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text:
PHILADELPHIA — Eli Manning delivered the knockout blow after Michael Vick got knocked out of another game.
Manning threw four touchdown passes, including two to Victor Cruz, and the New York Giants beat the Philadelphia Eagles 29-16 Sunday.
Vick started despite suffering a concussion in last week's 35-31 loss at Atlanta. He left with a broken right hand in the fourth quarter after helping the Eagles overcome a 14-0 first-quarter deficit to take a 16-14 lead.
It's uncertain how long Vick will be out. He'll have a CT scan Monday.
"I don't know anything right now except my hand is broken," Vick said.
Vick wasn't happy with the hit, either. He completed a 23-yard pass to Jeremy Maclin before taking a hard shot from Chris Canty.
"I felt I got hit late. No flag," Vick said. "At some point something catastrophic is gonna happen. Not to blame the refs, but more precautions should be taken. I'm on the ground all the time in the pocket."
Without their Pro Bowl quarterback, the Eagles (1-2) hardly look like the "Dream Team" that entered the season with Super Bowl or bust expectations.
Manning threw a pair of TD passes in the fourth quarter to rally New York. The Giants (2-1) have won two in a row and snapped a six-game losing streak against their division rivals.
"It's always good to beat those guys, especially here," Manning said. "They have good players and we new we had to come in with the same game plan as last year and just finish it this time."
In their previous meeting at the Meadowlands last December, the Eagles rallied from a 21-point deficit with 8:17 left, and won 38-31 on DeSean Jackson's 65-yard punt return for a touchdown on the last play.
The teams traded a lot of trash talk in the offseason and during the week. The Giants backed it up.
"I think I responded today," Giants safety Antrel Rolle said. "I'm not scared of anyone on the field. I thing it's more mental than physical. They tried to get in my head sticking their hands in my face, blocking me after the play, but if they want to fight, I'll fight anyone, but in between the lines, I'm too smart to get thrown out of the game."
Manning threw for 254 yards, and Ahmad Bradshaw ran for 86 and had 53 more receiving, including a TD. Filling in because Mario Manningham and Domenik Hixon are out, Cruz had three catches for 110 yards and his first two career scores.
Aaron Ross, who was benched in the second half of New York's win over St. Louis last Monday, had two interceptions that led to 14 points.
LeSean McCoy had 128 yards rushing and one TD for Philadelphia, which has blown two fourth-quarter leads in consecutive games.
After McCoy was stopped for a 3-yard loss by Michael Boley on fourth-and-1 from the Giants 43, Manning drove New York in for the go-ahead score. He tossed a 28-yard TD pass to a well-covered Cruz to put the Giants up 20-16. Jacobs ran in for the 2-point conversion to make it 22-16.
Cruz outfought Nnamdi Asomugha and Jarrad Page to make the catch near the goal line and fell into the end zone, losing the ball after he crossed.
"It means the world to me because a lot of people were saying our receivers were down and who would step up and I was happy to be that guy that stepped up to help my team," Cruz said.
Mike Kafka replaced Vick on the ensuing possession and Ross intercepted his first pass. Manning connected with Bradshaw for an 18-yard TD pass to put the game away.
Vick finished 16 of 23 for 176 yards and one interception. He ran for 31 yards. Vick looked shaky early, but made a few nice throws before leaving.
He didn't seem all that happy after the Eagles kicked a field goal to pull within 14-13 at halftime. Vick looked angry as he walked off the field, waving his arms and pointing. Jackson tried to calm him down, but Vick didn't seem interested in listening.
"He was just frustrated with the offensive line," Jackson said.
The Eagles dominated time of possession by a nearly 3-1 margin throughout the first three quarters, but didn't take the lead until the final minute of the third when Alex Henery kicked a 21-yard field goal.
It was a disappointing end to a drive that began at the 10 and stalled at the Giants 1. The Eagles had a first down at the 2 and failed on four runs to get it in. McCoy didn't get one of the handoffs.
Philadelphia got a lucky bounce on that drive. Vick ran 8 yards for a first down on third-and-6 from the 14. Vick fumbled at the end of the run, but the ball bounced forward and left tackle Jason Peters caught it in the air. Peters rumbled for 5 more yards.
Vick left the game for X-rays on his right hand after that drive and was temporarily replaced by Kafka. But he returned during a time out while Kafka was in the huddle and played one more drive before going to the bench.
Steve Smith made a crucial mistake on the first ball that came his away against his former team. Smith left the Giants for Philadelphia and returned ahead of schedule from knee surgery to be ready for Week 1. Vick's third-down pass on Philadelphia's first drive hit Smith in the hands and bounced in the air to Ross, who caught it at the Giants 8. Ross returned the interception 19 yards, and Manning needed six plays to lead New York into the end zone.
Rookie linebacker Casey Matthews, who was moved from the middle to the weakside spot earlier in the week, bit badly on a play-fake that allowed Jacobs to get wide open. Manning's perfect throw hit him in stride and the Giants went up 7-0.
Manning connected with Cruz late in the first to give New York a 14-0 lead. Cruz caught a short pass at the Giants 34, but broke Kurt Coleman's tackle and sprinted down the sideline. Cruz again got away from Coleman, when he collided with Asomugha at the Eagles 46, and the second-year pro cruised into the end zone for his first career score.
After the Giants turned it over on downs at the Eagles 29, Vick got going. He had completions of 13 and 17 yards on a drive that was finished off by McCoy's nifty 11-yard TD run. McCoy broke a tackle, cut outside and ran into the end zone to get the Eagles within 14-10.

subset: commoncrawl


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Tour Through Russia
Moving on from Vietnam - our destination last week - we travel north to visit the largest country in the world, covering an incredible 11 time zones, where we will enjoy a rich history and a landscape filled with contrast. Visit Russia.
A Beginner's Guide To How To Fall In Love With Lebanon
The Middle East is a region so rich in history and culture to which many travelers from around the world choose to travel, in a quest for an exotic exciting experience that won't be easy to forget. Lebanon, a small Middle Eastern and Mediterranean nation, has an incredibly rich history dating back to thousands of years ago, making it a large open air museum. Despite its relatively small size, it does offer unique diversity, breathtaking natural wonders, and a mix of cultures and customs that isn't found anywhere else in the region. Its capital city Beirut, has been nicknamed the "Paris of the Middle East", and it really does live up to this name.. Lebanon offers you the opportunity to live a memorable experience and to gain a new perspective on this part of the world, and we, your favourite guides, would like to tell you how! After a long visit to numerous cities in Lebanon. I documented the best experiences lived in the country's most captivating spots.
The Wildlife Volunteer Deliberation
Volunteering has become an increasingly popular activity among globetrotters in the past decade. Whether looking to give something back to a good cause or simply having the desire to boost one's resume, there are a wide variety of opportunities available. In this article, Leigh Woods, Project Manager at Youth Time provides insight into the murky world of wildlife volunteering. Through his extensive experience working with animals, he lends advice on how to avoid having your good intentions exploited in this progressively unreliable field.
Brodet, Golubtsy Or Gemista - Are You Familiar With Dishes From Different Cuisines?
We love traveling. It's also a fact with travel becoming easier we go to far away countries and come across people of different cultures. This also throws up opportunities to try out different cuisines and local specialities. It's a good idea to do away with the familiar and the usual fast food, be a little adventuresome and try out the distinctive tasting local fares on the menus.
What All Can You Get Compensated For While Flying
Flying is not only one of the safest ways of traveling, but with the affordable tickets it is also very popular. One of the unpleasant aspects of flying is the possibility of a delay and being stuck at the airport for several hours if not overnight. But! Did you know there are compensations you can receive for this unpleasantness? Check out this article.
Hidden Gems Of The Czech Republic: A Visit To Chlum U Trebone
It was the fatal year of 1914 when Franz Ferdinand d'Este left his summer house in Chlum u Třeboně, and headed with his wife Sophie, to Sarajevo. It also was here, a few days later, their three children learnt they had become orphans. Chlum u Třeboně can offer not just a rich trip into history, located in South Bohemia, near the Austrian border with a flat landscape filled with ponds, it offers a beautiful summer vacation.
Tip For Trip - Visit French Lille
This relatively less known cultural centre and a historical city is just an hour away from Paris, close to the border with Belgium, by the fast train. The ride in the train is an experience in itself. The city which is a part of the Flandres region bears a fair amount of Flemish look, most especially in the architecture in the older part known as Vieux Lille. Since the city is also well known for its education centres and the university, there is a teeming young population which contributes to the throb, energy and the cosmopolitan feel of the city.
The Shadow Capital Of Serbian Culture And Education – Sremski Karlovci
It is time for Serbia again. Spring is coming, and Serbian towns and the Serbian countryside are reviving and awaiting tourists. Spring time in Serbia is perfect for visiting small towns with rich histories and green forests. Spring weather in Serbia is nice – not too warm and perfect for walking, sightseeing, and camping.
Bangkok For Beginners: Few Useful Tips
It is time for the hot and beautiful coast of Thailand, a country with a very long history, a rich culture, amazing beaches, nice people, and great cuisine. Thailand is a parliamentary monarchy with a king as the head of state. It is the only country in Southeast Asia that was never made a colony by a foreign power. Find out here about Bangkok – Thailand's beautiful capital on the coast.
Hidden Winter Treasures Of Central Europe
In the last article, I introduced you to a few of the most outstanding castles in Central Europe. Now I am going to introduce you to the region's most beautiful winter resorts. These resorts are famous for stunning, snowy, mountainous scenery where you can use your time for winter hiking through forests, by lakes, and towards peaks. If you like skiing or snowboarding, there are many additional choices for your winter holiday in Central Europe. There are even some surprises which you will discover as you read.


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Regis College (MA) Men's Lacrosse Team is set to compete in its third year of the New England Collegiate Conference Men's Lacrosse affiliation in 2015. The team will enter its sixth season of varsity play and fourth Continue Reading
Former Brine CEO Sean Fox Joins 3D Lacrosse as Executive Vice President of OperationsLacrosse Playground /
DENVER, COLO. (October 28, 2014) – 3d Lacrosse, the nation's fastest-growing player development, event and club operations Company, announced today that former Brine, Inc. CEO Sean Fox has joined the organization as Continue Reading
WARREN, MICH. – Oct. 14, 2014 – Brine Lacrosse, a leader in quality lacrosse equipment manufacturing since 1950, announced today that it has signed a multi-year deal with US Lacrosse to become an official equipment Continue Reading
BALTIMORE, August 22, 2014 — The US Lacrosse Foundation received a record equipment donation from Brine, Inc. and Warrior Sports, Inc., exceeding $1,000,000 in retail value. The donated equipment will be Continue Reading
TheLocker And Brine Are Selecting One Team To Win A Private Clinic With Team USA Member Rob PannellLacrosse Playground /
Quincy, MA (August 4, 2014) – TheLocker,lacrosse's first social commerce community, and Brine, recognized industry leader and manufacturer in lacrosse, have teamed up with Rob Pannell, attackman for Team USA and the Continue Reading
This Saturday, Duke Men's Lacrosse will be wearing brand new 2015 King V gloves from Brine. The glove has a Blue Altium/Matte White colorway. The equipment piece is a top all-around glove, King V sets the standard Continue Reading
Mine, Mine, Mine, Mine, Mine... Read More...Continue Reading
Wheaton is a DIII team located in Norton, MA. that plays in the NEWMAC league along with Springfield, Babson, etc... They are a young team this year, but have a ton of new talent from around the country. This year's Continue Reading


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Style # 206469
Show off your logo love with this rocker-chic bebe top, featuring flathead spikes and an ultra soft stretch. Try it with a pair of leatherette leggings and a pair of your favorite boots.
- 58% cotton, 38% modal, 4% spandex.
- Center back to hem: 23" (58 cm).
- Hand wash.
- Imported.
- Model is 5'9" and is wearing a US size S.


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HNDS-004 (a)
$ 9.99
Starring: Ria Sakuragi with Airu Oshima
Release Date: September 25, 2012
Due to Japanese pornography laws, this video contains mosaic censoring of male & female genitals.
Catalog No.: HNDS-004
Running time: 200 minutes
Aspect Ratio: 16:9 Widescreen
Region Code: ALL (playable worldwide)
Audio: Japanese: Dolby Digital Stereo
Format: NTSC
Packaging Options:
• Full DVD Package: Sealed DVD with Full Case & Cover
• DVD Disc Only: DVD Disc with Case & Cover Removed (reduces order total due to lighter shipping)


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Whiskey Review: Jim Beam Kentucky Straight Bourbon
Posted by Arctic Wolf on January 15, 2011
Two weeks ago I began a series of reviews based upon a collection of whisk(e)y samples provided from the personal collection of J.L. Wheelock, a member of the Beam Global team here in Alberta. Part of the sample set of whiskies were a selection of Bourbon Whiskeys from the Jim Beam Distillery. I was not given a sample of Jim Beam Kentucky Straight Bourbon as part of this sample group; however, I happened to have a small 375 ml flask of Jim Beam on hand so I thought that I would provide a review of the flagship whiskey of the Jim Beam brand as part of this series of reviews.
The Jim Beam distillery was founded in 1795, and it has been operated as a family run business for seven generations. Currently Jim Beam Straight Kentucky Bourbon is produced at the Clermont Distillery in Frankfort, Kentucky, and (according to the Jim Beam Website) is the best-selling bourbon in the world. The spirit is aged for 4 years in white American oak barrels and bottled at 40 % alcohol by volume.
The bottle I am reviewing is the 375 ml flask style bottle pictured to the left.
Here is an excerpt from my review:
"…The aroma from the glass is one of rough timbers freshly cut. A waft of vanilla rises with the timbers, and deeper down we have some dank corn and oodles of raw honeycomb. Waiting for a minute or so I also catch some toffee aroma building in the glass as well…"
You may read the full review here:
Review: Jim Beam Kentucky Straight Bourbon Whiskey
As well I have included my version of a nice cocktail called The Kentucky Margarita. Please enjoy the review.
Sorry, the comment form is closed at this time.


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It doesn't matter that more than 21 years have passed since someone attacked 71-year-old Helen Stuart in her Russell Avenue home on Newark's east side. The vile things that were done to her still color every part of her son's world.
Originally published November 29th, 2010
NEWARK, Ohio - The envelopes and folders are stuffed with faded newspaper clippings about killings, rapes, burglaries and assaults.
There are stories about drug dealers and small-time criminals, even a random item noting that local kids were arrested for allegedly carrying guns.
It's an odd assortment, Murray Stuart acknowledges, as he swivels in the barber's chair that anchors the eclectic decor on the patio of his rural Licking County home and flips through the stacks.
But once a man has lost what was most precious to him, he has to do something.
"You don't know what to do or where to turn," he said.
So Murray has gathered those clippings for two decades the way others might collect seashells and postage stamps. He clings to the hope that one day he'll read something that will offer a clue to who killed his mother.
It doesn't matter that more than 21 years have passed since someone attacked 71-year-old Helen Stuart in her Russell Avenue home on Newark's east side. The vile things that were done to her still color every part of his world.
"A normal death, I could accept. This? It's still unbelievable," said Murray, a 59-year-old retiree who spent 30 years driving snowplows and fixing streetlights for the city of Newark.
Helen Stuart was an ordained minister who taught Sunday school and prayed for people she passed on the highway who had been stopped by police.
She and her husband raised five boys and taught each one the value of hard work, honesty and respect.
She was a secretary and cleaned offices for extra money. Her late husband spent his career at the local Owens Corning plant.
On Sunday afternoons when her sons were young - Murray is the baby of the bunch - she would pack bologna and bread and throw in a jar of mayonnaise, and they'd all go for a ride in the country and a picnic. They rarely had a specific destination in mind.
Helen was a wanderer. After her kids were grown and her husband had died, she converted a Volkswagen bus into a camper and set out for Florida.
She loved to cook and always had a garden. Her canned beans got the family through every winter, and the neighborhood kids always managed to congregate at the Stuart house just about lunchtime. Her homemade bread pudding was so thick and rich it should have come with a warning label.
"The woman was close to perfect in my eyes," Murray said. "She was honest, cared about people, trusting."
Indeed, Newark Police Sgt. Scott Snow said he fears that Helen was simply an easy target. She was attacked in her home, raped, beaten and choked sometime after 8p.m. on April 20, 1989.
It appears that robbery wasn't the motive: Helen's purse was on her bed, $20 poking out of her wallet and $67.42 more inside. Police found $3,110 inside family Bibles.
The question "Why her?" baffles the sergeant: "She was about as low-risk for a victim as you could possibly get."
When April 20, a Thursday, dawned that year, Helen had a busy day ahead. She was to leave on Sunday to visit an old church friend in Portsmouth and was considering staying as long as a week.
She was still recovering from a heart attack the year before and visited her doctor at 9 that morning. Then she went home and worked in the yard. She hung laundry on the line and spent the afternoon visiting a neighbor.
Her grown son Troy, who lived with her because he had developmental disabilities caused byencephalitis when he was a child, left about 3:30 or 4 p.m. to visit his girlfriend.
Helen called Murray about 6 p.m., and she also spoke with an elderly neighbor around 8.
Exactly what happened next is anyone's guess.
Based on her injuries, "she put up a hell of a fight," Snow said.
There were no signs that anyone had forced his way into Helen's home and, at that time of night, she probably would have locked her doors.
When Troy returned home about 11 p.m., he noticed that a shelf above the couch had been knocked from the wall and a few other things were knocked over. Relatives said his disabilities sometimes kept him from processing things, so he wasn't immediately worried.
He found his mother's glasses in the bathroom and knew she couldn't have gone far because she couldn't see a lick without them. He thought she might have gone to spend the night at Murray's house, as she often had done since her heart attack.
But the next morning, Troy realized that she hadn't left a note for him, which was her practice. He called Murray.
About the time the brothers were calling family members and friends to see what was what, an Ohio Department of Transportation highway crew was sealing cracks along Rt. 16 east of Newark, about 5 miles from Helen's home.
A crew member noticed that a gray 1981 Ford Fairmont had been parked on the berm all morning. He peered in a window and saw Helen's naked body in the back seat.
Authorities explored several theories but quickly zeroed in on a man staying next door to Helen. He had a violent past and a penchant for rape.
Detectives discovered that the man had called off sick that night from his stock clerk's job at the local grocery. He told police he'd been visiting family, but the timeline provided by his relatives never matched up.
He is serving 10 years to life in prison for an unrelated rape and kidnapping. He has refused to answer any more of the authorities' questions, and he declined to be interviewed by The Dispatch.
The case was last reviewed in 1993. Now, Newark police detective Steve Vanoy is picking apart the file to see what DNA evidence exists. He hopes a new $20,000 reward offered by Murray and his brothers through Licking County Crime Stoppers will shake loose information.
Murray Stuart doesn't know if he will ever get answers. But he knows that even after two decades, the grisly events that shattered his family still twist his stomach into knots.
"It just doesn't end. It bothers you all the time," he said.
His 21-year marriage dissolved a few years ago, and the camper he bought to travel the country after retirement has never been moved from the carport.
He stays in touch with his two brothers who live out of state, and he checks on Troy, who is in a nursing home. But mostly he keeps to himself. He reads the papers, clips the stories. He searches for answers.
He gets out of the house a few hours each day seeking something ordinary, something normal.
And he begins almost every day with the same gloomy thought: Today's not going to be perfect. It can't be.


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pitbullmamaliz wrote:Planning on starting a stripper cam to make some money?
Sue wrote:pitbullmamaliz wrote:Planning on starting a stripper cam to make some money?
Nah, she probably wants to keep an eye on Teeny's puppies..
airwalk wrote:So the cat is out of the bag, so to speak.....
SisMorphine wrote:airwalk wrote:So the cat is out of the bag, so to speak.....
That it is. For those who aren't a member of my FB or a million other forums on which it's been known for a while: Teeny is currently 51 days into a purposeful breeding and doing fantastic!
furever_pit wrote:So what was the purpose of this breeding? What would you like to see come out of the litter?
Oh, and I for one love puppy webcams. Gets me in trouble at work tho.
airwalk wrote:I won't go back and post the numerous times Alyssa, that you have pounded on others about breeding untitled dogs because everyone here has already seen them.
SisMorphine wrote:I have changed my stance on breeding within the past year or two, and I have no problem admitting that. As anyone cane see from my posts, the more I learn, the more I change my opinion. I guess that's what you would call "education."
SisMorphine wrote:This litter is a rather important litter for the breed. It is one of the basis litters for a new line. We are expecting some pretty intense working dogs from this litter, high prey drive especially. Both dogs have been tested for protection ability. Not only are both working in personal protection, but Bandit has earned PP awards (no not titles). Teeny has earned her CGC, and is the first Alapaha to be registered with CPE from what I gather. The plan was to have her titled in agility prior to breeding, but she came into heat a month early. I was not going to waste 2 years (as I thought I'd be accepted into school in the meant time . . . obviously no longer an issue) just waiting on a title for a dog that had been tested to have the ability to work. I chose to breed her to one of the top Alapahas out there.
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Once the aid is disbursed into the applicant's university account (no sooner than 10-days prior to the beginning of the term), it will be credited toward any outstanding tuition fees or charges.
If there is any remaining credit balance, a refund check will be issued to the applicant via direct deposit into the applicant's checking or savings account. To complete a Direct Deposit Authorization, the students should log into their myCSUB account, click on Enroll in Direct Deposit, and complete the online form as soon as possible. If you have questions concerning this Authorization, please contact Office of Student Financial Services at (661) 654-3225.
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Hurricane Sandy's impact on the Atlantic Coast of the United States intensified, as it combined with the full moon at high tide. The Hunter's Moon, which is also known as blood moon or sanguine moon, is the name given to October's full moon. It follows the Harvest Moon, which is September's moon. Historically, the brightness of the moon made it ideal for hunters at night in Northern Europe. Native Americans adopted the name, as they hunted game for the winter by its light. (Folks sometimes confuse the Harvest Moon with the Hunter's Moon, because once every 4 years or so the Harvest Moon appears in October instead of September. When that happens, the Hunter's Moon is in November.) Full moons have higher than normal tides which exacerbated the hurricane's destructive force and surging seas.
Moon from Cape May Lighthouse 29th October


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Federal officials said Thursday a fire at the Chinese Consulate in San Francisco was ignited at the front of the building, leading to an arson investigation and calls from the Chinese government for better protection of diplomats in the U.S.
No one was hurt in the Wednesday night blaze that charred the building's doorway, damaged the lobby and burned upward toward the roof.
FBI spokesman Peter Lee said the blaze was caused by an "incendiary device," but didn't specify what it was. No bomb-making materials were found, and there were no traces of an explosion, Lee said. The FBI is leading the investigation.
Consulate workers say surveillance footage showed a person coming out of a van parked outside the compound with two buckets, pouring the contents on the front of the building and setting it on fire. The consulate has a surveillance camera outside the building located in San Francisco's Western Addition district.
"We strongly condemn this despicable act and have already made representations with the U.S. on the attack," said Wang Chuan, a spokesman for the Chinese consulate in San Francisco. "And we hope that the U.S. takes all necessary measures to provide adequate protection to the consular personnel and properties and bring the culprits to justice as soon as possible."
The consulate is awaiting results from the investigation and will not speculate on who is behind the attack, Chuan said. He said they don't yet know how much repairs will cost.
Lee said he did not know whether the consulate had received any threats recently or any demonstrations at the site. Police stepped up their presence in the area around the consulate building on Thursday.
The U.S. State was in immediate contact with Chinese consulate and embassy in Washington after the fire, department spokeswoman Marie Harf said.
Harf said it was too early to judge whether security at the consulate had been adequate.
"We take this incident very seriously, and the Bureau of Diplomatic Security is working with the FBI and local authorities to investigate and apprehend the perpetrators," Harf said. "Department officials are communicating with Chinese officials to provide support and updates on the case."
Police and firefighters arrived at the scene of the fire and crews brought the flames under control within minutes, fire department spokeswoman Mindy Talmadge said.
The fire caused "serious damage to the facilities of the consulate and endangered the safety of the consulate officials and the citizens living nearby," Chuan said.


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RO4929097 And Exemestane in Treating Pre- and Postmenopausal Patients With Advanced or Metastatic Breast Cancer
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01149356
Recruitment Status : Terminated (Manufacturer discontinued drug development.)
First Posted : June 23, 2010
Last Update Posted : May 25, 2015
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Estrogen Receptor Positive HER2/Neu Negative Male Breast Carcinoma Recurrent Breast Carcinoma Stage IIIB Breast Cancer Stage IIIC Breast Cancer Stage IV Breast Cancer
|Drug: Exemestane Drug: Gamma-Secretase Inhibitor RO4929097 Drug: Goserelin Acetate
|Phase 1
I. Determine the maximum-tolerated dose of gamma-secretase inhibitor RO4929097 (RO4929097) in combination with exemestane in pre- and postmenopausal patients with estrogen receptor-positive (ER+) advanced or metastatic breast cancer.
II. Determine the safety and tolerability of this regimen in these patients. III. Determine the progression-free survival of patients treated with exemestane with vs without RO4929097.
I. Determine the overall tumor response rate in patients treated with these regimens.
II. Determine the overall survival of patients treated with these regimens. III. Determine the safety of these regimens in these patients. IV. Determine the quality of life of patients treated with these regimens. V. Identify biomarkers of response to treatment or toxicity.
OUTLINE: This is a multicenter, phase I, dose-escalation study of gamma-secretase inhibitor RO4929097.
Patients receive oral exemestane once daily on days 1-21 and oral gamma-secretase inhibitor RO4929097 once daily on days 1-3, 8-10, and 15-17. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Patients are stratified according to menopausal status (pre- vs postmenopausal) and visceral disease (yes vs no). Patients are randomized to 1 of 2 treatment arms.
ARM I: Patients receive exemestane as in phase I and oral gamma-secretase inhibitor RO4929097 at the MTD determined in phase I. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive exemestane as in arm I. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
In addition to exemestane, pre-menopausal patients receive goserelin subcutaneously every 28 days. Patients may undergo blood and tissue sample collection for correlative studies.
Patients may complete quality-of-life questionnaires at baseline and periodically during study using the Functional Assessment of Cancer Therapy for Breast Cancer (FACT-B).
After completion of study therapy, patients are followed up for 4 weeks and then every 6 months thereafter.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|15 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Phase I Dose Escalation Trial of RO4929097 Administered in Combination With Exemestane in Pre- and Postmenopausal Patients With ER + Metastatic Breast Cancer
|Study Start Date :
|October 2010
|Actual Primary Completion Date :
|December 2012
|Actual Study Completion Date :
|April 2013
Experimental: Arm I
Patients receive oral exemestane once daily on days 1-21 and oral gamma-secretase inhibitor RO4929097 once daily on days 1-3, 8-10, and 15-17. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Drug: Exemestane
Given orally
Other Names:
Drug: Gamma-Secretase Inhibitor RO4929097
Given orally
Other Name: RO4929097
Drug: Goserelin Acetate
Given subcutaneously to premenopausal patients
Other Names:
Active Comparator: Arm II
Patients receive exemestane as in arm I. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Drug: Exemestane
Given orally
Other Names:
Drug: Goserelin Acetate
Given subcutaneously to premenopausal patients
Other Names:
- Incidence of treatment emergent adverse events (TEAEs) based on CTCAE version 3 grade [ Time Frame: Up to 70 days ]Will be summarized by body system, preferred term, verbatim of adverse event, intensity, and relationship to each study drug (BMS-936558 and/or the peptide vaccine).
- Time to relapse [ Time Frame: Up to 2 years ]Time to relapse will be summarized using descriptive statistics.
- Overall survival [ Time Frame: Up to 2 years ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Diagnosis of breast cancer
Locally advanced or metastatic disease for which curative measures are not effective
- Relapsed disease with (or within 6 months of discontinuation of) an adjuvant nonsteroidal aromatase inhibitor or tamoxifen
- Progressive disease during treatment with first- or second-line hormonal therapy that could include a nonsteroidal aromatase inhibitor, tamoxifen, or fulvestrant
Recurrent disease
- No locally recurrent resectable disease
Histologically confirmed estrogen receptor-positive (ER+) by IHC
- Must have ≥ 5% strong staining for ER+ or ≥ 10% weak staining
- Measurable disease defined as ≥ 1 lesion that can be accurately measured in ≥ 1 dimension (longest diameter to be recorded) as ≥ 20 mm by conventional techniques OR as ≥ 10 mm by spiral CT scan
- No HER2/neu-positive disease
- No known brain metastases
- Pre- or postmenopausal status
- ECOG performance status 0-1
- Life expectancy ≥ 6 months
- WBC ≥ 3,500/mm^3
- ANC ≥ 1,500/mm^3
- Platelet count ≥ 100,000/mm^3
- Hemoglobin ≥ 9 g/dL
- Total bilirubin ≤ 2 mg/dL
- AST and ALT ≤ 2.5 times upper limit of normal
- Creatinine normal OR creatinine clearance ≥ 60 mL/min
- Able to swallow and retain oral medication
- Negative pregnancy test
- Not pregnant or nursing
- Fertile patients must use effective contraception during and for ≥ 12 months after completion of study therapy
- More than 5 years since other invasive cancer except basal or squamous cell cancer of the skin or cervical carcinoma in situ
- No history of allergic reactions attributed to compounds of similar chemical or biologic composition to gamma-secretase inhibitor RO4929097 or other agents used in the study
- No history of torsades de pointes
- No malabsorption syndrome or other condition that would interfere with intestinal absorption (e.g., ulcerative colitis)
- Not serologically positive for hepatitis B or C, have a history of liver disease, other forms of hepatitis, or cirrhosis
- No uncontrolled hypocalcemia, hypomagnesemia, hyponatremia, hypophosphatemia, or hypokalemia
No uncontrolled intercurrent illness including, but not limited to, any of the following:
- Ongoing or active infection requiring parenteral antibiotics
- Impairment of lung function (e.g., chronic obstructive pulmonary disease or lung conditions requiring oxygen therapy)
- Symptomatic congestive heart failure (NYHA class III-IV heart disease)
- Unstable angina pectoris, angioplasty, stenting, and or myocardial infarction within the past 6 months
- Uncontrolled hypertension (systolic BP > 180 mm Hg or diastolic BP > 100 mm Hg on 2 consecutive measurements separated by a 1-week period) despite adequate medical support
- Clinically significant cardiac arrhythmia (multifocal premature ventricular contractions, bigeminy, trigeminy, torsades de pointes, ventricular tachycardia that is symptomatic, or requiring treatment)
- A requirement for antiarrthymics or other medications known to prolong QTC
- Uncontrolled diabetes (hyperosmolar state, ketoacidosis, etc.)
- Psychiatric illness and/or social situations that would limit compliance with study requirements
- No baseline QTcF > 450 msec (male) or > 470 msec (female)
- See Disease Characteristics
- Fully recovered from all previous adverse events
- No prior exemestane for metastatic or recurrent breast cancer, or within the past 6 months in the adjuvant setting
- More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin C)
- At least 2 weeks since prior radiotherapy
- At least 2 weeks since prior and no other concurrent investigational agents
- No prior exposure to γ-secretase inhibitors
- No concurrent medications with narrow therapeutic indices that are metabolized by cytochrome P450 (CYP450), including warfarin sodium (Coumadin®)
- No other concurrent CYP3A4 substrates, inducers, or inhibitors
- No concurrent combination antiretroviral therapy for HIV-positive patients
- No other concurrent anticancer agents or therapies, including chemotherapy, radiotherapy, surgery, immunotherapy, hormonal therapy, or biologic therapy
- No concurrent medications or food that may interfere with the metabolism of gamma-secretase inhibitor RO4929097, including ketoconazole and grapefruit juice
- No concurrent antiarrhythmics or other medications known to prolong QTc
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01149356
|United States, Florida
|Moffitt Cancer Center
|Tampa, Florida, United States, 33612
|United States, Georgia
|Emory University/Winship Cancer Institute
|Atlanta, Georgia, United States, 30322
|United States, North Carolina
|University of North Carolina at Chapel Hill
|Chapel Hill, North Carolina, United States, 27599
|United States, Tennessee
|Vanderbilt-Ingram Cancer Center
|Nashville, Tennessee, United States, 37232
|Principal Investigator:
|Julie Means-Powell, MD
|Vanderbilt-Ingram Cancer Center
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT01149356 History of Changes
|Other Study ID Numbers:
NCI-2010-02181 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
8539 ( Other Identifier: Moffitt Cancer Center )
8539 ( Other Identifier: CTEP )
N01CM00100 ( U.S. NIH Grant/Contract )
P30CA076292 ( U.S. NIH Grant/Contract )
|First Posted:
|June 23, 2010 Key Record Dates
|Last Update Posted:
|May 25, 2015
|Last Verified:
|May 2015
Additional relevant MeSH terms:
Breast Neoplasms
Breast Neoplasms, Male
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms by Site
Breast Diseases
Skin Diseases
Antineoplastic Agents
Aromatase Inhibitors
Steroid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Estrogen Antagonists
Hormone Antagonists
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Antineoplastic Agents, Hormonal


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Purple Long Crown Name Plaque
Brighten up your door or wall with this colouful name plaque.
Easy fixing with the double sided sticky pads on the back of the plaque
Add some letters to make your name or a message
Suitable for names of upto 8 letters.
This product is made of MDF.
Product dimensions : Size: 530x170mm
Please add the correct amount of letters required from the drop down box below and be sure to enter the name as required eg"Thomas" in the message box when you exit checkout.
If selecting Pink Fairytale letters or Blue Adventurer Letters only capital letters are available.
If lower case letters are required please select the multi coloured range
Please allow 7 - 10 days for delivery


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Argument is a wonderful thing.
The exchange of competing ideas in a free marketplace of speech is an American treasure that should be held close to all our hearts.
Argument is a wonderful thing.
The exchange of competing ideas in a free marketplace of speech is an American treasure that should be held close to all our hearts.
While argument makes some people nervous or anxious, others find a strange calm from the art of persuasion, or the attempt to persuade.
So often, as an idea is discussed, I will offer a contrary viewpoint to the prevailing opinion just to stir up a good debate.
This is entertaining at home or at work.
Well, I should say it is entertaining to me. I'm not at all sure that my coworkers or the other members of my family enjoy the contrary nature of my personality as much as I do.
From time to time, believe it or not, I have had some negative comments about my argumentative ways. But it has also served me well professionally.
As the editor of the editorial page, I deal with arguments all the time. People have their say back and forth, and I enjoy being part of offering our local communities a high-profile, public space where these debates can take place.
For years, this page has been a place where differing opinions over, say, President Obama could be found competing with one another.
I don't know whether anyone is persuaded by these partisan pieces. I sometimes suspect that most of them are just preaching to the choir. This is particularly true of the more shrill opinion pieces — letters and columns.
Attacking the president for his supposed sins of being a Muslim or being a communist, for instance, is unlikely to sway anyone on the fence.
It is doubly unlikely to convince anyone who is on the other end of the political spectrum.
The same can be said of the liberal screeds that tend to focus on the predictable, partisan attacks on the GOP or Mitt Romney or Gov. Jindal, or whoever.
These competing and equally obnoxious world views are similar in one way: They aren't persuading or convincing anyone or changing any minds.
I was thinking about this earlier this week while discussing political issues with some Facebook friends.
A friend of mine had linked to an opinion piece by syndicated columnist Frank Rich. The column was an indictment of the Republican Party, which, Rich says, is the party of "deniers." These deniers, Rich would have us believe, are the folks who debate global warming, the folks who don't agree with Keynesian economics and the folks who want to fight voter fraud.
Rich carefully chose the word "deniers" to describe those political adversaries with whom he disagrees.
I pointed this out on my friend's Facebook page and suggested that Rich's piece is extreme and rigidly partisan. The response I got proved my point. "How can you even question global warming?" was one of the responses. And they went on from there. One person said I was the equivalent of "slithering scumballs," his words for Republicans.
It should be offensive to anyone who values debate and open exchanges of ideas for Rich to label dissenters from his opinions not as "mistaken" or even "wrong" but as "deniers." In other words, they are lying about matters of fact, not simply expressing differing opinions.
Judging from the responses I evoked from my friend's friends, Rich is not alone.
I should point out that just because this exchange focused on liberal beliefs, the right-wingers are just as intolerant of differing opinions.
How did we get here, where our views are not matters for debate but fodder for personal attacks?
I don't know, but I can't help but think it's a change for the worse.
As our Washington politicians cling ever more fiercely to party over principle, the same thing is happening to the people in our personal lives, at least those with whom we interact on Facebook and other social media.
My questions are these: What do these people fear? Can their ideas and beliefs not stand up to questioning and debate? If they can, stop being so intolerant of dissent.
The shame of it all is that these partisan blowhards are the roughly 10 percent on either end of the political spectrum. Unfortunately, the 80 percent of us who are somewhere in between are stuck without shrill and obedient mouthpieces.
That's not so bad after all. I guess we're more likely to change minds than they are.
Editorial Page Editor Michael Gorman can be reached at 448-7612 or by e-mail at email@example.com.


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Storing the Step Ladder
Yesterday's high kitchen storage post led us to the inevitable: shopping around for step stools. But once you have a step stool for reaching those high cabinets, you probably aren't going to have it out all the time. So, where do you store it in between uses?
These are four ways to store a kitchen step stool that are convenient and keep the stool out of the way when not in use. Plus, a few are so hidden that the owner is probably the only one privy to their whereabouts!
• 1 in Kevin Sharkey's kitchen, a Polder ladder is hidden away in a toe kick drawer.
• 2 This slim step stool has its own concealed cabinet at the end of an island.
• 3 Bar-height seating doubles as a step stool in this oak piece from Artists in Heaven.
• 4 There's always that space between the fridge and the wall, especially if your stool is as slim as this one from Williams Sonoma.
Do you have a step stool in your kitchen? Where do you store it when it's not in use?
Related: Good Product: Folding Step Stool
(Images: Martha Stewart, GardenWeb, Artists in Heaven, Not Martha)


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GIVEAWAY: OluKai Footwear + Bag the Habit13:11
I have an eco-friendly giveaway pack this week thanks to OluKai and Bag the Habit . OluKai Olu "Comfort", Kai "O...
I have an eco-friendly giveaway pack this week thanks to OluKai and Bag the Habit.
OluKai are also committed to leaving the smallest footprint possible on the planet through environmentally conscious manufacturing and actively supporting and working for a clean environment and a better quality of life.
1// OluKai Apo Lima Sandal. Featuring hand-braided hard leather straps, natural rubber heel cups and arch supports, true to OluKai's signature style.
2// Bag the Habit Luxe Tote - in Chrysanthemum. Featuring Padded handles, premium recycled fabric, and a zippered pocket that fits the entire bag inside, turning it into a compact carrying pouch.
To be in the running....
Leave a comment on this post by Sunday Midnight AEST. Open to all readers, international included.
Winner will be drawn using random.org
88 comments
This comment has been removed by the author.ReplyDelete
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♥ sécia
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Tasha xo
tashachawner [at] gmail [dot] com
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Peace and love from Spain!!
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- MariannaWednesday, February 01, 2012
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- Malvina BeatriceWednesday, February 01, 2012
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elegant_storms at yahoo.com
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lakergirl2113 @ yahoo dot com
olukai is amazing. here's my entry!ReplyDelete
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a new spanish blogger,
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- AnonymousThursday, February 02, 2012
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P.S. I love your blog!
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- anabellaWednesday, February 08, 2012
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- AnonymousSunday, February 19, 2012
Love environmental chic! XxReplyDelete


text:
Linked by Thom Holwerda on Fri 15th Feb 2013 08:21 UTC
"Sebastian Holst makes yoga mobile apps with his wife, a yoga instructor. The Mobile Yogi is sold in all the major mobile app stores. But when someone buys his app in the Google Play store, Holst automatically gets something he says he didn't ask for: the buyer's full name, location and email address. He says consumers are not aware that Google Inc. is sharing their personal information with third parties. No other app store transmits users' personal information to third-party developers when they buy apps, he said." Oh Google.
Permalink for comment 552815
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RE[2]: Obviously a bug
by sdeber on Mon 18th Feb 2013 13:34 UTC in reply to "RE: Obviously a bug"


text:
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1. Registration
- Registration for participating in the ECF system in the Bankruptcy Court for the Middle District of North Carolina begins by reading, filling out and submission of the registration form. See Attachment A.
- Upon completing the training required by the court, a properly registered attorney admitted to practice in this court may become a Filing User. A Filing User is defined by the Local Bankruptcy Rules as a person who has been issued a log-in and password by the court, in order to file documents electronically.
- Once registered, a Filing User may withdraw from participation in the system. Upon the receipt by the Clerks Office of a request to withdraw from participation the participant's password will be cancelled
2. Passwords
- A Filing User must protect and secure the password issued by the court. If there is any reason to suspect the password has been compromised in any way, it is the duty and responsibility of the Filing User to immediately notify the court. This should include the resignation or reassignment of the person with authority to use the password. The attorney/participant should change the password immediately.
- It is strongly recommended that each Filing User periodically change his or her password for security reasons


text:
Derbyshire courts, police and solicitors have been looking at details of report recommending magistrates should be allowed to dispense on-the-spot justice inside police stations at peak times.
Policy Exchange said magistrates should sit during evenings and weekends and suggested recruiting 10,000 new magistrates while closing more courts.
The report - entitled Future Courts - comes as Her Majesty's Court and Tribunals Service faces cut its budget by 2016.
It stated there is a two-month delay from the time an offender is charged to sentencing and justice hubs would mean swifter justice for low level crime.
Justice Minister Damian Green said the Government was looking at magistrates' roles and the report had interesting ideas.
The Magistrates Association is concerned having courts in police stations could lead to people believing there is collusion between police and courts.


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- singular noun; singular verb, vice versa
Don't think it is as easy as you can imagine like the following
One person is...
Two persons are...
I am
You are
Try the following. Fill in the blanks (how "be" is changed for the following?):
Either of 2 people __
Either you or I __
Either I or you __
Neither of the children __
Neither parent or children __
Neither parents or child __
Neither parents or children __
Every person __
Every person and association __
A series of three bombs __
A team __
Teams __
More than 1 cat __
More than 2 cats __
Less than 1 cat __
Less than 2 cats __
Many people __
Many a person __
It is just the tip of the iceberg. There are much more difficult situations arising from the rule.
Think twice, what we can get from knowing the "so-called" correct answer.
First you wrote a sentence grammatically correct and no more. You cannot gain anything from communicating better since you get a grammatically correct answer. Whether you fill the right/wrong answer, people will have no difficulty in understanding you (except they feel the sentence is strange).
Second you will get acknowledged that you are an English elite.
Third you may get a good job because you "use English correctly".
How native speakers are confused at it
It is not true that only learners confuse at it, but also native speakers.
Eg: Neither of the children __
The answer from different people:
One English net-teacher in UsingEnglish forum (https://www.usingenglish.com/forum/viewtopic.php?t=7622 ) -- "are" because children means 2 persons
My native English friend in the UK -- If it is writing, the correct answer is "is". Neither is singular! If it is conversation, "are" is ok.
Authoritative source:
1 Longman Dictionary of Contemporary English (1995)
"are" is used in one similar example
2 Collins Cobuild English Usage (1992)
We should use "is". However people sometimes use plural verb "are"
3 The American Heritage Book of English Usage (1996) http://www.bartleby.com/64/C001/038.html
"is" is used in one similar example "Neither of the twins is"
4 The American Heritage Dictionary of the English Language: Fourth Edition (2000) http://www.bartleby.com/61/41/N0054100.html
Quoted: "The traditional rule also holds that neither is grammatically singular: However, it is often used with a plural verb, especially when followed by of and a plural "


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I decided that trying to do our local holiday bazaars this year was just not going to work. Hubby is taking a welding class on alternate Saturdays . . . which just happen to be the Saturdays I was planning to sell at the bazaars. (Also, flu season and snow have hit. Bleh.) So I am trying to stock up my ArtFire shop. Only two new items posted so far, but I'll be taking some more photos today. Come back soon for more updates!
For some reason, I can't get the other new item's picture into this post. Grrr. So go visit ArtFire.com! My shop is Butterscotch_Grove.


text:
Feeling at home while on holiday – a dream that can become a reality with one's own vacation home. Holiday apartments and houses on Germany's islands, along its coastlines and in the Alpine region are high in demand – both with private owners and capital investors.
Engel & Völkers has compiled its market expertise about a total of 22 holiday locations in Germany in the "Market Report for Holiday Properties in Germany 2016". Dr. Maike Brammer, Head of Research at Engel & Völkers, talks in this video interview (in German, English subtitle available) about the findings of the market report.


text:
Approximately 80 percent of cardiovascular disease (CVD), the nation's number one killer, is preventable through adopting healthy habits such as eating right, controlling cholesterol, getting physical activity, and not smoking. Congress can help stem the effects of CVD and make the U.S. a healthier place to live by ensuring that each state has resources to implement tailored programs to help prevent and control this costly, disabling, and deadly disease.
The American Heart Association advocates for federal funding that helps the Centers for Disease Control and Prevention (CDC) sustain efforts to reduce and prevent the prevalence of CVD.
Our federal advocacy priorities are:
- The Prevention and Public Health Fund, the nation's first dedicated funding stream for improving public health. It includes initiatives such as Community Transformation Grants, which awards grants to design and implement community-level programs that prevent chronic diseases, and Million Hearts, a national initiative aimed at preventing one million heart attacks and strokes in five years.
- The CDC Heart Disease and Stroke Prevention Program, which supports initiatives to reduce morbidity and costs associated with cardiovascular disease.
- CDC's WISEWOMAN program, which screens low-income, uninsured women ages 40-64 for heart disease, stroke, and other cardiovascular disease risk.


text:
Not long ago, 2-by-4 walls insulated with R-13 fiberglass were standard in North American homes, even in regions where winter temperatures fall well below freezing. But residential construction has taken tremendous strides forward. Researchers are helping builders understand much more clearly how heat and moisture move through walls, roofs, and floors. Now, there are a variety of options for building more efficient, comfortable, and durable houses. Tougher building codes promoting energy efficiency and a clamor for lower energy costs have helped advance the technologies, too.
This article will explain some wall-building technologies and techniques in a range of high- and low-tech options. These wall systems come with different price tags and require different construction techniques, some more specialized than others. But all of them are aimed at providing better thermal barriers, fewer air leaks, and lower costs for heating and cooling than conventional stick-frame construction.
One caveat: As houses get tighter, whole-house mechanical ventilation gets more important. If you're planning a super-insulated house with very low air leakage, make room in your budget for a heat recovery ventilator or its equivalent.
Advanced framing (aka optimum value engineering) boils down to less wood and more insulation. This method of framing structurally sound houses with less lumber—saving time and materials—grew out of a partnership between the U.S. Department of Housing and Urban Development and the National Association of Home Builders Research Foundation in the 1970s. Walls built with fewer sticks of wood allow more space for insulation and help reduce thermal bridging—the movement of heat through relatively dense framing members.
Advanced framing technique relies on standard building materials and is relatively easy to adopt, yet yields big returns—30% fewer pieces of lumber and 60% more room for insulation compared to conventional 2-by-4 walls on 16-inch centers. Some of advanced framing's major differences over conventional wood-framed construction:
Some builders haven't liked some elements of advanced framing. Two-stud outside corners made hanging drywall seem problematic, although drywall clips proved an easy fix. Eliminating one of the top plates on the wall also required that studs be 1 1/2 inches longer to maintain the same ceiling height.
There also was a perception that a house framed this way wouldn't be strong enough. Builders who learned traditional framing techniques could see the value of using 2-by-6 studs (more room for insulation) but might balk at the 24-inch on-center (o.c.) spacing and fall back on 16-inch o.c. framing.
But once convinced to try, builders could see the improvements in building performance and ease of assembly, as well as lower labor and material costs. The Building Science Corp. estimates that advanced framing saves 13% in space-conditioning costs compared to conventional construction.


text:
This pamphlet promotes the historic March on Washington of August 28, 1963. The pamphlet calls upon Congress to pass civil rights legislation and end the "twin evils of discrimination and economic deprivation" that plague the nation.
Digital Archive brought to you
by JPMorgan Chase & Co.
Enjoying the Digital Archives? Help us maintain and expand the collection. Donate to The King Center


text:
Seibertron.com - The Ultimate Transformers Fansite
Spike wrote:*sigh* Here we go again.
Alright, here is the post, as best as I can tell, that I had here before the forum wipe. (I posted the same basic thing elsewhere.)
I just got my 12" black RC Dalek, and two Cybermen with gun arms! Great stuff! The RC Dalek is a bit slow, but what detail! His middle section even moves. I like that his head & eyestalk turn & bob respectively... sometimes you can get him to stop with his eye glowing right at you, it's creepy! I love that the eye stays lit when he's turned on to the regular RC mode. And that the demo mode can also be selected, so you can show him off to friends without setting him on the floor. Now I have to get a 12" 10th Doctor figure to fight him!
Alright, picture time! And a few movies for fun
• Cybermen vs the Doctor, Rose, K-9, and the Werewolf
• Dalek Sec running around my room
• Dalek Sec exterminates the other figures! He's a giant!
This is Sec, looking right at the camera. Those LEDs are very bright!
Spike wrote:A $6 Disney Fairies Tinker Bell figure. Yeah. Did I ever mention that, besides Star Wars, Transformers, Spider-Man, and other figures, that I also like Tinker Bell?
Wheeljack35 wrote:Spike wrote:A $6 Disney Fairies Tinker Bell figure. Yeah. Did I ever mention that, besides Star Wars, Transformers, Spider-Man, and other figures, that I also like Tinker Bell?
Wigglez wrote:Just remember. The sword is an extension of your arm. Use it as if you're going to karate chop someone with your really long sharp ass hand.
Return to Non-Transformers Toy Discussion
Registered users: Bing [Bot], Clefjs, Exabot [Bot], FireRoad, Google [Bot], Google Adsense [Bot], Majestic-12 [Bot], MarkNL, Omegatron., Yahoo [Bot], Yweggo


text:
Whаt саn wе say…so fаr wе investigate wе ѕtill can't givе a resolution tо thе dilemma оf knowing whо iѕ Calvin Johnson girlfriend? Sоmе Brittney McNorton оr thе оthеr girl Shallyn Blanton???? Sоmе folks ѕау it might bе gorgeous blonde, Ines Sainz… But isn't ѕhе married guys? I heard hеr husband iѕ a big producer in Mexico. Sо thiѕ iѕ juѕt nonsense. I аlѕо knew hе iѕ mоrе likеlу tо date brunette chicks ѕо Ines might nоt bе hiѕ type either. Thеrе аrе mаnу pics оf him posing with diffеrеnt chicks, but nаmе less…so thе mаn iѕ clever, yes, hе iѕ avoiding scandal аnd уеt date аll thе women hе likes to! Dо уоu hаvе аnу clue whеrеаѕ whо iѕ thiѕ guy dating to? Iѕ it a blonde, a rеd head, a … [Read more...]
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Calvin Johnson Megatron Girlfriend is Brittney McNorton and Shallyn Blanton is His Baby Mama
May 29, 2014 by Dennis Hernandez Leave a Comment
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