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Organic anion transporter 1
The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene.[2][3][4] It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the kidneys. It plays a central role in renal organic anion transport. Along with OAT3, OAT1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys. From there, these substrates are transported into the lumen of the nephrons of the kidneys for excretion. OAT1 homologs have been identified in rats, mice, rabbits, pigs, flounders, and nematodes.[5]
OAT1 functions as organic anion exchanger. When the uptake of one molecule of an organic anion is transported into a cell by an OAT1 exchanger, one molecule of an endogenous dicarboxylic acid (such as glutarate, ketoglutarate, etc.) is simultaneously transported out of the cell.[5] As a result of the constant removal of endogenous dicarboxylic acid, OAT1-positive cells are at risk of depleting their supply of dicarboxylates. Once the supply of dicarboxylates is depleted, the OAT1 transporter can no longer function.
To prevent the loss of endogenous dicarboxylates, OAT1-positive cells also express a sodium-dicarboxylate cotransporter called NaDC3 that transports dicarboxylates back into the OAT1-positive cell. Sodium is required to drive this process. In the absence of a sodium gradient across the cell membrane, the NaDC3 cotransporter ceases to function, intra-cellular dicarboxylates are depleted, and the OAT1 transporter also grinds to a halt.[10]
The renal organic anion transporters OAT1, OAT3, OATP4C1, MDR1, MRP2, MRP4 and URAT1 are expressed in the S2 segment of the proximal convoluted tubules of the kidneys. OAT1, OAT3, and OATP4C1 transport small organic anions from the plasma into the S2 cells. MDR1, MRP2, MRP4 and URAT1 then transports these organic anions from the cytoplasm of the S2 cells into the lumen of the proximal convoluted tubules. These organic anions are then excreted in the urine.[5]
Known substrates of OAT1 include para-aminohippurate (PAH), dicarboxylates, prostaglandins, cyclic nucleotides, urate, folate, diuretics, ACE inhibitors, antiviral agents, beta-lactam antibiotics, antineoplastics, mycotoxins, sulfate conjugates, glucuronide conjugates, cysteine conjugates, ochratoxin A, NSAIDs, mercapturic acids and uremic toxins.[5]
Alterations in the expression and function of OAT1 play important roles in intra- and inter-individual variability of the therapeutic efficacy and the toxicity of many drugs. As a result, the activity of OAT1 must be under tight regulation so as to carry out their normal functions.[11] The regulation of OAT transport activity in response to various stimuli can occur at several levels such as transcription, translation, and posttranslational modification. Posttranslational regulation is of particular interest, because it usually happens within a very short period of time (minutes to hours) when the body has to deal with rapidly changing amounts of substances as a consequence of variable intake of drugs, fluids, or meals as well as metabolic activity.[11] Post-translational modification is a process where new functional group(s) are conjugated to the amino acid side chains in a target protein through reversible or irreversible biochemical reactions. The common modifications include glycosylation, phosphorylation, ubiquitination,[11] sulfation, methylation, acetylation, and hydroxylation.
Nucleoside analogs are a class of antiviral drugs that work by inhibiting viral nucleic acid synthesis. The nucleoside analogs acyclovir (ACV), zidovudine (AZT), didanosine (ddI), zalcitabine (ddC), lamivudine (3TC), stavudine (d4T), trifluridine,[12] cidofovir, adefovir,[13] and tenofovir (TDF) [14] are substrates of the OAT1 transporter. This may result in the buildup of these drugs in the proximal tubule cells. At high concentrations, these drugs inhibit DNA replication. This, in turn, may impair the function of these cells and may be the cause of antiviral induced Fanconi syndrome. The use of stavudine,[15] didenosine, abacavir, adefovir,[16] cidofovir [17] and tenofovir has been associated with Fanconi syndrome. Clinical features of tenofovir-induced Fanconi syndrome include glycosuria in the setting of normal serum glucose levels, phosphate wasting with hypophosphatemia, proteinuria (usually mild), acidosis, and hypokalemia, with or without acute renal failure.[18]
Mitochondrial inhibition[edit]
Since nucleoside analogs can build up in OAT1-positive cells and can inhibit mitochondrial replication, these drugs may lead to the depletion of mitochondria inside renal proximal tubules. Renal biopsies have demonstrated the depletion of tubule cell mitochondria among individuals receiving antiviral therapy with tenofovir. The remaining mitochondria were enlarged and dysmorphic.[19] In vitro the antiviral drugs didanosine and zidovudine are more potent inhibitors of mitochondrial DNA synthesis than tenofovir (ddI > AZT > TDF).[20] In its non-phosphorylated form, the drug acyclovir does not significantly inhibit mitochondrial DNA synthesis, unless the cell happens to be infected with a herpes virus.[citation needed]
Stavudine, zidovudine and indinavir (IDV) cause a decrease in mitochondrial respiration and an increase in mitochondrial mass in fat cells. Stavudine also causes severe mitochondrial DNA depletion. Combining zidovudine with stavudine does not increase the mitochondrial toxicity compared to stavudine alone. Both of these drugs must be phosphorylated by host enzymes before they become active. Zidovudine inhibits the phosphorylation of stavudine. This might reduce the toxicity of the combination. Using indinavir in combination with the other two drugs did not increase the toxicity of the combination. Indinavir is a protease inhibitor and works by a different mechanism than the other antiviral drugs. (d4T+AZT+IDV = d4T+AZT = d4T+IDV > AZT+IDV = AZT = IDV). All three of these drugs inhibit the expression of respiratory chain subunits (cytochrome c oxidase [CytOx]2 and CytOx4) in white fat cells but not brown fat cells.[21] Since stavudine and zidovudine are OAT1 substrates, they may have similar effects on proximal renal tubule cells as they do on fat cells.
Lamivudine has reverse chirality compared to didanosine, stavudine, zidovudine, and natural nucleosides. Mitochondrial DNA polymerase may not recognize it as a substrate. Lamivudine is not toxic to mitochondria in vivo.[22] Individuals who had been taking didanosine combined with stavudine exhibited improved mitochondrial function when they switched to lamivudine combined with tenofovir.[22][23]
Mitochondrial toxicity of OAT1 substrates:
- in vitro:
- d4T+AZT = d4T > AZT
- ddI > AZT > TDF > ACV
- in vivo
- d4T > AZT
- ddI > AZT > TDF
- d4T + ddI > 3TC + TDF
See also[edit]
- ^ Sekine T, Cha SH, Endou H (July 2000). "The multispecific organic anion transporter (OAT) family" (PDF). Pflügers Arch. 440 (3): 337–50. doi:10.1007/s004240000297. PMID 10954321.
- ^ Reid G, Wolff NA, Dautzenberg FM, Burckhardt G (Jan 1999). "Cloning of a human renal p-aminohippurate transporter, hROAT1". Kidney Blood Press Res. 21 (2–4): 233–7. doi:10.1159/000025863. PMID 9762842.
- ^ Lu R, Chan BS, Schuster VL (Mar 1999). "Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C". Am J Physiol. 276 (2 Pt 2): F295–303. doi:10.1152/ajprenal.1999.276.2.F295. PMID 9950961.
- ^ "Entrez Gene: SLC22A6 solute carrier family 22 (organic anion transporter), member 6".
- ^ a b c d Sekine T, Miyazaki H, Endou H (February 2006). "Molecular physiology of renal organic anion transporters". Am. J. Physiol. Renal Physiol. 290 (2): F251–61. doi:10.1152/ajprenal.00439.2004. PMID 16403838.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000197901 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024650 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Stellmer F, Keyser B, Burckhardt BC, et al. (July 2007). "3-Hydroxyglutaric acid is transported via the sodium-dependent dicarboxylate transporter NaDC3". J. Mol. Med. 85 (7): 763–70. doi:10.1007/s00109-007-0174-5. PMID 17356845.
- ^ a b c Xu D, Wang H, You G (2016). "Posttranslational Regulation of Organic Anion Transporters by Ubiquitination: Known and Novel". Med Res Rev. 36 (5): 964–79. doi:10.1002/med.21397. PMC 5147025. PMID 27291023.
- ^ Wada S, Tsuda M, Sekine T, Cha SH, Kimura M, Kanai Y, Endou H (September 2000). "Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs". J. Pharmacol. Exp. Ther. 294 (3): 844–9. PMID 10945832.
- ^ Ho ES, Lin DC, Mendel DB, Cihlar T (March 2000). "Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1". J. Am. Soc. Nephrol. 11 (3): 383–93. PMID 10703662.
- ^ Kohler JJ; Hosseini SH; Green E; Russ R; Santoianni R; Lewis w (April 2010). "OAT1 Knock-out Mice Define Its Role in Tenofovir Transport and Renal Proximal Tubular Mitochondrial Toxicity". FASEB J. 24 (1_MeetingAbstracts): Meeting abstracts, 1030.1.
- ^ Nelson M, Azwa A, Sokwala A, Harania RS, Stebbing J (2008). "Fanconi syndrome and lactic acidosis associated with stavudine and lamivudine therapy". AIDS. 22 (11): 1374–6. doi:10.1097/QAD.0b013e328303be50. PMID 18580619.
- ^ Ahmad M (2006). "Abacavir-induced reversible Fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome". J Postgrad Med. 52 (4): 296–7. PMID 17102551.
- ^ Vittecoq D, Dumitrescu L, Beaufils H, Deray G (August 1997). "Fanconi syndrome associated with cidofovir therapy". Antimicrob. Agents Chemother. 41 (8): 1846. doi:10.1128/AAC.41.8.1846. PMC 164022. PMID 9257778.
- ^ Atta MG, Fine DM (March 2009). "Editorial comment: tenofovir nephrotoxicity--the disconnect between clinical trials and real-world practice". AIDS Read. 19 (3): 118–9. PMID 19334329.
- ^ Herlitz LC, Mohan S, Stokes MB, Radhakrishnan J, D'Agati VD, Markowitz GS (September 2010). "Tenofovir nephrotoxicity: acute tubular necrosis with distinctive clinical, pathological, and mitochondrial abnormalities". Kidney Int. 78 (11): 1171–1177. doi:10.1038/ki.2010.318. PMID 20811330.
- ^ Vidal F, Domingo JC, Guallar J, et al. (November 2006). "In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells". Antimicrob. Agents Chemother. 50 (11): 3824–32. doi:10.1128/AAC.00437-06. PMC 1635212. PMID 16940060.
- ^ Viengchareun S, Caron M, Auclair M, et al. (2007). "Mitochondrial toxicity of indinavir, stavudine and zidovudine involves multiple cellular targets in white and brown adipocytes". Antivir. Ther. (Lond.). 12 (6): 919–29. PMID 17926646.
- ^ a b Honkoop P, de Man RA, Scholte HR, Zondervan PE, Van Den Berg JW, Rademakers LH, et al. (1997). "Effect of lamivudine on morphology and function of mitochondria in patients with chronic hepatitis B.". Hepatology. 26 (1): 211–5. doi:10.1002/hep.510260128. PMID 9214472.
- ^ Ananworanich J, Nuesch R, Côté HC, Kerr SJ, Hill A, Jupimai T, et al. (2008). "Changes in metabolic toxicity after switching from stavudine/didanosine to tenofovir/lamivudine--a Staccato trial substudy". J Antimicrob Chemother. 61 (6): 1340–3. doi:10.1093/jac/dkn097. PMID 18339636.
Further reading[edit]
- Hosoyamada M, Sekine T, Kanai Y, Endou H (1999). "Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney". Am. J. Physiol. 276 (1 Pt 2): F122–8. doi:10.1152/ajprenal.1999.276.1.F122. PMID 9887087.
- Race JE, Grassl SM, Williams WJ, Holtzman EJ (1999). "Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)". Biochem. Biophys. Res. Commun. 255 (2): 508–14. doi:10.1006/bbrc.1998.9978. PMID 10049739.
- Cihlar T, Lin DC, Pritchard JB, et al. (1999). "The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1". Mol. Pharmacol. 56 (3): 570–80. doi:10.1124/mol.56.3.570. PMID 10462545.
- Bahn A, Prawitt D, Buttler D, et al. (2000). "Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene". Biochem. Biophys. Res. Commun. 275 (2): 623–30. doi:10.1006/bbrc.2000.3230. PMID 10964714.
- Babu E, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters mediate the transport of tetracycline". Jpn. J. Pharmacol. 88 (1): 69–76. doi:10.1254/jjp.88.69. PMID 11855680.
- Burckhardt BC, Brai S, Wallis S, et al. (2003). "Transport of cimetidine by flounder and human renal organic anion transporter 1". Am. J. Physiol. Renal Physiol. 284 (3): F503–9. doi:10.1152/ajprenal.00290.2002. PMID 12429554.
- Ichida K, Hosoyamada M, Kimura H, et al. (2004). "Urate transport via human PAH transporter hOAT1 and its gene structure". Kidney Int. 63 (1): 143–55. doi:10.1046/j.1523-1755.2003.00710.x. PMID 12472777.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wolff NA, Thies K, Kuhnke N, et al. (2004). "Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization". J. Am. Soc. Nephrol. 14 (8): 1959–68. doi:10.1097/01.ASN.0000079040.55124.25. PMID 12874449.
- Sauvant C, Hesse D, Holzinger H, et al. (2004). "Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells". Am. J. Physiol. Renal Physiol. 286 (4): F774–83. doi:10.1152/ajprenal.00326.2003. PMID 14644751.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Tanaka K, Xu W, Zhou F, You G (2004). "Role of glycosylation in the organic anion transporter OAT1". J. Biol. Chem. 279 (15): 14961–6. doi:10.1074/jbc.M400197200. PMID 14749323.
- Sakurai Y, Motohashi H, Ueo H, et al. (2004). "Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases". Pharm. Res. 21 (1): 61–7. doi:10.1023/B:PHAM.0000012153.71993.cb. hdl:2433/144752. PMID 14984259.
- Bahn A, Ebbinghaus C, Ebbinghaus D, et al. (2005). "Expression studies and functional characterization of renal human organic anion transporter 1 isoforms". Drug Metab. Dispos. 32 (4): 424–30. doi:10.1124/dmd.32.4.424. PMID 15039295.
- Hong M, Zhou F, You G (2004). "Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1". J. Biol. Chem. 279 (30): 31478–82. doi:10.1074/jbc.M404686200. PMID 15145940.
- Zalups RK, Aslamkhan AG, Ahmad S (2005). "Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury". Kidney Int. 66 (1): 251–61. doi:10.1111/j.1523-1755.2004.00726.x. PMID 15200431.
- Zalups RK, Ahmad S (2004). "Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1". J. Am. Soc. Nephrol. 15 (8): 2023–31. doi:10.1097/01.ASN.0000135115.63412.A9. PMID 15284288.
- Fujita T, Brown C, Carlson EJ, et al. (2005). "Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1)". Pharmacogenet. Genomics. 15 (4): 201–9. doi:10.1097/01213011-200504000-00003. PMID 15864112.


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Carla Esparza Brands Claudia Gadelha a 'Cheater', Accuses Her of Greasing at UFC 225
Carla Esparza was confident during UFC 225 that her opponent Claudia Gadelha was greasing and after watching the replay at home, she's more convinced than ever that her opponent was cheating.
Esparza lost a razor close decision to Gadelha last Saturday night in a back and forth battle between two strawweight contenders with years of history between them.
As heartbreaking as the loss was considering Esparza truly believes she won, the more upsetting incident came during the fight when the former UFC champion was concerned that Gadelha had somehow greased her body to prevent takedowns and submissions.
"This is not to say anything or give an excuse why I lost because I felt like I won, but Claudia was greasing during the fight. She's a cheater. I've always kind of felt she was a dirty fighter and this was my first time being in the cage with somebody that's greasing," Esparza explained when speaking about the fight at UFC 225. "I was pretty upset, especially after the decision went the way it did. Rewatching the first round, going for her legs and my hands are just slipping right off. Going for armbars and I remember in the fight thinking 'what the hell, my arms are just slipping right off her arms' trying to set up these armbars. It was getting a little bit frustrating. I contemplated talking to the referee after the second round but I really didn't know how to go about it.
"That's my only regret. I wish I would have spoken up about that during the fight. "There's no question in my mind that she was greasing. Having grabbed onto her legs and having her slip right off. People get sweaty and I know the difference. I've been wrestling for 15 years. I'm not stupid. She's just flat out a cheater and that's just sad that she would do something like that."
The act of greasing in mixed martial arts can happen by numerous methods including bathing in certain substances that make the skin slicker once sweat starts flowing from the pores.
Officials will typically check athletes before they go into the Octagon and if they believe a part of the body has some kind of extra substance on it, they can demand a towel to wipe down the area before allowing the fight to continue.
Of course while there are some preventative measures in place, Esparza is far from the first fighter to believe an opponent has greased up in some way before the fight to gain a competitive advantage.
Esparza was already convinced on the night of the fight but when she actually went back and watched the three round battle, she knew beyond a shadow of a doubt that Gadelha had something on her arms and legs.
"When I was grabbing her arms and my arms were just kind of like sliding right down, I was like 'this is bulls–t'. I was almost like thinking should I tell the ref right now? That was when it really sunk into me," Esparza explained.
"I rewatched the first round even more, I watched it twice, because I wanted to have no doubt in my mind. I didn't have any doubt in my mind during the fight but after I had to be sure. The only single leg that I finished was when I was wrapping around so much that I was touching my own elbows. If I had just been gripping my hands, my arms would have slid right off. I've hit a million single legs and double legs over the years and I've never felt like that before."
Unfortunately because there's no real way to prove what happened after the fact, Esparza doesn't believe there's anyway to appeal the decision.
More than anything, Esparza would just like the chance to avenge the loss with hopes that the UFC will offer her a rematch against Gadelha.
"I've had my opinions of her in the past and maybe her being a cheater or not with other things, but now I know with 100-percent fact. You cannot like somebody as a person and still respect them as an athlete but now this takes away all your integrity as an athlete that you have to go out and cheat. It just shows me that she was afraid of me. If she thought that she could beat me, she wouldn't need to cheat," Esparza said.
"I would love to rematch her. Regardless of what happened in the fight, I was happy I got to punch her in the face and give her as much damage as I did in the fight. I didn't take too much damage. This was probably the least damage I've taken in a fight in a long time. I would love to rematch her and hopefully have my hand raised. That's the way I felt it should have went. I'd fight her again next week if I could."

subset: commoncrawl


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Whether donating money to local charitable organizations
or to national charities in the form of grants, the focus is always
the same – children. By making a difference now in their
formative years, their true potential for achievement will be enhanced
dramatically. Through educational programs, engaging arts & cultural
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today to fulfill their dreams of tomorrow.


text: Although the role of keywords in SEO has changed greatly since the early days of search, with the evolution of long-tail keywords and natural language search, the humble keyword is still one of the fundamental building blocks of search optimization, and an important Google ranking signal. Getting screen time from visitors to a site depends on how well you know who you're trying to target and how much you can tickle them. The technology used on your website can sometimes prevent Google from being able to find your content. Rich media (Flash, JavaScript, etc.) can lead to Google not being able to crawl through navigation, or not see content embedded in a webpage. Many webmasters only want to rank well for single words (rather than chains of words).


text:
Has this ever happened to you? The office door swings open and in walks your manager. Things have changed. The target for a new product you're about to pitch is no longer the usual suspects – it's now the C-Suite.
There are lots of good reasons why this conversation could take place. For one of our clients, this change in strategy was because they were moving from a product-focused sales approach to selling more valuable (and more complex) solutions. Due to the increase in purchase price, the decision-maker also rose – from business heads to CFO's and CEO's. We're also working with clients where their senior executives want to augment and reinforce the day-to-day efforts of their account managers to build relationships with C-Suite executives at their major clients. In market downturns, we've seen also seen companies quickly switch the target for new product launches to top-level decision-makers, where there's more control over budgets and buying-power.
Whether your approach to the C-Suite is planned or opportunistic, the most important thought to keep in mind is preparation. Life at the top is indeed different. To be successful in your approach, a little planning will go a long way. In this race, it will definitely be more rewarding to be a well-prepared tortoise, not a "shoot from the hip" hare. Before you pick up the phone or fire-off an email to a C-Level prospect, know the do's and don'ts of effective communication with the C-Suite, so your outreach achieves the results you want.
Our CEO recently received an email from a new company wanting our business. This email started off badly – it went into the junk folder. This got me thinking about all the Do's and Don'ts of reaching out to the C-Suite. The mistakes this company made are easy to avoid, but communication that works effectively in the C-Suite takes some effort.
Do Really KNOW your customer
One size does not fit all when it comes to the C-Suite. Whether you're calling on a CEO, CFO or CMO, do your research! You need to inform yourself about their company because you need to communicate why your solution will be valuable to them in their terms. Read-up on recent company news. What are some of their growth, hiring or restructuring initiatives (budgets for new investments are often aligned with these initiatives). Use the words they use (e.g. do they refer to customers or clients, do they refer to their salespeople as reps or advisors or relationship managers?). You should also have a little insight into the person you're targeting so you can relate to them on a human level. For example, if they've recently had a promotion, congratulate them. Find out where they went to college or an authentic, common thread to use as a conversation starter. Hubspot suggests asking a question about a recent company announcement or industry change. (Hint: RelPro helps you quickly accomplish this research – it saves you time!)
Don't presume!
The email our CEO received mentioned several concerns that would keep any CEO up at night, but the wording was so generic to all CEOs. The email stated that the company knew what C-Suite concerns would be, because – hey – they've got a C-Suite, too! Not much thought went into personalizing the message here!
Don't infer the email address – get a reliable source of quality contact data
C-Suite executives often have an email format different than the general corporate standard – it's the most closely guarded email address in the firm! Inferring such emails would lead to a high bounce rate resulting in a bad reputation for your IP address. What else does it do when you try to guess email addresses? Your emails end up in the junk folder! There's now a good chance that the C-Suite executive never even saw your email, and if they did take the trouble to find it in their junk folder, you've already lost credibility.
Do guide yourself with a clear goal
Once you're on the phone or in the office with your targeted executive, you'll have a very limited amount of time to cover a lot of ground. Ago Clutyens, EMEA Practice Director at the RAIN Group, suggests planning your conversation like you would a trip: What's your destination? What are the 'must sees' along the way? "Rather than drafting a bullet-point outline of topics for the meeting, think about what you'd like to accomplish," Clutyens advises. "Starting-off well (preparation) and planning the major points on your journey will help ensure you address your agenda as well as theirs."
In their Harvard Business Review article, "Salespeople Need a Strategy for Selling to CEO's", Frank Cespedes, Jay Galeota and Michael Wong suggest being ready with examples or case studies that demonstrate your awareness of the customer's business context. "And then you must be willing to go with the flow if the customer has other topics in mind. It's about active listening: be better prepared and more granular in your questions."
Hubspot agrees, "Your agenda should be able to accommodate topics you didn't anticipate. You should also be able to condense it: You never know when the executive will need to end the meeting earlier than scheduled."
Geoffrey James, a contributing editor at Inc, recommends coming to grips with the executive's business agenda, "what he or she needs to accomplish organizationally. Then use your contacts in the firm and your own business acumen to understand the exec's "personal agenda"–likely career goals, the job that he or she is angling for, and so forth."
Don't waste their time
As you know, the C-Suite executives have plenty on their plate. CEO's constantly juggle priorities. Their calendars take the phrase "time-poor" to a new level. Anyone who wastes their time quickly goes down in flames. In the email to our CEO, the company presented a solution – but their call-to-action didn't lead to a concise marketing message. Instead, to understand their benefit, they wanted their C-Suite readers to click on a link and watch a video, because "it's short and funny!"
Do follow-up's – ALWAYS
Perhaps the most important action a sales person can take is to follow up quickly after a meeting or conversation. It's valuable after every sales interaction, but it's vital with C-Suite contacts. Cespedes, Galeota and Wong think "it's at least as important as what happens during the meeting." Geoffrey James says to always close with a next step.
Don't forget to dust off your patience. You probably won't hear back immediately from any C-Suite contact, due to their busy schedules and intense focus on their top priorities. Hubspot suggests making 5 contacts over a 45-day period. However, you will dramatically improve your chances of achieving the outcome you want if you do your homework, demonstrate the value your solution brings to their challenges and show respect for their situation and time constraints.
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In a TED talk, novelist Chimamanda Adichie tells her story of growing up in middle-class Nigeria and confronting her own stereotypes. She talks about how the "stories" she grew up with impacted her perception of the world and how she's seen similar biases in people and cultures around the world.
Her story challenged me to expand my own story collection and examine my stereotypes. Too often, the media bombards us with a single perspective that begins to form a picture of a country or people group that is lopsided. Recently my church launched an initiative called "Greater Things." Part of this initiative is to launch the Hope Partnership to partner our church with four organizations that are targeting the issues of HIV/AIDS and the plight of orphans and widows in the countries of Zambia, Malawi, and Kenya. This is a beautiful and admirable goal and I'm excited to see the impact it has.
Yet, as with many other stories of Africa, this continues to reinforce my image of that continent as one plagued with poverty, disease, and destitution. Yet there is so much more to Africa than just those in dire straits!
In fact, I'm challenged by my public school education and its focus on an Americentric/Eurocentric take on world history. As my wife and I homeschool our kids, we're purposefully seeking out resources and curriculum that provide a more balanced view of history and the events that have shaped the world.
Chimamanda's talk is engaging, humorous, and often convicting. Enjoy!


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The Scramble Scores Again!
I am a long-time fan of the Six O'Clock Scramble... I've used Aviva Goldfarb's menu service for many years and both her weekly system and the recipes themselves are always top notch. First, the system... she plans your weekly menus for you, including side dishes for each meal, and provides the shopping list broken down by the areas in the store where you will find things (i.e produce, refrigerated items, etc.). The menus are arranged seasonally to take advantage of fresh produce available in warm months and give you more comfort food to enjoy in colder months. The system works really well for me. It's basically point and shoot... I take the shopping list, buy the groceries, make the food... that whole logistical/decision-making side is streamlined. So easy! Then, the recipes... I love Aviva's recipes. There is a nice variety of nutritious, simple, tasty meals every week. If you are a meat and potatoes family, this will not work for you. But it's exactly how I like to eat... many vegetarian options, frequent chicken and fish recipes, occasional red meat. It works very well for me and my family's preferences. In addition, she provides the side dishes and tells you when to make them while you're cooking the main dish so everything is done at the same time. Her recipes are pretty foolproof, and that's saying something for me. I have made hundreds, maybe thousands(!) of Aviva's recipes over the 12+ years I have subscribed to her service, and they are, nearly without fail, delicious! Examples from this cookbook... I made the Week 1 Winter recipes this past week. • Baked chicken with maple butter glaze – not everyone in my family likes chicken on the bone so I hesitated a little, but this recipe worked out really well. The chicken is so juicy and flavorful and this dish is extremely easy to make! • Succulent salmon with caramelized onions – I so appreciate how Aviva has managed to bring delicious fish dishes regularly into my family's diet… this recipe is another excellent salmon dish, so healthful. The side dish for this recipe, farro, is another new addition for us… sort of like couscous, we've come to really enjoy exploring new foods with these recipes. • Pesto vegetable soup with tofu – Delish comfort food and you can use chicken instead of tofu, but it's really good with the tofu. And garlic toast! How can you go wrong with that! • Spicy slow-cooked Indian Dal – I made this in the crockpot last Sunday and the house smelled so good all day. This delicious lentil stew was a hit with my kids and I continued to enjoy leftovers for lunch during the work week. • Vegetarian enchiladas verdes – another winner with my kids. The cremini mushrooms in this dish taste like meat… so flavorful. I love that Aviva can get my kids to eat veggies regularly… these enchiladas are filled with spinach, but so delicious that no one said a thing while they were stuffing them down! This was a typical week of Scramble cooking… the planning done for me, the shopping streamlined, the recipes easy and nutritious, and happy tummies for my family. I have two kids… one picky and one adventurous. I can usually pull out ingredients (plain chicken, etc.) to make the picky one happy, but he tries everything and I figure some day he'll develop a wider palate. I can honestly say that Aviva taught me to cook... her recipes have made it possible for me to feed my family healthy meals day in and day out for over a decade. They save me time and money... my shopping is streamlined, I rarely go to the store more than once a week, and we usually eat at home because I have something to cook... no need to go out to restaurants at the last minute. I also have leftovers to take to work for lunch nearly every day. This cookbook is a great addition to the Scramble repertoire. If you want a variety of tasty and nutritious recipes and an easy system for getting them on your table, you will not be disappointed!


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Today I came across a cool keyword in a Sass file. It's called '!default'. There was a variable declaration and then !default after it e.g.
$foo: 20px !default;
So, I decided to fine out what exactly it means. !default means the variable will be set if it has not already been set. This way, you can declare project specific values of a variable first and then add the defaults after it.
- A Sass `!default` use case. https://robots.thoughtbot.com/sass-default


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Swan chair - Dorset
High-quality reproduction of Arne Jacobsen's design
Discover the reedition of the mythical and timeless Swan Chair, initially designed to furnish the lobby and the reception of the Royal Hotel in Copenhagen. Considered innovative at the time, it has a moulded shell of synthetic resin with a layer of cold foam covering the shell. This Scandinavian design has distinctive curves that create a cocoon for the body. That it has been passed on from generation to generation shows that the Swan Chair is here to stay. Its vintage style will forever be sensational.
- Depth 23"
- Width 29"
- Back height 31"
- Seat height 18"


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Ottawa-Gatineau > Profile >
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Biediger et al v. Quinnipiac Univ
Filing 2
MOTION for Temporary Restraining Order & Preliminary Injunction (Responses due by 5/7/2009, ) by L. R., Robin Lamott Sparks, Stephanie Biediger, Kayla Lawler, Erin Overdevest, Kristen Corinaldesi, Lesley Riker. (Attachments: # 1 Memorandum in Support, # 2 Text of Proposed Order -Temporary Restraining Order, # 3 Text of Proposed Order - Preliminary Injuction)(Torres, K.)
Disclaimer: Justia Dockets & Filings provides public litigation records from the federal appellate and district courts. These filings and docket sheets should not be considered findings of fact or liability, nor do they necessarily reflect the view of Justia.


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146 Welding Students!
by Mahany Welding Supply on September 28, 2012
As of September 28th, 2012 there are currently 146 students enrolled in the RocAFC Fall welding classes! 94 students attend class on a weekly basis for the RocAFC Welding Career Program, MIG Night Course, Stick Night Course and collegiate classes through RIT and MCC. There are still plenty of available classes through October and November so be sure to signup online and come weld with Mahany Welding Supply and the Rochester Arc & Flame Center! Click the following picture to view our Fall welding students:Read More »
RocAFC in the Rochester Business Journal
by Mahany Welding Supply on January 06, 2012
Click the thumbnail to view RocAFC's article in the Rochester Business Journal:Read More »
RocAFC Grand Opening in the Democrat and Chronicle
by Mahany Welding Supply on January 04, 2012
The Grand Opening for RocAFC was included in this morning's edition of the Democrat and Chronicle. Click on the thumbnail to read the online version:Read More »
RocAFC January Construction Update
by Mahany Welding Supply on January 03, 2012
With the building construction complete, RocAFC staff and volunteers are now preparing for the Grand Opening on January 7th. Make sure to stop by anytime from 10am-5pm at 125 Fedex Way, Rochester, New York. We hope to see you all there!Read More »
2012 Winter & Spring Welding Classes!
by Mahany Welding Supply on November 09, 2011
Class signup available online here or signup at Rochester Arc & Flame Center (ROCAFC). Please note, all classes after January 1st, 2011 will take place at ROCAFC which is located next to Mahany's at 125 Fed Ex Way, Rochester, NY.Read More »
Rochester Arc & Flame Center's Website
by Mahany Welding Supply on October 31, 2011
The Rochester Arc & Flame Center's website is here! Signup for classes online before they fill up!Read More »


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Olympic National Park, located in the state of Washington was founded by U.S. President Theodore Roosevelt in 1909, originally called Mount Olympus National Monument, then later changed when President Franklin Roosevelt claimed it a national park. It is an International Biosphere Reserve with four basic regions: the Pacific coastline, alpine areas, the west side temperate rainforest […]
Posts Tagged 'things to do in port angeles'
Top Things to Do at Olympic National Park
Posted by Leland on September 11th, 2015
Summer Events in Port Angeles, WA
Posted by andreas on May 5th, 2015
Port Angeles in the Olympic Peninsula is always teeming with awesome events that come in many forms. Foodies, music lovers, bird watchers, and other hobbyists will surely find local shops and organizers that cater to their interests. The staff at George Washington Inn share the following calendar of events, so make sure to stop by in […]


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Warfare 09
Whilst some shows seem to have fallen away slightly over recent years, Warfare at the Rivermead seems to get better every year. once upon a time, it seemed the main hall was sufficient to house the trade and display games, the gym was spaciously accommodating competitions. Now the show proper takes the main Hall and half the gym, the competitions fill out the rest of the space, there is even a strange room right down the back with Warhammer stuff in it. The ancients competitions have always been very well supported, and with a good range of trade and games, this is an excellent event which fully demonstrates that the way to succeed is to stick to that traditional balance, mixing plenty of stuff to join in with and try out with the shopping and competitions.
(Phil Sabin/Eric Cruttenden's Lost Battles presentation of Cunaxa)
The Society of Ancients followed a now regular formula at this show ... a large 25mm Lost Battles participation game with author Philip Sabin on the Saturday, swapping to a Medieval Warfare try-out game with David Edwards and Kevin Large on the Sunday.
Cunaxa provided one of those classic 'Lost Battles' challenges ... how to beat a (significantly) cavalry army with hoplites - but at the same time (given the colossal advantage the hoplites enjoy, and for which they pay), how to win a game in which you can hardly afford to lose any soldiers? I know - during a quieter session, I played the rebels ... I won the battle itself, but narrowly lost on the game score. That probably will have meant a long and testing journey back to the sea ...(the Neil Thomas Ancient and Medieval Wargaming table)
Out and about, a number of things caught my eye ... A very legible layout of Antietam. Antietam is one of the many 'visitor friendly' battlefield in the US, and it was interesting to relate what was shown on the table to walking the field ... especially 'Burnside's bridge' .... I really must dig out those videos I filmed on the 2003 Historicon tour ...
(Antietam - Burnside's bridge)
That said, this blog is mostly about ancients.
So I was very interested to see, just across the aisle from us, the Malvern guys and their Arthurian themed 28mm Armati game. Armati is like that: just when you think you've met everyone that regularly plays the game, up pop some more. Of course, though the Armati League, I'm most used to seeing the game played in 15mm, and found, doing a vast Boudicca's Revolt game for English Heritage's History in Action, 28mm a difficult scale to get satisfactory visual results with. So it seemed strangely unusual to see the game in the larger scale. Kudos to them for putting it on, of course, and it's always nice to see Armati at a show.(the Malvern Armati game)
There was much more to see of course (see the banner collage at the top of the page) - doubtless most of the glossy space will go to the colossal Blenheim game in the main hall. Actually, I took some photos too, because it was impressive in its own way. If all static display games were as good, I might have more time for them. Mostly, these days, they seem to be sponsored by the people that make the figures, of course ...
An excellent weekend. Many thanks to all the people who dropped by and the volunteers who made the Society stand a relaxing place to be based. Although we only ever had three or four people on hand at any one time, I made 10 member/volunteers who rotated their way on and off the stand or game over the weekend. Volunteering like that is what make the Society of Ancients work well. If reading these blog entries makes you want to volunteer, contact the Secretary or put a comment on the blog (I'll get back to you and we should be able to fit you in ...)...(flying a banner on the Society stand)
Wednesday, December 30, 2009
Reading, 21st-22nd November
Posted by SoA Shows North at 11:33 AM
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21364 Cypress Hammock Dr #1j, Boca Raton, FL - $219,900
This spacious TOTALLY FURNISHED townhouse has 2 bedrooms, each with a full bathroom. The large Florida Room has sliders which provide sweeping views of the golf couse. The eat-in kitchen overlooks the beautifully landscaped private front entrance patio. The washer, dryer and the half bath are located on the first floor. The open and spacious living room is perfect for entertaining large groups of friends and family . The Cypresses of Boca Lago is a 55+ community in a highly desirable area and offers a manned gate, 2 pools a clubhouse and plenty of guest parking. The location and views are some of the best in Boca Raton, just moments away from the best restuarants, shopping and cultural events. The BOCA LAGO COUNTRY CLUB membership is available but not mandatory.
Cable, 3-Phase Electric, Public Sewer, Public Water
Assigned, Guest, Vehicle Restrictions, No Motorcycle
Foyer, W/D Hookup, Walk-in Closet, Stack Bedrooms, Custom Mirror
Dishwasher, Disposal, Dryer, Microwave, Range - Electric, Refrigerator, Smoke Detector, Washer, Water Heater - Elec, Hookup
|Status Changed from New to Backup
All listings featuring the BMLS logo are provided by Beaches MLS Inc. Copyright 2020 Beaches MLS. This information is not verified for authenticity or accuracy and is not guaranteed.
© 2020 Beaches Multiple Listing Service, Inc. All rights reserved.
Listing information last updated on June 3rd, 2020 at 6:02am EDT.


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Developing sustainable, competitive and inclusive metropolitan areas is key to improving the quality of life for urban citizens.
By working together through advocacy actions, UITP is pleased to announce the signing of an MoU with Metropolis, the World Association of the Major Metropolises. By combining efforts, the global reach of both UITP and Metropolis will allow for cooperation in the field of sustainable mobility by exchanging information on urban transportation policies, planning, management and operations.
Working with key decision makers in our cities is vital to advancing urban life and this agreement will allow UITP and Metropolis to advance on advocacy and outreach inititiatives such as the Mobility Champions Community.
As an official supporting partner of the Mobility Champions Community, Metropolis and its members understand the need to advance transport and mobility issues by promoting the health, social inclusion/gender, innovation and economic benefits of sustainable mobility in metropolitan areas.
Mobility is at the heart of sound structured metropolitan spaces.
"Mobility is at the heart of sound structured metropolitan spaces. This MoU will strengthen the work both organisations are carrying out in other to improve the quality of life of citizens", said Octavi De La Varga, Secretary General, Metropolis.
Read more about our collaboration in the official press release!


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Put your memory and reflexes to a test in Alienanza, the fun mind-bending space game! How long can you keep track of crazy aliens from outer space? Uh-oh, time is running out and the pace is picking up really fast! Boast your score to friends and challenge them to do better!
Related Games
Cut The Rope
Mar 27, 2018 359 views
Cut the Rope 2
Mar 27, 2018 295 views


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WHAM-O Hula Hoop Flexi Skip
WHAM-O Hula Hoop Flexi Skip
Product Description
The Flexi Skip appears to be a simple toy, but it requires coordination and concentration to keep it going!
- Features: Indoor, Outdoor
- Measurements: 30 Length/Inches
- Base Material: 100% Plastic
- Care: Wipe Clean
- Country of Origin: Imported
Shipping & Returns
Convenient Shipping Options
Not available at your store? We can ship to you directly or to your favorite JCP location.
Easy Returns
Shop with confidence. Read our full, common sense


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VISUG Announces 2 Events And Their New Website
The guys at the Belgian Visual Studio User Group (VISUG) have been working very hard on their new website and they must be happy that they have it online now. Good work, guys! Besides that, they also announce 2 upcoming user group events:
Discussion on Enterprise Exception Handling and Logging
Presented by: Panel of specialists
On: 11 December 2006
This is a session where you (yes, you!) can discuss exception handling and logging in enterprise applications. Bring your tips and tricks, problems and exception handling frustrations with you, and we'll all learn about best practices together!
Visug Geek Dinner
Presented by: All Visug members!
On: 21 December 2006
Would you like to meet fellow developers, and have some discussions over dinner you would normally have at the family table? Then come to our geek dinner, where we can discuss everything (yes, even your latest gadget!) while becoming a bigger person?
More info and registration at http://www.visug.be.


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Did you know that we're vibrational beings? In fact, everything has a vibration; our bodies, our furniture and even our thoughts. A vibration is "energy"; a moving, swirling vortex of power that brings us up into a better energy state or a down to a lower energy state. This depends on whether we are sending out positive "vibrations" or negative "vibrations". We emit a vibration every moment of every day.
Happy people send out a high vibration, and unhappy people send out negative vibrations. We love hanging out with high-vibration people because of the high vibration they're emitting and we want to avoid low-energy people because they're emitting a low vibration and you know it, either consciously or subconsciously.
Where are we getting this vibration? Our vibrational energy goes up or down based on the foods and beverages we consume, toxins in our body, people we surround ourselves with and our emotional as well as mental conditioning; you know, the rules we were raised with. Some things have a high vibration for one person; let's say high school memories. The same thoughts and feelings about high school memories may provide great vibrational energy for one person because of the great times experienced, yet they may be a low-vibration for someone else because of unique-to-them unhappy experiences.
So, if everyone and everything has a vibration, and it does, so does food. The higher the quality of foods, the higher the vibration of these foods. When we're feeling happy, confident and healthy, you'll more easily gravitate to higher quality foods. Some foods could be high-vibrational and healthy for one person, yet be low-vibrational, and unhealthy to another. For example, strawberries could enhance one person's health and it could interfere with another person's health and energy levels. This is where everyone is unique.
But when we're stressed, depressed, lonely, tired; we'll find ourselves more easily gravitating to low-energy or no-energy foods, possibly those comfort foods from our childhood that we thought connected us to the love of our family.
Or, there could be foods that quickly raise the brain chemicals that have been falling or have become imbalanced because of stress. High carbohydrate foods, salty foods, fatty foods, pop and chocolate are the common ones that come to mind.
And it's a vicious cycle. Someone starts off on a health program, yet before the day or the week is over, they give into certain comfort foods, despite their best intentions. They can't understand why, when they've made a commitment to health, they can't even make it through the 1st week, which is why many New Year's resolutions fail.
Also, when the blood sugar in the brain becomes depleted, it overrides your conscious mind with its good intentions and it demands instant energy. Our brain requires a variety of specific nutrient-dense foods to balance it again. But we'll generally choose low-vibrational quick-energy foods in a crisis situation because the wisdom of the brain says "I need fuel NOW". Unfortunately, it's that instant low-vibrational foods that raise it the quickest. So, what and when you eat is crucial to maintaining a high vibration in your mind and body.
How many eating disorders, depression, obesity and stress issues are connected to imbalanced hormones, deficient brain neurotransmitters, vitamin and mineral deficiencies, amino acid deficiencies or toxicities in the body which travel to the brain through our bloodstream?
We really are our own best research projects. We need to be present and attentive to our habits, our thoughts, our feelings and of course, our actions.
Those are the healthy foods you always keep on-hand, foods that you want to gravitate to in restaurants, at parties; anytime, anywhere. It's the foundation of a solid healthy eating program. An abundance of different coloured fruits and vegetables, whole grains, beans, lentils, lean proteins, nuts & seeds, healthy fats and healthy beverages help to create a healthy body. This makes sense, doesn't it? Also, when you keep your emotional vibration high, you'll more easily stay on track with high vibrational foods. Not to say that you can't have a little fun food once in a while, but typically those of us on the health path choose high quality foods most of the time.
Trigger foods are generally cookies, pastries, creamy carbs, ice cream and other dairy products, salty foods, chocolate, pop (especially with aspartame); all things that you'll find on the low-vibrational chart. The more stressed you get, the more you may find yourself gravitating to these foods.
Do you find yourself craving any of these foods? Well, the truth is, most people do. According to my friend who specializes in eating disorders, about 95% of the population stress or comfort eats, either a little or a lot.
I knew a lady, whose dad was a baker, and he brought home fresh warm bread as a treat when she was a child; in other words, that equated to food being love for her. As an adult, when life got stressful or overwhelming, bread, and especially warm white bread, brought back the love and she felt safe and comforted again. Do you have a food that brings back the comfort of love for you? The next question to ask is this: is it healthy or nutritionally lacking?
Here's another example: Have you ever hurt yourself as a child and then heard your mother say "Oh honey, don't cry. It'll be all right. Here, have a cookie." My job for many clients is to reprogram them to healthier self-loving habits that'll serve them so much better. The parents were unknowingly programming their children to stuff their feelings and these now-adults are still stuffing their feelings with cookies. That's called self-sabotage OR a softer name is called
stress and comfort eating.


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This Day in Georgia History
December 21, 1732
Oglethorpe Resigned and Sold Stock
While James Oglethorpe was at sea sailing to America with the first Georgia colonists, the sale of all of his stock in the Royal African Company (then worth about £1,000) was finalized. Also before embarking, Oglethorpe apparently resigned from the board of governors of the company.
To view a publication on James Oglethorpe, see the Digital Library of Georgia.


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Recent Feedback
About this submission
A semi-autobiographical television pilot examining the matrilineage (female lineage) of one family from Slovakia to America, addressing womanhood, desire, regret, disease, addiction and strength.
NOTE: This is the beginning of the pilot, where I introduce all five of the main characters, set the pace and tone of the show.
Amanda Blanchard
Glendale, CA, USA
I am a screenwriter and aspiring television writer currently working as a Writers' Room PA for Chucky - Season 1. I have a background in theatre, sketch comedy, feature screenwriting, and making independent short films. My goal is to become a staff writer on a television show. Writing alone can be amazing, but being in a room collaborating is even better!


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Akala Oluwa'tomi. He is an RnB/ pop artiste with Tomie Tim as his stage name. His passion for music has been since his childhood days. During his Secondary School days, he was a member of a gospel group known as the "Holyghost Rappers". The group performed at various Christian ceremonies and weddings.
Later on, he started performing at school shows where he gained popularity among his peers. He paid his dues in the music scene by serving as back-up artist to many indie artists and by participating in school shows and talent hunts.
He is currently signed to no record label. Apart from being a singer, he is also an actor, this is another talent he has developed with time. Follow him on twitter @PappyTunes.[audio:https://www.360nobs.com/wp-content/uploads/2012/06/Replay.mp3|titles=Replay]
Tomie Tim - Replay (2.5 MiB, 1,327 hits)


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There are two basic motivating forces: fear and love. When we are afraid, we pull back from life. When we are in love, we open to all that life has to offer with passion, excitement, and acceptance. We need to learn to love ourselves first, in all our glory and […]
Tag: ability
your ability
You are the only person on earth who can use your ability. by Zig Ziglar あなたはこの地球上で、あなた自身の能力を使うことができる唯一の人です。


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Chautauqua farewells fans at Turnbull Stakes Day at Flemington Racecourse on October 06, 2018 in Flemington, Australia. (Reg Ryan/Racing Photos)
Racing Victoria Staff@RacingInsider
9 October, 2018
The ups and downs of racehorse ownership have been embodied by Rupert Legh so far this Spring Racing Carnival, with the prominent owner experiencing a particularly bittersweet day on Turnbull Stakes Day at Flemington on Saturday.
The Melbourne-based businessman owns or part-owns several horses, which race in his distinctive purple and yellow silks with a lightning bolt; but none more high-profile than Chautauqua, who bade farewell to Flemington on Saturday after winning six Group 1s and more than $8.8m in prizemoney during a glorious career on the racetrack.
The 'Grey Flash' paraded in front of 22,000 appreciate racegoers, and Legh admitted there was a lump in his throat when he heard the reception given to the enigmatic sprinter.
If that was a bittersweet moment Legh felt only joy when, just before Chautauqua said 'adieu' to Flemington, another horse he owns, the highly progressive three-year-old Wild Planet, announced himself as a potential star of the future with an heroic win in the Listed Antler Luggage Stakes.
Those moments, in a nutshell, perfectly encapsulate the joys and occasional sadness of racehorse ownership, according to Legh.
"Saturday was an emotional day for many reasons," he said.
"We were obviously delighted with the win of Wild Planet, we've always had high hopes for him and although he's not the finished article yet, we think he's a very exciting prospect.
"Then 30 minutes later, I had mixed feelings during Chautauqua's parade. He's given us so much joy and it was great to hear the crowd's reaction, but we would've obviously loved to see him race one more time."
Legh's Spring Racing Carnival rollercoaster ride began on Makybe Diva Stakes Day, when he enjoyed one of his greatest days on a racetrack with twin successes for a pair of O'Reilly-sired horses, Brutal and Grunt.
Three-year-old colt Brutal maintained his unbeaten record with a tough front-running win in the Listed Antler Luggage Plate (1400m), before classy entire Grunt added the Group 1 Makybe Diva Stakes (1600m) to an already impressive CV that also includes victory in the Group 1 Australian Guineas (1600m) last season.
"I've had some special moments in racing, but I can't think of too many days like that," he reflected.
"To win any race during the Spring Carnival is quite a feat as the level of competition at this time of year is at its peak. To win two stakes races, including a Group 1, is just remarkable and I'm certainly very thankful and appreciative."
Unfortunately for Legh, Brutal was soon ruled out for the remainder of the Spring Racing Carnival after suffering a minor injury, while Grunt soon followed him into the paddock after his trainer Mick Price ruled out a rematch with the mighty mare Winx in the Ladbrokes Cox Plate.
"I guess that's racing," Legh said. "You have to enjoy the wins because you're going to lose far more races than you win. Just when you think you're ahead, racing has a habit of bringing you back down to earth. But that's why we love it."
13 May, 2020
12 May, 2020
22 April, 2020


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Daily Numeroscopes
About 512 B.C., Pythagoras devised a system of numerology that can help you create the life you desire for yourself.
At Life Path Numerology Center, we believe you are one of the people who want to be in control of your life. Therefore, we offer you a subscription to the most accurate and detailed preview of your day available through the internet.
By signing up below, you'll get a daily entry with 3 separate sections designed for you to take charge of your life, including general daily trends, business and finances, and relationships and social.
The Daily Numewrocopes are sent out at separate times to each of four time blocks so that everyone, no matter where in the world, receives the daily entry no later than 6:00 AM.
Each person is in one of nine personal year cycles based upon his/her date of birth.
Sign-up is a three step process:
To be sure you receive the correct entry at the appropriate time, follow the instructions for each step. This more detailed process is required by the variables for each subscription.
1) Choose your time block,
2) Choose your correct list,
3) Fill out the form,
Let's get started.
Time Block 1: All North America and Western South America
United States of America (all), Anquilla, Antiqua, Burbuda, Argentine, Aruba, Belize, Bermuda, Bolivia, Brazil, Canada (all), Cayman Islands, Chile, Columbia, Costa Rica, Cuba, Dominica, Dominican Republic, Easter Island, Ecuador, El Salvadore, Falkland Islands, French Guiana, Grenada, Guadaloupe, Guatamal, Guyana, Haiti, Honduras, Jamaica, Martinique, Mexico, Montserrat, Netherland Antilles, Nicaraqua, Panama, Peru, Puerto Rico, Saint Kitts Nevis, Saint Lucia, St Vincent, Suriname, Venezuela, Virgin Islands.
Time Block 2: Eastern South America, Western Europe, Western Africa
Albania, Algeria, American Samoa, Andorra, Angola, Austria, Azores, Bahrain, Belgium, Belorus, Benin, Bosnia Herzogovin, Botswana, Bulgaria, Burka Faso, Burundi, Cameroon, Canary Islands, Cape Verdi, Central African Republic Chad, Comoros, Congo, Cote D Ivoire, Croatia, Cyprus, Czech Republic, Denmark, Djibonti, Egypt, Equatorial Guinea, Eritrea, Estonia, Ethiopia, Faroe Islands, Finland, France, Gabon, Gambia, Germany, Ghana, Gibraltor, Greece, Greenland, Hungary, Iceland, Ireland, Israel, Italy, Jordan, Kenya, Kuwait, Latvia, Lebanon, Lesotho, Liberia, Libya, Liechstenstein, Luxembourg, Macedonia, Madagascar, Malawi, Mali, Malta, Mariotte, Mauritania, Moldova, Monaco, Morocco, Mozambique, Nambia, Nettherlands, Niger, Nigeria, Norway, Poland, Portugal, Qatar, Reunion, Rwanda, Saint Helena, San Marino, Saudi Arabia, Serbia Montenegro, Sierra Leone, Slovakia, Slovenia, Somali, South Africa, Spain, Sudan, Svalbard JanMayon, Swaziland, Sweden, Switzerland, Syria, Tanzania, Togo, Tunisia, Turkey, Ukraine, United Kingdom, Yemen, Zambia, Zimbabwe
You were born into 1 of 9 personal year cycles. Because of the time differential for subscribers in different parts of the world, the daily entries are sent out at 4 separate times. To be sure that you receive the proper entry at the right time, the subscription process unfortunately requires a few extra steps. We have simplified the process as much as possible.
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Time Block 4: Eastern Asia, Australia, New Zealand, Pacific Islands
Australia, Cook Islands, Fiji, French Polynesia, Guam, Mariana Islands, Marshall Islands, Midway Islands, Chatham Islands, Micronesia, Naura, New Caledonia, New Zealand, Niue, Norfolk Islands, Russia (eastern), Samoa, Solomon Islands, Tonga, Tuvalu, Wake Islands, Wallis Futuna.
Time Block 3: Eastern Europe, Eastern Africa, Asia
Afghanistan, Armmenia, Azerbaijan, Bangladesh, Bhutan, Brunei Daressalem, Cambodia, China, Christmas Islands, Cocos Islands, Georgia, Hong Kong, India, Indonesia, Iran, Iraq, Japan, Kazakistan, Korea, Krygyzstan, Lao People's Republic, Macao, Malaysia, Maldives, Mauritius, Mongola, Myanmar, Nepal, Oman, Pakistan, Palau, Phillippines, Romania. Russia (western), Seychelles, Singapore, Sri Lanka, Taiwan, Tajikistan, Thailand, Timor Leste, Turkmenistan, United Arab Emirates, Uzbekistan, Viet Nam.


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Are you tired of spending $5 or more on a protein box from Starbucks? Or a snack box your local grocer? Do you wish you could have, a customize box with EVERYTHING suited to your taste? Well, if you do, you are in luck. You can have an affordable, fresh, and customized snack. Another bonus of… Continue reading How to Make Your Own Snack Box
Tag: Weight loss
Be a Planner, Save Money $$
The saying " failure to plan is planning to fail" rings true in healthy eating. What if you could save money and lose inches at the same time. Well, you can do both, if you plan. Planning what you eat can prevent overeating and spending too much. You will find helpful tips that have… Continue reading Be a Planner, Save Money $$
Makeover Monday- Cajun Inspired Rice
Do you love Cajun rice? Do you want some of the Cajun flavors without all the calories and carbs, while saving money. Then try this recipe using leftover food to create this Cajun inspired rice recipe. We all have days were we are unable to meal prep fully and need a flavorful meal on the… Continue reading Makeover Monday- Cajun Inspired Rice
5 Tips To Eat Better
Do you wish you had a personal chef or could afford to have someone prepare of all of your meals? Life would be a lot simpler if you didn't have measure, prepare, and plan your meals. A girls gotta live, work, maybe even take the kids to games, or in general just keep up with… Continue reading 5 Tips To Eat Better
Oatmeal for Breakfast
Don't let oatmeal fool you into thinking it is boring and your mothers breakfast food. It really is awesome pantry staple. It contains soluble fibers that help lower cholesterol and insoluble fiber that provides that prevents your bowels from being clogged up. Not only does it have health benefits its relatively inexpensive and can be… Continue reading Oatmeal for Breakfast
Monday Makeover-Pizza Shorcut
It's makeover Monday and I have been craving pizza. My favorite pizza is Marcos Pizza, but I can't afford to fit it in nutritionally because it's pumpkin spice season. I prefer to allocate my macros towards treat meals with pumpkin spice or candy corn. Pizza doesn't have to be the enemy with a few simple… Continue reading Monday Makeover-Pizza Shorcut
Makeover Monday- Quaker Morning Go- Kit
Welcome to makeover Monday, were I find something I like and recreate it healthier or more budget friendly. If you are like most of us, you are constantly in a hurry in the morning and need something with protein, carbs, and the right amount of calories to fuel your day? Well, I found this Quaker… Continue reading Makeover Monday- Quaker Morning Go- Kit


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"Let Us Negotiate"
Don C. Bentley
A hunter raised his rifle and took careful aim at a large bear. When about to pull the trigger, the bear spoke in a soft soothing voice, "Isn't it better to talk than to shoot? What do you want? Let us negotiate the matter.
Lowering the rifle, the hunter replied, "I want a fur coat.
"Good said the bear, "That is a negotiable question. I only want a full stomach, so let us negotiate a compromise."
They sat down to negotiate, and after a time, the bear walked away alone. The negotiations had been successful. The bear had a full stomach, and the hunter had his fur coat.
Satan says, "let us negotiate." But there are some things that cannot be compromised. If we try to compromise with sin, we are deceiving ourselves and will fall into a trap that will destroy us."
"Abstain from every form of evil." (I Thes. 5:22)


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Pregnancy brings about one of the most beautiful parts of life, but it can also take a hard toll on the body of a woman. Some women are blessed with glowing skin during their pregnancy, but others experience some less than desirable changes in their appearance.
Dramatic changes in hormones, particularly estrogen and progesterone, are to blame for both the good and the bad skin and hair changes that can happen during pregnancy. To help you counteract the not-so-glowing changes, our Greeley dermatology services will help you to safely treat the skin, hair and nail changes that you may be facing as you wait for your sweet new baby.
Hair Growth
One of the most common changes during pregnancy is hair growth. Thanks to prenatal vitamins and hormones that slow down hair loss, many women find themselves with a head full of extra, fuller, thicker hair that is also shiny, strong, and healthy. The downside to extra hair growth is that you may find hair growing in places you don't want it to. Women have often complained of hair growing on their face, neck, abdomen, and other areas of the body. Thankfully, shaving and waxing are both safe during pregnancy to help you keep unwanted body hair at bay. Hair growth will also slow down after giving birth or may even shed, which is good for the unwanted hair, but unfortunately it may also affect your new more voluminous hair do.
Hormonal changes can often be blamed for breakouts, particularly during menstrual cycles and likewise during pregnancy. The increase in hormones can cause oilier skin and lead to acne. Acne during pregnancy can be one of the most frustrating changes as it can affect more than appearance, but also self-esteem and self-image. Pregnancy can also limit treatment options, making it even more difficult. However, with the help of a board-certified dermatologist you can find ways to safely treat acne when you're pregnant. Click here for some potential ingredients that help counteract pregnancy acne or read this article for 6 all-natural pregnancy acne remedies.
Glowing Skin and Rosy Cheeks
For those lucky women who don't find themselves fighting acne like they did as a teenager, their complexion is brightened with beautiful glowing skin. During pregnancy, the body can produce up to 50 percent more blood, increasing circulation. Increased blood flow will also increase oil production, which causes that pregnancy glow and cheery rosy cheeks. To help keep that glow from turning into a breakout, buy a gentle oil-free cleanser formulated for oily skin.
Stretch Marks
Stretch marks are another of the most common pregnancy side effects. While nearly 90 percent of pregnant women will get stretch marks, the amount and size of stretch marks will vary by woman. Stretch marks can appear on various areas of the body and can range in color from red, brown or purple. While some women believe exercising and cocoa butter can make all the difference, these types of remedies have not been medically proven to help.
A qualified dermatologist can talk with you about ways they can help reduce the appearance of stretch marks.
Itchy Skin
As baby and belly grow, skin stretches and tightens causing itchiness. Although its normal for itchiness to be uncomfortable, if it becomes severe or accompanied with other symptoms such as nausea, vomiting, or red raised patches on the skin, make sure to consult with your doctor.
Dark Spots
Pregnancy also causes melanin to increase in the skin and lead to dark spots on the face called chloasma. These often blotchy patches typically appear on the forehead, cheeks and upper lip and can affect up to 75 percent of women. While there isn't much that can be done to treat them, wearing sunscreen and limiting your time spent in the sun can help minimize the risk.
Spider And Varicose Veins
Increased blood volume, blood flow, and pressure on your veins from a growing belly can also cause your blood vessels to grow, leading to the appearance of spider veins or varicose veins. Spider veins, the tiny red veins that branch outward, can appear on the face, neck, chest,
Dark Line Down Your Belly
Around 75 percent of women develop a dark line that runs from their belly button down to their pubic bone. Like other skin changes during pregnancy, the dark line will likely fade away after birth.
Contact a Trusted Dermatologist
If you're concerned about some of the skin and hair changes during your pregnancy, don't hesitate to reach out to Front Range Dermatology to see how we can help.


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gene, as detected by an FDA-approved test, or companion
diagnostic (see sidebar on Companion Diagnostics). At the
same time, the FDA approved a companion diagnostic, the
LeukoStrat CDx FLT3 Mutation Assay, to identify patients
with AML with the FLT3 mutation.
Midostaurin was approved for use in both the induction
and consolidation phases of treatment for AML after it was
shown in a phase III clinical trial that patients with FLT3-
mutated AML who received midostaurin and standard
induction and consolidation cytotoxic chemotherapy had
a more than 20 percent improvement in overall survival
compared with those patients who received placebo with
standard treatment (134).
In April 2017, the FDA also approved midostaurin for
treating adults with certain aggressive forms of a rare
disorder known as systemic mastocytosis. In patients with
this disorder, immune cells called mast cells accumulate
in internal organs such as the liver, spleen, bone marrow,
and small intestines.
Research has shown that most cases of systemic
mastocytosis are caused by mutations in the gene that
encodes the KIT tyrosine kinase receptor, which is one
of the targets of midostaurin (135). The approval of
midostaurin for treating aggressive systemic mastocytosis,
systemic mastocytosis with associated hematological
neoplasm, and mast cell leukemia was based on clinical
trial results showing that a proportion of patients with
these disorders benefited from the molecularly targeted
therapeutic (136).
Soft tissue sarcomas are a diverse group of more than 70
types of cancers that arise in soft tissues of the body, such
as the muscles, tendons, fat, blood vessels, lymph vessels,
nerves, and tissues around joints. These cancers are rare;
12,390 U.S. adults are expected to be diagnosed with a soft
tissue sarcoma in 2017 ( 2).
Patients with metastatic soft tissue sarcoma have a
poor prognosis. Many are treated with the cytotoxic
chemotherapeutic doxorubicin, either alone or in
combination with other cytotoxic chemotherapeutics,
but even then overall survival is estimated to be just 12 to
16 months (137).
In October 2016, the FDA made a decision that provides
a new treatment option for patients with advanced
soft tissue sarcoma. Specifically, the agency granted
accelerated approval to the molecularly targeted therapeutic
olaratumab (Lartruvo) for treating patients with soft tissue
sarcoma who cannot be cured with radiation or surgery
allow patients to receivea treatment to whichthey are most likely torespond; andallow patients identifiedas very unlikely to respondto forgo treatment with thetherapeutic and thus bespared any adverseside effects.
Adapted from ( 1)


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In response to Allardes' proposal, recommends that for the duration of the recoinage the Scots be allowed to revert to their old practice [adding copper during melting] as this seems to be the only practicable method of producing standard coin there.
- Additional Information
- Notes on the Electronic Edition
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- Revision History
- 1 January 2001
- Catalogue information compiled by Rob Iliffe, Peter Spargo & John Young
- 29 September 2011
- Catalogue exported to teiHeader by Michael Hawkins
- 23 July 2015
- Will Scott began transcription from NC 4: 500-1
- 5 August 2015
- Will Scott finished transcription from NC
- 22 August 2016
- Will Scott tagged transcription
- 18 September 2016
- Will Scott finished tagging
- 8 June 2017
- Minor amendments made by Will Scott
- 1 January 2001
- Download MINT00388.xml and schema (advanced users only)
- Notes on the Electronic Edition
To the Right Honourable the Earl of Godolphin Lord High Treasurer of great Britain.
May it please your Lordship
In obedience to your Lordships Order of Reference of the 12t Instant upon the Memorial hereunto annexed, we have considered the said Memorial & since by experiments made in that Mint the silver in melting with Scotch coal & lading out refines about three half penny weight in the pound weight Troy as is alledged in the said memorial & the moneys coyned by the ancient method of that mint have passed the trialls of the Pix & in the last trial proved standard full & there is no time at present for making experiments to bring this matter to an exacter regulation. We are humbly of opinion that the Officers of the said Mint may be still allowed to use their ancient method of allaying the molten silver to make it standard untill the present recoinage of the moneys in Scotland shall be finished. the Indenture of the mint prescribing no particular method for melting provided it be standard
All which is humbly submitted to
your Lordships great wisdom.


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Brazil's federal police have asked the supreme court to indict President Michel Temer and confiscate his assets and those of some of his close associates over alleged graft, according to a copy of its report for the court, seen by Reuters on Tuesday.
Police have been investigating Temer for allegedly taking bribes in return for helping shape a decree regulating Brazil's ports, and in particular for extending concessions in the port of Santos to benefit companies of close associates.
Temer, a former vice president who took office in 2016 after former President Dilma Rousseff was impeached, has repeatedly said he is innocent.
He has faced several graft allegations, but is immune from prosecution while in office, unless the supreme court decides to strip his immunity.
Supreme Court Justice Lugs Roberto Barroso, who is overseeing the case, said on Tuesday he would wait to see the findings of Brazil's public prosecutors' office before deciding on how to proceed.
The report produced by the federal police recommends that Temer, his daughter Maristela, his former advisor Rodrigo Rocha Loures and eight others face charges and have their assets confiscated for their role in allegedly laundering bribes through real estate transactions.
Temer's office did not immediately respond to a request for comment.
His term ends on January 1, and with it his immunity from prosecution.
The federal congress voted twice last year to block Temer from standing trial in the Supreme Court on three corruption charges leveled against him.


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spaceworkers® is an architecture and design studio located in Paredes in northern Portugal, directed by architects Henrique Marques and Rui Dinis.The studio based its practice on the exploration and constant search of new paradigms of contemporary architecture in order to achieve a close relation between the form and emotions.His works reflect the pragmatic vision with they face the challenges, and the critical spirit that evaluate the context that surrounds them. The works represented in the video demonstrate how the studio adapts its interventions in different contexts of space and place without ever losing the values that guide themselves.
- Dirección
Rua Central do Bairro nº792
4580-591 Paredes
+351-255781150 www.spaceworkers.pt


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Leprosy Mailing List – August 31, 2013
Ref.: (LML) ILEP survey research priorities of leprosy field workers
From: June Nash, London, UK
Dear Dr Schreuder,
The ILEP Technical Commission (ITC) is looking at research priorities. We would like to have input from people who are working in the leprosy field and in particular basic health workers. It would be helpful if people on the mailing list could give us their top three research priorities for leprosy in the future. If they had opportunities to ask that question to the basic health workers on their team and could also give their answers that would be very helpful.
People can contact me on this email email@example.com
Many thanks.
Yours sincerely,
June Nash
member of ILEP ITC
LML - S Deepak, B Naafs, S Noto and P Schreuder
LML blog link: http://leprosymailinglist.blogspot.it/
Contact: Dr Pieter Schreuder << firstname.lastname@example.com


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FORS is pleased to announce the launch of FORS Fleet Tools – a free online information system to help members accurately collate and manage fleet related data.
FORS Fleet Tools will provide FORS operators with a hassle-free, consistent platform to demonstrate how their fleets are meeting the specific environmental, safety and efficiency requirements set out in the FORS Standard.
Created in collaboration with FORS Affinity Partner FleetCheck, FORS Fleet Tools is free to access for FORS members and contains a range of toolkits to help operators collate the specific fleet management data needed to fulfil the requirements at each level of the FORS progressive accreditation.
FORS Fleet Tools will also help FORS members identify areas for improvement across their fleet and monitor their progress through the FORS Bronze, Silver and Gold accreditation levels as they strive towards even greater efficiency, environmental and cost-saving goals.
Toolkits contained within FORS Fleet Tools include:
- A fuel tracker to record and monitor fuel usage, miles per gallon, CO2 levels and efficiency improvements. Monitoring fuel use is required at all levels of FORS accreditation, and members are able to access the toolkit relevant to FORS Bronze, Silver or Gold requirements*
- A penalty charge notice tracker to monitor and manage potential incidents and help members reduce the number of penalties received**
- An incident tracker to record, track and monitor incidents involving drivers or vehicles, including service and roadworthiness and road traffic collisions***
FORS Fleet Tools offers the ability to upload, store and submit FORS Silver and Gold evidence. Paul Wilkes, FORS Business Services Manager said, "Improving safety, boosting efficiency and safeguarding the environment are the guiding principles of FORS. In order for our members to raise standards and improve efficiencies, they must measure and monitor their whole fleet.
"FORS Fleet Tools makes this task simple, allowing members to upload their data for all vehicles in their fleet, enabling them to monitor and analyse whole fleet performance helping them to become more efficient as they progress through the levels of FORS accreditation."


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Procrastination Emotionally Focused Couples Therapy (EFT)
Procrastination is not the same as laziness, instead, it is a severe condition that millions of people experience on an ongoing basis.
Most procrastinators wish that they were more productive in order to achieve their goals and dreams. Unfortunately the force of procrastination destroys their ambitions and aspirations, and telling them to "get a grip" doesn't help at all. Procrastination is similar to obsessive compulsive disorder in that the person doesn't choose the behavior and can't change it by simply making the decision to be more productive.
A person with procrastination issues tends to disappoint other people by not meeting their deadlines or promises. They find it hard to start on new projects, or switching from one to the next. They chronically underestimate or overestimate the duration of tasks and struggle to get going. Even when they want to start on a task, they may have difficulty establishing a starting point. Disorganization and clutter fill their work spaces and homes. Procrastination is a passive resistance that expresses the resentment of the fact that procrastinators are often unable to say no. They will do anything, except what they should be doing and tend to focus on short term happiness over long term success.
Psychotherapy can help a person to overcome procrastination issues. A therapist will assess the causes of your procrastination and find ways to solve these issues. Sometimes, strategies for self-acceptance and increasing energy levels are all that's needed.
If you are looking for a counsellor or psychologist who offers counselling approaches to address your procrastination issues, you may want to search the directory to find a professional whose approach will suit you best.
Emotionally Focused Couples Therapy (EFT)
Emotionally focused therapy (EFT) has helped couples and family members to treat distressed relationships, depression and a range of other emotional difficulties. It is one of the most common treatments used in private counselling and psychologist practices, training centres and hospital clinics around the world.
The main goal of Emotionally focused therapy is to create a secure bond between romantic partners and to reorganize and expand critical emotional responses. It helps to improve communication between partners, which is more beneficial to the relationship. EFT is a practical therapy that has been used successfully in relationships and marriages for many years, due to the fact that it creates a spirit of respect and harmony.
Emotionally Focused Couples Therapy generally only lasts between six to twenty sessions and has been shown effective in 90% of relationships.
If you are looking for a therapist who offers Emotionally Focused Couples Therapy, please browse our list of practitioners below..
Note: Some practitioners practice Emotion Focused Therapy rather than Emotionally Focused therapy. You will want to confirm that it is indeed Emotionally Focused Therapy that the counsellor/psychologist practices.
Note: You may narrow your search by selecting more than one filter below.
- (-) Remove Procrastination filterProcrastination
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- This event has passed.
Rosebank Plus and MYHR present "Kick Start the year and get the best out of your work force".
February 28, 2019 @ 7:45 am - 10:00 am
Following on from our successful HR workshops in 2018, we bring to you our next workshop that will focus on helping to take your business to the next level with your biggest asset- Your People!
Join us, where you'll learn how to deliver and use feedback effectively, tips in coaching and how to have those tough conversations (in the right way of course) that will help maximize your people's potential! And subsequently improve productivity.
Our HR Partner and highly sought-after HR specialist, Jason Ennor from MyHR, will cover:
- The best process for coaching to get results
- The importance of how to deliver and receive feedback and the power of getting this right
- The importance of having hard conversations (and the fall-out of avoiding them)
- How to best manage tough conversations with your people
Outcomes of the workshop:
- Learn how to better support your people to be able to reach their potential
- Learn how to handle and prevent performance and behavioral issues in your team
- Ability to create a work environment where communication is constructive and free-flowing
This is a practical and interactive session with like minded leaders, managers and business owners, where you'll have the opportunity to take your knowledge straight back to the workplace.


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:: Is it just me loving everything this man produces or does he keep getting better and better with every … More
Tag: Teen Daze
New: Teen Daze – Reykjavik, January 2015 (Alternate Version) [Free Download]
:: Original and alternate version both are excellent tracks. Really looking forward to the EP. https://soundcloud.com/teendaze/reykjavik-january-2015-alternate-version Canadian ambient and … More
Nils Frahm – You (Teen Daze Rework) [Free Download]
:: Pure beauty. Enjoy! Vancouver's electronic producer Jamison, better known as Teen Daze, has done a rework of You, … More
New Album: Teen Daze – Glacier (2013/10/01) [Full Album Stream]
:: Think I just found my winter album. Sounds like a warm embrace feels like… It's not even a year … More
New Album: Teen Daze – The Inner Mansions (2012/11/06)
:: Captivating. Spirited. Stunning. 'The Inner Mansions' is the sophomore album of Canadian artist Teen Daze, and his second release … More
New Single: Teen Daze – Discipleship [Free Download]
:: Put on some decent headphones, sit back and listen to this marvellous track! Discipleship is the new single … More
Teen Daze – Erbstuck / New Album 'All Of Us, Together'
:: This is electronic love. Pure and full of joy! Jamison aka Teen Daze is an artist from the Fraser … More


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Call of Duty: Roads to Victory NA PS Vita CD Key
Call of Duty®: Roads to Victory delivers the intensity of being closer than ever to the fury of combat during the battle for the Liberation of Paris, the most harrowing campaign of WWII, known as The Normandy Breakout. Through a seamless narrative, Call of Duty 3 delivers the rush of unrelenting battle and breathtaking action of the Allied offensive that changed the fate of the world.
If you have a PlayStation Code, follow these step-by-step instructions to use it at PlayStation Store on your Playstation:
- Go to Redeem Codes.
- Follow the on-screen instructions to enter the voucher code details. (Once complete, select Continue.)
- Select Confirm.
- Select Download. (Once complete, the item will be added to your Download List.)
- Access your content. (Go to the relevant category on the XMB™ Menu to start playing your content.)
If you have any problems regarding activation, please contact us:


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Problem with : computed field
Hi, I'm trying to display a view with a computed field ;
The php code is : $date = $node->field_planning_maj0['value'];
$djour = date('Ymd');
$date1 = strtotime($date);
$newdate = date("Ymd", $date1);
$new = strftime("%A %d-%m-%Y à %H:%M", $date1);
if($newdate <= $djour )
$node_field0['value'] = $new;
$node_field0['value'] ="";
the problem is when I created or updated a node, the field appears but when I click in the navigation menu, it doesn't appear : The display shows an empty field in the view.
I have no idea, somebody can help me.
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- Question type: General