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Tom Clancy's Rainbow Six 3 Xbox
by Ubi Soft Entertainment
Developed by Red Storm Entertainment
Released: Out Now
Price: £39.99
I think it's hard to over estimate the influence that the original Rainbow Six game had on games developers. Tom Clancy's Rainbow Six was the first real game where you couldn't simply go in all guns blazing and had to adopt a very cautious approach. Despite the difficulty though gamers loved it and it still remains a popular title to this day. In fact the prefix 'Tom Clancy's' has served a seal of approval on a wide range of tactical games with last year's Splinter Cell being a superb title. As the title suggests this is the third in the Rainbow Six series and the first in the series to arrive on Xbox.
Rainbow Six 3 puts you in the shoes of Ding Chavez, the top man at Rainbow. The game is set in the year 2007. America is caught in an embargo which has led to an oil crisis and to make matters worse American citizens have become a target for terrorist attacks. Venezuela, which has been providing the US with oil has also been targeted for terrorist attacks. It's a nightmare of a problem and it's up to Rainbow to sort out the mess whilst keeping civilian casualties to an absolute minimum. In all there are 14 single player missions (and a choice of 3 difficulty levels) and any mission that has been completed can be played again in the custom mission mode.
Rainbow Six 3 is slightly different from the previous Rainbow Six titles that were on the PC. You don't have any complicated pre-mission strategies to work out. In my opinion this is no bad thing and the game is the most accessible in the series and flows a lot more freely as a result. The developers have done a superb job in bringing the game to the Xbox. The controls are spot on and at no point did I ever feel the need for a keyboard and mouse. The game has more pace than the previous Tom Clancy titles on Xbox (Ghost Recon, Island Thunder and Splinter Cell) and I would say it's the most immersive Tom Clancy title to date. The enemy AI in the game is also very good and going in with an all guns (or which ever of the 30 included weapons you prefer) blazing approach will get you nowhere, which is the way it should be with a title such as this.
If you've followed the development of the game you'll know that the game is capable of receiving voice orders using either the Xbox Live headset or by buying the game with the included headset (there is also a version without a headset too). Some of you may have been worried about this, as this is a feature that whilst it's absolutely superb for hearing gamers, is redundant for deaf gamers. There is no need to worry though as orders can be given just as easy through a context sensitive menu. These orders are given via the directional pad and the whole process is quick and simple. You can also quickly give follow or regroup commands by pressing the black button. The current order is displayed onscreen so you'll know what your men are doing.
Ghost Recon and Island Thunder have been very successful on Xbox Live and Rainbow Six certainly looks like it's going to continue that trend with many thousands taking the game online after just going on sale in the US. Using the Xbox Live mode allows you to play through all of the games missions co-operatively with three other gamers, which is certainly an excellent inclusion. You can also play a variety of games such as sharpshooter and survival. There is additional content to download already, a map called Garage, and no doubt there will be more to follow. You have the usual quick match, optimatch and the ability to create a game and you can even block voice chat in your created games to even up the score if you're playing against hearing gamers. If you don't have Xbox Live then you can play system link games for 1-16 players.
When Ubi Soft released Tom Clancy's Splinter Cell last year everyone was impressed with the graphics, including us, and Rainbow Six 3 is certainly just as impressive. Both the night and thermal vision looks stunning and makes full use of the Xbox's graphical capabilities. The character models have been well done too. The best part of the game, graphically speaking, has to be the explosions which look magnificent and I was surprised to see that the framerate didn't suffer (it remains smooth throughout the whole of the game) when these explosions occur. The game features quite a few diverse locations and they are all pleasing to look at.
On the whole Rainbow Six 3 is a truly brilliant game and definitely one of the best on the Xbox. However, there are a few problems for deaf gamers. The cutscenes aren't subtitled but this isn't really a problem because the mission briefing is given in text and in truth it provides more detail than the cutscenes. Your onscreen map doesn't show the locations of your enemies which is realistic but this makes it more difficult for deaf gamers. Your men will warn you if an enemy is behind you but there are no subtitles for these warning and the first you'll know of it is when a bullet flies past you. As you can imagine this is going to increase the difficulty a little for deaf gamers. It isn't so much of a problem in the open spaces because you can switch to your thermal vision and use the scope on your weapon to spot enemies from a good distance away but when indoors this isn't such a viable precaution to take.
Thankfully you are able to save up to 3 times in a mission, so if you use these saves wisely you shouldn't ever lose too much progress. It's important to bear in mind that you can't quit a mission and resume progress at a later date. The three saves that you have (on recruit level) are only temporary place holders and will only remain available whilst you are in a mission. The mission briefings can be recalled but for some reason it takes you out of the mission and all your progress will be lost which is unfortunate, however you are warned of this beforehand. The tutorial is fully subtitled so you'll have no problem at all getting to grips with the controls. Any items that can be interacted with will cause an icon to appear in the lower middle of the screen when the crosshair is placed over them, which again is good to see.
Rainbow Six 3 may be more difficult for deaf gamers but it's far from impossible and if you appreciate tactical FPS games, even only a little, you'll simply be bowled over by just how polished and playable this game is. In fact aside from a few areas not being subtitled it's difficult to pick fault with the game. Left handed gamers will also be pleased to note that two southpaw (left handed) control schemes are also available where the the controls for the right and left analogue sticks are exchanged. How often do you see that in a game? In short then it will prove slightly more difficult for deaf gamers but it's still a superb title and if you are a fan of this genre then it is definitely recommended.
Game Rating: 8.5/10
Rainbow Six 3 is definitely another Xbox classic and is recommended. We have lowered the mark because of the increased difficulty for deaf gamers but if you are a fan of the genre you simply must own this title.
Gamers comment:
There are a few problems and it would have been good if your companions comments about nearby enemies etc., could have been subtitled.


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MA History Distance Education in Chennai, Tamilnadu
Information About MA History Distance Education in Chennai, Tamilnadu
|Admissions Procedure
|Fee Structure
|Students to pay Rs 12,600 per year/*
|2 year
|Eligibility Criteria
|Need to be 10th pass
|Approved by UGC /DEB and the AICTE
|Offered By
Fee Structure of Distance Education MA History to Chennai, Tamil Nadu
The MA History Course fee structure is Approximate and it can be changed also. The students who have passed the examination of Graduation from universities they can apply for this course and pay the eligibility fee for MA History Distance Education in Chennai, Tamilnadu.
MA History Distance Education in Chennai, Tamilnadu Duration
MA in History is a 2-year PG course. The duration of the course is minimum two years and the maximum is a 4-5 year. Its also may vary in some colleges/universities. There are total 4 semesters spread over the span of 2 years. Exams are held at the end of each semester.
MA History Distance Education Syllabus
|Year I
|Subjects of Study
|History of India up to 300 B.C.
|Twentieth Century world (up to the end of World War II)
|Nineteenth-Century India or Women in Indian History
|History of the Marathas (A.D. 1600 – A.D. 1707) or History of Republican China
|Year II
|State, Society, and culture of India (B.C.300–A.D. 500)
|Polity in Medieval India
|Nineteenth-Century Maharashtra or Dalit Movement under Dr. Babasaheb Ambedkar (A.D. 1920 – A.D. 1956)
|History of the Marathas (A.D. 1707 – A.D. 1818) or World after World War II
What are the Benefits of MA History Distance Education?
If someone working in any organization as well as want to study, Then they can apply for MA History Distance Education.
Course After 12th
|Political Science
|Human Development
More Cities
|Tamil Nadu
|Chandigarh (Punjab)
|New Delhi
MA History through Distance Learning in India.
More information contact number +91-9210989898
Looking For Help? Talk to Us

subset: commoncrawl


text:
In December 2019, CIMIC Group company CPB Contractors has been awarded three work packages at Rio Tinto's Robe Valley operations located in the Pilbara region of Western Australia. The works - with a total value of $150 million - will include earthworks and civil works.
"We are pleased to be working on one of the largest and most important mining operations in Australia. CPB Contractors is committed to delivering these projects to the highest safety and quality standards and we're proud to provide significant training and employment opportunities for local communities and Indigenous enterprises," CPB Contractors Managing Director Juan Santamaria said.
CPB Contractors will be delivering works including earthworks; construction of roads, bridges and pits; water supply infrastructure and drainage; fencing; as well as site establishment and demobilisation. The works are due to be completed by the end of 2021.
To deliver these projects, close coordination with Rio Tinto and other contractors working on site is required.
The Robe Valley operations are located approximately 140 kilometres southwest of Karratha.
In late 2018, Rio Tinto and its joint venture partners Mitsui and Nippon Steel & Sumitomo Metal invested $1.55 billion to sustain production at the Robe Valley Joint Venture. You can read more about it here.
Get the latest industry news and project updates straight to your inbox by subscribing to the PlantMiner blog today.
Source: CPB Contractors; Australian Mining; Mining Magazine; Mining Technology


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Atacama Desert
The Atacama is a popular region of cinematic rock formations, billowing geysers and expansive salt flats.
Contrast the salt flats, geysers and moonscapes of the arid north with the lakes, glaciers and temperate forests of Patagonia.
Chile is a country defined by its diverse landscapes, which range from the pristine lakes, towering peaks and glaciers of Patagonia to the huge rock formations and geysers of its arid north, via the lush Andean vineyards of the Central Valley.
One of the most iconic images of Chile is that of the the distinctive 'Los Cuernos' horn-shaped peaks in the Torres del Paine National Park in Patagonia, one of the best national parks anywhere in the world, particularly for hiking enthusiasts. Both north and south of here you can embark on expedition cruises to immense remote glaciers. Northern Patagonia is dominated by the Chile's Lake District, an outstanding area of natural beauty, whose glistening lakes, verdant forest and European style towns give it a distinctly alpine feel.
Heading north, Chile's central region is charactarised by its pristine vineyards, especially those clustered around the capital Santiago and in the Santa Cruz wine region. The spectacular Atacama Desert spreads out across the north of the country, famed for its cinematic rock formations, vast salt flats, flamingo-filled lagoons and billowing geysers, in total contrast to the landscape experienced in the south.
The Atacama is a popular region of cinematic rock formations, billowing geysers and expansive salt flats.
Santa Cruz provides a base from which you can explore the largest wine region in Chile, producer of an outstanding array of r…
Mountain town on the shore of Lake Villarica in the heart of the beautiful Lake District and overlooked by a snow-capped act…
The ideal base from which to discover the alpine scenery, German heritage and fishing communities of the region.
Cruise through stunning fjords to lush mountains, sculptured icebergs, colourful fishing villages to the spectacular San Rafa…
Follow the Kawaskar route from Puerto Natales through the fjords, bays and immense glaciers of the Southern Patagonian Ice Fi…
Snow-covered mountains, dense forest, turquoise lakes and electric-blue icebergs await in Torres del Paine.
13 Nights from £4,335
Discover the 'thin country' between the Andes and Pacific visiting the Atacama Desert, green lakes, mighty volcanoes in the Lake District and the glaciers of Torres del Paine
12 Nights from £2,724
Explore the stunning mountain scenery of majestic volcanoes, lakes and picturesque villages driving at your own pace, making stops and detours as your whim desires
13 Nights from £5,447
A fascinating contrast of the Atacama Desert landscapes of salt flats, Tatio geysers and high mountains with a cruise along the Chilean Fjords with lush forests, hot springs a…
17 Nights from £5,116
Explore a land of glaciers and stunning landscapes in Tierra del Fuego on a 4 night Patagonia cruise, combined with Andean landscapes and the glistening Lake District
18 Nights from £4,282
Andean landscapes of the Lake District across the mountains to explore Patagonia Glaciers and Tierra del Fuego. Cosmopolitan Cities with a modern lifestyle and excellent resta…


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Jenny's 2010 Picks
|Tad Hills
|Schwartz & Wade/Random House, 2010.
5 stars
|Keywords: friendship how-rocket-learned-to-read humor independence seasons tad-hills
How Rocket Learned to Read
by Tad Hills
If your child is starting to match letters with their sounds and perhaps recognize a word or two, you are in luck! This charming book tells a multilayered story about learning to read and making a friend, through a series of very simple words and images. A shift in palette conveys the passage of time, and the changes in the puppy hero's expressions and body language indicate the furry pupil's gradual openness to his little feathered teacher's patient and persistent overtures.
First off, we meet Rocket, a dog who loves to play: "He loved to chase leaves and chew sticks. He loved to listen to the birds sing." One day, after a full morning of play, just when he's "settl[ing] in for a good nap," a little yellow bird alights on Rocket's tufted forehead. "Aha! My first student! Wonderful!" she sings. Rocket responds by moving on to a new napping place. When the bird begins the story of an unlucky dog, Buster, who's lost his favorite bone, we see only the tip of Rocket's tail protruding from a bush. "At first Rocket was disturbed," and his expression shows it. But as Buster's story progresses, Rocket perks up. The little yellow bird flies off, leaving her furry listener on a cliff-hanger.
Now the pooch is hooked, and "every day Rocket returned to the little yellow bird's classroom." Each morning, Rocket learns a new letter, and student and teacher put the letters together. Hills delightfully drives the plot with the sounds the letters make: with "G" and "R" they spell brown-and-white spotted Mr. Barker's growl ("GRRRRRRRRRR!"). Hills makes children aware of the omnipresence of sounds of all kinds—a dog's growl, the whoosh of the wind. Meanwhile, the sky darkens, and the leaves turn "R-E-D." It's fall—time for the little yellow bird to head South. "Don't forget! Words are built one letter at a time!" she cries as she flies off. In her absence, Rocket practices his letters; a snowy field becomes his whiteboard. He traces "A-B-C" in the snow, and sounds out "W-I-N-D" and "C-O-L-D." Just when Rocket looks the most downcast, we watch the snow "M-E-L-T" and know that spring will soon return and the little yellow bird with it. The pup sees the bird's chalkboard with the message "Class starts tomorrow," and spells "W-A-G" as he happily awaits his friend and instructor. All of the words are simple enough for beginning readers to sound out for themselves. And of course the tale of Buster, "the lucky dog who found his bone under the lilac bush," is one that Rocket and his yellow-feathered teacher read "again. And again. And A-G-A-I-N." Together Rocket and the little yellow bird reveal a magical world that reading opens up for all of us.


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Objectives and scope
The objective of the project is to increase the consumption of Canarian products in the tourism sector (hotels, restaurants and distribution) based on a consensual and collaborative strategy, beneficial to all the agents involved through the VOLCANIC Xperience brand.
Link the image of the Canary Islands to its products and its gastronomy, identifying them as another value of the holiday destination.
Increase the demand for Canarian products among visitors.
Increase the consumption of Canarian products in hotels.
Generate synergies with the tourism sector that allow diversifying the Canarian economy by increasing the weight of the primary sector.


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In the northern part of Istria is located one of the most famous and most attractive Istrian towns – Motovun, which dates back to the Middle Ages, and stands out as a familiar symbol of the Istrian inland.
Motovun has long been regarded as an attractive and popular tourist destination where you can visit many historical buildings, dominated by the Romanesque-Gothic bell tower from the 13th century which is located next to the St. Stephen 's Church from the 17th century. In the main square there is a Romanesque Municipal Palace, which is the largest secular building from this period in Istria, and the Hotel Kastel is located in the former palace of the family Polesini. In Motovun, ther are a number of events held each year , the most popular being the international "Motovun Film Festival". This film festival is held in late July with the participating film artists from around the world. There are also several hot balloon events, due to its favorable micro-climate that allows flying (balloon) throughout the year. Motovun is the most famous white truffles location in the Motovun forest, which is located along the valley of the river Mirna. Istrian truffles are known as aphrodisiacs, and their season runs from September to January.
Opposite Motovun is the town of Oprtalj where traditionally from September to November "Days of truffles" are held. Motovun is also famous for its vineyards, the most popular varieties of wine are red Teran and the white Malvasia. In the surrounding area there are taverns and restaurants with rich gastronomic offer.


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The opioid crisis. TV addicts. A road trip in a Chevy Cruze. A talking gun. These might not be the first things that come to mind when considering a modern-day retelling of Cervantes' Don Quixote. But in Salman Rushdie's 15th novel Quichotte (pronounced key-shot) those are just a few of the many things to make an appearance.
In the original book, Don Quixote's brain was addled by reading too many romances — and so he decides to become a knight-errant and head out to revive chivalry and save his country accompanied by his level-headed sidekick, Sancho. In Rushdie's retelling, crime-thriller writer Sam duChamp decides to create a new character: Ismael Smile, whose brain has been addled by watching too much TV, renames himself Quichotte and sets out on a quest to find his true love, the TV personality Salma R.
Like his namesake, he is looking for love and redemption in an America that might seem as if it is beyond either. Rushdie spoke to the Star about the book, being nominated yet again for the Booker Prize, and how he lost his own sister to the opioid crisis.
Both you and Margaret Atwood, previous Booker Prize winners, are shortlisted for it again this year, you for Quichotte and her for The Testaments.
We have actually been having some fun about the old folks at the party. I just emailed her to congratulate her and to say I looked forward to seeing her there. And she wrote back a sort of funny Peggy Atwood letter about how we were there as the old codgers, but we're still not too old to have a dance.
Do prizes matter much to you these days?
It doesn't matter in an ego sense, but what I respect about the Booker Prize is that it helps many people find their way to your book. And anything that does that I'm in favour of. Its impact has become so great now that I think the only person who doesn't need the Booker this year is Margaret Atwood, because she's going to sell a billion copies anyway.
On one level, this new book, Quichotte is a good old American road trip story.
My previous novel, The Golden House took place 95 per cent on Manhattan Island. And I remember when I finished it, saying to myself, 'OK, now you need to leave town.' America is a big place. And it's not all about New York. It's really about trying to get a bit of a panorama of this enormous country with all its difficulties, but also its beauties.
What made you think retelling the Don Quixote story would be a good gateway to the rest of America?
What I like about Cervantes' great book is first of all the relationship between Quixote and Sancho. Quixote has his head in the clouds. Sancho has his feet on the ground. Quixote is a dreamer. Sancho is a realist. But I found my characters developing a little differently. Where Don Quixote is melancholy, mine is relentlessly cheerful and optimistic. And I thought there was something interesting about taking a character who's full of hope, and full of optimism, and dreaming impossible things, and sending that character across a country which may not be at its most optimistic moment, to put it mildly.
There are a few incidents in the book where the difficulty of what it's like to be travelling while brown or Black in America comes up.
I thought if I'm going to send these two people in their battered Chevy Cruze across Middle America, I can't pretend that racism doesn't exist. I have to incorporate it. I don't want the book to be preachy, but I can't ignore the fact that they certainly would encounter some kind of hostility. It's every day in America right now.
Is he a standard for what America aspires to be?
I don't want him interpreted in that simple allegorical way. I don't think he represents the American dream. It's so nice to have a central character who is not broken by events but who believes against all odds, in goodness. Quichotte believes that in order to win the lady's hand he has to become worthy of her, he has to improve himself. In a moment of American culture which is darker it allows me to be funny.
The lists of TV shows, pop-culture references and news headlines in this book is dizzying. How much TV do you watch, anyway? I can't quite picture you sitting there with the channel changer flicking between shows.
Until I had the idea of writing this book about this man who's deranged by television, I didn't really watch that much. But then I thought, I can't write this book without knowing what he's watching. So, I had do my due diligence, watch my Bachelors, Bachelorettes, Project Runways, Real Housewives of various cities. I did plunge into it. And now I don't have to.
And what were your thoughts?
I thought 'if I watch this for any time then I'd be the one that was deranged.' It convinced me that what I proposed about the character was literally true. And one of the things about him, which is expressed by him watching all this TV, he's very lonely. He has no love in his life, he has never been married, he has no children. So he sits in these motel rooms in the Midwest and he watches television. I think one of the things that can happen to people who watch enormous amounts of television is that they begin to feel that they know the people on the other side of the screen.
One major character in the book is Quichotte's nephew, who owns the big pharma firm for which his uncle initially works.
A couple of people who were close to me actually died as a result of opioid abuse, including my youngest sister who died in 2007, so it's been 12 years. She was only 45. That made it personal to me. And as a result, I began to dig into this stuff, asking people for advice and finding books to read and following journalists covering the field, and so on. It's only now that I feel as if we're ready to talk about it.
The big pharma firms have an awful lot to answer for.
We've just seen Johnson and Johnson have been very heavily fined. I'm glad that finally these big pharma companies are being held accountable for this crisis. But one of the things that I was really shocked by was the ease with which it was possible to corrupt members of the medical profession. For modest sums like $20,000, $30,000, some become willing to prescribe these very dangerous drugs.
There are mentions in the book of India, America and England, and how these countries are broken.
In all three cases, people are being asked to believe in a fictional, mythologized version of the glorious past in order for the people propagating that theory to gain power. In America there's that red hat. Whenever I see that red hat I want to ask the people wearing it: When exactly was America great? And similarly, in England, the whole Brexit nonsense is driven by a myth of England, that there was this golden age before there were any inconvenient foreigners. In each of the three countries there's a golden-age myth which has been used to drive contemporary populist xenophobic politics.
We are a world divided in some sense, families having travelled to different corners of the earth. Does that mean we can't understand the places we came from?
In this moment of migration ... it's become a normal part of the human condition that there should be these distances between us. I was very conscious as a young man when I was living in England, of the danger of losing touch with my origins. Writing Midnight's Children was for me a kind of reclamation: this is where I come from, this is who I am. I was (recently asked) what advice would I give to young people of Indian, Pakistani, Bangladeshi descent living in England. And I said: don't lose touch. Try not to lose the language. Because if you retain the language, you retain access to the culture.
There's a bit in the beginning of the book: "Brother ... was possessed of the fool's conviction that the imaginings of creative people could ... enter and transform and even improve the real world." That seems to me to be saying that art can change the world.
I don't think many revolutions are started by artists. But I do think that great art can be a mirror, which reveals meaning. And I think, the experience of loving a book, when the vision of that book in part becomes your vision, and you begin to see the world through the eyes of that book, I think that's how they change people; you love the book and therefore you begin to see like it.
And, ergo, love can change the world.
Ergo love can change the world. Love will find a way, as Quichotte keeps telling us. Love will find a way.


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I assume because life is connected to these outlooks & the future of earth or countries would depend on it. There would be always two kind of people, Liberal or conservative. Some times it's crucial that how many % of people in a community take one of these sides. For instance, a country like India, only few big cities progressed & accepted technology & being connected to outside world & new things, but most of the country is going by tradition for example in so many villages when they get poisons by snakes which is common, they don't accept medicals & medicines, they do attempt for healing on their own with their tradition ways.
So the discussion & kind of battle of liberal & conservative in bigger views will exist cause any changes would decide the future lifestyle in so many aspects for both sides. That might be the reason people get into it a lot.


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Effect of Scaleup and Aggregation on the Analysis of Interference Tests
- Authors
- Rajagopal Raghavan (Phillips Petroleum Co.) | Ralph R. Roesler (Southwestern Energy Co.) | O. Inanc Tureyen (Stanford U.)
- https://doi.org/10.2118/84291-PA
- Document ID
- Publisher
- Society of Petroleum Engineers
- Source
- SPE Reservoir Evaluation & Engineering
- Volume
- 7
- Issue
- 06
- Publication Date
- December 2004
- Document Type
- Journal Paper
- Pages
- 392 - 398
- Language
- English
- 1094-6470
- Copyright
- 2004. Society of Petroleum Engineers
- Disciplines
- 5.5.8 History Matching, 2.2.2 Perforating, 5.1.5 Geologic Modeling, 5.6.9 Production Forecasting, 5.1 Reservoir Characterisation, 5.7.3 Deterministic Methods, 4.1.2 Separation and Treating, 5.6.4 Drillstem/Well Testing, 5.6.3 Deterministic Methods, 4.3.4 Scale, 5.5 Reservoir Simulation, 5.1.2 Faults and Fracture Characterisation, 5.6.5 Tracers, 4.1.5 Processing Equipment, 5.1.1 Exploration, Development, Structural Geology, 5.2 Reservoir Fluid Dynamics
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The objective of this paper is to demonstrate the influence of detailed, small-scale heterogeneities on interference tests. Specific issues encountered when interference tests are analyzed in reservoirs with complex geological properties are discussed. These issues relate to questions concerning the use of low-resolution models, the degree of aggregation, the methodology of scaleup, and the reliability of conventional methods of analysis.
This paper demonstrates the importance of capturing fine-scale heterogeneities to replicate the true transient behavior of interference tests at both active and observation wells. The paper shows the effects of aggregation and scaleup as used routinely in the industry on evaluating transient responses. The consequences of using low-resolution models in systems with complex geology is also demonstrated. If low-resolution models are used, reservoir properties may be adjusted unrealistically to match the transient behavior observed in high-resolution models. Though scaleup preserves pore volume, estimates of storativity predicted by low-resolution models will have a significant effect on reservoir behavior and resource management. If porosity values are not regressed, significant changes in vertical permeability values are observed. This is an important observation with potentially dramatic effects on reservoir performance, especially in processes involving mobility differences. Regression on a single-layer model (homogeneous, or based on aggregation) was also shown to yield totally different geological outcomes. This also shows the need to use geological constraints during inversion, aggregation, and scaleup.
This work provides guidelines concerning the evaluation of interference or pulse tests in reservoirs with complex geology. In the process, the paper demonstrates the role of small-scale heterogeneities on the responses of interference tests and how those heterogeneities may affect the analysis of a test. In the past, it has been suggested that interference and pulse tests provide a better measure of reservoir heterogeneity.1 Our work also permits us to examine the consequences of working with a low vertical resolution, as is normally done in most analyses. It is important to recognize the choice of this kind of model because the consequences of such a choice have a significant bearing on the spatial and petrophysical relationships we wish to determine. The importance of not ignoring the vertical resolution is demonstrated. The choice we make regarding the scale at which we analyze data influences the characteristics of the model we use to describe the reservoir; this choice, in turn, will have a significant bearing on our evaluation of fluid movement in injection/production schemes. In doing so, we also illustrate the consequences of aggregation and scaleup. The results of this study were obtained by the model given in Christie and Blunt2 because it provides information on a very fine scale and is thus particularly suited to meet the goals of this study.
Literature Review
The issue of heterogeneity as it relates to well performance and pressure tests may be traced to Cardwell and Parsons.3 Using deterministic methods, these authors considered steady, radial flow to a well in a reservoir in the form of a circle and showed that the equivalent transmissivity, Teq(khµ), is bounded by the volume-weighted arithmetic and harmonic means. The earliest work on statistical methods that is most often quoted is that of Warren and Price.4 On the basis of numerical experiments of pressure-buildup tests, they concluded that a porous medium that is assumed to consist of a quilt or patchwork of porous elements that are randomly distributed in 3D may be represented by a porous rock with a permeability equal to the geometric mean of the permeability of the individual elements. Although Warren and Price4 do not specifically recognize that the properties of rocks are usually correlated, at least weakly, on all scales, it has been shown that the effective permeability, keq , of a 2D system under the assumption that the porous body is a log-normal, subisotropic and ergodic medium is equal to the geometric mean of the permeability of the individual elements. For 3D systems, however, their result is only approximately correct.5 Technically, one should expect the equivalent permeability to be tensor.6
To better represent conditions in groundwater testing, Vandenberg7 conducted a series of evaluations of interference tests in a manner analogous to that of Warren and Price and concluded that interference tests in heterogeneous formations analyzed by the Theis8 method appear to yield transmissivity, T, estimates that reflect the arithmetic mean of the individual elements of the heterogeneous porous medium. Estimates of storativity, S(fcth), varied over a much wider range than estimates of T. Similar observations are made in reports by Herweijer and Young,9 Schad and Teutsch,10 and Meier et al.11 These studies are essentially restricted to 2D systems. The information in Refs. 8 through 11 also indicates that transmissivity estimates appear to depend primarily on the distance between the pumping and observation wells and may be reasonably constant (all other things being equal); however, the variation in the estimate of storativity, S, is quite significant. It is to be noted that the variations in the estimates of S are not the result of fitting the measured drawdowns to the Theis solution or to its asymptotic (semilog) approximation given by Jacob.12 The observation of these authors that T is reasonably constant may be understood by the results given in Oliver.13,14 Large variations in the estimate of S, however, are not a surprising result. As will be shown here, this result is a direct consequence of analyzing the well responses in a heterogeneous system by a homogeneous model. In particular, if interference responses are analyzed by the method of Theis,7 then any property of the reservoir involving the distance variable will usually be in significant error.15,16 Also, when interference tests in heterogeneous systems are analyzed in the conventional way, one must at least consider anisotropy (in magnitude and azimuth) and if rigor is to be reflected in the analysis, the possibility that the estimate of transmissivity reflects a tensor must be recognized. If no such recognition is made, then estimates of S may not be representative for significant variations in S obtained even in relatively homogeneous but anisotropic reservoirs whenever reservoir anisotropy is ignored; see Ramey.17
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A handful of notable new releases out today, at the top of my personal anticipation list is the new album from SoCal rockers Rival Sons "Hollow Bones". Also, you can find new albums from the quadruple guitar attack of Diarrhea Planet on "Turn to Gold", alt-rock/country stalwarts Band of Horses with "Why Are You OK", […]
Tag Archives: review blog
Winter by TV on the Radio
Winter highlights some big guitar sound from Malone as the track starts off. The first minute is just Malone's guitar and Adebimpe's vocals, until a simple drum beat kicks in with some heavy underlying bass. The underlying elements sound simple, but as the song evolves it sounds much bigger than its parts. […]
Rainbows and Butterflies by Wussy
Rainbows and Butterflies features Cleaver on lead vocals and showcases one of their "louder" cuts. I'm attaching a live performance because it's not that easy to find just audio clips on YouTube. And the live on KEXP clips are generally great to watch anyway. live performance on KEXP
Teenage Wasteland by Wussy
Teenage Wasteland features nice vocals from Walker, sung with just the right amount of inflection and emotion. The clip from YouTube is not unfortunately not pristine, but you can still get the gist.
Jealous Sun by The Horrors
"Jealous Sun" is a little more trippy than "So Now You Know", featuring some swirling keyboards that provide some interesting atmosphere throughout the track. Again, you have a steady beat and prominent bass that helps keep the song moving along through the hazy atmosphere the rest of the instruments are creating.
So Now You Know by The Horrors
"So Now You Know" features very leisurely verses that morph into more bombastic choruses. It's the type of track that could have definitely earned more radio play. The track also has some nice musical interludes, highlighting the gauzy guitar sound the band uses quite often, along with some prominent bass.
The Horrors
The Horrors released their 4th album "Luminous" midway through last year, and I've been meaning to include them in this email ever since. The band formed in 2005 in London, released singles and an E.P. over the next few years until their debut album "Strange House" came out in '07. The band was more punk […]
Champagne Kisses by Jessie Ware
Champagne Kisses has some flashier production than some of the other tracks, and also features a falsetto by Ware that isn't heard very often. The bass is a little heavier on this track as well, and it has a bigger "poppy" chorus that sticks in your mind. However, there are still many subtle touches throughout […]
Kind Of…Sometimes…Maybe by Jessie Ware
Kind Of…Sometimes…Maybe is a slow burner, heavy on the atmosphere. As you may have guessed, the title of the song is also the chorus. There are subtle production techniques throughout, and they percolate just under the surface so you have to be paying attention in order to notice them fully. This track is a good […]
What by Broncho
What leads off the album and is a good example of the band's sound. Nothing too in your face, but there's plenty of interesting elements going on. Effective guitar work, but nothing flashy. Some interesting vocal tics, mostly coming out in the chorus. It's a short track at just over 2 minutes so it's over […]


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Crimean War museum will be opened in Eupatoria /PHOTO/
|10:23 19.09.2012
|Читати українською
The museum will be located on Revolution street, 61. Preparations are now under way to repair the premises of the future museum, works are funded from the city budget.
Draft of exhibition halls' decoration is under development, the City Council press service
One of the museum exhibits will be a replica of the Crimean War ship «Henry IV» - the largest
warship which came to Eupatoria to disembark the allied troops.
Photo by Eupatoria City Council press-centre
The ship's replica will be part of the wall of one of the museum's halls. It is being crafted
by artists of the Gromovs studio. They recreate the military vessel by old photographs and
descriptions. The replica is being crafted out of armoured concrete and plaster cast. It will be
decorated with wooden parts and real sails. The work is planned to be finished this week, and the
museum will open in October.
Electrified relief colour map of the war will be installed in the museum.


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to Journey
We are a Christian wilderness ministry based out of Colorado's Arkansas River Valley. We offer customized, Christ-centered wilderness adventures for youth, families, and groups. Our exciting and purposeful activities include whitewater rafting, rock climbing, backpacking, mountaineering and more. Our goal is to glorify God while sharing the hope of His Gospel with all who come on our trips, keeping Jesus Christ at the focal point of our ministry. With exciting daily Whitewater Rafting Adventures and amazing Multi-Day Trips, you're sure to find a trip that is perfect for your family or group!
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The River
"Come to me all who labor and are heavy laden, and I will give you REST" (Matt 11:28) The river. I'm reminded today how much it is like life. It's always flowing. It never moves backwards. It's unpredictable. It has Obstacles. It creates joy and fear. It's amazing and...read more
Living in a Fishbowl
Guiding on the Arkansas River is an entirely engaging experience. When one is paddling through a rapid, all the focus is on the water straight ahead. As a guide, my viewpoint has been from the river. I immerse myself in each trip by talking with my guests and...read more
Be Still
What does it mean to be still and know that He is God? What does being still in his presence mean? What does it mean to know God? When I think about getting to know someone, I imagine conversations, activities done together, and places seen together.read more


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We examined the effect of p53 inactivation on the response of U87MG glioma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). These studies were motivated by three observations: (a) some human astrocytomas are sensitive to BCNU and some are resistant; (b) chemosensitive astrocytomas are more likely to be found in young adults whose tumors are more likely to harbor a p53 mutation; and (c) mouse astrocytes lacking the p53 gene are more sensitive to BCNU than wild-type cells. Here, we observed that p53 inactivation by transfection with pCMV-E6 sensitized U87MG cells to BCNU. Compared with control U87MG-neo cells with intact p53 function, the clonogenic survival of U87MG-E6 cells exposed to BCNU was reduced significantly. In U87MG-E6 cells, sensitization to BCNU was associated with failure of p21WAF1 induction, transient cell cycle arrest in S phase, accumulation of polyploid cells, and significant cell death. In contrast, resistance to BCNU in U87MG-neo cells was associated with up-regulation of p53, prolonged induction of p21WAF1, sustained cell cycle arrest in S phase, and enhancement of DNA repair. U87MG cells with disrupted p53 function were less able to repair BCNU-induced DNA damage and survive this chemotherapeutic insult. The question arises of whether p53 dysfunction might be a chemosensitizing genetic alteration in human astrocytic gliomas.
Two distinct molecular pathways may be activated by p53 in response to DNA damage. p53 may trigger programmed cell death, but it may also set into motion mechanisms that facilitate cell survival. Ultimately, the balance between these opposing responses to injury, which may be both cell type and insult specific, determines cell fate (1 , 2) . In the context of neoplasia and chemotherapy, the influence of p53 function on response to treatment is doubly complex because p53 often is inactivated in human cancers (3) . For example, p53 might contribute to sensitivity if tumor cells apoptose following drug treatment (4) or to resistance if therapeutic DNA damage is repaired preferentially (5) . Conversely, in a cell harboring a mutation, p53 inactivation might contribute to resistance if tumor cells are unable to apoptose or to sensitivity if checkpoint failure leads to ineffective DNA repair. At present, the influence of p53 status on chemosensitivity is unknown for many types of human cancer. In neuro-oncology, there is circumstantial evidence suggesting that the response of astrocytic gliomas to BCNU 3 may be linked to p53 status. Clinicians have noted that chemosensitive tumors are more likely to be found in young adults whose astrocytomas are also more likely to harbor a p53 mutation (6) . In related research, it has been observed that neonatal mouse astrocytes lacking the p53 gene are more sensitive to BCNU than wild-type astrocytes (7) , whereas p53 knockout fibroblasts (7) and thymocytes 4 are more resistant to BCNU than wild-type cells, indicating cell type-specific p53 effects. Furthermore, these findings suggest that induction of p53 preferentially activates mechanisms that enhance the survival of cells of astrocytic derivation. In this study, we examined the influence of p53 disruption on the viability of human astrocytic glioma cells exposed to BCNU.
Cell Lines and Drug Sensitivity Assay.
U87MG, a human glioma cell line with functional wild-type p53 (8) , was purchased from the American Type Culture Collection (Rockville, MD). U87MG and derivative cell lines were maintained in antibiotic-free MEM (Life Technologies, Inc.) supplemented with 10% fetal bovine serum and 1 mm sodium pyruvate. To generate a glioma cell line lacking p53 function, U87MG was transfected with pCMV-E6; the human papillomavirus E6 gene encodes a protein that binds to and inactivates p53. To serve as a control, U87MG was also transfected with pCMV-neo, a plasmid lacking the E6 gene. pCMV-E6 and pCMV-neo plasmid DNAs were provided by Dr. K. Cho (University of Michigan, Ann Arbor, MI) (9) . pG13-CAT plasmid DNA was provided by Dr. B. Vogelstein (Johns Hopkins Cancer Center, Baltimore, MD) (10) . Plasmids were transformed and amplified in competent bacteria DH-5α (Life Technologies), and DNA was isolated using the EndoFree plasmid kit (Qiagen) according to the manufacturer's instructions. Transfections were performed using a calcium phosphate reagent kit (Life Technologies). After incubation in medium containing 400 μg/ml G418 (Life Technologies), individual U87MG clones were isolated and tested for endogenous wild-type p53 activity (see below).
BCNU (Mr 214.06) was purchased from Bristol-Myers Pharmaceuticals. A stock solution was prepared by dissolving 100 mg of BCNU in 30 ml of 10% ethanol, and was stored at −70°C to ensure drug stability (12) . Subsequently, BCNU stock solution was added directly to culture medium to achieve the desired concentrations for experimental use.
To ascertain sensitivity to BCNU, clonogenic survival assays were performed. Clonogenic assays, more reliably than others, assess whether tumor cells survive and proliferate following drug treatment (11) . U87MG-E6 cells (p53 inactivated) and U87MG-neo cells (functional p53) were plated at low density in 100-mm dishes and exposed to BCNU. Cultures were incubated for 2–3 weeks without a change in medium. Colonies were then fixed, stained with 1% crystal violet in methanol, and counted.
Function and Induction Studies.
p53 function in U87MG-E6 and U87MG-neo cells was assessed using a CAT enzyme assay system (Promega). Briefly, cultures were transfected with pG13-CAT, a plasmid containing wild-type p53-responsive elements, washed with PBS, and lysed in 1× Reporter Lysis Buffer. As a control for transfection efficiency, 0.5 μg of pSV-β-galactosidase plasmid was cotransfected and β-galactosidase activity was measured using an enzyme assay system (Promega). CAT activity was determined on lysates with equal β-galactosidase activity using [14C]chloramphenicol and TLC or liquid scintillation counting. CAT activity was quantified using a PhosphoImager (Molecular Dynamics) or measured on a scintillation counter. CAT activity was expressed as the percentage of conversion of [14C]chloramphenicol to butyrylated forms and was normalized to control activity, which was set at 100%.
p53, p21WAF1, and MGMT expression was assessed by Western blotting in U87MG, U87MG-E6, and U87MG-neo cells in response to BCNU treatment. Cultures were washed twice with PBS, lysed in preheated SDS buffer (1% SDS-5% glycerol), heated to 100°C for 5 min, and stored at −20°C. Protein concentrations were determined using a DC Protein Assay kit (Bio-Rad). Subsequently, lysates were supplemented with 100 mm DTT, heated to 100°C for 5 min, loaded on precast 8–16% gradient SDS-PAGE gels (Novex), and transferred to nitrocellulose membranes in a semi-dry gel transfer module (Novex). Hybridization to antibodies was performed, and signals were visualized using an enhanced chemiluminescence kit (Amersham). Blots were stained to ensure equal protein loading. Antibodies to p53 and p21WAF1 were obtained from Santa Cruz Biotechnology, and antibodies to MGMT were obtained from PharMingen.
Cell Cycle and Death Analyses.
Approximately 1 × 106 U87MG-E6 and U87MG-neo cells were seeded in 150-mm Petri dishes. Forty-eight h later, cultures were treated with identical concentrations of BCNU. After incubation, suspensions of single nuclei were prepared and stained with propidium iodide as instructed, using a Cycle TEST PLUS DNA reagent kit (Becton & Dickinson). Cells (1 × 106) were analyzed on a Beckman Coulter XL-MCL instrument using the FL3 detector with 620 nm band-pass filter. For each sample, 50,000 events were collected. Analyses of the data were performed on ungated histograms by use of MultiCycle software (Phoenix Flow System). For control samples, a zero-order polynomial fit with background subtraction was used. For complex cell cycle histograms, a synchronized S-phase model with a second-order polynomial and background subtraction was used. In addition to measuring sub-G1 DNA contents by flow cytometry, we evaluated cell death by assessing DNA fragmentation of U87MG-E6 and -neo cells exposed to BCNU using both DNA ladder and TdT-mediated dUTP nick end labeling (Roche) methods according to the manufacturer's instructions.
DNA Repair Assay.
DNA repair capacity in U87MG transfectants exposed to BCNU was assessed using a host cell reactivation assay. In this assay, host cells were transfected with a damaged CAT reporter plasmid and then exposed to an active drug or sham treatment. Repair of the plasmid as reflected by CAT activity was then a measure of repair capacity in the host cell (5 , 13) . Briefly, 2 μg of reporter plasmid DNA pCAT3 (Promega) was incubated with 2 mm BCNU in 20 μl of culture medium (pH 7.5) at 37°C for 2 h. BCNU-damaged plasmid DNA was diluted into 100 μl of Opti-MEM medium (Life Technologies) and mixed with an equal volume of Opti-MEM containing 20 μg of Lipofectin reagent (Life Technologies). The DNA-lipofectin complex was added to exponentially growing U87MG-E6 or U87MG-neo cells seeded 48 h earlier. Immediately prior to transfection, culture medium was replaced with 5 ml of Opti-MEM. As a control for transfection efficiency, 0.5 μg of pSV-β-galactosidase plasmid was cotransfected. After overnight incubation and the addition of fresh medium, each culture that had been transiently transfected with BCNU-damaged plasmid DNAs was treated with BCNU or sham treated. BCNU solution (5 mg/ml in 10% ethanol) or 10% ethanol (sham) was added to a concentration of 15 μg/ml or 0.03%, respectively. BCNU- and sham-treated cultures were incubated for 48 h without a change in medium followed by CAT and β-galactosidase assays. CAT activity was measured by liquid scintillation counting and normalized to β-galactosidase activity (internal control). CAT activities of transfected U87MG-E6 and U87MG-neo cells exposed to BCNU were normalized to sham-treated U87MG-E6 and -neo cultures, respectively, which were set at 100%.
Clonogenic Survival Assay.
Following transfection with pCMV-E6, p53 function was assessed in multiple clonal cell lines. Six cell lines in which p53 had been successfully inactivated by E6 were subjected to further analysis; in all clones tested, inactivation of p53 resulted in sensitization to BCNU. BCNU-treated U87MG-E6 cells had significantly reduced clonogenic survival compared with either U87MG-neo or U87MG parental glioma cells (Fig. 1) ⇓ . In addition, the LD50 for U87MG-E6 cells was half that of either U87MG-neo or U87MG parental cells, whose LD50s were similar (Fig. 1) ⇓ . These results parallel our earlier findings with neonatal mouse astrocytes; in those studies, astrocytes lacking the p53 gene were significantly more sensitive to BCNU than wild-type astrocytes (7) .
p53 and p21WAF1 Induction Studies.
p53 and p21WAF1 expression was evaluated in U87MG-E6 and -neo cells. As shown in Fig. 2 ⇓ , lower levels of p53 protein were detected in the U87MG-E6 cells in which p53 function had been inactivated. U87MG-E6 cells had markedly diminished p53 activity, as assessed by CAT assay, compared with both U87MG-neo and U87MG parental cells (Fig. 2) ⇓ . In contrast, p53 protein was readily detected in U87MG-neo cells, and protein levels in U87MG-neo cells, but not in U87MG-E6 cells, increased significantly in response to BCNU treatment (Fig. 2) ⇓ . Increased p53 protein levels could be detected as early as 12 h following exposure to 30 μg/ml BCNU and increased 4-fold over basal levels by 24 h. In light of the induction of p53 by BCNU in U87MG-neo cells, the expression of p21WAF1, an important downstream target for p53 (14) , was examined in U87MG-neo cells. Forty-eight h after exposure to BCNU, levels of p21WAF1 had increased dramatically in U87MG-neo cells and remained markedly elevated for an additional 48 h (Fig. 2) ⇓ . In contrast, p21WAF1 could neither be detected nor induced by BCNU in U87MG-E6 cells.
Cell Cycle Distribution in U87MG-E6 Cells after BCNU Exposure.
Given the absence of p21WAF1 in U87MG-E6 cells and the role of p21WAF1 in cell cycle regulation, we evaluated the cell cycle distributions of U87MG-E6 and U87MG-neo cells in response to BCNU treatment. As shown in Fig. 3 ⇓ , 30 h after exposure there was a dramatic increase in S-phase populations in both U87MG-E6 and U87MG-neo cells compared with sham-treated controls. Ninety-six h after exposure to BCNU, the G2-M phase population had increased substantially in U87MG-E6 cells, whereas U87MG-neo cells with intact p53 function remained arrested in S phase (Fig. 3) ⇓ . Moreover, at 96 h, 20–40% of U87MG-E6 cells had polyploid nuclei with a DNA content of 8n. In addition, there was a substantially larger sub-G1 fraction in U87MG-E6 cells after BCNU exposure, indicating greater cell death in the absence of p53 function (Fig. 3) ⇓ . Although the precise mechanism of enhanced killing of E6 cells remains to be elucidated, exposure to BCNU did not appear to trigger substantial programmed cell death in either U87MG-E6 or -neo cells. Low molecular weight DNA ladders were not detected in either U87MG-E6 or -neo cells exposed to BCNU (data not shown). Moreover, after BCNU treatment, TdT-mediated dUTP nick end labeling was observed in <10% of both U87MG-E6 and -neo cells (data not shown).
Decreased DNA Repair in p53-inactivated U87MG-E6 Cells.
A host cell reactivation assay was used to assess DNA repair capability in U87MG-E6 and -neo cells. Prolonged induction of p21WAF1 in U87MG-neo cells by BCNU, and a report of enhanced repair of BCNU-induced DNA damage in glioma cells overexpressing p21WAF1 (13) , suggested that the relative resistance of U87MG-neo cells to BCNU might be explained by more effective DNA repair in the presence of intact p53 function. Relative to sham-treated cells, CAT activity increased by 50% in BCNU-treated U87MG-neo cells (Fig. 4) ⇓ . In U87MG-E6 cells, however, CAT activity after BCNU exposure decreased slightly compared with sham-treated cells (Fig. 4) ⇓ . Hence, following exposure to BCNU, enhanced DNA repair occurred in U87MG-neo cells with intact p53 function, whereas U87MG-E6 cells with disrupted p53 function were unable to augment DNA repair following such treatment. Although the specific mechanism by which DNA repair is enhanced in U87MG-neo cells is unknown at present, repair enhancement was not explained by up-regulation of MGMT, a suicide DNA repair protein whose activity has been implicated in BCNU resistance (15) ; in keeping with a previous report (16) , neither MGMT mRNA nor protein were detectable in U87MG cells (data not shown).
In this study, we demonstrate that inactivation of p53 by E6 sensitizes the human astrocytic glioma cell line U87MG to BCNU, the drug of choice for patients with anaplastic astrocytoma and glioblastoma multiforme. Furthermore, sensitization of U87MG-E6 to BCNU is associated with a failure of p21WAF1 induction, transient cell cycle arrest, accumulation of polyploid glioma cells, and significant cell death. These findings are congruent with those of Waldman et al. (17) , who reported that treatment with anticancer drugs in cells with inactivated p21WAF1 could lead to failure of cell cycle arrest, repetitive abnormal mitoses, and the accumulation of polyploid cells, which then apoptose. In contrast to U87MG-E6, resistance to BCNU in U87MG-neo cells with intact p53 function was associated with up-regulation of p53, prolonged induction of p21WAF1, sustained cell cycle arrest, and significant enhancement of DNA repair. These findings and those of Nutt et al. (7) in mouse astrocytes suggest that DNA repair, not programmed cell death, is the principal consequence of p53 induction in both normal and neoplastic astrocytic cells and raise the further possibility that DNA repair in response to injury is a fundamental property of astrocytes, a cell type with barrier and detoxification functions in the mammalian central nervous system (18) .
Following exposure to BCNU, both U87MG-E6 and U87MG-neo cells arrested in S phase. Although unusual, S-phase arrest has been reported previously in some types of cells after exposure to specific cytotoxic drugs. Bunch and Eastman (19) , for example, observed that Chinese hamster ovary cells treated with cisplatin arrested in S phase. Following abrogation of S-phase arrest, Chinese hamster ovary cells progressed to G2 and, subsequently, to apoptotic cell death. S-phase arrest in U87MG glioma cells occurred in two steps. The initial step, which appeared promptly in both U87MG-E6 and U87MG-neo cells, was p53 independent. The second step, sustained arrest in S phase, occurred only in U87MG-neo cells with functional wild-type p53. Sustained arrest was associated with a 3.5-fold induction of p53 and a 10-fold induction of p21WAF1; moreover, p21WAF1 induction in U87MG-neo cells was prolonged. In U87MG-E6 cells, however, S-phase arrest was transitory and followed by progression to G2-M. Hence, the relative resistance of U87MG-neo cells to BCNU would appear to be explained by the combined influences of sustained cell cycle arrest and DNA repair enhancement. Conversely, the relative chemosensitivity of U87MG-E6 cells would appear to be attributable to the combined effects of cell cycle checkpoint failure and insufficient DNA repair capacity. Conceptually, our findings are in keeping with those of Bunz et al. (20) , who observed that p53 and p21WAF1 together are required for sustained cell cycle arrest (in G2) following DNA damage, and also consistent with the observations of Agami and Bernards (21) , who noted that distinct initiation and maintenance mechanisms cooperate to induce cell cycle arrest (in G1) in response to injury.
Future studies will determine whether p53 inactivation is similarly chemosensitizing when U87MG glioma cells are grown in vivo and explore whether p53 disruption renders U87MG sensitive to many types of chemotherapeutic agents, to certain classes of cytotoxic drugs only, or only to BCNU. It will also be important to ascertain whether sensitization to BCNU following inactivation of p53 is a feature unique to the human glioma, U87MG, or a property characteristic of astrocytic glioma cells, i.e., whether other human astrocytic cell lines with functional wild-type p53 are also sensitized to BCNU when p53 is inactivated by E6 or by dominant-negative p53 mutant proteins. These studies are also necessary because other investigators who have examined the influence of p53 status on chemosensitivity in glioma cells have yet to discern a consistent effect or pattern (22, 23, 24) . To date, all investigations of p53 and drug response in glioma have occurred in vitro, and such analyses have limitations (11 , 25) . Observations in model systems, even those that appear relevant, require confirmation in the clinical setting. U87MG glioma cells resemble de novo glioblastoma (i.e., wild-type p53, PTEN mutation, p16 deletion), but molecular characterization of tumors that have responded, or not, to BCNU will be essential to a fuller appreciation of the molecular determinants of drug response in astrocytic neoplasms. Such studies will bring neuro-oncologists a step closer to rational drug selection for their patients.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
↵1 Supported by the Medical Oncology Research Fund at London Regional Cancer Centre, the Internal Research Fund at London Health Sciences Centre, and by the Canadian Institutes for Health Research (Grant 37849). Catherine L. Nutt was a Research Fellow of the National Cancer Institute of Canada.
↵2 To whom requests for reprints should be addressed, at London Regional Cancer Centre, 790 Commissioners Road East, London, Ontario, Canada N6A 4L6. E-mail: greg.cairncross{at}lrcc.on.ca
↵3 The abbreviations used are: BCNU, 1,3-bis(2-chloroethyl)-1-nitrosourea; CAT, chloramphenicol acetyl transferase; MGMT, O6-methylguanine-DNA methyltransferase.
↵4 M. C. Zlatescu and J. G. Cairncross, unpublished data.
- Received October 26, 2000.
- Accepted March 16, 2001.
- ©2001 American Association for Cancer Research.


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Job Type: Permanent full-time
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The Outside Sales Representative will develop, lead and be accountable for all aspects of sales for the business, while building and maintaining current relationships. Ideal candidate will have ten years of demonstrated sales/account management experience in the construction and rigging industries with a track record of success.
Company offers market-competitive compensation plans with a full range of benefits including medical/dental/vision, vacation and sick leave.
Territory: Boundaries are: Central Southern California out to Arizona and Nevada.
Bottom Line Requirements:1. 10+ years of sales experience in construction and rigging industries.


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Kel McBride, the Lively Death Lady, has put together a delightful list of euphemisms for death.
Anthony Martin, owner and CEO of Choice Mutual, authored today's guest blog post on "Three Myths About Burial Insurance." It's almost impossible for any industry to be completely devoid of inaccuracies and misinformation. The internet only… Read More→
How do you create a tangible object to remember a loved one, before that person dies? Here's an answer in today's guest post contributed by Laurel Lagoni. All too often, people are advised to put everything away that… Read More→
This guest blog post was written by Sarah Rickerd, founder and owner of Carry Your Heart Jewelry and Gifts. How do you say a good goodbye when you never said hello? On April 23, 2013,… Read More→
With the release of the new film Sully, about the airline pilot who safely landed a disabled jetliner on the Hudson River (the "Miracle on the Hudson"), it's a good time to consider being prepared for… Read More→
Did you know about the decomposition issues that can develop when you put a body in an above-ground mausoleum? We're talking about odorous gasses, leakage and crypt flies. The Doyenne of Death® gets some pretty… Read More→
Mary Carter, author of A Non-Swimmer Considers Her Mikvah: On Becoming Jewish After Fifty, wrote about the shock of learning about a death from an unexpected part of her personal history. This essay from the… Read More→


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Mermaids Dive Center Professional Staff
Sheena Walls
Sheena is also a PADI IDC Staff Instructor although most of her time is in the office. Sheena loves diving with her son.
Terry Wilkins
Terry is also General Manager as well as a PADI Course Director. He's most in his element in our dive equipment showroom.
Russell Martin
Russell is an award winning PADI Platinum Course Director and Tec Instructor Trainer. He loves Rugby and Chocolate.
Gordon Rimmer
Gordon is one of our lead Instructors and an amazing Specialty Dive Training Instructor. He loves a good slice of pizza.
Wayne Carr
Wayne is one of our lead instructors and is awesome with everyone with any course. He enjoys his PS4 and berry sweet bread.
Malai is the attention to detail and if you want it, she will find it. She loves socializing with her friends.
Nok is great with kids and all ages. Best person to find anything underwater, no matter how small. She loves animals.
Dtoo is our fun factor on the boats with her enthusiasm, she will make anyone laugh. Her daughter is her world.
Welcome to Mermaids Dive Center, PADI 5 Star Career Development Center. Since opening in the early 1990's, Mermaids have focused on Scuba Diving Education and training courses. Mermaids Dive Center was the first center in the Pattaya area of Thailand to be awarded with the PADI CDC (Career Development Center) status.
The PADI courses on offer from Mermaids are from entry level (non diver) courses through to PADI Professional Dive Courses such as PADI Divemaster or PADI Instructor. Based in Jomtien close to the Hanuman statue, we are the area's largest and best stocked retail shop.
We also offer divers accommodation and local travel arrangements for you. For traveling down from Bangkok, we offer a private car service at a reasonable price. Mermaids Dive Center operate full facilities with our own 3 private dive boats located in Pattaya and Samae San.
For the benefit of our students and divers alike you can dive with Mermaids Dive Center all year round.


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The ANAISE MAXI DRESS is a THE summer maxi, made of beautiful floral crepe pleated fabric. V-neckline with small ruffled cap sleeves. Crepe ribbon tie for the front or back for a dreamy touch and to cinch the waist for shape. Perfect for a day on the town or a special night out.
Pair this piece with sneakers or boots depending on your style.
- Maxi Dress
- V-Neck
- Cap Sleeves
- Zip at back
- Length: 60" center front length (size Medium)
- Model wearing size XS
- Model height: 5'8''
✨Sign up and receive 10% off your first order, receive exclusive access to new collections & special offers. ✨


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2019 Mercedes-Benz Sprinter Passenger Vans 49041
Dealership Information
1449 Greenleaf Blvd
Elkhart, IN 46514
Brand New Luxury Cruiser by Midwest Automotive Designs.
This vehicle is modified with US MADE Parts that conform all applicable US Federal Safety Standards. LG TV and Kenwood Double Din Receiver made in China. One year unlimited mileage warranty on conversion. 3-year/36K miles on Mercedes-Benz Sprinter Van Chassis.


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Farstad Announces 4Q 2010 Results (Norway)
Farstad Shipping achieved an operating income of NOK 905.3 million for the 4th quarter. The operating profit (EBIT) was NOK 203.9 million. The profit after taxes was NOK 39.5 million.
The operating income at 31.12.10 was NOK 3 358.2 million. The operating profit (EBIT) was NOK 899.3 million. The profit after taxes was NOK 431.8 million.
The Board will propose a dividend of NOK 4,00 per share for 2010.
Farstad Shipping's fleet currently consists of 58 vessels (32 AHTS, 24 PSV and 2 SUBSEA) and 4 PSV under construction. The company's operations are run from Aalesund, Aberdeen, Melbourne, Perth, Singapore, Macaé and Rio de Janeiro by a total of 1900 employees onshore and offshore. The company's strategy is to be a major international supplier of large, modern offshore service vessels to the oil industry.They also remain committed to solid long-term charter profile for the fleet.
1 million Norwegian kroner = 174 113 U.S. dollars
Source:Farstad, February 17, 2011;
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English Choose a language for shopping. Home Economics assessment as a practical subject. AmazonGlobal Ship Orders Internationally. Assessing home economics coursework in senior secondary schools in Botswana Leepile, Gosetsemang. Shopbop Designer Fashion Brands. Amazon Giveaway allows you to run promotional giveaways in order to create buzz, reward your audience, and attract new followers and customers.
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If you are a seller for this product, would you like to suggest updates through seller support? I'd like to read this book on Kindle Don't have a Kindle? Alexa Actionable Analytics for the Web. Amazon Music Stream millions of songs. The main research questions guiding this investigation were: This new certificate system, marked locally, allows for varied modes of assessment, with more emphasis being placed on continuous assessment.
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Create an Account - Increase your productivity, customize your experience, and engage in information you care about.
Due to COVID-19, the Utility Billing customer service window is closed until further notice.
Utility Payments - If you normally pay your bill at our customer service window, we strongly encourage you to pay your utility bill via credit card online (see links below). Online credit card payments are free to customers and can be set up as automatic recurring payments – set it and forget it! Alternatively, you can drop your payment in the overnight deposit box located on the South Rice Avenue side of City Hall. Customers paying by mail or set up on automatic credit card draft and automatic bank draft can continue to pay using these methods.
Trash Bags and Recycling Bins - Trash bag and recycling bin sales are suspended until the customer service window reopens. Store-bought trash bags can be used.
New or Terminating Service - If you need to start new service or terminate service, please call our Utility Billing customer service number at 713-662-8253.
For more information regarding the City of Bellaire and COVID-19, please follow this link: https://www.bellairetx.gov/CivicAlerts.aspx?AID=2200
Utility billing customer service processes the monthly utility bills and payments. Payments are due on the 2nd Friday of each month. Customers may contact a customer service representative to establish or disconnect service, inquire about their utility bill, inquire about service disruptions, report water leaks, and purchase garbage bags.


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AHRQ-Funded Projects
Current search
Search found 4 items
Enhancing Clinical Decision Support Applications for Community Pharmacist-Delivered Medication Therapy Management
This project will formulate evidence-based recommendations for clinical decision support used by community pharmacist delivering medication therapy management. The goal is to reduce medication-related problems and improve health outcomes for chronically ill patients.
Building an Implementation Toolset for E-Prescribing
This project developed two e-Prescribing implementation toolsets, one for independent pharmacies, and the other for health care provider organizations.
Pilot Testing of Electronic Prescribing Standards
This project, one of five grants awarded by the Agency for Healthcare Research and Quality to conduct electronic prescribing (e-prescribing) pilots, evaluated six standards that were being considered for e-prescribing under Medicare Part D.
State and Regional Demonstration in Health Information Technology: Indiana
The Indiana Network for Patient Care, an operational health information exchange (HIE) in central Indiana, is one of six AHRQ sponsored State and Regional demonstration projects begun in late 2004 and early 2005 to create State or regional HIEs.


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As a journalist for thirty years I've been lucky enough to live and work professionally in London, England, Washington, D.C., Florence, Italy, and Toronto, Canada, where I now live. During that time I've written for numerous magazines and newspapers, and have also done broadcast work. My major focus has been business, the economy, and international trade, but I've also written about politics and entertainment. As the author of more than a dozen books I won the National Business Book Award for Who Killed Confederation Life? and the Canadian Authors Association award in history for the #1 best-seller, The Eatons: The Rise and Fall of Canada's Royal Family.
Industry :
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Everyone must stay at home to help stop the spread of coronavirus.
You should only leave the house for very limited purposes:
Important - These reasons are exceptions – even when doing these activities, you should be minimising time spent outside of the home and ensuring you are 2 metres apart from anyone outside of your household.
There is separate advice about staying at home if:
Do not leave your home if you have either:
To protect others, do not go to places like a GP surgery, pharmacy or hospital. Stay at home.
Use the 111 online coronavirus service to find out what to do.
Only call 111 if you cannot get help online.
Read general information such as:
Strathesk Medical Practice, 109-111 High Street, Bonnyrigg, EH19 2ETTel: 0131 322 9333
The practice will be closed on Friday 14th April and Monday 17th April, and will reopen on Tuesday 18th April. Please note that we are only able to offer emergency appointments on 18th April.
If you require urgent medical attention while the practice is closed, please telephone NHS 24 on 111. In the case of an emergency, please dial 999 for an ambulance.
Due to an increasing number of requests for repeat prescriptions to be issued urgently, priority will only be given for prescriptions that cannot be missed eg diabetic medications, inhalers, angina sprays and epilepsy medication.
Most medications can safely be missed for a few days and you may be advised that your prescription will be issued routinely.
Please note that in order to ensure patient safety, we do not accept any requests for medication over the telephone.
Travel Clinic – Temporary Change to Services Due to Covid 19
We are currently unable to provide a travel clinic service.
Some other local clinics that we are aware of that you may wish to use include*:
Western General Hospital Travel Clinic
Crewe Road South
Telephone: 0131 537 2822
EIHC Travel
Carberry Estate
East Lothian
Telephone: 0845 375 2545
Email: travel:@eihc.org
Superdrug Travel Clinic
83 Princes Street
Telephone: 0131 220 2783
*Please note that Strathesk Medical Practice does not promote these services and is completely independent from them. These are not recommendations and other private travel clinics are available.*
Your local pharmacy will also be happy to discuss medications with you, including malaria tablets.
The NHS Fit For Travel website provides lots of useful information and up to date news and travel health advice.
There is further information about countries and vaccinations required on the links below
Australasia and Pacific
Travelling in Europe
If you are visiting Europe, you may find it helpful to visit https://ec.europa.eu/info/live-work-travel-eu_en for travel and health advice.
Other Leaflets
Copyright 2006 - 2020 My Surgery Website | Privacy & Usage | Edit | Staff Home | Site Map | Accessibility | Site T&C's | Service T&C's


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Local Guy Devotees Into Disabled Dating
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- 32
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i have short brown hair,brown eyes,2 piercings,10 tattoos, i stand around 6'0 6'1 weight bout 220-230
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I would like to get to know and possibly start a relationship with a sweet, good natured girl. More to come, but at this point it's mostly about the pics anyway, right?


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Chanel Swirled Logo Pendant Necklace
$ 1,375.00
- 1997
- Chanel
- Gold Plated
- Pendant Necklace
- Round Link Gilt Chain
- Logo Clasp Pendant
- Swirls Gilt Logo Pendant
- Chain Length 27"
This item has been checked and inspected by an in-house specialist who ensures authenticity.
All measurements are approximate.
Back To Necklaces Previous Product Next Product


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The best times to visit Texas for ideal weather are. March 12th to May 20th. or. October 1st to November 25th. based on average temperature and humidity from NOAA (the National Oceanic and atmospheric administration). read below for more weather and travel details.
The busiest month for tourism in Waco, TX, US is April, followed by March and July. Prices for hotels and flights will be most expensive during these months, though you can save if you purchase well in advance. Tourists are unlikely to visit Waco in October. Those willing to visit at these times will likely find it the least expensive month.
4. Re: Best month to visit. Apr 25, 2017, 2:18 PM. Yes, October is generally a nice month to come to Texas. If you plan to visit big bend np, be advised that the Chisos Mountain Lodge is the only place inside the park to stay, unless you camp.
A visit to New York City invariably means a lot of walking around outside, and early fall is by far the best time of year to do that. The stagnant summer-in-the-city heat has given way to pleasant.
and I was basically his travel agent and his administrator. It was fun to watch him and be his assistant. We'd go to.
Gas Prices In Midland Texas Texas Gas Prices provided by GasBuddy.com: Click here to add this map to your website. lowest gas prices in Midland: Midland Gas Prices provided by GasBuddy.com: Lowest Gas Prices in Odessa:. Search for cheap gas prices in Midland, Washington; find local midland gas prices & gas stations with the best fuel prices.
If you're looking for the very warmest time to visit Texas, the hottest months are August, July, and then June. See average monthly temperatures below. See average monthly temperatures below. The warmest time of year is generally early to mid August where highs are regularly around 96.9F (36.1C) with temperatures rarely dropping below 76.1F (24.5C) at night.
In early 2016, Joseph Potter traveled to the Rio Grande Valley to discuss worrisome findings about contraception access in Texas. As a professor of sociology at the University. ask other questions.
Find the Best Time To Go To San Antonio for the Weather with the When To Travel Guide. Choose Your Preferred Temperature, Sunshine Hours and More to San Antonio, Texas
Find the Best Time To Go To Galveston for the Weather with the When To Travel Guide. Choose Your Preferred Temperature, Sunshine Hours and More to Galveston, Texas


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New York, NY, United States
Name of organization the pet(s) is available through, or was adopted from [optional]
Posh Pets
Pet's Bio or Adoption Story
Once you look beyond that scary bear suit, you'll see there is a fuzzy little dog inside. That's Mikey, being the nosy little Yorkie/Havanese/whatever your best guess is that day (depending on how I trim his hair).
About six years ago I while I was photographing an adoption event here in New York, I decided to try fostering. That's when Bodhi, the beautiful black pit bull mix came home with me. Then there was Strawberry, Brownie, and Charlie. And then...my landlord called. There had been anonymous complaints and I couldn't have those "types of dogs" anymore. Each of these angels were quiet and friendly and I took the stairs instead of the elevator, but alas...
my building was officially "no dogs", so I had no recourse.
I called Posh Pets because I knew they had a lot of smaller dogs. I asked them to set me up with a small dog that my neighbors wouldn't worry about. (There were/are other dogs in the building so I wasn't worried I'd have to send the little one back).
The next day I got Mikey! Mikey has been an adventure ever since. I had him for over six months and no takers, he didn't do so great on meet and greets. I will admit I was secretly happy each time because I was in love with this antisocial little partially bald eats all the cat food don't you dare touch me while i'm sleeping little human/dog.
We'd later have some struggles. Mikey has Atypical Cushings Disease, suffered through Pancreatitis, and now has Diabetes. He gets injections every day and has become pretty grouchy about it, so he gets extra spoiled. He's managed to "train" me to hand feed him while he lounges on his pillow. He has a variety of outfits so he doesn't get cold from his hair loss due to the Cushings (hence my favorite, the bear suit). My vet jokes that they are going to build a wing onto the building from all of our visits. We laugh as a single tear drop rolls down my cheek. Then I take all the free pens.
I'm so thankful Mikey and I ended up together. There's nothing I wouldn't do to keep him healthy and happy. In fact I'll have to end this here as he's waiting on his "dinner pillow", so I'd better get my apron on.
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