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The last month has been exhausting and stressful. I got a new apartment to move in, a little cheaper than what I should pay to stay here. The new place is few blocks away from here so that's good. I think I'll be moving in 10 days. I didn't pack anything yet...
I am always tired and sleepy. Legs and arms tired and some sore. Why? I don't know. Probably because I am usually sleeping only 4 hours maybe 5 but hardly ever more than that. Sitting all day long at the computer is not helping at all.
On my work things sucks as usual. My coworker is still annoying with all his noises, comming to the office 30 minutes early to do nothing but curse and complain. The less he does the more money he earn, really I don't understand how the brain of my boss works if it even works. She is about to fire the other girl who works here. I lost all the interest in this job so I am doing only and exclusively the tasks they pay me to do. The last days I had to work dealing with a lot of bees inside my office, without water in the toilette every morning, bad internet connection, grumpy people and of course, the one who smells like dirty ass.
I sold another website and I am earning some money with designs works so I'll be able to move to the other apartment without incurring debts.
About family, I had a little more of drama because the problem with my sister where my mother tried to get involved but I told her to leave me alone. Martu is as usual being so fucking lazy with school and that add more stress on me.
This last month I don't feel like journaling, not writing on my bullet journal (only once at week), I dont feel like drawing, exercising, nothing at all.... I feel so MEH...
Michael and I started to play again Lineage since they opened a classic server. Even that was stressing me because we joined a group of people who are a waste. Skipping work to play all day long, spending a lot of money to buy things on game, drinking 24 hours, and obsessed with be top level... wtf is wrong with people???? While we were playing at night, they joined our party to get lvl and went afk. While Mike and I working at day, they lvling their characters without take us because we should stay there afk. Fuck that, I wont "work" in a game to afk people get level. I left the group then Michael followed me. Now we play a little almost every day before sleep without rush to get lvl and working in our own stuff. It's relaxing and there is noone pushing me to play. Two days ago Michael's brother joined us. It was nice to see them both sharing something. It was the first time I interacted with him.
I am trying to leave this Meh status, to get energy, to eathealthy and do workout again... I hope this don't take so long.


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VIDEO: Trying Vegan Junk Food With My 10-Year-Old Nephew
My 10-year-old nephew Kenzie is a notorious lover of childhood classic dishes, including chicken nuggets and ice cream. I decided to carry out a taste test with him, trying some classic vegan junk food including Quorn Nuggets and Swedish Glace Vanilla Ice Cream. Enjoy!

subset: commoncrawl


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The man who one-time had the richest contract in NFL history is now prepared to write perhaps the most important check of his life.
Hall of Fame quarterback Joe Namath appeared at a press conference on Sunday morning, held by the parents of Perry Cohen and Austin Stephano, the Florida teenage boys who have been missing since Friday when they went out on their boat and never returned. Namath is a neighbor of the boys and is not only offering his visibility to raise awareness that they are missing but he is opening up his bank account to do so.
The former New York Jets quarterback said he will pay $100,000 for the safe return of Cohen and Stephano. The boat that the two boys used has been found as the search and rescue continues but there have been no gains made in finding the two missing 14-year old boys.


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The beauty of being psychic means that you get to help many people out. But a world of responsibility could lie on the shoulders of the psychic readings rochester ny consultant. The consultant is a professional service provider, just like in any other industry, including that of the health and social services industries. But could it be possible to brand religion as an industry on its own?
Cynics would have you believe that this is so. But then again, many of them probably do not go to church. Or mosque or visit the temple on a regular basis, and so on and so forth. Perhaps the reader might care to wonder just how many psychics out there are faith-based in the sense that they regularly and openly practice in religions of their choice. And when you think about it, this is entirely possible.
Fundamental Christians may have a different word for psychics. Miracle workers. Or prophets even? There are those, and plenty. As the expression goes; you had better believe it. Speaking of which, this is perhaps central and crucial to the psychic's success rate. Bear in mind that not all of her readings will yield the desired and/or forecasted results. You could look at this another way as well. Another old saying then.
Actions speak louder than words. Take a crazy little example then. If the psychic forecasts that you stand to inherit millions with the emphasis on luck, this might entail you having to play the lotto not just once but at least a few times. Perhaps most importantly, and on a saner and more realistic and reasonable level, patrons of psychic readings should have faith and a belief that whatever the psychic reveals beforehand will come to pass.


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Health Insurance for Western Pennsylvania
Across every position, team, and department at UPMC Health Plan, we have one goal: to improve the health of our members by offering innovative products, cost-effective solutions, and service excellence. A career at UPMC Health Plan means working in a fast-paced, complex, inclusive environment. And the benefits aren't bad, either.
UPMC Health Plan is the second-largest health insurer in western Pennsylvania, owned by UPMC. We celebrate our roots in Pittsburgh, but think globally. We take the personal and professional development of our employees just as seriously as our members' health. And we pride ourselves on unique partnerships with our health system, community organizations, and the members, groups, and producers we serve. The UPMC Insurance Services Division also encompasses UPMC WorkPartners, LifeSolutions, UPMC for You and Community Care Behavioral Health.
To learn more about the opportunities available at UPMC Health Plan, click here.
Jimmy Liu
Dollar Bank
"I've been around the world, but Pittsburgh folks are phenomenal. Anyone you meet on the street will go out of their way to help you."
ImagineP!ttsburgh.com is a program of the
Allegheny Conference | AlleghenyConference.org


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Hey, it's me. And this is my blog. And this is your daily reminder to be selfish, because it's your life, happiness, and well-being at stake! 20 Things People Regret the Most Before They Die. Read this. Kick yourself in the ass. It's never to late to reinvent yourself. The Ultimate Cheat Sheet to Reinvention. Aside, you should follow the Altucher blog because it is raw, honest, and powerful; and worth your time reading every time Because I'm currently making art, i found these phrases worth noting. Not everyone will like my music, some will just hate it. I hope this is the worst I encounter. (sure would be boring though, polite yes) credit to this tumblr This is … Read More
The Life Review
What a week of mounting muck in the world: more scandals & more deadly storms. I doubt the NSA relates to this quote: "The more you know, the less you need." – Yvon Chouinard I'm just little ole me, minding my business. And by that, I came across a really applicable blog. The Top 5 Productivity Mistakes. These aren't cheesy, salesmen-esque points; they hone in precisely on psychological reasons behind our behavior. He's also a funny writer. In case you don't give a F**k about anybodies business but your own, and really are working to cultivate that, Forbes put out an article on the Ten Golden Rules for Living the Good Life. Get on it. Really essential, like worrying only … Read More


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There are many reasons why people love the windy city besides it's colorful attractions and amazing pizza. According to Learning English, Chicago ranks at the second most popular city to visit in America because of all of the great things it has to offer. Chicago is also home to a lot of famous people like Tina Fey, Chance The Rapper, and Gina Rodriguez. If you ever have the chance to be a tourist in Chicago, then here is a guide of top touristy things to do in Chicago.
Willis Tower – This tower is the second largest building in the United States. It was built in 1973 and now is home to many businesses and tours. A popular tourist attraction to do at Willis Tower is to master the SkyDeck, which allows you to stand on glass that is 1,353 feet above the city.
Millennium Park – This park is home to "The Bean," a glorious fountain, and The Lurie Garden which is full of flowers. Millennium Park is a big park that tourists love to enjoy. Take a trip to "The Bean" and take a signature picture in front of the mirrored sculpture.
Eat Chicago styled pizza – Chicago is known for having the best pizza around, serving many different styles of pizza. If you like deep dish pizza, Lou Malnati's is the best place to try a slice. If you prefer thin crust pizza, the place to try a slice is Pizano's Pizza.
Shedd Aquarium – This aquarium is 75 year old and is loved by a lot of people other than just Chicago locals. At this aquarium, guests get to see different types of species in eight large exhibits. This aquarium offers more than just tanks as well, they offer hands on experiences and 4-D experiences.
Navy Pier – Located on Grand Avenue is Navy Pier. This pier offers daily events including live music and boat tours. There are also fair rides, shops, and food places for guests to enjoy. Navy Pier basically has everything anyone could want out of a pier.
Beaches – What is a surprise to some, yes, Chicago has beaches. The most popular Chicago beaches are Oak Street Beach and North Avenue Beach. Visitors can lay out, rent a bike, kayak, or a jet ski, and enjoy concessions under the sun.
Magnificent Mile – Located on Michigan Ave. is the Magnificent Mile. This hot tourist attraction offers lots of shops for visitors and locals to shop until they drop. Magnificent Mile has stores such as Zara, Brooks Brother, and Chanel. Magnificent Mile is more than just shops, it has galleries that guests have previously enjoyed.
Museums – Another hot tourist thing to do in Chicago is to visit at least one museum. Chicago has a ton of museums throughout the city. A few popular ones include The Field Museum, which has natural history and the largest T-Rex known to man, the Museum of Science and Industry, which focuses on science and the innovation of science, and the Art Institute of Chicago, which has changing exhibits and beautiful art collections.
About the Author: Natalie is a guest contributor from America by Rail, a company that offers boat tours that depart from different locations including Florida.


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AIA Certified Continuing Education Units | Porcelain tile containing recycled content provides residential and commercial building projects with a durable, easy to maintain finish material for interior or exterior, floors, walls, or other surfaces. This course highlights the eco-friendly production practices of porcelain tile and details its contributions to the design and performance of a building.
Bookings are no longer available for this event.
Marco Ballarin
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San Francisco
Marco Ballarin is a regional sales manager that has a deep knowledge of the A&D community particularly inclined toward commercial project specifications.
Mr. Ballarin has worked in the ceramic tile business since 2006, he has been working as a regional manager promoting porcelain tile both on independent distribution and Architectural firms. Among his accomplishment he has been able to land important project for our company like the Tampa International Airport, The Hyatt Regency in Dallas TX and several important restaurant chains.
The objective of his presence at the show is to provide CEU (Continuing Education Units) to architects and designers. For your reference, CEU are credits that every architect needs to get to be able to maintain their operating license.


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1000 A celestial love. Pope Sylvester II gives Stephan of Hungary a crown containing 320 pearls, gems, and icons. Stephan was later made a saint.
1140 A childhood love. Eleanor of Aquitaine gives her friend Richard Animal a sapphire and gold ring with his initials. The two had studied together.
1236 A well-tressed love. Eleanor of Provence has nine jeweled chaplets and garlands for her hair when she marries Henry II. She later buys eleven more.
1299 Bridal rights. By Venetian law, only the bride may wear pearls at a wedding.
1375 A shining example. Alice Perrers, the mistress of Edward III, attends the Smithfield Joust as "Lady of the Sun," resplendent with numerous jewels. Her jewelry inventory lists 22,000 pearls alone.
1396 A lavish love. Queen Isabella of France is wed to Richard II of England with a ring of sapphire and ruby worth £100. He also gives her crowns, a gemstone collar, a gold belt, jeweled buttons, and a pearl and gold chaplet for her hair.
1414 A nice outfit. The Duke of Burgundy pays for a dress with sleeves embroidered in 960 pearls with the lyrics and notes to "Madame, I am Joyful".
1439 A mother's love. Albert von Hapsburg's pregnant widow steals the crown of St. Stephan of Hungary for her unborn son. She sells it back in 1463.
1477 A modern tradition. Mary of Burgundy weds the Archduke Maximilian of Austria. Historical records note, "At the betrothal, Your Grace must have a ring set with a diamond and also a gold ring."
1525 A Protestant love. Martin Luther marries Catherine von Bora to ".please himself, tease the Pope, and spite the Devil." The ruby and diamond ring is engraved with the words "Those whom God hath joined, let no man put asunder."
1534 Love clasp. Henry VIII to Anne Boleyn: ".seeing I cannot be present in person with you, I send you the nearest thing to that possible, that is, my picture set in bracelets.wishing myself in their place when it shall please you."
1588 A parting gift. From his deathbed, the Earl of Leicester sends Elizabeth I a rope of 600 pearls with a jewel in emeralds and diamonds as "a token of a humble faythfull harte as the last that ever I can send her."
1599 A lust restrained. A new law in Venice permits women to wear pearls only after 15 years of marriage.
1603 "A blue jewel from a fair lady." As Elizabeth I lays dying, a star-shaped sapphire and diamond ring is dropped from a window and brought north to summon King James of Scotland to claim the English throne.
1649 A devoted love. Charles I is beheaded wearing his favorite drop pearl earring. He bequeaths it to his daughter Mary.
1725 Riverbed bonanza. Diamonds are discovered in Brazil.
1751 White mystery. A new metal, platinum, is discovered.
1774 A brief alliance. Calling him "her husband," Catherine the Great bestows a palace and a 51-ct. oval diamond on her lover, Count Grigori Potemkin. The "union" lasts two years.
1776 An admirable attempt. Count Grigori Orlov gives Catherine the Great the 189.60-ct. "Orlov" diamond to regain his claim as lover and favorite. His attempt fails.
1786 Platinum and cream. The royal goldsmith Janety fashions a platinum coffeepot and sugar bowl for Louis XVI.
1797 An indiscreet love. Goya paints the Duchess of Alba wearing two rings, one marked "Alba" and the other "Goya."
1804 An old love. Josephine, the first wife of Napoleon I, gives him a watch and fob with words and symbols of love: Tender-a heart; Loyal-a dog; Passionate-a flame; Truthful-a mirror; Secret-a lock; Constant-a tower. The final links spell "united forever."
1810 A new love. Three bracelets spell out a message with the first letter of their gemstones. They list the name, birthdate, meeting, and marriage of Napoleon I and Queen Marie Louise, his second wife.
1821 An amorous love. Alexander I of Russia is besotted with the Marchioness of Londonderry and tempts her with an intense pink topaz, a yellow diamond, and a matched set of deep Siberian amethysts. She remained ".free of guilt."
1822 White Russia. Platinum deposits are discovered in Russia.
1829 White ice. Diamonds are found in the Ural Mountains in Russia.
1840 A true love. Queen Victoria marries Albert, Prince of Saxe-Coburg, with a ring symbolic of eternal love: a snake with its tail in its mouth.
1842 French caviar. Polynesia becomes a French colony, and black pearls are coveted throughout Europe.
1848 Midas touch. The California Gold Rush begins.
1853 A royal love. Emperor Napoleon III marries Eugenie de Montijo. Her wedding necklace is set with the Potemkin diamond, and her jewelry includes suites of rubies with white pearls and a fabled black pearl set.
1860 Silverglow. The Comstock Lode turns jewelry silver.
1866 Eureka! The Eureka diamond (10.73 cts.; also known as the O'Reilly Diamond) is found lying in the dirt in South Africa as part of a children's game.
1886 Seeing red. Mogok ruby mines in Burma are at their height.
1908 A discreet love. King Edward VII's "companion," Mrs. George Keppel, gives him a Fabergé cigarette case with a rose-cut diamond snake grasping its tail. Queen Alexandra returns it after Edward VII's death.
1910 A recurring love. Evalyn Walsh McLean visits Cartier in 1908 and gets the 94.80-ct. "Star of the East" diamond. Now, her dear husband treats her to the fabled Hope Diamond.
1917 A generous love. Morton Plant trades the keys to his mansion on Fifth Avenue to Cartier so his wife can have the pearls of her dreams.
1924 Mother lode. Platinum is discovered in South Africa.
1933 The golden rule. America abandons the gold standard. Now gold is for jewelry, not dollars.
1937 An infamous love. He could not rule ".without the woman I love." The union of Edward, Duke of Windsor, to Wallis Warfield Simpson is "cinched" by the sapphire and diamond marriage contract bracelet, created by Van Cleef & Arpels.
1947 A loving subject. Queen Elizabeth II receives a 23.60-ct. pink diamond for her wedding from Dr. John Williamson, the Canadian geologist who discovered diamonds in Tanzania.
1956 A fairytale love. Grace Kelly weds Prince Rainier of Monaco in a gown buttoned with cultured pearls. Her pearl and diamond wedding jewelry is all by Van Cleef & Arpels.
1957 An affluent love. Stavros Niarchos presents his wife, the former Charlotte Ford, with the "Ice Queen," a 128.25-ct. pear-shape diamond. The Ford family nicknames it "The Skating Rink."
1967 An imperial love. The Shah of Iran makes his wife empress with a crown and necklace of enormous emeralds, pearls, diamonds, and rubies, mounted by Van Cleef & Arpels.
1968 A billionaire's love. Aristotle Onassis weds Jacqueline Bouvier Kennedy with a 40.42-ct. marquise diamond engagement ring accompanied by more than a million dollars in ruby and diamond jewelry.
1969 A good year for cleavage. Liz Taylor becomes the new owner of "La Peregrina," the pear-shaped pearl given by Philip II of Spain to Mary I of England, and the 69.42-ct. pear-shaped "Taylor-Burton" diamond.
1979 Tickled pink. Colored and white diamonds are discovered at the Argyle mine in Australia. The '80s are awash in colored diamonds.
1980 White-hot metal. Platinum hits $1,047 per troy ounce.
1981 A historic love. Prince Charles proposes to Lady Diana Spencer with an oval sapphire bordered by diamonds. The "Lady Di" ring is widely copied.
1987 From Wallis to Liz. Liz Taylor buys the diamond "Prince of Wales" feather brooch ($623,000) at the Duchess of Windsor's jewelry auction.
1991 A material love. Madonna comes to the Oscars àla Marilyn Monroe in a 100-ct. diamond necklace, four bracelets, and pink diamond ring. Thank you, Harry Winston.
1993 A borrowed love. Donald Trump marries Marla Maples; the bride wears a $2 million tiara, another loaner from Harry Winston.
1996 Passion for color. Christie's auctions a .95-ct. purplish-red diamond for a record-breaking $926,000 per carat.
1997 Titanic love. "Le Coeur de la Mer" may have gone down with the ship, but you can get a $3.2 million, 120-ct. copy or a Web site version in blue topaz.
1999 Logo love. Ben Affleck gives Gwyneth Paltrow the first pair of Harry Winston millennium logo earrings.
2000 Lucky lady. Asprey & Garrard, New York, unveils the world's most expensive pearl necklace. Listed for sale at $3.2 million, it's made of 26 cultured South Seas pearls that took 10 years to collect.
Lael Hagan is a jewelry historian. A portion of this timeline was developed for the Jewelry Information Center.


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More than 100 pairs of pajamas and nearly 200 books were collected as part of the Pajama Project.
Students in Anne Solie's fourth-grage class ran the drive in which many Elm Lawn families participated, she said.
The program kicked if off with an all-school Pajama Day and read in. The Pajama Project ran from Monday, Nov. 7 to Friday, Nov. 18. In all, 103 pairs of pajamas and 195 books were collected.
All of the items will stay local and be donated to Middleton Outreach Ministroy, while some of the books will be donated to the Middleton Police Department, Solie said.
"The students were very excited to take part in helping out others,'' she said. "They were proud to be a part of helping others.''
Her students made posters, read announcements and counted and organized the donations.
"This program is so great because first of all contributions will stay in the community, second of all we came together as an Elm Lawn School community to help others, and finally we were able to provide some comfort and happiness to those in need,'' Solie said. "Our slogan was 'Comfy pajamas plus a good book equals happiness.'''


text: Home » Caging and Supplies » Humid Hides Humid Hides Feb 10, 2012 by Editor in Chief TortoiseForum.org - Lots of tips for creating humid hides for tortoises. @ TortoiseForum.org Advertise Here Related Posts Jan 24, 2012Humid Hides GeckoForums.net - Members show photos and advice about humid hides. Sep 14, 2012Sushi Box Humid Hide ReptileForums.net - This member has an innovative method for making a quick and easy humid moss hiding place for geckos. Lots of detailed how-to pictures and instructions. Jul 19, 2012Tortoise Hides TortoiseForum.org - A member wonders what sorts of things others use as hides for their tortoises. Jul 5, 2012Homemade Hides GeckoForums.net - Photos of lots neat hides that a member has made. Aug 15, 2012Cardboard Hides Arachnoboards - A member gets lots of advice when they wonder whether or not they can use cardboard to make hides for their tarantulas.


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23 September 2018
Century's Mitchell survives scare to seal GT4 crown as Hutchison/Mckay claim maiden win at #DoningtonDecider
22 September 2018
Championship challengers Minshaw/Keen and Tuck/Green claim #DoningtonDecider poles
The crews lying second in this year's British GT3 and GT4 standings will both start tomorrow's #DoningtonDecider from their respective class pole positions after the Barwell Motorsport Lamborghini shared by Jon Minshaw and Phil Keen plus Ben Tuck and Ben Green's Century Motorsport BMW prevailed in a damp qualifying session earlier this afternoon.
18 September 2018
British GT adds second Donington date to 2019 calendar
The British GT Championship will make two visits to Donington Park next season following confirmation of its 2019 calendar.
17 September 2018
GT3 #DoningtonDecider preview: Optimum duo on the cusp of history
Once more unto the breach, dear friends, once more. After 375 laps lasting 13 hours spread across eight races and six rounds the 26th annual British GT Championship boils down to 120 more minutes at Donington Park this weekend (September 22/23) when the GT3 and GT4 Drivers' and Teams' title winners will be crowned.
17 September 2018
GT4 #DoningtonDecider preview: five into one just won't go!
That five crews travel to Donington with a chance of winning the title says everything you need to know about the continuing rise of GT4. Indeed, never before have so many pairings – five – featured in the class' season showdown.
5 August 2018
Optimum's unstoppable Aston Martin claims victory at Brands while Balfe McLaren wins GT4
Flick Haigh and Jonny Adam claimed the British GT Championship points lead with victory in the penultimate round at Brands Hatch earlier today following a thrilling battle against Sam De Haan and Jonny Cocker's Barwell Motorsport Lamborghini.
31 July 2018
British GT titles on the line at Brands Hatch
Brands Hatch plays host to the penultimate round of the 2018 British GT Championship this weekend, and there's an outside chance that both Drivers' titles could be decided over the course of Sunday's two-hour race around the daunting GP circuit.
30 July 2018
British GT unveils seven-round 2019 calendar
British GT will feature a largely unchanged calendar in 2019 following confirmation of the provisional schedule during SRO Motorsports Group's annual Total 24 Hours of Spa press conference where a new GT2 class was also unveiled.


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Bhubaneswar: Police on Friday arrested three persons for allegedly attacking Odisha Labour Minister Susanta Singh's brother and three of his associates in Bargarh district.
The arrested persons are from Sohela area, the constituency represented by Susant Singh.
Police said some unidentified miscreants attacked Labour Minister's brother Subrat Singh and three others at Banabira village under Sohela block of Bargarh district late Thursday night.
Police suspect that the attack on Labour Minister's brother might be related to by-poll for Bijepur assembly constituency scheduled on February 24.
The injured were initially taken to community health centre at Sohela and later shifted to VSS Institute of Medical Sciences and Research, Sambalpur.


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A Different Kind of Christmas SweaterDecember 23, 2014
21 Comments
love the layering!
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Great look, I love the layering
Cool layering technique
This is so cute Alex! Love all of the grey tones in the background and of course the twinkling lights too 🙂 Wishing you a Merry Christmas!
Cute Wrap Jacket, lovely style!
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Trending:Vitamin C Vegan Weight Management
Living with this distressing digestive complaint can be difficult. Find out what causes IBS, common symptoms and how to manage it Written by Cheryl Freedman on March 7, 2019 Reviewed by Dr Rob Hicks on March 14, 2019 Ever experience stomach pain and bloating? If so, you may be wondering if your symptoms are actually irritable bowel syndrome (IBS). IBS is a common gut condition, affecting up to one in...
It leaves one in five people in the UK on the lookout for the nearest toilet, but what exactly is IBS? We took a closer look at this increasingly common condition and how it affects the digestive system. What is IBS and who does it...


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Purchase this article with an account.
Heather L Chandler, Rachel B Matusow, Elizabeth Curto, Kristen J Gervais; Cyclosporine A Induces Autophagic Cell Death in Lens Epithelial Cells to Prevent Posterior Capsule Opacification Ex Vivo. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3046. doi: https://doi.org/.
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To determine the appropriate Cyclosporine A (CsA) dose and minimum drug delivery time needed to prevent posterior capsule opacification (PCO) in an ex vivo model and evaluate the mechanism of CsA-induced cell death.
Lens capsules were harvested from canine cadaver eyes using an established ex vivo model of PCO. Lens capsules were treated with 0, 5, or 10 µg/mL CsA for 0, 2, 3, 4, 5, 6, or 7 days, and then maintained in culture for a total of 28 days in the absence of drug. CsA-treated lens epithelial cells (LEC) underwent routine transmission electron microscopy (TEM), western blotting, and fluorescent staining to evaluate the mechanism of cell death.
Lens capsules treated with 5, 6, or 7 days of 10 µg/mL CsA showed a significant decrease in ex vivo PCO formation; 7 days of drug delivery was sufficient to prevent PCO. Morphologically, CsA-treated LEC were swollen, had intact nuclei, lacked peripheral chromatin condensation, and demonstrated prominent vacuolization; TEM revealed autophagosomes. LC3-II protein expression and acridine orange fluorescence increased in CsA-treated cells. Dose dependent changes were observed in all experiments.
Seven days of intracapsular CsA drug delivery prevented ex vivo PCO formation. Morphologic changes and TEM suggest that CsA is able to induce LEC death via autophagy; this is a novel finding in the lens. Acridine orange is a marker for acidic vesicles and LC3-II is a protein involved in mediating autophagic death. Expression of these markers in CsA-treated LEC further supports this new mechanism of drug-induced LEC death.
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Ian Ogg analyses the last 10 renewals of the King Edward VII Stakes at Royal Ascot and picks out the key statistics.
Victory for Sir Michael Stoute would take his tally of King Edward VII Stakes winners to eight, one behind race record holder John Porter.
Two of the Newmarket handler's winners have come in the last four years and Crystal Ocean has leading claims after his taking third to the re-opposing Permian in the Dante Stakes on just his third career start.
This has not been a happy hunting ground for Aidan O'Brien (his one winner came in 2004) whose Sir John Lavery skipped the Derby after struggling at Lingfield; he should be able to step up significantly on that form and prove his running to be all wrong.
Call To Mind's profile is not dissimilar to 2015 winner Balios and Father Time stepped up from being beaten in the Fairway Stakes to win this prize in 2009. William Haggas' colt still looked inexperienced at Newmarket and is another who could take a large stride forwards.
John Gosden has won two of the last six renewals and also saddled runners to be third, second and third in three of the other four years which automatically accords his runners respect but they all appear to have something to find with Crystal Ocean who is taken to justify favouritism.
* Winners have been priced between 11/4 and 12/1 with one favourite successful.
* Winners have had between two and seven career starts.
* Nine of the winners had had either two or three starts during the current season.
* Seven winners had won a race during the current season.
* Eight winners finished in the first three on their preceding start.
* One of the exceptions finished tenth in the Derby, the other was a 1 3/4l fourth in a handicap.
* No winner made their first racecourse appearance prior to August of their juvenile season.
* Winners have been rated between 92 and 109.


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About Us
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We believe that a remarkable change is taking place in the field of wellness testing. Specifically, that the body's fluids, namely saliva, can be used as a cost-effective, pain-free, alternative to traditional methods of sample collection and will soon become the blood of the 21st century™.
Our mission is to promote wellness and better health. We do this by offering a wide range of state-of-the-art, analytical testing services with a focus on quality, precision, competitive pricing and, most importantly, service.
Welcome to wellness. Welcome to FLUIDS iQ®.
*FiQ Lab Services Corp., accredited by the Standards Council of Canada for the scope of accreditation found at www.scc.ca
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Archive for June 2018
6 Tips To Prevent Car Theft
Cars are one of the most sought after and valuable material possession to people. Both a luxury and necessity, it makes going to places easy and comfortable. Anything of such importance is significant and can be devastating if it has been stolen.
Car theft is on the rise each year. Law enforcements and communities are scrambling to stop its progress. They are urging car owners to take precautions to protect themselves. Auto thieves have successfully executed their crimes time and time again, because they can easily overcome car alarms and other security equipment.
With that in mind, you're now feeling exposed and desperate for protection. There are easy, simple and practical ways on which you can accomplish this. Most car theft cases would have been avoided if their owners were aware of these safety tips. Read More
5 Important Things You Need To Know Before Expanding Your Business
With all the hard work and time you have put into your business, it is finally flourishing and increasing in profit. To balance and optimize the growth of your business, you might want to consider developing and expanding to prolong and maintain your business' success.
But before you take those steps, there are some things that you might want to know about before you gamble your company's future.
Facts You Might Not Know About Household Cleaning Products
A lot of us are guilty of spending too much time and hard labor keeping our houses spotless and organized. Knowing that you have scrubbed and disinfected every space, nook and cranny, is utterly satisfying. The whole purpose of these endless routines is to keep the family comfortable, safe and healthy.
What you might not be aware of is, you might be overdoing it. Have you asked yourself, "Am I doing more harm than good?" Did you know that your cleaning products might contain harmful chemicals? Here are facts you might want to know about your household cleaning products. Read More
Dangers You Need to Know About Home Electrical Problems
Homeowners are always on the lookout for dangers hidden outside and inside their homes. Protecting the safety and health of their family is their number one priority. Our homes should be a safe haven and not a threat. The most commonly overlooked danger, is failure to prevent home electrical problems from worsening. It can cause minor and major accidents, such as, property damage, electrocution and house fire.
Accidents may be unexpected but they can be prevented. There are signs that may warn you about electrical problems in your home. It is highly helpful for you to be able to know what, where and how to look for possible problems with your electrical system.


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Last week saw The Government, energy suppliers, consumer groups and Ofgem meet to agree a way forward on saving homeowners from crippling energy bills, as the Summer's energy price rises start coming into force.
Whilst the headlines were all about the profits the big six energy providers were making since the increases, many would have been hoping for some form of of compulsory capping and reduction of the present charges.
What actually happened was the parties emerged with a new mantra – Check, Switch & Insulate to save.
In a nutshell, we're being encouraged to shop round the different suppliers for a cheaper deal, check on our present energy tariff's to make sure we're on the best tariff possible and insulate our homes to make them more energy efficient.
Suppliers will be writing to 8 million quarterly credit customers to tell them how they can save just by switching their payment method.
An agreement was also reached on encouraging take up of the cheapest tariff options – some energy providers were singled out recently as not offering their cheapest deal to mystery shoppers.
And from this December, some 4 million homes will be contacted, informing the occupants they're eligible for free or discounted insulation products like Loft or Cavity Wall insulation.
Although renewables like solar panels already have incentives in place, it was disappointing not to see them mentioned in the summit review as one viable way of reducing energy bills – something homeowners could undertake to organise themselves with the outcome, in most instances being a substantial return on the investment plus cheaper energy bills from the start.
If you've already switched, checked and insulated, then installing renewable energy generation on your property may be your only viable option (aside from sitting in the dark, without the heating on).
Solar installation companies are still offering some very good deals on your own paid for installation including shared ownership and finance options. And despite what you may have read about over-subscription, free installation companies are still looking to meet their quota's of suitable, south facing properties in many areas.
This article first appeared in our weekly homeowner newsletter dated 24th October 2011. Click here to read the full newsletter.


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Know Crucial Reasons of Contracting a Personal Injury Attorney
Accident is never an anticipated event; it normally occur when it is least expected to anyone at any time. In the event of such incident, the first thing which you should think of is how to engage a proficient personal injury attorney in handling your case; this is the right expert who is very well versed with the due legal process involved in the pursuit of personal injury cases. Regardless of the part which you could have played in the occurrence of the accident, whether it is your mistake which led to the occurrence of the accident or the negligence of the other party, it is always advisable to hire a proficient personal injury attorney so as to be on the safe side. Here are the benefits which you reap by engaging a skilled personal injury attorney on the onset of your personal injury case.
The personal injury cases are on no win no pay basis; you only pay the attorney from the settlement. This is a unique case which has zero upfront legal fees. They also don't charge for legal consultation.
It is only a personal injury attorney who is skilled to know your claim worth. As a layman it is very hard for you to know how much your claim is worth. The attorney guides you on which is the most offer to accept from your insurance company. Insurance adjusters are out to please their employers and they will do anything to give you the least settle possible. The insurer cannot just agree to compensate you rightly because such companies are out to make profit. They may claim to use the available tools but getting the right estimate of the final value requires an expert who knows and understands the subtleties of your particular injury case. It is worth knowing that cases are very unique and using standard tools is not the best way forward. To be on the safe side, use personal injury attorney services who is adept at leveraging these tools to get the best settlement possible.
The attorney is also conversant with the whole legal process. Some of these include the complicated filing of medical documents. It is such a bad feeling to know that you missed thousands of dollars from your insurance settlement just because you did not follow the due legal process; insurance will always work smart to achieve this.
The lawyer will also work hard to ensure that he has improved your odds. If you opt to work your case with your insurer is the same as fighting without weapons; they will definitely beat you with their vast skills. Whether the case is an open and shut one, the insurance company is more knowledgeable and have a better bargaining power to outwit you.
A Simple Plan For Researching Experts


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Summer To-Do List
Now that Ace is getting more active and able to really enjoy more I wanted to put together a fun Summer to-do list. I love the idea of making Summer all about fun, relaxation and enjoying the simple things. Here is what we have come up with so far.
Summer To-Do List
2. Go to the Beach.
4. Play in the sprinklers.
6. Swim lessons.
7. Visit the Young at Art Museum.
8. Visit the Museum of Discovery and Science.
9. See a fun play/ show.
10. Watch fireworks.
12. Have a picnic.
13. Make play dough.
14. Car washing fun (once Ace can walk).
15. Make a fort in the living room on a rainy day.
16. Go to the Library.
17. Take Ace to his first movie.
20. Breakfast for dinner.
21. Bake cookies.
22. Go to a Marlin's game.
23. Go to Story time.
24. Feed the ducks.
25. Eat lots of Watermelon.
26. Go mini-golfing.
27.Go to Lion Country Safari
28. Go to Sea Aquarium
29. Go Bowling
30. Go to the Keys House31. Go to Jaxson's for Ice Cream 32. Bar-B-Q with friendsAnd don't forget to enter my first GIVEAWAY! You can enter daily by tweeting about it and pinning the giveaway. Check it out HERE!
27.Go to Lion Country Safari
28. Go to Sea Aquarium
29. Go Bowling
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novineon cro
Pre-clinical research
Laboratory testing of prototypes
We analyze the complex relationship between user requirements and technical requirements for our clients. Using structured methods we specify and evaluate alternatives from the perspective of future customers.
Medical evaluation of prototypes and technical development of new products
Parallel to our regular testing of medical products, we further develop product prototypes. The medical parameters that are thus compiled, e.g. forces or other physical application parameters, serve as the basis for further product development. We place great value on the development of short feedback cycles and the avoidance of inefficient iteration steps.
Planning and execution of pre-clinical studies
We offer our clients the planning and execution of standardized experimental studies including usability tests, with proven methods in our labs.
We adhere to strict quality standards in the execution and documentation of projects. As a contract research organization (CRO) we have been certified to carry out contract research in the field of medical technologies according to ISO 9001. We are regularly audited by the DEKRA Certification GmbH.
Please contact us if you have questions or require further information regarding our research services.


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Rahuls visit to Bhatta Parasaul mere drama: BSP
Lucknow: Dismissing Rahul Gandhi's visit to Bhatta Parsaul on Tuesday as facical, Uttar Pradesh's ruling BSP said if he is sensitive to the problems of farmers he should pressurise the Centre to formulate a pro-farmer land acquisition policy.
"The party strongly condemns dramatics being done by the Congress leader in the name of kisan mahapanchayat in Bhatta Parsaul," a BSP spokesman said here.
He said that in reality Mr. Rahul should visit Congress-ruled and supported states, since farmers there faced "real problems".
"If he is actually sensitive to the problems of farmers, he should force his government at the Centre to formulate a pro-farmer land acquisition policy like the one announced by UP government," the spokesman said.
The BSP spokesman said if the Congress-led UPA government does not table a bill for a uniform national policy on land acquisition in the monsoon session of parliament, the party would stall the House.
"BSP will extend full cooperation if Congress and Mr. Rahul take an initiative to formulate a national policy during monsoon session," he said.
The BSP spokesman alleged that when Congress "failed" to understand the problem of farmers during 38 years of its rule in UP but says it would understand the same by the time of coming state assembly elections.
"This proves that Congress' love for farmers is a part of its poll strategy," he added.
The spokesman alleged Congress was solely responsible for the poor state of the people, especially farmers, in the state.


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IK Multimedia and Fender Musical Instruments Corporation have announced that AmpliTube Fender is now shipping.
AmpliTube Fender is the official Fender amp and FX software suite, with a selection of 45 Fender guitar and bass amps, cabinets, stompboxes and rack effects (including the '65 Twin Reverb, '59 Bassman LTD, '57 Deluxe, '64 Vibroverb Custom, '65 Deluxe Reverb, Vibratone, Super-Sonic, Metalhead, Fender Blender, Phaser, Fuzz-Wah and others).
- Stand-alone and plug-in software for VST/AU/RTAS platforms
- 12 guitar amps with 12 original matching cabinets and more
- 6 stomp effects and 6 rack effects
- Tone flexibility: mix and match amps, cabinets, mics and more
- 5 modules: digital tuner, stomp pedal board, amp head, cabinet plus mic, and rack effects
- 2 configurable rigs with up to 32 simultaneous effects
- Comes with SpeedTrainer, IK's media player and riff learning module, and Riffworks T4 recording software
- Can be expanded with any "Powered by AmpliTube" models using X-GEAR
- Can be controlled live with StompIO, StealthPedal or any other MIDI controller
- Hundreds of presets included, with more online in the AmpliTube Preset XChange area
Pricing and Availability:
AmpliTube Fender is already available through selected IK Multimedia dealers around the world and in the IK online store, in 2 versions:
- AmpliTube Fender®: the official Fender® guitar and bass, amp and FX software with 45 gear selections consisting of 12 amps, 12 cabinets, 6 stompboxes, 9 mics and 6 rack FX. Also includes Riffworks T4 for guitar recording and AmpliTube X-GEAR for expandability with any "Powered by AmpliTube" software and live control usage. MSRP €169.99 (excluding taxes).
- AmpliTube Fender Studio: to plug your guitar into your computer Includes StealthPlug USB audio cable interface and AmpliTube Fender SE (15 pieces of select gear with 4 amps, 5 cabinets, 2 stompboxes, 2 mics, 2 rack FX), plus Riffworks™ T4 for guitar recording and AmpliTube X-GEAR for expandability with any "Powered by AmpliTube" software. MSRP €109.99 (excluding taxes).
Check out www.ikmultimedia.com/fender/features for more info.


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Filter events and get the results you need
We want to help farmers and agribusiness owners improve their business management skills to improve management productivity, increase profitability, and fulfill their long-term goals.
It is accomplished through workshops, seminars, and individual on-farm consultations involving farm business management, strategic and tactical planning, record keeping, financial analysis, and computer applications for farm managers, educators, lenders, and others.
Breakout sessions on Poultry, Pigs, Vegetables, Fruits.
Resources to help boost farm profitability & income for farms, manage your finances, learn about record keeping, marketing, and how to reduce risk.
Connect you with available funding opportunities well.
. Sessions will be as practical as possible.
Seminars and Workshops on :
FEE: 200GHC (Early Bird: Before 1st December- GHC150)
Register here: https://agriprohub.com/agribusiness
Discover great experiences with eGotickets


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The children moved up into Year One a little earlier than usual this year. They had two fabulous transition days in their new classroom before their summer holidays. This was a wonderful opportunity for them to meet their teachers, explore their new indoor and outdoor classrooms and familiarise themselves with the rules and routines of Year One.
The children had great fun exploring their new outdoor area, playing with the water play outdoors, mixing wet sand and chalking on the floor. Indoors they had the chance to play in the different areas of the classroom, use the large floor number square game and get messy in the Creative Area. As a focus task we looked at art work inspired by Georgia O'Keeffe and Paul Klee as we will be thinking about these artists in September during Arts Weeks. The children either painted or used pastel colours to add colour and shade to shape pictures which will form part of a new display in school.
A fabulous two days was had by all and we are looking forward to the children coming back in September.


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Following years of pleading from Madison Avenue, Nielsen Media Research Monday quietly told its clients that in 2005 it would provide data that would ... Read the whole story
Today, there are two battles going on in the media business that we can regard as object lessons. One is taking place in television ... Read the whole story
Future Network USA, the publisher of a growing cache of enthusiast titles such as PlayStation 2 Magazine, Official Xbox Magazine, and Guitar World, is ... Read the whole story
In 2009, after what will then be a 17-year run as host of the Tonight Show, current host Jay Leno will turn the slot ... Read the whole story
Sync magazine's December issue will include a special CD-ROM disk featuring both bonus editorial and advertising content. Read the whole story


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There is heterogeneity in the literature regarding the anatomy, exact location, and definition of the intersesamoid ligament (IL). Anatomic knowledge of the IL and its variations are important for surgeons who undertake corrective surgery for hallux abducto valgus (HAV). The IL was dissected in 16 feet from 32 formalin-fixed cadavers (12 females, four males; mean age at death, 76.6 years) to examine its morphology. The length, width, and thickness of its constituent bands were recorded with a digital caliper. Descriptive and correlational statistics were used to investigate the relationships between band size, age at death, and sex. A literature review was conducted to compare our data to those of previous studies. Results suggest that the size of the sesamoids may change as a result of HAV deforming forces, which may cause lengthening of the IL. The IL stabilizes the sesamoid apparatus of the first metatarsophalangeal joint (MPJ) and should be evaluated in HAV correction. Anatomic knowledge of the complex morphology and relations between the IL and sesamoids is critically important for surgeons correcting HAV deformities.
The intersesamoid ligament (IL) of the first metatarsophalangeal joint (MPJ) is an essential structure that bridges both tibial and fibular sesamoids of the hallucal sesamoid complex [1-4]. Hallux abducto valgus (HAV) encompasses sesamoidal deviation, malalignment, and metatarsal rotation, all of which act at the capsuloligamentous structure of the 1st MPJ [2-3, 5-7]. The IL is also a major stabilizer of the base of the proximal phalanx and counters shear forces from about 60% of a person's body weight [5-6]. These functions suggest that the IL plays a major role in preventing HAV.
HAV is a complex deformity that includes lateral deviation of the hallux, medial deviation of the first metatarsal head, and lateral deviation of both sesamoids [6]. HAV prevalence is estimated at 23% of adults aged 18 to 65 years and in 35% of adults over age 65. HAV increases with age and is more prevalent in females [8]. Detailed anatomic awareness of the exacerbated effect of IL on sesamoidal deviation is important to consider in surgical correction of HAV.
There is a current lack in normative cadaveric data that solely pinpoints the dimensions of the IL. Instead, the literature has grouped the majority of the ligamentous structures of the first MPJ as a whole. These data have identified the anatomy of the MPJ, but have yet to describe findings using morphometric and statistical analyses [1-3, 6-7]. There is also an absence of studies correlating the difference in IL length and the prevalence of HAV.
The IL has been anatomically described as a ligamentous structure that connects both medial and lateral sesamoid bones of the first metatarsophalangeal joint [9]. Additionally, the flexor hallucis longus tendon is juxtaposed to the plantar surface of the intersesamoid ligament [3]. Confusion is apparent in the literature when differentiating between the plantar plate and IL. Some papers refer to the IL as the central portion of the plantar plate [4]. However, the more commonly accepted description is that the IL is more dorsal to the plantar plate [1-3]. It is necessary to conduct studies to distinguish the IL from the other structures in the hallucal sesamoid complex.
HAV causes medial translation of the metatarsal head, which leads to the proposal that although the IL stabilizes the sesamoids, a constant overbearing force may lengthen the IL [6]. The purpose of this cadaveric study was to examine and statistically analyze the morphology of the IL. This study was driven by the paucity of anatomic data on the pathologic changes that affect the IL and sesamoids in patients with HAV. This understanding will foster future research to specifically focus on how clinical implications of HAV can cause a significant length differentiation of the IL. Ultimately, this relationship can create a new tool for correcting HAV in patients.
Materials & Methods
Thirty-two formalin-fixed feet from 16 cadavers (12 females, four males) were dissected (16 right and left) from both dorsal and plantar aspects to expose the IL. All of the specimens were extracted using blunt and sharp dissecting tools in an effective manner to expose the intersesamoidal ligament. Proper technique involves many steps including dissection from the plantar aspect through the skin, fat, and fascia at the level of the first MPJ. The tendon of flexor hallucis was maintained and moved to the side to expose the plantar plate. Careful dissection through the plantar plate allowed the ligament to be visualized from outside the first MPJ. Following the measurement of all external structures, we then opened the joint capsule to visualize and measure the ligament from within the first MPJ. Length, width, and thickness of IL and sesamoids were measured with a digital caliper (Hawk, Inc., Cleveland, Ohio). Total length and width of each foot were measured. Measurements were compared in non-hallux valgus (HAV) feet and HAV feet. HAV feet were verified by observation. The data was analyzed using Statistical Package for the Social Sciences (SPSS Version 20.0, IBM, Armonk, NY). Descriptive and correlational statistics were used. A P-value of less than 0.05 was considered significant. Histology was performed on certain specimens to verify ligamentous structures. Digital radiographs of the cadaveric HAV feet were taken using a model 715 A-BD x-ray unit (X-CEL X-ray, Inc., Crystal Lake, IL).
From the plantar aspect (outside capsule), the IL mean (SD) length was 8.66 (1.21) mm, and the mean width (SD) was 6.27 (1.48) mm (Figure 1). From the dorsal aspect (in capsule), the IL mean (SD) length was 6.47 (0.85) mm, and the mean (SD) width was 2.24 (0.61) mm. Mean (SD) thickness from dorsal to plantar (DP) was 3.03 (0.65) mm. Five of 32 (15.6%) feet had HAV. Independent-samples t-tests between non-HAV and HAV feet revealed the following significant differences for left feet: medial sesamoid length (plantar) (P=.002) and lateral sesamoid length (dorsal) (P=. 020). For right feet: medial sesamoid length (dorsal) (P=.003), and plantar (P=.014), with lateral sesamoid length (dorsal) (P=.004). For both feet (total): medial sesamoid length (dorsal) (P=.008) and plantar (P=.035). There is a moderately strong direct relationship between IL length and lateral sesamoid width when measured from a dorsal aspect. There is a strong direct relationship between IL length (measured from a plantar aspect) and medial sesamoid width (measured from both plantar and dorsal aspects). The data suggests that the total length of the medial and lateral sesamoids increase in HAV feet.
The severity of HAV has been described as either mild, moderate, or severe, based on weight-bearing radiologic assessments [10]. Determination of HAV severity is reliant on two angles: the hallux valgus angle (HVA) and the intermetatarsal angle (IMA). For the HVA, normal is considered <15°, mild is <20°, moderate is 20°- 40°, and severe is >40°. For the IMA, normal is considered <9°, mild is ≤11°, moderate is <16°, and severe is ≥16° [10].
The IL is the main connection between the medial and lateral sesamoid bones. It must be cut to remove either the medial or lateral sesamoid following trauma and is often severed during severe HAV surgery to correct a bunion deformity of the first MPJ. We found that the mean length of the IL was 8.66 mm, and the mean width was 6.27 mm. From the dorsal aspect (in capsule), the mean length of the IL was 6.47 mm and the mean width was 2.24 mm. The mean thickness from dorsal to plantar was 3.03 mm. Due to the connection between the sesamoids via the IL, in HAV surgery, reapproximation of the sesamoid complex underneath the head of the first metatarsal is important for biomechanical stability. If conservative efforts are unsuccessful, surgery is the recommended next option. The most common procedure is the chevron osteotomy due to its effectiveness and consistent results [11].
Currently, surgical correction usually involves transection of the IL to allow removal of the lateral sesamoid in severe deformities. The length and width of the IL is the key factor in determining the distance between the sesamoid bones, and our results suggest that the size of the sesamoids may change as a result of HAV, causing lengthening of the IL. Further studies are needed to better understand the role of the IL and sesamoids in HAV deformity utilizing a larger sample size. Anatomic knowledge of the complex morphology and relations between the IL and sesamoids is critical for surgeons correcting HAV deformities due to the deviation of the sesamoid complex, and the resultant pathologic changes.
- David R, Delagoutte J, Renard M: Anatomical study of the sesamoid bones of the first metatarsal. J Am Podiatr Med Assoc. 1989, 79:536–44. 10.7547/87507315-79-11-536
- Munuera P, Dominguez G, Polo J, et al.: Medial deviation of the first metatarsal in incipient hallux valgus deformity. Foot Ankle Int. 2006, 27:1030–1035. 10.1177/107110070602701206
- Alvarez R, Haddard R, Gould N, et al.: The simple bunion: anatomy at the metatarsophalangeal joint of the great toe. Foot Ankle. 1984, 4:229–240. 10.1177/107110078400400502
- Sanders T, Rathur S: Imaging of painful conditions of the hallucal sesamoid complex and plantar capsular structures of the first metatarsophalangeal joint. Radiol Clin North Am. 2008, 46:1079–1092. 10.1016/j.rcl.2008.09.001
- Beaman D, Nigo L: Hallucal sesamoid injury. Oper Tech Sport Med. 1999, 7:7–13. 10.1016/S1060-1872(99)80034-3
- Tanaka Y, Takakura Y, Sugimoto K, et al.: Precise anatomic configuration changes in the first ray of the hallux valgus foot. Foot Ankle Int. 2000, 21:651–65. 10.1177/107110070002100804
- Aseyo D, Nathan H: Hallux sesamoid bones. Anatomical observations with special reference to osteoarthritis and hallux valgus. Int Orthop. 1984, 8:67–73. 10.1007/BF00267743
- Yammine K: The sesamoids of the feet in humans: a systematic review and meta-analysis. Anat Sci Int. 2015, 90:144–160. 10.1007/s12565-014-0239-9
- Standring S.: Gray's anatomy: the anatomical basis of clinical practice. Elsevier Health Sciences, London; 2015.
- Hecht P, Lin T: Hallux valgus. Med Clin North Am. 2014, 98:227–232. 10.1016/j.mcna.2013.10.007
- Scharer B, Devries J: Comparison of chevron and distal oblique osteotomy for bunion correction. J Foot Ankle Surg. 2016, 55:738–742. 10.1053/j.jfas.2016.01.036
Relationship Between the Intersesamoid Ligament and Sesamoid Bones in Cadaveric Feet with Hallux Valgus
Ethics Statement and Conflict of Interest Disclosures
Human subjects: Consent was obtained by all participants in this study. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
The authors thank Ms. Linda Chusuei for helping with the figures. Most importantly, the authors graciously thank the persons who donated their bodies for the advancement of medical education and research.
Article Information
Cite this article as:
Fiacco R C, Ream G M, Wilson C, et al. (November 03, 2017) Relationship Between the Intersesamoid Ligament and Sesamoid Bones in Cadaveric Feet with Hallux Valgus. Cureus 9(11): e1819. doi:10.7759/cureus.1819
Publication history
Received by Cureus: October 25, 2017
Peer review began: October 30, 2017
Peer review concluded: October 30, 2017
Published: November 03, 2017
© Copyright 2017
Fiacco et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Relationship Between the Intersesamoid Ligament and Sesamoid Bones in Cadaveric Feet with Hallux Valgus
Figures etc.
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Book publication dates, CD and DVD release dates, radio and television broadcasts, and other events I'm involved in.
Hear me talk about The Visitors Deluxe Edition and what's up with ABBA.
An interview with me about The Visitors Deluxe Edition and ABBA in general will be broadcast on the George Ellis show on BFBS Radio Northern Ireland on Saturday, May 19 at circa 10.45 am BST.Click here to listen live to the interview.


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HARTFORD, Conn. — State Transportation Commissioner James Redeker has cautioned legislators against replacing Metro-North Railroad as the operator of the New Haven line linking Connecticut to New York City.
Republican Sen. Toni Boucher of Wilton and Republican Sen. Tony Hwang of Fairfield have introduced legislation that would force the state Department of Transportation to put the contract out for competitive bids. Boucher said Connecticut or Metro-North may seek changes this year.
The Hartford Courant reports that Redeker told the General Assembly's Transportation Committee Wednesday that replacing Metro-North isn't practical. He said no company in the country has the staffing and technical skills to run the New Haven line and three branch lines.
Several legislators from southwestern Connecticut say their constituents are unhappy with slow, unreliable rail service and want a different contractor.


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Who: Group M, Cabinet Office, Carat
Where: UK
When: November 2014
Law stated as at: 10 December 2014
What happened:
WPP's media division Group M issued High Court legal proceedings leading to suspension of the award of the Cabinet Office media account to its rival Carat following a tender process. In last month's judgment, the Technology and Construction Court ruled that the suspension should be lifted. A new contract will now be signed with Carat.
Group M had taken advantage of rights under the Public Contracts Regulations 2006 and general EU Treaty principles of equal treatment, transparency and non-discrimination, which apply in public procurement cases such as this. Under the Regulations, the contracting authority (here the Cabinet Office) must refrain from entering into the new contract once it becomes aware that a dissatisfied tenderer has issued a claim form relating to the public procurement process in question. The Cabinet Office applied to lift the automatic suspension and the judge held that: (a) American Cyanamid injunction principles apply in cases such as this; (b) Group M's claims for breaches of the Regulations did not disclose a "serious issue to be tried"; and (c) the "balance of convenience" and "adequacy of damages" tests under American Cyanamid principles in any event pointed to lifting the statutory suspension. These principles are: Is there a serious issue to be tried? Are damaged an adequate remedy? What is the balance of inconvenience?
Group M had argued that the statutory duties in the Regulations and applicable EU Treaty principles had been breached on the basis that tenderers had not been treated "equally and in a non-discriminatory way", that the Cabinet Office had failed to act in a transparent way, that it had not conducted the procurement in a manner free from manifest error and had not complied with principles of good administration or evaluated all tenders fairly and objectively. In particular they alleged (amongst other things) that the assessment of the "sustainability" of the pricing that Carat had put forward (as required under the invitation to tender (ITT)) was flawed. Group M maintained that Carat could not conceivably have put forward sustainable prices that were lower than Group M's: given Group M's larger market share, they argued that Carat's proposed prices (which were lower than Group M's) would likely only have been sustainable if they were 8% higher than Group M's.
The judge was not convinced by the basis of Group M's claim, citing amongst other things the fact that no evidence had been put forward as to the profit margins the two tenderers had budgeted for. If WPP was aiming at all times for a 15% margin (as per press reports) but Carat was prepared to cut its margins in order to secure work, then that – said the judge – could provide a "potential explanation for Group M coming second on this occasion". Further, he considered there was a strong case for saying that the sustainability assessment as set out in the ITT should not have been expected to include an analysis of each tenderer's underlying costs – information that would not have been available to the Cabinet Office or its media auditors Ebiquity.
The judge therefore held that he was satisfied that in this case there was no serious issue to be tried. Accordingly, the automatic suspension was lifted.
Why this matters:
For those involved in public contracting, this is the latest case to address the question of which test the court will apply when deciding an application to lift an automatic suspention. There is a complex interplay between the Remedies Directive 2007/66/EC and the Public Contracts Regulations 2006 and this judgment (following another recent case of NATS (Services) Ltd v Gatwick Airport this autumn) makes it clear that the courts will apply American Cyanamid principles and are not inconsistent with the Remedies Directive.
For media agencies and public bodies subject to the Regulations, the case is a reminder of the legal measures available to unsuccessful tenderers wishing to challenge the outcome of a public procurement process. It also underlines the value of stating very clearly in invitations to tender exactly how key measures (such as "sustainability" here) will or will not be evaluated. Any arguable ambiguity around key evaluation criteria risks may potentially open the door to legal challenge.
A copy of the judgment can be found here.
For advice on UK public procurement issues please contact firstname.lastname@example.com.


text: I am so stressed that even posting this is causing an anxiety attack. I feel like I can't breathe, my heart is racing, my palms are sweaty...and I've taken 1mg klonopin. difficult child's anxiety is at an all time high. Everything - and I do mean everything - is now a trigger. She *completely* lost her mind over the idea of having an ultrasound today, so needless to say, she didn't have one done. She is still feeling bad, however I think it's all a direct result of her anxiety. She is catastrophizing and obsessing over any thought that crosses her mind. It is literally making her physically ill. She hasn't been to school since last Tuesday, although yesterday and today were snow days. We have doctor's notes for the days she's missed. But, I know she's not going to go tomorrow. And I don't know what to do. Eventually juvenile court will get involved because of truancy, but I really don't know what to do. She has all but shut down. The anxiety has total control over her. She doesn't want to do homebound or partial days. She doesn't want to go back to homeschooling, even if I were homeschooling vs the online school. We don't have any other options. And I'm sick. This fever that has been going on for like 3+ months now is over 100 and I'm having cold sweats. I'm not sleeping because I keep waking up drenched in sweat. Except yesterday, I slept all day. I'm exhausted, drained and feel like I'm out of options. But, I don't know what other options I have. I'm it. I'm her only safe person. I have an appointment with the new psychiatrist on the 17th, but the first appointment is just me. I don't know what to do until she can get in and...see what happens. There's other stuff, too, unrelated to difficult child that is just pushing everything over the edge with me. I keep having to stop her and tell her that I can't do this right now - an hour or so into the catastrophizing and obsessing and crying and and and. I feel like I can't breathe. Just thinking about it causes anxiety attacks. Hell, just reading the articles on how stress effects your health that I posted on the News Forum stressed me out. Seriously. It's out of control. I have an appointment with a psychologist tomorrow for my SSDI application for a "Mental Status Examination". Not really sure why as I didn't apply based on depression. Maybe it's related to the cognitive issues, I don't know. I do know that I'm ripe for it, though. I'm going to try to get in to see my doctor tomorrow. Something has to give. Why in the hell am I running fevers for months on end if I don't have an autoimmune disorder? If it's not autoimmune, what is it and what do we do? I can't keep living like this with no end in sight...no treatment in sight...no relief in sight. I can't breathe. I feel like I'm suffocating. I can't stand it. I can't stand it. I can't stand it. I can't stand it. And I'm angry. I'm angry at difficult child for refusing to help herself for so long and now it's come to this. But, what good is that going to do?


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Getting in shape this summer
Gerard Borne, Staff Reporter
June 12, 2019
With the loss of continuity in students' schedules over the summer, many can struggle with maintaining healthy habits. Dr. Ryan Green, assistant professor of athletic training, talked about the best way to stay in shape over the summer. "The first step everyone should do is to make a personal...
Mud Ballerz take victory at Swamp Bowl
Maiah Woodring, Staff Reporter
May 3, 2019
Students gathered in mass to participate in the annual spring festivities of the joint REC Fest and Swamp Bowl collaboration "Fais Do Do and Swamp Bowl" for its second occurrence. Scheduled from 3:00 p.m. - 7:30 p.m., in front of the Pennington Student Activity Center on Thursday, May 2, the team...
Creating an engaging environment for kids
Diamond Hollins, Staff Reporter
February 27, 2019
After-school programs offer a convenient, helpful and engaging setting for children. Recreational Sports and Wellness organizes the "REC Kids After School Program" for kids from 5-13 years old. It aims to craft an educational and fun-filled environment by offering homework help to children, activities...


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Smartphone Controlled Coffee Maker
$99 $129.99
extra capacity professional-style grounds basket, includes free phone app for easy operation, requires apple ios 7 or android 4.0 or higher, customize brew with pre soak and brew temperature, holds eight 5oz cups,9in diameter, 15.5in H,imported
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Hey all!
I love my JP15 to absolute pieces, I have not been able to put it down since I got it. I do have one super minor issue: black dot side markers on a roasted neck = I can't see anything! lol
Has anyone replaced these inlays or come up with a clever solution?
I'm considering just removing them myself and replacing them with Luminlay, but if anyone has a better suggestion, I'm all ears.


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- About Us
- Merchandise
- Pre-Plan
- Veterans
- Resources
Leola (Jackson) TaylorJune 6, 1931 ~ July 11, 2017 (age 86)
Leola Taylor died Tuesday July 11,2017 in Conroe.Service of Celebration Say. July 22,2017 at Greater Zion Missionary Baptist Church 13588 FM2854 Conroe.
Interment at Golden Gate Cemetery.
Preceded in death by her husband Arthur,she is survived by her Son Marvin
Daughter Margie Grandchildren Virgil Taylor,Veranda Taylor,Derringer Taylor Vernon Taylor, Brittany.Taylor and Keisha Haynes.
A host of Great Grand Children Neices Nephews and special friends.
Her extended family of The Greater Zion Missionary Baptist Church Family, Jessie Manning,Carrol Stoneham,Rev. Gerald Stoneham.
Casketbearers:Holiday Oneil,John Miles, Gerald Bell ,Edgar Straighter,Jr,Ronnie Fulton,Garry Bennett O. Sherman, Ryan Oneil.
Honorary Casketbearers: Virgil Taylor,Demon Taylor,Vernon Taylor Kellen Taylor.


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Joshua Gordon is an awesome dude. A dude who quit a job that wasn't a good fit to find his own way.
Step one: Quit.
Step two: Learn how to support a family of four on only $2000 a month. The family story can be found here.
Step three: Help cool people do amazing things AKA Marketing Awesomeness.
The story that unfolds in-between is very inspiring. From the "weekend of coolness and skulduggery" to the "thrashing around" period and finally the "hands in the air, forget this!" moment. Josh made it through and shares his story with us.
Part one: The story.
Part two(out next week): What can you learn from Josh's story and how to apply it.
Keep it B.E.A.T.


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Eltham Matters is run by two of Eltham's many Councillors – Charlie Davis and Spencer Drury. Its focus is on the issues that matter to Eltham residents, although occasionally this means writing about decisions by the Woolwich-based Greenwich Council, the Mayor of London or national government.
Cllr Charlie Davis
Charlie has recently been selected as the Conservative candidate for the Greater London Assembly in the Lewisham and Greenwich constituency for 2020.
Cllr Spencer Drury
Spencer has been one of the three Councillors for Eltham North Ward since 2002. He is currently one of two Conservative Councillors for Eltham North, being joined by Charlie Davis following a by-election in November 2016.
Born in Woolwich, Spencer is a married father of two teenage children who lives on the Eltham side of Shooters Hill.
Spencer was first elected to Council in 2002 and has served on Greenwich Council as a Councillor for Eltham North ward since that time. He has worked with a range of excellent fellow Councillors over that period including Dermot Poston, Douglas Ellison, Nigel Fletcher and Charlie Davis. Spencer was Deputy Leader of the Opposition from 2004 to 2006 and Leader of the Opposition from 2006 to 2015.
Spencer is an active ward Councillor who has led many campaign locally including for the warm water pool to be included in the Eltham Centre and to restore free parking on western Glenlea Road.
Spencer is a Trustee of Eltham United Charities (which provides free housing for older people in Eltham) and the Severndroog Castle Building Preservation Trust (which looks after Severndroog Castle).
Spencer works at Colfe's School in Lee where he is currently Director of Sixth Form.


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ID needed at tip
PEOPLE using the tip in Carsons Road, Mangotsfield, now have to prove they live in South Gloucestershire.
PEOPLE using the tip in Carsons Road, Mangotsfield, now have to prove they live in South Gloucestershire.
The council, which runs the Sort It! recycling centre and three others in Yate, Stoke Gifford and Thornbury, stepped up residency checks last month.
Users may now have to show documents that prove who they are and where they live. Official documents that can confirm both types of information - such as driver's licences, utility bills, council tax bills or passports – are acceptable.
South Gloucestershire Council says that every tonne of waste tipped by unauthorised users, such as non-residents or commercial traders, costs the council £100 per tonne to process. Unauthorised use can also create delays and inconvenience for residents.
* Residents can now use ordinary plastic bags to line their food recycling caddies, thanks to new mechanical sorting techniques that separate the bags from food waste.
Further information on South Gloucestershire's waste and recycling services is available from www.southglos.gov.uk/recycling


text: My boyfriend and I have been together over a year. We live together and I'm madly in love with him. He's fully committed to me, he loves me and he's even helping me raise my daughter. I REALLY REALLY REALLY want to be married. I know that it'll probably be smart to wait. I'm still in school, he's not sure of what he wants to do yet. We're both still young (Me, 21 Him, 25) but I just cant shake this feeling of wanting to get to the alter as soon as possible. Idk if it's because I saw my mom and sisters in happy marriages or because I just love him so much. But I just cant stop thinking about it. He says he eventually will marry me but he always tells me that i need to just relax and enjoy what we have now. Idk why it's so hard. I constantly look at rings and wedding dresses and it even upsets me a little if I hear that one of his friends is getting married or having a baby. Idk what else to do. I wish I didnt feel this way. I'm desperate. And i need advice.


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To The Editor: The Newspapers in Education project is admirable and many times I read the special page you publish to encourage children to read.
However, you do a real disservice to our children's education when you make blatant grammatical mistakes. For example, in today's paper (T-N, July 20) you published a photograph of a group of BMX riders practicing for the state qualifier races at Jackson Park.
The headline, "Peddling Toward Victory," leaves us with the impression that the people in the photograph are practicing to sell, PEDDLE, bicycles or bicycle gear, not PEDALING to quality for the BMX races.
According to the Fifth Edition of the Oxford English Dictionary, a peddler is "A person who goes about carrying small goods for sale, especially one who goes from door to door with goods in a pack.
"It is also a person who works in a petty, incompetent, or ineffective way or a retailer of gossip."
This last can definitely be applied to today's newspapers.
There is no doubt that the computer's spell-check is a wonderful program. However, you should make sure the words used are the correct ones.
Dinorah Kranker
The reader is right. The error was mentioned prominently in Today�s Edition, editor Bill Moss�s daily critique of the Times-News at BlueRidgeNow. com. The July 20 blog said: "Ouch! Unless they�re selling while on their bikes, the BMX riders are pedaling toward victory, not peddling . Watch your usage."