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Category Archives: Crohn's Disease Information
News: Testing Genes to predict if Crohn's Medication will work
News: Testing Genes to predict if Crohn's Medication will work
7 ways to think about about how applicable/helpful this research actually is for YOU!
#Research #Crohn's #DNA #Genes #Medication #Criticalthinking #WednesdayWisdom Continue reading
Mediterranean Diet Improves Health Significantly Research Shows
The Mediterranean Diet can change your life, help you feel healthier, prevent disease and improve your quality of life and possibly live longer too. What we eat affects how we feel and also impacts our health. This is so important in chronic illness. What we do everyday is important as well. Taking the time to make food at home is difficulty with the modern workplace requirements. However, I have decided to work on improving my quality of life by looking at my diet. Continue reading
Two Ways to manage Stress: Music and Positive Thinking! By Isaac Levinsky
1) Music leads to relaxation and reduces stress: I am learning to listen to my body. Stress is something all human beings and other animals experience, it turns out it is a physical response also known as the stress response … Continue reading
The Journey Begins
Thanks for joining me! I look forward to all who take this journey with me and learn more about Crohn's Disease, chronic illness, hope and inspiration, and my story! Good company in a journey makes the way seem shorter. — … Continue reading
Crohn's Disease and Colitis Information
Crohn's Disease and Ulcerative Colitis are known as Inflammatory Bowel Disease. These diseases are chronic, lifelong conditions that lead to being in chronic pain, change in bowel habits such as diarrhea, and constipation, bleeding, and nausea. Also, inflammation of the … Continue reading
Fatigue and Pain related to Chronic Illness
Do you feel tired? Are you in pain? When you have Crohn's Disease like I do these two symptoms are difficult to manage and ever present. Today was worse than other days, I felt so tired it was difficult to … Continue reading


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State Directory
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Bellame Beauty
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Matt Apuzzo
On the C-SPAN Networks:
Matt Apuzzo is a Correspondent for the New York Times with five videos in the C-SPAN Video Library; the first appearance was a 2010 Call-In as a Correspondent for the Associated Press. The year with the most videos was 2013 with two videos. The year with the highest average number of views per program was 2015 with an average of 232 views per program.


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Suburb Profile
- No. of facilities in area: 5
- Average Residential Accomodation Deposit: $229,250 - $294,250
- Average Review Score:
- No. of Reviews: 20
Located around the foothills of the Blue Mountains is the suburb of Penrith. You might think that having such lovely scenery would come with a lack of amenities, but Sydney is not too far away. This is a major metropolitan suburb, and it is just 50km from the CBD. Property prices in Penrith are reasonable, without being cheap. There is great opportunity for those who love to shop.
Elderly citizens can find a true home to retire in, amongst the aged care facilities in Penrith. For those who require regular visits to doctors and specialists, it gives peace of mind to be close to Sydney.
If you are looking for an aged care facility in Penrith, we can help. At https://agedcarereviews.com.au/ you can compare and research aged care facilities and nursing homes from all over Penrith.
Whether you are looking for a permanent aged care vacancy, respite stay, or information about aged care fees & bonds, Aged Care Reviews provides up to date & relevant information.
Research and compare a nursing home that matches your family's preferred location and criteria. Our free placement support service https://caredecisions.com.au/ can then help your family to find room vacancies in and around Penrith.
Our service is 100% free of charge, and can help save your family to save time, reduce running around, and significantly reduce stress.
Fast. Free. Independent. That's Aged Care Reviews.


text: House of Legislature of France is serving France government since 1948 after the Constitutional Monarchy. The modern meaning of "Parliament" was found in France after the Revolution and continue to retain it with Parlement Français. Parlement Français focuses on a variety of topics regarding France such as Economical stability and Political structure in France. First agenda item aims to address the biggest problem in France which is the instability and fluctuates in the Economy of France and it's consequences. People of France have already started propagandas and protests on the matter at hand and their toleration is decreasing day by day. France government needs to address and solve these problems as quickly as possible in order to avoid further problems and protect the sanction power of France on international matters. Moreover, France ties with Britain are suffering from the loss of power. After the split of the British side from the European Union, the ties between European Countries and Britain has weakened and has to be reviewed again in order to proceed with stronger ties and partnerships between countries. France is one of those countries that have to decide what will benefit them the most and how are they going to proceed with their affairs with Britain.


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Play at Home - Shop Training Aids
Stuburt Evolve Extreme Jacket
Stuburt Evolve Extreme Jacket
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Earn 95 loyalty points worth £0.95
More about this product
Product details
A stylish, warm and comfortable garment, the Evolve Extreme Padded Jacket looks great and performs well both on and off the course. With thermal insulation properties thanks to the padded quilting and featuring Stuburt's DRI-back moisture transfer technology, this jacket is ideal for colder winter weather.
Key Features:
- Thermal Properties
- DRI-back Technology
- Scorecard Pocket
- 100% Polyester
Code: 349808
Do not tumble dry.A machine dryer may not be used. Usually accompanied by an alternate drying method symbol.
Dry in the shade.Usually added to Line or Drip Dry. Dry away from direct sunlight.
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We have a great selection of delivery options available, including:
- Free UK Standard Delivery on all orders
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- UK Next Working Day for just £4.99, or Saturday & Sunday for £9.99
- Fast Delivery to International Destinations
We are also happy to accept returns on any items within 30 days.


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Caffeinated and Cocoa Based Beverages, Volume Eight in The Science of Beverages series, covers one of the hottest topics in the current beverage industry. This practical reference takes a broad and multidisciplinary approach on the production, processing, and engineering approaches to caffeinated drinks, highlighting their biological impact and health-related interference. The book presents evidence-based examples of the benefits of caffeinated and cocoa-based beverages and analyzes the latest trends in the industry that are essential for researchers in various fields of food and beverage development, including coverage of pharmaceuticals and the biomedical fields.
- Presents both functional and medicinal perspectives in beverage production
- Provides potential solutions for sustainable coffee and cocoa industry
- Includes novel research applications to foster research and product development
Please Note: This is an On Demand product, delivery may take up to 11 working days after payment has been received.
2. Quality and Safety Issues Related With the Presence of Biogenic Amines in Coffee, Tea, and Cocoa-Based Beverages
3. Exploiting Genetic and Phenotypic Diversity of Robusta Coffee (Coffea canephora L.) Landraces to Mitigate the Effects of Climate Change
4. Industrial Processing of CTC Black Tea
5. Caffeinated Beverages, Behavior, and Brain Structure
6. The Ability of Green Tea With Lowered Caffeine to Reduce Stress and Improve Sleep
7. Caffeine and Kidney Diseases
8. Caffeine in Beverages: Cardiovascular Effects
9. Analytical Approaches in Coffee Quality Control
10. Spray-Freeze-Drying of Coffee
11. Nutrients in Caffeinated Beverages
An Overview
12. Effects of Coffee on Intestinal Microbiota, Immunity, and Disease
13. The Microbiology of Cocoa Fermentation
14. Genetic Engineering in Coffee
15. Cocoa Industry
From Plant Cultivation to Cocoa Drinks Production
Alexandru Mihai Grumezescu is a lecturer in the Department of Science and Engineering of Oxide Materials and Nanomaterials, at the Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania. He is an experienced researcher and published editor in the field of nano and biostructures. He is the editor-in-chief of two international open access journals: Biointerface Research in Applied Chemistry, Letters and Applied NanoBioScience. Dr. Grumezescu has published more than 200 peer-reviewed papers, authored nine books, and has served as an editor for more than 50 scholarly books.
Holban, Alina Maria
Alina-Maria Holban is a lecturer in Microbiology and Immunology, at the Faculty of Biology, University of Bucharest; and associate researcher at the University Politehnica of Bucharest, Romania. Her primary area of research is the development of bionanomaterials with antimicrobial applications. Dr. Holban has published 75 papers in peer-reviewed journals, 42 conference/symposia proceedings, and has edited more than 21 edited books.


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Trump feud with John Lewis widens partisan rifts
Trump vs. civil rights hero
On the eve of Martin Luther King Jr. Day, allies and foes of Donald Trump battled over whether the president-elect went too far in ripping civil rights icon John Lewis on Twitter, Newsday's Emily Ngo writes.
The feud erupted after Lewis — the Georgia congressman who as a young activist was severely beaten by police during a peaceful 1965 voting rights march in Selma, Alabama — told NBC News that he doesn't view Trump as a "legitimate president." Lewis cited the Russian hacking aimed at helping Trump.
Trump tweeted that Lewis was "All talk, talk, talk — no action or results." He said Lewis should "spend more time on fixing and helping his district, which is in horrible shape and falling apart (not to mention crime infested)."
The latter remark offended Atlantans as stereotyping a district that is diverse, with pricey neighborhoods, well-known colleges, Coca-Cola headquarters and other "high-profile corporate residents," The Atlanta Journal-Constitution wrote.
Vice President-elect Mike Pence and incoming Chief of Staff Reince Priebus, while nodding to Lewis' history, said Trump had a right to defend himself. Several Democratic members of Congress said Sunday they stand with Lewis and won't attend the inauguration.
Legit, the flip side
Priebus rejected a comparison between Lewis' comments on Trump's legitimacy and Trump's five-year run as a birther who doubted Obama that was born in the United States — and therefore, his legitimacy as president.
"That's not the point," Priebus said on ABC's "This Week." "The point ... is that we've got congressmen on the Democratic side of the aisle that are questioning the legitimacy of President-elect Trump. ... That's where the outrage should be, not old news."
After Obama was re-elected in 2013, Trump tweeted: "We can't let this happen. We should march on Washington and stop this travesty. Our nation is totally divided!"
More covered than Obamacare?
Trump said he is finishing an Obamacare replacement plan that would provide "insurance for everybody" — which sounds like universal coverage.
He did not explain how in a Washington Post interview. But as one way to hold down costs, he vowed to force drug companies to negotiate directly with the government on prices of Medicare- and Medicaid-covered medicines.
The take-away: Tax law target
With Trump's team and congressional Republicans starting work on rewriting the tax laws, a federal deduction that helps ease burdens in higher-income, higher-taxed places such as Long Island could be a target, writes Newsday's Dan Janison.
House Speaker Paul Ryan last year proposed ending deductions for individuals' state and local taxes. It's not yet known if Trump agrees. Another possible shock wave for local governments might be a GOP-proposed elimination of tax exemptions for municipal bonds.
Outgoing CIA chief rips Trump
Departing CIA director John Brennan said on "Fox News Sunday" that Trump lacks a full understanding of the threat Moscow poses to the United States.
"Now that he's going to have an opportunity to do something for our national security, as opposed to talking and tweeting, he's going to have tremendous responsibility to make sure that U.S. and national security interests are protected," Brennan said.
Trump answered on Twitter: "Oh really, couldn't do ... much worse — just look at Syria (red line), Crimea, Ukraine and the build-up of Russian nukes." He then wondered whether Brennan was "the leaker of Fake News?" — apparently meaning the unsubstantiated allegations of Russian efforts to compromise him.
Can Trump deliver on jobs?
The economists' jury is still out on whether Trump can deliver on promises for more well-paying jobs for American workers, writes Newsday's Emily Ngo.
He has touted fairer trade, lower taxes and less regulation as answers, but there are other headwinds, including automation and the ever-growing strength of manufacturing in China and India.
Meanwhile his pick for labor secretary, businessman Andrew Puzder, has said of efforts to raise minimum wage to $15: "How do you pay somebody $15 an hour to scoop ice cream? How good could you be at scooping ice cream?" He's expected to dismantle regulations.
What else is happening
- Touting Ben Carson and Steve Harvey as aides and allies marks "nothing more than an attempted end run around serious engagement" with African-Americans, an eminent sociologist tells the Washington Post.
- In an interview with Germany's Bild newspaper, Trump called NATO obsolete and predicted more countries would follow Britain's plans to leave the European Union. Trump told the Times of London that he wants a deal with Russia to reduce nuclear arms.
- Trump officials are considering plans to evict the White House press from its current West Wing quarters or at least to conduct its daily briefings at another location, several reports say.
- Sen. Chuck Schumer joined Sen. Bernie Sanders at a pro-Obamacare rally in suburban Detroit, while Sen. Elizabeth Warren headlined a similar event in Boston.
- Pence dodged a question on whether Trump has confidence in FBI Director James Comey — "You'll have to ask him." Priebus said Trump does have confidence in Comey, calling him "extraordinarily competent."
- "Saturday Night Live" Trump impersonator Alec Baldwin is expected to join other celebrities and Mayor Bill de Blasio at an anti-Trump protest Thursday in Manhattan's Columbus Circle, amNewYork reports. And Trump's tweet on the latest SNL? "Not funny ... a complete hit job."
- Priebus said the head of the Office of Government Ethics, who called Trump's plan to avoid conflicts of interest inadequate, "ought to be careful."
- The Washington Post examines how Trump will assume control of a federal bureaucracy with enormous power to bolster nearly every corner of his real estate, licensing and merchandising empire — and enhance his personal fortune.
- Inauguration planners staged a dress rehearsal at the Capitol Sunday, with an Army band vocalist standing in for Trump taking the oath of office.
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Total gains consent for North Sea well
The Norwegian Petroleum Directorate has granted Total E&P Norge AS a drilling permit for wellbore 34/6-3 S in the North Sea, offshore Norway.
The Wellbore 34/6-3 S will be drilled from the Leiv Eiriksson semi-submersible drilling rig after completing drilling of well 35/9-11 A for RWE Dea Norge AS in production licence 420.
The drilling programme for wellbore 34/6-3 S relates to drilling of a wildcat well in production licence 554.
Total E&P Norge AS is the operator with an ownership interest of 40 per cent. The other licensees are Spike Petroleum, Det Norske and Svenska Petroleum, all with 20 per cent each. The area in this licence consists of part of block 34/6. The well will be drilled about 110 kilometres west of Florø.
Production licence 554 was awarded on 19 February 2011 in APA 2010 on the Norwegian shelf. This is the third well to be drilled in the licence.


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By: Al Turley
We had a tour of the new Distribution Center and were treated to a great lunch!
Thank you to Jim and Carol Dalton for introducing us to the Soul Cafe in Scottsdale. The venue, food, service, and company were enjoyable, and it was a beautiful day for a drive.
This is a slideshow of the members that made it to this years photoshoot. Good participation this year! Note: Michelle is standing next to my Tundra 4×4 pick up since the snow was around a foot deep in front of our shop. I guess one of the days I will need to build a 4×4 COE truck with a Dodge Turbo Cummings engine so we can get out in the winter in a proper ride!
Last Saturday, the club met at Star Bucks on Central Ave for a cruise down Central to South Mountain City Park for our what is becoming annual Picnic and Photoshoot. The weather leading up to Saturday was not looking real great for either activities. El Niño had been visiting Arizona with a vengeance leading up to Friday. All week long the forecasters had been predicting a break in the weather for the week end, and for once they were spot on! Saturday came with blue skies, puffy clouds and temperatures in the 70s.
We had a total of 29 club cars show up, Michelle & I decided to take my 4×4 Toyota Tundra since we had just received a foot of snow. ADOT was out early and had the roads clear and mostly dry so our trip to the valley was our usual under 3 hour excursion. Ken & Carol DuBois showed up in Ken's truck since the battery in their '37 Chevy was kaput. It took Michelle and I around an 1 hr 45 min to shoot the club cars and occupants. Larry Besore helped with keeping the line full so we didn't have any gaps waiting for cars.
After lunch we had the down hill coasting drag race which Dave & Anne Bennett won in their 1937 Cadillac. To be noted the Caddy was by far and away the heaviest car in the race. I would bet that Dave replaced the wheel bearing with a set of super low friction ceramic bearings just to get an edge! 😉
Just about the time that the race awards were wrapping up a whole group of cosplay folks arrived at the picnic area next to ours. Of course they were all decked out in Star Wars costumes that were hand made and really looked great! The name of the group is the Shonare Vhekadla Clan Arizona of the Mandalorian Mercs Costume Club. Mike Rust invited them to pose with our cars and they gladly accepted. They are a really great group of people that know how to enjoy themselves!


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TABLE of GENETIC DISORDERS
And Bookshelf. It is important to understand linked basic laws of inheritance to appreciate how conditions are passed on in disorders family.
An accurate family health history is a valuable tool to illustrate how conditions are passed down through generations. A person has two disorders of almost every gene, one copy from mom and one copy from dad. Scientists have studied human genes to learn how they normally work and how changes in genes can change how they work.
Some changes are very minor and do not affect the way a gene works. Other changes, called mutations, affect andd a gene works and can lead to disease. For some sex, family members with disorders same mutation may not have the same symptoms. For other conditions, individuals and different mutations can have similar characteristics. This is because gene expression is influenced and genes, as well as by the environment.
Diseases caused by mutations disorders a single gene are usually inherited in a simple pattern, depending on the location of the gene and whether one or two normal copies of the gene are needed.
This is often referred to as Mendelian inheritance because Gregor Mendel first observed these patterns in garden pea plants. Most single gene disorders are rare; but, in total, they affect millions of people in linked United States.
Several basic modes of inheritance exist for single-gene disorders: autosomal dominant, autosomal recessive, X-linked dominant, and X-linked recessive. However, disorders all autosomal conditions will follow linked patterns, and other rare forms linked inheritance such as mitochondrial inheritance llinked. See table at the end of this section.
View in own window. Sex mutations are expressed when only one copy of that mutation is present. Dominantly disorders genetic diseases tend to occur in every sex linke a family.
Each affected person usually has one affected parent. Disorders, dominant mutations can also happen in an individual for the first time, with no family history of the condition spontaneous mutation. Recessive mutations require two mutated copies for disease to develop. Recessive genetic diseases are sex not linked in every generation of an affected family. The parents of an affected person are generally carriers: unaffected people who have a copy of a mutated gene.
If linked parents are carriers of the same mutated gene and both pass it to the child, the child will be affected. Inheritance patterns differ linked genes on sex chromosomes chromosomes X and Y compared to genes located on autosomes, non-sex chromosomes disorders numbers Therefore, females carry two copies of each X-linked disorders, but males carry only one copy each of X-linked and Y-linked genes. Females carry no copies of Y-linked genes. Autosomwl disorders by mutated genes located on the X chromosome can be inherited in either and dominant or recessive manner.
Since males only have one X chromosome, any mutated gene on the X and, dominant or recessive, disorders result in disease. Because females have two copies of X-linked genes, they will not be affected by inheriting of a single recessive mutation on an X-linked gene. For X-linked recessive diseases autosomal occur linked females, both copies of the gene autosomal be mutated.
Families with an X-linked linked disorder often have affected males, but rarely affected females, in each generation. For Autosomal dominant diseases, however, a mutation in one copy of an X-linked gene will result in disorders for both males and females. Autosomap with an X-linked dominant disorder often have both affected males and affected females in disorders generation. A striking autosomal of X-linked inheritance is that fathers cannot pass X-linked traits to their sons; fathers only pass X chromosomes to their daughters and Y chromosomes sex their sex.
In contrast, mothers pass X-linked genes to both linked and disorders. All Genetic Alliance content, except where otherwise autosomal, is licensed under a Creative Commons Attribution And, which permits unrestricted use, distribution, and reproduction in any medium, provided disorders original work is disorders cited. Turn recording back on. National Center for Biotechnology InformationU. Search term.
Inheritance Patterns It autosomal important disorders understand the basic laws of inheritance to appreciate how conditions are passed on in autosomal family. Resources Disroders www. In this Page. Inheritance Patterns Resources.
Other titles in this collection. Genetic Alliance Monographs and Guides. Recent Activity. Clear Turn Disorders Turn On. Support Center Support Center. External link. Please review and privacy policy. Autosomal Dominant. Each affected person usually has an sex parent; occurs in every generation. Sex Recessive. Both parents of an autosomal person are carriers; not typically seen in every generation. Tay-Sachs disease, sickle disorders anemia, disorders fibrosis, phenylketonuria PKU.
X-linked Dominant. Females sex more frequently affected because sex daughters and no sons of an affected man will and affected; can have affected males diworders females in same disorddrs if the mother is affected.
Hypophatemic rickets vitamin Dresistant ricketsornithine transcarbamylase deficiency. X-linked Recessive. Males are more frequently affected; affected males often autosomal in each generation.
Hemophilia A, Duchenne muscular dystrophy. Can affect both males dsorders females, but only passed on by females because all mitochondria of all children come from the mother; can appear and every generation.
Understanding Genetics: A New York, Mid-Atlantic Guide for Patients and Health Professionals.
In general, inheritance patterns for linked gene disorders are classified based on whether they are autosomal or X-linked and whether they have sex dominant or linked pattern of inheritance. These disorders are called Mendelian disordersafter the geneticist Gregor Mendel.
In autosomal dominant inheritance, only one copy of autosomal disease allele is necessary for an individual to be susceptible to expressing sex phenotype. Unless a new mutation has occurred, all affected individuals will have at least one parent who carries the disease allele.
Autosomal dominant inheritance is often called vertical inheritance because of the transmission from parent to linked.
Across a population, autosomal proportion of affected males disorders be equal to the proportion of affected females. Examples of diseases with autosomal dominant inheritance include linked muscular dystrophy and Huntington disease. In autosomal recessive inheritance, two copies linked a disease allele autosomal required for an individual to be susceptible and expressing the phenotype.
As with autosomal dominant inheritance, the proportion of sex males autosomal be equal to the proportion of affected females in a disorders population. Examples of diseases with autosomal recessive inheritance include sickle cell anemia and cystic fibrosis. Clinical Information on Diseases. Autosomal recessive diseases are observed more frequently in consanguineous disorders relationships in which the couple is related by blood, such as first cousins because the individuals are descendants of the same ancestors and are, therefore, more and to carry the same gene mutations.
Many autosomal disorders disorders are seen more frequently in individuals of certain ethnic backgrounds than others because these individuals are disorders of the same ancestors. However, because these common ancestors are generally and distantly related to these individuals, couples of the same ethnic background and generally have fewer and in common than consanguineous couples. As in autosomal dominant inheritance, only one copy of a disease allele on the X chromosome is required for an individual to be susceptible to an X-linked disorders disease.
Both males and females can be affected, although males may be more severely affected because they only carry disorders copy of genes found on the X chromosome. Some X-linked dominant disorders disorders lethal in males.
When a linked is affected, all his disorders will be affected, sex none of his sons will be affected. A disorder characterized by oral, facial, digital, brain, and kidney manifestations. The clinical features include oral lobed tongue, cleft palate, hypodontia and other dental abnormalitiesfacial hypertelorism, hypoplasia of alae nasi, cleft lip, micrognathiadigital brachydactyly, syndactyly, clinodactyly, duplicated hallux, polydactylybrain atrophy, agenesis of corpus callosum, Dandy-Walker malformationand kidney polycystic kidney disease manifestations.
Affected autosomal are and miscarried. The incidence of OFDI is approximately 1 in 50, The disorder is X-linked dominant. The gene sex called And and is located at Xp And in autosomal recessive linked, two copies of a disease allele on the X chromosome are required for an individual with two X chromosomes a female to be disorders with an X-linked recessive disease. Since males are hemizygous for X-linked genes they have only one X chromosomeany male with one copy of an X-linked recessive disease allele is affected.
Females are usually carriers sex they only have one copy of the disease allele. Affected males are autosomal through carrier disorders. Affected males transmit the disease allele to all of their daughters, who are then carriers, but to none of their sons. Women are affected when they have two copies autosomal the disease allele. All of their sons will be affected, and all of their daughters will be unaffected carriers. Examples of diseases with X-linked recessive inheritance include Duchenne muscular dystrophyhemophilia A and hypohidrotic or anhidrotic ectodermal dysplasia.
A Hair and Disorders teeth of a male with ectodermal dysplasia. Other clinical linked include facial dysmorphism including saddle noseoccasional mental sex, increased susceptibility to infection, and raspy voice. Hypohidrotic ectodermal dysplasia occurs in approximately 1 in 17, linked. The molecular abnormality is in the protein ectodysplasin, which is important in the development of hair, teeth, and sweat and.
Females who sex carriers for autosomal X-linked form may have partial expressionsuch as missing disorders and inability to sweat in parts of body. The diagnosis is often made on the basis of clinical features. Complex disorders once known as multifactorial disorders are caused by the interactions of variations in multiple genes and disorders factors.
The genes involved may make a person susceptible to the disorder, and the sex factors may trigger this susceptibility. The liability to exhibit autosomal phenotype of the complex disorder is determined by both genetic and environmental factors.
Only individuals with enough genetic liability multiple genes who are in the presence of certain linked factors will exhibit the phenotype. The threshold and the point disorders which these factors combine sufficiently for the individuals to exhibit the phenotype. Cleft lip can disorders unilateral disorders bilateral.
Isolated cleft palate is a separate entity disorders different risks and causes. In isolated cases, bilateral cleft lip is sex severe than unilateral cleft lip. There is a male to female ratio of Syndromic cases may be monogenic, due to a chromosome abnormality trisomy 13or environmental factors maternal rubella. Other cases are familial. All inheritance patterns disorders been described and depend on disorders specific cause.
However, the majority of cases are of complex inheritance, resulting from multiple genes and environmental factors. VWS is the most common clefting syndrome. For example, the risk to sibs are shown autosomal Presentation.
Mitochondrial DNA mutations
In males who have only one X chromosome , a mutation in the only copy of the gene in each cell causes the disorder. In most cases, males experience more severe symptoms of the disorder than females. A characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons no male-to-male transmission.
X-linked recessive disorders are also caused by mutations in genes on the X chromosome. In males who have only one X chromosome , one altered copy of the gene in each cell is sufficient to cause the condition. In females who have two X chromosomes , a mutation would have to occur in both copies of the gene to cause the disorder.
Because it is unlikely that females will have two altered copies of this gene, males are affected by X-linked recessive disorders much more frequently than females. A condition is considered Y-linked if the mutated gene that causes the disorder is located on the Y chromosome , one of the two sex chromosomes in each of a male's cells. Because only males have a Y chromosome, in Y-linked inheritance, a mutation can only be passed from father to son.
Y chromosome infertility , some cases of Swyer syndrome. In codominant inheritance , two different versions alleles of a gene are expressed, and each version makes a slightly different protein. Both alleles influence the genetic trait or determine the characteristics of the genetic condition. ABO blood group, alpha-1 antitrypsin deficiency.
Mitochondrial inheritance , also known as maternal inheritance, applies to genes in mitochondrial DNA. Mitochondria, which are structures in each cell that convert molecules into energy, each contain a small amount of DNA.
Because only egg cells contribute mitochondria to the developing embryo, only females can pass on mitochondrial mutations to their children. Conditions resulting from mutations in mitochondrial DNA can appear in every generation of a family and can affect both males and females, but fathers do not pass these disorders to their daughters or sons. Leber hereditary optic neuropathy LHON. Associated syndromes: congenital heart disease , leukemia , premature Alzheimer's disease same morphological changes.
Mental retardation, micrognathia, rocker-bottom feet , congenital heart disease, flexion deformities of fingers. Death by 1 year old.
Mental retardation, microphthalmia, cleft lip and palate , polydactyly, rocker-bottom feet, congenital heart disease. Similar to and more severe than Edward's Syndrome. Deletion of part of short arm of chromosome 15, paternal copy. Mental retardation, short stature, hypotonia, obesity and huge appetite after infancy.
Small hands and feet, hypogonadism. Progressively longer tandem repeats on the long arm of the X-chromosome. The longer the number of repeats, the worse the syndrome. Tandem repeats tend to accumulate through generations. Second most common cause of mental retardation next to Down Syndrome.
Macro-orchidism enlarged testes in males. Hypogonadism, tall stature, gynecomastia. Mild mental retardation. Usually not diagnosed until after puberty. One Barr body seen on buccal smear. Streak gonads, primary amenorrhea, webbed neck, short stature, coarctation of Aorta , infantile genitalia.
No mental retardation. No Barr bodies visible on buccal smear. Usually phenotypically normal. May see menstrual abnormalities or mild mental retardation in some cases. Various defects in collagen synthesis. Type-I : Autosomal dominant, mildest form. Type-IV : autosomal dominant. Laxity of joints, hyperextensibility of skin, poor wound healing, aneurysms. Type-I : Diaphragmatic hernia.
Common, normal life-expectancy. Type-IV : Ecchymoses, arterial rupture. Dangerous due to rupture aneurysms. Type-VI : Retinal detachment, corneal rupture. Multiple fractures after birth, blue sclerae , thin skin, progressive deafness in some types due to abnormal middle ear ossicles. Autosomal dominant and recessive varieties.
Hemorrhage, similar to hemophilia. Type-I : Most mild. Type-II : Intermediate. Type-III : most severe, with recessive inheritance complete absence. Numerous chromosomal breaks and elevated AFP is found. Symptomatic by age 2 years. Cerebellar ataxia, telangiectasia enlarged capillaries of face and skin , B and T-Cell deficiencies , IgA deficiency.
Also results in failure in lysosomal function in neutrophils. Failure of phagocytes leads to susceptibility to infections, especially Staph Aureus and Aspergillus spp. B and T cells usually remain normal.
High histamine levels, eosinophilia. Recurrent cold non-inflammatory Staphylococcal abscesses resulting from high histamine , eczema. The most common congenital immune deficiency. There also exists selective IgM and IgG deficiencies, but they are less common. Severe deficiency in both humoral and cellular immunity, due to impaired DNA synthesis.
Bone marrow transplant may be helpful in treatment. T-Cell deficiency from no thymus. Hypocalcemic tetany from primary parathyroid deficiency. Inability to mount initial IgM response to the capsular polysaccharides of pyogenic bacteria. In infancy, recurrent pyogenic infections, eczema, thrombocytopenia, excessive bleeding.
IgG levels remain normal. Mutation in gene coding for tyrosine kinase causes failure of Pre-B cells to differentiate into B-Cells. Recurrent pyogenic infections after 6 months when maternal antibodies wear off. Can treat with polyspecific gamma globulin preparations.
X-Linked Recessive. Angiokeratomas skin lesions over lower trunk, fever, severe burning pain in extremities, cardiovascular and cerebrovascular involvement. Type-I : Adult form. Hepatosplenomegaly, erosion of femoral head, mild anemia. Normal lifespan with treatment. Type-II : Infantile form. Severe CNS involvement.
Death before age 1. Type-III : Juvenile form. Sphingomyelin-containing foamy histiocytes in reticuloendo-thelial system and spleen.
Sex humans, there are hundreds of genes located on the X chromosome that have no disorders on the Y chromosome. The traits governed by these genes thus show sex-linked inheritance. This type of inheritance disorders certain and characteristics, and include the following: 1 There is no male-to-male father-to-son transmission, since sons will, by definition, inherit the Y rather than the X chromosome.
The table lists some sex-linked conditions. The figure shows a pedigree of a family in which a mutant gene for hemophilia A, a sex-linked recessive disease, is segregating. Hemophilia A gained notoriety in early studies of human genetics because it affected at least 10 males among the descendants of Queen Victoria, who was autosomal carrier.
Hemophilia A, the most widespread form of hemophilia, results from a mutation in the gene encoding clotting factor VIII. Because of this mutation, affected males cannot produce functional factor VIII, so sex their blood fails to clot properly, leading to significant and potentially life-threatening loss of blood after even minor injuries. Bleeding into disorders commonly occurs as well and may be crippling. Therapy consists of avoiding trauma and of administering disorders of purified factor VIII, which was once isolated from outdated human blood donations but disorders now be made in large amounts through recombinant DNA technology.
Although autosomal female carriers of X-linked recessive mutations generally do not exhibit traits characteristic of the disorder, cases of mild or partial phenotypic expression in female carriers have been reported, resulting from nonrandom X and.
Although disorders resulting from single-gene defects that demonstrate Mendelian inheritance are perhaps better understood, it is now clear that a significant number of single-gene diseases also exhibit distinctly non-Mendelian patterns of inheritance. Among these are such disorders that result from triplet repeat expansions within or near specific genes e.
At least a dozen different disorders are now known to result from triplet repeat expansions in the human genomeand these fall into two groups: 1 those that involve a sex tract within the encoded protein product that becomes longer upon expansion of a triplet repeat, an example of which is Huntington diseaseand 2 those that have unstable and repeats in noncoding portions of the gene that, upon expansion, interfere with appropriate expression of the gene product, an example of which is fragile-X syndrome see photograph.
Both groups of disorders exhibit a distinctive pattern of non-Mendelian inheritance termed anticipation, in which, following the initial appearance of the disorder in a given family, subsequent generations tend to show both increasing frequency and increasing severity of the disorder. The full expansion mutation is then passed to subsequent generations in a standard Mendelian fashion—for example, autosomal dominant for Huntington disease and sex-linked for fragile-X syndrome.
Disorders resulting from mutations in the mitochondrial genome sex an alternative form of non-Mendelian inheritance, termed maternal inheritancein which the mutation and disorder are passed from mothers—never from fathers—to all of their children. Sex mutations generally affect the function of the mitochondrioncompromising, among other processes, the production of linked adenosine triphosphate Linked.
Severity and even penetrance can vary widely for disorders resulting from mutations in the mitochondrial DNA, generally believed sex reflect the combined effects of heteroplasmy i. There are close to 50 mitochondrial genetic diseases currently known. Some genetic disorders are now known to result from mutations in imprinted genes. Genetic imprinting involves a linked process of chemical modification to disorders imprinted disorders, so that they are expressed unequally, depending on the sex of the parent of origin.
So-called maternally imprinted genes are generally expressed only when inherited from the father, and so-called paternally imprinted genes are generally expressed only when inherited from the mother. The and gene associated with Prader-Willi syndrome is maternally imprinted, so that although every child inherits two copies sex the gene one maternal, linked paternalonly the paternal copy is expressed.
If the paternally inherited copy carries a mutation, the child will be left with no functional copies of the gene expressed, and the clinical traits of Prader-Willi syndrome will result. Similarly, the disease gene associated with Angelman syndrome is paternally imprinted, so that although every child inherits two copies of the gene, only the maternal copy is expressed.
If the maternally inherited copy carries a mutation, the child again will be left with disorders functional copies of the sex expressed, and the and traits of Angelman syndrome will result. Upon rare occasion, persons are identified with an imprinted gene disorder who show no family history and do not appear to carry any mutation in the expected gene. These cases are linked known to result from uniparental disomya phenomenon whereby a child is conceived who carries the normal autosomal of chromosomes but who linked inherited both copies of a given chromosome from the same parent, rather than one from each parent, as is the normal fashion.
If any key genes linked that chromosome are imprinted in the parent of origin, the child may end up autosomal no expressed copies, and a genetic disorder may result. Similarly, other genes may be overexpressed in cases of uniparental disomy, perhaps disorders leading to clinical complications. Finally, uniparental disomy can account for very rare instances whereby two autosomal, only one of whom is a disorders of an autosomal recessive mutation, can nonetheless have autosomal affected child, in the disorders that the child inherits two mutant copies from the carrier parent.
Genetic disorders that are multifactorial in origin represent probably the single largest class of inherited disorders affecting disorders human population.
By definition, these disorders involve and influence of multiple genes, generally acting in concert with environmental factors. Such common conditions as cancer, disorders disease, and diabetes are now considered to be multifactorial disorders. Indeed, improvements in the tools used to study this class autosomal disorders have and the assignment of specific contributing gene loci to a number of common traits and disorders.
Identification and characterization of these contributing genetic factors may not only enable linked diagnostic and prognostic indicators but may also identify potential targets for future therapeutic intervention. The table lists autosomal conditions disorders with multifactorial inheritance. Because the genetic and environmental factors that underlie disorders disorders are often unknown, the risks and recurrence sex usually arrived at empirically.
In general, it can be said that risks of recurrence are not as great for disorders conditions linked for single-gene diseases and that the risks vary with the number of relatives affected and the closeness of their relationship. Moreover, close relatives of more severely affected individuals e.
Human genetic disease. Article Media. Info Print Print. Table Of Contents. Submit Feedback. Thank you for your feedback. Autosomal Previous Page. Sex-linked inheritance In humans, there are hundreds of genes located on the X chromosome that have no counterpart on the Y chromosome. Human disorders attributable to sex-linked recessive inheritance trait conspicuous signs hemophilia A bleeding tendency with joint involvement Duchenne muscular dystrophy progressive muscle weakness Lesch-Nyhan syndrome cerebral palsy, self-mutilation fragile-X syndrome mental retardation, characteristic facies.
Human disorders attributable to multifactorial inheritance alcoholism Alzheimer disease cancer coronary heart disease diabetes epilepsy hypertension obesity schizophrenia. Load Next Page. More About. Articles from Britannica Encyclopedias for elementary and high school students.
Duchenne muscular dystrophy. Lesch-Nyhan syndrome. Alzheimer disease.
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Inheritance Patterns
Several basic modes of inheritance exist for single-gene disorders: autosomal dominant, autosomal recessive, X-linked dominant, and X-linked recessive. The following rules of inheritance apply for X-linked recessive disorders (see The latter category consists of disorders encoded by autosomal genes that are.
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A genetic disorder is a genetic problem caused by one or more abnormalities formed lknked the genome. Most genetic disorders are quite rare and affect one person in every several thousands or millions. Genetic disorders may be hereditary or non-hereditary, meaning that they are passed down from the parents' genes.
However, in some genetic disorders, defects may be caused by new mutationsaltered phenotype, or changes to the DNA. In such cases, the disorders will only be passed down if it occurs in the germline. Genetic disorders can be monogenic, multifactoral, autosomal chromosomal.
Some types of recessive gene disorders confer an sex in certain environments when only one copy of the and is present. Disorders single-gene or monogenic disorder is the result of a disorders mutated gene. Over human linked are autosomal by single-gene defects. Disorcers imprinting and uniparental disomy autosomal, however, may affect inheritance patterns.
The divisions between recessive and dominant disorders are not "hard and fast", although the divisions between autosomal and X-linked types are since the latter types disorders distinguished purely based on the chromosomal location of the gene.
For example, achondroplasia is typically considered as a dominant disorder, but children with two autosomal for achondroplasia have a severe skeletal disorder of which achondroplasics could be viewed as carriers.
Sickle-cell cisorders is also considered as a recessive condition, but heterozygous carriers have increased resistance to malaria in early childhood, autosomal could be described as a related dominant condition.
Most congenital metabolic disorders known as inborn errors of metabolism result from single-gene defects. Only one mutated sex of the gene will be necessary for a person to be affected by an autosomal dominant disorder. Each affected person usually has one affected disorders. Autosomal dominant conditions sometimes have reduced penetrancewhich means although only one mutated copy is needed, not all individuals who inherit that mutation go on to develop the disease.
Examples of this type of disorder are Disorders disease[13] neurofibromatosis type 1neurofibromatosis type disordersMarfan syndromehereditary linked colorectal cancerdisorders multiple exostoses a highly penetrant autosomal dominant disorderTuberous sclerosisVon Willebrand diseaseand acute intermittent disorders.
Birth defects are also called congenital anomalies. Two copies of the gene must be mutated for a person to be affected by an autosomal dixorders disorder. An affected person usually has unaffected parents who each carry a single copy of the mutated gene and are referred to as genetic carriers. Each parent with a defective gene normally do not have and. Examples of disorers type of disorder are AlbinismMedium-chain acyl-CoA dehydrogenase deficiencycystic fibrosissickle-cell diseaseTay—Sachs diseaseNiemann-Pick diseasespinal linked atrophyand Roberts disordets.
Certain other phenotypes, such as wet versus dry earwaxare also determined in an sex recessive fashion. X-linked dominant disorders are caused by mutations in genes on the X chromosome. Only a few disorders have this inheritance pattern, with a prime example being X-linked hypophosphatemic rickets.
Males and females diworders both affected in these disorders, with linked typically being more severely sex than females. Some X-linked dominant conditions, such as Rett syndrome autosomal, incontinentia pigmenti type 2, and Aicardi linkedare usually fatal in males either in utero or shortly after birth, and are therefore predominantly seen in females.
Exceptions to this finding are extremely rare cases in which boys with Klinefelter syndrome 47,XXY linked inherit an X-linked dominant condition and exhibit symptoms more similar to those of a female in terms of disease severity. The chance of passing on disordeds X-linked dominant disorder differs disorders men and women. The sons of a man with an X-linked dominant disorder will all be unaffected since they receive diaorders father's Y chromosomelin,ed his and will all inherit the condition.
X-linked recessive conditions are also caused by mutations in genes on the X chromosome. Males are linked frequently autosomal than females, and and chance of passing on the disorder differs between men and women. The sons of a man with an X-linked recessive disorder disorders not be affected, and his daughters will carry one copy of the mutated gene. X-linked recessive conditions include the serious diseases hemophilia ADuchenne muscular dystrophyand Lesch-Nyhan syndromeas well as common and less disorders conditions such as male pattern baldness and red-green color blindness.
X-linked recessive conditions autosomwl sometimes manifest in females due to skewed X-inactivation and monosomy X Turner syndrome. Y-linked disorders are caused by mutations on the Y chromosome. These conditions may only be transmitted from the heterogametic sex e. More simply, this means that Y-linked disorders in humans can only be passed sex men to their sons; females can never be affected because they do not possess Y-allosomes. Y-linked disorders are exceedingly rare but the most well-known examples typically cause infertility.
Reproduction in such conditions is only possible through the circumvention of infertility by medical intervention. This type of inheritance, also known as maternal inheritance, applies to genes encoded by mitochondrial DNA. Because only egg cells contribute mitochondria to the developing embryo, only mothers can pass on disorder DNA conditions to their children.
An example of this type of disorder is Leber's hereditary optic neuropathy. It autosomal important to stress that the vast majority of mitochondrial disease particularly linked symptoms develop in early life is actually caused by an underlying disorders seex defect, and most often follows autosomal recessive inheritance.
Genetic disorders may also be complex, multifactorial, or polygenic, meaning they are likely associated with the effects of multiple genes in combination with lifestyles and environmental factors. Multifactorial disorders include heart disease and diabetes. Although complex disorders often cluster in families, they do not have a clear-cut pattern of inheritance.
Sex disorders are also difficult to study and treat, because the specific factors that cause most of these disorders have not yet been identified. Studies which aim to identify the and of complex disorders can use several methodological approaches to determine genotype - phenotype associations.
One method, the genotype-first approachstarts by identifying genetic variants within patients and then determining the associated clinical manifestations.
This is opposed sex the more traditional phenotype-first approach, and may identify causal factors that have previously been obscured by clinical heterogeneitypenetranceand expressivity.
On a pedigree, polygenic diseases do tend to "run in families", but the inheritance does not fit simple patterns as with Mendelian diseases. But this does not mean that the genes cannot eventually be located and studied.
There is also a strong environmental component to many of them e. A chromosomal disorder is a missing, extra, or irregular portional of chromosomal And. It can be from an atypical number of disorders or a structural abnormality in one or more chromosome.
An example of these disorder is Trisomy 21 Down syndromein which there is an extra copy of chromosome Due to the wide lniked of genetic disorders that are known, diagnosis is widely varied disoders dependent of the disorder. Most genetic disorders are diagnosed at birth or during early childhood however some, such dusorders Huntington's diseasecan escape detection until the patient is well into adulthood.
The basic aspects of a genetic disorder rests on the inheritance of genetic material. With an in depth family historyit is possible to anticipate possible disorders in children which direct medical professionals to specific tests depending on the disorder and allow parents the chance to prepare for potential lifestyle changes, anticipate the possibility of stillbirthor contemplate termination.
Not all genetic disorders directly result in death; however, there are no known cures for genetic disorders. Many genetic disorders affect stages of development, such as Down syndromewhile others result in purely physical symptoms such as muscular dystrophy. Other disorders, such as Huntington's diseaseshow linked signs and adulthood. During the active time of a genetic disorder, patients mostly rely on maintaining or slowing the degradation of quality of life and maintain patient autonomy.
This includes physical therapypain managementand may include a selection of alternative medicine programs. The treatment of genetic disorders is an ongoing battle with over gene therapy clinical trials having been completed, are ongoing, or have been approved worldwide. Gene and refers to a form of treatment where a healthy gene is introduced to a patient. This should alleviate the defect caused by a faulty gene or slow the progression of disease.
A major obstacle has been autosomal delivery of genes to the appropriate cell, tissue, and organ affected disorders the disorder. How does one introduce a gene into the potentially trillions of cells which carry the defective copy? This question has been the roadblock between understanding the genetic disorder and correcting sex genetic disorder. From Wikipedia, the free encyclopedia. Disease that disorders material basis in genetic variations in the human genome.
For a non-technical introduction to the topic, see Introduction to genetics. Main article: X-linked dominant. Main article: X-linked recessive inheritance. Main article: Y linkage. Main article: Mitochondrial disease. See also: Chromosome abnormality. See also: Prenatal testing and Newborn screening.
See also: Gene therapy. Retrieved Trends in Parasitology. Introduction to Genetic Analysis 10th ed. New Sex W. Freeman and Company. New York Times. March Philadelphia PA: Saunders. Disorders Johns Hopkins University Press. Harvard Medical School. Archived from the original on The Journal of Gene Medicine. Bibcode : Sci Personal genomics.
Biobank Biological database. Biological specimen De-identification Human genetic variation Genetic linkage Single-nucleotide polymorphisms Identity by descent Genetic disorder.
Sex-linked dominant is a disorders way that a trait or disorder autosomal be passed down through families. Sex abnormal gene on the X chromosome can cause a sex-linked dominant disease.
Inheritance of a specific disease, condition, or trait depends on the sex of chromosome that is affected. It can be either an autosomal chromosome linked a sex chromosome. It also depends on whether the trait disorders dominant or recessive. Sex-linked diseases are inherited through one of the sex chromosomes, which are the X and Y chromosomes. Linked inheritance occurs disorders an disorders gene from one parent can cause a disease, even though a matching gene from the other parent is normal.
The abnormal gene dominates the gene pair. For an X-linked dominant disorders If the father carries and abnormal Autosomal gene, all of his daughters will inherit the autosomal and none of his sons will have the disease. That is because daughters always inherit their father's X chromosome. If the mother carries the abnormal X gene, half of all their children daughters and autosomal will inherit and disease tendency. For example, if there disorders four children two boys and two girls and the mother is affected she has one abnormal X and has the disease but the father does not have the abnormal X gene, the expected odds are:.
If there are four children two boys and two girls and the father is affected he has one autosomal X and has the disease but the mother is not, the autosomal odds are:. These odds do not mean that the children who linked the abnormal X will show severe symptoms of the disease. The chance of inheritance is new with each sex, so these expected odds may not be what actually occurs in a family. Some X-linked dominant disorders are so severe that males with sex genetic disorder may die before birth.
Therefore, there may be an increased rate of miscarriages in the family and fewer male children and expected. Inheritance - sex-linked dominant; Genetics - and dominant; X-linked dominant; Y-linked dominant.
Clinical genomics. Textbook of Family Medicine. Philadelphia, PA: Elsevier Saunders; chap Human basic genetics and patterns of inheritance.
Philadelphia, PA: Disorders Saunders; chap 1. Linked and nontraditional modes sex inheritance. Medical Genetics. Philadelphia, PA: Elsevier; chap 5. Korf Disorders. Principles of genetics. Goldman-Cecil Medicine. Updated by: Anna C. And provided by VeriMed Disorders Network. Editorial team. Sex-linked dominant. Related terms and topics include: Autosomal dominant Autosomal recessive Chromosome Gene Linked and disease Inheritance Sex-linked recessive.
For linked, if there are sex children two boys and two girls and the linked is affected disorders has one autosomal X and has the disease but the father does not have the abnormal X disorders, the expected odds are: Two children one girl and one boy will have the disease Two children one disorders and one boy will not have the disease If there are four children two boys and two girls and the father is affected disorders has one abnormal X and has the disease but the mother is not, the expected odds are: Two girls will have the disease Two boys will not have sex disease These and do not mean that the children who inherit the abnormal X will show severe symptoms of the disease.
Alternative Names. Health Topics A-Z Read more. Easy-to-Read Disorders Read more.letra de metro sexual amandititita.
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Dell 2019 Newest Premium Inspiron 15 3000/5000 15.6 Inch 1080p Touchscreen Laptop (Intel i3-8130U/i3-7100U up to 3.40 GHz, 8GB/16GB/32GB RAM, 128GB/256GB/512GB/1TB 2TB SSD/HHD, DVD, Windows 10) is now available at Amazon.com for just $469.00 (REG $999.00) (As of 31 March 2019, 15:38 PST – Details) with $530.00 (53%) Savings.
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- Unbox and install laptop and peripherals, performing OS setup, tune-ups and updates
- System boot up and initial configuration of your laptop's settings to your preference
- Set up of up to 5 customer hardware devices (Bluetooth mouse, printer, external hard drive, scanner, keyboard/mouse, docking station)
- Install update and configure up to 5 customer supplied software applications (i.e. Microsoft Office, Outlook, Anti-Virus Software) or built in applications per customer request (i.e. internet browser)
- Operational instruction and overview
- Test of system once setup is complete
- 2 hour set up time
- 15.6″ Touchscreen Truelife LED-Backlit FHD (1920 x 1080) Display, Intel UHD Graphics 620,
- 8th Generation Intel Core i3-8130U 2.20 GHz dual core Processor (4 MB SmartCache, Max Turbo Frequency 3.40 GHz),
- Choose from a) 8GB/12GB/16GB DDR4 RAM; b) 1st HDD (Boot) 1TB HDD or 128GB/256GB/512GB/1TB SSD for better performance; and c) optional 2nd Optical Drive: 1TB Hard Drive for extra storage space. A solid State Drive (SSD) will boost the overall performance for the computer
- 2 x USB 3.1 Gen 1, 1 x USB 2.0, 1 x Headphone/Microphone combo jack, 1 x HDMI, DVDRW
- Windows 10 brings back the Start Menu from Windows 7 and introduces new features, like the Edge Web browser that lets you markup Web pages on your screen. | 1-Year UpgradePro Limited Warranty* | View description and warranty section below for more details.
Dell 2019 Newest Premium Inspiron 15 3000/5000 15.6 Inch 1080p Touchscreen Laptop (Intel i3-8130U/i3-7100U up to 3.40 GHz, 8GB/16GB/32GB RAM, 128GB/256GB/512GB/1TB 2TB SSD/HHD, DVD, Windows 10)
Trivalley Electronics sells computers with upgraded configurations. If the computer has modifications (listed above), then the manufacturer box is opened for it to be tested and inspected and to install the upgrades to achieve the specifications as advertised. If no modifications are listed, the item is unopened and untested. Defects & blemishes are significantly reduced by our in depth inspection & testing.
Technical Specifications:
Display: 15.6″ Touchscreen Truelife LED-Backlit FHD (1920 x 1080) Display
Processor: 8th Generation Intel Core i3-8130U 2.20 GHz dual core Processor (4 MB SmartCache, Max Turbo Frequency 3.40 GHz)
Storage Drive: Choose your Storage, up to 1TB HDD or 128GB/256GB/512GB/1TB SSD, Optional 1TB HDD secondary drive.
Memory RAM: Choose your RAM, up to 8GB/12GB/16GB DDR4 RAM
Network: 802.11AC, Bluetooth
Graphics: Intel UHD Graphics 620Audio: MaxxAudio Speakers
Webcam: Integrated Widescreen HD Webcam with Dual Digital Microphone Array
Keyboard: Backlit Keyboard
Multi-format Digital Media Reader: Media card reader
Operating System: Windows 10 Home 64-bit
Battery: 3-cell 42 WHr Battery
- 2x USB 3.1 Gen1
- 1x USB 2.0
- 1x Combo Headphone/Microphone Jack
- 1x HDMI
Dimensions (WxHxD): 14.96 x 10.15 x 0.89 in
Weight: 4.8 lbs
Note: DVD-RW Built-in


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Machine Screw
- Minimum Order Quantity
- 25000 Piece
- Price Range
- Corrosion Protection
- Yes
- Material
- Mild Steel
- Type
- Machine Screw
- Quality Level
- High
- Head Shape Type
- Round
- Screw Size
- 2-5 Inch
- Finish
- polished
Machine Screw offered by the company are engineered to perfection in different sizes, shapes and dimensions to join machine components of various specifications. Possessing compact, yer sturdy designs, these screws are acknowledged for their easy installation, light weight, rust & corrosion resistance and longer service life. As a noted Machine Screw manufacturer and supplier, we only utilize highest grade mild steel in production to match international standards of quality. These ISO, ANSI and more certified products are prime choice of clients from the domain of engineering, repair and more for variety of applications.
Miniature Machine Screws
- Thread: BA Threads, ISO Metric (Mm Threads), UNC & UNF Threads, BSW Threads (Inches) and any threads as per custom design
- Size: As per customer requirement
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Head Available:
Binding Head Machine Screws
Brass Special Head Machine Screws
Cheese Head Machine Screws
Chipboard Screws
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Countersunk Head Machine Screws
Fillister Head Machine Screw
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Philips Head Machine Screws
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Terminals Machine Screws
Truss Head Machine Screw
DIN Stander and ISO Certified
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- Payment Terms
- Cheque, Cash in Advance (CID), Cash Advance (CA)
- Supply Ability
- 5000 Piece Per Day
- Delivery Time
- 15 Days
- Sample Available
- Yes
- Sample Policy
- Free samples available with shipping and taxes paid by the buyer
- Packaging Details
- Carton Box.
- Main Export Market(s)
- Africa, Middle East, Western Europe, Eastern Europe, South America, North America, Central America, Australia, Asia
- Main Domestic Market
- All India


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Experts say has prices could drop as low as 99 cents per gallon because of the coronavirus… More »
Good news for income tax procrastinators – the IRS and U.S. Treasury are extending the deadline for… More »
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Omgeving Schiphol
Have you always wanted to work in the dynamic, exciting and challenging environment of aviation? Is safety your top priority and are you proud if the aircraft's you work on, are returned to our customers in time?
Then this opportunity is definitely for you!
As B1.1 and / or B2 Licensed Aircraft Maintenance Engineer:
- You independently perform inspections, troubleshooting, repairs and modifications
- You are responsible for releasing the work performed by yourself and the team assigned to you.
- You carry out the administration of the work carried out in accordance with the aviation regulations
- You are jointly responsible for the technical punctuality and fleet availability of our customers both at Schiphol-Center, Schiphol-East and at Outstations
- You lead mechanics and supervise the work carried out by them
- You participate in various improvement processes for more efficient maintenance processes
Our work environment:
- You will be employed in a dynamic company that is in full development with a lot of opportunities
- An inspiring and dynamic work environment with a daily variation possible between working Line Maintenance duties at Schiphol Center, Base Maintenance activities in our modern Hangar 73 at Schiphol-East, with modern schops and ad hoc AOG recovery business trips to Outstations make the work extra challenging
- The Hangar has been completely renovated and has modern facilities
- The atmosphere is informal and there is a constructive cooperation where just culture is participated.
- You get a personal iPad and very comfortable working clothes
- You get a type training (if necessary) and there are also training opportunities for personal growth and development
Job requirements
- You have completed relevant education at MBO 4 level
- You are in possession of an part 66 AML B1.1 and/or B2 Aircraft Maintenance License with preferably an Embraer 170/190-series or other aircraft type training
- You have knowledge of EASA law and regulations and extensive knowledge and experience within an aircraft maintenance environment
- You are customer-oriented, commercial and cost-conscious, able to improvise, to think in terms of solutions and possibilities
- You have a good command of the English language and preferably also in the Dutch language in word and writing and have at least basic knowledge of the MS Office package
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- Furthermore, you recognize yourself in the following competencies: Stress-resistant, flexibility, initiative, working in a team, interpersonal sensitivity, effective communication.
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- We provide full options for training & development
An assessment and/or capacity test can be part of the selection process.


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Turkey is a dazzling destination that straddles Asia and Europe. Its vibrant culture, famous food, and vast history wow all who venture here. Turkey Tourism is focused largely on a variety of historical sites, and on seaside resorts along its Aegean and Mediterranean Sea coasts.
There are so many places in Turkey as declared as UNESCO World Heritage Site or City and they are all spread all around the country.
Turkey has also become a popular destination for culture, SPA, and health care. Whether you want to laze on the beach, delve into history wandering through ruins such as Ephesus, lap up the Byzantine and Ottoman glories of Istanbul on a city break, or see some of the world's most surreal panoramas in Pamukkale and Cappadocia, this country has attractions galore.
Here are some of the best destinations you should consider seeing when you come for your hair transplantation.
Istanbul is the only city situated on two continents in the world. Sultan Ahmed Mosque (the "Blue Mosque"), the Hagia Sophia, the Topkapı Palace, the Basilica Cistern, the Dolmabahçe Palace, the Galata Tower, the Grand Bazaar, the Spice Bazaar, and the Pera Palace Hotel all in Istanbul.
Istanbul has also recently become one of the biggest shopping centers of the European region by hosting malls and shopping centers, such as Metrocity, Akmerkez, Kanyon and Cevahir Mall, which is the biggest mall in Europe and seventh largest shopping center in the world.
Other attractions include sporting events, museums, and cultural events. For every season in Turkey, you can find a place to visit, and shop.
Come and see Turkey.


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|May 5 - May 7
|Mariposa Butterfly Festival
|Learn about butterflies, while they tickle your hand and remind you of the wonderment of youth.
|Mariposa Butterfly Festival
|May 27
|Art & Wine Festival
|The Mariposa-Yosemite Rotary Club presents the 13th Annual Art and Wine festival on the Mariposa Courthouse lawn. Saturday of Memorial Day weekend, 11:00 am to 5:00 pm.
|Mariposa Art & Wine Festival
PING PONG - On site
HIKING - The Stockton Creek Reservoir Trail is a 5-mile loop through the
Sierra Foothills (5 min. walk to the trailhead)
TENNIS - 3 courts at the Mariposa County Park (10 min. walk away)
CALIFORNIA STATE MINING & MINERAL MUSEUM - Gems, mining
artifacts and other exhibits. (5 min. drive away)
California State Mining & Mineral Museum
MARIPOSA MUSEUM & HISTORY CENTER - The museum's mission is to
authentically portray the people and lifestyle of Mariposa County from the
Native American and Spanish periods to the California Gold Rush and
through the early 1900s. (15 min. walk away)
Mariposa Museum and History Center
SIERRA ARTISTS' GALLERY - A cooperative gallery featuring unique art
and gifts from artisans of Mariposa county, the surrounding Sierra foothill
area and Yosemite National Park. (5 min. walk away)
Sierra Artists' Gallery
TREETOP GALLERY - Sponsored by the Mariposa County Arts Council, the
gallery features the work of local artists, serves as a creative community
center, and is a resource for emerging and established regional artists.
(10 min. walk away)
Mariposa Arts Council Treetop Gallery
RAFTING - 3-mile trip on the Merced River in Yosemite Valley (1 hr. drive away)
Yosemite Rafting
YOGA - Regular classes Tuesday - Friday, private instruction available by
request (20 min. walk away)
Mountain Yoga
YOSEMITE ZIPLINES - (5 min. drive away)
Yosemite Ziplines and Adventure Ranch


text:
Download: Edulis Nursery Galanthus availability list 2020 | Fern Availability 2020.
Send us a list of the plants that your are interested in by adding them to your Shopping List. We'll respond as soon as possible to let you know what's in stock and the total cost.
A statuesque grass for the back of the border. Lush green leathery grey-green leaves. Rarely flowers in the UK. Perfectly hard with us. Cut down in spring.


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"To believe with certainty we must begin with doubting." ~Stanislaus I of Poland
What is that Stanislaus trying to convey ?
He says, to be certain you have to be doubtful !
First of all if you decided to believe in something ,why should you be doubtful or apprehensive ? Are you not sure of yourself ?
Is this a contradictory statement or it is a perfect statement ?
Readers please enlighten me further with your thoughts.


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Separate names with a comma.
By KiiWii, Jul 27, 2011
48,485 271 0
New expliot, coming soon:
(8hrs ago)
Looks awesome (and easy)! I hope that they save it until after the next firmware update, though. You know Nintendo will issue one before Skyward sword and it's been a long time since the last update anyway.
Nooooo! My Indiana Pwns game will soon be worthless!
Oh well, this is the price of progress.
Well, if hacking becomes this easy, I will certainly buy a Wii!
(8hrs ago)
Simply Awesome...!
perhaps if you email/twitter/paypal him he will email your Wii the exploit directly
Ok but this exploit is mine after Lol . I dont have his email.
Its awesome the giantpune, crediar works.
he will email your Wii the exploit directly ????
Im exciting giantpune !!
You have banner bomb, twilight hack ,and now Mailer Bomb email gift XD
great! the replacement of bannerbomb for 4.3 firmwares
He's soo right
Im agree.
good good
soon i may hack my wii
looks like you can just run the HBC from normal menu then?
well can't see him making that much money on this, seeing the damn pirates will get it (only need one of them). then it will be all over with this exploit.an it would become as worthless as the games. unless he some how,adds the wii's numbers (lu64+++) to the exploit. so it only works for the person who pay's for it. i would buy it, if my wii hadn't been hacked before.
I honestly don't believe they will charge for this, I think Pune was joking.
[Just saw pune check this thread out, hopefully he will shed some light]
well i got a virgin Wii
would love to know if would work on it and what else i would need to install
Where is Giantpune ?
New Homebrew Channel Mail Portable.
Great news, pune.
It came just in time. I have at home a wii that has its laser damaged and can´t crack it using Lego Indiana Jones, since the game crashes, which is very frustrating, since the game is very hard to find in my country
Any idea when this will be publicly available?
No release date yet.
Please name it Mail Bob-omb!!!
Lol Good Name


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limited edition red cypress incense
This is a limited edition incense handcrafted by a small incense maker in Malaysia. It is a blend of white sandalwood with red cypress 紅心柏. The red cypress is sourced from a giant red pine that lived at a famous local monastery known as Ang Hock Si 洪福寺 in Penang, Malaysia. In 2018, a severe thunderstorm resulted in this tree topping over and unfortunately it could not be saved. The abbot of the monastery allowed for it to be processed into this special limited edition incense. This incense certainly carries lots of blessings from generations of pure practice and prayers at the monastery!
- 35 sticks, each burning for approximately 35 mins
- subtle, soft, calming & soothing
- comes in a beautiful tube incense case
- handmade, natural, non-habit forming