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Generic Name : TADALAFIL Products Pills : 30 Pills Therapy : Sexual
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Possible Uses of Avanafil: Avanafil is a prescription medication used to treat erectile dysfunction in men. Avanafil belongs to a group of drugs called phosphodiesterase (PDE) inhibitors. These work by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection.
How to take Avanafil: Avanafil (Generic Stendra) comes as a tablet to take by mouth. The starting dose of Generic Avanafil Tablets (Avana) is 100 mg taken about 15 minutes before sexual activity on an as needed basis. Avanafil tablets are taken with or without food.
Based on efficacy and/or tolerability, the dose may be increased to 200 mg taken as early as approximately 15 minutes before sexual activity, or decreased to 50 mg taken approximately 30 minutes before sexual activity. Use the lowest possible dose that provides benefit.
Take Avana tablets no more than once a day. Do not take Avanafil (Generic Stendra) more often than once in any 24 hour period. This means that you can take your next dose only if 24 hours have passed since your last dose. Inform your doctor if Avanafil is not working well or if you experience any side effects.
Side Effects of Avanafil: The side effects of Avanafil (Avana Tablets) reported by greater than or equal to 2% of patients treated with this medication during clinical trials for use as needed are Headache, Flushing, Nasal congestion, Nasopharyngitis,and Back pain.
The side effects of Avanafil Tablets reported by greater than or equal to 1% of patients and greater than placebo are upper respiratory infection (URI), bronchitis, influenza, sinusitis, sinus congestion, hypertension, dyspepsia, nausea, constipation, and rash.
The following Avanafil side effects occurred in less than 1% of patients in the three placebo-controlled 3-month clinical trials:
Precautions When Using Avanafil: The following warnings and precautions have to be kept in mind before administering Avanafil Tablets (Generic Stendra) :
Cardiovascular Risks:
There is a potential for cardiac risk during sexual activity in patients with pre-existing cardiovascular disease. Therefore, treatments for ED, including Generic Stendra, should not be used in men for whom sexual activity is not advisable because of their underlying cardiovascular status.
Concomitant Use Of CYP3A4 Inhibitors:
Avana metabolism is principally mediated by the CYP450 isoform 3A4 (CYP3A4). Inhibitors of CYP3A4 may reduce Avana clearance and increase plasma concentrations of Avanafil.
For patients taking concomitant strong CYP3A4 inhibitors (including ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, and telithromycin), do not use Generic Avanafil Tablets (Avana).
Prolonged Erection:
Prolonged erection greater than 4 hours and priapism (painful erections lasting more than than 6 hours in duration) have been reported with other PDE5 inhibitors.
In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. If not treated immediately, penile tissue damage and permanent loss of potency could result.
Generic Avanafil(Avana Tablets) should be used with caution in patients with anatomical deformation of the penis, or in patients who have conditions which may predispose them to priapism (such as sickle cell anemia, multiple myeloma, or leukemia).
Effects On Eye:
Doctors must advise patients to stop use of all PDE5 inhibitors, including Avana, and seek medical attention in the event of a sudden loss of vision in one or both eyes. Such an event may be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), a rare condition and a cause of decreased vision including permanent loss of vision that has been reported rarely postmarketing in temporal association with the use of all PDE5 inhibitors.
Sudden Hearing Loss:
Use of PDE5 inhibitors has been associated with sudden decrease or loss of hearing, which may be accompanied by tinnitus or dizziness. It is not possible at present to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors. Any patient that experiences these symptoms should be advised to stop taking Avana Tablets(Generic Avanafil) and seek immediate medical attention.
Alpha-Blockers And Other Antihypertensives:
Doctors must discuss with patients the potential for Avanafil (Generic Stendra) to increase the blood pressure-lowering effect of alpha-blockers and other antihypertensive medicines. In certain patients, concomitant use of these two drug classes can lower blood pressure significantly leading to symptomatic hypotension (e.g., dizziness, lightheadedness, fainting).
Counseling Patients About Sexually Transmitted Diseases:
The use of Generic Avanafil Tablets (Avana) offers no protection against sexually transmitted diseases. Counseling patients about the protective measures necessary to guard against sexually transmitted diseases, including Human Immunodeficiency Virus (HIV), should be considered.
Drug Interactions of Avanafil: Avana tablets are contraindicated in patients with a hypersensitivity to Avanafil or any inactive ingredient present in Avana tablets.
Administration of Avana to patients using any form of organic nitrate is contraindicated. Administration of Avana tablets along with guanylate cyclase (GC) stimulators, such as riociguat are also contraindicated.
Overdose of Avanafil: If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include severe dizziness, fainting, or prolonged erection.
Other Information of Avanafil: Do not share this medication with others, since they may have a problem that is not effectively treated by this drug. Use of this drug does not protect against sexually transmitted diseases (e.g., HIV, Hepatitis B, gonorrhea, syphilis)
Missed dose of Avanafil: Not applicable.
Storage of Avanafil: Store at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture.
Generic Viagra® : SILDENAFIL CITRATE
Sildenafil Citrate is the chemical name of the active ingredient in Viagra®
Viagra® is the registered trademark of Pfizer Inc.
Generic Buy Viagra ™ 100 mg for erectile dysfunction
Viagra™ DRUG INFO
IMPORTANT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you.
SILDENAFIL - ORAL (sill-DEN-uh-fil)
COMMON BRAND NAME(S): Viagra™
USES OF VIAGRA: This medication is used to treat male sexual function problems (erection problems).
HOW TO USE VIAGRA: This drug is taken by mouth as needed between four hours and one-half hour before sexual activity (about one hour before is most effective). Take only as directed, usually once daily as needed. Sildenafil works along with sexual stimulation to help achieve an erection.
SIDE EFFECTS OF VIAGRA: Headache, flushing, stomach upset, nasal stuffiness, diarrhea and dizziness might occur. If these effects persist or worsen, notify your doctor promptly. Unlikely but report promptly: painful or other urination problems, vision problems, skin rash. Very unlikely but report promptly: chest pain, fainting, foot or ankle swelling. If you experience a painful or prolonged erection (lasting longer than 4 hours), stop using this drug and seek immediate medical attention. If you notice other effects not listed above, contact your doctor or pharmacist.
PRECAUTIONS WHEN USING VIAGRA: Before using this drug, tell your doctor your medical history, including: allergies (especially drug allergies), penis conditions such as fibrosis/scarring (e.g., Peyronie's disease), history of painful/prolonged erection (priapism), sickle cell anemia, blood system cancers (such as leukemia or myeloma), eye problems (retina diseases), kidney or liver disease, bleeding disorders, active stomach ulcers, heart disease, stroke, very high or low blood pressure. Limit alcohol intake, as it may aggravate side effects of this drug. Since this drug may cause dizziness, caution is advised when performing tasks requiring alertness (e.g., driving). To avoid dizziness and lightheadedness when rising from a seated or lying position, get up slowly. This drug is not to be used in women or children. The elderly may be more sensitive to the side effects of this drug, therefore caution is advised in this group.
DRUG INTERACTIONS OF VIAGRA: Tell your doctor of all nonprescription and prescription medication you may use, especially of: nitrate medications (e.g., nitroglycerin, isosorbide dinitrate), nitroprusside (any "nitric oxide donor" medicines), cimetidine, erythromycin, azole antifungals (e.g., itraconazole, ketoconazole), mibefradil, rifamycins (e.g., rifampin), high blood pressure medicines, certain HIV protease inhibitors (such as saquinavir, ritonavir, amprenavir), delavirdine. Do not start or stop any medicine without doctor or pharmacist approval.
OVERDOSE OF VIAGRA: If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include severe dizziness, fainting, or prolonged erection.
NOTES On VIAGRA: Do not share this medication with others, since they may have a problem that is not effectively treated by this drug. Use of this drug does not protect against sexually transmitted diseases (e.g., HIV, Hepatitis B, gonorrhea, syphilis)
MISSED DOSE OF VIAGRA: Not applicable.
STORAGE OF VIAGRA: Store at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture.
Generic Acyclovir™®: Acyclovir
Acyclovir is the chemical name of the active ingredient in Acyclovir™®
Chemical Name: ACYCLOVIR (ay-SYE-kloe-veer)
Other name brands for this medication
Zovirax, Sitavig
Possible Uses of Acyclovir: This medicine is an antiviral used to treat shingles, chickenpox, or genital herpes. It may also be used to treat other conditions as determined by your doctor.
Before using Acyclovir: INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. Inform your doctor of any other medical conditions including kidney problems, allergies, pregnancy, or breast-feeding.
How to take Acyclovir: Follow the directions for using this medicine provided by your doctor. TAKE THIS MEDICINE with food or milk if it upsets your stomach. DRINKING EXTRA FLUIDS while you are taking this medicine is recommended. Check with your doctor or nurse for instructions. STORE THIS MEDICINE at room temperature, away from light and moisture. TO CLEAR UP YOUR INFECTION COMPLETELY, continue taking this medicine for the full course of treatment even if you feel better in a few days. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Precautions When Using Acyclovir: DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or are allergic to any ingredient in this product. IF YOUR SYMPTOMS DO NOT IMPROVE WITHIN A FEW DAYS or if they become worse, check with your doctor. IF YOU ARE USING THIS MEDICINE FOR GENITAL HERPES, begin using it as soon as you notice symptoms (pain, burning, blisters) of an infection. Use a condom during sexual intercourse. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY because they may be more sensitive to the effects of the medicine. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. If you are or may be pregnant, check with your doctor for instructions on using this medicine during pregnancy. THIS MEDICINE IS EXCRETED IN BREAST MILK. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby.
Side Effects of Acyclovir: SIDE EFFECTS that may occur while taking this medicine include nausea, vomiting, diarrhea, or headache. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience mood or mental changes, blood in the urine, weakness or fatigue, or unusual bruising or bleeding. CONTACT YOUR DOCTOR IMMEDIATELY if you experience seizures. An allergic reaction to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.
Drug Interactions of Acyclovir: Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other. Check drug interactions
Overdose of Acyclovir: If overdose is suspected, contact your local poison control center or emergency room immediately.
Other Information of Acyclovir: If your symptoms do not improve or if they become worse, check with your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.
Generic Ampicillin™®: Ampicillin
Ampicillin is the chemical name of the active ingredient in Ampicillin™®
Chemical Name: AMPICILLIN (am-pi-SILL-in)
Other name brands for this medication
Principen, Omnipen
Possible Uses of Ampicillin: This medicine is a penicillin antibiotic used to treat bacterial infections.
Before using Ampicillin: Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking tetracycline antibiotics. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking birth control pills, "blood thinners", methotrexate, or injectable aminoglycosides. Inform your doctor of any other medical conditions including mononucleosis, allergies, pregnancy, or breast-feeding. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
How to take Ampicillin: Follow the directions for using this medicine provided by your doctor. TAKE THIS MEDICINE on an empty stomach 1 hour before or 2 hours after meals or snacks. STORE THIS MEDICINE at room temperature in a tightly-closed container, away from heat and light. TO CLEAR UP YOUR INFECTION COMPLETELY, continue taking this medicine for the full course of treatment even if you feel better in a few days. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Precautions When Using Ampicillin: DO NOT TAKE THIS MEDICINE IF YOU HAVE HAD A SEVERE ALLERGIC REACTION to a penicillin antibiotic (such as amoxicillin, ampicillin) or a cephalosporin antibiotic (such as Ceclor, Keflex, Ceftin, Duricef). A severe reaction includes a severe rash, hives, breathing difficulties, or dizziness. If you have a question about whether you are allergic to this medicine, contact your doctor or pharmacist. IF YOU EXPERIENCE difficulty breathing or tightness of chest; swelling of eyelids, face, or lips; or develop a rash or hives, tell your doctor immediately. Do not take any more of this medicine unless your doctor tells you to do so. IF MODERATE TO SEVERE DIARRHEA OCCURS during or after treatment with this medicine, check with your doctor or pharmacist. Do not treat it with non-prescription (over-the-counter) medicines. FOR WOMEN TAKING BIRTH CONTROL PILLS, this medicine may decrease the effectiveness of your birth control pills. To prevent pregnancy, use an additional form of birth control. THIS MEDICINE IS EXCRETED IN BREAST MILK. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby. IF YOU HAVE DIABETES, this medicine may cause false test results with some urine glucose tests. Check with your doctor before you adjust the dose of your diabetes medicine or change your diet.
Side Effects of Ampicillin: SIDE EFFECTS, that may go away during treatment, include nausea, vomiting, mild diarrhea, or irritation of mouth or throat. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience vaginal irritation or discharge. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.
Drug Interactions of Ampicillin: Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other. Check drug interactions
Overdose of Ampicillin: If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea, vomiting, and diarrhea.
Other Information of Ampicillin: If your symptoms do not improve within a few days or if they become worse, check with your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children.
Extra Super P Force – Sildenafil (Generic Viagra®) & Dapoxetine (Generic Priligy®) is a new combination tablet containing two of the most potent and effective pharmaceuticals proven to combat the major causes of male sexual dysfunction, Premature Ejaculation and Erectile Dysfunction.
P Force tablets contain 100mg sildenafil citrate and 100mg dapoxetine. For best results take 1 tablet 1-3 hours before sexual activity. Take only when needed and do not take more than one tablet per day.
Dapoxetine - Prligy for Premature Ejaculation
Dapoxetine also known as Priligy® is a new drug that has gained most of the people's interest and it is used as a treatment for premature ejaculation. The generic name for the drug is dapoxetine hydrochloride. It is useful for men as a treatment for their inability to sustain ejaculation and is suffering from premature ejaculation. It is one of a unique drug of its kind which regulates the ejaculation process in males. Premature ejaculation means the biological problem due to which a man ejaculates sooner than his actual carvings. It is a common male dysfunction for many men that need to be treated as soon as possible.Generic Name - Dapoxetine Brand Name - Priligy®
It is demonstrated that men who are taking dapoxetine priligy for the treatment of premature ejaculation have experienced momentous improvements in their sexual functions like ejaculatory control, attaining satisfaction with sexual intercourse, and increases in their intra-vaginal ejaculatory latency time (IELT). Dapoxetine is might be not available all across the countries like US, UK, Canada, Australia.
One should always take the dosages as per the prescription of a physician. It is important to follow the instructions to acquire the best results in just short span of time. By following the instructions, one can get more benefits by the regular usage of the drug. Instead of this there are prescribed many exercises so as to maintain body functions better than earlier.
Sildenafil (Generic Viagra®) is used to treat erectile dysfunction
Viagra™ is approved for the treatment of men who have difficulty having and maintaining an erection, otherwise known as impotence. If the nerves or blood vessels associated with this process aren't working properly, a man may not be able to get an erection. Viagra™ increases blood flow to the penis, so that when a man is sexually aroused, he can get and keep an erection. When the sexual encounter is over, the erection goes away.
Sexual dysfunction
Sexual dysfunction can take any shape from low sex drive to penile erectile dysfunction (ED). Though erectile dysfunction or impotence is a much discussed male sexual dysfunction problem, premature ejaculation (PE) often remains neglected and un-treated.
PE can occur to any age group and under any situation. Young guys find it most difficult to establish a relationship with a woman because of this and they find themselves not confident enough to perform well.
Premature Ejaculation (PE) can greatly affect a man and his partner's sexual satisfaction, ability to maintain relationship and of course a man's self confidence. Approximately 27-34 percent of men between all age groups get affected by PE. Most of the men ejaculate sooner then they expect.
Dapoxetine (Generic Priligy®) belongs to a group of medicines called "selective serotonin reuptake inhibitors" (SSRIs), used to treat premature ejaculation (PE) in men between 18 and 64 years old.
Dapoxetine is recently approved in Finland, Sweden, Austria, Portugal and Germany, Italy and Spain and is similarly expecting approval in several other EU countries.
Sildenafil Citrate
Sildenafil (Generic Viagra®) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil is in a class of medications called phosphodiesterase (PDE) inhibitors.
Sildenafil treats erectile dysfunction by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection.
Take only under doctors directions.
Viagra® Priligy® is a registered brand name of Pfizer U.S. Pharmaceuticals
Generic Antinaus™®: Promethazine
Promethazine is the chemical name of the active ingredient in Antinaus™®
Tablet Chemical Name: Promethazine.
Other name brands for this medication
Phenergan, Promethegan, Phenadoz
Possible Uses of Antinaus: Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (such as before/after surgery, motion sickness). It is also used to treat allergy symptoms such as rash, itching, and runny nose. It may be used to help you feel sleepy/relaxed before and after surgery or to help certain narcotic pain relievers (such as meperidine) work better. It may also be used for a short time to treat a runny nose due to the common cold. Promethazine is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain. Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.
These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).
Before using Antinaus: Before taking promethazine, tell your doctor or pharmacist if you are allergic to it; or to any other phenothiazines (such as prochlorperazine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
How to take Antinaus: Read the Patient Information Leaflet if available from your pharmacist before you start taking promethazine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually 2 to 4 times daily. For motion sickness, the first dose of promethazine should be taken 30 to 60 minutes before beginning travel. For allergies, this medication may be taken once daily at bedtime to avoid being drowsy during the day. When used before surgery, promethazine may be taken the night before or just before the procedure and may be continued afterwards as directed. If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
The dosage is based on your age, medical condition, and response to treatment. In children, the dosage may also be based on weight. Do not increase your dose or take this medication more often than directed.
Tell your doctor if your condition does not improve or if it worsens.
Precautions When Using Antinaus: Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, chronic obstructive pulmonary disease-COPD, sleep apnea), blood/immune system problems (such as bone marrow depression), high pressure in the eye (glaucoma), heart disease (such as irregular heartbeat), high blood pressure, liver disease, certain brain disorders (such as neuroleptic malignant syndrome, Reye's syndrome, seizures), stomach/intestine problems (such as blockage, ulcer), overactive thyroid (hyperthyroidism), difficulty urinating (for example, due to enlarged prostate).
This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Avoid alcoholic beverages.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Promethazine may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.
This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness. Liquid products may contain sugar and/or alcohol. Caution is advised if you have diabetes, liver disease, or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.
Children may be more sensitive to the side effects of this drug, especially slowed breathing (see Warning section). This drug can often cause excitement in young children instead of drowsiness. Special care should be taken when using this medication in children who have lost a lot of fluid (dehydration), those who have a family history of sudden infant death syndrome (SIDS), and those who are hard to wake up from sleep. Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation, or trouble urinating. Drowsiness and confusion can increase the risk of falling.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if promethazine passes into breast milk. It may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.
Side Effects of Antinaus: Drowsiness, dizziness, constipation, blurred vision, or dry mouth may occur. If any of these effects persist or worsen, tell your doctor. To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: fainting, slow heartbeat, mental/mood changes (such as hallucinations, nervousness, irritability, restlessness, confusion), unusual/uncontrolled movements (such as fixed upward stare, neck twisting, tongue movements), shaking (tremor), difficulty urinating, easy bleeding/bruising, signs of infection (such as fever, persistent sore throat), severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin. Get medical help right away if you have any very serious side effects, including: slow/shallow breathing, seizures. This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Get medical help right away if you have any of the following symptoms: fever, muscle stiffness/pain/tenderness/weakness, severe tiredness, severe confusion, sweating, fast/irregular heartbeat, dark urine, change in the amount of urine. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Drug Interactions of Antinaus: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray), metoclopramide. The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also affect breathing or cause drowsiness. Therefore, tell your doctor or pharmacist if you are taking other products such as alcohol, drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and narcotic pain relievers (such as codeine). Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. This medication may interfere with certain laboratory tests (including some pregnancy tests, glucose tolerance test, allergy skin testing), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.
Missed dose of Antinaus: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Overdose of Antinaus: If overdose is suspected, contact a poison control center or emergency room immediately.
Storage of Antinaus: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Other Information of Antinaus: DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.


text:
Va. gets $3.4M grant for veteran employment
June 13, 2014
RICHMOND, Va. (AP) — Virginia is getting a $3.4 million federal grant to help veterans better gain employment.
The U.S. Department of Labor says the Virginia is experiencing a record number of military personnel transitioning from active military duty into the civilian workforce.
Officials say that while there are numerous programs and services designed to assist veterans and their families, the funding will enhance coordination and alignment of those services.
The community college system and the Virginia Employment Commission will use the funds to identify promising practices and to explore, develop and test strategies to improve the employment outcomes of veterans.

subset: commoncrawl


text:
London Bridges
- Narrated by: Peter J. Fernandez, Denis O'Hare
- Series: Alex Cross, Book 10
- Length: 8 hrs and 13 mins
- Unabridged Audiobook
- Release date: 11-23-04
- Language: English
- Publisher: Hachette Audio
- Whispersync for Voice-ready
Publisher's Summary
Alex Cross is on vacation in San Francisco with his girlfriend, Jamilla Hughes, when he gets the call. The Russian supercriminal known as the Wolf claims responsibility for the blast.
Major cities around the globe are threatened with total destruction. The Wolf has proven he can do it; the only question is, can anyone stop him in time? Surveillance film of the blast reveals the presence of another of Alex Cross' most dangerous enemies, the ruthless assassin known as the Weasel.
World leaders have just four days to prevent an unimaginable cataclysm. Joining forces with Scotland Yard and Interpol, Alex fights his way through a torrent of false leads, impersonators, and foreign agents before he gets close to the heart of the crimes. Racing down the hairpin turns of the Riviera in the most unforgettable finale James Patterson has ever written, Alex Cross confronts the truth of the Wolf's identity, a revelation that even Cross himself may be unable to survive.
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- 02-27-05
What a ride!!!
Alex Cross is in fine form with his worldwide search for Wolf. It is a fun and suspenseful cat and mouse chase. The sound effects on the CD are awesome. I love the readers and accents. I do however miss his interaction with his partner from before he became a FBI agent. A very good listen overall - you should listen to Big Bad Wolf however before listening to this one.
16 of 17 people found this review helpful
- Sandylp
- SF Bay Area
- 03-13-05
A Wonderful Series
I've read or listened to all of the "Alex Cross" books by James Patterson and have loved them all. After each book, I'm ready for the next. While each book is a story in itself, the life of Alex and his family evolves throughout the series, so I'm glad I started with the first book, Along Came A Spider. Alex Cross is unpretentious and modest, but he always has more insight into a murder case than anyone else on the local police force or in the FBI. And in the end, he always gets his man...or woman. This book is the last book so far in the Alex Cross series. It's just as exciting and satisfiying as the previous 9 books. You won't be disappointed.
27 of 31 people found this review helpful
- Matthew
- Lithonia, GA, USA
- 04-21-07
Because so many of the reviews of this piece were less than stellar, I ordered it with lowered expectations. Much of the criticism was valid but I still found it to be an enjoyable listen. The main flaw was continuing the Wolf's character. There was no plausible explanation for him evolving into a Super Terrorist. Good fiction still needs a certain amount of believability. I think a new villain performing the same misdeeds would have made the work more credible. I think Mr. Patterson wrote this with the noble intention of giving his loyal readers a sense of closure. In many ways he accomplished this...but in the end I found myself asking the same question that I had after the final episode of Seinfeld, "Did he really have to go there?"
4 of 4 people found this review helpful
- Philip
- Thousand Oaks, CA, United States
- 01-23-06
Far Fetched
The Weasel? The Wolf? Is this an Alex Cross novel or an X-Men comic book. I haven't read or listened to an Alex Cross novel in quite some time and I was looking forward to this one, but it's sooo sophomoric!!!
And the sound effects between chapters are really, really annoying.
9 of 10 people found this review helpful
- Jorge
- Bethesda, MD, USA
- 04-17-05
I found this novel to be poorly plotted and superficial. There are a number of subplots that make no sense(like the kidnapping of a whole family for a few days only for them to reappear without explanation), or the complete lack of careful police work after each major bombing or disaster. Not believable.
4 of 4 people found this review helpful
- Tony
- Oakland, CA, USA
- 03-30-05
Better than what the critics have said about it
I thought "London Bridges" was a good "listen". The story hung together well and characters and situations seem to hang together well.
Does it compare with the quality of the author's other books? I think so. I was happy to see that the author spent more time with the storyline and with the "Wolf" than with "Alex" and his family and love life. I could see that he needed to build a foundation for Alex's love and family life in his previous books but he devoted just enough and not too much time with them in this one.
All in all a pretty good audiobook.
4 of 4 people found this review helpful
- Beverly
- Hurst, TX, USA
- 03-03-05
Lose the sound effects!
This could have been a very enjoyable listen had not the producers played with a VERY ANNOYING sound effect every few minutes to announce chapter titles. Had they reserved the sound effect for section breaks, it would have been interesting, but to blare them constantly throughout the book made me erase the thing and want to request a refund.
A Foley machine can be useful when used correctly; the use of it in this case ruined the book for me by constantly breaking the flow of the story. Don't waste your money on this one.
4 of 4 people found this review helpful
- Leticia A Olivarez
- Austin, TX United States
- 09-21-06
You won't miss much skipping this one..
I've enjoyed the entire Cross series, but this one was so "off" the mark. I kept waiting for the story line to get better - but it never did and it just dragged on -- the sound effects were corny. I enjoy listening to books as entertainment or to escape from the real world - even for an hour or so. Pulling in the 'world domination' and terrorist scenario just came out of left field. Hoping that the next book is better ~
3 of 3 people found this review helpful
- Mario Kroll
- Greater New York City Area
- 02-10-05
More of the same... and that's not so great.
I used to be a huge fan of Patterson's work until he branched off into romance and a number of predictable, repetetive short novels that are sold as separate installments rather than a complete work. This title is a prime example.
Alex Cross, once a compelling investigator with a believable background and psyche, now feels like the Rambo of the U.S. crime investigative world: he's called in to investigate on nearly every major case and pretty much always gets his guy.
While the plot is interesting in this particular book, global terrorism and suitcase nukes have been milked just about dry as a theme. I found the continuation of The Weasel as a major character a boring tangent. More problematic, howerver, was the transformation of The Wolf as a violent criminal that once focused primarily on the sex slave trade, but now masterminds and pulls off a hard-to-believe global blackmail plot where he, but for Alex Cross' intervention, is able to thwart the combined investigative power of all the world's major crime and terrorist fighting agencies almost single-handedly.
The plot feels shallow, it's hard to suspend disbelief, and it just isn't the same quality as vintage James Patterson. If you are looking for a quick, light action-crime read (or listen) this may work for you, but if you expect your characters to have any depth or the plot to surprise you or make you think, then I'd pass this one by.
17 of 21 people found this review helpful
- Nancy
- Northbrook, IL, USA
- 05-29-05
Alex Cross--getting boring
I have read all the Alex Cross books and enjoyed them, but Alex has finally begun to bore me. This one although relatively short, had me anxious for the conclusion. The sound effects at the end/beginning of each chapter were very annoying.
6 of 7 people found this review helpful


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House of Little Scientists – Water Permeability
House of Little Scientists – Water Permeability
Title: House of Little Scientists – Water Permeability
Original Title: บ้านนักวิทยาศาสตร์น้อย - ตอนน้ำซึม
Director: Warinnet Termsirikamol
Produced by: National Science Museum Thailand
Running Time: 11:33 Minutes
Country: Thailand
Year: 2016
Age Guideline:
Early Learners (5 – 8)
Category: Family Edutainment
Screened In: Vietnam, Myanmar, The Philippines, Gulf, Sudan, Egypt, Jordan, Palestine, Burkina Faso, Ethiopia, Namibia, Mali, Rwanda, South Africa
The flow rate of water is at the center of this episode of the "House of Little Scientists". The young researchers are observing that water can flow better through stones than through sand – and during their own experiments they find out why. The small researchers use their new knowledge right away in a very practical way: They are setting up irrigation sieves for the plants - with which they can individually adjust the water flow for each plant species.


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Jets use second-period blitz to soar past Flyers
Winnipeg, MB – Grant Clitsome, Kyle Wellwood and Evander Kane scored in a 2:06 span during a four-goal second period which lifted Winnipeg over Philadelphia, 4-1, at MTS Centre.
Bryan Little also tallied during the deciding frame and Blake Wheeler added a pair of assists for the Jets, who snapped a five-game losing skid.
"It was a big game. We were trying to get out of that funk or whatever you call it," Little said.
Ondrej Pavelec stopped 30-of-31 shots for the win.
Ruslan Fedotenko's tip of a Kent Huskins shot was the lone offense for the Flyers, who saw their four-game win streak and a chance to reach the .500 mark for the first time all season fall by the wayside.
"The first period went our way, in the third period the chances and shots were probably equal, but the second period is what cost us," said Flyers head coach Peter Laviolette.
Ilya Bryzgalov was pulled after allowing four scores on 16 shots in two periods. Steve Mason made his Philadelphia debut and turned away all nine Winnipeg chances in the third.
Clitsome tied the game on a wrister from between the circles with 7:22 left in the second, and Wellwood snuck a shot home from inside the crease only 27 seconds later for a 2-1 Jets edge.
It was a two-goal margin for Winnipeg when Kane walked out in front from the right of Bryzgalov, picked up his own rebound and lifted it home at 14:44.
A shot from the left wing by Little eluded Bryzgalov with 54 seconds left and the hosts hit intermission ahead 4-1.
Pavelec made 13 saves in the third to hold the visitors at bay, which included a pair of short-handed situations.
Huskins' floater from the left point near the boards hit the back of the net thanks to a Fedotenko tip with 8:53 remaining in the first period.
Under a minute prior to the score, Jets captain Andrew Ladd missed a breakaway chance by shooting wide.
Game Notes
The Jets improved to 8-14-1 this season when allowing the first goal, and the Flyers fell to 12-5-2 this season when scoring the first goal of the game ... Despite the loss, the Flyers won two of three in the season series ... Philadelphia hasn't won five in a row since March 1-10, 2012 ... Flyers forward Brayden Schenn played in his 100th NHL game (91 w/Philly) ... Bryzgalov made his 22nd straight start, most for a Flyers netminder since Pelle Lindbergh started 24 in a row during the 1984-85 season ... Fedotenko extended his point streak to five games (3G, 2A).


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At the Abbott house, Nick tells Jack he's looking for Phyllis and wonders if she's with Summer. Jack says he can wait and notes his agitated state. He thinks Nick is having trouble letting Summer go. Jack says he put out his family photos for Father's Day. Nick grunts. Jack talks about Kyle transitioning to think of him as his father. He assures Nick that Summer will come around; they did a great job with her.
Lady Luck's A Tease.
Summer suggests a plan to Kyle, Nick tells Phyllis the truth, and Michael and Lauren do homework.
At the penthouse, Phyllis sees Summer and Kyle off to On The Boulevard. She warns Kyle to take care of her little girl.
Phyllis arrives at the Abbott house asking what was so urgent? Jack tells her he thinks Nick's reacting to Summer's graduation. Jack talks about delivering Summer and then says he's sorry. Nick tells him to stop apologizing. Phyllis asks if this has to do with Cassie's death. Nick says he shouldn't have come.
At Boulevard, Billy talks to Carmine about why he gets drawn into poker. "Lady Luck's a tease...she gets you every time." Carmine comments about temptations. Billy greets Summer and Kyle, and says dinner's on the house. Kyle and Summer talk about her modeling career. Courtney texts Summer to ask if she's still a virgin. Summer smirks and suggests they skip dinner. She wants to get a hotel room together. Kyle smiles; she's fearless. Nearby, Jack greets Billy. He tells him Phyllis moved back in. Billy thinks Summer and Kyle will be happy about shacking up. Jack says he's fine with them dating but Nick doesn't like it.
Lauren and Michael arrive home from the therapist's office with homework. They mock the assignments. Lauren pulls a blindfold out of the envelope. They get laughing over a dice game and say what they admire about each other. Later, Michael has the blindfold on and has to follow her voice to navigate the room. He takes a big step and bangs into the coffee table. He snaps that maybe they're just not made for blind trust. Lauren says they have twenty-some days left. She doesn't know how to make this up to him. Michael tells her this is a start. She puts the blindfold on. When she nearly topples over the couch he catches her. She says she made a mistake. He says he knows.
Fen and Raven arrive at the party. He clarifies that she's not trying to set him up. They discuss what he did to Jamie. Fen says he's paying the price. She says now he know what it's like to be an outcast like them. Soon Fen is high and laughing with Raven. He gets a text from Carmine. Raven wonders what he wants - people always want something.
Phyllis follows Nick to the tackhouse. She wants to know what's going on with him. He wants her to leave it alone. She asks if something is going on with Summer. He says, "Yes, no, you don't want to know." Phyllis says he's scaring her. "Tell me!" Nick blurts, "I'm not Summer's father. Jack is." Phyllis takes the DNA results and reads them. She's confused. The original said he was a match. Nick says he lied to her; the samples were corrupted but he made it out like the first test was conclusive. Phyllis repeatedly says this can't be happening. "What have you done? What have you done!" They argue about him playing God and not being able to let go of Sharon. Nick says he knew that baby was his and that's all there was to it. He knew because of Cassie; he knew God couldn't be so cruel to take Cassie and then... Nick says it worked out how it was supposed to be. Phyllis points out that Summer's life is a lie; is that how it was supposed to be? She's upset that he used her for a Cassie substitute. Nick becomes angry and says he still considers himself Summer's father. Phyllis says he's like Adam and calls him a hypocrite. Nick denies he's like Adam; he didn't hurt anyone. Phyllis says she's hurt and this will kill Summer. She sobs. "Why are you doing this now?" Suddenly she realizes why; Summer's with Kyle and has only one thing on her mind.
At Boulevard, Summer ignores Phyllis' calls. Kyle asks about the hotel. It doesn't have to be tonight after graduation. Summer agrees; she'd like to see her friends tonight. They spot Jack. He tells them he didn't know they would be there. He hugs Summer for graduating. Later, Jack asks Billy what's going on; he's been on the phone all night. Kyle returns from dropping Summer off.
Still at the tackhouse, Phyllis finally reaches Summer who is at the penthouse. She tells her mother she took her advice; she'll be hitting up the parties instead. Phyllis voice cracks with relief. Phyllis tells Nick nothing happened. He's worried she's lying. She stops him from heading over there. Phyllis takes a call from Jack, who says he's at Boulevard with Kyle. Phyllis asks Nick. "What the hell are we going to do?"
Spoilers for Tomorrow on The Young and the Restless:
Dylan asks Chelsea if she's really okay. She says she's never been better.
Sharon tells Adam that deep down, he wants something more than meaningless sex. Adam asks, "Do I?"
Kevin asks Chloe if she's thinking about turning him in to the cops.
Please abide by the Soaps.com guidelines when posting and contact us if moderation is required. Read Y&R news, Y&R comings and goings, and Y&R spoilers!
Join Soaps.com on Twitter @soapoperafan, "like" Soaps.com on Facebook to dish on "The Young and the Restless," all the other soap operas, "Dallas," "Glee," "Grey's Anatomy," "Pretty Little Liars," "Revenge," "Vampire Diaries," and "Venice The Series."
- Candace Young


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The most efficient way to cook!
Induction cooktops utilize 90% of the energy produced compared to 50% used by other cooking methods. Induction recognizes the base of the cookware and directly heats only the diameter of the pot, so very little energy is wasted… saving you money while remaining eco-friendly.
Safest way to cook!
The induction cooktop surface remains cool to the touch since only the pot is heated. In addition, there are no open flames, smoke, or gas emissions making this an extremely safe and convenient portable cooking solution. It also has an automatic safety shut off feature for an added element of safety.
New features include:
7 power settings relating to various cooking functions, 2 Quick Launch buttons that immediately take you to your desired level and a "Quick Temperature Check" that displays the actual temperature.
Fastest way to cook
Considered one the most eco-friendly products for its energy-efficiency, induction cooks faster than gas or electric cooktops, reducing 50% of the cooking time. Heating and temperature adjustments are immediate, allowing you to go from a simmer to a rolling boil in a few seconds.
Easiest cooktop to clean
The flat smooth surface of the Portable Induction cooktop is made of high quality heat resistant glass making spills easy to clean. Spills do not bake on to the stay-cool surface, making cleaning a breeze!
Our new updated Portable Induction Cooktop with new features and 1800 watts of power.
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Temperature setting range from 140°F - 430°F
7 power level settings that are related to various cooking functions; (Melt, Warm, Med Low, Med High, Boil, Sear and Stir Fry).
Durable, easy to clean with a high quality Scott Ceran glass surface.
Includes 2 new "Quick Launch" buttons, "Boil" and "Warm, which take you directly to either desired power level.
A "Quick Temperature Check" button that displays the actual cooking temperature.
Lightweight and compact for easy handling and storage: 12"x14", 8 lbs.
Also includes a helpful quick reference operational guide, a user's manual, a DVD and a collection of delicious recipes.
Safe to use, unit will not generate heat and will shut off automatically if no cookware is detected.
Child Safety Lock system.
Requires standard household 110V connection.
UL approved


text:
April 02, 2014
By -, -
KANSAS CITY, Mo. – Neesha Thirumalaichelvam of Cumberlands (Ky.) has been named the NAIA Women's Tennis Player of the Week, the national office announced Wednesday. Thirumalaichelvam was selected based on her performances from March 24-30 and was chosen out of a pool of conference, independent and unaffiliated grouping award winners.
Thirumalaichelvam, a senior from Selangor, Malaysia, recorded a perfect week for the Patriots at No. 1 singles and No. 1 doubles. The Intercollegiate Tennis Association's (ITA) No. 3-rated singles player handled unranked opponents Kaelin Roberts of Georgetown (Ky.) (6-3, 6-2) and Summer Manning of Union (Ky.) (6-0, 6-0), and the ITA's No. 32-ranked singles player Angelica Sepulveda of Cumberland (Tenn.) (6-3, 6-3). With her partner Erin Hart, Thirumalaichelvam rattled off doubles wins over the top tandems from Georgetown (9-7) and Union (8-1) before unseating the ITA's No. 23-rated duo of Alena Gizdic and Angelica Sepulveda of Cumberland (8-4).
On the season, Thirumalaichelvam owns an 11-1 singles record and a 9-3 doubles mark.
For the complete Women's Tennis Player of the Week calendar, click here.
Nominees: Ekaterina Vezhekova, Tennessee Wesleyan; Whitney Vilmaure, Reinhardt (Ga.); Aziza Butoyi, Olivet Nazarene (Ill.); Katelyn Koll, Concordia (Neb.); Valerie Robinson, Northwestern (Iowa); Amanda Przymus, Morningside (Iowa); Lillian Blasquez, Missouri Valley; Sara Peck, Southwestern (Kan.); Brooke Vorhees, McPherson (Kan.); Mackenzi Choitz, Bethany (Kan.); Alyssa Kennedy, Georgetown (Ky.); Anna Tumanyan, Campbellsville (Ky.); Jessica King, Lindsey Wilson (Ky.); Elektra Hunter, Coastal Georgia; Lea Junggeburth, Mobile (Ala.); Paula Ortiz Couder, Embry-Riddle (Fla.); Justyna Wojcik, Northwood (Fla.).
2014 Women's Tennis Players of the Week
Week 1 (March 19): Valeria Podda, Georgia Gwinnett
Week 2 (March 26): Alyssa Fuentes, Davenport (Mich.)
Week 3 (April 2): Neesha Thirumalaichelvam, Cumberlands (Ky.)


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Add to Calendar
November 19, 2013 @ 1:00 am – 3:30 am
The Lincoln County Kickers Country Western Dance Club meet at the LC Fairgrounds Hall, Fairgrounds Road, Troy, Monday nights from 7 to 9:30 p.m. except holiday Mondays. The dance is open to the public. Contact Karen at 636-462-6465. Rick at 636-566-6277 or go to www.groups.yahoo.com/group/LCK_dance.


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Thermal detonator
Thermal detonators are issued to all stormtroopers and have no markings and individual codes, meaning that even if someone took a dead stormtrooper's thermal detonator, they would not know the activation code for it.
Thermal detonators are either round, cylindrical, or club like. (citation needed)
Thermal Detonator Strength
The SWEGWT states that thermal detonators use "fusion reaction" of a substance 'Baradium', and that thermal detonators shells are also designed to fragment. Thermal detonators, while being grenades, are also strong enough to be used as demolotion charges with enough force to blast a hole through 2 meters of permacrete (citation needed)
The SWEGWT states that the standard Imperial thermal detonator has a blast radius of 5 meters, with larger grenades having lethality ranges of 20 and even 100 meters. However, it is probable that these larger grenades are launched by either mortars or other artillery, since the blast radius would kill anyone in the immediate area, including the person who threw the detonator in the first place.
- Star Wars: Return of the Jedi: Leia, under the disguse of a bounty hunter, brandishes a thermal detonator, causing everyone in Jabba's throne room to cringe back in fear.
Expanded Universe
- Shadows of the Empire: Prince Xizor's palace on Coruscant was demolished by a thermal detonator.
- Star Wars: Knights of the Old Republic: When the player reaches the hangar that the Ebon Hawk is stored in, after defeating Davik Kang and Calo Nord, Calo Nord reveals a thermal detonator, saying "this thermal detonator will blast us all to bits" before being crushed by falling debris. It should be noted, that the hangar room this occurs in is very wide, and the player is easily standing some 20 feet away from him.


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1. Re: Group Hidden Elements after using show allPeter Spier Aug 6, 2012 10:21 AM (in response to MikeGondek)
As unbelievable as it seems, this is the first time I've ever seen a request like this, which makes me think it isn't somthing a lot of users have a need for.
2. Re: Group Hidden Elements after using show allMikeGondek Aug 6, 2012 11:35 AM (in response to Peter Spier)
The importance of this request has little to do with how many times someone has seen this, and more to do with synergy between the creative suite, and what people really need.
People who work on complex documents and catalogs could use this to help group elements better and quicker, rather than trying to use the CMD key sifting through overlapping elements. Try this on a complex document in both Illustrator and InDesign, before you attempt to shoot down this request, and you may realize something you are missing.
3. Re: Group Hidden Elements after using show allPeter Spier Aug 6, 2012 12:15 PM (in response to MikeGondek)
You missed the point here.
YOU find this a useful request, and can't believe the development and beta teams missed it. In fact, new features are basically driven by user request, with time and money allocated to those features that would help the largest numbers of users. This is usually diven by both the quantity of requests, and the presnetation of a good busiiness case why such a feature would be of benefit. I'm not saying what you propose has no value, just that in ten years you are the only user who has brought it up, and that leads me to suspect that it would have little support in the broader user community at large, especially if it meant some other features, like improvements to footnotes and indexing that are requested here hundreds of times a year, were to be put off because of it.
All of us have a tendency to see things from our own vantage point or frame of reference, and we tend to forget that frame of reference may be entirely unique to us. I assure you that the beta testers include users from many different types of users, including those that deal with large quantities of very complex documents and catalogs, and the ID engineering team is responsive to suggestions from these people far more than you would expect. It was your choice of saying that the lack of this feature was essentially unbelievable that set me off.
Frankly, I don't see a lot of difference between selecting a multitude of objects to hide them and selecting them to group, but if you can make a good case for it, please do. the official request form is at Adobe - Feature Request/Bug Report Form
4. Re: Group Hidden Elements after using show allMikeGondek Aug 6, 2012 1:21 PM (in response to Peter Spier)
Yes I find this a useful request, and that is why I posted this here. You have a right to disagree and I welcome that, but please make some point alteast. That I set you off, you may need to deal with that before posting on the forums.
Advantages to this method:
- Consistency between Illustrator & InDesign
- Ensurance that no wrong elements are added a group
- Ensurance that no elements are missed when making a group (EG: ®, ™, ©)
- Great way to work with sandwiched elements
- Confirm exisiting groups are accuarate, and add to them as needed
- Cleanup of duplicate elements left by others
- The end result is quick & better grouping.
As mentioned before to you, please stop providing the link to the bug request forum, I know where that is.
5. Re: Group Hidden Elements after using show allPeter Spier Aug 6, 2012 2:09 PM (in response to MikeGondek)
I read and answer dozens of posts a day as amoderator of these forums. I can't keep track of the details of every post that is made. And even if I did remember that you've posted that you know where the wish form is located, frankly, I don't care. These are public forums that are viewed by other people, many of whom don't know that link.
This particular forum is not a line to make a request, though it is commonly mistaken for that. The ONLY place that is monitored by Adobe employees for feature requests is the online for in the link. The purpose of this forum is to discuss the merits of a proposal.
So far you haven't shown me anything that establishes this as paricularly useful other than possibly the consitency argument, but I suspect that at least half of all ID users never open Illustrator or know it well enough to use your technique.
6. Re: Group Hidden Elements after using show allMikeGondek Aug 6, 2012 2:49 PM (in response to Peter Spier)
For what reason do you attempt to dismerit my feature request? Do you have a specific reason for wanting hidden elements to stay deselected after they are shown?
7. Re: Group Hidden Elements after using show allPeter Spier Aug 6, 2012 4:57 PM (in response to MikeGondek)
I'm saying I have no reason to want them selected (I often hide many things that should not be grouped together, or even selected when shown again), and I've never heard of anyone but you who does, so this doesn't appear to me to be the fundamentally obvious missing feature you seem to think it is. I'll repeat what I asked earlier: How is this fundamentally easier or better than simply grouping objects before you hide them? To hide them you have to identify them, so there's no big problem selecting them at the same time.
For those of us who are unfamiliar with how this works in Illustrator, would you mind providing some step by step instructions? I'm not seeing any way to select hidden objects in Illustrator at all, but I'm among those ID users who are not Illy power users.
8. Re: Group Hidden Elements after using show allPeter Spier Aug 6, 2012 5:13 PM (in response to Peter Spier)
Finally found it in the Help file. Object > Show all... and indeed it does select them. I personally find this somewhat frightening, but if you like it, great. I suppose it might be useful for quickly selecting and deleting objects that no longer belong in a drawing, but as a method for selecting things to group I think it leaves too much to chance (and gains nothing for speed).
9. Re: Group Hidden Elements after using show allMikeGondek Aug 6, 2012 7:14 PM (in response to Peter Spier)
Illustrator step by step process.
- Open up an existing document the more complex the better the example
- Decide on what you want to group (eg: a logo lockup, or a background with plenty of loose elements)
- Begin by hiding (CMD 3)the elements you want in your grou (, you may not be able to select all in one pass no worries that is why this process exists)
- Keep hiding until all elements are you desire in group are hidden
- (OPT CMD 3) to unhide
- CMD G to group
I proof alot of work on the job. When I use this technique, I routinely find junk underneath that leaks or does not even print, or missing elements like a product code. I get called over to computers to answer questions and see my best people take advantage of this, since even before InDesign was around. This is one of those things that every Adobe CS user could take adavantage of, but the importance is not realized until you have found the beauty of this, and how this helps you clean up sloppy documents with ease, and keep your own work tidy and professional.
10. Re: Group Hidden Elements after using show allPeter Spier Aug 7, 2012 4:38 AM (in response to MikeGondek)
Do you select with the mouse and use a shorcut to hide, or use the layers panel? In the layers panel I can select a collection of objects that cannot be easily marqueed as fast as I can hide them, probably faster than I can click on them and then hide.
Evidently you use this as a proofing techinique, and hiding objects can certainly be valid for that. I'm still not clear why there is value in having the objects unhidden and then immediately grouped? Are you saying something has changed about them that they should now be grouped when they should not have been previously? Users I know are in the habit of grouping as they work when it makes structural sense to do so, so there is no reason to need to group again.
If this were to be added as a feature, I wouldn't want to see it as a default, but perahps a preference item.
11. Re: Group Hidden Elements after using show allMikeGondek Aug 7, 2012 4:57 AM (in response to Peter Spier)
You select using the direct & select tool, and usng shift to add to selection, and CMD click to select items underneath others.
I use this as a proofing | production | designing technique, this is something that can be used by every Adobe CS user, ubfortuanlty you lose all the work of slecting in InDesign, cause the development team of InDesign were missing the expereince of a seasoned Illustrator user.
After particpating on these beta's in the past I know that the average level of people are not what they used to be when they used to send you the software fedex to be on the beta team. They just have too many people on the beta team rather than when they had a smaller group of certified expert users/authors, so working on basic stuff like this becomes a battle of a long explanation and losing people, and they go off topic often.
After unhiding in Illustrator the items are selected, so you can either group them, or just move on and deselect them.
You still are not grasping this, I may have to make a video.
12. Re: Group Hidden Elements after using show allPeter Spier Aug 7, 2012 5:13 AM (in response to MikeGondek)
No, I do grasp this. And I believe you find it useful, and it may well be in a power-user Illustrator scenario.
I've been using InDesign since it was realeased, and switched from Quark to ID to make my living at version 2.0. I've been involved with the development team, and I am considered to be an expert in ID, and I can tell you that in all of the time I've worked with ID, I've never missed this feature, and I've never seen anyone, including any Illustrator power user, other than yourself, suggest that it would help them.
Your other thread in the ID general discussions has received no comments at all after four days, a rarity on the ID forum, and I seem to be the only person other than you with anything more than passing interest in this thread. There are currently 147 views, some of which are you and I, but msot of those are probably unique visits. Does it say anything to you that none of those people has said "gee, I think that's a good idea, too, and I wish it was an InDesign feature"?
Go ahead and submit the request. You never know. My experience debating the merits of propsed new features tells me that you'll need more than you've presented to get it implemented, though.
13. Re: Group Hidden Elements after using show allMikeGondek Aug 7, 2012 6:45 AM (in response to Peter Spier)
Yes there were many views to the post and no response, and I have questioned that maybe this is not important to InDesign users. I do not believe that to be the case though, as I have asked a few other people and everyone of of them thought this was a great request and were as disapointed as I am that this exists. "Glad I am not working in InDesign then", "I requested that years ago myself", "that is why I rarely use hide in InDesign" are responses I had.
Out of curiosity why would you want items to be unselected, after you do show all? What benefit do you get with that being the default? Why would you want to lose that slection, where you could group, move, send to another layer, transform.
14. Re: Group Hidden Elements after using show allPeter Spier Aug 7, 2012 6:55 AM (in response to MikeGondek)
I hide things becasue I DON'T want them accidentally selected, or because I just don't want to see them. I have no reason to want to have them suddenly selected every time they are shown again so I have to wast effort to deselect.
I think there are some fundamental differences between the kinds of things that typically are done in Illustrator, where you work with myriad small objects that get in each other's way to make a larger illustration, and in ID where you mostly are dealing with aranging text and linked graphical elements (somtimes from Illustrator) on a page.
15. Re: Group Hidden Elements after using show allLaubender Aug 10, 2012 1:52 AM (in response to MikeGondek)1 person found this helpful
@Mike – I rarely missed that feature the last years, but that's because I am using Illustrator not that often. If I think about it more deeply, I could imagine that such a feature would be valuable for InDesign, too…
What would help you is a script, that can do what you want. Just written one and tested. But before posting code, let's discuss the functionality a bit more:
What is possible:
1. A script that addresses all hidden page items (provided they are not locked) on the current spread, pasteboard included, unhide them, group them and selecting the group.
2. A script that addresses all hidden page items (provided they are not locked) on the current spread, pasteboard included, deselect all currently selected page items, unhide the hidden ones and select them.
That's all. No grouping…
I find the second approach more valuable, because you have the choice what you can do with the selection: delete it, group it, move it around on the spread, move it to another layer etc.pp.
Also: how about locked page items that are hidden?
Would it be good to change the document preferences (if needed) so that you could select locked obejects?
How about a message in case the script detects locked and hidden page items that let you choose:
[ ] include locked and hidden page items
My script is in development, so I want to discuss the above points, before proceeding.
It's written in JavaScript (ExtendScript) so that it can be used on Mac OS or Windows OS.
And: you could assign a keyboard shortcut to the script…
16. Re: Group Hidden Elements after using show allMikeGondek Aug 10, 2012 8:28 AM (in response to Laubender)
Thank you for working on a script! Yes #2 is defintley better IMO.
So we are understanding each other. You cannot lock an item that is hidden. You can though have a hidden locked item if:
- The entire page is locked after items were hidden
- The item is hidden on a master page (InDesign should really give you a warning syaing "you have hidden itmes on a master page, do yo wish to reveal them and continue or delete them")
- anything else I am missing?
Unlocking items already works this way as your #2. An you hit it on the nose by deciding to do this by spread as lock does.
Being able to use a keyboard shortuct will be important, thank you! I would edit my exisitng keyboard shortcut for opt cmd 3.
Does not matter to me about the warning of hidden locked items, won't really run into that as don't have a reason to hidden locked items.
I am working on a >1100 page catalog, with 4 - 9 products per page. So being able to group will be great so we can fit each product into 1, 1.5, or 2 colums. Each product possibly has a logo, product number, icons for , callout text violator, various icons representing claims, specifications table. So being able to group all these per all 6000 products will make shuffling around and resizing easier. In many cases I can drag a selection frame and group, but missing one small icon or product number is frustrating, adn being able to add hide as a checkpoint really helps us out.
17. Re: Group Hidden Elements after using show allLaubender Aug 11, 2012 8:47 AM (in response to MikeGondek)
anything else I am missing?
@Mike – unfortunately, yes!
You can change the preferences for locked objects, so that you can select them.
Therefore it's possible to generate single objects that are locked AND hidden.
And a script should deal with that case. Maybe not now, but in the future you are changing your habbits and working with different preferences and objects that are locked and hidden ;-)
Ok. I will expand the script in the next days so that it could detect hidden and locked objects, and if so, and only then, will ask the user, if thiese objects should be made visible and selected too…
That brings me to my final question: what version of InDesign do you use on what OS platform?
18. Re: Group Hidden Elements after using show allMikeGondek Aug 11, 2012 9:52 AM (in response to Laubender)
Will look into that prefernces for making locked and hidden objects. Do not see a use at the moment for that, but you never know what you can discover with an open mind.
Mac platform.
Thank you again, and no hurry I get paid by the hour on this job.
19. Re: Group Hidden Elements after using show allPeter Spier Aug 11, 2012 12:01 PM (in response to MikeGondek)
Prior to the improved layers panel in CS5 Locked objects could always be selected. With the changed panel came a behavior change to not being able to selct locked objects (as in Illustrator), but during testing I raised the issue that this broke many tempaltes and workflows where a placeholder frame would be locked for position. If you can't select it you can't place content into it or edit the content, so it was made a preference item.
20. Re: Group Hidden Elements after using show allMikeGondek Aug 14, 2012 10:07 AM (in response to MikeGondek)


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Preventing guns from reaching criminals' hands and protecting law-abiding citizens' rights to bear arms were the two constant themes in Monday's public forum in Fall River on reducing gun violence in Massachusetts.
Preventing guns from reaching criminals' hands and protecting law-abiding citizens' rights to bear arms were the two constant themes in Monday's public forum in Fall River on reducing gun violence in Massachusetts.
The forum, which was held at the Fall River Police Department, drew a small number of private citizens, along with the elected officials and law enforcement officers who discussed possible solutions that a comprehensive gun-control bill could offer.
"The law-abiding firearm owner is not the problem. A lot of the legislation that has been proposed really attacks the lawful firearm owner, and that's not what we want to do," said state Rep. Alan Silvia, D-Fall River, who co-hosted the fifth "Listening Tour" stop in Massachusetts to hear input on pending gun legislation.
Since last December's mass shooting at Sandy Hook Elementary School in Newtown, Conn., where 20 children and six adults were killed, lawmakers on Beacon Hill have filed more than 65 bills to address gun violence. Some of those bills would mandate background checks at gun shows, tighten access to high-powered rounds of ammunition and require GPS locators on guns.
State Rep. Harold P. Naughton, Jr., the House Chairman of the Joint Committee on Public Safety and Homeland Security, said Monday that he hopes to condense all those the bills into a comprehensive legislative package by September.
"We want to give every stakeholder a chance to be at the table so we can hear from them," Naughton said.
Most of the input during Monday's forum at the police station focused on stopping illegal guns from reaching criminals, and on possible solutions to trace those weapons' origins.
Bristol County District Attorney C. Samuel Sutter said his office conducted a study in 2009 that found illegal firearms were used in about 95 percent of shootings in the county. He said lack of resources is a challenge when adding that he would like to be able to assign someone in his office to trace those firearms.
"The people committing crimes in Massachusetts are not legally licensed gun owners. They are not returning to the crime scenes with their FID cards," Fall River Police Chief Daniel S. Racine said.
Ensuring school safety and coming up with a scheme to balance medical privacy with mental health considerations for gun owners were also discussed, as well as the idea to streamline the gun licensing process for prospective firearm owners, who can wait up to 20 weeks in some cases to have their applications processed at their local police department.
Racine said the licensing process can be "streamlined" and the mental health component "tweaked." Officials said police could be given greater leeway to investigate an applicant's history to know whether they were ever committed for a mental illness.
Aaron Pasteris, a Taunton resident, said Massachusetts already has a "de-facto" background check in the licensing process, which he said could be done by clerical staff instead of a full-time police officer.
Pasteris also said the court system is often a "revolving door" for people
charged with gun crimes and added that law-abiding citizens "don't want to be penalized for what criminals are doing because we are not criminals."
"A restriction on the lawful is never going to touch the criminal," Pasteris said.
Naughton called Monday's forum the "most substantive" of the listening tour stops he has hosted. Naughton said he expects to hold three more informal discussion forums to go along with the official public hearings on the issue.
Email Brian Fraga at email@example.com.


text:
Walt Whitman
Walt Whitman (31 May 1819 - 26 March 1892 / New York / United States)
» Click to list general statistics » OR, select a date :
Give Me The Splendid, Silent Sun
GIVE me the splendid silent sun, with all his beams full-dazzling;
Give me juicy autumnal fruit, ripe and red from the orchard;
Give me a field where the unmow'd grass grows;
read more >>
- Hits: Number of visitors who read the poem on the given date.
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Have you ever been killed in a Call of Duty game only to watch the kill cam and see that the other player was watching the door? It is no secret that camping is running rampant in the Call of Duty community and based on the track record of the series, Black Ops isn't going to be any different. It doesn't have to be like that, however, and here is one way camping could be quelled.
Just playing Devils Advocate here but, maybe the camping is part of what makes Call of Duty so popular.
It lets people with no skill get easy kills.
Its always weird the way it's the guy shooting the dope who doesn't have the skill to check a door before he blindly runs through it is considered the one with no skill!!
camping is a part of war and war games. to an extent of course.
not just for snipers. its a viable tactic. its one thing to just sit behind a staircase. i get why people hate that. but two reflemen covering a door while another two snipers cover the window giving info of what they see to their team on the field is not camping. that's strategic.
its one of the reasons i stopped playing call of duty. its a run and gun fest.
I think they are looking at the phenomenon "camping" a bit wrong. Even tho camping is more excessive in some games than others, I think developers in a whole need to examine the term and come up with a good solution or something to handle this.
I don't got solutions or even ideas how to address this, and many will even say it doesn't need to be addressed, but I wish a smart solution would be thought of in the most FPSes out there.
Camping is how a person plays. There are snipers, campers, rushers, and cautious peeps.
REAL snipers stay back and hardscope across a map.
Campers sit and wait for someone to go by them or near them.
Rushers run carelessly into a fight and get angry when killed by a camper or sniper.
Cautious players dont rush and dont camp either. They are sorta in the middle. Doing a little of both.


text:
I ache for running
By Foaad Khaknezhad
1 Nov 2010
Padide means Phenomenon; how did you become such a wonder?
I started with Swimming and Gymnastics. From the age of 7 I was introduced to track and field. I became a volleyball player with my mother's encouragements.
What made you want to be an athlete; in our country girls are less drawn to sports compare to boys?
My mother is an athlete. She was both a runner and volleyball player. She was a track and field referee and she believed that everyone should learn the athletics as a base for sports. So I started with Swimming and track and fields.
When did you start running?
My gymnastic class was next to the running tracks. I hate gymnastics. One day I ran from the class and went to the running tracks. My mom then registered me for the track and fields.
Did you face any obstacles in your way?
When I was a kid there were no sports facilities for women. I remember when they close the doors of Shahid Keshvary's gymnasium to women. My mother and a couple of other women protested and asked the manager to give women athletes two hours a day and until today from 2 to 4 pm the gymnasium is only open to women.
What about people, you neighbors and others?
Since my parents were always supportive there were no problems with the public. But my father believes that sports are good until a certain age and then I should start my own life and get married. My father once could see my race in the Islamic countries championship. I carried the torch and he was crying. It was the last time he ever came to my games.
Is he passed away? What happened?
A: Yes he passed away 10 days to the West Asian Championship. I attended the competitions and I go to the first place and third place in my competitions.
What do you wish for in your athletic career?
I never aimed to become a champion; the most important thing for me is always the spirit of sports. I love to become an international track and field's coach.
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More Interviews
INDIA - Portraits of People
By Kristian Bertel — 13 Nov 2012
Kristian Bertel's images have been shown as photo essays online - documenting many aspects of the daily life particularly in India.
By Indra Widi — 11 Dec 2011
A Silent dialogue in distortion and transparency of the space and time.


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NEW YORK (AP) -- Optimism that the world economy is improving pushed the euro to a nine-month high against the dollar Friday.
Traders sold the yen, pushing it to its lowest point against the dollar in over two years, after Japan announced a new stimulus package to boost its economy.
On Thursday, European Central Bank President Mario Draghi said he expects the economy in the 17-country bloc that uses the euro to recover slightly in late 2013.
The euro rose to $1.3338 late Friday from $1.3254 late Thursday. The euro jumped as high as $1.3365, its highest point against the dollar since April 3, 2012.
In Japan, new Prime Minister Shinzo Abe announced a $224 billion stimulus package Friday to help the country's economy. The dollar rose to 89.20 Japanese yen from 88.19 Japanese yen late Thursday. The dollar rose as high as 89.434 Japanese yen Friday, its highest point against the dollar since June 28, 2010.
In other trading Friday, the British pound fell to $1.6121 from $1.6153.
The dollar fell to 0.9130 Swiss franc from 0.9145 Swiss franc and to 98.41 Canadian cents from 98.42 Canadian cents.
Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.


text:
Paint Party Invitation
Custom, handmade painter's palette invitation for your little artist's party! This invitation is made with heavy card stock, puff paint and a paint brush. Includes a coordinating 5×7 inch envelope. Alternative color combinations available for backdrop.
For more inspiration and photos, visit the blog post for our Painting Party.


text:
A nine-member strong Polish mountaineering expedition led by famous Polish veteran mountaineer, Krzysztof Wielicki, left for Skardu for their attempt to make the first winter ascent of 8,047 metre high Broad Peak in the Baltoro region.
Krzysztof Wielicki, who is now 62 years old, was the fifth mountaineer to climb all 14 peaks rising above 8,000 metres between 1980 and 1996. The expedition also includes young and strong mountaineers including Adam Bielecki and Janusz Golab who created history by making the first winter ascent of Gasherbrum I (8,068 metres) on March 8, 2012. From Pakistan side the expedition is being accompanied by famous professional mountaineer and
member Alpine Club of Pakistan Shaheen Baig who hails from Shimshal, Hunza, Gilgit-Baltistan. Baig has climb of three peaks rising above 8,000 metres including K-2 to his credit and has taken
part in several winter expeditions to Gasherbrum II and other peaks.
Alpine Club of Pakistan President Lieutenant Colonel (r) Manzoor Hussain in a message to the expedition has wished them success and safe return after their arduous adventure. It may be noted that during winter the Karakoram high peaks experience severe cold conditions with strong winds to the range of up to 100 kilometres an hour with temperatures dropping to 70 degrees below freezing. It may be recalled that first winter ascent of Gasherbrum II (8,035 metre) was made by an international team lead by Mr Simone Moro and that of Gasherbrum I (8,068 metres) was made in March 2012 by a Polish Expedition led by Artur Hajzer.
In addition to the Polish expedition to Braod Peak, five other foreign expeditions shall be attempting to make first ascent of the killer mountain Nanga Parbat (8,125 m) during this winter climbing season.


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Imetelstat as Maintenance Therapy After Initial Induction Chemotherapy in Non-small Cell Lung Cancer (NSCLC)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01137968
Recruitment Status : Completed
First Posted : June 7, 2010
Last Update Posted : January 26, 2016
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this is to evaluate the efficacy and safety of imetelstat (GRN163L) as maintenance therapy for patients with advanced stage NSCLC who have not progressed after 4 cycles of platinum based therapy.
Participants will be randomized in a 2:1 ratio to imetelstat + standard of care versus standard of care alone. Participants who received bevacizumab with their induction chemotherapy will continue to receive bevacizumab on this study.
|Condition or disease
|Non-small Cell Lung Cancer
|Drug: imetelstat Drug: Bevacizumab
|Phase 2
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|116 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Randomized Phase II Study of Imetelstat as Maintenance Therapy After Initial Induction Chemotherapy for Advance Non-small Cell Lung Cancer(NSCLC)
|Study Start Date :
|May 2010
|Actual Primary Completion Date :
|September 2013
|Actual Study Completion Date :
|September 2013
Experimental: imetelstat plus standard of care
imetelstat plus standard of care (bevacizumab or observation)
Drug: imetelstat
9.4 mg/kg over a 2 hour IV infusion on Day 1 and Day 8 of each 21 day cycle until disease progression.
Other Name: GRN163L
Drug: Bevacizumab
Dosage and duration will be according to the FDA-approved bevacizumab package insert. Bevacizumab will be administered on Day 1 of each 21-day cycle.
Other Name: Avastin
Standard of care
Bevacizumab or observation
Drug: Bevacizumab
Dosage and duration will be according to the FDA-approved bevacizumab package insert. Bevacizumab will be administered on Day 1 of each 21-day cycle.
Other Name: Avastin
- Progression-free survival [ Time Frame: From randomization to documented disease progression or death, whichever occurs earlier, through the end of the study period (8 mos. after the last participant is randomized) ]Defined as the time from randomization to documented disease progression or death, whichever occurs earlier,as determined by the Investigator's assessment according to RECIST, or death from any cause, whichever occurs earlier.
- Objective response [ Time Frame: Occurring post randomization through end of study period (8 mos. after the last participant is randomized) ]Objective response (partial response plus complete response) occurring post-randomization as determined by the Investigator's assessment according to RECIST criteria using post-induction tumor dimensions as a baseline.
- Time to all-cause mortality [ Time Frame: From the date of randomization through end of study period (8 mos. after the last participant is randomized) ]Defined as the time from the date of radomization to death from any cause during the study period.
- Safety and tolerability [ Time Frame: From the date of randomization through the end of the study period (8 mos. after the last participant is randomized) ]Safety and tolerability will be assessed by the incidence, nature, and severity of adverse events, laboratory abnormalities, and vital signs.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Signed informed consent.
- Ability and willingness to comply with requirements of the study protocol.
- Male or female, age 18 or over.
- Histologically or cytologically confirmed diagnosis of NSCLC
- Stage IV (using the 7th edition of AJCC, or wet IIIb / IV using the 6th edition), or recurrent locally advanced disease not amenable to radiation or surgery with curative intent and not amenable to concurrent chemoradiation.
- Patients have completed four to six cycles of platinum-based chemotherapy doublet for first line, advanced NSCLC, with no evidence of disease progression according to RECIST version 1.1. Adjuvant chemotherapy greater than one year prior to progression is allowed.
- Patients are willing and able to continue treatment with bevacizumab, if they received it with their platinum based chemotherapy.
- ECOG performance status 0-1
Adequate bone marrow reserve as measured by ANC ≥ 1500/mm3, hemoglobin
≥ 9 g/dL, platelet count ≥ 75,000 μL. Must be measured ≥ 1 week after last transfusion of blood products and/or last dose of hematopoietic growth factor.
- Prothrombin time (PT) or INR or aPTT ≤ 1.5 x ULN.
- Serum creatinine < 1.5 mg/dL or creatinine clearance > 45 mL/min.
- Urinalysis with < 2+ protein or urinary excretion of < 2 g of protein/day (for patients to receive bevacizumab).
- AST (SGOT) and ALT (SGPT) < 2.5 x the ULN, (AST (SGOT) and ALT (SGPT) < 5 x the ULN if documented liver metastases).
- Serum bilirubin < 2.0 mg/dL (patients with Gilbert's syndrome: serum bilirubin < 3 x ULN).
- Alkaline phosphatase < 2.5 x ULN (patients with documented liver or bone metastases, alkaline phosphatase ≤ 5 x ULN).
- No other obvious related major organ toxicities which would compromise the patient's ability to participate in a clinical trial of a novel agent.
- Patients may have received prior radiation therapy for local or locally advanced disease providing that any clinically significant adverse effects associated with prior therapy have recovered to Grade 1 or less.
- Women of childbearing potential must have a negative serum pregnancy test and agree to use effective birth control during and for 12 weeks after the last treatment with imetelstat.
- Males must agree to use effective birth control for themselves or their partner during and for 12 weeks after the last treatment with imetelstat.
Exclusion Criteria:
Patients who meet any of the following criteria will be excluded from screening and study entry:
- Patients who are not eligible for induction therapy with a platinum based chemotherapy doublet.
- Patients who have received, or are scheduled to receive pemetrexed or erlotinib as maintenance therapy.
- Patients receiving bevacizumab must not have a recent history of hemoptysis ≥ ½ teaspoon of red blood or history of ≥ 2 g/24 hr urine protein while receiving prior bevacizumab, or squamous cell histology.
Patients will be excluded from being randomized if any of the following criteria apply:
- Last dose of induction chemotherapy < 21 days prior to randomization or > 42 days prior to randomization
- History of pulmonary hemorrhage (> 1 teaspoon) within the 4 weeks prior to randomization.
- Anti-platelet therapy within 2 weeks prior to randomization, other than low dose aspirin prophylaxis therapy.
- Therapeutic anticoagulation therapy except for low dose warfarin (e.g., 1 mg by mouth per day).
- Radiation therapy within 3 weeks prior to randomization (palliative radiation therapy is allowed, provided that sites of bone marrow production, i.e. iliac crests are not in the radiation field)
- Major surgery within 4 weeks prior to first study drug administration (central line placement is allowed)
- Active central nervous system (CNS) metastatic disease. Patients with stable CNS disease following completion of radiation therapy and/or surgery are eligible.
- Any other active malignancy
- Active or chronically recurrent bleeding (e.g., active peptic ulcer disease)
- Clinically significant infection
- Active autoimmune disease requiring immunosuppressive therapy
Clinically significant cardiovascular disease or condition including:
- Congestive heart failure (CHF) requiring therapy
- Need for anti-arrhythmic therapy for a ventricular arrhythmia
- Severe conduction disturbance
- Angina pectoris requiring therapy
- Medically uncontrolled hypertension per the Investigator's discretion
- Myocardial infarction within 6 months prior to first study drug administration
- New York Heart Association Class II, III, or IV cardiovascular disease
- Any other severe, acute, or chronic medical or psychiatric condition, laboratory abnormality, or difficulty complying with protocol requirements that may increase the risk associated with study participation or study drug administration or may interfere with the interpretation of study results and, in the judgment of the Investigator, would make the patient inappropriate for the study.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01137968
Show 33 Study Locations
|Principal Investigator:
|Joan Schiller, MD
|University of Texas
|Responsible Party:
|Geron Corporation
|ClinicalTrials.gov Identifier:
|NCT01137968 History of Changes
|Other Study ID Numbers:
|First Posted:
|June 7, 2010 Key Record Dates
|Last Update Posted:
|January 26, 2016
|Last Verified:
|March 2015
Keywords provided by Geron Corporation:
imetelstat sodium
telomerase inhibitor
telomerase inhibition
maintenance therapy
non-small cell lung cancer
relapsed non-small cell lung cancer
advanced non-small cell lung cancer
NSCLC, cancer stem cells
post induction chemotherapy
Additional relevant MeSH terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors
Antineoplastic Agents


text:
An important part of a complete heartworm prevention program is testing. Testing ensures that your pet is free of adult heartworms, and ready to start or continue on heartworm preventive medication. The American Heartworm Society (AHS) estimates that only 50% of dogs in areas where heartworm occurs are actually on heartworm preventives. Of those prescribed heartworm prevention products, only about 75% receive all of the doses. Since heartworm continues to be a fatal disease and pet owners' compliance with heartworm prevention is less than optimal, the AHS recommends the following guidelines for testing and giving preventives.
Types of Tests
There are different types of heartworm tests, which require a blood sample from your pet.
Antigen Tests
These tests detect specific antigens from adult female heartworms, and are used with much success to detect canine heartworm infection. Currently, tests are available as in-clinic tests, as well as at many veterinary reference laboratories. Most commercial tests will accurately detect infections with one or more mature female heartworms that are at least seven or eight months old, but they generally do not detect infections of less than five months duration.
Antibody Tests
In the late 1970's and early 1980's, several canine heartworm antibody tests were developed and introduced, but such tests for dogs have been largely replaced by the more useful antigen tests. The antibody test is the most common test used in cats, however.
There is no maternal transfer of protection against heartworms. If puppies or kittens are exposed to mosquitoes carrying infective larvae, they can be infected. In areas with year-round potential for infection, puppies and kittens should be started on a heartworm preventive by no later than eight weeks of age.
In the battle against heartworm disease, it is better to be "safe than sorry." Heartworm testing is an important part of a heartworm prevention program. Your veterinarian will help you determine the right testing schedule for your pet. Negative results help determine your pet's overall health and rule out the presence of heartworm disease.
Learn what every pet owner needs to know about heartworm prevention:
visit our Special Heartworm Disease Information Section!