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1. Ed Kilgore has been on a tear exposing the Republican Party's descent into lunacy:
Like a lot of non-Rush-Limbaugh listeners, when I first heard that a large faction of Republican National Committee members was pushing for a formal resolution calling on GOPers to start referring to the Democratic Party as the "Democrat Socialist Party," I thought it was a puerile joke that the adults in the Republican Party would quash.
Apparently not. According to sources speaking to Politico's Roger Simon, the Republican National Committee will approve the resolution at a special meeting of the RNC called for that very purpose.
Here's how the sponsor of the resolution, Jeff Kent from Washington State, explained its rationale a few weeks ago:There is nothing more important for our party than bringing the truth to bear on the Democrats' march to socialism. Just like Ronald Reagan identifying the U.S.S.R. as the evil empire was the beginning of the end to Soviet domination, we believe the American people will reject socialism when they hear the truth about how the Democrats are bankrupting our country and destroying our freedom and liberties. ...
The St. Paul of the "Democrat Socialist" rebranding, Indiana RNC member James Bopp, Jr., sent an encyclical around further explaining its purpose. Here's a pertinent passage:The threat to our country from the Obama administration cannot be underestimated. They are proceeding pell mell to nationalize major industries, to exponentially increase the size, power and intrusiveness of the federal government, to undermine free enterprise and free markets, to raise taxes to a confiscatory level, to strap future generations with enormous unsustainable debt, to debase our currency, to destroy traditional values and embrace a culture of death, and to weaken our national defense and retreat from the war on terror. Unless stopped, we will not recognize our country in a few short years. ...
Comparing the Democratic Party to the leadership of a totalitarian society, and treating it as an enemy of the country, isn't just ridiculous: it's an incitement to crazy people to act crazy or worse.
Good point, Ed Kilgore!
2. Conservatives who have given up on denying climate change have devoted a lot of intellectual effort to obscuring the basic fact that greenhouse gas emissions are an externality that will continue unabated until they are priced into the energy market. Michael Gerson, to his credit, explains the very plain and unavoidable truth:
It is possible that climate change skeptics -- the dominant Republican voices -- have uncovered a vast scientific delusion, like the belief in phlogiston or phrenology. But given the compelling evidence from glaciology, botany and marine biology, this seems unlikely.
Republicans have distinctive contributions to make on climate policy. They might support a carbon tax instead of a cumbersome cap-and-trade system. They should insist that all revenue gained from a carbon tax or the sale of pollution permits go back to the American people in lower taxes. But the main policy choice is binary: Should a cost be imposed on carbon emissions? If Republicans generally say no, they will not be viewed as belonging to an environmental party.
Good point, Michael Gerson!
3. Conor Friedersdorf unpacks conservatism's double standard on internal criticism:
Ms. Lopez concludes by writing that "our time is better spent each doing our part rather than shooting at those who are doing theirs — and successfully." This is a restatement of Ronald Reagan's dictum to never criticize another Republican (never mind that The Gipper didn't actually follow his own commandment). I often wonder, when this is invoked by Rush Limbaugh and Sean Hannity fans in defense of those men, why they never object to criticism of conservatives when it is Mike Huckabee or Ron Paul or John McCain or Colin Powell or David Frum or David Brooks or Ross Douthat or David Dreier or John Boehner being criticized. There is a strange phenomenon on the right whereby it is okay for certain Republicans to be criticized for what amounts to being heretics, whereas it is verboten to criticize other conservatives, because people on the right aren't supposed to snipe at members of their own team. I'd oppose rules like that in any circumstance, but they might make internal sense were consistent characteristics used to determine ideological purity. In fact, one gets to be a conservative who must not be criticized based on some weird standard I cannot figure out, except to say that Rush Limbaugh, Dick Cheney and George W. Bush are all occasionally invoked as guys beyond criticism from fellow right-wingers, so multiple divorces, the idea that the executive possesses unchecked power in wartime, torture, warrantless wiretapping, atrocious immigration proposals and wild deficit spending are apparently not disqualifying factors.
I'd note that the same double standard can be found on the left. Still, good point, Conor Friedersdorf!
4. Ezra Klein analyzes the two strands of conservative opposition to "comparative effectiveness review," which means government researchinto what kinds of medicalinterventions actually make people healthier:
The first is the ideological objection. Some conservatives worry that the "the type of information collected by CER could eventually be used inappropriately if a 'Federal Health Board' was created to decide which types of treatment would be available to whom and when." It's worth parsing this for a moment: The apparent fear here is that the evidence from comparative effectiveness will be, well, used to make treatment decisions. But that can't be quite right. We use evidence all the time. Your insurer won't pay for a leg amputation when your symptom is a headache. Medicare doesn't cover a wheelchair if you're diagnosed with acute constipation. No one whines about that.
The fear, rather, is that the existence of more evidence will somehow qualitative change the way government uses evidence. The government will decree, in other words, that their testing shows back surgery ineffective, and back surgery is now illegal. ...
The industry's fear is quite different: This is the profit objection. Right now, most research on, say, drug effectiveness is funded by the pharmaceutical industry. That presents obvious advantages for them and problems for us. The concern here is that if they cease controlling the flow of evidence, then new studies will show that certain treatments don't work. For instance: Claritin goes off patent. Generic versions emerge. They're very cheap. Claritin's manufacturer changes the chemical composition slightly and comes up with Clarinex. They apply for a new patent. They sell it at a heavy mark-up. But it probably doesn't work much better. If there's credible evidence out there showing that it doesn't work much better, that's the end of that business strategy.
Good point, Ezra Klein!
--Jonathan Chait

subset: commoncrawl


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{SCA} This post is dedicated to nice inspirational quotes and sayings by famous people.
In this post, we have gathered some of the beautiful, unusual and best inspirational quotes text messages.
We are quite sure that you will like this post, So let's get started and don't forget to subscribe to our Newsletter and sharing your comments.
1. Lama Surya Das
Our lack of compassion stems from our inability to see deeply into the nature of things.
2. Author Unknown
Someone remembers, someone cares; your name is whispered in someone's prayers.
3. Michel de Montaigne
When I quote others I do so in order to express my own ideas more clearly.
4. Jorge Luis Borges
Life itself is a quotation.
5. French Proverb
The maxims of men disclose their hearts.
6. William Feather
The wisdom of the wise and the experience of the ages is preserved into perpetuity by a nation's proverbs, fables, folk sayings and quotations.
7. William R. Alger
Proverbs are mental gems gathered in the diamond districts of the mind.
8. Ralph Waldo Emerson
The next thing to saying a good thing yourself, is to quote one.
9. Sophocles
A short saying oft contains much wisdom.
10. Catherine Pulsifer
A quote can change the way you think about challenges you face.
11. William B. Sprague
A collection of rare thoughts is nothing less than a cabinet of intellectual gems.
12. Amos Bronson Alcott
One must be a wise reader to quote wisely and well.
13. Unknown
Proverbs are the cream of a nation's thought.
14. Robert Burns
I pick my favourite quotations and store them in my mind as ready armour, offensive or defensive, amid the struggle of this turbulent existence.
15. Joseph Joubert
Proverbs may be said to be the abridgment of wisdom.
16. Sir J. Mackintosh
Maxims are the condensed good sense of nations.
17. Old Saying
A proverb is the child of experience.


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Many have puzzled over the speed at which time passes – and, in search of a concrete definition, some philosophers have come to the conclusion that it flows at a rate of 'one second per second'.
Not everyone is entirely happy with that seemingly simple explanation however. Take for example Bradford Skow (Associate Professor without tenure at the Massachusetts Institute of Technology). Professor Skow reminds us of the assertion that "… nothing can happen at a rate of one second per second." and explains – "The argument for this conclusion makes no assumptions about what the flow of time consists in. Here is the argument: one second per second is one second divided by one second, and one second divided by one second is the number one. But the number one is not a rate, so is certainly not the rate at which anything (the flow of time included) happens."
The professor thus examines four basic premises :
(Premise 1) If time passes, it passes at a rate of 1 second per second.
(Premise 2) 1 second per second is 1 second divided by 1 second.
(Premise 3) 1 second divided by 1 second is 1.
(Premise 4) The number 1 is not a rate.
Due to the subject's inherent complexities, it's perhaps advisable that those interested in the philosophy time-passage should read the professor's entire paper on the subject in order to attempt a full grasp of its subtleties – one simple phrase, however, does stand out.
"… one second per second is not one second divided by one second."
The paper is scheduled for future publication in the journal Philosophy and Phenomenological Research


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2013: Half! Lightweight with Passion.
Jorge Biosca Martí, 38, has a Mechanical Engineering Degree from the Polytechnic University of Valencia and a Master's Degree in Automotive Design from the University CEU San Pablo, Valencia, Spain.
Biosca is a freelance modeler and design consultant. He works as a Product and transportation design development and consultant, collaborating at the University of Valencia in the "Master in Styling and Conceptual Automotive Design".
Previously, he co-founded Sure Design and was responsible for modeling. Sure Design is a Valencia-based design studio that collaborated with other major design companies for transportation design projects – cars, trains, airplane interiors and electronic goods. He had worked for Fuore Design as a senior modeler as well.
Biosca participated in design competitions: Nov. 2004 participate at the "Tokyo ID Forum" Design in motion and in May 2005, Featured in the "Car Styling Magazine No. 166"
The eLink represents a step forward in efficient mobility. This vehicle will satisfy the everyday higher demand of sustainable products. The elink moves apart from the traditional vehicle architectures. Its simple and symmetric shape creates an iconic and singular look.
The elink is a six-passenger light structure vehicle, with a highly efficient powertrain, combined with an adaptive camber control for tire rubber zone selection.
The main body of the elinK is a pre-stressed structure containing a single outer ring and six tensioners at each side with an additional one in the passenger floor; it has many similitudes with a bike wheel. The tensioners are pre stressed to achieve a rigid assembly with the minimum weight.
The 3m length, 2.5 m high, and 1.95m wide, provides enough room for six passengers.
The elink combines an electric engine, shock absorber and electric steering in a compact mechanism. This four engines and independent steering work seamlessly to satisfy the needs of security and drivability.
The integrated mechanism is connected to the body through a rotational arm that makes possible, combined with the steering articulation, the camber regulation. This camber regulation acts as a tire compound selector. It allows less grip but durability and minimum friction, or higher grip, needed in acceleration, turning or difficult conditions.
Distances became a pleasure to be made, in closed mode for difficult weather and road trips, or open mode for leisure, relax and fun.
With the relatively short length for a six-passenger architecture, the eLink will contribute to reduce traffic and parking problems in busy cities.
Sustainability is not only a trendy value, it has become a need in our lives. We have to be less dependent on energy and planet resources. If we need Half, then we will achieve double.


text:
Pushing it to Extremes
Music Notes
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Songs of the Chesapeake: In Concert and On CD
The Bays soundtrack helps you get your sea legs.
Previewed by Carrie Steele
Bay songs are what Michael Buckley wanted to hear when he started gathering sounds for his five-year-old radio show, Voices of the Chesapeake Bay. His hope was to create a sense of place through stories and music on his weekly series broadcast on 103.1 WRNR-FM Sunday mornings from 7-10am.
Bay songs turned up scarce, and that got him thinking.
Theres a lot of maritime music from New England, says Buckley. Lots of sea chanteys, which are different. They have cadences and are usually sung by many people, because groups of New England watermen were needed to raise the nets. The watermen down here are more solitary.
Thanks to his perseverance, the rare songs of the Chesapeake are what youll hear Feb. 10, when 11 Chesapeake Bay musicians gather on Annapoliss Rams Head Stage.
Before Songs of the Chesapeake could wash ashore, Buckley had to dive down into his musical connections and collections. He surfaced with 16 songs from the watersheds headwaters in New York to Virginia.
This collection is unique because its not all musicians. Some of the songs are the watermen themselves, Buckley said.
Bunkie, David and Jordan Miller, are three generations of watermen from Tilghman Island, who sing Im Just a Waterman, a song written for musical play The Last Waterman, written by Ed Klein of St. Michaels.
Other musicians created songs from Bay experiences that touched them. Robbin Thompsons Chesapeake Moon reflects on sailing by moonlight You have the whole Bay to yourself. Its one of the most beautiful things you can do, Buckley said.
The CD rose from the collection of songs he found for his radio show, as a benefit and as a way for the Chesapeake community to establish a sense of place through music. The CD wouldnt have been possible, Buckley said, without financial backing from Richard Franyo, owner of Boatyard Bar & Grill.
The Songs of the Chesapeake CD benefits Bay non-profits such as Chesapeake Bay Trust, Chesapeake Bay Foundation, the Maryland Watermens Association and Living Classrooms Foundation.
Buckley spent 14 months compiling the CD, reeling in permission from record companies and coordinating design and layout.
The singers, groups and soloists, include both well-known and new artists.
Mike Aiken is a sailor whose recording studio is in the belly of a tugboat docked in Norfolk. His aptly named song, Chesapeake, was recorded in the studio afloat in the Chesapeake.
Them Eastport Oyster Boys, who sing Marina, Marina, are hometown favorites, musical comedians whove found musical ways to tell the Bays contemporary stories of ecology and culture.
Its an eclectic blend of all different kinds of music: folk songs, Celtic and blues, said Buckley. Other songs are soaked with swing, gospel and rock. But the Bays soundtrack stays true to its theme: rockfish, watermen, crabs and plenty of Chesapeake fill this 16-track CD.
At the Feb. 10 show, youll hear Deanna Dove, Dan Haas and Robin Jung, Bruce Myers, Mike Garfinkel, Tom Wisner, Mike Aiken, Them Eastport Oyster Boys, Dominick Murray, The Geckos and guest watermen The Millers.
Songs is partially dedicated to Admiral of the Bay Earl White, a lifelong waterman whose last job was sailing the Chesapeake Bay Foundations skipjack Stanley Norman. He died last year at 86.
Whites voice can be heard on the CD, too, recounting days on the water, and singing ragtime blues.
Its a big world down here in Chesapeake Country, but its also a small world, Buckley said of Songs, which he says strengthens our sense of place. Theres a camaraderie that comes from living around the Bay. To study and understand the place where you live is a great thing.
Songs of the Chesapeake in Concert: Doors open 7pm, show 7:30pm @ Rams Head On Stage, Annapolis. $25: 410-268-4545; www.ramsheadtavern.com. Also at the Avalon Theater in Easton on Sun. Feb. 13, 3pm.


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INSIDE: Zachary Whittenburg on "Floor Show"—a production inspired by the sound and vision of David Bowie
"Floor Show" is an immersive production that draws inspiration from David Bowie's music, career, cultural impact, and more. This one-of-a-kind production—part theater, part live music concert, part dance performance—was created by director Jesse Morgan Young in collaboration with lead performer Alex Grelle and music director Liam Kazar. Here's what choreographer Zachary Whittenburg told us about the production:


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Thomas Winberry
Assistant Professor of Finance, The Wharton School
|Wharton FNCE 6130: Macroeconomics and the Global Environment
This course is an advanced introduction to macroeconomics for MBAs. We will study the aggregate behavior of individuals, households, and firms, and emphasize why this behavior is important for those pursuing careers in business. The applied focus of the course, particularly to the broad business environment, makes it of value even to those students who have taken an intermediate macroeconomics course as an undergraduate, or to students who are considering taking an undergraduate course instead. This course serves as a recommended pre-requisite for most of the advanced business enviornment courses.
Particular topics include: an anlysis of the determinants of GDP (consumption, investment, government spending, and the foreign sector); the determination of inflation, unemployment, interest rates, and exchange rates; the implementation of the effects of monetary and fiscal policy; and the role of technology in economic growth. Throughout, we will focus on the extent to which government policy can or should affect macroeconomic outcomes. Particular examples of policy analysis include: the persistent decline in employment rates during the last decade, minimum wage laws, immigration policy, social security reform, recent Federal reserve policy, income and wealth inequality, federal and state fiscal deficits, the role of taxes in determining labor supply decisions, and why the European monetary union is more fragile than the US monetary union across states.
Chicago Econ 38001 / Booth 33942: Micro Data for Macro Models
(Co-taught with Rohan Kekre) There is tremendous heterogeneity across firms at the micro level; even within narrowly defined sectors, firms vary a lot in their productivity, investment, hiring, and other variables. This part of the course is designed to introduce you to these facts and assess their implications for macroeconomic outcomes. We will emphasize the interaction between empirical evidence – which tells us how firms behave – and quantitative, heterogeneous agent macro models – which tells us how to map that behavior into macroeconomic outcomes. A key question throughout the course is: how does firm heterogeneity change our understanding of the dynamics of aggregate variables, relative to the predictions of representative agent models? We will discuss two broad answers to this question:
1. The dynamics of aggregate variables depend on the entire distribution of heterogeneous firms, which cannot be captured in a representative agent framework.
2. Cross-sectional or panel micro data provides direct evidence on how firms make decisions, and therefore provide valuable information for estimating model parameters not included in aggregate time series data.
Course Background
Syllabus for entire course
Reading List for my half
Guidelines for presentations
Computational Background Material
Introduction to Matlab notes
Introduction to Matlab practice problem
Dynare codes for RBC model
Lecture Slides
Topic 0: Course Intro and Representative Agent Macroeconomics
Topic 1: Productivity Dispersion, Aggregation, and Misallocation
Topic 2: Capital Investment and Adjustment Costs
Topic 3: Financial Frictions and Investment
Topic 4: Firm Lifecycle
Topic 5: Trends in Concentration, Competition, and Markups
Homework 1: Estimating productivity in Compustat
Homework 2: Solving steady state fixed cost model


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Betsy Bender announced the launch of Bender Solutions Group, a consultancy that helps clients differentiate their brand, improve the customer experience and develop their marketing team. Based in Baltimore, Bender, left, will work with clients to build comprehensive brand strategies, and provide interim and advisory chief marketing officer services. "We make our client's job easier, so they can focus on the business," Bender noted in an announcement. "B2C organizations navigating change or wanting to better distinguish themselves will find that our work supports sales, increases customer satisfaction and loyalty, and boosts employee engagement," she explained. For client engagements requiring specialized services, Bender taps the experience of vetted partners. This approach provides clients with best in class expertise and a solutions group assembled specifically for their needs. Prior to launching Bender Solutions Group, Bender was most recently senior vice president of marketing for OneMain. There, she held leadership roles building teams and leading brand management, product development, customer experience and segmentation, consumer insights/research, P.O.S./collateral, direct mail, mass media advertising, and sponsorship.
Columbia-based Maroon PR has been retained by HMC Incorporated to serve as public relations agency of record. HMC, also based in Columbia, is a commercial custom millwork manufacturing firm specializing in custom millwork fabrication, foodservice design, specification and procurement. According to a release, Maroon PR will be working with HMC to lead media relations strategies for the organization, include "executive positioning" for HMC's President and CEO, Kara DiPietro, who acquired the company from her father in 2015.
Ellen Hoover, an account supervisor at Mount Washington agency Siquis until it closed in January, has been hired by the Harvey Agency in Sparks. Also, former Siquis VP and media director Debbie Norris, right, is now media director at HZDG, based in Rockville. Earlier career experience includes media-focused roles at independents Rosenthal Partners (now RP3 Agency) and Eisner Communications. "Debbie's a proven talent. She's got a history of creating engaging, strategic media plans and brings valuable experience to our clients," said Aaron Mushro, director of search and analytics at HZDG. "Her considerable experience adds to our fundamentals as we continue to expand our team. I'm excited to welcome her onboard."
Jellyfish US, a global digital marketing agency with U.S. headquarters in Baltimore, announced the opening of an office in Reston Town Center's RTC West. The new location will serve as the development and tech hub for the digital agency as it continues to grow its East Coast presence and will draw from the strong talent pool in the metro D.C. area. The Reston office, which will house more than 20 Jellyfish employees, currently has five job openings posted. "Jellyfish is a rapidly growing digital agency, and our new office in Reston is ideally situated to draw from a strong talent pool in the metro D.C. area," said Jim Hamilton, managing director and head of U.S. agency at Jellyfish. "Our employees want to be at the epicenter of technology on the east coast." Jellyfish employs nearly 100 people in the U.S. and 350 globally.
Van Eperen, an integrated communications agency specializing in public relations, marketing, social media and digital strategy, announced the hiring of Caterina Ore, a marketing project management professional, to support the firm's growing contract work in Maryland. Fluent in Spanish, Ore brings strategic marketing research, communications planning and project management experience to Van Eperen, supporting accounts in the government and transportation sectors. Also at Van Eperen, account coordinator Debra Buck was promoted to assistant account executive. Van Eperen, a Capitol Communicator sponsor, has offices in North Bethesda and Baltimore.


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ABC Bartending School
San Francisco, CA
If you are 21 years old or older, you could become a professional mixologist with just 40 hours of training!
Convenient Class Schedules to Fit Your Lifestyle
|Course Type
|Times Offered
|2 Weeks - Morning
|Mon. - Thurs., 9 am - 1 pm
|2 Weeks - Afternoon
|Mon. - Thurs., 1 pm - 5 pm
|2 Weeks - Evening
|Mon. - Thurs., 6 pm - 10 pm
|1 Week - Accelerated
|Mon. - Thurs., 9 am - 5 pm
|1 Week - Accelerated
|Mon. - Thurs., 1 pm - 10 pm
|2 Weeks - Weekends
|Sat. & Sun., 10 am - 6 pm
*Adjusted Schedules Available
Our Curriculum Includes:
Job Placement Assistance
Tony Sylvester has been placing bartenders nationally since 1977 and brings to his schools the art of matching the right face to the right place. Take a look at this job placement list for the San Francisco, CA area, and the nationwide chains that have hired our students.
Examples of Bartending Job Placement in San Francisco, CA:
|Thirsty Bear
Club Jazz Nouveau
Studio Z
Condor Sports Lounge
Tony Romas
Shoreline Amphitheatre
Club Zoe
Oaks Card Club
Masse's Nightclub
Commodore Cruises
Mr Pickwicks
Mein Palace
Tito Reys
Cibos Bar & Grill
Monarch Bay Golf
The Carneros Inn
|GT Lounge
The Waiting Room
Doug's Bar & Grill
Suzie Q's
Union Jack Pub
Club Taboo
Chris' Club
Lucca Restaurant


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The Americas region has become the first to successfully eliminate rubella, a contagious viral infection with similar symptoms to measles, health officials announced on Wednesday.
Medical experts are calling the milestone against the endemic transmission of the infection a "historic achievement." Rubella and congenital rubella syndrome (CRS) are now the third and fourth vaccine-preventable diseases to be eliminated in the Americas, following small pox in 1971 and polio in 1994, and experts say it also speaks to the success of a 15-year initiative to provide widespread vaccination against mumps and rubella (MMR) in the area.
"It shows how important it is to make vaccines available even to the remotest corners of our hemisphere," Carissa F. Etienne, Pan American Health Organization/World Health Organization (PAHO/WHO) director, said during a news conference.
Before mass vaccination was available, medical experts say an estimated 16,000 to 20,000 children were born with CRS in Latin America and the Caribbean. The last major endemic cases in the region were in 2009. The virus is usually mild, but it can cause birth defects and miscarriages when women are infected during pregnancy.
Rubella is less contagious and typically less severe than the measles, but health officials say measles is the next target and that many countries have set a goal to eliminate the disease in their borders as well. The U.S. has experienced new clusters of measles outbreaks in the last year, with low vaccination rates blamed among some communities.
Though rubella has been eliminated in the Americas, it's still prevalent in other regions in the world. Dr. Susan E. Reef, the team leader for rubella in the Global Immunization Division at the U.S. Centers for Disease Control and Prevention (CDC), told reporters on Wednesday that the Americas region and the European region are the only two regions that have an official elimination goal for the disease.
"Now that we have achieved this goal," Reef said, "the next step is to continue to maintain it."
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The key focus area of MIYAWAKI Inc. is the manufacturing of steam traps. MIYAWAKI produces all generall types of steam traps: from traditional thermodynamic, thermostatic and float (inverted bucket and ball float) steam traps to advanced in a technical and economical sense temperature control thermostatic steam traps.
The wide range of steam traps produced helps to find the most suitable solution for the customer. All models and connection sizes are available according to JIS, ANSI and DIN standards.


text: Hello All, thought you may be interested by my little webcomic set in Prague. I've had it translated into Czech as well, just follow the relevant links! The link is http://www.theputto.com If you know anyone who may like it please, please send it on (or add on twitter/Facebook). It's taken nearly two years to get off the ground and I want to get the news out! Thanks for reading and I hope you enjoy.


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Spine Surgery Plano TX May Be the Answer for Your Lumbar Pain
If you have chronic lower back pain that does not respond to painkillers or physical therapy, spine surgery Plano TX is an option worth considering. More times than not, pain in the lumbar area is nothing to be worried about. Strained and knotted muscles can cause severe pain, though they usually are not warning signs of anything more serious than overdoing exercise or strenuous physical work. After a few days of taking it easy and resting, that type of lumbar pain should go away on its own, especially if you alternate applying ice and heat to encourage your muscles to loosen up.
Spine Surgery Plano TX: Don't Ignore Lumbar Pain
Though not every twinge in your lower back requires spine surgery Plano TX to alleviate it, that does not mean you should ignore lumbar pain. Web MD points out that there is always a chance that chronic pain in the lower back can be from a torn disc, fractured vertebrae, curvature of the spine, or even from normal wear over the course of your lifetime. Spinal stenosis is another possibility. It is a condition that is typically brought on by osteoarthritis and is characterized by the narrowing of the space around the spinal cord, which places pressure on the cord as well as the nerves, resulting in severe, chronic pain.
Less Common Causes of Lower Back Pain
PainScience.com lists a few less common causes of lumbar pain that are quite serious. Tumors on or close to the spine, infection near the spine, abdominal aneurysm, and a specific type of pinched nerve called cauda equina syndrome are all serious conditions that cause lower back pain. Additionally, even diabetes may cause lumbar pain. Spine surgery may alleviate pain for these issues, but your doctor is the best person to make a diagnosis and provide you with options for treating lumbar pain.
When you experience chronic lower back pain, you should see a specialist. The experienced and skilled physicians at the Brain and Spine Center of Texas have the training and background to pinpoint the cause of your lumbar pain and to treat it in the best way. If the best way happens to be spine surgery Plano TX, the good news is that Dr. Stachniak is a Board Certified M.D. and surgeon who has extensive experience in research as well as hands-on surgical practice using cutting-edge equipment and techniques. Whatever the cause of your chronic lumbar pain, you'll find the help you need at the Brain and Spine Center of Texas. Call (972) 943-9779.
Tags: back surgeon plano tx, lumbar surgery plano tx, spine surgery plano txSpine Surgery Plano TX


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Nut Allergy
Nut allergy is a hypersensitivity to dietary substances from some edible nuts which causes an overreaction of the immune system thereby leading to physical symptoms such as nausea, nettle rash and feeling sick. This type of allergy is treated with antihistamines but it is advisable to avoid the consumption of nuts if you are allergic to them.
- Nut allergy
- Symptoms
- Avoiding all types of notes
- Severe or moderate nut allergies
- Nut free chocolate bars
- Coping with nut allergies
Nut allergy is one of the categories of food allergy. This type of allergic conditions is described as the hypersensitivity of people to dietary products, particularly from nuts, which leads to an overreaction of their body's immune system. When this occurs, the patients notice some severe to mild physical symptoms; some even result in death. The problem with this type of allergy is that the reaction can take place very quickly and in most cases is much more severe than other type of allergies. Because the reaction can be so severe, it is crucial to understand the different symptoms of the allergy. This will help you to know whether or not you are allergic to nuts and also enable you to determine if you are having a reaction. But In most cases, allergy symptoms will require you to seek medical help.
It is important to emphasize that nut allergy is different from a peanut allergy because peanuts are not considered to be part of the nut family. Peanuts are believed to be part of the legumes family, which includes soya beans, lima beans, lentils, and peas. The clear difference between these two conditions is the cause of the allergic reactions. Legumes are known to be the allergens of the peanut allergies while tree nut allergies are often associated with dried fruits. However, these two conditions have similar symptoms, but a person with a peanut allergy is not necessarily allergic to tree nut and vice versa.
If you are allergic to nuts, then you are probably suffering from what is generally known as the contact allergies (some experts call it Type 1 allergy). However, the Asthma and Allergy Foundation of America (AAFA) has estimated that more than 70% of food allergy patients have an allergy to Nuts. Many of the beverages and food processing companies use nuts and Nut oil in food preparations that avoiding them can be very difficult. Thus, there is presently no known cure for allergies that involve food. A lot of individuals that are allergic to Nuts now wear a Medical Alert Bracelet identifying the specific food intolerance.
Anaphylaxis is the most serious symptom of the nut allergy. This is one of the reasons why nut allergies are so dangerous. Although it can also occur with any type of allergy, anaphylaxis found to be much more common with nuts. Since most allergies show mild reactions in most some patients while other types such as allergy to parabens produce serious symptoms in a very small percentage of people, anaphylaxis is the most common reaction in nut allergies. Therefore it is important to know if you are truly allergic to nuts. In most cases, the first indication would be when you have a severe reaction.
As an allergic reaction, anaphylaxis affects the whole body. Once it occurs, a protein called histamine will be released into the body, and this will dilate your blood vessels. This, in turn, causes your body to swell up, and your blood pressure starts dropping to dangerously low levels. People who are allergic to nuts often carry epinephrine pens so that they can administer the treatment immediately they notice the symptoms.
The other most common symptoms are asthma and a rash. Asthma results when an allergic reaction causes your airway to become inflamed. This further makes breathing difficult as the airway has been impaired. Similarly, a rash caused by a nut allergy can occur and spread very quickly. This makes nut allergies to be more severe than other allergy types.
The problem with trying to ascertain whether you are allergic to nuts is that the symptoms for most of the allergies are similar. This is less of an issue with nut allergy symptoms since they are intense and they do react very quickly. Frequently, it is pretty evident that the reaction was caused by nuts. Nevertheless, you can't be too sure until you undergo an allergy test, carried out by your doctor. If you are confirmed to be allergic, he will probably prescribe an epinephrine pen in case you have any reaction.
Allergy to nuts chiefly occurs in children but can also occur in adults. Similar to other allergies, it is best treated by avoiding some of the foods that originate from the source of allergen - particularly nut particles, oils and tree nuts. However, when not treated immediately, it could lead to a severe case of allergies called anaphylaxis (as mentioned above), which requires immediate medical attention and Epinephrine injections.
Avoiding All Types of Nuts
If you are allergic to nut, then it is advisable that you avoid any foods that have been cross contaminated with nuts or foods that contain nuts. Generally, people with severe nut allergy can't risk their food coming in contact with any type of nuts, which means that they only consume foods that were produced in a nut-free environment.
Even if the ingredient doesn't contain nuts or nut products, it is likely that the food has been contaminated because it was produced with the same equipment that made another type of nuts related foods. So, it is important that you look for foods that specifically say "nut-free" in order to be sure it is safe for your consumption. A lot of these brands will include a note on the back of the food with the inscription "Made in a nut free facility."
Severe or moderate Nut Allergies
Since contact with nuts can cause a break out of serious rash in some people or even affects their breathing, individuals who are suffering from nut allergies, either severe or moderate need to be careful about their exposure to nuts. If you are gifting chocolate to your friends with a nut allergy, be sure to buy a brand that is safe for that person to eat.
In addition, with your family and friends, ensure to check the potentials of food allergies so that you can make provision for their food requirements if you are making them a meal or giving them a gift. It is also important to be aware of the food allergies for people around you, to avoid giving them foods that could potentially raise their allergies.
Nut Free Chocolate Bars
Naturally, chocolate is free of nuts, but there are a lot of brands that include nuts to some of their chocolate products. If you are planning to eat chocolate or give it out as a gift, make sure you read the label to ensure that you are buying nut free chocolate bars with a less risk of cross contamination.
To give you the peace of mind and know that you can eat your chocolate without any negative health effects, there are different brands that produce allergy free chocolates to choose from.
Thus, one of the most cost-effective and effective ways to solve nuts allergy is the avoidance of nut-containing foods. Until a cure is known, read the labels of every food that you buy or give out. This is because the production processes change continuously, hence the need to re-read the labels each time you buy a product.
During an allergic attack, several histamines and antibodies are released into the blood stream in an attempt to abrogate the nut protein; known to be the major causes of most food allergies. Why some people overreact to particular proteins is still unclear, and more studies are required for its explanation. Over time, however, food allergies can become worst, and the more times you are exposed to its allergens, the worst the symptom can become.
A lot of over the counter products and common Vitamins can help with Nut Allergies like Glucosamine, Allergy Aid, Quercitin, Vitamin E, Vitamin C, Eucalyptus, and M.S.M.
Coping With Nut Allergies
If you notice that something is wrong with your child, first check the symptoms of nut allergies to check if it has anything to do with what he or she eats. Common symptoms of this allergy include inflammation and hives, skin reactions like rashes, swelling, itching, and eczema.
Otherwise, nut allergies could also cause some gastrointestinal symptoms such as diarrhea, stomach pains, and vomiting. Some severe cases also include loss of breath, nausea, rapid heartbeat, wheezing, running nose and itching around the areas of the mouth.
Consult your doctor for immediate treatment if your child experiences more than four of the above symptoms. While your doctor could prescribe epinephrine injections, it can't cure the allergies for good.
As earlier indicated, the most effective way to avoid these allergies is through monitoring your child's diet. Ensure that all his or her meals, sweets, and other food items do not contain any of the contributing factors of nut allergies.


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Welcome to GovLoop Insights Issue of the Week with Chris Dorobek… where each week, our goal is to find an issue — a person — an idea — then helped define the past 7-days… and we work to find an issue that will also will have an impact on the days, weeks and months ahead. And, as always, we focus on six words: helping you do your job better.
A busy week on GovLoop Insights' DorobekINSIDER…
- We talked about the Digital Government Strategy. Yes, we know many agencies are not flush with extra money to roll out new initiatives. But we spoke to GSA about its role coordinating and bringing folks together to solve problems… to build once and use many times.
- We also talked about BYOD — Bring your own Device. It was a concept that seemed totally… well, let's be honest, it seemed like a pipe dream just a little bit ago. But now it is becoming a reality in some ways… and some are finding that it saves money. The Equal Employment Opportunity Commission is testing it out and we got to talk to that agency's CIO about the challenges and lessons learned.
- We talked about how to be a successful CIO these days. It's not easy. We spoke to Evan McDonnell for his assessment.
- We got to talk about veterans — most people immediately think that veterans are men. But that's changing. There are more and more women among the ranks of veterans and they can need different care. One fed — has made it her mission to remember women veterans.
There were a number of issues that we assessed as we worked to select the GovLoop Insights' Issue of the Week…
This week, we learned a lot about the use of cyber-warfare and cyber-weapons. There has been much talk about the U-S government using cyber-warfare against Iran, and specifically the Stuxnet worm, much of it coming from David Sanger's new book, Confront and Conceal: Obama's Secret Wars and Surprising Use of American Power were warnings from many experts about what the use of those weapons might mean. The man who discovered new new Flame virus this week warned about the use of these tools… weapons. Eugene Kaspersky, the founder of Europe's largest antivirus company, called cyberweapons the most dangerous innovation of this century
This week was also the week of Health Datapalooza, where people gathered to figure out what can be done with all that health data.
The Pew Research reported on the partisan divide in our country — and that divide has enormous implications for government. One of issues that divides us the most: government performance and scope. Click on the image to enlarge it.
The Wisconsin elections took place. And The Washington Post notes that has put public workers in both the fiscal and political bull's eye. From California to Pennsylvania, workers are facing efforts to sharply curtail the job security and benefits they have enjoyed for years, perks long viewed as compensation for the sometimes lower salaries in the public sector.
But our issue of the week... with Memorial Day behind us — it's time to focus on your summer reading list. And your summer reading doesn't just have to be trashy romance novels. You can actually learn something. Tom Fox is the Vice President for Leadership and Innovation at the Partnership for Public Service. He's compiled his list of great summer reading books that focus on leadership ideas, tools and techniques. Tom started off telling us about a book by Colin Powell called, It Worked for Me: In Life and Leadership.
- It Worked for Me: In Life and Leadership by Colin Powell: With his decorated military experience, principled leadership at the Department of State and experience working with both the private and nonprofit sectors, Powell is considered a leadership role model among a large number of the federal leaders and employees whom I have come into contact with over the years. In his book, Powell shares lessons learned from his public service career, including his "Thirteen Rules," which range from "Get mad, then get over it," to "Don't let adverse facts stand in the way of a good decision."
- How Will You Measure Your Life? by Clayton Christensen: Based on his popular Harvard Business Review article, innovation expert Christensen asks readers to answer some deceptively simple questions about fulfilling work, family relationships and ethics that may cause federal managers to reexamine their approach to life at work and at home. To help provide insight, Christensen shares lessons from some of the world's greatest business leaders.
- Start with Why: How Great Leaders Inspire Everyone to Take Action by Simon Sinek: Based on a TED Talk he delivered that went viral, Sinek offers ideas for how leaders can better communicate their vision and connect with their employees. Sinek examines leaders who've had great influence — from Dr. Martin Luther King, Jr. to the Wright Brothers to Steve Jobs — and finds that despite the differences in their times and missions, they all think, act and communicate in the same way. This book can be a great resource for federal leaders who are trying to find classic ways of inspiring their teams and keeping them focused on achieving their agencies' goals and mission.
- Talk Inc.: How Trusted Leaders Use Conversation to Power Their Orga… by Boris Groysberg and Michael Slind: This book provides tips for how leaders can communicate more effectively by making their agency's culture more intimate, interactive, inclusive and intentional. At the heart of the book is the fundamental idea that the power of conversation can help drive employee engagement.
- Immunity to Change: How to Overcome It and Unlock the Potential in … by Robert Kegan and Lisa Lahey: Given the difficult budget environment facing federal managers, you may be struggling with how best to adapt to the changing landscape both personally and organizationally. This book looks at the barriers to fundamental change and why crucial change efforts fail. It offers ways for leaders to overcome their resistance to change and transform both their life and their work.
Weekend Reads:
- What can you learn from the hacker group Anonymous? The author a new book writes in Forbes that says one of the lessons: Be fluid, not formal. Anonymous is a great example of the growth of the leaderless, decentralized organizations. We have a link to the full list — and the book — We Are Anonymous: Inside the Hacker World of LulzSec, Anonymous, and the Global Cyber Insurgency
- Speaking of being innovative, it's not just a challenge for government. It is also a challenge for organizations that you think of as perennially innovation — yes, Google, Apple, Facebook. At the 10th anniversary of the D: All Things Digital conference earlier this month, the old and new slammed up against each other in ways that were both familiar and altogether different. The key dynamic in the tech industry may not be old vs. new. Instead, think old plus new, the Wall Street Journal reports.
- The New York Times Magazine from last weekend — they have 32 Innovations That Will Change Your Tomorrow – It just may spur some interesting thoughts.


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For a few dollars, you too can be like recent Oscar winner Leonardo DiCaprio; at least, that's the sales pitch one Girl Scout troop in New York led with, and if we're honest, don't we all want to live like Leo in his free time?
The Suffolk County, NY troop was inspired by Chris Rock selling Girl Scout Cookies during the Academy Awards, according to ABC News. Their sign:
This is Leo
Leo wants an Oscar
Leo buys Girl Scout Cookies at the Awards
Leo wins an Oscar
Leo is smart
Be like Leo
Hard to argue with that. And then the girls went in for the kill:
"It made people stop at the table to read the sign, and then we were able to ask them to buy cookies. It's hard to say no to a Girl Scout," the troop said. "We thought the photo was funny and would help make people buy cookies."
And their plan worked. It would probably work on us, too. Don't you want to win an Oscar and date the world's models and maybe Rihanna while vacationing on a yacht? Of course you do! Buy some Girl Scout Cookies and get into your new future!
Contact the author at firstname.lastname@example.com.
Image via Getty and Girl Scouts website.


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If you're like most companies and nonprofits, you want to be found. Whether it's potential clients, customers, donors, or volunteers, you want them to be able to find you. And since we're in the 21st century, more and more of those people are using Google and other search engines to look for you.
So how can you ensure they'll be able to find you?
Even if you have a website that was set up properly, often it won't automatically appear in the first page of the search engine's results. If you're not in the first page of results for a particular page, the number of people that will find your site drops off drastically.
A study by Search Engine Watch reveals just how many people click on the different positions in the search engine results.
53 percent go to the top result. The second sees 15 percent of the action, the third 9 percent, the fourth 6 percent, dwindling all the way down to 4 percent to round out the top 5.
Obviously, it's much more likely people will find you if you're in the top five results. 87% of the people stop after the first five, according to the study.
So how do you get into the top five?
Having a well-written blog on your business website can be hugely beneficial, especially when it comes to increasing your ranking on the search engines. In our industry, we call that blogging for SEO.
The only catch is that it needs to be done on a regular basis. And that's where so many people and businesses fail.
Back in 2005, I helped a missionary couple put together a website. They wanted to make sure the members at the churches who sponsored them would be able to find them easily online.
I told them to blog regularly to stay visible on the search engines. So from 2005 until 2009, they blogged several times a month.
After several months of blogging regularly, they started seeing results. And since they continued to blog, those results only got better and better.
In fact, even they came back to the United States in 2009, their website continued to be ranked number one in Google for many relevant phrases for several years.
Maximizing Your Effort
If you do take the time to blog on a regular basis, you'll want to take a few steps to maximize that effort.
How do you do that? By pushing your blog out onto other platforms.
You'll want to set up a page on Facebook, LinkedIn, and an account on Twitter. After those are ready to go, I recommend using twitterfeed.com for automatically pushing your blog out to Twitter, Facebook, and LinkedIn.
When you set up your organization on those social media websites and start updating them regularly, you can actually take up more than one spot on the search engine results.
Write For People
Even when you're blogging for search engines, don't forget that your ultimate target is actual people. Even if you want to rank higher in search engines, that's just a means to an end.
Your ultimate goal is to get people to know, like, trust, and value you. That way, they'll want to buy whatever it is you have to sell.


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HOUSTON, Nov. 26, 2019 /PRNewswire/ -- CNS Pharmaceuticals, Inc. (NASDAQ: CNSP) ("Company"), a biotechnology company specializing in the development of novel treatments for brain tumors, entered into a sublicense agreement with WPD Pharmaceuticals ("WPD"), a Polish corporation partially owned and controlled by Dr. Waldemar Priebe, the founder of the Company. The agreement grants WPD patent rights to research and develop, and manufacture or sell Berubicin in a limited territory comprised mainly of Eastern Europe and Central Asia. The Company is entitled to a 1% royalty on all commercial sales of Berubicin in these licensed territories.
As part of the agreement, WPD committed to a $2.0 million minimum expenditure on the development, testing, regulatory approval, and commercialization of Berubicin during the three year term of the agreement, which ends in August 2021. WPD plans to implement a multicenter pediatric Phase I clinical trial to determine maximum tolerated dose, and to determine the efficacy of Berubicin in Phase IB and II clinical trials in adults. WPD also plans to conduct preclinical tests to determine the prospective use of Berubicin with temozolomide and with other compounds as anticancer drugs.
"We were extremely excited to enter into an agreement with WPD and to further explore the potential of Berubicin as an anthracycline internationally," commented CEO of CNS, John M. Climaco. "Our agreement with WPD is truly a testament to our unrelenting commitment to pursuing treatments for glioblastoma around the world."
About Berubicin Berubicin is an anthracycline, a class of drugs among the most powerful chemotherapy drugs and effective against more types of cancer than any other class of chemotherapeutic agents. Anthracyclines are designed to damage the DNA of targeted cancer cells by interfering with the action of the topoisomerase II, a critical enzyme enabling cell proliferation. Berubicin was developed at the MD Anderson Cancer Center (MDACC), the world's largest cancer research facility. Berubicin appeared to demonstrate one Durable Complete Response in a Phase I human clinical trial conducted by a prior developer.
About CNS Pharmaceuticals Inc. CNS Pharmaceuticals is a biotechnology company specializing in the development of novel treatments for primary and metastatic brain and central nervous system tumors. Its lead candidate Berubicin is for the treatment of glioblastoma, a type of brain cancer currently considered incurable, as well as pancreatic and ovarian cancers, and lymphomas. The Company entered into an IP agreement with Houston Pharmaceuticals, Inc. and a Purchase Agreement with Reata Pharmaceuticals Inc. For more information, visit www.cnspharma.com
Forward-Looking Statements Some of the statements in this release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995, which involve risks and uncertainties. Forward-looking statements in this press release include, without limitation, the ability of WPD to conduct clinical trials to determine the maximum tolerated dose and to determine the efficacy of Berubicin in adults, the ability of WPD to conduct preclinical tests to determine the prospective use of Berubicin with temozolomide and with other compounds as anticancer drugs, and the ability of WPD to spend the required minimum expenditure. These statements relate to future events, future expectations, plans and prospects. Although CNS believes that the expectations reflected in such forward-looking statements are reasonable as of the date made, expectations may prove to have been materially different from the results expressed or implied by such forward-looking statements. CNS has attempted to identify forward-looking statements by terminology including ''believes,'' ''estimates,'' ''anticipates,'' ''expects,'' ''plans,'' ''projects,'' ''intends,'' ''potential,'' ''may,'' ''could,'' ''might,'' ''will,'' ''should,'' ''approximately'' or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. These statements are only predictions and involve known and unknown risks, uncertainties, and other factors, including those discussed under in our SEC filings, including under the heading "Risk Factors" in the Form S-1 we filed with the SEC on October 7, 2019. Any forward-looking statements contained in this release speak only as of its date. CNS undertakes no obligation to update any forward-looking statements contained in this release to reflect events or circumstances occurring after its date or to reflect the occurrence of unanticipated events.
SOURCE CNS Pharmaceuticals, Inc.
Related Links
Source: https://www.prnewswire.com/news-releases/cns-pharmaceuticals-entered-2-0-million-sublicense-agreement-with-wpd-pharmaceuticals-300964958.html


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Pay with a Credit Card:All payments via Visa, Mastercard are accepted.
Pay with PayPal:Make easy, quick and secure purchases through PayPal.
Pay on goods' delivery:Pay the courier's employee upon goods' delivery. This form of payment is applicable for delivering goods in Greek cities only, irrespective of package's weight. Service costs 2.80 €
Pay by bank transfer/e-banking:Pay by transferring the total order value to the following bank account:


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WaterTower Theatre, in partnership with Lone Star Circus, will celebrate the diversity of holidays from around the world through a magical collaboration of theatre and circus with Cirque Holidays! Featuring international stars alongside Dallas' amazing and entertaining circus talent, audiences of all ages will be treated to incredible acts, ranging from hula-hoops to death defying trapeze stunts all tied together with a charismatic host and hilarious clowns. Forget your troubles this holiday season and get ready for a bright tomorrow!
- $0-$41


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Residential Roofing
Recent Projects
For over 18 years, A&E Roofing and Siding, Inc. has provided affordable and quality workmanship to the residential roofing communities across the Chicagoland area.
New Construction – St. Charles IL
New Construction – St. Charles IL
New Construction – Naperville IL
Addition – Wheaton IL
New Construction – Wheaton IL
New Construction – Geneva IL
Our Services
We understand that your home is an important investment. By ensuring our sales staff provides quality information and field expertise, we will work to provide the best solutions to your roofing needs.
For almost 20 years, A&E Roofing and Siding, Inc. has been serving the Chicagoland residential roofing market. Understanding the needs and changes of various steeps-slope roofing applications, A&E Roofing and Siding, Inc. can provide solutions to your homes roofing problems big or small.
Call us now at 1-630-264-1533 with any questions regarding your commercial/industrial roofing project, and a member from our team will be glad to assist you.
- Asphalt Shingles
- Metal Roofing
- Low-Slope roofing systems
- Cedar Shakes
- Synthetic Roofing
Architectural Sheet Metal
A&E Roofing and Siding, Inc. offers a variety of metal solutions to best suit your home or business. Our sheet metal technicians offer experience with metal panel applications, steel, copper, and lightweight aluminum.
By combining skilled craftsmanship, and quality metal products; A&E Roofing and Siding, Inc. can provide you with a long-lasting, and low maintenance metal roof. A&E Roofing and Siding, Inc. provides quality experience and craftsmanship with the following metal applications:
- Standing Seam Metal Roofing
- Corrugated roof/wall panels
- Snow protection systems
- Low-Slope Metal applications (Metal flashing systems, coping, etc.
- Copper/Lightweight aluminum counter flashings
- Gutters and downspouts
High-Quality Brands
ShingleMaster CertainTeed
A&E Roofing & Siding is a SELECT ShingleMaster®, the highest-level credential means that we have met several significant educational and accreditation steps, including having all of our supervisors and at least 50% of our installers being Master Shingle Applicators (MSAs). We also meet insurance and ethical standards set by ShingleMaster.
Mule-Hide Legacy Roofing Contractor
We are a Mule-Hide® Legacy Contractor. Mule-Hide has been trusted in roofing since 1906, staying on top of the latest roofing requirements and solutions , meeting the ever-changing demands of commercial, industrial and institutional buildings.


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2016 Scholarship
Samantha received the scholarship at the June 13th meeting of the Windsor Garden Club. After the award presentation, Samantha discussed her college major with the Club and answered questions about her future plans. The outdoor gathering was well attended by Garden Club members and guests as well as Samantha's parents, Mary and John Dehais.
Pictured, from left to right are: Diane Bernier (current club president), John Dehais, Samantha Dehais, Mary Dehais, Rose Stepnick (club scholarship committee), and Laura Jary (outgoing club president).
One of the Windsor Garden Club's resolutions is to award a scholarship each year to a deserving Windsor student. The scholarship is funded through the Club's annual sale of plants at its Garden Mart in May. Thanks to the many dedicated and hardworking club members, and to all the enthusiastic townspeople who attend our fundraisers and make this scholarship possible.


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InSphero Joins Global Consortium Dedicated to Enhancing Safety Testing of Engineered Nanomaterials
Nanosafety experts from more than 30 institutions convene in Swansea, Wales, for PATROLS project kick off meeting.
Schlieren, Switzerland – February 1, 2018 InSphero AG, the leading supplier of assay-ready 3D cell culture models for accelerating drug discovery and development, today announced that it is participating in a new €12.7m global project under the European Commission's Horizon 2020 initiative and led by Swansea University that will address the need for safer and more effective testing of nanomaterials, an area that is of crucial and growing importance to billion-pound markets including cosmetics, electronics, medicine and food.
The Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment (PATROLS) project involves 24 partners, across Europe, the USA, and Asia with representatives from academia, industry, and Government. The project is coordinated by Shareen Doak, Professor of Genotoxicology & Cancer at Swansea University Medical School, UK, and over the next 3.5 years, the PATROLS scientists aim to establish a battery of innovative, next-generation safety testing tools that more accurately predict adverse effects caused by long-term ENM exposure in humans and the environment. PATROLS launched on January 1, 2018, and on January 29-30, the international consortium, which includes academic, industrial, government, and risk assessment partners involved in the project, attended a conference at the Waterfront Museum, Swansea, Wales, UK to discuss developments and plans.
The Nanotechnology industry promises significant scientific, economic and societal benefits, but commercialization and growth are threatened by safety uncertainties. Exposure to some engineered nanomaterials (ENM) can pose a risk to human and environmental health. However, at present, the test methods used to assess this risk are inadequate and unrealistic. Current test systems utilize scientific models that lack the detail and complexity of the environment and the human body, and only consider the effects of short-term ENM exposure which does not reflect realistic extended or repeated exposure scenarios.
PATROLS aims to address current issues surrounding nanosafety testing by:
- Producing realistic and predictive cultured 3D tissue models of the lung, gastrointestinal tract and liver for ENM safety assessment
- Developing innovative methods for safety assessment in ecologically relevant test systems and organisms, selected according to their position in the food chain.
- Characterizing ENM under relevant experimental conditions dictated by the advanced human and environmental models developed.
- Creating robust computational methods for ENM exposure, dose modeling and hazard prediction.
Professor Doak said, "The cutting-edge models, hazard reporter tests and computational methods developed through PATROLS will allow ENM to be categorized based on their human and environmental risk. The improved predictivity of the tools generated will help to minimize uncertainty in ENM safety. Furthermore, the PATROLS toolbox will provide effective data to support and enhance the current ENM safety evaluation."
As a PATROLS partner, InSphero is using 3D InSight™ Human Liver Microtissues to test toxic effects of engineered nanomaterials. This liver model has already been extensively validated for the assessment of drug induces liver injury (DILI) caused by chemicals and pharmaceuticals. The work performed in the context of PATROLS will further validate the suitability of 3D InSight™ Human Liver Microtissues for liver-related risk assessment of ENMs, which possess a wide variety of different physical, chemical and pharmacodynamic properties. Dr. Wolfgang Moritz, InSphero Head of External Collaborations and IP, said, "PATROLS is an important project with great potential for improving safety testing. We are looking forward to working with the extraordinary team of scientists and nanosafety experts Professor Doak and her team have assembled."
To learn more about InSphero products and services, visit www.insphero.com. To learn more about the PATROLS project, contact Kevin Fernquest, Project Manager – PATROLS Horizon2020.
InSphero contacts
Dr. Frank Junker
Chief Business Officer
Phone +41 44 5150490
[email protected]
Dr. Wolfgang Moritz
Head of External Collaborations and IP
Phone +41 44 5150490
[email protected]
About InSphero
InSphero sets the standard for in vitro testing of novel drugs in the pharmaceutical and biotechnology industry with comprehensive solutions that provide greater confidence in decision making. Its robust and highly physiologically relevant suite of 3D InSight™ Microtissues and Services are used by major pharmaceutical companies worldwide to increase efficiency in drug discovery and safety testing. InSphero patent-pending technologies and methods enable large-scale, reproducible production of scaffold-free 3D microtissues driven solely by cellular self-assembly. The company specializes in delivering assay-ready and custom 3D models derived from liver, pancreas, and tumor tissues, to provide unrivalled biological insight into liver toxicology, metabolic diseases (e.g., diabetes and liver diseases), and oncology (with a focus on immuno-oncology). All InSphero microtissues are thoroughly validated to ensure the highest quality, certified for use in a variety of assays, and shipped globally to customers in a patented, easy-to-use spheroid-optimized platform, ready for research. Field application scientists and research staff with expertise in working with 3D models help ensure efficient integration and onsite training as needed. For customers who prefer an outsourcing strategy with fast turnaround, InSphero also offers contract research services utilizing their 3D microtissue models.
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Hey people! Ms E-Klass is the name and keeping it klassy (yes with a K) is my game! I'm a proud mother of 3 (babysitter anyone), radio/tv personality, and writer.
I'd like to think LL Cool J made "Around The Way Girl" for me because that's me all day! I guess you're wondering where I'm from, right? *Cues Fresh Prince theme music* "In good old Indianapolis, born and raised, by a radio is where I spent most of my days!" No seriously, I stayed listening to my good ol' radio.
I guess you could say it was my destiny, huh?
I got my start in radio in 2007, and I haven't looked back since. Did I mention I was a mom? Of course I did! I'm a proud mom of two boys, and one girl. When you tune in, don't be surprised to catch me talking about them every now & then. Aside from radio, I'm obsessed with Beyoncé, I enjoy anything girly, listening to music, writing, shopping (what lady doesn't), watching romantic comedies n chick flicks, and day dreaming! I'm terrified of shattered glass, and clowns freak me out.
Keep those things far away from me and we'll be best friends! Well, the bell is about to ring because "Klass" is now in session!
Thanks for listening to me on a radio near you, and if you've made it this far, thanks for reading this thing too! Catch you on the airwaves!


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Ski setup
As a bunch of people has asked me over the years about how to mount bindings for backcountry skiing and / or speedriding, here are some thoughts around that topic:
In general non competition speedflying does NOT require any special or specific binding setup other than a good allround offpiste binding setup.
I suggest that the Skis you use should not be too heavy as very heavy skis will have a negative impact on your swingweight when flying "harder" maneuvers (high wingovers, quick left / right transitions, barrel rolls)
Also the skis should not be extremely wide (e.g. 160-140-150) as superwide skis will generate more air-resistance and will slow you down / degrade your glide considerably - espcially when they are not positioned perfectly towards the airflow in barrel rolls or hard turns the air resistance a big pair of planks generates can eventually even become dangerous.
A good mid / shallow sidecut and not too much up to zero camber is a good starting point for selecting your skis.
For an average sized person (say 180cm / 80 kg) something around 170 to 180 cm and 130/90/120 with a sidecut radius somewhere between 16 to 30 meters usually works fine as an allround ski by todays standards (as skis are getting fatter and fatter by the year, dont get fooled, as an allround solution 130mm underfoot wont work too well unless you exclusively ski waistdeep powder - in that case i envy you )
As a binding you usually want to have a touring binding as in most ski areas you might want to be able to easily get away from the populated areas - let alone the possibility for hike + fly style runs (which are often WAY cooler / better compared to runs very close to the ski resort)
Also in many areas after your speedrun you will end up in a side valley or in the middle of a powder field where a touring binding and climbing skins will make it much easier and quicker to get back to the resort and its lifts.
Some Basics you should know
Why bother with Binding setup ? There is a midsole marker on the ski, one on the boot thats it - is it ?
The binding position has a relatively large effect on how a ski feels to you, only 1cm fwd or back can make a very noticable difference mainly in turn initiation, float and rear end grip.
The Standard Mounting points indicated on most skis and boots are NOT necessarily placed in the perfect spot for your body geomtry, instead they will be placed to work for the average skiier (whoever this mhytical person might be) and sometimes obviously in some sort of random fashion by the designers or even production line workers.
Also take into consideration that many manufacturers place the "standard" position in a more hardpack oriented spot, simply because when people test skis (even powder skis) in early season testivals on glaciers etc. in most cases the conditions are not perfect, so a more piste oriented standard setup makes the ski feel better when potential customers test it in non offpiste conditions - so the chances are higher that they like the ski in harder conditions and will buy it. So if (for speedriding) we focus on freeride performance this "standard" position might be suboptimal for our needs.
As an everage ski shop employee usually will not invest much time or thinking in the mounting process unless you specificly tell them to mount off standard) you might end up with a suboptimal setting ... for them (as binding mounting is not really well paid) the focus is mounting time, and the less time it takes them the better.
So even if you NOT want to mount the bindings yourself, it can be very wise to think about the correct position and to mount the bindings TOGETHER with the boots in order to get the right / working boot position.
Be aware that the bootcenter is not always measured in the exact same way by all ski boot mfg's and sometimes it changes from size to size in relation to your foot (as there are usally 2 inner boot sizes but just one outer shell size due to cost restrictions (outer shell molds are very expensive and only justify for the mfg with a big amount of shells molded from them).. so the smaller inner boot will either sit more fwd or more back in the shell (usually more back with some extra padding around the toes in order not to compromise fwd lean adj.)
Also the boot center mark ON THE SKI - as already outlined a few paragraphs above - is placed with a wide variety of intentions (better pow performance, better hardpack perf., easier turn initiation (more fwd)) etc. by the mfg's. so its almost impossible to say what the mfg's designer had truly in mind (i also have personally seen enough pairs where simply the printing had an offset between the two skis so boot center would be 5-10 mm off on both skis of one pair .. an average "high volume" ski shop usually will not look and mount them accordingly off :-o .. ) so its always better to self mount and doublecheck before you (let) drill.
Usually skis mounted for pow / soft snow work best for freeride type speedriding as the more set back binding pos. makes them bite less into the turn (as your foot is further back relative to the sidecut and is not putting as much pressure in the tip of the ski) so making them more forgiving when flying/riding through fast touches in variable snow conditions.
The Art of body related binding positioning
Here is my preferred positioning method, pls be aware that it only works 1:1 for classic non twintipped, mild rockered skis, with twintipped or extremely rockered skis you need to "calculate" (= estimate) a compensation value that factors in the rocker, rocker lenght and the apprx. wheight of the turned up tail portion in correlation to the running lenght - usually you will end up trying a few positions until you get it perfect (too bad that with most touring setups there is no fwd / aft slider like in some carving oriented bindings / race bindings)
Another detail you dont want to overlook ist that with a touring binding setup the skitip should RISE when you lift the ski in touring mode with your leg... otherwise you will have severe troubles in kickturns or when laying tracks in very deep pow
lets have a look at the main steps:
1.) measure the true ski balance of your ski = the point where it balances on itself when placed on a ruler or similar narrow support (perpendicular to the running lenght but i guess thats clear ,-)
A ski with a substantial amount of twintip will balance too far back, so if you balance the ski without compensating for the "tailtip" you might end up with a too far back binding position for general offpiste use (but it might be perfect for deep pow)
2.) put on the skiboot and try to find the point where the middle of the base joint (the one where the toe attaches to the foot) of your big toe is located - best done while lightly "knocking" with e.g. the hard plastic grip of a big screwdriver on the outer shell - you will feel the right point on your foot (i know it sounds weird / funny but its the most precise and the fastest method i know of) ... now you know where your big toe base joint is - mark it on the shell with a felt pen marker.
3.) For a perfectly neutral position on a "classic" ski shape the ski balance and the big toe base joint should line up.
In some (most) cases this and the midsole marker on your boot and the midsole marker on the ski should (hopefully) more or less line up (within +/- 1cm) if you are far off you either have a full on twintip ski (they sometimes have double midsolde markers, one for twintip use, one for normal use) OR you have messed up the ski balance measuring by not correctly adjusting for a larger tail area (twintip tail) or you could have a ski with a weird / unsual wheight distribution, then your only chance is to look at the shape and determine where the ski balance is in relation to the sidecut radius .. it will most likely sit in the flattest part of the (multi)ellypitical shaped sidecut) .. use the mfg's mid sole point on the ski as reference.
remark: for twintipped or highly rockered skis (= the more and more common "exotic" shapes - which does not imply that these shapes are bad - aux contraire some of them work wonders) the correct placement for a given combo of boot / fwd lean / rider biometrics has a lot to do with experience and hence "feel" (and sometimes some luck to get it right on first try).
so be aware that a long / flat ski tip ("early rise tip"), a very short "stubby" tip and / or a very turned up tail (simply anything that has a great impact on running lenght vs overall lenght) will make it more complicated / hard to initially / quickly find the best compromise in binding position especially when you are often traversing from groomed hard slopes to crust or pow.
In this case you have not too much alternatives then to follow the mfg's reccomended midsole position and in a worst case need to redrill / reposition if thats not satisfying.
On Skis that dont come with inserts it might be worthwile to think about putting in threaded steel inserts (e.g. the ones from RAMPA (around 0.30 € per piece)... you need Typ C with 8 mm lenght and 8mm outer diameter and with M5 internal threads (you drill with a 6.5 mm drill and then use the insert to cut the thread in the skis core, glue them in with 24hr epoxy and make sure you dont mess up the M5 threads with epoxy.)
As recommended mounting points can sometimes be so redicoulously off its always good to invest a bit of time and check if they are in a position that at least looks believable / as it would work for your boots and the intended main use (groomers, offpiste hardpack, slush, crud, pow etc.)
That said it can absolutely make sense to slightly fwd mount on powder specific skis to get a more versatile ski that still floats enough in the deep stuff but is more fun on hardpack.
4.) now comes the tricky part: to finally decide where to drill / mount.
At first (important) make sure when you put your boots in full fwd lean your knees are placed OVER the ski balance / basejoint of your big toe area (check this from the apprx. middle of your knee joint to the middle of your bigtoe basejoint with a string and some wheight)..
Pls. dont wank around with this too much, it must roughly meet... some people with very long feet and short lower legs can have trouble here... in those cases you need to go further fwd with your boot realtive to the ski balance line in order to compensate for e.g. very short lower legs...
Also check that your skiboots posess the corrct amount of fwd lean - anything under 18 degrees (some beginner skitouring boots have such too little fwd lean designs) will not work, 21 to 23 degrees are usually a very good compromise (and 99% of all good skitouring boots will have 21-22 degree fwd lean)
ok, apart from that now you should have a solid allround downhill biometric geometry that puts all forces in the right place - the balance point of your foot and ski.
As its absolutely impossible to give general advise regarding mounting positions on different skis, here is a simple real world example of where and why I mounted dynafit bindings on a pair of mt baker superlights (177 lenght if i remember corr.):
For general offpiste use I personally (with my body geometry) never mount forward of the ski balance / big toe basejoint point (= bigtoe base joint more fwd then ski balance) so on my mt baker superlights, after measuring ski balance and finding it 1cm back in relation to the boots midsole markers / the skis printed midsole marker, I estimated that 2cm back over the too much fwd mfg midsole recommendation and 1cm back from ski balance should give me a good allround backcountry setup which should work very well in soft snow and crud and hopefully the ski would still feel neutral enough and not too floaty in the tip for slush and corn.
The expected (and real world) downpoint of this setup (about 1cm back from true ski balance) is that you need to lean a tiny bit fwd (bend your upper body / lower legs an idea fwd from normal) to get full "bite" when skiing fast on icy / artificial snow groomers.
But as i don't like skiing icy groomers and as thats definately NOT the strong point of the relatively light and soft mt baker SL's (i think they re now called the way back by the mfg), so why bother ...
If I would have aimed for superallround i would have gone exactly for ski balance / 1cm back from the mfg's midsole reccomendation.
In real life i was lucky with my guesstimation and my more soft snow oriented setup with 2cm back over midsole (1cm back from true ski balance) showed to be the perfect compromise while keeping the ski very neutral in a veriety of conditions except in bottomless pow which still requires a bit of backward lean to make the tip float (which is no real problem as i then use a different pair of superlight touring skis with 106 underfoot and alot more float in the +130ish tip).
Happy measuring guessing and drilling :-)


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64 Fla. L. Rev. 15 (2012)| | |
With the demise of climate legislation in Congress, and the Supreme Court's rejection of climate-related lawsuits brought under federal common law, rapt attention has turned to the Environmental Protection Agency's (EPA) efforts to bring greenhouse gases into the regulatory fold. Certainly, as the works in this special issue of the Florida Law Review demonstrate, EPA is not the only important player in the climate arena; indeed, as I will reluctantly suggest, the Agency's efforts here appear to be waning rather than waxing. Even so, before turning to other aspects of the problem of climate change, discussed in other works in this issue, it is worth taking stock of where EPA is now, how it came to this point, and how it might proceed from here.
While legal scholarship seeking to assess the impact of litigation on the direction of climate change policy is abundant and growing in leaps and bounds, to date it has relied on and examined only small, isolated pieces of the vast litigation landscape. Without a complete picture of what has and has not been within the sweep of climate change litigation, it is difficult to offer a robust evaluation of the past, present, and future of climate change jurisprudence. Based on a comprehensive empirical study of the status of all (201) climate change litigation matters filed through 2010, this Article is the first to fill those gaps and assess the state of play of climate change in the courts. It concludes that the story of climate change in the courts has not been one of courts forging a new jurisprudence, but rather one of judicial business as usual.
Part I of the Article outlines the scope of climate change litigation, explaining what qualifies as climate change litigation in our study, our methodology for identifying and coding case attributes, and our typology of the claims that have been or likely will be made as climate change moves relentlessly forward. Part II then presents and assesses the major theme revealed from our empirical study and largely missing from commentary on climate change litigation-that a siege-like battle between "pro" and "anti" regulation interests has led to an increasingly robust and complex litigation landscape but with mixed results for both sides. Drawing from those findings, Part III takes on a set of empirical and normative questions designed to summarize and assess the climate change litigation experience and its impacts on the content and institutions of climate policy. It is evident at all levels of inquiry that courts have taken a "business as usual" approach to climate change, resisting litigants' attempts to make courts a locus of direct policymaking, but courts nevertheless have influenced the policy content and its institutional contours dramatically. We extract these themes from the full experience of climate change litigation and suggest fruitful paths of research to develop a better understanding of the role and impact of the courts in the climate change policy arena. Part IV then stretches a bit from the confines of our empirical study and findings to speculate about the future of climate change litigation.
David Markell and J.B. Ruhl, An Empirical Assessment of Climate Change In The Courts: A New Jurisprudence Or Business As Usual?
64 Fla. L. Rev. 15 (2012)| | |


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You know what would happen if you made a real Death Star? And how many humans do you need to grow in tubes to power a robot society like in the Matrix? Stories can function perfectly well without proper math. However, making the correct calculations can enrich stories a lot.
A story of bodies
Let's start with an example from my own writing.
In my short story Hostages, and my (unpublished) novel Aperture in the same universe, a race of alien parasites breeds humans to use as hosts.
Initially, my idea was that the parasites would have roughly 3,000 worlds, and two breeding worlds where they bred humans. Humans would be processed and shipped out to be used as hosts when their brain matured, at twenty-five. Sounds reasonable, right? Well, numerically speaking, anyway.
Enter math. Let's do some back-of-a-napkin calculations. The aliens don't want an advanced society, to prevent uprisings. They don't want to overstress the environment either. However, on an Earth-sized planet, even supported by advanced alien technology, that means you can't have more than three billion people or so. With a processing age of twenty-five, that means you'd be able to ship around 100 million bodies per year, tops. And that's assuming you could even get the logistics for that to work – you'd have to ship out over two-hundred thousand bodies a day.
Okay, interesting math, but so what? Well, aliens will want to switch to new hosts when they start to show wear and tear. For a human body that's around fifty – let's assume good gene tweaking and a clean environment. That's twenty-five years of use, meaning you can support roughly as many alien parasites per year as you have humans. Oops, 3,000 alien worlds supported by 2 human breeding worlds isn't going to work, then, at all.
It turns out, I needed many worlds to support the host-hunger of my alien population. So, that had to change, and it gave me the idea of introducing various different host species provided by large corporations that the aliens could choose from like we would choose our cars.
Death stars and Matrix robots
So, what if we start to apply math to some of our favorite movies?
First up, the Death Star. Well, just about everything about the Death Star is a mess. How is it powered? What material is it made from that makes it not collapse in on itself? Where does gravity come from? How much food has to be shipped in each day, and where does the waste heat go? Well, people have discussed all this, but have come to no satisfying conclusion.
If you look at the planet Coruscant — you know, the planet-sized city where the Emperor lives — that has some problems of its own, mostly with waste heat. This would apply to any city-worlds, in fact, like for example Ravnica from Magic: The Gathering.
Next up, the Matrix. The idea behind the movie is that AI robots have taken over Earth. During the AI-human war, the humans blocked out all sunlight to prevent the robots from getting enough solar power, and so the robots started using humans in tubes to power themselves. The idea is cool, but how many humans would you need?
Well, the answer is actually quite simple: the laws of entropy and thermodynamics means growing a human body and keeping it alive requires more energy than you're going to ever harvest from it. Feeding humans the remains of other dead humans won't help to balance out the equation. It's a planet-sized perpetuum mobile, and it can't work. Oops.
Does this matter?
The short of it: no, not really. The Matrix and Star Wars did pretty well despite the flawed science and math. You can pave over a lot with good writing and believable characters.
However, there are risks. You can pave over the math, as long as your story doesn't hinge on it. Star Wars established very clearly that the Death Star was a very dangerous weapon and that it could be destroyed with a missile through a ventilation duct. So, the science was bad, but the rules were clear enough and not too obviously nonsensical.
Also, making obvious math errors can be really glaring for those who know what they're talking about. The more glaring the error, the more readers you're going to lose. Imagine writing a story where the protagonist from current day Earth is whisked away to a 15 billion year old star… while the universe is only 14 billion years old.
Contrast that to the Matrix 2. In the second Matrix movie — minor spoiler — it turns out that Neo has special powers outside of the Matrix. It is never really explained why this is. The third Matrix movie sort of pushes Neo onto the pedestal of being the new Christ and that's it. Which is why it didn't work. You can fudge, but not on rules that the plot hinges on. That will make it feel like a deus ex machina.
Mess up your math at your own peril. If your plot hinges on a certain thing, make sure the math and science are right, or make sure you explain the rules clearly.
And, you can use math and science when world-building to make your world both more believable, and far more interesting. Creative solutions make things better than a hand-wave, because the hand-wave is the lazy way out.
Happy writing.