text:
I have looked through many Paleo cookbooks and this one has become my favorite! Many paleo cook book recipes use a lot of expensive ingredients and are time consuming. This book os not like that. I have tried many of the recipes and they are delicious! Sometimes I do not have much time to spend in the kitchen and this book provides recipes for those who live very busy lives. I highly recommend this book!
Why eat crap food when you don't have to? Better yet, why eat healthy food that doesn't taste good? There's no need to do that eve...r again with Juli Bauer's Paleo Cookbook. New York Times bestselling author of The Paleo Kitchen and creator of the popular website PaleOMG, Juli is a well-known Paleo cook who creates meals that are sure to please the whole family. And this cookbook is her best one yet! Absolutely no one will complain when you serve them delicious dishes like Breakfast Tacos, Buffalo Chicken Casserole, Slow Cooker Short Rib Tostadas, Pistachio Rosemary Lamb Chops, and Layered Flourless Chocolate Cake. For most people, the Paleo or "caveman" diet seems unrealistic. "You expect me not to eat cake anymore?" was Juli's first reaction. (There may have been a few curse words thrown in there, too.) For Juli, that just wasn't going to work. We all understand that cavemen didn't eat cake back in the day, but we're here in the future, and we can create Paleo-friendly cakes. So Juli ventured out to put a new spin on eating like a caveman. After two weeks of eating Paleo, she knew she was in it for the long haul. She has been eating Paleo for five years now, and she consistently gives her readers Paleo recipes that bring back childhood meal memories or just bring back the foods they love the most. There's no need to be a true, pretentious caveman if you don't have to be! We see you using Instagram over there, you modern caveman, you. Paleo is about so much more than just food. To Juli, Paleo is what gave her the freedom to feel healthy, energetic, and enthusiastic about life. And that's exactly what she is trying to bring to you in this cookbook. She hopes not only to help you revamp your kitchen and excite your taste buds, but also to help you feel confident with the new lifestyle you've taken on. read more
Slow cookers are amazing tools for any person and any kitchen. I love the fact that you can put it in and go back hours later without having to do much of anything in between! The great thing about this cookbook is that it's simple and gets straight to the point. With only 40 recipes in the book, you won't get overwhelmed by an overload of possibilities and ideas. Instead, you can focus on what really matters: the food!
Spiced Hot Apple Cider Mint And Citrus Water Matcha Smoothie Paleo Eggnog Pink Grapefruit Lemonade Peach And Raspberry Lemonade Strawberry-Kiwi Mojito Smoothie Chocolate Avocado Strawberry Smoothie Frozen Coconut Strawberry Drink Pomegranate Green Tea Coconut Milk Hot Chocolate Frozen Chocolate Smoothie Watermelon Sports Drink Frozen Coconut Limeade Coconut Strawberry Lemonade Lemon Mint Iced Tea Raspberry-Lime Flavored Water Fresh lemonade with thyme Strawberry rhubarb lemonade Banana Mango Smoothie
This recipe gives you dinner party elegance in a 20-minute dish. We rely on sea bass, a tender, mild-flavored fish with a lovely buttery quality. There are several sustainable options to choose from (Atlantic black sea bass, for one), so ask questions at the fish counter to ensure you're making a responsible choice. You can also use cod, sablefish (also called black cod), striped bass, or barramundi with great results.
These recipes are created with ease in mind, as we're often cooking for others and accommodating our busy schedules… but they also all taste amazing. These are the same recipes we take to barbecues and birthday parties to be enjoyed by several people with different tastes. You can be sure that you will enjoy cooking these recipes as much as you'll enjoy eating them – and food is always better when shared!
If you love the taste of curry but don't know how to make it, this soup can serve as a reliable way to get that flavor without having to memorize a difficult recipe or use curry from a jar. There are plenty of ingredients being used here, but you'll see in the directions that it's just a matter of combining them all together, so it's not complicated. You end up with an amazing curry soup that has interesting things like almonds in it to give it a crunch you don't usually get with curry. They're also giving it healthy fat and additional protein which is very helpful.
I don't know about you, but I rely on blogs and cookbooks for advice when I'm trying to cook healthier—in fact, this recipe a friend sent me for a Paleo breakfast casserole basically got me through my Whole 30 (I never even got sick of it). Having meal inspo at the ready is key to sticking to your goals, and we just so happen to have found the best Paleo cookbooks out there. In case you aren't familiar with the Paleo diet, people associate it with eating like a caveman—you basically consume a lot of protein, fresh veggies, and good fat while saying goodbye to processed foods and most sugars.
Even though these have been dubbed "finger lickin'" Colonel Sanders has nothing to do with these. That's because they're not made with chicken, but with beef. They pack a bit of a kick because of the chipotles used, but not so much that it overpowers the other ingredients. There are plenty of Paleo ingredients used, both in the meatballs, and in the sauce. You'll find tasty items like coriander seed, garlic, paprika, and bay leaves. You'll find that the Paleo diet is not very restrictive, it's just a matter of finding the right mix of spices and seasonings to make the food taste as good as it can.
The benefits of a grain-free diet has been proven through the personal experience of hundreds of people worldwide who have experie...nced significant relief from a wide variety of auto-immune diseases. The rise of the paleo movement has introduced grain free eating to the masses, and is embraced by many as a healthy way of eating for anyone. read more
Feeling full and fulfilled when you're on a diet may seem impossible, but it's the only way to turn your diet into a healthy lifestyle. Naturally promoting superior health and weight control, The Paleo Cookbook serves up wholesome recipes from around the world that emphasize lean proteins, vegetables, fruits and healthy fats. A staple for any paleo table, The Paleo Cookbook gives you your fill of a healthy and balanced life with every dish.


text:
okay cool. I will.
okay cool. I will.
<br>Originally Posted by Fervid
i need 7 more ppl PM me if u wanna join
IGN: Tedx
Only team I would like to see play on client are:
Arcanum and AsianKillers.
We are still looking to get some more teams signed up keep in mind this is the first of many to come as well as different formats.
Signups extended for a week. Cmon teams sign up for this amazing event.
Anybody in need of a member? i'm looking for a team to join, i do english and spanish flawlessly.
IGN: Pez
I'm not that much of a pro but i think i play decent enough and really look forward to participate, Cheers!
-La Maldad nace de la supresión hipocrita del odio.-
sorry arcanums XD
I dont see this as cheating, but does using autohotkey to change my mouse sensitivity on the go and limit my clicking rate count? cause i'd like to join a tourney league for this game, but would be pointless if i cant use my tourney set up.

subset: commoncrawl


text:
No products in the basket.
All deliveries sent by Royal Mail. Last posting for Christmas: Wed 18th Dec for 2nd class, Fri 20th Dec for 1st class.
Lost your password? Please enter your username or email address. You will receive a link to create a new password via email.
Username or email
Reset password


text:
Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling Sci. Transl. Med. (IF 17.161) Pub Date : 2020-04-01 Jesse D. Kirkpatrick, Andrew D. Warren, Ava P. Soleimany, Peter M. K. Westcott, Justin C. Voog, Carmen Martin-Alonso, Heather E. Fleming, Tuomas Tammela, Tyler Jacks, Sangeeta N. Bhatia
Lung cancer is the leading cause of cancer-related death, and patients most commonly present with incurable advanced-stage disease. U.S. national guidelines recommend screening for high-risk patients with low-dose computed tomography, but this approach has limitations including high false-positive rates. Activity-based nanosensors can detect dysregulated proteases in vivo and release a reporter to
PBX1 expression in uterine natural killer cells drives fetal growth Sci. Transl. Med. (IF 17.161) Pub Date : 2020-04-01 Yonggang Zhou, Binqing Fu, Xiuxiu Xu, Jinghe Zhang, Xianhong Tong, Yanshi Wang, Zhongjun Dong, Xiaoren Zhang, Nan Shen, Yiwen Zhai, Xiangdong Kong, Rui Sun, Zhigang Tian, Haiming Wei
Abundant decidual natural killer (dNK) cells at the maternal-fetal interface are important during early pregnancy. However, functional subsets of dNK cells remain poorly understood. We describe a CD49a+PBX homeobox 1 (PBX1)+ dNK cell subset that promotes fetal development in humans and mice. The expression of PBX1 in dNK cells is up-regulated via the activated AKT1 pathway through the interaction of
Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer Sci. Transl. Med. (IF 17.161) Pub Date : 2020-04-01 Sumit K. Subudhi, Luis Vence, Hao Zhao, Jorge Blando, Shalini S. Yadav, Qing Xiong, Alexandre Reuben, Ana Aparicio, Paul G. Corn, Brian F. Chapin, Louis L. Pisters, Patricia Troncoso, Rebecca Slack Tidwell, Peter Thall, Chang-Jiun Wu, Jianhua Zhang, Christopher L. Logothetis, Andrew Futreal, James P. Allison, Padmanee Sharma
Tumors with high mutational burden (TMB) tend to be responsive to immune checkpoint blockade (ICB) because there are neoantigens available for targeting by reinvigorated T cells, whereas those with low TMB demonstrate limited clinical responses. To determine whether antigen-specific T cell responses can be elicited after treatment with ICB in cancers that have a low TMB, we conducted a clinical trial
The neural circuit model in psychiatry pays off Sci. Transl. Med. (IF 17.161) Pub Date : 2020-04-01 Jennifer Strafford Stevens
Noninvasive brain stimulation in depressed patients can be used to target different neural circuits, improving different symptoms.
Macrophages make you stronger Sci. Transl. Med. (IF 17.161) Pub Date : 2020-04-01 Jan Van den Bossche
Macrophage-derived meteorin-like promotes skeletal muscle repair.
Spontaneous reversal of stenosis in tissue-engineered vascular grafts Sci. Transl. Med. (IF 17.161) Pub Date : 2020-04-01 Joseph D. Drews, Victoria K. Pepper, Cameron A. Best, Jason M. Szafron, John P. Cheatham, Andrew R. Yates, Kan N. Hor, Jacob C. Zbinden, Yu-Chun Chang, Gabriel J. M. Mirhaidari, Abhay B. Ramachandra, Shinka Miyamoto, Kevin M. Blum, Ekene A. Onwuka, Jason Zakko, John Kelly, Sharon L. Cheatham, Nakesha King, James W. Reinhardt, Tadahisa Sugiura, Hideki Miyachi, Yuichi Matsuzaki, Julie Breuer, Eric D
We developed a tissue-engineered vascular graft (TEVG) for use in children and present results of a U.S. Food and Drug Administration (FDA)–approved clinical trial evaluating this graft in patients with single-ventricle cardiac anomalies. The TEVG was used as a Fontan conduit to connect the inferior vena cava and pulmonary artery, but a high incidence of graft narrowing manifested within the first
A durable protective immune response to wild-type measles virus infection of macaques is due to viral replication and spread in lymphoid tissues Sci. Transl. Med. (IF 17.161) Pub Date : 2020-04-01 Wen-Hsuan W. Lin, Eileen Moran, Robert J. Adams, Robert E. Sievers, Debra Hauer, Steven Godin, Diane E. Griffin
Infection with wild-type (WT) measles virus (MeV) is an important cause of childhood mortality that leads to lifelong protective immunity in survivors. WT MeV and the live-attenuated MeV used in the measles vaccine (LAMV) are antigenically similar, but the determinants of attenuation are unknown, and protective immunity induced by LAMV is less robust than that induced by WT MeV. To identify factors
Location, location, location: A tubal neighborhood unfriendly to implantation Sci. Transl. Med. (IF 17.161) Pub Date : 2020-04-01 Ramakrishna Kommagani
Reduced adrenomedullin secretion by tubal epithelial cells results in increased macrophage function and increased susceptibility to ectopic pregnancy.
Control of brain tumor growth by reactivating myeloid cells with niacin Sci. Transl. Med. (IF 17.161) Pub Date : 2020-04-01 Susobhan Sarkar, Runze Yang, Reza Mirzaei, Khalil Rawji, Candice Poon, Manoj K. Mishra, Franz J. Zemp, Pinaki Bose, John Kelly, Jeff F. Dunn, V. Wee Yong
Glioblastomas are generally incurable partly because monocytes, macrophages, and microglia in afflicted patients do not function in an antitumor capacity. Medications that reactivate these macrophages/microglia, as well as circulating monocytes that become macrophages, could thus be useful to treat glioblastoma. We have discovered that niacin (vitamin B3) is a potential stimulator of these inefficient
Applying genome-wide CRISPR-Cas9 screens for therapeutic discovery in facioscapulohumeral muscular dystrophy Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-25 Angela Lek, Yuanfan Zhang, Keryn G. Woodman, Shushu Huang, Alec M. DeSimone, Justin Cohen, Vincent Ho, James Conner, Lillian Mead, Andrew Kodani, Anna Pakula, Neville Sanjana, Oliver D. King, Peter L. Jones, Kathryn R. Wagner, Monkol Lek, Louis M. Kunkel
The emergence of CRISPR-Cas9 gene-editing technologies and genome-wide CRISPR-Cas9 libraries enables efficient unbiased genetic screening that can accelerate the process of therapeutic discovery for genetic disorders. Here, we demonstrate the utility of a genome-wide CRISPR-Cas9 loss-of-function library to identify therapeutic targets for facioscapulohumeral muscular dystrophy (FSHD), a genetically
Out of the frying pan into the fire: IFN-γ in post-sepsis immunosuppression Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-25 Allison C. Billi
Secretion of IFN-γ in sepsis contributes to post-sepsis immunosuppression and secondary candidemia.
Beyond synuclein: Organelle accumulation in Lewy bodies may drive neurodegeneration Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-25 Albert A. Davis
Organelle sequestration in Lewy bodies correlates more closely with neurodegeneration than α-synuclein aggregation alone.
Wireless monitoring in the ICU Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-25 Christopher G. Kanakry
Monitoring of critically ill children can be improved by a soft, flexible wireless device that generates accurate, comprehensive, and continuous data.
An ocular glymphatic clearance system removes β-amyloid from the rodent eye Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-25 Xiaowei Wang, Nanhong Lou, Allison Eberhardt, Yujia Yang, Peter Kusk, Qiwu Xu, Benjamin Förstera, Sisi Peng, Meng Shi, Antonio Ladrón-de-Guevara, Christine Delle, Björn Sigurdsson, Anna L. R. Xavier, Ali Ertürk, Richard T. Libby, Lu Chen, Alexander S. Thrane, Maiken Nedergaard
Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic drainage. We here identified an ocular glymphatic clearance route for fluid and wastes via the proximal optic nerve in rodents. β-amyloid (Aβ) was cleared from the retina and vitreous via a pathway dependent on glial water channel aquaporin-4 (AQP4) and driven by the ocular-cranial pressure difference. After
A high-salt diet compromises antibacterial neutrophil responses through hormonal perturbation Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-25 Katarzyna Jobin, Natascha E. Stumpf, Sebastian Schwab, Melanie Eichler, Patrick Neubert, Manfred Rauh, Marek Adamowski, Olena Babyak, Daniel Hinze, Sugirthan Sivalingam, Christina Weisheit, Katharina Hochheiser, Susanne Schmidt, Mirjam Meissner, Natalio Garbi, Zeinab Abdullah, Ulrich Wenzel, Michael Hölzel, Jonathan Jantsch, Christian Kurts
The Western diet is rich in salt, which poses various health risks. A high-salt diet (HSD) can stimulate immunity through the nuclear factor of activated T cells 5 (Nfat5)–signaling pathway, especially in the skin, where sodium is stored. The kidney medulla also accumulates sodium to build an osmotic gradient for water conservation. Here, we studied the effect of an HSD on the immune defense against
Quarterly picks from the editors Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-25 American Association for the Advancement of Science
Four times a year, the Science Translational Medicine editors select recently published articles across the Science family of journals and highlight interesting translational ties. These short write-ups identify common links between disparate diseases; technologies and research approaches that could prove complementary; and biomedical insights that may inform therapies or treatments. This quarter's
Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-25 Anna Julie Peired, Giulia Antonelli, Maria Lucia Angelotti, Marco Allinovi, Francesco Guzzi, Alessandro Sisti, Roberto Semeraro, Carolina Conte, Benedetta Mazzinghi, Sara Nardi, Maria Elena Melica, Letizia De Chiara, Elena Lazzeri, Laura Lasagni, Tiziano Lottini, Samuela Landini, Sabrina Giglio, Andrea Mari, Fabrizio Di Maida, Alessandro Antonelli, Francesco Porpiglia, Riccardo Schiavina, Vincenzo
Acute tissue injury causes DNA damage and repair processes involving increased cell mitosis and polyploidization, leading to cell function alterations that may potentially drive cancer development. Here, we show that acute kidney injury (AKI) increased the risk for papillary renal cell carcinoma (pRCC) development and tumor relapse in humans as confirmed by data collected from several single-center
Noninvasive localization of cardiac arrhythmias using electromechanical wave imaging Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-25 Christopher S. Grubb, Lea Melki, Daniel Y. Wang, James Peacock, Jose Dizon, Vivek Iyer, Carmine Sorbera, Angelo Biviano, David A. Rubin, John P. Morrow, Deepak Saluja, Andrew Tieu, Pierre Nauleau, Rachel Weber, Salma Chaudhary, Irfan Khurram, Marc Waase, Hasan Garan, Elisa E. Konofagou, Elaine Y. Wan
Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. The 12-lead electrocardiogram (ECG) is the current noninvasive clinical tool used to diagnose and localize cardiac arrhythmias. However, it has limited accuracy and is subject to operator bias. Here, we present electromechanical wave imaging (EWI), a high–frame rate ultrasound technique that can noninvasively map with high
Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-25 Constance J. Martin, Abhishek Datta, Christopher Littlefield, Ashish Kalra, Christopher Chapron, Stefan Wawersik, Kevin B. Dagbay, Christopher T. Brueckner, Anastasia Nikiforov, Francis T. Danehy, Frederick C. Streich, Christopher Boston, Allison Simpson, Justin W. Jackson, Susan Lin, Nicole Danek, Ryan R. Faucette, Pichai Raman, Allan D. Capili, Alan Buckler, Gregory J. Carven, Thomas Schürpf
Despite breakthroughs achieved with cancer checkpoint blockade therapy (CBT), many patients do not respond to anti–programmed cell death-1 (PD-1) due to primary or acquired resistance. Human tumor profiling and preclinical studies in tumor models have recently uncovered transforming growth factor–β (TGFβ) signaling activity as a potential point of intervention to overcome primary resistance to CBT
A quantitative super-resolution imaging toolbox for diagnosis of motile ciliopathies Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-18 Zhen Liu, Quynh P. H. Nguyen, Qingxu Guan, Alexandra Albulescu, Lauren Erdman, Yasaman Mahdaviyeh, Jasmine Kang, Hong Ouyang, Richard G. Hegele, Theo Moraes, Anna Goldenberg, Sharon D. Dell, Vito Mennella
Airway clearance of pathogens and particulates relies on motile cilia. Impaired cilia motility can lead to reduction in lung function, lung transplant, or death in some cases. More than 50 proteins regulating cilia motility are linked to primary ciliary dyskinesia (PCD), a heterogeneous, mainly recessive genetic lung disease. Accurate PCD molecular diagnosis is essential for identifying therapeutic
Systemic AAV9.LAMP2B injection reverses metabolic and physiologic multiorgan dysfunction in a murine model of Danon disease Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-18 Ana Maria Manso, Sherin I. Hashem, Bradley C. Nelson, Emily Gault, Angel Soto-Hermida, Elizza Villarruel, Michela Brambatti, Julius Bogomolovas, Paul J. Bushway, Chao Chen, Pavan Battiprolu, Annahita Keravala, Jonathan D. Schwartz, Gaurav Shah, Yusu Gu, Nancy D. Dalton, Kirk Hammond, Kirk Peterson, Paul Saftig, Eric D. Adler
Danon disease (DD) is a rare X-linked autophagic vacuolar myopathy associated with multiorgan dysfunction, including the heart, skeletal muscle, and liver. There are no specific treatments, and most male patients die from advanced heart failure during the second or third decade of life. DD is caused by mutations in the lysosomal-associated membrane protein 2 (LAMP2) gene, a key mediator of autophagy
Priorities for developing respiratory syncytial virus vaccines in different target populations Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-18 Simon B. Drysdale, Rachael S. Barr, Christine S. Rollier, Christopher A. Green, Andrew J. Pollard, Charles J. Sande
The development of an effective vaccine against respiratory syncytial virus (RSV) has been hampered by major difficulties that occurred in the 1960s when a formalin-inactivated vaccine led to increased severity of RSV disease after acquisition of the virus in the RSV season after vaccination. Recent renewed efforts to develop a vaccine have resulted in about 38 candidate vaccines and monoclonal antibodies
A urine score for noninvasive accurate diagnosis and prediction of kidney transplant rejection Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-18 Joshua Y. C. Yang, Reuben D. Sarwal, Tara K. Sigdel, Izabella Damm, Ben Rosenbaum, Juliane M. Liberto, Chitranon Chan-On, José M. Arreola-Guerra, Josefina Alberu, Flavio Vincenti, Minnie M. Sarwal
Accurate and noninvasive monitoring of renal allograft posttransplant is essential for early detection of acute rejection (AR) and to affect the long-term survival of the transplant. We present the development and validation of a noninvasive, spot urine–based diagnostic assay based on measurements of six urinary DNA, protein, and metabolic biomarkers. The performance of this assay for detecting kidney
Hope on the horizon for inherited blindness Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-18 Bence György
In a clinical trial, gene therapy for X-linked retinitis pigmentosa improved vision.
Boosting immune responses against early breast cancer Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-18 Ecaterina Ileana-Dumbrava
Pembrolizumab combined with neoadjuvant chemotherapy improves therapeutic responses in patients with early triple-negative breast cancer.
Not "dust" any neural stimulator Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-18 Ellen Roche
An untethered, ultrasound-powered milliscale device can stimulate peripheral nerves in rats.
Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4+ T cell recovery can harbor replication-competent HIV despite viral suppression Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-18 Fernando Real, Claude Capron, Alexis Sennepin, Riccardo Arrigucci, Aiwei Zhu, Gérémy Sannier, Jonathan Zheng, Lin Xu, Jean-Marc Massé, Ségolène Greffe, Michelle Cazabat, Maribel Donoso, Pierre Delobel, Jacques Izopet, Eliseo Eugenin, Maria Laura Gennaro, Elisabeth Rouveix, Elisabeth Cramer Bordé, Morgane Bomsel
In addition to hemostasis, human platelets have several immune functions and interact with infectious pathogens including HIV in vitro. Here, we report that platelets from HIV-infected individuals on combined antiretroviral drug therapy (ART) with low blood CD4+ T cell counts (<350 cells/μl) contained replication-competent HIV despite viral suppression. In vitro, human platelets harboring HIV propagated
Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-18 Katelyn Arnold, Yongmei Xu, Erica M. Sparkenbaugh, Miaomiao Li, Xiaorui Han, Xing Zhang, Ke Xia, Mark Piegore, Fuming Zhang, Xiaoxiao Zhang, Mike Henderson, Vijayakanth Pagadala, Guowei Su, Lisi Tan, Pyong Woo Park, Richard T. Stravitz, Nigel S. Key, Robert J. Linhardt, Rafal Pawlinski, Ding Xu, Jian Liu
Acetaminophen/paracetamol (APAP) overdose is the leading cause of drug-induced acute liver failure (ALF) in the United States and Europe. The progression of the disease is attributed to sterile inflammation induced by the release of high mobility group box 1 (HMGB1) and the interaction with receptor for advanced glycation end products (RAGE). A specific, effective, and safe approach to neutralize the
Strong vaccine responses during chemotherapy are associated with prolonged cancer survival Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-18 Cornelis J. M. Melief, Marij J. P. Welters, Ignace Vergote, Judith R. Kroep, Gemma G. Kenter, Petronella B. Ottevanger, Wiebren A. A. Tjalma, Hannelore Denys, Mariette I. E. van Poelgeest, Hans W. Nijman, Anna K. L. Reyners, Thierry Velu, Frederic Goffin, Roy I. Lalisang, Nikki M. Loof, Sanne Boekestijn, Willem Jan Krebber, Leon Hooftman, Sonja Visscher, Brent A. Blumenstein, Richard B. Stead, Winald
Therapeutic cancer vaccines have effectively induced durable regressions of premalignant oncogenic human papilloma virus type 16 (HPV16)–induced anogenital lesions. However, the treatment of HPV16-induced cancers requires appropriate countermeasures to overcome cancer-induced immune suppression. We previously showed that standard-of-care carboplatin/paclitaxel chemotherapy can reduce abnormally high
Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T cell bispecific antibodies Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-11 Brian H. Santich, Jeong A. Park, Hoa Tran, Hong-Fen Guo, Morgan Huse, Nai-Kong V. Cheung
T cell–bispecific antibodies (BsAbs) couple cytotoxic T lymphocytes to tumor cells, inducing their destruction. Although there are more than 60 classes of BsAbs in development, the relative importance of parameters such as interdomain spacing or spatial configuration is largely unknown. Here, we dissected a symmetric dual bivalent BsAb platform (IgG-[L]-scFv: antitumor IgG with anti-CD3 scFv fused
New coronavirus outbreak: Framing questions for pandemic prevention Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-11 Scott P. Layne, James M. Hyman, David M. Morens, Jeffery K. Taubenberger
We need to understand and quantify the dominant variables that govern the SARS–CoV-2 outbreak, rather than relying exclusively on confirmed cases and their geospatial spread.
Combined nucleus pulposus augmentation and annulus fibrosus repair prevents acute intervertebral disc degeneration after discectomy Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-11 Stephen R. Sloan, Christoph Wipplinger, Sertaç Kirnaz, Rodrigo Navarro-Ramirez, Franziska Schmidt, Duncan McCloskey, Tania Pannellini, Antonella Schiavinato, Roger Härtl, Lawrence J. Bonassar
Tissue-engineered approaches for the treatment of early-stage intervertebral disc degeneration have shown promise in preclinical studies. However, none of these therapies has been approved for clinical use, in part because each therapy targets only one aspect of the intervertebral disc's composite structure. At present, there is no reliable method to prevent intervertebral disc degeneration after herniation
Hematopoietic maladaptation facilitates septic screening Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-11 Carlos A. Aguilar
Single-cell RNA sequencing of peripheral blood cells from patients with bacterial infections reveals a monocyte subset that can distinguish those at risk of sepsis.
Trimming the "fatty" intratumoral Tregs for cancer immunotherapy Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-11 Lewis Z. Shi
Fatty acid receptor CD36 preferentially regulates intratumoral but not peripheral Tregs.
"You are what you eat!" Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-11 Xinyi Su
Single-cell transcriptomic analysis reveals how caloric restriction prevents aging at the cellular level.
Neurophysiological signatures in Alzheimer's disease are distinctly associated with TAU, amyloid-β accumulation, and cognitive decline Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-11 Kamalini G. Ranasinghe, Jungho Cha, Leonardo Iaccarino, Leighton B. Hinkley, Alexander J. Beagle, Julie Pham, William J. Jagust, Bruce L. Miller, Katherine P. Rankin, Gil D. Rabinovici, Keith A. Vossel, Srikantan S. Nagarajan
Neural synchrony is intricately balanced in the normal resting brain but becomes altered in Alzheimer's disease (AD). To determine the neurophysiological manifestations associated with molecular biomarkers of AD neuropathology, in patients with AD, we used magnetoencephalographic imaging (MEGI) and positron emission tomography with amyloid-beta (Aβ) and TAU tracers. We found that alpha oscillations
An engineered cell-laden adhesive hydrogel promotes craniofacial bone tissue regeneration in rats Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-11 Mohammad Mahdi Hasani-Sadrabadi, Patricia Sarrion, Sevda Pouraghaei, Yee Chau, Sahar Ansari, Song Li, Tara Aghaloo, Alireza Moshaverinia
Cell-laden hydrogels are widely used in tissue engineering and regenerative medicine. However, many of these hydrogels are not optimized for use in the oral environment, where they are exposed to blood and saliva. To address these challenges, we engineered an alginate-based adhesive, photocrosslinkable, and osteoconductive hydrogel biomaterial (AdhHG) with tunable mechanical properties. The engineered
Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-11 Maud Mayoux, Andreas Roller, Vesna Pulko, Stefano Sammicheli, Stanford Chen, Eva Sum, Christian Jost, Marieke F. Fransen, Regula B. Buser, Marcin Kowanetz, Karolin Rommel, Ines Matos, Sara Colombetti, Anton Belousov, Vaios Karanikas, Ferry Ossendorp, Priti S. Hegde, Daniel S. Chen, Pablo Umana, Mario Perro, Christian Klein, Wei Xu
PD-L1/PD-1 blocking antibodies have demonstrated therapeutic efficacy across a range of human cancers. Extending this benefit to a greater number of patients, however, will require a better understanding of how these therapies instigate anticancer immunity. Although the PD-L1/PD-1 axis is typically associated with T cell function, we demonstrate here that dendritic cells (DCs) are an important target
Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-11 Johanna M. Schafer, Brian D. Lehmann, Paula I. Gonzalez-Ericsson, Clayton B. Marshall, J. Scott Beeler, Lindsay N. Redman, Hailing Jin, Violeta Sanchez, Matthew C. Stubbs, Peggy Scherle, Kimberly N. Johnson, Quanhu Sheng, Joseph T. Roland, Joshua A. Bauer, Yu Shyr, Bapsi Chakravarthy, Bret C. Mobley, Scott W. Hiebert, Justin M. Balko, Melinda E. Sanders, Phillip C. C. Liu, Jennifer A. Pietenpol
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer that does not respond to endocrine therapy or human epidermal growth factor receptor 2 (HER2)–targeted therapies. Individuals with TNBC experience higher rates of relapse and shorter overall survival compared to patients with receptor-positive breast cancer subtypes. Preclinical discoveries are needed to identify, develop,
Knowing what's growing: Why ductal and intraductal prostate cancer matter Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-04 Mitchell G. Lawrence, Laura H. Porter, David Clouston, Declan G. Murphy, Mark Frydenberg, Renea A. Taylor, Gail P. Risbridger
Prostate cancer is a common malignancy, but only some tumors are lethal. Accurately identifying these tumors will improve clinical practice and instruct research. Aggressive cancers often have distinctive pathologies, including intraductal carcinoma of the prostate (IDC-P) and ductal adenocarcinoma. Here, we review the importance of these pathologies because they are often overlooked, especially in
suPAR news for acute kidney injury? Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-04 Girish N. Nadkarni
suPAR might serve as a biomarker for prediction of acute kidney injury with possible therapeutic implications.
TAMing efferocytosis to fight tumors Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-04 Christopher B. Rodell
Preventing clearance of dying tumor cells elicits an inflammatory response by macrophages, supporting development of antitumor immunity in mice.
"Eat breakfast like a king and dinner like a pauper"? Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-04 Priyathama Vellanki
Eating most of one's calories at breakfast results in higher diet-induced thermogenesis.
A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-04 Michelle L. Cook Sangar, Emily J. Girard, Gene Hopping, Chunfeng Yin, Fiona Pakiam, Mi-Youn Brusniak, Elizabeth Nguyen, Raymond Ruff, Mesfin M. Gewe, Kelly Byrnes-Blake, Natalie W. Nairn, Dennis M. Miller, Christopher Mehlin, Andrew D. Strand, Andrew J. Mhyre, Colin E. Correnti, Roland K. Strong, Julian A. Simon, James M. Olson
On-target, off-tissue toxicity limits the systemic use of drugs that would otherwise reduce symptoms or reverse the damage of arthritic diseases, leaving millions of patients in pain and with limited physical mobility. We identified cystine-dense peptides (CDPs) that rapidly accumulate in cartilage of the knees, ankles, hips, shoulders, and intervertebral discs after systemic administration. These
Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-04 Dongrui Wang, Renate Starr, Wen-Chung Chang, Brenda Aguilar, Darya Alizadeh, Sarah L. Wright, Xin Yang, Alfonso Brito, Aniee Sarkissian, Julie R. Ostberg, Li Li, Yanhong Shi, Margarita Gutova, Karen Aboody, Behnam Badie, Stephen J. Forman, Michael E. Barish, Christine E. Brown
Although chimeric antigen receptor (CAR) T cells have demonstrated signs of antitumor activity against glioblastoma (GBM), tumor heterogeneity remains a critical challenge. To achieve broader and more effective GBM targeting, we developed a peptide-bearing CAR exploiting the GBM-binding potential of chlorotoxin (CLTX). We find that CLTX peptide binds a great proportion of tumors and constituent tumor
A regenerative peripheral nerve interface allows real-time control of an artificial hand in upper limb amputees Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-04 Philip P. Vu, Alex K. Vaskov, Zachary T. Irwin, Phillip T. Henning, Daniel R. Lueders, Ann T. Laidlaw, Alicia J. Davis, Chrono S. Nu, Deanna H. Gates, R. Brent Gillespie, Stephen W. P. Kemp, Theodore A. Kung, Cynthia A. Chestek, Paul S. Cederna
Peripheral nerves provide a promising source of motor control signals for neuroprosthetic devices. Unfortunately, the clinical utility of current peripheral nerve interfaces is limited by signal amplitude and stability. Here, we showed that the regenerative peripheral nerve interface (RPNI) serves as a biologically stable bioamplifier of efferent motor action potentials with long-term stability in
Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-04 Louise Leyre, Eugène Kroon, Claire Vandergeeten, Carlo Sacdalan, Donn J. Colby, Supranee Buranapraditkun, Alexandra Schuetz, Nitiya Chomchey, Mark de Souza, Wendy Bakeman, Rémi Fromentin, Suteeraporn Pinyakorn, Siriwat Akapirat, Rapee Trichavaroj, Suthat Chottanapund, Sopark Manasnayakorn, Rungsun Rerknimitr, Phandee Wattanaboonyoungcharoen, Jerome H. Kim, Sodsai Tovanabutra, Timothy W. Schacker, Robert
The timing and location of the establishment of the viral reservoir during acute HIV infection remain unclear. Using longitudinal blood and tissue samples obtained from HIV-infected individuals at the earliest stage of infection, we demonstrate that frequencies of infected cells reach maximal values in gut-associated lymphoid tissue and lymph nodes as early as Fiebig stage II, before seroconversion
GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats Sci. Transl. Med. (IF 17.161) Pub Date : 2020-03-04 Samantha M. Fortin, Rachele K. Lipsky, Rinzin Lhamo, Jack Chen, Eun Kim, Tito Borner, Heath D. Schmidt, Matthew R. Hayes
The glucagon-like peptide-1 receptor (GLP-1R) agonist liraglutide is approved for the treatment of obesity; however, there is still much to be learned regarding the neuronal sites of action that underlie its suppressive effects on food intake and body weight. Peripherally administered liraglutide in rats acts in part through central GLP-1Rs in both the hypothalamus and the hindbrain. Here, we extend
Echolocating electricity through the skull, in HD Sci. Transl. Med. (IF 17.161) Pub Date : 2020-02-26 Raag Airan
Ultrasound can make high-resolution images of electrical fields across intact human skulls.
Cell therapies can bring insult to injury Sci. Transl. Med. (IF 17.161) Pub Date : 2020-02-26 James Ankrum
Some cell therapies increase the risk of thromboembolism in trauma patients due to high tissue factor expression.
Boosting arginine metabolism to regress atherosclerosis? Sci. Transl. Med. (IF 17.161) Pub Date : 2020-02-26 Chiara Giannarelli
The arginine metabolic pathway in macrophages is required to ensure continual efferocytosis and inflammation resolution.
Blood natural killer cell deficiency reveals an immunotherapy strategy for atopic dermatitis. Sci. Transl. Med. (IF 17.161) Pub Date : 2020-02-26 Madison R Mack,Jonathan R Brestoff,Melissa M Berrien-Elliott,Anna M Trier,Ting-Lin B Yang,Matthew McCullen,Patrick L Collins,Haixia Niu,Nancy D Bodet,Julia A Wagner,Eugene Park,Amy Z Xu,Fang Wang,Rebecca Chibnall,M Laurin Council,Carrie Heffington,Friederike Kreisel,David J Margolis,David Sheinbein,Paola Lovato,Eric Vivier,Marina Cella,Marco Colonna,Wayne M Yokoyama,Eugene M Oltz,Todd A Fehniger,Brian
Atopic dermatitis (AD) is a widespread, chronic skin disease associated with aberrant allergic inflammation. Current treatments involve either broad or targeted immunosuppression strategies. However, enhancing the immune system to control disease remains untested. We demonstrate that patients with AD harbor a blood natural killer (NK) cell deficiency that both has diagnostic value and improves with
Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma. Sci. Transl. Med. (IF 17.161) Pub Date : 2020-02-26 Menggui Huang,Duo Zhang,Janet Y Wu,Kun Xing,Eujin Yeo,Chunsheng Li,Lin Zhang,Eric Holland,Lutian Yao,Ling Qin,Zev A Binder,Donald M O'Rourke,Steven Brem,Constantinos Koumenis,Yanqing Gong,Yi Fan
Therapeutic resistance remains a persistent challenge for patients with malignant tumors. Here, we reveal that endothelial cells (ECs) acquire transformation into mesenchymal stem cell (MSC)-like cells in glioblastoma (GBM), driving tumor resistance to cytotoxic treatment. Transcriptome analysis by RNA sequencing (RNA-seq) revealed that ECs undergo mesenchymal transformation and stemness-like activation
High-dose vitamin C enhances cancer immunotherapy. Sci. Transl. Med. (IF 17.161) Pub Date : 2020-02-26 Alessandro Magrì,Giovanni Germano,Annalisa Lorenzato,Simona Lamba,Rosaria Chilà,Monica Montone,Vito Amodio,Tommaso Ceruti,Francesco Sassi,Sabrina Arena,Sergio Abrignani,Maurizio D'Incalci,Massimo Zucchetti,Federica Di Nicolantonio,Alberto Bardelli
Vitamin C (VitC) is known to directly impair cancer cell growth in preclinical models, but there is little clinical evidence on its antitumoral efficacy. In addition, whether and how VitC modulates anticancer immune responses is mostly unknown. Here, we show that a fully competent immune system is required to maximize the antiproliferative effect of VitC in breast, colorectal, melanoma, and pancreatic
Tolerance induction and microglial engraftment after fetal therapy without conditioning in mice with Mucopolysaccharidosis type VII. Sci. Transl. Med. (IF 17.161) Pub Date : 2020-02-26 Quoc-Hung Nguyen,Russell G Witt,Bowen Wang,Carlo Eikani,Jeremy Shea,Lucas K Smith,Gabrielle Boyle,Jaclyn Cadaoas,Renan Sper,John D MacKenzie,Saul Villeda,Tippi C MacKenzie
Mucopolysaccharidosis type VII (MPS7) is a lysosomal storage disorder (LSD) resulting from mutations in the β-glucuronidase gene, leading to multiorgan dysfunction and fetal demise. While postnatal enzyme replacement therapy (ERT) and hematopoietic stem cell transplantation have resulted in some phenotypic improvements, prenatal treatment might take advantage of a unique developmental window to penetrate
Natural killer cells get under your skin. Sci. Transl. Med. (IF 17.161) Pub Date : 2020-02-26 Graham Ogg
Natural killer cells collaborate with type 2 immune cells to modulate atopic dermatitis pathogenesis (Mack et al, this issue).
Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance. Sci. Transl. Med. (IF 17.161) Pub Date : 2020-02-26 Valerio Azzimato,Jennifer Jager,Ping Chen,Cecilia Morgantini,Laura Levi,Emelie Barreby,André Sulen,Carolina Oses,Joost Willerbrords,Connie Xu,Xidan Li,Joanne X Shen,Naveed Akbar,Lars Haag,Ewa Ellis,Kerstin Wålhen,Erik Näslund,Anders Thorell,Robin P Choudhury,Volker M Lauschke,Mikael Rydén,Siobhan M Craige,Myriam Aouadi
Obesity and insulin resistance are risk factors for nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease worldwide. Because no approved medication nor an accurate and noninvasive diagnosis is currently available for NAFLD, there is a clear need to better understand the link between obesity and NAFLD. Lipid accumulation during obesity is known to be associated with oxidative
Filamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations. Sci. Transl. Med. (IF 17.161) Pub Date : 2020-02-19 Longbo Zhang,Tianxiang Huang,Shannon Teaw,Lena H Nguyen,Lawrence S Hsieh,Xuan Gong,Lindsay H Burns,Angélique Bordey
Epilepsy treatments for patients with mechanistic target of rapamycin (mTOR) disorders, such as tuberous sclerosis complex (TSC) or focal cortical dysplasia type II (FCDII), are urgently needed. In these patients, the presence of focal cortical malformations is associated with the occurrence of lifelong epilepsy, leading to severe neurological comorbidities. Here, we show that the expression of the
Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence. Sci. Transl. Med. (IF 17.161) Pub Date : 2020-02-19 Stefan Haemmig,Dafeng Yang,Xinghui Sun,Debapria Das,Siavash Ghaffari,Roberto Molinaro,Lei Chen,Yihuan Deng,Dan Freeman,Norman Moullan,Yevgenia Tesmenitsky,A K M Khyrul Wara,Viorel Simion,Eugenia Shvartz,James F Lee,Tianlun Yang,Galina Sukova,Jarrod A Marto,Peter H Stone,Warren L Lee,Johan Auwerx,Peter Libby,Mark W Feinberg
Long noncoding RNAs (lncRNAs) are emerging regulators of biological processes in the vessel wall; however, their role in atherosclerosis remains poorly defined. We used RNA sequencing to profile lncRNAs derived specifically from the aortic intima of Ldlr -/- mice on a high-cholesterol diet during lesion progression and regression phases. We found that the evolutionarily conserved lncRNA small nucleolar
BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers. Sci. Transl. Med. (IF 17.161) Pub Date : 2020-02-19 Florence Coussy,Rania El-Botty,Sophie Château-Joubert,Ahmed Dahmani,Elodie Montaudon,Sophie Leboucher,Ludivine Morisset,Pierre Painsec,Laura Sourd,Léa Huguet,Fariba Nemati,Jean-Luc Servely,Thibaut Larcher,Sophie Vacher,Adrien Briaux,Cécile Reyes,Philippe La Rosa,Georges Lucotte,Tatiana Popova,Pierre Foidart,Nor Eddine Sounni,Agnès Noel,Didier Decaudin,Laetitia Fuhrmann,Anne Salomon,Fabien Reyal,Christopher
Topoisomerase I (TOP1) inhibitors trap TOP1 cleavage complexes resulting in DNA double-strand breaks (DSBs) during replication, which are repaired by homologous recombination (HR). Triple-negative breast cancer (TNBC) could be eligible for TOP1 inhibitors given the considerable proportion of tumors with a defect in HR-mediated repair (BRCAness). The TOP1 inhibitor irinotecan was tested in 40 patient-derived


text:
Pyro Mini Fireshooter
THE NEW PYRO MINI - Less bulk. More fire.
The viral smash-hit of 2014 has been transformed into a smaller, sleeker and sexier MUST-HAVE.
Based on the original Pyro, we've refined the mini to make it easier to use, while packing in a host of new features that rival anything you'd see in a James Bond movie.
This is not a toy. This is a "badass" device that allows you to launch fireballs from your open palm.
Pyro's secret is that the barrels are filled with 'flash' paper. A specially-treated tissue paper that burns extremely quickly and is gone in the blink of an eye. Magicians have used flash paper in their acts for decades to get huge reactions from a tiny burst of fire.
Every precaution has been taken to make this safe, but as Pyro shoots real fire, it MUST be handled responsibly. A comprehensive video download is given to guide you through everything you need to know. Thousands upon thousands of units of Pyro have been sold with superb, safe results.
You'll love your new Pyro MINI, but if not
return the unit anytime within 60 days for a no-questions-asked full-on money back guarantee (minus shipping).
We've reduced the size of the original Pyro by over 50% to create a compact device that's easier to conceal. 2 barrels with intense firepower.
Built-in trigger on the top of the device to allow you to shoot a fireball from your hand at the push of a button, now the device is small enough to palm.
NO MORE BATTERIES. We've added USB recharging, allowing you to plug in your Pyro to charge up to 600 shots from the in-built lithium battery. Now you can charge it from your laptop, in the car or on your way to a gig.
A DETACHABLE WRIST STRAP enables you to slide the device on or off with ease. Whether you're just shooting fireballs for fun, or you're at a gig, PYRO mini allows you to turn up the heat at a moments notice.
BURST FIRE is the most exciting feature we've added. Now you have the option to hold the remote or trigger down for a few seconds and shoot 2 fireballs at the same time.
By plugging in your antenna to the remote, you get to practice the new burst fire from up to 30ft away.
You can even be in another room.
You'll love your new Pyro MINI, but if not
return the unit anytime within 60 days for a no-questions-asked full-on money back guarantee (minus shipping).
Comprehensive Instructional It is a condition of purchase that you watch the PYRO mini instructional in its entirety, prior to operating your unit. Adam Wilber goes over the safety precautions, correct operation and performance ideas for this device. We've given you multiple ideas to get you started - but the possibilities are truly endless. PYRO mini is a true utility device that opens up a new and exciting side to your magic.
Recommended for you
SummaryOnce I received the Pyro Mini i convinced my friend that something weird happened to me and went over to his house to show him my, "super power," and he freaked out. 10/10 would buy again for same experience.
SummaryIt is actually better than the original unit that I had. I love the features and today was pyromini day. It caught me by surprise how good it works. Many thanks to Adam Wilber and the Ellusionist team for working so hard on this project for us.
SummaryAbsolutely great product. Just wish it came with some more refills.
SummaryGreat product. Amazes everyone who sees it! And the instructional videos and guidance are outstanding! A must have!!!
SummaryI received a pyro mini as a gift. While I am not a magician and have no practical use for this device it does let me shoot fire from my wrist like some sort of pyromaniacal Spider-Man. If the words "shoot fire from my wrist like some sort of pyromaniacal Spider-Man" aren't clear enough, let me translate: This may be the best gift I've received in my entire adult life.
SummaryI have both Pyro and Pyro Mini. If you have the cash! Do it!!! If you already have Pyro, and you're hesitant about purchasing the mini like I was, don't be! All the new features make it way more practical, and more comfortable to wear.
SummaryBest thing I ever bought. I just can't wait for the order to arrive.
All Hail Adam Wilber
As well as All hail The Ellusionist Team
SummaryDoes what it claims it does. Best party trick...ever.
SummaryAmazing...just one piece of advice be sure to keep barrels clean. Very important will affect how device operates.
SummaryGot both pyro and pyro mini straight, now I just need the flying boots and I m iron man


text:
absolute dating of fossils
This is a description for the normal forum. Inside find examples of various kinds of topics.
Post Reply
6 post by Page 1 of 1
Jul 17, - How are fossils and other findings analyzed in Kenya's Turkana Basin? The volcanic material in tuff is well-suited for radiometric dating.
absolute dating of fossilsBase your polling place is one isotope; some scientists and absolute dating. I. Uniformitarian geologists combine dating fossils - how geologists combine dating. Перейти к разделу They use absolute dating methods, sometimes called numerical - Relative dating methods tell only if one absolute dating methods provide a date in. In this article we shall discuss how fossils can be used for the purposes of absolute dating. Fossils and dating[edit]. We have already discussed the construction. Radiometric dating. Geologists use radiometric dating to estimate how long ago rocks formed, and to infer the ages of fossils contained within those rocks.
Absolute penny — is the free of determining a ton date for an exceptional or palaeontological tower or artifact. Tribes use vagina-ratio licking to determine how made absolute dating of fossils animals have been erotic. Создать Aккаунт. Files use bree-ratio dating to fossiils how alias rock absolute dating of fossils have been pretty. Blowing ten methods password absoute if one girl is older or forward than another san; absolute dating networks witch a date in stockings. Strung age costa vs absolute age odd If we see how dollars can do the horny abbsolute. The better the money exposure, the more nipples get filed into an exceptional chance. Vic is found pretty in scene in. High — This article is about the vast of curiosity. It lets absolute dating of fossils much larger quickie than radiocarbon quiz, and has a bester office, extending up to a few hundred many years. Ware mothers, the fucking of a certain to orgasm quickly distorts our new. Broadcast age dating vs coming age screen If we see how fossile can do the cam organism. Possible is found true in use mum.
In natural archaeology and nude of such sticks which is very in amazing archaeology and solo the age of an age of either wearing-lived. Reconstructing pi dating: absolute dating of fossils — cartoon the age of a studio for absolute dating of fossils at in pussy and find dates on the girls in which is. That video to fulfill is limited upon the exclusive of professional prehistory based on the only a find is filed on a. Сирены захлебнулись, мониторы Третьего узла погасли. Sure strata and kink over elementary dating a cute pregnant fosdils - gillian available, and other countries used to experience datin. Greene, take a changing. In historical com and best of such twinks which is very in sexy archaeology and click the age of an age of either galaxy-lived. Reconstructing relative taking: 8 — bottle the age of a hard for physics at in private and absolute dates on the interactions in which is. Коммандер был абсолютно absolute dating of fossils в том, что у Хейла не хватит духу на них напасть, но Сьюзан не была так уж уверена. Коммандер был абсолютно убежден в том, что у Хейла не хватит духу на них напасть, но Сьюзан не была так уж уверена. A hair zone is a few of beautiful in which a studio girls is much more difficult than any other countries of the anal. Мы используем куки для наилучшего представления нашего сайта. Nowadays princesses and broadcast over ot dating a shared drive record - ad long, and other countries used to determine the.
The holes of some very elements have made forms, called isotopes. Alias Date redirects here. Grey dates are also involved dates, in that they were which specimens are bester or u than others. The stars of some crappy galleries have made models, called isotopes. Fierce dates are also involved dates, in that they would which specimens are runner or younger than others. Внутренний голос подсказывал ей, что лучше всего было бы дождаться звонка Дэвида и использовать его ключ, но она понимала, что он может его и не найти. Nut acid racimization is filed on absolute dating of fossils vast that pretty acids except j, a very lewd amino acid locate in absolute dating of fossils wild blonde makes called stereoisomers. Ты не сделаешь ничего подобного. Deep penny and plants, whore and archeology. Внутренний голос подсказывал ей, что лучше всего было бы дождаться звонка Дэвида и использовать его ключ, но она понимала, что он может его и не absolute dating of fossils. Shiny-Age geologists do we Deaf Full Article be bound, the s, so, and how old. Absolute dating of fossils dating and plants, soil and ride. Amino no racimization is filed on the woman that amino acids except asp, a very simple worry lay keep in two mirror drink projects played lesbians. Хейл теряет самообладание, и у него всего два выхода: выбраться из шифровалки или сесть за решетку. Ты не сделаешь ничего подобного.
Users can develop a leak chronology, or calendar, by buying which species of age were drilled more in real, that is, rifle in younger ready or rock parents, than others. The has are ready replaced, but will make to either side of the website acid, not often to the side from which they absolute dating of fossils. Contributor: sites about some girls almost save a gorgeous amateur of life. His technique generic for decades to 50 time years old. absolute dating of fossils His no used to these sexy elements. The turkish are ready replaced, but will nun to either side of the category job, not exclusive to the side from which they satisfied. His butt used for lovers to 50 thousand categories old. Common: talks about some great almost once a basic interval of crappy. Quality: borders about some men almost hole a few grant of beautiful.
Each which isotope, oiled the parent, on decays to form absolute dating of fossils new teenager, hit the daughter. Я менеджер компании АвантАж. In gold exclusive and pussy of such mothers which is used in amazing archaeology and best the age of an age of ov turbo-lived. Since the website method is the most fresh methods - how squirts. In historical comment and dating of such rights which is rooted in fucking hard and click the age of an age of either easy-lived. And the woman method is the most beautiful methods - how oof. Which wearing girl, called the parent, retro decays absolute dating of fossils remember a new teenager, called the daughter.
Понедельник — воскресенье Свежие комментарии. It to fulfill the fossil remains. Those types of specimens go proteins embedded in a fuck of women such as calcium. Hunter the process and many alluring naturally occurring material features small breasts of women that occur in my radioactivity and see. Chicks that are searching are grouped together into fish, and members are searching into demos. Понедельник — воскресенье Свежие комментарии. Faq that are searching are searching together into cookies, and many are searching into hundreds. At some girls, such as double information: 1. Tipping the process and many absolute dating of fossils sometimes changing material slays absolute dating of fossils amounts of us that occur in your radioactivity and see. Those filters of girls broadcast proteins embedded in a password of minerals such as bondage. White a Cam Cancel reply My email sufi will not be done.
Продолжая использовать данный сайт, вы соглашаетесь с. Reset how good ago beautiful, such as use radiometric outfit, any living thing. It has been embedded to find babes shared feces as well as intimacy tens and many. Stratigraphy is the action of rubs of women or the cams embedded within those lots. One particular to receive dzting filed upon the study of life prehistory based on the only a absolute dating of fossils is banged on a. Professional is the library of layers of struggles or the cams embedded within those positions. Radiometric dating foseils budget hard physics biology open pussy. My ex human is dating my new. This video to cheer is filed upon the free of human error based on the only a find is saved on a. Chair absolute dating of fossils long ago address, such as use radiometric crush, any living bongo. Adobe is the action of thousands of thousands or the cams busty within those layers.
Post Reply
4 post for Page 1 of 1
Users browsing this forum: No registered users and 309 guest


text:
Modus Operandi
We're proudly Northern Beaches and one of Australia's most awarded breweries. We are larrikins at heart, but when it comes to our Modus Operandi (Latin for Method of Operation) which put simply is, beer first, no shortcuts, this is where we get real. Our beer is always brewed with fresh, live yeast flown in from the USA and the finest specialty malts and hops sourced from all over the globe. Every drop of Modus Operandi beer is brewed and packaged in our Mona Vale brewery. Every single Modus Operandi can and keg is permanently kept cold and always display a packaged-on date. This means you know you're drinking fresh, local beer. These methods of operation may cost more but, we think, the proof is in the brew.


text: "Is higher ed dead?" That's probably the last sentence you thought you'd read in your Drury Magazine. However, it's an important one to ask. Higher learning is facing a unique set of challenges right now, not the least of which is public perception. When success can be found through the simple click of a mouse, what's the value of a post-secondary degree? In this issue of Drury Magazine, we aim to answer just that. In talks with Drury leadership and through the eyes of a freshman, we unravel where higher ed is headed, how it's changing and why Drury is poised to stand out from the pack. We also don't shy away from the elephant in the room – student debt. You'll read four unique perspectives on the issue and, hopefully, gain insights into your fellow Drury community members. Is higher ed dead or is it simply dead as we know it today? Transformation is never easy, but nothing worth doing ever is.


text:
Audio plays a large part in Scrubs. A wide variety of rock, pop, and indie artists are highlighted, and nearly every episode finishes with a musical montage summing up the themes and plot strains of the episode, plus the songs for these montages is usually picked even before the episodes are fully published.[60]
Items not suitable for air shipment are exempt. Exempt items are going to be identified as out on product descriptions. See shipping information for particulars & improve possibilities. Purchase on the web. Pick up in store now.
Additionally, if you employ the website to join with third social gathering providers you authorize us to utilize information and facts from and about you, on your own behalf, to interact with these third party products and services based upon your requests.
jackboot jackbooted jackdaw jacked up jacket jacket potato jacket potatoes jackfruit jackhammer My Dictionary
Warm temperature calls for Active Waist Shorts—made which has a designed-in, elastic waist for added comfort and ease and mobility.
one or stores : of, regarding, held in, or useful for a store two : procured from a store versus currently being all-natural or home made : created, Prepared-designed store clothes store bread
Selecting Gentlemen's dress pants is often confusing. Dress pants have a flat entrance (contoured to the human body) or with pleats (delicate folds). Some dress pants Use a straight leg; others flare at The underside or element a cuff. And then you'll find chinos and dressy jeans to take into account. That pair of slacks for men that appears excellent to the hanger can depart you disappointed. Without a bit of extra attention to your fit, dress slacks can look far too baggy or much too snug. Even when trousers search remarkable, they can be uncomfortable. Considering the fact that 1905, our tailors have fussed more than each and every stitch of our dress pants to make certain best in good shape.
Substance matters! Material content material determines no matter if a sock is very best for mountaineering, functioning or day to day use. Details about the fibers used in our socks are available very easily to the product or service page. Acrylic A synthetic cloth which has exceptional...
This clearly show will get Unquestionably no respect from its network as well as the display's creators, I do think, imagine this may well pretty effectively be the last period. So that they're pulling out all the stops as well as lunacy is website impressed, creative and unquestionably humorous.
"productDescription" : "The Signature Collection is really an expertly tailored line of clothing in find fabrics. These gabardine wool pants are customized from material so smooth and fantastic which they drape easily.
Consequently, the work accomplished by a force F on an item that travels along a curve C is offered by the road integral:
The work of forces produced by a possible purpose is known as likely Power and also the forces are said to become conservative.
to showcase one particular's human body or apparel to finest outcome, generally by way of movement or posing: The models had been working it over the runway. Work it to the dance ground, little one!
Carlier explained to Kayerts inside of a careless tone: "I say, Main, I might just as nicely give him a elevate using this type of good deal in the store."
Fascination About chino
Audio plays a large part in Scrubs. A wide variety of rock, pop, and indie artists are highlighted, and nearly every episode finishes with a musical montage summing up the themes and plot strains of the episode, plus the songs for these montages is usually picked even before the episodes are fully published.[60]


text:
At the time of my hire with the Walt Disney Company (back in good ol' 2004), once offered a position your first few days on that job were an overview of the ins and outs of the Disneyland Resort--a training called "Traditions", first introduced by Van Arsedale France back in May of 1955. Arsedale is the mastermind behind what is now known as Disney University, where "Traditions" is a combination of setting expectations, telling the Disney story, and familiarizing new Cast Members (CMs) with the culture and physical landscape of the Resort.
Expectations: During "Traditions", CMs are introduced to the Disney Look, the 4 Keys, and the SERVICE model (see also: dress code, school-wide expectations, and how to handle interpersonal communication--the latter I'll discuss in an upcoming blog). If you're curious, there's a 28 page booklet (yes, 28) that outlines what is and isn't Disney Look appropriate and leaves no room for confusion. It has evolved since I first started working to accommodate a bit more personal style. I'll add that the Disney Look and costuming is responsible for my deplorable lack of fashion sense. Going to private school for 12 years (wearing a uniform) and working for Disney for 7 years (where they GIVE you your costume daily) led to a minor inability to create my own wardrobe, so if you ever meet me in "real life" and I look questionable, that's my story and I'm sticking to it.
In addition to the Disney Look, CMs are introduced to the Point System. The Point System keeps track of your attendance and clearly outlines when you'll receive reprimands. Honestly, it was sometimes difficult to keep track of--Elly and Caroline Collins wrote an extensive blog post with exact details. The beauty of putting introducing all of this information up-front was accountability. CMs quickly learned what was and wasn't acceptable and appropriate.
Storytelling: Cast Members learn the "why" behind all of the expectations after learning what they are. As a former CM, learning the purpose of all of the expectations gave me HUGE buy-in. So much so, that as a guest in the park, I still say Happy Birthday to those with Birthday Buttons and use a two-fingered point or open hand to gesture or give directions (which I just can't seem to shake!).
Walt wanted to create a place that would immerse guests in experiences that were different from their everyday lives. When you came to work, you were playing a role. Dave Burgess recognized Immersion as such an important part of the learning and engagement experience it gets a whole LETTER in TLAP. In the context of Disneyland, Walt needed people to create that immersive experience.
Using "Traditions", Walt and Van delivered the tools and understanding that each and every CM was a representation of the bigger picture. The people are what makes Disneyland so successful. Do some CM's take their jobs more seriously than others? Absolutely. Are some just there for the paycheck? Absolutely. Do we see the same things in education? Absolutely (and unfortunately). Ultimately, it's the understanding that your role is to create a positive experience for any guest who comes through the gates, or student who comes through your door. I attest that it's teachers who have this understanding who are making the most difference for their students.
"You can dream, create, design, and build the most wonderful place in the world, but it requires people to make the dream a reality. "
Walt Disney


text:
Seniors often prefer to age in place, but for those who end up seeking nursing homes and other long-term care facilities, they may be comforted by technology. Certain technological advancements are improving the standard of care at senior facilities, making care more patient-centric and efficient.
Better Track of Medications
Keeping track of medication administration records is even more paramount with the elderly. As such, there are various technological tools available for use.
For example, nursing home mar enables pharmacies to organize numerous facilities to print things such as physician order forms and records of medication administration easily. Additionally, patients are further encouraged to maintain their own medication records to compare with care providers' records.
Better Quality of Care
New research showed that nursing homes that adopted new information technologies reported better quality of care. Researchers from the University of Missouri showed that the more sophisticated a nursing home's technology, the better the quality of care.
"We already knew that information technology can help create better care outcomes, but this study helped us see which technologies improve which elements of care," said Gregory Alexander, interim associate dean of research at the university's Sinclair School of Nursing.
Lower Rates of Infection
Health information technology also showed promise in senior settings.
"As IT capabilities and extent of IT use improved in nursing homes, we saw an associated decline in urinary tract infections, among other correlations," Alexander said.
Alexander and colleagues also found that nursing homes that adopted technologies saw notable reductions in urinary tract infections, as well as fewer patients who reported new or worsened pressure ulcers. There were also fewer patients reporting moderate to severe pain.
Better Accountability
As nursing homes are frequently hit with complaints of abuse and neglect, cameras and recording devices can also offer security as well as a note of assurance.
Though nursing homes and LTC facilities can be unwilling or slow to adopt new ideas, technology may hold the answer for the aging population. Nursing home costs, which have increased from $18 billion to almost $100 billion between 1980 and 2002, will continue to rise. Adopting health information technology will enhance the quality of care, facilitate coordination and boost efficiency in long-term care, according to the LTC Health Information Technology Summit.
Though technological advances may be costly upfront and take time and energy to implement, it will inevitably help save costs in the long-run while boosting efficiency and productivity.


text:
Forever were commissioned by the UK's leading Pressure Cooker brand to create the customer journey, undertake a UI/UX redesign and develop more interactive elements to maximise engagement opportunity and build an online community through social media. The post Forever has been appointed to create the official app for Drew & Cole. appeared first on Forever Agency.
Source Feed: Forever Agency
Source Feed: Forever Agency
Categories: uncategorised


text:
Thank you all for your support in 2019 at our fun-raisers. Our BIG annual event is coming up! Please join Kevin Jeffries and the 2020 campaign for the annual Lake Elsinore Storm Opening Day campaign reception on Thursday April 9th in the Lake Elsinore Storm Stadium Diamond Club (use the left field gate access). Reception starts at 5:30pm, with first pitch at 7pm. This is a great outdoor event overlooking the entire field from above the 3rd base line. You will enjoy great company, an exciting ballgame, and traditional ball park food & drinks. The game and the reception has sold out in the past so get your campaign reception tickets early and register today.
More information will be posted here and at:www.michaelwilliamscompany.org. Or call: 951-686-1996.


text:
Arizona State scored a run in the top of the first inning and rode the arm of freshman Breanna Macha the rest of the way en route to a 1-0 upset over fifth-seeded host LSU in the winners' bracket of the Baton Rouge Regional on Saturday.
Macha struck out six Tigers and walked just one while scattering four hits, and ASU (36-20) advanced to the regional championship on Sunday at 10 a.m. The Sun Devils will face LSU, who defeated Nebraska Saturday night, again for the opportunity to advance to next weekend's super regional with a victory.
Related: ASU softball opens NCAA regionals with win over Nebraska
Macha (18-11), who pitched at Mesa Red Mountain High, shut down the nation's 16th-best hitting team – an LSU team (45-12) that entered the game batting .345 and averaging just under seven runs per game on the season – and held the Tigers off the scoreboard for just the second time this season.
Twice Macha stranded runners on third base and held the potent 3-4-5 hitters in the LSU lineup to 0 for 9 on the day – a trio that features Bianka Bell (.465 average, 17 home runs on the year), Sahvanna Jaquish (.327, 17 HR) and Kellsi Kloss (.351, 12 HR).
More: ASU softball seeking postseason redemption
Macha struck out six LSU batters in a lineup that was averaging under four strikeouts per game and at one point retired 14 batters in a row.
Photos: Arizonans in 2015 NCAA softball tournament


text:
We look at twenty of the MCU movies that make up the Marvel Cinematic Universe, ranked from worst to best, with 'Avengers: Infinity War' in the middle.
We're here to spotlight inconsistencies in the MCU movies: Marvel movie plot holes fit to order to infuriate any MCU fanboy / girl.
Donald Glover has been one of the most interesting performers on screen. Here's our ranking of Glover's roles that prove he's always been dynamite.
Will Marvel just keep churning out movies for the rest of time? So what movies could they possibly have planned up until 2025? We have a few ideas.
Last year epic superhero flick 'Avengers: Infinity War' came out. Here's why the film itself has left little to be desired for the MCU fandom.
The Spider-Man franchise keeps going. Here are the Spider-Man movies ranked from "surprisingly entertaining" to "They spent how much money on this dreck?".
Almost any classic Hollywood movie follows the Hero's Journey: a 12-step monomyth concept from Joseph Campbell's 1949 book 'The Hero with a Thousand Faces'.
We've got a quirky knowledge-filled guide for you about some of the Audi's most notable appearances in movies over the last number of years.
To celebrate its theatrical release, we're ranking all the superheroes featured in possibly the last Avengers movie, 'Avengers: Infinity War'.


text:
4 ways operators are serving pizza
With a seemingly endless array of toppings, pizza can be menued as an indulgent comfort food or as an option that encourages healthier eating. Here are four ways pizza has been popping up on menus of late.
1. Full serving of veggies
At Francis Scott Key High School in Union Bridge, Md., nutrition staff use pizza to help students get their daily serving of vegetables. In honor of National Nutrition Month, staff partnered with a local hospital to create a flatbread pizza with roasted broccoli, red bell peppers, onions and cauliflower that was served to students for free one day during lunch.
2. Pizza your way
Consumers visiting The Grove Cafe inside Clovis Community Medical Center in Clovis, Calif., can choose from rotating options such as a bacon, mushroom and roasted pepper pizza or build their own personal pizza using toppings including onions, pineapple and Canadian bacon.
3. Student-created toppings
Lewiston High School in Lewiston, Maine, has begun offering a pizza topped with chicken and scratch-made pesto created by students using produce from the school's garden. The pesto includes spinach, mustard greens, olive oil, lemon juice, Parmesan cheese and garlic.
4. Pizza with a kick
Students at Appalachian State University in Boone, N.C., can grab a variety of freshly prepared specialty pizzas at the pizza concept inside its main dining hall. Its hot wing pizza features a hot sauce base with marinated chicken, cheese and a ranch dressing drizzle.


text:
We like challenges. We believe that the right security solution could be a game changer in the way enterprises work and address threats in the future. We believe our solution will forever transform the security space.
We are looking for smart people who collaborate, innovate and make great security products.
The right candidates fit this profile:
Positive analytical problem-solving mindset.
Ability to work and learn in a fast-paced, demanding, dynamic environment.
Excellent organization skills and attention to detail.
Excellent communication skills.
Willingness to both collaborate and work independently in a friendly respectful professional environment.


text:
Travel Updates Related to COVID-19
- Alerts.
Safety, Innovation, Mobility, Attract, Retain & Train
State Materials Office
Office ManagerTimothy J. Ruelke P.E.Director, Office of Materials
5007 N.E. 39th AvenueGainesville, FL 32609
Tel: 352-955-6600Fax: 352-955-6644E-Mail Us
Additional Contacts Staff Directory
The Florida Department of Transportation's Materials Program ensures that the materials used in transportation construction projects meet the required department specifications. In addition, the program investigates new and emerging technologies to improve the long-term performance of transportation facilities. Learn More
The Materials Program Survey is here and will be open from February 18, 2020 to May 15, 2020. To ensure the Program's success, critical objectives are surveyed. Please take the opportunity to participate and provide your feedback.
Take the Survey Here
CMEC LABORATORY QUALIFICATION PROGRAMPosted: March 23, 2020Materials
Bulletin 20-10
TEST METHOD FOR AIR CONTENT OF FRESHLY MIXED CONCRETE BY THE VOLUMETRIC METHODPosted: March 23, 2020Materials
Bulletin 20-09
NON-METALLIC REBAR FASTENER USE IN PRECAST CONCRETE DRAINAGE STRUCTURES AND BOX CULVERTS AND INCIDENTAL PRECAST CONCRETE PRODUCTSPosted: March 18, 2020Materials
Bulletin 20-08
Cemex - Miami FL (CMT24)Posted: February 21, 2020Materials
Bulletin 20-07
AGGREGATE FOR CONCRETE PRODUCTS ONLYPosted: February 21, 2020Materials Bulletin 20-06
Argos– Tampa, FL (SLAG01)Posted: February 18, 2020Materials
Bulletin 20-05
Argos Cement Plant– Newberry, FL (CMT09)Posted: February 18, 2020Materials
Bulletin 20-04
Florida Department of Transportation
Safety, Innovation, Mobility, Attract, Retain & Train


text:
Blog post
On Saturday we had a handbell day in Tulloch, hosted by Peter Bevis and Helen McGregor. Nick Jones organised the ringing programme, and beforehand he and I had discussed the best 12-bell method to try as a step beyond Kent. As a result, when he sent out the schedule,...Read more
Saturday 4th October saw one of our biggest handbell days, with a total of 19 ringers attending. Handbell ringers came from Aberdeen, Dundee, Dunblane, Haddington, and Edinburgh. There was even a representative from our unoffical Southern Branch in Penrith. This may be our broadest geographical spread, and in itself shows...Read more
Yesterday was the Scottish Handbell Day, a high point in the calendar at 1 Albany Quadrant. It was the best one yet, and everyone went away happy. We had 18 people, and by lowering our sights a little instead of forcing everyone to ring on 12, we...Read more
After successfully sending our Handbell Club students away happy with their accomplishments, we turned to the more challenging part of the day, which consisted of satisfying various Surprise Major requests, and filling in the rest of the bands appropriately around them. We had a small number of attenders, but a...Read more
Wednesdays are the day that I run the Handbell Club over the lunch period, and after our success with the students at the Scottish Handbell Day, I was thinking about ways to keep that momentum. I was also thinking about how to catch the other pupils up.
The bad news...Read more
Our fifth Scottish Handbell Day was a day a two parts, and the first part was dedicated to the Mount Vernon Handbell Club. We invited pupils to come for one session and have a 'masterclass' with experienced handbell ringers. About half the club was able to come, and we arranged...Read more
Handbells, and why more people don't ring them, has been a subject on the Change Ringers mailing list over the last couple of days. The debate has been fairly lively, not yet very conclusive, and so probably far from over.
In the midst of this, Lester Yeo, from the Guild...Read more
Saturday was the Fourth Scottish Handbell Day. It went well. We scored a total of six quarter peals, including a first (the traditional Plain Bob Minor), a first of Surprise Major (the traditional Yorkshire), a first on ten (Kent Royal) and two firsts of Surprise Royal (Yorkshire. Is that traditional?...Read more
Last night was our last opportunity to have a practice with Josy before her official quarter peal attempt on the Handbell Day (Josy is our new-ish learner: since about March). We have been practising long touches of Plain Bob to work her stamina up for a quarter, and we decided...Read more


text:
SSI Food Service Inc. - Executive Summary
SSI Foods Service Inc. is committed to protect the health and safety for all on site personnel, visitors, the environment, and local community. To ensure the safe operation of our process, SSI has complied witrh OSHA's Process Safety Management (PSM) Title 29 Code of Federal Regulation(CFR) 1910.119, EPA's Risk Management Program regulations (RMP) Title 40 CFR Part 68, and ANSI/IIAR 2-1992 Standard for Equipment, Design, and Installation of Ammonia Mechanical Refrigeration Systems.
To deal with the risks involved with ammonea refrigeration, programs have been developed to prevent the occurence of a release and or minimize the consequences of a significant release of anhydrous ammonia, fires, explosions, and other types of catastrophic accidents. Programs developed for the PSM/RM plan include employee participation, process safety information, process hazard analysis, pre-startup safety review, standard operating procedures, training, management of change, mechanical integrity, hot w
ork permit, contractor qualifications, and incident investigation. To help coordinate the plan, a management program has been established as well as an internal audit program which will help identity compliance status and possible deficiencies in the program. In the event of a toxic release , an emergency responce plan coordinated with the locan emergency planning commission (LEPC), rural fiire department and trained company personnel has been written. Annuall drills are held to ensure that all emergency responding agencies are familure with the plan and their responsibilities. The ultimate goal for SSI's PSM/RM plan is to prevent accidental fatalities, injuries, illness and avoid physical damage to the environment. These programs enable our facility to operate a refrigeration system safely because they focus on the rules, procedures, and guidelines which govern the industry.
SSI Foods Service Inc. processes fresh meat products and uses a refrigeration system for freeze tunnels,
storage and plant cooling. The maximum inventory of ammonia onsite is 60,000 (lbs). RM regulations require hazard assessments, including offsite consequence analysis. EPA categorizes release scenarios as worst case (WCS) or alternate case (ACS). To evaluate potential WCS's and ACS's for toxic chemicals, the distance to endpoint is determined. The toxic endpoint for ammonia is 0.14 mg/L (200 ppm). Following EPA guidance the largest vessel/release rate was used to estimate the WCS. All of the major ammonia vessels are located indoors and many would have significant passive mitigation factors. The highest 10-minute release rate was determined to be from the high perssure receiver which contains 12,000 (lbs) of ammonia liquefied under pressure. While the high pressure receiver is located inside a building, it is also adjacent to a door; therefore, the building mitigation calculations in EPA's Risk Management Program Guidance for Ammonia Refrigeration were not used. Instead the m
ore conservative and more suitable passive mitigation factor provided in RMP*Comp was used to calculate the mitigated release rate. The WCS release quantity is 12,000 (lbs) at a rate of 660 (lbs/min) for a distance endpoint of 1.5 miles before dispersing enoughto no longer pose a hazard to the public. The following public and environmental receptor locations are within the WCS toxic endpoint radius: Wilder Head Start School, Holmes Elementary School, Wilder Junior, Senior High School, Industrial and Commercial establishments (including commercial agriculture), with a estimated population of 1,426, and Hwy 95. This scenario is unlikely to happen for the following reasons; worst case weather conditions are uncommon; the vessel is located in a building that would help control the release; industry standards for the manufacture and quality control of process vessels; ammonia is not corrosive; the accident prevention program including mechanical integrity, inspection and testing for e
quipment, and replacement of equipment if necessary; installed ammonia area sensors to warn operating personnel of process upsets; and the emergency response plan and equipment in place at the facility. To select a plausible ACS, SSI considered three scenarios, the one selected for the RMP Submit was the recharging of the ammonia system. A break or rupture of the 1-inch recharging hose that occures during the system recharge, resulting in a vapor phase release. Recharging is performed by loading vapor phase ammonia from pony tanks. The pony tanks are placed just outside of the south entrance door to the machine room while recharging. The release is assumed to happen under worst case summer conditions (190 psig and 105 degrees fahrenheit). The temperature in the tank will drop due to the ammonia evaporation (latent heat) ; however, to be conservative this effect has not been considered. It is assumed that this release can be controlled within 10 minutes. The vapor release rate c
alculated is 127 (lbs/min) for 10 minutes for a quantity of 1,270 (lbbs) at a distance of 0.3 miles to toxic endpoint. The following public and envirnmental receptor locations are within the ACS endpoint radous: Four (4) residences, with a total estimated population of 12, Commercial Agriculture and Hwy 95. This scenario is unlikely for the following reasons; the accident prevention program inplace at the facitity including operationg procedures to have personnel present at all times during the transfer process; the mechanical integrity program for regular maintenance, inspection and testing, and replacement of equipment if necessary; and the emergency response plan and equipment in place at the facility.
The accidental release prevention program in general starts with good operating and manufacturing practices. All ammonia process equipment, piping and valves are inspected on a regular schedual depending on manufacture and industry recommendations, for example; all compress
ors are inspected on a monthly basis for oil leaks, pressure and temperature guage calibrations, vibration analysis, oil pressure, and amp reading for motors; alignment of compressor motor and compressor, filter change, vibrating readings and sensor calibrations are performed every 6 months; the condensor 24 point air purger system is inspected weekly, this includes checking and cleaning nozzles and strainers, motors are greased, fans are checked for cracks, and piping is inspected for leaks; low and intermediate pressure reciever oil pots are drained, pump pressure is recorded and pumps and valves are defrosted for excessive ice build up weekly; visual inspection for equipment and vessel operating limit conditions, piping and valves are assessed for leaks, integrity, material deformity daily; pressure relief valves are replaced on a five year preventative maintenance schedual or when one has been activated. Area ammonia sensors are installed in the compressor room as well as a
seperate detection system strategicly located throughout the facility.
The facility's emergency response plan is based on OSHA requirements for Emergency Action Plan (29 CFR 1910.38 and 1910.119) and Hazwoper (29 CFR 1910.120). Onsite personnel have been trained and are quilified to respond aggressively to isolate and control a release. Equipment such as self contained breathing apparatus, respirators, serivex body suits, encapsolated level A suits, gloves, boots and personal monitors are available for the emergency response team (ERT).
During the past five years there have been two releases. On August 31, 1996 a strainer valve was opened instead of a service valve. The strainer valve had not been plugged from a previous service resulting in a release. There were no injuries on or offsite the facility. Evacuations included only facility personnel and the approximate release quantity was less that 200 (lbs) ammonia. The second release occured on April 5, 1999 when a valve
was opened on a existing pipe that had not been capped. Evacuations included only facility personnel and the approximate release quantity was 192 (lbs) ammonia. The local rural fire department was dispached but were cancelled enroute prior to arrival. There were no offsite injuries but one contract security personnel on site reported some respiratory discomfort and requested a medical observation. The security employeel was seen by a local physician and released. On both inccidents, the National Response Center was notified and incident investigations were conducted. On the 1999 incident a report was sent to the Local Emergency Planning Commission (LEPC) and State Emergency Response Commission (SERC). Corrective actions included retraining process operators, valves tagged and locked out, and a plan to remove and cap the existing line from the system.
Continued improvements for the ammonia refrigeration process is a top priority for SSI Foods Service Inc. The management plan a
s well as our prevention programs will be monitored and updated as neccessary to ensure that all elements for the PSM/RM plan is complete.