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Questions for ASCO – on Tamoxifen, ATLAS and aTTom
On Sunday in Chicago, oncologists and others at the plenary session of the annual ASCO meeting will be talking about an abstract that matters a lot to women with breast cancer. It's a study on Tamoxifen that bears on how long women with estrogen-receptor positive (ER+) tumors should take adjuvant hormonal therapy after initial treatment for early-stage BC.
Why this matters so much is that ER+ tumors account for most BC cases. So if you're a pre-menopausal woman who's had a tumor removed by surgery, there's a good chance your doctor will recommend adjuvant ("extra") treatment with Tamoxifen for 5 or (probably) 10 years. The reasoning behind this recommendation is that the recently-published ATLAS study demonstrated a clear lengthening of life among women with ER+ tumors who took the longer course.
The usual dose of Tamoxifen (Nolvadex) is 20 milligrams per day. The bargain-rate cost is around $9 for a month's supply GoodRx.com – so we're talking just over $110/year x 5 or 10 years. That's small change as oncology drugs go, although the numbers add up over so many patients affected…
Tamoxifen carries a small but real risk for what most doctors consider side effects, like blood clots and occasional, typically low-grade uterine cancers. The problem with Tamoxifen – which is not so much a risk as a definite consequence of taking this medication – is that it has anti-estrogen effects that many young (and older) women consider undesirable. Already our breasts have been cut. Feeling "feminine" is not trivial. Many don't want it!
(Mental exercise: imagine hundreds of thousands of men ages 35-55 agreeably accepting a prescription for partial chemical castration to reduce the chances of a tumor recurring, after they've already had significant treatment to reduce those odds)
Your author has been in rooms filled with doctors where the overwhelming consensus expressed was that hormonal treatments in women with BC are terrific. Indeed, they extend life and, in some cases – such as those with low Oncotype scores – afford women the option of skipping chemo. But how are they so sure we'd rather take an anti-estrogen for 5-10 years rather than 3-6 months of chemo? Answer: I don't think anyone knows.
One limitation of the ATLAS study (and as best I can tell the same for aTTom) is that the trial doesn't distinguish between women who got adjuvant chemo and those who didn't get chemo. So it's unclear whether Tamoxifen helps prevent recurrence, or extend life, in women who've also received chemotherapy for the disease.
Here are 2 questions for aTTom:
1. How do we know that women with small, node-negative (low risk) tumors who receive chemotherapy, as is standard in many communities, get additional benefit from Tamoxifen after chemo?
2. Should pre-menopausal women with small, ER+ tumors be given a choice between taking chemo or Tamoxifen?
In other words, is there evidence to support the combination – chemo followed by hormonal Rx – as the standard, adjuvant care for women with early-stage, ER+ tumors? or that women prefer hormonal pills over a short course, like 4 cycles, of chemo?
I'm eager to hear about the updated aTTom (adjuvant Tamoxifen Treatment offers more?) findings, to be published and presented on Sunday. I hope my colleagues – doctors, patients, advocates and journalists will ask good questions!
All for now,
Related Posts:
3 Comments
I am a 61 year old male breast cancer survivor. I had a mastectomy in July of 2012, followed by 4 rounds of chemo and I am now on Tamoxifen for almost a year. Did either the ATTOM or ATLAS trials include any male patients?
I am a 61 year old male breast cancer survivor. I had a mastectomy in July of 2012, followed by 4 rounds of chemo and I am now on Tamoxifen for almost a year. Did either the ATTOM or ATLAS trials include any male patients?


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A comet sailing through the inner solar system make its closest approach to the sun and will be at its brightest at sunset tonight, but the glare of twilight may make it tricky to see, NASA says.
The Comet Pan-STARRS will be 28 million miles (45 million kilometers) from the surface of the sun when it swings around the star today, and should be bright enough to see without the aid of telescopes or binoculars, weather permitting. But the comet is also appearing low on the western horizon at sunset so some planning is needed to spot the celestial wanderer with the naked eye tonight.
"Look too early and the sky will be too bright," said Rachel Stevenson, a NASA Postdoctoral Fellow at the agency's Jet Propulsion Laboratory in Pasadena, Calif. "Look too late, the comet will be too low and obstructed by the horizon. This comet has a relatively small window."
A good time to look is about 40 minutes after sunset. The comet may appear as a sort of exclamation point in the evening sky, with the point being the comet itself and its diffuse tail stretching nearly straight up from the horizon, JPL officials added. [How to see the comet]
Comet Pan-STARRS, officially known as comet C/2011 L4 Pan-STARRS, was discovered in June 2011 by astronomers using the Panoramic Survey Telescope and Rapid Response System (or PAN-STARRS), a telescope atop the Haleakala volcano in Hawaii. The comet takes more than 100 million years to orbit the sun and appears to come from the Oort cloud, a vast halo of comets and icy objects at the outer edge of the solar system.
While the comet is making its closest pass by the sun tonight, the best views of the object are still to come. NASA scientists said the comet's proximity to the sun may make it too difficult to spot tonight, but that will change over the next few days.
"As it continues its nightly trek across the sky, the comet may get lost in the sun's glare but should return and be visible to the naked eye by March 12," JPL officials explained. "As time marches on in the month of March, the comet will begin to fade away slowly, becoming difficult to view (even with binoculars or small telescopes) by month's end."
And there is another reason to look for comet Pan-STARRS later this week. On Tuesday (March 12), the moon rises into the cosmic display.
"The comet will be joined in the western sky after dark by the slender crescent moon on March 12, 13, and 14," the editors of StarDate Magazine, a stargazing publication of the McDonald Observatory at the University of Texas. "Good naked-eye views of the comet should continue for several nights, with the comet remaining visible through binoculars into April."
Comet Pan-STARRS is one of three comets capturing the attention of stargazers this year. The Comet Lemmon C/2012 F6 is currently visible to observers in the Southern Hemisphere and at times was in the night sky at the same time, allowing stargazers to capture rare photos of two comets in the sky together.
Meanwhile, the Comet ISON is making its way into the inner solar system and could put on a spectacular cosmic display later this year. Officially designated C/2012 S1 (ISON), Comet ISON was discovered in September 2012 by Russian amateur astronomers Vitali Nevski and Artyom Novichonok using a remotely operated International Scientific Optical Network (ISON) telescope.
Some astronomers have billed Comet ISON as a potential "comet of the century" since it could be brighter than the full moon in daylight when it makes its closest approach to the sun on Nov. 28. At that time, Comet ISON will be much closer to the sun than Comet Pan-STARRS is now. ISON will approach within 800,000 miles (1.2 million km) of the star, making it a true sungrazing comet.
Editor's note: If you snap an amazing photo of Comet Pan-STARRS, or any other celestial object, and you'd like to share it for a possible story or image gallery, please send images and comments, including location information, to managing editor Tariq Malik at firstname.lastname@example.com.
Email Tariq Malik at email@example.com or follow him @tariqjmalik and Google+.Follow us @Spacedotcom, Facebook and Google+. Original article on SPACE.com.

subset: commoncrawl


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Friday, May 06, 2005
Black and White Angel Food Cake
For the cake
1 cup cake flour
1 1/2 cups granulated sugar, divided
1/2 teaspoon cream of tartar
1/4 teaspoon salt
12 large egg whites
1 teaspoon fresh lemon juice
1/2 teaspoon vanilla extract
3 tablespoons Dutch-process cocoa powder
For the glaze
1 1/2 cups confectioners' sugar
2 tablespoons cream cheese, softened
1-3 tablespoon milk, divided
1 teaspoon vanilla extract
1 teaspoon Dutch-process cocoa powder
To make the cake
Preheat oven to 325
In a medium bowl, whisk together flour and 3/4 cup granulated sugar.
In a large mixing bowl, add cream of tartar, salt and egg whites. Beat until foamy. Slowly add the remaining 3/4 cup granulated sugar, 1 tablespoon at a time, beating until stiff peaks form. Mix in juice and 1/2 teaspoon vanilla. Using 1/4 cupfuls at a time, sift flour mixture over the stiff egg whites - gently folding the flour in after each addition.
Scoop one half of the batter into an ungreased 10" tube pan. Use a knife to cut through the batter to break any air bubbles. Sift 3 tablespoons cocoa powder into the remaining batter and gently fold in. Evenly spoon this batter over the top of the vanilla batter. Use a knife to cut through just the chocolate batter to break any air bubbles.
Bake until the cake springs back when lightly touched - about 55 minutes. Remove from the oven and invert the pan - let cool completely. To remove the cake, use a very thin and flexible spatula to loosen the cake from the sides the the center tube. Invert cake to a plate.
To make the glaze
In a medium mixing bowl, beat together confectioners' sugar, cream cheese, 1 tablespoon milk, and 1 teaspoon vanilla until smooth - add enough of the remaining milk to make the glaze thin enough to drizzle, you do want it fairly thick though. Divide batter in half - and add 1 teaspoon cocoa to one part - stir well to combine. Drizzle lines of each glaze over the cake - refrigerate 5 minutes to set the glaze before cutting.
Just found the recipe? Click here to see where we talked about it!
9 comments:
- Anonymous4/03/2007 03:28:00 PM
Beautiful cake Joe! It looks like CL came to your house and took the cover shot! Gorgeous!ReplyDelete
Oh my gosh, how did it come out looking exactly like in the magazine?! I am so impressed, I am beyond words.ReplyDelete
Laurie and Lauren - Thank you! It did take some time, but we really liked the results!ReplyDelete
- Anonymous4/09/2007 03:01:00 PM
Whoa, good job! I tried making this same cake, and it didn't turn out anything like the cake on the magazine! So you just used an extra tablespoon of cocoa powder, hm?ReplyDelete
Ami - Yes, I believe that is the only change that I made!ReplyDelete
- Anonymous5/21/2007 06:44:00 PM
Hi Joe!!ReplyDelete
This is a nice recipe! Can I make it without the cream of tartar? Thats the only thing I dont have right now!
Nisha - you could try, but it helps to stabilize the egg whites as they whip up.ReplyDelete
- Anonymous10/10/2010 05:43:00 PM
My Angel "Fail" cake looked nothing like yours. Mine did not rise and tasted like rubbery eggs.ReplyDelete
I followed your directions step by step. Where did I go wrong?
Anon - several things could have gone wrong, but I'll guess that either the egg whites were not beaten enough/beaten too much. Perhaps the flour was too aggressively mixed in and the whites lost their volume?ReplyDelete


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Wednesday, June 15, 2005
Rhubarb-Cardamom Cake
So, I ended up with quite a big batch of rhubarb after visiting Per's parents, and I wanted to do something new. Rhubarb pairs well with many things - strawberry, lemon, ginger - but I wanted to try something different. And I needed a cake to bring with me to a "fika" with some girls from a cat message board I frequent. I started thinking about some truly marvellous cardamom buns I've had lately (for all you Swedes - Ica Maxi has the best buns ever!) and it struck me that cardamom and rhubarb would probably not be bad at all. I made a fairly normal cardamom cake, and tossed rhubarb with more cardamom and sugar and piled it all at the top. Results? Most excellent! This is very summery, and goes perfect with a tall glass of lemonade.
Rhubarb-Cardamom Cake
For the cake:
100 g butter
600 ml flour
3 tsp baking powder
200 ml sugar
3 tsp cardamom
1 egg
200 ml milk
For the topping:
400 g rhubarb, peeled and cut into 1 cm pieces
50 g sugar
2-3 tsps freshly ground cardamom
Preheat the oven to 175 degrees Centigrade (350F). Melt the butter. Stir together the dry ingredients, add the egg and the milk, and stir well. Add the butter, and stir again. This will be more of a dough than a batter. Pour into a 24-cm lined springpan.
Toss the rhubarb with the sugar and cardamom, and add the pieces to the cake pan. Make sure to cover the top of the cake. Bake in the oven for 45-50 minutes. It will rise quite a bit, so don't use a smaller pan unless you augment the quantities.
6 comments:
- Nic said...
Wow, that looks good, Anne. I bet the girls all loved it!
- June 15, 2005 2:01 PM
- obachan said...
Hi Anne,
First time commenting here. Your rhubarb-cardamon cake looks so nice! Right now I'm experimenting growing rhubarb in a hot and humid area in Japan, but it does not look very successful. If I can somehow get enough rhubarb for baking, I definitely want to give your cake a try. I might be able to get enough for baking a few small cupcakes…
- June 16, 2005 3:51 AM
- Niki said...
That looks wonderful. I'm thinking of making a rhubarb crumble this weekend - it's going to be cold and rainy.
Cardamom is a very popular flavour in Scandanavia, isn't it?
- June 16, 2005 4:14 AM
- Niki said...
Obachan - there's a recent (May 11) recipe for Rhubarb Ginger muffins on Maki's site, 'I was just really very hungry' that you could make with a small portion of rhubarb. :-)
- June 16, 2005 4:19 AM
- Anne said...
Obachan - I hope it works out! Rhubarb is a wonderful.. ehm.. fruit? Vegetable? What *is* it, really? I have no idea. Anyway, I hope it will grow for you!
Nic - they sure did! And so did I.. sigh, I wonder if I should make another one...
Niki - yeah, it is popular here, but it's also considered a bit old-fashioned. Which is in itself, popular. :)
- June 16, 2005 7:14 AM
- obachan said...
Oh, thank you, Niki and Anne!
I'll probably give Maki's version sometime soon before my rhubarb dies in the summer heat :)
- June 17, 2005 3:54 AM


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Folder Size 220.127.116.11 is now fully compatible with the Windows 8 operating system. The new release has also improved memory management for both 32 and 64 bit operating systems and can now utilize up to 3 Gb of memory on 32 bit operating systems and 4 gb on 64 bit.
Read here how to enable 4GT (4-Gigabyte Tuning Windows) on x86 systems: https://msdn.microsoft.com/en-us/library/windows/desktop/bb613473%28v=vs.85%29.aspx.
Even though the application is extremely optimized, just listing the names of millions of files and folders requires a lot of memory. The application can now handle larger than 100 TB drives easily. If you are not interested in the file details a new option "Do not list files" is available in the settings. Using the option will dramatically reduce the memory usage and also improve scan performance.
The new mixed "Larges files and folders" report will help you to easily visualize both folder and files sizes in a combined report.
The count of the selected files and folders is now displayed in the status bar. If no selection is active the count of the files and folders in the currently viewed folder will be displayed.
An annoying bug that displayed the message "There is no default printer currently selected" on every start-up on configurations without printer is now corrected.
The installer now includes an option whether to create or not the 'Scan with Folder Size' context menu.
There are also some small bug fixes applied to the new version. You can read the complete list of all the new features and changes in Folder Size 18.104.22.168 here.
Do you have suggestions or do you miss a feature?
Drop us a line in the comments!
We will be glad to hear your suggestions and implement them if possible.
This article also relates to: Directory Size Windows 8, Disk Size, Drive Size, Folder Size, Folder Size Windows 8, Folder Sizes, Size Of Folder Windows 8, Storage Size, Windows 8 Directory Size, Windows 8 Folder Size, Windows 8 Folder Sizes,


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Delivered: 5 May, 1920
First Published: Pravda, May 2, 1920; Published according to the newspaper text
Source: Lenin's Collected Works, 4th English Edition, Progress Publishers, Moscow, 1965, Volume 31, pages 127-128
Translated: Julius Katzer
Transcription\HTML Markup: David Walters & R. Cymbala
Copyleft: V. I. Lenin Internet Archive (www.marx.org) 2002. Permission is granted to copy and/or distribute this document under the terms of the GNU Free Documentation License
Comrades: You know that, instigated by the Entente, the Polish landowners and capitalists have forced a new war on us. Remember, comrades, that we have no quarrel with the Polish peasants and workers; we have recognised Poland's independence and the Polish People's Republic, and shall continue to do so. We have proposed peace to Poland on the basis of the integrity of her frontiers, although these frontiers extend far beyond the purely Polish population. We have agreed to make all concessions, which is something each of you should remember at the front. Let your attitude to the Poles there prove that you are soldiers of a workers' and peasants' republic, that you are coming to them, not as aggressors but as liberators. Now that, despite our efforts, the Polish magnates have concluded an alliance with Petlyura, launched an offensive, are approaching Kiev, and are spreading rumours in the foreign press that they have already captured Kiev—which is the sheerest fabrication since only yesterday I was talking on the direct line with F. Kon, who is in Kiev—we say: Comrades, we have been able to repel a more terrible enemy; we have been able to defeat our own landowners and capitalists, and we shall defeat the Polish landowners and capitalists too! All of us here today should pledge ourselves, give a solemn promise, that we shall stand as one man so as not to allow a victory of the Polish magnates and capitalists. Long live the peasants and workers of a free independent Polish Republic! Down with the Polish magnates, landowners and capitalists! Long live our Red Workers' and Peasants' Army! (The mighty strains of the "Internationale" and cries of "Hurrah" drown Comrade Lenin's final words.)
[1] This speech was made by V. I. Lenin on May 5, 1920, in Teatralnaya Square (now Sverdlov Square), whore a parade of the Moscow garrison troops took place. Petrograd Communists leaving for the Polish front were also present at the parade.—Editor.


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People are snapping up new desktop and laptop PCs long before the launch of Windows 7, a sign of strong demand in the market, analysts say.
Demand for PCs improved in July and August, which is "something special, because the expectation was that many people would delay purchases until after Windows 7 came out in October," said Manish Nigam, head of technology research in Asia for Credit Suisse, at a technology conference in Taipei.
Consumers often wait until after the launch of a major new operating system to buy a new PC for fear of having to pay for the upgrade and to avoid the hassle of loading the new software themselves. This time, strong marketing for free or discounted Windows 7 upgrades for new PC buyers ahead of the official launch of the OS on Oct. 22 appears to have worked.
There were also fears the global recession might continue to affect PC demand.
PC shipment growth declined for six straight months, from the beginning of the fourth quarter of last year through the end of the first quarter of this year, iSuppli said in a report last week, as the global financial crisis slammed world markets. Sequential growth returned in the second quarter and will continue for the rest of this year as the global economy continues to recover and Windows 7 launches, the market researcher said.
The advertising blitz for Windows 7 "will be a major positive for the PC industry," iSuppli said.
Hype for the new OS, which won solid reviews from many people who tested it, and lower prices for PCs are already drawing buyers.
PC shipments in August beat expectations at investment bank Merrill Lynch by three per cent, as laptop PC demand picked up in Europe and sales remained brisk in China, the bank said in a report on Tuesday.
The investment bank remains positive about the PC sector due to strong sales by Taiwanese manufacturers and healthy inventory levels. Taiwanese companies build a large number of the world's PC components and own most of the PC assembly factories in China.
Business has been so strong in recent months that shortages of a number of components have become troublesome, including LCD screens, laptop batteries and chips such as DDR3 (double data rate, third generation) DRAM.
Indeed, Converge, a chip and component distributor, says shortages have also emerged for a number of key microprocessors. The rising demand suggests the peak season for PC manufacturing has arrived and it appears healthy, Converge said in its monthly newsletter. The company warned that the shortages will increase prices.
Increased costs for PC vendors may not translate into higher prices for consumers, however. The global economy remains weak, and companies continue to offer deals to entice people to buy new desktops and laptops.
The value of global PC shipments dropped 19.1 percent in the second quarter, market researcher IDC said on Wednesday, although the number of PCs shipped declined just 2.4 percent. The researcher attributed the fall to people favoring low-cost devices such as netbooks.
The big question mark for the PC industry is when corporations, which account for nearly 60 per cent of PC shipments, will start replacing aging fleets of computers.
Executives in charge of replacing PCs are more finicky about major OS upgrades than consumers. Decisions they make about new software will affect thousands of computers that they have to maintain. Many are also mindful of how unpopular Microsoft's last OS, Windows Vista, was. The OS launched in early 2007 to great fanfare that quickly turned to disappointment. Customers complained about a number of issues, from clunky performance to missing hardware drivers. Some people even opted to downgrade back to Windows XP.
The problems Vista faced make the transition to Windows 7 potentially slower among corporate users. Analysts expect them to wait until Windows 7 has been on the market for at least several months and Service Pack 1 has been published before adopting the new OS. That means PC purchases by corporations probably won't begin until the middle of next year.
Credit Suisse's Nigam believes U.S. corporations may lead the rebound in PC buying next year, noting capital spending hit its lowest level in years at the depths of the financial crisis, even worse than after the dotcom bust.
The investment bank forecasts a 12 percent increase in corporate PC purchases next year based on surveys with corporate IT managers. Such an increase would likely make PC vendors happy, but it could hurt consumers through potentially higher PC prices, considering the shortages already hitting some PC parts.


text:
Last night, Capcom revealed the expected: Resident Evil 6. Today in Tokyo, Capcom followed up the debut trailer with an event to showcase Resident Evil.
According to game developer and Twitter user Cvxfreak, Capcom said that it was aiming for the highest quality possible with Resident Evil 6. The game takes protagonists Leon Kennedy and Chris Redfield from the U.S. to "A Certain City in China" to stop a deadly virus.
Besides Leon and Chris, there is another male protagonist, but that character's name is currently secret. The female government agent who is Leon's partner is Helena Harper, Cvxfreak tweeted.
In the trailer, there is a nasty, mutating and regenerating enemy with bulbous sores called "Javo".
The game's gameplay is centered on fear, excitement, and amazement, and players, Cvxfreak tweeted, have a wide array of moves at their disposal, as evident by the beatdown Leon unleashes in the trailer. What's also evident is the sheer size of the game. Yoshiaki Hirayabashi, the game's producer, said Resident Evil 6 would have the largest scale of any RE released so far.
As Kotaku previously posted, Resident Evil 6 takes some ten years after the after the Raccoon City incident. It begins with the President of the United States about to reveal the truth behind the incident to the world at large. Unfortunately he instead transforms into something hideous due to a bioterrorism attack, causing his personal friend and bodyguard Leon S. Kennedy to clean up the mess.
In case you missed it, check out the game's debut trailer.
Cvxfreak [Twitter]


text:
Read a version of this story in Arabic.
Story highlights
NEW: The death toll from the storm is now 95, a government agency says
The storm has churned across the southern Philippine island of Mindanao
It has set off a landslide and blown away fragile houses, officials say
The typhoon comes almost a year after a storm killed more than 1,200 people on Mindanao
An intense typhoon has carved across the southern Philippines, destroying buildings, setting off floods and landslides and killing at least 95 people, authorities said Wednesday.
Typhoon Bopha struck the large southern island of Mindanao, which is rarely in the direct path of tropical cyclones, fueling fears that it could be as devastating as a storm that killed more than 1,200 people there almost a year ago.
Bopha, the most powerful typhoon to hit Mindanao in decades, had top winds of 175 kph (110 mph) as it came ashore over the city of Baganga early Tuesday. Millions of people, many of whom live in remote and unprepared communities, were in the storm's path, Philippine authorities and aid groups said.
Watch: iReporter captures Typhoon aftermath in southern Philippines
"It really is getting to be a very, very big typhoon and it's just starting," Richard Gordon, the head of the Philippine Red Cross, said Tuesday.
Trees have been uprooted and fragile houses blown away on Mindanao, Gordon said, adding that the corrugated iron roofs of some buildings were being carried through the air by the wind like "flying machetes."
At least 95 people have been killed so far as a result of the storm, the National Disaster Risk Reduction and Management Council said Wednesday.
The typhoon has affected more than 213,000 people, demolished houses and stranded people in two Mindanao regions and parts of the Visayas region, according to the disaster agency. More than 179,000 people are in evacuation centers, it said.
A landslide in eastern Mindanao blocked a national highway, the news agency reported, leavening hundreds of people in buses, vans and cars stuck on the road.
iReport: Plight of typhoon evacuees
Maintenance workers were using heavy equipment to clear the mud and rocks, said Dennis Flores, a spokesperson for the Department of Public Works and Highways cited by the news agency.
The tightly packed but fierce typhoon churned west northwest across the island, weakening slightly as it went, the Philippine Atmospheric, Geophysical and Astronomical Services Administration said.
By Wednesday morning, the center of the storm was approaching the outlying western island of Palawan. But it continued to soak a wide area with heavy rain, raising the risk of mudslides and flash floods elsewhere.
The storm, dubbed "Pablo" in the Philippines, had blown up into a super typhoon at one point Monday as it moved over the ocean, with sustained winds greater than 240 kph – the equivalent of a Category 5 hurricane in the Atlantic Ocean, the Joint Typhoon Warning Center reported.
That wind speed is two and a half times the top winds of Severe Tropical Storm Washi, known in the Philippines as Sendong, whose heavy rains swept away entire villages in the same region in December 2011.
"Many emotional people in (Mindanao) trying to prepare for Pablo with Sendong fresh in their minds," Carin van der Hor, the Philippines director for the children's charity Plan International, wrote Monday on Twitter.
But local authorities have done a good job of relocating people out of vulnerable areas and preparing evacuation centers, said Gordon of the Red Cross.
Washi, on the other hand, caught many residents off guard. It was a weaker storm, but its torrential rain triggered landslides and flash floods in the middle of the night, when many people were sleeping. More than 1,200 people died and hundreds of thousands were left homeless, prompting a humanitarian crisis.
Ahead of Bopha's arrival on Tuesday, government agencies relocated more than 50,000 people to evacuation centers. They also moved millions of dollars worth of relief supplies into position for quick delivery to storm-hit regions and put emergency crews, the military and hospitals on standby.
School classes were suspended in many cities, and dozens of flights were canceled, according to the national disaster agency. Nearly 5,000 travelers were left stranded at ports across the country as of Wednesday because of disruption to ferry services.
Palau, a tiny island nation roughly 1,000 kilometers (600 miles) east of Mindanao, had a close shave with Bopha earlier in the week as the typhoon churned past, catching some outlying parts of the archipelago.
"It was headed right toward Palau," said Derek Williams, a meteorologist for the U.S. National Weather Service in Guam. But at the last minute, "it just turned to the west and fortunately went south of them," he said.
"I really think they escaped the brunt of the storm," Williams said in an interview with the Australian Broadcasting Corporation, noting that Palau doesn't usually get hit by strong typhoons.
Bopha nonetheless brought down a lot of trees and caused widespread power outages in Palau, according to Williams.
"The fast movement of the system really prevented a lot of flooding," he said. "I think probably only a few inches of rain fell, so that's certainly good news, because Palau itself is susceptible to mudslides."
CNN's Sarita Harilela and Elizabeth Joseph, Michael Pearson and Neda Farshbaf contributed to this report.


text:
Acts of the Apostles
This book, as stated in its opening words, is the second of a two-part work written to Theophilus. The first part is known to us as the book of Luke. The early part of Acts records some of the major missionary activities of the Twelve Apostles under the direction of Peter during the time immediately following the death and resurrection of Jesus Christ. The last half of the book outlines some of the travels and missionary work of Paul. It is evident that the book of Acts is not intended to be a comprehensive history of the early Church but is mainly a recitation of the early missionary efforts and the important opening of missionary activity to peoples other than the Jews. A brief outline of the book is foreshadowed by Jesus' words in Acts 1:8, "Ye shall be witnesses unto me both in Jerusalem (Acts 1–5), and in all Judea, and in Samaria (Acts 6–9), and unto the uttermost part of the earth (Acts 10–28)."
"In Jerusalem." After an introduction containing an account of the Ascension (1:10–14) and the calling of Matthias to the Quorum of the Twelve (1:15–26), missionary work in Jerusalem goes forth with the outpouring of the Spirit on the day of Pentecost (2:1–13) and with Peter's bold declaration of the divinity of Jesus Christ and His literal bodily resurrection from the grave. In consequence of Peter's preaching on this occasion three thousand persons were added to the Church by baptism (2:37–47).
We are shown how on two critical occasions the Sanhedrin refused to accept the testimony of the Brethren. The first occasion arose out of the arrest of Peter and John for preaching in the temple after healing the lame man (3:1–4:4). The second occasion was in consequence of the large number of converts coming into the Church (Acts 5) and resulted in a formal rejection of the apostolic doctrines (5:17–42).
"In all Judea and in Samaria." This is recorded in three stages. First we are told of the preaching of Stephen and that his martyrdom caused a dispersion of Church members throughout Judea and Samaria (6:8–8:2). Specific mention is made that one of the seven chosen to help with the affairs of the Church was a proselyte from Antioch. This designation means that he was probably of gentile lineage and was converted to Judaism before he joined the Christian Church. Then is recorded the work of Philip and of Peter and John in preaching the gospel in Samaria (a people who are not Jews, although partly of Israelite origin) (8:4–40) and also the baptism of the Ethiopian eunuch (8:26–40) (probably a non-Israelite by lineage but previously converted to Judaism before being baptized by Philip). All of this shows the gradual outreach of the Church: first to Jews, then to non-Jewish Israelites, and then to non-Israelite persons previously converted to Judaism. Then is given an account of the conversion of Saul of Tarsus and his early preaching, first at Damascus and then in Jerusalem (9:1–31). The coming of Saul into the Church presages the remaining portion of the book of Acts.
"Unto the uttermost part of the earth." This portion also falls into three phases. The first (9:32–11:26) contains the opening of the door for the worldwide extension of the gospel. This was done by the baptism of Cornelius (10:1–11:18) at Caesarea and also the establishment of the Church in Antioch (11:19–26). Both of these events were among non-Israelite people. Cornelius' entry into the Church inaugurates a new era because he is the first non-Israelite of whom we have record who entered into the Church without first having been converted to Judaism. The second phase (11:27–15:35) describes the continued activity of the Church at Antioch (consisting primarily of gentile members) and of the work there of Barnabas and Saul. The third phase (15:36–28:31) contains an account of the missionary activity of Paul (Saul), being an account of his travels through Asia Minor and Europe, by which he introduced the gospel of Jesus Christ to Jew and Gentile, and especially to the Gentile.
Although the book of Acts tells us of the preaching of only a few of the original members of the Twelve (namely Peter, James, and John), we conclude that the other Apostles were also actively bearing testimony of Jesus Christ and establishing the Church in whatever lands they could reach. Perhaps they visited in the areas east, north, and south of Palestine. People from such areas are mentioned as having been present on the day of Pentecost (Medes, Elamites, Mesopotamia, Cappadocia, Egypt, and Arabia, Acts 2:9–11), and it is probable that the gospel was first carried into these lands by these people returning from the Feast of Pentecost in Jerusalem and was formally established by the leaders of the Church in the ensuing years.


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Friday, January 23, 2009
Dwimmermount: The Product
There are a couple of reasons why I'm thinking of doing this. Firstly, I've created some nifty house rules, monsters, spells, magic items, and other such things that I'd like to share in a format more "solid" than this blog. Second, I have some ideas I'd like to try out regarding the "ideal" way to present supplementary material for RPGs. While I take a lot of inspiration from the "grab bag" approach used in the original OD&D supplements, it's not quite the approach I want to take. Likewise, I regard most modern supplements to be unhappily systematic in their approach, favoring clarity and comprehensiveness over suggestiveness and brevity.
(Much as I love the nostalgia value of seeing new books done in the style of OD&D's little brown books, that's not a style I have any interest in adopting as my own either.)
As I conceive it now, this theoretical product would consist of two parts. The first would have all the "goodies" that are the staple of such supplements, with an emphasis not so much on new rules as one new ideas/examples that work with the existing rules. I'm actually coming round to the notion that, except in the case of entirely new systems without any coverage in the core rules -- such as mass combat in the case of S&W, for example -- there's no good reason to include new rules that could just as easily be created through play on an ad hoc basis.
The second part would be campaign-oriented stuff. I'd give some slices of what my Dwimmermount campaign is like without going overboard. So, there might be a map of the starting campaign area, used as a literal example of how to create one's own. Likewise, I'm thinking I might well include several levels of Dwimmermount's dungeons itself, presented in abbreviated form thanks to the wonderful one-page templates that Sham, Chgowiz, and Mike originated and developed. The more I interact with people, the more I realize that, even among old schoolers of long years, the megadungeon and sandbox concepts aren't well understood. What's needed is more than mere philosophizing about the finer points of these foundational concepts and more practical examples and advice on how to use them to good effect.
Like a lot of my theoretical projects, this one may never come to pass, but I hope it does. The campaign is going very well, despite the obstacles and I feel like I've gleaned a lot of useful insights through refereeing it. Plus, in all honesty: there's never been a better time to produce and publish your own old school books and I want to get in on that action.
23 comments:
I certainly would love to see such a product. :)ReplyDelete
It seems a pity, though, that you wouldn't officially note its compatibility with S&W simply because you don't want to include ascending ACs in brackets in addition to the standard descending ACs. The more S&W stuff available, the more people will notice it, and hopefully try it. (Okay, okay, I'll stop bothering your about the whole AC thing now.;) )
Dwimmermount and AC stuff aside, I've been enjoying your blog. Good stuff!
I'll second that...ReplyDelete
The family is having a hoot in the Ruined Monastery, and after reading everything you've churned out regarding Dwimmermount I can honestly say it's something I'd be eminently interested in reading / playing.
I should mention, James, that I ran your "Ruined Monastery" adventure last summer (with the B/X D&D rules), and had a great time with it!ReplyDelete
Heh - I was going to say what Akrasia did - S&W doesn't force anyone to use ascending AC - all that the license requires is a second AC number in brackets next to the regular AC number. Which makes the "product" much more attractive to people who might use it with C&C or with BFRPG.ReplyDelete
I would LOVE a Dwimmermount supplement! I hope you are able to make it happen. :)ReplyDelete
As far as the AC thing, I agree with Akrasia and Mike, it's such a small detail. Why not just throw it in there? Isn't the point of old school gaming to leave it open so people can infuse their particular tastes?
- AnonymousJanuary 23, 2009 at 2:50 PM
I'd LOVE to see Dwimmermount as a product. Please, please, please do it. :)ReplyDelete
Link to the "wonderful one-page templates"?ReplyDelete
>should mention, James, that I ran your "Ruined Monastery<ReplyDelete
Yo James, where can I find it? I may be needing an alternate adventure for my planned game next week.
Even if I never ran anything set in Dwimmermount, I would like to have hard copy in hand just for entertaining reading. So go for it!
In true New School form.. I'd download it just to read it.ReplyDelete
I would most probably buy this, as well. Yum!ReplyDelete
@Delta: Chgowitz has links to the templates here:ReplyDelete
Or more to taraget here:ReplyDelete
It seems a pity, though, that you wouldn't officially note its compatibility with S&W simply because you don't want to include ascending ACsReplyDelete
The thing is I use AC much more "straight" than most people. I don't allow Dex bonuses to AC. I subtract magical armor bonuses from an opponent's attack roll. I also use a weapon vs. AC table. All these factors would make Ascending AC somewhat incoherent (or at least infelicitous) in the context of the Dwimmermount supplement. And I just find it esthetically displeasing.
I realize these will seem like unnecessary quibbles to a lot of people and that's fine. One of the great things about old school gaming is how tolerant it is of eccentricities!
Which makes the "product" much more attractive to people who might use it with C&C or with BFRPG.ReplyDelete
Oh yes, I fully understand and appreciate that point, but I have a reputation of being a narrow-minded dogmatist to uphold! :)
Why not just throw it in there? Isn't the point of old school gaming to leave it open so people can infuse their particular tastes?ReplyDelete
Sure, but that same openness applies to me as well and I just don't like Ascending AC.
Sounds like a great idea, leading by example. (I say, looking sadly at piles of unfinished projects.)ReplyDelete
"examples that work with the existing rules", "example of how to create one's own (campaign)"ReplyDelete
That's the spirit. Naturally you emphasize 'old school' and OD&D but keep in mind there are people like me who consider 1ed AD&D core but have respect for the traditions or the First Way. The old school caliber of dungeon exploration, as with anything so well argued and persuasive, might be appropriated by keen-eyed AD&D DMs for underground adventures.
Perhaps your audience is wider than you think.
I'd certainly check it out.ReplyDelete
I still don't understand why you have issues with ascending AC, though. I mean, I s'pose it's traditional, but so are lots of other things that work just fine a different way.
Perhaps your audience is wider than you think.ReplyDelete
I certainly hope so! I have, however, learned the virtue of low expectations.
"The thing is I use AC much more "straight" than most people. I don't allow Dex bonuses to AC. I subtract magical armor bonuses from an opponent's attack roll. I also use a weapon vs. AC table. All these factors would make Ascending AC somewhat incoherent "ReplyDelete
'Incoherent'? Why? I don't see any 'incoherence' in doing all of those things with an ascending AC.
But even if the ascending AC is incoherent for some reason for your purposes, I still don't understand your opposition to including it, since the descending AC is included as well (and is listed first). It seems a pity to not help promote S&W, and help out players who want to use your product with the ascending AC system, especially if doing so does not in any way adversely affect those who prefer the descending system.
OK, I'll stop now ... :)
OK, I'll stop now ... :)ReplyDelete
Feel free to continue; you might just convince me -- though I doubt it.
This is a taste issue, though, like styles of artwork or naming conventions or dozens of other things. I just don't like ascending AC esthetically and find it an unnecessary deviation from the standard D&D AC system, so I'm not going to use it.
Okay, since I'm not actively irritating you with this, here's another try... :PReplyDelete
Obviously, for your own games, there is no reason to use the ascending ACs.
The question is: what would be the benefits and costs of including the ascending ACs -- along with the descending ones, of course -- in a product meant for others to use?
Consider the benefits of including the ascending ACs:
1. Increases the visibility of S&W by putting another 'official' S&W product out on the market.
2. Increases the market for your product by tying it to S&W.
3. Helps players who use the ascending AC system use your product in their games.
What are the costs?
The only one is that you personally find it aesthetically unappealing to include the ascending ACs in square brackets after the descending ACs.
Okay, fair enough. But, of course, when running your own games, you don't need to use the version that is being made available to the public. You own the original document! If simply ignoring the number is too irritating, delete them from the document.
In short, there seems to be no real benefit to not including the ascending AC. It seems like a strange reason to deliberately forgo tying your product to S&W.
Personally, I vastly prefer the ascending AC system. I like not having to consult 'to hit' charts or use THAC0. I have no idea why D&D didn't always use this system, given how intuitive it is compared to the descending system (it certainly is much more intuitive for new players, IME). However, my aesthetic and 'playability' reason for preferring the ascending AC system doesn't seem like a reason to not include the descending AC stats for the things that I write (and have written) for S&W.
Would definitely look through such a product; publish it and people will read it.ReplyDelete
The AC thing: Aesthetically, I like descending AC, but practically, I like ascending AC. one of the things i like about swords and wizardry is that it gives both!


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Maputo Bay
Maputo Bay, formerly Delagoa Bay (dĕl´əgō´ə), inlet of the Indian Ocean, c.55 mi (90 km) long and 20 mi (30 km) wide, S Mozambique, SE Africa; Maputo, the capital and chief port of Mozambique, is on the bay. Maputo Bay is a large deepwater harbor, with numerous quays to handle oceangoing vessels; railroads lead into the interior. The first Westerner to visit (1502) the bay was António do Campo, one of Vasco da Gama's captains; the area was explored in 1544 by Lourenço Marques, the Portuguese trader. In the 1700s, Dutch and Austrian trading companies tried to establish posts on the bay; both were driven out by malaria and the Portuguese. In 1787, Portugal built a fort there, around which the town of Lourenço Marques (Maputo) grew. In the mid-1800s, Portugal's claim to the area was challenged by Great Britain and by the Transvaal when it was realized that the bay provided a major access route to the Kimberley diamond mines. The Transvaal recognized Portugal's sovereignty in 1869, and in 1875 France, acting as arbiter, awarded the area to Portugal.


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|Key Information
|Exeter, England
|Famous Courses
|Business, IT, Economics
|International Fees
The University of Exeter was founded in 1955, although its complete history dates back as far as 1900. At present around 20,000 students from over 140 countries study at the University's three campuses in the South West of England. Despite being relatively young, Exeter is a member of the UK's elite Russell Group and is in the top 1% of universities worldwide.
Six academic colleges offer study opportunities at undergraduate, masters and research level in a wide range of subjects across science, humanities and social sciences. The University of Exeter has a longstanding international approach, with many courses offering the opportunity to study abroad. All students are offered foreign language tuition, either as part of their chosen degree or as a separate evening class. Graduate prospects are further improved by a focus on career management skills and the possibility of work placements and internships as part of the degree programme.
The International Student Support Office can help students with issues such as visas, bank accounts and settling in at the beginning of term. The office also publishes Your International News every month, which details the various international events run throughout the year. These include trips to various cities and nearby attractions as well as cultural festivals and celebrations.
All students are allocated a personal tutor, a member of staff from the same academic school, who is available to discuss problems or academic progress. The University was named best in UK for international student satisfaction by StudyPortals November 2014 and is also 1st in the Russell Group for student satisfaction.
INTO University of Exeter run both pre-sessional and in-sessional English lessons for students, which cover subject-specific as well as general academic and social English.
27 subjects were ranked in the top 10 in both The Times and Guardian University Guide and 98% of Exeter research is of international quality according to the REF 2014.
Accommodation is guaranteed for all new unaccompanied international students who accept an offer and apply for accommodation by the deadline. There is a wide range of catered and self-catered accommodation, with studio flats and shared houses available. All are within 20 minutes' walk of the nearest campus. Self-catered accommodation is generally arranged in flats of three to twelve people with a shared kitchen and communal area. Private rented accommodation is available through landlords or private halls of residence.
The University's three campuses in the South West of England offer a safe, high quality environment for both study and living. Academic, social and sports facilities are conveniently located within easy walking distance of one another and the local city facilities.
The University of Exeter's main Streatham Campus is regarded as one of the most beautiful parkland campuses in the UK. Overlooking the Roman city of Exeter which is now the regional capital, it features beautiful architecture and excellent retail and leisure facilities. The St Luke's campus where Sport Science, Medicine and Education students study is also located here. Exeter is the 6th safest place to live in the UK and the 4th top place to live in the UK for recreation (Rightmove 2013). The city's transport hubs include Exeter St Davids railway station, connecting to London in 2 hours, the M5 motorway and Exeter International Airport connecting the city both nationally and internationally.
The Penryn Campus in Cornwall is a unique campus that brings the heart of the University of Exeter to an environment unrivalled in the UK. Set in a recognised Area of Outstanding Natural Beauty, and offering immediate access to the fantastic South West coastline, it boasts the very latest in teaching facilities, plus a friendly atmosphere and innovative programmes, which combine to offer a great student experience.
94% of international students reported feeling safe and secure at the University, with 95.5 per cent agreeing that the location was a 'good place to be' (International Student Barometer Autumn 2013).
SI-UK's service is fast, reliable and efficient. Their consultants are specialists, working closely with all UK universities and, through my consultants' advice and application assistance, I was able to receive offers from my favoured universities.
Carla Termini King's College London, Accounting and Finance


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After earning an art degree from Syracuse University in 1952, Frank Springer served a tour in the U.S. Army. From 1955 to 1960, he was assistant to George Wunder on 'Terry and the Pirates'. As a freelance cartoonist, Springer has drawn a wide variety of action and adventure comic books. However, his most lasting fame was for drawing 'The Adventures of Phoebe Zeit-Geist', written by Michael O'Donoghue and published in Evergreen Review in 1965-66. Sexy cartoon albums were not new in Europe, but 'Phoebe Zeit-Geist' was a sensation in the United States. Also for the Evergreen Review, he made 'Frank Fleet' in 1969-70. Springer passed away in April 2009 at the age of 79.
Brainboy (1963)
He was present at Dell Publications throughout the 1960s, where he drew for comic books like 'Big Valley', 'Brain Boy', 'Charlie Chan', 'Ghost Stories', 'Knights of the Round Table', 'Toka, Jungle King', and many others. From the late 1960s to the late 1980s, he was present as an inker on several titles and as a penciller on 'Dial H for Hero', 'Elongated Man', 'Our Army at War', 'The Shadow' and 'House of Mystery'.
Dracula (1974)
From the late 1960s, he also drew for Marvel, contributing movie adaptations and having regular runs on 'Spider-Man', 'Spider-Woman' and the initial 'The Transformers' miniseries. He additionally did artwork for companies like Seaboard Comics ('The Cougar', 'Luke Malone'), Charlton ('Haunted') and Continuity ('Armor').
Transformers- More than meets the eye #1
He also returned to newspaper comics in the 1970s, working on the syndicated titles 'Rex Morgan, M.D.', 'Incredible Hulk' and 'Virtue of Vera Valiant'. In the 1990s, he worked on the newspaper strip 'The Adventures of Hedley Kase'. He has drawn cartoons and features for the New York Daily News and Muppets Magazine (based on Jim Henson's creations). Between 1971 and 1988, he was a regular contributor to the National Lampoon, using pen names like Francis Hollidge and Bob Monhegan.


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We had a blast kicking off the RadioBDC Coors Light Drafters season at Bretton Woods back in January, and we have the pictures to prove it. We had so much fun, in fact, that we're closing out our season there, too. And we want you to join us.
Join us on Thursday, March 20 at Stadium on State St. in Boston from 5-7 p.m. or Murhpy's in Salem from 10 p.m.-midnight for a chance to score free lift tickets to ski and ride Bretton Woods with us this Saturday. Get all the details here.
Can make it up this Saturday? Don't worry. Bretton Woods has the most open terrain in New Hampshire, and spring skiing there is the best. Click here for conditions and deals!


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Native Plants
Search for native plants by scientific name, common name or family. If you are not sure what you are looking for, try the Combination Search or our Recommended Species lists.
Agave havardiana
Agave havardiana Trel.
Havard's Century Plant, Havard Agave
Agavaceae (Century-Plant Family)
USDA Symbol: agha
USDA Native Status: L48 (N)
From the Image Gallery
Plant CharacteristicsDuration: Perennial
Habit: Subshrub
Leaf Retention: Evergreen
Leaf Complexity: Simple
Leaf Margin: Dentate
Leaf Apex: Acute
Leaf Texture: Leathery
Fruit Type: Capsule
Size Notes: 3' x 3', to 15' when blooming
Bloom InformationBloom Color: Yellow , Green
Bloom Time: Jun , Jul , Aug , Sep
DistributionUSA: TX
Growing ConditionsWater Use: Low
Light Requirement: Sun
Soil Moisture: Dry
Conditions Comments: Rosette of broad fleshy gray-green leaves with toothed margins and stout spine tip. Upon maturity (20 to 40 years), thick candelabra-like flower stalk with large clusters of yellow flowers arises in summer and plant dies thereafter; good landscape accent requiring low water, full sun to light shade in well draining soil; hardy to 15 degrees.
BenefitConspicuous Flowers: yes
Interesting Foliage: yes
Nectar Source: yes
Deer Resistant: Moderate
Mr. Smarty Plants says
Drought-tolerant shrub for privacy screen
November 23, 2007
Is there some kind of drought resistant bush or thorny plant we can rim our property with to stop all the foot traffic through our yard? We don't care if it's pretty, just something thick and/or th...
view the full question and answer
From the National Organizations DirectoryAccording to the species list provided by Affiliate Organizations, this plant is on display at the following locations:
NPSOT - Austin Chapter - Austin, TX
NPSOT - Williamson County Chapter - Georgetown, TX
Wildflower Center Seed BankLBJWC-MLE-30 Collected 2009-07-02 in Jeff Davis County by Lady Bird Johnson Wildflower Center
BibliographyBibref 995 - Native Landscaping from El Paso to L.A. (2000) Wasowski, S. and A. Wasowski
Search More Titles in Bibliography
From the ArchiveWildflower Newsletter 1990 VOL. 7, NO.2 - Preservation Blooms in Recreated Prairies, New Wildflower Center Prairie Welcome...
Additional resourcesUSDA: Find Agave havardiana in USDA Plants
FNA: Find Agave havardiana in the Flora of North America (if available)
Google: Search Google for Agave havardiana
MetadataRecord Modified: 2010-06-07
Research By: TWC Staff


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OpenMP Technology
The article briefly describes the OpenMP technology.
OpenMP (Open Multi-Processing) is a set of compiler directives, library procedures and environment variables intended for programming multi-threaded applications on multi-processor systems with shared memory (SMP-systems).
The first OpenMP standard was developed in 1997 as an API oriented on writing easy portable multi-threaded applications. At first, it was based on Fortran language but then included C and C++ as well.
OpenMP interface became one of the most popular parallel programming technologies. OpenMP is successfully exploited both in programming of supercomputer systems with many processors and in desktop user systems or, for example, Xbox 360.
OpenMP specification is developed by several large computer and software vendors whose activity is regulated by the non-profit organization "OpenMP Architecture Review Board" (ARB) [1].
OpenMP exploits the parallel execution model called "branching-merging". OpenMP program begins as a single execution thread called the initial thread. When the thread meets a parallel construction, it creates a new group of threads consisting of the initial thread itself and some other threads and becomes the main thread in the group. All the members of the new group (including the main thread) execute the code inside the parallel construction. At the end of the parallel construction, there is an implicit barrier. After the parallel construction is processed, the further execution of the user code is performed only by the main thread. A parallel area may include other parallel areas where each thread of the initial area becomes the main thread of its thread group. The embedded areas may also include areas of a deeper nesting level.
The number of threads in a group performed concurrently can be controlled by several methods. One of them is using the environment variable OMP_NUM_THREADS. Another method is to call the procedure omp_set_num_threads(). One more way is to use the expression num_threads together with parallel directive.
OpenMP and other parallel programming technologies
At present, MPI interface (Message Passing Interface) is considered to be the most flexible, portable and popular interface in parallel programming. But the Message Passing Interface:
- is not too efficient on SMP-systems;
- is relatively difficult to study because it demands thinking in "non-computing" terms.
POSIX-interface for threading (Pthreads) has a wide support (nearly on all UNIX-systems) but due to many reasons it does not suite the practical parallel programming:
- Fortran is not supported;
- its level is too low;
- no support for data concurrency;
- the threading mechanism was originally developed not for the purposes of computing concurrency arrangement.
OpenMP can be viewed as a high-level superstructure over Pthreads (or other similar thread libraries). Let us list the advantages OpenMP provides a developer with.
- Due to the idea of "incremental parallelization", OpenMP is ideal for the developers wishing to quickly parallelize their applications with large parallel loops. A developer does not create a new parallel program but simply adds OpenMP-directives into the text of a serial program.
- OpenMP is a very flexible mechanism providing the developer with great capabilities of controlling a parallel application's behavior.
- OpenMP-program is supposed to be used as a serial one on a single-processor platform, i.e. you do not need to support both the serial and parallel versions. OpenMP-directives are simply ignored by the serial compiler and to call the OpenMP-procedures you may place stubs whose texts are given in the specifications.
- One of OpenMP's advantages, as its developers point out, is support of the so called "orphan" directives, i.e. work synchronization and distribution directives do not necessarily need to be included directly into the lexical context of a parallel area.
OpenMP and toolkit
At present, OpenMP technology is supported by most C/C++ compilers. Yet, it is not so good with the tools of testing parallel OpenMP programs. Although analysis tools and tools for testing and optimizing parallel programs have existed for a long time, they were not too popular in the sphere of applied software development until recently. That is why they are often less convenient than other development tools.
The fullest support of parallel OpenMP-program development is provided by the package Intel Parallel Studio. It includes a tool of preliminary code analysis for detecting code fragments that can be potentially parallelized. There is a compiler with OpenMP support providing good optimization. There is also a profiler and a dynamic analysis tool for detecting parallel errors.
- OpenMP Architecture Review Board. http://www.openmp.org/
- Joel Yliluoma. Guide into OpenMP: Easy multithreading programming for C++. http://bisqwit.iki.fi/story/howto/openmp/


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'Walter le Loup'.
Born in the Andalusian city Lorca, José-Luis Munuera attended the School of Fine Arts in Granada. He made his debut with 'No Hay Domingos en el Infierno' for the Spanish publisher Lunáticos in 1995, but subsequently focused on working for French publishers like Delcourt and Dargaud. At the Angoulême Comics Festival he met Joann Sfar with whom he began a collaboration on series like 'Les Potamoks' (1996-97) and 'Merlin' (1999-2001), series published by Delcourt. Munuera was additionally working for Bayard Presse, illustrating the 'Sam Trot' feature in J'Aime Lire.
Munuera worked with scriptwriter Jean-David Morvan for the first time in 1999, when they created 'Sir Pyle S. Culape' for Lanfeust Mag by Soleil Productions. Morvan also took over the scriptwriting of 'Merlin' for two more books in 2002 and 2003. Also with Morvan and in cooperation with Philippe Buchet, he created 'Nävis' (Delcourt, 2003-2009), a series that told the youth of the principal character from 'Sillage'. Between 2004 and 2006, Munuera and Morvan created three new albums for the classic Dupuis series 'Spirou et Fantasio' in succession of Tome and Janry.
Apart from Delcourt, Munuera has also worked extensively for Dargaud. In 2000, he had already made a comic adaptation of the Dreamworks film 'The Road to Eldorado' for this publisher. He resumed his work for Dargaud in 2009 when he created the dramatic comic 'Le Signe de la Lune' with Enrique Bonet. It was followed by the funny animal series 'Walter Le Loup', for which Munuera writes the scripts himself, in 2010 and the graphic novels 'Fraternity' (with Juan Díaz Canalès, 2011) and 'Sortileges' (with Jean Dufaux, 2012-2013).
'P'tit Boule et Bill'.
Between 2011 and 2013 he made the drawings for four booklets in the series 'P'tit Boule et Bill' with Laurence Gillot, based on the characters by Jean Roba and Laurent Verron. He returned to Dupuis in 2014 as the writer and artist of the pirate comic 'Les Campbell'. In the 2020s Munuera started adapting literary classics in graphic novel form. His first release was 'Bartleby, The Scrivener', based on Herman Melville's short story of the same name. For 2022, an adaptation of Charles Dickens' 'A Christmas Carol' has been announced.
'Le Signe de la Lune'.


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Nicoletta CeccoliUnder - Art, Illustration, Inspiration
Surrealism, fantasy, magic, strange creatures and a beautiful doll-like character among all these with very distinct innocent facial features. There's definitely much more in Nicoletta Ceccoli's work to make you feel absorbed in a timeless and spaceless world she paints. I came across this brilliant Italian artist's work through Bak Magazine and enthralled since.
Nicoletta Ceccoli, an award winning children's book illustrator, has illustrated over 30 books since 1995 mainly with USA, UK , and Italian publishers. Her clients included among the others Random House, Simon and Shuster, Houghton Mifflin, Mondadori, and Grimm Press.
In 2001 she was awarded the Andersen prize 'Baia Delle Favole' as the best illustrator of the year in Italy. In 2006 she was awarded with a silver medal from the Society of Illustrators of New York. Nicoletta Ceccoli has exhibited her work in group and solos shows across Europe and North America.


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Boeing, Primera Air announce order for 737 MAX 9s
Boeing and Primera Air have announced an order for eight 737 MAX 9 airplanes, valued at more than $950 million at list prices. The agreement also includes purchase rights for four additional 737 MAX 9s and a lease agreement for eight more airplanes from Air Lease Corporation.
May 11, 2017 By Boeing
The 737 MAX 9 will form the backbone of the low-cost airline's future as it seeks to commence flights between Europe and North America. Primera Air plans to use the MAX 9's auxiliary fuel tanks to lower trip costs and maximize the range to accommodate flights connecting Europe to the east coast of the U.S.
"The 737 MAX 9 will allow Primera Air to open up nonstop, long-haul routes from Europe to the U.S. with unmatched economics," said Andri M. Ingolfsson, president, Primera Air. "This aircraft has a lower per-seat cost than the current wide body aircraft servicing the transatlantic and the capabilities of this aircraft type will change the economics of the industry. This will open up fantastic possibilities for growth for Primera Air in the future."
"Primera Air's commitment is a major endorsement of the 737 MAX 9 and its ability to serve new transatlantic markets," said Monty Oliver, vice president, European Sales, Boeing Commercial Airplanes. "The MAX 9 will provide Primera Air unmatched efficiency, range, reliability and operating costs, while continuing to provide a premium on-board experience for its passengers."
Primera Air is an all-Boeing carrier currently operating a fleet of nine Next-Generation 737-700s and 737-800s with flights to more than 70 airports in Europe. Primera Air is part of the Primera Travel Group that operates travel agencies and tour operating companies in Sweden, Denmark, Norway, Finland, Iceland and Estonia.
The 737 MAX family has been designed to offer customers exceptional performance, flexibility and efficiency, with lower per-seat costs and an extended range that will open up new destinations in the single-aisle market. The MAX 8 and 9 will be followed in 2019 by the smaller MAX 7 and higher capacity MAX 200, while studies and customer discussions continue on further growing the family.
The 737 MAX incorporates the latest technology CFM International LEAP-1B engines, Advanced Technology winglets and other improvements to deliver the highest efficiency, reliability and passenger comfort in the single-aisle market.
The 737 MAX is the fastest-selling airplane in Boeing history, accumulating more than 3,700 orders from 87 customers worldwide.
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- Southern Ontario airports unite to increase demand, capacity
- Bombardier Global 7000 FTV3 takes to the skies


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Hand & Foot Game
August 16, 2019 @ 12:30 pm - 4:00 pm
|Recurring Event (See all)
Every Friday
Hand & Foot is a card game for 4-8 players at a table. The object of the game is to get rid of cards from your hand pile and then from your foot pile. The group will help newcomers learn the game. It is important to arrive on time as partners and tables are determined at the beginning. (SG)
Related Events
Fall 2023 Program Guide
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From tries to trees
This post is the last of a series of six relating numbers, vectors, and trees, revolving around the themes of static size-typing and memo tries. We've seen that length-typed vectors form a trie for bounded numbers, and can handily represent numbers as well. We've also seen that n-dimensional vectors themselves have an elegant trie, which is the n-ary composition of the element type's trie functor:
type VTrie n a = Trie a :^ n
where for any functor
f and natural number type
f :^ n ≅ f ∘ ⋯ ∘ f -- (n times)
This final post in the series places this elegant mechanism of n-ary functor composition into a familiar & useful context, namely trees. Again, type-encoded Peano numbers are central. Just as
BNat uses these number types to (statically) bound natural numbers (e.g., for a vector index or a numerical digit), and
Vec uses number types to capture vector length, we'll next use number types to capture tree depth.
- 2011-02-02: Changes thanks to comments from Sebastian Fischer
- Added note about number representations and leading zeros (without size-typing).
- Added pointer to Memoizing polymorphic functions via unmemoization for derivation of
Tree d a ≅ [d] → a.
- Fixed signatures for some
Branchvariants, bringing type parameter
ainto parens.
- Clarification about number of
VecTreevs pairing constructors in remarks on left- vs right-folded trees.
- 2011-02-06: Fixed link to From Fast Exponentiation to Square Matrices.


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This week we are giving away a pair of tickets to see Cowboy Mouth at the 9:30 Club on January 26. Tickets for this concert are available on Ticketfly or at the 9:30 Club box office.
For your chance to win these tickets simply leave a comment on this post using a valid email address by 5pm today. One entry per email address, please. Comments will be closed at 5pm and a winner will be randomly selected. The winner will be notified by email. The winner must respond to our email within two hours or they will forfeit their tickets and we will pick another winner.
Tickets will be available to the winner at the 9:30 Club Guest List window one hour before doors open on the night of the concert. The tickets must be claimed with a valid ID. The winner must be old enough to attend the specific concert or must have a parent's permission to enter if they are under 18 years old.
If today does not turn out to be your lucky day, check back here each Wednesday for a chance to win tickets to other great concerts


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Fujitsu was (and still is) japan's leading electronics company. This computer was the succesor of the FM-8 itself first member of the Fujitsu FM (for "Fujitsu Micro") range of computers, extending from hobbyist home computers up to 16-bit machines for the business market.
The FM-7 was conceived as a cut-down version of the FM-8, eliminating the bubble cassette feature, and thereby achieving greater compactness and significantly lower price. But it also offered features not found on the FM-8, like a real sound synthesizer LSI providing 3 voices and 8 octaves. This made it the ideal hobby japanese computer at the time.
As the NEC PC series and the Sharp X1 and X68000, these computers were very very popular in Japan. They all had impressive characteristics in relation to the European and American computers counterparts.
The Most outstanding feature of the FM-7 was the quality and speed of the graphic display.
On the Japanese Computer Museum, one can read:
"Later, it developed into the FM-NEW7, which used high-integration memory and gate array LSI to reduce price while maintaining FM-7 functionality, and a high-end machine called the FM-77. From the start, the FM-7/77 series emphasized high-resolution color graphics and Japanese language display, and this trend continued with AV (Audio Visual) personal computers (beginning with the subsequent FM-77 AV) and the FM TOWNS hypermedia personal computer. The FM-7/77 machines laid the groundwork for Fujitsu's later hobby machines."
Nomura, Hisayuki reports:
Fujitsu FM 8 / 7 have a very unique feature. They have 2 CPUs. 1 for Main CPU (it's usual) and 1 for Graphics. Graphic CPU has their own boot ROM and main program. The Grapic CPU recieves request from Main CPU and draw pictures with their software. The two CPUs share small part of memory area and uses this shared area exclusively.
As another unique feature, the FM-7 can change its CPU. If optional Z-80A card is inserted, it can run CP/M. In this case, memory is shared by the two different CPUs.
Joerg Lemmer's memories:
We had the FM7 as our first "real computers" in school. As the teachers had no understanding in computers at all they first bought the FM7 and then found out that there was no software available for them in Germany. So Z80-cards were bought and installed. By this a modified CP/M could be used with just two applications: An early version of WordStar and TurboPascal. I am not sure, but I think there was dBase running on the FM7 later.
One teacher even started programming a library to use the outstanding grafic card of the FM 7 in TurboPascal.
We had FM 7 with single and dual external 5,25'', 170KB Diskdrives.
FM-7 was my first PC and I learned a lot of things from this. These era ('80), was exciting years for PC users. Tons of unique PC was released. But now, we have only 2. PC and MAC. Sigh...
FM-7 was my first PC and I learned a lot of things from this. These era ('80), was exciting years for PC users. Tons of unique PC was released. But now, we have only 2. PC and MAC. Sigh...


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Thank you for choosing to book your Disney stay with DVC Shop!To confirm your reservation, please complete the booking form below. Once DVC Shop receives your completed Booking Form, we will book your room for you within a timely manner.
Your Booking Details (ID #261485)
Disney's Bay Lake Tower
08/01/2024 - 08/05/2024, 4 nights
Deluxe Studio - Standard View
Sleeps 4
Views of Parking Area or Obstructed View 1 queen-size bed, 1 double-size sleeper sofa
Total $1,877.40
$1,800.00 + $77.40 processing fees


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This composite shows four examples of "browse" products the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) instrument obtained of areas on Mars near proposed landing sites for NASA's 2009 Mars Science Laboratory. These examples are from two of more than 30 candidate sites. They are enhanced color images of West Candor chasm (A) and Nili Fossae trough (B); and false color images indicating the presence of hydrated (water-containing) minerals in West Candor (C); and clay-like (phyllosilicate) minerals in Nili Fossae (D).
CRISM is one of six science instruments on NASA's Mars Reconnaissance Orbiter. Led by The Johns Hopkins University Applied Physics Laboratory, Laurel, Md., the CRISM team includes expertise from universities, government agencies and small businesses in the United States and abroad. NASA's Jet Propulsion Laboratory, a division of the California Institute of Technology in Pasadena, manages the Mars Reconnaissance Orbiter and the Mars Science Laboratory for NASA's Science Mission Directorate, Washington. Lockheed Martin Space Systems, Denver, built the orbiter.


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10+ Unbelievable K-Pop Facts That'll Make You Go "WHAT?!"
1. Red Velvet's Irene is 8 years older than Yeri
If this age gap isn't surprising enough, keep in mind that Irene is also older than many of her seniors. This includes HyunA, Sunmi, 5 Apink members, 3 Girl's Day members, 2 SISTAR members, and all but one of MAMAMOO's members, among others. She is only one month younger than CL!
2. KARD's Somin and TWICE's Jeongyeon are related.
Jeongyeon is the niece of Somin's father's younger brother's wife. This makes them cousins by marriage! They are also the same age and get along together well.
3. BLACKPINK's 5th member debuted in another group.
There were originally going to be 9 members in BLACKPINK, but this number eventually got cut down to 4. Among these 5 members who did not debut with BLACKPINK was a trainee named Miyeon, who has now gone on to debut as a member of (G)I-DLE.
4. SHINee's Taemin is only 25 years old, but he has 11 years of work experience.
Taemin was born on July 18, 1993. That made him one of the youngest trainees to ever make his debut, back in 2008. Other young debuts currently include Wonder Girls's Ahn Sohee (14), BTS's Jungkook (15), and IU (15).
5. BOYSTORY and HI CUTIE are two of the youngest idol groups on the K-Pop scene.
At the time of their debut, HI CUTIE has an average age of 12.6 years old, while BOYSTORY's average age is 13.
6. The Honey Popcorn members all used to be adult video actresses.
This Japanese membered girl group created quite the stir when their formation was announced. Prior to becoming adult-film-actresses-turned-idols, Yua Mikami, Miko Matsuda, and Moko Sakura were part of different Japanese girl groups.
7. Park Joon Hyung is the oldest active K-Pop singer.
The leader of g.o.d, Park Joon Hyung, will be turning the big 5-0 this July! He is also older than two of "The Big 3's" founders, Park Jin Young (JYP Entertainment)and Yang Hyun Suk (YG Entertainment).
8. The Boyz's "farm boy" Joo Haknyeon has a rich family.
During Produce 101, Joo Haknyeon had a "farm boy" image. When the average city-dweller thinks of a farm, they may picture a modest barn with livestock milling around. Joo Haknyeon's family, on the other hand, operates a commercial farm with thousands of pigs. It must have made them very wealthy folks because they allegedly own several residences in addition to their Jeju Island farm. Fans have nicknamed Joo Haknyeon "Jeju's Paris Hilton"!
9. BIGBANG's G-Dragon trained for 11 years before debuting.
G-Dragon spent 5 years as a trainee in SM Entertainment, where he specialized in dance before leaving to discover himself. After he found his love for rapping he joined YG Entertainment then continued to train until he made his debut 6 years later, with BIGBANG in 2006.
10. TWICE's Jihyo trained for 10 years before debuting.
G-Dragon isn't the only trainee who worked his tail off for a decade! Jihyo also spent most of her young life as a trainee before making her debut in 2015.
11. MOMOLAND's Nancy is the youngest member but has the most experience.
Nancy may be the maknae, but in terms of experience, she's actually MOMOLAND's veteran! She trained for 6 years before debuting.
12. Minzy (former 2NE1 member) has a famous great-aunt.
Fame seems to run in Minzy's family, because her great-aunt was the famous folk dancer, Gong Ok Jin, who was best known for her "hunchback dance".


text: Dr Steve Publicover BSc PhD In 'People' StaffResearch FellowsHonorary staff Back to 'School of Biosciences' School of BiosciencesReader Contact details Telephone+44 (0)121 41 45455 Fax+44 (0)121 41 45925 email@example.com View my research portal AddressSchool of BiosciencesThe University of BirminghamEdgbastonBirmingham B15 2TTUK Dr Steve Publicover is an internationally-recognised expert on sperm physiology and signalling events in sperm initiated by sperm-egg interaction. Qualifications BSc (University of Liverpool) PhD (University of Liverpool) Biography I obtained my BSc and PhD at Liverpool. I have worked on ion channels and cell signalling (primarily Ca2+) in the physiology and pathology of a number of cell types. Initially this work was focussed on synaptic transmission, synaptic plasticity and Ca2+-mediated cell death in excitable cells. After moving to Birmingham, I worked on signalling in mammalian bone, particularly the putative glutamatergic signalling network. My laboratory now concentrates on human sperm physiology and sperm-egg signalling. We are studying signalling events (primarily [Ca2+]i signalling and ion channel regulation) evoked by interaction of sperm with the oocyte-cumulus complex and the female tract. Teaching Areas of teaching include neurobiology and nervous systems (taught to all three undergraduate years), cellular physiology and reproductive biology. I have a background in zoology and also contribute to teaching on animal diversity. Postgraduate supervision For a list of possible PhD projects offered by Dr Publicover www.findaphd.com/search/customlink.asp?inst=birm-Biol&supersurname=Publicover Research Research Theme within School of Biosciences:Molecular and Cell Biology Lab website address: http://www.biosciences-labs.bham.ac.uk/publicover/ Ca2+ signalling and regulation of function in human sperm. I have worked on ion channels and cell signalling (primarily Ca2+) in the physiology and pathology of a number of cell types. Initially this work was focussed on synaptic transmission, synaptic plasticity and Ca2+-mediated cell death in excitable cells. After moving to Birmingham, I worked on signalling in mammalian bone, particularly the putative glutamatergic signalling network. My laboratory now concentrates on human sperm physiology and sperm-egg signalling. We are studying signalling events (primarily [Ca2+]i signalling and ion channel regulation) evoked by interaction of sperm with the oocyte-cumulus complex and the female tract. Our primary area of interest is the role(s) of Ca2+ signalling and post-translational protein modification in regulation of the activities of human spermatozoa (particularly motility) in response to factors encountered by the sperm in the female tract, both from the tract itself and from the oocyte and its surrounding cumulus cells. We are using ion-imaging, electrophysiological and molecular techniques, together with standard techniques for assessment of motility, to study signal transduction and downstream responses in human sperm. Publications Mansell, S.A., Publicover, S.J, Barratt, C.L.R., Wilson, S.A. (2014) Patch clamp studies of human sperm under physiological ionic conditions reveal two functionally and pharmacologically distinct cation channels. Human Reproduction (in press) Tavares,S, Mansell, Barratt, CL, Publicover, S, Ramalho-Santos, J.(2013) DDE activates CatSper and compromises human sperm function at environmentally-relevant concentrations . Human Reproduction 28:3167-77 Jones S, Lukanowska M, Suhorutsenko J, Oxenham S, Barratt C, Publicover S, Copolovici DM, Langel U, Howl J. (2013) Intracellular translocation and differential accumulation of cell-penetrating peptides in bovine spermatozoa: evaluation of efficient delivery vectors that do not compromise human sperm motility. Hum Reprodroduction. 28:1874-89 Alasmari, W, Costello S, Correia J, OxenhamS, Morris J, Fernandes L, Ramalho-Santos J, Kirkman-Brown J, Michelangeli F, Publicover S, Barratt C (2013) Ca2+ signals generated by CatSper and Ca2+ stores regulate different behaviours in human sperm J. Biol Chem 288, 6248-6258 Alasmari,W, Barratt, CLR, Publicover, SJ,Whalley, KM, Foster, E, Kay, V, Martins da Silva, S and Oxenham , SK (2013) The incidence and clinical significance of defects in calcium signalling pathways mediating human sperm hyperactivation Human Reproduction 28:866–876 Baptista M, Publicover SJ, Ramalho-Santos J.(2013) In vitro effects of cationic compounds on functional human sperm parameters. Fertil Steril. 99:705-712 Lefièvre L, Nash K, Mansell S, Costello S, Punt E, Correia J, Morris J, Kirkman-Brown J, Wilson SM, Barratt CL, Publicover S. (2012) 2-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm. Biochem J. 448:189-200 Mota PC, TavaresRS, Cordeiro, M, Pereira, SP, Publicover, SJ,. Oliveira, PJ Ramalho-Santos, J (2012) Acute effects of TCDD administration: special emphasis on testicular and sperm mitochondrial function. Asian Pacific J Reproduction 1: 269-276 Publicover SJ, Barratt CL. (2012) Chloride channels join the sperm 'channelome'. J Physiol. 590:2553-4. Barratt CL, Publicover SJ. (2011) Sperm are promiscuous and CatSper is to blame. EMBO J. 31:1624-6. Publicover S, Barratt C.(2011) Progesterone's gateway into sperm. Nature. 471:313-4 Wu J, Wang S, Publicover SJ, Gu Y, Franklin-Tong VEF. (2011) Self-incompatibility in Papaver rhoeas activates a non-specific cation conductance permeable to Ca2+ and K+. Plant Physiology 55:963-73. Nash K, Lefievre L, Peralta-Arias R, Morris J, Morales-Garcia A, Connolly T, Costello S, Kirkman-Brown J, Publicover S (2010) Techniques for Imaging Ca2+ Signaling in Human Sperm. JOVE http://www.jove.com/index/Details.stp?ID=1996 Teves, ME,. Guidobaldi, HA, Uñates, DR, Raul Sanchez, R, Miska, W, Stephen J., SJ, Morales Garcia, AA, Giojalas, LC (2010) Molecular Mechanism for Human Sperm Chemotaxis Mediated by Progesterone. PLOS One 4: e8211 Costello S, Michelangeli F, Nash K, Lefievre L, Morris J, Machado-Oliveira G, Barratt C, Kirkman-Brown J, Publicover S. (2009) Ca2+ stores in sperm: their identities and functions. Reproduction 138, 425-437. Lefièvre L, Machado-Oliveira G, Ford C, Kirkman-Brown J, Barratt C, Publicover S. (2009) Communication between female tract and sperm: Saying NO* when you mean yes. Commun Integr Biol ;2, 82-85. Wang, S, Publicover, SJ, Gu, Y (2009) A novel oxygen-sensitive mechanism for regulation of the epithelial sodium channel (ENaC) Proc Nat Acad Sci USA. 106:2957-62. K Bedu-Addo, S Publicover. (2008) Characterization of the Ca2+ channels involved in the progesterone-induced Ca2+ influx and acrosome reaction (AR) in human spermatozoa. Journal of the Ghana Science Association 10:166-177 Machado-Oliveira,G, Linda Lefièvre, L, Ford, WCL, Herrero, MB, Barratt, CLR, Connolly, T, Nash, K, Morales-Garcia, A, Kirkman-Brown, J, Publicover, SJ. (2008) Mobilisation of Ca2+ stores and flagellar regulation in human sperm by S-nitrosylation: a role for NO synthesised in the female tract. Development 135, 3677-3686 Harper CV, Cummerson JA, White MRH, Publicover SJ, Johnson PM (2008) Dynamic resolution of acrosomal exocytosis in human sperm. J Cell Sci 121:2130-5 K Bedu-Addo; S Costello, CV Harper, GSM Machado-Oliveira, L Lefievre, WCL Ford, CLR Barratt, SJ Publicover (2008) Mobilisation of stored Ca2+ in the neck region of human sperm - a mechanism for regulation of flagellar activity. Int J Dev Biol . 52: 615-626 Publicover SJ, Giojalas LC, Teves ME, Machado-Oliveira GS, Morales-Garcia AA, Barratt CLR, Harper CV (2008) Ca2+ signalling in the control of motility and guidance in mammalian sperm. Frontiers in Bioscience 13:5623-37 Jimenez-Gonzalez MC, Gu Y, Kirkman-Brown J, Barratt CL, Publicover S. (2007) Patch-clamp 'mapping' of ion channel activity in human sperm reveals regionalisation and co-localisation into mixed clusters. J Cell Physiol. 213:801-808 Lefievre L, Chen Y, Conner SJ, Scott JL, Publicover SJ, Ford WC, Barratt CL. (2007) Human spermatozoa contain multiple targets for protein S-nitrosylation: An alternative mechanism of the modulation of sperm function by nitric oxide? Proteomics. 17:3066-84. Lefievre L, Bedu-Addo K, Conner SJ, Machado-Oliveira GS, Chen Y, Kirkman-Brown JC, Afnan MA, Publicover SJ, Ford WC, Barratt CL. (2007) Counting sperm does not add up any more: time for a new equation? Reproduction. 133:675-84 Publicover, SJ, Harper CV, Barratt, CLR (2007) [Ca2+]i signalling in sperm - making the most of what you've got. Nature Cell Biol 9:235-42 K Bedu-Addo, CLR Barratt, J.C. Kirkman-Brown, SJ Publicover (2007) Patterns of [Ca2+]i mobilization and cell response in human spermatozoa exposed to progesterone. Developmental Biology 302:324-32 Conner SJ, Lefievre, L., Kirkman-Brown, J, Michelangeli, F, Jimenez-Gonzalez, C, Machado-Oliveira, GSM, Pixton, KL, Brewis, IA, Barratt, CLR, Publicover SJ (2007) Understanding the physiology of pre-fertilsation events in human spermatozoa - a necessary prerequisite to developing rational therapy. Soc Reprod Fertil Suppl. 63:237-55. Harper CV, Barratt CL, Publicover S, Kirkman-Brown JC. (2006) Kinetics of the progesterone-induced acrosome reaction and its relation to intracellular calcium responses in individual human spermatozoa. Biol Reprod. 75:933-9. Billington RA, Harper C, Bellomom Sc EA, Publicover S, Barratt CL, Genazzani AA (2006) Characterization of cyclic adenine dinucleotide phosphate ribose levels in human spermatozoa. Fertil Steril. 86:891-8. Jimenez-Gonzalez C, Michelangeli F, Harper CV, Barratt CL, Publicover SJ. (2006) Calcium signalling in human spermatozoa: a specialized 'toolkit' of channels, transporters and stores. Hum Reprod Update. 12:253-67 Hughes S, Magnay J, Foreman M, Publicover SJ, Dobson JP, El Haj AJ. (2006) Expression of the mechanosensitive 2PK+ channel TREK-1 in human osteoblasts. J Cell Physiol. 206:738-48 Foreman MA, Smith J, Publicover SJ. (2006) Characterisation of serum-induced intracellular Ca2+ oscillations in primary bone marrow stromal cells. J Cell Physiol. 206:664-71 Brewis IA, Van Gestel RA, Gadella BM, Jones R, Publicover SJ, Roldan ER, Frayne J, Barratt CL. (2005) The spermatozoon at fertilisation: current understanding and future research directions. Hum Fertil (Camb). 8:241-51 Bedu-Addo K, Lefievre L, Moseley FL, Barratt CL, Publicover SJ. (2005) Bicarbonate and bovine serum albumin reversibly 'switch' capacitation-induced events in human spermatozoa. Mol Hum Reprod. 11:683-91 Moseley FL, Jha KN, Bjorndahl L, Brewis IA, Publicover SJ, Barratt CL, Lefievre L. (2005) Protein tyrosine phosphorylation, hyperactivation and progesterone-induced acrosome reaction are enhanced in IVF media: an effect that is not associated with an increase in protein kinase A activation. Mol Hum Reprod. 11,523-529. Harper C, Wootton L, Michelangeli F, Lefievre L, Barratt C, Publicover S. (2005) Secretory pathway Ca2+-ATPase (SPCA1) Ca2+ pumps, not SERCAs, regulate complex [Ca2+]i signals in human spermatozoa. J Cell Sci. 118,:1673-1685. Harper CV, Publicover SJ. (2005) Reassessing the role of progesterone in fertilization--compartmentalized calcium signalling in human spermatozoa? Hum Reprod. 20, 2675-80 M Foreman, Y Gu, J Howl, S Jones and S. Publicover. (2005). Group III metabotropic glutamate receptors are expressed in bone marrow stromal cells and are negatively coupled to nitric oxide synthase. J Cell Physiol 204, 704-713 C Kirkman-Brown, CLR Barratt , SJ Publicover. (2004) Slow calcium oscillations in human spermatozoa Biochem J 378, 827-832 Y Gu, J C Kirkman-Brown, Y Korchev, CLR Barratt, SJ Publicover (2004) Multi-state, 4-aminopyridine-sensitive ion channels in human spermatozoa. Dev Biol 274, 308-317 Harper CV, Barratt CL, Publicover SJ. (2004) Stimulation of human spermatozoa with progesterone gradients to simulate approach to the oocyte. Induction of [Ca2+]i oscillations and cyclical transitions in flagellar beating. J Biol Chem. 279, 46315-25 JC Kirkman-Brown, CLR Barratt SJ Publicover (2003). Nifedipine reveals the existence of two discrete components of the progesterone-induced [Ca2+]i transient in human spermatozoa. Dev Biol 259, 71-82 Claire V Harper, Jackson C.Kirkman-Brown, Christopher LR Barratt & Stephen J Publicover (2003) Encoding of progesterone stimulus-intensity by [Ca2+]i in human spermatozoa. Biochem J 372, 407-417View all publications in research portal


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Conectează-te ca să te putem notifica când primești un răspuns
With the versatile SanDisk Sansa Fuze+ MP3 player, you'll get more features for less money. You'll be able to watch video on the 2.4-inch screen, share photos, listen to FM radio, record voice memos, and more--all in a device that is just 0.43-inches thin. Internal memory and a microSDHC expansion slot give you plenty of storage options for your digital media, and you can expand your enjoyment even further by adding an optional slotRadio card for an instant library of songs.
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Some implementation notes:
Support was added for
to the MySQLi extension in PHP 5.3.
Note there are different internal implementations within
libmysqlclient and
mysqlnd for handling
columns of type
MYSQL_TYPE_GEOMETRY. Generally speaking,
mysqlnd will allocate significantly less memory. For
example, if there is a
column in a result set,
libmysqlclient may pre-allocate up
to 4GB of RAM although less than 50 bytes are
needed for holding a
POINT column in memory. Memory
allocation is much lower, less than 50 bytes, if


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Sanjaya: Human Art Project
Is Sanjaya Malakar really who he says he is ... or is he really an art school student pretending to be an "Idol" wannabe?
TMZ received a hilarious video of Sanjaya explaining that his "real" name is Bill Vendall, and that he is an art student at the Rhode Island School of Design. He "created" Sanjaya as part of his thesis, explaining, "The character was part of a larger art installation." That still doesn't justify the hair!
Sanjaya (or is it Bill?) also declares that you haven't seen the last of him, saying, "I might pop up on your favorite situation comedy. I might run for President. I might show up as you." Oooooooh, scary.


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Empire Earth 2
Cheat Codes:
Update by: Kesang Chhantyal
Submitted by: Haspa
Update by: Phuc
In the game hit [Enter] to open the console and type in the following codes and
confirm them with [Enter]:
Result Code
Disables all Cheat Codes - idontcheat
Enables all of the Following Codes - icheat
Add 10,000 of each resource - loot
Subtract 100 of each resource - taxes
Inflict 20 points of damage on selected unit - punish
Convert selected unit - convert
Instant recharge power for selected unit - recharge me
Instantly win scenario (May be disabled) - win
Toggle the fog of war onoff - toggle fog
Toggle instant build onoff - sea monkeys
Advance an epoch without meeting any of the requirements - epoch up
Add 50 technology points - give tech
God Mode onoff (Your Units and Building should take no damage)- play god
Additional 100 troops - reinforcements
In the game you might press two debug key combinations:
[Ctrl]+[Alt]+[Shift]+[V] - Display the Game Version numbers
[Ctrl]+[Alt]+[Shift]+[F] - Display the Graphical Frames Per Second Rate (FPS)
Hill Advantage:
Troops have problems charging up slopes. That means that if you have your base built at the
top of a hill or a series of troops there, etc, then you have the advantage in that battle.
An example could be me placing my units on top of the hill. They could all be archers, and
while the enemy forces trudge up the hill, I can rain arrows down on them. Then, when they
are about to make it to the top, charge down the other side. Although they will be close
behind you, if your units are fast enough, then they won't be able to catch you.
Unstopabul army:
There are three steps to this tip.
1 - Use epoch up to advance epochs
2 - Advance epochs till you can buy choppers
3 - Use the money cheat for awhile
4 - Use loot cheat for awhile
5 - Buy as meany choppers you can
6 - Desemate your opponents army, buildings, or what ever you want
Woods and Forests: Dogs and Barbarians:
This is especially useful for those of you who like to be able to see a lot of points on the
map. Take any of the top two units and place them in the forests, and you should have a scout
placed anywhere you want with little chance of being injured. Same with the Barbarians, only
they can also be used for ambushes and getting to those little soft areas in the enemies defence.
Of course, if you are using the former, make sure that the enemy does not send the latter
(Barbarian) after you!
Epoch Limits and Civ Points:
In multiplayer games where you make your own race, be sure to check what type of Epochs are
going to be in it and if there is a limit. If, say, the bronze age is the end of the games
ability to expand for that game, that means that any units you invested for afterwards are
now useless. Always check to make sure that you can't spend any more points in those that
you want. If you can not find anything you really want to invest it in, find something that
is more passive in your civilization and drop those points that are left into it.
The economy, for example. You may have a powerful army, but you will never get one of any size
quickly enough without the economy as your backbone.
Win and learn more:
Submitted by: Arpan
Select the campaign menu and select the American civilization and hit enter after the game
starts. again hit enter and type "icheat",this will enable cheats again hit enter and type
"win",you eill win the game and keep winning...you will learn about the future upto 2070
A.D.this win cheat may be disabled sometimes,,,
if you want to be my friend then here goes my mail: firstname.lastname@example.com


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Interview With Cindy Hill About Problems Facing Education [AUDIO]
Wyoming Superintendent of Public Instruction, Cindy Hill, has been making headlines over the past several months, after her elected position was stripped of most of its powers by legislative action.
Lawyers for the state are now conceding that the bulk of the bill stripping most duties from the superintendent of public instruction is unconstitutional.
This after Hill sued the state. The Supreme Court ruled in January that lawmakers overstepped their authority in passing the legislation. The court later refused to reconsider the case.
The case is currently before a District Court judge.
Hill is now speaking out about problems facing education in the state. Here's an interview with Hill conducted by Trevor T. Trujillo:


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When MyNorth challenged Grand Traverse Resort's Executive Chef Joseph George to our local foods showdown he accepted with gusto and prepared a delicious take on bacon and eggs—Bacon and Eggs with Crispy Fingerling Potato Pancake, Smoked Steelhead Roe, Bourbon Infused Maple Syrup. In accordance with the rules of the showdown, 90 percent of the ingredients for this dish are from Northern Michigan and another 5 percent are from Michigan, making it a 95 percent made-in-Michigan dish.
Watch the video to learn Chef George's technique. Then click for the recipe: Bacon and Eggs with Crispy Fingerling Potato Pancake, Smoked Steelhead Roe, Bourbon Infused Maple Syrup.
Here is a list of the local ingredients George used in the dish:
- Fingerling potatoes, celery micro greens: Werp Farms, Karlin
- Wild leeks, locally foraged
- Smoked steelhead roe, Bourbon infused maple syrup, aged sherry vinegar, Blis, Grand Rapids, blisgourmet.com
- Egg, Bakers Green Acres, Marion
- Pancetta- Made at Grand Traverse Resort with Michigan Pork Belly, grandtraverseresort.com
More Chef Showdown: Local Foods Videos
- Watch Executive Chef Darren Hawley of Crystal Mountain Resort prepare Smoked Pheasant with Morel Galantine.
- Watch Martha Ryan, of Martha's Leelanau Table Prepare Leelanau Raclette Fondue with over 90% local foods from Northern Michigan. And then get the recipe.
- Watch Eric Nittolo of the Boathouse Restaurant prepare Rack of Lamb with Parsnip Puree.
- Watch Sam Hybel of Gusto in Suttons Bay prepare asparagus with white wine sauce.
- Watch Chef John Piombo of Nonna's at The Homestead in Glen Arbor prepare Goat Cheese and Kale Spelt Ravioli with Roasted Rabbit, Asparagus and Cream
- Watch Randy Chamberlain of Blu in Glen Arbor prepare malted cherry ice cream.


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Celebrity News June 24, 2014
Pics! Jennifer Aniston and Justin Theroux's PDA-Packed Night in NYC
Jennifer Aniston and Justin Theroux hit the red carpet together on Monday night for the first time in nine months. What was the special occasion? The NYC premiere of Justin's new HBO show, "The Leftovers."
Aniston chose a sexy black shirt dress and studded stilettos for her fiancé's big night, while Theroux went for the classic look in a Dior Homme suit and handlebar neck tie.
The night began when the pair arrived to the red carpet hand in hand. They were all over each other as photographers snapped away, Jen showing off her 8-carat, half-million-dollar engagement ring.
Justin told "Extra" the two are still "happily engaged," adding that when it comes to wedding plans, "You guys are in more of a rush than we are. We have hot feet, but we're not going to let you guys know."
Theroux also dished on his character in "The Leftovers." In the thriller, he plays a suburban cop trying to keep order after the sudden and unexplained disappearance of part of the world's population.
The actor told us, "He's a chief of police that's not necessarily in charge. He's the guy trying to bring the stick down on the back of his own town."
Catch HBO's premiere of "The Leftovers," Sunday at 10 PM.