended for an international audience. Perhaps it was sold in Duty Free at the opening of Narita.
- June 1, 2010 at 9:53 AM
- Skinny said...
I have a bottle of Old Suntory Extra Special 1US Quart 86 Proof. It belong to my father which he marked the date he bought it, 1977.
We have been keeping his collection since he passed 9 years ago. I am not a drinker therefore I am doing research to estimate its value today and put it on Ebay. Any indication on its value is greatly appreciated.
Thanks, Alfred
- November 13, 2010 at 2:49 PM
Dear Alfred
It sounds an interesting bottle. Unfortunately, I do not know what the going rate for these bottles is.
- November 13, 2010 at 5:13 PM
I have an unopened bottle of Suntory Royal 60 Rare Old Whisky Special Reserve.
I'm guessing it is approximately 30 or more years old but can't remember when it was presented to me.
Is it worth anything?
- November 16, 2010 at 4:51 AM
To be honest, Dick, I have no idea. If it was 30 years old and you could prove it, then it would be worth something, but I have no idea how much.
- November 16, 2010 at 9:44 AM
I also have a 1 qt bottle of "Extra Special" Old Suntory. I received it as a gift in the mid-1970s. My bottle has a different label with special graphics. It commemorates the opening of the New Toyko International Airport.
Let me know if you want me to send photos.
- January 10, 2011 at 9:06 AM
Very interested in pictures
- January 10, 2011 at 12:57 PM
Here are the photos of my commemorative 1qt bottle of mid-1970's Suntory for the opening of the New Toyko International Airport.
Let me know if anyone is interested in owning this rare bottle.
- January 11, 2011 at 9:26 PM
- Renna Fox said...
Hello Nonjatta,
I was reading your post of Dating Suntory Bottles and I felt the need to comment on them. a year or so back, my aunt was helping out remodeling a mansion in San Francisco and there was a bottle of liquors and spirits. I was allowed to take what I wanted home and i took the whole box XD. Anyways. In the box was an Old Suntory Whisky Extra Special. I was curious about it today do to drinking of this day. I was wondering how do you tell when they are good enough to drink and when their not? most haven't been opened like the Suntory. Some of the others are Creme de Coca?, creme de menthe, Faretti Biscotti liqueur, creme de chassis, Peachtree schnapps and blackberry brandy etc. Could you give me an idea? I'd also like to send a photo of the bottle, since its the one with rare selected whiskies.
With thanks,
- January 1, 2012 at 8:44 AM
- SUKI MIXSON said...
How about the label "very rare old Suntory Whiskey" My mother in law was Japanese.
- May 28, 2012 at 6:20 AM
- hAMBERger said...
Did you find out any good info on the suntory royal 60 please email me at email@example.com thx
- July 5, 2012 at 11:01 AM
I have an unopened bottle in it's original box of "Very Rare Old Suntory Whisky" which commemorates the 1972 XI Olympic Winter Games in Sapporo. Has a luggage tag included! Anyway, any idea whether it's of value or even drinkable?
- July 29, 2012 at 2:57 PM
Probably very drinkable. My general impression is it is unlikely to be very valuable
- August 3, 2012 at 4:43 PM
Thanks for the feedback...I'll post our impressions after we crack it...
- August 4, 2012 at 5:55 AM
Would be very interested in your impressions. By the way, on the valuation front, I definitely have no experience doing that, so please don't take my word for it. It is just that there are so many bottles around that my gut reaction is that it is not going to attract a large valuation.
- August 4, 2012 at 10:26 AM
- Unknown said...
We found a Suntory Whiskey bottle on the Oregon Beach a few years back. No label but the words "Suntory Whisky" raised on a brown bottle....I recently started researching to figure out how old it is. The cap on it is plastic.......my guess is that means it may not be that old- it looks cool though:) Any help would be appreciated
- August 6, 2012 at 1:26 AM
As I say in the article, all Suntory Old bottles date from the 1950s at the very earliest, and the vast majority will be much much younger. They still sell the brand. However, I find the fun of these bottles is not so much the age but the question of how they got where they were found
- August 19, 2012 at 4:36 PM
I have an unopened bottle of Very Rare Old Suntory Whisky,760ML,43%,circa 1963 distilled at Yamazaki.Osaka, Japan in excellant condition and wish to know its value.4215
- February 17, 2013 at 2:44 AM
Regarding my entry of Feb 16,2013,2;44, I am reachable at email@example.com
- February 17, 2013 at 3:10 AM
- Unknown said...
Hi folks,
I'm wondering if anyone can help me. I have a Suntory Kiezo Saji Signature bottle labeled AGE UNKNOWN. It came in a wooden box and was given to my father, Robert H. Jones a Canadian outdoor writer), by Kiezo Saji in the early 80's when my father was featured in several Suntory ads.The bottle is empty, (dad liked his Scotch). I'm curious to find any information on it and also to see if it has any value. I don't see any way to upload photos to the blog, but I can e-mail them to anybody that is interested.
My address is firstname.lastname@example.com.
Thank you for your time,
Bob Jones
- July 10, 2013 at 1:11 PM
Great history. I have 2 bottles, unopened, in boxes of Old Suntory that I found in my father's garage. He was in contact daily with JAL pilots and we vacationed in Japan in 1963/64. I don't know exactly when he either purchased or received this bottle. I will take pictures. The front says Extra Special, above that it says The Final Choice of Mature Taste, it is 4/5 Quart 86 proof, Distillery at Yamazaki,near Kyoto Japan. Any info on the value or lack thereof would be appreciated or a link to where I could find out.
Thanks for your help
Elly Troutman
- September 11, 2013 at 4:51 AM
- winston Creel said...
I have a bottle of Suntory Whisky that looks just like the early 60's bottle but mine doesns't say old just A blend of rare ,Selected whiskeys the back says imported by los Angeles california 90017 usa
there is a US revenue distilled spirits label closed over the cap.
Any Idea of the age or history behind it?
- November 14, 2013 at 11:22 AM
I recently got a bottle of Suntory Whisky on a small island in micronesia (only 4 people live there) and one says a blend of the choice whiskies which i suppose is rather new.. The other two that i have dont have a slogan on it at all and it has a totally different design on it. Just looking to see how old it could be. Thanks
- November 15, 2013 at 2:28 PM
- vikramsamal said...
I have two bottles of Suntory whiskey where the label says Extra Special Old Suntory Japanese whiskey.Distilled and Bottled by Suntory Ltd. Could you please share more information on the same.
- July 5, 2014 at 1:21 AM
- kinji yamamoto said...
I have a friend that wants to sell to me an Suntory Whisky, in the label says: "Very Rare Old Suntory Whisky" in an gold label.
It is bottle for: "Commemorating the openning of New Tokyo International airport", my question, do you know how much is this bottle? (closed and full of whisky).
Kinji Yamamoto
- August 20, 2014 at 1:36 AM
- William Harris said...
I really love Suntory!!
- September 27, 2014 at 2:47 AM
Hello. I have a Suntory bottle written: Suntory Limited Torys Extra Blended Whisky, but i don't find neither a photo of it or any information. Can anyone tell me something about this bottle?
- February 9, 2015 at 10:19 AM
I recently had an unopened bottle of Suntory Old Whisky stolen from my home. It was at least 30 years old, given to me by a friend who traveled. Does anyone have an idea of its worth? Thanks.
- February 28, 2015 at 11:43 PM
- Kirsten said...
Just cracked a bottle that I inherited from my father. It's been in the basement on a shelf in its original box since who knows when... he traveled a lot on business when I was a kid. Same bottle as the one first posted. Guessing it's from the early 70's. Very tasty!! Super smooth.
- September 19, 2015 at 8:46 AM
- Unknown said...
I recently came across a Rare Old Suntory Whisky bottle that was dug up in Silver Bow, Montana in 1966. I've looked all over the web and can't find any bottles like it. I'm not concerned with value, but I am VERY curious as to its possible age and history.
It is a rather petite, clear, square sided, bottle that is 3" wide by 1 3/16" thick by 5 1/4 tall. Etched into the glass on one side, arched across the top, is "Rare Old Suntory". It is smooth and blank under. I assume a paper label may have been there.
On the other side, etched in the glass, is "Rare Old" on top, the Suntory crest in the middle, "Suntory Whisky" below the crest, and in small print etching below that "Vatted over 10 years"
The crest is very detailed and says "Suntory Premier of Japan Whisky" in the ribbon at the bottom of the design
Any input you may have would be greatly appreciated. I would attach pictures, but am not quite sure how to do so.
Thank you for you time,
- November 12, 2015 at 7:26 AM
- Unknown said...
Derek Y. Horizumi My father was Japanese American businessman, he conducted business with Japaneses companies: DJK & JAL. DJK sold Deicing equipment to the airports in 1977-1978, he brought home from Japan, a bottle of Suntory Old Extra Special, but it had a Shogun Warrior shoulders and top with G&G written on it.
- November 20, 2015 at 8:02 PM
- Unknown said...
what year is this?
- February 19, 2016 at 1:39 PM
- Unknown said...
Can you tell me anything about the bottle with the raised geisha on the front. Thanks Eileen
- August 5, 2016 at 1:00 AM
- Sifting through the past. said...
I have this bottle that went into a suitcase in the attic in 1983. (Exact year) I have only just opened the case for the 1st time to deal with it all. Slightly different bottle to those you pictured. If you want a pic let me know can't work out how to post one here.
- December 15, 2016 at 10:16 AM
- Unknown said...
I have a bottle of Rare Old Suntory WHiskey It is at least 45 years old and unopened. Back says it was blended by Sinjiro Toril and matured in wood Also says distilled by Kotobukiya Limited. It is a clear rectangular bottle. Label say it was vatted at the Yamazaki Cellar I can't find any posted pictures of a similar bottle. How can I find out more about it and if it of value?
- July 30, 2017 at 1:22 AM


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Cystic fibrosis (CF) is an inherited disease. It causes a defect in certain cells of the lung and digestive systems. The defect makes the cells produce a thick, sticky mucus. This mucus can cause:
- Blockages in the lungs and airways
- Problems digesting and absorbing nutrients
CF is a serious life-long condition, but the severity of the illness can vary greatly. The average life expectancy for someone with CF is about 35 years. Although, some with mild forms of CF can live to age 60 or beyond.
CF is a genetic disorder. A child with CF inherits defective genes from each parent. Parents who have the gene, but do not have CF, are called carriers.
Risk Factors
Factors that increase your chance of CF include:
- Parents who are known carriers of the CF gene
- Siblings with CF
- Parents with CF—more often the mother since men with CF may be sterile
The abnormally thick mucus of CF blocks certain organs. This causes many of the symptoms of CF.
Symptoms in infants may include:
- Difficulty passing the first stool
- Salty sweat
- Intestinal obstruction, sometimes requiring surgery
Mucus that causes blockages in the lungs may lead to:
- Coughing and wheezing
- Shortness of breath
- Difficulty with exercise
- Abnormally shaped clubbed finger tips
- Malformed chest
Mucus can also block the pancreas. This can block enzymes used to help you digest food. This can lead to:
- Bulky, bad-smelling, floating stools, due to poor digestion of fats
- Diarrhea
- Trouble gaining weight
- Poor growth
- Failure to thrive
- Malnutrition
- Dehydration
Other symptoms may include:
- Jaundice or other symptoms of liver disease
- Chronic nasal congestion from chronic sinus infections
- Rectal prolapse
- Nasal polyps
- Excessive thirst or urination that may indicate diabetes mellitus type 2
- Stomach pain or swelling from intestinal blockage
- Prevention of sperm production in males
- Mildly decreased fertility in females
Overall, girls are affected more severely than boys.
You will be asked about your symptoms and medical history. A physical exam will be done. CF is suspected in a child with classic symptoms, especially if a sibling has CF.
CF is often diagnosed by symptoms, family history of CF, or a positive screening test in newborns. The diagnosis may be confirmed with genetic testing. Other lab tests that may be used to confirm CF include:
- Sweat chloride testing
- Transepithelial nasal potential difference measurement
Your lungs may be tested. This may be done to look for symptoms or to determine treatment. Tests may include:
- Chest and/or sinus x-rays
- Lung function tests
- Sputum cultures
Tests may also be needed to check the pancreas. These tests may be done to assess symptoms or determine treatment.
There is no cure for CF. Treatment is aimed at:
- Improving the amount of nutrition your body receives
- Preventing and treating lung and sinus infections
- Keeping the airways and lungs as clear as possible
Treatment for CF includes:
Nutritional Support
Better nutrition will help improve overall health. It will also improve growth and development in children. Children who have returned to normal weight within 2 years of the diagnosis have fewer coughing episodes and better lung function. Some nutritional steps that may help include:
- A high-calorie diet planned by a registered dietitian
- Nutritional supplements, including fat-soluble vitamins
- Pancreatic enzyme tablets with meals to improve digestion and absorption of nutrients
- Drinking lots of fluids and salt replacement, especially in hot weather or during illnesses
Managing Lung Infections
Thick mucus in the airways increases the risk of respiratory infections. The infection can also be more severe because of the mucus. Treatment of a current infection often requires antibiotics. Prevention of new infections may be done with:
- Vaccination
- Antibiotics (usually inhaled)
Lung and Airway Support
Medications help keep the airways clear. Most will be delivered through an inhaler or nebulizer. Medications may include:
- Bronchodilators—to relax muscles and open the airway
- Mucolytic agents—to reduce mucus and help it move out of the lung
- Steroid inhalers—to decrease swelling and irritation (only when necessary)
Other steps that may help clear mucus from the lungs include:
- Hypertonic saline is a special type of salt water. A nebulizer machine creates a mist of this saline, which is inhaled. The mist may help thin out the mucus in the lungs.
- Chest percussion is rhythmic clapping over the chest. They may help clear mucus from airways. It is most helpful if done at least twice per day.
Oxygen therapy may be required as the disease progresses. Ventilation may also be needed. Talk to your doctor about whether these are options for you.
Other Treatment
Surgery may be required to treat blockages in the intestine. Lung and liver transplants may also be considered.
Support is important for those with CF and their families. Ask you doctor about local support groups or counseling options.
If you have the defective genes, there is no way to prevent CF.
Adults can be tested to see if they carry the genes before having children. Prenatal testing can determine if a baby will have CF.
Revision Information
- Reviewer: EBSCO Medical Review Board David A. Ostrovsky, MD
- Review Date: 03/2018 -
- Update Date: 02/12/2016 -


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Get your business plan done today!
Avoid the dreaded 'Blank Page Syndrome' and do the smart thing by starting your plan with one that's almost complete. The Russian Restaurant business plan is a 17 page business plan written for an actual Australian Russian Restaurant business applying for bank finance.
We have sensitised the plan and made it more generic to make it suit a wider range of businesses. All that is left to do is to follow what we have written and customise the content to reflect your business.
Why waste time trying to write a business plan from scratch, time is money!


text:
Start chatting to our centre now by clicking the button above
Our team at Williams BMW is committed to providing outstanding service to our customers.Make An Appointment
The all-new BMW 3 Series Saloon is the ultimate sports sedan: equipped with efficient engines, the latest driver assistance systems and innovative connectivity technologies - the perfect car for your business. Find out more.
A sense of dynamism and motion are reflected in the sweeping new lines of the sleek yet sporty silhouette. Iconic curves have been accentuated and a lower, more refined stance revealed.
Lighter and lower, we've finely tuned every element of the new BMW 3 Series to create a drive that's as smooth as it is engaging. The near-perfect 50:50 weight distribution improves balance, resulting in superior responsiveness and handling.
Inside the driver-oriented interior, a host of next generation Driver Assistance Systems come to life at the driver's command. Voice and gesture-controlled displays respond to their needs, big or small.
If you run a fleet of more than 50 cars we can provide a personalised quote on the right cars for your fleet. With a dedicated team on hand to help you make the best choices, understanding your fleet options has never been easier.
Company car tax laws and regulations can be confusing. To help you make the best decision for your fleet and ensure you understand the tax implications of running a company car, our company car tax guide provides a break down all of the key information and changes.
The headline offers below are a small selection of models available. For additional offers click belowAdditional Offers
No offers found with your current search criteria.


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BOSTON — Chelsea Gray couldn't suppress her happiness after picking up her 10th assist of the game. And she couldn't hide it afterward when she talked about matching Dawn Staley's conference record with a second career triple-double.
"I'm not surprised," Duke coach Joanne McCallie said after Gray scored had 18 points with 11 rebounds and 10 assists to lead No. 3 Duke to a 90-53 victory over Boston College on Sunday. "She'll be getting a lot more of those, I'm sure."
Gray had nine points, eight rebounds and seven assists in the first half, when Duke scored 12 of the first 14 points and made it 32-5 just 11� minutes into the game. She was stuck on nine assists until McCallie told her to "make a nice pass" in the final minutes -- and she did, hitting Richa Jackson for an open jumper with 56 seconds left.
That tied her with Staley, who led Virginia to three Final Fours and a NCAA title game and also won three Olympic gold medals, as the only players in Atlantic Coast Conference history with more than one triple-double.
"It feels good. It's exciting to hear that," Gray said. "When it went in, I went back and tried to hide a little smile."
Tricia Liston had 17 points, scoring 12 during a 20-0 run that put the game away, and Jackson scored 16 for the Blue Devils (13-0, 3-0 ACC), who remain the only unbeaten team in Division I. Top-ranked Connecticut lost to No. 5 Notre Dame on Saturday; No. 2 Baylor entered Sunday's game against Oklahoma State with an 11-1 record.
Kristen Doherty scored 17 points and added six rebounds for BC (6-7, 0-2). The Eagles lost their third consecutive game, including a 76-70 loss to then-No. 23 Florida State -- the only other ranked team they have faced this season.
This one wasn't that close.
Duke made its first six 3-point attempts and tied a school record by making 79.3 percent of its shots in the first half to open a 55-20 lead. BC scored the first eight points of the second half, but never got within two dozen points.
"We didn't back down. We went right at them, and suddenly Duke realized, `Hey, we've got a basketball game on our hands,"' BC coach Erik Johnson said. "Unfortunately, Duke's so good, and played so well in that first half that the game wasn't really in question by the time we got it rolling."
Trailing by 35 at the half, Doherty hit a 3-pointer to open the second and Nicole Boudreau drove to the basket for a layup, prompting McCallie to call a timeout. Boudreau made a free throw, then Tessah Holt made a pair as the Eagles continued to force turnovers.
"I was just very mad," said McCallie, former head coach at the University of Maine. "I don't think it put a scare, two turnovers in a row is just very silly."
BC had several more chances to cut the deficit further but couldn't make its shots. Gray scored on a foul line jumper with 16:25 left to play to end the Blue Devils' scoring drought.


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13″ x 10″ x 15″ x 10″ – Our Medium Duty 80 GSM Non-Woven Market Tote is made with durable, reusable non-woven polypropylene. Features 22 inch dual reinforced handles that extend from the top to the bottom of the bag for extra strength. Includes polyboard bottom inserts. Available in 9 popular colors. Our EnduraChrome full color digital process allows full photographic reproduction of your logo. Side gusset printing available.
EnduraChrome™ Non Woven Market Tote – Medium Duty
Item #: NWT1315LEC
Valid through 12/31/2020
|Price (4R)
- Size: 13" width x 10" side gusset x 15" height x 10" bottom gusset
- Material: 80 GSM Non-Woven Polypropylene
- Printing: Price includes full color digital reproduction in one location
- Maximum Imprint Area: 5 x 10
- Additional Color Charge: $1.40 (V) For 2nd side digital print
- Set-up Charge: No set up charge For a full color digital reproduction in one location
- Production Time: 10-15 working days
Additional Information
|Printing Method
|EnduraChrome™ Digital Process
|Side Gusset Printing
|$.40 (V) For Each Color or Location
|Color Matching
|Not Applicable
|Standard Quantity per Case
|Weight per Case
|26 lbs
Artwork Guidelines
Preparing Artwork
Following are standard artwork guidelines. For your specific project, we are always available to offer assistance in art preparation and submission. Please contact us with your project details and we will be happy to assist you.
EnduraPack accepts artwork in any format. Vector art is preferred, to ensure accurate reproduction. All artwork should include the format used, distributor name, PO number and complete contact information.
Sending Your Artwork
Files under 5MB can be emailed to email@example.com. For files over 5MB, please upload them directly to us athttps://www.hightail.com/u/EnduraPack. Please include a PDF version of your art for reference purposes. Multiple files and large files should be compressed or stuffed. Complete contact information must be included in your email.
What Type of Artwork We Prefer
We have the most recent software versions of Adobe Illustrator, Adobe Photoshop, Adobe Acrobat Professional and Quark Express. Additionally, please follow these guidelines when submitting electronic art:
- Send vector art whenever possible
- Convert fonts to outlines
- Art should be 300dpi at actual print size
- Indicate / send artwork to size.
We use the Pantone® System for printing spot colors. Pantone® Colors should be indicated directly on your file and order.
All artwork will be sized according to your instructions. If there are no instructions, we will size and position the art to the product using our own judgment. Rest assured, we want it to look as good as you. See maximum print areas for the specific product you are decorating. PDF Layout proofs are provided on all new artwork orders unless otherwise agreed.
What Type of Artwork We Will Revise for You
The following "artwork" will need to be recreated by us. It might take a bit longer, but don't worry. We'll work with what you have.
- Low Resolution JPG/JPEG
- Bitmapped Art (BMP)
- Microsoft Office Programs (i.e., Word or Powerpoint)
- Email Content
- Scans of Art
Templates are available for our most popular products. See the individual product pages to download templates. In Adobe PDF format, they can help you in placing art, and preparing presentations.
Don't hesitate to contact us. We'll get back to you and answer your questions. Quickly.
Terms & Conditions
For a complete reproduction of our Terms, you may download this information to a PDF Document
Due to the volatility in the cost of raw materials, the prices at endurapack.com are subject to change at any time and without notice. Contact EnduraPack for most up to date information.
Production Time
Typical production time is 10 working days on repeat orders and 15 working days on new orders. However, these times may vary due to the volume of business we are working on. Rest assured, we want your business; so if you have a sure-dated event order, or even one which needs to ship before the above production time, contact us. Air shipments may be required in order to meet sure-dated orders, but we'll discuss this together. Non sure-dated orders are approximate and all efforts will be made to maintain these dates. Sometimes things just happen in the manufacturing process and delays sometimes occur. Our work is customized for you and only for you. So merchandise manufactured must be accepted whether or not these dates are maintained.
Rush orders
Some items in this catalog are available in 3-5 day production. A rush charge of $125.00 will apply once order and schedule are accepted.
On new orders, PDF color layout proofs are submitted via e-mail. No charge. We'll need your approval before we can begin production. Digital color-key proofs, if required, are available at an additional charge of $150.00 net. For certain items, pre- production sample proofs are available at an additional cost. Contact EnduraPack for details. Questions on plate charges must be settled before proof is approved. EnduraPack's liability for accuracy of printed material ends with the customer's approval of the proof..
EnduraPack operates manufacturing facilities in New York, Michigan, California, and various locations in China. For approximate freight quotations, please contact EnduraPack. Unless otherwise notified, we will select the most appropriate shipping method for your order, including common carrier, UPS or other methods. If you have a specific carrier or request for third party shipments, just let us know and we will accommodate you. Please note that freight quotes are only estimates and are subject to change without notice.
Drop Shipments
Shipments to multiple destinations will be charged as follows: If a shipping manifest is supplied, listing each destination with the number of cartons going to each destination, along with shipping labels for each carton required, the charge is $10(V) per destination. If labels and manifests are not supplied, the charge is $20(V) per destination. On drop ship locations requiring 25M or more bags per destination, there will be no drop ship charge. Partial cartons require special packing and may be available at an additional charge.
Cancellations of orders
There will be a $75 charge for any order cancelled. This will be in addition to any artwork, plate or other material and/or labor costs incurred at time of cancellation.
No item may be returned without an approved return authorization form and authorization number. All shipments will be inspected upon receipt. Returns are subject to a 15% restocking fee.
Due to the nature of manufacturing, all orders are subject to +/-10% overrun or underrun. All invoices will be rendered for actual (total) quantity shipped. Any special arrangements must be discussed with us before order is accepted (absolute minimum requirements or client budgetary restrictions, etc.).
Bag colors
Stock bag colors shown in this catalog are illustrative only. Actual bag colors will vary.
Process Printing
4-color process printing requires prior approval of artwork and special quotation. Contact us for more information.
A small, solid, rectangular box may print at the bottom corner on one side of each printed bag. This box, known as an eyespot, is necessary for bag-making operations. For more information, contact us.
Final Notes
No estimation given by EnduraPack personnel will be considered official until we are in possession of the actual art submitted and until firm art and plate charges are given with the pre-production proof. No plate charges are considered official until the customer approves the pre-production proof in writing.


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Mo. Lawmakers Want to Nullify Federal Gun Limits
JEFFERSON CITY (AP) - President Barack Obama's call for greater gun restrictions is being met with opposition in the Missouri Legislature.
Obama called upon Congress on Wednesday to ban assault weapons and high-capacity ammunition magazines as part of a sweeping package aimed at reducing gun violence.
But at the Missouri Capitol, Republican state Sen. Brian Munzlinger filed legislation Wednesday that attempts to nullify any federal law restricting semiautomatic guns and accessories. Munzlinger's bill would make it a felony for federal agents to try to enforce a ban on guns that are made and remain in Missouri.
A similar bill was filled Tuesday by Republican Missouri House member Casey Guernsey. It's co-sponsored by more than 60 representatives.
Some Democratic lawmakers say the bills are a waste of time, because federal laws supersede conflicting state laws.


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Symptoms of hypothyroidism begin slowly over weeks or months. You may have hypothyroidism for a long time before you realize you are ill. Symptoms change with the degree of hypothyroidism and how long your body has not had the proper amount of thyroid hormone.
You may have only one of these symptoms, but most people have a combination. Some with hypothyroidism do not have symptoms or have mild symptoms that go unnoticed for a long period of time.
Symptoms include:
- Enlarged thyroid gland, called goiter (not always present)
- Fullness in the neck
- Difficulty swallowing or trouble breathing (can happen if the goiter is very large)
Other symptoms or signs include:
- Fatigue
- Weakness
- Coarse, brittle hair and hair loss
- Dry, scaly skin
- Unable to tolerate cold temperatures
- Weight gain (may happen despite having a poor appetite)
- Constipation
- Achy feeling all over
- Depression and irritability
- Memory loss and personality changes
- Irregular or heavy menstrual periods
- Facial puffiness
- Swollen feet or hands
- Infertility
- Reduced sweating
Symptoms of severe or extended cases include:
- Swelling of the skin and tissue around the eyes
- Bradycardia—slow heart rate
- Hypothermia—low body temperature
- Shortness of breath during activity or when lying flat
- Drowsiness and lower mental alertness
Revision Information
- Reviewer: James P. Cornell, MD
- Review Date: 02/2017 -
- Update Date: 03/15/2015 -


text:
President Barack Obama's Attorney General sent a crisp missive to Rand Paul Thursday, responding to the Kentucky Republican's filibuster to block John Brennan's nomination for CIA director, over the Obama administration's drone policy.
The letter, posted in full below, reads simply:
"It has come to my attention that you now have asked an additional question: 'Does the President have the authority to use a weaponized drone to kill an American not engaged in combat on American soil?' The answer to that question is no."
Hearing the letter for the first time on Fox News Thursday, Paul said that the answer satisfies his question.
"HOO-ray!" Paul said, adding that Holder capitulated "under duress."
During his 13-hour filibuster Wednesday, Paul claimed he would block Brennan's nomination until the White House answered his question about whether the U.S. could authorize a military strike against U.S. targets.
Paul's complaint centered around a March 4 letter from Holder, which vaguely stated that the Obama administration could, "hypothetically," carry out drone strikes against Americans on U.S. soil, but "has no intention of doing so."
"It is possible, I suppose, to imagine an extraordinary circumstance in which it would be necessary and appropriate under the Constitution and applicable laws of the United States for the President to authorize the military to use lethal force within the territory of the United States," Holder wrote in that letter.
Asked by Senate Republicans Wednesday whether that meant the U.S. could kill any suspected terrorist who was not posing an imminent threat, Holder said the question was not "appropriate."
Here's the full text of today's letter:
And here's the first letter:


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Maximise personal experiences. And ad revenue.
Get to know old customers. And find new ones.
Adobe can help. Adobe Audience Manager lets you target the same customers across every channel by bringing all your data into a single profile. This allows you to find new customers using attributes from your most valued segments. With Audience Marketplace, you can scale your high-value audience segments to deliver targeted content on every channel. And Audience Marketplace lets you quickly buy and sell second- and third-party data — without setting up individual partnership agreements.
Get a detailed view of every customer.
Personal ads with your video experiences. No complex coding.
Adobe can help. Adobe Primetime lets you build and deliver high-quality video content that can be watched any time and on any device — creating more value for your pay-TV service and strengthening brand affinity for content owners. And you can develop video experiences with software development tools that let you quickly deliver to mobile and OTT devices. Which means you can dynamically insert ads into your video content across every screen.


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The sassafras tree, a native of North America, has a long history of use both as flavoring and medicine. The oil extracted from its root was one of the original constituents of herbal root beer. As medicine, it was used to treat influenza and other fever-producing infections, as well as arthritis, urinary tract infections, and digestive disorders. It was also commonly used as a "spring tonic" or "blood purifier."
However, in the 1960s, it was discovered that sassafras oil contains high levels of a liver toxin named safrole. 1-5 When given to animals, safrole causes liver cancer, and even a single cup of sassafras tea contains dangerous levels of the substance.
Because of this, sassafras has been banned for human consumption. Only safrole-free products can be sold; however, there may be other carcinogens in sassafras besides safrole. 6
Sassafras oil is also immediately toxic; a few drops can kill an infant, and a teaspoon can cause death in an adult. 7
For all these reasons, we strongly recommend against the use of sassafras for any purpose.
Revision Information
- Reviewer: EBSCO CAM Review Board
- Review Date: 12/2015 -
- Update Date: 12/15/2015 -


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A lack of appropriate management skills have been cited as the key cause of that failure. One way to offset a lack of management skills is to outsource them to experts. For most small businesses this is beyond the reach of their limited budgets. A more viable option is to develop the skills you need to manage your business operation. Let's examine the key competencies you will need.
Strong sales and marketing skills are vital in the promotion of your small business and its products and services.
As the business owner you must take responsibility for the management of your finances.
It is essential that you develop an awareness of your legal rights and obligations.
You need to build operational management skills in order to develop the systems and processes.
It is important to remember that each of the required skills are not discrete skill sets. To be truly effective as a small business manager, you need be able to integrate each of the core management skills.


text:
Separate names with a comma.
Discussion in 'International iPad Users' started by saber.zainal, Jun 8, 2011.
Thanks Apple team for amazing features
Good to hear from you. You'll find a whole bunch of iPad enthusiasts in this Forum who are only too willing to help other iPad owners and to hear of their experiences. Don't be afraid to post any questions you may have or use the 'Search' button near the top of the Forum web page. I usually find I discover one new interesting and useful piece of information about my iPad every day - and often not even what I was looking for!!
Hope to hear from you soon with your thoughts about the iPad.
Have fun and enjoy your iPad
If you don't already have it you can download a copy of the iPad manual for free.
Apple - Support - Manuals
Please read the rules too!!


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Fluorosilicic Acid Market Size By Grades (40%, 35%, 25%), By Application (Water Fluoridation, Textile Processing, Metal Surface Treatment, Hydrogen Fluoride, Aluminum Fluoride, Silicofluorides Electroplating, Hide Processing, Oil Well Acidizing), Industry Analysis Report, Regional Outlook, Application Potential, Price Trend, Competitive Market Share & Forecast, 2019 – 2025
Published Date: Apr 2019 | Report ID: GMI3248 | Authors: Kunal Ahuja, Kritika Mamtani
At Global Market Insights, our researchers and domain experts use a unique blend of primary and secondary research, with validation and iterations at every stage, in order to minimize deviation and present the most accurate analysis of the industry. The research process begins with extensive data mining, using authentic sources such as trade magazines, technical publications, independent studies along with paid avenues such as ICIS, Hoovers, etc. Primary objectives of data mining include:
- Definition and scope of research
- Market dynamics, growth drivers and industry pitfalls
- Regulatory and political guidelines for the industry
- Demographics and statistical data
All the above factors are identified and analyzed in detail, with their present and expected market impact, which is quantified and used to derive market growth expectation. Market forecast is built using statistical analysis with models built around time-variance, regression and correlation analytics.
Significant emphasis is put on primary research, which serves the dual role or not only validating our findings but also obtaining penetrating market insights, which help us gain more clarity regarding business environment and competitive leverage. Notable participants in our primary research process include:
- Leadership figures such as CEOs, CSOs, VPs etc. in key companies
- Supply-chain participants, distributors and domain experts
- Key customers and B2B clients
Market research reports: Key analytical components
Market Insight Coverage|
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Reliability & accuracy
- GMI is unparalleled when to comes to the quality of research and information provided to clients. Our unique methodology is designed to ensure a minimum of 90% accuracy to give our clients excellent value on their investment.
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Biography | Video | News
Coming Soon ...Read More
The song Izere By Idk Too Faster Ft Lolilo was chosen to be promoted by indundi media because we believe the message in the song can influence positivity in our society. We will continue to promote this artist as we believe that he is making impact in our community.
Coming Soon ...Read More
Downloads(936) | Played(2172) | Download
Indundi.com is a multi-media content service provider and the largest electronic source of information on the Burundian music scene. Established in 2006, our website serves as an international musical archive to Burundi, Africa and the world as a whole.


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Best 5-Year TFSA GIC RatesRates updated:
We compare what all the banks and lenders offer, to bring you the best TFSA GIC rates in Canada. Once you've found the rate you want, we'll help walk you through the process of making your initial investment. Keep reading to find out what the benefits of holding GICs in your TFSA are.
Did you know that rates differ significantly between financial institutions, and within the various channels / methods where you purchase? Browse our Education Centre to learn about the GICs that best suit your saving needs.


text:
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Get the best deal for way less here than you will with other ISPs. Check out our cheap prices before you sign any contracts.
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Stay protected with a security system from Safe Choice Security and BroadbandBLUE. Prices starting as low as $8 a week!
Choose Broandband Blue internet service in Belfield, ND and experience the difference true speed makes when it comes to your Internet connection. Broadband Blue is the preferred broadband Internet service provider in the area because it brings you options. Satellite Internet and wireless 3G/4G Internet are both available so you get exactly the reliability, speed and freedom you are looking for in a high speed broadband Internet connection.
Broadband Blue Adapts To Your Needs! Broadband Internet service provider Broadband Blue brings you HughesNet Gen 4 in Belfield, North Dakota. This service is both the fastest option available in Belfield and it is also the least expensive. With a solid history of connecting America to telecommunications, nobody is better than HughesNet for Internet connectivity. With it you can browse the web at your speed, use Skype, social media, apps, download big files and more. For Internet to take on the go, no data caps or fast-twitch gaming options, the other Broadband Blue option – wireless Internet in Belfield, North Dakota is the perfect solution. Look to broadband Internet Service Provider Broadband Blue to connect you the way you want and need to be connected. If you need internet, we have you covered!
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Artist/maker unknown, American, Pennsylvania German
Made in Montgomery County, Pennsylvania, United States, North and Central America
Redware, lead glaze, white slip (for sgraffito decoration), copper oxideDimensions:
3 5/8 x 3 3/8 inches (9.2 x 8.6 cm)Curatorial Department:
American Art
* Gallery 215, American Art, second floor (Johnson Gallery)Accession Number:
1913-471Credit Line:
Purchased with the Baugh-Barber Fund, 1913
Social Tagsnhd 1783 to 1815 ceramics [x]
[Add Your Own Tags]
This beaker was made from high-quality clay found under the wet topsoil of Pennsylvania's low-lying plains. Southeastern Pennsylvania's terrain could support farms on the topsoil and potteries on the subsoil, so by 1810 potteries could be found in almost every township in Buck's County.
The work of the potter fit into the agricultural calendar. The clay was dug in the fall: topsoil was cleared and a foot-deep layer of clay was sliced and shoveled into a wagon, hauled to the pottery, and stacked. Before freezing weather, the clay was carried in baskets and dumped into a mill - a round tub with a revolving post set with blades. A horse harnessed to a sweep walked slowly around the tub, turning the blades. Water was flushed through to clean the clay and the resulting mass of plastic earth turned gray to yellow. The clay was then shaped into one hundred pound blocks and stored in a cellar where it was kept moist but would not freeze.
This beaker started out as a flattened ball of clay. The cone-shape with rounded edges was formed by the potter on his wheel, which was rotated at variable speeds by the potter pushing a foot wheel, which in turn was connected to a balance wheel, allowing for smooth and continuous rotation.
Colorful slip (an opaque glaze) and sgraffito (incised) ornamented the ceramic wares, such as this one, and were the presentation pieces of the rural potter. Thin white slip was applied to the surface when the ware was damp, and the decorations are sgraffito, which is a technique highly developed by Pennsylvania potters. Outlines and solid areas were scratched through a coating of slip to reveal the red underbody, which then shone red through the glaze. Copper oxide daubed on before glazing created the vibrant green accents. Everything except the bottom is covered with a clear brownish lead glaze.
Explore the Collections
* Works in the collection are moved off view for many different reasons. Although gallery locations on the website are updated regularly, there is no guarantee that this object will be on display on the day of your visit.


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In the latest issue:
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If you subscribed via the website, you can enter the order number from your subscription confirmation email in place of your customer number.
These terms and conditions of use refer to the London Review of Books and the London Review Bookshop website (www.lrb.co.uk — hereafter 'LRB Website'). These terms and conditions apply to all users of the LRB Website ("you"), including individual subscribers to the print edition of the LRB who wish to take advantage of our free 'subscriber only' access to archived material ("individual users") and users who are authorised to access the LRB Website by subscribing institutions ("institutional users").
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Saturday, March 30. 2019
Recovery from Polymyalgia Rheumatica and Fibromyalgia?
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Sun, 25.01.2015 14:31
This does sound very credible to me, lets hope we get the o pportunity to try it for ourse lves. There is another v [...]Comments ()
Tue, 06.01.2015 22:46
David Healy summarises the cor ruption we are up against in m edical care. "Most Western countries have signed up [...]Comments ()
Fri, 24.10.2014 15:34
*Big pharma has an interest in rich people being sick Wha t profit is there in a healthy population? If everyone [...]Comments ()
Wed, 17.09.2014 16:16
Another example is Lemtrada (f ormerly known as alemtuzumab o r Campath 1-H). This was forme rly licensed as a drug t [...]Comments ()
Wed, 17.09.2014 15:58
An example is Dimethyl Fumerat e an antifungal in condemned Chinese sofas voted as the mos t allergenic molecule by [...]Comments ()
Wed, 17.09.2014 14:11
I was diagnosed with Multiple Sclerosis in 1990 at the age o f 21. My mobility had graduall y got worse over the yea [...]Comments ()
Fri, 12.09.2014 17:03
Karen Thank you for an intere sting question. There is a gre at deal of confusion out there and I totally avoid rea [...]Comments ()
Fri, 12.09.2014 16:39
Hi Dr Amir, do you think that a Forward Head posture is caus ed by incorrect jaw position i n all cases? I assume th [...]Comments ()
Fri, 05.09.2014 15:48
The description of the disease seems to change according to the drug that's being marketed . -Ray Peat, PhD Ther [...]Comments ()
Mon, 21.07.2014 19:04
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Thu, 19.06.2014 21:45
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And here the utter failure of the diagnostic 'evidence' to p rove the ludicrous 'sub-types ' of MS! PPMS vs. RRM [...]Comments ()
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For those who do not know what the two procedues in jaw reha bilitation mean: Arthrocent esis: is the clinical pr [...]Comments ()
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I saw this post on a TMJD page on Facebook and thought that I would share it here. Would y ou have any specific adv [...]Comments ()
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Hello A very interesting inqu iry! When I was learning th e Atlasprofilax method (Not fr om Atlasprofilax) my tra [...]Comments ()


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Postmenopausal bleeding (PMB) is bleeding from the vagina that happens after a woman has stopped having regular menstrual periods because of menopause. Any vaginal bleeding that occurs 12 months after a woman's last menstrual period is considered PMB.
PMB may be caused by several factors. These may include:
- Continuous hormone replacement therapy (HRT)
- Thinning and loss of elasticity of the vagina
- Inflammation of the endometrium, the lining of the uterus
- Endometrial hyperplasia, a thickening of endometrium
- Polyps, noncancerous growths on the uterus or cervix
- Infection of the uterus or cervix
- Uterine cancer
- Cervical cancer
- Fibroid tumors in the uterus or vagina
Risk Factors
Some medical conditions and medications you take can increase your chances of having PMB.
Vaginal bleeding is a symptom of PMB. Your doctor can determine what condition is causing the bleeding and whether it is serious. If you have PMB, you should see your doctor.
You will be asked about your symptoms and medical history. A physical exam will be done.
Tests will be done to find the cause of the bleeding. Tests may include:
- Transvaginal ultrasound
- Saline infusion sonohysterography
- Hysteroscopy
- MRI scan
Your doctor may need cell and tissue samples. This can be done with:
- Cervical cancer screening
- Endometrial biopsy
Talk with your doctor about the best treatment plan for you. The first priority is ruling out cancer. Treatment will depend on the findings of your tests and the cause of the bleeding. For instance, if your tests show signs of cancer, you will be referred to an oncologist, a doctor who specializes in treating cancer.
Revision Information
- Reviewer: EBSCO Medical Review Board Marcie L. Sidman, MD
- Review Date: 03/2018 -
- Update Date: 11/05/2014 -


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This metal chrome money clip and watch is made from stainless steel and measures approximately 1.25" in diameter.Miyota mechanical watch movement by Citizen.Battery included.
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Principal Proposed Uses
Taurine is an amino acid, one of the building blocks of proteins. Found in the nervous system and muscles, taurine is one of the most abundant amino acids in the body. It is thought to help regulate heartbeat, maintain cell membranes, and affect the release of neurotransmitters (chemicals that carry signals between nerve cells) in the brain.
There is no dietary requirement for taurine, since the body can make it out of vitamin B 6 and the amino acids methionine and cysteine. Deficiencies occasionally occur in vegetarians, whose diets may not provide the building blocks for making taurine.
People with diabetes have lower-than-average blood levels of taurine, but whether this means they should take extra taurine is unclear.
Meat, poultry, eggs, dairy products, and fish are good sources of taurine. Legumes and nuts don't contain taurine, but they do contain methionine and cysteine.
Therapeutic Uses
Preliminary evidence suggests that taurine might be helpful in congestive heart failure (CHF), a condition in which the heart has trouble pumping blood, which leads to fluid accumulating in the legs and lungs. 1Warning : Keep in mind that CHF is too serious for self-treatment. If you're interested in trying taurine or any other supplement for CHF, you should first consult your doctor.
There is also some evidence that taurine may be helpful for acute viral hepatitis . 2
Taurine has additionally been proposed as a treatment for numerous other conditions, including alcoholism , cataracts , diabetes , epilepsy , gallbladder disease , hypertension , multiple sclerosis , psoriasis , and stroke , but the evidence for these uses is weak and, in some cases, contradictory. 3-7 Taurine is also sometimes combined in an "amino acid cocktail" with other amino acids for treatment of attention deficit disorder , but there is no evidence as yet that it works for this purpose.
What Is the Scientific Evidence for Taurine?
Congestive Heart Failure
Several studies (primarily by one research group) suggest that taurine may be useful for congestive heart failure . For example, in one double-blind, placebo-controlled trial , 58 people with CHF took either placebo or 2 g of taurine 3 times daily for 4 weeks. 8 Then the groups were switched. During taurine treatment, the study participants showed highly significant improvement in breathlessness, heart palpitations, fluid buildup, and heart x-ray, as well as standard scales of heart failure severity. Animal research as well as small blinded or open studies in humans have also found positive effects. 9-13 Interestingly, one very small study compared taurine with another supplement commonly used for congestive heart failure, coenzyme Q 10 . The results suggest that taurine is more effective. 14
Viral Hepatitis
There are several viruses that can cause acute viral hepatitis , a disabling and sometimes dangerous infection of the liver. The most common are hepatitis A and B, although there are others (with such imaginative names as C and D).
One double-blind study suggests that taurine supplements might be useful for acute viral hepatitis. In this double-blind, placebo-controlled study, 63 people with hepatitis were given either 12 g of taurine daily or placebo. 15 (The report does not state what type of viral hepatitis they had.) According to blood tests, the taurine group experienced significant improvements in liver function as compared to the placebo group.
Acute hepatitis can also develop into a long-lasting or permanent condition known as chronic hepatitis. One small double-blind study suggests that taurine does not help chronic hepatitis. 16 For this purpose, the herb milk thistle may be better.
Safety Issues
As an amino acid found in food, taurine is thought to be quite safe. There is strong evidence that taurine is safe at levels up to 3 g per day, although higher dosages have been tested without apparent adverse effects. 17 However, maximum safe dosages of taurine supplements for children, pregnant or nursing women, or those with severe liver or kidney disease have not been determined.
As with any supplement taken in multigram doses, it is important to purchase a reputable product, because a contaminant present even in small percentages could add up to a real problem.
Revision Information
- Reviewer: EBSCO CAM Review Board
- Review Date: 12/2015 -
- Update Date: 12/15/2015 -


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Headlight Assemblies
1999-04 Ford Mustang Passenger Side Headlight$49.95
- Light Option: Smoked Style
Part #: 1ALHL02845
1999-04 Ford Mustang Driver Side Headlight$54.95
- Light Option: Smoked Style
Part #: 1ALHL02844
2001-03 Mazda Protege Passenger Side Headlight$57.95Save 38%List: $93.95 Save: $36.00
- Light Option: with Silver Bezel
Part #: 1ALHL01132
2001-03 Mazda Protege Driver Side Headlight$57.95Save 38%List: $93.95 Save: $36.00
- Light Option: with Silver Bezel
Part #: 1ALHL01131
1999-04 Ford Mustang Passenger Side Headlight$59.95Save 42%List: $102.95 Save: $43.00
- Light Option: Smoked Style
Part #: 1ALHL00684
Headlight Assemblies
What are headlights and where are they located?
Headlights or headlamps simply attach to the front of your car or truck, and light up the darkness so you can see and drive safely at night. They are a type of auto part that seem to be pretty straightforward when you initially think about them. Easy enough, right?
Well, not exactly. Headlights were a lot simpler in the past. Electric headlights replaced kerosene burning lanterns, which were not only fire hazards, but also dull and extinguishable. The electric headlight stayed lit on windy days and gave drivers better nighttime vision. By 1940, "Sealed beam" headlights with glass lenses became a requirement on all vehicles in the United States.
What are some different types of headlights?
In addition to sealed beam headlights, automakers developed more styles of headlight over the years, including halogen headlights, HID headlights, and projector headlights.
1983 was the year the headlight became a bit more complicated. The sealed beam was no longer required and plastic lenses replaced them on many cars. First, composite halogen headlights arrived, which had replaceable halogen bulbs, bringing an easy repair and the integration of corner lamps and parking lights into the headlight assembly.
The 1990s brought the next significant change with the "High Intensity Discharge" (HID) and xenon headlight technology. An HID headlight bulb is filled with xenon gas, which, with the help of an HID headlight ballast, increases the bulb's brightness and life span. Unfortunately, they come at a higher price point than the boring old sealed beam and composite halogen headlights.
Then came projector headlights. Projector headlights might use halogen or xenon bulbs, and direct light out the front of the car with the help of a small, movable metal shield. This shield is controlled by an electric motor and automatically moves when the high beam switch is activated. As you can imagine, moving parts inside a headlight assembly can lead to more problems, even in the most delicate of accidents.
When it comes down to it, headlights brighten your nighttime drive. But there are a cornucopia of shapes, sizes, and styles, depending on the vehicle they are attached to. The aftermarket headlight industry has done an amazing job of offering perfect-fitting, high-quality, non-OEM headlights at prices that any car owner can afford.
How do I know if my headlights need to be replaced?
You might need to replace your headlights if they are damaged, but also if they have cloudly or scratched lenses, or moisture buildup inside. Some of the more common reasons to replace headlights are:
- Yellow or Cloudy Lenses
- Moisture Build Up
- Sealed Beams
- Old Age
- Worn Out Appearance
Over time, plastic lenses tend to fade and lose clarity. This significantly cuts down the amount of light that can shine through. You just don't realize how much light you are missing until the new set of headlights are in place.
Cooler, moist air outside can trickle into the headlight's housings, which are vented at the top and bottom to keep any air pressure differences from cracking the bulbs and lamps. When the lens of the headlight is cooler than the air inside the housing, droplets of moisture will condense inside, leaving water on the lens. When the outside temperature rises, the moisture usually evaporates. Water can easily get inside your headlights. It can leak in through cracks, broken or improper seals, or through the back near the bulb sockets and wiring, shortening the life span of the bulbs.
When a sealed beam headlight bulb is burnt out, the entire headlight assembly needs to be replaced. Luckily, they are inexpensive and easy to replace with simple hand tools.
With age, many factory composite headlight lenses become loose and eventually fall off. The lenses can't be replaced by themselves. The entire headlight assembly must be replaced to correct this problem.
Old headlights make your nice clean car look old and worn out. If you want your car to keep its value and look its best, you just have to have clean headlights.
Headlights are one of the most important components of your vehicle; they allow you to see the road in front of you clearly during the night and in any bad weather that may arise. If they have been damaged or are not working properly, not only is your own safety at risk, but the safety of others is as well. Therefore, damaged headlights should be replaced as soon as possible.
How long do headlights last?
How long headlight bulbs last can vary a lot depending on the type of bulb and your car, as well as how much you use them. Halogen bulbs may last anywhere from 400 hours of use to about 1,000 hours. The Xenon bulbs used in HID headlights can last up to 2,000 hours of use.
Headlight lens lifespans also vary widely, depending on where and how you use your car. If you drive somewhere where a lot of road salt is used, or there's lots of dirt on the roads, your headlight lenses might get scuffed up more quickly.
Is it illegal to drive with a headlight out?
Yes, it is illegal to drive with a headlight out in most states. Most states have laws that require you to have two working headlights. If you don't, you can be pulled over and ticketed.
You can also fail a sticker inspection if one of your headlights is out.
How do I replace headlights?
How to replace headlights can vary from car to car, but a typical headlight repair may include the following steps
- Open the hood.
- Remove any other parts that keep you from accessing the headlight housing bolts.
- Remove the screws or bolts holding the headlight housing in place.
- Disconnect the wiring harnesses from the headlight bulbs.
- Pull the headlight off of the vehicle.
- Put the new headlight into place on the vehicle.
- Connect the wiring harnesses to the headlight bulbs.
- Fasten the bolts or screws to the headlight housing.
- Aim the headlights to be properly aligned.
- Close the hood.
These may include air intake parts or radiator hoses, for example.
You may need a service manual to learn the process for aiming your car's headlights. Replacing one headlight at a time may make aiming the headlight easier.
How do I replace headlight bulbs?
How to replace you headlight bulbs can vary from car to car. You may be able to replace the bulbs with the headlight in place, or you may have to remove the headlight from the car first. Follow the steps above if you must remove the headlight. A typical headlight bulb replacement may include the following steps:
- Wear gloves to avoid fouling the bulbs.
- Open your hood.
- Remove any parts obstructing your access to the headlight bulbs.
- Twist the bulbs sockets out of the headlight.
- Pull the bulbs off the sockets.
- Push the new bulbs onto the sockets
- Twist the sockets into the headlight housing
- Close the hood.
Oil from your skin can make your headlight bulbs burn out faster.
Generally, air intake parts or radiator hoses can be blocking access to your headlights.
Should I replace both headlights at once?
It is a good idea to replace headlights as a pair. Even if one is damaged, the other may be duller than you realize. Replacing the headlights together insures that they provide equal illumination. It also makes your car look better. Your car won't look its best with one shiny new headlight and one cloudy one.
How much do headlights cost?
Headlights generally cost between $200 and $300 dollars, depending on the model of your car. The labor cost of a headlight replacement can range from about $100 to $200, depending on your model, and whether you have the work done at an independent shop or a dealership.
Headlight bulbs range from $15 to $20, with labor costs around $75 to $90.
Need Headlights?
At 1A Auto you'll find aftermarket replacement headlight assemblies of all types and styles including xenon, HID, projection, halogen, smoked, tinted, LED and more. Headlights from 1A Auto have the following features:
- DOT (U.S. Dept. of Transportation) and SAE (Society of Automotive Engineers) approved
- Direct Replacement
- Built to strict quality control standards
For more detailed information about headlights, the different types, how they each work, and more, check out our in-depth guide on replacement headlights.
Same Day Shipping
In stock orders ship same day when ordered by 2pm ET. Need your part faster? Choose expedited shipping at checkout.
Guaranteed to Fit
Our team of auto experts work hard to provide you with the highest quality, direct fit replacement auto parts. We know not all auto parts are created equal. This is why we enforce a strict level of product standards and sourcing with every part.
USA Customer Support
Our goal is to exceed our customers' expectations every day. We are a team of passionate auto enthusiasts who are here to help. If you have a question about our parts or a repair contact us.


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A risk factor is something that increases your likelihood of getting a disease or condition.
It is possible to develop BPH with or without the risk factors listed below. However, the more risk factors you have, the greater your likelihood of developing BPH. If you have a number of risk factors, ask your healthcare provider what you can do to reduce your risk.
The three primary risk factors for BPH are:
Age —The risk of BPH increases with age, beginning at about age 40. The incidence increases with age—50% by age 50 and 80% by age 80.
Ethnic background —The risk of BPH begins to rise in African American men about 5 years earlier than it does for Caucasian American men. This condition is less common among men living in Asian countries.
Gender —BPH occurs only in men.
Studies have associated BPH with:
- Metabolic syndrome —A condition marked by elevated blood pressure, cholesterol, blood glucose, and body weight. Excess weight centered around the midsection is of particular concern.
- Obesity
- Lipid disorders
- Diet high in fats and red meat
Revision Information
- Reviewer: EBSCO Medical Review Board Adrienne Carmack, MD
- Review Date: 09/2018 -
- Update Date: 09/17/2014 -


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A doctor guides small robotic arms through several tiny keyhole incisions. This allows for greater range of movement than a doctor's hand.
Reasons for Procedure
Robot-assisted surgery is considered for procedures that:
- Require precision
- Do not require open access, especially laparoscopic procedures
Performing surgery in this way may result in:
- Less scarring
- Reduced recovery times
- Less risk of infection
- Less blood loss
- Reduced trauma to the body
- Shorter hospital stay
- Faster recovery
Many types of surgery, including pediatric surgery, can now be done with the assistance of a robot, including:
- Adrenalectomy—removal of adrenal gland
- Cholecystectomy—removal of the gallbladder
- Bariatric—procedure to treat obesity and reduce the size of the stomach
- Heller myotomy—procedure on the lower esophageal sphincter
- Nissen fundoplication—treatment for severe heartburn
- Pyloroplasty
- Colectomy—removal of the colon
- Appendectomy—removal of the appendix
- Hernia repair
- Esophagectomy—removal of the esophagus
- Thymectomy—removal of the thymus gland
- Mediastinal tumor resection—removal of tumors in the chest cavity
- Lobectomy—surgical removal of a lung
- Coronary artery bypass surgery (CABG)
- Atrial septal defect repair
- Mitral valve repair
- Hysterectomy—removal of the uterus
- Myomectomy—removal of uterine fibroids
- Nephrectomy—removal of the kidney
- Radical prostatectomy—removal of the prostate
- Cystectomy—removal of the bladder
Possible Complications
Problems from the procedure are rare, but all procedures have some risk. Your doctor will review potential problems, like:
- Damage to nearby organs or structures
- Infection
- Bleeding
- Anesthesia-related problems
- The need to switch to traditional surgical methods such as traditional laparoscopic or open surgery
Some factors that may increase the risk of complications include:
What to Expect
Prior to Procedure
Depending on the reason for your surgery, your doctor may do the following:
- Physical exam
- Blood tests
- Chest x-ray
- Ultrasound
- CT scan
- MRI scan
Leading up to the surgery:
- Talk to your doctor about your medications. You may be asked to stop taking some medications up to 1 week before the procedure.
- Take antibiotics if instructed.
- Follow a special diet if instructed.
- Shower the night before using antibacterial soap if instructed.
- Arrange for someone to drive you home from the hospital. Also, have someone to help you at home.
- Eat a light meal the night before. Do not eat or drink anything after midnight.
Depending on the type of procedure that you have, you may be given:
- General anesthesia—blocks pain and keeps you asleep through the surgery
- Local anesthesia with sedation—just the area that is being operated on is numbed
Description of the Procedure
Several small keyhole openings will be cut in the skin near where the surgery will take place. In most cases, a needle will be used to inject carbon dioxide gas into the surgical area. This gas will make it easier for the doctor to see internal structures. Next, a small camera called an endoscope will be passed through 1 of the incisions. The camera will light, magnify, and project an image of the organs onto a video screen. Then robotic arms holding instruments for grasping, cutting, dissecting, and stitching will be inserted through the holes.
While sitting at a console near the operating table, the doctor will use lenses to look at a magnified 3-D image of the inside of the body. Another doctor will stay by the table to adjust the camera and tools. The robotic arms and tools will be guided by movements of the surgeon. Lastly, the tools will be removed and stitches or staples will be used to close the area.
How Long Will It Take?
Usually 1-2 hours or less, depending on the procedure
How Much Will It Hurt?
Anesthesia will prevent pain during surgery. Pain and discomfort after the procedure can be managed with medications. You may also feel discomfort from the gas used during the procedure. This can last up to 3 days.
Average Hospital Stay
This procedure is done in a hospital setting. The usual length of stay is a few days. Your doctor may choose to keep you longer if you have any problems.
Post-procedure Care
While you are recovering at the hospital, you will:
- Be encouraged to walk with assistance soon after surgery.
- Receive guidelines on what you should eat and what activities you can do. Depending on your procedure, you should be able to go back to your normal activities in a few weeks.
- Participate in any physical therapy or rehabilitation.
Call Your Doctor
Call your doctor if any of these occur:
- Signs of infection, including fever and chills
- Redness, swelling, increasing pain, excessive bleeding, or discharge from an incision site
- Cough, shortness of breath, chest pain, or severe nausea or vomiting
- Pain, burning, urgency, frequency of urination, or persistent bleeding in the urine
- Pain and/or swelling in your feet, calves, or legs, or sudden shortness of breath or chest pain
- Constipation or diarrhea
- New or unexpected symptoms
If you think you have an emergency, call for emergency medical services right away.
Revision Information
- Reviewer: EBSCO Medical Review Board Donald W. Buck II, MD
- Review Date: 03/2018 -
- Update Date: 05/29/2014 -


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AOL wants 2,500 employees to step forward for volunteer layoffs.
Today it sent employees an email saying what they would get if they volunteered for the layoff today versus what they would get if they are asked to leave in Q1 of 2010.
It breaks down:
- SVPs get 9 months for volunteering versus 4 in Q1.
- VPs get 6 vs 4
- Director is 4 vs 2
- Sub-director is 3 vs 1
The package covers severance, cobra, and outplacement.
Here's the email:


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