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MAP-Best Execution Monitoring
MAP-Best Execution Monitoring service helps investment firms achieve extensive control and transparency over their order execution practices. As per Article 27 of MiFID II, investment firms should take "all sufficient steps to obtain, when executing an order, the best possible result for their clients taking into account price, costs, speed, likelihood of execution and settlement, size, nature or any other consideration relevant to the execution of the order."
To achieve the above, investment firms, among others, should arrange for the setup of thorough monitoring systems for the continuous evaluation of the actual execution quality delivered to clients. MAP-Best Execution Monitoring service helps investment firms perform this onerous and time-consuming task in an automated, unique and efficient way.
- Fully Automated Service;
- Web-based integrated dashboard providing a complete view of Best Execution monitoring analysis;
- Meeting regulatory requirements;
- Retrieve information from any system/database;
- Effective monitoring capabilities to ensure Best Execution:
- reflecting all of the relevant quantitative and qualitative metrics (price, cost, speed, likelihood of execution, settlement, size, and nature of the trade);
- based on adequate sample sizes;
- covering all relevant asset classes;
- Flexibility to adapt efficiently to your specific needs i.e. set up specific checks consistent with your Best Execution Policy and practices;
- On-going and regular monitoring for Best Execution (on-demand checks are also available);
- Ad-hoc investigations for Best Execution of specific orders/transactions;
- Flagging Best Execution failures including automatic notification alerts;
- Recording and logging capabilities of all monitoring checks for future examination;
- On-going updates/changes to adapt regulatory changes and new practices/checks followed by regulators;
- Technology Optimization;
- Program Management;
- Change Management;
- Web-based integrated dashboard provides a holistic view of Best Execution analysis;
- Comprehensive regulatory monitoring/reporting IT infrastructure resulting in long term cost efficiencies;
- Cost efficient integrated monitoring/reporting solutions provided under a single platform;
Solution includes:
- Setup – A team of specialists will provide guidance on extracting relevant data as needed;
- Dashboard access – Access to our Polaris dashboard;
- Systematic Best Execution Monitoring;
- Training – Best Execution monitoring training throughout the implementation process to ensure that key personnel understand the regulation and the process;
- Consulting level Support – Answer any queries regarding the system or any regulatory updates;
For more information about our services, please feel free to contact us or complete the form below.


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According to Qichacha, a business registration information reference website, the business license for LeTV Sports Culture Develop (Beijing) Co. has been revoked.
Revoking the business license of a company is a punitive administrative measure implemented by the Administration of Industry and Commerce on law-breaking business entities. Once the business license is revoked, the company should enter into the liquidation process. The enterprise legal person will cease to exist only after the liquidation has been completed , and the company has cancelled registration with the Administration of Industry and Commerce.
LeTV Sports are now involved in multiple arbitration and lawsuit cases and it is unclear how the revoking of their business license will affect these cases. LeTV Sports published an announcement on their website on May 15, revealing the ruling by the Beijing Arbitration Commission that LeEco need to pay their shareholder Qianhai Situo for share repurchase. The announcement also revealed that 14 shareholders, including Qianhai Situo, had launched arbitration requests against the company, and that the arbitration was still under way for the other 13 shareholders. Internal estimates by LeEco concluded that the maximum payment for the share repurchase could reach over RMB 11 billion.
Reference: The Beijing News
Proofread by Raymond Fitzpatrick

subset: commoncrawl


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Centre Esplai Hostel
Virtual tour
Take a 360º walk around Centre Esplai and discover its sights without even leaving your home. If you have VR glasses, put them on for a total immersion experience.
We're waiting for you!
Eco hostel
Did you know that Centre Esplai has BIOSPHERE sustainable tourism certification? We save water, recycle, produce green energy, use local foods, educate others about sustainability, etc.
A unique hostel
Natural and comfortable oasis
We have everything you need for an ecological, accessible, easy and unforgettable stay in Barcelona. Centre Esplai is perfect for families, school groups, sports clubs, conferences and anyone who wants to take care of the environment. Sound just like you, right?
These groups have stayed with us
The Spanish Suzuki Method Federation held our annual teaching meeting at Centre Esplai. The proximity to the airport really made our logistics easier, and the comfort and versatility of the spaces really suited the meetings. The family playroom was a hit that helped us with family balance.
Our organization, CAPS – Home to Home, has been using the Centre Esplai Hostel for 4 years. This is the best spot to carry out our sessions due to its proximity to the airport, spacious rooms, restaurant, parking, auditorium, etc. An unbeatable space for formal sessions and workshops, or carry out a session in the garden.
Last posts
Which birds spend the winter in the Llobregat Delta?
Not long ago on this blog we talked about the practice of Birdwatching. Do you remember what that is? Well, it has to do with the practice of observing and studying birds in a specific location. As you already know, our favorite place for birdwatching is right next to...
6 benefits of using LED lighting in the Hostel
Quan parlem d'una "vida ecològica", d'estalvi energètic i sostenibilitat, parlem dels principis bàsics amb els quals es regeix l'Alberg Centre Esplai! Es tracta d'un edifici completament sostenible, des del seu disseny i construcció fins a les tècniques d'estalvi i...
How does reusing grey water work in a hostel?
One of the most significant problems in the world scope is the availability of an essential resouce such as water: we currently know that more than 1,000 million people live in regions lacking this resource, and there are 3,500 million more that could be in the same...
Book now
We are Fundesplai
We are a non-profit organisation that has been working on behalf of education and happiness for children, equality, social inclusion, protecting the environment and developing the tertiary sector for over 45 years.
The Centre Esplai Hostel works with us on our educative, social and environmental tasks.


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January 03, 2009
Guest Review: Benefit's Mascara Gets Eli Bent out of shape
Has anyone flipped through the British Vogue's December issue? If you haven't, you should. It's very thick, very lovely and has a few good articles in there. I would have bought it if it wasn't for the AUD 20 price tag. Happily, my sister bought a copy so I am hijacking it when I visit her in a few days.
I ended up with the Australian Vogue instead. They are giving away free tubes of Benefit's "Get Bent" mascara with each copy. Reading material and makeup for AUD 7.95? How is a girl to resist?
On hindsight, I should have resisted.
"Get Bent" is Benefit's version of a push-up bra for eyelashes: it's supposed to lengthen, lift and add more oomph to eyelashes. The reason why this mascara is called "Bent" is because the pine cone-shaped brush is bent to allow better application to one's eyelashes.
I dislike this mascara so much; I am having trouble deciding where to begin.
Angled mascara brushes are supposed to make life easier for those of us with large rounded eyes. The "Get Bent" brush makes life a lot harder. Trying to get an even application is near impossible with the tiny bristles while the combination of a huge brush head with an angle makes the brush difficult to handle. I actually ended up getting mascara on my eyelids – something which has never happened before.
The mascara formula itself does a pretty good job of lengthening eyelashes and of holding a curl for a few hours. I could feel my lashes brushing against my glasses when I slipped my spectacles on. However, any attempt at Bambi eyes with "Get Bent" would be spoilt by excessive smudging and flaking around the eyes within an hour of application. The formula also clumps madly and the long lashes created by this mascara look spidery rather than au natural.
Luckily, "Get Bent" washes right off with some warm water and a bit of cleanser. Halloween passed too long ago for me to trot around looking like a zombie.
Verdict? Stay far away, girls. Unless you like going around looking like a ghost from a horror flick. (Kahani: Or like Cullen? *grins*)
6 comments:
- Jenn said...
Hahahahaha!! I laughed so hard at the pun!! Who would've thought of that!! hehehe!!
Yikes!! Smudgey mascaras are horrible!! I'm glad you got it for free!! If i were to pay for this crap i think i'll kick myself really hard!! :S
- 3 January 2009 at 12:57
- Syen said...
Kahani: *growls* The Cullens are picture perfect. THEIR lashes need no mascara.
- 3 January 2009 at 16:23
- Kahani said...
Jenn: Oh honey, you really should not encourage me like this...
Syen: And the mascara won't be on their lashes. It will be under their eyes. Making them look all undead and sleep-deprived.
- 3 January 2009 at 16:49
- AskMeWhats said...
Kahani :) LOL :) Maybe..i can "try" to make you use it still? Try to use this then top it with a waterproof mascara? And see if it still smudge? I have a CG Lash Blast that's NON waterproof and you know how those get in tropical countries like ours, I top it off with a waterproof mascara and it stays well..plus it's easy to remove at the end of the day :)
- 3 January 2009 at 21:39
- Kahani said...
Thanks for the tip Nikki - it's actually Elizabeth's mascara. But I'm sure she'll appreciate the tip =) I can see how a volumnising waterproof would pair well with a lenghtening and lifting formula.
- 3 January 2009 at 23:15
What a terrible pun.
Nikki, thanks for the tip. But the mascara makes my eyelashes terribly spidery though. =/
- 3 January 2009 at 23:37


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Lawn Embroidery Dress 2020 UnStitched (DRL-418)
Rs. 1,890
Heavy Full Embroidery Chiffon Suit (Unstitched) (CHI-207)
Rs. 3,190
Embroidered Chiffon Unstitched 3 Piece Suit (CHI-222) (Unstitched)
Rs. 2,490
Embroidered Black Lawn Dress with Chiffon Dupatta UnStitched (DRL-423)
Rs. 1,690
Pakistani Chiffon Suit Embroidered in Royal Blue (CHI-33)
Coming Soon
Rs. 2,590
Embroidered Lawn Dress (2pcs) (DRL-64)
Rs. 1,590
Embroidered Chiffon Suit with Jamawar Trouser (CHI-172)
Rs. 2,990
Embroidered Masoori Dress with Jamawar Trouser (CHI-155)
Rs. 2,850


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Where & When
City of Milan
147 Wabash St. Contact the Parks & Rec. office at anytime for a list of programs offered or stop by our new on line registration website. Office Hours: Monday-Friday 8 am – 4 p m..734-439-1549.
Milan Seniors for Healthy Living is a non-profit organization that provides services, activities, and programs for the mature residents in and around Milan. It is located at 45 Neckel Court, Milan, MI 48160. The phone number is (734) 508-6229. Please call this number to register for our programs or if you need additional information. Our Newsletter is also accessible via MSHL website: www.milanseniors.org. Check the website for more information and the many events available.
Your Spot Youth Program MILAN BAPTIST CHURCH 36 Tolan St. every Thursday evening, there are all kinds of fun activities available for Grades 6 through 12.
Ignite the Fire at Milan Free Methodist Church 950 Arkona Rd . Ignite for grades 7-8 meets Sunday from 5-6:30 p.m. The Fire for grades 9-12 meets Sunday from 6:30-8:30 p.m. 734-439-2414 7734 (7340 – for gr. 7-8 – meets Sunday evenings from 5:00 to 6.
Milan Area Chamber Web: www.milanchamber.org and Milan Seniors for Healthy Living at http://www.milanseniors.org/ have more info about Milan and Senior events
Caregivers Support Group At Senior Center (MSHL) – 3rd Mondays monthly from 1 pm FACILITATED BY LANCE SLATTON CSCM from Enriched Life Home Care Services In the midst of caring for a loved one, it is easy to wrestle with the weight of that role. While often rewarding, caregiving requires a tremendous amount of energy and strength. It is important to take some time for yourself to recharge. Join us as we share the challenges and the rewards of caregiving. The purpose of this group is to create a community of support for caregivers and their families in an open forum to share experiences and resources. FREE.
May 9
The Secretary of State Mobil Office will return to the Milan Public Library from 11 a.m. to 5 p.m.. The Mobile Branch Office is a full serviced Secretary of State branch office on wheels.
May 10
Paddock Rock (talent/staff) Show doors open 5:30 p.m., show starts at 6 p.m.-7:30 p.m.
May 10
ACE Hardware 13th Annual Ladies' Night Event 6-8 p.m.
May 11
FILL A BAG Milan Post Office & Aid in Milan
May 11
Milan Dairy Barn Customer Appreciation 3-7 p.m.
May 12
Mother's Day
May 17 & 18
Dance Xplosion 2019 Recital 7 p.m. at Milan High School
May 18
Chicken Dinner @ London United Methodist Church 5-7 p.m. London United Methodist Church 113128 Plank Road, Milan, Michigan Great Salad Bar, Oven-fried Chicken, Mashed Potatoes and Gravy,,Vegetable, Roll and Butter, Beverage and Homemade Dessert, $10 for adults, $5 for children 5-10years of age, children under 5 free. Take-outs are available :Call (734-439-2680) the Day of the Dinner.
May 19
Pancake Breakfast at the Milan Area Fire Department on Sunday May 19th at 10 am and will go to about 2 pm or until all pancakes have been eaten. David Box lives in Milan, and is raising funds for Make a Wish Foundation in Michigan. He is going on a 300 mile bike ride to raise money so children with terminal cancer can get various wishes granted through this organization. The Wish A Mile bike ride, will take place July 25th through the 28th. .
May 19
TCA Big Band Spring Concert 4-5:30 p.m. Tecumseh Center for the Arts
May 21
Washtenaw Community Concert Band A Celebration of 40 Years! Tue 7:30 PM · Washtenaw Community College – Morris Lawrence Building
May 27
Memorial Day 9 a.m. at Marble Park Cemetery Memorial Ceremony with Parade continuing to Veteran's Wall of Honor
May 30 -June 1
Milan 70th Annual Community Fair
May 30
Carnival Bingo 6:30-9 p.m. at Wilson Park
May 31
Milan Community Fair Fireworks
June 2
Milan High School Graduation 2 p.m.
June 2
London United Methodist Church 113128 Plank Road, Milan, Michigan Tess Clarkson and her husband Jack will be leading our worship service, in our Pastor's absence, on Sunday, June 2, 2019. The Clarkson's, who have been entertaining together for over 30 years, will present a large portion of our service delivering their brand of southern gospel and country music. You will enjoy and be uplifted by their message. We will celebrate their visit with a love offering during worship and a potluck dinner following worship. Worship begins at 11 AM. Come, bring a dish to pass, and join us during this special worship service and dinner.
June 14
Milan students last day of school
June 16
Father's Day
June 21 & 22
20th Annual Mayfly Festival Wolverine Park Dundee Friday 4 p.m.-midnight and Sat. 11 a.m.-midnight
June 22
Milan Community Rummage Sale MSHL is hosting a community rummage sale in Wilson Park on Saturday, June 22 from 9am-5pm. All residents of the 48160 can reserve a space, anyone can shop!
July 4
Independence Day
July 13
Lavender Harvest Festival 10 a.m. – 6 p.m. 12040 Plank Rd. Milan
August 24
ABATE Region 14 Suicide Prevention & Awareness Event @ American Legion 44 Wabash St. Milan with Rotary pancake breakfast, motorcycle run, speakers, displays, entertainment by Side Step, door prizes, raffle items and 50/50 drawing
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1Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43126 Parma, Italy.
2Department of Surgery, University of Parma, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43126 Parma, Italy.
Correspondence Address: Dr. Gabriele Missale, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43126 Parma, Italy. E-mail: email@example.com
This is an open access article licensed under the terms of Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original author is credited and the new creations are licensed under the identical terms.
Aim: Sorafenib efficacy and safety in advanced hepatocellular carcinoma (HCC) have been demonstrated in two randomized international clinical trials and in clinical practice studies. Because of poor survival advantage, to identify clinical and biological parameters remains an unmet clinical need.
Methods: Eighty-four patients treated with sorafenib were evaluated for response to therapy and prognostic factors possibly associated with survival.
Results: Median overall survival was 8.5 months. Median duration of therapy was 2.5 months with a median daily dose of 800 mg (IQR 600-800). Dose was adjusted in 52% of patients. Radiological response to therapy showed a significant impact on survival. Child-Pugh score and neoplastic invasion of the portal system were negatively associated with survival. Continuation of sorafenib even at lower dose was positively correlated with survival. The multivariate analysis identified vascular invasion as the only independent variable: median survival of 5.5 months for neoplastic portal vein thrombosis compared to 12 months in the remaining subjects.
Conclusion: A lower sorafenib daily dose is advantageous, even though the reason of this association cannot be explained at present. Neoplastic portal vein thrombosis is strongly associated with dismal survival. Alternative or complementary treatment approaches should be studied in order to improve outcome in this subgroup of patients.
Hepatocellular carcinoma, sorafenib, neoplastic portal vein thrombosis
Hepatocellular carcinoma (HCC) is a primary solid tumor of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. It is the third leading cause of cancer deaths worldwide, with over 570,000 people affected[1,2]. The incidence of HCC is higher in Asia and Africa, where the endemic high prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections strongly predisposes to the development of chronic liver disease and consequently HCC[3,4]. In developed countries there is the growing problem of cirrhosis developing in the setting of non-alcoholic fatty liver disease in patients with obesity, type 2 diabetes, dyslipidemia and hypertension[5-8]. Programs of surveillance with upper abdomen ultrasound examination and characterization of focal liver lesions with computed tomography (CT) scan or magnetic resonance imaging (MRI) increase the rate of early diagnosis and curative treatments such as surgical resection, liver transplantation and locoregional ablative treatments[9-13] with improved survival. In the advanced stage, Barcelona Clinic Liver Cancer (BCLC) stage C, systemic therapy with sorafenib[14] represents the first line treatment for these patients, while regorafenib is available for second line as well as anti-PD-1 that has been recently approved by the Food and Drug Administration for HCC.
Sorafenib is an oral multi-kinase inhibitor that acts both on tumor cells by inhibiting cytoplasmic cascades RAS-RAF and MEK-ERK, involved in cells proliferation, and also on endothelial cells by blocking plasmatic receptors implicated mainly in neo-angiogenesis (VEGFR and PDGFR)[15-19]. A correct patient management can increase drug tolerability and seems to improve significantly quality of life and survival[20-24]. The opportunity to continue treatment also in patients with radiological progressive disease or when tolerance is poor despite dose adaptation remains controversial[25,26]. However, in clinical practice, progression is not always a clear indication to stop sorafenib, especially if there isn't a second-line trial available and in patients with a good Performance Status (PS) with a reasonable life expectancy, an excellent drug tolerance and slow tumor progression. Sorafenib, compared to other target therapies, shows low frequency of radiological responses, but stable disease can be achieved frequently as shown in registration trials[27].
The aim of the present study was to evaluate prognostic relevance of clinical, epidemiological and tumor characteristics on survival. Reported results confirmed that dose reduction is associated with longer survival underlining relevance of drug management to increase tolerability. On the other hand, neoplastic portal vein thrombosis, a condition associated with fast liver decompensation and disease progression, was independently associated with poor clinical outcome.
This is an observational monocentric retrospective study conducted on 84 consecutive subjects starting sorafenib treatment at the Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma. Data were obtained from the analysis of medical charts and a dedicated database. Inclusion criteria were: radiological or histological diagnosis of HCC not amenable to surgical resection or locoregional treatment, BCLC stage C, PS < 2 according to the Eastern Cooperative Oncology Group system, measurable lesions in CT or MRI scans. Patients with an impaired liver function and a Child-Pugh score ≥ 10 were excluded. Eighty-four patients were considered, 63 males (75%) and 21 females (25%), with a median age of 73 years (range 32-81) [Table 1]. Of these patients, 45% had comorbidities: the most frequent was hypertension (29 subjects), followed by diabetes mellitus (16 subjects), previous ischemic vascular events like heart attacks and stroke (11 subjects) and chronic obstructive pulmonary disease (COPD, 9 subjects). Eight subjects had a history of tumors other than HCC [Table 1]. The etiology of chronic liver disease underlying HCC was HCV infection in 46 patients (54.5%), nonalcoholic steatohepatitis or alcohol in 21 patients (25%), HBV infection in 7 patients (8.5%), HBV-HCV confection in 3 patients, while in 7 patients (8.5%) the cause of liver disease was unknown [Table 1]. Most of subjects (91.5%) was on a Child-Pugh score A, seven were scored B7 [Table 1]. Majority of patients (82%) was previously treated: 72.5% underwent loco-regional therapies, 33% surgical resection and 18% both [Table 1]. Regarding the anatomical characteristics of HCC, it appeared multifocal in 96.5% of cases and was interested in only one lobe of the liver in 77.5% of cases, most frequently the right [Table 2]. In 47 patients (56%) HCC showed signs of neoplastic vascular invasion and 20 subjects (24%) presented both vascular invasion and extrahepatic spread [Table 2]. Treatment was stopped at radiological evaluation at 8 weeks of treatment in case of disease progression.
Clinical and epidemiological characteristics of patient population at baseline
|63 (74%)
|21 (26%)
|Age (median years, IQR)
|73 (67-75)
|BMI (median, IQR)
|25 (23-28)
|Comorbidities (yes/no)
|39 (46.5%)/45 (53.5%)
|Diabetes mellitus
|Cardiovascular events
|Other tumours
|Kidney disease
|46/84 (54.5%)
|3/84 (3.5%)
|7/84 (8.5%)
|Alcohol and/or dysmetabolic
|21/84 (25%)
|Other or unknown
|7/84 (8.5%)
|Child-Pugh score
|21/84 (25%)
|56/84 (66.5%)
|7/84 (8.5%)
|Previous treatments (yes/no)
|69 (82%)/15 (18%)
|Loco-regional treatments
|Resection + loco-regional treatments
Anatomical and functional characteristics of hepatocellular carcinoma
|Location of tumour
|65/84 (77.5%)
|19/84 (22.5%)
|Extrahepatic spread
|52/84 (62%)
|32/84 (38%)
|Macroscopic vascular invasion
|37/84 (44%)
|47/84 (56%)
|Metastasis and macroscopic vascular invasion
|Both present
|20/84 (24%)
|Both absent
|27/84 (32%)
|Tumour marker at the beginning of therapy
|Alpha-fetoprotein (median ng/mL)
|130.5 (range 1-65,671)
The study was approved by the local ethical committee [Comitato Etico Indipendente (IRB/IEC) of the Azienda Ospedaliero-Universitaria of Parma, Italy].
Sorafenib was administered at a dose of 400 mg bid continuously, equivalent to a total daily dose of 800 mg, without food or with a low or moderate fatty meal. Therapy was continuous, but by convention was codified in cycles of 28 days. Patients had to measure their blood pressure at least twice daily and use skin lotions to prevent or reduce any hand-foot syndrome manifestation. Every 4 weeks a revaluation of treatment was planned through a detailed physical examination of patients, the correction of possible adverse effects (diarrhea, skin rash, high blood pressure, edema), the evaluation of blood tests examinations such as liver function tests (transaminases, albumin, bilirubin), renal function (creatinine, urea, electrolytes), coagulation parameters (prothrombin time), lipase, creatine-phosphokinase and the alpha-fetoprotein dosage. It was allowed to reduce sorafenib dose to limit adverse effects of treatment. A thorax-abdomen CT scan with contrast was scheduled at 8 weeks of treatment. The instrumental response to treatment was evaluated according to Modified Response Evaluation Criteria in Solid Tumors criteria[11,12]: complete response (CR) was defined as the disappearance of intra-tumoral arterial enhancement in all target lesions, partial response (PR) as a reduction > 30% of the sum of the diameters of the vital areas in the parameter lesions and progressive disease (PD) as an increase of > 20% of the sum of the diameters of the vital areas in the parameter lesions, compared to the baseline size. Stable disease (SD) included all the other cases not classified as PR or PD. In patients classified as not applied, therapy was interrupted before 8 weeks because of liver failure, adverse events or poor performance status.
Toxicity was evaluated according to National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0[20] every 4 weeks. According to the grade of the event, a dose reduction or suspension of the treatment was planned. For grade 1 adverse events it was advised to institute supportive measures and continue sorafenib treatment; at first appearance of grade 2 adverse events it was suggested to establish support measures and reduce sorafenib at 400 mg/day for 28 days: if toxicity regressed to grade 1, it was indicated to re-increase the dose at 400 mg twice daily, otherwise it was recommended to discontinue sorafenib for at least 7 days then 400 mg/day, finally the full dose. At the appearance of the second or third potential grade 2 toxicity, sorafenib was permanently administered at the reduced dose of 400 mg/day. In case of the fourth appearance of grade 2 adverse event it was considered the definitive suspension of treatment. At the occurrence of grade 3 toxicity, sorafenib was interrupted for at least 7 days or until the decrease to grade 0-1, then prescribed at a low dose (400 mg/day) and further increased to 400 mg twice a day. At the second appearance of grade 3 adverse event, the conduct was the same, but at the time of resumption sorafenib was definitely prescribed a low dose (400 mg/day). In some cases, it was performed a treatment with lower doses than indicated above, up to a minimum of 200 mg/day.
Survival curves are expressed by Kaplan-Meier curves and compared with log-rank test. Cox proportional hazards model was used for multivariate analysis of survival. The variables associated with survival showing a P value < 0.1 in the univariate analysis were included in the multivariate analysis model, except response rate that was not available for all patients. Prism (Graph Pad) and StatPlus (AnalystSoft Inc.) were used to perform the statistical analysis. The comparison between mean values was performed with Student t test for unpaired data. Statistical significance was considered for values P < 0.05.
Results on response rate, treatment duration, sorafenib dose and side effects are reported in Table 3: PR was achieved in 5 patients (6%), SD in 32% and PD in 31% of patients. None of patients achieved a CR. Treatment was discontinued for adverse events or clinical worsening before radiological evaluation in 26 patients (31%). Median treatment duration was 2.5 months. Forty patients (48%) received full sorafenib dose (800 mg/day) during all the treatment, while 44 subjects (52%) reduced sorafenib dose. Median daily dose was 800 mg. Thirty-seven percent of patients received a median dose of 800 mg, while the remaining (63%) a minor dose (range 200-600 mg) because of adverse events. Dose reductions ranged between 5% and 90% of the time on treatment. Most of patients (92.5%) developed adverse events: gastro-intestinal symptoms, asthenia, rash and skin peeling and high blood pressure; the most common adverse event was severe weight loss associated with asthenia and diarrhea. Finally, 20 patients after sorafenib discontinuation received other treatments: percutaneous ablative treatments (2 patients) or other systemic treatments such as capecitabine or tivantinib (6 patients).
Dose, duration and response of treatment
|Treatment duration (median months)
|Response rate
|5/84 (6%)
|27/84 (32%)
|26/84 (31%)
|26/84 (31%)
|Median daily dose mg (IQR)
|800 (600-800)
|Patients treated with median dose of 800 mg
|53/84 (63%)
|Patients treated with median dose < 800 mg
|31/84 (37%)
|Dose reduction
|44/84 (52%)
|40/84 (48%)
|Adverse events (yes/no)
|77 (91.5%)/7 (8.5%)
|72/77 (93.5%)
|Gastro-intestinal symptoms
|63/77 (82%)
|Rash, peeling, itchy (general)
|48/77 (62%)
|36/77 (47%)
|27/77 (35%)
|21/77 (27%)
|15/77 (19.5%)
|Cardiovascular events
|0/77 (0%)
|Reason of treatment suspension
|Progressive disease
|25/84 (30%)
|Adverse events
|23/84 (27%)
|Liver failure
|22/84 (26%)
|Other reasons
|7/84 (9%)
Median overall survival was 8.5 months [Figure 1A]. The epidemiological and clinical parameters shown in Table 1 were assessed as factors that could have an effect on survival. Only Child-Pugh score (A vs. B; P = 0.0289) showed an impact on survival, while the remaining epidemiological and clinical characteristics did not show significant differences. History of previous treatment for HCC was a positive factor, however not achieving statistical significance [Table 4], in particular also considering independently locoregional treatments, that represented the most frequent treatment, there was no significant impact on survival (not shown). Eight patients with history of different tumors showed comparable survival to the remaining subjects (not shown).
Univariate and multivariate analysis of variables potentially related with survival
|Median age (< 73 vs. > 73 years)
|0.98 (0.60-1.59)
|Gender (male vs. female)
|0.98 (0.55-1.75)
|Comorbidities (yes vs. no)
|0.72 (0.44-1.15)
|Etiology (only HCV vs. no HCV)
|1.08 (0.64-1.82)
|Child-Pugh score (A vs. B)
|0.44 (0.09-0.88)
|0.48 (0.20-1.13)
|AFP levels (< 130.5 vs. > 130.5 ng)
|0.78 (0.47-1.25)
|Response rate (PD vs. PR + SD)
|2.08 (1.10-3.92)
|Localitation (mono vs. bilobar)
|1.54 (0.84-2.66)
|Extrahepatic spread (yes vs. no)
|1.20 (0.75-2.00)
|Macrovascular invasion (yes vs. no)
|1.73 (1.14-3.14)
|1.84 (1.11-3.05)
|Previous therapies (yes vs. no)
|0.59 (0.25-1.04)
|0.81 (0.42-1.55)
|Dose reduction (yes vs. no)
|0.52 (0.29-0.79)
|0.73 (0.31-1.66)
|Median daily dose (< 800 vs. 800 mg)
|0.60 (0.37-0.98)
|0.73 (0.37-1.42)
Figure 1. Overall survival (OS) of the whole patient population and survival according to risk factors. (A) Median OS for sorafenib treated patients was 8.5 months; (B) presence of macroscopic neoplastic vascular invasion of the portal venous system, present in 56% of subjects, was a strong negative predictor on survival, with a median OS of 5.5 vs. 12 months observed in patients without neoplastic thrombosis; (C) a duration of sorafenib treatment beyond median time of 2.5 months positively influenced outcome (median OS 11 vs. 3.5 months); (D) analysis of radiological response rate at 8 weeks of treatment showed a significant impact on survival: median OS was 12.5 months in subjects with stable disease or partial response and 9.5 months in progressive disease patients; (E) dose reduction showed a benefit on survival (median OS 11 vs. 5 months); (F) sorafenib daily dose below median (800 mg) was associated with better survival (median OS 10.5 vs. 6 months)
Tumor parameters [Table 2] were evaluated as factors potentially influencing survival. Unexpectedly, alpha-fetoprotein levels, multifocal tumor extended to both lobes as well as extrahepatic spread didn't influence survival significantly. Macroscopic vascular invasion was found to be a strong predictor for survival (P = 0.0141) [Figure 1B], while the association of metastasis and vascular invasion did not worsen patient outcome.
All data related to therapy reported in Table 3 were analyzed as parameters that could influence clinical outcome. As expected, longer duration of therapy (beyond median time of treatment) was positively associated with survival (P < 0.0001) [Figure 1C], even though this may not represent an effect of treatment, since other factors like progressive disease or adverse events, could have influenced time on treatment. Response rate showed a significant impact on survival (P = 0.0237) [Figure 1D], with median survival of 12.5 months in patients with SD or PR compared to 9.5 months for patients with PD. Dose reduction was a favorable parameter (P = 0.004) as well as drug regimen below median daily dose (P = 0.04) [Figure 1E and F].
Sorafenib appeared well-tolerated as in previous studies and registration trials, however adverse events were reported, also in this study. Overall incidence of adverse effects was 91.5% of this cohort [Table 3]. Asthenia, fatigue and gastro-intestinal symptoms (mainly moderate to serious diarrhea) were the most common adverse events that required patient hospitalization in some cases; rash, itch, hypertension, hand-foot skin reaction (HFSR), alopecia and bleeding were reported in some cases. Cardiovascular events linked to sorafenib treatment were not observed.
All studied parameters were evaluated for their impact on survival. As shown in Table 4 by univariate analysis: Child-Pugh score, neoplastic vascular invasion, dose reduction and median daily dose showed a significant effect. In particular, Child A, absence of vascular invasion, dose reduction and daily dose lower than median were associated with improved survival. Multivariate analysis showed that neoplastic vascular invasion was the only independent condition correlated with a worse outcome [P = 0.0166; hazard ratio (HR) = 1.846, 95% confidence interval (CI) = 1.118-3.050].
The aim of this study was to analyze the role of epidemiological, clinical, tumor parameters and treatment dose on clinical outcome in a cohort of 84 patients from a single clinical center. Outcome was measured as overall survival. Sorafenib effectiveness was confirmed by response rate, that was significantly associated with survival (P = 0.0237). In particular, PR was achieved in 5 patients (6%), while SD in 27 patients (32%).
Metastasis were negatively associated with rate response while there was no significant association with portal thrombosis and intrahepatic tumor burden. Our patients were all in BCLC stage C with majority (91.5%) of subjects with compensated liver disease (Child-A) and the remaining patients with Child-B cirrhosis. If compared to previous studies, our patient cohort was characterized by a more advanced tumor stage. In fact, the 2 registration trials included 18%[28] and 5%[14] of patients with intermediate HCC stage (BCLC-B), similarly to real-life studies including 19-25% of patients that could be classified in the intermediate stage while all our patients were in BCLC-C stage. Even if stage was more advanced, median survival was 8.5 months, comparable to what observed in registration trials[14,28], ranging between 6.5 and 10.7 months and real-life studies[28,29]. Median time on treatment was 2.5 months that is indeed less than what reported in other studies ranging between 3.75 and 5.1 months[14,28-30]. This may be explained by the more advanced tumor stage of these patients characterized by early disease progression in many cases leading to early discontinuation.
Neoplastic portal thrombosis was present in 56% of the cases while it ranged between 22% and 39% in previous studies[14,28-30]. Major causes of early stop of treatment were premature death, hepatic failure, other complications as systemic infections and sorafenib intolerance.
Then we evaluated parameters significantly associated with longer overall survival. Child-Pugh score A, absence of macroscopic vascular invasion and reduced sorafenib daily dose (below median value) were identified by univariate analysis while only absence of neoplastic portal vein thrombosis was independently associated with survival by Cox regression analysis. Multivariate analysis, showed that macroscopic vascular invasion almost doubled the risk of death (HR = 1.846), similarly to what previously reported[28,29] (HR = 1.7), thus confirming that the presence of portal neoplastic thrombosis is a very negative prognostic factor on survival. Indeed, this condition severely impacts on the natural history of the disease, characterized by an aggressive disease course, because of fast spread of cancer cells, worsening of portal hypertension and liver function and poorer tolerance to treatment. As evidence of this, majority of patients (71%) stopping treatment before radiologic evaluation presented this complication. Neoplastic macrovascular invasion was associated with a survival expectancy less than half, suggesting the usefulness to investigate alternative treatments like combination of different therapies modalities such as external radiotherapy or selective internal radiation therapy[24]. Whether best supportive care may represent the best medical option may not be concluded on the base of our findings however it could be considered in selected cases.
Interestingly, sorafenib dose reduction and median daily dose less than 800 mg were positively associated with survival, in fact patients that reduced dose during treatment showed a median survival of 11 months compared to 5 months of the remaining patients. Similarly, it has been reported a survival of 21.6 months compared to 9.6 months for patients treated for more than 70% of the time at half dose[29]. Therefore, a lower dose may be advantageous, enabling a more prolonged treatment, with no reduction of therapeutic effect. In other studies[30,31], starting dose, was analyzed as a variable that could influence management and efficacy of sorafenib showing longer time on treatment and better survival for patients starting with full dose. However, in this study[31] median daily dose was not reported and is not clear if dose reductions allowed longer time on treatment and better outcome.
Treatment adverse events were not significantly different compared to previous reports, registering at least one adverse effects in 91.5% of our patients. The most common effects didn't differ to what previously reported[14,28-30], represented by asthenia, gastro-intestinal symptoms, in particular moderate or severe diarrhea, hypertension and dermatological lesions as systemic rash or HFSR.
In conclusion, portal neoplastic thrombosis is the most important prognostic factor being associated with a rapid clinical deterioration leading to death. Finally, we confirm the importance of clinical management for individualized treatment dose in order to provide longer treatment periods, that seems to be crucial to improve survival of our patients.
Concept and design: G. Missale, C. Schianchi
Data acquisition: M. Lecchini, E. Biasini
Data analysis: M. Lecchini, A. Olivani, E. Biasini, R. Dalla Valle, G. Missale
Statistical analysis: A. Olivani, G. Missale
Literature search and manuscript preparation: M. Lecchini
Manuscript editing: A. Olivani, C. Ferrari, G. Missale, C. Schianchi
Manuscript review: C. Ferrari, G. Missale, C. SchianchiFinancial support and sponsorship
This work was supported by FIRB grant from the Italian Ministry of the University and Research, Protocol RBAP10TPXK.Conflicts of interest
There are no conflicts of interest.Patient consent
Consent was obtained from patients still alive at the time of data collection and analysis.Ethics approval
The study was approved by the local ethical committee (Comitato Etico Indipendente (IRB/IEC) of the Azienda Ospedaliero-Universitaria of Parma, Italy).Copyright
© The Author(s) 2017.
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We begin with meticulously sourced beans, choosing only those whose flavors and profiles can stand up to decaffeination. We make that process as gentle as possible with the Swiss Water Decaf process.
Swiss Water decaf process was created in the 1930s, and it is the only certifiably organic way to remove caffeine. This process instead relies on hot water, osmosis, and an activated charcoal filter.The result is a decaffeinated bean that still carries its own flavors and aromas; our blend brings a lightly sweet but full-bodied experience, and makes an outstanding espresso or cup of drip.
We source decaf coffees from Brazil or Colombia.


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Ukraine reduced electrical energy export by 14%
18:28, 19 July 2006Ukraine
417 0
In first half-year of 2006
During the first half of the year 2006, Ukraine exported 4 billion 665.2 million KW/h of electrical energy, which is by 747.7 million KW/h, or 13.8% less than during the same period of the last year. UNIAN was told about this at the Fuel-Energy Ministry of Ukraine.
According to the information of the Ministry, in June of 2006, Ukraine exported 843.9 million KW/h of electrical energy, which is by 106.2 million KW/h, or by 11.2% less than during June of the year 2005.
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The Vespa GTS 150 renews itself, by adopting the very modern and technologically advanced i-get engine in its most advanced version, with liquid cooling, electronic fuel injection, 4 valve timing, and, for the first time on a Vespa, the "Start and Stop" system.
The Vespa GTS has always evolved along the path of tradition, striking a magic balance between tradition and modernity in the lines of the body, made strictly of steel. The Vespa GTS still preserves the characteristic and distinct traits of the large-body Vespa, but it includes numerous and important stylistic updates. The Vespa GTS has an ornament of modern design on the front fender, front and rear turning lights characterised by transparent parts and by a rear optical group enriched by a chrome-plated frame, which repeats the motif of the crest on the front fender. The cover of the centre tunnel if the foot board is ornamented by the Vespa logo.
The perfect ergonomics and the natural seat position have always contributed to making every Vespa comfortable, pleasant to ride and accessible to all. The saddle of the Vespa GTS 150 provides superior comfort, thanks to the specific padding and new upholstery. The under-saddle space makes optimum use of the available room and can accommodate two Vespa demi-jet helmets and more. The drawer in the leg shield back plate contributes to increase the load capacity of the new Vespa GTS. It is ideal to keep at hand smaller items such as glasses, documents, and mobile phone. The handy bag hook, in the upper part of the leg shield back plate also helps.SUMMER SPECIAL - $6500.00 plus orc. Beat Auckland trafffic and parking with this excellent value new Vespa!
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Lindsay & David added to Favorites!
Click here to access your Favorite Families or select "My Favorite Families" from the "Choose A Family" menu.
Lindsay & David removed from Favorites!
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dear expectant mother
Thank you for considering us to be the parents of your precious baby. We cannot begin to imagine how difficult this decision must be for you, but we can promise to return your act of courage and selflessness by treasuring and loving your baby unconditionally. We are forever grateful.
Adopting a baby is something we have always wished and hoped for. When we imagined our dream family, adoption was at the forefront. It would be the greatest gift, and we would never take it for granted. We are so looking forward to creating a lifetime of memories together with your child, pushing him or her on the swings in our back yard while singing songs, and swimming and jumping through sprinklers together in the summer. We will read stories before bed and have David's funny-face pancakes on Saturday mornings at the kitchen table.
We will always be open in discussing our adoption journey, especially when it comes to you, the hero of this story. We will raise your baby with love and encouragement, and we will model how to be confident and caring. We will teach him or her to be adventurous and to follow their dreams, however big they may be. Please know that your baby will be eternally adored and supported by a very loving family.
About Us
We met in North Carolina. Lindsay was a teacher there, and David was visiting family during a weekend off from the Navy. Since marrying in 2010, we have lived in four states and have had two children. Elle was born in 2012, and Teddy was born in 2015. We settled in Florida to be closer to family and operate our business, a chain of swim schools. David is the owner and general manager. He loves sports, spending time outdoors, and makes the greatest breakfasts. David is outgoing, honest, and dedicated to his family. Lindsay is a stay-at-home parent. When possible, Lindsay helps with the swim schools. She loves to cook, read, and watch movies. She is nurturing, dependable, and kind. We are both passionate about teaching children to swim and about water safety. Our children are our greatest sources of joy and entertainment; each day with them is an adventure.
Our Home & Pets
Our home is the perfect place to learn, grow, love, and play. It is tucked away on a quiet, tree-lined street. We have a back yard filled with children's games and activities. Inside, there's a playroom with toys for all. You'll always find us playing games, going for bike or scooter rides, drawing with chalk, or playing with bubbles. Our two dogs are also never far. They like to be in on the action and live for food that falls to the floor. Our neighborhood is filled with friendly faces and children of all ages. The neighborhood schools are the best in the state.
Our Extended Family
We have a very large family and love spending time with them any chance we get. David comes from a family of four. He has one brother and two sisters. Lindsay has one sister, whom she is very close with. She also has a stepsister, two stepbrothers, and four half-siblings.
Our families are thrilled they can join us on our adoption adventure, and they have been nothing but supportive. It's been really fun sharing this journey together. Lindsay's parents live less than a mile and a half away. They have a pool that is always warm and ready for swimming, and it's a quick drive or bike ride to sandy beaches. David's parents own a vacation home in South Carolina, where we spend one week each summer with the entire extended family. It's the best place to catch fish off the dock or relax in a hammock in the shade. We try to alternate holidays with our families so we're able to see both sides during the holiday season. When visitors come to us, it is always fun to take them to Disney World, the beach, Busch Gardens, or the botanical gardens.
What Led Us To Adoption
It has always been our dream to grow our family through adoption. Even while dating, we envisioned a large, happy family, and adoption was part of that picture. We have moved several times over the past twelve years and wanted to feel more settled and secure in a city before beginning the exciting process of adopting a baby. We're ready! Together, we have created a safe, loving, and joyful home. We cannot wait to welcome another child into our lives and our hearts.
Fun Facts
About Lindsay
|Stay-at-home parent
|Bachelor's in Elementary Education and Early Childhood Development
|Favorite Food
|Favorite Hobby
|Trying out new recipes
|Favorite Holiday
|Favorite Music Group
|Any Motown music
|Favorite Book
|Favorite Activity
|Going on a picnic in the park
|Favorite Tradition
|Watching fireworks on the Fourth of July
|Dream Vacation
About David
|Small business owner
|Bachelor's in Energy and Sustainability Policy
|Favorite Food
|Favorite Hobby
|Favorite Holiday
|Favorite Music Group
|Pop music
|Favorite Book
|Harry Potter
|Favorite Activity
|Cooking out
|Favorite Tradition
|Christmas tree shopping
|Dream Vacation
Contact Lindsay & David
Choose a Family for
Your Baby With Confidence
As you browse our list of hopeful adoptive parents, you can feel confident in knowing that all of the adoptive families working with Angel Adoption are prepared to offer your baby a safe, stable, and loving environment along with a wealth of opportunities for a happy and fulfilling life.
Each adoptive parent has been thoroughly evaluated through a home study course conducted by a licensed agency. A completed home study means the family is emotionally, physically, and financially ready to adopt a baby.
The home study process includes assessments of each parent's character, marital stability, financial situation, lifestyle, and medical history. The agency also runs background checks to verify there is no record of criminal activity or child abuse. In addition, a social worker will inspect the family's home to ensure it is a safe environment for a child.
Furthermore, Angel Adoption requires each family to be educated on adopting and parenting. After a baby has been placed with the adoptive family, a social worker will continue to monitor and supervise the family. We go to great lengths to make sure all the families you have to choose from are going to be excellent parents for your baby!
Not sure how to start? See our How to Choose an Adoptive Family resource page.
If you need more help, you're always welcome to contact us any time!


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3324 Peachtree Rd. NE., Suite C.
Phone: 770-484-7888
POTENTIAL COMMERCIAL!! In Hwy 92 Overlay - NO rezoning necessary for PERMITTED use! 604 Lovejoy is being sold with 602 Lovejoy Lane (adjacent property). Both parcels are within walking distance to Target, Old Navy, Discount Tire, Kohls, Petsmart, etc across the street. High traffic count at 33,500 on SR92 per day. Traffic light at Lovejoy Ln. & SR92. Lovejoy Ln connects to Bascomb Carmel Rd & connects to Bells Ferry Road. 1/2 Mile to I-575. All utilities. The value here is in the LAND - no value placed on the houses. DO NOT DISTURB residents living in the property.
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Listing information last updated on June 3rd, 2020 at 9:02pm EDT.


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It's no secret that people enjoy adult entertainment of all kinds. When people in the adult industry look for marketing news, information and contacts, many go straight to the source by visiting XBIZ.com. Now, XBIZ is taking notice of the legal weed industry and helping Weed Store Reviews to shine a bright light on the rapid evolution of this growing grassroots movement toward national legalization.
XBIZ is a brand built on more than a decade of experience in the trenches, reporting on the need for open and unfiltered access to legal content of all kinds online for a mature adult audience. If you have an interest in the way the nanny-state is continuing to roll back your privacy rights, are looking for a news source that publishes real, genuine, legal and B2B information you can put into action – or if you just want to see whats up in the porn business lately, there are worse ways to spend an afternoon than reading XBIZ with your favorite vaporizer in hand. It's news that is important… and entertaining.
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Interns Insight: 10 Things you need to know before developing a website
You need to identify the target audience for your website. This will be essential for branding and helping you to fulfil the goal behind the website. If you are trying to educate young people for example, young people must be able to actively engage with the content on your website. The branding must be attractive to young people. On the other hand if you are trying to sell a specific produce to a targeted population demographic, your website must be targeted towards this demographic.
Planning is ABSOLUTELY ESSENTIAL. You MUST have a clear business plan and your website must be part of this plan. By identifying your business goals, target audience, strategies and competitors you can easily plan how you want your website to look. Before one line of code for your website is written, you have to have a clear picture in your head how you want it to look.
Whatever the purpose of your business, you will always have competitors. These may even appear whilst you are developing your website. It is essential that you do not rush your website development and produce a haphazard site. Focus on outdoing a competitor. Analyse your unique selling points over your competitors and target your website towards these. Put your business personality into the website. A clear brand identity will make you easily identifiable and put your competitors in the shade.
One of the pitfalls often seen in website development occurs because you have not efficiently communicated to your website designer what you want them to do for you. Website development is an expensive process. Have in writing what you want the developer to do so if this is not done you have evidence to ensure errors are corrected and your initial vision is achieved. Before the designer starts establish what domain name you want and online service you want your website in (Weebly, Yola, WordPress, Odoo, Basekit website builders for example). Once a developer has started working on one website builder hosting service, it can be very expensive and time consuming to change this. Do your research on which service would suit your business the best.
Now everyone gossips on about SEO, but what is it? Basically, this is what decides how far down the list you are on a Google search. For the success of your business, it is essential you are quite high up this list. Google has certain algorithms which establish this. Recent SEO changes have targeted "spam" (too- sales orientated) websites and non-mobile friendly websites. If your website has bad SEO, the chances of anyone finding it is very low so it is essential you stay on top of this even once the site is up and running.
Do not give away your whole business plan on your website. The less words you use the better. If you have a great idea, it might be a good idea to look into intellectual property law, non-disclosure agreements and patents with your web developers and your idea. The more you give away for free on your website, the easier it is for someone to copy this and the more your competitors have over you.
Your website must continuously evolve to increase traction to the site. A good onside social media campaign tied to the site will continuously bring potential leads to the site and so it is essential that your website appeals to these leads. You must also have someone on team with knowledge of how to fix any issues with the site. A slow or badly coded website looks very unprofessional. All links, videos and purchasing processes MUST work.
A good analytics programme allied to your website, such as Google analytics, will easily allow you to see how effective your website is. Monitor every page for visitors, clicks and purchases and see what changes need to be made to make your website more effective.
Send people links to your website and ask what they think needs changing. Feedback prevents failure. Do not be offended. Take criticism as advice.
Be proud of your business. The more optimistic and energetic the website, the more attractive it will appear to users.


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Laptop Gaming Club
CPU: Intel Core i7-6700 Graphics: Nvidia GeForce GTX 1080 RAM: Not included; as much as 32GB DDR4 Storage: Not included Connectivity: 802.11ac; Twin Gigabit Ethernet ports; Bluetooth 4.zero Energy supply: 2 x AC Adapter (DC 19.5V/180W) Ports: four x USB three.0, 1 x USB three.1 Kind-A, 1 USB three.1 Sort-C, 1x microphone jack, 1x headphone jack, 2 x DisplayPort 1.three, 3 x HDMI 2.zero, SD card reader. The Dell XPS Tower Particular Version is a reminder of just how convenient and reasonably priced it may be to skip the laborious meeting course of and simply buy your gaming LAPTOP from a distinguished and nicely-liked producer. These playing cards, powered by technologies from longtime rivals AMD or Nvidia, make extra superior graphical particulars and improved efficiency potential. Take up your sword, race across distant lands, journey to unknown locations, and design new worlds, all from the consolation of your property. In the event you're searching for an attractive and unique LAN-friendly gaming PC that can handle something from 4K gaming to VR, the Asteroid is an out-of-this-world machine with a price ticket that may deliver you again right down to earth. Earlier than you proceed to optimize your LAPTOP, think about benchmarking Learn how to Benchmark Your CPU and GPU Like a Pro How you can Benchmark Your CPU and GPU Like a Pro Benchmarking permits customers to gauge hardware efficiency, troubleshoot points, and examine system setups.]]>


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Students will learn about the African American inventor Jan Earnst Matzeliger as they make art using the impressions made by the soles of their shoes.
What You Need:
- 9×12 white drawing paper
- crayons
- scissors
- large sheet of craft paper
- oil pastels
- tempera paint
- markers
- sneakers
- glue
- sequins or other found objects
What You Do:
Research the African-American inventor, Jan Matzeliger – who invented the shoe-lasting machine. The "shoe-lasting" machine would automatically stitch the leather of the shoe to the sole. This invention was very important because it lowered the cost to both the manufacturer and the customer.
Begin with a short discussion on texture. (what is texture?)
Students will make a texture rubbing of the bottom of their shoe.
Students will paint the bottom of their shoes with paint and make a print.
Then, students can add details (using markers) to the rubbing or print including eyes, arms, legs, teeth, horns, etc.
Further embellishments can be added with glue and found objects (like sequins)
- Divide the class into at least two groups.
- Students can create an environment for their monsters.
- Glue monsters to large piece of craft paper.
- Use oil pastels to complete the monsters' world. (Regular crayons can be substituted)
- Jan Matzeliger
- Jan Ernst Matzeliger


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Pregnant Woman Awesomely Tells Anti-Abortion Protesters Everything You've Always Wanted To Tell Anti-Choicers — VIDEO
This woman is seriously my new hero, and probably soon to be yours too. Outside an abortion clinic in London, this pregnant woman absolutely destroyed some anti-abortion protestors with an impassioned and eloquent rant on women's rights. It's the speech you've always wanted to make whenever you've seen someone being a jerk, but only ever dreamed up after the fact. And it spews out of her so effortlessly that it doesn't even need editing to make its point more forcefully. I am honestly floored by this good samaritan.
The incident starts with journalist Sunny Hundal who approached anti-abortion activists outside the Southwark Clinic (run by the British Pregnancy Advice Service and hosted by Blackfriars Medical Practice) and challenged one protester's use of a camera to film women going into the clinic. The pregnant lady hangs back at first, but soon kicks off in the best way possible at the 1:13 minute mark—and it's glorious. She accuses the protestors of uninformed judgement, telling them she works at Kids Company UK with vulnerable children (the group is rumored to have received many donations since this video went viral), and that the protestors don't know what drives women to abortion. She also chastises one of the protestors who had previously had an abortion, telling her that she's responsible for her own decisions and can't force other women to pay for them. It's seriously everything you've ever wanted to say to an anti-abortion group, and you can watch it in all its wonder here:
The protestors are from a group called Abort67, and the main aim of their activity is to "shame" women into not having abortions ("shame" being the word the group itself has chosen to describe its actions). Abort67 provided the following statement to Buzzfeed:
"We are outside abortion clinics, not to protest, but to expose abortion. Every time we hold up an abortion victim photograph, abortion protests itself. Our banners make it absolutely plain that abortion is an act of violence that kills a defenceless human person. Exposing the truth of what BPAS will do to these women's children can't be wrong. What is wrong is for BPAS to systematically deceive women. Our work informs and empowers women whereas the suggestion that women are unable to handle the facts infantilises them. Time and again we have met women who weren't told the truth about abortion and now regret their decision. We are concerned about the plight of the women who will elect abortion if the abortion pictures are concealed but reject abortion if the abortion pictures are displayed. For these women, there can be no true informed consent without abortion pictures."
"The YouTube video by Sunny Hundal which reveals the gentle nature by which we hold our displays serves to emphasise that abortion is indefensible. Pro-aborts like Sunny can't defend killing small human beings so he tries (in vain) to shame our volunteers for trying to defend the unborn child. In the same way that William Wilberforce and Thomas Clarkson were subject to false allegations and attacks by Slave Trade supporters, abortion supporters mischaracterise us and our conduct. Suggesting that we are harassing and intimidating women when there is no actual harassment or intimidation occurring is misogynistic. It suggests that women are inherently too weak to be fully informed about abortion. If harassment were occurring, the police who keenly observe us at our invitation, would arrest us. Sunny seems to miss the irony of filming us outside the clinic whilst he vilifies us for filming ourselves outside a clinic."
Journalist Sunny Hundal, who filmed the video, also reached out to Buzzfeed with his own statement:
"In the UK we assume abortion rights are safe. But the aim of groups like Abort67 and some MPs is to change the debate so they can chip away at these rights... I was just in awe of [the pregnant woman in the video], and was pleased others felt the same way... [Abort67] they shouldn't be intimidating women as they are now. This is why we need exclusion zones, like BPAS are calling for."
The pregnant lady is as yet unidentified. Hence why we keep calling her "the pregnant lady". I just want her to know though: Pregnant lady, you're all our hero today.
Image: YouTube


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Rare Opportunity to acquire a Development site in the Heart of Commercial Drive. Steps away from the drive, and walking distance to the sky train station and Trout Lake. Build an apartment with 1.45 FSR or build a rental housing and increase your FSR to 2.6. The Drive is one of the most authentic and culturally rich neighborhoods in East Van. The Drive includes Little Italy which is 8 blocks of over 60 years of Italian heritage and 22 full blocks of over 300 different merchants. Merchants include live music and bar scene, unique restaurant experiences, dinner and dancing, theaters, specialty food stores, and much more. Call us for more information on this unique opportunity.
, Central Location,Lane Access,Recreation Nearby,Shopping Nearby


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Robert Habermann sings some of the fantastic songs Fred Astaire and Ginger Rogers introduced into their films. The show not only covers the eight great films they appeared in but also covers the career of Astaire after Ginger left him to develop her own career.
Songs include:
- Top Hat
- Cheek to Cheek
- The Continental
- A Fine Romance
- Day and Night
And lots more memorable songs from this era.
- Tickets: £12 and £10 for concessions from www.langdondowncentre.org.uk or call 0333 1212 300
How to get there
- By train: The nearest train station is Hampton Wick - 7 minutes walk away. It connects easily with Waterloo, Vauxhall, Clapham Junction, Wimbledon and Richmond. Turn right out the station and then follow directions below as if driving from Kingston. Langdon Park is off Kingston Road, opposite Wick Road. We are in the big building on the right once you have turned into Langdon Park.
- By bus: The 281 stops outside the building, travelling from Tolworth and Kingston in one direction, and Teddington and Twickenham in the other. The 285, which links Kingston and Heathrow airport, also stops outside.
- By car: If you're driving from Kingston, drive past Hampton Wick station on the right and then take the first right after Normansfield Avenue. This isn't named on the map but is called "Langdon Park". Turn immediately right again and park in one of the spaces marked "L.D.C. Reserved Parking". Walk down the gravel path (edged with red brick) and you will come to a big red door on the left, which is the main entrance into the building. If you are approaching from the Twickenham/Richmond direction then take your first left after Holmesdale Road into Langdon Park and then carry on as above.


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Posted by Don & Shirley Hammond on 23rd Oct 2017
I am very much pleased with the new 2018 Camry Trunk carpet mat ! My new vehicle came without one, so this makes it complete ! I got very good service and fast shipping also !
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The search found 38 results in 0.022 seconds.
Conventional research in organizational theory highlights the role of board interlocks in facilitating business collective action. In this article, I propose that business collective action affects the evolutionary path of interlock networks. In particular, large market players' response after a collective action to the classic problem of the "exploitation" of the great by the small provides a mechanism for interlocks to evolve.
Durkheim's model of suicide famously includes four types: anomic, egoistic, altruistic, and fatalistic suicides; however, sociology has primarily focused on anomic and egoistic suicides and neglected suicides predicated on too much integration or regulation. This article addresses this gap. We begin by elaborating Durkheim's concepts of integration and regulation using insights from contemporary social psychology, the sociology of emotions, and cultural sociology.
Numerous studies document that higher education is associated with a reduced likelihood of depression. The protective effects of higher education, however, are known to vary across population subgroups. This study tests competing theories for who is likely to obtain a greater protective benefit from a college degree against depression through an analysis of data from the National Longitudinal Study of Adolescent to Adult Health and recently developed methods for analyzing heterogeneous treatment effects involving the use of propensity scores.
This paper contrasts two money-related stressors—debt and economic hardship—and clarifies where debt fits into the stress process model. Debt may be a direct or indirect stressor, as something mediated by psychosocial resources, and may be a potential buffer, interacting with economic hardship. The analyses use data from a two-wave panel study of 1,463 adults. One way debt is distinct from economic hardship is that debt is more common among economically advantaged groups.
For older adults, having more or closer family members in one's social network decreases his or her likelihood of death, but having a larger or closer group of friends does not, finds a new study that was presented at the 111th Annual Meeting of the American Sociological Association (ASA).
Death and mourning were largely considered private matters in the 20th century, with the public remembrances common in previous eras replaced by intimate gatherings behind closed doors in funeral parlors and family homes.
But social media is redefining how people grieve, and Twitter in particular — with its ephemeral mix of rapid-fire broadcast and personal expression — is widening the conversation around death and mourning, two University of Washington (UW) sociologists say.
The financial crisis of 2007 to 2009 was marked by widespread fraud in the mortgage securitization industry. Most of the largest mortgage originators and mortgage-backed securities issuers and underwriters have been implicated in regulatory settlements, and many have paid multibillion-dollar penalties. This article seeks to explain why this behavior became so pervasive. We evaluate predominant theories of white-collar crime, finding that theories emphasizing deregulation or technical opacity identify only necessary, not sufficient, conditions.
We know men's violence against women is costly. Yet, we know little about the costs—or benefits—of women's efforts to end it. This study investigates the temporal dynamics of women's earnings and petitioning for a Protection from Abuse (PFA) civil restraining order. Women's earnings might rise or fall at the time of petitioning but quickly return to pre-petitioning levels, a short-term boost or shock; or, petitioning might precipitate a longer-term stall or upward shift in women's earnings.
Fall 2016 Vol. 15 No. 4
Features include "Financial Foreclosures," "Fat Eggs or Fit Bodies," "God's Case for Sex," "Revisiting the Rationing of Medical Degrees in the United States," and "Activating Politics with Poetry and Spoken Word."


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Preschool at Home with Music
The Quick Start Guide
Hi! I'm Miss Danni. Welcome to MELODICminors!
Are you a busy parent struggling to figure out how to do preschool lessons at home? Are you drowning in a million toddler activities and unsure what your goals are in the first place? Are you stressed out and worried about skyrocketing expectations for your child starting school? Well, you're in the right place.
In this guide you will learn:
- The 4 aspects of your child that schools look at to determine kindergarten readiness
- The only 4 things you need to do every day to get your child ready for kindergarten without spending hours lesson planning or setting up activities
- 4 supplies for getting your day started with circle time and an easy circle time routine
- Fun music to help you and your preschooler meet all of their readiness goals with no pressure


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Doing Workstudy at O2 Since: 2012
Cemile's Thoughts on Koundinyasana: "It looks so fancy! I admit it was a 'dream pose' for me for a long time. I actually remember the first time I managed to this pose (in the Somerville studio) — I guess my surprise and suspicion of whether I had actually successfully managed it was obvious because the instructor commented on the confused yet enthusiastic face I had. Last year (I believe it was also when Koundinyasana was pose of the month), I had the exact experience but in the opposite role of the instructor — I saw that confused yet excited look of 'Wait, did I really just do it?' It felt rewarding to think that I had some aid in feeling accomplished. Also, I love that it has so many variations and is an impressive just as a transition."
We are diverting somewhat from the regular premise with this mid-month "Teacher Feature." While Cemile (pronounced "Gem-ah-lay") did complete Mimi's 200-Hour Teacher Training in 2015 and taught regularly for the following year-plus, she came off the schedule last spring so she could focus on finishing up her PhD in astrophysics at Tufts. Now that she's completed her degree, our resident rocket scientist is preparing to take on a new adventure just outside of Toronto where she'll be doing a post-doc fellowship. We've only got a few more weeks with this beautiful soul regularly in our presence, and so we wanted to give her the honor of a proper send off.
While many of you likely got the chance to take class with Cemile, even more of you may recognize her from behind the sign-in desk in Cambridge, where she's been a workstudy staff member since that studio's opening in 2012. She'd already established a regular practice at our Somerville location — "I lived very close when I first moved to Boston," she said — and so we were delighted to have her as part of the team during the process of opening the Cambridge Studio. She said, "I was pretty hooked when the Cambridge studio was announced to be opening — so I jumped in to join the community!" What that meant initially was helping out even before the general public had set a foot inside. "I still remember Cemile with a paintbrush in her hand, pitching in, helping out wherever," said Steven, one of the studio owners. Once those studio doors were open, Cemile became such a dependable, skillful, and, of course, kind sign-in staff member, we tapped her to manage the desk staff, a role she's served for the last three years. "She makes my job so much easier — she will be missed very much by all of us," said Cambridge General Manager Sarah.
Here at O2, we are so appreciative of all of our workstudy members — these dedicated individuals work behind the desk and also as part of our cleaning crew. They volunteer for two hours per week (in exchange for their yoga memberships) to help operations run smoothly at both studios and also to keep the space beautiful. Being part of this team is a great way to get more involved in the community, so if you're interested in learning more, ask for an application at the desk in either studio! We especially encourage those of you who have, like Cemile, practiced with us for awhile to apply since it's a win-win for those of us we know — and who know us — to become these key members of our team.
Cemile initially started her yoga practice with us seven years ago because she needed "something to get her out of the house, to move and breathe in a non-competitive environment." It gave her a break from her studies which had her spending her days reading and thinking about how structures evolve in the universe ("On a good day," she quips) or trying to fix the bug in a code she wrote for data analysis ("On most days," she adds). It's a bonus-beyond-measure that she opted to come to O2 for that chance to breathe and that she became such an integral part of our community. In fact….now that we're thinking about it….maybe our science-rooted name — O2, of course, being the chemical symbol for oxygen — drew her to us??? Whatever magic brought Cemile to O2 Yoga, we are thankful for it.
What's the best lesson you've learned from Mimi?
"The importance of remembering names! Seriously, try it! It made a significant impact on my social interactions! Besides the fact that it is good mental exercise, I think it is important to have people recognize that they are really seen and their presence appreciated."
What's the best lesson you've learned from teaching/working at the desk?
"Be patient with others and yourself! It seems trivial but as someone whose 'day job' is pretty solitary, I don't get the chance to practice this so often!"
What's your favorite pose to do?
"A seemingly 'simple' pose: a glorious hip and oblique stretch, spinal extension, and chest/shoulder opener all in one — Trikonasana! I find it so grounding and yet energizing at the same time."
What's your "dream pose"?
"Savasana — without the monkeys in my mind jumping around."
Any "Fun Facts" you'd care to share?
"I helped organize this year's World Naked Bike Ride in Boston — I'm pretty passionate about biking (I am somewhat proud of the fact that I've come this far without ever getting a driver's license), promoting body positivity and living sustainably!"
To learn more about our fabulous teaching staff, click here.
Originally published on August 15, 2017. View on O2 Yoga's website here.


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Evaluations of pur and brita water filters
When considering selecting a drinking water filtration system one is bound to get confused with the sheer numbers of filters in the market. There are several brands that assure thoroughly clean as well as pure water. Every model is trendy and eye capturing, however the realistic question is whether all these brand names can really provide exactly what they carbonated info guarantee. Whenever you buy bottled water, there is no assurance if its truly genuine or has been refilled from the faucet. There are not many manufacturers that can really provide most pure drinking water out of all of them, pur and brita water filter are definitely the 2 trustworthy brands.
Both Pur as well as Brita water filter systems provide top quality of pure type of water. When you buy any of these 2 you never have to be worried about pollutants and also bacteria harming you and your family. Both the brands happen to be giving excellent services for quite some time now. They are really simple to use and provide crystal clear drinking water. Out of these two, Brita needs to satisfy top quality guidelines before it qualifies for being packed as well as parceled to numerous stores. Each component is well tested prior to getting delivered to ensure that you get the most pure form of drinking water.
Although you can find sites such as Amazon in which individuals are complaining about lids and sprinkling of water out of Brita pitchers, as well as filters it is not the case usually. In case you work with the filter properly, you simply will not encounter a problem with its lid. These filters are usually sensitive and need you to definitely maintain it too. Expecting the item to work perfectly with you manhandling it every time just isn't the suitable thing. Also all these drinking water filters as well as pitchers have to be washed at regular intervals to ensure hygiene.
The actual cartridges employed in Brita happen to be easy to fix. Pur drinking water filters can provide around 40 gallons of drinking water before you need to change the cartridge. However with the Pur pitchers it will take a bit longer to get filtered water from the faucet. Brita brand offers filters as well as pitchers in a variety of sizes to fit the requirements of various people. You can locate these types of pitchers and filters in various shades and shapes. Brita has always supplied high quality pure drinking water and is hence largely recommended by happy customers.
Both Pur and Brita manufacture pitchers that are easy to store in the refrigerator. That enables you to consume pure in addition to chilled water at the same time. Even though these pitchers have got a lesser amount of capacity, it is a good way of consuming pure water. The different sizes make it easy for everyone to find filters and also pitchers of their personal preference.
In case you are puzzled over which brand to trust when it comes to purchasing water filters, I recommend you to definitely take a look at both Pur as well as Brita drinking water filters. Nonetheless, Brita is one brand which you possibly can depend on blindly and bring it home to experience the flavor of pure drinking water. Brita is the only manufacturer that offers recycling of cartridges. Also Brita continues to be excelling in after sales service for the past FORTY years and is certainly one of the most loved brand names.


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Link: https://twitter.com/colinasteph/stat...427195395?s=21
Link: https://twitter.com/ColinASteph/stat...89831379931136
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Link: https://twitter.com/colinasteph/stat...427195395?s=21
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"Everyone says you should be a good loser. If youre a good loser, youre a loser."
- John Tortorella
"Never be a spectator of unfairness or stupidity. Seek out argument and disputation for their own sake; the grave will supply plenty of time for silence."
- Christopher Hitchens
A second buyout window?
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So Buch and Trouba are eventually signing and giving the team more leeway with the cap as well?
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Yeah, they've probably been asked to file.
Somebody's getting bought out.
They can still sign before arbitration, right?
I don't think I know what filing for arbitration really means.
Edit - and after reading some posts, this is helpful to us...is that just because of the second buyout window?
Essentially, this is an "end date" with the players rights locked into that team (unless the elects to walk away from the arbitration award).
They can continue to negotiate terms up until the final decision is given by the arbitrator.
Lias Andersson for #AJT2019
A bit risky too unless there was a *understanding* between the parties before filing. Not ethical, and possibly not legal either, but certainly can happen.
Doesn't this scream Smith buy out because we couldn't trade some middle 6ers to free cap space?
They typically settle immediately before the hearing. Do they still get the second UFA period if they settle before the hearing?
I'm struggling to think of comparable players for Trouba. The $7.5+ mil per season seems kind of high to me based on his past performance. I was looking at a little more than a guy like Esa Lindell or Ristolainen. I imagined that he would come in closer to $7 mil a season when we first got him but I might end up being a mil off each year.
If we pay Trouba less than 8 I'll be absolutely thrilled. That said, I think he's worth 8.
6.5 is the number for me, or bridge him. 8 for Trouba is an over pay.
He's played a full season twice, and has been over THIRTY points only twice, and, those two facts don't even correlate. He had a season with 20 points in 80 games.
He has to played full season because of hold outs. To avoid that, lock it down long term. 7y x hopefully under 8. The lower the better.
Based on only giving up Pionk, I'm more lenient with the cap hit. (If under 8)
Lias Andersson for #AJT2019
Trouba stepped up to 50 points because he got a lot more PP time due to Buff's injury, including 10 more PP assists than he had ever had before. He clamored for opportunity. He got more, he delivered more.
On that basis, I would weight last year a lot higher than his 21 yo season (81g, 21p) - regarding it as a strong positive trend rather than a possible anomaly. He is headed for more opportunity than he's ever seen before and is potentially a lynch pin of the team. Don't pay him like you're making an arbitration argument and don't believe in him. $7.5 with reachable performance incentives.


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Gunmen suspected to be hired assassins have killed an All Progressives Congress (APC) Local Government Chairman, Mr Sunny Ejiagwu.
The victim, who was murdered on Friday morning, was until his death the APC chairman of Ideato North LGA of the state.
He was among the party's Local Government Chairmen elected in the just concluded congress held early this week in the state.
According to sources, Ejiagwu was killed along the Orlu-Akokwa Road, on his way home shortly after attending a meeting at the APC Secretariat in Owerri, the state capital.
Imo State Police Command has confirmed the incident to.
The command spokesman, Mr Andrew Enwerem, said while the police were on top of the situation, the details of the attack were still sketchy.
The Imo APC Chairman, Daniel Nwafor, also addressed reporters at the party's secretariat after the incident.
He condemned the assassination as unfortunate and unwarranted, saying it was capable of causing political chaos in the state.
Nwafor further called on the security agencies to urgently launch a manhunt for the perpetrators of the dastardly act.
He recalled that the deceased had raised fears over his safety on Thursday during one of their meetings, decrying the volatile nature of his local government.
The APC chairman, however, called on party supporters in the state to remain calm while the security agencies work to ensure the perpetrators were brought to justice.


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Exit Fullscreen
Battle for Darkness is another fantasy strategy game in which you have to fight an unholy war with bloodshed to start your evil reign of terror. Build up your army of cruel monsters and send those out to invade enemies country. The farther your troops come and the more opposing units they defeat, the more gold you will get. Use it to run upgrades or recruit new warriors between the battles. Much fun.
Controls: Mouse
Battle for Darkness is a free strategy game available online on Silvergames.com. You can play this simple battle game in full-screen using every modern browser. Battle for Darkness has been already played 50,305 times and received 84 percent positive feedback with 2,159 votes. If you like such games, you can play other online games such as Hex Empire, Stick War and World Wars 2 for free on Silvergames. If you enjoyed playing Battle for Darkness share it with your friends via Instagram and other social media.


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web sites
- BKLYN Boihood
- California Center of Excellence for Transgender Health
- Glamazon Press
- http://www.transx.at/ (Austria)
- Jamison Green – Education and Policy Consulting on Transgender and Transsexual Issues
- Labrys (Kyrgyzstan)
- Learning Trans (facebook page)
- Pembe Hayat (Turkey)
- Questioning Transphobia
- Scottish Transgender Alliance (Scotland)
- Stichting Transman (Netherlands)
- Tranny Roadshow
- Trans Lives Matter tumblr
- Trans-Academics.org
- Transadvocate
- Transfuzja (Poland)
- Transgender Law Center
- Transgender Network Berlin (Germany)
- Transgender Service Provider Network (TSPN)
- TransLatin@ Coalition
- TransperienceTV
- Transrespect versus Transphobia Worldwide" (TvT)
- Vreerwork | Gender education and trans/inter advocacy (Dutch | English)
- xQsí (Porque Sí)
Tag Archives: Philadelphia
Philadelphia Trans-Health Conference
2011 marks the Philadelphia Trans-Health Conference's 10th anniversary! We expect to see a record number of community members this coming year, and we are focusing on building creative community partnerships. Please watch http://www.trans-health.org for more conference developments as plans are finalized, … Continue reading
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