text:
In widely separated parts of Mexico, many people ask the same troubling question: Are our loved ones among the 145 dead found in the mass graves near San Fernando, Tamaulipas?
That's been the question tearing at families in San Pedro Pochutla, a town in the southern state of Oaxaca. Last summer, ten townspeople set off on a long journey to the northern border state of Tamaulipas. None of them has been heard from since.
"Yes, they have to be returned safe and sound," insisted Maria Vizarratea Salinas, San Pedro Pochutla resident and sister of three men missing in Tamaulipas.
"We wouldn't wish this situation even on our worst enemy. It is a desperate situation we are experiencing," Vizarratea said.
In comments to the Mexican press, Vizarratea said the last possible clue anyone has of their loved ones' whereabouts comes from a phone call a sister made to her husband who was also part of the travel group. A strange man answered the spouse's cell phone with the greeting "Federal Police." Thinking she had reached a wrong number, the sister dialed again only to get the same man on the line, according to Vizarratea.
Relatives of the disappeared men from Oaxaca rejected the notion that their family members were involved in organized criminal activities, claiming that several of the men went to Matamoros, Tamaulipas, to purchase vehicles. Buying and selling used cars from the US has long been a popular business in Mexican border communities.
San Pedro Pochutla is not alone in its agony over the destinies of people who seemingly dropped off the face of the earth in Tamaulipas. A procession of 400 people recently filed into the saturated Matamoros morgue in search of disappeared family members. Besides locals, the anguished visitors included people from Oaxaca, Guerrero, Veracruz, Hidalgo, Mexico City, Zacatecas, Michoacan, and Jalisco.
Last month, relatives of missing persons staged a march in the Michoacan state capital of Morelia to press authorities for answers in the cases of 40 people reported disappeared in Tamaulipas and other states in 2010 alone.
In Guanajuato, meanwhile, relatives of eight men reported missing in Tamaulipas recently submitted DNA samples to the state attorney general's office, in an effort to find out if their relatives were among the dead recovered from the San Fernando mass graves earlier this month.
Angeles Lopez, director of the Victoria Diez Human Rights Center, said the exposure of the Tamaulipas graves prompted more relatives of missing persons to come forward. Prior to the macabre discovery, 27 families had presented formal complaints of disappearance to Guanajuato state authorities. But after news of the graves broke in the media, the number of official complaints rose to 60, she added.
Lopez said some of the cases were turned over to the United Nations Working Group on Enforced or Involuntary Disappearances, which released a preliminary report after conducting a two-week tour of Mexico in March.
According to the UN work group, more than 3,000 people were possible victims of involuntary disappearance in Mexico during the four-year period from 2006 to 2010, the spiraling years of death and disappearance in the so-called narco war.
The list of the missing far surpasses the number of people forcibly disappeared by government security forces during the dirty war against leftist guerrillas and political opponents from the late 1960s to the early 1980s, when somewhere between 600 to 1,200 people were abducted and never returned alive, according to estimates from former Fox administration investigators and Mexican non-governmental human rights organizations.
Added to these numbers are the hundreds and perhaps thousands of people who likewise vanished amid narco violence in various Mexican states- including Tamaulipas- in the years prior to 2006.
Notably, the San Fernando graves were publicly revealed only days after UN investigators wrapped up their well-publicized tour of Mexico. The remains of most of the presumed homicide victims have been transferred to the Mexico City medical examiner's office for assistance in identification.
As of April 20, Mexican authorities had detained scores of people in connection with the burgeoning scandal, including 16 police officers suspected of aiding members of the Zetas criminal organization in committing and covering up mass murder.
Citing the Mexican navy and federal attorney general's office, national press accounts named the alleged Zetas chief of San Fernando, Ramon Rincones, or "El Coyote," as the ringleader of the murder squads.
Rincones, who has not been apprehended, was likewise blamed for last year's mass slaughter of 72 Central and South American migrants also near San Fernando.
Mexico's National Human Rights Commission has identified 71 municipalities in Tamaulipas and 15 other states as constituting zones of high risk for migrants.
The Washington, DC-based Inter-American Commission on Human Rights (IACHR) urged the Mexican government to identify the latest San Fernando victims and get to the bottom of the murders, as well as adopt all the "necessary measures" to prevent the repetition of such horrors.
Further, the IACHR urged the Calderon administration to prosecute and punish "the perpetrators and masterminds" of the crimes, "whether this is a case involving organized crime or State agents in collusion with organized crime…"
Despite a deluge of media coverage, the precise motives behind the mass killings are still unclear, though fleeting statements of alleged culprits combined with assorted media accounts sketch a pattern of the systematic targeting of both Mexican and foreign migrants and travelers in northern Tamaulipas, an area which has been ripped apart by a bloody conflict between crime syndicates since early 2010.
Though the Tamaulipas highways where many people have gone missing are checkered with government checkpoints, inter-city buses have become targets for mass kidnappings. Lately, the pattern of victims has grown from younger men to include women and girls, some of whom have been reportedly raped.
Months before the most recent kidnappings and mass graves scandal, the Tamaulipas grapevine warned of travel on state highways. "The least safe way to travel is by bus, which should be done by day," cautioned a government social worker.
As if to underscore the ongoing threat, federal police officers in Reynosa, Tamaulipas, this week freed 68 persons, including 12 Central American nationals, who allegedly had been snatched from buses or even in the Reynosa bus terminal itself. Two young men were reported detained in connection with the case.
Some stories contend that migrants and travelers are forced to work for cartels or sold as prostitutes. In one case reported in Reynosa, two women were murdered after escaping from their captors and seeking out help from police and immigration authorities. Instead of arresting the criminals, the police purportedly turned the women back over to their kidnappers, who then killed the unlucky pair and left their bodies to rot as a warning to other captives.
Other accounts suggest mass killings were the fault of a psychotic, out-of-control Zeta dubbed "El Kilo," and/or the bloody culmination of Mexican twists on the doctrines of "preemptive war" and counterinsurgency-inspired "population remova" in which men (and some women) of a certain age were eliminated if they refused to work for the underworld, or were just simply snuffed out before they happened to become hit men or employees of the rival Gulf Cartel.
Viewed in a broader context, Tamaulipas has long been a place bearing the socio-political characteristics of a large and contested feudal estate.
Back in the 1980s and preceding decades, much of the region was controlled by oil worker union chief Joaquin "La Quina" Hernandez Galicia. The so-called "cacique," or regional strongman, was deposed by then-President Carlos Salinas in one of his first, high-profile acts after taking office following a widely-suspected election fraud.
Crime syndicates, especially the Gulf Cartel, then filled the power vacuum.
The period after 1988 would also herald the coming of the North American Free Trade Agreement, legal changes in the system of Mexican land ownership, the farm production crisis, climate disasters, spikes in Mexican and Central American migration to the US, and the arrival of peak oil combined with soaring energy demand. Suddenly, Mexican petroleum exports acquired a much greater value than henceforth was the case, as did the passage of the commodities across the US border.
All these storms and streams of people, trade and illicit products converged on the highways of Tamaulipas and were then funneled on their merry way to the money centers of the US heartland.
Sources: El Universal, April 20, 2011. Article by Alberto Morales. El Sur/Proceso, April 19, 2011. El Diario de Juarez/El Universal, April 18, 2011. Cimacnoticias, April 14, 2011. Article by Patricia Briseno. La Jornada, March 14, 21 and 28, 2011; April 19, 2011. Articles by Victor Ballinas, Francisca Meza, Pedro Miguel, Notimex, and editorial staff.
Proceso/Apro, December 29, 2010; March 23, 2011: April 17, 18, 19, 20, 2011. Articles by Jose Gil Olmos, Hugo Vargas, Gloria Leticia Diaz, Jenaro Villamil, Miguel Cabildo, and editorial staff. Inter-American Commission on Human Rights, April 18, 2011. Press release. Mexican Naval Secretariat, April 17, 2011. Press release.
Frontera NorteSur: on-line, U.S.-Mexico border news Center for Latin American and Border Studies
New Mexico State University Las Cruces, New Mexico
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text:
(visited by Jan Krogh, Vytautas Joncas and Algimantas Jakubauskas)
23-Aug-2001 -- 56°N 23°E is maybe Lithuania's most special confluence, because it is situated only 20.8 km west of the country's fourth biggest city of Šiauliai and just about 3 km east of the town of Kuršėnai. Therefore I contacted the main newspaper in the city, Šiaulių naujienos, and asked if they would be interested to explore the confluence together with me. They were very interested!, and journalist Vytautas Joncas and photographer Algimantas Jakubauskas joined me. The location is in the middle of a field just 280 meters north of the Palanga - Šiauliai highway, road number A11/E272, where it is meeting national road 203, just south of the village of Gergždeliai and southwest of the farmstead of Gaudziai.
We hoped it should be closer to a building, but it was not. Just on the southern side of the highway a WW II cemetery is situated. But the location is very nice, and the Šiauliai area has got one more attraction!
Addition on 29-Oct-2001: Pictures 7, 8 and 9 are from the Šiaulių naujienos newspaper article referenced above. Reproduced with permission.

subset: commoncrawl


text:
Nanotube coating helps shrink mass spectrometers
March 25, 2014
A carbon nanotube-coated paper triangle placed on an ionization source charged by a small battery is held in front of a mass spectrometer. Researchers at Purdue University and the Indian Institute of Technology Madras studied the use of carbon nanotubes to advance ambient ionization techniques. (Purdue University photo/Courtesy of Thalappil Pradeep)
WEST LAFAYETTE, Ind. — Nanotechnology is advancing tools likened to Star Trek's "tricorder" that perform on-the-spot chemical analysis for a range of applications including medical testing, explosives detection and food safety.
Researchers found that when paper used to collect a sample was coated with carbon nanotubes, the voltage required was 1,000 times reduced, the signal was sharpened and the equipment was able to capture far more delicate molecules.
A team of researchers from Purdue University and the Indian Institute of Technology Madras performed the study, which is detailed in a designated "very important paper" by the journal Angewandte Chemie.
"This is a big step in our efforts to create miniature, handheld mass spectrometers for the field," said R. Graham Cooks, Purdue's Henry B. Hass Distinguished Professor of Chemistry. "The dramatic decrease in power required means a reduction in battery size and cost to perform the experiments. The entire system is becoming lighter and cheaper, which brings it that much closer to being viable for easy, widespread use."
Cooks and Thalappil Pradeep, a professor of chemistry at the Indian Institute of Technology Madras, Chennai, led the research.
"Taking science to the people is what is most important," Pradeep said. "Mass spectrometry is a fantastic tool, but it is not yet on every physician's table or in the pocket of agricultural inspectors and security guards. Great techniques have been developed, but we need to hone them into tools that are affordable, can be efficiently manufactured and easily used."
The National Science Foundation-funded study used an analysis technique developed by Cooks and his colleagues called PaperSpray™ ionization. The technique relies on a sample obtained by wiping an object or placing a drop of liquid on paper wet with a solvent to capture residues from the object's surface. A small triangle is then cut from the paper and placed on a special attachment of the mass spectrometer where voltage is applied. The voltage creates an electric field that turns the mixture of solvent and residues into fine droplets containing ionized molecules that pop off and are vacuumed into the mass spectrometer for analysis. The mass spectrometer then identifies the sample's ionized molecules by their mass.
The technique depends on a strong electric field and the nanotubes act like tiny antennas that create a strong electric field from a very small voltage. One volt over a few nanometers creates an electric field equivalent to 10 million volts over a centimeter, Pradeep said.
"The trick was to isolate these tiny, nanoscale antennae and keep them from bundling together because individual nanotubes must project out of the paper," he said. "The carbon nanotubes work well and can be dispersed in water and applied on suitable substrates."
The Nano Mission of the Government of India supported the research at the Indian Institute of Technology Madras and graduate students Rahul Narayanan and Depanjan Sarkar performed the experiments.
In addition to reducing the size of the battery required and energy cost to run the tests, the new technique also simplified the analysis by nearly eliminating background noise, Cooks said.
"Under these conditions, the analysis is nearly noise free and a sharp, clear signal of the sample is delivered," he said. "We don't know why this is – why background molecules that surround us in the air or from within the equipment aren't being ionized and entering into the analysis. It's a puzzling, but pleasant surprise."
The reduced voltage required also makes the method gentler than the standard PaperSpray™ ionization techniques.
"It is a very soft method," Cooks said. "Fragile molecules and complexes are able to hold together here when they otherwise wouldn't. This could lead to other potential applications."
The team plans to investigate the mechanisms behind the reduction in background noise and potential applications of the gentle method, but the most promising aspect of the new technique is its potential to miniaturize the mass spectrometry system, Cooks said.
Cooks is a pioneer in mass spectrometry and has worked for years to take mass spectrometers from the size of a car to that of a shoebox.
Early in his career he developed ambient ionization techniques that allowed testing to be done in the air or directly on a surface in its natural environment, as opposed to conventional mass spectrometry techniques that required chemical separations, manipulations of samples and containment in a vacuum chamber for ionization and analysis. Ambient ionization paved the way for faster, more portable mass spectrometry devices that could be used outside of a laboratory.
Cooks and his collaborator Zheng Ouyang, Purdue associate professor of biomedical engineering and electrical and computer engineering, have created several generations of miniature mass spectrometers. They recently published papers on the latest generation, the "Mini 12," in the journal Analytical Chemistry.
Cooks and his team have fine-tuned the tools for use in molecular imaging for cancer diagnostics and surgery; therapeutic drug monitoring; testing for biomarkers in urine; and the identification of food-borne pathogens, bacteria, pesticides and explosives residues.
Cooks is associated with several Purdue research centers, including Bindley Bioscience Center, the Purdue Center for Cancer Research and the Center for Analytical Instrumentation Development.
Writer: Elizabeth K. Gardner, 317-698-9879, firstname.lastname@example.com
Sources: R. Graham Cooks, 765-494-5263, email@example.com
Thalappil Pradeep, firstname.lastname@example.com
Related websites:
Miniature Mass Spectrometers at Purdue
Molecular Ionization from Carbon Nanotube Paper
Rahul Narayanan, Depanjan Sarkar, R. Graham Cooks and Thalappil Pradeep
Ambient ionization is achieved by spraying from a carbon nanotube (CNT) impregnated paper surface under the influence of small voltages (≥3V). Organic molecules give simple high quality mass spectra without fragmentation in the positive or negative ion modes. Conventional field ionization is ruled out and field emission of microdroplets is indicated. Microscopic examination of the CNT paper confirms the nanoscale features at the modified paper surface are responsible for high electric fields. Raman spectra imply substantial current flows in the nanotubes. Analytical performance is shown with volatile and non-volatile compounds and a variety of matrices.


text:
(visited by Gary Withers and Drew Withers)
20-Aug-2001 -- My son Drew and I headed out in the morning for the three-
hour drive to Days Creek. From Days Creek, we followed the
topographical map for one-hour drive on some roads that
started paved and ended up as two parallel tracks separated
by tall grass. The closest point on the trail was about a
quarter mile from the confluence. We hiked back and forth
on the trail looking for a decent opening in the brush to
make our descent easier, but without success, so we plunged
into the foliage. The slope down to the confluence was
quite steep, with an approximate loss in elevation of 400
feet. We clambered down over rotting logs and burned
stumps from some not-too-ancient fire. Most of the new
trees looked maybe ten years old. The ground was gravelly
so the young pine trees provided good handholds to prevent
a fall into the gully.
Looking across the gulch, it was clear to see that the
opposite hill had been completely logged. From top to
bottom, the cleared hill is over 1000 vertical feet high.
Our climb back to the top was a real workout. We went
directly up, hand over hand using the smaller trees for
assistance. The hike down and back up took almost two
On the drive back home we saw smoke from several of the
currently active wildfires in Oregon. Fortunately, none of
them were near enough to affect our trip.


text:
Council Minutes - September 2011
The 114th Meeting
May 24–25, 2011
- REPORT: Task Force on Minority Aging Research
- REPORT: Council of Councils
- REPORT: Working Group on Program
- INITIAL REPORT: NIA Funding Policies and Scientific Review Branch Council Review
- BRIEFING: NIH Research Workforce Diversity
Attachment A: Roster of the National Advisory Council on Aging
Attachment B: Director's Status Report to Council
The 114th meeting of the National Advisory Council on Aging (NACA) was convened on Tuesday, September 20, 2011, at 3 p.m. in Building 31, Conference Room 10, National Institutes of Health (NIH), Bethesda, Maryland. Dr. Richard J. Hodes, Director, National Institute on Aging (NIA) presided.
In accordance with the provisions of Public Law 92–463, the meeting was closed to the public on Tuesday, September 20, from 3 p.m. to 5 p.m. for the review, discussion, and evaluation of grant applications in accordance with the provisions set forth in Sections 552(b)(c)(4) and 552(b)(c)(6), Title 5, U.S. Code and Section 10(d) of the Public Law 92–463.1 The meeting was open to the public on Wednesday, September 21, from 8 a.m. to 1:20 p.m.
Council Participants:
Dr. Norman Anderson
Dr. Lisa Berkman
Dr. Dale Bredesen
Dr. Robert Califf
Dr. Hugh C. Hendrie
Dr. Andrea LaCroix
Dr. Victor Molinari
Dr. Richard Morimoto
Dr. Lennart Mucke
Dr. Eliseo Perez-Stable
Mr. Daniel P. Perry
Dr. Ronald C. Petersen
Dr. Arlan G. Richardson
Ms. June Simmons
Dr. James P. Smith
Dr. Stephanie Studenski
Dr. Susan L. Swain
Dr. Terrie F. Wetle
Ex Officio Participants:
Dr. James F. Burris, Department of Veterans Affairs
Mr. Robert Hornyak, Administration on Aging
Absent Ex Officio Participants:
Dr. Kenneth G. Pugh, National Naval Medical Center
The Council Roster, which gives titles, affiliations, and terms of appointment, is appended to these minutes as attachment A.
In Addition to NIA Staff, Other Federal Employees Present:
Ms. Cate Bennett, Center for Scientific Review
Dr. Chris Sempos, NIH Office of Dietary Supplements
Dr. Lawrence Tabak, Principal Deputy Director, NIH
Members of the Public Present:
Mr. James Appleby, Gerontological Society of America
Dr. Amy F.T. Arnsten, Yale University School of Medicine
Dr. John Christopher Gallagher, Creighton University Medical Center
Ms. Linda Harootyan, Gerontological Society of America
Mary Jo Hoeksema, Population Association of America
Dr. Lisa Kilpatrick, RTI International
Ms. Pat Kobor, American Psychological Association
Dr. Rose M. Li, Rose Li and Associates, Inc.
Dr. Valter D. Longo, University of Southern California School of Gerontology
Dr. Frances McFarland Horne, Rose Li and Associates, Inc.
Dr. Joseph P. Newhouse, Harvard Medical School Department of Health Care Policy
Dr. Olivia Okereke, Brigham and Women's Hospital and Harvard University
Dr. David Scalzitti, American Physical Therapy Association
Dr. Megan Vijiarungam, American Association of Colleges of Osteopathic Medicine
This portion of the meeting was closed to the public, in accordance with the determination that it concerned matters exempt from mandatory disclosure under Sections 552(b)(c)(4) and 552(b)(c)(6), Title 5, U.S. Code and Section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix).2
A total of 886 applications requesting $1,403,479,374 for all years underwent initial review. The Council recommended 470 awards for a total of $1,025,924,211 for all years. The actual funding of the awards recommended is determined by the availability of funds, percentile ranks, priority scores, and program relevance.
Dr. Hodes welcomed members to the open session of the 114th NACA meeting and called the meeting to order at 8:00 a.m. on Wednesday, September 21, 2011.
Director's Status Report
Dr. Hodes reported that no new or definitive information was available on the budget. There has been some talk about a continuing resolution, at lower levels than FY2010-11, through mid-November 2011. All agencies might be required to propose plans for significant reductions from FY2010-11. At present, however, nothing has been confirmed.
Congress has passed the National Alzheimer's Project Act (Public Law 111–375), which establishes a committee that reports to the U.S. Department of Health and Human Services (HHS) and to Congress on a national plan to address the escalating burden of Alzheimer's disease (AD). Council member Ronald Petersen, Ph.D., M.D., will serve as Committee Chair, and Dr. Hodes will represent NIH. The names of non-Federal members can be viewed online, but the names of Federal members have not been announced yet. Dr. Hodes expects to provide an update at the January 2012 Council meeting.
Dr. Hodes focused the rest of his report on NIA communication and outreach activities, which have become vital in a time of fiscal challenges. Because of increasing Congressional interest and the work of constituents and advocacy groups, NIA has participated in two Congressional hearings in FY2011: one focused on AD in the House Energy and Commerce Subcommittee on Health, and a second focused on international efforts to address AD in the House Foreign Affairs Subcommittee on Africa, Global Health, and Human Rights. NIA also has increased its activity from two Congressional briefings per year in FY2008, FY2009, and FY2010 to seven in FY2011. In addition, NIA has increased its outreach and visits to Congressional districts, with visits to Minnesota, the U.S. Virgin Islands, and New York.
The visit to Minnesota is an excellent prototype of the NIA outreach activities. Dr. Hodes visited Minneapolis with Dr. Petersen and Senator Amy Klobuchar, of Minnesota, and participated in both an open house and a town meeting. They appeared with advocates such as representatives of the Alzheimer's Association to discuss the importance of AD research and answer questions from members of the audience, which included people with general interests, academics, and some individuals with early-stage AD and their families. Senator Klobuchar and Drs. Hodes and Petersen then went to Rochester to tour a facility focused on neuroimaging, with several opportunities to communicate with constituents. Dr. Hodes noted that the Senator had been well briefed and was knowledgeable on research and its potential applications. He reminded the Council of the effectiveness of this forum, and he encouraged Council members to promote these kinds of efforts when they are not working for the Federal government.
NIA communication efforts also are relying on electronic media. The redesigned NIA website should be online in the near future, and it will provide updated features, enhanced search capabilities, better resources, and increased outreach for researchers and health professionals. In addition, NIA will increase its email alerts and direct mailings, increase awareness for the revamped Spotlight on Aging Research newsletter, and discuss research priorities and funding with organizations through newsletters and journals. Dr. Hodes closed by asking for help in conveying the significance of NIA activities and the importance of continued support.
In response to questions, Dr. Hodes reiterated that community visits can be the most effective forms of outreach. Often, NIH staff have no more than "sound bites" or "elevator moments" to communicate with Congress, whereas community visits offer opportunities for real communication and relationship building. Dr. Petersen added that Senator Klobuchar had requested a visit after attending a gala for the Alzheimer's Association and hearing remarks on relative funding for AD versus other diseases. He noted that the visit focused on ongoing research in Minnesota and proved to be rewarding for all. Mr. Daniel Perry noted that many Congressional briefings have been organized by advocacy groups, and he emphasized the importance and potential benefit of working with outside groups to organize outreach events, particularly in Congressional settings. Dr. Norman Anderson suggested that organizations spend time with NIA staff to determine the most important topics Congress needs to know about.
Dr. Hodes also noted the benefits of recognizing academic institutions within a district and pointed out that Senators or Representatives often take pride in their local institutions. Dr. Susan Swain pointed out that creating avenues of outreach is easier for someone if their university or medical center has a Center for Aging or something similar, and she asked whether some type of center designation could be established, in the absence of additional funds, to allow smaller groups to build relationships. Although Dr. Hodes was not sure centers could be designated without an attached funding mechanism, he did suggest that institutions aggressively highlight their achievements whenever they receive a center or large research award. Highlighting those local achievements can bring recognition to a representative and instill pride in local institutions.
Council members asked about the proposed National Center for Advancing Translational Sciences (NCATS) and the Cures Acceleration Network (CAN). Dr. Hodes reported that although some activities have been announced for NCATS, including a search for a director, the Center does not yet exist legislatively, because no appropriations have been made. The same is true for CAN.
A binder containing media coverage was circulated among Council members.
Future Meeting Dates
January 24–25, 2012 (Tuesday and Wednesday)
May 22–23, 2012 (Tuesday and Wednesday)
September 18–19, 2012 (Tuesday and Wednesday)
January 29–30, 2013 (Tuesday and Wednesday)
Consideration of Minutes of the Last Meeting
The minutes of the May 2011 meeting were considered. A motion was made, seconded, and passed unanimously to approve the minutes.
Dr. Terrie Wetle reported that the Task Force had focused primarily on the NIA Research Supplements to Promote Diversity in Health-Related Research (Diversity Supplement Awards). Notable alumni from this program include Dr. Raynard Kington, former Deputy Director at NIH; Dr. Felipe Sierra, Director of the NIA Division of Aging Biology (DAB); and Dr. Yvette Roubideaux, Director of the United States Indian Health Service.
The Diversity Supplement Awards began in the late 1980s with a series of NIH-sponsored regional meetings on minority representation in the biomedical and behavioral sciences. The first notice promoting supplements was published in 1989. The first program analysis was carried out in 2003, and in 2005 the program was expanded to include investigators with disabilities or from disadvantaged socioeconomic backgrounds. An analysis of program results from 2002 through 2009 shows that the NIA program has seen an increase in the number of female awardees, as well as an increase in the proportion of awardees supported for postdoctoral training. The largest proportion of awards has come from the Division of Behavioral and Social Research (DBSR) and the Division of Neuroscience (DN). The success rate on subsequent NIH applications from 2002 through 2009 appears to be relatively high, but when the Loan Repayment Program is excluded from the data, the success rate has averaged about 26 percent. The number of applications to all NIH Institutes and Centers (ICs) has grown over time, with the exception of a brief dip in NIA-funded applications in 2008.
NIA Diversity Supplement awardees have shown a considerable amount of success in obtaining funding from other government agencies, as well as from foundations and from their home institutions. They also have shown considerable productivity, with an average of 16 papers published and 8 papers on which they served as first author. All awardees have had publications both in the past 3 years and in the past 18 months, and these publications have been in high-quality journals. Eighty percent of awardees currently work in academic research institutions, and another 8 percent are in clinical practice. Thus, although the numbers are still small, the NIA Diversity Supplements appear to be working. They have supported a large number of promising researchers, served as an important step toward their independence as researchers, and contributed to their overall productivity. The 2002–2009 data, along with the data from the 2003 analysis, support a key role for this program to continue to advance and improve diversity in aging research.
During its meeting on the previous day, the Task Force heard presentations from two previous Diversity Supplement Awardees. Dr. Olivia Okereke, of Harvard University and the Brigham and Women's Hospital, discussed her work exploring the impact of diabetes, lifestyle factors, and insulin-like growth factor (IGF) on cognition. Dr. Okereke has gone on to receive pilot funding from the Harvard NeuroDiscovery Center to develop a shortened clinical dementia rating questionnaire; a K08 award to look at dietary fat composition, plasma lipids, and cognitive decline; and an R01 grant to study depression prevention in the Vitamin D and Omega-3 Trial. She has authored many publications, and she is highly skilled and productive. Dr. Kimberly Johnson, now an assistant professor at Duke University, used her Diversity Supplement Award to support formal training in a master's degree in health science, as well as informal training through conferences, national meetings, and faculty development. Her work explored why African Americans use hospice care at lower rates. Dr. Johnson has gone on to receive a Beeson K08 award and is now examining a framework to understand racial differences in hospice use, with a focus on system-wide and patient-level factors.
Dr. Wetle concluded her presentation by highlighting an NIA website that matches researchers with interested community members to improve communication, networking, and research quality.
Dr. Robert Califf asked about trends for African American men, who appear to be losing out in the academic race. Ms. Kate Nagy, who conducted that 2002–2009 analysis, responded that several African American men have received supplements and gone on to successful careers. She offered to send the data to Council members.
Dr. Eliseo Perez-Stable lauded the progress of the program and reiterated Task Force suggestions that NIH revisit the duration of these awards, even in light of the current budgetary climate. Dr. Wetle also reported on disappointment among the Task Force that more people had not applied for supplements and discussions of better ways to advertise the program. Dr. Robin Barr emphasized that the program analyses shows that the NIA Diversity Supplement Awards program works.
Dr. Wetle also reported on the recent activities of the NIH Council of Councils (CoC), which is responsible for advising the NIH Director on the policies and activities of the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI); serves as an external panel to IC Directors during the concept approval stage of the Common Fund/Roadmap initiative review process; and provides a second-level review of DPCPSI grants such as the Transformative R01 and the Early Independence Award.
Recently CoC has approved concepts in four areas:
- Catalyzing Translational Research by Increasing Metabolomic Research Capacity. Metabolomics is the systematic study of unique chemical fingerprints in specific cell processes. Because growth in this area has not kept pace with genomics or proteomics, NIH proposes a comprehensive resource center that provides high-quality data to researchers, trains a new generation of scientists, develops technologies and standards, and shares data and reagents.
- Single-cell Analysis. At present, most analyses use data aggregated across cells. This process tends to obscure heterogeneity and underlying dynamic states and limits the ability to measure individual components in complex systems. Advisory groups have recommended new biologic paradigms, novel approaches, toolkits for multimodal analysis to integrate disparate datasets, and validation and increased availability of existing technologies, all to understand and manipulate single-cells in situ.
- Human Heredity and Health in Africa (H3Africa). Although the ability to link genetic variation to disease predisposition is important to global health, African researchers and populations are underrepresented in global health endeavors. The proposed initiative aims to increase the number of African scientists and establish collaborative networks of African investigators across countries. It will create genomics research infrastructure, support genomics research activities linked to ongoing medical education partnerships in Africa, and support societal implications research. CoC was initially concerned about the amount of background information provided and the ability to invest in this area when NIH research funding has become severely limited overall. After reviewing additional information, however, the Council approved the concept.
- The National Center for Regenerative Medicine. This is an intramural research program focused on stem cell technology and therapy development. It will draw on the strengths of the NIH Clinical Center and provide opportunities for intramural/extramural partnerships in optimizing the generation of induced pluripotent cells from healthy and patient cohorts, develop standards for stem cell generation and distribution, bank and distribute cells, address policy and procedural issues, and advance therapy development.
Dr. Lisa Berkman reported that the working group considered one advisory meeting and one request for applications (RFA) concept clearance.
The advisory meeting, Advancing Alzheimer's Disease Preclinical Therapy Development, convened more than 60 participants from academia, the biotechnology and pharmaceutical industries, private foundations, NIH, and the U.S. Food and Drug Administration (FDA) to delineate areas of development necessary for the successful translation of AD drug efforts into the clinic. The meeting specifically focused on new research directions and technological investments, overcoming challenges associated with the use of animal models, and new public-private partnerships. Participants generated the following key recommendations:
- In light of the state of the AD research field, drug discovery, and clinical development, it is time to encourage and enable a paradigm shift toward a systems biology approach to basic research on AD, the neurobiology of aging, and drug discovery. NIA can learn from the National Institute of General Medical Sciences (NIGMS), the National Cancer Institute (NCI), and the National Institute of Allergy and Infectious Diseases (NIAID), all of which have supported similar approaches for basic research and therapy development.
- Endorse the Alzheimer's Drug Discovery Foundation's guidelines for preclinical efficacy testing. These guidelines were developed in collaboration with NIA and other groups.
- Develop resources and infrastructure to characterize existing and new animal models to be used for translation of AD research and to develop preclinical biomarkers. These resources should follow rigorous and standard preclinical efficacy testing guidelines.
- Provide more extensive training in the science of drug discovery and translational research.
- Extend collaborations with private foundations to close funding gaps.
Dr. Suzana Petanceska, who provided NACA with highlights of the advisory meeting, reiterated the participants' emphasis that addressing these recommendations will exceed the funding capacity of NIA. Thus partnerships between NIA and industry and private foundations were encouraged.
The Council discussion focused on the inadequacy of animal models for neurodegenerative diseases. Dr. Lennart Mucke pointed out that animal models are designed to dissect diseases and look at specific factors, but many people expect these models to simulate the complexity of disease and have difficulty changing their hypotheses based on models. He suggested that compound models might be more predictive for AD and other neurodegenerative diseases.
Council members also noted meeting participants' discussion of the lack of rigor in clinical trials [Did this comment refer to lack of rigor in human clinical trials or in preclinical animal studies?]. Dr. Califf indicated that information and reproducibility of data are important factors. Many trials are designed based on an inadequate or selective understanding of data from preclinical animal models. On the basis of his own experiences in examining research reproducibility, Dr. Califf noted the need for an informatics infrastructure for animal models and preclinical studies, an infrastructure that allows investigators to move back and forth between animal models and clinical studies. Dr. Arlan Richardson added that this problem is not unique to aging research. For example, studies of increased lifespan are usually done under refined conditions. Dr. Richardson highlighted a DAB program in which three different sites test an intervention in animal models.
Dr. Hodes commented that even if studies are well conducted and reproducible, heterogeneity in strain remains a concern. Recent reports examining genetic heterogeneity among animal models used in lifespan studies found that calorie restriction, hypothesized to extend lifespan, did so only in a third of the mouse strains tested. Another third showed no effect, and the remaining third actually showed a decrease. Thus paradigms that have been in place for decades should be considered with care.
A motion to approve the recommendations from the advisory meeting was forwarded and seconded. The motion passed unanimously.
Dr. Berkman also reported that the Working Group considered and recommended approval to renew the AD Cooperative Study (ADCS), a clinical trial consortium that is one of NIA's largest signature programs. ADCS supports the development of new evaluation instruments for clinical trials and of novel and innovative approaches to clinical trial design. The 5-year renewal would cover years 22 through 26.
Dr. Hugh Hendrie commended NIA on including non-pharmacological approaches and mild cognitive impairment in ADCS studies. A motion to approve renewal of ADCS was forwarded and seconded. The motion passed with one abstention.
The Working Group also discussed the need to develop and nurture the interface between researchers focused on neurodegenerative disorders and those focused on the basic biology of aging. Specific recommendations included workshops to bring investigators together; RFAs focused on questions such as how to introduce aging into models of neurodegenerative disease or whether anti-aging factors can stall or block cascades underlying disease; creation of a resource enabling a greater focus on aging and neurodegenerative disease, for example a repository of aged mouse models that simulate key aspects of neurodegenerative diseases; and extension of these initiatives to other ICs and age-related conditions. Council members acknowledged ongoing dialogue between the two groups at NIA, but they called for more to be done in the larger scientific community.
In response to questions from Dr. Wetle, Dr. Mucke, who participated in drafting these recommendations, noted that an animal model repository is especially important in light of calls for more rigorous preclinical studies. He also pointed out that such a repository will require more resources than one institution can provide and that a committee will be needed to examine complex models, decide which ones are most useful, and determine how to distribute them. The cost and investment of housing and aging mouse models can be a challenge, however. On the basis of experiences with an NIA-supported mutant mouse colony, a staff member suggested that an animal model repository will require a mechanism that ties the resource to its actual use, rather than age mice with the hopes that someone will use them. Dr. Swain agreed and suggested that the Council could encourage further consideration of the expenses, the inefficiencies associated with individual investigators developing models on their own, and the challenges of aging animals. She also suggested cellular aging as a field where a demonstration project could bring together researchers from different disciplines.
Dr. Barr summarized that the Council recommended the encouragement and acceleration of existing NIA efforts to integrate work on aging biology with basic research in neurodegenerative disease, as well as the consideration of aged animal models in targeting neurodegenerative disease. Workshops, RFAs, and other strategies will be considered. A motion to approve these recommendations was forwarded and seconded. The motion passed unanimously.
Dr. Hodes acknowledged the service of four outgoing Council members: Dr. Berkman, Dr. Dale Bredesen, Dr. James Smith, and Dr. Swain.
- Dr. Berkman commented that NIA has been a broad-minded, open, and innovative institution and that serving on the Council has been a pleasure.
- Dr. Bredesen considered it an honor to serve on the Council, and he has enjoyed his time on the Council. He noted that the Council and NIA are filled with intelligent, committed, and responsible people but that wrestling with old age remains a challenge. He encouraged NIA and the Council to continue to do whatever is necessary to convince the Government and the general public that the support of aging research is a critical priority.
- Dr. Smith ranked his service on the Council as among his most enjoyable NIH activities. He has been able to listen to science at the highest level and has talked with people with whom he would not have had interactions with otherwise. He thanked NIA for the opportunity.
- Dr. Swain noted her long professional relationship with Dr. Hodes and spoke of her retirement from the Council as a bittersweet moment. She further acknowledged that the field of aging research has come a long way and is now an exciting field with a large amount of depth in different areas. She concluded that aging research is one area where multidisciplinary researchers will hold together and have an impact on other fields.
Dr. Petersen reminded the Council that a subcommittee had been charged with examining NIA's review process because such a review had not been done before. The subcommittee met with the Scientific Review Branch (SRB) to identify issues, then further discussed those issues among themselves and in individual interviews with Division directors. The subcommittee also reviewed data provided by the Institute.
Overall, Division directors considered their relationship with SRB to be very good, and some said that this relationship had improved substantially during recent years. The directors also considered SRB to be doing an excellent job. Scientific review officers believed that at times the Divisions did not regard them as scientists, but as administrators. However, this was not the perception of Division directors. Rapport between scientific review officers and program officers was generally good, and program officers generally believed that the best reviews are taking place. The Divisions particularly appreciated the scientific review officers' workload and efforts to maintain high-quality reviews, especially in light of funding constraints and during the 2 years of American Recovery and Reinvestment Act (ARRA) funding.
SRB staff requested consideration of more funds to attend scientific meetings in order to stay current and to network. This request was endorsed by the Division directors and the Council subcommittee. Scientific review officers also wanted more input on the acceptance of some grants, such as initially unclaimed grants that were assigned to NIA but peripheral to the Institute's mission. In addition, although the officers acknowledged the need for a firewall between their branch and others within NIA, they wanted to participate in more NIA activities such as retreats, program planning, and funding opportunity announcements.
Opinions about Program Project (P01) reviews were mixed, and this process is still evolving. Some scientific review officers questioned whether P01 applications should undergo an initial review by Special Emphasis Panels (SEPs) prior to review by a parent committee with representation from all Divisions. Staff also noted that P01s formed a major portion of the portfolio in some Divisions but were hardly used in others.
The composition of review panels also was raised during the SRB review. Both Branch staff and Division directors observed that applications were reviewed by relatively junior investigators, but SRB would have to send several inquiries before it could find someone willing to accept a position on a panel. Scientific review officers noted that this is an area where traveling to scientific meetings and networking would be helpful. Building in incentives for senior investigators to participate on review panels also was suggested.
Scientific review officers also expressed that R03 applications should be reviewed by NIA. R03 reviews were transferred to the Center for Scientific Review (CSR) a few years ago, when SRB was overwhelmed by the number of R03 applications. However, SRB staff commented that there is not enough expertise on aging research or that CSR treats R03 applications similarly to R01s, either of which is detrimental to the review of aging applications.
On the basis of these interviews, the Council subcommittee concluded that SRB is functioning at a high level. The subcommittee concluded that the scientific contributions of SRB staff are appreciated, but also noted integration of this staff into NIA activities as an important issue. It further called for ongoing monitoring of communication between SRB and the rest of NIA, and, in agreement with SRB staff, recommended periodic reviews of SRB. The subcommittee also agreed that R03 reviews should be brought back to NIA and that increased travel budgets for SRB should be considered.
In response to further questions about P01 reviews, Dr. Hodes reminded Council members that the current process of percentiling P01 applications against CSR is not working. Because P01s are evaluated in ad hoc reviews, and because so many applications receive good scores, a large majority of P01 applications are scored in a compressed range. Judgments about single- versus dual-level reviews will be made once the outcomes from several council rounds of single-level reviews where P01s are not percentiled against CSR are known. However, a dual-level review would resemble the process used by the National Heart, Lung, and Blood Institute (NHLBI), where the ad hoc panel would conduct a primary review with narratives, but no scores, and a parent committee would accept the subject matter expertise of the ad hoc panel but assign scores based on the strengths of the overall program project. Dr. Hodes noted that the Council would be informed of any decision about the review process, but he invited Council members to provide input before any changes were made.
Dr. Ramesh Vemuri, SRB Chief, reported that when the issue first arose, the Branch staff visited different ICs and identified two workable models. In the NHLBI model, the investigators send information 4 months before the application is submitted and the review process begins 2 months before, when abstracts on key personnel are submitted. A member of the initial review committee reports to the parent committee, and half the applications are unscored. In the CSR model, all information is submitted to the parent committee, and the first level does not provide a score. However, Dr. Vemuri noted that the second level was more general and that first-level reviewer, who might have more specific expertise, often felt frustrated and eventually dropped out of the review process. He asked NIA to consider the constraints and limitations of each system before choosing one to use.
Dr. Berkman expressed concerns that a dual-review system would place applicants in "double jeopardy," especially if the parent committee review is not a true peer review. Dr. Mucke suggested a process whereby one or two members of the study section would participate in the site visit then discuss the initial review with the parent committee. In this way, the two reviews would be integrated. Drs. Swain and Richardson pointed out the difficulty of reviewing one project without knowing about the others, and they suggested a process where members of each Division rank applications within their own divisions. Other Council members suggested a process by which the first level would score projects based on enthusiasm, whereas the second level would evaluate overall impact. There were mixed opinions about whether NIA should have one multidisciplinary parent committee or a separate parent committee for each discipline. Dr. Mucke also suggested soliciting additional input from the field (e.g., the principal investigators on existing P01s), because these investigators might have good ideas on ways to improve review and are nervous about any changes that might be made.
Dr. Barr summarized the SRB review subcommittee's recommendations to review travel budgets for SRB officers, bring R03 reviews back into NIA, and continue to discuss how P01 reviews can improve. A motion to accept these recommendations was forwarded and seconded. The motion passed unanimously.
Dr. Lawrence Tabak, Principal Deputy Director, NIH, noted that diversity programs at NIH aim to attract the best and brightest scientists into biomedical and behavioral research. He emphasized that these programs were designed not as social engineering but toward creating the best scientific workforce. Despite these efforts, the impact on the diversity of the NIH-funded workforce has been disappointing. In 2008, African Americans constituted 10 percent of the U.S. population, and Latinos 12 percent, but they only represented 1.2 percent and 3.4 percent, respectively, of funded principal investigators. Even among full-time medical school faculty, only 2.9 percent are African American and 4.3 percent are Latino.
To address these shortfalls, NIH has commissioned several studies. One, an evaluation of education and career outcomes, with implications for policy, has been published online by the Social Science Research Network. Another, which summarizes sex differences in application, success, and funding rates for extramural NIH programs, has shown slightly less success for applications from women. Dr. Tabak focused his presentation on a study recently published in Science on race, ethnicity, and research awards (19 August 2011, Vol. 333, no. 6045: 1015-1019).
In this study, Ginther and colleagues assessed the probability of securing first-time R01 funding from 2000 through 2006 by Ph.D. investigators, controlling for observable characteristics such as NIH training, research experience, and home institutions. Of approximately 83,000 applications submitted by 40,000 unique Ph.D. investigators, only 1,149 were submitted by black or African American investigators. Assuming an award rate similar to those seen among white applicants, 357 of these applications would have been funded. However, only 185 were awarded. The scores and rate of pay decisions by ICs were similar among groups, suggesting differences at the level of peer review. Award probabilities were correlated with the NIH funding rank of the applicants' institution. Yet even among the top 30 NIH-supported organizations, black or African American applicants had the lowest award probability. In addition, black/African American and Latino applicants were less likely to resubmit applications, which are particularly critical in a constrained funding environment, when applications are rarely awarded on the first attempt. Moreover, participation in NIH-supported training or career development programs had a positive effect on R01 award rates, but much more for white applicants than for black or African American applicants.
In an accompanying commentary published in Science, Dr. Tabak and Dr. Francis Collins, NIH Director, declared the findings to be unacceptable, and they go on to describe NIH's continued commitment to a diverse biomedical workforce, additional analyses that have been conducted, and steps to seek out causes of racial and ethnic differences in awards. The agency is engaging in vigorous communication with all stakeholders, with the understanding that the problem will not be solved overnight. Because review experience correlates with success, NIH has established an Early Career Reviewers program, which will increase both the diversity of review panels and the exposure of investigators from diverse institutions to the review process. NIH also will conduct experiments to identify sources of bias, for example by de-identifying applications; testing reviewers' ability to determine applicants' race even on de-identified applications; assessing different types and timing of training against bias; and using validated tools such as Project Implicit. NIH also will assess whether the proportion of underrepresented minorities on review committees affect outcomes and will work with academic institutions to create pre-application mentoring programs for junior faculty. NIH has funded several extramural grants to study interventions that can strengthen the pipeline in a way to improve workforce diversity, and it has established both internal and external committees focused on diversity in the biomedical research workforce.
In response to questions from the Council, Dr. Tabak noted that the Ginther study analyzed data in aggregate form but looked at scientific fields as assessed by study sections. The study sections did not show differential success rates, but Dr. Tabak noted that the vast majority, if not all, of black and African American applicants submitted applications in behavioral sciences, particularly in the area of health disparities. Almost none of these applicants submitted applications in the basic sciences. In response to questions from Dr. Andrea LaCroix, Dr. Tabak noted that the data did not parse out first-time applicants.
Dr. Perez-Stable noted that although the distributions reported by Dr. Tabak are instructive, they are not exact. For example, the category "Other/Unknown" tends to include people of color, many of whom are biracial. Dr. Perez-Stable suggested that NIH pay more attention to Census groupings to understand which groups are really affected. He further pointed out that although the success rates get the most headlines, the number of African Americans and Latinos submitting applications is equally disappointing and deserves just as much emphasis. Dr. Perez-Stable also noted the emphasis on Ph.D. investigators and the need to look more at M.D.s and social scientists. Dr. Tabak agreed, and elaborated that the number of applicants self-identifying as "Other" is increasing and that the "Other" category is doing as well as white applicants. However, he also noted that an informal analysis of M.D.s found similar trends and that people of color tend to choose careers in the community, rather than careers in academic research.
Dr. Anderson was troubled that differences still exist even after data are controlled for "reputational issues" such as institution, publications, and grant experience, and he emphasized that NIH will have to address both issues with the pipeline and those with differential success rates. However, he commended NIH for taking this issue seriously and for looking at the levels of individual investigator, reviewer, and system. Dr. Anderson particularly acknowledged the inclusion of Project Implicit and noted evidence that just taking that test increases awareness and is beneficial. He further suggested that NIH also look to the Institute of Medicine report on differences in health care, as well as to research on housing audits or salary differentials, for ideas.
Dr. LaCroix noted the frustration of many young applicants, who are likely to have their applications rejected, and she feared that many would become so ungratified that they would choose a different career path. She also noted that the review process often rewards investigators for selling themselves, rather than their project. Drawing on her experiences in mentoring junior faculty who were first-generation college graduates, Dr. LaCroix further pointed out challenges faced by mentors attempting to overcome lack of preparation, for example in writing skills. Dr. Tabak and other Council members agreed that mentorship, though critical, is becoming increasingly difficult at the local and institution level. In some places, formal and rigorous mentoring programs do not exist.
Dr. Richard Suzman, Director of the Division of Behavioral and Social Research (DBSR) added that having access to an experienced co-principal investigator can be critically helpful; this might therefore be a place for NIH intervention and encouragement. Dr. Suzman also noted that many applications from minority applicants may be more problem-oriented rather than driven by scientific issues and so may not be seen as at the cutting edge of research.
In response to questions from Dr. Marie Bernard, NIA Deputy Director, Dr. Tabak explained that the Early Career Reviewers program looks for a strong record of high-quality publications but not necessarily for a history of NIH funding. He added that NIH wants to reach out to a more diverse group of institutions to find faculty who are also strong scientists, and he encouraged Council members to suggest such faculty from their own institutions.
In both humans and monkeys, increasing age is associated with impairments in working memory, multitasking, insight, decision making, and other executive functions, as well as with an increased susceptibility to interference. Yet in the information age, these functions are becoming even more important as tasks such as career maintenance, financial management, and medication administration become increasingly complex. Dr. Amy Arnsten, of the Yale University School of Medicine, described work focused on the prefrontal cortex (PFC) of the brain, where executive functions occur.
Studies in rhesus monkeys have shown that the higher functions in the PFC arise from neuronal networks that excite each other. In highly evolved circuits, these layer 3 networks connect at the synapse, in long, thin spines, and allow gating, and it is these spines that are most vulnerable to normal aging. Dr. Arnsten and colleagues have used a spatial working memory task to further examine the physiology of the aged PFC. They have identified two populations of cells in the PFC: cue cells, which fire specifically to a cue when it comes on, through bottom-up stimulation; and delay cells, a unique population of cells that fire to that cue but keep firing during the delay period, stimulated by their networks to keep that cue in mind. The delay cells, which fire only in the direction of that specific cue, undergo robust memory-related firing in younger monkeys, but this firing is dramatically reduced with age. Thus, the ability to discriminate what should be remembered from what should not be declines with age. However, cue-cell firing and bottom-up processing remain intact.
Biochemical data suggest that the loss in the memory-related firing of delay cells arises from dysregulation of cyclic adenosine monophosphate (cAMP) signaling. Stress or fatigue promotes production of cAMP, and potassium channels open gating network connections so that persistent firing drops. In the younger brain, the elimination of cAMP by the stress enzyme PDE4A and further inhibition of cAMP by alpha 2A receptors restore control of signaling and re-establish network connections. In the older brain, however, PDE4A and alpha 2A receptors are lost. In addition, PDE4A is expressed in the necks of long, thin spines, where gating and potassium channels are found, and other cAMP signaling proteins are expressed in these spines.
Dr. Arnsten's group has further shown that administration of the drug guanfacine, which stimulates alpha 2A receptors, can inhibit cAMP production and increase network firing. These findings are consistent with other work showing that systemic administration of guanfacine improves behavior, working memory, and resistance to interference. Although guanfacine has been on the market to treat hypertension, it also has been approved by the FDA for the treatment of attention-deficit-hyperactivity disorder, and increasing evidence suggests a benefit of guanfacine in treating Tourette's syndrome, autism, traumatic brain injury affecting the PFC, strokes, and emergent delirium related to anesthesia. Further work is under way to determine whether this drug can improve PFC functions in older people.
In response to questions from the Council, Dr. Arnsten speculated that cellular age might play a role in age-associated declines in executive function. It is not clear, however, whether there is heterogeneity in effective aging among monkeys as has been seen in rodents. Nor is it clear whether age-associated dysregulation of cAMP signaling is a disease process or a time-related phenomenon similar to radioactive decay.
- Division of Behavioral and Social Research (DBSR): The Oregon Health Insurance Experiment: Evidence from the First Year
In 2008, the State of Oregon used a lottery system to randomly enroll uninsured residents into its Medicaid program. Approximately 85,000 applicants signed up for the lottery during a 5-week period, and of those, about 30,000 were selected and asked to provide additional information on income, assets, and citizenship. The Oregon Health Insurance Study, an ARRA-funded study, assessed the effects of enrollment on use of services, health outcomes, and financial outcomes. Dr. Joseph P. Newhouse, of the Harvard Medical School Department of Health Care Policy, presented data from the first year of the study.
Only 60 percent of lottery winners responded to requests for more information on assets, income, and citizenship, and only half met eligibility criteria for the Oregon Medicaid program. Slightly more than half of the lottery winners were female, and there was a wide age distribution. Chronic disease and depression were prevalent, and half of the winners did not work. Enrollment in Medicaid was associated with increases in use of preventive care, outpatient visits, and rates of hospitalization, suggesting a 25 percent increase in health care spending. Enrollment did not appear to have an effect on emergency room visits. The study is not sufficiently powered to examine effects on mortality, but first-year data suggest substantial effects on self-reported health. The proportion of individuals reporting good or very good health was higher by 13 percent in the Medicaid group, and the number of days of reported good health was higher by 5 percent. Effects on financial strain were not apparent except for a 10 percent reduction among the Medicaid group in terms of collections related to medical debt.
Dr. Newhouse noted that although enrollment of uninsured persons into Medicaid was associated with substantial improvement in self-reported physical and mental health, about two-thirds of these health gains occurred almost immediately. It is not clear then whether the observed gains merely reflect a general decrease in anxiety. In addition, the study population is similar to the population targeted by the Affordable Care Act Medicaid Expansion, but it is not fully representative of the U.S. population. Further clinical measures have been taken and will be included in future results.
In response to questions from Dr. Hendrie, Dr. Newhouse clarified that hospitalization rates increased by 30 percent and length of stays by 20 percent in the Medicaid group. There also appeared to be a large increase in the number of procedures. However, Dr. Newhouse speculated that this effect might be transient and that hospitalization rates may actually decrease overall the longer individuals are in the Medicaid program.
Dr. Smith pointed out that self-reports on health are subjective and that the observed effects could simply arise from a better feeling about life. Dr. Newhouse acknowledged the subjective nature of these reports, but he added that study measures also include more objective questions about activities of daily living, as well as a physical health scale. He further noted that this study differed from a RAND study which was the only other randomized health insurance study done in a developed country. Compared with that study, the Oregon Health Insurance Study population is a more disadvantaged population with a wider age distribution. All have income under 100 percent of the Federal poverty level, many have no supportive partners or real health providers, and many face severe financial stress, possibly as a result of poor health.
In response to questions from Dr. Perez-Stable, Dr. Newhouse noted that most of the increased hospitalizations appear to be associated with heart disease. As a result of enrollment in Medicaid, many patients were seeing a doctor for the first time, and concerned doctors were sending them to the hospital. Dr. Newhouse added that most of these patients had been able to access medical care under the safety net before. He further indicated that many in the control group reported a usual source of care but that the number increased substantially in the treatment group.
Dr. Stephanie Studenski asked whether information is available on study participants prior to their selection in the lottery, and she expressed concern that failure to randomize participants to a new health care benefit could result in declines in perceived health or actual harms. Dr. Newhouse responded that little information was available on participants prior to the lottery. He further noted that study investigators were actually concerned that improvements in perceived health would arise simply from participants winning the lottery. It is not clear whether such an effect will persist.
- Division of Aging Biology (DAB): Starvation and Substitution Diets to Enhance Cancer Treatment
Dr. Valter Longo, of the University of Southern California School of Gerontology, described work in which results from yeast studies were further explored in other models and in clinical trials. Studies of yeast have shown that yeast cells switched from glucose-rich medium to starvation medium become protected against many toxins. Many of the genes controlling starvation-dependent protection are orthologs of human oncogenes, suggesting that starvation might protect normal cells from chemotherapy. This hypothesis would further suggest that cancer cells will not receive such protection because of oncogene mutations.
In a proof-of-principle study, Dr. Longo and colleagues found that a cancer-like yeast strain was killed by treatment with a chemotherapy drug, but normal yeast strains were not. These results were consistent with mouse studies in which starvation for 48 to 72 hours protected normal cells, but not cancer cells, from drugs such as etoposide, cisplatin, and doxorubicin. Further studies in mice demonstrated a role for glucose levels and expression of insulin-like growth factor 1 (IGF-1). In normal cells, stress response is associated with a reduction in glucose and IGF-1 levels, resulting in a downregulation of many proto-oncogenic pathways. However, although glucose and IGF-1 levels are reduced in cancer cells, oncogenic mutations likely prevent the stress-associated downregulation of oncogenic pathways, and these cells thus remain sensitive to chemotherapy. Studies are under way to determine whether starvation actively worsens conditions for cancer cells.
Anecdotal evidence suggests that patients who combine starvation with chemotherapy feel better and experience fewer side effects associated with therapy. However, a starvation time of 48 to 72 hours in mice translates to 5 days in humans, which is not feasible. In a company supported partly by the National Cancer Institute, through a Small Business Innovation Research grant, Dr. Longo and colleagues have developed a substitution diet based on yeast and animal studies, such that patients can receive the benefits of fasting without the risk for undernourishment. A clinical trial of this diet is planned.
In response to questions from Dr. Swain, Dr. Longo noted that fasting and chemotherapy must be timed precisely, because IGF-1 levels rebound fairly rapidly once a normal diet is reinstated. Dr. Hodes cited Dr. Longo's work as an example of the ingenuity of investigators in making connections and translating results in an orderly way.
- Division of Geriatrics and Clinical Gerontology: The Role of Vitamin D—Recent Perspectives
Vitamin D intake occurs both from diet and from absorption through the skin from ultraviolet light in the sun. Once in the body, vitamin D travels to the liver and is converted to 25-hydroxyvitamin D (25OHD), which is what is measured in the clinic. This metabolite travels to the kidney, where it is further converted into 1,25-dihydroxyvitamin D. However, there is also a catalytic step between 25OHD and 1,25-dihydroxyvitamin D that results in an inactive metabolite.
Each measurement of 25OHD costs about $150; thus population screening for vitamin D deficiencies has become a billion-dollar industry. Yet vitamin D is clinically problematic, because definitions of normal levels, insufficiency, and deficiency in vitamin D differ among groups. The Endocrine Society recommends a threshold level of 30 ng/ml, whereas the Institute of Medicine (IOM) and the World Health Organization (WHO) recommend a threshold level of 20 ng/ml. Moreover, the ability to determine whether someone has a vitamin D deficiency differs depending on whether measurements are taken in the winter or summer.
On the basis of an extensive review and an Agency for Healthcare Research and Quality (AHRQ) report by the Tufts Evidence-based Practice Center, the IOM has issued new guidelines on vitamin D and calcium intake. The report found implications for vitamin D deficiency not only in poorer bone health, but also in poorer physical performance and in diseases and conditions including cardiovascular disease, cancer, diabetes, and immune disorders. However, the report also found that the majority of findings regarding vitamin D, calcium, or the combination are inconsistent, making it impossible to establish dose-response relationships among intake of vitamin D, calcium, or both.
Dr. John Gallagher, of the Creighton University Medical Center, discussed the IOM/AHRQ review and the rationale for the Endocrine Society and IOM guidelines. He noted that the Endocrine Society recommended a threshold of 30 ng/ml because of suggestions that serum parathyroid hormone (PTH) plateaus at a serum 25OHD level of 30 ng/ml, that calcium absorption shows a threshold response at 32 ng/ml 25OHD, and that a serum 25OHD level above 24 ng/ml is necessary to prevent falls. However, across 70 worldwide studies, the AHRQ review found no consistent level of serum 25OHD associated with a PTH plateau. With respect to threshold effects in calcium absorption, more than 1,000 papers showed no threshold effects, and 1 paper included a theoretical point, rather than a measurement. When this theoretical point was removed, the threshold for calcium absorption was approximately 15 to 20 ng/ml 25OHD. Moreover, doses were not aligned correctly in the paper suggesting a threshold of 24 ng/ml, and further analysis by the IOM found that the effect of vitamin D on falls is nonsignificant.
The quality of data has been poor, and the majority of studies reviewed by the IOM and AHRQ have focused on vitamin D and calcium, not on vitamin D alone. However, evidence does support a serum 25OHD threshold of 20 ng/ml to define vitamin D insufficiency. For example, several studies have shown a significant increase in hip fractures only below 20 ng/ml. In addition, enough data were available for meta-analyses, which supported a recommended daily allowance of 400 units of vitamin D in individuals aged 50 years or older. A clinical trial is under way to further assess the vitamin D dose needed to achieve a serum 25OHD level of 20 ng/ml.
In response to questions from the Council, Dr. Gallagher speculated that in the United States, individuals' vitamin D levels would be low only during the fall and winter months, when there is less exposure to the sun, but this should be studied further. Otherwise, the implications of the IOM guidelines on vitamin D screening are not yet clear.
The open session of the 114th meeting of the National Advisory Council on Aging adjourned at 1:20 p.m. on September 21, 2011. The next meeting is scheduled for January 24–25, 2012.
I hereby certify that, to the best of my knowledge, the foregoing minutes and attachments are accurate and complete.3
Prepared by Robin Barr, D.Phil.
With assistance by Rose Li and Associates, Inc.
- For the record, it is noted that members absented themselves from the meeting when the Council discussed applications (a) from their respective institutions or (b) in which a conflict of interest may have occurred. This procedure only applied to applications that were discussed individually, not to "en bloc" actions. (Back to text.)
- For the record, it is noted that members absented themselves from the meeting when the Council discussed applications (a) from their respective institutions or (b) in which a conflict of interest may have occurred. This procedure only applied to applications that were discussed individually, not to "en bloc" actions. (Back to text.)
- These minutes will be approved formally by the Council at the next meeting on May 24–25, 2011, and corrections or notations will be stated in the minutes of that meeting. (Back to text.)
Attachment A: Roster of the National Advisory Council on Aging
(Terms end December 31) (*Member WGoP)
Richard J. Hodes, M.D.
Director, National Institute on Aging
National Institutes of Health
Bethesda, MD 20892
Norman B. Anderson, Ph.D. (2014)
Chief Executive Officer and Executive Vice President
American Psychological Association
Washington, DC 20002
Lisa F. Berkman, Ph.D. (2011)
Director and Professor
Harvard School of Public Health
Department of Society, Human Development, and Health, and Department of Epidemiology
Cambridge, MA 02138
Dale E. Bredesen, M.D. (2011)
Buck Institute for Age Research
Novato, CA 94945
Robert M. Califf, M.D. (2013)
Vice Chancellor for Clinical Research
Duke University
Director, Duke Translational Medicine Institute
Durham, NC 27710
*Hugh C. Hendrie, DSC, Ph.D. (2013)
Professor of Psychiatry
Indiana University School of Medicine and Regenstrief Institute, Inc.
Indiana University Center for Aging Research
Indianapolis, IN 46202
*Andrea Z. LaCroix, Ph.D., MPH (2012)
Fred Hutchinson Cancer Research Center
Women's Health Initiative Clinical Coordinating Center
Seattle, WA 98109
Richard I. Morimoto, Ph.D. (2014)
Bill and Gayle Cook Professor of Biology
Departments of Biochemistry, Molecular, and Cell Biology
Northwestern University
Evanston, IL 60208
Victor Molinari, Ph.D. (2012)
University of South Florida
Department of Aging and Mental Health
Tampa, FL 33612
*Lennart Mucke, M.D. (2012)
Department of Neurology
University of California, San Francisco
San Francisco, CA 94141
Eliseo J. Perez-Stable, M.D. (2014)
Department of Medicine
University of California
School of Medicine
San Francisco, CA 94143
Daniel P. Perry (2013)
Executive Director
Alliance for Aging Research
Washington, DC 20006
Ronald C. Petersen, Ph.D., M.D. (2013)
Department of Neurology
Mayo Clinic College of Medicine
Rochester, MN 55905
Arlan G. Richardson, Ph.D. (2013)
Barshop Institute on Longevity and Aging Studies
University of Texas Health Science Center
San Antonio, TX 78245
June Simmons (2012)
Chief Executive Officer
Partners in Care Foundation
San Fernando, CA 91340
James P. Smith, Ph.D. (2011)
Senior Economist
Rand Corporation
Department of Labor and Population
Santa Monica, CA 90407
Stephanie A. Studenski, MPH, M.D. (2014)
Department of Medicine
University of Pittsburgh
Pittsburgh, PA 15213
Susan L. Swain, Ph.D. (2011)
Department of Pathology
University of Massachusetts Medical School
Worcester, MA 01655
*Terrie F. Wetle, Ph.D. (2013)
Associate Dean and Professor
Brown Medical School
Providence, RI 02912
Kathleen Sebelius
Department of Health and Human Services
Washington, DC 20202
Francis S. Collins, M.D., Ph.D.
National Institutes of Health
Public Health Service
Bethesda, MD 20892
James F. Burris, M.D.
Deputy Chief
Office of Research and Development
Department of Veterans Affairs
Washington, DC 20430
Kenneth G. Pugh, M.D.
Department of Medicine
National Naval Medical Center
Bethesda, MD 20889
John Wren
Office of Program Development
U.S. Administration of Aging
Washington, DC 20020
Robin A. Barr, D.Phil
Division of Extramural Activities
National Institute on Aging
Bethesda, MD 20892


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Praying Mantis Meanings in the Realms of Animal Symbolism
This is beautiful so I posted it. hope you like it and share. Our "Mission statement"
The mantis comes to us when we need peace, quiet and calm in our lives. Usually the mantis makes an appearance when we've flooded our lives with so much business, activity, or chaos that we can no longer hear the still small voice within us because of the external din we've created.
Greek,mantis = seer, prophet): praying mantids
After observing this creature for any length of time you can see why the symbolism of the praying mantis deals with stillness and patience. The mantis takes her time, and lives her life at her own silent pace.
These traits have lead the mantis to be a symbol of meditation and contemplation. In fact, in China, the mantis has long been honored for her mindful movements.
The mantis never makes a move unless she is 100% positive it is the right thing for her to do. This is a message to us to contemplate and be sure our minds and souls all agree together about the choices we are making in our lives.
Overwhelmingly in most cultures the mantis is a symbol of stillness. As such, she is an ambassador from the animal kingdom giving testimony to the benefits of meditation, and calming our minds.
An appearance from the mantis is a message to be still, go within, meditate, get quite and reach a place of calm. It may also a sign for you to be more mindful of the choices you are making and confirm that these choices are congruent.


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A network visualization that may help people in India get better eye care
What happens when TED Fellows converge? They cross-pollinate their unconventional approaches to help each other achieve big objectives. MAPPR is a cloud-based tool that makes creating network visualizations an easy task. This service is the brainchild of TED Fellows Eric Berlow, David Gurman and Kaustuv De Biswas, and it debuted at TED2014. At this conference, […]Continue reading


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NITI Aayog is finally fixing the loose ends with the construction matrix to allow the multiplier effect to breathe its magical effect across the economy. It is putting together a policy to remove hurdles for projects where contractors are locked in arbitration with government agencies so that 75 per cent of the funds would be released to banks in cases where there is unanimous award in favour of a contractor. This will help release funds and revive stalled projects. Close to Rs 3.6 lakh crore is locked up in such cases and banks will see their performance improve even if a part of the funds is released.
According to a survey by research agency Daksh, if one has a case pending in any of the subordinate courts in the country, the average time in which a decision is likely to be made is nearly six years. Even assuming that a case does not go to the Supreme Court, an average litigant who appeals to at least one higher court is likely to spend more than 10 years in court. Now, an underlying informal rule exists within the government department that is causing a huge bottleneck in judgements and awards. A large portion of the ´pending cases backlog´ originates from the fact that all judgements issued against government departments are appealed against, as a standard practice. This is so much of a hard rule that if a government officer does not follow suit, he fears that the Vigilance Commission may come after him. This not only delays justice, even in genuine cases, but clogs the judiciary system unnecessarily. Arbitration awards are also the victim of this informal ´standard rule´.
The new arbitration act has come into effect from October 23, 2015, which allows the awardee of the arbitration the fruits of the award after three months even though an application has been filed objecting to the award, unless the court issues a stay on the award. Considering almost Rs 3 lakh crore is stuck in disputes and arbitration (as per ASSOCHAM, it is closer to Rs 5 lakh crore; just consider that the amount stuck in arbitration and disputes with NHAI alone is Rs 23,000 crore), the new act may help resolve conflicts swiftly. But unless we arrest the root of the higher flow of arbitration cases, namely the ´standard rule´, we will be swimming against the tide.
Another factor strangulating growth is the escalating cost of land and delays caused in land acquisition. Data by the Ministry of Road Transport and Highways shows that during 2015-16, NHAI paid Rs 19,020 crore to acquire 9,285 hectare. This is the most it has paid out by way of compensation in one year compared to disbursements in the past five years. In the last fiscal, NDA paid an average of Rs 2 crore per hectare compared to Rs 1.35 crore per hectare in 2014-15.
Here, renting land for infrastructure projects is a viable and practical solution. It will help save capital by not requiring a large amount of money to be locked up and save time in purchase and the entire process of land acquisition, thereby fast-tracking projects. (According to recent estimates, the capex for land alone for road projects is Rs 185,000 crore.). Some industries already follow the model of leasing land instead of acquiring it. Oil and gas extraction and renewable energy projects usually follow the land-lease model. Land pooling used by Magarpatta city a decade ago and, more recently, by Andhra capital Amaravati, by CIDCO for the Navi Mumbai International Airport and by the Maharashtra Government for the Mumbai-Nagpur road corridor offer examples of how both delays and capex commitment can be lowered.
Indeed, it is time to unclog the arteries for the economic lifeblood to flow unfettered to make India vibrant and reach its growth goals.
And in this issue, understanding the growth goals across Tier-II and Tier-III cities, and consequently the growth in their building and design needs, the second decade and the 11th edition of the CW Architect and Builder Awards – CWAB 2.0 – introduced a whole new category of Noteworthy Projects. Through this category, we recognised the work being done across sectors – interiors, retail, commercial, residential, institutional and hospitality – and a whole new set of winners took centrestage with India´s Top Architects and Builders last month in Mumbai. These included winning projects from Anand, Surat, Calicut, etc.
And, as we pace up with the digital world, stay with us for daily news and updates on the magazine portal www.ConstructionWorld.in Let us also continue to be your single window to share your perspectives and voice your opinions and recommendations – and this time, its digital!


text: Go Barefoot is a trading name for The Barefoot Enterprise Ltd, a company registered in England with limited liability. Registered office: Handel House 95 High Street Middlesex HA8 7DB UK Reg. Number: 07850951. The Barefoot Enterprise Ltd is a UK based company and all contracts are subject to English law. © 2016 www.gobarefoot.travel - All Rights Reserved


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Nov 13e Two-Factor Authentication Now Available
We are happy to announce this long awaited security feature which is now available for all accounts as of today! Two-Factor Authentication (also known as 2FA) adds an additional layer of security by adding a second step to the login process. It takes something you know (i.e. your password) and adds a second factor, typically something you ... Lees verder »
Apr 1e New Web Hosting Packages Available!
Every business, whether its just getting started or well established, plans for growth. Your web hosting package should be able to grow with the needs of your business. For that reason, we at WebUnraveling have created new hosting packages that will suit the needs of many businesses. Hosting packages with us are easily upgradable at any time. If ... Lees verder »
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Jacira Paolino
Doug and Janie are the best!
Doug and Janie are the best! The first time I went in was a couple months before I actually purchased, to get some ideas, and Doug himself showed me around. When I was ready to move forward with my remodel, Janie did all the work - she made great suggestions, gave me tons of options and it turned out to be pretty much a one-stop shop as far as fixtures go. The delivery was prompt and Doug and Janie's son came with the shop's mascot a dog whose name is (I think!) Maui! The guys unloaded everything and stacked it in an orderly manor. All very professional, from start to finish. I know they've been doing this for a long time, but they've built their business by giving great customer service. I really do highly recommend Doug's Tubs!


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Write Brent Bozell
This column was reprinted by permission of L. Brent Bozell and Creators
Syndicate. To reprint this or any of his twice weekly syndicated columns, please contact Creators Syndicate at (310) 337-7003 ext. 110
Harvard vs. The Hood
Barack Obama's inauguration was an enormous magnet for the stars of stage, screen, TV, and the radio, the celebrity-stuffed culmination of the goals of the Sixties civil rights movement. Some of the most prominent stars were black musicians. This is an opportunity to raise the question: Whither goest black popular culture, especially hip-hop music, under the new president?
1. Will the Obama presidency drain the swamp of hip-hop hate? Can he remake the dividers into uniters? On Tuesday night, the rapper Jay-Z performed on the ABC Inaugural ball special in a tux and nerdy glasses, toning down the thug-rap with a song called "History." ABC didn't have to bleep a single word, even if the older demographics in the audience were still wondering why this is called music. Wouldn't it be wonderful if the pendulum of rap music swung away from glorifying the "thug life" of drug dealers, pimps, and gangsters? With a black man in the White House, could rappers be less pessimistic about authority? When talking about The Man, there is no more powerful man in Washington than the black man just sworn in as our 44th president.
The early signs aren't promising. On YouTube, Jay-Z and another rapper, Young Jeezy, appeared at a Monday night "Hip Hop Inaugural Ball" in Washington. They certainly weren't in the spirit of optimism and nonpartisanship. Jeezy proclaimed: "I wanna thank two people. I wanna thank the mother [profanity] overseas that threw two shoes at George Bush. Listen, listen! I wanna thank the mother [profanity] who helped them move their [profanity] up out of the White House...My president is mother [profanity] black!"
Jay-Z rapped: "You can keep ya puss, I don't want no more Bush / no more war, no more Iraq, no more white lies, my president is black!"
Looking at rappers like this, you really have to wonder if they really believe their own wealth-building bluster about how terrible America's been to them. What kind of dystopian country have these young black millionaires been living in? Jay-Z was born a few weeks before 1970, Young Jeezy was born in 1977. When they were growing up in the Carter and Reagan years, was America a land of apartheid and oppression? Sadly, some of the most successful hip-hop music thrives on an extreme of pessimism and despair, and spreads it, like poisoned peanut butter. But they never lived it.
2. Will Obama's rise shift black youth away from thug-rapper role models like 50 Cent and toward black high achievers? NBC's "Today" explored the "Harvard vs. Hood" debate over black role models. It was outrageous to find correspondent Jamie Gangel sympathetically painting the gangsta-rapper 50 Cent thusly: "Behind the trademark scowl and explicit lyrics is a smart, soft-spoken businessman who can be very different in private." He doesn't smoke, doesn't drink, she underlined. "Do you think you're misunderstood?" she asked hopefully.
After getting a nod, she changed the subject to commerce: "But he knows what sells. You scare people." 50 Cent agreed: "I know I scare people. That's actually my job. That's why they buy my music. I scare them for $16.99, and they--and they buy the records and they're entertained by it." Gangel suggested it was all unreal, and therefore innocent. Does this woman fail to understand this guy was a crack cocaine and heroin dealer before being "discovered" by Eminem?
Sadly, when Gangel proceeded to ask young blacks whether President Obama or 50 Cent would be a stronger role model, most picked the rapper, as one said, "because he's cool. I mean, he's what's in. Yes, the highest leadership position in American has changed, but society has still not changed yet." Another added: "I do think that the life experiences of 50 Cent cannot be dismissed, and I think a lot of African-Americans can relate to 50 Cent's experience."
This is where some fatherly fuddy-duddies are desperately needed. Would a "businessman" like 50 Cent have met the favor of Michelle Robinson's father before she brought home Barack? It's nice to visualize a tough old-school dad that would dare to look down his nose at a wildly successful gangsta rapper as more of a menace than a man.
These kids still tried to pay tribute to Obama -- by calling him "gangster." It's partially President Obama's fault. He's been very tight-lipped and cautious about disparaging rappers. He's done it only when pressed, and always with great caution and tributes to rap artistry. He's tried to display how he's down with hip hop. He has copied Jay-Z's moves and invited him to perform at a concert after the Inauguration for his staff party in Washington. What wonders he might work if President Obama would sound much more like Bill Cosby now that he's standing in a powerful bully pulpit. But who will press him to try it?
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McClures Beach, Point Reyes: McClures Beach Trailhead, San Francisco: Marin Headlands - Mt Tamalpais - Point Reyes, California
McClures Beach - 0.8 miles
Point Reyes: McClures Beach Trailhead
|Round-Trip Length:
|0.8 miles
|Start-End Elevation:
|287' - 0' (+287' total roundtrip elevation gain)
|Elevation Change:
|-287' net elevation loss (287' max elevation)
|Skill Level:
|Dogs Allowed:
|Bikes Allowed:
|Horses Allowed:
|Related Trails:
McClures Beach - 0.8 Miles Round-Trip
McClures Beach is the northern most accessible beach in Point Reyes National Seashore, an idyllic crescent framed by towering bluffs and pounding waves.
Distance from the main visitor center keeps crowds to a minimum in this tranquil corner of the Park. Swimming, wading and surfing are not permitted at McClures Beach due to strong surf and active White Shark populations just off shore.
Hazards notwithstanding this is arguably one of Point Reyes' most compelling beaches for its size, scenery and location:
The trail drops sharply from the parking area down a steep, narrow ravine and merges with another in .17 miles. The steep grade continues to the beach (.4 miles), where it spills into its approximate center.
The north end of McClures Beach is hemmed by outcrops, but a narrow slot on the south end - safely navigable at low tide - threads the bluffs and Elephant Rock to a secluded cove with sea stacks just offshore.
This secluded beach is narrow and has no alternative outlet, making accurate tide reading a must. Leave yourself plenty of time to negotiate the passage back to McClures Beach.
Sneaker Waves
Sneaker waves are known to occur on McClures Beach. Sneaker waves are defined as unusually large and powerful waves that reach much higher up the shore than normal waves. They may also carry debris with significant force onto the beach.
Sneaker waves cannot be predicted and may occur at any time of day, year, or interval; the only possible indication is a sudden lowering of the water level. Sneaker waves have caused several deaths in Point Reyes National Seashore. Beach goers are advised to stay 30 yards from the water, and keep children and pets within close range.
Interactive GPS Topo MapKey GPS Coordinates - DATUM WGS84
- N38 11.310 W122 57.492 — McClures Beach Trailhead
- N38 11.269 W122 57.832 — .4 miles : McClures Beach
Worth Noting
- Harbor Seal pupping season runs March - June. Remain at least 300' from colonies and report abandoned pups to Park Headquarters (415.464.5170).
- Great White Sharks are known to patrol the waters off McClures Beach. Surfing and swimming are not permitted.
- Tide pools dot natural jetties on the south end of McClures Beach near Elephant Rock. Be mindful of the surf at all times.
Camping and Backpacking Information
- Camping is not permitted on McClures Beach.
Rules and Regulations
- Wood fires are permitted on McClures Beach. Permits are required for any wood fire within the National Seashore. Permits are available at visitor centers, the dispatch office, and field rangers. Permits may only be obtained on the day of use. The permit is free. Permits are not available or valid during high fire danger periods, or on Spare The Air Days. For current beach fire information, call 415.464.5100 x2 x1.
- Wood fire locations: Wood fires are allowed only on beaches (below the high tide line, if possible), 30' or more from vegetation and other flammable material.
Directions to Trailhead
The McClures Beach Trailhead is located just west of the Pierce Point Ranch - Tomales Point Trail parking area.
From US 101 in Marin County, exit Sir Francis Drake/San Anselmo. Drive west on Sir Francis Drake about 20 miles to the junction with CA 1. Turn right for 0.1 miles then left onto Bear Valley Road. After about 2 miles Bear Valley Road ends at Sir Francis Drake; turn left. Continue on Sir Francis Drake about 5.5 miles, then turn right onto Pierce Point Road. Drive about 9 miles on Pierce Point Road to the cul de sac and parking area for Pierce Point Ranch. Just before entering the cul de sac look for signs (left) pointing to McClures Beach. Turn left for .3 miles down the winding access road to the McClures Beach parking area.
Contact Information
Point Reyes National Seashore
1 Bear Valley Rd.
Point Reyes Station, CA 94956
Visitor Information: 415.464.5100 x2 or 415.663.8522 x2
Headquarters: 415.464.5100 x 1
Volunteer Information: 415.464.5145
Education Programs: 415.464.5139
Special Use Permits: 415.464.5111
Fax: 415.663.8132