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Application of these mechanical concepts of understanding the function of the mechanical subsystems will be important to combine all parts into a functional buy 50 mg nitrofurantoin amex, whole musculoskeletal system discount 50 mg nitrofurantoin. Muscle Mechanics Energy Production Based on the understanding of Newtonian physics, a change in movement state cannot occur unless there is an output of energy. In the human body, this output of energy occurs through the muscles, which are constructed of small subunits called sarcomeres (Figure 7. Sarcomeres have actin and myosin subunits that form chemical bonds, causing the actin and myosin sub- units to overlap when they are stimulated by electrical depolarization pro- duced by the motor neuron. The chemical energy needed for this shortening action of the sarcomere may be produced by aerobic metabolism, where Figure 7. The microanatomy of the muscle fiber starts with sarcomeres, which are the building blocks of the muscle fibers. The sar- comeres are made of thin actin molecules that slide over the thicker myosin. With max- imum elongation, there is only a small area of overlap. At rest, the fibers have approxi- mately 50% overlap, and at full contraction, there is complete overlap. The chemical re- action causing this overlapping of the actin and myosin is the force-generating mecha- nism of muscle. In cross section, the fibers are stacked to provide a maximum number of contacts of the actin to the myosin fibers. The sarcomeres are then com- bined end to end to form myofibrils, which are combined parallel to each other to form muscle fibers. Many muscle fibers are then combined into a single muscle attached at each end to a tendon. Alternatively, en- ergy can be produced by anaerobic metabolism using glycolysis of glucose in which ATP and lactic acid are generated as by-products. Another mechanism allows the enzymatic breakdown of phosphocreatine with the production of ATP and creatine. The chemical directly used by the sarcomere is ATP, which binds to the myosin and provides the energy for the cross-bridging to actin. The chemical details of sarcomere function and the energy production are well understood from a biochemical perspective; however, this energy pro- duction process is seldom a basic problem for children with CP. Sarcomeres are then combined into muscle fibers; the specific diameter of the fiber is determined by how many sarcomeres are placed together in the transverse plane (Figure 7. The diameter of muscle fibers varies from approximately 20 micrometers (µm) in hand intrinsic muscles to 55 µm in leg muscles. Many muscle fibers are com- bined into one motor unit, which is controlled by a single motor neuron. The number of muscle fibers per motor neuron varies from approximately 100 in hand-intrinsic muscles to 600 in the gastrocnemius muscle. Thus, a hand- intrinsic muscle may contain approximately 100 motor units and the gas- trocnemius contains approximately 1800 motor units. The muscle fibers in each individual motor unit are dispersed throughout the whole body of the muscle. The length of the muscle fiber is determined by the number of sarcomeres placed end to end. This muscle fiber length determines the muscle excursion length and therefore the active range of motion of the joint. For example, if the gastrocnemius usu- ally produces 60° of active ankle joint range of motion, and the muscle loses 50% of its fiber length, it can generate only 30°of active ankle range of motion. The large number of motor units present mutes this all-or-nothing response in the whole muscle. Therefore, the level of muscle force that can be generated is based on how many motor units can contract simultaneously. Force Production The amount of force that a muscle can generate is based on the cross- sectional area of the muscle; however, the amount of work and power a mus- cle can generate is based on the total mass of the muscle.
The mean changes in UPDRS of 24% in the ropinirole group and 3% in the placebo group reached statistical significance generic 50 mg nitrofurantoin fast delivery. Time to levodopa significantly differed best 50 mg nitrofurantoin, with 11% of ropinirole subjects and 29% of placebo subjects requiring additional therapy. Requirement for levodopa therapy for the ropinirole subjects was 16, 27, and 40% at 1, 2, and 3 years, respectively (1). Studies have also been completed in de novo patients randomized to ropinirole or placebo (ropinirole 056 study) and followed by PET scanning (REAL-PET) (3,33). The 5-year clinical trial randomized 268 subjects to ropinirole (n ¼ 179) or placebo (n ¼ 89) in a 2:1 fashion, allowing add-on levodopa at the discretion of the investigator. Eighty-five subjects in the ropinirole group (47%) and 45 subjects in the levodopa group (51%) completed the study. In the ropinirole group 29 of the 85 patients (34%) received no levodopa supplementation at 5 years. The analysis of the time to dyskinesia showed a significant difference in favor of ropinirole, and at 5 years the cumulative incidence of dyskinesias, regardless of levodopa supplementation, was 20% in the ropinirole group and 45% in the levodopa group. The average dosage for levodopa supplementation was 427 mg/ day. The subjects randomized to levodopa received an average of 753 mg/ day. Recently, the results of a PET analysis comparing ropinirole to levodopa have been reported (REAL-PET) (3). This 2-year randomized trial found a statistically significant difference in striatal uptake when comparing ropinirole 13% to levodopa 20%. Clinical evaluation of these subjects found that 14% of the ropinirole group vs. In this review, no differences were seen between groups, and a parallel rate of sustained efficacy without dyskinesia was seen. A 6-month, placebo-controlled trial of 149 subjects with advanced PD randomized to ropinirole (n ¼ 95) or placebo (n ¼ 54) followed for levodopa dosage and off-time reduction was conducted. In this study, levodopa dosage was reduced an average of 31% in ropinirole subjects compared to 6% in placebo subjects. Off-time was reduced by 12% in the ropinirole group and 5% in the placebo group, a difference in off-time of slightly over one hour per day (36). Other Dopamine Agonists Cabergoline is a once-daily, ergot-derived, dopamine agonist available in the United States for the treatment of hyperprolactinemia. It has been demonstrated to be effective in PD, but is prohibitively expensive in the United States. Cabergoline has been evaluated in de novo and advanced PD populations. In a double-blind, 2:1 placebo-controlled trial of 188 subjects taking levodopa, the addition of cabergoline allowed for an 18% reduction in levodopa, with a 16% improvement in motor scores (37). Clarke and Deane have compared cabergoline to bromocriptine in a meta-analysis of five randomized, double-blind, parallel group studies in 1071 patients (35). Cabergoline produced benefits similar to bromocriptine in off-time reduction, motor impairment and disability ratings, and levodopa dose reduction over the first 3 months of therapy. Dyskinesia and confusion were increased with cabergoline, but otherwise the frequency of adverse events and withdrawals from treatment were similar with the two agonists. Rotigotine is a novel DA that is unique in that it is delivered through a skin patch transdermal system. In one multicenter phase II b trial, 316 patients were randomized to placebo or active drug in a 1:4 ratio and followed by UPDRS for 4 weeks (38). In this dose-finding study, statistical improvement in UPDRS activity of daily living and motor scores were seen at 9, 13. Positive responder rates (>20% UPDRS change) increased with dosage; responder rates were as follows: placebo, 29%; 4. COMPARISONS BETWEEN DOPAMINE AGONISTS At this time 15 comparative trials between DA are known: Tan and Jankovic have summarized these studies and report conversion factors of 10:1 for bromocriptine to pergolide, 1:1 for pergolide to pramipexole, 1:6 for pergolide to ropinirole, and 10:6 for bromocriptine to ropinirole (6).
Ethanol is an inhibitor of the phenobarbital-oxidizing P450 system order nitrofurantoin 50 mg fast delivery. When large amounts of ethanol are consumed purchase nitrofurantoin 50 mg on line, the inactivation of phenobarbital is directly or indi- rectly inhibited. Therefore, when high doses of phenobarbital and ethanol are consumed at the same time, toxic levels of the barbiturate can accumulate in the blood. CHAPTER 25 / METABOLISM OF ETHANOL 463 Although induction of CYP2E1 increases ethanol clearance from the blood, it has As blood ethanol concentration negative consequences. Acetaldehyde may be produced faster than it can be metab- rises above 18 mM (the legal intox- olized by acetaldehyde dehydrogenases, thereby increasing the risk of hepatic injury. In addition, cytochrome P450 enzymes are capable of generating free radicals, and central nervous system are affected. Induction of CYP2E1 increases the rate of ethanol clearance from the blood, thereby E. Variations in the Pattern of Ethanol Metabolism contributing to increased alcohol tolerance. However, the apparent ability of a chronic The routes and rates of ethanol oxidation vary from individual to individual. Dif- alcoholic to drink without appearing inebri- ferences in ethanol metabolism may influence whether an individual becomes a ated is partly a learned behavior. Factors that determine the rate and route of ethanol oxidation in individuals include: • Genotype—Polymorphic forms of alcohol dehydrogenases and acetaldehyde dehydrogenases can greatly affect the rate of ethanol oxidation and the accumu- lation of acetaldehyde. CYP2E1 activity may vary as much as 20-fold between individuals, partly because of differences in the inducibility of different allelic variants. After chronic consumption of ethanol, gastric ADH decreases in both men and women, but the gender differences become even greater. Gender differ- ences in blood alcohol levels also occur because women are normally smaller. Furthermore, in females, alcohol is distributed in a 12% smaller water space because a woman's body composition consists of more fat and less water than that of a man. Small amounts of ethanol are metabo- lized most efficiently through the low Km pathway of class I ADH and class II ALDH. Little accumulation of NADH occurs to inhibit ethanol metabolism via these dehydrogenases. However, when higher amounts of ethanol are consumed in a short period, a disproportionately greater amount is metabolized through MEOS. MEOS, which has a much higher Km for ethanol, functions principally at high concentrations of ethanol. A higher activity of MEOS would be expected to correlate with tendency to develop alcohol-induced liver disease, because both acetaldehyde and free radical levels would be increased. The Energy Yield of Ethanol Oxidation The ATP yield from ethanol oxidation to acetate varies with the route of ethanol metabolism. If ethanol is oxidized by the major route of cytosolic ADH and mito- chondrial ALDH, one cytosolic and one mitochondrial NADH are generated with a maximum yield of 5 ATP. Oxidation of acetyl CoA in the TCA cycle and electron transport chain leads to the generation of 10 high-energy phosphate bonds. How- ever, activation of acetate to acetyl CoA requires two high-energy phosphate bonds (one in the cleavage of ATP to AMP pyrophosphate and one in the cleavage of pyrophosphate to phosphate), which must be subtracted. Thus the maximum total energy yield is 13 moles of ATP per mole of ethanol. In contrast, oxidation of ethanol to acetaldehyde by CYP2E1 consumes energy in the form of NADPH, which is equivalent to 2. Thus, for every mole of 464 SECTION FOUR / FUEL OXIDATION AND THE GENERATION OF ATP At Ivan Applebod's low level of ethanol metabolized by this route, only a maximum of 8. The overall energy yield of 13 ATP per ethanol molecule II. TOXIC EFFECTS OF ETHANOL METABOLISM accounts for the caloric value of ethanol, approximately 7 Cal/g. However, chronic Alcohol-induced liver disease, a common and sometimes fatal consequence of consumption of substantial amounts of alco- chronic ethanol abuse, may manifest itself in three forms: fatty liver, alcohol-induced hol does not have the effect on body weight hepatitis, and cirrhosis.
This is ideally done in a multidisciplinary team with therapist buy 50mg nitrofurantoin, rehabilitation engineer generic nitrofurantoin 50 mg otc, par- ent, and physician. This process is especially true for very sophisticated power chairs with multiple features, which may cost as much as $30,000. Rehabilitation Techniques 827 contractures; he is independent in power wheelchair mobility; he is dependent for transfers; he is verbal in communication; and cognitively he is age appropriate. His current wheelchair is a Quickie P200 power wheelchair, which is three years old. Due to growth and weight gain, this system no longer accommo- dates Kevin's seating and mobility needs. His P200 is a 17-inch wheelchair and currently Kevin's hip measurement is 19 inches. It is evident that this wheelchair no longer accommodates his needs. The seating goals for Kevin are to increase mobility, increase efficiency, en- hance function, maintain posture, increase independence, protect skin, provide comfort, and provide safety. Upon evaluation, the seating team recommends the following be prescribed for Kevin: Action Arrow wheelchair with 4-pole motors and weight-shifting power tilt-in-space; 14-inch wheels with flat free fillers and rubber knobby tires; Q-tronics electronics – joystick with 1/8 inch jacks; swing-away mount on right side; 24 NF gel batteries; low seat-to-floor height; 70 degree hangers with angle-adjustable footplates; height-adjustable desk length on right and full length on left; clear tray with top drop hardware and tray support extension and joystick cutout; Cloud cushion; AEL flat swing-away laterals 5×6; solid curved I-back; small curved OttoBock headrest with hardware; TRCM with mounting bracket; TASH C5 adapter; TASH microlite switch; color: black with twilight. Specific components and indications: Basic Motorized • Unable to ambulate or propel a manual Wheelchair wheelchair • Has functional use of one UE • Low/decreasing endurance Motorized W/C with • Special switch configuration necessary due to adjustable electronics upper extremity weakness • Increased sensitivity adjustability to decrease spasms of client and/or allow use of ECU with w/c • Capability to adjust speed, excel; to allow better control and safety in use TRCM w/TASH switch • Alternate switch for tilting due to limited strength, especially when in tilt and working against gravity • Maintains constant access to tilt regardless of degree of tilt High strength • Strong base of support for tilt • Outdoor terrain Power tilt • Independent weight shift for position change • Pressure relief • Reduce/eliminate shear • Reduce spasms • Personal hygiene Adjustable height arm • Support to tray at right height • Upper body support and balance • Ease of transfer Angle-adjustable • Ankle contractures footplates • Ankle braces • Reduce extensor thrust in LEs • Knee contractures – prevent feet from resting on standard footplate Solid seat • Pelvic stability • Avoid sling effect, adduction of knees 828 Rehabilitation Techniques Cloud cushion • Pressure relief for bony prominences • Contour for pelvic stability Jay back • Pressure relief along spine • Min/mod lateral and lumbar support and contour • Built-in capability for growth Solid back • Upright posture • Prevent/minimize kyphosis • Trunk stability Laterals • Encourage midline trunk position and correct/delay scoliosis • Compensate for lack of trunk control • Safety • Assist with transfer, locks for strength Headrest • Poor head control due to low tone • Active flexion/hyperextension of head • Posterior and/or lateral support • ATNR • Safety in transport • Facilitate breathing Tray (clear) • Upper arm and trunk support • Functional surface for schoolwork • Inability to access desks, tables, etc. We hope that you will be able to accommodate these needs in an expedient manner. Thank you for your co- operation and assistance in this matter. TMCurriculum is an activity-based curriculum designed to teach individuals basic functional motor skills needed for adult life. These skills allow them to enjoy a more inclusive lifestyle because movement is an integral part of everyday life. People with physical disabilities often require assistance to participate in these everyday activities, such as moving to the bed or bath- room, to school, or to their place of work. The MOVE curriculum provides a framework for teaching the skills necessary for individuals with disabilities to gain greater physical independence. It combines functional body move- ments with an instructional process designed to help people acquire increas- ing amounts of independence in sitting, standing, and walking. Rehabilitation Techniques 829 Linda Bidabe, founder and author of the MOVE curriculum, realized the need for a functional mobility curriculum when she observed that 21-year- old students were graduating from her school with fewer skills than they had when they entered school. She believed that the "developmental model" was not meeting the needs of students with severe disabilities because these stu- dents learned skills at a very slow rate and would take years to develop some of the early developmental skills such as rolling or prone propping on el- bows. Therefore, the students would never accomplish functional mobility skills in sitting, standing, and walking. This includes those with both significant motor dis- abilities and mental retardation. Whether in a special school or a regular classroom setting, MOVE provides the student increased opportunities to participate in life activities with their peers without disabilities. Progress in the program can help reduce the time needed for custodial care, increase the child's self esteem, and promote acceptance by peers. Contraindications to consider before starting the MOVE curriculum in- clude circulatory disease, respiratory distress, brittle bones, muscle contrac- tures, curvature of the spine, hip dislocation, foot and ankle abnormalities, pain or discomfort, or a head that is too large to be supported by the neck. Medical or physical therapy consultation is recommended for any student with possible contraindications to obtain clearance for the exercise and weight- bearing activities. Exclusion from the program is limited to those individuals whose medical needs contraindicate the need to sit, stand, or walk. The MOVE program is based upon the teaming of special education in- struction with therapeutic methods and includes ecologic inventory, priori- tization of goals, chronologically age-appropriate skills, task analysis, prompts for partial participation, prompt reduction, and the four different stages of learning: acquisition, fluency, maintenance, and generalization. In step one, the student participates in the Top-Down Motor Milestone(TM) Test that evaluates his or her ability in 16 basic motor skills that are necessary for functioning in the home and community. The motor skills are age appropriate and based on a top-down model of needs rather than the traditional developmental programs based on sequential motor skills acquisition of infants. Following the test, the student, parents, and/or caregivers are briefly in- terviewed in step two, to determine activities important to the family at the present time and in the future.
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Do You Love Your Aorta?
Dr. Kahn's practice is full of patients with enlarged aorta. Do you know if yours is healthy? If you have had an echo, CT, or MRI of the heart you do know that. This week we discuss why a healthy aorta is a great joy on this edition of Heart Doc VIP on Empower Radio.
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We are lucky – on the whole. In the modern world, risk has been squashed and repressed wherever it appears. The big exception is in our savings, which for many people is now the riskiest part of their lives. When we try to preserve our wealth we immediately become medieval peasants, helpless victims of an implacable fate. Two hundred years ago, Nathan Mayer Rothschild, the greatest banker of his day, said that it was ten times harder to preserve wealth than it was to make it in the first place. Not much has changed.
Unfortunately, we have to take risks. We have no choice, because the cost of not doing so has become immense. The entry fee to safe havens is prohibitive. Bond markets are behaving like an insurance salesman who wants to charge you more to insure your house than it would cost to rebuild. Safety guarantees loss.
If we want a reasonable prospect of real returns, we have to invest in equities; and that means having to cope with uncertainty. As John Maynard Keynes, the great economist put it in the 1930s: 'The modern holder of quoted equities requires much more nerve, patience and fortitude than the holder of wealth in other forms'. The purpose of this piece is to instil in you, Dear Reader, that Nerve, Patience and Fortitude. The evidence is clear: it is worth it – and anyway we have no choice.
It seems to us that the greatest enemy of successful investment is 'Events'. We are all participants in an endless parade of happenings, which, being human, we continuously try to integrate into our world view. There are too many events for us to treat them critically, or test them for relevance. With our wealth at stake, we adopt a semi-conscious policy of worrying about as much as possible, and discounting as little as we can – especially if it sounds alarming. There is plenty of academic evidence for this. It is best summarised in Daniel Kahneman's excellent book 'Thinking, Fast and Slow'. He shows how we instinctively default to the most recent or striking piece of evidence, and that our urge to leap to conclusions overwhelms our better, rational selves.
Modern media make the problem much worse, of course. 'News' is crafted to grab our attention; it is not created spontaneously by the world. It is said that in 1936 a BBC announcer solemnly announced over the wireless: 'Good evening. It is six o'clock. There has been no news today'. Those days are long gone.
So, if news and events are our enemies, how do we cope with them? The first step is to regard them with the suspicion they deserve, and to be more discriminating in how we react. From the investor's point of view, most events can be put into one of three categories: a large proportion is simply irrelevant, even though it may look vital and pressing; some is misleading, sending us haring off in the wrong direction; but some is boring, underreported – and very helpful.
The rest of this paper will concentrate on giving examples of all three types of events in the hope that it will help fellow investors make some money and ignore the siren calls enticing them onto the rocks. It may also help them sleep better at night.
Most news is irrelevant and can be safely ignored. Especially pointless are the frequent predictions of things which cannot be predicted. The forecasting records of even the best economists are very poor. We know this but we still listen to them. We are like ancient Romans, who peered at chickens' livers before every battle to see who would win. We would be better off assuming that the economy does OK most of the time. Experiments show that in complicated matters mean reversion is a better tool for prediction than listening to experts.
Similarly, the huge amount of effort devoted to interpreting short-term market movements is largely pointless. The market is not a person; it does not have reasons or intentions. Its wanderings are the residual of countless opposing forces. It is not 'Trying to tell us something'. Its meanderings may well provide us with opportunities to buy or sell, but it is much easier to behave rationally if we do not believe that a fall in prices betrays some hidden horror. Similarly, a rise in prices does not mean that Santa Claus is on his way.
A great deal of political, social and global reportage is irrelevant to us too. We are trying to be good investors, not emperors. We are not responsible for the big picture; we only have to buy what we really like. Very often a story will draw us in. We become 'experts' on matters such as Greek public finance, which held no charms for us before, but which assume a disproportionate importance in our minds because we keep hearing about it. We are unwilling to write off this tediously won knowledge, so we think it must be important.
The point is not that everything is irrelevant, but that most investors are too exposed to random buffetings by forces that have no more influence on their portfolios than the gale outside their windows (this is written in Scotland). They should wrap up.
Being somewhat contrarian, having a preference towards 'Leaning against the Wind', as Keynes put it, is a characteristic of all good investors. This can make them difficult in the home – they need understanding wives and husbands – but it helps them make money. For the contrarian, nothing is more exciting than the misleading news item.
Good news is routinely presented as bad. For example, China's decision to raise rates to combat inflation is generally received badly. But surely inflicting pain in that way is exactly the right thing to do? If a company is happy to defer profits by investing heavily today, is that really bad news? It is all a matter of having a sensible time scale. It is right to take some pain now if the eventual consequence is positive. The crisis in Europe has been a perfect example of this. Imposing Germanic fiscal discipline on a whole continent was always going to be a gradual, lengthy process. The point is that we are heading in the right direction, but almost all commentators focus on how painful each step is.
Occasionally things are worse than they look. This usually happens in times of bubbly exuberance. The most obvious examples come from the financial sector. Banks tend to write off all the bad loans they can, but this has the perverse consequence that when times are really bad and their balance sheets are weak, banks will often refrain from writing off bad loans and consequently report excessive profits. These profits are really a sign of weakness. An increase in write offs and a rise in bankruptcies are signs that the healing process has started.
The moral here is to question the conventional interpretation put on the news, especially bad news, which always gets a wider airing from the media than the good variety. If you are feeling particularly fed up about your investments, ask yourself this question: If you were a historian of the future looking back over the grand sweep of financial history, what would the really great buying opportunities of history have felt like at the time? The answer is, 'Pretty Grim.' It is always darkest before the dawn, and the successful contrarian is aware how misleading conventional opinion can be.
We are not arguing that the successful investor should ignore everything and hide away from all worldly contact: no one admires the investment skills of the Desert Fathers. The point is that the world as it is presented to us is misleading, unsettling and deeply unhelpful from an investor's point of view. We should be aware of this bias and remember that the really useful news is often ignored.
The simplest form of general ignorance takes place when facts arise which do not fit in with the conventional story. The fall in Italian long-term interest rates has been resolutely ignored by those who confidently predict a euro disaster; the facts do not fit the story. Even market prices can be a better indicator than economic statistics, if the two persistently point in different directions; and the popularity of the incumbent political leader gives you a better reading than most official measures about how well an economy is performing.
The news we are fed has a strong negative and sensationalist tilt. As the great American historian David Landes has pointed out, ultimately the only satisfaction the pessimist has is to say, 'I told you so'. The optimist is always on the lookout for the right kind of news. On the whole, things work out in the end because people adapt their behaviour. This is something that conventional analysis has a big problem with: it presents a static picture of a world in which unsustainable behaviour is always extrapolated until we run off the edge of the cliff. In the real world, people just do something else or invent something. The extrapolation fallacy is especially common in financial matters. It is obvious that America is never going to run out of dollars, any more than a man with a functioning spigot will run out of water. The naive extrapolators cannot see this.
Conventional news ignores the benign adaptations which help us survive, because they are gradual and quiet. This is especially true of our responses to price signals – perhaps because, on the whole, the news media find companies opaque and hard to understand. Investors would be well advised just to assume that big price changes will always lead to changes in supply and demand, and look for the early evidence for this in companies' behaviour. The most glaring example of this is America's imminent self sufficiency in hydrocarbons, and the discovery of huge new oil fields in Brazil, Canada, and Australia, combined with a sharp increase in the efficiency of energy use. These changes are all the consequence of the human energy released by high oil prices over several years, but the massive implications are only gradually being recognised.
Technological change is underplayed too, because its consequences are also gradual. To take one example among many: we have barely begun to understand the implications of the internet for a wide range of service industries. Can high streets and malls survive in anything like their current form? Do professional services have to be carried out in high wage countries? Do we have to travel to work? It does not take any specialised technological knowledge to play this game: the inventions which set these changes in motion were made years ago.
If all else fails and you feel the weight of events pressing too hard; if you are under pressure to make a decision you know you will regret, there is only one answer: Travel. Take a vacation somewhere without broadband. When you eventually return, you will find that the events which oppressed you have passed by and been forgotten.
The views expressed in this article are those of the author and do not necessarily reflect those of Baillie Gifford. They should not be considered as advice or a recommendation to buy, sell or hold a particular investment. They reflect personal opinion and should not be taken as statements of fact nor should any reliance be placed on them when making investment decisions.
This communication was produced and approved on the stated date and has not been updated subsequently. It represents views held at the time of writing and may not reflect current thinking.
Baillie Gifford & Co and Baillie Gifford & Co Limited are authorised and regulated by the Financial Conduct Authority (FCA). Baillie Gifford Life Limited is authorised by the Prudential Regulation Authority (PRA) and regulated by the FCA and the PRA. Baillie Gifford & Co Limited is a unit trust management company and the OEICs' Authorised Corporate Director.
Baillie Gifford Overseas Limited provides investment management and advisory services to non-UK Professional/Institutional clients only. Baillie Gifford Overseas Limited is wholly owned by Baillie Gifford & Co. Baillie Gifford & Co and Baillie Gifford Overseas Limited are authorised and regulated by the FCA in the UK.
Persons resident or domiciled outwith the UK should consult with their professional advisers as to whether they require any governmental or other consents in order to enable them to invest, and with their tax advisers for advice relevant to their own particular circumstances.
Baillie Gifford Asia (Hong Kong) Limited 百利亞洲(香港)有限公司 is wholly owned by Baillie Gifford Overseas Limited; and holds a Type 1 licence from the Securities & Futures Commission of Hong Kong to market and distribute Baillie Gifford's range of UCITS funds to professional investors in Hong Kong. Baillie Gifford Asia (Hong Kong) Limited 百利亞洲(香港)有限公司 can be contacted at 30/F, One International Finance Centre, 1 Harbour View Street, Central, Hong Kong, Telephone +852 3756 5700
Baillie Gifford Overseas Limited is licensed with the Financial Services Commission in South Korea as a cross border Discretionary Investment Manager and Non-discretionary Investment Adviser.
This material is provided on the basis that you are a wholesale client as defined within s761G of the Corporations Act 2001 (Cth). Baillie Gifford Overseas Limited (ARBN 118 567 178) is registered as a foreign company under the Corporations Act 2001 (Cth). It is exempt from the requirement to hold an Australian Financial Services License under the Corporations Act 2001 (Cth) in respect of these financial services provided to Australian wholesale clients. Baillie Gifford Overseas Limited is authorised and regulated by the Financial Conduct Authority under UK laws which differ from those applicable in Australia.
Baillie Gifford Overseas Limited is registered as a Foreign Financial Services Provider with the Financial Sector Conduct Authority in South Africa.
Baillie Gifford International LLC is wholly owned by Baillie Gifford Overseas Limited; it was formed in Delaware in 2005. It is the legal entity through which Baillie Gifford Overseas Limited provides client service and marketing functions in America as well as some marketing functions in Canada. Baillie Gifford Overseas Limited is registered as an Investment Adviser with the Securities & Exchange Commission in the United States of America.
All investment strategies have the potential for profit and loss, your or your clients' capital may be at risk. Past performance is not a guide to future returns.
Any stock examples and images used in this presentation are not intended to represent recommendations to buy or sell, neither is it implied that they will prove profitable in the future. It is not known whether they will feature in any future portfolio produced by us.
Any individual examples will represent only a small part of the overall portfolio and are inserted purely to help illustrate our investment style.
This document contains information on investments which does not constitute independent research. Accordingly, it is not subject to the protections afforded to independent research and Baillie Gifford and its staff may have dealt in the investments concerned.
All information is sourced from Baillie Gifford & Co and is current unless otherwise stated.
The images used in this document are for illustrative purposes only.
Ref: 32254 ALL WE 0094


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Viola Bows
Viola BowEugene Sartory, Silver/Ebony
Certified by Paul Childs, Montrose, N.Y., May 2012.
Viola BowEmile August & Emile Francois Ouchard, Mirecourt circa 1930. silver/ebony
A very fine collaborative viola bow by the father and son, E.F. and E.A. Ouchard. The round stick is made from golden brown pernambuco wood. The ebony frog is silver…
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Viola BowJ.J. Martin, Mirecourt ca. 1875
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Viola BowJohannes S. Finkel, Brienz, gold & tortoiseshell
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Viola BowNoel Burke, Carlow, Ireland, Gold/Ebony
Viola BowMarcel LaPierre, Silver/Ebony
The stick is made from medium brown pernambuco wood and is in the octagon form. The tip plate is silver, the winding is silver tinsel, the frog is ebony with…
Viola BowThomas Jacques Holder, Silver/Ebony
Viola BowFrancois Lotte, Nickel Silver/Ebony
Viola BowPaul Bisch Brand, Silver/Ebony
Viola BowC. Hans-Karl Schmidt, Engraved Silver/Ebony
Viola BowMorizot Freres, Branded "P. BISCH – PARIS", Silver/Ebony, Mirecourt c. 1950


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Maker's Mark Bourbon
Out of stock
Sale Price $39.99 Regular Price $42.99
More than 50 years ago, Kentucky distiller Bill Samuels, Sr., founder of Maker's Mark, set out to make a better tasting bourbon whisky. What he discovered was that if you used winter wheat in the mash instead of the traditional distiller's rye, your bourbon whisky was smoother and less bitter...and that's made all the difference. As distinct as the Maker's Mark® taste are its bottle and name. Designed by Margie Samuels (wife of Bill Samuels, Sr.), the square-shape container was inspired by her collection of cognac bottles. In keeping with the look of the French spirit, Mrs. Samuels decided to hand dip the very first bottles in red wax in her kitchen home fryer—a process that has now expanded and has blessed millions of the famous bourbon bottles. Taking it one step further, Mrs. Samuels, a collector of English pewter, recognized that any worthy craftsman uniquely branded each of his creations with what became a personal "Maker's Mark." She deemed it a perfect title for her husband's handmade bourbon. The iconic bottle and wax defines the care that goes into making each bottle of this hand-crafted bourbon. Since the first bottle sold in 1958, each bottle is still hand-dipped with a red wax by people, not machines. Rich, buttery nose with hints of raisins and honey; flavors include vanilla, honey, oranges, and a well balanced backdrop of leather and spice.
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Banjo #371 fretless Gourd 5 string "Modified Buckbee "
Mahogany neck
Oak fretless fingerboard 26 3/16″ scale
Modified Buckbee Minstrel peghead
Ebony friction tuners
Barry Sholder standard string set
Corian nut
Canteen gourd 10 1/2″ dia. x 4 1/2″ deep
2″ soundport
Goatskin head
* this banjo can be custom ordered with frets.
- Description
This is a new Barry Sholder Gourd 5 string fretless banjos with a Minstrel style Modified Buckbee peghead. I really like the simplicity of the instrument. Beautiful Mahogany neck and peghead. Oak fretless fingerboard all with a matte oil finish..silky smooth.


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Tad and Dianne Taube Senior Fellow
Peter Berkowitz is the Tad and Dianne Taube Senior Fellow at the Hoover Institution, Stanford University. Since 2019, he has been serving on the State Department's Policy Planning Staff in the office of the secretary. He is a 2017 winner of the ...
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Rep. Thaddeus McCotter explains the substantive differences between conservatives and the Obama administration relative to the stimulus...
Rahe Of Sunshine
Paul Rahe, a professor at Hillsdale College, believes the country is going to hell in a hand basket. . . .


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Discover one of the most famous cities in the world in a very special way. A tour around the wonders of Rome just for you and for those accompanying you.
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Tiberias, Israel, the largest town of Galilee, sits on the lakeshore. It's a vibrant modern resort that attracts tourists year-round. Tiberias is famous for its natural hot springs where you can soak in thermal pools just as others have done for centuries.
At the Hammat Tiberias National Park, south of the city center, the Ernest Lehman Museum contains the remains of a sixth-century Turkish bathhouse. Parts of a fourth-century synagogue are also visible, including its beautiful mosaic floor. In the city center stands the Archaeological Gardens, where excavations of the Byzantine and Crusader periods can be seen.
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Be sure to have a dinner of St. Peter's fish, fresh from the lake, at one of the restaurants along the waterfront promenade. Ferries arrive and depart from Tiberias, crossing the lake to Ein Gev.
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Your Travel Specialist
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You don't have any saved vehicles!
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Beyond the assurance of a painstaking certification process and 24-hour Roadside Assistance, every Certified Pre-Owned Mercedes-Benz now comes with industry-leading coverage: an unlimited-mileage warranty for one year that can be extended for up to two additional years. So no matter what your odometer reads, your confidence will know no bounds.
Had a fantastic car buying experience with Dalton Bowman! He is very knowledgeable & was a pleasure to work with from start to finish. He even responded immediately to questions after the sale. Ask for Dalton, he will go the extra mile to take care of you!
We had the pleasure of working with Marlon Velazquez on the purchase of our vehicle this past weekend. He is by far the best car salesman we have ever worked with. He helped us with finding the perfect car that fit our needs and budget and was never pushy. He has a fun, lighthearted personality and brings the joy back into buying a car. We highly recommend Marlon.
We purchased a used Lexus on 2/24/2020 our salesman Charles C., was very helpful in the purchase. He wasn't pushy, he answered our questions, was very courteous and we got to know some of his history. He has been there 38 years that tells you something about the company. Eddy the manager was also very good to work with as well as the finance person, Sorry can't remember your name. Very good buying experience.
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I have greatly enjoyed working with Marlon Velazquez for years. Working with him at Mercedes-Benz of Boise was no different. I truly appreciate all he does for me from being patient and always willing to have my back in the deal. I will continue to recommend him to anyone I talk to...even if his desk gets cold sometimes because they have to open the large doors to get cars out of and no wall barrier to block. All worth it to get to work with Marlon again and again.
Got the best car purchasing experience with Mark Seitz at lyle Pearson Mercedes Boise. He knows how to treat customers with due respect, patience & follow up after sales!
Mark Seitz did a wonderful job helping my husband and I pick out the perfect car! Amazing customer service, highly recommend!
Mark Seitz provided excellent service and was very knowledgeable. This is our first Mercedes but it will definitely not be our last. Mark has followed up with us to make sure we are getting all the benefits of owning a new Mercedes
Our Sales representative Mark Seitz was great! He handled our deal from start to finish! We are enjoying our used GL 320 and would definitely buy from him again.Thanks Mark!
Our salesman, Mark Seitz, was very welcoming and helpful. He answered all of our questions & if he wasn't sure of the answer he found out. The managers of both the service and parts department introduced themselves to us and we very generous with their time. Buying our new Mercedes was a wonderful experience.
Great Dealer ship and Mark Seitz was great to work with. Checks on your satisfaction with the sale and always says hello when visiting the Dealership. This isn't your average dealership everyone is great and great vehicles both new and used
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If we could give the Service Department a 10 star review, we would! On two different occasions Skyler and the service manager have completed an out of warranty repair, but very kindly covered the repair as the coverage was somewhat questionable. So nice they ruled in the customer's favor! Not living in Boise, we recently asked to drop by to show them an issue we had previously discussed by phone. To our surprise, Skyler had already ordered the part and was prepared to replace it the day we dropped by. They gave us a loaner car for errands and we ...
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When you're looking for a Mercedes-Benz dealer that serves Boise, Nampa, and Meridian, you expect it to have a vast inventory and a variety of useful services that'll make your car-buying experience even more exciting.
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(208) 377-3900Call Now
351 S Auto Drive • Boise, ID 83709Get Directions
Open Today! Sales: 9:30am-6pm
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Organic Green Tea with Ganoderma
Brief Introduce:
Chinese medical practitioners believe that taking reishi extract regularly can restore a person's health and promotes health and longevity as it helps the organs in the body to function normalyl Ganoderma lucidum (or called Reishi) two main ingredient is Ganoderma Lucidum(reishi) Polysaccharide and Triterpene.
Ganoderma Lucidum(reishi) Polysaccharide: Enhancing the immune system, suppressing and inhibiting growth and metastasis of a tumor, regulating blood pressure, preventing cardiovascular and cerebral-vascular diseases, activating insulin secretion, adjusting blood sugar; as well as producing anti-oxidation and anti-aging effects, among others.
Triterpene Ganoderma Lucidum(reishi) Acid: Showing effects in degrading alcohol, protecting the liver, killing cancer cells, relieving pain, alleviating inflammation, improving irritability, reducing cholesterol, preventing vascular stiffening, strengthening liver and digestive functions
Ganoherb Ganoderma Plantation
Ganoderma specialists find out that the virgin forest area in Mt.Wuyi is the most ideal place for growing Ganoderma lucidum. With the most appropriate climatic and geographic conditions for growing Ganoderma lucidum and free from pollution,this area is an ideal place for Ganoderma cultivation.
The first ganoderma plantation in China to receive organic certifications from China, the USA, Japan and the EU
Quick details:
●Product Type: Green Tea
●Type: Ganoderma lucidum green tea
●Age: 1 - 2 Years
●Style: Bagged Tea
●Packaging: Can (Tinned)
●Specialty: Health Tea, Organic Tea, Slimming Tea
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●Grade: AAAAA
●Shelf Life: 2 Years, 2 years
●Weight (kg): 0.0015
●Place of Origin: Fujian, China (Mainland)
●Brand Name: Xianzhilou
●Model Number: bag ganoderma green tea
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●Ingredients: Ganoderma lucidum and green tea
●Function: Anti-aging
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GanoHerb organic green tea with Ganoderma is refined from the optimum proportionning of natural organic ganoderma lucidum and organic green tea. It is rich in active ingredients, including ganoderma polysaccharides, ganoderma triterpenes, organic germanium and tea polyphenols, ect. The slight bitter flavor of ganoderma and the mellowness of green tea contribute to its refreshing sweet aftertaste. It is suitable for the white-collar in the office to drink regularly.
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Are you looking for how to start beekeeping in Bridgeport Pennsylvania? A lot of people say honey bee farming classes in PA can be expensive and there are alternative ways to master honey bee farming without spending a fortune in training.
Beekeeping is a business that depends on having passion that is complete. You can't if you do not like coping with live creatures begin a business such as this. Working with bees is like working with any other type of animals or birds; it wants care and knowledge to keep bees healthy and productive. You should take complete care of each matter that is little, to ensure that it does not create any problem for the company later on.
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NIKE Court Print Shirt
Additional Information
Product Detail
Style: 1049635NikeCourt Dri-FIT
Women's Tennis Top
Soft and lightweight, the NikeCourt Dri-FIT Top will power you through your toughest matches. A stylized bee print adds a touch of royalty to your look.
Dri-FIT technology helps you stay dry and comfortable.
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Back zipper provides easy on and off and locks to keep it in place as you move.
Throughout history, the bee has been used as a symbol of royalty and power. This repeating bee print honors that narrative and explores the hypothesis that the French Fleur-de-Lis is actually a stylized bee, rather than a lily.
More Details
- Fold-over collar
- Fabric: 100% polyester
- Machine wash
- Imported
|Delivery On
|Standard Delivery
|3-5 Days UK mainland delivery Mon-Sat if ordered before 5pm on a Friday (Exc Sundays)
|£4 (free over £60)
|UK Mainland only
|Next Day
|Currently unavailable
|UK Mainland only
|Northern Ireland Delivery
|2 day Mon-Fri when ordered before 5pm
|£7 (free over £80)
|Northern Ireland
|Remote Area
|2 day Mon-Fri when ordered before 5pm
|£10 (free over £100)
|UK Remote (Highlands and Islands)
By placing an order for home delivery with us you automatically agree to the terms and conditions of our delivery partners.
Please Note: We do not deliver to the Channel Islands.
Please be aware all personalized orders can take up to an extra 3 working days to be completed before they are dispatched. Once they are dispatched, they will be sent using the delivery service you have requested. Please see the grid below for delivery times.
Free Returns
We hope you are happy with your DW purchase, but if for any reason you are not, please see our returns options below.
For further information, please see our delivery & returns page
|Time to refund
|Refund and Exchange policy
|Collect+ (Return)
|Up to 10 working days for funds to show in your account
|Up to 90 working days for home delivery with orders placed from the 23rd of March.


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Football Kenya Federation will on this Wednesday decide on the fate of the Betway Shield Cup matches which did not take off last weekend.Notable round of 16 matches which were not played are;Gor Mahia vs Posta Rangers,KCB vs Wazito and Bandari vs Sofapaka. The duo of Gor Mahia and KCB did
Latest News
Sharks,Ulinzi and Leopards advance to Shield Cup quaters
The Kenyan Premier League trio of AFC Leopards,Ulinzi Stars and Kariobangi Sharks have booked places in the Betway Shield Cup quarter finals after winning their round of 16 matches. Sharks saw off FC Talanta 4-1 at Camp Toyoyo where their goals were scored by John Otieno who registered a brace.Geoffrey Lemu
City Stars put off Stima by a solitary goal to edge closer to KPL return
Nairobi City Stars edged closer to returning to the Kenyan Premier League after putting off Nairobi Stima 1-0 at Camp Toyoyo. The National Super League leaders had Ebrima Sanneh to thank as his sole goal was enough to secure them maximum points in a match played behind closed doors. Elsewhere,Administration Police's plummeted
Federations postpone local competition
After the first case of the coronavirus was reported in the country,sports federations were left with no choice other than to shelve their activities indefinitely Below are some of the statements from various federations; "Following the Ministry of Health confirmation of a Coronavirus disease (COVID-19) case in Nairobi, the National Olympic Committee
Fkf suspends competitions,spares this weekend's Shield and NSL matches
Football Kenya Federation suspended all the competitions in the country following the first case of the Coronavirus in the country reported on Friday.Fkf called off all KPL,grass-root and Women football competitions as part of the precaution measure to the growing fear of the deadly virus However,the federation spared this weekend's Shield
Mediterranean Cup shelved
The Mediterranean International Cup's direction committee has canceled this year's event, in which the Kenya U16 national team was set to take part in starting Tuesday, April 7, in Girona, Spain. This was occasioned by the "unquestionable seriousness" of the COVID-19 pandemic which led to the Catalonia General Secretary of Sports
Otieno resumes training after months on the sidelines
Gor Mahia and Harambee Stars right back Philemon Otieno has resumed training four months after going under the knife Otieno has been out since August last year's when he suffered a knee injury while in action against Tanzania in a Chan qualifier match The former Ushuru midfielder's career was nearly punctured by
Gor players down tools
Maloba returns after weeks of absconding duty
Nairobi City Stars creative midfielder Oliver Maloba has returned to the squad after weeks of absconding duty.Maloba, whose trail had gone cold on the club since the second week of February, met the club honchos on Monday and after lengthy discussions was allowed back in training starting on Tuesday. Speaking on
Ouma elated with Turkish Cup performance
Harambee Starlets head coach David Ouma lauded his team for their performance at the just concluded Turkish Women's Cup where they came third behind Chile and Ghana. Starlets beat Northern Ireland 2-0 in their opening match before falling to Chile (5-0) and Ghana (3-1), with the coach noting that there are


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Would you believe it, there are now wolves in The Netherlands. Apparently they sneaked over the border from Germany near Maastricht when no one was looking. Wolf enthusiasts suggest that the Land of Windmills can sustain twenty two wolf packs. That sounds a lot to me, given how much of The Netherlands is polder. Surely wolves and polders don't mix? Anyway, please don't tell Nigel Farage. It won't be good for his health - just another reason to fear the perfidious foreigner with his primitive ways and pernicious pets.
Down in Rockingham Forest, the authorities did their bit for the highly successful reintroduction of the red kite, a bird about which almost no one has a bad word to say, although once I did see a RK go for a chicken in a Wadenhoe garden, and the chicken didn't think too much of it. The conservationists are trying to get an adder population going in Fineshade, which won't delight everyone, especially the chap whose dog was allegedly bitten in Northampton's distinctly urban Lings Wood, although this was an event which has caused considerable puzzlement ever since because of its rarity. Then again, adders aren't the biggest animals. It would be easy to miss a small survivor population, and I once saw what I think was a shed adder skin near Whiston. I'm not so sure about repopulating Scotland with lynx, but there was an encouraging telly report a few months ago about the recovery of pine martens, and another showing ways to support red squirrels. At a more mundane level there's work to be done keeping favourite British species like the hedgehog and the kingfisher alive and snuffling/fishing. The latest conservation project in Rockingham forest is the Chequered Skipper butterfly, celebrated in the name of the once excellent Ashton (nr. Oundle) pub. It seems that's now defunct too, more's the pity. At this rate we'll have to start conserving pubs as well, perhaps as community projects.
Does our love of diversity in the natural world, and our understanding of eco-balance and the sustainability of populations have any light to shine into how we conduct Church life?
On the subject of diversity (picking up from the previous post) the case of the Samoan Australian rugby star Israel Folau has been much on my mind this week, and perhaps yours too. He tweeted that hell awaited drunks, homosexuals, adulterers, fornicators, liars, thieves, atheists and idolators, and for his pains has had his contract with Rugby Australia terminated. The coach Michael Cheika, not exactly a verbal shrinking violet himself, said at a press conference, 'Getting out in that disrespectful manner publicly is not what our team's about. When you play in the gold jersey, we represent everyone in Australia – everyone. We don't pick and choose…' No sinners in Australia, then. I thought so. English cricket fans have always known this.
Is Folau entitled to his view, right or wrong? Of course! Is he entitled to express it on social media i.e. does this cross into 'hate speech'? Opinions will differ. Personally, I don't think there's necessarily a problem, any more than there's necessarily a difficulty with the quasi-technical expression 'Zionist', though that's proscribed now if you're a Labour Party member. Is he entitled to express it in his capacity as a representative of Rugby Australia? That depends on what it says in his contract. Can most of the public see the boundaries and intermeshing of these issues? Quite possibly not. There was a telling comment by a not-unfriendly commentator on Radio 5 the other evening who said that once upon a time ( 30 years ago?) someone from the mainstream might say defensively 'Some of my best friends are gay…' Now they might say, 'Some of my best friends are Christians…'
How do you social pariah Christians feel about that? (regardless of whether you agree with Folau). I know I'm repeating myself, but the theme of this blog is that we're better together as Christians (and society), Evangelicals, Catholics, Fundamentalists, Radicals, Seekers, The Lot. Let a thousand flowers bloom. Judge not, lest ye be judged, Michael Cheika! The subsequent problem, so well instantiated in the Brexit deadlock, is that we can't remain paralysed, we still have to act.
I study the site map in the Fermyn Woods car park trying to make up my mind whether to stride out or wait ten minutes for the café to open. At my shoulder a ten year old girlwoman hovers, throwing some balletic shapes for the benefit of her unimpressed, distracted mum. 'This is a 'rond de jambe', and that's a 'pas de chat'', she says. 'In a foreign language, then…why's that?' Mum asks. 'They're like, dance moves, innit,' replies the daughter.
I give up on empty-calorie coffee and cake and hit the Lyveden Way for a few hundred metres before branching out across the fields in the direction of Sudborough. Most of today's walk will be either in woodland or open rolling countryside, but the approach to Sudborough is by the verge of the busy A6116 Corby road. I was an early teenage trainspotter, and picking my way along the narrow strip of grass brings back memories of standing on the draughty platform at Hither Green as the diesel-powered Hastings express hurtled past towards Charing Cross. A forty tonner creates a deal of turbulence in its wake. Verge walking is the most annoying thing. The grass is usually thick, concealing all manner of hidden dangers from broken glass to rabbit holes: 'And all is seared with trade; bleared, smeared with toil…' Hub caps, discarded 'L' plates, plastic food cartons…
Sudborough's very nice though, handsome cottages and pleasant gardens. All Saints church is open for a bit of psalm reading (please don't miss out the 's' in that last word!) I muse on the appearance of sheep in Psalms 78,79 and 80, and think how wonderful that Palestine and Northamptonshire are linked by my favourite farm animal. I sometimes worry that instead of the happy, loving, sorrowful relationship between God and his sheep, today's clergy see only the alleged silly aspects of the animal. Do they view the laity as perpetually going astray or blindly following each other with themselves cast as the put-upon shepherd(esse)s? Is that a fair cop, Reverend Persons?
Inside the church, I'm unexpectedly moved by the tiny brass set into the wall dating from 1390 commemorating the West family: William, Joan his wife, and a quiver full of children. Last Sunday we celebrated forty Aprils to the day since we took a party of thirty young dancers and musicians to the East Coast of the US, performing in the foyer of the ill-fated Twin Towers among other venues. That event has the quality, increasingly familiar with the passing years of seeming at the same time like yesterday and an aeon ago. The Sudborough brass is 630 years old, but the intimacy and love of the West family stretch out towards the viewer, and time collapses as one makes friends with them through their graceful, touching memorial.
Out of Sudborough I cross the road on a dangerous bend (nb!) and very soon find myself on a wondrous, greening, woodland path fringed with primroses and a few first, uncertain bluebells. It climbs slowly to the top of the rise, culminating in the broadest of views over the Nene valley, the hedges covered in snowy May blossom, the woods to either side shimmering a little in the mid-day sun. I can see one of Aldwincle's churches and think I'm heading there to pick up the Nene Way, but get confused and end up on my Plan B route which after a green lane takes me across the flat through a friendly, sheepy field to a favourite Northamptonshire spot by Wadenhoe's St. Michael and All Angels church with its comforting, monasterial, saddleback tower (which is a survivor from an earlier phase of building).
Next to it are the mounds of a once substantial castle. Looking east over the river from the Millennium Sundial, one can see three other churches. It's Wadenhoe that provoked my earlier solemn melody for the vanishing village pub. The King's Head here has been a regular haunt for a decade. You'd think it had it all: a pluperfect, picturesque village with river moorings, not so far from the A14 and half an hour's drive from Peterborough, a nice garden, friendly staff, locally-sourced produce…but now the King's Head too has shut its doors. Let's hope for a revival (which is something I'd normally say in a church connection. Perhaps the two kinds of revival go together.)
From the village I pick up the Lyveden Way along a track past an attractive farm at Wadenhoe Lodge. As often at this time on a walk, I stop noticing and start turning over the refuse in my mind's dustbin. At the moment I'm reading AJP Taylor's Origins of the Second World War, a book which excited a great deal of debate when it was published in the early nineteen sixties, including a spat of almost Snow/Leavis proportions between Taylor and Hugh Trevor Roper, another leading historian of the day. Taylor's overall thesis was that Hitler wasn't a madman, but a mainstream German politician pursuing traditional German foreign policy aims, and that what we call the Second World War (in reality a conjunction of at least two, perhaps three, separate conflicts), was largely the result of miscalculations on all sides. Most other people disagreed then, as I think they would even more today. I'm trying to understand the current European dilemmas by looking back, to see what resonances there might be in the past, and what's different now. One uncomfortable theme is that not only was the pre-New Deal US isolationist in the very early nineteen thirties, but Britain was too, or so Taylor claims (though it was still administering the end of Empire) – and surely those world views mirror current popular sentiment? Clearly Taylor (in 1960 and against the background of the Soviet bloc!) saw Poland as a non-viable political entity, which with some crossing of fingers, seems an outlandish thought now. I'd forgotten that Gdansk, then Danzig, which seemed so irreducibly Polish when we visited fifteen years ago, was once seen as a sine qua non German enclave to the point of being a casus belli in '38/39. The idea that the Italians might think Nice was really theirs, rather than French, came as a shock to me. And what do we make now of a mutual defence pact – which came to nothing – between France and Czecho-slovakia, with or without its hyphen? Can we as 'Britons' ever get over our history as an 'island race'? Like many others, until ten years ago I thought that a thing of the distant past, but am now far more pessimistic. Taylor's book is uncomfortable reading.
Down and up, and through Lilford Wood, into the grounds of Lyveden New Bield. If you've not been, it's a very strange place, a perfectly unfinished seventeenth century house standing on the middle of a wide plain, in its own weird way as evocative a setting as Stonehenge. We're in Thomas Tresham territory again, he of Rushton Hall and the Triangular Lodge, so all over the shop there's mystical symbolism with a Catholic slant. On a bright day like today, you half expect a bunch of builders to turn up and begin finishing the job with merry quips and whistles. On a dark winter's afternoon with the wind blowing, we're talking Cathy and Heathcliff. I can't come away from Lyveden at any time of year without a certain emptiness of spirit and sense of foreboding, hopes unfulfilled, plans thwarted, vision overwhelmed.
Have I got this right?
I find The Truth to be a slippery thing.
I'm no post-modernist.
For instance,
I'm not going to go along with Baudrillard
And say the first Gulf War never happened.
But aren't there enough grounds for humility
In what we don't know about the universe,
In understanding that I comprehend the world around me
Only through unreliable sense-data,
In repeatedly being shocked by my foolish misapprehensions
And in confronting the certainties of others?
So how do I 'preach the Gospel'?
And what do I do about the feeling
That my 'truthful' uncertainty
Has never won anybody for
The Kingdom of Heaven?
Sanctify and bless my doubts.
Give me the simple faith
'like those who heard beside the Syrian Sea'
To rise up and follow Thee.


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BLITZKID - Escape the Grave Tour w/ Ghost Road, Defiant Brood, Children of October
Sat. May 9, 2020 at 8:00pm EDT
18 and Over
29 days away
$15.00 - $50.00
18 and Over
- Get Tickets
- Details
- Comments
Event Stats
29 days away
$15.00 - $50.00
18 and Over
Event Description
Blitzkid "Escape the Grave Tour" Saturda May 9th 8pm. Support by Ghost Road. $15adv/$20dos 18&up
VIP eet & Greet Available for $50
Blitzkid RIP VIP includes:
* Early Venue Entry
* Advance Merch Table Access
* Exclusive Tour Poster
* Merch Signing
* M&G w/ Photo Opportunity
* Intimate Acoustic Performance
After eight years of suspended animation, BLITZKID are poised to pry back the casket lid and escape the grave for a limited run of spring 2020 tour dates. The ghoulish troupe are primed to play a string of exclusive performances across the US before slipping back into their shadowy sleep. General Admission tickets along with limited meet and greet options (which include early entry, exclusive merchandise and a pre show acoustic performance) will be available JANUARY 17th via all ticket links provided at www.acwnnprod.com/shows
Join the Conversation
- Twitter: @123pleasant
- Instagram: @123pleasant
Follow the event with #123pleasant


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Date Posted: January 16, 2020
Job Location: Boyle
Job Number: GWF-80123
Job Type: Full Time
Start: February 14, 2020
Company: Alberta-Pacific Forest Industries Inc.
Website: alpac.ca
Address: Box 8000, Boyle, Alberta, Canada T0A 0M0
Alberta-Pacific Forest Industries Inc. (Al-Pac) is seeking a highly motivated, enthusiastic and supportive team player for the role of Buyer.
This is a long-term permanent position working Monday-Friday at our mill site. The successful candidate will receive a competitive annual salary including paid pension and matching RRSP program, 4-week's annual vacation, company paid dental and extended health benefits, with many additional employee incentives.
• Collaboratively develop and issue RFQ, RFP, RFI, Purchase Order and Contract documents; lead processes to source variety of goods and services in accordance with Al-Pac policy, standards and procedures.
• Develop commercially competitive contracting and procurement strategies for assigned portfolio in collaboration with the business areas, with the aim of achieving consolidation of requirements and contracts across the organization to optimize value and reduce risk.
• Negotiate and award agreements to contractors and/or suppliers to ensure services and materials are provided in the most cost effective and proficient manner possible.
• Identify and recommend opportunities to Business Units that will reduce Al-Pac's total cost of ownership and/or increase Al-Pac's profitability and efficiency, including, drawing on your knowledge, consideration for industry best practices.
• Recommend and implement appropriate procurement strategies through a broad knowledge and detailed analysis of market conditions, Al-Pac's business requirements, risk and assessment of opportunities.
• Manage supplier relationships effectively and, collaboratively drive continuous performance improvement via relevant contract key metrics.
• Conduct spend and market analysis and benchmarking studies as required. Present findings and conclusions/recommendations to Leadership and Business Units.
• Exhibit a professional and ethical responsibility to protect privacy, use information appropriately, and maintain the confidentiality and security of all information.
• Participate in the "On Call" rotation of the Business Unit.
• Adherences to all corporate policies, procedures and Supply Chain Canada code of ethics.
• Perform other duties and special projects as assigned.
• 7+ years of related procurement experience within an industrial setting, combined with a university degree or related post-secondary education.
• Demonstrated time management, results orientated, excellent organizational skills, strong problem solving and analytical competency and decision making ability.
• Demonstrated experience with RFQ/RFP evaluations, negotiating contract and commercial terms, contract execution and administration/management.
• Well-developed communication and interpersonal skills, with the ability to work independently and collaboratively in a team environment; strong team player.
• Experience with assessing and managing commercial risk, liability and legal terms and conditions.
• Experience mentoring team members.
• Experience with Engineering and Construction would be considered an asset.
• Demonstrated professional development.
• A commitment to quality and customer service.
• Proficient in MS Office Suite as well as competence and confidence with other software.
Please forward your resume in confidence to email@example.com.
We wish to express our thanks to all applicants for their interest and effort in applying for the position; however, only candidates selected for an interview will be contacted.
Alberta-Pacific Forest Industries Inc. is an equal opportunity employer and encourages applications from all qualified individuals.
The closing date for this position is January 26, 2020.


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Maristi cushion cover
Downloadable pattern
Downloadable pattern
Cushion cover designed to use up small quantities of Shetland yarn.
Ordering information for both Jamieson & Smith and for Jamieson's of Shetland is included.
Two circles are knitted then joined to make a round cushion cover which can be filled with a cushion pad, clean wool or trimmings from other Fair Isle projects.
Tension is not crucial.
Last 2 photos also show how using different colours completely changes the appearance


text: The first thing that one must have in mind regarding the Everest Base camp trekking is that it is in reality not as scary as it is often considered to be. Rather, it can be full of thrill and fun, if someone addresses some basic aspects. Discussed below are a few handy tips in this regard.


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More than 70 percent of the one hundred largest cryptocurrency exchanges on Coinmarketcap significantly overstate the volume of trading and engaging in money laundering. This is stated in the study Blockchain Transparency Institute (BTI), which leads Bitcoin.com.
Analysts BTI analyzed data for 130 cryptocurrency exchanges — found that together they overstate the trading volume at $ 6 billion. The worst situation in five exchanges of the top 10 — BCEX (12th, trading volume is overstated in the 22 thousands of times), LBank (11, 4.4 thousand times), Bit-Z (9, 469 times), ZB (6th place 391 times) and Bibox (8th place, 85 times).
What's the exchange inflate trading volume
For example, the exchange Lbank and ZB, which are among the top ten stock exchanges in Coinmarketcup, they claim to have the volume of trading in the area of 214 000 and 74 000 dollars per user per day, respectively. It's strange given the fact that the well-known highly liquid trading platform Bitfinex, Coinbase have Binance and from 5000 to 8500 dollars for one visitor a day.
In my own rating of BTI took first place Binance, followed by Bitfinex, Coinbase, and Kraken Bithumb. The above exchange, which researchers are accused of inflating trading volume, was not included even in the top 100.
While the exchange has not commented on the study, and Coinmarketcup did not update its rating in accordance with the results BIT.
In March, researchers cryptocurrency startup Dashlan estimatedthat systems identify users, 70 percent of the 35 largest cryptocurrency exchanges have bugs that expose them to financial risks.
What do you think about the current situation? Share your opinions in cryptodata.
Don't want to be deceived? Subscribe to our channel in the Telegram, arm yourself with knowledge.


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Wisconsin Farmers and Food Producers at the Market
Aleka's Kitchen
Savory and sweet Greek specialties, marinated Greek olives, feta cheese, savory dips, olive oil
Email: firstname.lastname@example.com
Chalkboard Kitchen
Homemade granola. scones, cookies and party mix. Full menu catering.
Phone Number: (262) 389-9991
Egg Rolls and More
Traditional egg rolls , spring rolls, and pork dumplings
Elsie Mae's Canning and Pies
Pies, jams, drink concentrates
Email: firstname.lastname@example.com
Fine Fettle Farm
Organic produce
Email: firstname.lastname@example.com
Happy Destiny Farm
Organic fruit, pie Filling, jams, salsa, free-range chickens and eggs
Jeff-Leen Farm
Hormone- and antibiootic-free pastured Piedmontese beef, chicken, chicken brats and breakfast sausage, cage-free eggs, beef sticks and summer sausage
Email: firstname.lastname@example.com
Khoua Lee Farm
Fresh produce
Log Cabin Orchard
Apples (late summer), syrups, jams, cider vinegar, apple hand pies
Phone: (920) 893-6073
Lopez Bakery
Tamales, Mexican bakery (churros, cookies), breakfast burritos, Mexican soda, guacamole, salsa and chips
Phone: (414) 672-1830
Madame Macaron MKE
Maxx's Munchery
Oven baked pet treats
Wholesome Dog Treats, Dog Birthday Cakes
Moss Doli
African + French = Senegalese Cuisine
Beignets. fatayas, chicken stew, citrus punch
Muse Brews
Email: firstname.lastname@example.com
River of Dreams
Free-range cickens,eggs, pastured beef, lamb and pork
Phone: (920) 756-2725
River Valley Ranch
Fresh, dried and pickled mushrooms, pasta sauces
Rocky's Flowers
Rolling Meadows Honey Farm
Local honey and kettle corn
Phone: (414) 530-1449
Sharp Brothers
Knives, scissors and gardening tools professionally sharpened while you shop.
Soap of the Earth
All natural soaps made without dyes or chemicals. Pamper your skin with bar soaps, liquid hand soap for the kitchen and shower gel.
Stamper Cheese
Wisconsin cheese
TK Produce
Fresh produce
Wallah Mango Lassi
Mango lassi and mango juice, sorbet and ice cream
Wild Flour Bakery
Bakery without preservatives or artificial ingredients including muffins, cookies and breads
Wisconsin Soup Company
Hand-crafted small-batch soups made with locally sourced ingredients . Samples!


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