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It Is All About BTC, LTC, ETH, ZEC mining as well as other alternative crypto currencies
It has been a while since we have last talked about PegNet (PEG) CPU mining at the Orax Pool, so we have decided to check if there is any development lately. Well, there is apparently a new miner since the last time we have tried that increases performance significantly and it is well worth updating your mining software if you are using older one. Three or so months ago when we tested performance at the Orax Pool an Intel Core i7 6850K (6C-12T) processor was giving a hashrate of around 65000 H/s LXRHash algorithm (using version 1.0.10 of the miner). Now, the latest version 1.1.0 of the mining software results in almost double the performance of the older version with about 110 KH/s. And if you happen to have an AMD Ryzen 9 3900X (12C-24T) processor you could be getting up to about 140 KH/s with the latest miner.
Unlike with RandomX for instance where the latest AMD Ryzen processors have some advantage over Intel CPUs, here with the LXRHash algorithm used by PegNet (PEG) it seems that Intel does have some performance advantage. Of course the newer and faster Ryzen 3900X with its 12 cores and 24 threads does manage to outperform a 6 core and 12 threads Intel, but not by that much. So if you have a latest generation Ryzen processor you might be better off mining some other CPU coin. Recently we have tried even the fastest AMD Ryzen Threadripper 3990X with the PegNet (PEG) mining on the Orax Pool with the latest miner and it did manage to provide us with around 350 KH/s of hashrate for the LXRHash algorithm. The problem with the Threadripper 3990X is that he miner could not use more than 64 threads and while the processor does have 64 physical cores it has a total of 128 logical cores, so the miner could not fully utilize the available hardware, otherwise the actual performance should be higher.
– To check out the Orax Pool for mining PegNet (PEG) with your spare CPU processing power…
We have already covered how to mine PEG on the ORAX Pool, but it is not the only pool available for PegNet (PEG) mining. Prosper Pool is the other public PegNet mining pool that you can point your free CPU resources to get some PEG, it is smaller than ORAX and you need to ask for an invitation code on their Discord first in order to finish your registration. The Prosper Pool has a very simple text-based back-end with some basic functionality, and although all of the important info is there, unfortunately there are some features missing like no option to change your payment address for instance or set a minimum payment threshold. Another important thing to note with this pool is that the payments are on once a week, so maybe more suitable for people with less computing power.
You need to start by downloading the prosper-miner pool client for Windows (64-bit only) that we are going to be using here, there are also versions for Darwin, FreeBSD and Linux as well. The first time you run the miner you will complete the registration on the pool and you need to provide the invite code you need to request first and also initial generation of 1GB map of the LXR hash (PegNet hashing function) will happen. Below is an example of the command line for the first run, the miner will ask for a password, just make sure you run the prosper-miner executable from command line console, do not try to run the executable file directly by double clicking it under Windows:
prosper-miner.exe -s controlpanel.prosperpool.io:1234 -u YOUR_EMAIL_ADDRESS -p -a YOUR_WALLET_ADDRSS_HERE -i YOUR_INVITE_CODE_HERE -m MINER_ID
The next time and if/when you run the miner (including on different system) you don't need to provide the password or the invite code anymore, you will have a registration on the pool, so you only need the username – the email address you have used for the registration:
prosper-miner.exe -s controlpanel.prosperpool.io:1234 -u YOUR_EMAIL_ADDRESS -a YOUR_WALLET_ADDRSS_HERE -i -m MINER_ID
The MINER_ID is where you type different identificators for different mining rigs, so that you will know which one is active and which one isn't mining, though apparently that functionality is still not fully functional on the backend.
The easiest way to obtain a wallet address is to use one of the exchanges that support PEG trading – Citex, VineX or ViteX DEX which should be fine as long as you will be mining and trading only, for holding PEG tokens it would be better if you go for local wallet.
– To learn more about the PegNet project and the PEG tokens it uses and you can mine…
PegNet is a decentralized, non-custodial network of tokens pegged (stabilized) to different currencies and assets that allows for trading and conversion of value without the need for counterparties. It is a fully auditable, open source stable coin network using the competition of PoW and external oracles to converge on the prices of currencies and assets. You can mine PEG, the token of PegNet which can be seamlessly converted to any pAsset on the network with no spread, no slippage, and with infinite liquidity. The PEG mining is CPU-based thanks to its unique LXRHash algorithm and you can either solo mine or use a pool with the second option being more interesting and easier for most users with limited hashpower due to the way rewards are being distributed. PegNet was launched fairly with no premine and no ICO.
The miners in the PegNet network act as oracles for the pricing data of the PegNet assets. Miners are responsible for fetching the latest pricing data, and reporting the prices to the Factom Blockchain. Their prices will be submitted in a specific oracle chain on the Factom Blockchain. After each block is published, all of the entries within it will be analyzed by the miners and the reward will go to the miners that have given the most authoritative answers. Each entry that is published as part of the mining process must contain the Oracle Price Record (OPR). This allows the miners to give the PegNet network real-time price information. The OPR includes the full list of the PegNet assets as well as their current price in PEG. The hashing algorithm employed by PegNet is designed to be RAM access bound. CPU or GPU hardware has less of an impact on the overall performance of the hashing challenge. The PegNet provides a static 5000 PEG reward with every block with 10 minute block time with the reward distributed evenly among the top 25 graded OPRs (200 PEG each).
The only available pool at the moment for PegNet PEG mining is ORAX Pool that combines all the hashing power of many users in order to get more winning OPRs and then splits the award among all of the miners using it. Since every round the number of OPRs from the pool can vary the total block reward distributed among miners will be variable as well and in rare cases it can even be zero (no winning OPRs and no rewards). Going for solo mining PEG with little hashing power will make it harder for you to get among the winning OPRs, though if you do it would mean that you will get 200 PEG as a reward. So our guide here is for pool mining on the ORAX pool and not for solo mining.
To start mining on the ORAX pool you need to first download their client application orax-cli as it is being used both for registration on the pool as well as for mining. You need to run
"orax-cli.exe register" on the system you are going to be using for mining and the first time you do so to select to create a new account, when running on the second and so on mining rig you can just select to use existing account and login with it. When registering you need to provide email address (login ID) and password for the pool as well as payment address, each mining rig will get a unique ID generated and you can set an alias to know which miner is which in the pool stats. The easiest way to obtain a wallet address is to use one of the exchanges that support PEG trading – VineX or ViteX DEX which should be fine as long as you will be mining and trading only, for holding PEG tokens it would be better if you go for local wallet. The third and newest addition is the Citex crypto exchange that has just announced it is also listing PEG for trading…
To start the actual mining process you need to run
"orax-cli.exe mine". Have in mind that the first time you run the mining command it will take some time before the actual mining process starts, something like 10 or more minutes for the initial generation of 1GB map of the LXR hash (PegNet hashing function) and then run 1 minute test of the hashrate that your hardware is going to be capable of delivering, the hashrate estimate will then be reported by the miner. This is needed only the first time you run the miner on the mining rig, the next time it will start mining immediately, though no hashrate will be reported during the mining process. You can track hashrate and reward stats on the pool every 10 minutes after a block is finished and data is reported poolside.
By default the miner uses all of the available logical cores, though you cans elect the number of threads to use. Although the CPU load may be 100% when mining the actual power usage and operating temperature will most likely be lower compared to other CPU minable coins due to the specifics of the algorithm being used by PegNet. The LXRHash uses an XOR/Shift random number generator coupled with a lookup table of randomized sets of bytes. Using a 1GB lookup table results in a RAM Hash PoW algorithm that spends over 90% of its execution time waiting on memory (RAM) than it does computing the hash. Of course performance wise the CPU affects hashrate and it seems that unlike RandomX for instance where AMD Ryzen is doing quite well compared to Intel CPUs, here LXRHash does manage to provide some advantage for Intel processors. AMD Ryzen 5 3600 (6C-12T) processor manages to deliver around 45000 H/s while an Intel Core i7 6850K (6C-12T) processor gets you around 65000 H/s for mining PEG using the LXRHash algorithm.


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"We were made for each other, right?"
She stops humming and looks around at the question. I feel her eyes searching mine, but I just keep looking up at the stars, at the moon, on my back with my neck resting on my sleeping roll.
Before us, the valley holds its breath and the peaks loom. They loom tall. Gingersnap's camera clicks on its timer, marking another hour we've spent here in the cradle of the mountains, under Selene's sky.
"You know we were made for each other, Silver," she says. "Have you ever doubted it?"
"No," I say truthfully. "Have you?"
"No. Not once I realised I loved you."
"'Love'." I whisper it under my breath. "Does love last forever?"
Snaps walks over to me and looks down at me, forcing me to meet her eyes. "What kind of question is that?"
"I've been thinking about 'forever', lately. I don't know if we're really here forever, and I don't really trust Celestia to be honest about it. But even if it's just… close to forever, does love last that long? Can ponies really be together forever? Even ones who were made for each other?"
My soulmate sits down beside me and looks up at the sky, too, humming a little. "I guess for you 'forever' is still a novelty. I've never thought about it very hard. But…" she pauses, looking down at me once more. "Yes. I think ponies who were made for each other can stay together forever."
"What if we break each other's hearts?" The words rush out of me before I really know what I'm saying. It's not uncommon for me. I blink and sigh a little at myself.
But Gingersnap almost giggles. "Are you planning on breaking my heart?"
"No! I just… I don't know. Forever is a long time. Forever. Isn't it likely to happen eventually? Celestia couldn't stop something like that without messing with our minds. And I don't want her to, still."
"I don't think it's likely at all," Snaps counters. "That's like saying that over a long enough time period you're bound to be struck by lightning. If you never go out in a storm, though, it just… isn't true."
I mull over this. "I see what you mean."
We continue to observe the night. It is definitely beautiful. The mountains give it a sense of… reality. Somehow, it's not just a backdrop. The mountaintops really do look like they're almost touching the sky.
When Gingersnap finishes with the photos her camera is taking every hour, the result will be a single image showing the moon moving across the sky, across the mountain range.
I can't wait to see it.
"Is this something you really worry about?" She asks it casually, but I know her well enough to sense that it's an important question.
I think before answering. "Sometimes it is, yeah. I feel like the luckiest pony in the world to have met you. The idea of what we have going away is… awful. And I worry about 'forever'." I add in a mumble, "Never had to worry about decades before Equestria, let alone forever."
"Silver, I love you. I won't break your heart, and I believe that you won't break mine. We face eternity together. Okay?"
Her words ignite that feeling in my chest, that feeling of pure love that makes me want to laugh and cry and melt. It only intensifies when her wing gently caresses the back of my head, and I roll over and pull myself into a sitting position.
We sit there side by side, leaning into each other, my hoof on hers and her wing on my back, silently looking at the mysterious peaks, so distant and yet so strangely close.
We sit there until the camera clicks again. Then I yawn.
"You sure you don't care if I sleep a little?" I ask.
She gives me an amused smile. "I'm sure."
"Mmkay. Only for a 'lil bit. All that magic earlier really took it out of me." I roll out my bedroll and get comfortable.
Gingersnap's gentle humming is all I hear as I drift off to sleep.
I try to open the door up to the office, but it's locked. But… my magic is the key. It shouldn't be locked. I try again, but it doesn't budge.
I rattle the handle, and it has no effect.
I look around the studio. It's dark. The lights are off. What was I… doing here? I'd have to go through the pub apartment to get upstairs.
I leave the studio, setting off the little bell as always, and before I know it I'm walking into the Silver Sword. Past the few patrons and through the door my magic does open, up the stairs to find myself in our sitting room.
Something is wrong.
I'm filled with dread because
The door is gone
There's no way into the office that was Snaps' apartment
And I just know without calling out that she isn't here, this place is empty and it's just me
I can't smell her at all
This is wrong—
I'm rushing down the stairs, out of the pub, into the street. I run past the park, up to the studio once more, and enter with that same jingle.
The door still won't open for me. I pick up a hoof to knock—
And she's there, opening the door, regarding me cooly. Gingersnap, the pony I love. But that same dread is there, that same knowledge that something is off—
"Silver Star. This is my place. Don't try to get in."
I'm just filled with confusion. Isn't it ours? "Snaps, I… where did the portal door go? Why is—"
"Gone," she says with a shake of the head. "I decided I can't handle… this. I need my own space. Living with you is too hard."
I can't even respond. The dread that gripped me before has morphed from a sort of anxiety to something far worse. I almost can't breathe. I'm being crushed.
"I still want to be friends," she continues. "I love you as a friend. But that's all. I need to have my own place to live," she repeats, "and I can't share it with you. I'm sorry."
The feeling intensifies; it blooms into something torturous
I'm being torn
disembowelled and crushed—
Then she smiles at me. For a fraction of a moment it's like nothing has changed but
"You're still my favourite pony. I love you, Silver. Just not like before. Not like you thought."
She's smiling, and stepping forward for a hug, and I want to embrace her and touch her and love her and say it's fine and I'll be the best friend she wants but it hurts,
it HURTS
And as we touch, Gingersnap dissolves. Evaporates. I blink, and she's gone, and it's just the door, there, tauntingly open so the warm light from the apartment above casts a twisted, inviting glow onto the stairwell—
"Be at ease, Silver Star," a voice says behind me. "This is but a dream, and I am here."
As I turn around, a hoof falls on my shoulder and instantly I know everything I need to. I'm sleeping. This was a nightmare. That wasn't Gingersnap. Selene is here. And indeed, as I blink again the dark studio dissolves as well and I find myself face to face with the Princess of the Night, who gives a little smile.
The horrible feeling, the pain, melts away to be replaced with a torrent of relief. At least, most of it does. There is still a pit of anxiety, there deep in my chest, but now that I'm safe from the apparition it's supremely easy to ignore. "Thank you, Princess," I say with what's almost a voice crack. "Thank you."
"You are very, very welcome." Selene takes her hoof from my shoulder and her horn glows. The formless black void around us materialises into a night sky, and a valley, and mountains on all sides. I see my sleeping form, there on the grass, deceptively peaceful. Gingersnap is sitting upright, but pressed close into my body as I sleep all the same.
I smile, and feel like crying.
"You know this was truly naught but a fantasy, don't you?" Selene looks down at me, kindly but searchingly.
"I… of course. I know that. We're soulmates."
Selene nods and looks at us, me sleeping gormlessly and Gingersnap staring up at the sky beside me. "I can see that."
"We're here for your sky," I say, swallowing and feeling a little stupid. "It's… so different to the sky back on Earth. Here, I feel like we could stare into it forever and keep seeing new little details. It's… beautiful."
"Well, thank you, Silver," Selene says with a twinkle in her eye. "I can't pretend to be fully responsible, but… your reverence is noted all the same." She nods at the mountaintops. "You've chosen a wonderful spot."
"Gingersnap did."
"Princess, do you ever worry about eternity?"
She looks back at me. There's a long pause before she speaks. "No. I do not." I open my mouth, but she continues. "I have lived a long time, Silver Star, though it may be only an infinitesimal fraction of what lies before us all. In all this time I have learned that change may surprise you, and might even cause you strife, but—" here she nods to the pair of us, there in the valley, "the things that matter endure. Love endures. Time cannot take it away from you, and ponies who form that bond, that 'mating of souls' as you put it, will never break each other's hearts. This, I truly believe."
There's silence as I take this in. "I've never been scared of change," I say. "I just can't believe that I get to have this life forever. It's too good to be true."
Selene gives a small laugh. "That's a very human expression. Here in Equestria, nothing is too good to be true."
I sigh and blink as I take in Gingersnap sitting there beside me, and this time it's almost a happy sigh. "Thank you, Princess. I'm okay now."
"Indeed," Selene says with a smile. "Then I will leave you, now."
"Can you wake me up?" I say it quickly.
"Of course," Selene says with a wink.
Then, as the princess' horn glows and she disappears in a flash, it all dissolves once again.
"Hey, Snaps?"
I feel her start a little and look down at me, surprised that I'm awake. "Yeah?"
"You like living with me, right?"
This time she does laugh. "'Course I do. It's just like living on my own, except you cook sometimes and I get to cuddle you. What's not to like?"
I put out a foreleg and drag her to the ground beside me. She gives an amused hum and rolls into me, curling up a little so I can wrap my legs around her.
"You promise?"
She snorts. "Yeah, Silver, I promise. What brought this on?"
"Just a dream. I'm still a little scared about forever." When I say it, I know, I know that Snaps is rolling her eyes. I can sense it. "Or, I was. I think I'm over it now."
"Just like that, eh."
"Oh, shut up."
She giggles again. "Don't take that tone." Snaps rolls over, then, to face me with a tiny grin. "Are you gonna tell me what the dream was about?"
"You didn't wanna live with me any more. It broke my heart."
"Is your heart that fragile?"
I snort. "All hearts are fragile."
"Sorry," she says quickly, "I didn't think before I said that."
"It's fine; I know what you meant. But yeah. You could shatter my heart with a feather, if it were one of your feathers."
"Well I won't." She puts a hoof on my cheek and holds it there, looking into my eyes. "I won't. Do you understand? I promise. I promise forever." She pulls herself closer to me and closes her eyes, pressing her muzzle into my shoulder. "Forever," she murmurs again.
My heart fills with so much love I almost moan. I definitely shed a few tears, and take a deep, juddering breath in. Her scent fills me and banishes the last shred of anxiety within me. All I can feel is love, love for this mare whom I was created to satisfy, filling me to the ends of my limbs and making my heart resonate with the sound of her voice in my head.
The camera clicks another frame. We pay it no mind. We just breathe, there, together in the shadow of the enchanted mountains. The horizons are beginning to betray the first signs of twilight, and we somehow move even closer in together as the mists begin to gather there in the valley.
That's where the light finds us, hours later, as we simply continue to hold each other and the sun rises on another day of eternity.
"You're still my favourite pony. I love you, Silver. Just not like before. Not like you thought."
She's smiling, and stepping forward for a hug, and I want to embrace her and touch her and love her and say it's fine and I'll be the best friend she wants but it hurts,
This is gut-wrenching. My heart actually skipped a beat when I read this.
This is, as usual, a beautiful little snippet. You use the Optimalverse so effectively to explore the "human" condition. Thank you for sharing this.
Very different feel to the prequels. I especially liked the line about "one of your feathers."
A beautiful relationship need not wane in the shard. But if those two must separate one day, I'm sure they will be as happy with each other at its end as they were throughout it.
As always, a good story, Syke.
Gorgeous stuff. And yeah, this is an entirely reasonable fear when you're staring down the closest thing this universe has to eternity. It's a long time, and a lot can happen. But when you have a GAI looking out for you... Well, it'll probably turn out alright.
Thank you for this.
This has been a nice series (so far?).
I disproportionately appreciate that you refused to compromise their asexuality through it all and, implicitly, into the unknowable vastness of the future.
I very much like this series and hope it continues, as it adds a nice spin on the FiO series. I can't recall reading many stories with fairly modern tech in Equestria, as well as the POV of one of CelestAI's created ponies.
As for this specific story itself, it certainly has some beautiful moments. For a created pony who's been designed so for them an uploaded human is their perfect mate, and having never had to worry about mortality, an eternal relationship clearly isn't something to worry about. For a former human with an expectancy of decades, and not having been pre-programmed not to be tired with a partner, then it's definitely a long-term worry.

subset: commoncrawl


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USB Cold Cathode?
Hi, I have been wondering about creating an ambient glow around the back of my iMac with a usb powered cold cathode light or led strip, could anyone help me with this? i would prefer a prefab solution that doesn't involve much soldering or modification of hardware but that stuff is not necessarily beyond my skill level. (and sorry if this is in the wrong place, its my first post :P )
Topic by awesomesquared | last reply


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The Natural Tent Company - Stellar Service and Tents that Reach for the Stars
I was engaged, betrothed, a fiancée… I was to be married! And yet the euphoria and excitement were soon joined at the party of anticipation by the rather drabber company of both pragmatism and common sense. So, in a romantic yet practical frame of mind, I began to undertake research into wedding venues.
Not only did I fail to identify a single venue that quite conformed to my vision of nuptial celebration, but they were all so fiendishly expensive; with basic hire rates quickly and exponentially supplemented by baffling tiers of hospitality and entertainment. Desperate for a little more direct control, I casually asked my parents if we might put a tent on their front lawn (a mere stone's throw from the church at which the matrimonial deed was to be done) and hold a party within it.
Not hearing any immediate objection, I diverted my research efforts towards pole and canvas. I quickly hit on the idea of tipis, and had no trouble convincing the husband-to-be that they would prove infinitely superior to a conventional marquee. Having seen them at various festivals, I was familiar with their elegant shape and atmospheric interiors. The structures are styled on traditional Lavvu, moveable dwellings originally designed to enable the Sami people, indigenous to northern Scandinavia, to follow their reindeer herds across the treeless plains.
I set about sending a flurry of emails to all the tipi companies that Google would spit out at me; and most replied, but largely with generic responses that lacked a great deal in the way of clear information. The majority were hugely expensive; and all but one company had copious lists of add-on costs; "Oh, you'd like your guests to be able to sit down… well that will be another £***. You'd like flooring AND lighting… well add £*** to your bill", and on and on it went. My patience was starting to wear thin amidst this mire of spiraling costs and ludicrously inane communications.
The Natural Tent Company website stood out as colourful and attractive; and I wrote off to the company with (relatively) high hopes. I received a clear and friendly response from co-owner Paul within 12 minutes, with an all-inclusive quotation attached along with all the information I could possibly need. Within half an hour of my initial query we had arranged a site visit and plans were underway; and this level of sharp service didn't wane at any stage. Paul's colleague and co-owner Matt carried out the site visit; remaining consistently positive and upbeat despite various challenges presented by the site; a positivity which (it should be said) he managed to maintain throughout all our dealings with the company.
Paul and Matt founded The Natural Tent Company in 2014. Matt has a background in tipi building and years of working in the planning and catering industries. Paul has been involved in IT and the media for years. They were both looking for a new challenge and set up the company together. At every stage, I received additional help, advice and general interest from both Paul and Matt to an extent that went quite beyond the call of duty and which contributed to the overall pleasantness of our dealings with them.
The tipis themselves are constructed from canvas supported by solid spruce poles. They provide a cosy and intimate ambience; and are suitable for all weathers. The structures are fully waterproof; they can be warmed in cold weather by firepits and merriment, while on hotter days they provide cooling shade, and the sides can be opened up to allow welcome airflow.
One thinks of a tipi as an individual cone (or 'hat', as they are seemingly known in this context; however, it is common practice to create a larger space by interconnecting two or more hats in a variety of configurations, depending on size of the site and the requirements of the event. We opted for three hats (each with a diameter of 10 metres), in a triangular configuration with one door and two archway entrances; tables and seating for 140 people beneath two hats and a dancefloor complete with glitterball and disco lighting beneath the third.
The build took two days with the main structure being created on day one and the interiors and décor being completed on day two. The team worked really hard and seemed to relish the challenge. The finished structure was simply stunning. The hat shape creates a spacious and airy interior. The raw wooden poles give a lovely sense of warmth and were adorned with hundreds upon hundreds of fairy lights to create a truly magical atmosphere. The wooden benches were dressed in sheepskins and the tables were simple but elegant; a fire pit added energy and warmth and the perfect place to light a sparkler or toast a marshmallow. The Natural Tent Company brought spare fairy lights with them and we dressed the surrounding trees to mirror the soft illumination of the tipis' insides.
I cannot praise this company enough. The product speaks for itself through the intrigue, elegance and versatility of the tipis and their décor; but Matt, Paul and their team were faultless; and we are hugely grateful to them for their hard work, energy and commitment. The lawn now looks rather bare and bereft with the tipis gone; and they would frankly have been welcome as a permanent feature.
Enquiries: The Natural Tent Company / 07766 667 496 / email@example.com / www.thenaturaltentcompany.com


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Postdoctoral Researcher - Intelligent Systems (f/m/d)
Job Description
Intel Labs is seeking a motivated postdoc in the area of intelligent systems. This is a postdoctoral position with the Intelligent Systems Lab.
In this position, you will be responsible for conceiving, researching, and prototyping new AI techniques. You will use your strong knowledge of mathematical and algorithmic techniques to identify and develop new methods in visual computing. This requires a comprehensive understanding of the state of the art.
You must also possess strong verbal and written communication skills and a demonstrated ability to work in a team-oriented environment. You are expected to maintain substantial knowledge of state-of-the-art principles and theories, and to contribute regularly to scientific literature and the research community at large.
You must possess the below minimum qualifications to be initially considered for this position. Preferred qualifications are in addition to the minimum requirements and are considered a plus factor in identifying top candidates. Experience listed below would be obtained through a combination of your work experience, graduate school, post-doc research and/or relevant internship experiences.
Please note that this position is limited to 2 years.
Minimum qualifications and experience:
- PhD in computer science, electrical engineering or similar technical discipline
- Strong software engineering background
- Strong mathematical background
- At least 3 publications in first-tier, highly selective international conferences such as CVPR, ICCV, ECCV, ICML, NeurIPS, ICLR, or SIGGRAPH
- Minimum of 3 years of research experience with two or more of the following areas:
- machine learning
- motor control
- robotics
- optimization
- computer vision
- image processing
- computer graphics
- three-dimensional modeling
Preferred qualifications:
- Strong software engineering experience demonstrated through publicly available software systems
- 5+ publications in first-tier, highly selective international conferences such as CVPR, ICCV, ECCV, ICML, NeurIPS, ICLR, or SIGGRAPH
Inside this Business Group
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Inspired by the constant encroachments of Christmas upon the rightful Halloween season, Mondo Vulgare has declared a full two months of extra spooky times with The Nightmare During Christmas. From October 31st to December 31st, they will feature wall-to-wall Halloween-themed content, and I have graciously been allowed to participate! My second contribution to The Nightmare … Continue reading Escaping the Spookhouse: HAUNT and the Lingering Trauma of Abuse
Tag: Saw
Women in Horror Month: Betty Gabriel
Welcome to Women in Horror Month at We Who Walk Here, Walk Alone! Throughout February, we will be celebrating the women who make horror the spooky, scary, and sublime genre that we all love. Betty Gabriel is a relative newcomer to the horror scene, but she has already shown that she is a talented, versatile … Continue reading Women in Horror Month: Betty Gabriel


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Bangladesh police investigating stone pelting at Australia's team bus
Police said the road was under renovation and it was likely that some small construction debris hit the window of the bus.
Published: 05th September 2017 02:10 PM | Last Updated: 05th September 2017 02:10 PM | A+A A-
CHITTAGONG: Bangladesh police say they're investigating after the Australian team bus was damaged by a small rock or stone as it travelled to the hotel after the opening day of the second cricket test, although they think it was likely related to roadworks.
Police said the road was under renovation and it was likely that some small construction debris hit the window of the bus.
"We think there was no major incident," Chittagong Metropolitan Police Commissioner Iqbal Bahar said. "The road ... went into renovation and a small piece of stone unexpectedly hit the window after coming under the security car and hit the team bus."
He said an investigation team had been formed and the route for the Australian team had been changed. Cricket Australia's security manager Sean Carroll said security had been upgraded as a precaution.
"To date, we have been happy with security measures that have been in place and we are comfortable with the response from the Bangladesh authorities and the increased security presence we have been provided in light of the incident," Carroll said in a statement. "En route to the hotel last night a window on the Australian team bus was broken. No one was injured in the incident."
The Bangladesh Cricket Board said a committee has been formed comprising security agencies to investigate, and it has taken the matter with utmost seriousness.
"The Board has been in constant communication with the Australian team management," the BCB said in a statement.
"As an added assurance, security measures have been enhanced on the travelling route of the teams. The Australia cricket team has expressed its satisfaction and comfort with the security operation in place and has appreciated the response from the BCB and the local authorities."
The Australians are undertaking their first test tour to Bangladesh since 2006 after a previous tour was delayed because of security concerns. Bangladesh won the series-opening match in Dhaka last week by 20 runs, giving the country its first test victory ever of Australia.


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Its getting near to my 1000 gig and here's a picture taken by Ralph Stephenson at the 100 cub on February 26th at the Elephant Shelf New Album Launch. It was great to see a lot of familiar faces in attendance too on a cold Tuesday in Winter.
Tag Archives: Elephant Shelf
Elephant Shelf at Blues at The Farm January 2012 doing a couple of very well known tunes.
Elephant Shelf at Blues at The Farm January 2012 doing a couple of very well known tunes.
Carry on and keep calm
I have just about got over Christmas. We were back in the studio in Burnham on Crouch yesterday and I put some accordion on one of the more rootsy tracks, which seemed to work OK.So I shall be doing a bit more of that in future though Phil Cunningham will have nothing to fear from my occasional squeezing and wheezing, mind you Allie Bain has not much to fear from my fiddling either. Due to the ongoing back and ribs problem I can only do a limited amount of playing so my skills are not going to improve that quickly on it. We have about 15 tracks of which about 10 will end on the album I think. The cold is slowly relinquishing its grasp though I felt very tired last night.
We have two gigs this Saturday, one in Billericay in the afternoon at a club called Blues at the Farm as Elephant Shelf. Not the most flattering photo on the website but hey we are quite hale though rather aged and crusty I had never heard of Billericay before that Mr Drury mentioned in one of esteemed songs.
Then one in the evening in our Delta ladies incarnation in the wilds of Barnet at the pub where Elephant Shelf had one of its very first outings (before I joined believe it or not) called the Lord Nelson.
I have it on good authority that at some point this year we will hit the 1000 gigs mark as we have averaged around 140 gigs a year in our various incarnations (Elephant Shelf Jessie Pies Cleavage of Death and the Delta ladies) which I suppose is not bad going really.
New Pre-mix track Shakedown from the forthcoming Elephant Shelf Album
Pre-final mix track from the new Elephant Shelf Album recorded at Saint FM studios produced by Pete Crisp who produced the recent Hokie Joint album – the song and the album demonstrates the band's move to retro style and sound
December 2011 continued
3 gigs this weekend one on Thursday at Cafe Rouge in Highgate that was mellow but good fun and we have been invited back in January if all go's well. One up near Baldock which didn't go quite so well as they normally have 80's cover bands so a very retro duo was not quite up their street.
On Saturday night we were at one of our favorites, the Belle Vue in High Wycombe with full band. It was a very lively night and good fun.
The live sound of the band has mellowed somewhat though its actually more energetic, and we had some very complimentary comments from the punters who are mad enough to comeback each time we are there, and so must be real gluttons for punishment. It was pretty much a party atmosphere as everyones really getting into the mood for Christmas and the band was in a somewhat joccular mood too
I record most gigs on a small pocket recorder to get a real ldea of what we sound like, thats very revealing too, sometimes when you listen back its good news and sometimes its awfull! Last nights was mostly pretty good. We put audio clips from the live stuff on the website now. We used to do a lot of video, but its impractical in a lot of places, though we should really get some new stuff done for publicity purposes.
I haven't been working on writing solo stuff though as I have been doing a lot of studying and practice and I have felt rather uninspired. Some stuff just never seems to sink in. Also I am not a big fan of Christmas though as a child I really enjoyed it a lot. New Years Eve is always a good feeling though and I try to look back at the good things that have happened though the year.
Its nearly September
Its nearly September and the year has flown by. My Ancient chariot needs to get an MOT (15 years old but only done just over 100k) and I think so do I as I have had a lot of aches and pains post gig recently. A trip to the docs is indicated me thinks. So far so good as we had a really good gig at the Cambridge Rock festival recently that should have upped our cred a bit. We also have a local london festival appearence tommorow at Abbey Fest at the Colour House Theatre on Bank Holiday Monday. We were up in Nottingham at the Trent Navigation as our duo which went well to a mixed crowd of the local blues club folks and rugby supporters so we will be back there in the not too distant future we hope. We also had recent gigs in Lincoln and a few other places. We have one more festival gig in September which is the Plumpton Beer and Blues Festival near Lewes in Sussex which could be good for us apart from the normal ongoing stuff. We are still waiting on the the rough mixes of the new Elephant Shelf Album to come through,as we we will be down in the studio again to do a bit of over dubbing as soon. We have also started recording a Delta Ladies Album and have a couple of rough tracks down for that which sound promising. I have also still got a rather iritating cough which has now eased of enough for me to get my full voice back on gigs but which nearly left me mute for the Cambridge Rock festival but I got me mojo working sufficiently for that thank goodness.


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Lizzie Brocheré Biography
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Lizzie Brocheré is a French film, TV, and stage actor. She is known as one of the best French actors of her time. She was born and raised in Paris, France, and her family was well-connected with the French entertainment industry. Her mother, Sylvie Brocheré, is a popular French casting director. Due to her mother's influence, Lizzie first became interested in acting at a tender age. She made her debut at the age of 10. Upon growing up, she started her acting career afresh and starred in films such as 'Le Loup de la côte ouest,' 'Chacun sa nuit,' and 'A French Film.' She has made her presence felt outside the French industry, too, and has also gained massive international fame. Her performance in the film 'Full Contact' helped her win the 'Best Female Actress Award' at the 'Chicago International Film Festival.' She has also delivered some critically acclaimed performances in films such as 'The Wedding Song' and 'Tellement proches.' She has also been active on TV and has appeared in series and TV films such as 'I Love Perigord' and 'R.I.S. Police scientifique.' She became a household name in the US after she starred as one of the lead characters in the series 'American Horror Story: Asylum.'
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- Lizzie Brocheré was born on March 22, 1985, in Paris, France, to popular French casting director Sylvie Brocheré. Her mother's links with the entertainment industry made Lizzie fascinated with films when she was young.While growing up, she spent a lot of time with her mother on her job. Sometimes, she even helped her mother with finding the right actors for the right roles. Being around struggling actors most of the time prepared her to go through the journey, too. She also got enough chances to meet film producers, which further helped her know about the inner workings of the film industry.She had started acting in films when she was 10 years old. She was also getting inclined toward other artistic activities. She studied literature and film from 'Sarbonne University' in Paris. Following her graduation, she enrolled at the 'ESCP Business School,' were she learned media management.She intended to become a film producer/director. Additionally, she also did internships at a few production houses.Continue Reading BelowYou May LikeRecommended Lists:
Recommended Lists:Career
- With her mother's influence, she made her acting debut at the age of 10. Her debut role was that of a young girl in the series 'Parents à mi-temps.' In 2001, at the age of 16, she made her full-fledged acting debut, starring in the lead role in the French TV film titled 'Margaux Valence: Le Silence d'Alice.'The same year, she also appeared in guest roles in series such as 'Relic Hunter' and 'Joséphine, ange gardien.'2002 was a huge year for Lizzie, as in that year, she made her film debut and had her major TV breakthrough. Her debut film was 'Le Loup de la Côte ouest.' She also appeared in a key role in the TV film 'Une autre femme.'Soon, she also started appearing in a recurring role in the series 'Alex Santana, négociateur – Un ange noir.' She played the role of 'Eva' in seven episodes of the series.Throughout the early 2000s, she appeared in supporting roles in films and guest roles in TV series.After appearing in lead roles in the short films 'Papier glacé' and 'Septembre et moi' in the mid-1980s, she bagged the first lead role of her film career in the film titled 'Le Chant des mariées.' Lizzie played a poor Tunisian Muslim girl in the film. It was highly appreciated by critics.In the mid-2000s, her TV career also picked up a good pace. She appeared in a supporting role in 14 episodes of the series titled 'R.I.S Police scientifique- Une vie brisée.'Around the same time, she appeared in key roles in TV films such as 'Aves le temps...' and 'Bac +70.' Her performance in 'Bac +70' was heavily praised, and she ended up winning the 'Best Young Actress Award' at the 'Luchon International Film Festival.'In the late 2000s, her film career picked up a great pace, as she was on her way to become a major star in the French film industry. She first appeared in the film titled 'Tellement proches,' followed by 'Linear.' 'Linear' was a heavily experimental film. Lizzie had earlier expressed her desire to do more such films to explore the art of filmmaking in a more refined way.Continue Reading BelowIn 2011, she appeared in a lead role in the critically acclaimed film 'American Translation.' The same year, she appeared in a supporting role in the film titled 'Sleepless Night.' The thriller film premiered at the 'Toronto Film Festival' and was praised universally upon its release. However, the film struggled poorly at the box office.In the more recent years, she has gained a huge fan following in the US. In 2012, she was signed to play one of the lead roles in the horror–drama series titled 'American Horror Story: Asylum.' She did not personally audition for the film and sent an audition tape to the producers instead. She traveled to the US only after she was selected to play the role of 'Grace Bertrand.'The second season of 'American Horror Story: Asylum' ran for 13 episodes and was received positively by critics. The TV ratings indicated a strong commercial appreciation, too. The series also exposed her to the American audiences, and more American filmmakers approached her.In 2015, she appeared in the lead role of 'Cindy' in the war drama 'Full Contact.' The film premiered at the 'Chicago International Film Festival,' where she earned the award for the 'Best Female Actor.'In 2017, she appeared in the supporting role of 'Kelly' in the American horror film 'Rings.' The film was thrashed by critics but was a box-office success.In addition, she was also seen playing key roles in series such as 'The Strain' and 'Falling Water.' She has also played a supporting role in the historical drama series 'Versailles.'She directed, co-wrote, and produced the 2017 short film 'Terre ferme.'Recommended Lists:
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- Lizzie Brocheré has been in a long-term relationship with popular French actor Pierre Perrier.Lizzie is also an active philanthropist and works with an organization called 'Iemanja.' She started the organization with Leo Leibovici. Its main work is to spread awareness about the environment and to establish a connection between different cultures and generations.Recommended Lists:
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How To CiteArticle Title- Lizzie Brocheré BiographyAuthor- Editors, TheFamousPeople.comWebsite- TheFamousPeople.comURL- https://www.thefamouspeople.com/profiles/lizzie-brocher-45184.phpLast Updated- July 02, 2019
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Responding to the Floods in Pakistan: August 20, 2010
In the last week of July 2010, torrential rains caused devastating floods in large parts of Pakistan. As many as 1,500 people have died in what officials have called Pakistan's worst flooding in 70 years and has affected the lives of nearly 14 million people, according to estimates from the United Nations. The number is expected to grow significantly as flood waters pass through Southern parts of the country and as information from remote areas become more available.
Here we've listed several key organizations working and supporting on-the-ground relief. For donors who would like to make a gift from their fund, please contact your philanthropic advisor, Audrey, Rob, Erin or Barrett, at 404-688-5525. Others who are interested can visit the organizations website and make a gift directly.
CARE – CARE is supporting health teams, mobile clinics and the distribution of emergency supplies in the wake of flooding that has devastated wide swaths of the country.
Church World Service – CWS is coordinating a response in a wide geographic area, though given the changing scope of the disaster, specific information on location of distributions of food and non-food assistance and recipients is frequently changing.
Give2Asia – To address increasing needs, Give2Asia will work with its network on the ground to identify local organizations in Pakistan responding to the disaster. Immediate needs include evacuation and rescue, timely provision of food and personal hygiene items and shelter-related needs.
International Rescue Committee – Immediate program assistance for flood affected areas will focus on water, sanitation and hygiene (WASH), non-food item distributions and shelter.
Map International – MAP International continues to monitor the situation in Pakistan and is coordinating with in-country health institutions and programs for the delivery and dispensing of medicines and medical services.
Oxfam – Oxfam and its partners have launched a rapid-relief effort to quickly reach 400,000 people in hard-hit areas of Punjab, Balochistan and Khyber Pakhtunkhwa with essential aid.
Red Cross – To meet the immediate humanitarian needs from the flooding, the global Red Cross network is providing food, relief items, shelter, water and sanitation services and emergency healthcare.
UNICEF – UNICEF and partners have set up nine medical camps and are providing medicine, water treatment tablets, nutritional supplements, hygiene kits and jerry cans.
World Vision – World Vision has begun distributing food and water to flood survivors and plans to provide medical assistance, shelter, hygiene kits and other basic relief items as soon as possible.
For more information, we've included additional resources specific to the Pakistan floods:
- The United Nations Office for the Coordination of Humanitarian Affairs (OCHA)
- ReliefWeb: A project of the United Nations Office for the Coordination of Humanitarian Affairs. This Web site serves as a clearing house for information related to the earthquakes and ongoing situational reports on the Pakistan floods.
- AlertNet: A humanitarian news network from the Reuters Foundation that provides detailed news updates on the extent of damage and ongoing humanitarian relief efforts.
- InterAction, the largest alliance of U.S.-based international nongovernmental organizations (NGOs), lists their members responding to the floods in Pakistan.
- Give2Asia launched a Pakistan Flood Relief Fund after receiving initial commitments of $30,000 from private donors wishing to help survivors.


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The correlation between molecular and histopathological features of melanocytic tumors is still largely incomplete. From a practical point of view, however, only a very limited number of cases seen in clinical practice run the entire spectrum of molecular and biological progression of melanomagenesis; thus, the molecular progression model has a very limited clinical impact. Rather than intermediate stages in an unlikely path toward melanoma, melanocytomas are probably best regarded as morphobiologically peculiar melanocytic tumors, namely, strongly lymphotropic (low-grade) melanocytic malignancies; their clinical management should be thus discussed case by case in a multidisciplinary setting by integrating the histopathological findings with the clinical data.
- Genomic landscape of melanoma Bastian BC, de la Fouchardiere A, Elder DE, et al. Elder DE, Massi D, Scolyer RA, Willemze R. WHO Classification of Skin Tumours.2018;:72-75.
- An update on molecular alterations in melanocytic tumors with emphasis on spitzoid lesions Dimonitsas E, Liakea A, Sakellariou S, et al. Ann Transl Med.2018;6(12):249-265.
- A distinct subset of atypical Spitz tumors is characterized by BRAF mutation and loss of BAP1 expression Wiesner T, Murali R, Fried I, et al. Am J Surg Pathol.2012;36(6):818-830.
- Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi Yeh I, Lang UE, Durieux E, et al. Nat Commun.2017;8(1):644.
- Genomic analysis of pigmented epithelioid melanocytomas reveals recurrent alterations in PRKAR1A, and PRKCA genes Cohen JN, Joseph NM, North JP, et al. Am J Surg Pathol.2017;41(10):1333-1346.
- Genomics of cutaneous melanoma: focus on next-generation sequencing approaches and bioinformatics Papadodima O, Kontogianni G, Piroti G, Maglogianni I, Chatziioannou A. J Transl Genet Genom.2019;3:7.
- Nevus/melanocytoma/melanoma: an emerging paradigm for classification of melanocytic neoplasms? Zembovicz A, Scolyer RA. Arch Pathol Lab Med.2011;135(3):300-306.
- The transformation rate of moles (melanocytic nevi) into cutaneous melanoma: a population-based estimate Tsao H, Bevona C, Goggins W, Quinn T. Arch Dermatol.2003;139(3):282-288.
- β-Catenin nuclear expression discriminates deep penetrating nevi from other cutaneous melanocytic tumors De la Fouchardière A, Caillot C, Jacquemus J, et al. Virchows Arch.2019;474(5):539-550.
- Molecular diagnostics in melanocytic tumors: the pathologist's perspective Ferrara G, Improta G. Adv Mol Diag.2016;1(1).
- Fluorescence in-situ hybridization for melanoma diagnosis: a review and a reappraisal Ferrara G, De Vanna AC. Am J Dermatopathol.2016;38(4):253-269.
- Melanocytic tumors of uncertain malignant potential: results of a tutorial held at the XXIX Symposium of the International Society of Dermatopathology in Graz, October 2008 Cerroni L, Barnhill R, Elder D, et al. Am J Surg Pathol.2010;34(3):314-326.
- Atypical Spitz tumours and sentinel lymph node biopsy: a systematic review Lallas A, Krygidis A, Ferrara G, et al. Lancet Oncol.2014;15(4):e178-e183..


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- Name
- Belatacept
- Accession Number
- Type
- Biotech
- Groups
- Approved, Investigational
- Biologic Classification
- Protein Based Therapies
Fusion proteins
- Description
Belatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it is a homodimer of two homologous polypeptide chains of 357 amino acids each. It is produced through recombinant DNA technology in mammalian CHO cells. The drug has activity as a selective co-stimulation modulator with inhibitory activity on T lymphocytes. It is approved for the treatment of rheumatoid arthritis. Belatacept selectively blocks the process of T-cell activation. It was developed by Bristol-Myers-Squibb. Belatacept is only 2 amino acids different from abatacept (Orencia). FDA approved on June 15, 2011.
- Protein chemical formula
- Protein average weight
- 92300.0 Da (with glycosylation)
- Sequences
> sequence for belatacept MHVAQPAVVLASSRGIASFVCEYASPGKYTEVRVTVLRQADSQVTEVCAATYMMGNELTF LDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYEGIGNGTQIYVIDPEPC PDSDQEPKSSDKTHTSPPSPAPELLGGSSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPA PIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENN YKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKDownload FASTA Format
- Synonyms
- Not Available
- External IDs
- Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing EndUnlock Additional Data Nulojix Injection, powder, lyophilized, for solution 250 mg/1 Intravenous E.R. Squibb & Sons, L.L.C. 2011-06-15 Not applicable Nulojix Injection, powder, for solution 250 mg Intravenous Bristol Myers Squibb Pharma Eeig 2011-06-17 Not applicable Nulojix Injection, powder, for solution 250 mg Intravenous Bristol Myers Squibb Pharma Eeig 2011-06-17 Not applicableAdditional Data Available
- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.Learn more
- Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.Learn more
- Categories
- Amino Acids, Peptides, and Proteins
- Antibodies
- Antineoplastic and Immunomodulating Agents
- Antirheumatic Agents
- Blood Proteins
- CD80-directed Antibody Interactions
- CD86-directed Antibody Interactions
- Globulins
- Immunoconjugates
- Immunologic Factors
- Immunoproteins
- Immunosuppressive Agents
- Noxae
- Proteins
- Selective Immunosuppressants
- Selective T Cell Costimulation Blocker
- Serum Globulins
- T Lymphocyte Costimulation Activity Blockade
- Toxic Actions
- CAS number
- 706808-37-9
- Indication
For prophylaxis of organ rejection. It is also used concomitantly with basiliximumab for induction therapy, mycophenolate, and corticosteriods in kidney transplant recepients that are seropositive for the Epstein-Barr virus.
- Associated Conditions
- Pharmacodynamics
Belatacept binds to CD86 with a 4-fold higher affinity than abatacept. It also binds to CD80 with a 2-fold higher affinity than abatacept. It was observed in non-human primates that belatacept prolongs graft survival due to a decrease in antibody production against the donor organ. Furthermore, belatacept also inhibits the primary humoral immune response which is indicated by the decrease in post-transplant levels of IgG, IgM, and IgA. The magnitude of this effect is more significant in belatacept than it is in cyclosporine.
- Mechanism of action
Belatacept is a fusion protein in which the Fc portion of human IgG1 is attached onto the extracellular portion of human CTLA-4 (CD152). Belatacept specifically binds to CD80 and CD86 receptors that are found on the antigen-presenting cell (B cells, macrophages, dendritic cells) to block selective T-cell lymphocyte costimulation. CD80 and CD86 would normally act as the ligands to the CD28 receptor T-cells in which this interaction triggers the activation of T lymphocytes. However in the presence of belatacept, because the extracellular CTLA-4 component binds to CD28 with higher affinity than CD80 or CD86, T lymphyocyte anergy, a state of antigen specific tolerance, occurs instead. The T cell is also no longer able to respond to their antigen.
Target Actions Organism AT-lymphocyte activation antigen CD86antagonist Humans AT-lymphocyte activation antigen CD80antagonist Humans
- Absorption
Following multiple intravenous doses of an initial 10 mg/kg dose and followed by a maintenance dose of 5 mg/kg in kidney transplant recipients, these are the following pharmacokinetic parameters: Cmax, 10 mg/kg = 247 µg/mL; Cmax, 5 mg/kg = 139 µg/mL; AUC, 10 mg/kg = 22,252 µg · h/mL; AUC, 5 mg/kg = 14,090 µg · h/mL; Belatacept had linear and dose-dependent pharmacokinetic profile.
- Volume of distribution
Vd, steady state, transplant patients, 10 mg/kg = 0.11 L/kg; Vd, steady state, transplant patients, 5 mg/kg = 0.12 L/kg
- Protein binding
- Not Available
- Metabolism
The cytochrome P450 enzyme system or uridine diphosphate-glucuronosyltransferases are not expected to be involved with the metabolism of belatacept. Because the drug is a protein, belatacept is degraded into smaller peptides and amino acids by proteolytic enzymes.
- Route of elimination
- Not Available
- Half life
Mean terminal elimination half-life: 10 mg/kg, kidney transplant recipients= 9.8 days; 5 mg/kg, kidney transplant recipient = 8.2 days
- Clearance
Increased body weight may increase the clearance rate of belatacept. Mean systemic clearance: 10 mg/kg, kidney transplant recipients= 0.49 mL/h/kg; 5 mg/kg, kidney transplant recipient = 0.51 mL/h/kg.
- Toxicity
- Not Available
- Affected organisms
- Humans and other mammals
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.Learn more
Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.Learn more
Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.Learn more
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug InteractionUnlock Additional Data 2-Methoxyethanol The risk or severity of adverse effects can be increased when 2-Methoxyethanol is combined with Belatacept. 9-(N-methyl-L-isoleucine)-cyclosporin A The risk or severity of adverse effects can be increased when Belatacept is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A. Abatacept The risk or severity of adverse effects can be increased when Abatacept is combined with Belatacept. Abetimus The risk or severity of adverse effects can be increased when Abetimus is combined with Belatacept. Acteoside The risk or severity of adverse effects can be increased when Belatacept is combined with Acteoside. Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Belatacept. Adenovirus type 7 vaccine live The risk or severity of infection can be increased when Adenovirus type 7 vaccine live is combined with Belatacept. Afelimomab The risk or severity of adverse effects can be increased when Afelimomab is combined with Belatacept. Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Belatacept. Aldosterone The risk or severity of adverse effects can be increased when Aldosterone is combined with Belatacept.Additional Data Available
- Extended DescriptionExtended Description
Extended description of the mechanism of action and particular properties of each drug interaction.Learn more
- SeveritySeverity
A severity rating for each drug interaction, from minor to major.Learn more
- Evidence LevelEvidence Level
A rating for the strength of the evidence supporting each drug interaction.Learn more
- ActionAction
An effect category for each drug interaction. Know how this interaction affects the subject drug.Learn more
- Food Interactions
- Not Available
- General References
- Wekerle T, Grinyo JM: Belatacept: from rational design to clinical application. Transpl Int. 2012 Feb;25(2):139-50. doi: 10.1111/j.1432-2277.2011.01386.x. Epub 2011 Dec 7. [PubMed:22151353]
- Garnock-Jones KP: Belatacept: in adult kidney transplant recipients. BioDrugs. 2012 Dec 1;26(6):413-24. doi: 10.2165/11208900-000000000-00000. [PubMed:22928660]
- External Links
- KEGG Drug
- PubChem Substance
- 347910359
- RxNav
- 1112973
- ChEMBL
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Belatacept
- ATC Codes
- L04AA28 — Belatacept
- FDA label
- Download (582 KB)
- Download (479 KB)
Clinical Trials
- Clinical Trials
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage forms
Form Route Strength Injection, powder, for solution Intravenous 250 mg Injection, powder, lyophilized, for solution Intravenous 250 mg/1
- Prices
- Not Available
- Patents
- Not Available
- State
- Liquid
- Experimental Properties
- Not Available
- Description
- Not Available
- Kingdom
- Organic Compounds
- Super Class
- Organic Acids
- Class
- Carboxylic Acids and Derivatives
- Sub Class
- Amino Acids, Peptides, and Analogues
- Direct Parent
- Peptides
- Alternative Parents
- Not Available
- Substituents
- Not Available
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Antagonist
- General Function
- Virus receptor activity
- Specific Function
- Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cel...
- Gene Name
- Uniprot ID
- Uniprot Name
- T-lymphocyte activation antigen CD86
- Molecular Weight
- 37681.97 Da
- Vincenti F: Costimulation blockade in autoimmunity and transplantation. J Allergy Clin Immunol. 2008 Feb;121(2):299-306; quiz 307-8. doi: 10.1016/j.jaci.2008.01.002. [PubMed:18269922]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Antagonist
- General Function
- Virus receptor activity
- Specific Function
- Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects an...
- Gene Name
- Uniprot ID
- Uniprot Name
- T-lymphocyte activation antigen CD80
- Molecular Weight
- 33047.625 Da
- Yabu JM, Vincenti F: Novel immunosuppression: small molecules and biologics. Semin Nephrol. 2007 Jul;27(4):479-86. [PubMed:17616278]
- Tedesco Silva H Jr, Pinheiro Machado P, Rosso Felipe C, Medina Pestana JO: Immunotherapy for De Novo renal transplantation: what's in the pipeline? Drugs. 2006;66(13):1665-84. [PubMed:16978033]
Drug created on March 19, 2008 10:48 / Updated on March 01, 2020 19:43


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- Port Louis Tour & Turtle Bay Marine Park [customized]Full-day cruise with lunch and refreshments
- This full-day cruise takes you south of Grand Bay, along the spectacular west coast of Mauritius and all the way to the Caudan Waterfront at the heart of Port Louis – which is a "Must See" for anyone visiting Mauritius. Set against a backdrop of magnificent sea and mountain views, the bustling Waterfront abounds with exciting shopping and entertainment venues intermingled with world-class hotels and restaurants ooverlooking the Port Louis Harbor. Its craft market in particular is a hive of activity with wonderful ambiance where you are sure to find all the souvenirs for the family back home.From the Waterfront, you will climb onboard a comfortable, air conditioned minibus and venture into the labyrinth-like streets of Port-Louis in search of Mauritius' fascinating colonial past. This wonderfully informative guided tour will take you to such landmarks as the famous Port-Louis Market, the Champ de Mars, the Citadel, and the Aapravasi Ghat (a UNESCO World Heritage Site).
- Dolphin Watching & West Coast Explorer [customized]
- Full-day cruise with lunch and refreshments If you have ever dreamed of getting up close and personal with wild dolphins, don't miss your opportunity! We set sails early from Grand Bay and head south towards Tamarin and its resident population of bottlenose and spinner dolphins. By the time we get there the dolphins – sometimes up to 200 of them – will be busy playing and splashing around and you may even get a chance to swim with them! Although the dolphins of Tamarin are certainly a highlight of this cruise, we very often come across whales and dolphins all along the west coast. This is a coastline of outstanding natural beauty, dotted with spectacular sea cliffs and historical sites. We will sail past the magnificent Albion Lighthouse, one of only two lighthouses that remain in operation (along with the one atop Flat Island). The Albion lighthouse was inaugurated in 1910 and still serves as a precious beacon to the incoming ships travelling to Port-Louis with its imposing height.After your wild encounter with dolphins, you will have plenty of opportunities to snorkel in crystal clear waters among countless colourful tropical fish while your crew will be busy preparing a sumptuous BBQ buffet. In the background, Le Morne Brabant, perhaps Mauritius' most famous landmark, will provide great photo opportunities!
- Isla Mauritia-an unforgettable cruise along the coast of Mauritius aboard this unique sailing vessel [customized]
- Dont miss the opportunity of an unforgettable cruise along the coast of Mauritius aboard this unique sailing vessel. ISLA MAURITIA was built in 1852 by the famous shipbuilders Sollier of Spain. Through their dedication and craftsmanship they spent years transforming ninety tons of exceptionally tough and durable pine into a sailing vessel of lasting elegance and strength. She was designed according to the traditional style of the world famous Balearic Island Schooners, which used to transport freight between Europe and Africa and were renown for their sailing expertise. Her history covered several generations in the safe keeping of one family who painstakingly maintained her to a standard of excellent working order. During this period, her structure and equipment was continually updated to ensure her trading capability until 1959 when she finally sank under mysterious circumstances. She was designed according to the traditional style of the world famous Balearic Island Schooners, which used to transport freight between Europe and Africa and were renown for their sailing expertise.
- CATAMARAN CRUISE-Ilot Gabriel [in packages]
- We leave from Sunset Boulevard in Grand Bay at 09:00 every morning to return at 16:30 at the same place. We are serving breakfast in the morning with coffee, tea, juice, fresh croissant and pain au chocolate. We supply suncream for free, you are able to buy ROC suncream which is a very high quality suncream on board. We supply towels as well as good snorkeling gear. The sailing time is around 1,5 hours before we reach the Islands. At around 12.30 we have a BBQ lunch on the boat itself. We are using only fresh fish, chicken and all fresh salads. If you are a vegetarian, please advice us before, so we can arrange the necessary. There is a very nice lagoon, where swimming and snorkelling are a must. Enjoy the white sand beaches to sun bath or just take a nice walk at the Island. There is a nice wildlife on the Islands where birds such as the Paille en Queue and other species like gecko's and lizards are staying. Do note that we serve all drinks such as coke, diet coke, sprite, fanta, tonic, soda, red wine, white wine, rose, Green island rum, Whiskey, Vodka and Gin all day long. There will be live music on the Island and during the return trip to Grand Bay. We will return around 15:00 and arrive at 16:30. At certain times a year we will see whales as well as dolphins. If so, we stop the boat and enjoy these animals passing by. Pick-up with our minivan can be organized, as well as a drop off at your accomodation. We charge a very small fee for this.


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US News and World Report recently pointed to Northwestern's Kellogg School of Management as the nation's top educational institution for aspiring marketers. Among the likes of Penn, Harvard, Stanford, and Columbia, what makes Northwestern's program stand out from the crowd?
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From Warren Buffett's Stunning Video Testimonial
I have to tell you I now have nine suits all made in China; I threw away the rest of my suits. Our directors, my partner Charlie Munger, Walter Scott, Ron Olson and even Bill Gates now, are wearing suits made by Dayang Trands. And they know and love Madam Li for what she's accomplished. As a matter of fact I think maybe Bill Gates and I should start a men's clothing store and sell the suits made by Madam Li. I think we would be great salesmen, because we love them so much. The suits we've received that have been made in China we've never had to alter a quarter of an inch. They fit perfectly. We get compliments on them. It's been a long time since I got compliments on how I looked. But since I'm wearing Madam Li's suits I get compliments all the time. So maybe Bill and I can start a clothing store. And if we sold the suits made by Dayang Trands someday we might even be rich, who knows.
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