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I don't know why I waited so long to try making bone broth (also, I had never tasted it before, but that's another subject entirely). It could be because I had never seen any sort of marrow bones at the grocery store…and to be entirely honest, boiling a pot of bones and water didn't sound all that appealing to me. Before I made this broth, I had made chicken broth a total of one time. I just always sort of forgot about making broth every time we ate a chicken…which is funny because I roast a chicken pretty much once a week. That's a lot of broth I could have made!
What health benefits do we get from bone broth? Well, from the marrow of the bone, we boost our immune systems, boost blood cell function, and reap the benefits of additional collagen, gelatin, magnesium, potassium, calcium, and myriad other good things that our bodies need. The nutrients in bone broth help your body build connective tissue, suppress inflammatory activity, and increase hair, skin, and nail health. Yes, it even helps to tighten loose skin! Bones with more marrow (i.e. the larger bones) are good to use if you want more cellular repair and immune system help. Bones with more gelatinous material (i.e. the smaller bones) really help with digestive health. Click here for more health information about bone broth.
After looking at over 100 recipes online for bone broth (did you even know there were that many recipes for it?!), I put together the ingredients for my favorites and made a mish-mash of a bone broth recipe. The type of bones you use will determine what spices you include in your recipe. So…for instance, for beef bone broth I used salt, peppercorns, rosemary, etc. For chicken bone broth I would use salt, thyme, rosemary, sage, etc. If you would put it in a soup centered around that particular animal, throw it in!
Bone Broth (Beef)
1.5 – 2 pounds beef shanks (ask your butcher or grocery store person for beef marrow bones)
1 gallon (approximately) water
2 Tbsp apple cider vinegar
2-3 carrots, washed and roughly chopped
2-3 celery stalks, washed and roughly chopped
1 large onion, peeled and roughly chopped
1/2 to 1 bunch Italian parsley, washed
Salt and pepper
3-4 garlic cloves, peeled and roughly chopped
1.–If you want to do this in a slow cooker, alter your measurements to fit the slow cooker (mine fits 1-2 bones, all the veg, and a little more than a half of a gallon of water). In a stock pot, put the bones, the water, and the apple cider vinegar. Set this aside for 20-30 minutes so the vinegar can start to break down the marrow in the bones. If using a slow cooker, do the same thing, but in the slow cooker. Do not put it over heat yet!
2.–Chop your vegetables and add them as you finish chopping. It's okay if they're soaking with the vinegar as well–I just do that part first so I'm not sitting around waiting for 30 minutes after I've finished everything. Put the parsley in the pot…un-chopped…just wash and toss it in!
Isn't that beautiful? Sorry, my slow cooker is black, so it's kind of like vegetables in an abyss.
3.–Add your spices. I put in about 2-3 tsp sea salt, 2-ish tsp peppercorns, 2 tsp rosemary, 2 tsp basil, and 2 tsp thyme. Basically at this point, you should have everything in the pot except for the garlic–that won't go in until the broth is almost finished.
4.–Turn on your heat. On the stove, bring it to a simmer. In the slow cooker, turn it on low. At this point is where many of the recipes differ. Some say to cook it for a few hours; other say cook it for 48 hours. I cooked mine for 24 hours. Obviously in the slow cooker this seems a little less daunting because you turn it on low and let it go. I'm sure on the stove it would be the same, but I'm a little hesitant to keep the stove on that long in our house (Number one, we live in an apartment on a college campus which means SUPER sensitive smoke detectors. Number two, we have an electric stove that randomly decides that it has been on too long and just shuts off–this is why it's hard for me to make jerky and such). So, cook it for 24-ish hours (toss in the garlic during the last hour of cooking) and then strain all the solids out–this is easier if you let it cook for a few minutes.
5.–At this point you can eat it, refrigerate it, freeze it, whatever. It will keep in the refrigerator for about a week, and much longer in the freezer. Add it to your recipes that call for liquid, drink it like tea, or eat it like soup!


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240 m
960 m
Paris café on Tsvetnoy Boulevard
870 m
400 m
Piano-bar and homemade food restaurant in an old Moscow apartment
1.5 km
Uilliam Lamberti's own restaurant
1 km
370 m
970 m
Support the local farmer!
Provide yourself with high quality rural food
700 m
New café serving American dishes by Isaac Correa, the founder of Correas
Restaurant of Tina Kandelaki and Ginza Project
Modern. Stylish. Refined.
Restaurant near Patriarshiye Ponds with Russian cuisine and Soviet quotations
Traditional Russian cuisine and modern temptations
Project by Restaurant Syndicate
Restaurant in a lux-class five-star Lotte Hotel Moscow

subset: commoncrawl


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A Review of Imaging Techniques for Plant Phenotyping
School of Mechanical Engineering, Shanghai Jiaotong University, Shanghai 200240, China
Center for Precision & Automated Agricultural Systems, Washington State University, 24106 N. Bunn Rd., Prosser, WA 99350, USA
School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China
Author to whom correspondence should be addressed.
Sensors 2014, 14(11), 20078-20111; https://doi.org/10.3390/s141120078
Received: 8 August 2014 / Revised: 9 October 2014 / Accepted: 10 October 2014 / Published: 24 October 2014
(This article belongs to the Collection Sensors in Agriculture and Forestry)
Given the rapid development of plant genomic technologies, a lack of access to plant phenotyping capabilities limits our ability to dissect the genetics of quantitative traits. Effective, high-throughput phenotyping platforms have recently been developed to solve this problem. In high-throughput phenotyping platforms, a variety of imaging methodologies are being used to collect data for quantitative studies of complex traits related to the growth, yield and adaptation to biotic or abiotic stress (disease, insects, drought and salinity). These imaging techniques include visible imaging (machine vision), imaging spectroscopy (multispectral and hyperspectral remote sensing), thermal infrared imaging, fluorescence imaging, 3D imaging and tomographic imaging (MRT, PET and CT). This paper presents a brief review on these imaging techniques and their applications in plant phenotyping. The features used to apply these imaging techniques to plant phenotyping are described and discussed in this review. View Full-Text
Keywords: phenotyping phenotype; fluorescence imaging; thermal infrared imaging; visible light imaging; imaging spectroscopy; three dimensional imaging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Li, L.; Zhang, Q.; Huang, D. A Review of Imaging Techniques for Plant Phenotyping. Sensors 2014, 14, 20078-20111.
AMA StyleShow more citation formats Show less citations formats
Li L, Zhang Q, Huang D. A Review of Imaging Techniques for Plant Phenotyping. Sensors. 2014; 14(11):20078-20111.Chicago/Turabian Style
Li, Lei; Zhang, Qin; Huang, Danfeng. 2014. "A Review of Imaging Techniques for Plant Phenotyping." Sensors 14, no. 11: 20078-20111.
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BELOW APPRAISED VALUE! The moment you walk through the custom front doors you will appreciate the meticulous care and upgrades throughout this home. Almost everything in this entire home has been upgraded, from the fireplace stone to the built-ins, flooring, baseboards, lighting and fixtures. Top to bottom has been custom designed. As you wind your way into the kitchen you will find all new Wolf appliances, 2 dishwashers, subzero refrigerator a new "True" wine storage center at the bar with a brand new ice maker. All lighting is custom and no detail has been overlooked in the stylish design throughout the home. New within 2 years, entire Lenox 5 stage AC system, HW tanks. New pool heater, new coping around the pool, indoor and outdoor recently painted. Home has already been set up for whole home WIFI and a smart home features with surround sound. The very private master has black out shades. The master bath is truly a spa experience with custom multi shower and jetted tub. True pride in ownership in every detail of this exquisite home that sits at the end of the cul de sac in this very exclusive neighborhood of West Bay.
Below Ground, Heated Electric, Heated Gas, Custom Upgrades
Boating, Gated, Golf Course, Tennis
Bike And Jog Path, Basketball, BBQ - Picnic, Beach Access, Beach Club Available, Boat Storage, Clubhouse, Community Boat Ramp, Community Park, Community Pool, Community Spa/Hot tub, Dog Park, Exercise Room, Fishing Pier, Golf Course, Guest Room, Internet Access, Pickleball, Play Area, Private Membership, Putting Green, Restaurant, Tennis Court
Bar, Built-In Cabinets, Cable Prewire, Fireplace, Foyer, French Doors, High Speed Available, Smoke Detectors, Vaulted Ceiling, Walk-In Closet, Wet Bar, Cathedral Ceiling, Coffered Ceiling, Fire Sprinkler, Surround Sound Wired, Tray Ceiling, Window Coverings, Zero/Corner Door Sliders
Central Electric, Gas - Natural
Outdoor Kitchen, Patio, Fruit Trees
The source of this real property information is the copyrighted and proprietary database compilation of the Southwest Florida MLS organizations Copyright 2020 Southwest Florida MLS organizations.. All rights reserved. The accuracy of this information is not warranted or guaranteed. This information should be independently verified if any person intends to engage in a transaction in reliance upon it.
The data relating to real estate for sale on this Website come in part from the Broker Reciprocity Program (BR Program) of M.L.S. of Naples, Inc. Properties listed with brokerage firms other than Equity Realty are marked with the BR Program Icon or the BR House Icon and detailed information about them includes the name of the Listing Brokers. The properties displayed may not be all the properties available through the BR Program.


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Every day, our team has the opportunity to work with amazing professionals across the country. We recently had the opportunity to interview Frank T., an interim Nursing Home Administrator, to ask him what he thinks about interim work.
- How long have you been an Interim Consultant with LeaderStat? My first assignment started on October 3, 2018.
- What did you do before you started Interim work? I have been a long term care executive and administrator for over 25 years, including over 10 years as a multiple community COO, and I was a nursing assistant during college. I am also a current member of the KS House of Representatives, having won a special election and then appointed by Governor Jeff Colyer.
- Why did you decide to try an interim role? Why did you choose LeaderStat? I decided that I wanted to travel and do short-term work, usually emergency or troubleshooting gigs, once my children were older and had more independence. Leaderstat team members and I had been talking off and on for some time, but nothing seemed "just right" for me. They were always professional and fun, and they were my first call when I knew that it was time for me to see more of the great USA.
- So far, what do you really enjoy about being an Interim Consultant? The opportunity to go into an assignment with immediate issues that need quick resolution, which has always been a lot of fun to me and a personal specialty.
- Is there a state where you would love to work? I can't pick just one...I'm thinking bicoastal: Washington and Florida.
- Is the process easy (in regards to travel arrangements, requests, etc.)? It's fantastic. Ian and Miranda set up and take care of absolutely everything. I just show up to a community, roll up my sleeves, and get to it!!
- Do you have a favorite memory/moment as a Consultant? I was only on the job for two weeks when my staff threw me a Boss's Day party, as we watched our census grow from 33/50 to 45/50 (fist time to that level in over a year) during that time period.
- What advice would you give to a new Interim Consultant? Go into an assignment with an open mind. I'm a city boy and was asked if I would go to a TINY town surrounded by prairie - Dodge City, Kansas. I wanted to get my foot in the door of Leaderstat, so I agreed. I LOVE THIS PLACE AND MY TEAM and haven't been this happy at work in at least fifteen years.
- Any additional thoughts? I have been talking with the Leaderstat team off and on for a couple of years before finally taking the leap, and now I hope to be one of their go to / go anywhere guys for years to come.
Frank, we can't thank you enough for being such a wonderful LeaderStat Consultant. Thank you for all that you do!


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Welcome to our new style, modern bed and breakfast set in seaside Aberdaron, only a short stroll down the hill to the sea and into the picturesque village with its restaurants, pubs, shops and a church.
- Self service check in to luxury private en-suite rooms with TV.
- Free Wi-fi and self service tea and coffee.
- Includes all morning self service continental breakfast.
- Ample free parking.
- Convenient for seaside, golfing, touring or walking holidays.
- Residents lounge with TV.
- Garden with patio and seating.
- Boot storage and drying area.


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Bob Dylan – Tempest
Bob Dylan, or the name his mother gave him, Robert Zimmerman, released his 35th studio album this year. I've listened to it intermittently but only when I have exhausted Beiber and Rebecca Black. I wander if she and Conrad Black are related, being an awful person is genetic right? I hope this is not the only write up that mentions Rebecca Black and Bob Dylan in the same paragraph. The album is… wonderful. Having only listened to a couple of his early albums I have about 32 in between that prevent me from making any kind of informed decision of its comparative brilliance. Never the less I enjoyed it. It is totally different from the mind bending puzzle of songs like Its Alright Ma (Im Only Bleeding) 1965. The title of the album ,Tempest, seems to be a suggestive nod to Shakespeare and in the same motion a wave good bye to making records. But I believe this has been contested by Dylan himself (although I am probably wrong about this). Tempest is never as sentimental or as nostalgic as songs like Girl From The North Country 1963 or Shelter from the Storm 1975. But it still has allot to offer. It has Catchy blues riffs and an old folky sound. Some songs can get a bit repetitive and none have the spunk that filled the balls of Like a Rolling Stone 1965. Buy it though, its good.
>A second, perhaps more well informed opinion.<


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Claire Beatty
Editorial Director, Asia MIT Technology Review Insights
Editorial Director, Asia MIT Technology Review Insights
Claire Beatty is editorial director for international markets at MIT Technology Review Insights. She partners with clients across emerging regions to develop thought leadership that drives conversations around the way that technology is shaping our lives.
Claire has lived and worked in Singapore since 2007 and has more than 15 years of experience in consulting, editorial, and communications roles. She began her career in London as a researcher in the Technology Practice at CEB (now Gartner), developing best practice case studies from world-class IT organizations. On moving to Singapore she joined the Economist Intelligence Unit as senior editor for Southeast Asia, creating client-commissioned content on issues such as trade, innovation, and the outlook for different sectors in the region.
From 2012 to 2015 she took a consulting role with boutique leadership firm BTS, where she led worked with business leaders around the region on strategy alignment, innovation and workforce mobilization. A highly experienced chair, facilitator, and program designer, Claire has led dozens of workshops and events across the region for companies including Prudential, DBS, Unilever, Deloitte, and HP.
Before joining MIT, Claire was group communications director for logistics firm JF Hillebrand. She holds a bachelor's degree in European Studies from the University of Leeds and a Postgraduate Diploma in Law.


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You Can Have Whatever You Want (detail), 2019, oxidized copper, oxidized brass, silver, cast bronze remnant of longing, 305 x 15 x 5 cm, 3.75 kilos, photographer: Sigrid Kuusk, model: Taavi Teevet
EKA galerii (Põhja pst 7)
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EKA galerii (Põhja pst 7)
Start Date:
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Erinn M. Cox artist talk at her solo show "loneliness is the slowest death : a requiem for longing"
Join the artist for a conversation about the works from her new series titled Longing, including a personal tour of the exhibition at EKA Gallery. The artist talk is in English.
For more about the artist, visit www.erinnmcox.com
The exhibition is open until April 27.
Supported by Põhjala Brewery.


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One Little Word Roundup, 2020
We're pleased to share our OLW choices for 2020 and invite you to do the same!
We're pleased to share our OLW choices for 2020 and invite you to do the same!
Welcome to a Roundup of our OLW posts for 2019!
"Each scene has its own music, and the music is created for the scene. Woven into it in ways we do not understand no matter how we may love the melody of a bygone day or imagine the song of a future one; we must dance to the music of today. If not we will be stumbling around in something that doesn't fit the moment."
I am not sure where to begin, but I do know I can always do better with my hive!
This week my coauthors and I participating in our little New Year's tradition of choosing our One Little Words (OLW's) for 2017.
Checking in on my 2016 One Little Word…
Have you checked in on your OLW?
All week the TWT team has been sharing our One Little Word for 2016! If you missed any be sure to take a look at the inspirational words for the new year.
In the past, I have had to go hunting for my One Little Word, but this year I just knew what it would be.
Expressing thanks for the big things, and seemingly insignificant things, can lead to happiness.
My fourth grade self's advice, my grandmother's influence, participating in the Literacy Leaders' Forum, and even a Facebook quiz and a fortune cookie have all pointed me in the direction of my One Little Word for 2016…HAPPY.
Play is at the top of my list for 2016, and I want to shout it from the rooftops. Pitting play against literacy is a false dichotomy. It's not either/or. The way to teach literacy is to provide time for kids to play, talk, dance and sing their little hearts out!
I finally found my word. I had been looking everywhere, but my word escaped me. I was starting to panic. Was I going to begin 2016 wordless? I thought about all the ways I… Continue reading
When I reflect on the flux in my life, I waiver between pure joy of what's to come and loss of what has been. Moving forward is scary when you have so dearly loved all that has been. Just writing this makes me pause.
When I was twelve, my father came home from a long business trip abroad with a magical gift just for me: a Polaroid camera with half a dozen boxes of film. This was,… Continue reading
I thought a lot about my word for 2015. Anyone who is choosing a word to define their year typically does put some weight on the idea. It can mean as much as… Continue reading
Sometimes I'm tempted to say, "I can't…" or "I haven't…" This year, I'm going to add one little word to those statements to keep myself on-track with a very important long-term goal I have.
This morning, as usual, we were running a little behind schedule. "Lily, put on your coat," I said to my daughter, who is five, as I zipped up my son, Jackson's, snowsuit. Lily… Continue reading
I want to concentrate on living a full life, not a busy one.
This year, I vow to make each of my daily 1,440 minutes count. Here is the One Little Word I'll live by this year.


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Leigh-Anne Pinnock from the British girl band Little Mix had a birthday. Her colleagues celebrated it in style and Perrie Edwards wowed in leather and heels.
All members of Little Mix looked great. Leigh-Anne even showcased a few outfits. But for us, the best outfit was Perrie's.
She rocked and incredible long leather dress by Moschino. The dress first made its appearance over the summer with Mandy Moore. She showcased it in a special feature for United Airline's magazine and immediately caught our eyes.
It was a matter of time until other celebrities also try the dress. And we are more than happy that it has finally happened.
Perrie Edwards looks absolutely stunning in the dress. It's definitely a very daring dress and probably not to everyone's tastes. But it can also look superbly elegant. Perrie managed it with ease and looked incredible.
She also rocked a pair of spikey heels with thick ankle-straps. They gave a nice balance to the revealing dress. A studded clutch bag completed the look.
Perrie rocked her hair straight and loose. She opted for matching daring makeup with eyeliner and red lipstick, adding more punch to her look.
Definitely one stunning outfit.


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Would you like to spend a vacation exploring the wonders of ice and snow!? Then, our 11 Day Alaska Natural Beauty is your best choice!
Explore Fairbanks, Denali, Kennicott, Valdez, and Anchorage. Save $1080 per couple from our regular rate for booking by or before Monday March 13, 17
For more info: http://www.righttravel.info/11-day-alaska-natural-beauty-1860.html


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Where to Buy
Interested in carrying Otter® pet products via your online store or brick & mortar location? Please contact our business development department via our Contact Us form.
In addition to our website, Otter® pet products can be purchased at the following locations:
Style A Dog VI: 8168 Crown Bay Marina, Suite 504, St. Thomas US Virgin Islands 00802
The Paw Street Barkery: 477 Britton Street, Chicopee Massachusetts 01020


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Boost your standardised test score and increase your chances of getting into your dream university.
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Connect with high achieving tutors who will teach you how to trackle the GRE and help you gain admissions into a renowned graduate school program.


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Global Directory Of Fine Food Hospitality Leisure and Tourism
Search For Premium Suppliers Manufacturers and Service Providers
FREE to Use - No Commissions Taken
Chefs Biography - Chef Rachel Allen
Often referred to the Irish Cooking Queen, Rachel was raised in Dublin and studied at the world famous Ballymalone Cookery School. With a reputation for practical simple and delicious recipes, Rachel's cooking style is ideal for family and friends. She is author of numerous bestselling cookbooks, an international broadcaster, and contributor to many Irish publications.
Profile Description
Your Gateway To The
World Of Travel and Leisure
Copyright © 2016 leisurechain.com
Your Gateway To The
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Copyright © 2016 worldfreightdirect.com


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Scottish Immunisation Programme - Shingles Vaccination
Scottish Immunisation Programme - Shingles Vaccination
Details of the 2019-20 Shingles (Herpes Zoster) Vaccination Programme
The CMO letter in respect of the 2019/20 Shingles vaccination programme has been published. For the September 2019 – August 2020 programme all people aged 70-79 years on 1st September 2019 not previously vaccinated with shingles vaccine are eligible.
In order to further support the Shingles immunisation programme. NHS Education for Scotland in partnership with Health Protection Scotland has revised it'sresources for registered healthcare practitioners. These can be found below and include training slides and accompanying notes.
Please note: These educational resources continue to be updated as required to support this programme but do not replace the clinical judgement of practitioners. Practitioners should refer to the Public Health England Green Book Chapter when administering the vaccine.
Slides (Office365 PowerPoint) - (open as read only) - last reviewed August 2019
Slides with notes pages(pdf) - last reviewed August 2019
Screening tool for contraindications for shingles vaccine
Shingles vaccine is a live attenuated vaccine and is therefore contraindicated for some patients groups.
A screening tool for contraindications for shingles vaccine has been produced by Health Protection Scotland and is available at
This tool may be used to aid identification of patients who are contra-indicated for this vaccine and includes explanatory notes for registered healthcare practitioners.
The questions in the screening tool are designed for completion either by the patient or by the registered healthcare practitioner in a structured interview with the patient.
Please note: The screening tool is designed to help identify patients who may be contra-indicated for shingles vaccine and does not replace the clinical judgement of registered healthcare practitioners.
Full details are provided in Green Book Chapter on shingles (herpes zoster)


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Use the drop down "Select Specialty" option below to click on the type of work or service you're looking for.
Or use the Search box or alphabet option to find a specific company.
Zamora Sod FarmZamora Sod Farm Contact: Trebor Stewart
Speciality: Landscape Materials &/or Irrigation Supplies - Supply Only, Nurseries
Refer for Residential Work: TRUE


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Use our Smart Manufacturing comic book and app to showcase how augmented reality, IoT, and additive manufacturing are transforming modern manufacturing.
Inspire young people by demonstrating that manufacturing in a smart connected world is filled with technology, advanced skills, and creativity.
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Oldest Dog Sign in Abingdon
September 11, 2018
In 1956 a clause was added to the British Road Traffic Bill so that owners of dogs allowed on a 'designated road' without a lead would be liable to a fine of up to £5. This sign, near the entrance of Sydenhams, shows that Ock Street in Abingdon was such a 'designated road'. It must be the oldest dog sign in Abingdon and dates from before the Borough ceased to exist in 1974. Unless you know better.
Filed under: heritage
6 Comments Leave a Comment
1. Geoff Bailey | September 12, 2018 at 7:24 am
Wonder why the painter painted the B and the A in blue.
2. Janet | September 12, 2018 at 8:27 am
I can remember Abingdon before the Council had a dog warden. People used to throw their dogs our to roam. There were three aggressive alsations terrorising people outside Reynolds Way shop. The police were called. They came and looked at the dogs and then drove off. The council had to put another exit into our back road as a neighbour was attacked by anothers bull dog when she went to the shops on her bike. Since the dog warden we do not get any of this, although there is a problem with dog owners throwing dog poo bags in hedges and trees. It would be better to have left the poo on the ground to degrade.
3. rudi | September 12, 2018 at 5:03 pm
i can remember as a kid walking through hogarth place and being followed the entire length of the road by about 6 barking dogs – pretty terrifying for a kid.
they never actually tried to bite me but even so….
one did try (as i decribed to my parents when i got home much to their shock) dancing with me as she stood on her hind legs (!) one time.
4. Daniel | September 12, 2018 at 9:42 pm
Didn't dog poo used to turn white?
5. R. | September 13, 2018 at 7:59 pm
I wish it did degrade when left un-scooped instead of getting on shoes, trodden into houses, let alone being a danger to health, particularly for children.
6. Colin Bartlett | September 21, 2018 at 1:47 pm
Suspect stick on letters. The adhesive failed revealing the true blue colour of the paint/enamel underneath.
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Herb Fish
Combining different types of herbs not only gives this speedy fish depth of flavor, but it also results in a beautiful dish. Yvonne Nemec of Phillipsburg, New Jersey relates, "this is such an easy dish and so delicious. The herbs compliment the delicate flavor of the fish. We love it!
Total TimePrep/Total Time: 20 min.
Makes4 servings
- 1/4 cup finely chopped onion
- 2 tablespoons butter
- 1/2 teaspoon minced garlic
- 1 tablespoon lemon juice
- 2 teaspoons dried parsley flakes
- 1/4 to 1/2 teaspoon salt
- 1/4 teaspoon dried tarragon
- 1/8 teaspoon dried thyme
- 1 pound whitefish or sole fillets
- 1/4 cup dry bread crumbs
- In a small microwave-safe dish, combine the onion, butter and garlic. Microwave, uncovered, on high for 1-2 minutes or until onion is partially cooked. Stir in the lemon juice, parsley, salt, tarragon and thyme.
- Arrange fillets in a greased 2-qt. round microwave-safe dish. Top with half of the butter mixture. Stir bread crumbs into the remaining butter mixture; sprinkle over fillets.
- Cover and microwave on high for 4-6 minutes or until fish flakes easily with a fork.
Editor's NoteThis recipe was tested in a 1,100-watt microwave.
Nutrition Facts4 ounce-weight: 186 calories, 7g fat (4g saturated fat), 69mg cholesterol, 330mg sodium, 6g carbohydrate (1g sugars, 1g fiber), 23g protein.
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Feb 15, 2015
Can all of this be baked and/or fried or broiled? If so, what steps must b e taken?
Nov 20, 2011
The thought of microwaved fish does not appeal to me, so I sauted the fish on the stove. I otherwise followed the recipe using talapia fillets. This is a very easy dish that is flavorful and has good texture. It also looks great; company would be impressed. I will surely make this again.


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Top Printing, Branding & Web Solutions Company In Nigeria
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Our Podcast Interview with 23-Year St. Louis Public Radio Veteran Bill Raack
"You try to be prepared as best you can—but you never are," says news veteran Bill Raack in response to the question of how to cover challenging stories, like the death of Michael Brown in Ferguson in 2014, the not-guilty verdict of police officer Jason Stockley and the untimely death of Missouri Governor Mel Carnahan, all of which happened during his tenure as news director and news editor at St. Louis Public Radio. No one needed to tell him not only how difficult it would be to break into the field of journalism, or how taxing the actual work would be once he got there.
Raack, a St. Louis native, began at St. Louis Public Radio in 1995 as a morning-news host. Three years later, he was promoted to news director, where he remained for nearly 20 years. Taking cues from National Public Radio, under Raack's leadership the organization nimbly rode the massive wave of media transition into digital content, delving into the world of podcasts, social-media communication and quick-hitting stories.
Raack now works in media consulting and training for the St. Louis-based PR firm The Vandiver Group and will be a teaching a class about how to create a successful podcast or audio news story this fall at University College at Washington University in St. Louis. The fall-semester course will take place on Tuesday nights from 6 to 8:30 p.m. beginning Aug. 27, and students will have the advantage of Raack's wealth of experience.
Raack recorded a podcast with us in which he discusses his career and life in public radio, how to cover difficult stories, what it takes to be a contemporary reporter and much more. In Raack's upcoming class, students will have the opportunity to learn from, as you'll hear, a true master of the medium.
Register for "Audio Storytelling: From Podcasts to Newscasts"
Cover image courtesy of Jonathan Velasquez.
This post has been brought to you in part by the mentioned organization. Thank you for supporting the companies that keep ALIVE growing.


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Scrumptious Chef Turns 8
Our website just marked 8 years of operation. In that span we've published 3,412 articles. An average of 426.5 posts per year.
We went from being the best, most active food blog in Austin, Texas to being the best, most active food-based website in New Orleans, Louisiana.
Time to throw a rack of ribs on the smoker and crack open a bottle of Heaven Hill Bottled In Bond.


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Personal statement for Ph.D. candidacy
- Sometimes the dreams of first-grade naivety are the only dreams ever realized.
- But more importantly, Murray Schwartz writes with less-confident letters in a small notebook on his desk
- Of course, to arrive at such a world, I need to start walking.
- It is a stretch, yes, but I believe at the core of art is a distortion of life necessary for creativity, the exploitation of a single example into a rampant archetype
Sometimes the dreams of first-grade naivety are the only dreams ever realized.
In all probability, I will never read every book ever written. To think of the amount of novels, manuals and reference materials in the Emerson College library is staggering, not to mention the Boston Public Library, the Library of Congress, the lost world of Alexandria. Impossible, maybe, but as Freud said, dreams are only wish fulfillments, and all I wish is to learn, from books and the people who write them and, most importantly, from the people who read them. I wish to learn from teaching.
[...] There are too many books in the world to read, but I trust him to help me learn what I can in whatever time I have. But more importantly, Murray Schwartz writes with less-confident letters in a small notebook on his desk. He writes what we teach him, like a student. We make our own connections, our own outside allusions; we drop our own authors and titles and quote our own lines and passages. And I realize, at my seat by the window, that there is still so much he does not know, an entire other Barnes and Noble across the city within which he has yet to even stand in line. [...]
[...] Searching for some semblance to a proposed area of study, and really the only thing that grabs at my mind and settles in my heart is the nagging fact that I am very, very gay, and very, very angry about it. Let me clarify. My anger is not really centered on my own homosexuality, but instead on my homosexuality as seen by the eyes of a general population not really acquainted with the actualities of being a lesbian. Instead they assume all kinds of things about me, little things and big things, sexual things and personal things and things about my parents and things about the children I might not even have and things about what I may or may not have learned in school/church/back alleys. [...]


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EMA 2018 has been won by Lea Sirk with the song 'Hvala, Ne!'. She will now represent Slovenia at the Eurovision Song Contest 2018 in Lisbon later this year.
Big names like ManuElla and Tanja Ribic were already eliminated in the semi final, as eight acts remained for the final on Saturday. Including the runner-up of EMA 2017, boy band duo BQL.
Lea Sirk won the jury however was only third in the televote with her energetic entry "Hvala, Ne!". Boyband BQL won the national televote for the second year in a row, but once again saw their Eurovision hopes crushed by the jury.
Check out Lea Sirk's Eurovision song for Slovenia:
Results of EMA 2018 in Slovenia:
- Lea Sirk – Hvala, Ne! (1st: 116 points)
- BQL – Promise (2nd: 106 points)
- Indigo – Vesna
- Ina Shai – Glow
- Marina Martensson – Blizu
- Lara Kadis – Zdaj sem tu
- Proper – Ukraden cvet
- Nuška Drašček – Ne zapusti me zdaj


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This blog follows my art journey, which started long ago but picked back up in December 2017. I post my own original art as well as my thoughts about art-related topics. I love interacting with my readers and I hope you will consider following along! I welcome your questions and comments.
-Anna C. Pishko


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My name is John Staats and welcome to my website
I was born and raised in Akron, Ohio, and pursued a career early in visual arts with an honors art scholarship to Kent State where I earned an B.F.A. with a major in graphic design. I moved to New York City on finals week (after my last final) having secured a job in a small (but swanky) design firm. After a decade I was a department director in a big-time Madison Avenue advertising agency. I specialized in fashion editorials, and both financial and pharmaceutical ad campaigns. After my roommate discovered a 3D level editor for the world's first 3D game called called Quake, I purchased my first PC the very next day (I was exclusively a Macintosh user) and began my new hobby–3D level design. I couldn't believe I could actually build and "walk around in" some of the old Dungeons & Dragons adventures I authored when I was in school.
Four years and about ten thousand hours of level design later, I had a portfolio worthy enough to earn me a place in the computer games industry. I moved to California to work for Blizzard Entertainment's secret new project, called World of Warcraft (see my book for details). After a decade on WoW, I spent a year on a doomed project, called Titan, whereupon Blizzard gave me the heave-ho. I'd outlived my uselessness.
A few years later I developed an undiagnosed medical condition in my hands that prevented me from sustained computer use. I have been unable to make or play computer games since. In tandem with traditional mouse-keyboard inputs, I use voice activation for the bulk of my writing (I'm still waiting for the time when talking to my computer doesn't feel silly). With California and the computer games industry in my rear-view mirror, I'm moving on to personal projects. After publishing The WoW Diary, I'm going to develop a new type of dungeon-crawl board game; one that I would also like to crowd-fund on Kickstarter. If you enjoy board games and want to know when it's ready (you saw what I did there!) add your email in my spam-free mailing list. I expect to send emails once a year at most, only for previews and early-releases.
My company is called whenitsready, and yes, I know there's supposed to be an apostrophe, but sometimes we graphic designers take our liberties. whenitsready is a one-man operation. The goal of my company is to publish the best books and board games possible, iterating and polishing until they can be improved no further: I picked up this little formula from a certain computer game company we all know. To contact me, use my form below.


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Website: http://www.crystalbridalaccessories.co.uk
The Jules Touch offers a wide range of Bridal Tiaras & Accessories for the Bride, Bridesmaids & Flower Girls. We can adapt our handmade ranges to suit your own colourscheme. We offer a prompt, reliable and professional service to help make your day special.
Tel: 0113 3492009
Website: http://www.the-jules-touch.com/
Debbie Graham Jewellery is an online wedding store with a large collection of wedding jewellery and bridal jewellery accessories for all budgets and tastes. Our beautiful wedding jewellery collection features a great range of wedding necklaces, back drop necklaces, wedding bracelets, wedding earrings, bespoke bridal hair accessories, bridal bracelets, bridesmaids jewellery, hand made wedding jewellery. Each piece of jewellery is handmade to order, which means that the colours of stones & beads used can be altered to match your wedding theme Type of Wedding Website = Bridal Wear
Tel: 01937 580607
Website: http://www.debbiegrahamjewellery.com
Dream of Silver - Sterling Silver Jewellery
Exclusive handmade sterling silver jewellery made from the finest quality materials. We also offer a range of silver jewellery for children, ideal for bridesmaids and flower girls.
Tel: 07880 720852
Website: http://www.dreamofsilver.com/


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SIMI VALLEY, Calif. — Ronald Reagan turned 93 in seclusion Friday in his Los Angeles-area home while schoolchildren serenaded his wife, Nancy, at his presidential library and she dedicated the cornerstone for a new pavilion to house the former Air Force One.
Gov. Arnold Schwarzenegger proclaimed it Ronald Reagan Day in California, and there were celebrations in Illinois, where he was born and went to college.
"Ronald Reagan's vision of 'peace through strength' impelled the decisive end to the Cold War, and his commitment to our armed forces contributed to the restoration of patriotism and pride in America," Schwarzenegger's proclamation read.
Bathed in sun at the hilltop Ronald Reagan Presidential Library, 126 youngsters sang "Happy Birthday" to Mrs. Reagan. The construction crew building the pavilion presented her a birthday gift for the Gipper — a metal lunch pail. She laughed when she found out it was filled with jelly beans but did not speak at the brief gathering.
The former Air Force One, already on site with its wings clipped and stored alongside the gleaming fuselage, will be displayed when the pavilion opens in spring 2005. The jet was used as Air Force One by Richard Nixon, Gerald Ford, Jimmy Carter, Reagan, Bill Clinton and both Bushes before it was retired from service in 2001, according to Boeing Co.
While the ceremony was taking place, Reagan, who has lived longer than any other U.S. president, was at home 50 miles away. He's remained in seclusion since disclosing nearly a decade ago that he has the memory-sapping Alzheimer's disease.
Since then, little information has been released about him. Asked Friday how her husband was doing, Nancy Reagan simply nodded and said "fine." She has said she's not sure her husband even recognizes her.
"It's been difficult for Mrs. Reagan," said close friend Merv Griffin. "She's amazing. That's probably the loneliest life of all."
Michael Reagan told CBS' "The Early Show" that he saw his father the other day.
"I have to be honest with you, he had great color. ... You can't communicate with him, but he has a strong heart and strong lungs. All you can do is just hug him, and give him a kiss and say a prayer and hope for the best," he said.
Reagan was born Feb. 6, 1911, in Tampico, Ill.
At Reagan's birthplace, a second-floor apartment, about a dozen sheet and layer cakes were prepared for visitors. In Dixon, Ill., where the family moved when Reagan was in fifth grade, tours of Reagan's boyhood home were scheduled for about 100 fifth-graders.
In Eureka, Ill., Eureka College paid tribute to its most famous graduate Friday by reopening a campus museum that has been closed because of an arson fire. The museum houses about 3,000 items donated by Reagan, a 1932 graduate.
© 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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6 April 2018. Rome. The SCAR Strategic Working Groups ARCH, AKIS and Food Systems organised jointly the Workshop: Programming Research and Innovation for Improved Impact
The workshop consisted of Key Note Speakers showing how to ex ante programme research and innovation for improved impact, at the international, national and regional scales. This was followed by Panel Discussions with experts drawn from the EC, IFAD, FAO, OECD, CREA and open discussions with participants.
The aim of the workshop was to provide, to funders and researchers, concrete recommendations on how to strengthen programming of research and innovation to reach tangible impacts
- Lessons learned during the workshop will be used as the basis of a Policy Brief with specific recommendations and guidelines on how to better programme research and innovation activities to achieve improved impact.
- Participants were funders, policy makers and researchers from international organisations, European Commission Directorate Generals, SCAR Members, National Research and Innovation institutions and sub-national managing authorities.
- Welcome – by Roberto Henke, Director Policy and Bioeconomy, CREA, Italy
- Setting the scene – Trends in programming Research and Innovation for Impact – by Ben Davis, FAO
- What does it take to boost the culture of impact in our research institutions? – by Etienne Hainzelin (Coordinator of the Impress project)
- Programming Research and Innovation in an Integrated AKIS: The Irish
- Experience – by Kevin Heanue (Evaluation Officer at Teagasc, IE)
- representing an AKIS point of view
- Reviewing S3 in Tuscany: experiences from regional integrated projects – by Emanuele Fabbri (Region Tuscany) & Professor Marco Vieri (Univ. of
- Florence)
- The perspective of funders and policy makers
- The perspective of researchers and research institutes
- Presentation of main conclusions – by Stefano Bisoffi, Former Technical Director CREA
The ImpresS ex post method: a co construction process with partners
The ImpresS ex post method was developed within a strategic project at CIRAD, called "Innovation-Impact", which aimed at constructing an impact assessment framework that would be adapted to the partnership modus operandi of CIRAD, and to develop a "culture of impact" in the institution.
This method was built from different sources:
- Impact evaluation literature;
- Transdisciplinary collaboration with international organizations: notably experts (CGIAR, WUR, FIBL-IMPRESA) with a particular fruitful partnership with Asirpa project Team (INRA-ASIRPA);
- CIRAD's own work carried out since 2011 by impact assessment working groups;
- Two methodological workshops organized by CIRAD in October 2014 where CIRAD researchers and their partners from developing countries tested the methodology, and February 2015 when the results were analyzed and discussed, also with partners from other research institutions ;
- Lessons learned and feedback from researchers and their partners from the 13 case studies on which the method was applied between 2015 and 2016.
Source: PAEPARD FEED


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Posted: October 16, 2017
As the mornings turn darker and the leaves start falling from the trees, you are probably realizing what we all do at this time of the year: We are about to see colder temperatures. For those of you who are environmentally friendly or just looking to save a few bucks, you might consider heeding our thermostat tips to conserve energy when the winter chill arrives.
With a little modification, you can achieve comfort and savings with our energy-firendly winter thermostat tips.
The recommended thermostat control setting from Energy.gov is 68 degrees Fahrenheit. If this seems colder than you like it, try out these tips to increase your comfort.
A few small tweaks here and there can quickly add up those energy savings.
Programmable thermostats are an easy way to rake in the savings. Setting a schedule lets you benefit from the energy savings without needing to make daily adjustments to your thermostat controls. Here are some tips for setting energy-saving temps this winter:
If you want to avoid the hassle of having to program your thermostat in response to your habits, consider a smart thermostat. Products such as the Nest and ecobee thermostats modify settings based on learned behavior patterns and can be controlled from a smartphone.
In addition to setting your thermostat appropriately, there are a few extra measures you can take to help your home heat more efficiently, save energy, and pocket a few extra bucks. Try these tips:
Stave off the winter blues and go for green instead. Check out our tips for summer thermostat settings to get you through the last of this year's heat.


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Choose your room
Property Location You'll be centrally located in Spello with a stay at Hotel La Barberie, convenient to San Giovanni Battista Hospital. This hotel is within the vicinity of St. Nicolo Church and Cathedral of San Feliciano.Rooms Make yourself at home in one of the 15 individually furnished guestrooms, featuring kitchens. Your room comes with a memory foam bed. Rooms have private patios. Complimentary wireless Internet access is available to keep you connected.Dining Satisfy your appetite at the hotel's restaurant, where you can enjoy drinks at a bar, take in a garden view, or dine alfresco (weather permitting). A complimentary cooked-to-order breakfast is included.Business, Other Amenities Featured amenities include complimentary high-speed (wired) Internet access, dry cleaning/laundry services, and multilingual staff. Free self parking is available onsite.


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Jacqui and Patricia have their corner of Northeast Harris County in Texas under control. Their strategic mobilization is ensuring the maximization of Democratic voters.
BREAKING: 5 Kids, 3 adults shot and killed at home in Harris County, TX
Guns don't kill. People do. Right? KHOU is reporting this breaking story. HARRIS COUNTY, Texas – The Harris County Sheriff's Office says a man has surrendered after five kids and three adults were shot dead at a home late Saturday evening. An active shooter was reported around 11 p.m. at 2211 Falling Oaks, not far […]
Harris County Precinct 6 Constable Victor Trevino entered a guilty plea (VIDEO)
Harris County Precinct 6 Constable Victor Trevino entered a guilty plea for Misapplication of Fiduciary Property.
New Voter Registration Certificates in Harris County Texas Mailboxes
FOR IMMEDIATE RELEASE PRESS RELEASE January 10, 2014 Media Contact: Justin Concepcion Office713-274-8021 Mobile:713-582-4925 – email@example.com New Voter Registration Certificates in Mailboxes (Houston) – "My office has begun mailing voter registration certificates to 1,876,539 registered voters," said Tax Assessor-Collector Mike Sullivan. "The new voter registration certificates, which will be light orange in color, are expected […]


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Demolition Plus is a family owned and operated company. We take immense pride in the company we've built. With over 50 years of hard work behind us, we look forward to a bright and productive future.
Client: Tomlinson and Ministry of Transportation
Another weekend shutdown over Canada's busiest highway. The demolition of 3rd Line overpass in Bainsville, Ontario was carried out over two nights in April 2018. Another project completed on schedule.
Address: 810 Second St. West , Cornwall, ON. K6J 1H6
Telephone: 613 938-9881
Fax: 613 938-7283


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Hall of Fame quarterback Brett Favre is pro-Eli Manning.
With the Giants offense struggling, the debate has been split between the offensive line and Manning in most cases. Some say Manning doesn't have time to work with a leaky line, while others claim Manning's skills are diminishing.
Favre believes Manning is a pocket passer that needs to be given more time than his line has this season.
"He's not going to win with his feet," Favre told the Daily News' Pat Leonard. "Every once in a while he may scramble, but he is who he is. And when you can protect him he's really good. And I think his demeanor and his personality and his physical attributes really haven't changed and so I think it is up to the team and the organization to provide him -- and I know that they've tried their best -- to provide him with adequate protection. You gotta figure out a way to protect the guy."
In the line's defense, they were giving Manning clean looks for most of their matchup against the Saints' pass rush in Sunday's loss. However, consistency is key for this unit, and that hasn't been proven through the first four weeks.
Favre, who has been opposite Manning a few times over his career, knows the veteran is battling for his team as well.
"I think a guy like Eli, and I don't know this for certain, but I think guys that are really, really true competitors and have played a long time...have a tendency when things go...bad(ly)...you try to do too much," Favre explained. "And I consider that a good quality. You try to offset maybe what your team lacks with your ability. And, yes, that gets you in trouble and then more criticism falls upon you.
"And I'm not saying Eli is doing that. I think he's battling his butt off."
Manning has thrown for 1,055 yards with a 74.2 completion percentage, four touchdowns and one interception so far this season. He has been very conservative, not taking many shots down field as he needs to get the ball out quickly.
Favre hopes more protection shows up moving forward because that is when the real Manning comes out.
"I think given good protection I think you see an Eli that we have known to be there at the end," he said. "I think that that's still there. I don't see skills diminishing, I see an offensive line struggling to protect him right now. And if they figure that out I think you'll see that the Eli that we've known for so long will be there again."


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Our struggle for Justice for the Marikana Miners involves not only educating South Africans and people around the world about the tragic events that occurred at Marikana, but also to assist those who have suffered as a result of their loss. As part of this project," Miners Shot Down" is affiliated with the Justice for Marikana Campaign whose activities have included collecting funds to help support those dependant on the slain miners who have had to struggle with the loss of support after the massacre. To date, The Marikana Support Campaign has dispersed R286,008.47 – food for the striking miners and R126,442 to the Widows Fund.
This money has been used to supplement the loss of income suffered by the miners and their families and has helped to provide basic needs such as food and clothing. There is still a great need for support in the area and with your continued help we can ease the losses and hardships of those still suffering from the tragic actions of the 16th of August 2012. If you would like to help or contribute to the Marikana Support Campaign, please contact Zivia Desai at email@example.com. Finally we would like to thank all our outreach sponsors and donors: Ford Foundation Just Films, Bertha Britdoc Connect Fund, Action Aid South Africa, Open Society Foundation for South Africa and the Heinrich Boell Foundation.
If you would like to support the Justice for Marikana Campaign please visit our Take Action page and download our flyer here.


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Quick Links
Name: Elayta
Synonyms: CT1812
Therapy Type: Small Molecule (timeline)
Target Type: Amyloid-Related (timeline)
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Phase 2)
Company: Cognition Therapeutics Inc.
CT1812 is a small-molecule antagonist of the sigma2 receptor, also known as the progesterone receptor membrane component 1. The rationale behind this therapeutic approach is that ligands for the sigma2/PGRMC1 receptor will compete with oligomeric Aβ binding to this receptor and thus interfere with Aβ-induced synaptic toxicity. CT1812 grew out of screening programs at Cognition Therapeutics. Company scientists have reported that compounds in this series not only block binding of a range of different Aβ species to this receptor but also displace it when applied after Aβ has bound (Dec 2014 conference news).
The structure of CT1812 has not been disclosed, but similar compounds in the series have been reported to enter the brain, occupy up to 80 percent of sigma2/PGRMC1 receptors, and restore behavioral deficits in APP transgenic mice (Izzo et al., 2014; Izzo et al., 2014).
From September 2015 to May 2016, Cognition Therapeutics ran a Phase 1 trial in 80 healthy volunteers aged 18 to 75 in Melbourne, Australia; target enrollment was originally listed as 114. Single-ascending-dose administration was followed by multiple ascending doses given once daily for two weeks. The dose range in this trial spanned 10 to 650 mg; if this would not generate data to set a maximum tolerated dose, doses up to 1,350 mg were to be tried. Outcome measures included safety, tolerability, plasma pharmacokinetics, and CSF CT1812 concentration. At the 2016 and 2017 AAIC conferences, company scientists reported that single doses up to 1,120 mg were given, as were multiple doses of up to 840 mg in young and up to 560 mg in elderly volunteers. The drug was reported to be well-tolerated, with suitable pharmacokinetics, sufficient brain penetrance and target exposure, and minimal drug-drug interactions affecting cytochrome P450 activity (Catalano et al., 2016; Catalano et al., 2017).
From September 2016 to August 2017, Cognition Therapeutics ran a Phase 1/2 trial at four sites in Australia, enrolling 19 participants with mild to moderate Alzheimer's disease supported by a recent MRI. It compared a four-week course of 90, 280, or 560 mg of CT 1812 to placebo, taken once daily, on safety and tolerability parameters. At the subsequent CTAD conference, Elayta was reported to have been generally safe and well tolerated, though there were four cases of lymphocytopenia. Exploratory measures such as ADAS-Cog14, verbal or category fluency tests recorded no difference between groups, but exploratory biomarker analyses yielded possible signals of synapse protection (Dec 2017 conference news).
In April 2018, a Phase 1/2 study started enrolling 21 people whose mild to moderate AD was confirmed by amyloid PET or CSF testing. Conducted at Yale University School of Medicine and dubbed COG0105 or SPARC, this trial will compare a six-month course of 100 or 300 mg of Elayta, or placebo. The primary outcome is cognition as assessed by the Alzheimer's Disease Clinical Study Activities of Daily Living (ADCS-ADL), but the trial will also use the investigational PET tracer UCB-J, which binds to the synaptic vesicle glycoprotein 2A, in an attempt to monitor synapse density before and after treatment (see company press release; Jul 2016 news).
In summer 2018, a Phase 1b target engagement study at the University of Pennsylvania will start enrolling 18 people whose mild to moderate AD is confirmed by amyloid PET. Called COG0104 or SNAP, it will compare single injections of 90, 280, or 560 mg of Elayta or placebo for their ability to displace Aβ oligomers and clear them into the CSF, as measured by a CSF Aβ oligomer assay.
Also in summer 2018, a Phase 2 multi-center study is expected to begin enrolling 24 people with mild to moderate AD as confirmed by amyloid PET for a six-month course of 100 or 300 mg of Elayta, or placebo. As of May 22, 2018, this trial lists CT1812 pharmacodynamic effects on CSF biomarkers, specifically as assessed by CSF neurogranin levels, as primary outcome.
For all trials of this compound, see clinicaltrials.gov.
Clinical Trial Timeline
- Phase 1/2
- Phase 2
- Study completed / Planned end date
- Planned end date unavailable
- Study aborted
|Clinical Trial
|Cognition Therapeutics Inc.
|Cognition Therapeutics Inc.
|Cognition Therapeutics Inc.
Last Updated: 25 May 2018
No Available Comments
Make a Comment
News Citations
- Elusive or Not, Aβ Oligomers Are in BioPharma Crosshairs
- Next Up for Human Brain Imaging: Synaptic Density?
- Meet Sigma2, a New Aβ Receptor?
Paper Citations
- Catalano S, Grundman M, Schneider LS, DeKosky S, Morgan R, Higgin M, Pribyl J, Mozzoni K, Izzo NJ, Safferstein H, Lickliter J. A Two-Part, Double-Blind, Placebo-Controlled, Phase 1 Study of the Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Ct1812 in Healthy Volunteers. Alzheimer's & Dementia, July 2016, Volume 12, Issue 7, Supplement
- Catalano S, Grundman M, Schneider LS, DeKosky S, Morgan R, Guttendorf R, Higgin M, Pribyl J, Mozzoni K, Izzo NJ, Safferstein H. A Phase 1 Safety Trial of the aβ Oligomer Receptor Antagonist CT1812. Alzheimer's & Dementia, July 2017, Volume 13, Issue 7
- Izzo NJ, Staniszewski A, To L, Fa M, Teich AF, Saeed F, Wostein H, Walko T 3rd, Vaswani A, Wardius M, Syed Z, Ravenscroft J, Mozzoni K, Silky C, Rehak C, Yurko R, Finn P, Look G, Rishton G, Safferstein H, Miller M, Johanson C, Stopa E, Windisch M, Hutter-Paier B, Shamloo M, Arancio O, LeVine H 3rd, Catalano SM. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits. PLoS One. 2014;9(11):e111898. Epub 2014 Nov 12 PubMed.
- Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, Mach RH, Craven R, Head E, LeVine H 3rd, Spires-Jones TL, Catalano SM. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. PLoS One. 2014;9(11):e111899. Epub 2014 Nov 12 PubMed.
External Citations
Further Reading
No Available Further Reading


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We had a reader request for a review on the Blinc mascara. Luckily I had it and another similar product, so I decided to give you a mini review on both. I don't have pictures of either on my lashes, so let me know in the comments if you'd like to see a picture comparison of them!
Both of these mascaras are tube mascaras- if you aren't familiar, here's what's up. Rather than conventional mascaras that paint color onto your lashes, these form little water resistant "tubes" around your lashes. They are sweat proof, tear proof, water proof, and rub proof. Your mascara should look as good when you get home from work as when you left in the morning. To remove them, you are supposed to be able to use just water, gentle pressure and a washcloth.
This is the only drugstore dupe of a tube mascara that I know of. It retails at about $10 and claims to do pretty much exactly what the Blinc mascara says. The main difference between the two is the price, and the fact that it comes with a primer. If you're not familiar with mascara primer, it's main purpose is to condition and volumize lashes in advance, before you apply your mascara. It gives mascara a little something to stick to and beefs it up a little bit. I really like this formula- my lashes are not as crispy, and it generally does the same thing. The tubes are still a pain in the butt to get off your lashes, but really that's what you get if you want budge proof mascara during the day- a little extra work at night to get it off. This formula also does very little for your lashes aside from slightly lengthen and darken the lashes.
All in all, I rarely ever use tube mascaras. There is a time and a place for me, and that is when I have allergies and my eyes are puffier than normal. I would rather use my mascaras that really volumize, curl, lengthen and have a WOW factor and these mascaras really don't have those capabilities. However, during allergy season, it's not attractive to have mascara running down your face or flaking all over your cheeks and eye area. Whenever that time of year rolls around, or any time I notice a lot of mascara flaking, I switch to one of these formulas for a while. They are very basic to me and feel kind of boring to me, but it's not impossible to glamorize them if you use an eyelash curler first. If you are the kind of person who uses very basic mascara formulas and just need to lengthen and darker your lashes, you will really like these formulas for every day.
Both are decent formulas, but for how little I use them, I would only ever repurchase the L'Oreal because it's so much cheaper.
Yours in totally tubular mascara,


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|Home Bunch
Bathrooms are perhaps the most utilitarian rooms in the house.
|Julien Nightingale Design
But that doesn't mean they can't also be the most beautiful.
|Style at Home
Talk about inspirational! A tray by the bath full of favorite things is such a little luxury that we could all use for our New Year's relaxation time.
|Thomas Pheasant Design
Speaking of… Of all the elements that combine to make a gorgeous bathroom, the bathtub is by far our favorite!
|New England Home Magazine
Tub or no tub, big bath or tiny, one, simple thing that we can all do to make our baths feel light, luscious and beautifully designed is keep a tiny (or big!) vase full of fresh stems right on the sink.
|Tracery Interiors
*Posts on Design Chic may contain links to sponsor's sites. We try to partner with businesses we think will be of interest to our followers and always strive to bring you content you'll love. Thanks for reading!


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The LEGO Movie Videogame's box art has been revealed by Warner Bros Interactive.
The game's cover art features appearances from characters including Wyldstyle, Vitruvius and Batman, as well as villains such as Lord Business.
Launching alongside next year's film, The LEGO Movie Videogame will be available on Xbox One, PS4, Xbox 360, PS3, Wii U, PC, Nintendo 3DS and PlayStation Vita.
Players will be tasked with collecting LEGO instruction pages in order to build construction sets and virtual buildings across 15 levels.
The game will feature more than 90 characters inspired by the movie, including Emmet, who, having been mistakenly identified as the extraordinary "MasterBuilder", attempts to stop an evil LEGO tyrant from gluing the universe together.
Directed by Phil Lord and Chris Miller (21 Jump Street) alongside Chris McKay, the animated movie features the vocal talents of Will Ferrell, Liam Neeson, Alison Brie and Morgan Freeman.
The LEGO Movie will be released on February 7, 2014 in the US, and February 14, 2014 in the UK.
Watch a trailer for The LEGO Movie below:


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Layla Boots
A goth pair of platform boots with a chunky af sole and a long strap to buckle you up with at the top.
- Platform Height: 5cm
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Customer Reviews
Took about 25 days to come. Many wrote that they are a little small, so I took a larger size, but they turned out to be a little big. (It's ok when I wear thicker socks) I wear them everyday. Very comfortable.There was a slight smell, but quickly disappeared. Satisfied.
Lovely shoes, very light and comfortable. The size was perfect! Pictures are after I wore them for 2 weeks! Awesome quality :)


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Oft-quoted actor Samuel L. Jackson is at it again, and this time it's for a good cause.
The actor, who plays Nick Fury in The Avengers, posted on Reddit:
You can join the conversation here, or donate here.
And read on to see some of the best 300-word monologues posted so far on Reddit.
50 Shades of Grey Anyone?
Mean Girls Monologue
An Excerpt from the Infamous Delta Gamma Sorority Letter


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An independent free newspaper has increased its print run to 24,000 as it marks its fourth anniversary.
Your Local Paper published its first 48-page edition in King's Lynn in March 2013 and now runs to 104 half-Berliner pages.
Owner and managing director Alan Taylor says the title's print-first ethos is paying off, with a digital edition of the paper available only the day after the print edition comes out.
To meet increased demand from readers, YLP last week increased its print run from 23,000 to 24,000, the second increase in a year.
Said Alan: "We are bucking the trend because our readers love the size of the paper which is packed with hyperlocal community news which is well-written and designed.
"The paper is stitched so our readers can handle it with ease and many of our front pages are exclusives with another 60-odd pages of news, leisure and sport.
"Our giveaway is a big thank you to our readers, advertisers and contributors, all of whom have put us where we are today.
"We are the largest and market-leading newspaper in West Norfolk and one of the few titles still to be growing in the UK."
A new editor, Paul Thomas, joined the paper in January and has since redesigned the title with a new focus on community news.
The paper will mark today's anniversary with a goodie bag giveaway, with 400 bags packed with local produce to be given out to readers who visit the office.


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The record industry is notorious for operating under quasi legal auspices.
Cannon and Drama need to do two things. Get Gotti's attorney. If I recall, Gotty had a RICO charge.
Once they get his atty, he/she needs get down the Georgia attorney general and see about putting the record labels on the defensive by requesting an investigation into the labels practices of paying to have songs placed on mixtapes, then PENALIZING the DJ's w/ a raid for selling too many mix tapes. **Cue DMX, DONT BE GREEDY.
The labels are gonna try and eat. They are institutions. Thats what they are built to do, like alligators. However, invading n*ggas houses, thats a declaration of war.
Fools are sitting up here citing the fact that label execs PAY DJ's to put songs on Mixtapes. And? These n*ggas orchestrated payola for hella years too. Whats new?
Jeff Leeds breaks it down in The Times.
The labels' reliance on the D.J.'s is complicated further by the fact that many of the top mixtape creators also double as radio D.J.'s on major rap stations. Many label executives acknowledge that when they write checks to certain D.J.'s to produce a mix CD for an artist, there is often an expectation that the D.J. will play the artist's music on the air — an arrangement that recalls the industry's recent radio corruption scandals involving illicit pay-for-play, or payola.
And many more people now know: last week, local authorities, working with the recording industry's trade association, stunned fans and music executives alike by raiding DJ Drama's studio in Atlanta and arresting him and a fellow D.J., Don Cannon, on racketeering charges. Investigators seized more than 81,000 allegedly pirated CDs and say the pair were producing unlicensed recordings and selling them without permission.
I thought this was a copyright infringement case. Then I came across this @ analoguehole.
The Georgia Supreme Court recently considered and upheld Georgia's own "true names" law, Ga. Code. § 16-8-60(b), against a similar challenge in Briggs v. State,
In both these cases, the court majorities found that the state laws in question were not preempted because the state offense included an "extra element" (lack of an identifying label) beyond the elements of a mere copyright violation. (The "true names" provisions are also drafted so as to apply regardless of the copyright status of the underlying work, or whether the copy was authorized by a copyright owner, so arguably the state true names offenses lack some of the elements of a copyright offense as well.)
However, Georgia's state antipiracy statute goes beyond requiring "true names" labeling, treading into what clearly seems to be copyright territory. The Georgia law makes it a crime to "[t]ransfer ... any sounds or visual images recorded on [any disc, tape, or other] article ... onto any other [disc, tape, or other] article without the consent of the person who owns the master [disc, tape, or other] article from which the sounds or visual images are derived" or to distribute (or possess with intent to distribute) copies of any article to which which sounds or images have been transferred, "knowing it to have been made without the consent of the person who owns the master [disc, tape, or other] article from which the sounds or visual images are derived." Ga. Code Ann., § 16-8-60(a).
Drama's case is a tricky issue b/c there are notions of federal copyright law as well as notions of notions of state racketeering law involved.
MIX TAPES vs. BOOTLEGS: THE DISTINCTION
He goes on to address the distinction between MIX TAPES AND BOOTLEGS and the applicable law and tests.
Unlike a typically street vendor of pirated CDs, a DJ selling mixtapes would want to identify the product as his own, and also will generally (in my admittedly limited experience) identify the various tracks included in the mix. So a "true names" violation is unlikely. Perhaps the Georgia authorities have other RICO predicates in mind that are unrelated to the content of DJ Drama's mixtape CDs (like state tax or licensing violations, or maybe someone has been taking DJ Drama's compilation label, "Gangsta Grillz," too literally). But given the involvement of the RIAA in the raid, and the public statements from the RIAA's Bradley Buckles, et al., it appears that the charges are indeed based on the mixtapes themselves.
If the basis for the DJ Drama RICO charges is indeed a claim of "unauthorized distribution" under Ga. Code 16-8-60(a), then we should expect some vigorous challenges to the statute. It would seem that Simmons and Cannon likely have the means to mount a vigorous defense, and they certainly have the incentive to do so. And given that Georgia's "unauthorized distribution" law so closely mirrors federal copyright law, it also seems quite difficult to see how the Georgia statute could withstand such a vigorous challenge.
Ummmm Sticky legal questions!
I think that is a whole weeks worth of blogging fam.


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Description Edit
This traditional, red-hot meat dish is made and mixed with real herbs, spices, fruit juices, and molasses and grilled to smoky, bold perfection. You can simply pair this with other side dishes as it delivers a tangy, meaty aroma that it enhances.
Ingredients Edit
For the meat and the rubbing base Edit
- 2 tablespoons kosher salt
- 2 tablespoons paprika
- 4 teaspoons granulated garlic
- 4 teaspoons pure chili powder
- 2 teaspoons freshly ground black pepper
- 1 teaspoon ground cumin
- 4 racks baby back ribs, each about 2 pounds
For the sauce Edit
- ¾ cup unsweetened apple juice
- ½ cup ketchup
- 3 tablespoons cider vinegar
- 2 teaspoons soy sauce
- 1 teaspoon Worcestershire sauce
- 1 teaspoon molasses
- ½ teaspoon pure chili powder
- ½ teaspoon granulated garlic
- ¼ teaspoon freshly ground black pepper
For basting/mopping Edit
- 1 cup unsweetened apple juice
- 3 tablespoons cider vinegar
- 2 tablespoons unsalted butter
- 2 tablespoons barbecue sauce
Directions Edit
- In a small bowl, mix the rub ingredients.
- Using a dull knife, slide the tip under the membrane covering the back of each rack of ribs. Lift and loosen the membrane until it breaks, then grab a corner of it with a paper towel and pull it off.
- Season the racks all over, putting more of the rub on the meaty sides than the bone sides. Arrange the racks in a rib rack, with all the racks facing the same direction. Allow the racks to stand at room temperature for about 30 minutes, or until the surface looks moist, before grilling.
- Fill a chimney starter to the rim with charcoal and burn the charcoal until it is lightly covered with ash. Spread the charcoal in a tightly packed, single layer across one-third of the charcoal grate.
- Place a large disposable drip pan on the empty side of the charcoal grate. Fill the pan about halfway with warm water. Let the coals burn down to low heat (250° to 300° F). Leave all the vents open.
- When the fire has burned down to low heat, add two hickory wood chunks to the charcoal. Put the cooking grate in place.
- Place the rib rack over indirect, low heat (over the drip pan) as far from the coals as possible, with the bone sides facing toward the charcoal. Close the lid.
- Close the top vent about halfway. Let the racks cook for 1 hour.
- During that time, maintain the temperature between 250° to 300° F by opening and closing the top vent. Meanwhile, make the sauce and the mop.
- In a small saucepan, mix the barbecue sauce ingredients. Simmer for a few minutes over medium heat, and then remove the saucepan from the heat.
- In another small saucepan, mix the basting/mop ingredients. Simmer for a few minutes over medium heat to melt the butter, and then remove the saucepan from the heat.
- After the first hour of cooking, add 8 to 10 unlit charcoal briquettes and the remaining two wood chunks to the fire. At the same time, lightly baste the racks with some of the mop.
- Leaving the lid off for a few minutes while you baste the ribs will help the new briquettes to light. Close the lid and cook for another hour. During that time, maintain the temperature of the grill between 250° to 300° F by opening and closing the top vent.
- After 2 hours of cooking, add 8 to 10 unlit charcoal briquettes to the fire. Remove the racks from the rib rack, spread them out on clean work area, and baste them thoroughly with some mop.
- Put them back in the rib rack, again all facing the same direction, but this time turned over so that the ends facing down earlier are now facing up. Also, position any racks that appear to be cooking faster than others toward the back of the rib rack, farthest from the charcoal.
- Let the ribs cook for a third hour. During that time, maintain the temperature between 250° to 300°F by opening and closing the top vent.
- After 3 hours of cooking, check if any rack is ready to come off the grill. They are done when the meat has shrunk back from most of the bones by ¼ inch or more.
- When you lift a rack by picking up one end with tongs, bone side up, the rack should bend in the middle and the meat should tear easily. If the meat does not tear easily, continue to cook the racks.
- The total cooking time could be anywhere between 3 to 4 hours. Not all racks will cook in same amount of time. Lightly brush the cooked racks with some sauce and, if desired for crispiness, cook them over direct heat for a few minutes.
- Transfer to a sheet pan and tightly cover with aluminum foil. Let rest for 10 to 15 minutes before serving. Serve warm with the remaining sauce on the side as well as over rice.
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Philipp Plein Leather Jackets
Philipp Plein designer coats and jackets are available online and instore at Boudi UK. Browse our collection of womens outerwear, for all occasions and all seasons throughout the year. Philipp Plein is pure luxury with his latest Ladies Collection embodying the designers rebel streak, and glamourous ideals making thePhilipp Plein brand instantly recognisable.
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To filter the sessions, select one or more options in one or more filters. Click on a filter or start typing to see options. Then click Search.
Location: R1
Instructor: PROTSIK[P]
Style: Blues Canadian Folk Irish Maritime New England Québecois (French Canadian) Swing
Doug, who directs the wonderful Maine Fiddle Camp,plays "old-time piano" for dances, melodramas, honky tonk saloons, and silent movies. Doug will demonstrate, elucidate, and illuminate while answering any and all piano questions. This is primarily a listening session since we don't have pianos for everybody.


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With scenic vistas and event spaces brimming with charm, these premier barn venues set a picture-perfect scene.
New Kids on the Block
"It's a space that's been waiting 130 years to have a party." That's how co-owner Kathy Johnson describes Earl & Wilson, the Victorian-meets-urban venue she and her husband opened in February.
She's right; with its size (it can hold upward of 400 people, 320 seated), windows to let the sun shine in and exposed beams, stone and brick, Earl & Wilson is sure to be a hit with wedding-planning couples.
The space is composed of three rooms that flow into one another, which means lots of options for ceremony and reception set-ups. The Lounge is the smallest, with seating for up to 18, followed by the 1880 Room, which holds 203, and the massive 1900 Room that has space for 400-plus revelers.
Oh, and did we mention that the ceilings boast more than 30 crystal chandeliers throughout, creating a cool juxtaposition between this old-world elegance and the venue's exposed natural materials? Because it's just as picturesque as it sounds.


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I will be experimenting with a couple of hot wing recipes this Super Bowl Weekend. Here's what you do to make better wings.
Brine your wings in a kosher salt, sugar brine 1 cup of salt to 1/2 cup of sugar to every gallon of water or your favorite Beer. Put wings in a cooler or a container and let sit over night. If you are really ambitious you may brine your wings in BEER also!!!
If they are in a cooler be sure and keep them cold with ice over night you don't want them to get over 40 degrees. Rinse and pat dry. Put on racks and let air dry why you prepare your sauce.
Here are a couple of sauces I am going to use this weekend.
Chuoula and worchestershire a little bit of butter – I'm not giving my measurements to give away all of my secrets!!! Melt butter and combine all ingredients toss and grill or bake till they temp at 165. We grill our wings with salt pepper and granulated garlic and then finish them in the oven after we toss them in the sauce.
Orange Chipotle spicy wings – Orange juice concentrate, Chipotle peppers, Lime Juice and Cilantro. I may soak my wings in this before I grill these Marinate for up to 8 hours. Follow directions above.
Mango, Pineapple, Cilantro, Chipotle pepper marinade – I will make a slurry with this and toss after grilled and heated in oven. The sweetness and sugars of the fruit will caramelize and could burn on the grill so be careful!!!
Bar-B-Que wings!! Sweet and tangy. I make my own sauce, but you could add hot pepper jelly to a bbq sauce and melt the jelly or chutney on a sauce pan and add your store bought sauce to a mild simmer and stir till combined and let cool and toss wings when they are about finished on the grill or finish them in the oven. Remember the sugars will burn if not careful.
Be sure to line the grill or pans with foil to help with cleanup. Cheers!!!