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Some YouTube users have recently discovered they are now unable to monetise certain videos after the video-sharing platform updated its rules on advertising on 31 August 2016.
Reading the rules might not give you a clue, as the change is not really in the policy itself – it is about YouTube notifying content creators to what it considers inappropriate content. Creators will now receive emails about videos that have been demonetised.
Its begun pic.twitter.com/7xc30WaIfZ
— Spazkid (@Spazkidin3d) September 1, 2016
Content that is considered "not advertiser-friendly" includes, but is not limited to:
- Sexually suggestive content, including partial nudity and sexual humor
- Violence, including display of serious injury and events related to violent extremism
- Inappropriate language, including harassment, profanity and vulgar language
- Promotion of drugs and regulated substances, including selling, use and abuse of such items
- Controversial or sensitive subjects and events, including subjects related to war, political conflicts, natural disasters and tragedies, even if graphic imagery is not shown
YouTube spokesman said in a statement: "While our policy of demonetising videos due to advertiser-friendly concerns hasn't changed, we've recently improved the notification and appeal process to ensure better communication."
As part of YouTube's new notification process, there will be three changes.
1. There will be a "$" icon in video manager that will appear as yellow with the words "Not advertiser-friendly" – to let creators know when a video has been demonitised.
2. YouTubers will also be notified via email their ad revenue has been suspended.
3. If YouTubers believe these claims to be unfair, they are able to appeal them.
YouTube states it will retain the right to not monetise a video, and could suspend monetisation features on channels upon "repeated breach of policy".
In response to the overwhelmingly negative backlash, the platform also releases a statement to point out that rules regarding monetisation are not new, but have been installed since 2015. In which the YouTube community is still very not happy about it.
Youtube: This isn't a policy change, its just a notification/appeal change. Me: So before you were just turning off ads and not emailing us? — Philip DeFranco (@PhillyD) September 1, 2016
In fear of the censorship issues YouTube can potentially raise, hashtag #YouTubeIsOverParty has made headlines on Twitter.
YouTube's new update means ads are disabled on my acne videos because advertisers don't like it. Seriously @YouTube? pic.twitter.com/DoMokuvJvn
— Melanie Murphy (@melaniietweets) August 31, 2016
YouTube disabled ads on my DEPRESSION video cus advisers dont like it. Sorry depression isn't fucking pretty enough… pic.twitter.com/YXs0YFGVAb
— luke cutforth✨ (@LukeIsNotSexy) August 31, 2016
why won't they just make a children's mode for youtube instead of censoring content everyone else wants to see #YoutubeIsOverParty
— mafalda (@raindcwn) September 1, 2016
#YoutubeIsOverParty This thing would take away a lot of the creators creativity and freedom, a big part of what makes yt great for nothing! — DanaLovatoHoranHemmo (@Danathefangirl) September 1, 2016
In fact, the updated regulation is becoming an issue raises additional questions. How many creators were ever aware that their videos had been demonetised before the announcement? How many videos on the site does YouTube's algorithm deem unfriendly for advertisers? And most importantly, where should the line be drawn for advertiser-unfriendly content?
None of these queries have been answered yet.
Jenny Li, general manager at VS Media, agreed the lines were blurred, but suggested that "youtubers would have a sense on what not to talk about."
"The content policies are here for long, and the executions have been quite consistent," she said. "Youtubers usually get an alert when they break the rules, so past practices may had made it clear."


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Little Late notice, but some of us have decided to hit the Badge trails at Redbird here indiana! There are (4) trails I believe. We are going to try and be at the park between 9-930 on Sat 11/16/19
If anyone wants to come along more the merrier!! hahaha. This isnt an official club or anything like that so there are no rules and you are responsible for your on rig. So if your stock and you think you can make it come on out. hahaha
If you dont we can always wheel the other trails and have a good time~

subset: commoncrawl


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Building Community Where You Live And Work
Enabling Foundation and Nonprofit Professionals to Connect, Gather, and Build Community
ComNetworkLOCAL focuses on building relationships where you live and work, with folks who work in comms for good, local nonprofits, foundations and practitioners, with the local community and among The Network.
LOCAL groups build and deepen a sense of community by building relationships and a local support network. You can expect LOCAL gatherings to focus on community, connection, learning from each other, with the goal of building the next generation of leaders in the social sector.
Why Gather:
- Gathering builds relationships
- Connection and relationships build support and community
- Community drives change
How is ComNetworkLOCAL Different?
ComNetworkLOCAL is different than other professional gatherings that focus solely on learning a new skill or lecture style events, because LOCAL groups focus on building your support network. The goal is for you to come back to gatherings and continue to get to know your social sector community on a deeper level.
What LOCALs Are and What They're Not
- LOCAL gatherings aren't about fancy food or flashy speakers. Hosts build relationships through discussions, in-real-life connections, introducing and connecting people.
- LOCAL gatherings are for people who want connection, and not sales pitches.
LOCALs are Led by Network Members, They are Open to Anyone
ComNetwork LOCAL gatherings are run by passionate volunteer Community Leads and their LOCAL Leadership Teams. ComNetwork HQ works closely with every Community Lead, and there is a formal application process to start an official LOCAL group in your area.
In order to be a LOCAL Leader you need to be a member of the network in good standing. But ComNetworkLOCAL events are always open to anyone, free of charge. The key audience is Network members—and folks in the social sector who are passionate about building community to advance the field and work of communications for good are welcome to attend.
We limit only one LOCAL group per city and recommend that LOCALs are based in cities and populous areas. We typically have LOCALs in cities with a population of over 500,000, but we are open to hearing why you think the social sector in your community could use a LOCAL group.
LOCAL groups are led by individuals who work in foundations and nonprofits. A company can't lead a LOCAL. In some instances, a LOCAL Leader's company supports their employees by donating space, covering the costs of snacks, etc. But at the end of the day our official relationship is with the individual, and if that person leaves his/her current role, the LOCAL group would remain with that person.
Interested in starting a LOCAL in your city?
If you have read through the above info and meet the following requirements, please reach out to Carrie email@example.com to talk more.
Each ComNetworkLOCAL needs to have the following:
- One dedicated Community Lead who works at a foundation or nonprofit, who volunteers to oversee the LOCAL Leaders Team, and is responsible for making sure 4-6 gatherings happen a year.
- A dedicated LOCAL Leaders Team made up of 3-7 people in the social sector who commit to attending, planning, and hosting 4-6 gatherings a year
- We recommend each gathering have a minimum of 6-10 people so we ask that you feel out your community to see if you'll be able to pull in enough people consistently for a LOCAL gathering before launching


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|This article as .pdf
Taking Prussia for a walk
The federal state of Brandenburg advertises itself with the motto: »Dieser Weg ist das Ziel« (»This path is the goal«). The Radio Eins station has collected further slogans from its listeners. »Dieser Weg ist das Ziel« has only 19 letters and is therefore said to be quick to grasp. »Tja«.
»Taking Prussia for a walk« is my association on podcasts by and with Judith Holofernes. Anyone who has heard the songs she wrote with the band »Wir sind Helden« knows that they contain happy and thoughtful notes about the Prussian work ethic, about endurance, about being carried and about going for walks. Her podcasts under the title »Salon Holofernes« can now be found on Patreon for little, well-spent money. I listened to them during a short trip to Brandenburg.
Only the name Judith Holofernes disturbs me every time. Of course, art can, should, must unsettle, childhood and youth as well, antiquity anyway. Ask Kafka or Kleist. One may know Theodor Fontane's rather not unsettling »Wanderungen durch die Mark Brandenburg« (»Walks through the March of Brandenburg«). But those writers, did they too take Prussia for a walk?
This time I was at the Stechlinsee near Rheinsberg. Stechlin like Slavic steklo – glass. It is unknown whether the name refers to the crystal-clear water of the lake or to the glass-makers who heated their ovens for centuries here, where there is plenty of sand and wood. The name Rheinsberg refers either to the Lower Rhine, from where settlers came here in the 12th century, or to the running and flowing of water. This origin also remains unclear. A melting in many ways, from the melting of the last ice age onward, that shaped this landscape 12,000 years ago. Between the Stechlinsee and Rheinsberg lies the Nehmitzsee. Its name is derived from the Slavic word for »mute«. Tja.
There was a time before Prussia and now is the time after. For now, Prussia remains an inner state for me. I want to summarise this state as the compulsion to pursue goals with all my strength, the consequences of which I will never be able to think through completely. Asking questions is allowed, as long as the asking is serious work. What must not be is tiring, giving up. Then others would win. Who these others are remains yet another question. But it is clear that the descendants of Protestants cannot simply stop protesting. Only Christ, only through Scripture, only through grace, only through faith. »Explain to me work«.
As if everything that stayed still in one place ran the risk of sinking into the swampy, sandy ground and freezing to ice again. So should I not occupy myself with the writings of Thomas Mann before I continue writing here? Until 1924 psychological insight and perceptiveness dominated in his work. Even the attempt to think about Prussia is probably still a Prussian quality.
Brandenburg has no doors and windows. Saxon Switzerland has pierced rocks and the Malerweg (Painter's Path). In Dresden, on the »Balcony of Europe«, there is an empty window frame in memory of the painter Caspar David Friedrich. The Brandenburg landscape does not need the view into the distance, it needs no frame. Here the images merge, melt, never stop, www.bezgranic.eu redirects to www.ohnegrenzen.eu, the red eagle refers to the red rooster.
The red eagle is the Prussian heraldic animal. It goes on a drive on the seal of every vehicle registered in Brandenburg. »Steige hoch, du roter Adler, über Sumpf und Sand…« (»Climb up, red eagle, over swamp and sand…«) In his novel »Der Stechlin« Theodor Fontane sets the red rooster to its side. The red rooster rises less often. Recently it is also available in the form of a footprint. In the flat Brandenburg landscape the movement of footprints is predominantly horizontal.
»We should love everything old, insofar as it is entitled to, but we should actually live for the new.« I have laid out this Fontane sentence as my guideline and my attitude for the coming technological, social, political changes. This sentence is tautological. What we live for can become the new. And the joke with Fontane and the binary tree is a good one.
Is aimless and unintentional walking on words or on feet a counterweight to the inner Prussia? Can Prussia become more intelligent, more creative, more human if we internalise it and take it for a walk through Brandenburg? It is worth trying. »For the sake of this task, to preserve at least shame for mankind, Kafka sometimes found back to a kind of ancient joy.« Giorgio Agamben in »Idea of Shame«. Perhaps this will »make our roots wide«.


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- September 9-25: The Puyallup Fair, largest single event held in Washington each year; among the top ten fairs in the world
- September 22, 7:30pm: The Golden Age of Ingmar Bergman Film Series presents The Virgin Spring at Seattle Art Museum.
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Your event here: add or edit events
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Docker solution is designed for comfortable application distribution using fast and lightweight templates, which allows running your projects almost everywhere. Thus, it is a perfect technology for for those developers and sysadmins, who look for speeding up the application delivery workflow and avoiding the constant adjustment issues.
In order to handle your own Docker image, the appropriate registry is needed. The vast majority of dockerized solutions are stored at public registries so that anyone can use them. However, sometimes, it becomes necessary to hide your repository content from the rest of the world, e.g. in case it contains some proprietary code or confidential information. For this purpose, you can create your isolated private registry.So, let's discover how to get it at Jelastic platform in a matter of minutes through following the next steps:
Subsequently, you'll be able to easily deploy the added image from your private registry to Jelastic PaaS.


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RaceChick.com Sponsors 2020 Car Chix Calendar
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Two state-trait discussions on happiness: A reply to Stones et al
ABSTRACT<br/> Rejoinder to reaction by Stones et.al. (SIR 36) on Veenhoven's "Is happiness a trait?" (SIR 32). It is argued that the criticism pertains to another issue, another concept of happiness and another notion of trait. The initial question was whether a better society breeds happier people, and concerned fixedness of the 'absolute' happiness-level. The criticism is about permanence in 'relative' happiness-rank. These are different things: constancy in happiness-ranks in a population does not imply that average happiness-level remains the same. The question concerned happiness in the sense of life-satisfaction. The critics conceive happiness as a broader 'personality' syndrome. Personality may be fairly invariant, but the question was whether life-satisfaction is. The initial notion of happiness 'trait' was quite specific, and concerned a disposition to judge life positively or negatively. The critics refer to 'trait' as continuity in all personal characteristics, including health. Again that is an other matter, with different implications for the question at stake. The criticism is framed in notions of psychological personality research. That approach may bear relevance for the question whether differences in happiness can be reduced. Yet it is not appropriate for answering the question at stake: that is, whether it is possible to raise the
|Additional Metadata
|happiness, life satisfaction, personality, set point theory, state, subjective well-being, traits
|Persistent URL
|dx.doi.org/1006867109976, hdl.handle.net/1765/16325
|Social Indicators Research: an international and interdisciplinary journal for quality-of-life measurement
Veenhoven, R. (1998). Two state-trait discussions on happiness: A reply to Stones et al. Social Indicators Research: an international and interdisciplinary journal for quality-of-life measurement, 211–225. doi:1006867109976
|Additional Files
|1006867109976.pdf Final Version , 65kb
|publisher's version Final Version


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Choosing the right attorney — Hawaii Lawyer Today's Story
"You can't do that" the Prosecutor told me, but I expect her to say that. She gets paid to say that. Exasperated, but not obnoxious.
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Zachary Tavlin, University of Washington, USA
Zachary Tavlin is a Ph.D. candidate in English at the University of Washington. He received his M.A. in Philosophy from Louisiana State University, and his B.A. in Philosophy from The George Washington University. His areas of research include the history of philosophy, film, and 19th and 20th century American literature. He has published on Augustine and Lacan's philosophies of language and the films of David Lynch and Krzysztof Kieslowski. Forthcoming publications include essays and book chapters on the fiction of Don DeLillo, the films of Hal Hartley, Heidegger and Cormac McCarthy, Ashbery's poetry and object-oriented ontology, and the television programs Northern Exposure and The Simpsons.
Članci istih autora
|Naslov teksta
|Sleep and Insomnia in Levinas and Shakespeare's Henry IV
|Broj 1 / Godina 5
|Književnost i kultura


text:
Anyone here with experience using the puppet sensu module?
I want to use the puppet sensu module to install and manage my sensu but am having problems with trying to add handlers and/or checks.
A while back I re factored my whole puppet environment to use Hiera and I am starting to believe that this may be the reason why I cannot get them to work. However I do not know a way to fix it.
I have followed the documentation online and have tried adding the handler to my node but I always fail.
node avatar-mon01 {
sensu::handler { "default":
command => 'mail -s "Test" email@example.com',
I also tried adding it directly to my site.pp file with the same result.
Error: Failed to apply catalog: Could not find dependency File[/etc/sensu/conf.d/handlers] for Sensu_handler[default] at /etc/puppet/environments/qa/modules/sensu/manifests/handler.pp:144
Checks are pretty much giving me the same problem just stating that they could not find the dependency for checks instead of handler.
Error: Failed to apply catalog: Could not find dependency File[/etc/sensu/conf.d/checks] for Sensu_check[diskspace] at /etc/puppet/environments/qa/modules/sensu/manifests/check.pp:120
Anyone have any ideas how I can set these up using hiera? I do not want to have to recreate the my own hiera version of sensu.


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After obtaining a green card the Duke would be eligible to apply for full US citizenship in three years
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Exercise Cygnus dramatically exposed the gaps in Britain's pandemic response but its 'terrifying' findings have yet to be published


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|Capital City
|Official Language(s)
(4,369 days old)
|Government Type
|Nation Team
|Statistics as of 10/02/2010
|57,235 civilians
|Literacy Rate
|Nation Strength
|Nation Rank
|2,965 of 5,242 (56.56%)
|Total Area
|Native Resources
|Rubber, and Uranium
KitKatLand is a medium sized, well developed, and aging nation at 372 days old with citizens primarily of Japanese ethnicity whose religion is Shinto. Its technology is first rate and its citizens marvel at the astonishing advancements within their nation. Its citizens pay extremely high taxes and many despise their government as a result. The citizens of KitKatLand work diligently to produce Uranium and Rubber as tradable resources for their nation. It is a mostly neutral country when it comes to foreign affairs. It will usually only attack another nation if attacked first. KitKatLand is currently researching nuclear technology for the use of nuclear power plants but believes nuclear weapons should be banned. The military of KitKatLand has been positioned at all border crossings and is arresting all drug traffickers. KitKatLand allows its citizens to protest their government but uses a strong police force to monitor things and arrest lawbreakers. It has an open border policy, but in order for immigrants to remain in the country they will have to become citizens first. KitKatLand believes in the freedom of speech and feels that it is every citizen's right to speak freely about their government. The government gives foreign aid when it can, but looks to take care of its own people first. KitKatLand will trade with other nations with questionable ethical treatment of their citizens but prefers to keep such trade agreements a secret.
History of KitKatLand Edit
After the events of World War 2 Britain faced troubling times, with a manufacturing industry concentrated soley on producing weapons of war. Food products in particular were having a hard time recovering, due to the increased cost of converting their factories. Cross & Blackwell, famous for Branston Sauce, were suffering but Chocolate giant Nestlé saw the company as an opportunity.
Nestlé considered this an in-road into Britain, and a way of gathering more business. In subsequent years, Nestlé bought Leyland Motors as well as other top car manufacturing facilities. They also bought 90% of the fighter plane facilities in the country, in a bid to control manufacturing. By 1960, Nestlé had top politicians in all parties and in 1965 the company succeeded in gaining control of the UK government.
Nestlé knew that this was a particularly risky plan, and therefore had to come up with some way of winning over the population of the country. In 1966, the England football team won the world cup by defeating Germany. It is only now, 42 years later, that the world has realised that Nestlé infact fixed the entire competition so that England won. Nestlé sponsored the team and offered massive bonuses to the players as incentives. The public were told of this, and encouraged them to buy limited edition KitKat bars having aquired the brand from Rowntree in 1954.
Little did Nestlé know that the brand of KitKat would become the face of Britain in subsequent years. The CEO of Nestlé, back in Switzerland, decided that it's HQ should move to London. By 1975 Nestlé controlled and produced most of Britain's food stock, and also become the biggest food exporter in the world. Despite this, Kit Bischof CEO from 1969, wanted more and decided to take the sovereignty of the United Kingdom and make the country into a Capitalist state, ruled by the CEO of Nestlé.
Kit Bischof decided that the CEO should have a new name, and all subsequent leaders are called 'KitKatFox', for the duration of their term.
KitKatFox and CN Edit
- Joined United Sovereign Nations on the day of nation creation
- Reached member status
- Joined The Brain in November 2008
- Reached Minister of Foreign Affairs and Minister of Economics
- Joined Wolfpack on 17/1/2010
- Reached member status
KitKatLand has fought in two wars during its lifetime, in the GATO-1V war for USN, and in the TOP-CnG war for Wolfpack.


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One way to prevent the E-Commerce Black Hole is to provide a medium for buyers to communicate with experts, friends, family and coworkers as part of your checkout. Making this channel available nurtures Social Commerce, user contributions to assist online buying and selling of products and services. Users who can complete checkout, pending approval from those they would otherwise leave your site to seek out, beforehand, check out the first time and never enter the E-Commerce Black Hole.
Users who can complete checkout with a Social Commerce option avoid the Black Hole. Their purchase is approved afterward by the ones they would otherwise have to leave your site to ask. They can buy the first time they visit your site. They will be confident that if their social or expert circle doesn't approve the purchase, they won't have to return the item or cancel the purchase.
Social Commerce prevents the E-Commerce Black Hole by not only preventing your customer from ending up there, but the right Social Commerce platform can provide insight into many of the questions asked in the E-Commerce Black Hole and answers to other issues previously addressed outside of your retailer range.
Social Commerce gives us the ability to respond to questions like this:
- Who are they talking to?
- What are they saying?
- When will they buy?
- Where will they buy it?
- Why are they waiting?
Social Commerce lets us dig deeper, too, learning:
- Who are my future customers?
- What will future customers buy?
- When will these referrals return?
- Where will these references look when they have a similar need?
- Why didn't I embrace Social Commerce sooner?
I like that last one best. Why don't you embrace Social Commerce?


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Aaron Stevenson
Aaron Stevenson has worked in the mental health industry for over three decades, across nearly all facets of psychiatry, mental health, counselling and treatment. After graduating from Psychiatric Nursing studies, he's since gone on to earn a Graduate Diploma and a Masters in Mental Health.
Working mostly in hospital emergency departments, Aaron has seen firsthand just how disruptive and damaging relationship breakups can be to peoples lives.
Despite being an expert in human behaviour, it was only after experiencing his own relationship demise that he discovered how little practical guidance there was available, especially with a focus towards how males process relationship breakdowns.
While researching and exploring options for his own situation, the seed for The Secret Art of Breaking up was planted because despite an ocean of information, there was no practical, straight forward, step-by-step manual. A guide of what to do and what not to do.
"I wanted to understand what was happening and how to identify all the feelings and emotions I was having," Aaron says.
"I reviewed and researched hundreds of relationship articles, websites, podcasts, ebooks, forums and groups. My goal was to take the most pertinent, distinct and useful elements and apply them to my 32 years of clinical and now lived experience."
"It became a method to understand the process, but also to survive the process."
In the process of writing the book, he was convinced to keep working on it after a number of people turned to him to help with their own relationship problems.
Now, years later, Aaron has combined his own experiences, research and training together for The Secret Art of Breaking up book and coaching sessions.
A proud father of two young boys, when Aaron isn't working or coaching you can find him travelling, watching movies or tinkering with his much loved home in regional Victoria.


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Stringray phone tracker use in the UK admitted for the first time
The Scottish Prison Service has been jamming calls with the devices.
Supreme Court dismisses appeal based on warrantless phone search
The Supreme Court has declined to hear an appeal filed by a convicted robber. (The appeal was based on the fact that his cell phone data was obtained without warrant and used as evidence in court.)
A newsletter a day keeps the FOMO at bay.
Now available on your smart speaker and wherever you get your podcasts: Apple Podcasts | Spotify | Google Play | iHeart Radio
Now available on your smart speaker and wherever you get your podcasts: Apple Podcasts | Spotify | Google Play | iHeart Radio
The IRS has used Stingray phone-tracking tech
The IRS is the 13th known US government agency to use Stingray technology.
Mango kills Microsoft's always-on location tracking, makes good on letter to House of Representatives
Remember all that iPhone tracking hubbub back in April? Sure you do -- you probably also recall A...
Apple iCloud and iWork beta for iOS hands-on
We've had a few weeks to get accustomed to iOS 5 and Mac OS X Lion, but one headlining feature ha...
Microsoft outlines WP7 tracking policy, promises to cut it out
Microsoft has managed to avoid a good deal of the heat surrounding the smartphone tracking freako...


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|Relationship Status:
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Views: 231
And in this article I will give you guys an introduction, and also some extra tips on what I learned about.
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Respond faster to urgent messages from your clients
Previously, when you received a Secure Message, you could either see it directly in your SimplePractice account or you'd get an email if you weren't logged in. Now you can opt to receive a push notification on your mobile phone and respond in a timely manner directly from your SimplePractice app. Just tap on the notification, and your app will open, so you can send an immediate response.
Customers love using Secure Messaging to communicate quickly with their clients and their teams. We already showed you how Secure Messaging is much safer and more convenient than email or texting. Now you can receive a push notification, then send and receive secure messages from your mobile app. This great new feature is only available with the latest release of the app, so be sure to update your app and start receiving push notifications for priority messages today!
And remember, with our HIPAA compliant mobile app, you can also manage your schedule and clients, take notes, and add payments on-the-go.
Your daily tasks, streamlined for mobile.
Create, edit, and update appointments and client info between sessions. Send your client intakes, share invoices, and record payments with ease.
Your notes, when you need them.
Add progress or psychotherapy notes quickly using your phone's dictation feature.* You can even take a photo of a client's insurance ID card (or anything else!) and upload it directly to their file.
*While notes created in the SimplePractice app are secure and HIPAA compliant, some integrated dictation softwares may not be. Make sure to check that your phone's dictation tool is HIPAA compliant before using it to take notes in the mobile app.
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Don't Have an Account? Sign Up to Save Favorite Listings, Save Searches & More...
This home will not disappoint! With the HUGE 1.93 acre lot to beautiful finishes throughout. This home will have a beautiful brick and shiplap fireplace with LVP in living areas, Tile in wet areas, and carpet in the bedroom. The master bedroom has his and her separated vanities as well as 2 LARGE WALK IN CLOSETS! The Master bath will also have a beautiful large tub and tile shower.
This beautiful home is expected to be completed in February 2020
Can still pick out some finishes now
Information Source: Lee County Association of Realtors®
IDX information is provided exclusively for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing, and that the data is deemed reliable but is not guaranteed accurate by the MLS.


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The Cave FHS is grateful to Gordon Seyffert who has supplied information on American WW2 casualties.
Name: Lt. Elmore "Kelly" Cave, Jr.
- Born 2 Jan. 1916, son of Elmore Cave, Sr. (1872-1934) & Florine Brown (1885-1973), gr-s/o Rev. Robt. C. Cave & Sarah Frances Daniel
- Died 16 Sept. 1944 at Bodney, England – 2nd Lt., 787th Army Air Force Bomber Squadron
- Burial 28 Oct. 1948 at Valhalla Cem., St. Louis County, Missouri, U.S.A.
Source #1: http://www.web-birds.com/8th/466/466th.html
In 1938, he received a scholarship from the Pennsylvania Academy of Fine Arts to study sculpture in Italy. He was unable to accept because of the war in Europe.
His death was classified as "non-battle."
US Military Aircraft Accident Report:
DATE: September 16, 1944
PILOT: Francis L Bell
CREW MEMBER: Elmer (sic) Cave, 2nd Lt, O-820717, 787BS (Copilot)
LOCATION: Bodnay (sic), Norfolk, England
REMARKS: Mid-air collision between two B-24s; fifteen killed
Source #2: St. Louis Post-Dispatch 1944 [KIA] (photo) Article 10/12 p3A, 10/21
Source #3: http://www.findagrave.com/cgi-bin/fg.cgi?page=gsr&GSiman=1&GScid=32067&GSfn=&GSln=cave


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VirtualBox is a virtualization solution known by individuals, because it's free. This virtualization solution can virtualize Windows, Linux and Mac 32-bit (x86) and 64-bit.
However, don't try to run a game in a VirtualBox VM, because it will probably not work.
For this, you should use a VMware solution.
ESXi (or VMware vSphere Hypervisor) is a virtualization server created by VMware and is based on the Linux distribution : Red Hat. Which is a Linux distribution oriented businesses.
VMware Workstation is a professional virtualization program that allows you to virtualize any operating system while having very good performance.
3 software displayed.


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Choose A Window Tinting Company You Can Trust
When choosing your window tint near Rothesay, visit a company you know you can trust to get the job done correctly. No matter whether you're looking to tint the windows of your car, office, or home, you'll find a variety of premier tint shades at your nearby location. Rest assured, our window tint is custom cut for your business, home, or car windows to ensure a perfect fit—always. Plus, it is manufactured to last, so you don't need to worry about the discoloration and bubbling that occurs with lower-grade window film. Choose to have your window film installed by our professionals and you could get the added security of a lifetime limited warranty. This warranty means that in the off-chance your office, car, or home window tint bubbles, fades, or become discolored, we'll remove and replace it free of charge.
Install window tinting for a cooler, more comfortable drive
Over an extended period of time, continued exposure to heat and sunlight can cause your car's seats, upholstery, and dash to crack, peel, and fade. LLumar window tints offer today's busy drivers awesome protection and value for their vehicle. Tinting your car windows means better shielding the interior of your car, plus your passengers, from the sun's troublesome heat and glare. Select from your tinting company's full assortment of vehicle window tint shades, ranging from translucent to dark charcoal. The level of darkness you choose will depend on your state's laws. Curious about your state's car tinting laws? Call or visit today to check out your options and to learn more!
Home window tint: Save money & protect your furnishings
When installed by one of our factory-trained technicians, your home window tint helps provides your family with protection from the sun's harmful rays, plus sometimes privacy from the prying eyes of strangers. Have the windows in your home tinted to help prevent the fading of furnishings, floors, and artwork by the sun. It helps ward off close to 99% of the destructive ultraviolet rays that cause unwanted discoloration and fading in your home. When it's hot outside, even unbearably so, it helps keep your house cooler and more comfortable. Many satisfied customers have reported seeing their energy bills decrease by up to 15% once their home window tint was installed! Since LLumar is LEED-certified, you could be eligible to save even more money through applicable tax credits and incentives in your area.
Commercial window tint: Conserve energy & convey style
Commercial window tinting could help lower your building's energy consumption while conveying a look that's both polished, professional, and overall stunning. Choose from a wide range of tint shades, from clear to deep charcoal. When installed by your LLumar dealer, non-reflective window tint provides a uniform look that blends seamlessly with the design of your building. Dual-reflective options are also available for companies that need a glossy exterior to improve solar heat rejection, but a less reflective interior for additional privacy in the evening. Despite what you may think, commercial window tint can be used beyond the exterior of a building. It can be used for style and privacy in conference rooms, stairways, and interior office windows too. Visit or call the professionals at a LLumar window tinting location near Rothesay today to get started on your next office tinting project!
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For quick, easy, and professional window tint installation, turn to your local LLumar company. In fact, many custom tint projects can be finished within a few days, depending on the size of your home, car, or business. For the most part, a typical installation takes around 15 minutes per window. Visit a LLumar window tint dealer for window tinting installation and service you can trust. From office to residential window tinting that requires clear, mirrored, reflective, or color-tinted films, we're here to assist you in selecting the right one for your needs. Schedule your installation today! Call or visit a LLumar installer near Rothesay to learn more about your window tint options and to get a free quote. Appointments fill up fast! It's time to improve your view of the world.


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Over the last few years, the popularity of CBD has expanded considerably. One of the reasons that society has taken so well to CBD is because it doesn't have any psychoactive effects. Essentially, you can enjoy all the therapeutic benefits of cannabis without getting high. CBD has become an integral part of pain treatment regimens for sufferers facing a variety of chronic pain-related conditions.
The amount of milligrams of CBD you should take depends on your specific reason for taking CBD. If you are using CBD to treat chronic pain, you might take a much higher dose than someone who would be using CBD for general wellness reasons. Google search for your specific condition or reason for taking CBD to find the dose that is appropriate for you. You can take CBD in high qualities, so feel free to test out different dosages and see how your body reacts. A standard dose of CBD is 10 mg once a day, but this varies so widely because each individual is different so this can't be taken as a recommendation for you.
Although CBD oil has been legalized in most states, tetrahydrocannabinol (THC) is subject to a very different set of restrictions. Like the CBD, THC is the cannabinoid that can be extracted from the cannabis plant. Although many petroleum products based on the CBD sell themselves as insulators and THC-free, the absence of federal regulations on these products means you can be deceived.
It is a natural supplement made from GMO-free hemp. The method used in extracting the hemp oil is supercritical and uses CO2. Tests are made for each batch to ensure that the concentration is accurate. Canolane Organic Hemp Oil Drops 5000mg is therefore green, safe, and of high quality. As full spectrum oil, Canolane Organic Hemp Oil Drops 5000mg contains essential vitamins like proteins, minerals, flavonoids, fatty acids, and terpenes.
San Francisco's Johnny Apple CBD assures customers that it only uses organic, non-GMO hemp plants for its CBD extract. In addition, the company declares, it's put the time and effort into ensuring the genetic quality of the raw material. Perhaps that rigorous process has helped Johnny Apple CBD in securing the often-superlative reviews given to its products, which have in total earned the company an "excellent" TrustSpot rating. Those duly tempted to purchase from the producer can take their pick from CBD oil blends specially formulated to encourage either tranquility, happiness or clear-headedness. Also available are a wax designed for dabbers, a cocoa butter "calm balm" and 99 percent-pure CBD in crystals – the finer variety of which, Johnny Apple CBD explains, is entirely suitable for adding to baked goods.
CBD American Shaman's extensive array of products ought to satisfy even the pickiest customer, ranging as it does from flavored tinctures to CBD-infused under-eye serum – and even, for horse lovers, an "equine ointment." Furthermore, its inventive, water-soluble hemp oil supplement means that users can get their daily dose of CBD just by quenching their thirst. They're all ways through which CBD American Shaman, as the website states, aims to "[bring] wellness to the world." The company has a philanthropic streak, too, with a pledge that it frequently gives to non-profit organizations, while its "Compassionate Care" scheme cuts the prices of its goods for those with long-term health conditions. Plus, the company asserts that it uses only organic, non-genetically modified hemp in the making of its CBD oil products, with no insecticides used in the growing process.
The above details illustrate the value of House of Healing Hemp Oil to our health. Apart from relieving pain and anxiety, it also contributes to the health of our heart system. Though not all people love the local flavor, many enjoy the taste. $59.99 is affordable for many people. As a result, House of Healing Hemp Oil is accessible. Among the best CBD oil on the market, it has won its place on the top. To experience the effectiveness of CBD oil, consider House of Healing Hemp Oil as a priority.
CO2 extraction is one of the most common ways CBD is extracted from the hemp or cannabis plants. This method uses expensive equipment that adjusts temperature and pressure to extract the cannabinoids from the plant material, without damaging them. The other common method is to use solvents like ethanol or butane to extract the plant material. These solvents have to be burned off the final product which may damage the cannabinoids or terpenes in the process. There is also a risk that these solvents may not have burned off completely and could end up in your end product.
At Google, "CBD Health benefits" contains articles that praise its healing properties, from pain relievers to anxiety, and studies examining its effectiveness in the treatment of neurological conditions such as epilepsy and multiple sclerosis of affirmations. It makes it an attractive option for athletes who want to relieve their weak muscles after their workouts, control their chronic pain, or reduce their stress during great races.
Hemp Oil 1000mg is a critical product in relieving chronic pain, stress, supporting mood and a healthy sleep pattern, and caring for the skin as stated above. Because of its useful results, it has not only earned itself the best CBD oil for anxiety and pain but also on the market. The fact that its legal and Colorado certified makes it popular with many people. If you are planning to buy a CBD oil, why not try Hemp Oil 1000mg.
Did you know that pain is the number one reported condition for medical marijuana cards in the U.S.? In Colorado alone, 92% of patients, over 86,000 people, use cannabis to treat their chronic pain. Research on CBD and pain management has shown great promise and people are increasingly turning to cannabinoid therapy as the harms of opioids garner more attention and scrutiny.
Arthritis is a painful condition that usually affects during old age. The pain could become excruciating and limits the movement. Allopathic treatments offer temporary relief from the pain as there is no cure for arthritis with the field of medical sciences. There are powerful natural remedies that can help you get rid of this ailment. One such natural remedy is CBD Oil.
The way NSAIDs work is by blocking the Circulating Immune Complex (CIC) activity in your body. CIC is a protein chain activated by your immune system causing pain, swelling, and redness to promote recovery. However, instead of affecting only the CIC around your pain, NSAIDs affect all CICs in your body, including ones that are necessary to maintain the lining of your stomach, intestines, liver, and kidneys. Long-term use of NSAIDs can result in more pain, stomach ulcers, kidney and liver toxicity, and leaky gut syndrome. Long-term they may lead to kidney and liver damage, intestinal bleeding, and even death (8, 9, 10, 11, 12).
There is a lot of anecdotal evidence that athletes use marijuana as a way to relieve stress and regain their effects. Ryan Vandrey, a professor at Johns Hopkins Medical School, is studying the use of Cannabis and cannabinoids in the treatment of health problems. The problem, he explained, is that the CBD has entered the market without any research that supports the drugs regulated by the FDA.
I've had experience with this method, and if you know what you're doing, skies the limit. But if you're a beginner and you want a long term strategy in place where you don't have to go out there and search for customers to join your platform and purchase from you, rather they come to you every single time, then my next method is one you should pay careful attention to.
CBD Wholesaling is an exciting business venture because it is a growing industry that has huge potential for growth and development. The CBD companies that had grown and become extremely successful over the years are proof that CBD products are making waves in the market, and they continue to thrive as more and more people discover their health benefits.
Over the last few years, the popularity of CBD has expanded considerably. One of the reasons that society has taken so well to CBD is because it doesn't have any psychoactive effects. Essentially, you can enjoy all the therapeutic benefits of cannabis without getting high. CBD has become an integral part of pain treatment regimens for sufferers facing a variety of chronic pain-related conditions.
Right? It's still hiding behind the curtains but it's becoming more mainstream each and every single day. And yes, one of the upsides is being able to make a profit from it. It's easy when you know what you're doing, but as a beginner, I can understand how difficult it might sound. It's when you get into the eCommerce side of things that it can be a bit more stressful at the beginning, but overtime it works well.
Did you know that pain is the number one reported condition for medical marijuana cards in the U.S.? In Colorado alone, 92% of patients, over 86,000 people, use cannabis to treat their chronic pain. Research on CBD and pain management has shown great promise and people are increasingly turning to cannabinoid therapy as the harms of opioids garner more attention and scrutiny.
The current level of growth in the CBD market is leaving most companies overwhelmed. Poorly run CBD distributors are not set up to provide a high level of service. As a result, many retailers find themselves dealing with delayed orders, missing product, and unreturned phone calls. As you choose a CBD partner, choose a company that has a level of service that leaves you feeling confident.
Commonly, cannabidiol known as CBD, it is a natural compound that has gained popularity among people all over the world for a variety of reasons. In this article, we discuss the advantages and disadvantages of CBD oil in muscle recovery. In this case, we will base our discussion on the positive and negative aspects of CBD oil for athletes/people with an active lifestyle.
In order to determine which companies were included on this best cbd oil list and how they were ranked, each prominent provider on the market (Note: we pulled our list of brands from other established and credible CBD rankings like: this one and this one.) was allocated six individual Rank Scores based on their performance in the following metrics:
For those unfamiliar with the different CBD products and their features and benefits, thorough information may be requested from the wholesale company. Most of these companies have designated product representatives who are more than willing to educate people who are interested in the products and can provide information about the different business opportunities.
Affiliate Marketing Entrance. Don't get me wrong, network marketing/MLM CBD oil selling is not bad but it's not that great like many people pump it up to be, that's why whenever I try to sell, it's through my affiliate marketing efforts instead. So what I did was create a funnel where people looking for a better opportunity can merge into selling cbd oil through affiliate marketing instead
Did you know that pain is the number one reported condition for medical marijuana cards in the U.S.? In Colorado alone, 92% of patients, over 86,000 people, use cannabis to treat their chronic pain. Research on CBD and pain management has shown great promise and people are increasingly turning to cannabinoid therapy as the harms of opioids garner more attention and scrutiny.
Product packaging is a great litmus test. How are their products presented? Are items sold loosely, or presented in boxes? Are the materials high quality? Is the packaging easy to display? Is the overall effect in line with other products in your store? Will it appeal to the customers you service or want to attract? Align yourself with a quality brand for the best results.
The Hemp Oil 1000mg is an omega supplement that naturally relieves chronic pain and inflammation. It also enhances better sleeping patterns and reduces stress and anxiety. One serving is equivalent to 40 drops and contains 36mg. Hemp Oil 1000mg is a full phytonutrient blend that gives an entourage effect. It contains flavonoids, phytonutrients, natural terpenes, and antioxidants. Hemp Oil 1000mg lasts roughly a month and contains omega, essential fatty acids and calming peppermint oil.
With Ultra High Strength Hemp Oil, you feel better naturally as it supports natural sleep, improves mental clarity, and relieves stress. The oil's production unit is registered with FDA and licensed in Colorado. It is also compliant with the batch record processes of GMP. Ultra High Strength Hemp Oil is legal in 50 states. 1 oz of 1800mg supports 60 servings.
The main thing that is inherently clear when scouting out FabCBD (which is a super new brand by the way that only just got started this year), is that they've made a pretty serious effort to develop a modern lifestyle brand. If you take a look at their website, everything from the web design to the brand labeling to the text they use screams modern and hip.
To be clear, there is no one specific test, scan, or anything else of the sort that you can do to determine whether or not you need CBD oil for pain. Also, since cannabis is not yet recognized by the FDA, you unfortunately can't really go to your doctor either and have them recommend it; until marijuana is FDA-approved, it cannot be prescribed by physicians.
CBD oil products needn't be expensive, as Canabidol proves. The company's pure cannabis oil drops, for example, sell from $28 for 10 ml, making them an affordable choice for new users still unsure about what CBD could do for them. That's not to say that Canabidol's goods aren't up to scratch, though, as the business aims to ensure their quality through both its own bespoke method of analysis and by sending its oil to third-party labs. Among the products on offer, meanwhile, are innovative CBD Gel-Tabs, which feature a specially developed slow-release system designed to improve the body's absorption of the active ingredient. And this, Canabidol claims, is "now the best-selling CBD cannabis oil product in the U.K."


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A female perched high in a tree, looking around and singing
Species: Purplish Jacamar Galbula chalcothorax
Author: Josep del Hoyo
Author: Josep del Hoyo
Thursday, August 30, 2007
Added to IBC: 18 Apr 2008 - 00:00
All Rights Reserved
Altitude (m):
227 meters
Load interactive map with all materials of the species or only this video
CitationJosep del Hoyo, IBC1162687. Accessible at hbw.com/ibc/1162687.
Extended version
Josep del Hoyo, IBC1162687. Video of Purplish Jacamar Galbula chalcothorax at Sani Lodge, Ecuador. Accessible at hbw.com/ibc/1162687.
Embed this video← Click inside, copy the code and then paste it into your web page code. Show me the embed as it will appear
© All Rights ReservedThis media published on the Internet Bird Collection is protected by Copyright.
It cannot be reproduced without the express written permission of the author.


text:
Jim's book corner library Integrated library system βeta
Bienvenue !
sur le catalogue de la bibliothèque "Jim's book corner" dont les différents ouvrages ont été offerts par Jim Mc Crate.
Pour les "amoureux" de l'auteur James Joyce, les ouvrages ont été offerts à une autre bibliothèque nommée "Anna Livia Plurabelle".
Le Jim's book corner se trouve au Labo de Langue de l'UFR STAPS, Allée Paschal Grousset, 80025 Amiens
Depuis cette application, vous pouvez rechercher un livre possédé par la bibliothèque et connaître son statut (disponible, emprunté, etc), lire ou déposer des témoignages dédiés à Jim et Christiane Mc Crate et consulter les évènements. Afin de bénéficier de toutes les fonctionnalités du site (gestion de prêts, réservations, etc), merci de vous inscrire dès maintenant.Je m'inscris » Déjà inscrit ?
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Dernier événement
Middle England or Le coeur de l'Angleterre by Jona Staps Language Lab le 14/02/2020 à 12:15
Middle England
CATEGORY: Fiction
Following the publication of Number 11 in November 2015, I was uncertain what to write next. But seeing Richard Cameron's stage adaptation of The Rotters' Club at the Birmingham Rep a few months later made me start thinking once more about Benjamin Trotter and his schoolboy friends, who would now be approaching their mid-fifties. I liked the idea of writing about them again, but couldn't think of a story strong enough. Then, on June 23rd, 2016, the British people voted to leave the European Union. I knew that I wanted to write something which would trace the undercurrents of anger and division leading up to this momentous decision, and it seemed inevitable that Benjamin, Doug, Lois et al should be the ones to help me in the task.
At the same time, I was aware that twelve years had gone by since publication of The Closed Circle, and there would not be too many readers who remembered the previous books well enough to be ready to plunge into a sequel. So I was determined to write Middle England in such a way that no prior knowledge of the characters was necessary.
In any case, I wanted to focus mainly on the younger characters: in particular Sophie, Benjamin's niece, and her husband Ian. Telling the story of a young couple who disagree about almost everything but must nevertheless find a mode of living together seemed an obvious way to dramatise the fault-lines running through modern British society.
Unlike most of my previous novels, Middle England does not really have a 'plot': it merely follows the outlines of recent British history – beginning with the election of the coalition government in 2010, ending in the aftermath of the Brexit referendum – and finds parallels between all the major, landmark events and developments in the personal and family lives of its disparate characters. This made it an easier and more relaxed book to write than many of its predecessors, and I finished it quickly, in about ten months. Re-acquainting myself with Benjamin and the others was like meeting old friends after a long absence, and I hope that readers share the same feeling.


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Kolorful – God & The Fam
God over money, money over bitches…" Kolorful chants over a hype MayniaC Beatz production & gives fans a sneak preview for those anticipating some new summer music. "God & The Fam" has the rapper unloading some issues & getting his talk on, showing hunger & letting everybody know he's gonna stick to playing his position in this game. Expect more new music from Kolorful soon.
"DON'T STAND TOO CLOSE VOL. 1" Junii
Detroit Emcee Isaac Castor "Rabbit Hole" Album Prod By Foul Mouth & First Single
The Rabbit Hole is the first full-length collaborative effort from Middle Finger music representatives emcee Isaac Castor and producer Foul Mouth. Recorded over the span of 2019, the project fuses hard hitting boom bap drums with an even distribution of psychedelic rock and Motown soul samples. This album is likely Isaac's darkest work yet, with lyrics touching on drug addiction, mental illness, and failed relationships. Take a journey down the Rabbit Hole with Isaac and Foul when the album drops on 4/20/20. The First Single is "Rabbit Hole (99 Bottles) Avaiable Now!
The Davis Way Presents: Visionary
The Davis way is pretty consistent when it comes to releasing projects, Visionary is the 7th project from his Architect Entertainment brand. This project features Mr. Furious, Supaemcee, Yung Profhet, 3269 Chise, Leaf Erickson, Ty Farris, John Cloud, Tru Klassik, Vstlez, Finale, Josef Coney Island, Ms Carmen, and Uncle P
T-Henn ft. Booster – "Good Vibes" (Official Video)
Neisha Neshae "Things Change" Produced by Heizenburr
"The Ruler is Back" by Supa Emcee
"DON'T STAND TOO CLOSE VOL. 1" Junii
Detroit Emcee Isaac Castor "Rabbit Hole" Album Prod By Foul Mouth & First Single
Lazarus – "Coronavirus Freestyle Part 1 & 2"
FROSTiSRAD – "insecure"
Clear Soul Forces Deliver Farewell Album " Forceswithyou".
Kid Vishis – Live From Heaven 2 (Produced By: Royce 5'9)
Apollo Brown – "365" feat. Ro Spit, Nametag, & Ty Farris
T-Henn ft. Booster – "Good Vibes" (Official Video)
Neisha Neshae "Things Change" Produced by Heizenburr
"The Ruler is Back" by Supa Emcee
Marv Won — Lenny Cooke (Official Video)
AGiLE SOCiETY – MASTER (Official Lyric Video)
MUSIC VIDEO2 months ago
Royce da 5'9″ – Overcomer (ft. Westside Gunn)
EVENTS3 months ago
Lazarus Joins GZA For A Legendary Performance January 28th, 2020 at El Club, Detroit
FEATURED2 months ago
Lazarus – "You Already Know" ft. Rick Ross & Gucci Mane
MUSIC VIDEO2 months ago
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FEATURED3 months ago
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FEATURED1 month ago
Lazarus – "Break The Walls" ft. Lady Legha
EVENTS2 months ago
Dillatroit 5 Feb 9th 2020 at the Marble Bar
MUSIC5 days ago
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text:
Need to auto populate value based on the value of related field? For this requirement Auto Populate is the perfect solution. The advanced configuration tools allow you to clearly define what should happen whenever a related field value changes.
Other add-ons of interest
Analytic Reporting Tool Basic
Dynamic Reports and Interactive Charts.
Powerful tool for SuiteCRM report creation and data analytics. Includes a variety of chart types, detailed, summary and pivot tables. This Reporting Tool is for anyone, no need for technical knowledge or SQL. Comes with over a hundred prebuilt reports.
SuiteCRM Calculation Field
Create business logic for field calculations without needing to write custom code. You can select calculated field and create the formula that is automatically updated based on calculation you provide.


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Nanotechnology. 2017 Jul 7;28(27):275601.
Coordination polymer nanocapsules prepared using metal–organic framework templates for pH-responsive drug delivery
Lei Tang, Jiafu Shi, Xiaoli Wang, Shaohua Zhang, Hong Wu, Hongfan Sun, Zhongyi Jiang
From the School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People's Republic of China
Correspondence should be addressed to Hong Wu, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People's Republic of China, Email: firstname.lastname@example.com
A facile, efficient, and versatile approach is presented to synthesize pH-responsive nanocapsules (∼120 nm) by combining the advantages of metal–organic frameworks (MOFs) and metal–organic thin films. ZIF-8 nanoparticles are used as templates on which a thin film coating of iron (III)–catechol complexes is derived from the coordination between dopamine-modified alginate (AlgDA) and iron(III) ions. After the template removal, nanocapsules with a pH-responsive wall are obtained. Doxorubicin (Dox), a typical anticancer drug, is first immobilized in ZIF-8 frameworks through coprecipitation and then encapsulated in nanocapsules after the removal of ZIF-8. The structure of the iron(III)–catechol complex varies with pH value, thus conferring the Dox@Nanocapsules with tailored release behavior in vitro. Cytotoxicity tests illustrate the highly effective cytotoxicity of Dox@Nanocapsules towards cancer cells. This study provides a new method for preparing smart nanocapsules and offers more opportunities for the controlled delivery of drugs.
Despite significant advances in diagnosis and therapy over the past 30 years, cancer remains one of the leading causes of death. Patients treated by conventional strategies commonly suffer from frequent relapses and severe side effects. The lowered extracellular pH is important signatures strongly associated with cancer invasion, progression, and metastasis.[1,2] In this regard, pH-responsive delivery system represents an effective strategy for cancer therapies because most cancer tissues have lower extracellular pH values (pH=5.7–7.8) than normal tissues and the bloodstream, and pH values drop further inside cells, especially, inside endosomal (pH=5.5–6.0) and lysosomal (pH=4.5-5.0) compartments.[3] To date, different types of drug carriers, including liposomes, polymeric micelles, carbon nanotubes, mesoporous silica nanoparticles have been extensively studied for the construction of pH-responsive delivery system.
Nanocapsules are exceptionally promising materials with applications in areas as diverse as catalysis, imaging, drug delivery, and protection of sensitive agents such as enzymes and proteins. Especially in the drug delivery system, nanocapsules have gained tremendous attention due to their potential applications in encapsulation and controllable drug release. However, to be a promising drug delivery nanocarrier, nanocapsules should be biocompatible, readily synthesized, and able to control the release of a drug. However, despite considerable effort, developing nanocapsules that can meet all of these requirements is still a challenge. Our recent publication addresses this issue by combining the advantages of metal–organic frameworks and metal–organic thin films.
Metal–organic coordination chemistry has been widely explored due to its mild and controllable features, especially in the preparation of metal–organic frameworks (MOFs) and metal–organic thin films. [4,5,6] MOFs have emerged as one of the highest-potential drug delivery carriers due to their outstanding porosity features and facile synthesis procedures. Compared to conventional templates, MOFs can efficiently carry anticancer drugs and be completely removed under mild conditions, thus providing an advantageous and novel class of template material for nanocapsule preparation. Meanwhile, metal–organic thin films can also be formed based on metal–organic coordination chemistry through appropriate screening of organic ligands and metal ions. Metal–organic thin films exhibit potential applications due to their diverse properties, including hybrid physicochemical properties, stimuli responsiveness, and controlled functionality. It can be reasonably supposed that combining the advantages of porous MOF nanocrystal (as a sacrificial template/carrier for immobilization) and metal–organic thin film (as a pH-responsive wall for smart release) may offer a novel, feasible, and efficient approach to preparing stimuli-responsive nanocapsules for controlled anticancer drug delivery (Figure 1).
Recent studies indicated the new coordination polymer nanocapsules displayed obvious pH-responsive release performances (Figure 2a). At pH 7.4, a slow release of Dox was found, with less than 23% of Dox being released over 37 h. Incubation of Dox@Nanocapsules at pH 6.0 resulted in a slightly increased release of Dox to 25% within 37 h. When the incubation pH value was reduced to 5.0, a remarkable increase in Dox release was achieved with a high release percentage of 71% in 37 h. At alkaline pH condition (pH 8.2), the release behavior was notably depressed (only 14% after 37 h). To investigate the cytotoxic effects of the Dox@Nanocapsules, an MTT assay was used to examine the cell viabilities of HeLa cell lines. For the cell viability assays, free Dox, Fe–AlgDA nanocapsules without Dox, and Dox@ Nanocapsules were introduced into the culture media, respectively. As shown in figure 2b, the Fe –AlgDA nanocapsules without Dox had little cytotoxic effect on cells, whereas the Dox@Nanocapsules exhibited an effective cytotoxicity towards cancer cells. The free Dox showed higher cytotoxicity compared to Dox@Nanocapsules, which indicated that the nanocapsules provided an added advantage of controlled release.
Fluorescence microscopy images were used to study the intracellular release behavior of Dox@Nanocapsules. Red fluorescence imaging was performed to trace the released Dox. In the case of free Dox, the red fluorescence spread all over the cells in 2 h, primarily because the free Dox could easily diffuse into the cytosol. For the Dox@Nanocapsules (Figure 3), Dox was concentrated in the cytoplasm after 2 h's incubation, and there was only very slight red fluorescence in the nuclei. The whole spreading of red fluorescence was observed after 8 h. This delayed spreading demonstrated that the release of Dox from nanocapsules was in a slow, controllable and sustainable way in the cytosol.
To further elucidate the mechanism of pH-responsive release of Dox from nanocapsules, the suspension of nanocapsules was monitored as the pH value changed. The color of the suspension changed progressively from colorless, blue/ green, pink, to red when the pH was gradually increased from 4.0 to 9.8(Figure 4a). UV–vis absorbance spectroscopy also confirmed that the coordination state between Fe and AlgDA was affected by pH values (Figure 4b). Raman spectroscopy was recorded to further demonstrate the interaction of Fe3+-catechol complexes in the polymer networks after metal-organic thin film coating (Figure 4c and 4d). The peak at 1230-1550 cm-1 was ascribed to the vibrations of the carbon bonds in the catechol ring. The three major characteristic peaks of metal-catechol interaction appeared in the range of 470-670 cm-1 and their intensity increased with the increase of pH value. The peaks at 592 and 640 cm-1 were assigned to the interaction between the C3 and C4 oxygens of the catechol, respectively. The peak at 538 cm-1, which origniated from the change of the bidentate chelate, became weaker when the pH value decreased from 8.2 to 7.4 and to 5.0.
In summary, a novel approach is developed for the synthesis of pH-responsive nanocapsules via metal-organic coordination chemistry, where metal-organic frameworks (MOFs) serve as the sacrificial core and metal-organic thin films serve as the pH-responsive wall. The nanocapsules can effectively carry anticancer drugs by ZIF-8-mediated drug loading and exhibit pH-responsive fashion for controlled drug delivery.
Figure 1. Illustration of the preparation procedure of Dox@Na- nocapsules and the pH-responsive release behavior of Dox.
Figure 2. (a) In vitro Dox release profiles of the Dox@Nanocapsules at different pH values. (b) Cell viability of HeLa cells incubated with free Dox, nanocapsules, and Dox@Nanocapsules for 24 h.
Figure 3. Fluorescence microscopy image analysis of HeLa cells incubated with Dox@Nanocapsules for 2 and 8 h.
Figure 4. (a) Set of photographs of nanocapsules in different pH environments. (b) UV absorbance spectra of solution of nanocapsules at different pH values (4.0, 5.0, 6.0, 7.4, and 8.2). (c) Metal–organic coordination films 3 forming on the surface of plate glass at pH 5.0, 7.4, and 8.2 (prepared for resonance Raman spectroscopy). (d) Resonance Raman spectroscopy of Fe –catechol complexation at different pH.
- M. Pickup, S. Novitskiy, H. L. Moses, Nat. Rev. Cancer2013, 13, 788.
- J. M. Bailey, B. J. Swanson, T. Hamada, J. P. Eggers, P. K. Singh, T. Caffery, M. M. Ouellette, M. A. Hollingsworth, Clin. Canver Res. 2008, 14, 5995.
- L. Xing, H. Zheng, Y. Cao, S. Che, Adv. Mater. 2012, 24, 6433.
- P. Horcajada, T. Chalati, C. Serre, B. Gillet, C. Sebrie, T. Baati, J. F. Eubank, D. Heurtaux, P. Clayette, C. Kreuz, Nat. Mater. 2010, 9, 172.
- A. Bétard, R. A. Fischer, Chem. Rev. 2012, 112, 1055.
- J. Ran, L. Xiao, W. Wu, Y. Liu, W. Qiu, J. Wu, Nanotechnology 2017, 28, 055604.


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May 2002 Archives
Good Friday
Good Friday, Pt. 2
A Little Blip
Early Evening Blessings
Final Thoughts
Extended Play by The Connection (Review)
These are solid songs, songs that could definitely benefit from a little more depth in the studio, if only to polish the edges.
We Are The Boggs We Are by The Boggs (Review)
One of the best things going in the alt-country scene today.
Cry For Me by Breather (Review)
Breather has a rich atmospheric sound that's anchored down and energized by its darker currents.
Salt by John R. Williamson (Review)
Expect great things from Williamson in the future, and the future is now.
Faith and Devotions of a Satellite Heart by The Violet Burning (Review)
But where most worship albums leave me cold, this one doesn't, and the reason for that is simply Pritzl's writing.
Tienken EP by Au Revoir Borealis (Review)
Indeed, you really can lose yourself in this.
El Dorado LP by The Lassie Foundation (Review)
It's not rocket science, it's not going to change the world, but as music-as-pleasant-diversions go, El Dorado is a damn good one.
Lost Weekend EP by The Clientele (Review)
This release finds the band delving more into the atmosphere that, until now, has always been that hazy film giving their music it's surreal touch.
My Biz-nass
We Shall Be Free
Clone This
On It's Way
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My Latest ReviewsAll Reviews
I've also written for Christ and Pop Culture, ScreenAnarchy, Filmwell, and Christian Research Journal. I pay the bills by creating beautiful user interfaces and websites for Firespring and Red Bicycle.


text:
All managers will encounter disciplinary and grievance issues in the day-to-day running of their organisation.
Grievances can vary from staff requests to work flexibly around childcare needs to complaints about treatment and workplace behaviours.
Disciplinary procedures need to reflect the gravity of the issue and to be underwritten by sound management practice.
We are experienced in undertaking complex disciplinary and grievance investigations. As external investigators, we can investigate issues objectively and quickly.
We will:
- Work with you to determine the correct approach to the investigation and ensure that a robust and objective report is produced.
- Look objectively at underlying issues and distinguish between personal and structural issues.
- Ensure that personality or legacy issues don't slow the process down or cloud insights.
- Draw on wide-ranging interviewing techniques and experience in developing creative solutions.


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Oakland shuts down 'sweepstakes cafe' as alleged gambling parlor
Oakland city officials said Wednesday that they filed a lawsuit against an illegal gambling establishment in the city's Fruitvale District, a "sweepstakes cafe" said to be similar to other outfits across the country that have drawn law enforcement attention.
Lucky Strike Electronics, located at the corner of East 27th Street and Fruitvale Avenue, was in essence a "small casino," according to Oakland City Attorney Barbara Parker, who filed suit against the business last month in Alameda County Superior Court.
"Customers supposedly pay to use computers for business, communication or other purposes, but in reality the computers are used as slot machines or to play other games of chance," Parker's office said in a statement. "The business functions like a casino, with customers paying the house up front to gamble, and then receiving their 'winnings' from a cashier when they are done."
Oakland police raided the business after the suit was filed, seizing computers and other gambling-related equipment, Parker said.
"Small businesses are driving the resurgence of Oakland's economy," Parker said. "However, gambling businesses like Lucky Strike Electronics only deprive working families of resources and harm the quality of life in our neighborhoods."
The lawsuit seeks a court order preventing further nuisance activity at the location. The complaint also seeks civil penalties of $25,000 each from the property owner and the operator of the business.
Henry K. Lee is a San Francisco Chronicle staff writer. E-mail: firstname.lastname@example.com Twitter: @henryklee


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RhB Cement Silo Car, Uce 8028
The Rhätische Bahn possesses a multiplicity of cement silo cars, which can be found everywhere on this well-known narrow-gauge network. However, these standard "Mohrenkopf" wagons differ in detail and color, and this model offers a new variation for authentic RhB layouts. With it, the signals are set to "go" for cement traffic on your LGB layout.


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Salsa Brava is one of Northern Europe's most experienced and accomplished companies for teaching salsa, performing dance shows, and organizing events for companies or private gatherings. They are the winners of the Danish Salsa championship in 2004 and the Copenhagen Salsa championship in 2002.
They are looking forward to introduce you to our universe of sensual, energetic and elegant salsa.
After teaching salsa for more than 20 years, Salsa Brava is one of Denmark's most experienced dancing schools for Salsa and other Latin dances such as Bachata, Merengue and Cha-cha-cha.
They have developed a method which makes our students dance elegantly and with self-confidence after just a short period of time. Two important elements of our way to teach are to emphasize dancing technique, and the understanding of the rhythm and the music. They also focus on developing your personal style, starting right away.
It doesn't matter if you are a beginner or an advanced dancer. Dancers of all ages are welcome to join our classes, and if you have never danced salsa before, don't worry….with them you will be dancing confidently very soon!
All salsa styles
They teach all salsa styles – "New York", "LA-style" (cross body) and "Cuban". After finishing all our class levels, you'll be able to make combinations in a sensual way, dips, and advanced footwork.
You will have developed your personal style, and you will have wide knowledge about the dance technique you need to be a good salsa dancer. Last but not least, you'll be able to improvise to all kind of salsa music.
Salsa Brava is Fernando Hernández
Ima Mustafic
Ima started training gymnastics as a child. At 12 years old it was replaced with jazz, ballet, competitive ballroom- Latin dancing and Salsa.
Since 2003 she has been training with some of the best salsa dancers around the world while living in Barcelona, Madrid and New York.
After many years of training in ballet, jazz, Latin ballroom and salsa, Ima has trained, performed and competed in several dance styles around the world, which gives her a very broad knowledge of dance, performance and dance technique that she can pass on to her students.
SALSA L.A. & Cuban Style + BACHATA classes
Next season starts 06/25-17 with real latin teacher
Salsabrava dance-studio: Helgesvej 29, 2000 Frederiksberg.
(Frederiksberg swimming-pool, right side uptairs, 2 floor).
Frederiksberg Metro station. Bus 2 A (Aksel Moellers Have bus stop)
Saludos, Fernando Salsabrava Hernàndez
E-mail: email@example.com – Tel.: 2249 5834


text:
It is not an R package, but rather a collection of Fortran functions
that R uses from netlib:
On Wed, 9 Jul 2008, Jos Kaefer wrote:
> Hi
> When I type:
> > ?nls
> I come across this section:
> algorithm: character string specifying the algorithm to use. The
> default algorithm is a Gauss-Newton algorithm. Other
> possible values are '"plinear"' for the Golub-Pereyra
> algorithm for partially linear least-squares models and
> '"port"' for the 'nl2sol' algorithm from the Port package.
> The simple question is: where's the Port package?
> I can't find it on cran.
> Thanks,
> Jos
> ______________________________________________
> R-help_at_r-project.org mailing list
> https://stat.ethz.ch/mailman/listinfo/r-help
> PLEASE do read the posting guide http://www.R-project.org/posting-guide.html
> and provide commented, minimal, self-contained, reproducible code.
Archive maintained by Robert King, hosted by
the discipline of
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University of Newcastle,
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