text: Working a small enterprise requires superior problem- fixing and a capability to have a look at the larger image. Other than making certain that your corporation turns a revenue regularly, you additionally must be involved with your individual monetary well being over the long-term. That features having a method in place for constructing wealth, so you'll be able to get pleasure from a cushty retirement as soon as the time comes at hand over the reins of your corporation to another person. As an entrepreneur, there are particular hurdles you ought to be ready for that may hinder your capacity to create wealth. (For an in depth rundown, see? Investigator's tutorial Beginning a Small Enterprise.) Listed below are 4 vital challenges small enterprise homeowners face.1. Too A lot Enterprise DebtGetting a small enterprise off the bottom usually requires a sure amount of money. Taking out a time period mortgage from a financial institution or a Small Enterprise Administration (SBA) mortgage often is the reply, if you do not have sizable financial savings you'll be able to faucet into. With a 7 SBA mortgage, for instance, it is attainable to borrow as much as $5 million to determine a brand new enterprise.Even if you happen to do not want a mortgage to get began, that does not imply your corporation will – or ought to stay debt-free. As an illustration, you might resolve to open a enterprise bank card to earn rewards on day-to-day bills or take a service provider money advance to assist cowl your money circulation throughout slower intervals. Or you might need to borrow to increase, particularly if the enterprise is doing properly. Whereas bank cards, advances and loans will be invaluable to preserving the enterprise operating, their comfort comes at a value.If a considerable a part of your corporation' income goes towards repaying its money owed, that leaves much less earnings to commit to development. It additionally leaves you, because the enterprise proprietor, much less cash to funnel right into a solo 401(okay), SEP IRA or related certified retirement plan to make sure your individual future. Whereas the curiosity on a small enterprise mortgage, the funds themselves aren't. Paying down your corporation money owed permits you to redirect funds towards your retirement or a taxable brokerage account as an alternative.2. An Inefficient Tax StrategyAs a small enterprise proprietor, submitting and paying taxes could also be some of the disagreeable duties in your to-do listing, nevertheless it's a necessity. Should you're not making the most of each obtainable tax break, your wealth with out even realizing it. There are a selection of tax credit deductions that you could declare on your corporation or private tax return? An expense have to be deemed each odd and vital. This implies the expense have to be one thing that is generally related to the kind of enterprise you personal and immediately related to its operation.When you do not take the time to maximise each attainable tax benefit, the result's a very massive tax cost. Hiring an accountant to handle your submitting might enhance your corporation bills barely, however it may additionally assist to reduce your tax legal responsibility. By way of constructing wealth, the long-term profit can simply outweigh the fee.3. Lack of DiversificationBeing a enterprise proprietor requires a specific amount of juggling, and also you merely might not have time to pay as a lot consideration to your investments as you would like. The scale of your property impacts your general monetary standing, together with how banks see you, particularly if you happen to're a sole proprietor. Investing in mutual funds or exchange-traded funds, eliminates the effort of attempting to place collectively a well-rounded portfolio, however it may be problematic if the funds you are buying maintain the identical underlying securities.Enterprise homeowners can even run into points if they don't seem to be rebalancing periodically. That is very important to make sure that you are sustaining the appropriate asset allocation, primarily based in your funding targets and threat tolerance. Should you do not rebalance often, you could possibly find yourself with a portfolio that is both too aggressive or too conservative. At one finish of the dimensions, you run the danger of dropping cash by playing too closely on shares. On the other facet of the spectrum, you threat limiting your earnings potential if you happen to're taking part in it protected with an abundance of bonds. Both approach you are placing your future returns in jeopardy by not listening to the extent of diversification in your portfolio.4. Exterior RisksAside from managing market threat, you additionally must be cautious about insulating your self and your corporation from threats that will come up in different areas. As an illustration, what would occur to the enterprise if you happen to had been to grow to be unwell and will not oversee its operation? How would your corporation and private property be protected if your corporation turned the goal of a lawsuit? What would you do if your corporation was broken by a hurricane or different pure catastrophe?These are the sorts of questions small enterprise homeowners should contemplate, as a result of though such situations could seem unlikely, they will have a considerable influence on the way you develop wealth. Selecting the suitable enterprise construction is a crucial step in minimizing legal responsibility, however you also needs to be proactive in reviewing your corporation and private insurance coverage protection to make sure that you are protected in opposition to each chance.


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Apple has taken the tablet world by storm, there is no doubt that they have dominated a market and to this day, face little competition in the marketplace. While the Samsung Tab does offer solid competition, the jury is still out about if it will stand the long term test and truly put pressure on Apple's marketshare.
Vouchercodes.co.uk recently conducted a survey of 3000 individuals regarding tablets and has released their results. Not surprisingly Apple has come out on top for brand trust and awareness with Dell coming in second and RIM following closely behind Dell to take the third place position.
So what does the infographic tell us? It's clear that Apple has the brand recognition and trust behind its name and that other companies lag severely in this area. Other than the obvious that Apple dominates the market, we can also understand that most people want a tablet for surfing the web, social media, and to watch videos.

subset: commoncrawl


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With a comfortable, lush yard and simple, elegant landscaping to welcome you home, this sunny rambler has great curb appeal and makes a charming first impression. The ideal place for simple, easy living, this Cape Cod retreat comes with the just the right conveniences: timeless hardwood floors, a large detached garage, a fully-fenced yard, and appliances included. At a cozy 780 sq. ft., this single-story home's 2 bedrooms and 1 bathroom make it the perfect space for those who appreciate an intimate, uncluttered lifestyle. Located at 838 S Macarthur St, Tacoma WA 98465, this home is listed for $235,000.
This classic rambler has plenty of room both inside and out for comfortable and cozy living. In the main living area, large windows on every wall let in ample natural light and a modern, open-concept floor plan promises to make this space the center of daily life. A simple, contemporary color palette shines the spotlight on sleek floors and magazine-inspired design elements.
Adjacent to the living space sits the bright kitchen, where you'll find room for a dining nook along with stylish bar-style seating at the counter. Crisp, white cabinetry is highlighted by elegant recessed lighting, offering both convenience and a classic aesthetic. Versatile finishes ensure you'll be able personalize the space with your own decor to create your ideal home-sweet-home. Enjoy a laid-back cup of coffee on Sunday or have a friend over for a glass of wine – this relaxed scene offers the ideal setting.
Down the hall, you'll find the home's two generous bedrooms, each brightened by plenty of windows and offering both privacy and versatility. Consider transforming one of them into an exercise room, office, etc. The possibilities are endless! The potential for another bonus room awaits in the ~300-sq.-ft. detached outbuilding as well. Brimming with potential, this unit could become a guest suite or private studio – envision having your very own artistic space, or even hosting band practice? There's room for it all!
This property's outdoor spaces cater to those with an adventurous spirit. The large backyard patio opens into a potential sport court area. Transform the patio with some outdoor furniture, a couple of flower baskets, and a barbecue, and you'll be ready to host weekend get-togethers all summer long! The sport court is just waiting for a basketball hoop, offering plenty of room for little ones to play in the comfort and safety of home. Plus, garden boxes await your green thumb—imagine having your very own garden that's overflowing with beautiful flowers and fresh fruits and veggies!
Living in Tacoma
At 838 S Macarthur St Tacoma WA 98465, you're surrounded by commuting options, shops, restaurants, outdoor opportunities, and more! Highway 16 is a short 3-minute drive away, making it quick and easy to get to Interstate-5. Find easy access to transit options on 6th Ave and S Mildred St as well. You'll find plenty of shopping, restaurants, and services nestled along 6th Ave, which is conveniently just 2 blocks from home. Head south for just a few minutes and you'll find places like Fred Meyer, Rite Aid, Planet Fitness, and several other shops and eateries as well.
Interested in learning more? Click here to view the full listing! You can also contact REALTOR® Pat Busick online here or give her a call/text at (253) 732-8750.


text: Registered Nurse – Perioperative Nurse - Operating Room Job ID: 933085 Discipline: Registered Nurse Specialty: OR Date Posted: October 03, 2023 Address: 989 Medical Park Dr Location: Maysville, KY 41056 Shift: 8 D Duration: 13 Weeks Start Date: October 30, 2023 Company: Onward Employment Type: Temporary Weekly Pay: $1,087 - $1,198* *Estimate of weekly payments is intended for informational purposes and includes hourly wages, as well as reimbursements for meal & incidental expenses and housing expenses incurred on behalf of the Company. Please speak with your Recruiter for additional details. Job Description & Requirements Registered Nurse – Perioperative Nurse - Operating Room Featuring advanced technology in addition to compassionate care, this esteemed Operating Room (OR) unit is looking to welcome a new member to its nursing team. Innovative care teams deliver optimal care to their patients at this cutting-edge facility. You can expect to work on complex cases with a driven team of passionate Operating Room (OR) professionals, utilizing the best patient care models. Required Qualifications Years of Experience: 2. 1. RN license (#, exp.) 2 BLS, ACLS 3. SSN/DOB Job Benefits AMN Healthcare's travel nursing assignments typically last 13 weeks, and include: Competitive pay rates and comprehensive benefits Medical plans with dental and vision Complimentary, high-quality private housing 401(k) and flex spending options Life insurance Accident and short-term disability coverage Free continuing education (CE) courses Travel allowances Guaranteed pay program Tuition discount program Referral bonuses About The Company Onward Healthcare, an AMN Healthcare company, is a travel nursing company dedicated to moving our nurses careers "onward and upward." Our team of expert recruiters connect clinicians with exclusive travel nursing opportunities at the nation's top hospitals and healthcare facilities. Onward's nursing assignments are part of a larger, comprehensive RN career development and consultation service. Onward/AMN Healthcare is an EEO/AA/Disability/Protected Veteran Employer.


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Authentic Navajo rug, Storm pattern, weaver Samatha Yazzie, 25″ x 36″, $937
warps 9
average wefts 44
Superior value and weave, particularly appealing color arrangements and intricate designs, tightly woven with clear distinct lines.
This newly handwoven Storm pattern Navajo rug is 100% wool. The weaver, Samatha Yazzie of Dalton Pass NM, is a member of the Navajo Rug Weavers Association, and the rug includes the Navajo Rug Weavers Association Certificate of Genuineness.
The Storm pattern was accepted as a Navajo rug weaving style in the 1950's. Typically bordered Navajo rugs rendered in black, white, gray and red color combinations, Storm is a distinctive pattern originating in the Tuba City area or western half of the Navajo Indian reservation. Basic features in the pattern of Storm Navajo rugs include a center box or square, which is described as a hogan or center of the world; smaller boxes at or near each corner of the rug, called houses of the wind or sacred mountain; and four zigzagged lines representing lightning, connecting the center square to each smaller corner box. Two figures, symbolizing water bugs or pinon beetles lie at center top and bottom of these Navajo rugs.


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In My Shoes by Adrian
About The Author...
Adrian Stephens was born in southern California, but has lived most of his life in Las Vegas, NV, where he currently resides with his wife, Cristy, and two children, Bailey and Brendan.
Other Books By Adrian
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All flats are fitted with a fully equipped kitchenette with cooker, refrigerator and microwave. Here you can see an overview of our spacious and comfortable holiday apartments.
In the bungalow in the middle, you will find the:
In the building on the left, you will find the:
Holiday flat Kirschengrund****


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I'm always excited to find a new restaurant close to work, and thanks to fellow foodie blogger Crystal, I did the other day. She invited me to lunch at Scratch on Brecksville Road in Independence.
It's quite cute inside, like this sign on the back wall.
I went for the Ultimate BLT with smoked pork belly (really just thick cut bacon), lettuce, tomato, and a pepper aioli on toasted multi grain bread ($6.95). Dining Deals Alert!
We sat and chatted for quite some time after the meal, and the staff went above and beyond to be accommodating (even offering complimentary coffee).
They are still getting their groove on menu items, but I think it has real potential. I'll be scheduling some working breakfast or lunch meetings here in the future.
6595 Brecksville Rd. #1
Independence, OH 44131


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Chad Johnson is a complicated man. The NFL's most infamous loudmouth is actually an introvert. He has 4 million Twitter followers, but mostly hangs out alone. He's a ladies' man, but now claims to be celibate. He listens to Andrea Bocelli and is addicted to ChapStick. He is an enigma, wrapped in Urban Outfitters, and doused in David's Café.
But if there is one thing that confuses people most about Johnson, it's his fascination with killer whales.
After hanging out for a day with Ochocinco at Miami Seaquarium, we can finally explain his orca obsession.
See also: Chad Johnson's Comeback: A Year After His Career Imploded, Orcas and Instagram Fill the Void
Johnson has either tweeted or been tweeted about orcas more than 1,400 times in the past month. It is safe to say that nobody has been this fascinated by killer whales since Free Willy.
Sometimes, his Twitter followers complain of orca overload. But Johnson keeps bombarding them with tweets about the animals, like the fact that there three types of orcas, all of which have different diets. Or that they've never killed a human in the wild.
Fifa/Call of Duty/Orcas RT @NellyD15: @ochocinco you don't drink or have sex, what the hell you do for fun then?— Chad Johnson (@ochocinco) August 14, 2013
So why is Johnson so obsessed with orcas? We went to the Seaquarium with him to find out.
Sitting in the bleachers before the show, Johnson said that he sometimes comes here three times a week. Orcas are his escape, he said. His grandmother, Bessie Mae Flowers, first took him to the Seaquarium when he was 7 or 8 years old. He was a kid from the concrete streets of Liberty City who had never seen wildlife. "She was the first thing I ever saw that was outside the norm of what I was used to," he says of Lolita.
He also feels an affinity with the animals. As the show begins, the similarity between the man and his orca become apparent. Lolita explodes from the water 20 feet into the air on command, not unlike Johnson catching a pass after a huddle.
Fast and powerful, both have spent their lives performing athletic tricks for strangers. Both are too smart for their own good. And both can be dangerous. (Johnson pleaded no contest to domestic battery last year. In 2010, an orca killed its trainer at SeaWorld.)
It was only after the show, however, that we really saw Johnson's deep connection to orcas. He initially tried proposing to Lolita's trainer, Heather Kennan. When he found out that she was married, he settled for a kiss from the killer whale herself.
After planting his lips on the 7,000-pound whale's tongue, Johnson jumped up as if celebrating a touchdown.
"I don't need a woman when I'm tonguing a killer whale," he said. "My life is made. If I could have gotten into the water with her, I would have died and gone to heaven."
"The whale's tongue tasted like oysters," he added. We headed straight towards the Seaquarium gift shop.
"Mr. Johnson, can I get a photo?" asked a gangly kid behind the counter. Johnson didn't skip a beat.
"Sure, if you show me all the killer whale stuff you've got," he said.
Johnson grabbed a giant, plush Lolita doll and two glass orca sculptures. The total damage: $284.87. I asked him if they were gifts for his four kids.
"Hell no, these are for me," he answered. (Sure enough, the doll now adorns his bed and the sculptures are on his coffee table, near his NFL helmets.)
Later, Johnson explained why he doesn't care what people think of his orca obsession -- or anything else about him, for that matter.
"I've been a weirdo since high school," he said. "When I was at Santa Monica Junior college in 1996, 1997, I took classical class, jazz class, opera class, all those are part of my credits. Those are the classes I actually went to."
"Most athletes feel they have to be politically correct," he continued. "It's all about eyeball. They want to be perceived in a certain way. And there is a certain acceptance from their peers, from those who employ them, to say: 'Look, I'm doing it your way. I'm doing what you want.'
I love Orcas and now @Cristiano loves Orcas ⚽ pic.twitter.com/0S8V63V3Rw— Chad Johnson (@ochocinco) August 7, 2013
"Nah. This is me. I want you to like me for me being who I am, not because I am pretending to be someone else to appease you," he said.
His comfort with being weird comes from "trying to please people and them never being happy... knowing that no matter what you do, it's never enough. I don't know at what point I got over it and said, 'Fuck it, I'm just going to be me.'
"There are three types of people in the world: people who are going to love you no matter what you do wrong; people who are going to hate you no matter what you do right; and those people in the middle who just don't give two shits no matter what the fuck."
When he's not working out in the hopes that an NFL will give him one more shot, Johnson spends his afternoons sitting at either The Pelican Hotel or David's Café in South Beach. The spots are perfect -- well, nearly. He can think of one way to improve them.
"Dude, I want to own a restaurant where you can sit amongst killer whales," he says. "You know what I'm saying? I'm talking about a huge tank. Do you know how peaceful that would be?
"Five star restaurant, dim lights, surrounded by fucking orcas," he says softly. "That would be fucking fascinating."
Follow Miami New Times on Facebook and Twitter @MiamiNewTimes.


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Root River Triathlon
Root River Triathlon
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Sat, May 16, 2020
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Houston, United States
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111 E Cedar St, Houston, MN 55943, USA
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How did you hear about the Leadership Academy and what inspired you to apply for the program?
I found out about the Leadership Academy when I first began volunteering with Latino Outdoors in Los Angeles. I went to a mixer in Pasadena and met some amazing folks from SGMF who were doing great things for the San Gabriel National Monument and furthering the expansion of the National Monument. I was inspired to apply to learn more about community engagement and seeking better recreation and access for underserved communities in Los Angeles.
What is your project?
The Abilities Project is a civic outdoor education access project though the Leadership Academy — connecting individuals with disabilities to green and open spaces and providing an interactive and educational hike in the San Gabriel Mountains. Disabled people will learn about the history, wildlife, environmental justice, and the importance of civic engagement in protecting access to the San Gabriel Mountain National Monument for their community and beyond.
The first event will take place during the month of October during Disability Awareness Month. October is also the same month that President Obama designated the San Gabriel Mountains a national monument. I wanted to make this first event important and memorable. There's still as lot of work to be done.
The Abilities Project's long term goal is to develop and launch a website and app to help Disabled People connect to green and open spaces in the city or outdoors and to connect to programs and organizations that provide resources and services. The app will create a platform for Disabled People, families, service workers/providers, and transform the way communities come together and advocate for access and recreation through technology.
What's the best thing you learned?
While in the Leadership Academy, I learned many things. I can't really pin point the best thing I learned because every class was different and in my opinion very important. I highly recommend applying to the SGMF Leadership Academy. It will change your life.
What surprised you about the program or your work on the project?
I was surprised about how much I had to learn about community engagement, fundraising, and storytelling. It made an impact on my life in a short amount of time. It helped nurture a passion of mine that was kept in my head for such a long time. And now I am slowly but surely working on making it a reality.
Describe what being in the great outdoors means to you.
Being in the great outdoors is a way to connect and heal with oneself. To breathe in fresh air. To get lost in the sounds, smells, vibrations mother nature gives. For me it's about hitting the trail or rock climbing. It's about protecting the wildlife that call the great outdoors their home. I find peace when I enter this space and I want others to experience it in their own way.
What's your favorite way to spend your day in the San Gabriel Mountains?
I have so much to learn about the National Monument and its different terrain. I will say my favorite is rock climbing at Horse Flats Campground. I just started trial running again and I am looking forward to running on trails in the San Gabriel Mountains.
What has post-academy life been like?
It has been exciting and exceptionally busy! Doors are opening for the right reasons. I've got a world to change and it's very humbling and exciting process! My role in Latino Outdoors is changing and there's room for opportunity if anyone in the Los Angeles area is interested. I recently was picked to be a part of the SHIFTjh Emerging Leaders Program and slowly making moves for the Abilities Project. While at the 2017 Summer Outdoor Retailer in Salt Lake City, UT, I marched on behalf of protecting public lands. I support and help in any way I can to provide volunteer time for organizations like Access Fund, Wilderness Society, and SGMF who are doing great work to get the word out to their communities on how important our National Monuments are to all of us. I hope that more people join the movement and become lifelong constituents. Being pulled in many directions is hard, but at the same time I'm hoping that the long hours and dedication pays off.


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In these unexpected times where the country is facing simultaneous health and economic challenges, Lodha Group is working to ensure that our people and business emerge strong from this crisis. Here are few initiatives that we have undertaken to lessen the troubles of those whose lives have been impacted owing to the lockdown.
For our workforce
Being India's largest real estate developer, we employ over thousands of people. We have undertaken special initiatives for our contract workers and employees to help them combat the implications of lockdown.
Contract workers and daily wage earners are the most affected during these times with no source of livelihood or access to food and basic amenities. We have ensured that sufficient food supply arrangements are in place for tens of thousands of workers who are currently staying at our sites. Simultaneously, we are also ensuring their medical welfare.
Further, we have also provided advance salaries for the month of March 2020 to all our employees from lower to mid management level, so that they can take good care of their daily needs and families in such scenario.
For our retail partners
Adhering to the closing of premises that have large public gatherings; retailers including malls (excluding essential services) are currently in distress as government announced a strict lockdown to further contain the spread of COVID-19. Given this small retailers all over the country are struggling to meet payroll and are facing tremendous pressure of rent payments.
With a view to alleviate the stress in the system and support our retail partners, we have announced full rent waiver since March 15th 2020, until the government permits reopening of retail operations. Maintenance charges will be reduced as per actual expenses during this period.
Over 200 retailers in our stores across various locations - Palava City, Thane, Pune and South Mumbai will benefit from this waiver.
For residents across our projects
Our hospitality and facilities management teams, across our projects, have been at the forefront to ensure the safety and security of the residents. Temperature check, screening of visitors, sanitisation of commonly accessed areas and premises is been carried out at regular intervals throughout the day. Apart from this, across our sites teams have made arrangements for providing essentials like groceries, milk, vegetables and fruits in the premises. While undertaking these activities our teams are adhering to sanitation, hygiene and social distancing directives as prescribed by the government. The video recognizes the efforts of these unsung heroes.
For migrant workers and daily wage laborers in the city
During these uncertain times, it's the less privileged, the migrant workers and the homeless people who are the most affected. In a bid to help the needy to cope up with the nationwide lockdown, we have initiated free food centers for providing lunch and dinner facilities across the city of Mumbai.
The food distribution is currently being undertaken at Lodha World School, Kalyan Shil Road, Palava; Lodha World School, Majiwada, Thane; Sharda Mandir School, Gamdevi from 12 PM- 3 PM and 7PM – 9:30 PM and at Lodha Dham, Vasai on Mumbai-Ahmedabad Hwy from 11 AM – 6 PM.
Our volunteers are also reaching out to people sheltered under bridges and giving out packed food to the poor and the underprivileged.
While undertaking these activities our volunteers are adhering to sanitation, hygiene and social distancing directives as prescribed by the government.
The right balance between nature and modern infrastructure has inspired people to live in one of
Witnessing the huge demand and the growth prospects, Grade A developers are fortifying their pres
Today, environmental sustainability is key in homebuying and investment decisions. Grade-A develo
Lodha Pay is introduced to provide safe and secure, online payment option to our customers.<
Our homes are safe havens for us and our families. With a significant change in lifestyles and th
A child's environment plays a major role in their development because it includes the surroundi
Studies show that green buildings can save up to 30% of energy and 50% of water. Builders can swi
A home is no longer just a substantial investment – it offers the security of a much deeper, mo
As a matter of fact, water is becoming scarcer as local sources are constantly depleting and disa
Here we take a look at the benefits of investing in real estate, the various sops available for w
The real estate sector in India has been multiplying over the past few years. With increased popu
When moving to a new city for employment, rather than buying a house people preferred renting a h
According to a report by Investment banker Morgan Stanley, millennials are a key force that drive
One of the finest locations in the city of Mumbai - South Central Mumbai is house to some of the
Owning a home is an essential priority for each individual and an aspiration that one desires to
During the last few decades, we have grown as a company, and a nation, at an unprecedented rate.
Over the past couple of years Mumbai has undergone a sea of transformation. With several key infr
The last two years have been filled with life lessons for every individual. This has been a time
The first commercial tower of Lodha Group's Palava, recognized as India's No.1 Liveable City*
Given that real estate is always under scrutiny, it is evident that most people don't understan
RERA is an Act to establish a regulatory body for regulation and promotion of the real estate sec
With meticulous planning, attention to detailing, focus on quality & great craftsmanship we h
A larger, more popular subject usually overshadows a small one. This can be true for people, plac
Shaishav Dharia, Regional CEO, Lodha Group, welcomes Ms. Ashima Bhat , Country Head - Finance, St
As the world of luxury has shifted away from a high price tag and brand/product-centricity and mo
According to a recent report by IBEF, the real estate sector in India is expected to reach a mark
With the new health and safety concerns, homebuyers are now giving more emphasis to the location
Women have been the most significant influencers when making the crucial decision of buying a hom
Lodha Group, India's largest residential estate player, today announced that it will be launchi
With an emerging need for a low density living accompanied by the necessary social distancing mea
All ancient human civilizations were born and flourished around water. How essential water is for
Mint's Pivot or Perish webinar held last month focused on the impact of COVID-19
In the past decade, the concept of luxury has experienced an evolution from something that was sy
Amidst the uncertainty that has engulfed the world, we understand you maybe in two minds about pu
Aside from the obvious financial benefits of home ownership, there are also many social, psycholo
As we start thinking of living in the post-COVID world, there are diverse perspectives on how cit
With the world progressively adapting towards the post Covid-19 lifestyle, consumer needs are als
Since the outbreak of COVID-19 pandemic those staying on rent are left questioning their choice.
Lodha Group: India's No. 1 Real-Estate Developer announces the sale of INR 3000 cro
If you're in the market looking to buy a house, it's likely that you may have been charmed by
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A recent consumer research done by Lodha Developers with active home seekers in Mumbai region dur
At Lodha Group, our passion is to create landmarks that meet global standards. Every one of our d


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With Easter just around the corner you've probably been hearing more than a few stomach's rumble with anticipation as the shops start to stock up on chocolate eggs and other treats. Whilst chocolate is, of course, a deliciousness sent from heaven, some people can be too distracted by its amazing flavour to realise that it actually has a number of amazing powers for your skin and hair!
Treat Yourself With A Chocolate Beauty Treatment
The experts in our Australian salons and spas know this all too well and chocolate has begun to smother their treatment menus from Melbourne to Sydney.
Check on Vaniday Website their salons with chocolate treatment – yes chocolate!
Treat yourself to an indulgent chocolate related treatment this Easter!
Body Benefits Of Chocolate Treatments
With Easter just around the corner you know that there's a lot of chocolate on its way, and we know you are probably getting pretty excited about this like we are. But there could actually be more chocolate in your life than you think… especially when you find out its amazing benefits in wellness treatments! You might have been working really hard to try and stop yourself from consuming any more chocolate but we think it's about time you threw in the towel! Give in to your chocolate loving ways and wave goodbye to your guilt with the amazing chocolate treatments available at Spas across Australia.
- Remove dead layers of skin as well as built up stress with an amazing Chocolate and Coconut Sugar Scrub or maybe a Cabarnet au Chocolat Age Deception Peel.
- Feel your vitality being revived as your highly skilled professional works your skin over with the chocolate infused treatment and breathe in the sweet and sugary aroma leaving you fresh and ready to start putting that easter egg hunt together.
Chocolate? Massage? Heard any words you like yet? Of course you have, chocolate and massage are two of the most appealing words in the english language. Just imagine a situation where you get both of them. Well imagine no longer, as this is now a reality.
Treat yourself to a Chocolate Candle Massage. And why stop there? I mean you wouldn't eat just half a bar of chocolate would you. As soon as you've got the taste for the moisturising, brightening and softening powers of chocolate treatment you'll be hooked for life! Try an amazing Skeyndor Heavenly Chocolate and Vanilla Body Rapture or a Chocolate Algae Wrap to add another level of depth to your chocolate experience.
Have something to add to this story? Please share it in the comments.


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High atmospheric pressure
Higher is the pressure, which reaches elevations in excess of 755 mm Hg. This increase in atmospheric pressure primarily affects people who are prone to mental illness and disease asthma. People with various heart pathologies also feel uncomfortable. This is especially true in a time when the jumps in atmospheric pressure occur rapidly.
People suffering from hypotonia, an increase in atmospheric pressure occurs increased blood pressure. If a person is healthy, in such a situation, in the atmosphere it increases only the upper systolic blood pressure, and if the person is hypertensive, blood pressure he had with the increase in the atmospheric tone.
Low atmospheric pressure
When atmospheric pressure is reduced to the level of 748 mm Hg people with a weather dependent experience severe discomfort. Hypotensive lose power, they have nausea and dizziness. Low atmospheric pressure also affects people with heart rhythm disturbances. Having a tendency to depression and suicide, I feel the aggravation of anxiety and restlessness, sometimes leading to tragic consequences. In this period it is necessary to try to avoid excessive exercise and sports. It is very important that using medications (prescribed by a doctor) and also by hot black tea or (if no contraindications) small portions of alcohol to be able to somehow take control of their health and mood.
At low atmospheric pressure, the lower the partial pressure of oxygen. In arterial blood, markedly reduced the tension of this gas, which stimulates special receptors in the carotid arteries. The impulse is transmitted from them to the brain, resulting in shortness of breath. Due to enhanced pulmonary ventilation, the human body is capable of at altitude (when climbing) fully provided with oxygen.
The overall health of the person under reduced atmospheric pressure reduced by the following two factors: increased activity of the respiratory muscles, requires additional oxygen, and washing out carbon dioxide from the body. A large number of people, at low air pressure see problems with some physiological functions, which leads to oxygen starvation of tissues and is manifested in the appearance of shortness of breath, nausea, nasal bleeding, dyspnea, pain, and changes of smell or taste, as well as arrhythmic heart.


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It's spooky season! Halloween is one of my favourite things to celebrate. It's so much fun and who doesn't love themed goods? Whether you've got little ones to chaperone or an adults only party, these Halloween graveyard cakes are the perfect sweet treat to serve up after hours of trick or treating and dancing the night away.
- 400g plain flour
- 1 tbsp baking powder
- 1 tsp salt
- 170g grape jelly
- 225g granulated sugar
- 4 large eggs at room temperature
- 340g unsalted butter, melted
- 2 tbsps pure vanilla extract
- 230ml milk
- 280g unsalted butter at room temperature
- 1/4 tsp salt
- 780g icing sugar
- 3 tbsps milk
- 10 chocolate biscuits, coarsely crushed
- Preheat the oven to 180°C. Line two 12 cup muffin tins with paper cupcake liners.
- Whisk together the flour, baking powder and salt in a bowl. Warm the grape jelly for approximately 20 to 30 seconds in the microwave until loosened, and whisk until smooth. Set aside.
- Beat together the sugar and eggs in another medium bowl with an electric mixer until light and foamy, about 2 minutes. While beating, gradually pour in the butter and then the vanilla.
- While mixing slowly, add half the dry ingredients and then all of the milk. Follow with the rest of the dry ingredients, taking care not to over mix the batter.
- Remove roughly 500g of the batter and stir in the grape jelly. Evenly fill the liners about two-thirds full, alternating the plain batter and grape batter.
- Bake until a tester inserted in the centre of the cupcakes comes out clean and the tops spring back lightly to the touch, 20 to 22 minutes. Place the pan on a rack to cool for 10 minutes, and then remove the cupcakes to the rack to cool completely, about 1 hour.
- For the frosting, beat the butter and salt in a large bowl until fluffy and combined. Gradually beat in the icing sugar until smooth and fluffy. Beat in the milk one tablespoon at a time until the frosting has a nice spreadable consistency. Add the crushed cookies and continue to beat until any large chunks are crushed to smaller bits and the frosting has a speckled, greyish look.
- To decorate, arrange the cupcakes in 4 rows on a large serving plate or cutting board. Fit a marshmallow between each cupcake, 5 marshmallows per row, to fill in the gaps between the cupcakes. Spread the frosting over the whole rectangle so it looks like one cake. Sprinkle with the cookie crumbs and black decorating sugar.
- To make the tombstones, use the black decorating icing and a small round tip to write 'RIP' or other one-word epitaphs on the top half of the oval sandwich cookies and stick into the cupcakes randomly around the graveyard.
- To make the ghosts, take two-thirds of the marzipan and place between 2 sheets of wax paper or parchment. Roll about 1/8-inch thick and cut into 3 rounds using a 4-inch biscuit cutter. You may need to gather and re-roll the scraps for all 3 rounds. Drape over the wrapped lollipops and stick into the cupcakes around the tombstone. Using the black decorating icing and the same round tip, dot eyes and a mouth on the ghosts.
- To make the pumpkins and leaves, divide the remaining marzipan into 4 small pieces and roll each into a ball. Roll in the orange sugar until coated and place around the graveyard. Use the black icing to pipe a small stem. Fit the tube of green decorating icing with a leaf or ribbon tip to dot bits of green grass poking through the dirt around the graveyard and pumpkins.
- To make a border, use 6 pieces of the liquorice, trimming to fit, to make a border around the cake, leaving the middle of the front side open. Bend the seventh piece into an upside down 'U' and stick into 2 cupcakes in the front to make an arched gateway.
Will you be giving these creepy cakes a go? What's your favourite spooky sweet treat to serve for Halloween?
Jazz is a Disney, tea and pop culture enthusiast with a passion for blogging. Also a proud introvert.


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Soft and sweet 3 Ingredient Baked Pumpkin Donuts – top them with cinnamon-sugar or a simple maple glaze for the ultimate fall treat!
I could eat donuts for breakfast, lunch, and dinner. And midnight snack, which actually happens to be a common thing these days. I love donuts. LOVE THEM. The only person I know who loves donuts more than I do is my sister Tammy who is an absolute donut connoisseur. She seriously knows her donuts. Which is why I'm taking this opportunity to let you know that she gave these homemade baked pumpkin donuts two thumbs up.
The best part about these donuts (seriously it's all good, but if we had to narrow it down…) is that they only have 3 ingredients. I'm so excited about that little fact that I made sure to put it in the title of this post. 3 INGREDIENT BAKED PUMPKIN DONUTS. I was thisclose to naming them The Tastiest and Easiest Pumpkin Donuts You Will Ever Meet In Your Lifetime. But after some careful consideration I realized that's a bit of a mouthful and I'd rather have a mouthful of these donuts to tell you the truth.
They're just so fluffy. And soft. And moist. And purrrrrrdy. You can eat these little nuggets of joy straight-up of course. Just the plain donut. And there's nothing wrong with that – trust me, I've done it. But if you want to jazz them up – and you do, because you've only spent 20 minutes on these things start to finish and now you don't know what to do with all of your time and energy – then you should definitely consider adding that glaze. I threw in a little maple extract because I absolutely adore all things maple + frosting, especially when it comes to fall treats. BUT. If you know you're not a maple fan (that is sad news, but I'll forgive you) then you could sub out the maple for vanilla instead which is still 110% crazy yummalicious.
And even after all of that is said and done and you've only spent 30 minutes now on these donuts (if that) and you find yourself aching to go the extra inch (seriously, it's not even a mile cause it's just so easy) then you should sprinkle a little bit of cinnamon + sugar right on the top of those glazed donuts. When it's all said and done you've spent what, 40 minutes? on these gorgeous donuts. And if you think they are gorgeous to look at, just wait til you taste them. They taste as scrumptious as they look!
Yes. I just said scrumptious. It's that kind of day.
*If you don't have a donut pan, it's about time you got yourself one! I waited soooo long to get one and I have no idea why because they're all of maybe $10?? I used this Wilton 8-cavity Donut Pan, but I'm thinking about getting a 12-cavity pan like this one so that I don't have to do quite as many batches to use up the batter.
What people are saying about these 3 Ingredient Baked Pumpkin Donuts
"I made these last night using gingerbread cake mix, the closest thing I could find to spice cake. I was nervous about the flavor but they turned out PERFECT. And that's without the laze, even. This recipe's a keeper!" – Lizzie
"Easiest recipe ever. My grandchildren helped and they ate every last crumb! Thanks for the tip about putting the glaze in the microwave. It worked perfectly. This recipe is definitely a keeper!" – Mary
3 Ingredient Baked Pumpkin Donuts
- 1 box spice cake mix
- 1 15-ounce can pumpkin puree - (not pumpkin pie filling)
- 1 tablespoon pumpkin pie spice
Cinnamon Spice Coating
- ¼ cup sugar
- 1 tablespoon cinnamon
- 2 ounces cream cheese - softened
- 1 ¼ cups powdered sugar
- ½ teaspoon maple extract - OR 1 teaspoon vanilla extract
- 1 tablespoon milk
- Preheat oven to 350 and grease a donut pan (or more than one if you have it).
- In a large bowl mix together cake mix, pumpkin puree, and pumpkin pie spice. Transfer mixture to a large zip-lock bag, press the excess air out, and seal.
- Snip one bottom corner of the bag off (about 1/2 inch from the corner) and pipe the batter into your prepared donut pan. Bake for 12-14 minutes. Allow to cool for about 5-10 minutes in the pan before transferring to a cooling rack.
- For the cinnamon-sugar coating, simply whisk together cinnamon and sugar, and toss slightly cooled donuts in the mixture to coat.
- For the glaze, cream together cream cheese, powdered sugar, extract, and milk. Warm it in the microwave for a few seconds to make it thin and runny. Dip cooled donuts in glaze. Sprinkle with cinnamon and sugar if desired. Allow to cool completely.
This post contains affiliate links. If you click on the link and end up buying yourself a sweet donut pan, I make a percentage of the sale – woohoo!


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Ralph Tommaso has served his last rigatoni.
On Wednesday night, the owner of La Traviata shut down his 30-year-old Montague Street eatery — leaving only a "Closed" sign with the words, "Lost our lease."
Tommaso could not be reached, but friends said that he caved to exorbitant rents.
"He just couldn't take it anymore," said Robert Fink, owner of the Heights Cleaners next door. "He came by after to say goodbye."
On Thursday, regulars encountered a roll-down gate at the cozy Italian joint between Henry and Clinton streets, a barrier to their $12 chicken cutlet parmigiana or $6 personal-sized pizza.
La Traviata was a mainstay on Montague Street, alongside the Happy Days Diner, Teresa's and the Heights Café — a longtime contender on a strip that's become notorious for high rents and frequent restaurant turnover.
Locals were heartbroken when Armando's, the iconic Heights eatery next door, closed in 2007. The owner, Peter Byros, wanted to retire, so he leased his Italian boite to the Spicy Pickle sandwich chain. But after that shop failed, and Byros brought back his 74-year-old restaurant.
"Restaurant closings are sad, but these things happen here," said Frankie Konidari, a longtime worker at the nearby Grand Canyon Restaurant. "It's just too expensive here."
Tommaso's landlord, Carl Zerbo of Doraldo Holding Corporation, vowed that rent wasn't the problem.
"Ralph just got tired of it," Zerbo said. "I just don't understand it to be honest. There's never been an issue with the lease."
He added, "I've always tried to be fair with him. That's why he's been on the block since the 1980s."
Tommaso was beloved for his large helpings of shrimp scampi, rigatoni a la vodka and thin-crust pizza. His eatery was at one time a father-and-son act that included a Joralemon Street takeout annex, before Ralph Jr. went into the renewable fuel business.
Regulars were puzzled this week to see La Traviata shuttered.
"I've been coming here since they opened," said attorney Vincent Martusciello, a regular who saw no indication of trouble.
"I bring my family, my secretaries, my friends here. Wow, I can't believe they're gone."
Reach Kate Briquelet at [email protected] or by calling her at (718) 260-2511.


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Ashby to Moderate Spotlight on Diversity: Professional Perspectives on Building an ADR Practice
March 07, 2018
Attorney Laura Ashby will moderate a panel discussion titled "Spotlight on Diversity: An Engaging and Informative Panel on ADR" to be held on March 7, 2018 in the Atlanta office of Miller & Martin.
The seminar is co-hosted by Miller & Martin's Women's Network, along with the Atlanta International Arbitration Society Young Practitioners Group and Arbitral Women. The discussion will bring together international, domestic, law firm and corporate perspectives on the changing landscape of alternative dispute resolution ("ADR"). The panel discussion will focus on how younger lawyers can build an ADR practice, as well as current efforts being made in the international arbitration community to involve more diverse attorneys and arbitrators.
2018-03-07 08:30:00 2018-03-07 10:00:00 America/Indiana/Indianapolis Ashby to Moderate Spotlight on Diversity: Professional Perspectives on Building an ADR Practice


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Microtubule-based transport within the axon. The plus-end motor kinesin transports cargoes anterogradely while those that need to be brought back to the cell body are transported by the minus-end motor dynein and some kinesins.
Disruption of transport within narrow-caliber, long axons could lead to stalling of vesicles and formation of cytoplasmic inclusions within axonal processes, which may ultimately lead to neuronal death and dysfunction. Thus, accumulation of organelles within axonal processes may instigate an early neurodegenerative disease pathway.
Customize your JAMA Network experience by selecting one or more topics from the list below.
Gunawardena S, Goldstein LSB. Polyglutamine Diseases and Transport Problems: Deadly Traffic Jams on Neuronal Highways. Arch Neurol. 2005;62(1):46–51. doi:10.1001/archneur.62.1.46
© 2023
The expansion of CAG repeats encoding glutamine (polyQ) causes, to date, 9 late-onset progressive neurodegenerative disorders, including Huntington disease, spinobulbar muscular atrophy, dentatorubral-pallidoluysian atrophy, and spinocerebellar ataxias 1, 2, 3, 6, 7, and 17. Although many studies using both knockout and transgenic mouse models suggest that a toxic gain of function is central to neuronal dysfunction, the exact mechanisms of neurotoxic effects remain elusive. Protein aggregations within neurons seem to be a common manifestation in almost all polyQ diseases, and such accumulations are perhaps major triggers of cellular stress and neuronal death. Recent data lead to the tantalizing proposal that disruption of axonal transport pathways within long, narrow-caliber axons could lead to protein accumulations that can elicit neuronal death, ultimately causing a neuronal dysfunction pathway observed in polyQ expanded diseases. Perhaps perturbations in transport pathways are an early event involved in instigating polyQ disease pathology.
Our nervous system can be thought of as requiring a transport system composed of highways that transport essential cargoes from a central station, cell bodies in the spinal cord or brain, to places of need, nerve terminals or synapses, very much like a busy freeway system. Most materials within axons or synapses are synthesized within the neuronal cell body and are moved along lengthy axons to sites of function. Molecular motors, such as kinesin and dynein, are proteins that power cargo transport and use adenosine triphosphate hydrolysis to move vital cargoes on microtubule tracks (Figure 1). Within axons, organelles, vesicles, cytoskeletal proteins, signaling molecules, and other supplies from the cell body are transported by kinesin motors in the anterograde direction to nerve terminals and synapses, while signaling molecules and other components that need to be returned to the cell body from synapses are transported in the retrograde direction by dynein and some kinesin motors. Since transport of cargoes is required for cell viability, it is conceivable that disruption in this long distance transport system can lead to disease pathology observed in many neurodegenerative diseases, including polyglutamine (polyQ) diseases.
The importance of the axonal transport system in disease states has been recently highlighted by several intriguing studies. These studies not only suggest that strangulation of the axon may led to disease pathology but also implicate components of the axonal transport machinery as targets for the development of human disease. Mutations in KIF1Bβ result in Charcot-Marie-Tooth disease type 2A, which is characterized by progressive dysfunction of peripheral neurons, possibly owing to the reduced transport of synaptic vesicle precursors.1 A missense mutation in the neuronal kinesin heavy chain gene KIF5A results in hereditary spastic paraplegia, a condition that arises owing to axonal degeneration of motor and sensory neurons at the distal ends of the longest axons of the central nervous system.2 In a dynamitin (a component of the dynactin complex that interacts with dynein) overexpressing mouse model,3 excess dynamitin disassembles dynactin and inhibits retrograde transport, suggesting that impediment of axonal transport is sufficient to cause motor neuron degeneration observed in amyotrophic lateral sclerosis. While mice with transgenic amyotrophic lateral sclerosis showed abnormalities in microtubule-based transport, with decreased rates of slow axonal transport and degeneration of motor neurons,4 the dynamitin transgenic mice demonstrate a late-onset progressive motor neuron degenerative disease.3 A mutation in the human dynactin gene DCTN1 causes human motor neuron disease,5 and missense mutations in cytoplasmic dynein heavy chain (Dnchc1) cause selective impairment of axonal retrograde transport, cell death, Lewy body–like inclusions, and progressive motor neuron degeneration.6 Together, these studies argue that axonal transport failure can be a causative feature in neurodegenerative disease, strengthening the proposal that disruption of axonal transport is an important determinant in the initiation and perhaps the progression of pathogenesis.
Axonal transport problems have also been implicated in Alzheimer disease (AD). Recent work from our laboratory demonstrates that the amyloid precursor protein (APP) can function as a kinesin-I receptor.7,8 In Drosophila overexpression of wildtype human APP or familial mutations responsible for AD (Swedish and London) cause axonal vesicle accumulations, which contain APP and trigger neuronal cell death.8 Secretases (β-secretase and presenilin [PS]) that are responsible for the generation of pathogenic amyloid-β (Aβ) appear to be present in APP vesicles.9 Perhaps axonal blockages containing APP vesicles are sites of Aβ production, and processing of APP within these sites leads to the dissociation of kinesin from APP vesicles leading to the failure of transport within narrow axons, thus triggering the induction of neuronal dysfunction or death.
Yet another link between AD and axonal transport problems comes from the observation that PS, a component of the γ-secretase complex, interacts with GSK3β.10 An enhancement in GSK3β activation and a deficiency in kinesin-1–mediated transport were observed in PS mutations that cause familial AD (FAD).11 Intriguingly, GSK3β phosphorylates kinesin light chains leading to the dissociation of kinesin from membranes.12 Perhaps the disassociation of kinesin from APP-PS–containing vesicles results in the failure of transport in FAD-PS mutants. Together, these observations suggest that the axonal transport pathway may be central to the pathogenesis observed in AD.
Disruptions in transport pathways could also be involved in the pathogenesis of Huntington disease (HD) and other polyQ expansion diseases. Since protein aggregates are a common feature in all polyQ diseases, it is conceivable that failure in the transport system may also result in polyQ pathogenesis. Herein we briefly highlight polyQ disease pathology and discuss several recent advances relating this pathology to possible transport problems.
Polyglutamine repeat diseases are a class of hereditary neurodegenerative diseases caused by the expansion of CAG triplet repeats encoding a polyglutamine tract in the normal protein (Table). These disorders are progressive, dominantly inherited (except for spinobulbar muscular atrophy), typically begin in midlife, and result in severe neuronal dysfunction and neuronal cell death. The expanded trinucleotide repeats are unstable, with increased repeat length correlating with worsening of the disease phenotype. The polyQ expansion is believed to confer a toxic gain of function, perhaps causing an increased propensity for the mutant protein to misfold and aggregate. Although all 9 polyQ diseases are genetically distinct and can be characterized by their specific lesion distributions in the nervous system, recent studies indicate that except for spinocerebellar ataxia (SCA) types 2 and 6, the formation of intranuclear inclusions within neurons is a common hallmark of all 9 diseases. Nuclear inclusions have been found in neuronal populations susceptible to the disease process, and this has lead to the widespread belief that intranuclear aggregations are central to polyQ pathogenesis.
Clinically, polyQ disorders share several common features, including slow progression and late (adult) onset. They also exhibit anticipation, becoming earlier and/or more severe in succeeding generations, which is correlated with an intergenerational increase in repeat length. Each of the polyQ disorders affect specific but overlapping regions of the brain. The clinical pathologic features of spinobulbar muscular atrophy is relatively distinct, whereas that of dentatorubral-pallidoluysian atrophy overlaps HD, and SCAs (reviewed in Evert et al13). Involuntary movements, intellectual impairment, and emotional disturbances clinically characterize HD, while spinobulbar muscular atrophy is a rare progressive neuromuscular disorder characterized by proximal weakness, atrophy, and fasciculations. Dentatorubral-pallidoluysian atrophy is characterized by progressive dementia, myoclonic epilepsy, cerebellar ataxia, and choreoathetotic movements. All SCAs exhibit variable degrees of cerebellar and brainstem degeneration accompanied by progressive cerebellar ataxia associated neurological signs including ophthalmoplegia, dementia, and extrapyramidal signs.
At the molecular level, polyQ disease proteins are expressed ubiquitously throughout the brain and other tissues, although the normal function of most of these proteins remains unknown (Table). Exceptions are the androgen receptor in spinobulbar muscular atrophy, the P/Q-type calcium channel subunit in SCA6, and, based on recent work the huntingtin protein. Except for SCA3, the polyQ tract is located toward the N-terminal region of the protein in all polyQ diseases. Apart from the polyQ tract, the polyQ proteins do not share any other common features. In the case of SCA3 and HD, cleavage of the mutant protein is thought to promote aggregation.
Although little is known about the mechanism by which polyQ expansion leads to pathogenesis, one proposal is that misfolding of the mutant protein triggers a cascade of events, which ultimately leads to disease pathology (reviewed in Evert et al13). The misfolded protein may undergo proteolytic cleavage, interact with other proteins, self-aggregate, and these aggregates may later translocate into the nucleus. Although the propensity of polyQ proteins to aggregate is a common feature observed in all 9 polyQ expansion diseases, it remains unclear whether aggregates, which contain not only mutant protein but components of the ubiquitin-proteosome pathway, chaperones, transcriptional regulators, and other polyQ-containing proteins, are the cause of pathogenesis or the end result of a cascade of events. Indeed, Wanker14 postulates that aggregates themselves are neurotoxic even though the distribution of aggregates within the central nervous system does not completely match areas of neuronal loss.15
Whatever the cause, most proposals for disease mechanism include the hypothesis that aggregates alone are a precondition of neurotoxic effects, and several models propose that dysfunction originates from aggregate formation (reviewed in Tarlac and Storey16): (1) Sequestration of cellular factors away from their usual locations into aggregates are proposed to compromise their function and cause toxic effects; (2) recruitment of transcription factors into aggregates are proposed to attenuate transcription factor function; and (3) accumulation of molecular chaperones and proteosomes into aggregates are proposed to limit their availability in the cell, leading to diminished clearance and harmful accumulation of misfolded or damaged proteins, eventually activating cellular stress response pathways and inducing apoptosis.
In contrast, however, many recent studies propose that neuronal dysfunction occurs before aggregate formation. Prior to the detection of aggregates, neuronal and behavioral problems were detected in knock-in HD mice with 94 CAG repeats,17 in SCA1 mice with 154 CAG repeats,18 and in SCA7 mice with 266 CAG repeats.19 Indeed, another model suggests that aggregation of polyQ proteins may initially function as beneficial "sinks" that activate degradation pathways, which may later become defective owing to overactivation, ultimately resulting in neuronal dysfunction.20 Since ubiquitin and components of the proteosome were observed to colocalize with aggregates, further aggregation of polyQ proteins might block the degradation pathway.
An important point of controversy is whether neuronal toxic effects observed in polyQ diseases results from nuclear or cytoplasmic events. The most common type of aggregates observed in polyQ disease are intranuclear, but these may occur later in disease progression owing to problems or failures in other pathways. Indeed, neuropil aggregates were observed with expanded polyQ repeats in the context of the androgen receptor21 in transgenic HD mice and in HD-affected patient brains before the onset of clinical problems.22,23 Similarly, Klement et al24 demonstrate that while nuclear localization of ataxin-1 is necessary, nuclear aggregation of ataxin-1 is not required for initial pathogenesis in transgenic SCA1 mice. Consistent with these findings are recent results demonstrating that both cytoplasmic and nuclear accumulation pathways can independently lead to neuronal dysfunction25 and that cytoplasmic accumulations precede nuclear inclusions.26 Thus, cytoplasmic accumulations may be the primary events in toxic effects. However, it is still unknown if protein cleavage plays a role, and if aberrant cleavage of N-terminal fragments containing pathogenic polyQ repeats are the cause of cytoplasmic inclusion formation and disease pathology. Perhaps the cytoplasmic accumulations observed within axons are sites of N-terminal cleavage, and these pathogenic N-terminal fragments then promote nuclear entry and activate transcriptional processes, which may lead to nuclear-mediated toxic events.22,25,27
Viewed broadly, an intriguing feature of polyQ disease is that while disease-causing genes are widely expressed (Table), only neurons are affected. These observations raise the question of whether the specificity observed is due to the nature of the neuron, with its long narrow axonal and dendritic processes. Essential components must be transported over great distances in axons and dendrites along microtubule tracks for cell viability. Perhaps defects in this transportation system have long-term effects on polyQ disease pathology.
Although genes encoding motor proteins may be key players in human diseases when mutated, it is possible that proteins that regulate or interact with motor proteins may also cause disease when mutated. Alternatively, abnormal interactions of proteins not normally functioning in transport could cause transport problems subsequently leading to neuronal defects. Indeed, the widespread occurrence of axonal (or dendritic) inclusions observed in polyQ diseases raises the possibility that perturbations of transport pathways are an early susceptibility factor in disease pathology. In fact, new work leads to the proposal that stalling of vesicles within narrow caliber axons triggers aggregate formation within axons, which could then initiate a cascade of events, resulting in neuronal death and dysfunction (Figure 2).25 There are 2 complementary aspects to this proposal: (1) disease-causing proteins may have normal functions in the axonal transport system and may cause axonal blockages when altered; and (2) "sticky" diseased proteins may physically block transport within narrow axonal processes, and also titrate normal proteins, instigating pathways that lead to subsequent neuronal problems.
Many observations support these proposals for HD. In 1997, Block-Galarza et al28 showed that huntingtin, the protein that causes HD, was transported both anterogradely and retrogradely in rat sciatic nerve axons. Immunolocalization studies in human and rat brains revealed cytoplasmic huntingtin within neurons, and biochemical analyses indicated that huntingtin was enriched in compartments containing vesicle-associated proteins.29,30 Recently our laboratory found that normal Drosophila huntingtin functions in the axonal transport pathway, perhaps to transport a subclass of vesicles.25 Although how huntingtin associates with the axonal transport machinery is still unclear, it can be proposed that huntingtin may associate with motor proteins via HAP1, a protein that has been shown to interact with both huntingtin and the p150 subunit of dynactin,27 thereby enabling retrograde transport and perhaps anterograde transport.31 HAP1 itself is transported both anterogradely and retrogradely and also associates with vesicles and with microtubules.28,32,33 Intriguingly, mutations in the Drosophila HAP1-like protein, Milton, causes axonal transport defects and may function in the transport of mitochondria to synapses by binding to kinesin.34 Thus huntingtin and HAP1 may have vital roles in axonal transport and perhaps with dynactin they have a role in establishing bidirectional transport.
Pathologic evidence for axonal transport problems in HD comes from observations in transgenic HD mouse models and human patient brains. Several groups have demonstrated that dystrophic striatal and corticostriatal neurites in HD exhibit characteristics of blocked axons, namely, accumulations of vesicles and organelles in swollen axonal projections and termini in association with huntingtin aggregates.30,35 Huntingtin accumulations have been found in axons of striatal projection neurons in R6/2 and knockin mouse models of HD and in human patient brains.23 These striatal axonal inclusions are better correlated with striatal neuronal loss than the presence of nuclear inclusions. Intriguingly, the axonal pathology observed in striatal neurons is virtually identical to the phenotype of motor protein mutants in Drosophila and polyQ-induced axonal blockages found in Drosophila models of polyQ disease.25,36
Although little is known about how these phenotypes arise and whether these observations are an early indication of neurodegeneration or the initial step in a cascade of events that cause dysfunction, these findings together with the evidence for cytosolic localization of full-length huntingtin protein and its association with cytoskeletal and vesicular structures are compelling arguments for a role of axonal transport in the pathology of HD. Since mutant huntingtin was shown to interfere with its anterograde transport, contributing to the depletion of brain-derived neurotrophic factor in the striatum,37 perhaps normal huntingtin is required for efficient vesicle trafficking of cortical brain-derived neurotrophic factor. Indeed, a recent study supports this proposal.38
A similar mechanism can be proposed for other polyQ diseases. Expression of expanded polyQ repeats in the context of the androgen receptor also causes neuropil aggregates and alters the distribution of kinesin.21 Consistent with this, recent data from Szebenyi et al39 demonstrate a polyQ length-dependent inhibition of anterograde and retrograde transport in isolated squid axoplasm by truncated versions of huntingtin or the androgen receptor. In SCA6, axonal accumulations are observed that appear to contain accumulations of neurofilaments and other materials that fail to be transported.40 In addition, expression of different pathogenic polyQ proteins within Drosophila neurons cause axonal blockages, which increase with reductions in motor proteins and reduce the amount of motor proteins available for normal transport.25 These observations suggest that accumulations of disease proteins, perhaps those that are sticky, can physically block transport pathways and titrate motors proteins away from their normal functions within narrow- caliber axons or dendritic processes. Consistent with this idea, it was recently shown that cytoplasmic huntingtin aggregates trap or titrate polyQ proteins, which may further block transport pathways.41 Thus, the 2 pathogenic pathways suggested by the transport hypothesis (described earlier) may not be mutually exclusive.
Although transport problems cannot account for all aspects of polyQ disease pathology, they provide a plausible explanation for how failures in the transport system could result in neuronal loss. Future experiments should focus on investigating axonal transport problems in other polyQ diseases for which excellent animal models are available and for which human tissues are readily accessible. Since different motor proteins move a variety of cargoes, including membrane organelles, protein complexes, complexes of nucleic acids, signaling molecules, neuroprotective and repair molecules and cytoskeletal complexes along microtubule tracks, the susceptibility of different neurons to different polyQ disease may result owing to the specialized function of the normal protein within those neurons. Thus, rigorous investigations are needed to elucidate the normal functions of proteins involved in polyQ diseases, in particular to determine if these are involved in the axonal transport pathway.
Although it is still not understood how polyQ disease pathology is caused, several groups have focused on identifying chemical agents that modulate cell toxicity or aggregation in a variety of polyQ disease models including yeast, Caenorhabditis elegans, Drosophila, and mouse (reviewed in Bates and Hockly42). Current potential therapeutic interventions targeting specific molecular events include minocycline (a caspase 1 inhibitor), cystamine (an inhibitor of tissue transglutaminase), Congo red (an inhibitor of polyQ aggregation), and suberoylanilide hydroxamic acid (a hydroxamic acid inhibitor) (reviewed in Bates and Hockly42). It is still unknown if these compounds act on the target for which they were selected. While it is important to distinguish if transport failures are an early secondary problem as opposed to being the true initiating cause of polyQ disease, pharmacological interventions directed toward the transport process may be valuable in the development of therapies. An important first step is to test if any of the above compounds prevent axonal transport problems in the in vivo Drosophila model system, which exhibits specific axonal transport phenotypes within polyQ expressing neurons.25 Ultimately, it is critical to develop axonal transport assays in living patients.
Correspondence: Lawrence S. B. Goldstein, PhD, Howard Hughes Medical Institute, Cellular and Molecular Medicine West, Room 336, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093-0683 (firstname.lastname@example.com).
Accepted for Publication: August 5, 2004.
Author Contributions:Study concept and design: Gunawardena and Goldstein. Analysis and interpretation of data: Gunawardena and Goldstein. Drafting of the manuscript: Gunawardena. Critical revision of the manuscript for important intellectual content: Gunawardena and Goldstein. Obtained funding: Goldstein. Administrative, technical, and material support: Gunawardena. Study supervision: Goldstein.
Funding/Support: This study was supported by a fellowship from the Wills Foundation, Houston, Tex, and by a senior postdoctoral fellowship from the Ellison Medical Foundation/American Federation for Aging Research (AFAR), New York, NY (Dr Gunawardena). Dr Goldstein is an investigator of the Howard Hughes Medical Institute, Chevy Chase, Md.
Acknowledgments: We apologize to those authors whose work was not cited owing to space limitations.


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An MIT scientist has developed a quick and dirty way to harness solar power using "anything green, even grass clippings." So basically, solar panels made out of yard waste.
This technology is way, way, way, way below the efficiency of commercial solar panels: It converts 0.1 percent of solar energy into power. Commercial solar panels clock in around 10 to 15 percent; the most advanced lab models are pushing even higher.
But the simplicity of the design makes up for that shortcoming. In theory, anyone could start harnessing solar energy by taking a bag of grass clippings, using an inexpensive membrane to filter out PS-I molecules (responsible for the magic of photosynthesis), and mixing the molecules with a bag of chemicals to stabilize them. Paint the mixture on a roof, and — voila! — solar power.
Bonus biomimicry: Not only does this design riff off photosynthesis, it took inspiration from pine forests to increase its efficiency from "so minuscule it doesn't matter" to "just really, really small." Andreas Mershin, the scientist behind this project, designed a "tiny forest of zinc oxide nanowires" to hold to PS-I molecules, so that as sunlight filters down, the molecules can continue to capture it — just like in a forest.


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This weeks tweets feature @DIBLiv, @LpoolBIDcompany,@hpc_alex, @JoeCampbell1994, @EricWrightGroup, @haveigotnews, @mrdanwalker and @makeyoucontent.
⚡ "LIMITLESS LUNCH in association with the @LpoolBIDcompany"https://t.co/U1rRQx6DX4
— Downtown Liverpool in Business (@DIBLiv) October 1, 2018
Lovely to see so many faces at our Limitless Lunch joint event with @DIBLiv pic.twitter.com/7wWzo4G6aR
— Liverpool BID Co. (@LpoolBIDcompany) September 27, 2018
Brilliant range of speakers today at @DowntownBusines's Limitless Conference. Very inspiring to hear everyones success stories! pic.twitter.com/MAPV1l8lKd
— Alex Neary (@HPC_Alex) September 27, 2018
Really enjoyed today's @DowntownBusines event at @hiltonliverpool great talks from @ben_hatton1 @RachelClacher and @CMcVoy chaired by @DowntownFrank 👏🏻@LpoolBIDcompany pic.twitter.com/83YerpDA28
— Joe Campbell (@JoeCampbell1994) September 27, 2018
We are delighted to announce that CITB have appointed Diane Bourne, Managing Director of Eric Wright Civil Engineering, onto the Nations Council for England. https://t.co/R8qeeqxsOC #CivilEngineering #CITB pic.twitter.com/mr8b4fIpnU
— Eric Wright (@EricWrightGroup) October 1, 2018
Lineup for Theresa May's 'Festival of Brexit' announced: pic.twitter.com/UGkvXoWpMY
— Have I Got News For You (@haveigotnews) October 1, 2018
Picked up my 1st new suit in a long time today. Thanks to Sam & the guys at @SigBespoke for their hard work. Just need to avoid spilling any yoghurt on this beauty pic.twitter.com/Sile9TZaQx
— Dan Walker (@mrdanwalker) October 3, 2018
We're proud of our Manchester roots and we're always looking to grow our network! That's why we're thrilled to have joined @DIBManc. Are you a member? Say hello if so! pic.twitter.com/jkgYlRjInO
— Making You Content (@makeyoucontent) October 3, 2018


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Tuesday, January 29, 2013
No Concept of Personal Space
14 comments:
Crystal, he is adorable ... AND in your face! :) He is so well done!!! Big HUZZAHS to you!!!ReplyDelete
A big huzzah! The Pom is soooooo cute.ReplyDelete
Crystal so cute! I love your work as always! I hope you will come and visit!ReplyDelete
2013 Artists Series
Not a fan of small dogs, but this is really well done.ReplyDelete
Love this doggie! My small Chihuahuas are very much the same. Great painting! I am also doing the 30 in 30 and learning a bunch about becoming loose and free. Thanks!ReplyDelete
Oh I know that look! Brilliant painting :)ReplyDelete
"pretty cute" is an understatement Crystal, it's the cutest thing ever, oh·those·eyes!!ReplyDelete
- AnonymousJanuary 29, 2013 at 1:21 PM
Great work! Looks so much like my Chihuahua....I am a small dog lover. I look forward to your assessment tomorrow....ReplyDelete
Beautiful work! You nailed it.ReplyDelete
He is so cute! What a great angle!ReplyDelete
This is adorable!! He is the cutest!! Oh those eyes... *sigh*... How do you do that???ReplyDelete
Codi used to think she was a lap dog - even though she was as tall as a Labrador! :0)
This is SO beautiful, Crystal. Many years back I had a dachshund that was always "close" to my face and I really miss her...Love the cropped version..ReplyDelete
Well done Crystal-you're right about that foreshortening issue when doing a dogs face-very trickyReplyDelete
All of your work is wonderful but this little portrait is so intense it stopped me in my tracks!ReplyDelete
Thanks so much for taking the time to leave a comment they really do mean so much to me! Because not all bloggers have their email enabled so I can reply directly through email I will try to reply here in the comments. If I don't please forgive me, life must have been hectic that day! :)) Huzzah!!


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In honor of Psych, one of my top-five favorite basic cable comedy shows about a fake psychic detective agency, I've decided to start asking myself, "what would Shawn Spencer say?" or WWSSS for short (bracelets and other paraphernalia coming soon).
For example today, when a female co-worker told me "Wow, you look very un-slovenly today," SS would have S'd one of the following:
"Yes, but don't worry, tomorrow I'll return to my usual look, which I call 'homeless man riding on the No. 9 train to Slumsville with my trusty one-eyed, three-legged dog named 'Chipper' who only tolerates my oppressive stench because I let him eat out of my economy-size can of baked beans.'"
"Why, thank you. I recently tripped over something and discovered it was called an I-ron, and while it has extremely limited potential as a potato chip-maker, it turns out it can actually take wrinkles out of clothes."
"Wow, with friends to boost your ego like that, who needs parents?"
"Aww, you're too kind. When you say it like that, it almost doesn't sound like an insult."
"Hey, now. Don't be a carbon copy of Rachel McAdams' character in Mean Girls."
"Thank you. Can you keep a secret? They're coming for me today. The Children of the Corn. I've been applying and begging them to let me join for years, and this could finally be my big break."
"Well, I figured I should look my best for the back-handed compliment award ceremony we're having later today."
I didn't say any of these things. But I could have. Well, except for the one about the potato-chip maker. That's kind of a tongue-twister.
Anyway, you're on notice, fake compliment givers. And just in case anyone is still reading, I'll leave you with my favorite Spencer-ism of all time (so far):
Gus: How'd it go?
Shawn: Crashed and burned. Then somehow crashed again, in Chile, only to be eaten by my soccer teammates.


text:
SafeMoon Blockchain: Activity Highlight | SafeMoon Gaming: Tomorrow's Event [FIFA] | Food for Thought | Reminders
SafeMoon Blockchain Activity Highlight
#SAFEMOONFAMILY, we want to give a shout-out to our awesome Blockchain Development Team! They've been working hard behind the scenes, and we want to celebrate their fantastic progress by sharing their latest update with you. 🙌 Blockchain Development Updates: ☑ Chain SOS Wallet Wrapper testing complete ☑ Chain Tokenomics Model in progress ☑ Chain SOS P2P Wrapper data flow exploration & feasibility analysis in progress ☑ Chain AWS development environment setup in progress *These updates are a mix of recent activities. No timelines are stated or implied. #SAFEMOON #SAFEMOONBLOCKCHAIN #WEB3MOVEMENTFOREVERYONE"
SafeMoon Gaming
Join the SafeMoon Gaming Discord to participate in upcoming events, chat with fellow gamers, and even submit suggestions for future gaming events! Regardless of whether you're a novice or a seasoned gamer, we extend a warm welcome to all levels of gaming experience. ❤
🗓No events are scheduled for today.
🗓Tomorrow's Event: FIFA
Lace-up your virtual boots, and let's hit the pitch for some FIFA action tomorrow at 3 pm MDT | 5 pm EST | 9 pm GMT.
💭 Food For Thought
"Ideas are like dreams; they will disappear unless we record them. Write a book, start a podcast, build a brand—anything that makes your ideas real."
- Simon Sinek
"Each seed grows at a pace of its own. This does not mean it won't bloom."
- Unknown
"Strong minds discuss ideas, average minds discuss events, weak minds discuss people."
- Socrates
SafeMoon Cross-Chain Supply
The SafeMoon Education Team prepared an article to help in understanding the SafeMoon cross-chain supply.
"We recently introduced two new pairings - one on Ethereum (ETH) and the other on Polygon (MATIC). To address the potential confusion within the community regarding the token supply, we want to explain the rationale behind these pairings and how they affect SafeMoon's overall supply..." Click to read more.
SafeMoon Special - Hello Again
SafeMoon Pulse Monthly Recap
Each month, the SafeMoon Pulse offers a comprehensive SafeMoon overview of the previous month, including any updates or changes you might have missed. Let's recap the month of February! The video is below, or if you prefer reading, you can access the Pulse article here.
SafeMoon Wallet: How to Sell Crypto Guide
SafeMoon Orbital Shield
SafeMoon released a technical explanation of their patent-pending security product, SafeMoon Orbital Shield.
Need a slightly more simplified explanation?
PoA Article
What is PoA, and what are its advantages?
Learn more by clicking the image below.
Recent Captain's Logs
SafeMoon Exchange
SafeMoon CEO John Karony talks about SafeMoon's Centralized Exchange
(CEX) progress in the Captain's Log video below.
SafeMoon Blockchain
CEO John Karony gave a quick update on the SafeMoon blockchain explaining a bit about the chosen consensus mechanism and release expectations.
Token Monetization Innovation (TMI)
SafeMoon has released a new patent pending feature designed to improve the user experience on its DEX (Decentralized Exchange - SafeMoon SWaP), labeling the feature TMI (Token Monetization Innovation).
TMI aims to improve transparency and transaction predictability by charging the exchange fees upfront in the native token and using smart contracts to ensure transparency in token liquidity pairings. It also aims to expand the availability of web3 and enable additional community partnerships with meaningful projects.
TMI SafeMoon Newsletter Captain's Log.
pSFM Migration
Attention pSafeMoon holders ONLY.
The pSFM Migration Campaign is now LIVE!
Only use the official dApp link on the SafeMoon Website.⚠
Have the tokens you want to use for migration in your wallet.
Don't transfer after the cutoff date/time
Have a small amount of ETH for gas fees
Tokens acquired in wallets after the cutoff date/time won't be eligible
The pSafeMoon process will remain live for a minimum of six months.
Migrate your pSafeMoon tokens to SafeMoon V2 tokens
The pSafeMoon Guide now includes an updates section so you can be aware of any issues relating to pSafeMoon. In addition, you'll find some FAQs to keep you all up to date.
Tokenomics Supervisor
SafeMoon announced that with the recent SafeMoon SWaP updates came a new patent pending feature that solves the existing Defi inconsistent fee paradigm for tokens on multiple Decentralized Exchanges.
Press Release: [Businesswire]
They partnered with "Blockchain and AI expert Dr. Adel Elmessiry to help solve the inconsistency. Labeling the invention "Tokenomic Supervisor," they explain that it operates in 2 steps:
Token Registration
Token SWaP
To learn more, view the full article here.
Security Questions (Best Practice)
🎓You might have seen that SafeMoon Orbital Shield requires users to answer 2 security questions.
⚠We highly encourage reading our Best Practice article to learn about a safer method for answering these security questions!
Slippage and Gas Articles
You may have heard of slippage and gas related to the transactions you make when trading your digital assets on the blockchain, but do you know what they are, where they come into play during a transaction, or even why they exist?
SafeMoon Education Manager Cats published two new educational articles for those interested in understanding more.
⬇Click on the image of the subject you'd like to learn about first.⬇
↙ Learn about Slippage (Left) and Gas (Right) ↘
Understanding SafeMoon Transactions Article
🎓Want to understand more about what happens when a SafeMoon SWaP transaction takes place? Here's an article that can help you understand the process a bit further.
Check it out by clicking the image below. 👇👇👇
SafeMoon Career Opportunities
"Are you someone who imagines new realities & wants to collaborate with others to bring that new reality into being, for the good of everyone? Or maybe you know someone who might be a good fit?"
SafeMoon Gaming
Click below to join the SafeMoon Official Gaming Discord:
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Please be advised this is meant to be used for informational and educational purposes only. All information should be used as such and not be treated as financial advice. Before making any financial decisions, it is important to complete your own due diligence. Thank you.


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http://alanpaul.net/wp-content/uploads/2014/03/alan-imus-300x158.jpg 0 0 AlanPaul http://alanpaul.net/wp-content/uploads/2014/03/alan-imus-300x158.jpg AlanPaul2006-10-09 15:48:002006-10-09 15:48:00Quickie update
Back from a great great trip.
Folks left this morning and we are battling vacation hangovers to go along with mising them and wicked colds or worse (all of us except Eli, the Everready bunny of kids).
I took hundreds of pictures in Lijiang and Shangri La (which is basically Tibet) and will get more up soon. But first I have to finish writing a column and gettingmy feet back on the ground.


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Canadian journalist Donna Laframboise. Former National Post & Toronto Star columnist, past vice president of the Canadian Civil Liberties Association.
I'm currently house-sitting for friends in a small community while working on my book. Yesterday this entire town shut down following a hydro outage that began at seven in the morning and extended past midnight. High winds felled numerous trees in the area, which brought down power lines in multiple locations and blocked roadways. These photos were taken by a friend. The shed is in his backyard.
I spent the day expecting power to be restored at any moment, but 12 hours later it was time to dust off lanterns and locate extra blankets. Although my hot water heater no longer functioned, I'm fortunate that the kitchen stove is powered by natural gas and that the burners can be lit manually.
In the short term, my biggest concern was recharging my phone. Internet access had crashed a few minutes prior to the hydro, taking the VOIP-based telephone service with it. My iPhone was therefore my last remaining link to the larger world. As the sans electricity hours dragged on, I watched the battery indicator on the screen diminish and began contemplating the three diesel-powered generators within view (two connected to businesses and the other to a private home) with new interest.
Eventually, I found myself sitting in the driver's seat of my friends' car. It being a standard transmission, which I've never had occasion to learn how to drive, I've not paid that car the least attention, despite having spent many weeks at a time here over the past 18 months. The size of this community means that walking and cycling is more than sufficient. But there I was, inserting a key into the ignition, my phone charger plugged directly into a 115v socket on the dashboard, thanking the fates for small miracles.
A stroll down main street revealed that nearly everything was closed. The post office. The public library. The government licensing bureau. Neither medication nor flashlight batteries could be acquired from the locked and darkened pharmacy. The foot-long hotdog stand was shuttered. Even Tim Horton's – a Canadian coffee and donut icon affectionately known as Tim's – had thrown in the towel. A convenience store was open but if, like me, you'd neglected to grab cash from a banking machine the previous evening, even milk was unattainable.
At dinnertime, I used the stovetop to fix myself the day's first hot meal, observing that the entire affair was a great deal more bother, consumed far more energy, and dirtied twice as many dishes than usual. (On a normal day, I am Mistress of the Microwave.) Washing all those dishes will now also consume above-average amounts of hot water and detergent.
Temperature became a concern yesterday, from two directions. Indoors, the thermostat dropped to 17 C (63 F), before I began in earnest to explore how the supplementary baseboard heaters could be adjusted upward. On the other end of the spectrum, after 12 hours plus, the contents of one's refrigerator begin to be a source of trepidation. Would those lovely, brown, hard-boiled eggs still be safe to eat?
As darkness approached the tone of concern in the telephone voices of my husband and aunt grew sharper. Safety is always a bit of an issue for a woman on her own. When communities are plunged into darkness, and when there's an awareness that emergency personnel have already been stretched to the limit, we're reminded that the security of our person is largely dependent on other people's self-restraint.
While we're on the subject of safety, Brenda Hazlewood, a
friend who lives nearby, commented on Facebook this morning:
What a frightening drive back into town last night – trees uprooted, roofs blown off – roads blocked, forcing me to turn around and find a new route several times…When I went to bed last night, the only sound (besides wind) was generators humming all around the neighbourhood. I worried about basement flooding without the sump pump running…
She then thanked a third party for the loan of a radio that had kept her "in touch with the world."
At no point yesterday did I become distressed. In my bones I'm a practical gal who learned early on that few things should be taken for granted. When I was a child in the 1960s my paternal grandparents had not yet acquired running water or a flush toilet. One of my earliest memories involves walking down the hill behind my grandmother's house, watching her drop a bucket into the well, hearing it splash, observing her exertion as she pulled it up with a rope, and watching that hard-earned water slosh over the edge of the bucket as we made our way back up the hill.
No one needs to tell me, therefore, that it's possible to live without modern conveniences. But I know how tough my grandparents' lives were.
Newspaper editorial writers (see here) may think it would be good for the planet if we used less fuel and got used to paying higher prices for energy (which means, of course, paying higher prices for anything manufactured or transported). But even though the average person may never have considered the matter in a systematic way, and even though they might not be able to articulate it, folks know what that means.
An unstable energy supply, or an energy supply that is difficult for ordinary people to afford, translates into a lower level of food safety and a lower level of public safety. I lit no candles last night, but those who did exposed their families to an increased risk of fire at a time when emergency crews were already over-burdened.
Greens think our entire energy supply chain needs to be re-thought. I'm sure there's always room for improvement. But when the lights go out, ordinary people do not sit in the dark and repent their environmental sins. Those fortunate enough to have access to gas-powered generators set them up, plug in the refrigerators that contain their insulin, and continue caring for newborns, cancer patients, and elderly parents.
Generators aren't quite as loud or as annoying as leaf-blowers. But trust me, they're in the same territory. As this new day blooms I'm looking forward to the last of them falling silent.
photographs courtesy of Kubb Miller


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Some years back, boss of Fiat Chrysler, Sergio Marchionne, was found eager to combine or partner with his conglomerate from somewhere.
Thereof, he witnessed a highlighting coming future that reveals every car company to make its self modeled structures, transmissions, engines and even parts that are much of wasted acquaintance.
This even becomes more reliable with the huge capital investments who are formulated to build up an electrified and autonomic sector.
Marchionne's dream is nearing to come true, where official reports declare that Fiat Chrysler is making a motion of 50/50 to merge with Group Renault of France.
Speaking of the step ahead to develop a better world, this is ready to make it the world's third-largest automaker in terms of production.
Furthermore, with the announcement on the website of FCA, this partnership looks after the chance to secure nearly 5 billion a year in relation with synergies, powertrains and also the merged areas of acceptance while improving the waste capital into neoteric EVs and other major or minor technologies.
Therefore, this plan occupies the minds of the people with the FCA and Renault to merge, while heading to FCA to become the new witnesses in the alliance still occupied, with Nissan and Mitsubishi.
Furthermore, the Japanese companies are also allied with Renault company for many years, yet did not plan to merge yet.
Where this mentions being the first tie-up ever happened with Fiat Chrysler's brands and Renault, the company Renault had earlier partnered with American Motors Corporation earlier, back in the 1970s.
This post was last modified on May 29, 2019 12:43 PM


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This list is a mere sampling of shelters we have worked with in the past. Please contact firstname.lastname@example.com if you need assistance locating a shelter for the donation of your completed Night Night Packages.
Bethesda Mission
2101 North Front Street, Bld. 1, Suite 301
Harrisburg, PA 17110
717-257-4442 x 223
Drueding Center
413 W. Master Street
Philadelphia, PA 19122
East End Cooperative Ministry
6140 Station Street
Pittsburgh, PA 15206
Emergency Shelter Project, Inc.
2700 Eighth Avenue
Altoona, PA 16602
The Salvation Army / Eliza Shirley House
1320 Arch Street
Philadelphia, PA 19107
The Salvation Army of Norristown
533 Swede Street
Norristown, PA 19401
610-275-4183 Attn: Erin
Washington Women's Shelter
One Main Street
Washington, PA 15301
Women's Help Center
809 Napoleon Street
Johnstown, PA 15907