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Salesforce Online Training Solution
24×7 accessible online learning management system (LMS) that has been designed to be used and understood easily.
The Salesforce online training has been designed to enable users to clear Salesforce Certification.
The training is led by industry experts and comprehensive learning material will provide an insight to master Salesforce.
Salesforce Online Training
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200 hrs e-learning content
Training by industry expert
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Aligned with the industry needs, our curriculum has been timely updated to impart quality training.
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Salesforce Admin
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Certification Assistance
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AlmaMate is a leader in Salesforce training. It has trained and placed over 1000 professionals in Salesforce. Training in AlmaMate offers the following unique advantages:
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Professional Training Certificate


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Notice of special meeting
PIQUA — Notice is hereby given that Piqua City Commission City Manager Assistant City Manager and Finance Director will meet to review the 2016 budget for the City of Piqua. The meeting will be held on Thursday, November 191 2015 and will begin at 4 p.m.
The meeting will be held in the Administrative Conference Room on the 2nd floor of the Municipal Government Complex located at 201 W. Water Street.
Contact Information: Debbie Stein, executive assistant to city manager (937) 778-2051.
New all-way stops at Park and Westview, Park and Parkway
PIQUA — A traffic pattern change has been made at the intersections of Park and Westview as well as Park and Parkway. These intersections are now all-way stops. Please close attention and make sure you stop at these stop signs. The police department will be monitoring these intersections for enforcement.
Mainstreet Piqua to host annual meeting
PIQUA — Mainstreet Piqua will be hosting its annual meeting on Tuesday, Nov. 17 and interested Piqua residents, businesses and civic leaders are invited to attend. The meeting will be held on the fourth floor of the Fort Piqua Plaza with refreshments and networking at 8 a.m. and the formal program will get underway at 8:30 a.m.
During the annual meeting the downtown organization will take time to recognize individuals and businesses who they believe have significantly helped the downtown and the Piqua community. Following the awards presentation, and a celebration of the Mainstreet Piqua accomplishments in the last year, the attendees will be treated to a presentation by Joyce Barrett. Joyce Barrett currently serves Executive Director for Heritage Ohio Inc. Ohio's statewide preservation organization whose mission is helping people save the places that matter, build community and live better. Heritage Ohio coordinates the Ohio Main Street program and is the lead advocacy organization for the Ohio Historic Preservation Tax Credit. Joyce's presentation will focus on why "Design Matters" and the importance of preserving the downtown core.
Mainstreet Piqua is a non-profit organization dedicated to the revitalization of downtown Piqua. The organization is responsible for a number of projects in the Piqua community including downtown beautification and hosts several events throughout the year including Taste of the Arts, Christmas on the Green and the Piqua Community Farmers Market. Anyone wishing to attend the meeting is asked to rsvp to the Mainstreet Piqua office at (937) 773-9355. More information about the organization can be found at www.mainstreetpiqua.com.

subset: commoncrawl


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Sierra Mannie who asked white gay men to stop appropriating the culture of black women. While some understood and agreed with the overall message of the piece, many others (including some of my friends) took offense to it. As you might guess, the blogosphere produced a number of passionate responses of agreement and disagreement.
For me, I cannot think of a more perfect introduction to intersectionality, a term developed by law professor Dr. Kimberlé Crenshaw. I've always found the term to be awkward and overly "academic," but the concept behind it is a good one. If you are unfamiliar with the term, I would suggest starting with the Wikipedia page and then read a couple of excellent articles here and here.
In Christian terms, it's a practical tool to help us follow the Golden Rule.
Christena Cleveland, a social psychologist, author, and speaker, puts it this way:
"But when we only pay attention to and promote stories that we personally find relatable and affirming, we blind ourselves to the ways in which we are cutting ourselves off from, silencing and marginalizing others. It's easy to think that only überprivileged people need to think intentionally about connecting with and creating space for marginalized voices. But those of us who straddle the line between privilege and oppression need to be equally vigilant in this area. We can be blinded by our single-minded vision to raise our own voice and in doing so, ignore and oppress those who have even less of a voice than we do."
I believe that is the concept (and opportunity) that many white gay men missed: while being oppressed in their own right, they are at high-risk for being blinded to others unlike them who are also oppressed. Instead of listening to this woman's story and experience, many simply responded in defensiveness. An opportunity for learning, connection, and a step toward reconciliation was missed.
While I have experienced some significant marginalization in society and in the church (I am a gay man), I also have an enormous amount of privilege (white, cis-gender male, U.S. citizen). Additionally, the acceptance of gays, lesbians, and same-sex relationships has increased and gained momentum in the U.S. in the past decade.
As someone with this mixture of privilege (a lot) and marginalization (some), I feel called and equipped to be a bridge between the two. Let me provide an general example. Often, those who are only just coming to terms with their own privilege have a lot of questions and experience a mild-to-moderate amount of shame, distress, and panic. Those who are marginalized often feel bombarded by the same questions and concerns by these folks. While the person of privilege may have honest questions, the onus really isn't on the marginalized person to provide soothing words of comfort! However, some of us, including myself, have the experience to be a bridge between those so marginalized that they do not have a significant voice in our society, and those who are struggling to understand their own privilege and the existence of significant systems of oppression. To put it more simply, I do have the time and the energy to answer these questions, to provide education, and to amplify the voices of the marginalized to the ears of those more privileged than I am.
I think a lot of the angst and tension between activists and bridge-builders can be explained by this misunderstanding of roles. Activists are marginalized people and their allies standing in solidarity, moving the conversation forward in the public sphere, and challenging the status-quo. Bridge-builders are marginalized people and their allies providing the way forward for those who are willing, yet still searching, questioning, and integrating their own experiences and shadows. Because we are equipped for different roles, we experience disagreement in methods, tone, strategy, and even purpose.
In the end, we are all reliant on the Holy Spirit to guide us in love. May we listen to the Spirit's voice and follow with courage. May we trust the Spirit to work in others as well, even if it looks strange and unsettling to us. May we always be open to critique, and may the Spirit give us discernment. And may we not miss another opportunity to celebrate our intentional diversity in the Body of Christ.


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Top Rated Local® is pleased to announce that Appear Photography is a 2019 award winner!
"I'm always blown away by Lori's work. She's creative, caring and so gentle with the little babies! She's just so easy to work with as well, which is why we continue to work with her. She's professional and has a beautiful studio with all the props, swaddles, and clothes you could want! We also have loved the outdoor photos we've taken with her. She's truly one of a kind to work with and our family highly recommends her!" -Martin S.
As one of the top 10 photography businesses in the entire state of Alabama, Appear Photography has tons of positive reviews, just like these — as well as a 95.08 Rating Score™ and a 4.81 average star rating on verified sites.
Not Your Average Company
We spoke with Lori Cummings, the owner of Appear Photography, about her business' impressive online reputation. This is what she says makes Appear Photography different from other photographers in the area:
"We have over 15 years of experience in the photography industry and this is our full-time profession. Our number one goal is for our clients to love their photos. We like to communicate with each client before their photo session to find out their preferences and the vision that they may have for their photo session. We are a husband and wife team with two sides to our business. We are both continually honing our skills to become better and better at what we do and each have our own niche in photography. Lynn's side of the business focuses on weddings, events and corporate photography, while mine focuses on newborn, children, and family photography. We're a full-service studio which means we not only shoot and edit photos, but we also offer professional finished products such as canvases and prints, high-end albums and other specialty printed items."
Building Success By Putting The Client First
Lori and Lynn believe wholeheartedly that their job is all about making the client happy. That has helped them earn their phenomenal reputation, both online and off.
So, what's Lori's advice to other business owners who want to build up a phenomenal online reputation? "When clients are happy, they want to share their experience with others. It's also ok to ask clients to give you a quick review online. Running contests or promotions every now and then is a good way to gain attention on social media. Most of all, if you focus on doing your absolute best at everything you do, people will notice your quality of work and attention to detail."
Thank you for speaking with us, Lori! Congratulations to the team at Appear Photography for being a 2019 Top Rated Local award winner!


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Pin It
Southern California Art Galleries
Southern California Art Galleries
Abstracts 2014
Open Art Calls Accepted Artists
Artist Cynthia Brannvall
Berkeley, California USA
Artist Statement
"White linen is the paper of [women], which must be on hand in great well-ordered layers, and therein they write their entire philosophy of life, their woes and their joys."
-Gottfried Keller, Der grüne Heinrich, 1854
-Gottfried Keller, Der grüne Heinrich, 1854
Wave is one piece of art from a larger body of work in which I collage vintage fabric fragments onto stretched crinoline in order to create abstract expressions that contain a variety of connotations. These material forms evoke nostalgia, memory, and a sense of history and culture that has been described through the handwork of women. They are the fancy edges of special occasion garments and under things—the bits and pieces of christenings, birthdays, graduations, weddings and funerals. Wave is the simplest gesture in the transference of this kind of cultural energy. It signifies the kind of movements that travel through the wind, across oceans, from one hand to the next as well as those feelings that swell and surge when we remember and anticipate what is to become.
The views expressed by our artists in their artist statements do not necessarily represent the views of our art galleries. Artists can be visually expressive but may verbally misrepresent their true intentions or idea
Southern California Art Galleries
If you are passionate about art collecting and would like to buy this beautiful artwork, give our Southern California art galleries a call. Our art gallery is a perfect place for art collectors.
Our owner and curator is Linnea Lenkus, who has two Los Angeles portrait studios and has a passion for high quality art. Her goal is to promote artists in her Southern California art galleries.


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Kelee Ringo (center) was just one of several sprinters who took Arizona by storm this spring. Who do you think deserves the title of Boys Sprinter of the Year.
Arizona MileSplit Boys Sprinter of the Year
Another track season has come and gone and to cap it off, we will present the nominees for athletes of the year in each boys and girls categories beginning with the sprints. The Boys 1600m wasn't the only premier event this season. This year, Arizona had 23 guys run wind-legal sub-10.90 performances for the 100m, a big spike from last year's total of 10. Have a look at our slideshow of nominees for the Boys Sprinter of the Year along with their season highlights. Voting ends on May 26th at 7pm.


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Miss. Community Colleges Ask For More Funding
100 People Rally At Capitol
Mississippi community colleges are asking for more money from the state.
About 100 people gathered at a Capitol news conference Tuesday to tell legislators they need more funding to achieve their objectives.
Eric Clark, executive director of the state community college system, said funding for the two-year schools plummeted after the start of the recession, while enrollment skyrocketed.
Clark said the result has been bigger classes and more part-time faculty members, plus delays in repairs and renovations on buildings.
Many of those at the news conference wore green T-shirts that imitated the "Survivor" TV show logo, asking for a 39 percent increase in funding.
Lawmakers say money is tight.
Clark said he doesn't expect to get a 39 percent increase, but hopes to get closer to pre-recession budget levels.


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This year's WBFSH general assembly and annual meetings take place in São Paulo, Brazil and is hosted by Associacão Brasileira de Criadores do Cavalo de Hipismo
The participants of the WBFSH general assembly and annual meetings 2014 have arrived to São Paulo during the course of the weekend. Saturday the WBFSH joint meeting of the Board and Executive Committee has taken place, and Saturday as well as Sunday the participants have had the opportunity to visit the Brasileiro de Hipismo Festival to watch the show jumping competitions, young horse ranking finals and auction.
The programme for the meetings Monday and Tuesday comprises many interesting presentations which we will summarize on this website during the next couple of days.


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the clinical development process is a major shift for
pharma. "What is changing is that we are now, more
than ever, better able to understand the reality of
patients' experiences," Tellier says. "And I think we'll
get there increasingly in the future; we will be able
to better understand the reality of the value that we
create for them versus building hypotheses on clinical trials, which are, in a sense, very specific experimental conditions, somewhat far from reality."
Consistency is the key, he believes, and to help
fully-transparent criteria by which decisions are
made. "Sometimes it's a difficult decision because
you have to cut resources for one product; you have
to reallocate, you have to cease some activities—
including some clinical trials," he says. "So I think
that the most important thing is not the decision
by itself, it's the criteria by which you arrive at this
decision. And if the criteria are fair, fact-based,
transparent—I think that the majority of the
decisions are relatively less difficult to take."
He refutes again the idea that it is not possible to
do think that if you are able to improve the element
of differentiation of the solution then you can be
both successful from a business standpoint and
very successful from a patient standpoint. If, in
the end, the model is focusing more on the reality
of the value delivered to the patient then there is
tremendous success for the company that will truly
deliver differentiated solutions."
To this end, he thinks pharma must better
understand sub-populations of patients, ensure they
can benefit from its products, and help them get
that benefit through access, better compliance and
Paul was General
Manager of
eyeforpharma from
2003 before movinginto his currentChairman role in 2009. Paul has a specialinterest in new projects, innovation, mediaand overseeing the general developmentand direction of the company.eyeforpharma is a global provider ofpharmaceutical business insights andnetworking. Our mission is to makepharma more open and valued, somethingwe promise to provide at our upcomingeyeforpharma Philadelphia 2016 summiton May 2-3. We're creating a movementfor industry leaders to redefine pharmato prioritize patient value. Be a part of thechange!
As we saw at the start, Tellier does not forget where
he came from and why he is in pharma. "I do think
physicians and pharma are on the same team and
we work together for the benefit of the patients, and
that's really what drives me," he concludes. "There
is so much medical need that still needs to be met,
and being able to join efforts across the different
stakeholders involved—providers, scientists, all
together—that level of collaboration really has to be


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Omni-Lite Industries Announces Voting Results from Annual and Special Meeting of Shareholders
CALGARY, ALBERTA, October 23, 2013 – Omni-Lite Industries Canada Inc. announces voting results from its Annual and Special Meeting of Shareholders held October 18, 2013 in Calgary, AB.
A total of 5,298,780 common shares representing 43.39% of the Company's issued and outstanding common shares were voted in connection with the meeting. Shareholders voted in favour of all items of business, including election of each director nominee by a substantial majority as follows:
David F. Grant 96.9%
Donald Kelly 97.0%
Norman Goodrich 97.0%
Shareholders voted 99.9% in favour to appoint MNP LLP as auditors, and 99.6% to re-approve the Company's 10% rolling stock option plan.
Omni-Lite is a rapidly growing high technology company that develops and manufactures precision components utilized by several Fortune 500 Companies including Boeing, Airbus, Alcoa, Ford, Caterpillar, Borg Warner, Chrysler, the U.S. Military, Nike, and adidas.
Except for historical information contained herein this document contains forward-looking statements. These statements contain known and unknown risks and uncertainties that may cause the company's actualresults or outcomes to be materially different from those anticipated and discussed herein.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
For further information: David Grant, CEO, Tel. No. (562) 404-8510 x107, or (800) 577-6664 (Canada and USA), Fax. No. (562) 926-6913, email: email@example.com
|| Main Page | Investor Info | Profile / Divisions | Online Store | Contact Us | | Follow @OmniLiteInd |


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Trip Leader
Phil Salvador
Trip Rating*
Ready to Launch
Duration (hours)
Emergency Phone #s
Latest Expected Departure from beach
1 pm
Auto Description/Lic #
Distance from Houston
30 miles south east
This is an ACA sanctioned event. Every participant must wear a PFD.
Waivers - Please complete our easy to use online waiver if you are a HASK member who has not signed a waiver within the last 12 months or a non- HASK participant. Read the waiver carefully. You give up substantial rights when you sign it.
ACA-HASK Adult Waiver ACA-HASK Minor Waiver
Guests – You are welcome to join us for a couple of paddle trips. HASK will cover the $5 ACA event membership for non-ACA members. Hopefully you will then join HASK and continue paddling with us.


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Your Basket
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This Buschbeck Heavy Duty Cooking Grill is the perfect accessory to complement your Buschbeck Stone BBQ Fireplace.
This Cooking Grill is great for cooking for a large number of people.
Greenfingers, 5 Kingsthorne Park, Houston Ind Estate, Livingston, West Lothian EH54 5DB
©Greenfingers Trading Ltd 2020All rights reserved


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Initiated in December 1985 for the purpose of ensuring that securities are traded in a secure and stable environment, capital market in its modern form has a history of twenty-seven years in Turkey.
Borsa İstanbul markets are organized under four main categories: Equity Market, Debt Securities Market, Precious Metals and Diamond Market and Derivatives Market.
Borsa İstanbul designs different types of indices so as to enable investors to track Borsa İstanbul markets.
Market data, IPO data, monthly consolidated data, market records and information on data dissemination.
Investor Relations refers to the activities aimed at sustaining investor interest in a company through establishing effective communication channels. Investor Relations builds a bridge between the company and the current and potential shareholders; and such bridge has its pillars on providing information on a regular basis and confidence.
Borsa İstanbul Members consist of the intermediary institutions authorized to operate in the capital market.
There are two markets for trading equities on Borsa İstanbul Equity Market and Emerging Companies Market.
Non-publicly-held corporations which issue shares to qualified investors in our Exchange or outside the Exchange without offering to public and existing partners of these corporations, also publicly-held corporations the shares of which are not traded in our Exchange may file an applications for listing of their shares for trading in EMQI. The applications for listing of shares may be acceptable only if and when: a) the issue document is approved by CMB; b) the articles of association of the company does not contain clauses restricting the transfer and circulation of the shares to be traded; c) the company is not subject to significant legal disputes affecting its production and other activities, and it has to be documented by a legal report issued by a lawyer not having any direct or indirect relationship with the corporation that the legal situation of the corporation in terms of its establishment and business operations and the legal situation of its shares are in compliance with the applicable laws and regulations; d) as a result of an assessment made by considering the financial situation and operations of the company, the Board of Directors must have taken a positive decision for trading of shares in EMQI; e) The recent annual and relevant interim period independent audit reports must contain positive opinions.
Existing shareholders of companies, the shares of which are listed in EMQI, may sell their existing shares in this market as of the date of listing.
Real Estate certificates, which are issued for sale to qualified investors, are traded in this market according to the Listing Directive.


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Bringing a new product to market is never easy. It can be a lengthy process, full of rules and regulations before finally launching.
Many brands are easily distracted by the aesthetics of the product, overlooking the importance of ingredients and labelling.
We'll be honest it's not the sexiest part of our job, but believe us when we say, food labelling and packaging regulations are some of the most important aspects of your brand packaging.
Let our team take you through just some of the reasons why…
Don't fight the law
Reason number one, and the most important has to be legislation.
Legally, your packaging will need to show certain information, list ingredients and disclose allergen warnings, all of which may differ depending on which markets you serve.
Incorrect labelling can leave customers with severe health issues and in some extreme cases may even cause death. So, disclosing full ingredients, highlighting allergens and including other important information on your food packaging is paramount.
Just as creative design helps to communicate USPs and differentiate your product, labelling can help to guide consumers on how to use, reuse, recycle or dispose of the product and packaging in a responsible way.
This is especially important for materials that can and should be recycled, as the public become more aware of their sustainability footprint. If you are able to be creative about encouraging re-use and helping your consumers to contribute to a more circular economy it can only have a positive impact for your brand in the long term.
Product recalls
We've all seen the product recall headlines. And for a business, this ain't pretty. Not only does it cost a small fortune to trace, replace or destroy all the mislabelled stock but it can have long-term implications for your brand.
Studies have shown that consumer perception of brand quality and trust can be greatly affected by recalls, not only for the problem product but all other brands in a company's portfolio.
Brand Transparency
As long established suppliers and well-trusted brands hit the headlines, for all the wrong reasons, its only natural to become more distrusting of brands, manufacturers and regulatory bodies. Well publicised product recalls and food scandals only heighten the desire to learn more about the origin of our food and drink.
As consumers become more concerned with complete brand transparency and traceability, accurate labelling becomes ever more important for your packaging.
If you export to various markets, you are likely to face a lot of different labelling regulations. At DCP we can advise you on current regulations and adjust your product's labelling where needed. Feel free to drop us a line if you need to have a chat about food regulations or take a look at our case study here to learn more about how we help brands meet regulations.


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Lately we've been taking Sunday as our day to have breakfast at Loncheria Alexia and Giovanni. Yesterday we were there, and I happened to have my camera with me and took these shots:
Loco waiting patiently for us to eat
They've done some nice renovations to the hotel across the street
No, that's not a person off in the distance, just a t-shirt
Near the end of our meal, a furniture truck pulled up and backed up where those t-shirts were hanging. They started unloading the truck. Then I noticed a large swam of insects in the center of the parking lot. Miguel confirmed that it was a swarm of bees. Loco didn't move, and the people walking through the parking lot stayed calm and the bees did not attack anyone.
The guys unloading the truck suddenly noticed the swarm and stopped what they were doing and walked over and sat on the edge of one of the planters. The swarm gradually moved closer to the truck and that's when we figured out that the truck had disturbed a hive.
Once the swarm calmed down, Miguel went over and carefully took a picture of the hive.
I'm not sure what they'll do about the hive, Miguel seemed to think they'd need to spray. A little scary, but glad it turned out ok.
Monday, December 8, 2008
Our Sunday 'Tradition'
3 comments:
- Life's a Beach! said...
Glad they weren't killer bees! I'd never thought about bees attaching to a palm tree! Loco's such a good boy to sit there in the cart so patiently!
- December 8, 2008 at 9:49 AM
- Ann said...
That could have potentially beeen very bad considering the number of people that eat in the loncherias! My dog would have been over there sticking his nose into it!
- December 8, 2008 at 10:14 AM
- Sue said...
Well, we don't know that they weren't African bees. Hopefully not. And yeah, it could have been a disaster if the bees had turned on everyone nearby. After seeing the size of that swarm and realizing how many bees that must represent, I don't ever want to be in the middle of something like that.
- December 9, 2008 at 9:29 AM
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Mie Hotplate Ceker Saus Padang. Di belakangnya ada Mie Hotplate Daging Sapi Lada Hitam. Harganya sekitar 30-40 ribu. Pizza kayu bakar dengan topping smoked beef. Harganya sekitar 80 ribu. Makanannya enak-enak (enak banget, bukan yang B aja). Cocok buat tempat makan keluarga. Banyak menu lainnya juga. images taken by ibu ❤
Expectation: wake up late, have a slow day Reality: woke up early, took a bath before 6 a.m. At least I got to eat these foods:
Take Care of Our Mental Health
So yesterday was World Mental Health Day. That explained the many posts about this topic these days. Here are my favorites From kak Affi (Female Daily) Thank you ka Affi for the words. I'm doing that, the "taking temporary break", more like shifting my center of life actually. I need some breaks for the shifting […]
Walk to Work
My 2nd time walking to work. Today with mba Ika and Nanda. I took a walk not because the public transportation (angkot) is not operating (because my dad thought so), but for exercising 💪💪 A great thing of working in Bandung, I can walk to work in cool weather and see the greeneries 🌳 Not […]
Hello again hahaha it's been so long. Sorry I have been busy with the wedding preparation (and tried as much to keep the wedding news secret until near the day) Phew~ I have been wanting to write (the draft) so much about the wedding preparation since long. However, that may have to wait because I […]
Cheesecake For Breakfast
Makasih ka Emil 😆😆
Clear Blue Sky
Can you guess where?
Me These Days
Overall, my days have been great 🙂
Eat Fruit
I asked ka Emil to eat fruits & veggies. Then he replied me with this: Yes, currently he likes to play Akinator.
Morning Question
What should I do today to make myself happy? Good foods. Quite & calm commute so I can listen to a podcast. I can read novel. Must finish my work first tho. What else..? [Update] I made this post to remind me to create happiness for myself. Because I think, i'm not supposed to expect […]


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Dear Helen
I've been reading a book whose title makes me cringe but which I've enjoyed; "How to become a Famous Writer Before You're Dead" by Ariel Gore. She talks about how she was at her most productive when she had a small baby, even though she was a solo mother studying, working and fighting family court; she felt such a sense of urgency she had to write something everyday. Then when her daughter started school she wrote at a more leisurely pace from 9-1. Then when she met her partner and he moved in:
Nine A.M. to one P.M. But wouldn't it be nicer to go out to breakfast than to write? Wouldn't it be just as well to sit and talk? I'll write nights, I decided, before I go to bed. Night: The sun sets, painting things orange. My daughter needs help with her homework. She needs to be tucked in, Kiss me good night, Mama. Tell me another story in the dark. At last she's asleep. Or she's not asleep and I leave her with instructions to count porcupines. From the dark of her room to the flickering light of the living room… there's a trashy Lifetime movie on TV and we've got some cheap wine…I take out my contacts and change into my pyjamas, jot a few blurry lines across the top of a yellow legal pad. Should I get my glasses? No. Turn out the light, dear. You can write tomorrow,
And so it goes.
Yes, doesn't that just sum it all up? It's just so easy to let it all slide. Some days I have to force myself, other days I ignore everything because I must get it down on paper. Most importantly I have to be staunch about making time for ME. Not to let the day slip by doing the washing and cooking. Such are the perils of working from home – "Honey can you call the garage (library/lawnmower man/dentist/whatever) since you're home…"
It's one thing having some money and a room of one's own; it's another thing getting past all the daily distractions.
So here's to heads down writing, then onto procrastinating about sending it off for publication – but that's another post!
Love, Helen


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Peruse Pittsburgh's Unique Wedding Veils and Headpieces
Try on our hand-picked array of headpiece options
Swept Away: Kristina Dearfield and Joshua Stein
by Lauren Schmeer | Photograph from Kristen Wynn Photography ——— A little wind and a bit of photographer's magic created this stunning image of Kristina …
Guh-Nosh! Wedding Cakes and Catering
A wedding spread with opulent offerings is hospitable — as creative and celebrity stylist Rachel Zoe might say, it's "mah-jor."
Ring Tones: Engagement and Wedding Rings
Engagement and wedding rings tell everyone that you are committed to someone for life.
Center of Attention: Floral Centerpieces
Captivate the crowd with stunning, show-stopping centerpieces!
Pittsburgh Wedding Planners Offer Wedding Day Advice
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Full Blooms: Wedding Bouquet Inspiration for Every Bride
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With spring (finally) in sight, Executive Head Chef at Sopwell House, Gopi Chandran reveals his recipe for a delicious and nutritious salad to start the season on the right fork
• 4 tbsp olive oil
• 1 large sweet potato, diced
• 2 medium fennel bulbs, cut lengthways into ¼ inch thick slices
• Malden sea salt
• Freshly ground black pepper
• 20ml fresh lemon juice
• 1½ tsp ground cumin
• 1 tsp sugar
• 200g quinoa, rinsed
• 1 lemon
• 1 red chilli, chopped and deseeded
• 10g fresh coriander, chopped
• 10g fresh mint, chopped
• 15g fresh dill, chopped
• Seeds from ½ a small pomegranate
1 Heat 3 tbsp of oil in a large skillet over a medium heat. Add the fennel and season with salt and pepper.
2 Cook for around 10-12 minutes, stirring occasionally, until the fennel is just tender and lightly golden.
3 Add the lemon juice, and sugar. Stir through and cook for a further minute. Season with salt and pepper and set to one side.
4 Preheat the oven to 180∞C. Drizzle the sweet potato with olive oil, sea salt and cumin. Roast in the oven for 10 minutes, and then set aside.
5 Meanwhile, bring the quinoa and 700ml water to a boil in a medium saucepan. Cover and reduce to a low simmer for around 10 minutes until the quinoa is cooked.
6 Drain and return to the pan. Let the quinoa sit in the pan covered for 15 minutes, before fluffing with a fork and transferring to a large bowl.
7 Remove the peel and white pith from the lemon. Cut between the membranes to release the segments. Discard the membranes and roughly chop.
8 Add the chopped lemon with its juices to the cooked quinoa along with the remaining 1 tbsp of oil and stir. Add the fennel mixture, sweet potato, chilli, and herbs.
9 Gently incorporate and season with salt and pepper. Transfer salad to a bowl or platter and sprinkle with pomegranate seeds.
Try it for yourself
Sopwell House, Cottonmill Lane, St Albans, AL1 2HQ


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Beauty: The Gift from the Diaspora
Society loves those Latinas right? How about those Brazilian beauties with the enticing curves, full lips, and perfectly bronzed skin? People are attracted to the "exotic" Latina aesthetic: Large derrière, tanned skin, small waist. But Black girls…not so much. News flash: The very woman society shuns —the Black one—is the one who gave the Latina her curves. Don't credit the child without crediting the parent, right? Yet, that is much of what the public does without being conscious of the depth of it.
The definition of the African Diaspora is the dispersion of African people to places all over the world through voluntary, forced and induced migrations, and did you know that Brazil got over five million of those Africans? Did it ever cross your mind that the physiques that some people drool over are a direct product of the mixing of the Black slaves with European slave owners?
Through miscegenation, these humans—the African, the European and, in some cases, the Indigenous American created one of the most praised, most desired physical forms in this world. The Africans were forced to be slaves in places like Brazil, Colombia, and Puerto Rico, but no one is forced to ignore the genesis of the body type praised so often. People of color already face enough discrimination, and something so simple as acknowledging the black body that is the prototype for a coveted body type, is the least society can do.
In every aspect of every South and Central American culture there are undeniable roots that trace back to Africa. Brazilians are a mixed raced, and it is incorrect, dismissive, and it can be seen as downright offensive to praise Brazilian features without acknowledging the African DNA that is responsible for creating those features. Aside from the gift of physical traits bestowed on the Brazilians, Puerto-Ricans, Cubans, and others, Africa also infused gifts of heritage and cultural customs, which have become traditions for Latin-Americans.
As history has documented, these Africans were raped and forced to endure the unimaginable—just for the production of sugar for places like Brazil. Not only were the Africans stripped of their humanity and happiness, but now, centuries later, they don't even receive respect and credit for their features. These features, once mocked and ridiculed by whites, are now considered desirable and attractive. That is the ironic twist that adds insult to injury.
For instance, Jennifer Lopez is loved and viewed as "#goals" when it comes to identifying the physique of the perfect woman, yet some may ridicule Michelle Obama for the same physical traits. Guess what? Without Michelle Obama's African roots, Jennifer Lopez's incessantly praised backside wouldn't exist. One of the physical aesthetics that many men praise and many women chase is AFRICAN. Do you get it now?


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We didn't get fired! Of course, we didn't expect to. This month we went to ABWE headquarters to have our board interview. This was our first interview with the board besides candidate class back in 2005 and 2007, so we were a little nervous. But the board is so very kind and gracious and everything went very well. We were also up north for the Missionary Enrichment conference. We enjoy seeing our Brazil family and ABWE world family so much. There seemed to be a fight at every meal as to who would hold Anna Claire.
While in Pennsylvania and Virginia (the conference was in Arlington) we were able to see cousins of Sarah and I. My cousin Melanie drove down and I was able to meet her family (she has four kids). Then we stayed at Sarah's cousins Mike and Maria and the two kids that Sarah used to hang out with during some summers, Hannah and Matthew. A big thanks to both for their effort in seeing us!
I am working on a blog for missions. We already have one for our family, but this one is called Trends in Biblical Missions and is intended to open conversation about how we can improve the missions system we now have in the US. I wrote today on Crucial Conversations and how it is easy to take the "sucker's choice" when it comes to having a conversation that is difficult. We like to take the easy way out, but we shouldn't. Pray that this blog can do something for God's glory as sometimes I get discouraged about these little projects I have. If you are interested in being involved in it, please email me.
We opened our accounts today and saw our Outfit and Passage account had doubled! We are now over a third of the way to our one time needed funds for returning to Brazil. These will go mainly towards a car and will also cover passage and moving funds. I checked tickets and found great prices for us for January, but we are looking for people to partner with us financially before we are able to buy tickets. 2 partners at 150/month, 3 partners at 100/month, and 4 partners at 50/month and 4 partners at 25/month should do the trick! Would you pray about being one of these partners? If not a financial partner, the least you can do is come with us! We are still looking for ministry partners for the Brazilian Outback!
This month we head up to Michigan where we will get some family time as well as speak at a friend's (Jeff Selph) youth group. Jeff and I grew up together at Heritage Baptist and it is always neat to continue to serve together! I am also planning on going to Pennsylvania again later in the month for a two day conference for mobilization.
Thanks so much for your continued support of us. God bless you all!
All for HIS glory,
David, Sarah, the energetic runner that sometimes gets car sick and our little roller with a very cute smile.


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Greater Manchester police ran a mock anti-terrorist operation a year ago featuring a bomber shouting in Arabic, "Allahu akbar," or God is great.
But the day after the practice drill, authorities apologized to the city's Muslim community and admitted they had been guilty of stereotyping.
After Monday night's suicide bombing, many Manchester residents praised police, fire and ambulance workers for their rapid response. The 22-year-old suspect in the suicide bombing, for which the Islamic State extremist group claimed responsibility, was described as an English-born son of Libyan immigrants.
Muslim leaders were among those who were quick to condemn the attack, which killed 22 people and wounded dozens, and declare that the city would not be divided.
Mohammed Shafiq, the chief executive of Ramadhan Foundation in Manchester, said in a statement that the deadly explosion after an Ariana Grande concert was the "darkest day" in the city's history.
Shafiq said the people of Manchester would not be divided and would instead "mourn, remember the victims and get on with our lives."
"I love Manchester and its people — we are a resolute people and will not be divided by these barbaric animals or cowered by their violence," he said.


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Cell phone video shows students fighting with CCS bus driver
Cell phone video published on Twitter shows a fist fight between several students and a bus driver at Fort Hayes Metropolitan Education Center.
The incident happened March 9 around dismissal at 2:30 p.m.
According to an incident report filed with Columbus Police, three students assaulted a bus driver. One student was 16-years old, the other two were 17.
The 18-second video starts just outside of a Columbus City School bus on Fort Hayes' campus.
It shows a 53-year-old bus driver going head to head with a student.
The student curses at the driver just before the driver swings toward the student and misses.
Seconds later, another student comes behind the driver and throws a punch at the driver. The driver is then seen falling to the ground.
While the driver is laying on the pavement, several students run toward him and appear to hit him again.
The incident report says the driver suffered minor injuries.
Columbus City school officials say the bus driver involved in this incident was taken off the road Monday.
It is unclear if or how the driver and/or students will be reprimanded.


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Longtime NBA coach lays into Knicks star as user of people, addicted to the spotlight in forthcoming book
Longtime NBA coach George Karl blasted New York Knicks star Carmelo Anthony in a memoir set to be released next month, calling the nine-times NBA all-star a true conundrum and a user of people, addicted to the spotlight.
Karl, who coached Anthony with the Denver Nuggets from January 2005 until February 2011, spared no criticism of his former charge, who in August became the first ever three-times Olympic gold medalist in mens basketball.
Carmelo was a true conundrum for me in the six years I had him, Karl wrote in an advance copy of Furious George: My Forty Years Surviving NBA Divas, Clueless GMs, and Poor Shot Selection that was obtained by the New York Post. He was the best offensive player I ever coached. He was also a user of people, addicted to the spotlight and very unhappy when he had to share it.
Added Karl: He really lit my fuse with his low demand of himself on defense. He had no commitment to the hard, dirty work of stopping the other guy.
My ideal probably every coachs ideal is when your best player is also your leader. But since Carmelo only played hard on one side of the ball, he made it plain he couldnt lead the Nuggets, even though he said he wanted to. Coaching him meant working around his defense and compensating for his attitude.
Karl, one of only nine NBA coaches with more than 1,000 career victories, described an organization-wide sense of relief when the Nuggets finally accommodated Anthonys persistent request for a trade out of Denver in 2011, calling it a sweet release for the coach and the team, like popping a blister.
I want as much effort on defense maybe more as on offense, Karl wrote. That was never going to happen with Melo, whose amazing ability to score with the ball made him a star but didnt make him a winner. Which I pointed out to him. Which he didnt like.
The 65-year-old former coach also criticized JR Smith and Kenyon Martin, two of Anthonys team-mates in Denver, likening them to the spoiled brats you see in junior golf and junior tennis and referencing the trio collectively as AAU babies.
Karl, who was fired from his most recent coaching post with Sacramento at the end of last season, amassed a career record of 1,175-824 in stints with the Kings, Nuggets, Milwaukee Bucks, Seattle Supersonics, Golden State Warriors and Cleveland Cavaliers.
Read more: https://www.theguardian.com/sport/2016/dec/22/george-karl-memoir-carmelo-anthony


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A Supreme Decision
I will never be a Supreme Court Justice. Of course there is the obvious issue of me not being a lawyer, but also I'd never survive the confirmation process. No, there are no life altering skeletons in my closet, but my attitude is not one that would allow me to sit by and defend everything I've done, publically and privately, in my lifetime. I have no desire to go through that scrutiny. Do I really need them parading around transcripts of conversations I had when I was twenty-three? At the end of the day should anyone really care how many personal copies I made at work or how many two-hour lunches I took in my career?
As we gear up to watch the confirmation broo-ha-ha that will surround Sonia Sotomayor, I'm wondering what's it all for? Yes, we need to make sure she's qualified, but a judge is a judge is a judge. You don't rise in the ranks of the Appellate Courts if you're taking kick backs or drinking on the job. In Corporate America you can rise to CEO status all the while embezzling funds, smoking crack on conference calls and sleeping with your subordinates in the break room…in the court of appeals, not so much! I wonder if she were an old fogey (translation: conservative white man) would the Limbaugh's and Hannity's of the world be so quick to rally against her.
If she were not competent she never would have been confirmed as a federal judge. We know this is not about competence. When a President nominates a candidate for the Supreme Court he does so knowing that if confirmed, this person will probably sit on the bench for many years, and the decisions they rule on will always reflect back on him, long after his presidency ends. A president won't knowingly nominate a candidate he knows is going to try to interpret the constitution in a way that directly contradicts his own views. Let's be honest, would you hire a Voodoo priestess to babysit your kids if you were a devout Christian? While no President can guarantee how a justice will vote, you look at their past rulings and take a leap of faith that they won't shock and disappoint. The issue of remarks she made in the past that have the conservative talk radio nit-wits calling her a racist will hopefully blow over. If it doesn't and she steps down, I'm sure the next candidate President Obama nominates will undergo the same scrutiny.
At the end of the day Democrats have the numbers, so they can and will approve President Obama's nominee. Republican's have to walk a fine line because while they would love a conservative anti-abortion, anti-affirmative action, anti gay rights justice, they can't very well say that out loud.
As we have just seen our nations first Black President give us a guided tour of the White House, shouldn't we also be ready to see a Latina Woman wearing that black robe?
2 Comments »
Two hour lunches would definitely haunt my confirmation hearings as well! 🙂 I heard something yesterday that really galled me on this issue. I don't even know who it was but it was some guest on an MSNBC show talking about how the real fact at hand is that they need to find out if she is going to be able to make her decisions by the rule of law and not with her heart. And it irked me because it was a generalization made just because she is a woman, it wasn't even narrowing in on the views it was just a broad generalization of her status as a woman. That question would not even come up for a man.
Comment by ncmama | June 4, 2009
The republicans will continue to pull at any string they can find in order to discredit this administration.
the truth of the matter, is President Obama as made it an open door and allowed for all critics to do with they do in the open. What these critics don't realize, very soon, oh so very soon, they will be really exposing themselves.
You see we already know they are racist, we know they are cheaters and we know they are "hustlers." Soon they will talk so much they will tell on themselves and then we can all sit back and watch as they scrabble to pick their faces off the floor.
They better be careful because soon they are going to have to turn the light on in order to find dirt and the dirt is going to be theirs.
Comment by Venom Patton | June 4, 2009


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girl using twister
Video of girl using trojan vibrating.
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The hair of African American girls is known to be very voluminous and swell, and this fact makes it pretty hard to get the right hairstyle. Fortunately, there several
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In this video, we learn how to do a twist ponytail on an American Girl doll. First, you will want to brush out the doll's hair until it's straight and free of knots.
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Over the last two years Ariel Winter has gone from being a teenager to a woman, but there is something childlike that she does that freaks people out. She told Conan O'Brien on his TBS talk show yesterday, that her baby voice makes her boyfriend and her friends really uncomfortable.
How and why? The host asked her to do it and you can judge for yourself how and why it does that. Personally, I find it more annoying than uncomfortable. What will really make people uncomfortable is in 10 years when she does her Sofia the First around teen boys, who will be all types of confused. Childhood memory gone wrong because a sexy woman sounds like a character they really loved in preschool. How creepy would that be?


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MONROE - The Monroe Parks and Recreation Department is hosting an afternoon of volleyball from 1 to 3 p.m. Tuesday, Oct. 28 at the Monroe High School gymnasium. This activity is being offered to fourth through eighth grade girls and boys. Participants will go through a variety of different drills with the MHS varsity players.
Volleyball event is Tuesday


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Aging and lipotoxicity are two major risk factors for gout that are linked by the activation of the NLRP3 inflammasome. Neutrophil-mediated production of interleukin-1 beta (IL-1 beta) drives gouty flares that cause joint destruction, intense pain, and fever. However, metabolites that impact neutrophil inflammasome remain unknown. Here, we identified that ketogenic diet (KD) increases beta-hydroxybutyrate (BHB) and alleviates urate crystal-induced gout without impairing immune defense against bacterial infection. BHB inhibited NLRP3 inflammasome in S100A9 fibril-primed and urate crystal-activated macrophages, which serve to recruit inflammatory neutrophils in joints. Consistent with reduced gouty flares in rats fed a ketogenic diet, BHB blocked IL-1 beta in neutrophils in a NLRP3-dependent manner in mice and humans irrespective of age. Mechanistically, BHB inhibited the NLRP3 inflammasome in neutrophils by reducing priming and assembly steps. Collectively, our studies show that BHB, a known alternate metabolic fuel, is also an anti-inflammatory molecule that may serve as a treatment for gout.
Alpha-synuclein (α-syn) toxic aggregates delivered by the nasal vector have been shown to modify the neurochemistry of dopamine (DA) which is associated with parkinsonian-like motor symptoms. The aim was therefore to study the intranasal effects of α-syn oligomers, fibrils or their combination on the motor behavior of aged mice in relation to possible noradrenergic and serotonergic correlates. In vitro generated α-syn oligomers and fibrils were verified using atomic force microscopy and the thioflavin T binding assay. Levels of noradrenaline (NA), serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were detected using HPLC with electrochemical detection in the substantia nigra (SN) and striatum. The oligomers or fibrils administered alone or in a 50:50 combination (total dose of 0.48mg/kg) were given intranasally for 14 days and "open-field" behaviour was tested on days 0, 15 and 28 of the protocol, at which time brain structures were sampled. Behavioral deficits at the end of the 14-day dosing regime and on day 28 (i.e. 14 days after treatment completion) induced hypokinesia and immobility whilst the aggregate combination additionally produced rigidity. The α-Syn oligomer/fibril mixture also instigated PD-like motor symptoms which correlated heterochronically with elevated NA levels in the striatum but then later in the SN while intranasal fibrils alone augmented 5-HT and 5-HIAA nigral concentrations throughout the protocol. In contrast, α-syn oligomers displayed a delayed serotonin upsurge in the SN. Neurodegenerative and/or actions on neurotransmitter transporters (such as NET, SERT and VMAT2) are discussed as being implicated in these α-syn amyloid induced neurochemical and motoric disturbances.
Parkinson's disease (PD) is a neurodegenerative disorder in which both alpha-synuclein (alpha-syn) and dopamine (DA) have a critical role. Our previous studies instigated a novel PD model based on nasal inoculation with alpha-syn aggregates which expressed parkinsonian-like behavioral and immunological features. The current study in mice substantiated the robustness of the amyloid nasal vector model by examining behavioral consequences with respect to DA-ergic neurochemical corollaries. In vitro generated alpha-syn oligomers and fibrils were characterized using atomic force microscopy and the thioflavin T binding assay. These toxic oligomers or fibrils administered alone (0.48 mg/kg) or their 50:50 combination (total dose of 0.48 mg/kg) were given intranasally for 14 days and "open-field" behavior was tested on days 0, 15 and 28 of the protocol. Behavioral deficits at the end of the 14-day dosing regime and on day 28 (i.e., 14 days after treatment completion) induced rigidity, hypokinesia and immobility. This was accompanied by elevated nigral but not striatal DA, DOPAC and HVA concentrations in response to dual administration of alpha-syn oligomers plus fibrils but not the oligomers by themselves. alpha-Syn fibrils intensified not only the hypokinesia and immobility 14 days post treatment, but also reduced vertical rearing and enhanced DA levels in the substantia nigra. Only nigral DA turnover (DOPAC/DA but not HVA/DA ratio) was augmented in response to fibril treatment but there were no changes in the striatum. Compilation of these novel behavioral and neurochemical findings substantiate the validity of the alpha-syn nasal vector model for investigating parkinsonian-like symptoms.
(C) 2014 Elsevier B.V. All rights reserved.
Memory deficits may develop from a variety of neuropathologies including Alzheimer's disease dementia. During neurodegenerative conditions there are contributory factors such as neuroinflammation and amyloidogenesis involved in memory impairment. In the present study, dual properties of S100A9 protein as a pro-inflammatory and amyloidogenic agent were explored in the passive avoidance memory task along with neurochemical assays in the prefrontal cortex and hippocampus of aged mice. S100A9 oligomers and fibrils were generated in vitro and verified by AFM, Thioflavin T and All antibody binding. Native S100A9 as well as S100A9 oligomers and fibrils or their combination were administered intranasally over 14 days followed by behavioral and neurochemical analysis. Both oligomers and fibrils evoked amnestic activity which correlated with disrupted prefrontal cortical and hippocampal dopaminergic neurochemistry. The oligomer-fibril combination produced similar but weaker neurochemistry to the fibrils administered alone but without passive avoidance amnesia. Native S100A9 did not modify memory task performance even though it generated a general and consistent decrease in monoamine levels (DA, 5-HT and NA) and increased metabolic marker ratios of DA and 5-HT turnover (DOPAC/DA, HVA/DA and 5-HIAA) in the prefrontal cortex. These results provide insight into a novel pathogenetic mechanism underlying amnesia in a fear-aggravated memory task based on amyloidogenesis of a pro-inflammatory factor leading to disrupted brain neurochemistry in the aged brain. The data further suggests that amyloid species of S100A9 create deleterious effects principally on the dopaminergic system and this novel finding might be potentially exploited during dementia management through a neuroprotective strategy.
Background: Chronic neuroinflammation is a hallmark of Parkinson's disease (PD) pathophysiology, associated with increased levels of pro-inflammatory factors in PD brain tissues. The pro-inflammatory mediator and highly amyloidogenic protein S100A9 is involved in the amyloid-neuroinflammatory cascade in Alzheimer's disease. This is the first report on the co-aggregation of alpha-synuclein (alpha-syn) and S100A9 both in vitro and ex vivo in PD brain.
Methods: Single and sequential immunohistochemistry, immunofluorescence, scanning electron and atomic force (AFM) microscopies were used to analyze the ex vivo PD brain tissues for S100A9 and alpha-syn location and aggregation. In vitro studies revealing S100A9 and alpha-syn interaction and co-aggregation were conducted by NMR, circular dichroism, Thioflavin-T fluorescence, AFM, and surface plasmon resonance methods.
Results: Co-localized and co-aggregated S100A9 and alpha-syn were found in 20% Lewy bodies and 77% neuronal cells in the substantia nigra; both proteins were also observed in Lewy bodies in PD frontal lobe (Braak stages 4-6). Lewy bodies were characterized by ca. 10-23 mu m outer diameter, with S100A9 and alpha-syn being co-localized in the same lamellar structures. S100A9 was also detected in neurons and blood vessels of the aged patients without PD, but in much lesser extent. In vitro S100A9 and alpha-syn were shown to interact with each other via the alpha-syn C-terminus with an apparent dissociation constant of ca. 5 mu M. Their co-aggregation occurred significantly faster and led to formation of larger amyloid aggregates than the self-assembly of individual proteins. S100A9 amyloid oligomers were more toxic than those of alpha-syn, while co-aggregation of both proteins mitigated the cytotoxicity of S100A9 oligomers.
Conclusions: We suggest that sustained neuroinflammation promoting the spread of amyloidogenic S100A9 in the brain tissues may trigger the amyloid cascade involving alpha-syn and S100A9 and leading to PD, similar to the effect of S100A9 and A beta co-aggregation in Alzheimer's disease. The finding of S100A9 involvement in PD may open a new avenue for therapeutic interventions targeting S100A9 and preventing its amyloid self-assembly in affected brain tissues.
Pro-inflammatory protein S100A9 was established as a biomarker of dementia progression and compared with others such as Aβ1-42 and tau-proteins. CSF samples from 104 stringently diagnosed individuals divided into five subgroups were analyzed, including nondemented controls, stable mild cognitive impairment (SMCI), mild cognitive impairment due to Alzheimer's disease (MCI-AD), Alzheimer's disease (AD), and vascular dementia (VaD) patients. ELISA, dot-blotting, and electrochemical impedance spectroscopy were used as research methods. The S100A9 and Aβ1-42 levels correlated with each other: their CSF content decreased already at the SMCI stage and declined further under MCI-AD, AD, and VaD conditions. Immunohistochemical analysis also revealed involvement of both Aβ1-42 and S100A9 in the amyloid-neuroinflammatory cascade already during SMCI. Tau proteins were not yet altered in SMCI; however their contents increased during MCI-AD and AD, diagnosing later dementia stages. Thus, four biomarkers together, reflecting different underlying pathological causes, can accurately differentiate dementia progression and also distinguish AD from VaD.
Amyloid formation and neuroinflammation are major features of Alzheimer's disease pathology. Proinflammatory mediator S100A9 was shown to act as a link between the amyloid and neuroinflammatory cascades in Alzheimer's disease, leading together with Aβ to plaque formation, neuronal loss and memory impairment. In order to examine if S100A9 alone in its native and amyloid states can induce neuronal stress and memory impairment, we have administered S100A9 species intranasally to aged mice. Single and sequential immunohistochemistry and passive avoidance behavioral test were conducted to evaluate the consequences. Administered S100A9 species induced widespread cellular stress responses in cerebral structures, including frontal lobe, hippocampus and cerebellum. These were manifested by increased levels of S100A9, Box, and to a lesser extent activated caspase-3 immunopositive cells. Upon administration of S100A9 fibrils, the amyloid oligomerization was observed in the brain tissues, which can further exacerbate cellular stress. The cellular stress responses correlated with significantly increased training and decreased retention latencies measured in the passive avoidance test for the SI00A9 treated animal groups. Remarkably, the effect size in the behavioral tests was moderate already in the group treated with native S100A9, while the effect sizes were large in the groups administered S100A9 amyloid oligomers or fibrils. The findings demonstrate the brain susceptibility to neurotoxic damage of S100A9 species leading to behavioral and memory impairments. Intranasal administration of S100A9 species proved to be an effective method to study amyloid induced brain dysfunctions, and 5100A9 itself may be postulated as a target to allay early stage neurodegenerative and neuroinflammatory processes.
Background Traumatic brain injury (TBI) is a complex disease with a spectrum of symptoms and disabilities. Over the past decade TBI has become the focus of research due to growing epidemiological and clinical evidences that TBI incidences are strong risk factors for Alzheimer's disease (AD). Major pathological hallmarks of AD are massive accumulations of amyloid-β peptide (Aβ) toxic oligomers and plaques. Neuroinflammation is also considered as a common denominator in AD and aging. The epidemiological and experimental studies have supported that non-steroidal anti-inflammatory drugs markedly reduce the age-related prevalence of AD and can slow amyloid deposition by mechanisms that still remain elusive. S100A9 is a multifunctional cytokine with diverse roles in the cell signaling pathways associated with inflammation and cancers. A widespread expression of S100A9 was also reported in many other ailments involving inflammatory processes, such as AD, malaria, cerebral ischemia and TBI, implying that S100A9 may be a universal biomarker of inflammation. The distinctive feature of S100A9 compared to other pro-inflammatory cytokines is its ability to self-assemble into amyloids, which may lead to the loss of its signaling functions and acquired amyloid cytotoxicity, exceeding that of Aβ.
Methods S100A9 properties was studied under various ex vivo and in vitro conditions. First, human and mouse tissues with TBI and AD were subjected to microscopic, immunohistochemical and immunofluorescent techniques. Then, aged mouse treated with native, oligomeric and fibrillary S100A9 was also studied by using behavioral and neurochemical analysis. Moreover, S100A9 was established as a biomarker of dementia progression and compared with others such as Aβ42 and tau proteins, by studying cerebrospinal fluid (CSF) samples from different stages of dementia. Finally, in vitro experiments on S100A9 amyloidogenesis, co-aggregation with Aβ40 and Aβ42, digestion and cytotoxicity were also performed by using spectroscopic, atomic force microscopy and cell biology methods.
Results S100A9-driven amyloid-neuroinflammatory cascade serves as a link between TBI and AD. We have found that S100A9 contributes to the plaque formation and intraneuronal responses in AD, being a part of the amyloid-neuroinflammatory cascade. In TBI we have found that extensive S100A9 neuronal production and amyloid self-assembly is triggered immediately after injury, leading to apoptotic pathways and neuronal loss. S100A9 is an integral component of both TBI precursor-plaques, formed prior to Aβ deposition, and AD plaques, characterized by different degree of amyloid maturation, indicating that all plaques are associated with inflammation. Both intra- and extracellular amyloid-neuroinflammatory cascades are intertwined and showed similar tendencies in human and mouse tissues in TBI and AD. Ex vivo findings are further supported by in vitro experiments on S100A9 amyloidogenesis, digestion and cytotoxicity. Importantly, being highly amyloidogenic itself, S100A9 can trigger and aggravate Aβ amyloid self-assembly and significantly contribute to amyloid cytotoxicity. Moreover, the CSF dynamics of S100A9 levels matches very closely the content of Aβ42 in AD, vascular dementia and mild cognitive impairment due to AD, emphasizing the involvement of S100A9 together with Aβ in the amyloid-neuroinflammatory cascade in these ailments.
Conclusions The conclusions of this thesis is that the inflammatory pathways and S100A9 specifically represent a potential target for the therapeutic interventions during various post-TBI stages and far prior AD development to halt and reverse these damaging processes.
Traumatic brain injury (TBI) represents a significant risk factor for development of neurodegenerative diseases such as Alzheimer's and Parkinson's. The S100A9-driven amyloid-neuroinflammatory cascade occurring during primary and secondary TBI events can serve as a mechanistic link between TBI and Alzheimer's as demonstrated recently in the human brain tissues. Here by using immunohistochemistry in the controlled cortical impact TBI mouse model we have found pro-inflammatory S100A9 in the brain tissues of all mice on the first and third post- TBI days, while 70% of mice did not show any S100A9 presence on seventh post-TBI day similar to controls. This indicates that defensive mechanisms effectively cleared S100A9 in these mouse brain tissues during post-TBI recovery. By using sequential immunohistochemistry we have shown that S100A9 was produced by both neuronal and microglial cells. However, A beta peptide deposits characteristic for Alzheimer's disease were not detected in any post-TBI animals. On the first and third post-TBI days S100A9 was found to aggregate intracellularly into amyloid oligomers, similar to what was previously observed in human TBI tissues. Complementary, by using Rayleigh scatting, intrinsic fluorescence and atomic force microscopy we demonstrated that in vitro S100A9 self- assembles into amyloid oligomers within minutes. Its amyloid aggregation is highly dependent on changes of environmental conditions such as variation of calcium levels, pH, temperature and reduction/oxidation, which might be relevant to perturbation of cellular and tissues homeostasis under TBI. Present results demonstrate that S100A9 induction mechanisms in TBI are similar in mice and humans, emphasizing that S100A9 is an important marker of brain injury and therefore can be a potential therapeutic target.
Pro-inflammatory and amyloidogenic S100A9 protein is an important contributor to Alzheimer's disease (AD) pathology. Traumatic brain injury (TBI) is viewed as a precursor state for AD. Here we have shown that S100A9-driven amyloid-neuroinflammatory cascade was initiated in TBI and may serve as a mechanistic link between TBI and AD. By analyzing the TBI and AD human brain tissues, we demonstrated that in post-TBI tissues S100A9, produced by neurons and microglia, becomes drastically abundant compared to A beta and contributes to both precursor-plaque formation and intracellular amyloid oligomerization. Conditions implicated in TBI, such as elevated S100A9 concentration, acidification and fever, provide strong positive feedback for S100A9 nucleation-dependent amyloid formation and delay in its proteinase clearance. Consequently, both intracellular and extracellular S100A9 oligomerization correlated with TBI secondary neuronal loss. Common morphology of TBI and AD plaques indicated their similar initiation around multiple aggregation centers. Importantly, in AD and TBI we found S100A9 plaques without A beta. S100A9 and A beta plaque pathology was significantly advanced in AD cases with TBI history at earlier age, signifying TBI as a risk factor. These new findings highlight the detrimental consequences of prolonged post-TBI neuroinflammation, which can sustain S100A9-driven amyloid-neurodegenerative cascade as a specific mechanism leading to AD development.
Pro-inflammatory S100A9 protein is increasingly recognized as an important contributor to inflammation-related neurodegeneration. Here, we provide insights into S100A9 specific mechanisms of action in Alzheimer's disease (AD). Due to its inherent amyloidogenicity S100A9 contributes to amyloid plaque formation together with A beta. In traumatic brain injury (TBI) S100A9 itself rapidly forms amyloid plaques, which were reactive with oligomer-specific antibodies, but not with A beta and amyloid fibrillar antibodies. They may serve as precursor-plaques for AD, implicating TBI as an AD risk factor. S100A9 was observed in some hippocampal and cortical neurons in TBI, AD and non-demented aging. In vitro S100A9 forms neurotoxic linear and annular amyloids resembling A beta protofilaments. S100A9 amyloid cytotoxicity and native S100A9 pro-inflammatory signaling can be mitigated by its co-aggregation with A beta, which results in a variety of micron-scale amyloid complexes. NMR and molecular docking demonstrated transient interactions between native S100A9 and A beta. Thus, abundantly present in AD brain pro-inflammatory S100A9, possessing also intrinsic amyloidogenic properties and ability to modulate A beta aggregation, can serve as a link between the AD amyloid and neuroinflammatory cascades and as a prospective therapeutic target.
Inflammation is one of the prominent pathological features in Alzheimer's disease (AD). Recently, there have been various proposed roles of neuroinflammation, such as the driving forces, bystander, byproduct or the neuroprotective response. Notwithstanding these diverse possible mechanisms, experiments have found that S100A9 is one of the pro-inflammatory proteins abundant and over-expressed in the inflammation sites of AD. In this paper, we examine the role of S100A9 in the oligomerization process of A beta peptides by means of replica exchange molecular dynamics simulation and experimental investigations. Our experiments, based on atomic force microscopy and Thioflavin T spectroscopic assays, have clearly indicated that the close interaction between S100A9 and A beta has significantly enhanced the A beta oligomerization. In line with the experimental observation, our simulation studies have revealed that the pro-inflammatory S100A9 protein interacts with the A beta peptides directly, mainly through hydrophobic interactions with the A beta central hydrophobic core region. In addition, the formation of hydrogen bonds between the residues of the S100A9 homodimer and the two ends of the A beta peptides is found to cause a straightening of the A beta(12-24) peptides. A more straight A beta(12-24) peptide with a higher beta-content then may function as a template to induce the folding of new incoming A beta peptides, which leads to the formation of aggregation-prone oligomers.


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The law college tuition fee within the Philippines often ranges from forty,000 pesos or extra per semester, relying on the college. Very very long time, no see! Thanks for studying and commenting! It's onerous to change the mind of a Leo! It is gratifying for me when people read my interpretation and feel it's correct. Take care.
The selection whether or not or not or to not go to law college ought to be multi-faceted. Worth, time, and potential income must all be thought-about. It might be a couple of years (if not a few years) before you recoup your funding in larger education. I hope you'll be obtainable for me immediately earlier than I arrive, it undoubtedly can act as a gentle basis to our impending working relationship.
Disclosure to any occasion apart from the addressee, whether inadvertent or in some other case, should not be intended to waive privilege or confidentiality. The Pennsylvania and National Oil Heritage Areas embody a total of over seven hundred sq. miles of land and dozens of communities. Financial progress and setting security are major objectives in this mixed area.
A Frequent Wage? I agree the disparity between wealthy and poor is just too nice, nevertheless how did it get that method? How about taking money out of the system and having all people (together with CEOs) contribute their talent and obtain meals, clothing, shelter and medical care? Each era has its personal economic system. We must always find our manner in it.


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Big B slams slumdog millionaire
Superstar Amitabh Bachchan has criticised Slumdog Millionaire, the Golden-Globe winning movie which tells the rags-to-riches tale of an orphan from a Mumbai slum, for portraying India as a "Third World dirty underbelly developing nation"."It's just that the SM (Slumdog Millionaire) idea authored by an Indian and conceived and cinematically put together by a Westerner, gets creative Globe recognition. The other would perhaps not," Bachchan wrote on his blog.
If the movie projects "India as a third world dirty underbelly developing nation and causes pain and disgust among nationalists and patriots, let it be known that a murky underbelly exists and thrives even in the mostdeveloped nations."
"Conditions world over are so similar. Perceptions differ, but the reality of life and existence, unchanged. Comments for the film Slumdog Millionaire and the anger by some on its contents, prompt me to say the above," Bachchan wrote.Bachchan recalled that the "commercial escapist world of Indian cinema" has vociferously battled for years, on the attention paid and adulation given to legendary Satyajit Ray at all prestigious film festivals of the West and not a word of appreciation for the entertaining mass-oriented box office blockbusters that were being churned out from Mumbai.
"The argument: Ray portrayed reality. The other escapism, fantasy and incredulous posturing. Unimpressive for Cannes, Berlin and Venice. But look at how rapidly all that is changing," he said.Actor Irrfan Khan, who plays a police inspector in Slumdog Millionaire, has rejected criticism about the film and believes the reality of Indian poverty can't be ignored.


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Last night I went to my school Xmas dance in a big, fancy hotel. I arrived earlier than my friends so I had to walk in and just drift around making small talk with people. I was friendly but people kept ignoring at me and pointing at me. I have never felt so embarrassed and lonely in my life. Everyone was getting photos together and there was me standing in a corner no one bothering to talk to me and me trying not to cry. I eventually left and went and found a chair to sit on and cried my eyes out - I just want to be normal. I thought I could go to that dance and be a normal teenage girl for one night but no. I eventually had to go home because I just couldn't stand it. I was just wondering if anyone had any advice? I am feeling awful today and just wanting to hide and never face my school again, but I have mock exams soon so I have to study but my mental health is really poor right now. I am also feeling slightly angry that no one thought to even just say hi to me or even ask to join them, which was the way I was raised. I try so hard but I just keep getting things wrong. I go to a very academic school and the pressure they put on me is insane. The teachers were all angry at me for leaving and I feel so awful for wasting my mums hard earned money on that stupid dance.
Sorry this was more of a rant!
Any comments or advice would be greatly appreciated x
I am in my late 20s now but I can definitely understand how you feel. You should be proud of yourself for even trying to go to the dance. I wouldn't have even been able to get that far when I was your age. I had a similar experience at a wedding this year. No one tried to speak to me, even the people I knew well left me feeling awkward. People just told me to stop looking so miserable. It wasn't a nice experience.
I think it's awful your teachers were angry, they should be understanding. Try to move on from it though and remember you have lots of strengths and talents that those other people probably don't have.
Don't always feel you have to do things because it's the "norm". It's ok to say actually I don't want to do that and to do something you like and are comfortable with instead.
As a mid fifties Male I too can relate to not being seen or talked to,
when we were waiting to go home yesterday it being our last day working for Xmas, I was in the main office stood there wondering why everyone was acting like no one would ever see one another again?
it is a ritual I can see no sense in st all, we will be returning back to work after Xmas!
the loud voices, the inevitable hugs and loud laughter, eating a little buffet laid on by The bosses, No one came to talk to me, yes I got the odd " alright how are you" and " have a good Xmas mate".
I felt awkward, the noise and bustle all around me, I just stood there looking on, I began to feel anxious as I did not know quite how to join in, these are men and staff I work with every day, no one was leaving bar one secretary who was the main focus of attention. Even then it was way over the top emotion for being sad she was leaving or jokes about thank god for that, don't rush back to soon,,,,Lol.
I wanted to get out, but stayed as long as I thought was polite.
As the others have said, be kind to yourself and don't think you must attend such things if it will effect you to much. Peer pressure is a big thing to cope with, if needs be make a polite excuse and do something that fills your life with happiness.
It is sad when you work so hard to be part of it and no one seems to want to join with you, story of my life.
take care and good luck with the mock exams. I am sure you will do well.


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Clincs in the Modern School of the Italian Sword
Part of the mission of the North American Mangiarotti Society is to conduct clinics to train fencers and fencing coaches in the Mangiarotti technique. To that end we are developing a standard clinic curriculum which may be used for coaching clinics and for clinics for fencers. Arrangements between a clinic host and the fencing master are the responsibility of the two parties; the North American Mangiarotti Society provides this listing as a service to its members, and does not assume responsibility for the conduct of clinics or their outcome.
Fencing Coaches Offering Clinics
The following Fencing Masters authorized by the Circolo della Spada Mangiarotti to teach the Modern School of the Italian Sword conduct clinics in the Mangiarotti technique:
Maestro di Scherma Stuart Kaufman offers multiple day clinics for fencing coaches on the Mangiarotti Technique, anywhere in the United States. To contact him about presenting a clinic, please use the contact box for coaching clinics on the right side of this page.
Maitre d'Armes Walter Green teaches one day or half day short clinics on the Mangiarotti technique for fencers in foil, sabre, or epee. To inquire about a fencer clinic in North Carolina or Virginia, please use the contact box for fencing clinics on the right side of this page.
Specific details on individual clinics will be posted on FRED. Clinics will be listed based on the Division of the hosting Salle or Club.
April 2017 (date to be set) - Mangiarotti Foil Technique - 1 day clinic - at Salle Green, Glen Allen, Virginia.
September 2017 (date to be set) - Mangiarotti Epee Technique - 1 day clinic - at Salle Green, Glen Allen, Virginia


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One Mini to rule them all: The MINI One
Ever since BMW took on the classic brand people have been questioning the update. God only knows why!
There are plenty of classic MINI fans out there today who dissaprove of the larger, more German model. But there is plenty to like in this stylish update that brings a gem of automotive history into the world of the modern hatchback. Alongside being a market leader in performance and practicality, this MINI clearly looks fantastic and can still hold its own with its aged relatives. As a German model you won't be breaking down every five minutes either, which is nice!


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Barry Cowen says Brian will inspire FF bid for three seats in Laois-Offaly
FOLLOWING on from their encouraging opening round performance against Wexford in O'Connor Park last Saturday, the Offaly minor hurlers will make the trip to Parnell Park on Saturday (2pm) to take on Dublin in the hope of not only putting in a similar performance but also picking up their first Leinster championship points.
Wexford finished the game stronger last weekend with a goal five minutes from time putting them in pole position but there was plenty for the Offaly camp to be positive about.
Dublin will also be looking for their first points of the campaign having been edged out by a last minute point against Kilkenny last Saturday.
It will be another stiff test for the Offaly men as they compete in tier one of the championship this year.
In a group with Wexford, Dublin and Kilkenny, where they finish in the group will determine which of the teams from the other groups they will face in the knockout stages.
Having come so close to beating Wexford, there will be no shortage of motivation to go out and try and go one better this Saturday.
They only scored 1-4 in the second half against Wexford and this was with a strong wind behind them while only three of their 11 points in total came from play. This is evidence that despite their good performance, there is still room for improvement.
Dublin will go into the game as favourites but Offaly, unlike other years when coming up against the big counties at minor level, have a real chance. They won't sit back and look to keep the damage to a minimum as proven last Saturday. They went out, had a cut and came up short and there is no shame in that.
Expect them to have another cut off one of the big guns this Saturday.


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DOI: https://doi.org/10.33546/bnj.509
Background: Tuberculosis (TB) is the major global health problem. A high number of TB cases are as a result of the disease spreads through droplet nuclei which mainly through a cough. TB transmission prevention is really important to lower the rate of new infection. Since TB transmission is through a cough, therefore, one of the preventions behaviour is implementing the good and right cough etiquette. In 2016 there were 425 TB patients in Sub-District Rancaekek and was the higher number in District of Bandung. The aim of this study was to find out the overview of knowledge, attitude and practice of cough etiquette in tuberculosis patients.
Objectives: The aim of this study was to find out the overview of knowledge, attitude and practice of cough etiquette in tuberculosis patients.
Methods: This study was descriptive quantitative with the cross sectional approach, the population were all Acid-Fast Bacillus (AFB) + TB patients that were registered in the primary health care Rancaekek, Linggar and Nanjung Mekar amount of 52 people and used total sampling. The data collection technique used a questionnaire to measure knowledge and attitude, and observation sheet to measure practice that was valid and reliable. The used data analysis was frequency distribution, mean and median.
Results: The results of this study indicated that from 52 respondents, more than half of them had good knowledge about cough etiquette (65.4%, median value 83.33 and IQR 20), more than half of them had negative cough etiquette attitude (51.9%, mean value 47.87 and SD 5.885) and more than half of them had bad practice in cough etiquette (63.5%, median value 5 and IQR 2).
Conclusions: The result of this study is expected to become an overview for primary health care in doing improvement in delivering education to TB patients and their families about the good and right cough etiquette which is focused on the affective and psychomotor aspects, such as lectures, leaflet distribution, and live right and good cough etiquette simulation, so that it can prevent the spread of TB and decrease the rate of TB infection.
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