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From Our Editors
Boost your energy at Fitness Farm in Indianapolis. Sign up for one of these classes and burn fat, build muscle and stay lean.
Fitness Farm's patrons can find places to park in the area. If working out is the furthest thing from enjoyable, the experts at Fitness Farm in Indianapolis are here to help, so stop in today.

subset: commoncrawl


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I had a vpn client problem and tried to uninstall, but the uninstall does not finish and I get "failed to remove vpn client" and it wants to reboot. when it reboots it goes to setup and says that their is a previous version that needs to be uninstalled before this version can be installed...it tries to uninstall...and goes back to failed to uninstall...then you have ot reboot and so on...anyone havbe any ideas on how to get hte client reinstalled? removed?
Registry Hacks For Removal Of Cisco VPN Client Software
1) Start, Run
2) Regedit
3) HKey Local Machine
4) Software
5) Cisco Systems
6) VPN Client
7) Delete VPN Client Key
Delete any directory on your hard drive
that the software was in
8) Reboot
9) Install updated Software
10) ?
i'm using 303a, and have tried 303b on this win2k pc also. It still was not uninstalled.


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Yoga Retreats
Second Flat Retreat
A perfect place to relax, to explore the mountain wilderness, to practice yoga while experiencing the original world of remote Australia. This unique 2 night experience will include morning and evening yoga sessions, exquisite meals and luxury accommodation on the banks of the Murrumbidgee River, where you may observe nature at its best with platypus, birds and an abundance of wildlife.
Bali Retreat
Perched atop the white cliffs of the Bukit peninsula on Bali's southernmost tip, tap into some self care and self love and leave feeling deeply nourished in every possible way. Spend your week rejuvenating with daily yoga and meditation sessions, plus a selection of Bali's best cultural and wellness activities. Treat yourself with pool side lounging, laughing with new friends, deliciously healthy gourmet meals, unlimited hours of pampering spa treatments.
Bingin beach - 2019
Yoga In The Wild
Enjoy the exquisite scenery and fascinating alpine heritage. Explore and discover the beauty and solitude of the rugged and dramatic alpine landscapes that surround you. Yoga and Meditation sessions daily that will energise empower and rejuvenate. Reconnect with the joy that is already present within you, but forgotten during the hustle and bustle of present day living. Let's step into the wild.
Croatia Yoga Cruise
The Croatia Gulet Yoga Retreat in collaboration with Mariner Boating, is a magnificent voyage where you will experience the freedom of practicing Yoga, surrounded by the turquoise waters of the Adriatic Sea. The beautiful coastline with idyllic villages, picturesque coves and ancient civilisation are waiting to be explored. This is an excellent opportunity to experience a taste of traditional Croatia at an unhurried pace aboard a sailing Gulet.


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For every purchase made, AMANDA PEARL donates 10% to K.I.N.D. - Kids in Need of Defense.
Click here to learn more!
Enamel/Pearl Lariat Necklace - Cobalt
Inspired by Calder's brightly colored biomorphic shapes, Chamberlain's wild and expressionistic application of automobile paint, and the heat of Wesselmann's "Sunset Nude with Big Palm Tree", pearls have been sawed in half to share space with a half round of smooth enamel in Cobalt Blue, Emerald Green, or Fire Red. The pairing of glossy color with spare and modern forms adds a poppy and dynamic element to layer in with our core pieces.
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Traditional retail price: $250
- 18k gold plated
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Case study boeing 7e7
On January 15th, 1825, another large mass of earth was detached from the light-house hills, and fell with great force on the beach, extending in breadth above three hundred yards from the cliffs, covering an area of twelve acres, and containing, it was supposed, not less than half a million of cubic yards of earth. But there is no such distinction in the English language, whose adjectives admit of no variety of termination. 52. Does man cross the seas, measure the heavens, construct telescopes, &c. But when he endeavours to act so as to deserve applause, and to make the impartial spectator enter into the principles of his conduct, he feels, that to every body but himself, his own life is a trifle compared with that of his officer, and that when he sacrifices the one to the other, he acts quite properly and agreeably to what would be the natural apprehensions of every impartial bystander. If he gives ten minutes to something that requires but five, he must often neglect a duty, and this constitutes duplication and omission of time, to be remedied by taking the unnecessary five minutes from one task and bestowing it on another. The shallow existing must have been considerable in length, breadth, and depth; for subsequently a heavy sea, produced from a northerly gale, removed several of the piles entirely, and others were forced from a perpendicular to a horizontal position. To make it necessary in all cases to have certificates, so far from being a security against abuse, is more likely to be a cloak for those who may wish to take advantage of the patient's defenceless state; whereas in cases of voluntary seclusion, there can be no risk; for with such honourable confidence, we have at once, the proof and the security that it cannot and will not be abused. Instead of the picture of a house, the figure of a square was employed, with one side incomplete. The Specific Essence, or universal nature that was lodged in each particular class of bodies, was not itself the object of any of our senses, but could be perceived only by the understanding. Symons', which issues in generalities such as that quoted near the beginning of this article. This growing gleefulness seemed to be the outcome of new expansions of the pleasurable consciousness, of a pure "Lebenslust". When a slave was accused of crime the master, indeed, could not refuse to hand him over to the torturer, unless he were willing to pay for him the full _wer-gild_ of a freeman, and if the slave confessed under the torture, the master had no claim for compensation arising either from the punishment or crippling of his bondman.[1458] When, however, the slave could not be forced to confess and was acquitted, the owner had a claim for damages, though no compensation was made to the unfortunate sufferer himself. In addition to the Manuscripts, we have the mural paintings and inscriptions found at Palenque, Copan, Chichen Itza, and various ruined cities within the boundaries of the Maya-speaking races. It was an exceptional movement, however, without results beyond their own narrow boundaries. LAUGHTER OF THE INDIVIDUAL: HUMOUR. But it should be remembered, that to make a thing of one kind resemble another thing of a very different kind, is the very circumstance which, in all the Imitative Arts, constitutes the merits of imitation; and that to shape, and as it were to bend, the measure and the melody of Music, so as to imitate the tone and the language of counsel and conversation, the accent and the style of emotion and passion, is to make a thing of one kind resemble another thing of a very different kind. The idea, in short, which those authors were groping about, but which they were never able to unfold distinctly, was that indirect sympathy which we feel with the gratitude or resentment of those who received the benefit or suffered the damage resulting from such opposite characters: and it was this which they were indistinctly pointing at, when they said, that it was not the thought of what we had gained or suffered which prompted our applause or indignation, but the conception or imagination of what we might gain or suffer if we were to act in society with such associates. The learned and eloquent Dunning, afterwards Lord Ashburton, one of the leaders of opposition, defended the ancient custom in the strongest terms. In Friezland and Zealand, there are more than three hundred villages overwhelmed, and their ruins continue still visible on a clear day. The observations of the same astronomer discovered to him, though not so evidently, that the same things were true of all the other Planets; that their orbits were elliptical, and that their motions were swiftest when nearest the Sun, and slowest when furthest from him. This kind of reasoning, which in case study boeing 7e7 itself is all along founded on a mere play of words, could not have gained the assent of thinking men but for the force with which the idea of self habitually clings to the mind of every man, binding it as with a spell, deadening it's discriminating powers, and spreading the confused associations which belong only to past and present impressions over the whole of our imaginary existence. We stock every bit of good, informative publicity that we can find. Janitors and messengers remained quite outside this arrangement. 3. The sailor, who, as soon as he got ashore, should mend his fire with the plank upon which he had just escaped from a shipwreck, would seem to be guilty of an unnatural action. The different periods of life have, for the same reason, different manners assigned to them. III. If the face puts on an habitual smile in the sunshine of fortune, or if it suddenly lowers in the storms of adversity, do not trust too implicitly to appearances; the man is the same at bottom. It was in vain that Copernicus pretended, that, notwithstanding the prejudices of sense, this circular motion might be as natural to the Planets, as it is to a stone to fall to the ground. A record, we observe, which is also an interpretation, a translation; for it must itself impose impressions upon us, and these impressions are as much created as transmitted by the criticism. Three critics have done their best by him: the notes of Coleridge exemplify Coleridge's fragmentary and fine perceptions; the essay of Leslie Stephen is a piece of formidable destructive analysis; and the essay of Swinburne is Swinburne's criticism at its best. If the scale broke, the trial was to be repeated.[1059] It will be seen here that lightness was an evidence of innocence, but in Europe the ordeal was reversed in consequence of the belief that sorcerers became lighter than water. But he was, first of all, the most powerful prince in Europe, and consequently held the highest rank among kings; and then says his historian, 'he surpassed all his courtiers in the gracefulness of his shape, and the majestic beauty of his features. We have seen that the objects which excite our laughter are things human, or akin to the human. If now we try to push the psychological inquiry farther, and ask how the mirth of the child develops into that complex sentiment which in these days we call humour, we find ourselves forced to pause. Neither is this notion of the separate existence of Species, distinct both from the mind which conceives them, and from the sensible objects which are made to resemble them, one of those doctrines which Plato would but seldom have occasion to talk of. We may imagine such a system applied to libraries. The relieving smile may come by way of a playful contemplation of ourselves as pitted against our mighty superior, circumstance; for it is possible to find something amusing, as well as irritating, in the ironies of destiny. Locke and different writers have bestowed so much tedious and unprofitable discussion; some maintaining that the mind was like a watch that goes continually, though more slowly and irregularly at one time than another; while the opposite party contended that it often stopped altogether, bringing the example of sound sleep as an argument, and desiring to know what proof we could have of thoughts passing through the mind, of which it was itself perfectly unconscious, and retained not the slightest recollection. In this case we may suppose that the half-developed mild form of fear is each time swiftly dissolved into nothing by a recognition of the unreality of the cause, of the fact that the touches are harmless and come from the good-natured mother or nurse by way of play. In pastoral countries, and in all countries where the authority of law is not alone sufficient to give perfect security to every member of the state, all the different branches of the same family commonly choose to live in the neighbourhood of one another. Once when we had substituted Leroux's 'Mystery of the yellow room' the station man ordered a copy of that book for himself, and finding it interesting read all the Leroux books in the library. The man who has little resentment for the injuries which are done to himself, must always have less for those which are done to other people, and be less disposed either to protect or to avenge them. The trouble is not generally that the books are bad, but that they might easily be better, and by "better" it must be borne in mind that I mean more closely adapted to the legitimate needs of the community. Having thus determined the village, the same plan is adopted with respect to each family in it, and when the family is identified, the individual is discovered in the same manner. But at the time he sent me that very delightful and spirited publication, my little bark was seen 'hulling on the flood' in a kind of dubious twilight, and it was case study boeing 7e7 not known whether I might not prove a vessel of gallant trim. I freely own to the Reader, that I know no other Tongue besides my Native, except_ French, _in which I am but very moderately skill'd. He said, 'I myself lodge in a first floor, where there are young ladies in the house: they sometimes have company, and if I am out, they ask me to lend them the use of my apartment, which I readily do out of politeness, or if it is an agreeable party, I perhaps join them. The authority of one head may be absolutely extinguished in the field where conflict exists. Let us analyze for instance the word, _xeremimboe_, which means "him whom I teach" or "that which I teach." Its theme is the verbal _mboe_, which in the extract I have above made from Montoya is shown to be a synthesis of the three elementary particles _ne_, _mo_, and _e_; _xe_ is the possessive form of the personal pronoun, "my"; it is followed by the participial expression _temi_ or _tembi_, which, according to Montoya, is equivalent to "illud quod facio;" its terminal vowel is syncopated with the relative _y_ or _i_, "him, it"; so the separate parts of the expression are:— _xe_ _tembi_ _y_ _ne_ _mo_ _e_. The absence of the passive in most American tongues is supplied by similar inadequate collocations of words. 'Can the Ethiopian change his skin, or the leopard his spots?' They are become a habit, a second nature to him. Although now resident inland, they remember the manufacture and use of canoes, _amochol_. In several places on this beach, the sand, shingle, &c., do not exceed four feet in depth, and in some instances are still shallower; thus at Cromer, a large body of calcareous deposition exists, and projects above the beach at low water mark; but between that and the cliffs, now temporarily protected by a sea wall, a shallow or cavity of considerable length and depth must have existed: this induced the inhabitants, who had witnessed the good the jetty had effected (previous to the injury Cromer sustained, and alluded to in a former chapter), to insert a groin immediately to the southward, or rather westward, of the town, eighty-four yards in length. I am perfectly convinced that no insane person, should be without medical superintendance, and that to be placed singly in private houses, not medical, I know from experience to be sometimes most fatal and destructive; some few, it is true, are above all praise. The aspect of a moral question is to be judged of very much like the face of a country, by the projecting points, by what is striking and memorable, by that which leaves traces of itself behind, or 'casts its shadow before.' Millions of acres do not make a picture; nor the calculation of all the consequences in the world a sentiment. The infectiousness of an announcement of the playful temper is clearly illustrated here. It mortifies an architect when his plans are either not executed at all, or when they are so far altered as to spoil the effect of the building. But the conclusion I draw is a different one. Fontenelle, in writing the lives and characters of the members of the academy of sciences, a society of mathematicians and natural philosophers, has frequent opportunities of celebrating the amiable simplicity of their manners; a quality which, he observes, was so universal among them as to be characteristical, rather of that whole class of men of letters, than of any individual. The poet's Muse is like a mistress, whom we keep only while she is young and beautiful, _durante bene placito_; the Muse of prose is like a wife, whom we take during life, _for better for worse_. The greatest portrait-painter the world ever saw used to write under his pictures, '_Titianus faciebat_,' signifying that they were imperfect; and in his letter to Charles V. In the year 1836, the humerus bone probably of the Great Mastodon, was found at Bacton, after a very high tide, one side of which, from the appearance it presents, must have reposed upon chalk. Fire is _mide_ because it is kept up with wood. in 1332 gave such a privilege to Dortmund, and so late as 1355 Charles IV. Only in traditions does the "Stone Age" survive among the Delawares. Some exertion of manhood and self-command is even necessary for this sort of restraint; and the impartial spectator may sometimes view it with that sort of cold esteem due to that species of conduct which he considers as a mere matter of vulgar prudence; but never with that affectionate admiration with which he surveys the same passions, when, by the sense of propriety, they are moderated and subdued to what he himself can readily enter into. ] This does not resemble the Ta Ki, as Dr. In the plays of Terence, written for the educated Romans, the figures assume something of respectability. There is no reason for doubting that thousands of remarkable and absolutely authenticated cures have taken place at the healing waters of Lourdes, or that many of the recorded cases of the cure of epileptics, blind, deaf and dumb and sick at the hands of Saints and others are substantially true. THE BOOKS OF CHILAN BALAM.[236] Civilization in ancient America rose to its highest level among the Mayas of Yucatan. I refer to laughter at _the indecent_ or obscene, whether in actual presentation or in suggestion. Believe me, their theories and their mode of enforcing them stand in the way of reform: their philosophy is as little addressed to the head as to the heart—it is fit neither for man nor beast. At what age should Robinson Crusoe be laid aside? But aimlessness–the lack of an aim–the taking out of books to skim or to glance at, or to look at the pictures, with no desire for amusement, or profit, or anything else–that is certainly worthy of condemnation. The sturdy Oxonians gaped at the spectacle from the distant bank, while a deputation of the more prudent monks followed close upon the floating beacon. It clings to the former, and turns away from the latter. Mrs. If we saw ourselves in the light in which others see us, or in which they would see us if they knew all, a reformation would generally be unavoidable. Footnote 47: '_Rosalind._ Time travels in divers paces with divers persons: I'll tell you who time ambles withal, who time trots withal, who time gallops withal, and who he stands still withal. When in this terrible state, she had more power to engage one's commiseration, than any patient I ever had. I remember I had been reading a speech which Mirabeau (the author of the System of Nature) has put into the mouth of a supposed atheist at the Last Judgment; and was afterwards led on by some means or other to consider the question whether it could properly be said to be an act of virtue in any one to sacrifice his own final happiness to that of any other person or number of persons, if it were possible for the one ever to be made the price of the other. Moore was himself invited to assist in the undertaking, but he professed an utter aversion to, and warned Lord Byron against having any concern with, _joint-publications_, as of a very neutralizing and levelling description. Both he and his father, perhaps, are entirely unknown to us, or we happen to be employed about other things, and do not take time to picture out in our imagination the different circumstances of distress which must occur to him. Nevertheless, the drama is perhaps the most permanent, is capable of greater variation and of expressing more varied types of society, than any other. In reading a book which is an old favourite with me (say the first novel I ever read) I not only have the pleasure of imagination and of a critical relish of the work, but the pleasures of memory added to it. Even when the spirit of the age (that is, the progress of intellectual refinement, warring with our natural infirmities) no longer allows us to carry our vindictive and headstrong humours into effect, we try to revive them in description, and keep up the old bugbears, the phantoms of our terror and our hate, in imagination. HOW selfish soever man may be supposed, there are evidently some principles in his nature, which interest him in the case study boeing 7e7 fortune of others, and render their happiness necessary to him, though he derives nothing from it except the pleasure of seeing it. An old crazy hand-organ was playing Robin Adair, a summer-shower dropped manna on my head, and slaked my feverish thirst of happiness. in her strong toil of grace of Shakespeare is such a fusion; the metaphor identifies itself with what suggests it; the resultant is one and is unique— Does the silk worm _expend_ her _yellow labours_?… Though there may, therefore, be no resemblance between visible and tangible {458} objects, there seems to be some affinity or correspondence between them sufficient to make each visible object fitter to represent a certain precise tangible object than any other tangible object. Man without this would not be a rational agent: he would be below the dullest and most stupid brute. It is certain that sometimes the one and sometimes the other may prevail without altering my purpose in the least: I am held to my purpose by the idea (which I cannot get rid of) of what another suffers, and that it is in my power to alleviate his suffering, not that that idea is always the most agreeable contemplation I could have. The sound, or sensation, too undergoes some {446} variation according as the body is placed on the right hand or on the left, before or behind us. Or he is a person of elegant accomplishments, dresses well, and is an ornament to a private circle. There is many an honest Englishman, who, in his private station, would be more seriously disturbed by the loss of a guinea, than by the national loss of Minorca, who yet, had it been in his power to defend that fortress, would have sacrificed his life a thousand times rather than, through his fault, have let it fall into the hands of the enemy. Study case 7e7 boeing.


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AliExpress referral links
kiwijunglist on 08/07/2019 - 07:50
Strip AliExpress referral looks
Wanting to share a product link in AliExpress but I can't use share -> copy to clipboard.
Can u suggest we allow referral links for seasoned posters/users or automatically strip the referral part of the link?
Related Stores
- Moderatorneil on 09/07/2019 - 14:03
What's the issue with just posting a non-referral link? e.g. https://www.aliexpress.com/item/32811423757.html vs. s.click.aliexpress


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Makeup Newton MA, Hair And Makeup Newton MA
Before you arrange your makeup, you most likely have effectively spent a considerable measure on alternate costs like sustenance, the setting and every one of the beautifications.
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A professional makeup artist Newton MA can make a complimenting style separately for each lady of the hour.


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A powerful partner for electrotherapy
The neoserv® is a suction wave therapy unit equipped for use with 2 or 4 suction electrodes, especially prepared for combination with Duodynator. In suction-wave massage therapy an adjustable vacuum – either continuous-type or pulse-type – is generated inside the suction electrodes by an electric pump. In the areas where the suction electrodes are applied, increased hyperaemia incurs. This has the desirable effect that tissue conductivity beneath the electrodes is improved. However, sensitivity to the electric current is clearly masked by the pulsating suction of the electrodes – a fact that makes the device suitable for use also with patients who are extremely sensitive to electric currents.


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The complete set of Glitch emblems reworked into 3D models, based on the original Flash graphics.
Note that these models were designed with SLA / resin printers in mind. For FDM / FFF (eg. RepRap and Makerbot) I would recommend scaling the models up by maybe 200% so the details are printable.


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Heavy rain lash Chandigarh and surrounding areas
More rain has been forecast at many places in the two states till Tuesday.punjab Updated: Aug 20, 2018 15:05 IST
Heavy rain lashed Chandigarh and its surrounding areas on Monday, after which the mercury dropped by a few notches.
A sharp spell of rain brought down the mercury providing relief to the people from sultry weather conditions. Chandigarh's adjoining towns of Mohali in Punjab and Panchkula in Haryana were also lashed by heavy showers.
According to the meteorological department officials, more rain has been forecast at many places in Punjab and Haryana till Tuesday.
First Published: Aug 20, 2018 15:03 IST


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Create the Ultimate Opt-In Offer
Grow your email list and bank account by creating the the ultimate opt-in offer
Growing your email list doesn't need to be difficult. With the right opt-in offer it can be too easy!
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What's Included:
5 Module Course
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Narrow in your ideal customer and discover their pain points
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Take the guess work out of creation with easy to follow methods
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After years of running everything from a handmade baby gift boutique to designing websites I am bringing the tools and resources you need to make it online.


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Please join the Watershed Institute for a day of fun activities and education about water at their annual World Water Day Festival!
Family fun on World Water Day will include many exciting water-related ventures, like hiking to the Stony Brook, exploring macroinvertebrates under microscopes in our lab, learning to cast a fly-fishing rod, and becoming involved in the H2O Olympics alongside many more. Events will be held in both indoor and outdoor locations.
Admission is $5 per person. Designed for all ages. Children under 3 are free.
For more information about the festival, such as other activities and registration, please click here!


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Current Review of Children's Rights in Canada
The current review of progress in how Canada implements the Convention on the Rights of the Child is officially called the 5th-6th review. On this page you will find:
- Links to the official report by the federal and provincial governments;
- General response to the report by the CCRC and links to alternative analyses being done by the CCRC and its members
- Links to previous recommendations and actions promoted by the CCRC to realize children's rights in Canada
- Information about the official process as it moves forward.
Government Report on Children's Rights in Canada
Canada filed its official 5th-6th report today, more than six months late. Les cinquième et sixième rapports.
Annex I is statistical information. Annex 2 is a report on what officials heard. Annex 3 is an executive summary of report from young people. Annexe 1 – Renseignements et données statistiques . Annexe 2 : Ce que nous avons entendu . Annexe-3-Sommaire-exécutif-du-rapport-CDE.
CCRC Overview Analysis of the Government Report
The report provides general statements and names some specific initiatives that relate to the 2012 recommendations. Missing is substantive analysis of outcomes for children. Missing is analysis of serious issues for the realization of children's rights. There are major gaps in the response to previous recommendations. Some responses to previous recommendations are half-answers. A few good provincial initiatives are listed, for example, but there is no reporting on what has been done in all the other provinces. Recommendations for systemic change are ignored, in spite of clear evidence in Canada that the current system is not working. Rulings by the Canadian Human Rights Tribunal since the last review have ordered redress for serious violations of the rights of indigenous children. If the systems to implement, monitor, and report on children's rights in Canada were working as they should under the Convention, this would have been addressed years ago. Canada's report is a missed opportunity to fix a system that is not working well. Using the review to make substantive changes, as well as listing a few specific programs, would benefit all children and make Canada's federalist system of governance work better for our children and the well-being of our nation.
Children in Canada are not well-served by this report. It will be up to civil society organizations to provide a more honest and balanced account of progress on children's rights in Canada.
Canada's 5th/6th report comes on the 30th Anniversary of the Convention on the Rights of the Child. One benefit of the Convention is a holistic approach that puts children at the center. This report fails to do that. Full implementation of children's rights, the CCRC goal, would make Canada work better for children. We can do better in Canada than this report.
The CCRC and its members will now provide alternative analyses to inform public discussion in Canada and review by the UN Committee on the Rights of the Child.
CCRC Fact sheets and Research Documents
During 2019, members of the CCRC and partner organizations will produce easy-to-read fact sheets of themes and important issues in this review. Each fact sheet will be linked to research documents prepared by persons with expertise in that area of children's rights. Sharing knowledge and analysis is the goal of these pages.
If you have information and analysis that relates to children's rights in Canada, the CCRC is interested in hearing from you. To share information you have, or get further information about CCRC plans for the 2018 Review, send a message to firstname.lastname@example.com.
Raising the Bar for Canada's Report
In anticipation of Canada's official report, the CCRC set out reasonable expectations for five central components to make progress in Canada.
2012 Review: Recommendations to Canada, CCRC reports
Check the recommendations Canada received in 2012, 10 Action Steps proposed by the CCRC to implement the recommendations, the CCRC alternative report for the 3th/4th review, and background research reports on our Monitoring Page.
Summary of progress five years after the 3th/4th review
In 2017 the CCRC prepared an overview of progress on the recommendations from the 2012 review, as of November, 2017.
Review Process: Next Steps
Canada's official report, submitted 9 months late, has been posted on the website of the UN Committee on the Rights of the Child. Since it was filed late, there will be delay in finding a time on the Committee's schedule for its official review. The earliest likely time is late 2020 or 2021.
The CCRC will host a webinar on the official process, once a date has been set. We will work with groups to prepare their own submissions or contribute to a CCRC submission, and share information about the various stages of the review process.
In the meantime, the CCRC encourages efforts to raise public awareness in Canada about children's rights and the benefits of implementation for children and for Canada as a country. If you would like more detailed information or discuss how you can contribute and work with others, please send a message to firstname.lastname@example.com.


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Lady Gaga has cancelled her sold-out show in Indonesia after Islamist hard-liners threatened violence, claiming her sexy clothes and provocative dance moves would corrupt the nation's youth.
The controversy was a blow to the predominantly Muslim country's reputation for combining free speech and democracy with a mostly moderate brand of the faith.
News category: News Shorts.


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KARACHI - Prolonged power outages continue across the City during the holy month of Ramazan on rotational basis of 4 hours maximum during the day time and 2 hours during night. The chief minister chaired a meeting the other day at the CM's House regarding loadshedding in Karachi and the problems being created by interruption in the power supply. He observed that the City was facing a general shortage of electricity owing to the energy crisis prevailing across the country. He was of the view that the loadshedding was undermining developmental works in the City. He felt that there was a need for overcoming the problems by enhancing power generation and minimising loadshedding. The government is planning to execute coal-power projects in a timely manner in the areas of Jherruk and Sondha, where there is abundance of coal reserves. Unannounced power cuts have struck the areas of Malir, Landhi, Korangi, Orangi, Defence, Gulshan, Gulistan-i-Jauhar and FB Area. The new KESC management should take measures to minimise the duration of each span of loadshedding and stop unannounced power cuts. Proper publicity through the media about the timings of loadshedding should be ensured so that people could manage their routine activities. Prolonged electricity crisis gripped the City, this summer. With ensuing problems being faced at the Bin Qasim Power Plant as well. During late summer, most of the Bin Qasim power plant units were functioning on gas, making low pressure of gas leading towards shortage of electric supply. Under the Abarraj management, it is hoped that the electric problem that has in recent times intensified will surely come down.
Saadia Qamar
September 24, 2008


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I have been together with my gf for over a year now. We have decided to move in together within a month or 2. We're 22 (me) and 19 (her) years of age.
About a month ago I found out that she has a mutual crush on one of her internet friends. Some guy who lives on the other side of the planet whom she has known for 4 years now. When she was 16 they had this internet romance which lasted for 2 months. It stopped because the guy found another girl. They've never met irl. Apparently this guy has had many gfs and never for longer than a year.
well.. if it's a public blog, it's open for anyone to read right?
or did you perhaps used her password? ;-)
anyway's what's the distance? does he live in another country? if so. It probably won't work out. and.. just talk about it with her. if you say you really feel uncomfterable with the idea of her seeing him. she wouldn't go anyways :D
Man, your gf is kind of crazy. Who meets someone they met on the internet? But, if I were you I wouldn't gve up on her. Explain to her how unstable her internet-bf situation is because she's still young and stupid. And you should let her know how you're feeling and just off-putting her internet-bf-addiction is.
It's kinda public, but it's under a nickname.
He lives on another continent. Practically on the other side.
I should also add that before she came to the conclusion to be just friends with him she was wondering if she should "run away".
LOL. I also met a girl on the net and we chatted for over 9 years and she's living in different country. She had plans to visit me but no money. Just few weeks ago, i felt that it was not worth the effort to keep the relationship cuz she kept bitching about her break up. So I just sent a good bye message and went off.
You have nothing to worry about. When you post stuff on the internet, it's public, everyone can (and maybe will) read it - you have to be aware of that, even if you use a nickname.
If she thinks her blog is "private" or anonymous just because of using a nickname, she's pretty naive.
"Internet crushes" are highly unpredictable. You really ought to talk to her.
I'll wait a bit if she decides to forget about him completely. If not then I'll have to bring this up, at least before we move in together. Another thing I'm afraid of is that she will take it TOO hard, but I can't pretend going on like I don't know anything and she has brought it onto herself.
Nice plan^^ Hope that it will turn out alright in the end.
really? why was it a bad experience? it would be nice to read about others experiences.
I don't want to talk about it right now...hope you can understand.
Things have taken a weird turn. She was sitting next to me when I was checking my e-mail and there was a bit misleading mail from my Japanese friend who doesn't write proper English. The sentence she saw from the message could imply that there is something going on with me and that person. She didn't tell me this, but she wrote about it on another site. Now she is suspecting me of the very same thing. Now she probably knows how I feel. It's kinda funny and yet not so funny LOL
Talk to her about it asap. Don't let her overthink stuff. Communicate, dammit! that's what couples are supposed to do!
if its driving you insane, bring it up, but dont lay down an ultimatum if you have any intention of keeping her. if you try to make it a confrontation it wont work out for you, i promise. you guys are still pretty young, so maybe youre just fooling around and it doesnt matter too much, but if shes the one, you have to trust her. get rid of her when that trust is betrayed, not before.
you're both overly suspicious and it probably won't work. i'd cut it off, but you probably won't take the advice
I think you can make it work, but like >>13 said, talk to her AS SOON AS POSSIBLE. If you don't, she's just gonna worry and worry and lose her confidence in you. Hurry!
Ok, I pushed SEND and I hope all hell doesn't break loose now and things work for the best.
Don't let her delude herself into thinking that she should go visit the guy because of, well, a delusion that you're unfaithful. I somewhat agree with >>15.


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|9mm / 9x19
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200 Round Case - 243 Win 95 Grain Soft Point Federal Fusion Ammo - F243FS1
Estimated Shipping for 2: $16.00
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SKU: F243FS1 - Case
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Learn How to Play the Gong
Learn How to Play the Gong
A Training Course with Mehtab Benton
Saturday July 27 1:00pm - 7:00pm
Sunday July 28 11:00am - 5:00pm
This is a complete course in How to Play the Gong, from the beginning level to intermediate playing techniques. No prior musical or gong experience is required, and the course is suitable for beginners.
In this certified training course, you will learn:
• Techniques for single and combination mallet strikes
• The effects of playing different areas and percussion points of the gong
• How to create a full experience of sound with rhythm, volume, and playing patterns
• How to build playing sequences to create a gong session
• How to select and take care of your gong
• The role of intuition and meditation in gong playing
• The use of the gong in yoga and healing.


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- Showing rooms from hotel
- Panorama Hideaway, Dassia
- Flight found
- Panorama Hideaway, Dassia
- edit
At a Glance
Board basis explained
Board basis explained
...means that included in the price are all main meals, most drinks, which tend to be local varieties available during bar opening hours.
...means that breakfast, lunch and evening meals, are included in the price.
...means that your breakfast and evening meal is included in the price. In some cases you can choose to receive lunch instead of breakfast - the hotel will confirm this upon arrival.
...means that breakfast is included in the price.
...means that no meals or drinks are included in the price, but you will be provided with catering facilities in your accommodation to cook light meals.
...means that no meals or drinks are included in the price.
Special Notice
A new tourist accommodation tax will be implemented in Greece (mainland and Islands). This tax will be for all stays (regardless of booking date) from 1 January 2018. The tax will be per room, per day and is payable directly to the accommodation at check in. This tax is not included in any prices shown on Alpharooms. The cost is in Euros and will be charged thus (and is subject to change)
Properties registered and licensed as Hotels:
1-2 Stars - €0.50
3 Stars - €1.50
4 Stars - €3.00
5 Stars - €4,00
Properties registered as Apartments:
1-2 Keys - €0.25
3 Keys - €0.50
4 Keys - €1.00
Help with hotel, flight or payment?
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Hotel facilities
- Internet access - wireless
- Free WiFi - Public Areas
- Free Wi-Fi
Pool and Wellness
- Swimming Pool - Outdoor
- BBQ facilities
- Library
- Arcade Games
Food & Drink
- Restaurant
- Snack bar/deli
- Breakfast available (Surcharge)
- Bar / Lounge
Services & Shops
- Car rental
- Laundry facilities
- Luggage storage
- Currency exchange
- Tour assistance
General Info
- Check-in time starts 14:00
- Pets accepted
- Check-in time ends 23:30
- Caters to families
- Photocopy machines
- Garden
- Check-out by 10:30
- Wheelchair accessible
- No- smoking property
Room facilities
Rooms & Comfort
- Air conditioning
Attractions Nearby
- Dassia Beach 0.40 miles
- Ipsos Beach 1.30 miles
- Barbati Beach 2.91 miles
- Kapodistrias Museum 4.47 miles
- Aqualand 4.51 miles
- Mount Pantokrator 5.61 miles
- Port of Corfu 5.64 miles
- Ermones Beach 5.79 miles
- Museum of Ceramic Art 5.91 miles
- New Fortress 5.92 miles
- Solomos Museum 6.11 miles
- Saint Spyridon Church 6.12 miles
- Corfu Archaeological Museum 6.13 miles
- Municipal Gallery of Corfu 6.14 miles
- Palace of Saints Michael and George 6.16 miles
- Corfu Public Garden 6.16 miles
- Museum of Asian Art 6.19 miles
- at_a_glance_airport Corfu CFU25m
Resort Info
Dassia, Corfu
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By faith your are healed but by your gratitude you are made whole. Whatever you may be believing for is on the other side of your thankfulness. Today, Terri shares with you the power of your gratitude and how "Thank you" is the keys to the doors you are praying for God to open. Go […]
Are You speaking one thing and expecting something else? We have to speak consistently over the direction we want our lives to go. Today, Terri shares with you the power of positive affirmations and how your words can impact and change your future. Go to https://www.terri.com/declarationslist/ and sign up to receive your affirmations download
Is God dealing with you about something? The key component to your break through is determination. Today, in Terri's 500th podcast episode she shares with you life changing tips on how to wake up with determination. Go to http://store.terri.com/p-64-when-payday-comes-mp3.aspx Use the promo code TERRI500 and get her mp3 teaching of "When Payday Comes"
You are where you are because that's where you chose to be. Your decisions have great power in the outcome of your future. Today, Terri shares with you the enlightening stories of Catherine Lanigan, Zig Ziglar, and more that will empower you to start making firm decisions.


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Snowflakesby mathgrrl Nov 6, 2013
Please Login to Comment
Awesome! Your model has been chosen as one of the best 3D Printed Ornaments this year! Search "Top Free 3d Printed Ornaments Printing Ninja" in google to see (sorry thingiverse bans url addresses)
does this require rafting?
mathgrrl - in reply to marinebiogeek
No raft, and I find it works best without any tape on the build plate. The plate needs to be really level, also, if you want to print a lot of them at once. (Otherwise try printing them one at a time.)


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DD2240 A London-wide approach to welcoming newcomers
Executive summary
The Social Integration team seeks approval to spend up to £95,000 on activities under the Citizenship and Integration Initiative (CII). The activities aim to investigate and better understand how the GLA could develop a city-wide approach to welcoming newcomers and what the central elements of such an approach would be.
Key objectives include:
• Objective 1: Understand and improve opportunities on arrival.
• Objective 2: Publicise, celebrate and connect existing welcome groups.
• Objective 3: Trial a micro-grants programme for welcome.
• Objective 4: Connect welcome initiatives to other work at the GLA.
The Executive Director for Communities and Intelligence approves expenditure of up to £95,000 to support development of a city-wide approach to welcoming newcomers, as part of the Citizenship and Integration Initiative.
Part 1: Non-confidential facts and advice
1.1 In April 2017, the Mayor announced the Citizenship and Integration Initiative (CII) under ADD2056, a pooled fund from independent trusts and foundations which includes secondments from civil society organisations into the GLA. The CII's objectives for the first two years are:
• Civic Engagement: encouraging the take-up of citizenship and involvement in democracy;
• Young Londoners: supporting young Londoners to secure their legal rights to residence; and
• Diversity, social contact and identity: celebrating diversity and building shared identity.
This paper covers work relating to the third of the above objectives and seeks approval of a maximum expenditure of £95,000 from the Communities and Social Policy Unit's 2018/19 budget on work progressing this objective as further set out in paragraph 2.
1.2 Across different GLA departments and among key external stakeholders, there has been growing interest in the question of how new arrivals to London are welcomed and integrated into the life of the city. London, as the fastest growing region in the UK, has a well-established history of welcoming newcomers. The city faces high levels of population churn: in recent years, roughly 200,000 people have moved to London each year from other parts of the UK, and a similar number have arrived from overseas. Since 2015, volunteer-led welcome initiatives have started to help newcomers to become better connected and are providing opportunities for existing residents to play an active role in welcoming new Londoners.
1.3 Across the world, cities with high levels of inward migration - particularly in Europe and the US - are developing approaches to welcoming newcomers to address perceived integration failures and anticipate future challenges. Experience suggests that there is a window of opportunity to engage new arrivals, after which it is increasingly hard to impact on social integration outcomes. London, which draws its population both from across the world and from around the UK, and which experiences high levels of movement within the city, faces a unique context. The UK's exit from the European Union will see that context shift in ways that will affect social integration. Research into London Identities commissioned by the Communities and Social Policy Unit has found that there tends to be low levels of interaction between different social groups in London, and that economic wellbeing strongly impacted on people's perception of belonging and stability in the capital. The research also found signs that there is a distinct London identity that binds residents in the capital. Openness to newcomers and acknowledgement and respect for different groups was a core part of this London identity, and can be built on to increase social integration and civic engagement in London. Initiatives that welcome newcomers are an important part of the social integration picture, as set out in the Mayor's recently-published Social Integration Strategy.
1.4 In light of London's unique context, questions remain regarding the benefits of a city-wide approach to welcoming newcomers, who welcome initiatives would be focused on, and the central elements of an effective approach would be. This project will use mapping, action research and targeted trial interventions to investigate and better understand the benefits to London and to Londoners of activities that welcome newcomers and promote social integration. Evaluation of these investigations and trials will enable us to test current ideas and assumptions around welcome, and will be used as the basis for future decision making.
Time frame
Potential partners
Estimated budget
Objective 1: Understand and improve opportunities on arrival.
Outcome 1: Improved understanding of the opportunities provided by the points at which it is possible to engage new arrivals ('entry points'). Evidence base for how to improve the impact of initiatives targeted at different entry points.
Undertake a mapping of entry points (starting a new school or moving to a new home, as well as specific spaces where the most vulnerable new arrivals are found such as asylum accommodation). Aiming to identify entry points where it is possible to engage with new arrivals, this mapping would involve desk research and conversations with relevant stakeholders, and a review of London Identities research and relevant literature.
April 2018 – July 2018
Business, public sector, and voluntary and community stakeholders (e.g. schools, landlords, and volunteer welcome groups).
GLA staff time
(CII Advisor)
Commission action research focused on institutions that newcomers engage with at these entry points to identify the role they can play in fostering a welcome environment. Research would explore the questions that newcomers ask of institutions when orientating themselves and support institutions to make changes to improve the welcome they provide. This would form the basis of longer-term work with institutions to co-design and test resources that help put newcomers on a pathway to social integration.
September 2018 – March 2019
Business, public sector, and voluntary and community stakeholders (e.g. schools, landlords, and volunteer welcome groups).
Experienced action research providers and evaluators
£25k to commission external research.
Objective 2: Publicise, celebrate and connect existing welcome groups.
Outcome 2: Improved understanding of the impact of strengthened infrastructure on the volume, quality and impact of welcome activities being undertaken in London. A stronger, more developed 'welcome sector'.
Convene and celebrate existing initiatives. Holding a conference to build the consciousness of a 'welcome' sector in London, promote the Mayor's vision for a socially integrated city, and build connections between different organisations supporting newcomers. The event would act a platform to recognise, celebrate and publicise work that is already taking place. Regular follow up events will then be planned for the longer term to assess the impact of these interventions on the availability and awareness of welcome provision in London.
April 2018 - March 2019
Potential date for convening in June. Flexible timings, to accommodate other priority events
Business, public sector, and voluntary and community stakeholders (e.g. volunteer welcome groups).
GLA staff time
(CII Advisor)
£10k for events.
Map pre-existing welcome initiatives across London. To ensure a broad spread of organisations and initiatives take part in this conference, substantial engagement with existing welcome, mentoring and befriending initiatives will be undertaken.
April 2018 - June 2018
Business, public sector, and voluntary and community stakeholders (e.g. volunteer welcome groups).
GLA staff time
(CII Advisor)
Promote volunteering in welcome initiatives through Team London. Team London already advertise community sponsorship volunteering opportunities and could share volunteer vacancies in existing welcome groups.
April 2018 - March 2019
Business, public sector, and voluntary and community stakeholders (e.g. volunteer welcome groups).
Team London
GLA staff time
(CII Advisor)
Objective 3: Trial a micro-grants programme for welcome.
Outcome 3: Improved understanding of the impact of micro-grants on the volume, quality and impact of welcome activities being undertaken in London. A broader offer of welcome initiatives for different population groups or neighbourhoods across London. Increased understanding of the impact of small-scale, volunteer-led welcome initiatives on welcome and social integration in London.
Establish a trial micro-grants scheme to boost the capacity of existing welcome initiatives and strengthen the infrastructure that fosters a welcoming London. Grants of between £1,000 and £5,000 will be made available for voluntary and community initiatives that target newcomers and put them on a path to social integration. Priority will be given to organisations that wish to expand a successful model, connect to other initiatives or target new cohorts of arrivals (e.g. people arriving from other parts of the UK or family reunifications through asylum).
To ensure that micro-grants are targeted most effectively, best practice guidance and some criteria that can be used to assess welcome projects will be developed. Engagement with existing welcome initiatives could be used to strengthen and give credibility to this assessment.
An external evaluation will be built into the micro-grants scheme to ensure that all learning is captured and can be used to encourage the growth of welcome sector infrastructure and to develop the Mayor's approach to welcome in London.
April 2018 - March 2019
Grant scheme to go live by July 2018 (tbc)
Civil society, and voluntary and community welcome initiatives (e.g. volunteer-led welcome groups, mentoring and befriending projects).
£50k in grants available to voluntary and community initiatives
+ £10k for external evaluation.
Involve civil society infrastructure organisations in supporting welcome. In order to ensure the sustainability of this approach, community & voluntary service organisations and volunteer centres will be engaged to support smaller welcome initiatives. These institutions support the disbursement of funds and help provide development support, including training and capacity-building. Team London could also provide specific expertise where needed.
April 2018 - March 2019
Community & Voluntary Service Organisations; Volunteer Centres
GLA staff time
(CII Advisor)
A proportion of the above funding for micro-grants scheme could be allocated for civil society infrastructure organisations.
Objective 4: Connect welcome initiatives to other work at the GLA.
Outcome 3: Improved understanding of welcome and social integration approaches across GLA programmes. Greater public recognition for the Mayor's work on welcome.
Use work on welcome to promote messages that London is open for everyone, for example by working with relevant GLA teams to include welcome section on appropriate pages on london.gov.uk and linking to upcoming work to develop a portal for EEA nationals in London.
April 2018 - March 2019
GLA digital, marketing and communications teams
GLA staff time
(CII Advisor)
As understandings of welcome approaches develop and as decisions are made about whether and how to invest in a city-wide approach to welcome, work with relevant GLA teams to promote the Mayor's approach to welcome through public advocacy. Promote public statements, submissions to relevant inquiries and calls for central government intervention, to enable the Mayor's language around welcome and social integration to be recognised and gain acceptance.
January 2019 - March 2019
GLA stakeholders.
External partners where relevant, such as British Academy, international networks.
GLA staff time
(CII Advisor)
3.1 Under Section 149 of the Equality Act 2010, as a public authority, the Mayor of London must have 'due regard' to the need to (i) eliminate unlawful discrimination, harassment and victimisation; (ii) advance equality of opportunity between people who share a relevant protected characteristic and those who do not; and (iii) foster good relations between people who share a relevant protected characteristic and those who do not. Protected characteristics under section 149 of the Equality Act are age, disability, gender re-assignment, pregnancy and maternity, race, religion or belief, sex, sexual orientation, and marriage or civil partnership status (all except the last being "relevant" protected characteristics).
3.2 Equality, integration and inclusion are the drivers behind this programme. This work is planned to enable all Londoners, regardless of their background, the length of time they have been resident or their protected characteristics, to fully participate in the life of the city. The focus on volunteer-led projects provides an opportunity for new and established citizens alike to be included in local volunteering.
3.3 Any commissioning processes will ask potential partners to demonstrate how their projects are inclusive of a diverse group and actively work to eliminate discrimination on the basis of the nine characteristics protected under the Equality Act 2010. In order to ensure the highest standards of equality, diversity and inclusion are upheld, the GLA will use outreach and engagement approaches to target activities at particular groups that are less able to engage, or face greater barriers to engagement, to enable them to participate, whilst ensuring that activities are open and accessible to all Londoners.
3.4 The guidance and resources will be produced in accordance with best practice for accessible communications and there will be translated outputs. The recruitment of the advisory and steering groups will meet equality, diversity and inclusion standards.
Key risks and issues
Mitigation measures
Current probability (1-4)
Current impact
GLA Lead
Risk that social integration is seen as being only for new arrivals or migrants, rather than how we all live well together.
Clear messaging around the benefits to everyone of London being a welcoming city. Evaluation will track the impacts of welcome work on established volunteers as well as new arrivals
Social Integration team
Small community organisations unable to deliver the projects due to lack of capacity.
As part of mico-grants scheme, capacity building conversations; monitoring meetings and one to one support will be provided for community-based coordinators.
Social Integration team
Pilot projects achieve limited impact due to poor promotion and reach in the welcome sector.
Opportunities will be promoted through the GLA's existing civil society and community networks as well as through a targeted campaign. Mapping will establish relationships with a strong network of stakeholders with whom we will share updates and evaluation findings.
Social Integration team
Commissioned partners fail to deliver resources to expected quality or to time.
Set clear and specific parameters for commission; build in regular milestones to check progress; work with trusted partners where possible.
Social Integration team
Financial mismanagement of any funding provided by the GLA to partners involved in the programmes outlined above.
The GLA will conduct due diligence on all partners, appropriate funding agreements will be in place before funding is given.
Social Integration Team
5.1 Approval is sought for expenditure of up to £95,000 for activities under the Mayor's Citizenship and Integration Initiative.
5.2 The estimated cost will be funded from the 2018-19 Social Integration Programme budget held within the Communities and Social Policy Unit.
6.1 Paragraphs 1 to 2 of this report indicates that the decisions requested of the Director concern the exercise of the GLA's general powers, falling within the GLA's statutory powers to do such things considered to further or which are facilitative of, conductive or incidental to the promotion of economic development and wealth creation, social development or the promotion of the improvement of the environment in Greater London; and in formulating the proposals in respect of which a decision is sought officers have complied with the GLA's related statutory duties to:
• Pay due regard to the principle that there should be equality of opportunity for all people;
• Consider how the proposals will promote the improvement of health of persons, health inequalities between persons and to contribute towards the achievement of sustainable development in the United Kingdom; and
• Consult with appropriate bodies.
6.2 In taking the decisions requested, the Director must have due regard to the Public Sector equality Duty; namely the need to eliminate discrimination, harassment, victimisation and any other conduct prohibited by the Equality Act 2010, and to advance equality of opportunity between persons who share a relevant protected characteristic (race, disability, gender, age, sexual orientation, religion or belief, pregnancy and maternity and gender reassignment) and foster good relations between persons who share a relevant protected characteristic and persons who do not share it (section 149 of the Equality Act 2010). To this end, the Director should have particular regard to Section 3 (above) of this report.
6.3 To the extent that it is proposed that expenditure is incurred on the procurement of works, services or supplies, officers must ensure that the works, services or supplies are procured in accordance with the GLA's Contracts and Funding Code and that appropriate contract documentation is put in place and executed by the successful bidder(s) and the GLA before the commencement of any works, services or supplies.
6.4 Paragraph 2 above indicates that the contribution of up to £50,000 to third sector organisations amounts to the provision of grant funding and not payment for supplies or services. Officers must ensure that the funding is distributed fairly, transparently, in accordance with the GLA's equalities and in a manner which affords value for money in accordance with the GLA's Contracts and Funding Code. Officers must ensure that an appropriate funding agreement is put in place between and executed by the GLA and the grant recipients before any commitment to fund is made.
Map pre-existing welcome initiatives across London.
April - June 2018
Undertake a mapping of entry points.
April - July 2018
Promote volunteering in welcome initiatives.
June 2018 - ongoing
Convene and celebrate existing initiatives.
June 2018 (tbc)
Involve civil society infrastructure in supporting welcome.
June 2018 - ongoing
Establish a trial micro-grants scheme to boost the capacity of existing welcome initiatives and strengthen the infrastructure that fosters a welcoming London.
July - September 2018 (tbc)
Commission action research focused on institutions that newcomers engage with at these entry points to identify the role they can play in fostering a welcome environment
September 2018 - March 2019
Work with relevant GLA teams to include welcome section on appropriate pages on london.gov.uk.
September 2018
Work with relevant GLA teams promote the Mayor's approach to welcome through public advocacy
January 2019
Collate and publish findings from investigations and evaluations to inform future decision making.
February - March 2019


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Uveal melanoma
|Uveal melanoma
|Other names
|Ocular melanoma
|Iris melanoma
|A sensation of flashes or specks of dust (floaters); growing dark spot on the iris; change in the shape of the pupil; poor or blurry vision in one eye; loss of peripheral vision in one eye.
|Retinal detachment;
|Usual onset
|Visual abnormalities
|choroid, iris, and ciliary body
|Diagnostic method
|clinical examination by biomicroscopy and indirect ophthalmoscopy
|Differential diagnosis
|For choroid: choroidal tumors, especially choroidal nevus, metastatic tumors, choroidal hemangioma, and osteoma; hemorrhagic conditions like AMD and hemorrhagic choroidal detachment; retinal tumors such as congenital retinal pigment epithelium hypertrophy and retinal pigment epithelium adenocarcinoma; and inflammatory lesions like posterior scleritis. For iris: iris nevus, iris pigment epithelial cyst, iris stromal cyst, metastatic tumor of the iris, melanocytoma, iris atrophy and Cogan-Reese syndrome. For ciliary body: staphyloma, medulloepithelioma and leiomyoma.
|Reduce UV exposure to the eye.
|Brachytherapy, enucleation, proton beam radiotherapy, transpupillary thermotherapy, photocoagulation, photodynamic therapy, and local resection.
|5 cases per million people per year [1]
Uveal melanoma is a cancer (melanoma) of the eye involving the iris, ciliary body, or choroid (collectively referred to as the uvea). Tumors arise from the pigment cells (melanocytes) that reside within the uvea and give color to the eye. These melanocytes are distinct from the retinal pigment epithelium cells underlying the retina that do not form melanomas. When eye melanoma is spread to distant parts of the body, the five-year survival rate is about 15%.[2]
Uveal melanomas, often referred to by the media and in the general population as ocular melanomas, may arise from any of the three parts of the uvea, and are sometimes referred to by their location, choroidal melanoma, ciliary body melanoma, or iris melanoma. Large tumors often encompass multiple parts of the uvea and can be named accordingly. True iris melanomas, originating from within the iris as opposed to originating elsewhere and invading the iris, are distinct in their etiology and prognosis, such that the other tumors are often referred to collectively as posterior uveal melanomas.
Iris melanoma[edit]
Uveal tumors can originate from melanocytes residing within the iris. Benign melanocytic tumors, such as iris freckles and moles (nevi), are common and pose no health risks, unless they show signs of malignancy, in which case they are classified as iris melanomas. Though derived from uveal melanocytes, iris melanomas share more in common with cutaneous (skin) melanomas in that they frequently harbor BRAF mutations associated with ultraviolet damage.[3][4] Iris melanomas are much less likely to metastasize than other uveal melanomas, and less likely to impair vision if detected and treated early. Approximately 5% of uveal melanomas involve the iris.[5]
Posterior uveal melanoma[edit]
Benign melanocytic tumors of the choroid, such as choroidal freckles and nevi, are very common and pose no health risks, unless they show signs of malignancy, in which case they are considered melanomas.[6][7] Uveal melanoma is distinct from most skin melanomas associated with ultraviolet exposure; however, it shares several similarities with non-sun-exposed melanomas, such as acral melanomas and mucosal melanomas. BRAF mutations are extremely rare in posterior uveal melanomas;[8] instead, uveal melanomas frequently harbor GNAQ/GNA11 mutations, a trait shared with blue nevi, Nevus of Ota, and ocular melanosis.[9][10] As seen in BRAF, mutations in GNAQ/GNA11 are early events in tumorigenesis and are not prognostic for tumor stage or later metastatic spread.[11] In contrast, mutations in the gene BAP1 are strongly linked to metastatic spread and patient survival.[12] Incidence of posterior uveal melanoma is highest among people with light skin and blue eyes. Other risk factors, such as blue light exposure and arc welding, have been put forward, but are still debated in the field. Mobile phone use is not a risk factor for uveal melanoma.[13]
The cause of uveal melanoma is unclear. Uveal nevi are common (5% of Caucasians)[14], but rarely progress to melanoma.
Because there are no lymphatic channels to the uveal tract, metastasis occurs through local extension and/or blood-borne dissemination.[15] The most common site of metastasis for uveal melanoma is the liver;[16] the liver is the first site of metastasis for 80%-90% of ocular melanoma patients.[17] Other common sites of metastasis include the lung, bones, and just beneath the skin (subcutaneous). Approximately 50 percent of patients will develop metastases within 15 years after treatment of the primary tumor, and the liver will be involved 90% of the time.[18] Metastasis can occur more than 10 years after treatment of the primary tumor, and patients should not be considered cured even after a 10-year interval of monitoring.[19] Molecular features of the tumor, including chromosome 3 status, chromosome 6p status, and chromosome 8q status and gene expression profiling (such as the DecisionDx-UM test), can be used to adjust this likelihood of metastasis for an individual patient.
The average survival time after diagnosis of liver metastases depends on the extent of systemic spread. The disease-free interval, the performance status, the liver substitution by metastases and the serum level of lactic dehydrogenase are the most important prognostic factors for metastatic uveal melanoma.[20] There is currently no cure for metastatic uveal melanoma.
The treatment protocol for uveal melanoma has been directed by many clinical studies, the most important being The Collaborative Ocular Melanoma Study (COMS).[21] The treatment varies depending upon many factors, chief among them the size of the tumor and results from testing of biopsied material from the tumor. Primary treatment can involve removal of the affected eye (enucleation); however, this is now reserved for cases of extreme tumor burden or other secondary problems. Advances in radiation therapies have significantly decreased the number of patients treated by enucleation in developed countries. The most common radiation treatment is plaque brachytherapy, in which a small disc-shaped shield (plaque) encasing radioactive seeds (most often iodine-125, though ruthenium-106 and palladium-103 are also used) is attached to the outside surface of the eye, overlying the tumor. The plaque is left in place for a few days and then removed. The risk of metastasis after plaque radiotherapy is the same as that of enucleation, suggesting that micrometastatic spread occurs prior to treatment of the primary tumor. Other modalities of treatment include transpupillary thermotherapy, external beam proton therapy, resection of the tumor, gamma knife stereotactic radiosurgery, or a combination of different modalities. Different surgical resection techniques can include trans-scleral partial choroidectomy and transretinal endoresection.
When eye melanoma is spread to distant parts of the body, the five-year survival rate is about 15%.[2]
Several clinical and pathological prognostic factors have been identified that are associated with higher risk of metastasis of uveal melanomas. These include large tumor size, ciliary body involvement, presence of orange pigment overlying the tumor, and older patient age.[22][23] Likewise several histological and cytological factors are associated with higher risk of metastasis, including presence and extent of cells with epithelioid morphology, presence of looping extracellular matrix patterns, increased infiltration of immune cells,[16], and staining with several immunohistochemical markers.[24]
The most important genetic alteration associated with poor prognosis in uveal melanoma is inactivation of BAP1, which most often occurs through mutation of one allele and subsequent loss of an entire copy of chromosome 3 (monosomy 3) to unmask the mutant copy.[12] Because of this function in inactivation of BAP1, monosomy 3 correlates strongly with metastatic spread[25] Where BAP1 mutation status is not available, gains on chromosomes 6 and 8 can be used to refine the predictive value of the monosomy 3 screen, with gain of 6p indicating a better prognosis and gain of 8q indicating a worse prognosis in disomy 3 tumors.[26] In rare instances, monosomy 3 tumors may duplicate the BAP1-mutant copy of the chromosome to return to a disomic state referred to as isodisomy.[27] Thus, isodisomy 3 is prognostically equivalent to monosomy 3, and both can be detected by tests for chromosome 3 loss of heterozygosity.[28] Monosomy 3, along with other chromosomal gains, losses, amplifications, and LOH, can be detected in fresh or paraffin-embedded samples by virtual karyotyping.
The most accurate prognostic factor is molecular classification by gene expression profiling of uveal melanomas. This analysis has been used to identify two subclasses of uveal melanomas: class 1 tumors that have a very low risk of metastasis, and class 2 tumors that have a very high risk of metastasis.[29][30] Gene expression profiling outperforms all of the above-mentioned factors at predicting metastatic spread of the primary tumor, including monosomy 3.[31][32][33]
Currently, there is no consensus regarding type or frequency of scans following diagnosis and treatment of the primary eye tumor. Of the 50% of patients who develop metastatic disease, more than 90% of patients will develop liver metastases. As such, the majority of surveillance techniques are focused on the liver. These include abdominal magnetic resonance imaging (MRI), abdominal ultrasound and liver function tests. The scientific community is currently working to develop guidelines, but until then, each patient must take into consideration their individual clinical situation and discuss appropriate surveillance with their doctors.[34] Some ophthalmologists have also found promise with the use of intravitreal avastin injections in patients suffering from radiation-induced retinopathy, a side effect of plaque brachytherapy treatment, as well as imaging surveillance with SD-OCT.
Uveal melanomas are the most common primary intraocular tumor in adults.[16] Uveal melanoma is classified as a rare cancer with 5.1 cases per million people per year.[35] The incidence has remained stable for several years.
In 2018, it was reported that two clusters of cases have been identified in Huntersville, NC and Auburn, AL. Cases involved alumni of Auburn University who were acquainted with each other. Health officials investigated and found that the "cluster" is an artifact of social networking.[36][37][38]
Uveal melanoma was first described in the literature in 1809-1812 by two Scottish surgeons, Allan Burns and James Wardrop.[39]
See also[edit]
- ^ Ocular Melanoma, National Organization for Rare Disorders, 2018
- ^ a b Eye Cancer Survival Rates, American Cancer Society, Last Medical Review: December 9, 2014 Last Revised: February 5, 2016
- ^ Henriquez F, Janssen C, Kemp EG, Roberts F (2007). "The T1799A BRAF mutation is present in iris melanoma". Invest Ophthalmol Vis Sci. 48 (11): 4897–900. doi:10.1167/iovs.07-0440. PMID 17962436.
- ^ Hocker T, Tsao H (2007). "Ultraviolet radiation and melanoma: a systematic review and analysis of reported sequence variants". Hum Mutat. 28 (6): 578–88. doi:10.1002/humu.20481. PMID 17295241.
- ^ Damato B; Coupland S (2008). "Ocular melanoma". Melanoma Molecular Map Project. Retrieved 2013-02-02.
- ^ Augsburger JJ (1993). "Is observation really appropriate for small choroidal melanomas". Trans Am Ophthalmol Soc. 91: 147–75. PMC 1298464. PMID 8140689.
- ^ Shields CL, Demirci H, Materin MA, Marr BP, Mashayekhi A, Shields JA (2004). "Clinical factors in the identification of small choroidal melanoma". Can J Ophthalmol. 39 (4): 351–57. doi:10.1016/s0008-4182(04)80005-x. PMID 15327099.
- ^ Malaponte G, Libra M, Gangemi P, Bevelacqua V, Mangano K, D'Amico F, Mazzarino MC, Stivala F, McCubrey JA, Travali S (2006). "Detection of BRAF gene mutation in primary choroidal melanoma tissue". Cancer Biol Ther. 5 (2): 225–27. doi:10.4161/cbt.5.2.2429. PMID 16410717.
- ^ Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM, Simpson EM, Barsh GS, Bastian BC (2009). "Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi". Nature. 457 (7229): 599–602. doi:10.1038/nature07586. PMC 2696133. PMID 19078957.
- ^ Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T, Obenauf AC, Wackernagel W, Green G, Bouvier N, Sozen MM, Baimukanova G, Roy R, Heguy A, Dolgalev I, Khanin R, Busam K, Speicher MR, O'Brien J, Bastian BC (2010). "Mutations in GNA11 in uveal melanoma". N Engl J Med. 363 (23): 2191–99. doi:10.1056/NEJMoa1000584. PMC 3107972. PMID 21083380.
- ^ Onken MD, Worley LA, Long MD, Duan S, Council ML, Bowcock AM, Harbour JW (2008). "Oncogenic mutations in GNAQ occur early in uveal melanoma". Invest Ophthalmol Vis Sci. 49 (12): 5230–34. doi:10.1167/iovs.08-2145. PMC 2634606. PMID 18719078.
- ^ a b Harbour JW, Onken MD, Roberson ED, Duan S, Cao L, Worley LA, Council ML, Matatall KA, Helms C, Bowcock AM (2010). "Frequent mutation of BAP1 in metastasizing uveal melanomas". Science. 330 (6009): 1410–13. doi:10.1126/science.1194472. PMC 3087380. PMID 21051595.
- ^ Stang A, Schmidt-Pokrzywniak A, Lash TL, Lommatzsch PK, Taubert G, Bornfeld N, Jöckel KH (2009). "Mobile phone use and risk of uveal melanoma: results of the risk factors for uveal melanoma case-control study". J Natl Cancer Inst. 101 (2): 120–23. doi:10.1093/jnci/djn441. PMC 2639317. PMID 19141780.
- ^ Chien JL, Sioufi K, Surakiatchanukul T, Shields JA, Shields CL (May 2017). "Choroidal nevus: a review of prevalence, features, genetics, risks, and outcomes". Curr Opin Ophthalmol. 28 (3): 228–37. doi:10.1097/ICU.0000000000000361. PMID 28141766.
- ^ "Classification and Stage Information for Intraocular (Uveal) Melanoma". National Cancer Institute. 1980-01-01. Retrieved 2013-07-04.
- ^ a b c Kumar, Vinay (2009). "Uvea: Neoplasms". Robbins and Cotran Pathologic Basis of Disease, Professional Edition (8th ed.). Philadelphia, PA: Elsevier. ISBN 978-1-4377-0792-2.
- ^ "Prognostic Indicators". Ocular Melanoma Foundation. 2012. Retrieved 2013-02-02.
- ^ Spagnolo, Francesco; Graziano Caltabiano; Paola Queirolo (January 2012). "Uveal melanoma". Cancer Treatment Reviews. 38 (5): 549–53. doi:10.1016/j.ctrv.2012.01.002. Retrieved 24 November 2013.
- ^ Kolandjian, NA; Wei C; Patel SP; Richard JL; Dett T; Papadopoulos NE; Bedikian AY (October 2013). "Delayed systemic recurrence of uveal melanoma". American Journal of Clinical Oncology. 36 (5): 443–49. doi:10.1097/COC.0b013e3182546a6b. PMC 4574291. PMID 22706174.
- ^ Valpione Sara; et al. (Mar 2015). "Development and external validation of a prognostic nomogram for metastatic uveal melanoma". PLOS ONE. 10 (3): e0120181. doi:10.1371/journal.pone.0120181. PMC 4363319. PMID 25780931.
- ^ "The Collaborative Ocular Melanoma Study: An Overview". Medscape. Retrieved 27 December 2016.
- ^ Augsburger JJ, Gamel JW (1990). "Clinical prognostic factors in patients with posterior uveal malignant melanoma". Cancer. 66 (7): 1596–600. doi:10.1002/1097-0142(19901001)66:7<1596::AID-CNCR2820660726>3.0.CO;2-6. PMID 2208011.
- ^ "General Information About Intraocular (Uveal) Melanoma". National Institutes of Health. 1980-01-01. Retrieved 26 November 2013.
- ^ Pardo M, Dwek RA, Zitzmann N (2007). "Proteomics in uveal melanoma research: opportunities and challenges in biomarker discovery". Expert Rev Proteomics. 4 (2): 273–86. doi:10.1586/14789418.104.22.1683. PMID 17425462.
- ^ Prescher G, Bornfeld N, Hirche H, Horsthemke B, Jöckel KH, Becher R (1996). "Prognostic implications of monosomy 3 in uveal melanoma". Lancet. 347 (9010): 1222–25. doi:10.1016/S0140-6736(96)90736-9. PMID 8622452.
- ^ Damato BE, Dopierala J, Klaasen A, van Dijk M, Sibbring J, Coupland S (2009). "Multiplex Ligation-Dependent Probe Amplification of Uveal Melanoma: Correlation with Metastatic Death". Invest Ophthalmol Vis Sci. 50 (7): 3048–55. doi:10.1167/iovs.08-3165. PMID 19182252.
- ^ White VA, McNeil BK, Horsman DE (1998). "Acquired homozygosity (isodisomy) of chromosome 3 in uveal melanoma". Cancer Genet Cytogenet. 102 (1): 40–45. doi:10.1016/S0165-4608(97)00290-2. PMID 9530338.
- ^ Onken MD, Worley LA, Person E, Char DH, Bowcock AM, Harbour JW (2007). "Loss of heterozygosity of chromosome 3 detected with single nucleotide polymorphisms is superior to monosomy 3 for predicting metastasis in uveal melanoma". Clin Cancer Res. 13 (10): 2923–37. doi:10.1158/1078-0432.CCR-06-2383. PMID 17504992.
- ^ Tschentscher F, Hüsing J, Hölter T, Kruse E, Dresen IG, Jöckel KH, Anastassiou G, Schilling H, Bornfeld N, Horsthemke B, Lohmann DR, Zeschnigk M (2003). "Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities". Cancer Res. 63 (10): 2578–84. PMID 12750282.
- ^ Onken MD, Worley LA, Ehlers JP, Harbour JW (2004). "Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death". Cancer Res. 64 (20): 7205–09. doi:10.1158/0008-5472.CAN-04-1750. PMC 5407684. PMID 15492234.
- ^ Petrausch U, Martus P, Tönnies H, Bechrakis NE, Lenze D, Wansel S, Hummel M, Bornfeld N, Thiel E, Foerster MH, Keilholz U (2008). "Significance of gene expression analysis in uveal melanoma in comparison to standard risk factors for risk assessment of subsequent metastases". Eye. 22 (8): 997–1007. doi:10.1038/sj.eye.6702779. PMID 17384575.
- ^ van Gils W, Lodder EM, Mensink HW, Kiliç E, Naus NC, Brüggenwirth HT, van Ijcken W, Paridaens D, Luyten GP, de Klein A (2008). "Gene expression profiling in uveal melanoma: two regions on 3p related to prognosis". Invest Ophthalmol Vis Sci. 49 (10): 4254–62. doi:10.1167/iovs.08-2033. PMID 18552379.
- ^ Worley LA, Onken MD, Person E, Robirds D, Branson J, Char DH, Perry A, Harbour JW (2007). "Transcriptomic versus chromosomal prognostic markers and clinical outcome in uveal melanoma". Clin Cancer Res. 13 (5): 1466–71. doi:10.1158/1078-0432.CCR-06-2401. PMID 17332290.
- ^ "MRF CURE OM". Melanoma Research Foundation. Retrieved 30 March 2012.
- ^ Kaliki S, Shields CL (2017). "Uveal melanoma: relatively rare but deadly cancer". Eye (Lond). 31 (2): 241–57. doi:10.1038/eye.2016.275. PMC 5306463. PMID 27911450.
- ^ https://www.alabamapublichealth.gov/news/2018/10/24.html
- ^ "What is ocular melanoma? Medical mystery shines light on rare eye cancer".
- ^ Rosenberg, Eli (30 April 2018). "A rare eye cancer showed up in three friends. Doctors want to know if the cases are connected". Washington Post.
- ^ Kivelä T (Aug 2017). "The first description of the complete natural history of uveal melanoma by two Scottish surgeons, Allan Burns and James Wardrop". Acta Ophthalmol. 95 (2): 203–214. doi:10.1111/aos.13535. PMID 28834323.
External links[edit]
|External resources
- All NCI-approved clinical trials for uveal melanoma that has spread to the liver
- National Cancer Institute Clinical Trials Search Results
- National Organization for Rare Diseases - Ocular Melanoma
- Cancer Research UK
- National Cancer Institute - Intraocular (Eye) Melanoma—Patient Version
- Ocular Melanoma Foundation
- A Cure In Sight


text:
High Interest From Them Means Low Interest for You
Big Banks Leading the Lending Charge
According to a recent Wall Street Journal article, a survey of loan officers performed by the Federal Reserve "cited more aggressive competition" among lenders.
Why is this good for you? The increased competition among banks to lend money means lower interest rates for loan recipients — for you. If you've been waiting for the right time to get a business loan, there's good news. Your wait is over.
Business loans, referred to as commercial and industrial loans, "were up 4.4% in the fourth quarter and 16% for all of 2012," according to SNL Financial of Charlottesville, Va. The article went on to recognize that there has been, "a renewed willingness by some banks to lend cheaply and on flexible terms."
Here's a tip: If you have a Wells Fargo & Co. bank near you, check out their loan
offers. They are one of the large banks leading the lending charge, having increased their total number of loans by 12% in 2012.
Our very own Kiddie Academy CFO Sue Wise said, "Our franchisees are being offered more loan packages than they have in a long time. The banks are much more willing to lend, and the offers have become more aggressive and favorable for our franchisees."
Why the shift from tight purse strings to competition?
- In 2009, when unemployment was at its most recent high point of 10%, people began putting their money in a safe place: banks.
- Since then, bank deposits have been steadily growing as people have been getting back to work and earning more money, still wanting to keep it safe.
- Banks are now packed with liquid assets and looking to grow, which means making money by loaning money.
It's time for you to take advantage of what the chairman and chief executive of EagleBank called "ridiculously low, low interest rates."
And remember, people looking to start a franchise business have an increased chance of securing a business loan because the banks feel more confident when they're investing in a proven business system.
Please feel free to post your ideas, questions and comments below, or email us at email@example.com