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White is the color of innocence, a trait that most of these popular anime girls with white hair, grey hair, and silver hair portray in beautiful ways!
The following data was taken from the Character Ranking Page on MAL on the date of publication and is based on the amount of times each character is added to a user's "Character Favorites" section.
15. Index Librorum Prohibitorum from Toaru Majutsu no Index (A Certain Magical Index)
Members Favorites: 599
This petite nun with long silver hair belongs to the church of Necessarius, also known as the "Church of Necessary Evil." Index may look innocent and naive, but she is actually pretty amazing, holding over a hundred thousand magical texts inside her head. Now that's what I call a photographic memory!
14. Neferpitou from Hunter x Hunter
Members Favorites: 805
Neferpitou's gender may not be specified during the series, but one thing is for certain: this powerful Chimera Ant with pure white locks is one of the most beautiful characters in anime!
13. Laura Bodewig from IS: Infinite Stratos
Members Favorites: 937
Laura is a genetically created super soldier who wears a modified school uniform that resembles that of her formal post as an army officer. Her long silver hair matches the eyepiece she wears to conceal the marks she got from a failed experiment.
12. Fremy Speeddraw from Rokka no Yuusha (Rokka: Braves of the Six Flowers)
Members Favorites: 978
Fremy's designation as the saint of "powder" is fitting, especially with her powder white hair.
11. Togame from Katanagatari
Members Favorites: 1,151
Togame works under the shogunate in the Edo era of Japan as a strategist. Her hair was once black, but after witnessing her father's death, it changed to snow white.
10. Kyouko Kirigiri from Danganronpa
Members Favorites: 1,236
Super-sleuth Kirigiri is on the hunt to uncover the latest death in Hope Peak Academy's game of despair. In order to stay alive, this silver-haired detective pays close attention to details that the other students fail to notice. Watch as she sneakily slips around the corner!
9. Isla from Plastic Memories
Members Favorites: 1,351
Isla is an android created with human emotions who progressively learns more as she interacts with humans. Her beautiful white hair is flawless, regardless of the seasons.
8. Koneko Toujou from Highschool DxD
Members Favorites: 1,357
Koneko is a Nekomata from the Nekoshou species. In her Nekomata form, Koneko grows a pair of white cat ears and a tail to match. Koneko's name translates to "kitten" and as we can see, she is just as adorable as one!
7. Suigintou from Rozen Maiden
Members Favorites: 1,761
Suigintou's the only doll that possesses wings, which she, in pure Suigintou style, haughtily displays. The pure white of her hair contrasts against her Gothic fashion sense.
Fun fact: Suigintou's artificial spirit is named Meimei after the Japanese word Mei meaning darkness.
6. Nao Tomori from Charlotte
Members Favorites: 1,170
Tomori is the picture of excited innocence as she jumps around with her flowing white hair. With her handy camcorder at her side, this anime girl with white hair is ready to capture the latest and greatest ability user in action.
5. Eucliwood Hellscythe from Kore wa Zombie desu ka? (Is This a Zombie?)
Members Favorites: 2,385
Eu appears as a young girl from medieval times dressed in silver armor with a silver headpiece in her white hair. This headpiece is made to suppress her uncontrollable powers as a necromancer. Unfortunately, even with suppressed powers, this white-haired anime girl is still strong enough to shatter her housemate's arm.
4. Meiko Honma (Menma) from Ano Hi Mita Mita Hana no Namae wo Bokutachi wa Mada Shiranai. (anohana: The Flower We Saw That Day)
Members Favorites: 3,140
Menma thought she was playing a game, but what she was actually doing was... falling off the bed?! Watch as Menma, and her light grey hair, fall gracefully to the ground.
3. Shiro from Deadman Wonderland
Members Favorites: 3,314
Hip-hip-hooray! Shiro is a bubbly and energetic character, which may be due to her love for sweets. Her long white hair also contributes to her albino features and accents the madness her "wretched-egg" persona creates.
Fun fact: Shiro's name means white in Japanese.
2. Tomoyo Sakagami from Clannad
Members Favorites: 3,707
What's more beautiful: Tomoyo, or the way her dark grey hair contrasts against the pure white of the falling snow?
1. Kanade Tachibana (Tenshi) from Angel Beats
Members Favorites: 9,141
As an overseer of the dead, this silver haired "Angel" won't be knocked down so easily!
If you just can't get enough of these funky anime hair colors, please feel free to check out the following articles:
・Girls with Blue Hair
・Girls with Black Hair
・Girls with Pink Hair
・Girls with Green Hair
・Girls with Purple Hair
・Girls with Red Hair
・Girls with Blonde Hair
・Girls with Brown Hair


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I am just beginning to start learning web application development, using python. I am coming across the terms 'cookies' and 'sessions'. I understand cookies in that they store some info in a key value pair on the browser. But I have a little confusion regarding sessions, in a session too we store data in a cookie on the user's browser.
For example - I login using
username='rasmus' and
password='default'. In such a case the data will be posted to the server which is supposed to check and log me in if authenticated. However during the entire process the server also generates a session ID which will be stored in a cookie on my browser. Now the server also stores this session ID in its file system or datastore.
But based on just the session ID, how would it be able to know my username during my subsequent traversal through the site? Does it store the data on the server as a dict where the key would be a session ID and details like
I am getting quite confused here. Need help.

subset: commoncrawl


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Processing time
1-2 weeks
Customs and import taxes
Buyers are responsible for any customs and import taxes that may apply. I'm not responsible for delays due to customs.
$13.49 $14.99
This Beautiful Worship Streamer shimmers as it flies!
John 1:14
"And the Word became flesh, and dwelt among us, and we saw His glory, glory as of the only begotten from the Father, full of grace and truth."
- Available in many colors
- This listing is for one streamer
- Made with Tissue Lame fabric which is very light weight and floats.
- Approx. 8" Wide X 72" Long.
- 8" wooden dowel as a handle with spinner and hook.
- Triangle at the top attaching the streamer to the handle. This serves to hold the streamer open during use.
- Tissue Lame' material is very light weight, floats well, is somewhat translucent, and has a shimmering effect.
- I really do hope you enjoy this Beautiful Worship Streamer!
-If you need your Flags in a hurry, I offer rush processing at this link:
-Please place it in your cart with your order.
I will acknowledge your rush order after purchase and change your shipping date.
1-2 weeks
Buyers are responsible for any customs and import taxes that may apply. I'm not responsible for delays due to customs.
Just contact me within: 3 days of delivery
Ship items back to me within: 7 days of delivery
But please contact me if you have any problems with your order.
Because of the nature of these items, unless they arrive damaged or defective, I can't accept returns for:
Buyers are responsible for return shipping costs. If the item is not returned in its original condition, the buyer is responsible for any loss in value.
My regular processing time is up to 14 days. 20 days for bundles, custom, or orders over 3 flag sets. Rush Processing is available for an additional fee.
Swing flags are created to be mobile. They are different from traditional flags because they do not have flagpoles. This allows them to pack into a small bag or large pocket.
Instead of a pole there is a weighted string sewn into one corner allowing them to billow/flow with a swinging motion. The motions take some practice. Ask me about instructional videos and I will send you links.
I have a limited selection of flags that can be shipped "NEXT DAY". These have READY TO SHIP in the title of them and can be found in the Ready to Ship folder. Normally, I hand make every flag from start to finish to order. This is to allow for customization.
But please contact me first so I can get you the best shipping rate.
Please don't confuse Rush Processing with the cost for shipping. My regular processing time is up to 14 days from the date of purchase. Rush Processing shortens my processing time to 3 days.
Shipping is a separate fee that the post office charges to move your items through the mail.
Express Shipping is not the same thing as Rush Processing. It takes me up to 14 days to create your flags by hand. If you Rush Process your order, you jump to the front of the line and I process your flags within 3 days.
Express Shipping will overnight your package through the mail. It has nothing to do with how long the flags take to create.
All of the flags that I make come in matching pairs. The only exceptions are the streamers and the 100in scarf. When ordering it goes like this:
Quantity 1 = 2 matching flags
Quantity 2 = 4 flags
Quantity 3 = 6 flags and so on.
Some people prefer wooden dowels when they start because they provide a bit more stability to the flags. The flex rods, however, provide a different flow, travel well, and are very lightweight.
Here's a video of Adult Size New Day Flags with Flex Rods:
Here's a video of XL Heavenly Skies with Wooden Dowels:
Here's a video of Adult Size New Day Flags with Flex Rods:
Here's a video of XL Heavenly Skies with Wooden Dowels:
My regular processing time is 14-20 days depending on the size of the order.
You can speed up that process by also purchasing Rush Processing at this link. With Rush Processing, I will move your flags to the front of the line and ship them within 3 business days. Please add Rush processing to your cart with your order of flags.
Oct 4, 2023
Love these steamer flags. Going to purchase more of them!
May 24, 2023
Apr 11, 2023
Mar 18, 2023
Mar 4, 2023
The streamers were beautiful! Love the fabric! I received them as promised. However, the finishing around the edges could have been better. Also, I used it for the first time and the hook that attaches the streamer to the rod came off as I was using it. I had to hot glue and super glue it and the other (3) streamers to ensure it would not come out when ministering. Outside of that, I love them!


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Proper Grounding
Proper grounding is critical. Depending on the type and moisture content of the soil, the actual grounding level required by the energizer will vary. For the average soil, it is recommended you use a 5 Joule low impedance charger that is grounded with three, 8-foot ground rods, spaced at least 10 feet apart. If you double the Joule output of the energizer, you need to double the grounding.
Location of the Energizer
The energizer must have an out grounding electrode to prevent unintentional shock. The location of the energizer must never be grounded to your farm's electrical grounds, metal water pipes or to metal objects in a building such as stalls, fences or dividers. Improper grounding puts the metal objects and livestock in the electric fence's earth return path.
The best place for the energizer may be outdoors and away from livestock buildings and the grounded equipment. If you install an energizer indoors, the high voltage must be taken to the outside using high voltage lead cable (20,000-volt insulation is recommended). Electrical wire of the type used or the building wiring with 600-volt insulation must never be used for this purpose.
Low Impedance Energizers
A low impedance energizer delivers a very high current for a very short time. Even if some grass or other vegetation is touching the fence, the system can deliver enough current to control livestock as long as the appropriate number of ground rods has been used. An energizer labeled by a testing laboratory is recommended.
A standard fence circuit can use single or multiple wires with animal contact made between the fence and the earth. In areas where the soil is sandy or dry, the path is easy to obtain and continuous ground is recommended.


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VentureBeat has immediate openings for experienced reporters with a track record of getting scoops and providing smart analysis.
We're looking for two people, one in San Francisco and one in New York, who love covering the business of technology but are not infatuated with it. Reporters with a critical eye, an ability to develop sources, and a knack for breaking news.
For the San Francisco role, we're seeking someone with experience — or a demonstrable interest in — covering Apple and startups, as well as general tech news.
For the New York City role, we're seeking an experienced reporter who can cover general tech news including IPOs, machine learning, and venture capital, to name a few topics.
As a VentureBeat reporter, you'll help define our daily coverage with breaking news, second-day takes, and features. Further, you possess strong writing and analytical skills to help differentiate VentureBeat from the rest of the pack. You're a journalist who is eager to go out and get the stories that other sites don't have. These are full-time staff positions.
If you're as excited as we are, please send a resume, desired compensation, and cover letter containing three links to your best clips to firstname.lastname@example.com. Please put "Tech reporter – SF" or "Tech reporter – NYC" in the subject line.
VentureBeat's mission is to be a digital town square for technical decision-makers to gain knowledge about transformative enterprise technology and transact. Discover our Briefings.


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Looking to raise awareness in a particular market?
Our team has raised over 30 Million Euros in major sponsorships over the last 10 years including:
- League/Cup naming rights
- Stadium naming rights
- Shirt sponsorships
- Player sponsorships
- Video Games Sport sponsorships
If you are a global brand looking to raise awareness in a particular market or a federation/club/video game sports developer looking for new sponsors please contact our sponsorship office to obtain more details of how we can help you achieve your goals.
Contact our London office 44 (0)208 0990 624
"Thank you ever so much Morgan for the photos we are really happy with the branding we have been receiving this summer for the cricket on SKY SPORTS."
– Helen Atlinson, Marketing Manager, Thomas Cook Airlines


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ChessBase is a personal, stand-alone chess database that has become the standard throughout the world. Everyone uses ChessBase, from the World Champion to the amateur next door. It is the program of choice for anyone who loves the game and wants to know more about it.
Press release
LEUVEN, Belgium, 3 October 2011 – Your Next Move™, the annual chess and business event, is proud to announce that chess grandmasters Garry Kasparov and Nigel Short will do battle once again, in a blitz match, 18 years after their World title contest. The match is part of Your Next Move's fifth anniversary celebrations.
The contest will begin in the early evening of Sunday 9 October 2011. There
will be eight blitz games in which the players have just a few minutes to make
their moves. High-level blitz produces fast and exciting games, a format that
will fascinate everyone. The games can be viewed in the auditorium or on a 3D
TV screen. The event will also be live streamed on the Internet via www.exqisport.be
and Genna Sosonko, a former Soviet grandmaster and Dutch international, will
commentate live.
The organizers of this unique chess event comment: "For the fifth anniversary of Your Next Move we wanted to do something different that really promotes chess. We are grateful that both Garry and Nigel have accepted our invitation to play against each other. We are looking forward to some great games."
Members of the media can attend the event in Leuven, Belgium. There will opportunities to interview Garry Kasparov and Nigel Short after the games. Please contact Jan Poté (contact details below) for registering for the event.
|Arrival of guests and media
|Welcome by organizers
|18.30h – 18.45h
|Introduction of chess grandmasters, explanation of the match
|Start of blitz chess between Garry Kasparov en Nigel Short
|Buffet dinner for guests and media. The games can be viewed in the auditorium or on a 3D TV screen
|End of blitz chess, comments from Garry Kasparov and Nigel Short before live audience, interviews.
Stadhuis Leuven, Grote Markt, 3000 Leuven (Belgium)
Press contact:
Jan Poté, PR & Media Relations
M: +32 475 92 55 82; E: email@example.com; W: www.yournextmove.be
About Your Next Move
Your Next Move is the initiative of three entrepreneurs: Inge Geerdens (CVWarehouse), Jan Callewaert (Option) and Gabriel Fehervari (Alfacam). It's objective is to support chess as a sport and to create an impetus among young people aged 6 to 12. The aim is not just to ensure that chess is officially included as part of the final primary education qualifications but to also actually promote chess as a sport. The reasons for this initiative are quite simple. By playing chess young people develop skills that are essential for general development. It encourages them to think and act speedily, strategically and under pressure. Qualities that are very handy in education and during their professional careers. Another aim of the initiators is to thus arouse interest among young people in entrepreneurship.
Here are some beautiful images of the young people Your Next Move has brought to chess. If you are thoroughly enchanted there is more of the same on the official web site.
|About CVWarehouse: CVWarehouse.com is an online recruitment platform where companies and candidates can meet. More info at www.cvwarehouse.com.
|About the Alfacam Group: The Alfacam Group groups the activities of Alfacam, EuroLinX, Euro1080 and the Eurocam Media Centre. Alfacam's main activity is supplying services to TV stations and production houses and it has more than 30 broadcast vehicles. More info at www.alfacam.com.
|About Option
Option is a company that innovates in the field of wireless communications. The company specialises in designing, developing and marketing wireless broadband solutions. More info at www.option.com.
We use cookies and comparable technologies to provide certain functions, to improve the user experience and to offer interest-oriented content. Depending on their intended use, cookies may be used in addition to technically required cookies, analysis cookies and marketing cookies. You can decide which cookies to use by selecting the appropriate options below. Please note that your selection may affect the functionality of the service. Further information can be found in our privacy policy.


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* Our best price : £ 9.96
Eukroma-Lite (Hydroquinone) is a skin lightening cream used for its benefits in reversing the effects of hyperpigmentation. It has become popular as a treatment for age spots, liver spots and melasma.
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|Main Use
|Active Ingredient
|Marketed Name
|Unevenly coloured skin
Eukroma-Lite (Hydroquinone) is a skin lightening cream used for its benefits in reversing the effects of hyperpigmentation. It has become popular as a treatment for age spots, liver spots and melasma. Exposure to the skin can cause liver spots (dark skin), which contributes to the effects of aging.
In other cases, conditions such as chloasma, which cause darkening of the skin on the face, occur as a result of pregnancy or taking contraceptive pills. This anti-hyperpigmentation agent acts on the melanocyte cells (cells which produce the pigment called melanin). This lightens the skin colour and can even the skin tone, making it an effective treatment for unevenly coloured skin.
Dosage and Administration
Eukroma-Lite (Hydroquinone) must be applied topically. Instructions related to proper use will be provided to you by your doctor before treatment starts. Adults treating senile lentigines, melasma, chloasma or other problems may be instructed to apply the cream to the area affected by melanin hyperpigmentation twice per day. Treatment will need to continue for as long as your doctor tells you.
Side effects
Eukroma-Lite (Hydroquinone) can cause mild irritation or other topical reactions at the application site. Most patients do not experience serious side effects. However, if you notice severe stinging, burning or pain after application, cease use of this cream and seek medical care straight away.
Applying this product alongside benzoyl peroxide or other products which contain peroxide may result in stinging.
Do not expose your skin to sunlight and avoid any tanning beds. This cream makes the skin more sensitive to the sun.
Seek immediate emergency medical attention if you suffer an allergic reaction. Symptoms to watch for, which may be indicative of a reaction, include skin rashes, hives, swelling of the face or limbs, trouble breathing, and trouble swallowing.
Always use Eukroma-Lite (Hydroquinone) as you have been prescribed by your doctor. Never self-medicate or change your dosage without first consulting your doctor. The correct dosage can vary depending on your health, medical history, and the severity of the condition being treated.
This medication may not be safe for all patients. Before you begin using it always disclose the following to your doctor:


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The Chromosome 9p21 Variant Not Predicting Long-Term Cardiovascular Mortality in Chinese with Established Coronary Artery Disease: An Eleven-Year Follow-Up Study
Introduction. We examined whether the variant at chromosome 9p21, rs4977574, was associated with long-term cardiovascular mortality in Han Chinese patients with coronary artery disease (CAD). Methodology. Subjects who underwent coronary angiography for chest pain were consecutively enrolled. Fasting blood samples were collected for laboratory and genotype assessments. The information was correlated with data collected from the national death database. Results. There were 925 cases with CAD and 634 without CAD enrolled in the present study. The G allele conferred a significant increase in risk of CAD (odds ratio = 1.47, in the dominant model; odds ratio = 1.36, in the recessive model). During a median of 11 years (inter-quartile range between 5.2 and 12.5 years) of follow-up, neither the total nor the cardiovascular mortality was different among CAD subjects with different genotypes. Using Cox regression analysis, genotypes of rs4977574 still failed to predict cardiovascular mortality (hazard ratio = 1.25, in the dominant model; hazard ratio = 1.05, in the recessive model). Conclusions. The rs4977574 at chromosome 9p21 is associated with presence of CAD in Han Chinese. However, rs4977574 could not predict cardiovascular mortality in these CAD subjects during the eleven-year period of the study.
1. Introduction
Coronary artery disease (CAD) is the leading cause of death worldwide [1]. Heredity plays an important role in CAD susceptibility [2]. The chromosome 9p21 region has been shown to be associated with CAD, and several single nucleotide polymorphisms (SNPs) selected from Caucasians have been replicated in Chinese [3–5]. However, SNPs in chromosome 9p21 contribute diverse intensities of risk to cardiovascular disease, and it has been reported that the effect size of identified SNPs is dependent on the chosen population [6–8].
Among the tag SNPs, rs4977574 has been initially demonstrated to be associated with risk of CAD in the Myocardial Infarction Genetics Consortium (MIGen) study [9]. The association between rs4977574 and CAD has also been found in several populations [10–13]. However, a small study comprising 334 subjects did not show any significant association between CAD risk and rs4977574 in a Chinese population [14].
Although rs4977574 was recently reported to be associated with cardiovascular incidence in the subjects without CAD at baseline [15], results from longitudinal assessments between 9p21 variants and cardiovascular mortality in subjects with established CAD were inconsistent. In the Global Registry of Acute Coronary Events (GRACE) genetic study, the 9p21 variant showed a significant association with cardiovascular death [16]. However, Virani et al. [17] recently reported that the 9p21 variant was not associated with cardiovascular outcome. In order to clarify the long-term impact of 9p21 variant on cardiovascular mortality in CAD patients, we therefore examined the polymorphism of rs4977574 in a Taiwanese cohort of Han Chinese descent in an eleven-year follow-up duration.
2. Material and Methods
2.1. Patients
The participants were enrolled during hospitalization in the Cardiovascular Department in Taichung Veterans General Hospital between March 1999 and March 2000. The study comprised both case-control and follow-up assessments for subjects undergoing coronary angiography due to angina and clinical suspicion of ischemic heart disease. Blood samples were collected after the subjects had fasted overnight. Mortality data up to 2011 were collected for the follow-up assessment. The study protocol was approved by the Institutional Review Board of Taichung Veterans General Hospital, Taichung, Taiwan.
2.2. Methods
Genomic DNA was extracted from patients' peripheral blood leukocytes using a QIAamp DNA Blood Mini Kit (Qiagen, Hilden, Germany). Genotypes of rs4977574 were determined using TaqMan allelic discrimination assay (Custom TaqMan SNP Genotyping Assay). The genotyping reaction was amplified and detected on a StepOnePlus Real-Time PCR (Applied Biosystems, Foster City, USA).
Plasma glucose was determined using the glucose oxidase-peroxidase method (Wako Diagnostics, Tokyo, Japan). Serum cholesterol and triglyceride levels were determined by the enzymatic method using commercial kits (Wako Diagnostics, Tokyo, Japan). High-density lipoprotein (HDL) cholesterol was determined after the precipitation of apo B-containing lipoproteins. Low-density lipoprotein (LDL) cholesterol concentration was calculated using the formula of Friedewald et al. [18] if fasting serum triglyceride was less than 4.5 mmol/L. Otherwise, LDL cholesterol was determined after separation of very-low-density lipoprotein (VLDL) from serum by ultracentrifugation and precipitation of apo B-containing particles.
2.3. Exposure Information
The subjects were assigned to the CAD group if they fulfilled one or both of the following criteria: (1) a history of myocardial infarction or coronary revascularization or (2) 50% or more luminal narrowing in any coronary artery according to angiography. Subjects who did not fulfill any of these criteria were assigned to the non-CAD group. Diabetes mellitus was defined as (1) a history of diabetes mellitus or use of antidiabetic medications or (2) fasting blood glucose levels equal to or higher than 7.0 mmol/L. Hypertension was defined as (1) a history of hypertension or use of antihypertensive medications or (2) systolic blood pressure higher than 140 mmHg or diastolic blood pressure higher than 90 mmHg.
The coronary artery lesions were assessed at the angiography viewing workstation using software for quantitative analysis (Philips Inturis Suite, R2.2, Philips Medical Systems, Eindhoven, Netherlands). The baseline CAD severity was evaluated by Gensini score, which was calculated by the sum of obstructive severity score times the lesion location score system [19].
The mortality data were provided by the Collaboration Center of Health Information Application (CCHIA), Department of Health, Executive Yuan, Taiwan. The causes of death were determined according to the International Classification of Disease, 9th Revision, Clinical Modification (ICD-9 CM) diagnostic criteria. Cardiovascular disease was defined as CAD (402, 404, 410, 411, 412, 413, 414, 426, 427, 428, and 429), cerebrovascular disease (430, 431, 432, 433, 434, 435, 436, 437, and 785.9), and peripheral artery disease (440.2, 443.8, 443.9, and 444.2) [20].
2.4. Statistical Analysis
Data are presented as mean ± standard deviation (SD). The genotype distribution was tested for Hardy-Weinberg equilibrium by the goodness-of-fit test. Chi-square test was used to assess the differences in gender, genotypes, diabetes, hypertension, and smoking status. The differences in continuous variables at baseline were analyzed by independent -test. Multivariate logistic regression analyses were used to assess the genetic effects on CAD at baseline. Multivariable Cox proportional-hazard regression analyses were used to examine the cardiovascular mortality between genotypes. Statistical analysis was performed using SPSS 19.0 (SPSS Inc., Chicago, IL, USA).
3. Results
3.1. Case-Control Assessments at Baseline
A total of 1559 subjects were enrolled with 925 in the CAD group and 634 in the non-CAD group (Figure 1). The distribution of alleles was in agreement with the Hardy-Weinberg equilibrium. The clinical features of the two study groups are shown in Table 1. The CAD group was significantly older with male dominance compared with the non-CAD group (both values less than 0.001). There were significantly higher proportions of current smoking status (), hypertension (), and diabetes mellitus () in the CAD group than those in the non-CAD group. Fasting serum concentrations of LDL cholesterol and total cholesterol were also significantly higher in the CAD group than those in the non-CAD group (both values less than 0.001). The genotype distributions showed that G allele of rs4977574 was overrepresented in the CAD group compared to the non-CAD group ( for genotype distribution and for allele distribution, resp.). The risk allele remained independently associated with CAD after adjusting for age, gender, smoking, hypertension, diabetes, and LDL cholesterol in the logistic regression model (Table 2).
3.2. Longitudinal Cardiovascular and Total Mortality for CAD Patients
Among the 925 patients with CAD at baseline, there were 248 with GG genotype, 479 with GA genotype, and 198 with AA genotype (Table 3). The CAD severity, based on the Gensini score, was not significantly different among all genotypes (). During the follow-up period (median of 11.0 years, interquartile range between 5.2 and 12.5 years), there was no significant difference in cardiovascular mortality or total mortality among the CAD patients with different genotypes (Figure 2). Using Cox regression analysis, the risk G allele was not associated with cardiovascular mortality and total mortality in either the dominant model or the recessive model after adjustment for age, gender, smoking status, past history of myocardial infarction, statins treatment, presence of hypertension, and presence of diabetes (Table 4).
4. Discussion
Our major findings were that the G allele of SNP rs4977574 was associated with the presence of CAD but failed to predict cardiovascular death in the Han Taiwanese patients with established CAD. The case-control findings of our study are in-line with results reported in other populations [9–13]. SNP rs4977574 is located at a locus with a gene encoding a large antisense noncoding RNA (ANRIL) [21, 22]. ANRIL might be involved in atherosclerosis by being expressed in the endothelial cells and monocyte-derived cells [21, 23]. Upstream from the locus, the cyclin-dependent kinase inhibitor 2A (CDKN2A) and 2B (CDKN2B) genes are associated with transcriptional regulation of ANRIL [24–26]. It is also important to note that the baseline Gensini scores were not significantly different among the CAD patients with three different genotypes. In accordance with our observations, Chen et al. [27] reported that the 9p21 variant is not associated with CAD severity in subjects with established CAD. Similar findings, reported in Chinese subjects with myocardial infarction, showed that severity of coronary lesion was not significantly different among different genotypes of the 9p21 variant [28]. Further investigations are warranted to clarify the underlying pathogenesis contributing to the observed association between chromosome 9p21 variants and coronary lesions.
In the present study, rs4977574 failed to predict cardiovascular or total mortality in subjects with CAD during the eleven-year period of follow-up. Our finding in CAD Chinese was different from results in subjects without CAD [15]. Furthermore, the GRACE genetic study showed the 9p21 variant was significantly associated with recurrent myocardial infarction within only six months [16], but Peng et al. [28] reported that the 9p21 variant could not predict total mortality in subjects following myocardial infarction in a 2.5-year study. Virani et al. [17] also found no significant association between the 9p21 variant and cardiac death in subjects with established CAD in a 3.2-year follow-up. One of the main strengths of the present study was that long-term mortality in a follow-up period of 11 years was analyzed in CAD patients, using death records as the endpoint to test our hypothesis.
It is well acknowledged that the current established risk factors of atherosclerosis are not able to fully account for cardiovascular death [29]. The discrepancy probably results from different pathophysiological mechanisms. Endothelial dysfunction and monocyte activation play roles in inflammation and subsequent development of coronary lesions [30, 31]. However, the atherosclerotic biomarkers and monocyte activity were poor predictors of longitudinal cardiovascular events in patients with established CAD [32]. In fact, cardiovascular death might be associated with the critical mechanisms of plaque stabilization and arrhythmia in CAD patients [33–35]. In large-scale genome-wide association studies (GWAS), susceptibility variants were determined based on case-control studies, and thus it might not be possible to prospectively predict the outcomes of diseases [36]. Previous authors have asserted that the effects of the 9p21 genetic polymorphisms might be only associated with coronary lesion but not capable of predicting cardiovascular mortality [37, 38]. Furthermore, cardiovascular death might be associated with many common diseases, which in turn may be linked to both genetic and environmental factors [39, 40]. The association between chromosome 9p21 variants and sequential cardiovascular mortality might be abated by the medical treatment or procedural intervention during the follow-up period [41]. Along the same lines, it has been reported that the 9p21 variants could not predict the cardiovascular outcomes in subjects with coronary lesions after drug-eluting stent placement [42].
Cavender et al. [43] reported a total mortality of 37% in subjects with CAD at five years. In the present study, the accumulative total mortality of about 55% was observed in a median 11-year period of follow-up. Ethnic differences in mortality were reported in CAD subjects, with a higher mortality in Asians compared with that in Caucasians [44, 45]. However, the prognosis of CAD seems to be better in Chinese than that in south Asians, although the mechanism is not well understood [46]. In a recent report from a Vienna cohort study with a similar duration of follow-up [47], a lower total mortality rate (39%) in the CAD subjects was observed, although the proportion of cardiovascular cause (57%) was similar to that in the present study (56.6%). Because the majority of deaths in the present study were cardiovascular causes, the total mortality findings were close to those of cardiovascular mortality.
There were some limitations in the current study. First, the cardiovascular mortality data was collected from the national mortality registry which covers 99.6% of the total population in Taiwan [48]. However, nonfatal cardiovascular events could not be traced in the follow-up assessment as these data are not provided in the database. Second, we assessed cardiovascular mortality rather than CAD mortality due to indistinct classifications of death causes; for example, some types of CAD might be classified to cardiovascular disease (ex. ICD-9 code of 429.2) [49]. Furthermore, we could not collect information on the effect of environmental factors and treatments during the follow-up period.
In conclusion, the SNP rs4977574 at chromosome 9p21 was an independent risk factor for CAD in Taiwanese individuals of Han Chinese descent. However, this SNP could not predict the total or cardiovascular mortality in these subjects, who had CAD at baseline, during the eleven-year period of follow-up.
Conflict of Interests
The authors declare that there is no conflict of interests regarding the publication of this paper.
This work was supported by Grants from Taichung Veterans General Hospital, Taichung, Taiwan, [TCVGH-1013501B and TCVGH-103DHA0500405] and National Science Council, Taiwan [NSC 102-2314-B-075A-001].
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Frontiers eBooks published in January 2018
Below is a list of Frontiers eBooks published in January 2018. All Frontiers eBooks are free to download, share and distribute.
Modeling the Plankton–Enhancing the Integration of Biological Knowledge and Mechanistic Understanding, Hosted by Christian Lindemann, Dag L. Aksnes, Kevin J. Flynn and Susanne Menden-Deuer
Brain-Mind-Body Practice and Health, Hosted by Gao-Xia Wei, Gangyan Si and Yi-Yuan Tang
Salinity Tolerance in Plants: Mechanisms and Regulation of Ion Transport, Hosted by Vadim Volkov and Mary J. Beilby
Novel Therapeutic Targets and Emerging Treatments for Fibrosis, Hosted by Chrishan S. Samuel and Timothy D. Hewitson
The Clinical and Ethical Practice of Neuromodulation – Deep Brain Stimulation and Beyond, Hosted by Markus Christen and Sabine Muller
Social Cognition, Motivation, and Interaction: How Do People Respond to Threats in Social Interactions? Hosted by Eva Jonas and Christina Muhlberger
Organic Ligands in Marine Trace Metal Biogeochemistry in the ocean, Hosted by Kristen N. Buck, Maeve C. Lohan, Sylvia G. Sander, Christel Hassler and Ivanka Pizeta
Biology of Brain Disorders, Hosted by Daniela Tropea and Andrew Harkin
Epigenetic Modifications Associated with Abiotic and Biotic Stresses in Plants: An Implication for Understanding Plant Evolution, Hosted by Mahmoud W. Yaish, Heribert Hirt and Barbara Hohn
Mental Health Challenges in Elite Sport: Balancing Risk with Reward, Hosted by Tadhg Eoghan MacIntyre, Judy Van Raalte, Britton W. Brewer, Marc Jones, Deirdre O'Shea and Paul Joseph McCarthy
Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function, Hosted by Amit V. Pandey, Colin J. Henderson, Yuji Ishii, Michel Kranendonk, Wayne L. Backes and Ulrich M. Zanger
Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer, Hosted by Tammy A. Morrish and Jose Luis Garcia Perez
Peripheral Nervous System-Machine Interfaces, Hosted by Michael Wininger, Panagiotis Artemiadis, Claudio Castellini and Patrick Pilarski
Advances in Research on Age in the Workplace and Retirement, Hosted by Cort W. Rudolph, Hannes Zacher and Susanne Scheibe
Genetics of Acquired Antimicrobial Resistance in Animal and Zoonotic Pathogens, Hosted by Axel Cloeckaert, Michel Stanislas Zygmunt and Benoit Doublet
The Pathogenetic Mechanisms at the Basis of Aortopathy Associated with Bicuspid Aortic Valve: Insights from "Omics", Models of Disease and Emergent Technologies, Hosted by Amalia Forte and Alessandro Della Corte
The Cognition of Sequences, Hosted by Snehlata Jaswal
Regulation of Inflammation, Its Resolution and Therapeutic Targeting, Hosted by Mariagrazia Uguccioni, Mauro Martins Teixeira, Massimo Locati and Alberto Mantovani
Immunobiotics: Interactions of Beneficial Microbes with the Immune System, Hosted by Julio Villena and Haruki Kitazawa
Modeling Disease Spread and Control, Hosted by Tariq Halasa and Salome Durr
Allorecognition by Leukocytes of the Adaptive Immune System, Hosted by Gilles Benichou and James Kim
International Perspectives on Health and Safety among Dairy Workers: Challenges, Solutions and the Future, Hosted by Martina Jakob and John Rosecrance
Charged Particles in Oncology, Hosted by Marco Durante, Francis A. Cucinotta and Jay S. Loeffler
On the Origin and Function of Human NK-like CD8+ T Cells: Charting New Territories, Hosted by Fernando A. Arosa
Update on the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine, Hosted by Vera Hirsh and Barbara Melosky
The Trigemino-Cardiac Reflex: Beyond the Diving Reflex, Hosted by Bernhard Schaller and Tumul Chowdhury
The Neonatal Immune System: A Unique Host-Microbial Interface, Hosted by Joseph M. Bliss and James L. Wynn


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The Geothermal Development Facility for Latin America ("GDF" or the "Fund") is privately managed, Mauritius-based foundation with an initial capitalization of €50 million from the German government (KfW) and the European Union (EU). Other investment in a similar collective amount from multilateral development financial institutions (CAF, IDB, World Bank, CABEI, Norfund, AFB, DFID etc.) is under consideration. GDF's purpose is to provide early stage grant funding for geothermal development in 10 countries in Latin America in order to overcome the significant exploration cost hurdles which curtail the economic development of geothermal project. The funding will support surface studies and early stage drilling (first 3 wells) with a goal to create 350MW of geothermal power in the region at an estimated capital requirement of between €1.5 and 2.0 billion when fully deployed. By addressing exploration the fund will facilitate subsequent sources of Development Finance Institution (DFI) funding to support the commercialization of the proven geothermal resource, and GDF is a catalyst to reaching a stage where those funds can be mobilized. The foundation is managed by U.S.-based IDA Fund Management, LLC ("IDA"), which is a consortium consisting of Interlink Capital Strategies, the Dewhurst Group and Chris McCormick from Ambata Capital. These are well-known professional service companies actively involved in structured finance in emerging markets and geothermal development, which won an international tender conducted by KfW in the 2nd quarter of 2016. The formal launch of GDF will be in the fourth quarter of 2016, with the first solicitation for proposals to occur before or within the first quarter of 2017.
Alan Beard, Managing Director, Interlink Capital Strategies
Mr. Beard has over 20 years of international finance and business development experience. Previously, he was the COO of Delphos International, a Washington, DC-based consulting firm that arranged several billion dollars in government grants, equity, guarantees and loans for more than 700 companies.
Joseph Szamosfalvi, Managing Director, Interlink Capital Strategies
Mr. Szamosfalvi is specialized in emerging market project and structured finance underwriting and risk mitigation with a focus on infrastructure, financial and energy sector projects. He has provided fair market value analysis and led or advised on mergers and acquisition projects in the manufacturing, and biofuels industries in the US and abroad (Japan, Malaysia, among others).
Kerry McCallum, Chief Operations Officer, Dewhurst Group
Mr. McCallum is specialized in geothermal exploration and development services. He has a broad background in engineering operations with experience in geothermal development and exploration projects in Mexico, Colombia, New Zealand, Australia, the United States and Canada.


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Put a Stop to Live Animals in Keychains and Mobile Phone Trinkets in China!
Stop the cat and dog meat trade in South Korea
Please Shut Down the Yulin Dog Meat Festival in GuangXi China
Boycott Busan International Film Festival -
Hundreds of thousands of puppies are killed at the Busan Gupo Dog Meat Market every year!
Nobody touch the cat - We ask to stop the terrible practice of eating Cat meat and tortures to which the Cats are subjected in China.


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This is Boudicca doing "Up." It's a common trick some dogs are capable of doing. That's great, she's too cute, but the point here concerns dog learning and building foundation skills.
The fountain in the background is located at Island Park near downtown Sarasota, across from Marina Jacks Restaurant and fueling docks.
The fountain is set down in that gray cement wall with an outcropping of shrubs set into another wall about 3 feet deep, from outside rim to inside edge of gray wall. Boudicca has known how to jump up, get on the plaque and on the edge of the fountain wall, but she has never been encouraged to walk completely around the fountain on that edge.
Today, within two-three trials, using verbal cues for example "fountain" and "walk" she learned to walk the entire perimeter of that inner fountain wall. We increased speed, using the same cues, simply by increasing how fast i circled the wall from the ground.
I couldn't target train this behavior, getting on the wall was not possible, the shrubs created an obstacle making that an unlikely option. I couldn't shape it, again too many obstacles and treat delivery would have been difficult, however, these restraints never deterred Boudicca from learning this task.
How, one might ask? I've taught Boudicca to pay attention to verbal cues in addition to using hand targeting and directional information. Because she has this ability, I sent her "up" to the "fountain" edge, cued her to "walk" and she followed me around the entire perimeter of the fountain. All these cues she had previously learned. All that was necessary was chaining them together into this new sequence. How easy is that! For Boudicca, it was pretty easy. This week, we'll get back down and try to get some video!
Here it is! http://www.youtube.com/watch?v=AwsL44gTOfU&feature=plcp
Yeah Boudicca! It's things like this that remind me how grateful I am to have such a wonderful dog! 😎


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Religious group to protest at funeral for Ill. soldier
(Local News ~ 06/17/05)
ANNA, Ill. -- The mourners of Spc. Brian Romines won't be the only ones present at his funeral Saturday morning. An extremist religious group will be there, as well, preaching a hateful message outside the Anna Heights Baptist Church, location of the service...
Unclaimed property held by state
(Local News ~ 06/17/05)
Millions of Missouri residents have some sort of assets they probably don't realize they have, and the state government is holding that property for safekeeping until those residents come forward. The Missouri Treasurer's Office recently released lists of unclaimed property owners -- a list that currently contains about 2.2 million names of state residents, living and dead, said Lana Massman, assistant director of the office's unclaimed property division...
United Way allocating money from record fund-raising effort
(Local News ~ 06/17/05)
After breaking its first-ever million-dollar goal last year, the United Way of Southeast Missouri is doling out the dough. United Way raised $1.069 million in 2004, and the organization is distributing more than $663,000 this year to among 32 charitable organizations in Cape Girardeau, Jackson, Scott City and Perryville. Of these organizations, the American Red Cross received the most money allocated to a single agency, $80,000, for emergency services...
Program brings together youths from all walks of life
(Local News ~ 06/17/05)
A few weeks ago, Jake Cypret, 16, of Cape Girardeau couldn't have told you what turtle head roses looked like. But on Thursday afternoon, he was busy planting them along the pond out by the new conservation nature center. "They're small pink flowers," Cypret explained. "They attract humming birds, bees and butterflies."...
Cape man found guilty of raping 14-year-old girl
(Local News ~ 06/17/05)
A Cape Girardeau County jury took less than an hour to find Fred L. Harris Sr. guilty of forcibly raping a 14-year-old girl after allegedly telling her that he was "looking for a wife" and that he wanted to get her pregnant with his twins. The four-man, eight-woman jury found Harris, 53, of Cape Girardeau guilty of forcible rape Thursday at the conclusion of a two-day trial held at the county courthouse in Jackson in front of Circuit Judge Ben Lewis...
City- Signs not warranted at Cape hilltop intersection
(Local News ~ 06/17/05)
The hilltop intersection of Missouri Avenue and Stoddard Street doesn't warrant signs to slow down traffic, Cape Girardeau city officials say, insisting that most motorists aren't speeding through the residential neighborhood. But neighborhood residents still worry that speeding motorists, line-of-sight problems and children at play could lead to a deadly accident...
Kindergarteners in training
(Local News ~ 06/17/05)
By Callie Clark Miller From the 3 1/2-foot-tall perspective of a 5-year-old, the side of a school bus is a towering wall of yellow with steps that require a gigantic leap of faith to ascend. On Thursday, 120 pre-kindergarteners did it together at Jackson's Primary Annex, carefully traversing the steps with a helping hand from the student in front of them...
Auditor: Export claims a sham
(State News ~ 06/17/05)
An office of the Missouri Department of Economic Development can't back up its successes, Claire McCaskill says. JEFFERSON CITY, Mo. -- A state agency that assists Missouri companies in securing contracts to export goods to foreign countries can't back up many of its claims of success, a state auditor's report issued Thursday says...
Missouri board divided on Arab Bank
(State News ~ 06/17/05)
The board is debating how to handle state money invested in the bank, a target of terrorism-related lawsuits. JEFFERSON CITY, Mo. -- The state retirement system board refused Thursday to pull money out of a bank that State Treasurer Sarah Steelman believes has terrorism ties...
Iraqi factions forge political victory
(International News ~ 06/17/05)
BAGHDAD, Iraq -- The political wrangling of Iraq's infant government can seem futile in the face of relentless violence. But Iraqi lawmakers say politics is their best hope to prevent civil war and send foreign troops home -- and on that front, they claimed a victory Thursday...
Seasons passed
(Community Sports ~ 06/17/05)
Local fans can get a ticket to the past at Cape Girardeau sports exhibit. John Holcomb acknowledges that a lot of sweat went into the new sports exhibit that will be unveiled this weekend at the Cape River Heritage Museum. But the retired Cape Girardeau doctor wouldn't have it any other way...
Browne, Mediate surface in the red
(Professional Sports ~ 06/17/05)
The duo made for unlikely first-round leaders as Pinehurst allowed just nine players to shoot under par. PINEHURST, N.C. -- Olin Browne strolled to the cup as his 18-foot putt dropped on the toughest hole at Pinehurst No. 2, making it look like just another routine birdie...
Ailment gives new outlook for Eldred
(Professional Sports ~ 06/17/05)
ST. LOUIS -- Coming back from elbow surgery that sidelined him for almost two seasons and left him for a time with a rod implant for stabilization gave Cal Eldred a greater appreciation for every pitch he made. Returning from a potentially life-threatening heart illness gave him a greater appreciation for everything outside of baseball...
Pistons pull even with rout of Spurs
(Professional Sports ~ 06/17/05)
Detroit claimed Game 4 with a 102-71 pasting of San Antonio. AUBURN HILLS, Mich. -- Tayshaun Prince looked down upon Manu Ginobili from the right wing, faked him out with a quick move and darted to the basket for a resounding dunk. It was easy, really. Almost too easy...
Good looking, good driving
(Column ~ 06/17/05)
Revamped Hyundai Sonata has large-car dimensions The first time I heard of a "sonata" was in a music appreciation class. That was in the '60s when the music I appreciated was made with three guitars, a set of drums, and longhaired hippies yelling, "I wanna hold your hand." Today there are Hyundai Sonatas everywhere...
Adults hold their own spelling bees
(National News ~ 06/17/05)
CHEYENNE, Wyo. -- It is said that youngsters in the Scripps National Spelling Bee in Washington never forget the misspelled word -- like "trouvaille" or "odylic," to name recent troublemakers -- that knocks them out of the competition. So why not try to set things right as a grown-up?...
Runaway bride pitches a proposal for TV project about her life
(Entertainment ~ 06/17/05)
ATLANTA -- Runaway bride Jennifer Wilbanks has struck a deal for a TV project about her misadventures, irritating some people in her hometown. ReganMedia, which publishes books and produces TV shows and movies, said Thursday that it has acquired all media rights to the stories of Wilbanks and her fiance, John Mason. The New York company did not say whether any money had changed hands...
European Union considers shelving constitution talks
(International News ~ 06/17/05)
BRUSSELS, Belgium -- European Union leaders discussed putting their plans for a continental constitution on hold Thursday, seeking time to reassess the bloc's future after French and Dutch voters rejected the charter and cast doubt on Europe's 50-year drive for greater unity...
Roddick finds path to final strewn with potential pitfalls
(Professional Sports ~ 06/17/05)
WIMBLEDON, England -- To get to the Wimbledon final, Andy Roddick may first have to get past the tallest player on the tour, the local favorite and the game's newest darling. Defending champion Roger Federer seems to have an easier path after Thursday's draw. His toughest projected match could come in the semifinals, with possible opponents being 2002 champion Lleyton Hewitt or last year's semifinalist Mario Ancic...
Wild Tiger stays in the hunt
(Professional Sports ~ 06/17/05)
PINEHURST, N.C. -- Tiger Woods hit a tree, muffed a pitch, missed eight fairways and seemed always to be pondering a way to get out of his next jam. He knew he wasn't going to win the U.S. Open on Thursday. The way he was spraying the ball around Pinehurst No. 2, his job became finding a way not to lose it...
Morgan grabs lead at Rochester
(Professional Sports ~ 06/17/05)
PITTSFORD, N.Y. -- Becky Morgan shot an 8-under 64 in cool, rainy conditions Thursday to take a three-stroke lead over Lorena Ochoa after the opening round of the Rochester LPGA. Ochoa closed with three straight birdies for a 67, one ahead of Maria Hjorth (68) and two in front of 2003 U.S. Women's Open champion Hilary Lunke (69). Se Ri Pak, Christina Kim, Laura Diaz and Rachel Hetherington were at 2 under...
Boy is 49th KC homicide this year
(State News ~ 06/17/05)
KANSAS CITY, Mo. -- A 12-year-old boy brought to a fire station by his mother after being injured in a drive-by shooting became Kansas City's 49th homicide victim of the year, as the city runs well ahead of the 2004 pace. The boy was shot Wednesday evening as he stood outside a residence with a group of other people...
Editor's murder linked to Chechen
(International News ~ 06/17/05)
MOSCOW -- Prosecutors said Thursday they had solved the murder of U.S journalist Paul Klebnikov, linking his high-profile killing to a former Chechen separatist figure who was the subject of a critical book that he wrote. Some observers remain skeptical about the Chechen connection, saying Klebnikov had delved deep into the still-murky post-Soviet business world in his work as the editor of Forbes magazine's Russian edition...
International nursing school opens amid nurse shortage
(International News ~ 06/17/05)
BASSETERRE, St. Kitts -- Kate Zajdel was among tens of thousands of qualified applicants turned away by U.S. nursing programs last year because there are not enough teachers or space. The dilemma brought the 22-year-old New Yorker to a new international nursing school in the Caribbean country of St. Kitts and Nevis, joining a class of 24...
Post M Travelers makes plans for Saturday picnic
(Local News ~ 06/17/05)
The Cape Girardeau Post M Travelers Protective Association will hold its first family picnic at 6 p.m. Saturday, June 18 at Cape Girardeau County Park shelter no. 4. Menu includes hamburgers, brats, hot dogs, side dishes and desserts. Games will be available for all age groups. Bert Daume, who became a member of TPA in 1955 will be recognized for 50 years of service...
Favorite Tulane ready to take on old guard
(Professional Sports ~ 06/17/05)
OMAHA, Neb. -- Tulane is ready to take on the big boys at the College World Series. Three teams from the Big 12, two from the Southeastern Conference and two from the Pacific-10 made it to Omaha, but it's the top-seeded Green Wave from Conference USA who are favored to win their first national championship...
Area digest June17
(College Sports ~ 06/17/05)
Gators sweep two swimming meets The Gator Swim Team swept Southeast Missouri Swimming Confence meets June 4 at Perryville and June 11 at Jackson. The Gators scored 1,008 points to win at Perryville. The Perryville Piranhas were third with 398 points. Jackson Swim Team was fourth with 384 points...
County clerk seeking personal information
(Local News ~ 06/17/05)
BENTON, Mo. -- Scott County residents will be receiving letters from the county clerk's office asking for personal information in the county's effort to update its voter registration database. Some of the information requested will be birthdates and Social Security numbers, information which hasn't been asked for in the past but is needed due to new federal and state requirements, said clerk Rita Milam. Social Security numbers and birthdates will be kept confidential by the office...
A wonderful advocate for children
(Letter to the Editor ~ 06/17/05)
To the editor; With the passing of SanDee Casey last week, the greater Cape Girardeau area has lost a wonderful advocate for children. She was a devoted employee of the Greater St. Louis Area Council of the Boy Scouts of America and played an important administrative role in the organization of events, activities and fund raising for over 20 years. ...
A better policy to fight meth
(Letter to the Editor ~ 06/17/05)
To the editor: I'm writing about your thoughtful June 11 editorial, "Methamphetamine." Keeping the ingredients of meth behind the counter is certainly a lot better solution than the previous non-solution of building more and bigger prisons. Oklahoma learned the hard way that the so-called "tough on drugs" policies don't work and are expensive. Largely because of their "tough on drugs" policies, Oklahoma became the fourth highest state for incarcerations...
Sports briefs 6/17/05
(Other Sports ~ 06/17/05)
Lions and cougars and ...
(Editorial ~ 06/17/05)
Whenever sightings of courgars are reported in the news media, a barrage of additional reports is unleashed along with claims of seeing mountain lions and panthers too. Are we, indeed, living in a jungle with creatures usually seen only in zoos? Part of the confusion may be the result of what we call big animals when we see then in our neighborhoods or crossing the roads we travel...
Fire reports 6/17/05
(Police/Fire Report ~ 06/17/05)
Cape Girardeau Firefighters responded to the following calls Wednesday: * At 5:26 p.m., emergency medical service at Route K and Onyx Lane. * At 10:01 p.m., a still alarm at 2307 Kent Drive. Jackson Firefighters responded to the following calls Tuesday:...
Police reports 6/17/05
(Police/Fire Report ~ 06/17/05)
Cape Girardeau...
Chlora Gilmer
(Obituary ~ 06/17/05)
PARMA, Mo. -- Chlora E. Gilmer, 91, of Parma died Wednesday, June 15, 2005, at Missouri Delta Medical Center in Sikeston, Mo. She was born April 27, 1914, in Formosa, Ark., daughter of Scott and Nettie Jones. She and James Leslie "Jim" Gilmer were married March 25, 1933, in Bragg City, Mo. He died Dec. 30, 1987...
James Purchase
(Obituary ~ 06/17/05)
CAIRO, Ill. -- James W. Purchase, 86, of Cairo died Thursday, June 16, 2005, at Southeast Missouri Hospital in Cape Girardeau. Heavenly Gates Funeral Home is in charge of arrangements.
Doris Kovach
(Obituary ~ 06/17/05)
ANNA, Ill. -- Doris B. Kovach, 81, of Anna died Wednesday, June 15, 2005, at Rehab and Care Center in Murphysboro, Ill. She was born Oct. 3, 1923, in Anna, daughter of Lester M. and Mabel Atchison Broadway. She and Charles K. Kovach were married July 14, 1946, in Jonesboro, Ill. He died June 24, 2004...
Andrea Burford
(Obituary ~ 06/17/05)
BENTON, Mo. -- Andrea Dawn Burford, 16, of Benton died Thursday, June 16, 2005, at St. Louis Children's Hospital. She was born Feb. 7, 1989, in Cape Girardeau, daughter of Paul Edward and Marilyn Ella Brucker Burford. Burford was a junior at Kelly High School and a member of St. Denis Catholic Church...
Speak Out 6/17/05
(Speak Out ~ 06/17/05)
Legacy wall; Time for comeback; Automotive woes; Two key problems; Resource officers; Fighting back; Wealth and well-being
William Wheeler
(Obituary ~ 06/17/05)
William Atrell Wheeler, a 34-year resident of Cape Girardeau, died at Heartland Care and Rehab Center. He lost his battle with lung cancer Wednesday, June 15, 2005, at the age of 80. Bill, as he was known to his many friends and family, was born Feb. 12, 1925, son of Jasper Newton and Mabel Eugenia Davis Wheeler of Moro, Ark. He was one of 11 children; five boys and six girls (Nora, Gladys, Jimmy, Roy, Laverne, Irvin, Ira, Jane, Muriel and Elsie)...
Ida Prosser
(Obituary ~ 06/17/05)
OLIVE BRANCH, Ill. -- Ida Prosser, 94, of Olive Branch died Thursday, June 16, 2005, at Saint Francis Medical Center in Cape Girardeau. She was born Oct. 17, 1910, at Parma, Mo., daughter of James Sidney and Clara Donohoo Porter. She and Vernon "Doc" Prosser were married Nov. 15, 1930. He died Sept. 28, 1993...
James Young
(Obituary ~ 06/17/05)
PERRYVILLE, Mo. -- James K. Young, 83, of Perryville died Tuesday, June 14, 2005, at Scripps Green Hospital in LaJolla, Calif. He was born March 17, 1922, in Perryville, son of Edward C. and Adelheit Palisch Young Sr. He and Marie Tackaberry were married Sept. 2, 1942...
Births 6/17/05
(Births ~ 06/17/05)
DiStefano; Miller; Rhodes; Keeven
Out of the past 6/17/05
(Out of the Past ~ 06/17/05)
25 years ago: June 17, 1980 Slightly more than three years after it opened its doors, the Southeast Missouri Museum on Water Street will close after this weekend's Riverfest. Construction of an alcohol plant along Highway 61 north of Jackson is apparently at a standstill because the Cape Girardeau County Planning Commission hasn't approved the project; Marvin Schoen of Oak Ridge, president of SCH-AGA, Inc., the company developing the plant, says he received approval for the issuance of $751,500 in bonds from the Industrial Development Authority, but the planning commission never gave its approval so that the bonds could be issued.. ...
Artifacts 6/17/05
(Entertainment ~ 06/17/05)
Players looking for living mural interpreters; Tunes at Twilight to feature Stephen Taylor; Cape library to show foreign film Tuesday; Dad Fest this weekend at Tower Rock Winery; All's faire at Cape library Renaissance event; River City Players seek 'A Few Good Men'; Archaeological society show coming to Cape
Connell wins 14-15 division at junior event
(Community Sports ~ 06/17/05)
Southeast Missourian Central High School golfer Jack Connell notched a tournament victory Wednesday in the Gateway PGA/Southeast Missouri junior golf event at Hidden Trails Country Club in Dexter, Mo. Connell topped the 14- and 15-year-old boys tour division with an 84, two shots better than Eric Redfearn...
Limelight memories
(Entertainment ~ 06/17/05)
There was a time, before she sang with the Jerry Ford Orchestra, that Pat Blackwell was joined on stage by two other women, forming a trio that became local celebrities. At each performance, Blackwell, Virginia Hill and Virginia Boren would don their homespun sequined evening gowns and sing the songs of the McGuire Sisters to the beat of a jazz combo...
Monument dedication at Cape park to honor historic band of soldiers
(Local News ~ 06/17/05)
A ceremony dedicating a monument to veterans of the 140th Infantry Regiment of the Missouri Army National Guard will take place at 2 p.m. Saturday at Cape County Park North, near the flagpole. Paying honor and respect to the living and deceased members of the former regiment was foremost in the minds of members of the 140th as early as 1997, when they began meeting every other year for reunions...
State reform; graduating grandchildren; a look at the U.S. Open
(Column ~ 06/17/05)
Serving on Gov. Matt Blunt's State Government Reform Commission has averaged about one meeting a week over the last 12 weeks. It also is requiring a great deal of reading, which is informative and time- consuming. Some of the better recommendations we will make could be easily implemented by a business or industry but will probably take longer for legislative action...
North Koreans need to commit to discussing 'dismantling' nuclear program
(National News ~ 06/17/05)
WASHINGTON -- Secretary of State Condoleezza Rice said Thursday it isn't enough for North Korea to return to six-nation disarmament talks but that it should commit to discuss dismantling its nuclear program. "The ball is in the North Koreans' court," Rice said as she prepared to embark on a weeklong trip to the Middle East and Europe...
Nation briefs 6/17/05
(National News ~ 06/17/05)
'Deep Throat' signs deal for book and movie SAN FRANCISCO -- The man who recently revealed himself as "Deep Throat," the key source for the Washington Post during the Watergate investigation, has agreed to a book and movie deal, his publisher and agent confirmed Thursday. ...
Canadian child killed in Cambodian hostage crisis
(International News ~ 06/17/05)
SIEM REAP, Cambodia -- Masked gunmen seized dozens of children at an international school in northwestern Cambodia on Thursday, killing a 3-year-old Canadian boy. The attackers stormed the Siem Reap International School, grabbing dozens of youngsters and demanding money, weapons and a vehicle in a six-hour standoff. The gunmen killed the boy when authorities declined to meet all of their demands, Cambodian authorities said...
Icons of style on two wheels
(Entertainment ~ 06/17/05)
MEMPHIS, Tenn. -- In the history of motorcycles, some images are enduring: Marlon Brando astride his 1950 Triumph Thunderbird in "The Wild One," or Peter Fonda gripping the ape hangers of his stars-and-stripes Harley chopper in "Easy Rider." But who remembers Lucius Copeland and his revolutionary Star steamer?...
At the theaters 6/17/05
(Entertainment ~ 06/17/05)
'Herbie: Fully Loaded'... Starring Lindsay Lohan, Justin Long, Breckin Meyer, Matt Dillon and Michael Keaton. When Maggie Peyton becomes the new owner of an old Volkswagen Beetle, she discovers the car has a mind of its own. Before long, Maggie is well on her way to taking the old Bug for a spin on the NASCAR circuit...
Jackson gets it right against lefty
(Community Sports ~ 06/17/05)
The local squad roughed up Twin Rivers 12-4. The Jackson American Legion team struggled against left-handed pitching Wednesday night, falling 12-4 to Farmington in the second game of a doubleheader. Jackson had its chance for redemption less than 24 hours later, as Twin Rivers came to Jackson on Thursday for a nine-inning district game. Twin Rivers started lefty Jimmy Cornell, who shined in a complete-game victory against Cape Girardeau last week...
With this ring I thee wed ...
(Column ~ 06/17/05)
Marriage is a serious proposition. I should know. Forty years ago tomorrow I walked down the aisle and said "I do." Maybe I said "I will" too. My memory of the wedding is a bit fuzzy. I do remember that an airplane, probably from nearby Whiteman Air Force Base, broke the sound barrier just as my new brother-in-law hit the high note in "The Lord's Prayer." It would be hard to forget something like that...
A world of song
(Entertainment ~ 06/17/05)
As the lights go down in the River City Yacht Club, eight actors and actresses are waiting anxiously offstage for their turn to go. In the course of the next 90 minutes, each one will be thrust into the glare of the spotlight, going solo in a musical revue with only their own talent and determination -- and a very small budget...
Everybody's a critic: 'Mr. & Mrs. Smith'
(Entertainment ~ 06/17/05)
HH (out of four) Though I really wasn't in any hurry to see this movie, I must say my expectations changed while watching it, from "I think I like it," to "I don't think I like it." Brad Pitt and Angelina Jolie portray a married couple who have no clue what they each do for a living. Not until their respective jobs as assassins place them in the same place and time do things start moving along with more of the plot...
Poll: Movie fans prefer home viewing to big screen
(National News ~ 06/17/05)
LOS ANGELES -- The parking's easy and there are no lines at the concession stand: Most Americans would now rather watch films at home than in theaters, according to an AP-AOL poll. At the same time, almost half think movies are getting worse. Hollywood is in the midst of its longest box-office slump in 20 years, and 2005 is shaping up as the worst year for movie attendance in nearly a decade if theater business continues at the same lackluster rate...
Demand still strong for new home construction
(National News ~ 06/17/05)
WASHINGTON -- The housing market is still booming with construction of new homes rising 0.2 percent in May. Builders rushed to break ground on new projects to meet strong demand fueled by low mortgage rates. ...
Some safer sports-car options
(Column ~ 06/17/05)
Dear Tom and Ray: I have a 1992 Mazda Miata. I'm the original owner and have driven 80,000-plus miles without a repair, if you don't count the electronic antenna getting stuck. I love my Miata. However, out here in Southern California, I figure I am living on borrowed time and will soon get squished by one of the many Hummers, Expeditions and oversized Ford trucks that everyone seems to drive around here (clearly necessary to navigate the daily commute on the freeways!). ...
Stories from Friday, June 17, 2005
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Fasting is good for diabetics, say experts
A senior official from the Ministry of Health said on Sunday that fasting would help diabetics type 2 to regulate their glucose levels.
Speaking in the 'Hello Ramadan' program on Sunday, Dr. Eman Shasha, an endocrinologist, said fasting is beneficial for diabetics type 2 patients. She added that it is not advisable for insulin-dependent patients to fast during the holy month since they are likely to be suffering from other chronic ailments related to diabetes.
The phone-in program, 'Hello Ramadan' was launched last week with its first program entitled 'Your Health in Ramadan' to receive people's inquiries regarding various health problems they encounter during the holy month of Ramadan.
The year, the program is focused on ensuring Muslims maintain a healthy and balanced lifestyle and will stress on the importance of taking prescribed doses of medication in a timely manner during the holy month. The service is available on the toll free number 800 249 4444. It will be operated in Arabic and is open to the public from 1 p.m. to 3 p.m. on weekdays.
A panel of specialist doctors in various fields will take questions from 1 p.m. to 3 p.m. on weekdays throughout the month. The physicians will also interact with the public through social networking sites such as Twitter and Facebook.
"Diabetics in general should follow medical advice strictly when they fast during this month," Shasha said, adding that doctors prescribe the dose of insulin they should take during the non-fasting period. She also explained that diabetics could experience low blood sugar or hypoglycemia during the period of fasting with symptoms including shivering, excessive perspiration, dizziness, and sugar levels dropping to 60 or 70 mg at the beginning of the day.
"In such instances, the person should break their fast immediately. "Diabetics should have small meals frequently between the iftar and suhoor period," she added.
Meanwhile, Mukhtar Khan, who has done extensive research on diabetes and is currently working as a Research Coordinator at the Medical and Rehabilitation Consultancy House, Riyadh, ridiculed the idea that fasting during Ramadan carries health risks for diabetics.
He was referring to an article, "Fasting during Ramadan: The health risks for diabetics" published in the Independent, UK dated July 4, 2014 with questions and answers by Dr. Neesha Patel, a psychologist at Manchester University.
"Fasting is actually beneficial for diabetics, if properly planned with patients being advised by their doctors on dietary management," Dr. Khan said.
He further said, "There are several scientific research works published in journals of international repute, which prove the health benefits of fasting for diabetic patients."
He added that some diabetics who are prone to hypoglycemia, diabetic ketoacidosis and dehydration need close supervision by doctors to avoid any health risks.
Reacting to the article, Akhtar Ul-Islam Nadwi, a Riyadh-based Indian businessman who is also a diabetic, said: "This health risk study by Patel is just scare mongering as I feel more energetic during Ramadan."
Commenting on the part of the article that says a tension often exists among Muslims with diabetes who wish to observe Ramadan in accordance with their faith and the competing need to manage their health he observed that diabetics are well aware of the risks and precautions.
"With my experience, I can say that fasting actually controls diabetes during Ramadan," he said.
In a reply to the long-term risks counted in the article which include mortality, morbidity and reduced quality of life, he said that millions of people have observed fasting safely for more than a thousand years since the advent of Islam. He added that fasting is not meant to create excessive hardships on Muslims.


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Competition: Win tickets to Burnley's Reel Cinema
East Lancashire Newspapers has teamed up with Burnley's Reel Cinema to offer readers the chance to win a pair of film tickets.
We have one pair of tickets to give away this week to see Funny Cow starring Maxine Peake, Paddy Considine and Tony Pitts.
To be in with a chance of winning, just name one of the stars.
Deadline for entries is Tuesday at noon. Tickets are subject to availability.


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- This event has passed.
Adult Art Class- Observe, Practice, and Refine Your Art Skills!
October 13, 2021 @ 1:00 pm - 4:00 pm
An event every week that begins at 1:00 pm on Wednesday, repeating until October 27, 2021
Observe, practice and refine your art skills this fall at the Ogden Museum! Join Museum Educator Mikhayla Harrell for a playful, four-week Adult Art Class inspired by works from artists such as Benny Andrews, Maddie Straton, Bianca Walker and more. You'll also investigate how a practice of mindful contemplation can help you to become a better observer and artist. Then, get ready to dip into collage, painting, sculpture and non-traditional media installation inspired by the Museum's collection and special exhibitions. All supplies provided, just bring your curiosity and a thirst for enhancing your artistic skills! All materials included. Masks required. Questions? Email [email protected].
$150 members / $165 non-members


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The Lifetime Costs of Type 2 Diabetes Can be Reduced by Reversing or Delaying the Progression from PreDiabetes
A recent study has demonstrated for the first time that the lifetime costs of Type 2 diabetes can be reduced substantially with appropriate interventions at the pre-diabetic stage, announced Ethical Alternative Products, supplier of premium grade alpha lipoic acid.
Wyckoff, NJ (PRWEB) August 20, 2013
A new study performed by X. Zhuo, et al. at the Centers for Disease Control and Prevention and reported in the September 2013 issue of the American Journal of Preventive Medicine*, shows that a person with Type 2 diabetes may spend an average of $85,500 to treat the disease and its complications over his or her lifetime. If a man is diagnosed with Type 2 diabetes between the ages of 25 and 44, the expected lifetime costs are $124,700, and for a woman $130,800. Treating complications due to diabetes account for 53% of lifetime costs, with more than half of this cost attributable to damage to large blood vessels, which can lead to coronary heart disease and stroke.
"This is a different approach to a calculation of the costs of diabetes," said Richard Ratner, M.D. chief scientific officer at the American Diabetes Association, quoted in an article in Nephrology News & Issues**. "A better way of doing it is to note that in 2012, in the U.S., we actually had $176 billion in direct medical costs treating people with diabetes," he said. "This is up 40% in five years."
The authors of the CDC study* concluded that effective interventions that prevent or delay type 2 diabetes and diabetic complications might result in substantial long-term savings in healthcare costs. The substantial lifetime medical cost highlights the potential economic return of diabetes prevention. Policymakers have called for additional efforts to prevent type 2 diabetes, particularly among people who are at high risk for developing Type 2 diabetes. Major clinical trials from the U.S. and other countries have established that, among those with elevated glucose levels, structured lifestyle modifications can reduce the risk of developing diabetes by 40%–60%.
A recent article*** in the August 2013 issue of NutraIngredients-US, cites a Frost & Sullivan report indicating that 1 in 3 Americans is expected to develop Type 2 diabetes by 2050, and that foods and supplements targeting pre-diabetics and Type 2 diabetics would appear to have enormous potential. Frost & Sullivan executives stated that: "Solutions are out there, citing alpha lipoic acid (claimed to improve the body's ability to use insulin and lower blood glucose levels), chromium (claimed to help control blood glucose levels), and cinnamon (claimed to enhance insulin signaling pathways and assist with regulating blood glucose levels), but awareness remains low."
"Ethical Alternative Products is in complete agreement with the conclusions reached in the above studies, and believe that our ThioGel product can play a major role in supporting lifestyle changes aimed at halting or reversing the progression from pre-diabetes to Type 2 diabetes," stated Gerald Bruno, Ph.D., CEO and Founder of Ethical Alternative Products. "The high bioavailability ThioGel formulation is unique among commercial alpha lipoic acid products, and has been used successfully by integrative medicine practitioners for more than 10 years," stated Bruno. Ethical Alternative Products is making an effort to increase the awareness of the benefits of supplementing lifestyle changes with high quality and high performance natural products, by making ThioGel solubilized alpha lipoic acid available for a 60-day free trial supply at https://thiogel.com. "While reducing the national burden of healthcare costs associated with diabetes care is an important objective, reducing the individual human toll associated with the devastating consequences of diabetic complications is of far greater importance," stated Bruno.


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RVCA is the brainchild of company Founder and Creative Director, PM Tenore. Transcending the boundaries of traditional action sports apparel, RVCA is a design–driven lifestyle brand free from passing trends. Appearing as natural on the shelves of boutiques as on those of a local skate shop, RVCA is brought together by a group of like–minded individuals from various subcultures, a collaboration of sorts, a lifestyle within itself. PM Tenore's intention from the very beginning has been to create a platform for RVCA which combines art, music, fashion and a modern lifestyle in an original way. At the forefront of this vision has been RVCA's Artist Network Program (ANP) – a venture established to showcase the talents of accomplished as well as unknown artists who inspire our generation and push the boundaries of creative excellence. Established to promote the genuine integrity of RVCA's subcultures while simultaneously giving back to the community, RVCA in essence is redefining the way the market views art and fashion as represented through the balance of opposites and how they coexist: water, oil; air, land; destruction, industrialization; art, science; foreign, domestic; order, anarchy; past, present. For RVCA, it is about today, tomorrow and life as the big picture. It is about inspiring our generation, providing something of substance and culture and above all doing it with integrity and as a united family, a close knit community.
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PTC PIGMENT HOODED LONG SLEEVE TEEReg Price $46.00 Sale Price: $29.99
RVCA MEN'S BIG RVCA SHORT SLEEVE TEEReg Price $30.00 Sale Price: $19.99
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RVCA Men's OPPOSITES 17" ELASTIC 2 TRUNKReg Price $50.00 Sale Price: $39.99