text:
|Allen Steckle
| File:Steckle, UMich.png
Steckle pictured in The Official National Collegiate Athletic Association football guide, 1899
|Biographical details
|July 1872
Freeport, Michigan
|Error: Need valid birth date (second date): year, month, day
|Playing career
|Coaching career (HC unless noted)
Oregon Agricultural
|Head coaching record
College Football Data Warehouse
|Accomplishments and honors
All-American, 1898
Allen Chubb "A. C." Steckle[1] (July 1872 – March 5, 1938) was an American football player and coach. He played tackle for the University of Michigan from 1897–1899 and later served as the head football coach at the University of Nevada and Oregon State University, then known as Oregon Agricultural College. Steckle was selected as an All-American in 1898 and achieved fame in 1903 when his Nevada Sagebrush team, drawn from a school with 80 students, defeated the University of California football team.
Early yearsEdit
Steckle was born in July 1872 at Freeport, Michigan. His father, Abraham B. Steckle, was born in Waterloo Township, Ontario, Canada, in 1842, and worked as a farmer. His mother, Sarah (Furtney) Steckle, was also a native of Waterloo Township. His parents were married in December 1867 in Waterloo County, Ontario. At the time of the 1880 United States Census, Steckle was residing with his parents and six siblings in Campbell Township, Michigan.[2]
University of MichiganEdit
Steckle played football for the University of Michigan from 1897 to 1899 and was captain of the 1899 team. In 1898, Steckle was among the first western players to be named to an All-American team after being selected by Walter Camp as his second-team tackle. He helped Michigan win its first Western Conference championship in 1898 and was selected as the best tackle in the West. One newspaper wrote that he was "as good a defensive player as one will find anywhere."[3]
Coaching careerEdit
From 1901 to 1903, Steckle served as the head football coach at the University of Nevada. In 1903, he was also appointed to the position as the university's Physical Director.[4] In his three seasons as the head coach, he compiled a 6–9–2 record. When Steckle's Nevada Sagebrush team defeated the University of California in 1903, it was the cause of a statewide celebration. The entire front page of the Daily Nevada State Journal was given to coverage of the game, and the banner headline read: "CALIFORNIA'S PROUD COLORS LOWERED BY THE DOUGHTY ELEVEN FROM SAGEBRUSHDOM."[5] Steckle's picture appeared on the front page, and the paper praised his efforts in turning Nevada into a football power:
"Out of the eighty students of the N.S.U. have been selected eleven young men who were moulded into shape by Dr. Steckle, the best football coach who ever came to the Coast. He made of them the peers of the flower of the California universities."[5]The victory of a university with only 80 students over the University of California with its 3,000 students was haled as a historic accomplishment, and "Coach Steckle's brand of 'roughhouse'" play was given much of the credit.[5]
Steckle's star players at Nevada from 1901 to 1903 were his younger brother Ivan X. Steckle, who played halfback, and Abe Steckle, who played tackle. Ivan Steckle was reportedly "the hero of all Nevada during the football season of 1903, when in a game with the University of California on the U.C. field, he grabbed the football close to the Nevada goal line and made a wonderful 86-yard run to the California goal line, scoring a touchdown for the Sagebrush players and bringing victory to the team."[6] Ivan left Nevada after the 1903 season to follow his older brother to the University of Michigan Medical School. Ivan died from typhoid fever in 1909, and Steckle accompanied his brother's body to the family's old home in Freeport, Michigan.[6]
In 1919, a Nevada newspaper rated Steckle as the best football coach Nevada ever had and described his accomplishments as follows:
"It was under the coaching of Dr. Steckle that Nevada was able to defeat the University of California and play a tie with Stanford as well as bang it over the crack athletic club teams that San Francisco boasted when the great college game was in its hey dey. He was rated at that time as one of the best coaches in the West."[7]Steckle was also remembered at Nevada for his ability to instill "college spirit" in the school's student body. In 1919, a Nevada newspaper noted that "there was more enthusiasm displayed in college athletics while he was coach than there has been in all the years since he left."[7] As a medical doctor and athletic coach, Steckle was also known for his belief in physical conditioning. He was known to require every athlete to be in perfect physical condition before playing in any intercollegiate or "big" game.[7]
Steckle was also a basketball coach. While at Nevada, he coached the women's basketball team to "a high stage of perfection, being able to take the measure of all the coast college teams."[7]
Oregon StateEdit
After his success with the 1903 Nevada team, Steckle was offered a higher salary to take over as the football coach at Oregon State.[8] He served as Oregon State's head coach from 1904 to 1905 and compiled a 10–5 record in those two seasons.[9]
Medical careerEdit
After graduating from the University of Michigan in 1899, Steckle enrolled in the Illinois College of Physicians and Surgeons.[4] Steckle's principal profession was as a medical doctor and surgeon.[7] However, he took time out of his medical practice to coach college football for several years.
After the 1905 football season, Steckle decided to quit coaching and focus on his medical practice.[8] At the time of the 1920 United States Census, he was living in Vancouver, Washington with his wife, Margaret (born c. 1887) and two daughters, Catherine J. Steckle and Sarah E. Steckle. His occupation was listed as a physician in general practice.[10]He maintained his medical practice for many years in Battle Ground, Washington. At the time of the 1930 United States Census, Steckle was living in South Battle Ground, Washington, with daughters Catherine J. and S. Elizabeth Steckle, and his sister-in-law, Nesbit Daline. His occupation was listed as a physician and surgeon.[11]
In March 1938, Steckle was found dead beside his automobile on a side road near his home with "a .38 caliber bullet through his head."[12][13] Steckle left his home the previous night for a house call and never returned. Several threatening letters were found among Steckle's papers, including one demanding "$2,000 or else."[12]
Head coaching recordEdit
|Nevada Sagebrush (Independent) (1901–1903)
|Oregon Agricultural Beavers (Independent) (1904–1905)
|Oregon Agricultural
|Oregon Agricultural
|Oregon Agricultural:
- ↑ Bentley Historical Library Necrology File.
- ↑ Census entry for Abraham Steckle and family. Ancestry.com and The Church of Jesus Christ of Latter-day Saints. 1880 United States Federal Census [database on-line]. Census Place: Campbell, Ionia, Michigan; Roll: 584; Family History Film: 1254584; Page: 302B; Enumeration District: 102; Image: 0326.
- ↑ "Western Football". Nebraska State Journal. 1899-01-22.
- ↑ 4.0 4.1 "Physical Director". Daily Nevada State Journal. 1903-02-22.
- ↑ 5.0 5.1 5.2 "CALIFORNIA'S PROUD COLORS LOWERED BY THE DOUGHTY ELEVEN FROM SAGEBRUSHDOM". Daily Nevada State Journal. 1903-11-08.
- ↑ 6.0 6.1 "News Comes of Death of Ivan Steckle". Reno Evening Gazette. 1908-09-09.
- ↑ 7.0 7.1 7.2 7.3 7.4 "Nevada May Get Noted Coach Again". Reno Evening Gazette. 1919-03-31.
- ↑ 8.0 8.1 "Nevada Coach of 1903 Tells of Victories: Dr. A.C. Steckle Here for Visit; Taught Boys Lots of Football". Reno Evening Gazette. 1931-09-03.
- ↑ "Oregon State Football Media Guide". http://www.osubeavers.com/pdf3/79999.pdf?ATCLID=153842&SPID=1952&DB_OEM_ID=4700&SPSID=27968. Retrieved 2008-01-07.[dead link]
- ↑ Census entry for Allen C. Steckle and family. Ancestry.com. 1920 United States Federal Census [database on-line]. Census Place: Vancouver, Clark, Washington; Roll: T625_1922; Page: 6A; Enumeration District: 32; Image: 288.
- ↑ Census entry for Allen C. Steckle and family. Ancestry.com. 1930 United States Federal Census [database on-line]. Census Place: Battle Ground South, Clark, Washington; Roll: 2485; Page: 2B; Enumeration District: 39; Image: 736.0.
- ↑ 12.0 12.1 "Former All American at Michigan Is Found Dead, Gun At Side". Fresno Bee The Republican. 1938-03-06.
- ↑ "Former Football Star Found Dead In Auto". Lima News. 1938-03-06.
External linksEdit


text:
Duc-Hau Le
One of the challenging issues in biomedicine is to identify candidate genes likely to be associated with specific diseases. To tackle this issue, many computational methods have been developed for ranking disease candidate genes according to their relevance to a disease of interest. This relevance has been defined as functional similarity or relatedness between candidate genes and known disease-associated genes. In addition, it is widely accepted that most functions of cell are controlled by biological networks constituted by interactions between genes, proteins, metabolites and other molecules. Defects by mutations on genes/proteins may cause a disease occurred in a person. Also, these mutations may affect other genes/proteins through structures of the biological networks. In this study, we propose a novel method, namely BoolDGP, to assess the relevance of candidate genes to a disease of interest by measuring the degree of mutational effect from known disease-associated genes to candidate genes. Particularly, we mutate known disease-associated genes and measure the effect of this mutation on candidate genes based on Boolean dynamics of biological networks. Based on this value, candidate genes can be prioritized and finally top-ranked candidate genes can be selected as novel promising disease genes. Simulation results on a set of diseases showed that the proposed method is superior to a state-of-the-art one, which is based on a random walk with restart algorithm. Using the proposed method, we identified 27 genes associated with breast cancer with evidences from literature.
Disease gene prioritization, the task of predicting the most plausible candidate disease genes, is an important issue in biomedical research, and a variety of approaches have been proposed (1, 2). Identification of disease-associated genes also leads to more effectively researches about therapies for genetic diseases (e.g., hypertension, breast cancer, etc…) and gradually approaches a future of personalized medicine. In past decades, linkage analysis was usually used to identify novel disease genes, in which susceptible loci including hundreds of genes are investigated, and thus it is much costly for doing many experiments in wet lab. Therefore, ranking/prioritization methods for such candidate genes are introduced (genes are ordered by their relevance to a disease of interest). Highly ranked genes are further investigated to find out associated biomedical evidences. Therefore, the goal of gene ranking/prioritization is to identify novel disease-associated genes.
The candidate gene prioritization methods have been proposed by three main directions: i) Functional annotation-based; ii) Network-based; and iii) Machine learning-based. In which, functional annotation-based methods have prioritized candidate genes by measuring the degree of similarity of each candidate genes to a set of known disease genes based on profiles which were built from many functional annotation data sources (3, 4, 5). Therefore, those methods mostly focused on the integration of various biological datasets in order to obtain more accurate similarity. However, those approaches are limited in that functional annotation data sources have not covered whole human genome yet. Beside the functional annotation-based methods, machine learning-based techniques based on binary classifiers for identification of disease-associated genes have been also studied. At the early, machine learning-based studies usually approached disease gene prediction as a binary classification problem. Indeed, a number of binary classification techniques have been proposed to the problem such as decision tree (6, 7) k-nearest neighbors (8), Naïve Baysian classifier (9, 10), artificial neural network (11, 12) and support vector machine (13, 14, 15). In these studies, the learning samples are comprised of positive training samples and negative training samples. In which, positive training samples are constructed from known disease genes, whereas negative training samples are the remaining which are not known to be associated with diseases. This is the limitation of binary classifier-based solutions for disease gene prediction problem, since the negative training set should be actual non-disease genes. However, construction of this set is nearly impossible in biomedical researches because it is often the case in biomedicine that not observing an association does not imply the association does not exist (there are no proven negatives). In fact, the unknown set may contain unknown disease genes; therefore, to reduce this uncertainty of the earlier methods, semi-supervised methods have been proposed to the problem (16, 17, 18), where the classifier is learned from both labeled (i.e., known disease genes) and unlabeled (i.e., the unknown genes) set. However, negative samples must be still defined in those studies. To overcome limitations of these two main approaches, network-based methods for identification of disease-associated genes have been proposed (19, 20). These network-based methods mainly based on biological networks and therefore they are not limited by the coverage of functional annotation data sources. In addition, they dominate the other two main approaches is because they are based on a principle of "disease module" (e.g., genes/proteins associated with the same or similar diseases usually form functional/physical modules on gene/protein interaction networks (21, 22, 23)). Furthermore, network-based methods target to the essence of disease gene prediction problem, which is ranking/prioritization, instead of classification of candidate genes (i.e., assign a candidate gene to either disease genes or non-disease gene class) as machine learning-based methods do.
It is widely accepted that defects by mutations on genes/proteins may cause a disease occurred in a person. Also, these mutations may affect other genes/proteins through structures of the biological networks. This phenomenon has an underlying reason that mutations on genes/proteins affect the robustness of biological networks and propagation of the effect is controlled by structural properties of biological networks. In this study, we propose a new method, namely BoolDGP, based on Boolean dynamics of biological network to measure the effects from known disease genes to candidate genes. Based on this value, candidate genes can be prioritized and finally top-ranked candidate genes can be selected as novel promising disease genes for further experimental studies. Comparing performance of the proposed method on a set of 25 disease phenotypes with that of a state-of-the-art network-based method, Random Walk with Restart (RWR) algorithm (24), we found that our method outperforms the RWR-based one. In addition, we used the proposed method to identify novel breast cancer-associated genes. Interestingly, 27 out of 50 highly ranked candidate genes are evidenced to be associated with breast cancer.
Materials and Methods
Biological networks and known disease gene associations datasets
To assess mutational effects of known disease-associated genes to candidate genes, we used a large-scale human signaling network collected from a published study (25). This network consists of 1,539 nodes and 4,754 interactions and is the largest one available on literature. In addition, a set of diseases and their known associated genes were collected from OMIM (26). Because only small set of genes are available on the current human signaling network and only diseases with at least two known associated genes are suitable for leave-one-out cross validation analysis; therefore, a set of 25 disease phenotypes was finally selected.
Boolean dynamics-based measure for prioritizing candidate genes
To define a measure assessing the mutational effects of known disease-associated genes on candidate genes, we employed a Boolean network model, which has been widely used to represent biological networks and successfully captured some biological characteristics (27, 28, 29, 30, 31, 32, 33). In particular, it has been also frequently used in simulating the dynamics of various signaling networks (34, 35, 36, 37, 38, 39, 40, 41, 42).
A random Boolean network
When a Boolean network is represented by a directed graph G (V, E), each vi∈V has a value of 1 ("on") or 0 ("off"), which represents the possible states of the corresponding elements. The value of each variable vi at time t+1 is determined by the values of ki other variables with a link to vi at time t by the Boolean function. Hence, we can write the update rule as where we randomly select either a logical conjunction or disjunction for all signed relationships in fi with a uniform probability distribution. For example, if a Boolean variable v has a positive relationship from v1, a negative relationship from v2, and a positive relationship from v3, then the conjunction and disjunction update rules are (t) and (t), respectively. In the case of a conjunction, the value of v at time t + 1 is 1 only if the values of v1, v2, and v3 at time t are 1, 0, and 1, respectively whereas, in the case of a disjunction, the value of v at time t + 1 is 1 if at least one of the states of the clauses, v1(t), , and v3(t) is 1. Although there can be many other logical functions in addition to conjunction and disjunction functions, biological networks were successfully described by Boolean models using only those two functions in many previous studies (31, 32, 33, 43, 44, 45, 46). In addition, the sign of each link is determined between positive and negative ones uniformly at random.
Given a Boolean network with N Boolean variables, v1, v2, …, vN, we define a network state as a vector consisting of values of the Boolean variables: there are 2N states in total. Each state transits to another state through a set of N Boolean update functions, f1, f2, …, fN. We can construct a state transition diagram that represents the transition of each state. A state trajectory starts from an initial state and eventually converges to either a fixed-point or a limit-cycle attractor. Attractors can represent diverse behaviors of biological networks, such as multi-stability, homeostasis, and oscillation (47, 48, 49). In addition, we define a transient sequence of values of a node v as follows: When a Boolean network G(V, A) was initialized with v1(0), v2(0), …, and vN(0) at the starting time 0, vi(t0,t1) represents a sequence of the transient values of a node vi during the time interval from t0 to t1.
Effectiveness from a node to another node in arandom Boolean network
In Boolean networks, we propose a novel measure, effectiveness, to quantify the influence from a node to anothernode in terms of the network dynamics. To define it, we first introduce two types of perturbations, an initial-state perturbation and an updating-rule perturbation. Given a Boolean network initialized with v1(0), v2(0), …, and vN(0), the initial-state perturbation at a node viÎV means flipping vi(0) to . On the other hand, the updating-rule perturbation at a node viÎV means switching the updating-rule at vi from a conjunction function to a disjunction function or vice versa, depending on the current function type. Assuming a perturbation at vi, we define the effectiveness from vi to another node vj, e(vi, vj), as follows:
- Let τi, the valid convergent time of vi, defined as τi = max{Ti, T'i} where Ti or T'i represent the time steps for the network to converge to an attractor when vi was subject to the perturbation or not, respectively.
- We obtain two different transient sequences of vj, vj(0,τi) and v'j(0,τi), when vi was subject to the perturbation or not, respectively.
- Then, we compute e(vi, vj)=d(vj(0,τi), v'j(0,τi)) / τi where d(∙) means the Hamming distance (i.e., the number of bits having different values) between two sequences. Thus, e(vi, vj) represents how largely the trajectory with respect to vj was affected by the perturbation at vi. This also measures the mutational effect of vi to vj.
Fig. 1. An illustrative example of calculating effectiveness in a Boolean network. A Boolean network with 8 nodes and 14 links where arrows and bar-headed lines represent positive and negative interactions, respectively. 'AND' and 'OR' denote conjunction and disjunction update functions, respectively. Trajectories starting from an initial state (11010010) and another state (11011010) where v4 is subject to an initial-state perturbation. States of the network (i.e., eight-bit strings in rectangles) represent values of v0 through v7 in sequence and grayed rectangles with dashed lines mean attractors. These states and trajectories are calculated from the network. Then, effectiveness from v4 to v7 with respect to the trajectories was computed
Therefore, effectiveness is a measure about how largely each node is affected by perturbation at the other node in terms of dynamics. In a Boolean network, a node is called a functional important node if a perturbation at the node makes the network converge to another attractor, which is different from the original attractor to which the network converged when the node was not subject to the perturbation. In this regard, disease genes can be considered as important nodes in signaling networks and the effectiveness in Boolean networks can be used to represent the effectiveness on candidate genes when known disease-associated genes are mutated in signaling networks. Figure 1 shows an example of the calculation of effectiveness of v4 to v7. To compute e(v4, v7), we get two transient sequences of v7, v7(0,τ4) and v7'(0,τ4), when v4 was subject to a perturbation or not, respectively.
Effectiveness from a set of nodes to a node in arandom Boolean network
In a similar way, given an initial state, the effectiveness from a set of nodes S to a node can be calculated by applying perturbations on all nodes in the set simultaneously, and then the effectiveness from these nodes to a node vje(S, vj) is calculated. For a set of initial state Is, the effectiveness from a set of nodes to a node is formally defined as following:
For the identification of disease-associated genes, S is a set of known genes of a disease of interest, vi is one of candidate genes, then measures the effectiveness from known disease genes to a candidate gene. Therefore, candidate genes can be ranked to be associated with the disease of interest by this measure.
A. Random Walk with Restart (RWR) algorithm
To show the advance of our proposed method, we selected a state-of-the-art network-based method, which is based on a random walk with restart (RWR) algorithm. RWR is a variant of the random walk (50) and it mimics a walker that moves from a current node to a randomly selected adjacent node or goes back to source nodes with a back-probability gÎ(0, 1). RWR can be formally described as follows:
where Pt is a N´1 probability vector of |V| nodes at a time step t of which the ith element represents the probability of the walker being at node vi∈V, and P0 is the N´1 initial probability vector where the value of an element corresponding to a non-source node or a source node is zero or 1/|S|, respectively. S is the set of source nodes. The matrix W' is represented by a transition probability matrix and thus (W')ij, the (i, j) element in W', denotes a probability with which a walker at vi moves to vj among V\{vi}. Formally, for an unweighted network, it is defined as follows:
where (Vout)i is a set of outgoing nodes of vi.
Fig. 2. Comparison of performance between BoolDGP and RWR. The performance of two methods was assessed using LOOCV method on the set of 25 disease phenotypes from OMIM. For BoolDGP, initial-state perturbation method and a set of 100 initial states were used. For RWR, the back-probability was set to 0.5.
All nodes in the network are eventually ranked according to the steady-state probability vector P¥, which is obtained by repeating the iterations until ||Pt+1-Pt||<10-6 in this study.
For the identification of disease-associated genes, S is a set of known genes of a disease of interest, an element of P¥measures how much relevant to S a gene in the network is. Therefore, it is the degree of association between a candidate gene and the disease of interest.
Performance Evaluation
Ranking performance was assessed through the leave-one-out cross-validation (Shortly called LOOCV) process. For each disease phenotype (d), in each round of LOOCV, we held out one known d-associated gene. The rest of known d-associated genes are specified to a set of source nodes (i.e., S). The held-out gene and remaining genes in the human signaling network, which were not known to be associated with d, were ranked by the two ranking methods. Then, we plotted the receiver operating characteristic (ROC) curve and calculated the area under the curve (AUC) to compare the performance of these two methods. This curve represents the relationship between sensitivity and (1-specificity), where sensitivity refers to the percentage of known disease-associated genes that were ranked above a particular threshold and specificity refers to the percentage of genes which were not known to be associated with a disease ranked below this threshold.
Performance Evaluation
To assess performance of BoolDGP in ranking disease candidate genes, we randomly selected Is = 100 initial states and used LOOCV to draw the ROC curve and calculate AUC value for the set of 25 disease phenotypes collected from OMIM (See Materials and Methods section). To compare the performance of our method with that of RWR-based method, we follow the same procedure as did for BoolDGP, and set the back-probability to 0.5 since the performance of the RWR-based method is stable with the changing of the back-probability parameter (24). Figure 2 shows the performance of the two methods, it is clear that BoolDGP (AUC = 0.77) outperformed the RWR-based method (AUC = 0.73). This result implied that the disease gene prioritization problem can be approached effectively with the hypothesis that the mutation on known disease genes of a disease of interest affect other genes and this effectiveness can be used as the degree of association between candidate genes and the disease of interest.
Case study: Breast cancer
In this section, we show the ability in predicting novel genes associated with specific disease. In particular, we test our method with breast cancer (OMIM ID: 114480), this is a complex disease with 22 known associated genes. However, only ten of them are available on the human signaling network. Using these known genes as source nodes and considering other genes in the network as candidates, we calculated the effectiveness from these known genes to all the candidate genes. Candidate genes then are ranked based on the effectiveness. We selected 50 highly ranked candidates to find evidences of their association with breast cancer from literature. Interestingly, a total of 27 among them have at least one evidence to be associated with breast cancer (Table I). For example, a study showed that genomic rearrangements of the CHK1 gene is associated with breast cancer (51). Also, polymorphisms/haplotypes in GADD45A contribute to breast cancer risk, at least to sporadic breast cancer (52). In addition, high expression of HBEGF is related to the biological aggressiveness of breast cancer (53). mTOR is a critical target for survival signals generated by phospholipase D in breast cancer cells (54). Other candidate genes in the top 50 can be promising ones for future studies.
Table 1: A total of 27 among top 50 ranked candidate genes are evidenced to be associated with breast cancer from literature
Entrez Gene ID
Gene Symbol
PubMed ID
20567916, 21401699, 21752283, 23844225
15735726, 18350249, 19728081, 23158659, 23706118
21741997, 23065795, 24625971
17962208, 24013225
15448190, 15590693, 19724859, 25377473
16650817, 16925462, 19074826, 19543320, 19795460, 24177339, 24568471
12813467, 15580312, 17631500, 17911267, 18612547, 18652687, 18787170, 18831768, 20030877, 20459645, 20479250, 21046231, 21963359, 22349822, 23991038, 24323026, 24630930, 24637915, 25659153
15590693, 17512111, 18668364, 19875955, 21868756
18990689, 21478909, 24407288
15492785, 16807677, 16821086, 17259657, 17262178, 17592771, 17726138, 19671875, 20204503, 20428939, 20720556, 21409393, 21671140, 21872972, 24265520
12088102, 22238610, 22622474, 23542172
20394500, 21392388
17515959, 18625725, 18652687, 18725974, 19269083, 19471547, 20030877, 20226014, 20458733, 23500535
11960991, 20657189
19890961, 24958351
18317451, 20198332, 23562764, 24825907
22404826, 24911119
11788906, 11916966, 11936586, 14612409, 15202008, 15545228, 16179497, 16525654, 18413362, 18586674, 19380022, 19501078, 19596972, 19787269, 20056641, 20225759, 21411498, 21526393, 21627565, 21911295, 21949822, 22037553, 22134622, 23065203, 23158658, 23629941, 23677713, 23741361, 24216762
15450420, 15849742, 16814250, 17446929, 21127199, 21933556, 22535334, 23443851
16026775, 17035597, 23524337
17985201, 20880986, 22559840
In this study, we proposed a novel network-based method for identification of disease-associated genes. This is based on Boolean dynamics of biological networks under a hypothesis that mutation on known disease genes of a disease of interest affect other genes through the network and this effectiveness can be used as the degree of association between candidate genes and the disease of interest. Simulation results showed that our method is superior to a state-of-the-art network-based method. Using the proposed method, we also predicted 27 novel breast cancer-associated genes with evidences from literature. In future study, besides the Boolean dynamics, we are going to integrate structural properties of biological networks to a measure of association between candidate genes and diseases of interest since some studies have shown special structural properties of disease genes in the biological networks.
This work was supported by Vietnam Institute of Advanced Study of Mathematic (VIASM), Ministry of Education and Training under contract number 76NC/2014/VNCCCT.

subset: commoncrawl


text:
NEW 360 degree Mini Prism with 4 poles for total stations high quality. 360 degree Mini Prism with 4 poles for total station. Pole Material: Aluminum Alloy. Pole diameter: 12 mm. For Robotic Total Station. 1X 360 Mini prism + 4Xpoles + Bag. ATR range of 350m. Content: 360 Mini-prism pole 4 + Soft Case. Shaft diameter: 12mm 4 section (single 30cm). In rare cases it may take longer to delay due to custom clearance or during the holidays. Your satisfaction is always our NO. The item "New Silver plated 360 degree Mini Prism for Leica ATR Total-station" is in sale since Saturday, March 17, 2018. This item is in the category "Industrial\Test, Measurement & Inspection\Levels & Surveying Equipment\Levels & Autolevels\Other Levels & Autolevels". The seller is "leitaiyq" and is located in . This item can be shipped worldwide.
- Brand: LETER
- Model: MINI360
- Bundle Listing: Yes


text:
Evidence, that the operator of an automobile started it when he knew that a guest had not yet entered it and while the guest still was on the running board, and then, after proceeding thirty to forty feet, stopped so suddenly that the guest was thrown through the air over the front fender and injured, did not warrant a finding that the operator was grossly negligent.
TORT. Writ in the First District Court of Eastern Middlesex dated May 12, 1941.
On removal to the Superior Court, the case was tried before Williams, J.
R. L. Ryder, for the plaintiff.
R. B. Snow, for the defendant.
WILKINS, J. This action of tort for personal injuries, received by the plaintiff while a guest rider on the running board of the defendant's automobile, presents the question whether there was any evidence of gross negligence. The jury returned a verdict for the plaintiff, and the judge with the jury's assent reserved leave to enter a verdict for the defendant. A motion of the defendant that a verdict be entered in accordance with the leave reserved was allowed by the judge subject to the plaintiff's exception.
The evidence, given entirely by witnesses called by the plaintiff, showed the following: The plaintiff, aged twenty-six,
Page 422
and the defendant, a physician of about the same age, who had been together watching a parade in Boston, late in the evening returned on foot to Salem Street, where the defendant's automobile was parked. The plaintiff started to walk home when the defendant, who had gotten into the automobile, opened the window, asked the plaintiff to get in, and said he would drive him home. The plaintiff said, "Yes, I will," mounted the running board to open the left rear door, and took hold of the glass in the front left window, which was open. He had just discovered that the door was locked when the defendant started the automobile. The plaintiff testified that "he started the car so fast I yelled to him, `Eddie, I am not in the car yet'"; and that the defendant made no reply, but "drove the car thirty-five or forty feet and I was still holding on and he stopped fast and I was thrown from the automobile." In his flight through the air over the left front fender the plaintiff broke off an aerial, and landed unconscious in the street about eight feet from the automobile, sustaining a fractured skull. One witness described the accident in these words, "the car started off sharply, probably went thirty, forty feet and stopped sharp, when it stopped short Mr. Polcari flew over the left fender in the air." Another witness testified that "she saw the car shoot out very fast, . . . that she would say that the car went thirty-five to forty feet before it came to a stop; . . . that she saw the plaintiff as he was shot off the car when it stopped, that it stopped very suddenly and that he, the plaintiff, `flew from the left front fender and landed out in the middle of the street.'" The defendant testified that he wanted to stop exactly in front of the door at 125 Salem Street, where he was to get his sister-in-law, who had a broken ankle; that he stopped "quite abruptly"; that he knew the plaintiff said something, but did not remember what it was; that he did not wait for the plaintiff to get in; and that he did know that the plaintiff was not in the automobile.
The judge's ruling was right. The substance of the case is that the defendant, with the purpose of running a few automobile lengths to a definite place, started "fast" and
Page 423
stopped "quite abruptly" without ascertaining whether the plaintiff was in a position of comparative safety. "Apparently he had the automobile under control at all times. There was no collision, no overturning, no departure from the course." Romer v. Kaplan, 315 Mass. 736, 737. Plainly no great speed was possible in the circumstances. The entire episode could have been of but few seconds' duration. The defendant's conclusion, erroneous as it proved, that he could safely proceed this very short distance and stop where planned without chance of injury to his friend, who was in the vigor of full manhood, did not constitute deliberate inattention or the voluntary incurring of an obvious risk. This case most closely resembles and is no stronger for the plaintiff than Forman v. Prevoir, 266 Mass. 111, and Byrne v. Daley, 288 Mass. 51, where it was held that there was no evidence of gross negligence.
Exceptions overruled.


text:
Read what some of our clients have to say ...
"Hi Chris, My sign just arrived, it is awesome. I will take a photo for you when we install it sometime in the next couple of weeks. Thanks so much" D. Bridson
"Hi Chris, We have finally installed our sign and looks great. We are very pleased with it. Have attached a photo. Thanks again for you prompt and efficient service, we are very impressed." J. Saunders
"Hi Chris, we are very happy with our sign. I appreciate your help and follow-up and would gladly recommend your services." T. Merambeliotis
"Hi Chris, Sign arrived yesterday and we are very happy with it. Friends and family have been impressed so far and once installed (level I hope) will send a photo. Our thanks to Sassysigns for making this project so easy." P. Kelly
"Hi Chris, the sign just finished off the house quite nicely. I could not find anything close in the retail stores that would have worked as well as this sign. Thanks again." J. Petrina
"Hi Chris, Just wanted to let you know sign arrived today. Its fantastic. We are thrilled to bits." B. O'Brien
"Hi Chris, I received my sign today and love it. Thanks for the great service and great product. My friend also received her sign last week and also said to say thanks, love it and it looks great on her house." L. Williams
"Thanks Chris, Jack absolutely loves it. It's perfect! and your customer service is flawless!" H. Palmer
"We are very pleased with the sign Sassy signs made for us. Their service was excellent, Chris took the time and trouble to visit the site and his input into the final design was invaluable. We highly recommend Sassy Signs" R. v.Hardeveld Chairman Owners Corporation
"Thanks for your quick response. Your service is excellent." L.Teh
"Parcel arrived this morning and looks good, will keep you in mind for future projects as service was excellent. Thank you" S. Martin
"Hi Chris. Yes I got the sign. It is awesome, better than I expected! I gave it to them this afternoon and they were really surprised and loved it." K. Aspinall
"Hi Chris, just thought I'd drop you a line with the pictures of the signs up. Thanks they look great!" B. Barnett
"Hi Chris. The sign looks fabulous!" J. Gainey
Some of our clients' photos ...
for more photos please go to our Facbook page www.facebook.com/sassysigns


text:
That is why we pay attention to machinery modernization and increase, which includes IMA best technologies, a group chosen by the top industries of the sector.
Like the carpenters of the past, we look for the best wood. We can process any kind of material, from solid to fine woods, getting different effects in combinations, as well as a wide range of colours.
In addition to one-off production, we provide you with a turnkey service, starting from the design and ending with the installation at the customer location. This is one of the reason why we offer you great flexibility at a very competitive price.


text:
In Traditional India, the astrologer was called upon for predicting wealth, good fortune, marriage, progeny, etc. But without Health, none of these other areas of life would be enjoyable. So the birth chart would always be examined for any upcoming health issues. The correlation between the planets, signs, houses, and diseases was established over many centuries of meticulous observation by the ancient astrologers. Modern astrologers continue this research today.
When considering natal health issues, the first step in analysis is to look at the Ascendant, the 1st house. The 1st house represents the body as a whole, therefore the strength of the 1st house is key to one's ability to stay healthy and to overcome disease. The basic principles of determining strength in the chart are applied: is the ruler of the Ascendant. There are specific houses and high indicate the Heath and help us Forster any medical condition. The main purposes to view the horoscope are listed below :-
An accident or mishap is an unforeseen, unplanned, unexpected and undesirable event, especially one resulting in damage or harm When a person meets with an accident and afterwards goes through the mental trauma, the 1st thing that comes to his mind on recovering is that he is having a bad time and/or the planetary positions are not favourable to him.
Everything that happens in the life of an individual is influenced by Planets. Road accidents have become quite common these days due to increase in traffic on the roads. In my opinion most of these accidents can be avoided and a good astrologer can advices better how to avoid these high risks moments of life.
Timing of accident
Transit also play an important role in deciding the timing of accident. Transit must support dasha periods. Accidents occur during the transit of malefic planets connected to malefic houses in the horoscope or the birth position of sun, moon and ascendant.
Injury and no injury
it can also be seen from the horoscope that where there would be any injury or not. We can foresee the major damage and work to reduce the effects of the planets which could cause major damage.
It is also seen that people suffer major accidents but still they face no injuries or minor injuries. If that's the case then we work on giving strength to the favourable planets of the native and reduce the ill effects of the malefic planets.
Major Injuries
Horoscope not only tells us the time of accident but also tells us whether it's going to cause major injuries / fractures or even seperation of any body part. With the help of astrology we can prevent the native from such a damage by pacifying the effects of Malefic planets so the damage that could be caused would be as minimal as possible.
Medical treatment Or Surgery
He who practices medicine without the benefit of the movement of the stars and planets will not be that beneficial.
Consulting an astrologer or researching your own planetary birth chart is beneficial for guiding your health. It is like having a map of your life, indicating your susceptibility to a particular disease or accident, the organs composing any weak links in your body's chain reactions, and your emotional attitudes that are causing a particular part of your body to attract an accident or infection; but most importantly, the timing of illness or possible accident, indicating when you would be the most vulnerable.
Your birth chart and current position of planets , dashas and antradashas and antradashas will provide the detailed information they whether the surgery would be successful or not or when is the preferred time of any medical treatment.
Multiple Organ Failure Or Bedridden
Astrology also tells us that whether after accident is the native going to be bedridden or will survive even after having multiple organ failure. Well I get to meet so many clients who approach us after their loved ones suffer from major accidents and they question us regarding their child not recovering or getting bedridden or getting paralysed.
People it's very important to consult your astrology on frequent basis. The way you go regular body checkups. It is also very important to consult your astrologer as frequently as possible to keep yourself updated about the unseen.
Sound Health is more precious than wealth because it enables you to enjoy life and work hard to accomplish your goals. Mental health is more essential to lead a peaceful life.
Each planet causes certain diseases according to its nature as detailed hereunder. The ailments may vary according to the sign and house it occupies . It can also be seen what kind of shot term( chronic diseases like cold, cough or headache )or long term disease (cancer, TB , cardiac diseases or lung )a native would go through. So that we can give remedies according to that.
Recoveryor Non-Recovery
Astrology also lets us known that even if the native has survived the major unseen damage then how fast would be recovery and which remedies would help in attaining recovery at a faster pace.
Non-recovery is a deep and bitter truth which let us know through astrology that what things are going wrong which are not letting the native to recover. Once the root cause is found, it becomes easy to eradicate it and help the native get into recovery stage.
Native and the loved ones have to be as patient and optimistic as possible. Miracles do happen and that's the reason we are here to communicate with the planets and guide you about it.


text:
- News and Current Affairs
- Features and Reports
- Useful information
- Our Shows
- Contest
In the first half of the 1940s, Romania and Germany were allies. In spite of this alliance, there were differences between them in regard to the way they treated Jewish communities
In the first half of the 1940s, Romania and Germany were allies. They were allies both on the frontline and in terms of anti-Semitic policies. In spite of this alliance, there were differences between them in regard to the way they treated Jewish communities
Germany applied a policy of gradual annihilation of Jews, which became more and more radical after 1942. It culminated in the so-called "final solution", with Jews getting deported and killed on a massive scale in the death camps in what is now Poland. Romania's anti-Semitic policy was inconsistent, starting with a radical attitude, but ending with a refusal to deport Jews to the camps.
Historian Ottmar Trașcă, with the "George Baritiu" History Institute of Cluj, outlined for us the relationship between Romania and Germany in terms of the Jewish issue in the first half of the 1940s. Ottmar Trașcă recalled that Romania was consistently anti-Semitic throughout the late 1930s and early 1940s.
In its race policy, the Antonescu regime had the full benefit of consultation with the Germans: "During the nationalist Legionnaire governing in 1940, the Antonescu regime initially adopted a policy of Romanization, and continued with this policy after the downfall of that government in January 1941. Starting in March1941, Romania had a counselor for Jewish issues, SS Captain Gustav Richter, working at the German Legation in Bucharest. What was his initial mission? He had arrived upon request from the Antonescu government, along with counselors for various other issues. His mission was to harmonize Romanian and German anti-Semitic policies. Later on, starting in the autumn of 1941, and especially in 1942, he was supposed to prepare the application of the final solution in Romania. Gustav Richter had a decisive role in all the anti-Semitic laws passed in 1941- 1942."
Romania and Germany collaborated closely in killing off Jews in Bessarabia, Northern Bukovina, Transdnestr and Odessa.
Ottmar Trașcă looked into the German military archives, where he researched the collaboration between the Germans and the Romanians: "Once war broke out between the Germans and the Soviets, the Jewish matter entered a new stage. Now we have cooperation with the German mobile extermination units, the so-called Einsatzgruppen, on Romanian territories, Bessarabia, Northern Bukovina and Transdnestr. There were 4 Einsatzgruppen that trailed German and Romanian operative units on the southern flank. Einsatzgruppe D was led by Col. Otto Olendorf, and their crimes were shocking, they assassinated over 90,000 people. When I looked at the daily reports sent to Berlin, they referred often to collaboration with the Romanian authorities. They very often said that they had 'very good collaboration with the army, gendarmes and police. The way in which the Romanian authorities and the Antonescu regime treated the Jews in Bessarabia, Northern Bukovina and Transdnestr was met with stupor by the German leadership, even by Adolph Hitler. On August 19, 1941, Hitler told Goebbels that 'in the Jewish matter, a man like Antonescu acts more radically than we have so far'. Such an appreciative statement made by Hitler tells a lot."
In June, 1942, the Romanian Government agreed to the deportation of the Romanian Jews abroad. Thus, 5 thousand Jews were deported to Auschwitz, most of them from France. Nevertheless, Antonescu's attitude would soon change.
Ottmar Trasca: "The situation changes in 1942. We know that in August 1942 the Antonescu government gave its approval for the deportation of all Jews from Romania, starting with the ones in the counties of Timis, Turda and Arad. Why didn't they get deported after all? First, there were the interventions of Wilhelm Filderman, that were very well constructed and motivated. Filderman used in his argumentation a very sensitive issue for Antonescu, namely, Transylvania. Filderman asked what the use was for deporting the Jews from Romania as long as Hungary did not do the same. The deportation of the Jews would have been to Romania's disadvantage in the competition between Romania and Hungary over Transylvania. Hungary had not deported any Jews and had rejected all requests in this respect. So Filderman's argument proved efficient. There were also the interventions of Baron Francisc Neumann, those of Iuliu Maniu, and of the Queen Mother Elena. Also, there was a firm American diplomatic note dated October 1942, conveyed through the Swiss Legation in Romania, in which the US Government threatened with reprisals against Romanian citizens in America unless deportations ceased. And, above all, there was Stalingrad, which was decisive for Antonescu's change in attitude. Antonescu was pragmatic and he understood, at least after Stalingrad, that Germany lost the war. Instead of deporting Romanian Jews to the death camps in Poland, as from December 1942 Antonescu had a change in the policies he pursued and agreed to the Jews' emigration to Palestine."
Romania and Germany cooperated in the Jewish extinction policy in WW II. In spite of the fact that the two countries had divergent opinions over the final solution, Romania is responsible for the deportation of the Jews.
Useful Links
Copyright © . All rights reserved


text:
Decagon Safari: Completer Wildlife Safari
Tour duration: 3 Days / 2 Nights
Starting from: USD $7100 per person based on two travelers
Cost per person:
1 Person
2 Person
3 Person
4 Person
5 Person
6 Person
7 Person
8 Person
Single Room Supplement: USD $250
This is a 10 Days Kenya Safari to the world famous Masai Mara Game Reserve; Kenya's finest wildlife sanctuary with well over 450 animal species. You also have the option to book a balloon ride (400US$ per person additional).
Day One: Nairobi – Amboseli
Sweeping across the Kenya-Tanzania border, the savannah grassland of Amboseli National Park is your playground for the day. This morning you'll meet with your guide and set out into the park for a chance to share the terrain with some of the world's most elusive animals. You have the option to do your game viewing either before or after check-in, so call upon the knowledge of your expert guide for their recommendation based on your arrival time and park hours. This afternoon you'll meet with your guide and head to Amboseli National Park. The park is famous for being the best place in Africa to get close to free-ranging elephants among other wildlife species, and its other attractions include opportunities to meet the Masai Tribe's people. On a clear day, you'll also have spectacular views of Mount Kilimanjaro, the highest free-standing mountain in the world. Dinner and overnight at the Kibo Safari Camp.
Kibo Safari Camp has 73 self-contained tents for single, double, triple and family accommodation. The beds have been custom designed and locally made using bush logs and will ensure a good night's sleep! All tents have flush toilets, showers, and wash basins. You can enjoy your shower as you like: bubbling hot or refreshing cold. For the duration of your stay in the African bush, Kibo Safari Camp will be your home away from home! For the newlyweds, Kibo Safari Camp offers special packages which can be tailor-made to your requests. Do you fancy a romantic dinner by the pool under the stars? All meals can be taken in privacy away from the main dining area under the open skies. And even a surprise from the camp manager is included! Your honeymoon at Kibo Safari Camp will be an unforgettable experience!
Day Two: Amboseli – Namanga – Arusha
Today you will bid a fond farewell to Kenya as your guide drives you from Amboseli to the Kenya/Tanzania border crossing of Namanga. Meet your Tanzania guide. Visas can be purchased at the border: for Kenya it's a per person cost of 50$ USD, for Tanzania it's a per person cost of 100$ USD for American Citizens and 50$ USD for all other Nationalities. Please Note: Visas must be paid in USD, and in CASH. No bills can be older than 2006 as a local counterfeiting safeguard. A Single entry Visa is valid for 3 months and can be used for multiple entries into Kenya and Tanzania. It is also required that you have your Yellow Fever certification handy upon crossing. Enjoy a box lunch while you travel (included in tour price). Overnight at Roika Hotel Arusha.
Welcome to Roika Tented Lodge – lying in a unique flora & fauna of shrublands and acacia woodlands with hearty Baobab trees strewn around. Welcome to the birds' paradise of over 500 bird species. Roika Tarangire Tented Lodge is situated roughly 125km from Arusha town and is ideally accessible by Dodoma Road although it can also be reached by air since there is an airstrip just nearby in the Park.The lodge lies nestled on the banks of Tarangire River and a mere 5km away from the main entrance to Tarangire National Park. The lodge is also within driving distance to Lake Manyara and the famous Ngorongoro Crater.
Each one of the 21 luxury en-suite tents has a unique theme with beautifully handcrafted furniture and uniquely built animal shaped baths as well as showers. Every tent has got coffee making facilities for the self preparation of a cup whenever you desire and of course, a private balcony that affords you a relaxed view of Tarangire's Wilderness. Shopping in the Curio Shop for memorable souvenirs, antiques and/or Safari books.
Day Three: Arusha – Ngorongoro
Your guide will meet you at the reception at an agreed time and you will depart to Ngorongoro. It will take three hours and a half to reach the crater rim itself. The Ngorongoro Crater is the world's largest inactive, intact, and unfilled volcanic caldera. This geological masterpiece was formed as a result of an extremely large volcanic explosion which caused the volcano to collapse in on itself, thus creating a crater. The crater is roughly 20 kilometers wide and some 2000 feet deep, making the trip from crater floor to rim around 45 minutes by 4×4. The extremely fertile crater floor is the reason why there is such a highly concentrated amount of wildlife here.
Over 20000 mammals call the crater home, including some of the only remaining black rhinos in the world. The crater floor also boasts one of the highest carnivore densities in the world including large pride of lions, packs of hyenas and solitary predators like cheetahs and jackals. A keen eye and expertly recommended search patterns from your guide may help you spot some of the less common species like leopards, servals, and bat-eared foxes.
Overnight at the Rhino Lodge.
The lodge located on the edge of the Ngorongoro crater rim, Rhino Lodge offers a perfect base from which to explore the Ngorongoro crater and its surroundings. With 24 comfortable ensuite rooms, a cosy living space, friendly local staff and generous African-inspired meals, Rhino Lodge welcomes guests to Africa's most remarkable game park.
There are 24 guest rooms, all with a verandah overlooking a stretch of high montane forest. Each room has its own shower, toilet and hand basin. To keep away the cold each room has a wood-burning stove, and hot water bottles can be filled if you want one.
Day Four: Ngorongoro – Serengeti
Your guide will pick you up from the Ngorongoro Conservation area and drive you to the famous plains of the Serengeti. On this drive, you have the option of stopping at Olduvai Gorge, the Serengeti welcome centre and lookout point or stop for lunch at a picnic spot. After entering Serengeti Park you will have the chance to enjoy game viewing as you drive through the park to your next accommodation. This drive takes 5 hours depending on the number of stops you make and how much game viewing you enjoy along the way. The massive Olduvai Gorge or Oldupai Gorge is often referred to as "The Cradle of Mankind." Beginning in the eastern Serengeti plains, the gorge is roughly some 48 kilometres long. Resulting from millions of years of natural erosion, this gorge boasts a steep-sided ravine that cuts and stretches its way through the Great Rift Valley along eastern Africa. The gorge is named after a commonly used plant by the Masai people with the scientific name of Sansevieria-Ehrenbergii, or Oldupai for short.
Overnight would be at the Serengeti Serena Lodge. Serengeti Serena Safari Lodge has been designed to blend seamlessly into the landscape of acacia groves and sparkling streams. The 65 guest rooms and one suite are housed in clusters of traditional domed "rondavels" arranged around the lodge's stunning infinity pool. Set high on a hill with the rolling plains below forming a natural amphitheater, your room offers a ringside seat for the greatest show on earth, the annual migration of the wildebeest. Sweeping views, traditional stone-built and thatched architecture and private balconies immerse you in the stunning beauty and solitude of Serengeti National Park like no other accommodation can.
Day Five: Serengeti
This morning's African adventure begins with an exploratory game drive through Tanzania's oldest and most recognized National Park, the Serengeti. This location offers the most expansive game viewing in Tanzania. From predators to prey, great herds of grazing herbivores to tactically cunning packs of carnivores, life on the plains of the Serengeti can best be defined as a complete "circle of life." A photographic dream unfolds before your eyes as giraffes and elephants feast on tasty shrubbery, whilst impalas, gazelles and buffaloes dance carefully through the plains as to not become the latest meal for on-looking lions, cheetahs and hyenas. Spend today searching out Impala, one of Africa's most beautiful and graceful animals. Previously thought to be part of the gazelle tribe, Impalas have been found to be so different that they are now classified as their own sub-family status. When frightened or startled the whole impala herd starts randomly leaping to confuse their predator. They can jump distances more than 10 meters (33 ft.) and 3 meters (9 ft.) high. Leopards, cheetah, lions and wild dogs prey on impala. Impala can reach running speeds of approximately 50 to 55 mph (80 to 90 km/h) to escape its predators. See if you can track these incredible animals! Accommodation: Serengeti Serena Lodge.
Day Six: Serengeti – Isebania – Masai Mara
We will drive you from Serengeti to the Isebania border. Once there, you'll meet up with your Kenyan guide and continue into Kenya to the Masai Mara. This full-day commute includes game viewing in Serengeti and Masai Mara. The excursion will include a multi-hour drive across the highway and bumpy patches of road to the border. You'll have the option to enjoy a boxed lunch at Lake Victoria, visit a local fishing village, or simply drive straight to the border. NOTE: This is a scenic drive through rural East Africa. A good part of this drive cuts across the national park so there is plenty of opportunities to still see amazing wildlife.
Depending on your camp location and the stops on your game drive along the way, the drive to the Isebania Border is anywhere between 3-5 hours. When travelling across the Kenyan-Tanzanian border a few things must occur. Upon arrival to the Isebania Border Crossing, you will switch vehicles and guides according to the country you'll be entering. After the Kenya/Tanzania border crossing, continue on to the Masai Mara with your Kenyan guide and vehicle. This last section of driving will be partly on a highway and partly by dirt road. The last hour by dirt road can be longer in a rainy season. Enjoy game viewing on the way to your lodge. The approximate total travel time between Masai Mara and Serengeti can range between 6 to 9 hours depending on road conditions, traffic and weather.
Overnight at the Siana Springs Camp. Just eight kilometres from the main Masai Mara National Reserve, Siana Springs offers a uniquely personal safari on the edge of the world's most celebrated wilderness. The special tented camp offers 38 spacious tents situated in three secluded 'wings':
The tents boast the very latest in luxury camping, with large single or double beds, personal closets, writing desks, and ensuite bathrooms with flush toilets and steaming hot showers.
Day Seven to Eight: Masai Mara
Just like the local wildlife, you'll head out bright and early this morning, alongside an experienced tracker-guide for the day's first game drive. The eco-diversity and sheer size of the Masai Mara Game Reserve provide the necessary requirements to house a wide range of animal species. The most recognized are known worldwide as the African Big 5, which includes the African Elephant, Cape Buffalo, Rhinoceros, Leopard, and the King of the beasts, the Lion. The term Big 5 was coined by big-game hunters, as these species were the most difficult and dangerous to track and hunt. Subsequently, the term was adopted by the tourism industry for marketing purposes, spinning a web of positivity opposed to the negative effect portrayed by the original terminology.
Numerous other species of bird and wildlife inhabit this dynamic location including Hyenas, Gazelles, Impalas, Giraffes, Zebras, Vultures, Cranes, Eagles, Falcons, and Ostriches. Head out this afternoon, accompanied by an experienced tracker-guide, on an exciting game viewing adventure. Search some of the area's wildlife hot-spots, determined by your guide, as have an understanding of the games daily routines through tracking. Some wildlife, for instance, the Leopard, is more difficult to spot than others. These spotted cats blend almost seamlessly into the tall grass and shrubbery and are even more challenging to spot up in their favourite hangouts, the trees. Your guide will take you to nearby watering holes, where on a hot day you'll spot many bird and wildlife species, including the elusive Leopard.
Overnight at the Ol Moran Camp. This is an exclusive tented camp for those who want to be true to wild experience. The camp is situated within the Masai Mara Eco-system and on the banks of Ololaimutia River which is a watering point for most of the wild animals especially elephants, buffalos, antelopes etc. It is located 20 Kms from Keekrok Air Strip, 15 Kms from Sekenani Gate, 2Kms from Ololaimutia Gate and 230kms from Nairobi. Masai Mara the new seventh wonder of the modern world, famous for the migration of wilder beasts.
Day Nine: Masai Mara – Naivasha
Your guide will drive you from Masai Mara to Naivasha, which will include short stop-overs for refreshments and souvenirs. This drive will take approximately 5 hours. Sign up for optional activities on-site. Activities include Crescent Island boat tour, hiking and day trip excursions to Mt Longonot and Hell's Gate, or simply walk along the lakeshore and relax at Lake Naivasha Crescent Camp
Lake Naivasha Crescent Camp is located on the shores of Lake Naivasha at the heart of the Kenyan Rift Valley, only 90 minutes' drive from Nairobi. The camp is constructed using canvas and has a capacity of 20 luxury tents. The tents are well furnished, have wooden floors and adequate space generously created to allow free movement inside and outside at the guests' comfort. Our luxury camp is constructed using canvas, all tents have en-suite bathrooms with hot and cold running water and flushing toilets. The tents have an ambience and style decorated to give them traditional tent look with all the comforts of home. We are proud of our cuisine which gives an appetite even to those on diet.
Day Ten: Naivasha – Nairobi
A local guide will drive you from Lake Naivasha, along with the beautiful Rift Valley, to the urban city of Nairobi. This drive will take 1 and half hours and be dropped off at the airport.
N.B. If you like, we can make reservations for dinner at a local restaurant as well. Please let us know in advance and if you are vegetarian.
Hortensia Adventures is Tour Operators and Agency Based in Tanzania, Zanzibar, and We offer Tanzania Safaris, Mountain Trekking (Especially Mt. Kilimanjaro, Mt Meru) and Holidays
We passionately believe in the power of travel to broaden the mind and build bridges between people. By sharing with people the attractive places not mentioned in guidebooks, the local people you wouldn't otherwise meet and the traditions you may not have experienced by yourself, we ensure that people get the 'insider' view, an authentic and enhanced experience.
We have the ultimate team to find and arrange safaris, holidays and adventures in Africa. We offer a highly personalized and professional service ideal for individuals, families and groups.
Website of Hortensia Adventures Mountain Climb and Safari
Hortensia Adventures Trekking and Safaris
P.o.Box 8595, – Moshi, Tanzania
We are a tour group agency located in Uganda. We offer a variety of tour programs for our international guests in East Africa; including but not limited to Uganda, Kenya, Tanzania and Rwanda, a nation that recently became part of the British Commonwealth. We also conduct tours across Southern Africa i.e. Zambia, Botswana, Namibia, Zimbabwe, and South Africa.
Our primary objective is to give a tourist or tour groups the adventure of a lifetime by sharing the natural wonders Africa has to offer. Kubwa Five Safaris provides a safe environment while at the same time exposing you to interactions with wide varieties of our land animals in their natural habitats within a safe distance or close proximity with strict regards to your safety.


text:
Black Layered High Low Top
Thanks for signing up for restock notifications!
There was an error signing up for restock notifications. Please try again.
Fabric is very fabulous and luxurious. Superior material with a rich rich appearance. You will love this one. Zipper in the back gives you easy on and off. Combination of polyester and spandex for stretch. Runs very very true to size. Wear with jeans, slacks or leggings. Front measures 28 inches long and back measures 59 inches long. Sleeves are elbow length. I am 5 foot 7 inches tall and the back touches the floor on me with flats. The model in the photos is 5 foot 11 inches tall and has on at least 3 inch heels. Ships for Houston Texas by Social Butterfly Collection.
QUESTIONS & ANSWERSAsk a Question
Will you restock in a size 8?
We may get more in a week or two. We will email you when they are back in stock. Thanks
Will you get this in any other colors?
I think we may get black and burgundy. We are waiting to hear back from our manufacturers.
Will you be getting this in a size 22
Yes. We will email you when they are back in stock late next week. Thanks


text:
Rudy's New Human32
Life was good for Rudy the doguntil the new baby arrived . . .
Rudy loves being top dog in his family of three. When Rudy's human parents tell him that they are having a baby, Rudy thinks the newest member of the family will be interested in the same games he likeschewing bones, chasing cats, and playing fetch. But Rudy's new human is not what he expected! The baby cuts into Rudy's naptime, gets him in trouble, and, worst of all, steals the spotlight! Will Rudy ever find his place again in his family now that he's sharing it with the new human?
Rudy's New Human is a sweet and humorous story that helps older siblings to learn to share parents' attentionand maybe even become friends with a new family member.
Sky Pony Press, with our Good Books, Racehorse and Arcade imprints, is proud to publish a broad range of books for young readerspicture books for small children, chapter books, books for middle grade readers, and novels for young adults. Our list includes bestsellers for children who love to play Minecraft; stories told with LEGO bricks; books that teach lessons about tolerance, patience, and the environment, and much more. While not every title we publish becomes a New York Times bestseller or a national bestseller, we are committed to books on subjects that are sometimes overlooked and to authors whose work might not otherwise find a home.
Product Details
|Sky Pony
|Publication date:
|Product dimensions:
|9.10(w) x 9.00(h) x 0.50(d)
|Age Range:
|3 - 6 Years
About the Author
Roxanna Elden has been a teacher for eleven years and is the author of See Me After Class: Advice for Teachers by Teachers. Her inspiration for Rudy's New Human came from watching her dog, Rudy Elden, as he adjusted to having a new baby human in the house. She lives in Miami, Florida.
Ginger Seehafer is an illustrator who works as a commercial storyboard and concept artist in the Chicagoland area. She studied at the American Academy of Art and started her art career as a caricature artist at Great America. Ginger loves making art that inspires joy and creativity, especially in children who may become future artists themselves. She lives with her husband, two little humans, and two cats in Roselle, Illinois.


text:
CLIXAbu Dhabi, United Arab Emirates
CLIX – the Climate Innovations Exchange, launched in 2018, supports the UAE's Ministry of Climate Change and Environment strategy to enable the sourcing and funding of climate change solutions and technologies. CLIX is a unique global marketplace located in Abu Dhabi, UAE, a World Future Energy Summit initiative and a part of Abu Dhabi Sustainability Week's Youth for Sustainability (Y4S) hub, connecting youth, entrepreneurs, innovators and investors on a global level to enable partnerships that will power climate change solutions through knowledge, innovation and funding. In 2018, the 27 finalists exhibited their inventions at CLIX Marketplace in Abu Dhabi, and met with investors, resulting in nearly half the finalists receiving funding pledges from investors, totalling more than $17.5 million.


text:
Choose "Make this ad premium" at checkout.
Check with seller Major Vehicle Exchange Zephyr Cove
- Location: Zephyr Cove, Nevada, United States
Established in 1985 we are one of the largest and
oldest licensed dealers specializing in the sale of
reconditioned and road tested used shuttle buses,
commuter buses, coach buses, commercial transit and
paratransit buses and wheelchair mobility buses and
vans to churches, tour and shuttle operators, schools,
teams, resorts, assisted living facilities, adult &
senior care facilities and medical transportation providers
throughout the United States and Canada.
Some of our buses are converted into limo buses,
band buses, mobile offices, classrooms and showrooms.
We offer independent inspection services to our out-of-town
customers for total assurance of buyer satisfaction.
Our large inventory of fairly priced vehicles includes the
finest available shuttle buses, church buses, tour buses,
used buses, wheelchair vans, limo buses, charter buses and
ADA adult mobility vehicles with gas and diesel engines.
We are always looking for good used buses. Many of our buses
are sold directly to other dealers and brokers.
We own and have on hand all the vehicles presented here
on our website www.getanybus.com
Click here for More details....
Useful information
- Avoid scams by acting locally or paying with PayPal
- Never pay with Western Union, Moneygram or other anonymous payment services
- Don't buy or sell outside of your country. Don't accept cashier cheques from outside your country
- This site is never involved in any transaction, and does not handle payments, shipping, guarantee transactions, provide escrow services, or offer "buyer protection" or "seller certification"
Related listings
Windshield Glass Repair Near San JoseOther Vehicles - San Jose (California) - May 22, 2020 12.00 Dollar US$
Why should we replace windshield when it can be repaired at a low price? Come at LG Auto Glass to get your broken and damaged windshield glass repair near San Jose at the best price. All the technicians at LG Auto Glass are experienced, skilled, and ...
Car Decontamination Service in the USAOther Vehicles - Hawi (Hawaii) - May 22, 2020 96701.00 Dollar US$
Car decontamination not only cleans overspray from your car but also reduces the risk of exposure and harmful germs. If you want the best car decontamination service then come at Just Like New Overspray Removal Inc. for the best decontamination...
window repair San JoseOther Vehicles - San Jose (California) - May 21, 2020 12.00 Dollar US$
If due to any reason, the window of your car has been broken or one of your automatic windows is not working well then repairing or replacing it on time is essential in order to prevent your car from thieves. Get the services of window repair San Jos...


text: There are some folks who just get the job done. Others say they will do this or that, and don't — they simply collapse back on themselves, and just thinking about the thing they aim to do tires them. Then there are people like Glen Lamontagne, who charge ahead tirelessly, bringing order out of chaos, . . . → Read More: Bread of the Month: Pressing forth aboard the tortilladora


text:
A True Hybrid Agency
We're a hybrid agency that covers the entire marketing spectrum. But this isn't just a claim to fame — it's in our DNA. Since 1997, we've handled print, direct, and outbound marketing while introducing social, digital, and inbound marketing over the past decade.
Why do we offer both traditional and modern marketing services? By keeping our agency on the cutting edge, you can keep your company growing. It's that simple. Check out some of our most popular client services:
Drawing customers to your brand sounds better than berating them with an old-school marketing megaphone. It works better, too.
Creating a unified and more seamless experience for your customers will not only keep them hooked, but coming back for more.
Your brand is more than your logo and company colors. Your brand is your story, and a story is only great when it's delivered well.
In a world where online reviews determine a yes or no from a customer, it's crucial to keep your company painted in a positive light.
Speed wins. The first company to respond to a customer request wins the business 42% of the time. Has your team adjsuted to this level of sales pressure?
Photography &
From social media videos to website images, rich media gives your brand a creative punch through highly-engaging online elements.
Social Media
If your brand is not consistently engaging on social, you're doing it wrong. As a powerful content tool, high-quality social media is a must in the modern market.
Paid search, website updates, content creation, data reporting—digital marketing is a beast that most brands can't tame. The good news? You don't need to.
While we eat, breathe, and live digital, our roots lie in print, direct, and event marketing. From trade shows to billboards, we're more than equipped to handle your traditional marketing.


text:
Wayne Rooney has posted a Christmas video of himself with Coleen Rooney and their son Kai as dancing elves.
The trio used the ElfYourself website to achieve the transformation.
"Check out the ElfYourself video that I created with Coleen and Kai!" Wayne wrote on his Facebook page, with a link to the video.
The clip shows animated versions of the Rooneys dancing to a hip-hop take on the 'Dance of the Sugar Plum Fairy' from Tchaikovsky's The Nutcracker.
Coleen announced the sex of the couple's second child this morning.
"Absolutely loved seeing our baby on the scan yesterday!!!" she tweeted.
"We decided to find out the sex...... It's a ..... BOY!! So exciting @WayneRooney."


text:
Design for a Change in Perspective: Embracing Client Perspectives in Humanitarian Project Design (IRC, Oct. 2017)
|Post date
|Monday, 13 November, 2017 - 10:36
|Document Type
|Content Themes
|Accountability to Affected Populations
|International Rescue Committee (IRC)
|Filed under
|Accountability to Affected Populations and Protection from Sexual Exploitation and Abuse
There have been repeated and increasing commitments for over twenty years from the humanitarian community to increase its engagement with crisis-affected populations. These commitments include pledges to listen, collect and use the views and perspectives of crisis-affected populations to inform decision making at all stages of the programme cycle. However, studies and analysis conducted over the past years have shown little progress in the way people affected by crisis can effectively influence what, how, where and to whom aid and services are being delivered. Humanitarian agencies still face a number of operational and conceptual challenges to develop and implement client-responsive programming and to be participatory in the design, implementation and evaluation of their project interventions. These challenges are particularly pronounced during the design phase of humanitarian interventions.
The International Rescue Committee (IRC) is implementing the project, Designing for a Change in Perspective, under its commitment to strengthening the client-responsiveness of its programming and influence and support changes amongst its peers and donors across the humanitarian sector. The project intends to better enable humanitarian agencies to collect and reflect the perspectives of those they serve – their clients – in their project design decisions. This report shares the IRC's learning about the current practices, opportunities and the challenges humanitarian agencies encounter in collecting and using client perspectives in the design of humanitarian projects.


text:
About this event
This event is part of the 'All Dayer for Web Makers' event. Why not attend for the whole day?
Jack Franklin - A red LEGO brick is always red: components on the web
This talk will explore the changes that have occurred in the front end space in the past few years and how we've aligned on the concepts of components being the key building block for frontend applications.
We'll discuss how thinking of a web application as a tree of components, rather than discrete pages, leads to a more testable, maintainable and reliable codebase. We'll look at how we can build predictable components, encapsulating perfectly the triumvirate of HTML, CSS and JS that can be combined to build reusable components.
Using React as our component library of choice, we'll look at patterns that lead you down the path of reusability almost by default and how to walk the fine line between reusability and death by configuration.
Then we'll explore the final piece of the puzzle: CSS. CSS goes against everything the componentised world stands for but its global, cascading nature can be tamed. I'll show different approaches to combining your CSS with your components in order to fully encapsulate a component into a lovely, reusable lego brick.
Michelle Barker - Super-powered Layouts with CSS Grid and CSS Variables
CSS Grid Layout has the ability to transform the way we build layouts on the web and has made things possible that were never possible before. This talk will provide an overview of the various methods for building layouts with CSS Grid and demonstrate how it can help us construct complex components.
Michelle will discuss how CSS Variables (custom properties) can bring even more power to our CSS and give us finer control over our responsive grids, and how these dynamic variables can be altered in CSS and Javascript to afford some exciting possibilities.
When11:15am - 12:45pm, Friday 26th October 2018
WhereGuildhall, High Street, City Centre, Bath, BA1 5AW
Venue AccessibilityFully Accessible
Hosted By
Guildhall, High Street, City Centre, Bath, BA1 5AW


text:
View at Medium.com
Tag: Life Lessons
How to Write Without a Degree
View at Medium.com
30 Life London Lessons
I have yet to write about two months in London. It's actually embarrassing. Not that I consider myself any sort of "real" blogger, but I did hope that I'd have weekly updates on London life, what I learned, how I've changed (and I think (hope) that I have), and a bucket load of other things….


text:
Progress Report Day and Raider Time all week!
Bell Work: Take a look at Google Classroom as you have 4-5 assignments returned over the weekend.
Period 4: To Kill a Mockingbird continues…
Let's get right to it.
Period 5: Social Studies 20
€ I can explain how the United Nations came to be. 1.61
€ I can explain the mission and aim of the United Nations. 1.62
€ I can explain why governments and organizations felt that the United Nations was necessary. 1.63
€ I can explain how the U.N. Declaration is maintained and enforced. 1.64
€ I can explain how human rights are stated and upheld by the United Nations. 1.65
1. Who is often the first on the ground when disaster strikes?
The United Nations often deals in providing clean water, vaccinating children and aiding farmers- among many other things.
2. How did the United Nations begin?
Name some of the area the United Nations 'keeps the peace'.
3. How many child soldiers are in the world? approx…
4. How do they sustain peace?
5. What are the millennium development goals?
6. When is the target year?
7. Today more than ever the world needs United Nations.
-the consequences of a planet in peril
8. What is the UN doing about climate change?
9. What is the UN all about?
How powerful is Nato?
What is NATO?
Name 5 countries currently involved
How many member total make up NATO?
What does the agreement mean?
Compare and Contrast NATO and the UN.
Period 6: Photography Free-bie
It's time to create!
You were given suggestions on what to create for this assignment in your Google Classroom Pre-Video comments.
If you don't like that/didn't get a specific or want something more linear…
Create a half animal half human:


text:
Winter 1999
The Thousand-Year Itch
How do you get 10 scholars to wax anything but bored about the millennium? Scratch the surface of the Y2K hype and ask them to predict the future of their fields
Green Power
A 1969 article in The Varsity ignited students to start the Canadian environmental movement
Eye in the Sky
Ophthalmologist James Oestreicher circles the globe to treat patients in a converted DC-10
Stepping into the Future
Cutbacks in government funding for postsecondary education have eased off in the last couple of years; the Campaign for the University of Toronto is producing remarkable results, and a quarter of a billion dollars will be invested in new buildings and initiatives over the next decade.
An Inspired Appointment
Robert Birgeneau, alumnus and internationally acclaimed physicist, chosen U of T's 14th president
Salt-water solution
Isolation of a gene could improve farming productivity in areas of the world where crops are compromised by saline irrigation water
Playing Politics
Authors say popular English theatre troupe of 1580s was supported by the Crown
Caring for Caregivers
Study results suggest need for more in-home support services for grandparent caregivers
Given with GRADitude
Wheelchair-accessible picnic table is a gift from the department of occupational therapy's class of '98
Travelling Doctors Bag Nobel Peace Prize
Médecins sans frontières (MSF) is helmed by alum, Dr. James Orbinski
The Rose Wolfe Distinguished Alumni Award
Awarded to Dr. Chao-Shiuan Liu, vice-premier of the Republic of China (Taiwan)
Hong Kong Scholars
Foundation assists Hong Kong students pursuing undergraduate studies at U of T
The Naughty-Naughts
Celebrating the creation of the Faculty of Applied Science and Engineering


text:
People ask whether they can do a 'post office' Will, which is a make your own legal will kit, or whether they can do a 'simple' one page document.
The short answer is you can, the longer answer is it may not work and may create a different result to the one that you had intended.
Why is your Will document so long?
We don't merely make a long Will document for the sake of it, we are trying to cover a number of things in the longer Will document including:
- what happens if the house that forms part of your Estate can't be sold immediately because the banks have drastically changed their lending criteria?
- what happens if one of your beneficiaries dies at the same time as you, or shortly after you?
- what happens if the Executor needs to borrow money, for instance to fix something before it can be sold because of the prevailing consumer laws at the time?
What would happen for instance if the smoke alarms in your house weren't up to code, or the laws were changed so that all smoke alarms had to form part of a back to base alarm system. The correct terms in a Will can make a big difference, either saving the Estate money or saving the Executor themselves from having to argue with beneficiaries and defend themselves against accusations that they have failed in their duties.
We have acted for clients who have the right to take a certain action as a matter of legislation, but because an argumentative beneficiary cannot see that right spelt out in the Will it created unnecessary stress and delay.
But my Estate is simple
Most people think their Estate is simple, that the Executor won't have any of these problems, and everything will just go to the right person.
The problem is that the issues mentioned above aren't connected to how simple your Estate is. The property market could take a real dive shortly after you die, or your house could be slated for a significant rezoning, or the Executor could receive a compulsory acquisition notice. We also see the requirements of banks shifting in relation to Estates, or your Executor might have paid for your funeral or your Probate filing fee on a credit card and now wants reimbursement for the interest paid on that debt because obtaining Probate can take a long time.
Lastly a beneficiary could make a claim against your Estate, or somebody claiming to be a beneficiary (such as somebody claiming to have been in a romantic relationship with you) and your Executor has to manage the assets on an ongoing basis including re-investing or leasing assets.
It can make a significant difference to your Executor if you have properly prepared your Estate.
Estate planning is more than Wills
If you would like to receive more articles like this, then please join my mailing list for wills and estate planning, "Estate planning is more than Wills". Any new articles on these topics you will receive straight to your inbox.
Make an appointment
Come to us to get your Estate sorted out. It is so important, and it is so much more than Wills.
We are walking distance from Penrith Train Station, and we have ample parking.
We serve real coffee.
We speak plain English.


text:
Wooooooooooo! Today was my last day of massage therapy school! Now I'm just one national exam, one state exam and a buttload of annoying paperwork away from being a licensed massage therapist. Wooooooooooo!
November 23 2009 at 2:12 pm (Fun Stuff)
Tags: things that rock
Wooooooooooo! Today was my last day of massage therapy school! Now I'm just one national exam, one state exam and a buttload of annoying paperwork away from being a licensed massage therapist. Wooooooooooo!
November 20 2009 at 11:22 am (Words of Wisdom)
Tags: Amy Poehler, funny quotes, Parks and Recreation
"Guys love it when you can show them you're better than they are at something they love." -Leslie Knope, Parks and Recreation
November 17 2009 at 4:07 pm (Design & Decor, Fashion & Style)
Tags: accessories, fashion, home design, necklace
I'm getting ready to do some painting and design stuff in my house in the upcoming months and it's got me completely fixated on colors. So I'm making the most of it and trying out a new feature, "Live It, Wear It." Here's my first shot at presenting a particular color scheme in both home design and personal fashion.
Source: Ambertortoise
November 16 2009 at 2:37 pm (Photography & Art)
Tags: art, choose joy, etsy, french, handmade
I love this:
By evajuliet {via Katy Elliot}
November 16 2009 at 2:25 pm (Photography & Art)
Tags: erin tyner photography, etsy, pretty things
Erin Tyner Photography on Etsy {via SYL: Slipcover Your Life}
November 13 2009 at 3:45 pm (Music & Movies)
Tags: music, Neko Case, People Got A Lotta Nerve
Neko Case, "People Got A Lotta Nerve"
November 13 2009 at 3:38 pm (Design & Decor)
Tags: fey handmade, great gifts, handmade
Thanks to a post on Bliss the other day, I discovered Fey Handmade.
Inspired by nature and passionate about design, Fey Handmade began as a way to showcase the most beautiful handmade wares available today. Coming to fruition after much planning and hard work in 2008, they began hand selecting unique and inspiring finds to share through their site.
The Fey Handmade team works directly with designers to build a harmonious relationship that can grow into the future. The company started with the belief that great design should be easy to find, and great designers should receive support for all the wonderful things they create.
I highly recommend you check it out for some of your holiday gift giving.
Here are a few of my favorite items:
Under $10
Under $25
November 12 2009 at 3:42 pm (Music & Movies)
Tags: Avenue Q, Crazy Germans, Schadenfreude
I love this video, featuring the song "Schadenfreude" from Avenue Q. (Language NSFW)
November 11 2009 at 3:30 pm (Uncategorized)
Tags: facebook, Fail, logo fail, mom fail
November 11 2009 at 3:22 pm (Uncategorized)
Tags: "no homo", birthdays, decor, DIY projects, Thanksgiving table settings, wall art, wreaths
Wednesday afternoon! The work week's half over!
Morninggloria's hilarious area code breakdown or her past hookups had me cracking up at my desk this morning.
Are you a "more intelligent" or "less intelligent" googler?
Check Out
The City Sage offers up some beautiful ideas for Thanksgiving table settings. I think this one is my favorite:
If those settings seem a bit too decadent and beyond your price range this year, Apartment Therapy has some tips for a more budget-friendly turkey day.
For another way to decorate for the holidays without spending a bunch of your hard earned dough, check out these do-it-yourself wreaths made out of book pages.
And while you're at it, convert those toilet paper rolls into some great wall art.
This is a great idea that I will, unfortunately, never be able to execute. My adorable cat, Maggs, would make quick work of a wall full of thin cardboard.
This take down of the increasingly popular phrase "No Homo" is terrific. {via Splice Today}
And In Other News
Today is Veterans Day, so be sure to give a big thank you to any vets you know!
On a more personal note, today is also my mom's birthday. So happy birthday to my mama, who is the most wonderfully, fabulous woman in the world and hands down the greatest mom anyone could ever have. I love you Mom! Happy Birthday.


text:
التفريد العقابي ودوره في تحقيق العدالة الجنائية
بن طاهر, أمينة
مالكي, محمد الأخضر
MetadataAfficher la notice complète
My study about: "Individuality of Penalty and its Role in Realizing the Criminal Policy" "Comparative Study", dealt with the important questions of this subject about Islamic criminal policy and modern criminal policy, starting by the conceptual concretization of the principle to its projections following its types, finishing by mentioning its role in realizing the criminal justice. And to insure achievement of objectives of this study, I divided the research to two large parts, where I discussed in the first one about the concept of individuality of penalty and its concretization in the Charia and law, and in the second one, I presented types of individuality of penalty and the role of each one to realize the criminal justice, and I reached the following results: That the individuality of penalty is considered as one of the most important principles on which the good criminal policy is based, and on elements exploring its content, and also, is based on another principle having its weight in the domain of the sanction: "principle of proportionality", both according to Islamic or legal perception. The realizing of the principle of individuality of penalty and its elements demands existence of conditions and the most of them concerns the judicial system, and they are necessities that can helps it to realize desired criminal justice, and the most important one is the specializing of judge and its rehabilitating in one way, and the necessity of finding other voices helping him. The close connection between the principle of the individuality of penalty and criminal justice makes its importance in increase, and we have approved that the present connection is embodied in a relationship of integration between them, objectively and procedurally and teleology. We deliberately prove the real concretization of the principle of the individuality of penalty and we found that its application refers to Islamic criminal policy and its specific penal systems, this good policy based on fair foundations and searching to realize justice. In addition to this, the difference between criminal schools and their different programs, had a different impact in the report of the principle of the individuality of the penalty, although each one of them has its own vision about idea of justice.My study about three kinds of individuality of penalty: (legislative, judicial and executive), conforms to what is decided in the Islamic Charia and what is done by modern laws, making me appreciate that each kind has its own standards, mecanisms and reference on which it is based, and its effectiveness in realizing criminal justice. Also, adopting theory of summary procedures to speed up procedures to find solutions to conflicts is considered as one of the most important principles of Islamic legislation that the modern laws aim to expand its execution to find solution to criminal justice crisis. The achievement of the individuality of penalty and to insure the criminal justice depended from possibility of consolidating efforts of legislator and judge and executor together and the existence of important exigencies including materials that help each authority, to understand new forms of crimes and specifying criminal sanctions decided and leading to a solution to criminal justice crisis even using non criminal methods "consensual".
- Doctorat droit privé [52]


text:
Only 1 left in stock Last few items remaining
Item Shipped within 24 hours
Delivery in 4-5 days
Select size to see availability in stores Available Now in {{productdetailctrl.storesAvailabilityCount}} {{ productdetailctrl.storesAvailabilityCount == 1 ? "store" : "stores"}} Available in 3-4 days
Follow these 4 steps to measure your feet accurately:
Don't worry, you can return your item within 30 days for a full refund.
If you have any questions about fitting we think you should visit our customer service page.
(19 Reviews)
So comfortable and very good quality
Very comfortable and stylish. I bought them for walking to work and for casual wear. .
Love it!!!


text:
Avedo Gera GmbH: Our Call Center in Gera
Avedo Gera Location
The location in Gera was founded in May 2008 and employs its staff mainly in the inbound sector. We take over the customer service for well-known customers from the telecommunications as well as entertainment industry. Here, we process in-
coming commercial and technical inquiries of the customers. Together with our
works council, we always find the best possible solutions for both our employees* and our clients. Our location Avedo Gera is centrally located directly at the Gera Arcaden and offers free parking. We see ourselves as one big family - become a part of it too!
Avedo Gera GmbH
Hainstraße 10
D-07545 Gera
Tel.: +49 365.712 70
Calculate Route


text:
I am Oleksandr, Director and founder of the IBS company.
Let us start our dialogue with several seemingly easy questions: What does marketing mean for your company? Is it just handing out leaflets, or maybe billboard advertising? Who decides upon the ways of promotion for your product and upon its core value? Finally, the most common question: who is your target audience?
I could be asking these questions for a very long time. However, visiting our site means that you are on the right path to find answers. First and foremost, marketing does not consist in handing out leaflets or radio and billboard advertising; it is not even defined by promotion of the company using state-of-the-art Internet methods. These are all just means to an end. Marketing means a complex of methods, a big picture, strategy and tactics, a whole "orchestra" of various "instruments" aimed at achieving your goal. If you want to launch Internet, radio, or any other kind of advertising, but have no desire to look at the big picture, we will not be able to help you.
We are aiming our efforts at analyzing your company as a whole – from consumer research to lead processing. The whole range of marketing tools is employed in our work for maximum effect. However, the main thing is not launching an advertising campaign, but looking for and eliminating weak points in the purchase funnel.
Having analyzed the state of the market, I found that the number of personnel in Ukraine has decreased significantly, while talent has become much more specialized. Where previously a marketing manager was able to generate content, set up and adjust contextually targeted advertising, as well as perform simple designing tasks, now, when you hire a marketing manager, they will only be coordinating marketing purchases. In any event, you have to pay extra for the services of highly specialized professionals, or recruit a designer, an SMM manager, contextual advertising manager, etc. Unfortunately, the current circumstances are such that few small or medium-sized businesses can afford to increase the number of personnel. Still, such businesses must also have their chance to stay afloat and grow. Thus, I have developed a complex of marketing services to give such companies every opportunity to develop. These services are described below. We will gladly help to develop and propel your business towards greatness.
Thank you for your time,
Oleksandr Ivaniniv, CEO