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Introducing the all-new Mercedes-Benz A-Class
The Mercedes-Benz A-Class — a brand new class, a brand new driving experience. As the first and only long-wheel based model in the premium compact car segment, the Mercedes-Benz A-Class is the clever compact car you didn't know was possible. The all-new 2019 Mercedes-Benz A-Class arrives at our Stockton dealership in fall/winter 2018. Here's what you have to look forward to:
Personality x10
Clean lines and crisp sculpting lend the A-Class an elegant confident styling with a sporty dynamic edge. The A-Class blends Mercedes-Benz classic beauty with a youthful dynamism that screams, "I'm road ready and all yours."
Space for giants
Go on, stretch out. The A-Class offers the most legroom in the premium compact segment. With four to six more inches of legroom compared to its competitors, the A-Class may be a compact car but it's got plenty of room for you and your long-legged friends.
…but it's still compact
The A-Class has legroom to spare but its compact size makes driving and parking in urban areas easy and breezy.
Ooh, that interior
Flush with innovative technologies, including climatised seats that actually adjust to the temperature and 64 different ambient lighting settings to really set the mood, the Mercedes-Benz A-Class offers a level of sophistication unseen in other sporty compacts. It's got an ample dose of class to elevate its exciting dose of sass.
What's sexier than brains?
The Mercedes-Benz User Experience (MBUX). It's like the smartest kid in the room, just without the ego. MBUX learns from your driving habits to predict how it can create a truly personalized driving experience. For example, if you make the same calls every morning on your way to work, your A-Class will have those phone numbers ready the moment you turn the ignition. Plus, with Natural Voice Control you can talk to your A-Class just as you would a friend, it will adjust to your speech patterns and deepen it's understanding of your needs over time. All you have to do is say, "Hey, Mercedes" and your A-Class is at your command.
Safety Doesn't Happy by Accident
The Mercedes-Benz A-Class turns heads and keeps the whole body safe with Mercedes-Benz Intelligent Drive. The A-Class actively works to protect you and your passengers from injury with features like Active Brake Assist with cross-traffic function. In the event of a collision, your A-Class will warn you with audible and visual alerts and brake autonomously if necessary. Plus, with Car-to-X Communication, your A-Class can communicate with other vehicles on the road to learn about and share current road conditions.
The Mercedes-Benz A-Class, a car so customizable it can be just like you. Get a glimpse of the all-new Mercedes-Benz A-Class today (and say hi Nicki!). Mercedes-Benz A-Class coming to Stockton later this year.


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The name Team Darkhorse Wheels may suggest they are outsiders at the gruelling nine-day joBerg2c mountain bike race from Heidelberg to Scottburgh next week, but Shaun-Nick Bester and Andrew Hill look like the pair to beat.
After mixed fortunes at the Epic, where the Darkhorse Wheels duo ended 25th despite Bester discovering only after the event that he had tick bite fever, the pair on Friday go into their second major stage race of the year as the favourites.
Race strategy
Hill, however, knows just how fortunes can rise and fall in a multi-day event and was careful to play down the team's chances during the race from April 26-May 4.
"Our aim for joBerg2c is, like most stage races or tours, to try to ride for the overall GC placing and try to avoid any unnecessary energy expenditure or injury and illness.
"The overall race strategy is to finish on the podium. As a team we have the necessary experience of this event and know what is required to be up there in the mix for a win. Success in such a long event almost always comes down to staying healthy and being attentive to what racing efforts should be tempered, and which could provide meaningful time gaps in the GC (general classification).
Enduro champ to ride sani2c with granddad
"This year we have definitely tried to make our season-build slightly longer in an effort to target the nine-day race. Shaun-Nick and I have worked hard in the planning phase and looked at the specifics of the race, along with the stages, to see where we can improve.
"A long event like this is all about planning and preparation."
Bester agrees, and adds that he believes their performance at the race will be due to the teamwork.
"Motivation for long events and particularly multi-day stage races is critical," said Bester. "You go through ups and downs from day to day, and even during each day you could have good and bad moments on the bike.
"As a team, Andrew and I have a great ethos and we know we can really rely on each other. There is a lot of experience between us and both of us have raced a lot.
"A podium finish would be a huge achievement for the team and sponsors. A stage win or two is something we would definitely be targeting, but to keep the momentum going over nine days requires a lot of luck and good fortune."
Unique perspective
Bester and Hill are excited about taking part in the joBerg2c which provides riders with a unique look at South Africa. It is the only race which takes competitors from the South African Highveld, through four different provinces, and ends at the coast just south of Durban.
"The journey from just outside Johannesburg to the sea is a special one for all South Africans," said Hill, "and we are excited to take our sponsors with us, hopefully with some stage wins along the way."
The route
The joBerg2C starts on Friday at Heidelberg in Gauteng and finishes nine-days later in Scottburgh on the KZN south coast. The first three stops will be in Frankfort, Reitz and Sterkfontein Dam in the Free State. The riders will then drop over the escarpment into KZN for overnight stays at Winterton, Nottingham Road, Underberg, Ixopo and finally Highflats.
The total race distance is about 900km with the bulk of the riding on district dirt roads as well as a lot of Jeep and single track. The longest day is the 121km Day 3 from Reitz to Sterkfontein, while the 97km Day 6 from Nottingham Road to Underberg has the most climbing, with 1 940 vertical metres of ascent.

subset: commoncrawl


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The Star Reps Racerback tank features a brand new design exclusive to our fall line. Lightweight jersey material for a fitted yet comfortable fit.
- Fabric laundered for reduced shrinkage
- Self-fabric binding on neck and armholes
- Lightweight breathable jersey feel
- Removeable label
- 60% cotton/40% polyester
- Printed in Chicago


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No Way! Looks like you've been crushin' a bit too hard on this style and its no longer available
Public Desire Size Guide
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Chunky biker boots are shoedrobe essential for these colder months! Formation features a chunky cleated sole and lace up front. Style 'em with distressed skinnies, oversized tee and your fave biker for the perfect laid back weekend attire.
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Cee Cee Hill, contributor
I'll start with a disclaimer. I don't like Adele's new song "Hello." That means my musical tastes are absolutely screwy compared to millions of people out there. So don't be surprised if I find Hinds' music exciting, fresh and cool.
Hinds play surf garage lo-fi music. Their songs have catchy riffs, cool harmonies, and a lot of sing-along choruses. They talk about love, flirting at parties, running after boys, or feeling sad to lose that treasured loved one. "Solar Gap" is the only instrumental song and it has that sunny, California-in-the-60's vibe.
Hinds' unique approach to songwriting craft make them a very relevant modern band, quickly garnering attention and acclaim. It's imperfect, noisy, and raw. "Leave Me Alone" sounds like it was recorded in their living room after a few drinks and joints.
For those of us that hate "Hello," The Voice and Auto-tune, listening to Hinds is refreshing.
Rating: 9 out of 12 cans of PBR!


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Antrim GAA have handed over funds to three food banks in the county to help those less fortunate during the Covid-19 pandemic.
The hurling and football squads have donated and so has the county board.
The players have urged other squads and counties to do what they can to assist people in need at this time.
"We know that everyone is experiencing their own personal difficulties at this time," said county hurler Neil McManus. "But if it is possible for you, your club or your county to help others who are vulnerable in your community, please get in touch with an organisation in your local area."
An important message and £6,000 donation to 3 foodbanks in @AontroimGAA— Antrim GAA (@AontroimGAA) April 8, 2020
If it is possible for you,your club or your county to help others who are vulnerable in your community..... pic.twitter.com/yG6nZ5tCC2


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Siberian Tit, Parus cinctus, AV2958
home > Collections > Search the Collection > Siberian Tit, Parus cinctus, AV2958
Physical Description
Study skin of a small bird with body straight, wings folded back against the body, and legs crossed. Head is tilted so that the beak is pointing up.
Field CollectionSiberia
MeasurementsMaximum dimensions (H x W x D): 25 x 28 x 136mm
All Rights Reserved


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Ardbeg Auriverdes
2006: Ardbeg Nam Beist - a vintage 1990 16-year beauty (and personal favorite)
2009: Ardbeg Rollercoaster - ten year's worth of different casks dating back to 1997 (not our personal fav, but many love this one)
2010: Ardbeg Supernova - at the time the most heavily peated scotch ever made
2011: Ardbeg Alligator - a super-charred monster (another awesome dram)
2012: Ardbeg Galileo - a 1999 12-year with the (somewhat dubious) distinction as the first malt that had been TO SPACE!
So each year Ardbeg could be counted on to deliver something decidedly unique, increasingly epic (and increasingly phallic), Obviously these special releases were an excuse for the marketing team to go a bit crazy, but each one was truly a unique bottle of whisky as well. The Supernova redefined peat the way microbreweries redefined hops, the Nam Beist was insanely delicious, the Galileo (space monkeys aside) was a seriously tasty dram. Smartly veering away from the idiosyncratic barreling trend (throwing up various wine finishes until the whisky tastes like bubble gum), Ardbeg found their distinctiveness in peat, age, char, and barrel selection.
In recent years, though, we seem to be getting more marketing and less actual uniqueness when it comes to the bottles. Last year was "Ardbog Day" which seemed to be just a NAS (no-age-statement) bottle with a funny name. No maniac peat levels, no unique barreling, not even a few molecules of yeast orbiting a planet, Nada...
Last year it was "Auriverdes" named after the whisky's gold "auri" color and its green "verde" bottle. It's also a shout out to Brazilian football in honor of the 2014 world cup. The marketing reached new heights of insanity. We went to one whisky shows where they had solid gold bottles moored to the booth in chains (seriously), and another that had a three-wheeled "Ardbeg Trike" that looked like the bastard offspring of Harley Davidson and Mountain Dew. (footnote: they didn't actually have Auriverdes at either of these shows, we had to get a sample separately. Guess they spent too much on the gold bottles and couldn't afford the actual whisky...)
Anyway here we are with the actual goods, so before we write it off let's give it a fair shot and see what's up.
Tasting Notes
Nose: Soot, smoke, and tar, with a backdrop of overripe pineapple.
Palate: Fruit oils come through in the body. Citrus, apple, melon. The sherry cask and the heavy peat carry through.
Finish: Pretty hefty spirit burn. Nice long peaty drift through the nostrils. More overripe sweetness. Not very complex but still has the heart of an Ardbeg.
Ardbeg is good, and this bottle is no exception. It's a little on the sweeter side where we tend to prefer the more peat and char-focused expressions, but that's not necessarily a bad thing for everyone. It's definitely got the big ballzy smoke we love, and it's got a nice mix of sweetness, richness, and peat. Where we bump into trouble is the cost/value. It's 2.5 times the cost of the 10-year (and in all likelyhood younger), and it's almost double the price of the excellent Uigedail. Granted the "Oogy" sets the bar very high with a delicious cask-strength vat of bourbon and sherry casks at around $55. So listen if you're an Ardbeg collector and need this for your shelf, we give you permission (it doesn't come in the gold S&M outfit, that costs extra). For the general public, we have to be honest and say that we don't feel like you're getting anything wildly special by paying this hefty price tag. It's tasty, that's for sure, but Ardbeg set the bar so high with their other limited releases that it's tough to get super excited about this one. Maybe if we got to ride on that redonkulous trike...


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Solar Electricity Advantages and Benefits
Because of the fact that oil prices are increasing, solar power are considered to be a great option for those who are looking for an alternative energy substitute. Through the help of modern technology it becomes possible to convert the energy of the sun to usable electric energy. By using the sun as the primary source of power is actually an energy resource which is found to be more than enough in satisfying the energy needs of the world. A benefit with solar power is that energy from the sun is free.
In today's economic financial state, most population appreciates the option of saving more money, especially on their electric bills. This is actually made possible through solar electricity. There's really no need for fuel or other sources of fuel, which actually makes solar power to be a cost-effective option. Some advantages with solar electricity is that there's really no need for any maintenance after the first installation process. Solar power likewise works silently and there's no smell with it. Pocosolar California solar power also is a renewable and clean energy source that doesn't come with any pollutants and it does not damage the environment. There's a high chance that our future will be supplied with solar power. An energy like this is made available to us all and it is also free.
The cost for the photovoltaic panels or solar panels are in fact expensive even with the technological advancements today, but the pocosolar company will provide the solar power equipment's for you. But, you will see that the returns of its investments far outweigh your initial investment. However, the efficiency on the collection of solar power can be affected by weather conditions. A power collection is only made possible when there's the presence of the sun, so it simply means that there's no energy consumption during the night. On the installation of solar panel systems, a large area in fact is needed in order to ensure on its effectiveness. For people who are in search for a cost-effective and efficient energy source, it's possible that solar power will be able to provide tons of benefits. You should however always remember that there are limitations to it as well.
An advantage with solar power is that this is also an environment friendly energy. This also doesn't pollute the air like what fossil fuels do. Also, you could slowly reduce on your dependence on your utility company when it comes to electricity requirements.
Because there are different benefits that solar electricity can offer and provide, many people today are now switching to this kind of renewable energy because conventional energy sources now are depleting very quickly.
More ideas: http://www.pocosolar.com/


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Another Crash
Yet another crash, at exactly the same spot as the day before yesterday! I tried to fly to the beautiful tree in front of the house, and again something hit me. Jan kept saying he should have "closed the curtains", but Hilke and Sophia said I have to "get used to the windows in the house". It was all very confusing, but I think I have to conclude that the tree over there is out of reach for me.


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Everyone knows that listening to music can be calming, a steady rain can induce sleep, and white noise can help keep focus at bay. But sound therapy has a long history and is being used as a successful form of therapy in many conditions. Let's start by focusing on one of the science that has studied sound and its effect on the human beings; psychoacoustics!
Psychoacoustics is the study of the perception of sound. It explains how we listen, our psychological response to sound, and the effect of sound and music on the nervous system. It has emerged in the 1940s with the work of the French physician Alfred Tomatis, MD and recognized by the French Academy of Science and Medicine for his revolutionary research and clinical work in the area of hearing and sound.
Based on decades of studies, researchers have proven that specific frequencies can indeed be used to heal and enhance our lives; especially against stress, to improve mental productivity, accelerate learning, minimize pain, facilitate healing, etc. This is pretty amazing, and I'm still not sure why the findings below are not mentioned in medicine studies or even in our anatomy's classes at school…
Sound therapy is based on the principles of frequencies, resonance and entrainment[1], thus bringing a physiological and neurological response in the brain and body.
Dr. Alfred Tomatis' most groundbreaking findings relates to the fact that the ear not only serves to listen, to communicate and to aid in our balance, but that its primary purpose is to convert sound waves into electro-chemical impulses that charge the neo-cortex of the brain. According to him[2], a deficiency in specific frequencies is the root cause of many ailments. The good news is that we can retrain the middle ear to the full spectrum of frequencies and therefore heal or improve those issues. He was indeed the first doctor to prescribe sound frequencies in lieu of pharmaceuticals!
"An open ear can assimilate more of the nutrients of sound – thereby facilitating stimulation of the brain and nervous system. The effects of limited tonal or sequential processing may have a definitive impact on learning, mental and physical wellness" (A.Tomatis, PhD Paris School of Medicine)
After him, Dr. Robert and Alex Doman (dad and son, US neurologists working with neuro-developmentally delayed children) worked from Tomatis' findings and developed it further with years of experiments in their clinics and with the help of other doctors and experts. They found that Sound therapy was actually the best ways to treat these kids, and they prove that music and sound can indeed unlock human potential in great ways, for healing purposes as well as enhancing performances and general well-being. And that's not all, but we'll go more in details in the next Sound Science post! 🙂
Here are the 4 major findings from the Psycho-acoustics researches:
- Pure Sound vibrations and Music are nutrients for the nervous system, like food and liquids are for our physical body;
- There are different types of sound; those who charge and energize us and those who drain us;
- The auditory mechanism is not just a process that helps us to hear and communicate; it's indeed a mega-portal to the brain;
- Specific sonic tools can be developed, based on the principles of resonance, entrainment, frequencies filtering and gating, and these tools do empower health, learning and productivity. Most of them, such as the Tomatis Method, use headphones as a medium, because different frequencies can be played in each ear, creating ELFs (Extremely Low Frequencies) which are affecting brainwaves. However, acoustics sounds are usually preferred to digital sounds[3]. The sonic solutions usually recommended in the field of psychoacoustics consist of specially reinforced and filtered music and sounds. And the results achieved by the thousands of centers around the world are actually startling (Tomatis centers, music therapy associations, Brain-Sync, Monroe Institute, etc.).
[1] Resonance: The effect of one vibration on another. Entrainment: Changing the rate of brainwaves, breath or heartbeat by matching an external periodic force (rhythm, frequency, etc.) [2] And proven right by many after him, such as Dr. A.Doman, P.Joudry, Dr. G.Berard, etc. [3] The Gong is one of the best acoustic sound to listen to, as it creates a huge amount of ELFs, allowing the brain to entrain with the best wave available for it and therefore switching to either full relaxation, pure meditation, deep sleep, or whatever feels best at any given time.
Sources: Mitchell L. Gaynor, M.D., 'Sounds of Healing', Broadway Books, 1999 / Joshua Leeds, 'The power of sound', Healing Arts Press, 2001
firstname.lastname@example.com, www.sanasuma.co.uk, FB: @www.sanasuma.lk
Sound events in March:
-Sat 24 Mar, 4-5.30pm, Sound Relaxation @ Prana Lounge, 60 Horton Place, Col.07, Rs.2,000/- (Rachel, firstname.lastname@example.com)
-Thu 29 Mar, 6-8pm, How to play gong – A practical session, @ 9 Greenlands Lane, Col.05, Rs.2,500/- (Hari Karam & Madeleine)
-Sat 31 Mar, 6.15-7.30pm, Sound Relaxation @ Om Shambala, 143 Fife Rd, Col.05, Rs.2,000/- (Rachel, firstname.lastname@example.com)
-Sat 31 Mar, 6-7.30pm, Gong Bath @ Sri Yoga Shala, Thalpe, Galle, Rs.2,000/- (Fiona, email@example.com)


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Mr. Michael Bell holds a Bachelor of Arts in Philosophy from Slippery Rock University and is currently completing his Masters of Divinity at Shepherd's Theological Seminary. Mr. Bell's knowledge of the Bible and study of philosophy enhance the classes he teaches at our upper school.
Mrs. Sarah Bell holds a Bachelor of Science in English from Slippery Rock University. Mrs. Bell's love for children and for Christian education makes her 1st grade class a place children love to be.
Mrs. Shelah Bowers holds a Bachelor of Arts in Missions and Elementary Education from Pensacola Christian College. Mrs. Bowers' teaching experiences and service in Brazil bring excitement to her elementary Spanish and Music classes.
Mrs. Crystal Braxton holds a Bachelor of Science in Early Education from the University of North Carolina at Greensboro. She creates a loving, nurturing environment in her kindergarten classroom.
Mr. Bridgers has a Bachelors Degree in Elementary Education from Northland International University and is currently finishing his Bachelors Degree in Business Administration from Liberty University. He has taught elementary grades at Schaumburg Christian School for 6 years and served for several years as Director of the Day Camp. During his time serving as a Director, God placed on his heart to transition to the business side of Christian Education. Mr. Bridgers is thankful that God has called his family to SCS.
Ginny Brown serves as the Upper School Art Teacher as SCS. Mrs. Brown has a BA in Art and Psychology from Wake Forest University. She gives credit to her high school art teacher for inspiring her to pursue a career in art. Mrs. Brown worked as an artist for licensing firms, magazines, and has taught art to students in the home school community since 1990. She and her husband have three grown daughters and live in Clayton.
Mrs. Emily Cain has studied Business Administration at NC Wesleyan College and Medical Office Administration at Nash Community College where she earned multiple certifications in Medical Finance Administration. In addition to her cheerful and professional disposition, Mrs. Cain brings over 12 years of experience in Executive Administrative Assistance to the Upper School.
Mrs. Jenene Davis holds a Bachelor of Science in Religious Education from Faith Theological Seminary and a Master of Education in Administration and Supervision from Liberty University. Mrs. Davis' love for children of all ages and dedication to mentoring her staff is rooted in her unyielding love for her Savior, which is evident in her servant's heart. Mrs. Davis serves as the Elementary Principal.
Mr. Chris Dentel has a Bachelor of Science in Business Administration with a minor in History from Toccoa Falls College, a Master of Education in Teaching and Learning from Liberty University, and a M.B.A. from the University of Mississippi. He has been working in education since the 2004-05 school year and has filled different roles in schools in North Carolina and Qingdao, China.
Mrs. Dentel has a Bachelor of Science in Middle School Math and Science from Toccoa Falls College and has seven years of teaching experience. Mrs. Dentel has a passion for soccer and organization. She has spent thirteen years coaching soccer both at Clayton Middle School and the International School of Qingdao in China.
Mrs. Mari Dew has her college degree in Early Childhood Development from Piedmont International University. Mrs. Dew is half Hispanic and teaches Upper School Spanish. Her passion is teaching and she appreciates the opportunity at Southside Christian School to work with the students, parents and staff.
Mrs. Pati Edwards received her Bachelor of Science in Elementary Education from East Coast Bible College/Lee University and her teaching certification from the University of North Carolina at Pembroke. Mrs. Edwards teaches Middle School English and Bible as well as our Upper School Music Instruction.
Heather has a Bachelors degree in Child Development from Meredith College and Masters degree in Early Childhood Studies from Walden University. She loves to create a fun and nurturing environment for her students so they can learn and grow to the best of their abilities. Heather looks forward to meeting the families of SCS and serving with the SCS Team.
Mr. Gatewood has a Bachelor's of Science Degree in History from Campbell University. He has spent the last eleven years teaching individuals with disabilities in the Wake Tech Community College system. Mr. Gatewood enjoys being part of an environment (Christian school) that places God's teaching at the forefront of educating our children. God has opened a new ministry for Mr. Gatewood this year and he is looking forward to serving as a teacher and as a coach with boys soccer and baseball.
Miss Becky Ham received her Master of Arts in Teaching in Secondary Education from Liberty University. Middle school students enjoy connecting with her through English and Literature classes as well as in their free time.
I attended Greenville Christian Academy for 13 years where the Lord greatly shaped my life. After graduating, I attended Southeastern FWB Bible College where I received my under grad with a major in Pastoral Theology. Some of the most pivotal influences in my life came when I was in my teenage years at my Christian school. My prayer is that the Lord allows me to be this person for a student at Southside while working with them in athletics. The Lord has blessed me with a beautiful wife Emily, our son and my little buddy Cooper, and sweet little baby girl Skyler. I pray God uses me to be an influence in the future years at SCS.
Mr. Helm holds a B.A. degree in Theater and Vocal Performance and a B.S. degree in Philosophy from Bridgewater State University in Bridgewater, MA. He is a certified educator through the state of MA for communication and literacy grades K-12 and is excited to now be a North Carolinian! His passion for teaching began in 2005 when he became an ESL tutor to the village of Bassan Caiman in Northern Province of Haiti. Joseph feels extremely blessed that the Lord has brought him to the Southside Christian community! The love of Christ should be free to everyone and Joseph wants to help spread that love and acceptance. He loves to sing, laugh, and have enlightened conversations with his students on various topics.
Miss Tammy Holdren serves as the K4 teacher at SCS. She holds a Bachelor of Arts in Education from Liberty University and served almost a decade teaching in Peru.
Mrs. Camden Keene is a graduate of Pensacola Christian College with a Bachelor of Science Degree in Elementary Education. Camden's heartbeat has always been for children- to see them learn academically, but more importantly, to help them grow spiritually. Mrs. Keene counts it a privilege to be apart of the SCS ministry and looks forward to the influence for the Lord that she will have in the lives of the SCS Elementary students.
Mrs. Karen Khamis holds a Bachelor of Arts in English/Writing Arts and a Master of Education from the State University of New York at Oswego. Mrs. Khamis has more than a decade of experience in Christian education and teaches 3rd grade at SCS.
Mrs. Krauss received both her BA in Foreign Language and her MSEd from the State University of New York in Oswego. She has been in Christian education since 1994, and she has been teaching at Southside Christian School since 2011. Mrs. Krauss also coaches the SCS swim team, and her husband has coached both boys and girls basketball. Her son, Daniel, graduated from SCS in 2018 and currently attends Liberty University. Her daughter works for Liberty University's Online Academy.
Mrs. Rebecca Lambert has a Bachelor of Art in Mathematics with an emphasis in Secondary Education from Cedarville University. She brings over 30 years of experience in teaching Math and Science from a Biblical perspective. She looks forward to fostering a love of learning in her students at Southside Christian School.
Miss Tasa McGowan holds a Bachelor of Arts in Elementary Education from Southeastern Free Will Baptist College and is currently completing her Masters in Education at Columbia International University. Miss McGowan's experience teaching in China for several years enriches her upper school classes.
Mrs. Jennifer McLean holds a Bachelor of Science degree in Office Administration from Bob Jones University. Mrs. McLean enjoys teaching the 6th grade girls Bible class, subbing in our upper school, helping with our learning support program, and helping out wherever needed on the upper school campus.
Mr. Meyer received his Bachelor of Arts degree from Waynesburg University. He has a passion for teaching history and Bible. Mr. Meyer's passion for studying Scripture and applying it to everyday life will help enhance the lives of SCS students and further develop the strong Christian worldview foundation of SCS graduates.
Mrs. Lauren Morris holds a Bachelor of Science degree in Elementary Education from Bob Jones University. Her love for Christ and her students make her classroom an exciting and welcoming place to learn. She looks forward to challenging her students spiritually and academically, and serving alongside the teachers and families at SCS.
Mrs. Ownley holds a Bachelor of Arts in History with a minor Social Work from Campbell University. She has a great love for Christian education and enjoys seeing children grow closer to the Lord, while also receiving a strong education. She is excited to embark on this new journey at SCS as one of the second grade teachers.
Mrs. Jordan Pardo holds a Bachelor of Art in Religious Studies from North Carolina State University. She has experience teaching grades K, 1st and 2nd as well as International experience in the Philippines. Mrs. Pardo is looking forward to creating a family atmosphere at SCS with her elementary students.
Dr. Patton is the SCS Head of School. He is married to Mary Ellen and they have four children and six grandchildren. Dr. Patton has served in Christian schools in PA, FL, TN, and NC for the past 28 years. He is a graduate of Liberty University for his undergraduate degree, from Temple University for his M.B.A., and from Liberty University for his doctoral degree. His life verse if Romans 12:1,2 and he is grateful for the opportunity to lead SCS into a new chapter in the life of the school. A chapter that recently saw the school become an independent Christian school and land purchased to build a new consolidated campus.
Mary Ellen Patton has served in Christian schools with her husband, Dr. Patton the past 28 years. Mary Ellen loves seeing students become engaged and exciting about learning in the area of technology. She has a nursing degree from Clarion University. Mary Ellen also finds professional and faith fulfillment in serving the needs of International Students. Mary Ellen and her husband were first called to serve the Lord in Haiti and through that calling, the Lord redirected their lives into Christian education. The Patton's have four grown children and six grandchildren.
Mrs. Pettet serves as the Substitute Coordinator for the Elementary and the Upper School programs and also substitute teaches as needed. She loves interacting with children and students of all different ages at Southside! Mrs. Pettet especially loves the freedom to speak about and share the love of God in her service at SCS.
Mrs. Mandy Pratt holds a Bachelor of Arts in Practical Christian Training with a minor in Childcare from Bob Jones University. Mrs. Pratt also holds a Masters of Education in Educational Leadership from Southeastern University. After serving in an administration role with Dr. Patton, Mrs. Pratt joined SCS this past year to teach middle school English, literature, and Bible.
Mrs. Beth Purdum serves as the Upper School Substitute Teacher and on those days when a substitute is not needed, Beth provides office support in the US Program.
Mrs. Angie Register has a Bachelor of Arts degree in Psychology from East Carolina University. She has an Associate degree in Nursing from Pitt Community College. She is a nationally Certified Emergency Nurse. Mrs. Register is currently enrolled at Chamberlain University for her Master's degree in Nursing to become a Family Nurse Practitioner. She loves children and is currently teaching physical education for the elementary school.
Mr. Riegel began his undergraduate studies in Astrophysics in Pennsylvania before receiving God's call to ministry by transferring to Southeastern Baptist Theological Seminary. He holds a Bachelor of Arts in Christian Studies with a minor in Biblical Studies and he plans to complete his Master of Arts in Biblical Languages from SEBTS in December 2019. He loves both learning and teaching and is excited to join the Southside Warriors family.
Mrs. Jo Scott received her Bachelor of Science in Child Development and Family Relations from East Carolina University. Mrs. Scott's extensive experience and love for young people make her kindergarten class an engaging place to learn.
Mrs. Cherie Settle holds a Bachelor of Science in Business and Human Resources from the University of Phoenix and made a lateral entry into the field of education. She gained her teaching certification through ACSI. As a life-long learner, Mrs. Settle continues to take classes through East Carolina University. Mrs. Settle moved from the ES Classroom the summer of 2019 to join the SCS Leadership Team and now serves as our Human Resource Coordinator and other areas of support within the SCS Business Office.
Ms. Tracy Shouse holds a Bachelor of Science in Education with a concentration in Special Education from East Carolina University. She has also begun her master's degree at Old Dominion. Ms. Shouse's experience working with children in Christian education makes her 2nd grade classroom and fun learning environment.
Mr. Totten holds a Bachelor Degree from Liberty University with a major in youth ministry and a minor in music. He served as a youth pastor for 23 years in several churches in Wisconsin and Ohio. Mr. Totten is a proud veteran having served in the U.S. Air Force. He loves teaching students and has a passion to see young people succeed both academically and spiritually.
Miss Melanie Turk teaches high school general and honors science courses. She earned a Bachelor of Science in Biology Education from Purdue University and a Master of Arts in TESOL from the University of South Florida.
Mrs. Wolfe holds a Bachelor of Science in Economics from Fairmont State University and has worked in retirement services, executive administration, and process auditing. She has homeschooled her children and taught in various home school co-ops for fifteen years. She and her family love music and lead worship at their church every week.


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When you're a vehicle owner, oil changes are just a fact of life. Every 3,000-5,000 miles or so, you have to bite the bullet and take your car in to empty out the bad stuff and get clean new oil put in. But while routine maintenance is necessary, it doesn't have to be a pain, especially if you come out to Walla Walla Valley Honda for a Honda oil change. Walla Walla Valley Honda's service department offers a number of essential repairs and procedures for Honda vehicles and all other makes and models. We'll get you all fixed up and back on the road in no time.
While you can change the oil on your own, getting it done at our service department near Kennewick will result in a fast turnaround and guarantees the use of only genuine replacement parts.
Depending on your vehicle and the kind of oil you used last, getting it changed every 3,000-5,000 miles is a good rule of thumb.
Nothing beats getting your oil changed by a highly trained professional, especially the ones employed here at Walla Walla Valley Honda near Kennewick.
In addition to oil changes, our service department near Tri-Cities is equipped to handle a wide range of routine maintenance, from tire replacements to general repair. We also offer rotating service specials, which will often include Honda oil change coupons, along with great deals on other routine procedures.
Whether you're getting your oil changed or repairing a broken part, the service department at Walla Walla Valley Honda will get it done and get it done right. Contact our service department directly to schedule an appointment, and we'll find a day and time that works best for you. For more information, feel free to contact us online! We're always here to answer any questions you may have, whether you're looking for Honda Civic oil change price info or the Honda oil change price for any other model.
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In most states, it's required that anyone who owns a motor vehicle have some form of auto insurance—and even if your state doesn't require it, it's still something we highly recommend. Auto insurance is a great way to protect yourself from any financial calamities that might come following a highway accident. But what kind of insurance should you buy—and how do you know you're getting the best deal?
Different Types of Auto Insurance
If only there was one single type of auto insurance—that would be so simple! In reality, there are a number of different options you'll need to consider. While you don't necessarily have to have all the coverage listed here, you should definitely think about your risk potential, and make certain you're not underinsured.
Liability coverage. There are two types of Liability coverage—Bodily and Personal Property. These help pay for damages done to another party's vehicle, or for injuries the other party sustains, should you be at fault in an accident.
Collision coverage. Collision coverage helps you pay for any repairs to your vehicle, in the event that you hit something—whether it's another vehicle or just a stop sign.
Comprehensive coverage. Comprehensive coverage pays for things that other policies won't—such as hail damage, car break-ins, etc.
Uninsured/Underinsured Motorist coverage. Should you ever be hit by a driver who doesn't have any insurance—and thus, doesn't have any way to pay for damages to your vehicle—this type of coverage will help you out.
Medical coverage. Following an accident, a Medical policy will pay for the medical expenses of you or any passengers in your vehicle who sustain injuries.
Personal Injury Protection. Personal Injury Protection works like Medical coverage, but encompasses much more—such as funeral costs, lost wages, and so forth.
Getting the Best Deal on Auto Insurance
Even after you determine what kind of coverage is right for you, there are still some choices you're left with—like which auto insurance company is the best fit.
There are a number of places you can turn for a recommendation—including friends and family. Also ask doctors or call around to body shops and personal injury lawyers, to see if they have any insurers they can endorse.
Be sure you shop around, and don't just accept the first insurance product you see. Also be sure you don't compare apples and oranges. Company A may offer you a much better price than Company B—but if the coverage is more limited, it may not be the best value.
Finally, take insurance into account as you budget for your next vehicle—and, as always, reach out to Get My Auto if you need help finding the best value on used cars. We're here to connect you with a reputable used car dealership near you! Contact Get My Auto today!


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What makes a great candidate for our summer program?
Great applicants do not need to have experience in entrepreneurship, but need to have shown self-initiative, resilience, problem solving capacity, and teamwork skills that show the propensity for great entrepreneurial capacity.
**Notice that grades and awards don't make the list! Yes, we ask you to submit your transcripts, but this is the least important part of the application.


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| 16.3°C Dublin
At least 18 people have been killed in a car bomb blast in Idlib, Syria's largest rebel-held city, activists and a war monitoring group said.
The Britain-based Syrian Observatory for Human Rights said the car bomb was detonated on Sunday evening.
Photos and video from the activist-run Thiqa News Agency and Baladi News Agency showed heavy damage along what appears to be a major avenue in the city, with several buildings damaged and vehicles overturned.
Ambulances and the fire brigade are seen arriving at the scene.
No group immediately claimed responsibility for the bombing.
The city and Idlib province are controlled by several rebel factions and insurgents vying for dominance, the most powerful being an al Qaida-linked group.
The bombing came after Syrian television said the country's military had recaptured Sinjar, a strategically important town in Idlib province, in its latest advance into rebel-held territory this year.
The state-affiliated Al-Ikhbariya TV said government forces took Sinjar on Sunday.
The Syrian Observatory for Human Rights said the gain "opens the road" for government troops to march on the rebel-held Abu Zuhour air base about 12 miles to the north.
The military has assigned one of its top commanders to lead the offensive into Idlib, the last major stronghold for rebels in northern Syria.
The UN said more than 2.5 million people are currently living in Idlib, including more than one million displaced by fighting from other parts of Syria.
PA Media


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Treasury Secretary Admits Being Wrong
Nov 12, 2008
Who would have seen it coming? The smart guy from Goldman Sachs was wrong? And he admits it?
It was, of course, an easy mistake to make. Who could have figured it out earlier? The author of the article says,
"Soon after he proposed the idea that the only way to save the financial system was to spend $700 billion in reverse auctions to buy toxic waste from financial institutions, I became convinced it would not work.
"Why? Because there was no way to put a solid price on those assets. If the Treasury bid more than they were worth to the bank, then the taxpayer would take a loss. [Go figure!] If the Treasury bid less than what the bank thought the assets were worth, then the bank would need to write off that loss against its capital. Since it would not be able to raise more capital, the bank would become a zombie."
I wonder how many brain cells it takes to come to those conclusions. Two or three, perhaps? It appears that the Treasury Secretary used all three of those brain cells in this case.


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This all-purpose salve is good for so many things. The coconut oil and olive oil bring nourishment, while the beeswax is known to lock in moisture, foster cells, and protect skin from damaging environmental factors. Tea Tree oil is renowned for it's cleansing and rejuvenating effect on the skin and the lavender oil is known to be universal and can help in so many ways. When combining all of these ingredients you have a pretty good weapon to aid in relief.
ingredients:Cocos nucifera oil, olea europea oil, cera alba, calendula, melaleuca alternifolia leaves oil, lavendula officinalis flowers oil.


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I'm sure many of us have been venting about that trailer for The Giver. We did it in Currently Kittah's post of the trailer here on GT earlier and I haven't seen anyone say anything good in Burt's mainpage write-up.
But, now this piece from Entertainment Weekly goes into incredible detail explaining everything we can say appears to have been fucked up in the 90 seconds of trailer we've seen.
I will say this: I used to be one of those people who would shake my head and laugh when fans of a book would complain about changes in film adaptations. The Giver has pretty much cured me of that.
Thanks, Jeff Bridges.


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Novel Junctophilin-2 Mutation A405S Is Associated With Basal Septal Hypertrophy and Diastolic Dysfunction
Author + information
- Received September 27, 2016
- Revision received October 5, 2016
- Accepted November 1, 2016
- Published online February 27, 2017.
Author Information
- Ann P. Quick, BAa,b,
- Andrew P. Landstrom, MD, PhDb,c,
- Qiongling Wang, PhDa,b,
- David L. Beavers, MD, PhDa,b,
- Julia O. Reynolds, BSa,b,
- Giselle Barreto-Torres, PhDa,b,
- Viet Tran, MDd,
- Jordan Showell, BSa,b,
- Leonne E. Philippen, MSca,b,
- Shaine A. Morris, MD, MPHc,
- Darlene Skapura, BSa,b,
- J. Martijn Bos, MDe,
- Steen E. Pedersen, PhDa,
- Robia G. Pautler, PhDa,
- Michael J. Ackerman, MD, PhDe and
- Xander H.T. Wehrens, MD, PhDa,b,d,∗ (wehrens{at}bcm.edu)
- aDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas
- bCardiovascular Research Institute, Baylor College of Medicine, Houston, Texas
- cDepartment of Pediatrics (Cardiology), Baylor College of Medicine, Houston, Texas
- dDepartment of Medicine (Cardiology), Baylor College of Medicine, Houston, Texas
- eDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota
- ↵∗Address for correspondence:
Dr. Xander H.T. Wehrens, Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, BCM335, Houston, Texas 77030.
Visual Abstract
• A JPH2 A405S mutation was found in a human HCM patient.
• A novel echocardiographic imaging plane revealed septal hypertrophy in a mouse model bearing the human JPH2 mutation, thereby causally linking it to HCM pathogenesis.
• This alpha helical JPH2 mutation resulted in decreased transverse tubule regularity and aberrant calcium handling in septal cardiomyocytes.
Junctophilin-2 (JPH2) is a structural calcium (Ca2+) handling protein, which approximates the cardiomyocyte transverse tubules (TTs) to the sarcoplasmic reticulum. This facilitates communication of the voltage-gated Ca2+ channel and the ryanodine receptor RyR2. A human patient with hypertrophic cardiomyopathy was positive for a JPH2 mutation substituting alanine-405—located within the alpha helix domain—with a serine (A405S). Using a novel mouse echocardiography plane, we found that mice bearing this JPH2 mutation developed increased subvalvular septal thickness. Cardiomyocytes from the septa of these mice displayed irregular TTs and abnormal Ca2+ handling including increased SERCA activity.
Hypertrophic cardiomyopathy (HCM) is the most common cause of sudden death in young athletes and a major cause of sudden cardiac death in the young (1). HCM is characterized by clinically unexplained left ventricular (LV) muscular thickening that can lead to diastolic dysfunction in the setting of preserved, or hyperdynamic, ejection fraction (2). HCM is also associated with varying degrees of myocyte disarray and interstitial fibrosis development, and conveys an increased risk of ventricular tachycardia and sudden cardiac arrest. Traditionally considered a genetic disease, HCM often arises from mutations in 1 or more sarcomeric genes, which encode proteins responsible for the myofilaments required for normal cardiac contraction. Despite the clear association between sarcomeric protein mutations and the HCM phenotype, controversy still exists over the molecular mechanism of HCM pathogenesis.
A growing body of evidence suggests that sarcomeric mutations may also perturb intracellular Ca2+-signaling or myofilament Ca2+-sensitivity in a prohypertrophic manner (3). Further, recent studies have linked Ca2+-regulatory and Ca2+-sensitive proteins to sarcomeric gene-negative HCM (4). This heterogeneity in both molecular substrate and genetic etiology is reflected in clinical phenotype heterogeneity. Indeed, varying morphologies of LV hypertrophy have been identified, which can cluster in families, and may be related to underlying genetic defects. Although some genotype–phenotype-based studies have linked various septal morphologies to the presence or absence of sarcomeric mutations (5), the molecular underpinnings of region-specific LV hypertrophy remain unexplored due to lack of robust experimental models.
Initiation and coordination of myofilament contraction is a major role of Ca2+ within the cardiac myocyte and is highly regulated. Opening of the voltage-gated L-type Ca2+ channel at the sarcolemma allows for an influx of extracellular Ca2+ across the cardiac dyad. This triggers Ca2+ release from the sarcoplasmic reticulum (SR) via RYR2-encoded ryanodine receptor type 2 (RyR2) in a process known as Ca2+-induced Ca2+ release (6). Junctophilin-2 (JPH2) is a component of the junctional membrane complex, which physically and functionally couples the sarcolemma and the SR for efficient Ca2+-induced Ca2+ release and excitation–contraction coupling (7,8). In addition to a structural role, JPH2 negatively regulates gating of RyR2 and loss of wild-type (WT) JPH2 expression is associated with cardiomyocyte hypertrophy, progressive heart failure, and deranged Ca2+ signaling through SR Ca2+ leak (9,10).
These prior studies have suggested that JPH2 plays an important regulatory role in Ca2+ handling and can play a direct role in the pathogenesis of cardiac remodeling. This possibility is supported clinically by the identification of a small number of individuals with HCM who have mutations in JPH2, and do not host mutations in one of the canonical sarcomeric genes (11). Despite these early studies, the mechanism of JPH2-mediated hypertrophy remains unexplored, and there have been no JPH2 murine models that have recapitulated clinical HCM. Further, given recent advances genetic analysis platforms and the identification of significant variation in JPH2, and other HCM-associated genes, there is a need for experimental models that reflect genetic disease (12).
To this end, we report a novel JPH2 mutation identified in a proband with basal septal hypertrophy who was sarcomeric mutation negative. Novel advanced cardiac imaging protocols using specialized echocardiography as well as cardiac magnetic resonance imaging (CMR) of a murine model demonstrated progressive LV and septal thickening reflective of the proband's septal morphology. Histological analysis confirmed cellular hallmarks of HCM. Studies at the cellular level revealed unperturbed excitation–contraction coupling, but a reduced level of transverse tubule (TT) organization in the JPH2 mutant transgenic mouse model. Thus, a novel JPH2 mutation was causally linked to a distinct phenotype also found in the human mutation carrier, consistent with heterogeneity in the molecular basis of HCM on the basis of specific gene defects.
Additional detailed methods are available in the Supplemental Appendix.
Genetic analysis of a large cohort of subjects with HCM
Following receipt of informed consent and enrollment of the subjects into this institutional review board approved–approved study, 778 patients were evaluated in the HCM Clinic at the Mayo Clinic (Rochester, Minnesota). Clinical evaluation of the probands comprising this cohort was conducted as previously described, and each patient met the clinical diagnostic criteria for HCM (13).
Mouse model of JPH2 variant
All animal studies were done in accordance with protocols pre-approved by the Institutional Animal Care and Use Committee of Baylor College of Medicine. Pseudo-knockin (PKI) mice heterozygous for the mutant JPH2 variant were developed as described (9). Transthoracic echocardiography of anesthetized mice was performed (14). A novel echocardiography plane was developed to better image the base of the interventricular septum and the LV outflow tract. In addition, mice underwent CMR in a Bruker BioSpin 9.4-T magnet (Bruker BioSpin, Karlsruhe, Germany). ParaVision 5.1 (Bruker, Billerica, Massachusetts) was used to collect bright-blood fast low-angle shot cine images (15).
Statistical analyses
For analyses that evaluated 1 sample per subject (mouse model echocardiography and CMR, histology of interventricular septum and free wall diameter), WT and mutant JPH2 mice were compared using Mann-Whitney U test analysis or Kruskal-Wallis test when comparing more than 2 groups. In cases of repeated measures of the same subject (calcium studies, TT power, histological assessment of areas of interventricular septum and ventricular free wall, SERCA2a activation, hemodynamic studies), WT and mutant mice were compared using generalized estimating equations accounting for correlated outcomes. Analyses were performed using SPSS version 24 (IBM, Armonk, New York).
Identification of the A405S mutation in JPH2 in a HCM patient
Comprehensive genetic analysis of the JPH2 gene in a large cohort of 778 HCM patients revealed an alanine to serine point mutation at residue 405 (JPH2-A405S) in single proband with HCM (Figure 1A). There was no family history of HCM or sudden death in the immediate family including all first-degree relatives. Both parents could not be reached or declined consent for genotyping. This mutation was absent in 159,358 reference alleles. Moreover, mutations in 9 canonical sarcomeric genes associated with HCM (Supplemental Appendix), as well as PRKAG2, GLA, and LAMP2 genes, were excluded in this patient. The A405S mutation is localized to the alpha helical domain of JPH2, which is thought to serve as a molecular tether and spring to maintain critical cardiac dyad distance (Figure 1B) (16). This residue and the surrounding protein domain are highly conserved across species (Figure 1C). The mouse residue corresponding to human A405 is the alanine at position 399, thus, the equivalent mouse genome mutation is A399S in JPH2.
Clinical imaging studies reveal distinct HCM phenotype in proband
The proband carrying the JPH2 mutation is a Caucasian male diagnosed with HCM at 16 years of age after presenting with shortness of breath, chest pain, and dizziness. His electrocardiogram revealed sinus rhythm with left anterior fascicular block with ST-segment and T-wave abnormalities and a QTc of ∼510 ms (Supplemental Figure 1). Transthoracic echocardiography demonstrated basal septal hypertrophy with an interventricular septal thickness of 23 mm (Figures 2A and 2B). Dynamic left ventricular outflow tract obstruction with systolic anterior movement of the mitral valve was noted at diagnosis which progressed to a resting gradient of 41 mm Hg with Valsalva, which increased to 88 mm Hg with amyl nitrate (Figures 2C and 2D).
Bright-blood CMR demonstrated asymmetric LV hypertrophy, which was most pronounced in the basal septum with dynamic subaortic obstruction (Figures 2E and 2F). Functional CMR with gadolinium demonstrated delayed myocardial enhancement indicative of fibrosis (Figures 2G and 2H). Due to the pronounced septal hypertrophy, systolic anterior movement of the mitral valve leaflet, and symptoms of severe exertional dyspnea, chest pain, and dizziness, the proband ultimately underwent surgical myectomy for symptomatic management.
Development of a mouse model of the HCM-associated JPH2 mutation
To assess whether the JPH2 mutation A405S in the patient with HCM is causally linked to this cardiac disorder, we generated a mouse model of the corresponding mutation, A399S, in mice. First, transgenic mice were generated expressing transgenic A399S mutant or WT JPH2 in the heart only, which increased the total cardiac JPH2 levels (Supplemental Figure 2). Therefore, the transgenic mice were crossed with cardiac-specific JPH2 knockdown mice to generate PKI mice that express stoichiometric JPH2 levels similar to nontransgenic (control) mice (Supplemental Appendix, and Beavers et al. [9]). Western blot analysis revealed that cardiac JPH2 levels were similar in WT-PKI (WT from hereon in paper) and A399S-PKI (A399S) mice (Supplemental Figure 2).
To determine whether A399S mice developed signs of HCM, echocardiographic imaging was performed using standard short-axis B-mode measurements at the level of the LV papillary muscles (14,17). There was no significant change in the LV outer diastolic diameter in A399S mice (median 5.93 mm, interquartile range [IQR]: 5.70 to 6.14 mm, n = 10) compared with WT mice (median 5.83 mm, IQR: 5.79 to 5.94 mm, n = 10; p = 0.39) (Figures 3A and 3B). There were also no significant differences in LV posterior wall thickness in systole and diastole, as well as other structural indices (Supplemental Table 1). Moreover, there were no significant differences in cardiac contractility using M-mode measurements. The ejection fraction was not significantly reduced in A399S (median 52%, IQR: 48% to 56%, n = 10) compared with WT (median 55%, IQR: 54% to 56%; p = 0.165).
Novel echocardiographic imaging plane reveals asymmetrical septal hypertrophy in A399S mice
Given the inadequate basal septum visualization by traditional M-mode measurements and the prominent basal septal hypertrophy in the proband carrying the JPH2 mutation, a novel echocardiographic imaging plane was developed to more thoroughly interrogate the LV outflow tract and basal interventricular septal region in the mouse (Figure 4). The imaging plane is analogous to the human parasternal long-axis view and clearly visualizes the basal portion of the interventricular septum and the LV outflow tract. Application of this imaging plane demonstrated a decrease in end-diastolic LV chamber area (Figures 4A and 4B). Additional analysis revealed that this is mainly attributable to an increased end-diastolic basal interventricular septal thickness, which was a median 1.22 mm (IQR: 1.16 to 1.22 mm, n = 7) in A399S mice compared with median 0.89 mm (IQR: 0.87 to 0.98 mm, n = 10) in controls (p < 0.001) (Figure 4C). This ∼37% increase in local septal thickness is a clear pathognomonic feature of HCM in patients.
CMR confirms subvalvular septal hypertrophy in A399S mice
To validate the novel mouse echocardiographic imaging plane, CMR was conducted in an independent cohort of A399S and WT control mice. The long-axis 4-chamber view revealed evidence for LV hypertrophy (Figure 5A). Quantification of the LV end-diastolic mass demonstrated enlarged LV end-diastolic mass of median 0.091 g (IQR: 0.085 to 0.099 g, n = 10) in A399S mice compared with 0.073 g (IQR: 0.069 to 0.076 g, n = 9) in WT controls (p = 0.013) (Figure 5B). Quantification revealed significantly higher septal diastolic diameters in A399S (median 1.09 mm, IQR: 1.02 to 1.21 mm, n = 11) compared with control mice (median 0.81 mm, IQR: 0.71 to 0.95 mm, n = 9; p < 0.001) (Figure 5C). This increase in septal size was not due to increased animal size because body weights were unchanged between A399S (median 29.7 g, IQR: 27.7 to 32.7 g) and WT mice (median 30.8 g, IQR: 30.6 to 32.6 g) (Supplemental Table 2).
JPH2-A399S mice demonstrate diastolic dysfunction and strain
A hallmark of hypertrophic cardiomyopathy is diastolic dysfunction in the setting of intact systolic function. Although echocardiography can be used to indirectly measure diastolic function in humans, these parameters have not been translated into murine studies. Therefore, we used Langendorff perfusion to obtain hemodynamic pressure–volume relationships of hearts from A399S and WT control mice. There was no overall difference in negative dP/dt in A399S (mean −938 ± 166 mm Hg/s, n = 60 samples in 3 mice) compared with WT controls (mean −1,056 ± 397 mm Hg/s, n = 70 samples in 3 mice; p = 0.78) (Supplemental Figure 3), although 1 WT mouse had very decreased negative dP/dt (mean for 20 samples −2,022 ± 191 mm Hg/s). There was a large, but not statistically significant, increase in LV end-diastolic pressure in A399S mice (mean 21.0 ± 6.2 mm Hg, n = 45 samples in 3 mice) compared with WT mice (mean 5.7 ± 1.2 mm Hg, n = 45 samples in 3 mice; p = 0.016).
Cellular remodeling consistent with HCM in A399S mice
Echocardiography and CMR demonstrated morphological aberrations at the macroscopic level in A399S mice, consistent with HCM. We also performed histological analysis to correlate changes at the cellular level with macroscopic disease manifestations. Hematoxylin and eosin staining of heart sections confirmed the increase in interventricular septal diameter seen using imaging modalities (Figure 6A). The interventricular septal and free wall diameter measurements confirmed a significant increase in septal size relative to the free wall (median 1.45 mm, IQR: 1.44 to 1.75 mm, n = 3) compared with WT controls (median 0.96 mm, IQR: 0.72 to 1.00 mm, n = 3; p = 0.05) (Figures 6B and 6C). We assessed cell size in order to better understand the underlying septal thickening in A399S mice. Sarcolemma staining with wheat germ agglutinin revealed an increased average cross-sectional area of the septal myocytes from A399S mice (475 ± 80 μm2, n = 9 total samples from 3 mice) compared with myocytes from WT mice (272 ± 48 μm2, n = 9 total samples from 3 mice; p < 0.001). Whereas, average myocyte area from the LV free wall of A399S hearts remained unchanged (279 ± 41 μm2) compared with WT free wall myocyte area (293 ± 17 μm2; p = 0.509) (Figures 6D and 6F). These findings suggest that thickening of the interventricular septum is caused by localized hypertrophy of cardiomyocytes. Finally, analysis of magnified images of the interventricular septum (Figure 6G) revealed a greatly increased degree of myocardial fiber disarray and interstitial fibrosis (mean 8.9%, 95% confidence interval: 8.6% to 9.3%) in A399S hearts compared with WT hearts (mean 2.3%, 95% confidence interval 0.9% to 3.7%; p < 0.001) (Figure 6H). This pronounced level of myofiber disarray and fibrosis is often seen in the context of HCM.
Calcium handling and TT changes in A399S-PKI mice
To gain more insight into the possible mechanisms by which a JPH2 mutation causes HCM, we studied intracellular Ca2+ handling in ventricular myocytes isolated from WT and A399S mice. Isolated myocytes were paced at 1 Hz to obtain steady-state Ca2+ cycling (Figure 7A). The amplitude of the Ca2+ transients in myocytes from A399S mice (mean 1.95 ± 0.23, 24 total samples from 3 mice) was similar to those from WT mice (mean 1.75 ± 0.12, 26 total samples from 3 mice; p = 0.455) (Figure 7B). The SR Ca2+ content assessed using the caffeine dump protocol revealed no significant differences between myocytes from A399S mice (3.68 ± 0.41, n = 26 total samples from 3 mice) and WT mice (3.84 ± 0.97; n = 24 total samples from 3 mice; p = 0.88). On the other hand, there was a significantly higher SERCA2a activity consistent with faster Ca2+ reuptake into the SR in A399S myocytes, with a relative increase of SERCA2a activity in A399S cells compared with WT cells of mean 28 ± 10% (p = 0.006) (Figure 7C).
Next, the incidence of spontaneous SR Ca2+ release events known as Ca2+ sparks was assessed following the 1-Hz pacing train (Figure 7D). Quantification of the frequency of Ca2+ sparks revealed no significant differences comparing A399S mice (6.73 ± 0.84 sparks/100 μm/s, n = 20 total samples in 3 mice) and WT (6.13 ± 0.46 sparks/100 μm/s, n = 22 total samples in 3 mice; p = 0.54) mice (Figure 7E). Finally, we aimed to determine whether the A399S mutation in JPH2 altered the organization of TTs in isolated cardiomyocytes (Figure 7F). Compared with myocytes from WT mice, the TT power—a measure of TT regularity—was significantly reduced in cells from A399S mice (mean 15 ± 9% reduction; p = 0.097) (Figure 7G). These findings suggest that the genetic JPH2 variant might affect TT organization, which in turn might promote prohypertrophic growth in the ventricular septum.
Genetic basis of hypertrophic cardiomyopathy
HCM is a common genetic form of cardiomyopathy characterized by asymmetric cardiac enlargement with a reduction in ventricular chamber dimensions, hypertrophy of the interventricular septum, and diastolic dysfunction. Although more than 18 genes have been linked to inherited HCM, the most common defects are mutations in sarcomeric genes (18). Non-sarcomeric genes have also been linked to genetic HCM, including some genes involved in intracellular Ca2+ handling such as calreticulin 3 (CALR3), phospholamban (PLN), and also junctophilin-2 (JPH2) (9,11).
Because JPH2 mutations are a rare cause of HCM, and benign polymorphism has been reported in healthy individuals, we sought to establish whether the JPH2 variant A405S identified in the proband was causally linked to the disease phenotype. Transgenic mouse models have been used extensively to establish gene–disease causality and to gain deeper insights into the mechanistic pathways underlying cardiomyopathies (19). Therefore, we generated a novel HCM model caused by a JPH2 variant. Our studies revealed that A399S mice exhibited various features typically associated with HCM, including a hypertrophic interventricular septum, an increased LV mass, asymmetric LV hypertrophy with a reduced diastolic filling, and myofiber disarray. Because these findings in the mouse model mimicked clinical findings in the proband, a causal relationship between the JPH2 variant and HCM was established.
Highly sensitive cardiac imaging to uncover cardiomyopathy in a mouse model
Clinically, HCM is diagnosed on the basis of echocardiography parameters of LV hypertrophy in the absence of a clinically identifiable cause. However, due to the small size and rapid breathing of rodents, the detection of subtle asymmetric remodeling in mouse models is very challenging. Further, given the variable nature of the septal hypertrophy, traditional mouse echocardiography consisting of papillary-level transverse B-modes and corresponding M-modes may underappreciate certain configurations. Traditional long-axis views of the mouse heart provide poor visualization of the intraventricular septum, because the LV outflow tract is not well seen. Due to the ease of use of ultrasound and the relatively low cost, we found that devising an echocardiographic plane similar to the parasternal long axis in humans would prove beneficial in septal visualization in mice and thus improve identification of HCM. Indeed, this echocardiographic view of the mouse heart allowed us to see the full width of the septum and the LV outflow tract, and detect regional septal hypertrophy in the A399S mice (Figure 4). This human-like observation is quite unique among mouse models of HCM. It would be interesting to assess whether our novel imaging approach may also uncover local septal defects in other mouse models of HCM in which traditional echo protocols failed to uncover pathological findings (20).
CMR is the gold standard clinical test for cardiomyopathic disease that may appear normal on echocardiography, and can be used to establish a diagnosis in these false-negative cases (21). Further, CMR offers the possibility of more clearly defining cardiac anatomy and evaluating functional changes in myocardial contractility, stiffness, and strain, among other parameters, that are superior to traditional echocardiography. Here, we demonstrated that this imaging modality correlates well with echocardiography in the evaluation of the A399S mouse (Figure 5). Like the human patient, the A399S mice maintained normal systolic function but developed signs of diastolic dysfunction (22). These features of the myocardium are associated with clinical diastolic dysfunction and sudden cardiac death, especially among young HCM patients (23,24).
New insights into HCM pathogenesis obtained from our JPH2 mutant mouse model
Because the first HCM-associated genes were in genes encoding sarcomeric proteins, a final common pathway was proposed in which sarcomere disruption was the key pathogenic mechanism (25). Sarcomeric gene mutations disrupt the fine balance between intracellular Ca2+ cycling and mechanical force generation by the myofilaments. For example, many HCM-linked mutations in sarcomeric genes sensitize the myofilaments to greater Ca2+ adherence, thereby delaying SR Ca2+ reuptake and prolonging mechanical relaxation (26). In a recent study, Davis et al. (26) proposed a new tension-based model to predict which sarcomeric mutations cause HCM as compared with dilated cardiomyopathy. This model predicts that with HCM mutations, increased myofilament Ca2+ sensitization leads to a lower cytosolic Ca2+ requirement. Thus, Ca2+ leak typically seen in dilated cardiomyopathy may not necessarily occur in HCM pathogenesis.
The mechanism underlying hypertrophic remodeling associated with JPH2 mutations has remained elusive in part due to the lack of available animal models. We found that the A399S mutation in JPH2 affects the organization of the TT network, whereas there were no overt changes in systolic and diastolic SR Ca2+ handling. These results obtained in myocytes isolated from A399S mutant mice are corroborated by the previously mentioned Davis et al. (26) HCM model and correlated with the echocardiographic findings that ejection fractions were not altered in the mutant mice. However, contrary to the HCM model presented in the preceding text, SERCA2a activity was surprisingly enhanced in our mutants. This may be due to the specific nonsarcomeric nature of the A399S JPH2 mutation in contrast to the sarcomeric mutation model presented by Davis et al. (26). Because JPH2 is critical for TT maintenance, it is not surprising that a key cellular feature of the A399S mice is reduced TT regularity. This change in TTs may precipitate downstream events leading to HCM pathogenesis. The reduction in TT density may over time affect SR Ca2+ handling and affect excitation-contraction coupling, because prior studies have correlated a loss of TTs with the development of heart failure (27). Additional studies are required to determine whether and how JPH2 mutations linked to human HCM promote hypertrophic remodeling.
Our translational studies revealed that a novel mutation in JPH2— identified in a patient with HCM—also caused clear, unique features of HCM in the equivalent mutant mouse model, thereby validating a causal relationship between the JPH2 variants and HCM. The affected gene (JPH2) is not one of the canonical sarcomeric genes, and therefore underscores the heterogeneity in the molecular basis of this disease. Structural evaluation of cardiac function in the mutant mice required the development of novel imaging planes and techniques for mouse models of heritable cardiomyopathies will facilitate future rodent studies of the pathogenicity of novel gene mutants linked to human disease. These imaging approaches enabled us to uncover basal septal hypertrophy and diastolic dysfunction, signs of HCM that would have been likely missed on traditional echocardiographic approached used in mice. Future studies are warranted to determine what aspects of abnormal Ca2+ handling are amenable to therapeutic intervention to normalize cardiac function in animals or patients with JPH2-linked HCM.
COMPETENCY IN MEDICAL KNOWLEDGE: HCM is one of the most common heritable cardiovascular diseases and a common cause of sudden cardiac death in young individuals. The disease is often identified by imaging studies that show thickened walls of the heart muscle, usually most prominently in the ventricular septum.
TRANSLATIONAL OUTLOOK 1: The validation of a causal relationship between a mutation in the junctophilin-2 gene—a gene other than the typical sarcomeric genes linked to hypertrophic cardiomyopathy—underscores heterogeneity in the molecular basis of this disease.
TRANSLATIONAL OUTLOOK 2: The development of novel imaging planes and techniques for mouse models of heritable cardiomyopathies will facilitate future rodent studies of the pathogenicity of novel gene mutants linked to human disease.
The Genetically Engineered Mouse (GEM) Core at Baylor College of Medicine developed the mice used for breeding the PKI mice in this study. Mouse echocardiography was performed at the Mouse Phenotyping Core of Baylor College of Medicine, and mouse cardiac magnetic resonance imaging (CMR) was completed at the Small Animal Imaging Facility at Texas Children's Feigin Center. CMR analysis was completed at Texas Children's 3D analysis lab.
Supported by grants from the National Institute of Health and American Heart Association. Ms. Quick was funded by NIH training grant T32-HL007676, and American Heart Association 14PRE20490083. Dr. Landstrom is supported by a grant from the Pediatric and Congenital Electrophysiology Society. Dr. Wehrens is supported National Institutes of Health grants R01-HL089598, R01-HL091947, R01-HL117641, and R41-HL129570, and American Heart Association grant 13EIA14560061. Dr. Ackerman is a consultant for Biotronik, Boston Scientific, Gilead Sciences, Invitae, Medtronic, MyoKardia, St. Jude Medical, and Transgenomic; and receives royalties from Transgenomic. Intellectual property derived from Dr. Ackerman's research program resulted in license agreements in 2004 between Mayo Clinic Health Solutions (formerly Mayo Medical Ventures) and PGxHealth (formerly Genaissance Pharmaceuticals, now Transgenomic). Dr. Wehrens is a founding partner of Elex Biotech, a start-up company that developed drug molecules that target ryanodine receptors for the treatment of cardiac arrhythmia disorders. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
All authors attest they are in compliance with human studies committees and animal welfare regulations of the authors' institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC: Basic to Translational Science author instructions page.
- Abbreviations and Acronyms
- cardiac magnetic resonance imaging
- hypertrophic cardiomyopathy
- interquartile range
- junctophilin-2
- left ventricle/ventricular
- pseudo-knockin
- RyR2
- ryanodine receptor type 2
- sarcoplasmic reticulum
- transverse tubule
- wild-type
- Received September 27, 2016.
- Revision received October 5, 2016.
- Accepted November 1, 2016.
- 2017 The Authors
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- Go A.S.,
- Mozaffarian D.,
- Roger V.L.,
- et al.
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- ↵
- Beavers D.L.,
- Wang W.,
- Ather S.,
- et al.
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- Landstrom A.P.,
- Kellen C.A.,
- Dixit S.S.,
- et al.
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- ↵
- ↵
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- Respress J.L.,
- Wehrens X.H.
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- Garbino A.,
- van Oort R.J.,
- Dixit S.S.,
- Landstrom A.P.,
- Ackerman M.J.,
- Wehrens X.H.
- ↵
- ↵
- Seidman C.E.,
- Seidman J.G.
- ↵
- McCauley M.D.,
- Wehrens X.H.
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- Bang M.L.
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- Moon J.C.,
- Fisher N.G.,
- McKenna W.J.,
- Pennell D.J.
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- Davis J.,
- Davis L.C.,
- Correll R.N.,
- et al.
- ↵
- van Oort R.J.,
- Garbino A.,
- Wang W.,
- et al.


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It essential to know when products have been recalled and are no longer safe for use. They could cause serious injury to you or your loved ones. "Product Liability Law" are the legal rules for who is deemed responsible for defective or dangerous products. Companies often get a protective order in order to protect their confidentiality when they have a claim against a defective product. Confidentiality protects the manufacturer's reputation. However, in cases like product liability, protecting the confidentiality of these manufacturers may cause danger for the next consumers, causing the same harm as the previous consumers endured. California's Assembly Bill 899 serves to alleviate that. Its purpose is to prevent lawsuits from being settled confidentiality when it's about a defective product or environmental condition that poses danger to public health and safety. It's essential to know the ins and outs of this bill as well as common product defects.
The three main types of product defects are design, manufacturing, and inadequate warnings. Design defects are when the whole product line was designed in a way that may cause harm to the consumer. An example of this would be if a product line of toys had sharp edges causing children to get injured while using it. A manufacturing defect is when the manufacturing of a specific product, not the entire line, is flawed. For example, if you received a table with uneven legs, and it was only your table affected, then this is considered a manufacturing defect. The last form of a product defect is products with inadequate warnings. They are products that do not label or warn consumers of less-than-obvious risks that are posed by the use of their product. An example of this would be if christmas lights did not warn consumers of overheating if left on for long periods of time.
California's Assembly Bill 899 could have a huge impact on product liability law. One common example used for the argument for the bill is the situation with Goodyear tires. In terms of types of product defects, this was a design defect as it affected their whole line of tires. Between 1996 and 2003, their tires had failed when mounted on RVs. They were shown to have failed at high speeds. The tires were meant for use on delivery trucks, ones that ran at low stop-and-go speeds. The National Highway Traffic Safety Administration opened an examination in December 2017 after the court released the records. It was found that 1 death and 19 injuries were attributed to the tires. At least 41 lawsuits were filed against the company for these tires. The confidentiality allowed the company to hide this evidence for nearly 20 years. As a consumer, this bill could drastically change the legal environment. It may prevent many injuries and deaths from products.
When you buy a product you assume that it will work the way it should and it shouldn't cause you injury. This isn't always the case. Companies make mistakes or sometimes overlook defects in their product. It's unfair. If you or your family has been injured by a defective product then you deserve justice and compensation. You need someone with a lot of experience in product liability law and can fight for your rights. The legal team at Compass Law Group, PC will provide you with aggressive representation and personal attention to your needs.
You can call our office today at (800) 602-4010 or (310) 289-7126 for a free initial consultation. Or you can simply fill out our contact form.
No matter who the opposing party is, they can't outwork, outwit or outspend Compass Law Group, PC. We will do everything that is necessary to win the case, and we're here to help victims fight back against those who injured them.
Hiring the right personal injury attorney can often make the difference between getting the maximum settlement to account for your medical care, damages and lost wages or getting short changed or even having your case dismissed completely.
Have you been injured in an accident due to the negligence of others? Contact the Los Angeles personal injury attorneys at the Compass Law Group, PC because finding direction after an accident means having a great Compass on hand.


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It looks like you're new here. If you want to get involved, click one of these buttons!
Z-Community YouTube Channel Link
I would hope we can get a unlock method for the warp 7, its a good device and would be much better without the shackle! That being said will a method be released at all? And will we see nougat at all? If not, just another reason why we should unlock!
The Warp 7 is a boost mobile device. Boost and sprint dont unlock there devices so unless a really talented developer can figure a way out this device wont get unlocked.


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Honda Dealer Lake Worth FL
When you're ready to drive home a brand-new vehicle, you need look no further than our Honda dealer near Lake Worth, FL, to start your car-buying journey. If you're looking for a dealership that can help you experience a fun and convenient automotive experience, then keep in mind Braman Honda of Palm Beach.
Start Browsing Our Honda Inventory
Our inventory of new Honda vehicles is impressively plentiful. We have plenty of options, so you can bet there's one in there just for you and your lifestyle.
If you want a sedan, one that has both the fuel efficiency and that engine power to switch between work commutes and nights out, try a stylish Honda Civic. The slightly larger Honda Accord may also be a great choice if you'd prefer a midsize sedan.
Maybe you're looking for something bigger than that, however. The Honda Pilot has additional seating and great cargo space. It could be a good choice for a camping trip or just to take care of some light towing needs.
Our Used & Certified Pre-Owned Inventory
We're also home to a great selection high-quality used and certified pre-owned cars, trucks, and SUVs. These are good choices for drivers who would maybe prefer a vehicle that has undergone the majority of its initial depreciation.
Our certified pre-owned (CPO) cars are a particularly good choice, as they've undergone a multi-point manufacturer inspection and have qualified for extended factory warranty coverage.
Under a factory warranty, some of your repairs and necessary Honda parts replacements will be all covered. In the end, that equates to quite a bit of peace of mind.
Honda Financing near Lake Worth
At our Honda dealer near Lake Worth, FL, we have an in-house finance team members that are more than happy to hook you up with an auto loan fitting of your financial situation.
Your first step in securing a loan is to fill out an application here on our website. You can also fill out one in-person, if you'd prefer to come into the dealership first. In either case, once our financers have the information that they need, they can reach out to their network of lenders to get things rolling.
They have experience working with all different types of credit backgrounds. So, even if your standing isn't currently the greatest, they'll work to find a solution for you.
Leasing Options
Buying isn't the only option you'll have here at our Lake Worth area Honda dealership. You can also lease your Honda.
With a lease, you're not paying for the vehicle's full MSRP. Instead, you're paying monthly on the amount of depreciation it incurs during your lease period. For this reason, payments are a bit lower than normal.
That's not to mention, when you lease, you're only committed to the car for a term of a couple years are so. When the lease period is up, you can trade it in immediately for another brand-new car.
Service and Parts Department
When your vehicle needs it most, the service department at our Lake Worth area Honda dealer can provide the essential maintenance and repairs you need. In our state-of-the-art facility, our technicians work hard to provide everything from transmission services to brake-pad replacements to oil changes. Essentially, they run the full spectrum here.
Scheduling your next service appointment is easy. All you have to do is contact our team online or over the phone and we'll get your car into the shop as soon as possible.
Shop for Genuine Honda Parts
Working alongside our service team is the parts department for replacements and accessories. The benefit of buying these Genuine OEM parts, as opposed to aftermarket parts, is that they were made to fit your car and, in many cases, have warranty coverage.
Fill out an online form to order your parts. Once they come in, make an appointment and our technicians will install them so you don't have to worry about it.
Honda Specials & Incentives
At all times, we try to run a number of different deals here at our Honda dealership, so Lake Worth residents can save some money.
On one hand, we have specials and incentives on brand-new cars and great leasing options. On the other hand, we also have numerous service deals. With these coupons, you can save money on an oil change or on a tire rotation.
We're always running new and different deals. Check the specials page frequently to find one that you can apply to your next visit.
About Lake Worth FL
Lake Worth, which is (you guessed it) name for the bordering Lake Worth Lagoon, is well-known for its parks and many fishing hotspots. Snook Islands, with its boardwalk and kayak launch sites, is an excellent place for local anglers to cast out on a sunny day. There always seems to be something biting there.
Lake Osborne is another bountiful spot and may actually be a bit quieter if you take the boat out in the morning. If you need a new ride to load up your tacklebox in, our Honda dealer outside of Lake Worth ought to have what you need.
Visit Your Honda Dealer near Lake Worth FL
Taking the time to stop by Braman Honda of Palm Beach means you get experienced service that's focused on you. We're well-versed in the automotive process and are committed to making every step of it a fun one. When it comes to finding the right model, for instance, we listen to your needs and wants and pair you with a solid match.
Once you've got a selection that you think may be the one, you'll want to get behind the wheel here at our Lake Worth area Honda dealer. A test drive is the best way for you to know if that model really is perfect for you.
Contact our team today to schedule your next Honda test drive!


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The SentrySafe Digital Alarm Safe is equipped with hidden keypad with dual key entry and a loud audible alarm to provide modern advancements to protect against theft. The safe also features four large live-locking bolts, bolt-down hardware, a pry-resistant hinge bar, and third party verified protection from fire or flood for a powerful storage solution for any home office. In addition, the safe includes a multi-positional tray for flexible organization.
Watch this video for more details:
These safes are available for purchase for $299 in the SentrySafe store.
I'd like to give Mocha Man Style readers an opportunity to win a SentrySafe Alarm Safe. To enter the sweepstakes, answer the following question in the comments section (via FB or Disqus):
Have you ever owned a safe? If so, what prompted you to get it? If not, why not?
Additional Entries (These entries will be counted only after the required entry has been submitted. Leave a comment for each additional item you complete)
- Like Mocha Man Style on Facebook
- Like SentrySafe on Facebook
- Follow @mochamanstyle on and @SentrySafe on Twitter and share this tweet: Enter the @SentrySafe Alarm Safe Sweepstakes on @mochamanstyle http://bit.ly/1x9a62v (1 extra entry per tweet – 5 per day)
- Comment on any Mocha Man Style article (1 extra entry for each share– no limit)
- Share any via Twitter, Facebook, Pinterest, StumbleUpon, Google+ etc (1 extra entry for each share– no limit)
The sweepstakes starts on Wednesday, November 05, 2014 and ends on Monday, November 17, 2014 at 11:59 a.m. (EST), and is open to all Mocha Mocha Man Style readers, subscribers, and/or fans 18 years old and older in the continental U.S. and Canada. No purchase required. Relatives and employees of Goodall Family Media are not eligible to win. You are also ineligible if you've won a prize from this website within the past 30 days. One (1) winner will be chosen via Random.org and announced soon after the ending date. You must leave your contact information to collect your prize. If a winner does not respond within 3 days, a new winner will be chosen. Disclosure of Material Connection: I received compensation and/or one or more of the products or services mentioned above for free in the hope that I would mention it on my website. I am disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials in Advertising." All opinions are my own. Allow 3-6 weeks for giveaway fulfillment. Total prize value = $299. To see the winner, visit our Winners Page.
For more contests, giveaways, and sweepstakes, go to our Contests/SweepstakesPage and visit Mocha Dad


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New Skins in the Store
The following skins were released along with this patch.
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The following skins were released along with this patch, but were not available for purchase until Monday, February 7.
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- (Not available from the store, only as part of an external bundle) [ | ]
League of Legends V220.127.116.11
: Karma sends forth hidden blades from her fans, dealing magic damage to units in a cone in front of her.
- Mantra Bonus: In addition to dealing damage to enemies, Heavenly Wave will also heal allies in the cone based on a % of their missing life.
: Karma bonds an ally or enemy creating a beam between them. Allied anchors have increased movement speed and enemy anchors have reduced movement speed. Enemy units that come in contact with the beam take magic damage.
- Mantra Bonus: Karma strengthens the bond to double the effect of the movement speed modifier.
: Karma summons a protective shield that absorbs incoming damage.
- Mantra Bonus: In addition to casting the shield, energy radiates out from the shield dealing damage to enemy units around Karma's target.
- (Ultimate): Karma empowers her next ability to do an additional effect. Mantra is available at level 1 and does not require a skill point.
- (Innate): Karma gains increased Ability Power corresponding to her percentage of missing Health.
- no longer deals its bonus damage to towers.
- Range increased to 700 from 675.
- Now has a particle to indicate the amount of stacks.
- Fixed a tooltip bug that stated Ezreal was gaining 15% attack speed per stack instead of 10%.
- Fixed a bug where some of Ezreal's spells were displaying incorrect text on cast.
- Area of effect size and projectile speed increased slightly.
- Fixed a bug where was not properly drawing aggro from towers and monsters.
- General
- Fixed a bug where in some instances Jax would lose health while leveling.
- Base damage per dagger increased to 50/65/80 from 40/50/60.
- Ability power ratio per dagger reduced to 0.25 from 0.3.
- Attack damage scaling per dagger reduced to 50% from 55%.
- Fixed a bug where it sometimes wouldn't show a particle while active.
- Fixed a bug where it would occasionally scale off ability power instead of attack damage even though attack damage provided slightly more overall damage.
- Shield generation increased to 25 / 27.5 / 30% from 20 / 25 / 30%.
- Fixed a tooltip bug where it said it had 5% decay but it was actually 3%.
- Fixed a bug where could not deal damage to the same target within 1 second of the previous hit.
- Slow reduced to 20/25/30/35/40% from 28/36/44/52/60%.
- Slow duration reduced to 3 seconds from 4.
- : cooldown increased to 12 from 9.
- Stats:
- Health per level increased to 87 from 82.
- Base armor increased to 15.2 from 14.
- Armor per level increased to 3.8 from 3.2.
- Base damage increased to 60/90/120/150/180 from 40/70/100/130/160.
- Attack damage scaling increased to 80% from 60%.
- Basic heal reduced to 7.5% from 10%.
- Heal bonus when damaging Champions increased to 300% from 200%.
- Cooldown reduced to 8 seconds from 12/11/10/9/8.
- : cooldown reduced to 13/12/11/10/9 from 14/13/12/11/10.
- : armor reduction when furious changed to 15/17.5/20/22.5/25% from a flat 10/15/20/25/30.
- Fixed a bug where Renekton was gaining bonus attack damage while wounded.
- Fixed a bug where it could be dodged.
- General
- Removed from her tips.
- Base heal changed to 60/120/180/240/300 from 80/130/180/230/280.
- Ability power ratio reduced to 0.9 from 1.
- Armor buff increased to 20/35/50/65/80 from 15/20/25/30/35.
- Buff duration reduced to 4 seconds from 9.
- Passive: Now grants 10/15/20/25/30% increased movement speed until struck by a champion or turret.
- Active: Teemo gains double his passive movement speed for 4 seconds. This bonus is not lost on hit.
- Slow reduced to 40% from 50%.
- Slow duration reduced to 1 second from 1.5 seconds.
- : health cost reduced to 30/40/50/60/70 from 30/45/60/75/90.
- Fixed a bug where Vladimir in some instances would lose health when leveling.
- Cost increased to 475 from 435.
- Health regen per 5 seconds increased to 10 from 8.
- Cost increased to 475 from 435.
- Damage increased to 9 from 8.
- Cost increased to 475 from 435.
- Mana regen per 5 seconds increased to 5 from 4.
- : total cost increased to 2290 from 2090.
- : total cost increased to 3600 from 3400.
- now shows as a build option instead of .
- Fixed a bug with where the cost was inadvertedly increased and the mana granted lowered.
- Each unit now gains ability power and attack damage based on the caster's level, rather than each individual unit's level.
- Fixed a bug where it provided ability power whether or not you had the mastery.
- Fixed a bug where it was granting less ability power and attack damage than stated.
- Strength of Spirit (Season 2011 Mastery) Strength of Spirit: mana to health regeneration converted reduced by about 33% and clarified the tooltip to show that it was regeneration per 5 seconds.
- Meditation (Season 2011 Mastery) Meditation: mana regeneration per 5 seconds reduced to 1/2/3 from 1.66/3.33/5.
- Veteran's Scars (Season 2011 Mastery) Veteran's Scars: health reduced to 12/24/36/48 from 15/30/45/60.
- Clarity Runes reduced in effectiveness by about 33%.
- Quintessences of Fortitude reduced in effectiveness by about 20%.
- is now immune to disables.
- All Champions with mana had their base mana regeneration increased by 2.5 mana per 5 seconds and mana regeneration per 5 seconds per level increased by 0.2.
- Adjusted many champions' PVP.net attack, health, spell, and difficulty ratings.
- Removed many PVP.net tags (like heal, stun, and pet) and made the remaining tags more accurate.
- Updated many Champions' recommended item lists.
- Fixed several spells that did not preload properly, causing a delay the first time used in game.
Undocumented Changes
- The graphics for have been improved.
New Custom Game Bots
Removed Custom Game Bots
Custom Game Difficulty
- New Player and Easy difficulty setting replaced with a single Beginner difficulty.
In-Game Shop
- No longer opens via right click.
Patch Preview Video
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