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'Let It Be' returns to the West End on Feb 28 2015.
Some day, somebody will surely write an absolutely stonking Beatles musical, one that will turn the astonishing journey of the most successful band of all time into a mind-frazzling odyssey of fearless sonic exploration, Jacobean grade emotional strife and general '60s grooviness.
'Let It Be' is not that musical. In fact, it's not even really a musical: it's basically a posh tribute gig, masterminded by one Joey Curatolo, mainstay of long-running US Beatles revue 'Rain'. And it is what it is: four blokes wearing wigs, playing instruments and changing costumes while bashing out proficient covers of the Fab Four's greatest hits in roughly chronological order.
With the stage flanked by kitschy big screens displaying Beatles trivia and a first section slavishly adherent to the band's clean cut early TV appearances, it gets off to an overly nostalgic start: sexless, rinky-dink takes on 'She Loves You', 'Please Please Me' et al rattled out without any of the guts or élan of a real gig.
But the Beatles ceased to play live in their later, more productive years, and 'Let It Be' moves up a gear when it stops trying to recreate archive footage and starts imagining what might have been. The 'Sgt Pepper's' section offers a ravishing wall of psychedelic sound and impressive day-glo costumes, while a delightfully loose acoustic run through late classics 'Blackbird', 'The Two of Us' and 'While My Guitar Gently Weeps' benefits from the odd flubbed note – the sterility of the early sections is gone, and the four musicians playing together actually sound like a real band.
In fact there are two bands, which play on different nights. The one I saw had a ropey Ringo – Phil Martin's drumming was fine, but his rendition of 'With A Little Help from My Friends' was bizarrely dolorous – and a slightly grating George – John Brosnan's singing was tolerable, but his cock rock riffing was not.
But Ian B Garcia's Paul McCartney and Michael Gagliano's John Lennon have the distinct vocals of the Beatles' twin leaders pretty much nailed and sing the later material with great force and gusto.
I could really have done without the attempts at in-character banter ('If you love peace… you'll put your hands together for this one.'), but by the time inevitable closer 'Hey Jude' comes around, you'd pretty much have to be in the wrong show not to be enjoying yourself.
You won't learn anything about the Beatles from 'Let It Be', and the production feels on the cheap side for a show of its scale – brass and strings etc all come from a bloke on a very un-'60s synth. If ambition was The Beatles' defining trait, there isn't a huge amount here. But it's likeable, with a well-chosen set list. And if you didn't already know that the songs are astonishingly good then there are far worse introductions. Andrzej Lukowski


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Lund EX ExtraWide Fender Flares for F-250 Super Duty/F-350 Super Duty [Front, Standard] | EX314SA
Or 3 interest-free payments of $65.00 with Affirm.
Find this for your car.
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- Not your vehicle? See all Lund Elite EX ExtraWide Style Fender Flares
- Custom fit fender flares, front set. Standard.
- Catalog Number: Lund EX314SA
- Fits: Ford F-250 Super Duty, Ford F-350 Super Duty (check fitment chart for compatibility)
Lund EX ExtraWide Fender Flares for F-250 Super Duty/F-350 Super Duty [Front, Standard] | EX314SA
Product Specifications:
- Color: Black
- Color Group: Black
- Drilling Required: No
- Finish: Matte
- Flare Height: 6-3/4 Inch
- Includes Lights: No
- Includes Mounting Hardware: Yes
- Installation Type: Screw-On
- Material: Tri-Flex ABS Smooth Thermoplastic
- Paintable: Yes
- Quantity: Set Of 2
- Style: Extra-Wide
- Tire Coverage: 2-1/4 Inch
Fitment Chart:
|Bed Type
|F-250 Super Duty
|2 pc. Flare Height 6.75 in. Flare Tire Coverage 2.25 in.
|F-350 Super Duty
|2 pc. Flare Height 6.75 in. Flare Tire Coverage 2.25 in.
Extra coverage and protection for large wheels
The Lund EX314SA Extra-Wide fender flares are made with large tires in mind. They extend to provide excellent coverage and protection to large wheels. They also give your Ford F-250 Super Duty an aggressive and bold look.
Available in smooth and textured finishes
You can get the flares in a smooth black finish which is ideal for a simple but classy look. There is also a textured option for an extra layer of aggressive.
Made with UV resistant material
The fender flares are made with UV resistant material. They will serve you for years without dulling, fading or chalking.
As-is installation
The Lund EX314SA Extra-Wide fender flares do not require painting to look great. You can install them as-is in their custom black finish, and they are guaranteed to look great on your Ford F-250 Super Duty regardless of its color or style.
Easy to paint (smooth only)
If you are looking to customize the flares, you can easily do so by painting them. They look great in any color and will match well with your Ford F-250 Super Duty's style if the paint is chosen carefully.
No-drill installation
The flares can easily be mounted on without any drilling or cutting. They cut with pre-drilled holes which can be clipped onto the fender and fastened tight with the bolts and screws.
Premium-grade OE materials
Lund EX314SA Extra-Wide fender flares are made with high-quality OE materials. They are built strong to withstand harsh weather elements and tough road debris. They are extra durable to maintain their value and serve you for years after their purchase.
All installation hardware
You don't need to make any extra purchases for the installation of the flares. The package includes all the necessary hardware you will need, including the rubber seal, stainless steel bolts, and fastening clips.
Limited lifetime warranty
As proof of the excellent quality of the flares, Lund provides you with a limited lifetime warranty on purchase. It protects you against damages caused by faulty crafting or defective material.
Made in the USA
The Lund EX314SA Extra-Wide fender flares are proudly made in the USA. They are authentic, durable, and crafted with a high level of artistry.

subset: commoncrawl


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With the new Congress now in session, lawmakers have been rushing to unveil legislation to rein in rising drug prices, and the Trump administration's top health official has been talking tough about the issue.
* Sen. Chuck Grassley (R-IA), the new chair of the Senate Finance Committee, laid out three bills this week as top priorities. They include a proposal put forth with Sen. Amy Klobuchar (D-MN) to allow Americans to import drugs from Canada for personal use and a bill to ban "pay for delay" agreements in which manufacturers of brand-name drugs pay the makers of generics to delay production of competitors. (Grassley remains opposed to legislation allowing Medicare to negotiate directly with drug companies, and he doesn't favor the Trump administration's proposal to tie certain Medicare drug payments to prices that European countries pay.)
* Sen. Bernie Sanders (I-VT) and some Democrats on Thursday unveiled three bills aimed at lowering drug prices. The bills, according to the Associated Press, would allow consumers to import medications from Canada; let Medicare to directly negotiate with drugmakers; and strip exclusive licenses from pharmaceutical companies and open up generic competition for drugs whose prices are higher than the median price in Canada, the United Kingdom, Germany, France and Japan. The international pricing proposal would apply to any patent-protected brand-name drug — far more than under the Trump administration's similar proposal.
"The Democratic bills stand little chance of becoming law in a divided government. But the effort could put Republicans on the defensive by echoing Trump's pledge to force drugmakers to cut prices," the AP's Ricardo Alonso-Zaldivar writes.
The Trump administration has ramped up the political rhetoric against drugmakers as well. Health and Human Services Secretary Alex Azar sent a stern-sounding warning this week to drugmakers who raised prices to start the new year (see the Bloomberg chart below for some examples).
"Maintaining the status quo, where higher priced drugs are more competitive and patients pay more, is unacceptable. Companies that announced price increases in January admitted they were doing so to funnel payments back to PBMs in order to keep the preferred status of their drugs," Azar tweeted Wednesday. "For those listening in the pharmaceutical industry: The list price increases must stop. Prices must start coming down."
He offered a similar message in a Fox Business interview: "I want to be really clear to the pharma companies out there and to the pharmacy benefit managers: The president and I will not stop until list prices of drugs come down. This behavior has to stop. Drug prices must come down. And we will roll out more regulatory and legislative proposals, and we will work with Democrats and Republicans to get drug prices down."
Trump himself tweeted Saturday that "Drug makers and companies are not living up to their commitments on pricing. Not being fair to the consumer, or to our Country!" And he called Azar and other top officials to the White House for a meeting on drug prices Tuesday.


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The interconnection of the natural world has long been part of human wisdom. "All the rivers run into the sea," notes Ecclesiastes, and they do this even if they are streams that do not flow all year. As long as water flows downhill, pollution in one place can be carried to another.
So it makes sense that the Environmental Protection Agency has long sought to recognize this reality. But Supreme Court rulings in 2001 and 2006 have confused the understanding of which waterways can be subject to EPA rules. On March 25 it issued a proposal to clarify that intermittent streams near bigger ones will be covered.
Although the 1972 Clean Water Act gave the EPA power to regulate pollution in "navigable waters," Congress defined those broadly as "the waters of the United States, including the territorial seas." In 1985, the Supreme Court held that a wetland next to a body of navigable water was subject to the EPA.
But in 2006 Associate Justice Antonin Scalia said that the EPA's power did not extend to saturated fields miles from a bigger body of water. Out of the confusion of this case and another earlier comes the proposal of the new clarifying rule.
Specifically, the proposal states the most seasonal and rain-dependent streams are protected, as are wetlands near rivers and streams. Other types of waters that may have more uncertain connections to downstream water will be evaluated in a case-by-case analysis. In sum, thousands of miles of headwaters, streams and wetlands will return to EPA oversight.
The EPA says it worked with stakeholders who have sought clarity, but the rule is being opposed by more than a dozen GOP senators, led by Pennsylvania's Pat Toomey, with the support of some farmers. He denounced the EPA's action as a "terrifying power grab," saying the "new position seems to be that a puddle from your garden hose will ultimately end up in a navigable waterway."
No, that is just over-the-top rhetoric speaking. With science on its side, the EPA isn't interested in regulating puddles or ditches. It is not seeking to shield any new waters not historically covered under the Clean Water Act. It just wants to get on with the job of protecting the environment, which has benefited Americans hugely over the years.
Editorial by the Pittsburgh Post-Gazette
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The Best Way to Network with Alumni on LinkedIn
September 20, 2012
If you've been feeling the urge lately to buy fresh pencils and open the first page of a crisp new notebook, you're not alone. Whether you graduated two years ago or 20, September always feels like the beginning of a new school year.
For job seekers, this sense of a new beginning can inspire you to inject new energy into your hunt. In particular, the fall season is a nice time of year to reconnect with members of your college or university alumni community, who may be feeling nostalgic for their school days as well (particularly if you have a good football team!).
Here are some tips for connecting and reconnecting with fellow graduates of your alma mater:
1. Join your alumni community. The first essential step is to become a member of your university's alumni group on LinkedIn. Virtually every college and university in the world has one or more, as do many high schools as well. Go to the Groups Directory and search for the name of any educational institutions you attended. You'll find that some schools have multiple groups, so join as many as appeal to you.
Once you're a member, scan the group's Discussions, Members and Jobs for networking opportunities. For instance, join a discussion of fellow alums talking about your industry, comment on an article someone has posted or introduce yourself to the Group Manager, who is often a representative of the Alumni Association (often a very connected and helpful person).
You can also start your own discussion, perhaps posting an article with a few personal comments or posing a question to group members. Or, you can introduce yourself and your goals: "Hi fellow Tigers: I'm new to the group and excited to connect with fellow alums. I'm currently looking for a job as a graphic designer and eager to connect with any other job seekers or design folks. Happy to help anyone I can. Thanks!"
Remember also that LinkedIn permits you to send a message or connection request to anyone with whom you share a group on LinkedIn (as long as that person has opted to accept such messages), which will help you build one-on-one relationships with individual group members.
2. Tap the LinkedIn Alumni tool. Your next stop should be LinkedIn Alumni, a tool that provides you with information about where your fellow alums work, what they do and where they live. The tool pre-fills the years you attended a school listed on your LinkedIn profile and shows you the classmates who attended at the same time. For a broader search, you can enter additional graduation years.
You can look at the big picture of where people work and live, then you can narrow the results according to your goals. Let's say you are looking for a job in public relations at a university or nonprofit organization in the Chicago area. The tool helps you narrow your vast alumni network to those who live in Chicago and work in public relations. Then, you can scan the list of "Where they work" and find the universities and nonprofits where your fellow alums are employed. LinkedIn Alumni will then show you the exact profiles of the alums who fit all of your criteria.
Considering a move to Milwaukee? Just start a new search and click on that region under "Where they live" and all of the data will change to show you fellow alumni in that geographic region instead. If you attended more than one university, you can use the "change school" feature at the top of the page to explore other colleges and universities.
3. Reach Out (the Right Way). Once you've identified some alums in your desired field and location, it's time to make contact. While there are no guarantees, fellow alums are more likely to reply to a networking request than random strangers because you share a common experience. Here is how I would approach an outreach message:
Hi Sonya,
I'm a fellow ABC University alum and came across your profile. I graduated in 2003, also with a degree in History, and have been working in the PR industry for the past few years. I'm currently job hunting and hoping to make the transition from the agency side into a role at a nonprofit or university. I really admire your career and was wondering if you might be willing to offer some advice or perhaps chat by phone? I would really appreciate your time and would be happy to do anything I can to help you.
Thank you and Go Tigers!
Note that the message immediately mentions the alumni connection, is polite and professional and shows that you've done your research on the other person (signifying that you're not just sending out generic blast messages). You never want to sound desperate and you never want to ask directly for a job or to send a resume. The goal here, as with any good networking message, is to establish rapport and ask for general information and advice.
Networking with alumni is an effective and often very enjoyable form of networking for job seekers. Have you had success networking with alumni on LinkedIn? Please share with us on LinkedIn or Twitter!


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Strong, reliable and recyclable, these folded handle bags are available in the following 3 sizes:
180mm x 85mm x 215mm (7" x 10.5" x 8.5")
215mm x 115mm x 255mm (8.5" x 13" x 10")
255mm x 140mm x 305mm (10" x 15.5" x 12")
If you would like your brown flat handle paper bags printed, head over to our printed paper bag section to order.
Need a larger quantity? Email us at firstname.lastname@example.com
All Orders placed on our website are shipped via a third-party carrier.
Free delivery on orders over £100
Please note: orders under £100 will be sent using our standard shipping service, and you will be notified of any shipping fees at time of order. The cost of this service is as follows;
orders up to £20.00 - £5.99
orders from £20.00 to £50.00 - £7.99
orders from £50.00 to £100.00 - £9.99
Orders placed on our website for plain paper bags normally take 2-3 working days to be fulfilled and delivered unless otherwise notified. Orders placed on our website for custom printed paper bags normally take 7-10 working days.
Once orders are shipped, Printonpaperbags is not responsible for lost, stolen, or mis-delivered packages as we use a third-party carrier. The shipping carrier used will be listed on your shipping confirmation email with a link for you to track your packages.
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Once upon a time, not so very long ago, Katherine Heigl was on a popular TV show and was launching a promising film career. She was on the brink of having it all, of being America's next sweetheart and becoming one of the most famous women in the world, with the kind of juice to get whatever projects she wanted made. Then she opened her mouth, and twatness came out. And then it was over.
It took three years for Heigl to blow it, from her breakout in 2007 with Knocked Up, to her unceremonious exit from Grey's Anatomy in 2009, to the double-death knell of Life as We Know It and Killers in 2010. Since then, Heigl is most notable for taking Stephanie Plum behind the woodshed and beating her to death with a box of stale Tastee Cakes. She's only had one movie rate in the double digits on Rotten Tomatoes since 2010: The illustrious The Nut Job, an animated feature which wracked up eleven whole percents on the Tomatometer.
And now Heigl, an actress who was once among the most sought after in Hollywood, is facing the indignity of being unable to finish a movie. Her latest movie, Jenny's Wedding, a rom-com in which a woman surprises her family by announcing that she is marrying another woman, is in post-production and is out of funding. So the producers have turned to Indiegogo, a film-centric crowdfunding platform, to ask for $150,000 to finish the movie. Their pitch states that the needed funds will go to such things as editing, sound mixing, music licensing and original music, and film festival expenses.
I'm skeptical of celebrities using crowdfunding, but I am REALLY skeptical of any movie asking only $150,000 to encompass things like editing and sound mixing. Not having an editor (which Jenny's Wedding doesn't) is concerning, but the sound thing really puts me off. Sound is very expensive—even on small indies it can easily eat up half the budget. Plus they still need music licensing, which ain't cheap either. I've dealt with productions that have nearly been tanked over the issue of song licensing, and that's when everything else is going smoothly, let alone when you don't have the money to do the major parts of post-production.
This is a "flexible" project on Indiegogo, which means the project creators can keep any funds raised even if they don't reach their goal (which seems super shady), so I would like to know, in detail, where my money will go since there is zero chance I will ever get it back, and no guarantee I'll even get to see this movie. How much is being allocated for sound, how much for song licensing, what are the estimated festival expenses? Am I paying for Katherine Heigl's hotel room in Toronto?
After two days, the project has only raised $8200 toward its goal. Once upon a time, Katherine Heigl could snap her fingers and get a movie made. Now she has to beg for scraps.


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"Transparency" gets a few minutes at new ACTA negotiations
By Nate Anderson | Last updated January 26, 2010 2:15 PM
Negotiations on the Anti-Counterfeiting Trade Agreement (ACTA) pick up again today in Guadalajara, Mexico, and run through Friday. The governments who are working on the treaty have long claimed to be interested in "transparency" (despite offering little of it), and this week's negotiating session shows just how important openness has become: discussions on "transparency" get one hour on the final day of the session, and are the last thing on the schedule apart from "other matters" and "press release."
Today is reserved for discussion about ACTA's "civil enforcement" provisions. "Border measures" come up tomorrow. Thursday promises to be interesting, what with its "Enforcement Procedures in the Digital Environment" topic.
Each of these major topics has an entire day of negotiation and discussion, while "transparency" is shoved into Friday's half-day schedule just before everyone jets home. Who knows how much of the hour will even be devoted to the topic, though; the agenda notes that the transparency hour will first feature "continued discussion on previous matters if needed."
Still, at least it's on the agenda. After more than a year of carping by journalists, civil society groups, digital activists, the European Parliament, prominent members of the US government, and even the MPAA, the ACTA nations are at least discussing the issue. Given the late stage of the ACTA negotiations, it's unclear what "transparency" could really mean at this point; negotiators have always expressed a willingness to show the public a draft of the text once it has all been finalized, though this would be far too late to make substantive changes.
If they talk about transparency for too much longer, they might not need to engage in any. Maybe that's the point.
Further reading
[URL=http://www.mfat.govt.nz/Trade-and-Economic-Relations/Trade-Agreements/Anti-Counterfeiting/0-ACTAagendaroundseven.php]* ACTA schedule (mfat.govt.nz)[/URL]
A bit late eh?


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Rule #1 - Be Patient - Rule #2 - Don't ask when, if you don't contribute - Rule #3 - You have coding skills - LinuxMCE's small brother is available: http://www.agocontrol.com
hii am trying to run my mce on this board with a tv attached via s-video.i have no problems running a console, but as soon as x is started the screen stays black.when i boot puppy-linux, sidux or a bart-pe windows everything is fine
i changed the driver setting from 'intel' to 'i810' and now xserver works fine. at least as long as the linuxmce-menu isnt loaded. kde-desktop works, but mce-menu, mce-konfiguration-wizard and av-wizard are not working properly. all i get is flickering. changing resolution and stuff like that didnt help.so far...
pressing 5 (or any other number ^^) has little effect. av-wizards restarts in new resolution and the picture is flickering as before (u can guess what should be on the screen).i tried to make a clean xorg.conf by deleting it and run "dpkg-reconfigure xserver-xorg". but this didnt change a thing.my guess is that the mce-menu/wizard uses a feature, that the normal kde-desktop doesnt use. any tip? =)


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Colorado Springs, Colorado (NAPSI) - Paying it forward can pay off on your next tax return, if you keep track of your donations.
"Giving to charity, even if you're simply donating clothes and furniture to a thrift store, can reduce your taxable income," explained Jessi Dolmage, of the popular digital tax preparation brand TaxACT. "To maximize your deduction, just follow a few simple tips."
• First, be sure you're giving to an eligible organization recognized by the IRS. Search for the group using the IRS' Exempt Organization Select Check at www.irs.gov. Even if it's not listed in the database, most religious organizations and government agencies are eligible.
• Second, keep detailed records for accurate valuation (and, in turn, your tax deduction) and in the unlikely event of an audit. These should include organization name, donation date and amount.
• For noncash donations, document the charity name, date and location of the donation and a reasonably detailed description of the items. If you receive a receipt from the charity, keep it with your records. The IRS requires additional documentation for vehicle donations. You must receive a written acknowledgment or a Form 1098-C from the charity for the vehicle.
• For monetary gifts, keep the written acknowledgment from the organization with the donation date and amount. A canceled check or card statement with the transaction date will do for gifts under $250.
• If you get merchandise, benefits or privileges in exchange for the gift, you must subtract the value of those from the original gift amount. If your payment is more than $75, the organization must give you a written statement with a description and estimated value of the merchandise, goods or services.
• Noncash donations, such as clothing, kitchen gadgets and furniture, must be in good condition or better. The tax-deductible amount of those items is the fair market value (FMV), the price if they were exchanged between willing buyers and sellers. Special rules apply to cars, boats, airplanes, property subject to debt, investments that have appreciated in value, and inventory from your business.
• Mobile apps can make donation tracking easier. For example, TaxACT's free Donation Assistant app tracks cash, noncash and recurring gifts, with FMVs for more than 1,300 commonly donated items. The app can save photos of donations and receipts. Come tax time, the information can be imported into the TaxACT Deluxe program, which calculates the maximum deduction and completes related tax forms.
Charitable gifts made between Jan.1 and Dec. 31 can be deducted if you itemize deductions on Form 1040 Schedule A. To do so, all itemized deductions must exceed the standard deduction amount based on your adjusted gross income and filing status.
Additionally, you must file Form 8283 with your tax return if your cash and noncash contributions total more than $500. You will also need to file a qualified appraisal of donated property worth more than $5,000.
You can download the free app at www.taxact.com/apps and learn more about the tax rules of charitable giving at www.irs.gov and www.taxact.com/taxinfo.


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Notice Number: NOT-MH-07-106
Key Dates
Release Date: February 22, 2007
Issued by
NIH Blueprint for Neuroscience Research (http://neuroscienceblueprint.nih.gov)
National Center for Complementary and Alternative Medicine (NCCAM), (http://www.nccam.nih.gov/)
National Center for Research Resources (NCRR), (http://www.ncrr.nih.gov/)
National Eye Institute (NEI), (http://www.nei.nih.gov/)
National Institute on Aging (NIA), (http://www.nia.nih.gov/)
National Institute on Alcohol Abuse and Alcoholism (NIAAA), (http://www.niaaa.nih.gov/)
National Institute of Biomedical Imaging and Bioengineering (NIBIB), (http://www.nibib.nih.gov/)
National Institute of Child Health and Human Development (NICHD), (http://www.nichd.nih.gov/)
National Institute on Drug Abuse (NIDA), (http://www.nida.nih.gov/)
National Institute on Deafness and Other Communication Disorders (NIDCD), (http://www.nidcd.nih.gov/)
National Institute of Dental and Craniofacial Research (NIDCR), (http://www.nidcr.nih.gov/)
National Institute of Environmental Health Sciences (NIEHS), (http://www.niehs.nih.gov/)
National Institute of General Medical Sciences (NIGMS), (http://www.nigms.nih.gov/)
National Institute of Mental Health (NIMH), (http://www.nimh.nih.gov/)
National Institute of Neurological Disorders and Stroke (NINDS), (http://www.ninds.nih.gov/)
National Institute of Nursing Research (NINR), (http://ninr.nih.gov/ninr/)
Office of Behavioral and Social Sciences Research (OBSSR), (http://obssr.od.nih.gov/)
This is a time-sensitive RFI directed toward determining how best to accelerate research in neuronal plasticity. Responses to this RFI should be pertinent to the interests of one or more of the NIH Neuroscience Blueprint Institutes listed above. Comments pertaining to normal and/or abnormal plasticity within the nervous system are encouraged.
Neuroscience research is a unifying theme across many NIH Institutes and Centers. The NIH Blueprint for Neuroscience Research was launched in 2004 with 16 participating Institutes and Centers to provide a framework for coordinating research, and for developing tools and resources which are broadly useful for advancing neuroscience research (http://neuroscienceblueprint.nih.gov/). To this end, the NIH is generating a series of focused initiatives designed to catalyze neuroscience research. In fiscal years 2005 and 2006, the Blueprint supported the creation and distribution of resources that are of broad utility to the entire neuroscience community. In fiscal years 2007-2009 the NIH Blueprint plans to address three specific, cross-cutting themes: neurodegeneration, neurodevelopment, and neuronal plasticity, respectively.
NIH Blueprint Resources Currently Available to the Neuroscience Community
The goal of the NIH Blueprint is to create research tools, resources and infrastructure that will better serve the neuroscience community. This is accomplished by pooling resources and expertise, and by taking advantage of economies of scale, to confront challenges too large for any single NIH Institute or Center. The NIH Blueprint is presently in its third year and a variety of tools and resources are becoming available to the neuroscience community through its activities. The following websites provide overviews of the NIH Blueprint initiatives already underway, many of which are useful to researchers studying neuronal plasticity:
Information Requested
Any aspect of nervous system plasticity is of interest to the NIH Neuroscience Blueprint. The study of neuronal plasticity encompasses many levels of analysis, including genetic, molecular, cellular, integrative, behavioral, computational, and clinical research. The goal of this RFI is to identify the need for new or adapted tools and resources to enhance and facilitate the study of neuronal plasticity. As part of the initial planning process for blueprint activities related to neuronal plasticity, the participating NIH Institutes and Centers request responses to the questions below:
The NIH Blueprint goal for fiscal year 2009 is to generate novel research tools and resources to rapidly advance the field of neuronal plasticity. The Blueprint represents a unique means to enhance cooperative activities among the fifteen NIH Institutes and Centers that support research on the nervous system. To that end, the Blueprint encourages visionary ideas that will dramatically stimulate the field of neuroscience.
Please send responses to email@example.com no later than April 15, 2007
Specific questions about this Notice may be directed to:
Nancy Pilotte, Ph.D., Chief
Functional Neuroscience Research Branch
National Institute on Drug Abuse
6001 Executive Blvd., Rm 4282, MSC 9555
Bethesda, MD 20892-9555
Tel: 301-435-1317
Email: email@example.com
Chiiko Asanuma, Ph.D.
Signal Transduction Program
National Institute of Mental Health
6001 Executive Blvd., Rm. 7183, MSC 9605
Bethesda, MD 20892-9605
Tel: 301-443-5288
Email: firstname.lastname@example.com
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
Office of Extramural
Research (OER)
National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
Department of Health
and Human Services (HHS)
Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.


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A nice and happy positive theme, with acoustic guitars, banjos, violins and finger snaps, useful for backgrounds, presentations, family slideshows.
Thanks for listening
Feel free to contact us for any custom edit
check also our acoustic pack:
A gentle and calm pack, with acoustic guitars and pianos, perfect for every background.
In the pack you'll find both wav and mp3 of the following themes.
Plus you get the last one backing track (no guitar solo).
http://audiojungle.net/item/acoustic-corp/3973411 (03:32)
http://audiojungle.net/item/acoustic-peace/4118720 (04:02)
http://audiojungle.net/item/positive-acoustic/4075897 (03:20)
http://audiojungle.net/item/acoustic-dreams/2249919 (02:39)
This item is featured in:


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Tuesday, March 27, 2012
1984 - Anatomy of a cover - Marvel Team-Up #141
6 comments:
Hey, that's cool!! Do you know if this unfinished version was also inked by Mignola? Where did you find it?ReplyDelete
Sorry, I searched through my notes and my usual sources like romitaman or heritage auctions, but couldn't find where I grabbed it from. Sorry.ReplyDelete
Ha! Found it this morning:ReplyDelete
The alternate version is cool, but I can see why they went with the one that saw print. After all, that new costume was being used as a selling point for the book, and the alternate version has Spidey blocking much of the central white spider emblem with his left arm.ReplyDelete
Thanks, Jason!! If you don't mind, I'll also post it in my blog. This is a great rarity!ReplyDelete
Please go ahead! It is quite a rarity, especially with the fact that it was drawn on the back of the Web of Spider-Man pinup...ReplyDelete


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Give in to the EA Sports UFC Submission Video
When EA Sports acquired the license for UFC, it aimed to create a more accurate MMA experience than in any previous game. In addition to a new artificial intelligence system that makes fighters react more realistically and full-body deformations that add visual authenticity, they reinvented many of the core fighting mechanics. A gameplay trailer for EA Sports UFC released today shows off the new submission system.
THQ's last UFC game, UFC Undisputed 3, handled submission moves by making one player chase the other player's cursor around an octagonal track to break out of a hold. EA has kept the octagon shape, but changed everything else, improving the system dramatically. Players now decide submissions in a unique four-sided tug of war system that challenges the defender to respond to on-screen cues with the correct direction on the right analog stick quicker than the aggressor to free themselves. The attacker must do the same, but also needs to be on the lookout for additional prompts that allow him to enter the next stage of the submission hold with a proper response on the left stick.
In addition to the submission lesson, this trailer also gives us our first look at a match-up in the Women's Bantamweight division, featuring Ronda Rousey and Miesha Tate. Five more women, and approximately 100 fighters total, will make up the EA UFC roster when the game is released on June 17 for the Xbox One and PlayStation 4.


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Historic Milford Association
There was no other place for RRT to start their story; Milford was to be our home without question. Owners Joe and Emily are Milford residents, Joe being born and raised here. Nature Outfitters, which was our predecessor, had a home here for about 20 years before us. The downtown area is special, hosting unique shops, unique restaurants, and a very unique position as a trail junction. We wanted to have a positive impact on the city and its economic development and also on its image and reputation across the tri-state.
The Historic Milford Association is a not-for-profit that helps the small businesses in Historic Milford unite and showcase themselves. The association fights to protect business owners' interests and allows for a stronger singular voice as a collective. HMA focuses on marketing the downtown, including several festivals over the years and events every year like Hometown Holidays
Both Emily and Bryan have held several board positions since becoming members in 2010. Emily role has included acting as the Longstone festival chair for both 2013 and 2014. Emily then moved to the position of treasurer through 2017. Today, Emily helps push social media and website content. All of these responsibilities are of course done as an unpaid volunteer to benefit the city in which we operate. In 2016 RRT was officially recognized by the Milford Miami Chamber of Commerce with an award for outstanding achievement within the community in "Environment and Education".
Together with HMA we hope to continue to build the historic area of Milford to be an ever-growing and beautiful place to eat, shop, and play. For more information on the Historic Milford Association, please visit the HMA website below. For more information on the "Trail Junction" and Milford as a trail town please read the RRT blog by clicking the link below.
Read "The Best Trail Town" Blog


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The doll in the photo is 161cm (5FT2), the entire body TPE material💖The material is made of safe and non-toxic medical silicone (TPE), which is soft to the touch and feels almost the same as real people.💖The hinged metal alloy frame at the core allows her to pose as a real woman in any position.💖All TPE sex dolls have 3 holes (anus, vagina, mouth) and silicone doll have 2 holes (anus, vagina) to bring you the ultimate sexual pleasure.💖Guaranteed privacy. Your privacy is very important to us. Our discreet packaging allows you to shop with confidence.💖Safety certificate - Each sex doll is made of medical-grade TPE. Conforms or exceeds the safety requirements of ASTM F963 and EN71, which is safe for contact with human skin.
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Maldicion Gitana
by Andres Vadin, Carlos EStevez, Julio Montoro, Luis Alberto Vicet Vives(La Crema), Tomezclao and Yusi Gonzalez
An uptempo Flamenco instrumental with breaks in-between. Along with its Spanish origins, Gypsy, Byzantine, Sephardic and Moorish elements have often been cited as influences in the development of flamenco. Also available in tropical and salsa.
Latin Quarter I: Argentina, México, Spain: Mariachi, Norteño, Tango, Flamenco & Banda
Welcome to the Latin quarter where you will find music from all corners of Latin America. This compilation is part of a series from 1 to 10 containing Music from Mexico, Argentina, Spain and other Latin American countries.
Artist: Compilation
Flamenco is a genre of Spanish music, song, and dance from Andalusia, in southern Spain, that includes cante (singing), toque (guitar playing), baile(dance) and palmas (handclaps). First mentioned in literature in 1774, the genre grew out of Andalusian and Romani music and dance styles. Different Fl more
Artist: Andres Vadin
Featured Artist
Cajon Flamenco
The best thing to come out of Cuba in recent times! So asserts Tumi label boss Mo Fini, who waxes long and rapturous about this indisputably vibrant collective in the accompanying DVD. And the Havana-based To'Mezclao are indeed very good: a seven-strong crew of music enthusiasts whose versatility (a more


text: Recently, a sinkhole developed outside of Leadville, Colorado. While this photo shows a deep mine and is not connected to the sinkhole outside of Leadville, you may wonder, what other strange or weird holes lie beneath the wonderful mountains and plains of Colorado? For more information about today's Weird Photo Wednesday, click here. For more weird and strange photographs, check out our Digital Collections.


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Dirtring is a checkpoint side-mission in Grand Theft Auto: Vice City, one of the three events that takes place at Hyman Memorial Stadium.
The premise of Dirtring is for the player to reach a total of 32 checkpoints scattered around an arena-sized area containing ramps, wrecks, walls, and a dirt track using a Sanchez dirt bike; many of the checkpoints are located at places typically hard to reach using a motorbike, requiring the player perform stunts (loop-the-loops and jumps over wrecks or rings of fire) or ride along thin ledges or planks to reach a checkpoint in an elevated position. These rings of fire have no effect on the player or their vehicle whatsoever.
Because there is no time limit (although the player's run is timed), the player may choose to complete the side-mission at their own pace; completion of the side-mission at any time is essential for completion. If the player is dismounted from their bike, the player has 30 seconds to return to it, or the player fails the side-mission; the player may also walk to a halo in the middle of the course to end the side-quest.
If the player succeeds in reach all checkpoints in 4 minutes and 30 seconds, the player will be awarded $50,000. Otherwise, the player will simply be rewarded $10,000.
There is one known glitch with the mission in that if you park close enough to the Hyman door that you are drawn into the mission by getting out, if you push the enter vehicle button right after getting out and activating the mission; you will begin to get into your vehicle again and you will appear in the mission inside the vehicle you had outside.
Video walkthrough
|PC Version - GTASeriesVideos
See also
- Dirt Track and Kickstart, both of which fall under the "Dirtring" name in GTA San Andreas.


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Release Date: May 31, 2011
Publisher: HarperTeen
Pages: 496
Received: ARC through blog tour
Rating: 4 out of 5 stars
Goodreads Page
From Goodreads:
How do you defy destiny?
Helen Hamilton has spent her entire sixteen years trying to hide how different she is—no easy task on an island as small and sheltered as Nantucket. And it's getting harder. Nightmares of a desperate desert journey have Helen waking parched, only to find her sheets damaged by dirt and dust. At school she's haunted by hallucinations of three women weeping tears of blood . . . and when Helen first crosses paths with Lucas Delos, she has no way of knowing they're destined to play the leading roles in a tragedy the Fates insist on repeating throughout history.
As Helen unlocks the secrets of her ancestry, she realizes that some myths are more than just legend. But even demigod powers might not be enough to defy the forces that are both drawing her and Lucas together—and trying to tear them apart.
I've read some...not very nice reviews about this book. Is there a lot to complain about? Yeah, I guess. The two main complaints I've heard is that a lot of the basics are reminiscent of Twilight and the writing isn't flawless. Ok, I can see that to an extent.
Except, I don't care. I was wrapped up in the book and I finished this gigantic near-500 page tome in just three days. For me, this was one of those books that I just wanted to read. Whenever I wasn't reading it, I was thinking about it. When I was reading it, the world disappeared. By the end of those near-500 pages all I wanted was 500 more!
The only thing that did give me pause was the narration style. Most of the book is told in the third person with a subjective focus on Helen, but every rare once in a while the view shifts for a scene or two to another character. This almost always happened when Helen wasn't present, so I get why the author did it, but it did feel a little bit like "one of these things doesn't belong." I'm not really sure what the solution would be (maybe include more chapters from other characters' points of view so it doesn't stand out and feel so random?), but something should be done with that.
There was also some room for improvement with the pacing. Objectively, I think Starcrossed was hit with a major case of Twilight Pacing Syndrome and should have been more tightly edited. There's a huge info-dump toward the end that can be a little overwhelming. Still, as with when I read Cynthia Hand's Unearthly, I wasn't really bothered. I liked the characters and even if they weren't doing much, I was still content to follow along with whatever it was they were doing.
What started out as MEGA insta-hate rapidly turned into insta-love. Unlike most YA insta-love books, at least we're given an explanation for their quick feelings...sort of. I'll buy it and go with it for now to see where Josie takes things, but it's still just a little *too* insta-love for my tastes. Circumstances keep our star-crossed lovers separated for most of the book though, so at least I wasn't bored with extended soul-gazing scenes. Plus, no love triangle in sight, so yay for that!
As far as Helen and Lucas go, I like Helen and I'm cool with Lucas. Helen is the girl who didn't know she was special, but now realizes she's super-girl. Helen is almost a Mary Sue, but what saves her is how "normal girl" she is. She reminded me a lot of Clara from Unearthly. Yes, she's special, but at the end of the day she's a teenage girl with all of the insecurities, hopes, and fears that normal teenage girls have. I would invite her to my sleepover party. Plus, she's not weak and useless, so major points for saving me from that annoying plot device.
Lucas is nice and I'm very happy for Helen because he seems like a great catch, but I'm not jealous. She can have him. I want Hector (Lucas's cousin and NOT a romantic interest for Helen. He's more cocky alpha male). Don't get me wrong though, Lucas is totally swoon-worthy in both looks and personality.
Yes, there are numerous Twilight similarities here and I know I'll be handing a copy of Starcrossed to all my library people who loved Twilight. But so what if there are similarities? It's a totally different story and I think even people who disliked Twilight could get on board with Starcrossed (Helen is like the anti-Bella and Lucas isn't weird). There were two things I really liked about Twilight, and those two things are present here: Family and history.
I absolutely loved the big family feeling we got from the Cullens in Twilight, and we get that same feeling here with the Delos clan. I don't care if I'm reading scenes about the Delos clan ordering a pizza or some other mundane and otherwise boring event. I just want to vicariously be a part of their family.
The history in Starcrossed takes its inspiration from Greek mythology, but Josephine Angelini really made it her own. Yes, I'm sure Greek myth sticklers will have a field day with this, but whatever. Bottom line is, Josephine Angelini has created an epic story with likable characters, an engrossing history, edge of your seat fights, star-crossed love, and super high stakes. I thought it was pretty awesome.
Enough of the history is explained here that I feel grounded and satisfied, but there's still so much more yet to uncover. The peeling back of these layers and learning all about the history really kept me turning the pages. Josephine Angelini sweetens the pot even more by adding a few really duplicitous characters. Not only do you have a ton of history, but unraveling it all is complicated by the lies spun by these sly characters. The final 1/4 had me at the edge of my seat and gasping at what was going on. I cannot wait for the next book to come out so I can find out more!
The bane of YA books: The CLIFFHANGER!!! Yep, it's here. I tried making notes, but even writing down the family tree was a complicated mess with a bizillion annotations and asides (I'm in heaven!). A TON of stuff happens here, and it's all twisty like a soap opera. I'm so going to have to reread Starcrossed before I read book 2 if I want to understand anything. But I will SO DO THAT because I am 100% definitely and with no reservations going to be continuing on with this series (Book 2: Dreamless, published sometime in 2012).
Explanation of rating system: Star Rating Key
Feel free to ask in the comments!
If Starcrossed sounds like a book you might enjoy, then be sure to stop by on Wednesday when I post up my part of Lucas's letter to Helen as part of the blog tour!
Check out the previous stops HERE.
Not only will you get a chance to win Starcrossed, but you can also enter for a chance to win a Kindle 3WiFi, a personalized letter from the author, and a Gelaskin of Starcrossed's cover art!
Looking for another book like this?


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Bacterial urinary tract infections (UTIs) typically result from normal skin and GI tract flora ascending the urinary tract and overcoming the normal urinary tract defenses that prevent colonization. Bacterial UTI is the most common infectious disease of dogs, affecting 14% of all dogs during their lifetime. Although UTIs are uncommon in young cats, the incidence of UTI is much higher in older cats, which may be more susceptible to infection because of diminished host defenses secondary to aging or concomitant disease (such as diabetes mellitus, renal failure, or hyperthyroidism). Approximately two-thirds of those cats also have some degree of renal failure. Bacterial UTIs in ruminants are associated with catheterization or parturition in females and as both a cause and consequence of urolithiasis in males. In horses, UTIs are uncommon and typically associated with bladder paralysis, urolithiasis, or urethral damage.
Unlike human patients, veterinary patients are often asymptomatic, and the UTI may be an incidental finding. The consequences of untreated UTI include lower urinary tract dysfunction, urolithiasis, prostatitis, infertility, septicemia, and pyelonephritis with scarring and eventual kidney failure. Coagulase-positive staphylococci are involved in the formation of struvite (MgNH4PO4) calculi in dogs. In intact male dogs, UTI frequently extends to the prostate gland. Because of the blood-prostate barrier, it is difficult to eradicate bacteria from the prostate, and the urinary tract may be reinfected after appropriate treatment, causing a systemic bacteremia, infecting the rest of the reproductive tract, or causing an abscess within the prostate.
Large, retrospective studies have documented the most common species of uropathogens in dogs and cats, with Escherichia coli being the single most common pathogen in both acute and recurrent UTIs. The other common pathogens include Staphylococcus, Proteus, Streptococcus, Klebsiella, and Pseudomonas spp. In UTIs in horses, E coli, Streptococcus, and Enterococcus spp predominate, whereas Corynebacterium renale and E coli are the most common pathogens in ruminants. In immunocompromised animals, funguria from Candida spp may occur.
Antimicrobials are the cornerstone of UTI therapy, and many animals with recurring UTIs are managed empirically with repeated courses ( see Table: Drugs Commonly Used to Treat Urinary Tract Infections in Small Animals Drugs Commonly Used to Treat Urinary Tract Infections in Small Animals ). This approach fails if the underlying pathophysiology predisposing the animal to the UTI is not addressed; as well, it encourages emergence of resistant bacteria. With chronic UTI from highly resistant bacteria, therapeutic options are extremely limited.
Antimicrobial Therapy:
Urine culture is the "gold standard" for diagnosis of UTI. Indications to perform urine culture include visualization of bacteria during urine sediment examination, evidence of pyuria, dilute urine (<1.013 SG), immunosuppression, and diabetes mellitus or hyperadrenocorticism. Antimicrobial susceptibility testing should be done with complicated or recurrent cases of UTIs, immunosuppressed animals, animals recently catheterized, or animals treated with antimicrobials within the preceding 3 wk (because of selection for antimicrobial resistance). In addition, culture and susceptibility testing should be performed in cases that do not respond within 7 days of therapy for UTI or in cases associated with multiple pathogens.
High urine concentrations of antimicrobials are correlated with efficacy in treatment of uncomplicated cystitis. But in complicated cases and in pyelonephritis, tissue concentrations may be equally important. Most antimicrobials undergo renal elimination to a great extent, so urine concentrations may be up to 100 times peak plasma concentrations. Drug excretion through the kidney involves various processes such as secretion and/or reabsorption in different parts of the nephron, depending on the molecular structure of the drug, its pKa, the pH in the tubular fluid, and degree of protein binding. The flow of urine through the urinary tract is part of the defense against invading pathogens, because the flow of fluid rinses the epithelial linings. High urine antimicrobial concentrations are important for eradication of bacteria in the urine, but for infection of the bladder wall or renal tissue it is necessary to use antimicrobials that have active concentrations in the tissues. Serum or plasma concentrations are useful surrogate markers for antimicrobial concentrations in the renal or bladder tissues.
In addition to having the appropriate antimicrobial activity and achieving effective concentrations in urine, the selected antimicrobial should be easy for owners to administer, have few adverse effects, and be relatively inexpensive. Once urine culture and sensitivity results are known, the bacterial minimum inhibitory concentration (MIC) can be compared with the mean urinary concentration of the drug and an appropriate antimicrobial chosen.
Amoxicillin and ampicillin are bactericidal and relatively nontoxic, with a spectrum of antibacterial activity greater than that of penicillin G. They have excellent activity against staphylococci, streptococci, enterococci, and Proteus, and may achieve urinary concentrations high enough to be effective against E coli and Klebsiella. Pseudomonas and Enterobacter are resistant. Amoxicillin is more bioavailable in dogs and cats (better absorbed from the GI tract) than ampicillin, hence the lower dosage. Absorption of ampicillin is also affected by feeding, so therapeutic success may be easier to achieve with amoxicillin. As penicillins, they are weak acids with a low volume of distribution, so they do not achieve therapeutic concentrations in prostatic fluid.
Amoxicillin-clavulanic acid has an increased spectrum of activity against gram-negative bacteria because of the presence of clavulanic acid. Clavulanic acid irreversibly binds to β-lactamases, allowing the amoxicillin fraction to interact with the bacterial pathogen. This combination usually has excellent bactericidal activity against β-lactamase–producing staphylococci, E coli, and Klebsiella. Pseudomonas and Enterobacter remain resistant. However, clavulanic acid undergoes some hepatic metabolism and excretion, so much of the antimicrobial activity in the bladder may be due to the high concentrations of amoxicillin achieved in urine. Thus, despite an unfavorable susceptibility report for amoxicillin, clinically amoxicillin alone may be as effective as amoxicillin-clavulanic acid to treat UTIs.
Cefadroxil and cephalexin are first-generation cephalosporins. Cefadroxil is a veterinary-labeled suspension product, whereas cephalexin is available in both human and veterinary formulations as tablets, paste, or suspension products. Like the penicillins, they are bactericidal, acidic drugs with a low volume of distribution and are relatively nontoxic. Vomiting and other GI signs may occur in dogs and cats treated with cephalosporins. Cephalosporins have greater stability to β-lactamases than penicillins, so they have greater activity against staphylococci and gram-negative bacteria. They have excellent activity against Staphylococcus spp, Streptococcus spp, E coli, Proteus, and Klebsiella. Pseudomonas, enterococci, and Enterobacter are resistant.
Cefovecin is an injectable, third-generation cephalosporin approved for treatment of dogs with a UTI due to E coli or Proteus. In cats, it is only approved for skin infections but may be used in an extra-label manner for UTIs. With SC dosing, therapeutic concentrations are achieved for 14 days, making this an attractive treatment choice for fractious animals.
Cefpodoxime is an oral, third-generation cephalosporin approved for use in dogs for skin infections (wounds and abscesses), but it is used extra-label for treatment of canine UTI. Cefpodoxime has a relatively long half-life in dogs, so it is dosed once daily.
Ceftiofur is an injectable cephalosporin approved for respiratory disease in horses, swine, and cattle and for treatment of canine UTI caused by E coli and Proteus. Ceftiofur has pharmacokinetic properties very different from those of other cephalosporins. After injection, ceftiofur is immediately metabolized to desfuroylceftiofur, which has different antimicrobial activity than the parent compound. Desfuroylceftiofur has equivalent activity to ceftiofur against E coli (MIC 4 mcg/mL) but is much less active against Staphylococcus spp and has variable activity against Proteus (MIC 0.5–16 mcg/mL). Because of the instability of desfuroylceftiofur, microbiology services use a ceftiofur disk when performing susceptibility testing, so a false expectation of therapeutic efficacy may result for some pathogens. Pseudomonas, enterococci, and Enterobacter spp are resistant to ceftiofur and desfuroylceftiofur. Ceftiofur is associated with a duration- and dose-related thrombocytopenia and anemia in dogs, which would not be expected with the recommended dosage regimen.
Chloramphenicol has a high volume of distribution, and high tissue concentrations can be achieved, including in the prostate of male dogs and cats. It is active against a wide range of gram-positive and many gram-negative bacteria, against which it is usually bacteriostatic. Chloramphenicol is typically active against enterococci, staphylococci, streptococci, E coli, Klebsiella, and Proteus. Pseudomonas are resistant. North American isolates of methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius are typically susceptible. Well known for causing idiosyncratic (non-dose-dependent) anemia in people and dose-dependent bone marrow suppression in animals, its use in both human and veterinary medicine is increasing because of resistance to other antimicrobial drugs.
Enrofloxacin, orbifloxacin, and marbofloxacin are all fluoroquinolones approved to treat UTIs in dogs; although all are used in cats, only some are approved for this use. Pradofloxacin is only approved for skin infections in cats in North America, but it is approved for treatment of UTI in dogs in Europe and is used to treat feline UTI. The fluoroquinolones are bactericidal, amphoteric drugs. They possess acidic and basic properties but are very lipid soluble at physiologic pH (pH 6–8) and thus have a high volume of distribution. All fluoroquinolones usually have excellent activity against staphylococci and gram-negative bacteria, but they may have variable activity against streptococci and enterococci. The therapeutic advantages of these drugs are their gram-negative antimicrobial activity and high degree of lipid solubility. They are the only orally administered antimicrobials effective against Pseudomonas. Therefore, fluoroquinolones should be reserved for UTIs that involve gram-negative bacteria, especially Pseudomonas, and for UTIs in intact male dogs and cats because of their excellent penetration into the prostate gland and activity in abscesses. They are concentration-dependent killers with a long postadministration effect, so once daily, high-dose therapy for a relatively short duration of treatment is effective.
Fluoroquinolones should be avoided for chronic, low-dose therapy, because this encourages emergence of resistant bacteria that are cross-resistant to other antimicrobial drugs as well. Cases that involve Pseudomonas should be carefully investigated for underlying pathology, which must corrected if at all possible. Once Pseudomonas spp become resistant to the fluoroquinolones, there are no other convenient therapeutic options.
Gentamicin and the other aminoglycosides are very large, polar (water-soluble) molecules, so they have a low volume of distribution and do not penetrate the blood-prostate barrier. They are not absorbed orally and must be given by SC, IM, or IV injection. The aminoglycosides have a similar spectrum of activity to that of the fluoroquinolones, but their use for UTI is limited because of the necessity of parenteral injections and the risk of toxicity with anything but short-term use. Like the fluoroquinolones, the aminoglycosides are concentration dependent, bactericidal killers with a long postadministration effect, so once-daily therapy of short duration is effective and minimizes the risk of nephrotoxicity. They can be considered for in-hospital or outpatient treatment of UTI due to fluoroquinolone-resistant pathogens; however, the importance of identifying and correcting underlying pathology must be emphasized.
Nitrofurantoin is a human product available as tablets, capsules, and a pediatric suspension. It is not commonly used in veterinary medicine. It is typically used only for treatment of UTI in people, because it has a very low volume of distribution, and therapeutic concentrations are attained only in urine. It is considered a carcinogen, so it is banned for use in food-producing animals, but its use in small animals is increasing with the rising rates of antimicrobial resistance to veterinary antimicrobials. Nitrofurantoin is used for infections caused by E coli, enterococci, staphylococci, Klebsiella spp, and Enterobacter spp. It is increasingly indicated for treatment of UTIs caused by multidrug-resistant bacteria, which are otherwise difficult to treat using conventional veterinary antimicrobial agents. The pharmacokinetics and adverse effect profile of nitrofurantoin have not been investigated in dogs, cats, or horses, and the need for multiple daily dosing makes it inconvenient for owners.
Tetracyclines are bacteriostatic, amphoteric drugs with a high volume of distribution. Tetracyclines are broad-spectrum antimicrobials, but because of plasmid-mediated resistance, susceptibility is variable in staphylococci, enterococci, Enterobacter, E coli, Klebsiella, and Proteus. In most tissues, Pseudomonas spp are resistant. However, the tetracyclines are excreted unchanged in urine, so high urinary concentrations may result in therapeutic efficacy. Doxycycline is a very lipid-soluble tetracycline better tolerated in cats and reaches therapeutic concentrations in the prostate, so it may be useful for some UTIs. Doxycycline may also be effective to treat methicillin-resistant staphylococcal UTIs. If capsules are administered, it is critical to have the animal drink afterward to ensure passage into the stomach. If capsules remain in the esophagus, severe local necrosis with subsequent esophageal stricture can occur.
Trimethoprim-sulfonamides (TMP-sulfas) are combinations of two very different drugs that act synergistically on different steps in the bacterial folic acid pathway. Trimethoprim is a bacteriostatic, basic drug with a high volume of distribution and a short elimination half-life, whereas the sulfonamides are bacteriostatic, acidic drugs with a medium volume of distribution and long half-lives (ranging from 6 to >24 hr). These drugs are formulated in a 1:5 ratio of TMP to sulfa, although the optimal bactericidal concentration is a ratio of 1:20 TMP:sulfa. Microbiology services use the 1:20 ratio in susceptibility testing; however, the widely varying pharmacokinetic properties of this drug combination make it difficult to determine a therapeutic regimen that achieves the 1:20 ratio at the infection site. Although the combination does penetrate the blood-prostate barrier, sulfa drugs are ineffective in purulent material because of freely available para-aminobenzoic acid from dead neutrophils. The combination of TMP-sulfa is synergistic and bactericidal against staphylococci, streptococci, E coli, and Proteus. Activity against enterococci and Klebsiella is variable, and Pseudomonas is resistant. TMP-sulfas are associated with a number of adverse effects, and chronic low-dose therapy may result in bone marrow suppression and keratoconjunctivitis sicca in dogs.
Dosage Regimens for UTI:
Currently, the duration of therapy for UTI is controversial. Although animals are routinely treated with antimicrobial drugs for 10–14 days, shorter duration antimicrobial regimens are routinely prescribed in human patients, including single-dose fluoroquinolone therapy. A clinical comparison of 3 days of therapy with a once-daily high dose of enrofloxacin with 2 wk of twice daily amoxicillin-clavulanic acid showed equivalence in the treatment of simple UTI in dogs. However, further studies are needed to determine the optimal dosage regimens for different classes of antimicrobials, and it is inappropriate to use fluoroquinolones as first-line therapy for simple UTIs. Animals with complicated UTI may require longer courses of therapy, and underlying pathology must be addressed. Chronic complicated cases of UTI, pyelonephritis, and prostatitis may require antimicrobial treatment for 4–6 wk, with the risk of selecting for antimicrobial resistance. A follow-up urine culture should be performed after 4–7 days of therapy to determine efficacy. If the same or a different pathogen is seen, then an alternative therapy should be chosen and the culture repeated again after 4–7 days. Urine should also be cultured 7–10 days after completing antimicrobial therapy to determine whether the UTI has resolved or recurred.
Managing Multiple Episodes of UTI:
In dogs and cats, if UTI occurs only once or twice yearly, each episode may be treated as an acute, uncomplicated UTI. If episodes occur more often, and predisposing causes of UTI cannot be identified or corrected, chronic low-dose therapy may be necessary. Low antimicrobial concentrations in the urine may interfere with fimbriae production by some pathogens and prevent their adhesion to the uroepithelium. In dogs, recurrent UTIs are due to a different strain or species of bacteria ~80% of the time; therefore, antimicrobial culture and susceptibility is still indicated. Antimicrobial therapy should be started as previously described and when urine culture is negative, continued daily at ⅓ the total daily dose. The antimicrobial should be administered last thing at night to ensure that the bladder contains urine with a high antimicrobial concentration for as long as possible.
Appropriate antimicrobials for chronic, low-dose therapy include amoxicillin, ampicillin, amoxicillin-clavulanic acid, doxycycline, cephalexin, cefadroxil, and nitrofurantoin. A trimethoprim-sulfonamide can be used, but folate supplementation should be provided (15 mg/kg, bid) to prevent bone marrow suppression; there is also the risk of keratoconjunctivitis sicca developing with longterm use. Although attractive for owner convenience, third-generation cephalosporins such as cefpodoxime and cefovecin and fluoroquinolones should not be used for longterm therapy. During longterm therapy, urine culture should be repeated every 4–6 wk. As long as the culture is negative, therapy is continued for 6 mo. If bacteriuria occurs, the infection is treated as an acute episode with an appropriate antimicrobial. After 6 mo of bacteria-free urine, the longterm, low-dose antimicrobial therapy may be discontinued, and many animals will not have additional recurrences. In some cases, longterm therapy may be continued for years in animals that continue to have recurrent UTIs.
Therapeutic Failures:
Treatment failures may be due to poor owner compliance, inappropriate choice of antimicrobials, inappropriate dose or duration of treatment, antimicrobial resistance, superinfection, or an underlying predisposing cause (eg, urolithiasis, neoplasia, urachal diverticula). If treatment for a simple or complicated UTI fails, a thorough evaluation should be performed to determine and, when possible, address the cause of failure. When faced with a therapeutic failure, the practitioner must consider whether the UTI is due to a relapse or a reinfection. Relapses due to infection by uropathogens with enhanced intrinsic virulence occur with what should be effective antimicrobial therapy. Strains of uropathogenic E coli have a number of virulence mechanisms that enable them to invade, survive, and multiply within the uroepithelium. The sequestration of uropathogenic E coli within the bladder uroepithelium presents a great therapeutic challenge in both human and veterinary patients. There is no clear consensus in the human medical literature about how to approach these recurrent and persistent UTIs.
Antimicrobial Resistance in Uropathogens:
Acquired resistance to antimicrobials by uropathogens is of great concern in both human and veterinary medicine. The prevalence of multidrug resistance in uropathogens is increasing, particularly in infections in dogs and cats. Extended-spectrum β-lactamase genes are increasingly identified in E coli isolates from companion animals. Increases in the occurrence of fluoroquionolone-resistant E coli in dogs have been widely reported. Because the mechanism of resistance to fluoroquinolones frequently involves efflux pumps, it also conveys multidrug resistance. Fluoroquinolone resistance is also increasing in other uropathogens, including enterococci, Proteus mirabilis, and Staphylococcus pseudintermedius isolates. Methicillin-resistant staphylococci have been identified in cases of canine UTI. There is increasing evidence that animals are an important reservoir of antimicrobial-resistant bacteria causing infections in people. Enterococci isolated from canine UTIs have been associated with several different resistant phenotypes, with most exhibiting resistance to three or more antimicrobials. One Enterococcus faecium isolate displayed high-level resistance to vancomycin and gentamicin. Sequence analysis suggested that resistance was due to gene exchange between human and canine enterococci. The use of "last resort" human antimicrobials in veterinary patients with resistant infections is controversial. Vancomycin, imipenem-cilastatin, meropenem, fosfomycin, quinupristin-dalfopristin, and tigecycline should not be used routinely in treatment of UTI in animals. Nonantimicrobial control of infection should be considered whenever feasible. Custom-made vaccines, cranberry juice/extract, probiotics and adherence/colonization inhibitors, and establishment of asymptomatic bacteriuria may help preserve the efficacy of antimicrobials.


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Pushing Boundaries to Co-Create a Higher Quality of Life
GGB, formerly Glacier Garlock Bearings, has the tribological, material science, and applications expertise to provide innovative solutions to even the most challenging requirements, either with standard offerings or with customized products developed in collaboration with its customers. The company also provides local applications engineering and technical support to assure the performance, reliability, and cost-effectiveness of its products.
GGB offers the industry's most extensive portfolio of self-lubricating and prelubricated bearings in a variety of configurations and materials, including metal-polymer, solid polymer, filament wound and metallic. Also offered are bushing blocks for fluid power applications, a complementary range of specialized housings and assemblies, and fluid film bearings for high-load, high-speed applications. These products are used in literally thousands of applications in hundreds of industries, where they offer users The GGB Advantage:
Among the industries using GGB bearings is automotive with more than 50 applications per vehicle. In these applications the bearings' absence of moving parts and low friction reduce noise, improve fuel consumption and provide smooth, reliable operation. The company's bearings are also used by the aerospace industry where their light weight helps reduce fuel costs, as well as in fluid power applications where their compatibility with hydraulic fluids and seizure resistance under low speeds make them ideal for use in gear and piston pumps.
In addition, GGB bearings can be found in compressors where their self-lubricating properties offer superior reliability with low viscosity lubricants, and in construction and other off-highway equipment requiring low maintenance and grease-free operation under severe shock load conditions. In sports and recreation equipment they provide smooth, maintenance-free performance, offering the same advantages plus corrosion-resistance and environmental compliance for hydropower plants. In primary metals production, GGB bearings stand up to dirty environments and extreme temperature and load conditions. In the general industry, they are used in more than 30,000 different applications.
As the global leader in high performance bearing solutions, GGB serves more than 50,000 customers worldwide through its four-continent production platform and supply network. The company employs more than 1,000 people in 10 manufacturing facilities in Germany, the U.S., France, Slovakia, Brazil and China, and in sales offices in 18 countries. The company also maintains a global network of distributors.
With a history dating back more than 100 years, GGB revolutionized the bearing industry in the mid-1950s with the introduction of its well-known DU® self-lubricating, metal- polymer bearings, the first to use PTFE in the sliding layer, followed in the mid-1960s by its DX® bearings for lubricated applications.
Garlock Inc. was established in the late 1950s to distribute Glacier bearings in the U.S., and subsequently merged with Glacier to form Glacier Garlock Bearings. In 2002, EnPro Industries, a leader in engineered industrial products, acquired the company which has operated as GGB since 2004. In 2022, GGB was acquired by the Timken Company, a global leader in engineered bearings and industrial motion products.


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Dreaming of exotic escapes in sparking blue waters meeting fine golden sand, surrounded by lush vegetation? Dreaming of nestling on the top of a green mountain and letting your eyes lost in velvet blue horizon? Dreaming of time-hopping from one era to another?
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The art of Harry McCue.
Friday, June 29, 2012
Rural Scarecrows
The art of Harry McCue.
Posted by Rot at 9:19 AM
Labels: art, artist, scarecrow, Scarecrows
2 comments:
- bean said...
My goodness...these are beautiful.
- June 29, 2012 at 12:28 PM
- Shani said...
Reminds me of Tyler park. Heading there tomorrow.....way early to try and beat the heat.
- June 29, 2012 at 6:24 PM
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For most people, service is a part-time commitment, part of every week or year, or even a few years given of one's life. More than 61 million Americans volunteer in some way caring for family members, helping friends in a pinch, assisting at schools, churches and hospitals, usually close to home. For a smaller number, service is a way of life a full-time job, a calling. At a time when thousands of young Americans are volunteering in the military, the rest of us are asking with greater urgency what we can and should be doing, not just to help our neighbors but also to serve our country and solve some of the challenges we face here at home.
I found an example recently at a celebration for Returned Peace Corps Volunteers (RPCVS) who teach in some of New York City's most challenging schools. I had always heard that the Peace Corps was a life-changing experience, but I assumed that after spending two years or more living and working in a developing country, often without electricity or running water, most of these young American volunteers would return home to pursue less arduous, more comfortable lines of work. Instead, many bring back the lessons they learned abroad and seek lives of purpose in struggling U.S. communities.
"Peace Corps helps you realize that you are not only an American, you are part of the world," says Jeff Fontenot, who served in the Slovak Republic from 1998 to 2001. "No matter where you go, even if countries are fighting, people want the same things: food and shelter for their families, to get along, to be respected, to be heard. It made me realize what is important is not the go-go-go, get-get-get attitude that we have here in the U.S., but time spent with others and being part of a community." Fontenot now teaches at Brooklyn International High School in downtown Brooklyn. Most of the school's 373 students are poor, 87.2% qualify for free lunches, almost all are immigrants or children of immigrants, and altogether they speak more than 25 languages at home, including Chinese, Vietnamese, Haitian-Creole, Urdu, Fulani, Ukrainian, Spanish, Russian and Arabic. More than a third of the teachers at Brooklyn International served in the Peace Corps, and the skills they developed there help make them good teachers. "They know what it is like to be a stranger in a strange land, to have to learn a new language and to build relationships with people in order to get things done, and that gives them a special empathy," says Pamela Taranto, the school's acting principal.
Working conditions in schools like Fontenot's are difficult. Budgets are small, some students arrive having had little or no schooling in their home countries, and it is often hard to maintain a sense of hope and optimism. In urban schools in general, teacher retention is low, and attracting teachers in shortage areas like math and science is a national challenge. One innovative program, Fellows/USA, nurtures these teachers who make a commitment to service by allowing them to earn a master's degree while they work in poor communities. Started in 1985 at Teachers College at Columbia University, Fellows/USA now offers 50 programs at 42 participating universities in areas such as economics, nursing, public health, agriculture, social work and urban planning, as well as teacher education. About 4,000 RPCVS across the country, including the teachers at Brooklyn International, have earned master's degrees through Fellows/USA.
Reed Dickson, a returned Peace Corps volunteer in Namibia and director of the Teachers College Peace Corps Fellows program, believes that Peace Corps service also has a surprising long-term effect: it makes people want to give of themselves beyond that one experience. "Peace Corps opens your eyes to the disparities that exist in the world and helps develop the political and moral will to stay committed," Dickson says.
In fact, an early investment in service can pay off over a lifetime. The National Education Longitudinal Study of 1988, a trove of high school-related trend data, found that 42% of young people who volunteered in high school did so again eight years later. And a recent study in the American Educational Research Journal identifies community service during high school as a strong predictor of voting and volunteering in adulthood.
Like so many other volunteers, RPCVS will tell you that they learn more than they teach. Ira Weston, who served in Kenya from 1979 to 1981, learned firsthand the power of a teacher to change the world, one life at a time. "It is the relationship with the teacher that can create excellence," says Weston, the veteran principal of Paul Robeson High School, located in a high-crime, gang-infested neighborhood of Crown Heights, Brooklyn. Weston describes his 1,475 students as "at promise" rather than at risk and says he's trying to create "Oz in the projects" a world of color and hope. These teachers, and the other great teachers who have shaped all our lives, represent the fundamental value of service. As Dickson puts it, "They have learned how to put hope in the possible."


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Please visit our Open House at 218 630 ROCHE POINT DR in North Vancouver.
Great Starter Home - Very attractive 673 SF 1 bedroom & den(solarium) in "The Legend". This bright,sunny unit is south facing with a wonderful private outlook over natural green space. Features of this well kept home include 9'ceilings, laminate floors,new dishwasher, insuite laundry, gas fireplace, 1 parking stall & 1 storage locker. Pet & rental friendly building & located only a short walk to all the amenities at Parkgate Village & close to Deep Cove. The area features many hiking & biking trails,skiing, 2 golf courses,Cates Park & only a short distance to Mt.Seymour Pkwy or the Hwy. What more could you ask for - A great home or investment opportunity at a great price. Open House Sat. Oct. 9th 2-4.


text: I recently upgarded from 2.2.0 to 2.2.1 on my Fedora Core 4 system. I had a few troubles to begin with but once I tried the install as the root user, running it out of the root directory it worked fine. I am experiencing an odd problem though. My clients can login with with their e-mail clients just fine as long as SSL is turned off. But when SSL is turned on the clients cannot send or receive e-mail. IMAP is also not working with or without SSL turned on. Steps I have taken so far: I went back to the Fedora Core 4 Perfect Setup guide to double check the Postfix SSL section. I check my main.cf file and all lines that should be added from the FC4PS are there. I telneted into my localhost as port 25 and got the correct response from the server. sals and imap services are running. I am a bit confused as where to look from here. Any advice is welcome. TR


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The fantastical world of Freddie Mitchell has been uneventful recently, but he made news for all the wrong reasons after Lakeland, Fla. police accused him of having pot delivered to his Brothers Bar-B-Q restaurant.
The former "People's Champ" was briefly handcuffed last Thursday, but adamantly denies he had anything to do with the 7-pound box of weed delivered to the restaurant he co-owns. Mitchell claims it's all a big misunderstanding and that the super-aggressive cops are going after the wrong guy. Fred Ex's lawyer, John Liguori, has another theory:
"This was a case of celebrity hunting. They got all excited, and they jumped the gun."
Police tracked the package (delivered via FedEx, no less) after it arrived at Mitchell's 90-year-old grandmother's home and then was shipped off to Brothers Bar-B-Q. When Mitchell came outside to sign for the package, the fuzz pounced.
If there was any doubt that this story was written by Mitchell's hometown newspaper, look no further than the final couple paragraphs:
"First Down Freddie Mitchell" had a variety of nicknames when he played football, including FredEX. He was a star wide receiver for Kathleen High. At UCLA, he caught passes and dated starlets.
In Philadelphia, despite some good years, he lost his job for what he described on MySpace.com as "running my mouth."
Mitchell said he was reluctant to say anything bad about the LPD because the police "are doing a great job in the community."
The investigation is still ongoing at this point and Mitchell is not under arrest.
Ex-NFL Standout Under Scrutiny [The Ledger]


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The city of Wichita was incorporated in 1870, its position on the Chisholm Trail made it a cattle drive destination for cattle drivers headed north. It is known today as the "Air Capital of the World" for its many aircraft corporations, including Cessna and Hawker Beechcraft.
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Filters: Author is Miles, Victoria [Clear All Filters]
An approach for assessing boreal forest conditions based on combined use of satellite SAR and multispectral data. International Journal of Remote Sensing 24, 4447-4466 (2003). Download: 0143116031000070436.pdf (7.9 MB)
Dynamic of tidewater glaciers in the Sermilik Fjord system and fjord-shelf interaction. Palaeoclimatology, oceanography and glaciology in the Helheim Glacier region WORKSHOP (2010). Download: 2010_Abstract_SermilikFjord_AK.pdf (319.47 KB)
Helheim outlet glacier interaction with the Sermilik Fjord on the East Greenland Coast. World Climate Research Programme workshop on seasonal to multi-decadal predictability of polar climate (2010).at <http://www.atmosp.physics.utoronto.ca/SPARC/PolarWorkshop/main.html>
Variability of the Helheim Outlet Glaciers in the Sermilik Fjord on the East Coast of Greenland. ESA Living Planet Symposium (2010).at <http://www.esa.int/SPECIALS/Living_Planet_Symposium_2010/index.html> Download: ESA_living_planet_abstract.pdf (19.42 KB)
Interaction Between the Warm Subsurface Atlantic Water in the Sermilik Fjord and Helheim Glacier in Southeast Greenland. Surveys in Geophysics 32, (2011). Abstract Download: SurvGeophysicsOMJ2011.pdf (2.27 MB)
Satellite archives reveal abrupt changes in behavior of Helheim Glacier, southeast Greenland. Journal of Glaciology 62, (2016).
Spatial heterogeneity of greening and browning between and within bioclimatic zones in northern West Siberia. Environmental Research Letters 11, (2016).
Surface urban heat islands in northern cities. Report Series in Aerosol Science 180, (2016).
Trends in the normalized difference vegetation index (NDVI) associated with urban development of Northern West Siberia. Atmospheric Chemistry and Physics (ACP) 16, (2016).
Warmer urban climates for development of green spaces in northern Siberian cities. Geography, Environment, Sustainability 4, (2016).
Interaction between Society and Environment Reflected in Urban Climates. Urban sustainability in the Arctic: visions, contexts, and challenges (2017).
Seasonal and spatial characteristics of Urban Heat Islands (UHIs) in northern West Siberian cities. Remote Sensing 9:989, (2017). Abstract
Anthropogenic and natural drivers of a strong winter urban heat island in a typical Arctic city. Atmospheric Chemistry and Physics (ACP) 18, (2018).
Anthropogenic heating strongly amplifies the urban heat island in Arctic cities. Atmospheric Chemistry and Physics (ACP) 18, (2018).
Exogenous drivers of surface urban heat islands in Northern West Siberia. Geography, Environment, Sustainability 11, (2018). Abstract
Systematic errors in northern Eurasian short-term weather forecasts induced by atmospheric boundary layer thickness. Environmental Research Letters 13:125009, (2018). Abstract
Arctic cities as an anthropogenic object: a preliminary approach through urban heat islands. The Polar Journal (2019).doi:10.1080/2154896X.2019.1685171
Spatial structure and temporal variability of a surface urban heat island in cold continental climate. Theoretical and Applied Climatology 137, (2019). Abstract
Varying climate response across the tundra, forest-tundra and boreal forest biomes in northern West Siberia. Environmental Research Letters 14:075008, (2019). Abstract
Observations and modelling of ground temperature evolution in the discontinuous permafrost zone in Nadym, north-west Siberia. Permafrost and Periglacial Processes 31, (2020).
Recent trends and remaining challenges for optical remote sensing of Arctic tundra vegetation: A review and outlook. Remote Sensing of Environment 246, (2020).
Surface urban heat islands in 57 cities across different climates in northern Fennoscandia. Urban Climate 31, (2020).
Warmer Climate of Arctic Cities. The Arctic: Current Issues and Challenges (2020).at <https://novapublishers.com/shop/the-arctic-current-issues-and-challenges/>
An enhanced integrated approach to knowledgeable high-resolution environmental quality assessment. Environmental Science and Policy 122, (2021).


text: A haunting and demented twisted piano plays a scary horror theme! A scary and haunting piece of Horror / Thriller music with elements of murder, mystery, death, danger and suspense! Very Scary, tense and ominous with plenty of suspense and fear! A great piece of Horror / psychological thriller music for all your scary projects!