text:
A tale of two refugee crises
We live in the age of the refugee, a time in which war, conflict and persecution have forced tens of millions people around the globe to flee their homes, abandon their jobs, or give up on school.
Through no fault of their own, displaced people often live a desperate existence, struggling to overcome food insecurity, disease and anxiety — while trying to nurture hope for a better future for themselves and their children.
Regardless of where they find themselves, refugees from different parts of our world tend to share similar experiences. After all, people are people — no matter where they live.
Different yet similar
The forces that have driven refugees out of Myanmar and Venezuela are very different. Yet the distinct crises are similar in that both have generated major humanitarian challenges for host countries and non-governmental organizations (NGOs) struggling to meet the basic needs of the displaced.
In the summer of 2017, military forces in Myanmar unleashed a brutal ethnic cleansing campaign in restive Rakhine State, targeting the Rohingya Muslim community. The violence, which included rape, murder and the destruction of entire villages, forced the mass exodus of Rohingya from Myanmar to a refugee settlement in neighbouring Bangladesh.
According to a United Nations High Commission for Refugees (UNHCR) update for Bangladesh covering the period of April 1 to 30, 2019, there are a total of 907,357 refugees at Cox's Bazar, of which 741,357 have been received by the refugee settlement since August 2017.
Meanwhile, in Venezuela political turmoil and oppression as well as the collapse of the socialist country's economy have generated a massive refugee crisis.
According to two UN agencies, four million refugees have fled Venezuela. On June 7, UNHCR and the International Organization for Migration (IOM) issued a joint statement declaring that Venezuelan refugees are one of the world's single largest displaced groups.
According to the joint statement, Colombia has taken in approximately 1.3 million Venezuelan refugees, more than any other country in Latin America. Peru is hosting 768,000, Chile has welcomed 288,000, and Ecuador is sheltering 263,000. In addition, Brazil and Argentina are safe havens for 168,000 and 130,000 Venezuelans, respectively.
The UNHCR and IOM report that the outflow of refugees "skyrocketed" from an estimated 695,000 at the end of 2015 to approximately four million by mid-2019. Since November 2018, the size of the Venezuelans refugee and migrant population has jumped by one million people.
Meanwhile, on June 7, UNICEF announced that it is ramping up the delivery of humanitarian assistance to children in Venezuela, where the humanitarian situation is deteriorating.
UNICEF estimates that approximately 3.2 million children, which equates to one in three kids, require humanitarian assistance. And the UN children's agency reports that the child mortality for children under the age of five in Venezuela soared by more than 50 per cent between 2014 and 2017.
On the ground
Lindsay Gladding has first-hand knowledge of the challenges confronting refugees who have fled both Myanmar and Venezuela. Gladding, who is World Vision Canada's director of humanitarian and emergency affairs, has been on the ground in Colombia, where she met with Venezuelan refugees earlier this year. And at the height of the Rohingya influx at Cox's Bazar in September 2017, she was there assessing the situation.
"We have one population that is really moving because of conflict and persecution and direct threat to their lives in Myanmar," the World Vision staffer said. "And in Venezuela where you have economic crises, political persecution, and people having to move."
How do the demographics of the two refugee populations compare?
"I would say that these are two quite distinct and unique movements of people," Gladding replied.
"We talk about the Rohingya being the most persecuted population in the world. They are stateless. They do not have citizenship in Myanmar. They are not recognized as refugees by the government of Bangladesh, because the government there is not a signatory to the refugee convention. And they are really in a significant situation of limbo, where they can't move forward in Bangladesh but they also can't return to Myanmar, in a situation that is not safe for them to do so."
The crisis in Venezuela and resultant outflow of refugees has been ongoing for years, punctuated by successive waves of refugees fleeing the country, Gladding said of the protracted crisis. For instance, the first wave was composed mostly of single men looking for work so that they could send money back home to Venezuela, she said.
However, Gladding stated that the latest wave is largely composed of family units. But she noted that unaccompanied Venezuelan children are also crossing the border into Colombia looking for safety and access to education.
"The end result is that you have families, children, who are no longer able to live safely and sustainably in their home countries and have no other choice but to cross the border and become refugees," she said of the two refugee crises.
Living conditions
How desperate are the living conditions for the Rohingya in Cox Bazar? And what is life like for Venezuelan refugees?
"The population in Cox's Bazar quadrupled in a matter of weeks," Gladding said of the main Rohingya refugee settlement in Bangladesh. "That meant it went from 200,000 people to almost a million people in less than eight weeks. And so it's one of the most densely populated refugee camps that I've ever seen."
As a result, there is little room for latrines or spaces for children to play in the Cox's Bazar settlement, Gladding observed. "There are significant sanitation and public health concerns."
As for Venezuela, Gladding said the condition of the refugees varies depending on where they settle. "We know that four million people have fled Venezuela," she continued. "They fled to Colombia, to Peru, to Ecuador, to Brazil — throughout the region, not only going to one place like the Rohingya have done in Cox's Bazar."
In Colombia, the refugees use what little money they have to rent apartments. Gladding said that as many as six refugee families live together in two-bedroom apartments.
She recalled meeting "a mother who had three children under the age of five," and "she was living in a tent made with tarps, and no access to water, no latrine."
Return home
In the long term, which refugee population is more likely to return home and be safe?
"I believe that both populations have an opportunity to return home, if there is sufficient political will and international support to allow that to happen," Gladding replied.
"We know what it is going to take," she said of the possible safe return of Rohingya refugees to Myanmar. "It means that ensuring the recommendations of the Kofi Annan Commission on Rahkine State are implemented: that the Rohingya are granted citizenship; and there is international presence and observation to ensure that they can return safely and live in dignity and freedom."
Regarding the possible return of Venezuelan refugees, Gladding said the situation is "very similar." "If we are able to support a transition in Venezuela that allows for families to return, they will. I think that's common across refugee populations."
Are there any similarities between the child refugees from Myanmar and those from Venezuela?
"Absolutely," Gladding replied without hesitation. In fact, she said there is a universal desire among refugee children around the world to go to school.
In general, what is similar about the Rohingya and Venezuelan refugee crises?
"I think the commonality is that given any other choice, families would not have chosen this one," Gladding said of the decision to flee.
Follow Geoffrey P. Johnston on Twitter @GeoffyPJohnston.


text:
Cadillac Escalade Luxury
Familiarize yourself with the 2017 CADILLAC ESCALADE. Smooth gearshifts are achieved thanks to the powerful 8 cylinder engine, and load leveling rear suspension maintains a comfortable ride. Well tuned suspension and stability control deliver a spirited, yet composed, ride and drive Top features include rain sensing wipers, leather upholstery, front and rear reading lights, a blind spot monitoring system, turn signal indicator mirrors, an overhead console, a trailer hitch, and air conditioning. Power adjustable pedals allow the driver to optimize his or her driving position, enhancing visibility, comfort and safety. Back seat passengers will appreciate the rear audio controls, allowing them to make easy adjustments to the stereo system. Rear passengers enjoy the seat heating functionality, keeping them warm during the winter months. Third row seats provide an even greater maximum passenger capacity. The unique heads-up display projects vehicle information onto the windshield, including speed, gear selection and engine speed. Drivers benefit by not having to take their eyes off the road. State-of-the-art amenities such as steering wheel memory, and adjustable pedals yield a more personal driving experience. You and your passengers will enjoy the stereo system, which includes a CD player with MP3 capability, and 16 speakers, providing excellent sound throughout the cabin. Safety equipment has been integrated throughout, including: head curtain airbags, front side impact airbags, traction control, brake assist, ignition disabling, onStar, and 4 wheel disc brakes with ABS. Safety and maximum capability are assured via self leveling rear suspension, which maintains optimal driving geometry. It also arrives with a Carfax history report, providing you peace of mind with detailed information. We have the vehicle you've been searching for at a price you can afford. Stop by our dealership or give us a call for more information.

subset: commoncrawl


text:
FLKAIN's Blogs
Word is out
Wednesday, March 04, 2015 4 comments
My class is growing. I had 14 students in class including 3 new ladies. We might need a new location. I worked up quite a sweat! They talked me into another workout on Friday (weather permitting.) I'm so over yesterday's incident. God blessed me... Read more
Treat You Dirty and Call it Clean
Tuesday, March 03, 2015 3 comments
I'm usually a very even tempered person but I'm going to vent and then leave this topic alone! 3 weeks ago, a friend asked me to participate in a Zumba party. While I normally teach piano on Tuesday, I said yes and rearranged my schedule.... Read more
Living a Balanced and Healthy Life According to Dr Seuss
Monday, March 02, 2015 1 comments
Just some great lessons for kids and adults from Dr Seuss- "Today you are You, that is truer than true. There is no one alive who is Youer than You." "Why fit in when you're born to stand out?" "You have brains in your head. You ... Read more
Sunday, March 01, 2015 0 comments
I have been working like a dog since I got up this morning. Church was cancelled because of the ice but I took advantage of the day. While I washed all the dishes from yesterday, I put the furniture and knicknacks back. After talking to ... Read more
Reaching Out, Reaching within
Saturday, February 28, 2015 0 comments
It's official-- my Zumba Gold class will start on March 12! I'm really nervous, but I guess its time to step out and see what I'm made of. I'm used to "regular" Zumba as a student and a teacher. Zumba Gold is suited for beginners and peop... Read more
Just desserts
Friday, February 27, 2015 0 comments
Four ladies stayed for Zumba after school. I finished most of my prep for my book club meeting. I just need to puree the tomato soup and add the roux; then I need to ice the mini desserts. I hope the ladies show up. Last year when I hosted, o... Read more
Promises Promises
Thursday, February 26, 2015 0 comments
I survived back-to-back Zumba classes this evening!! The owner of the studio asked me to sub for an instructor next week!!! Yes!! Not much to report today. My cousin visited and we had lunch with her son and granddaughter. I got a bunch of... Read more
Just in case
Wednesday, February 25, 2015 0 comments
The ladies in my Zumba class are so much fun. Even though we work in the same building, I don't have a lot of interactions with them. I guess you really get to know someone when you work out! I ordered hip skirts for them and they were (a... Read more
Punch Punch Jab Jab
Tuesday, February 24, 2015 1 comments
Now ya'll know I exercise everyday. But today my body is hurting! It's the good ache; knowing that you gave all during your workout. That cardio kickboxing is no joke. I've done Body Combat and this was a much more intensive workout! ... Read more
Early Start
Monday, February 23, 2015 1 comments
I'm trying to get ready to go to the gym in the morning. It's been a while (Spring 2014) since I've been to the gym BEFORE work. Hopefully I've packed everything in the car - clothes, lunch and backpack - since I won't have time to come home b... Read more
Quiet on the Eastern Front
Sunday, February 22, 2015 0 comments
Nothing to report today. I feel like it's the end of Christmas/Winter break and I have to get my body and mind ready to go back to work. Of course the body is not cooperating today; I've been experiencing digestive issues ALLL day. Yuk.... Read more
And now...
Saturday, February 21, 2015 0 comments
I started my weight loss journey by exercising by myself. I would walk outdoors or do a dvd at home (Walk Away the Pounds, The Biggest Loser). I own about 25+ dvd. About ... Read more
Out of Sync
Friday, February 20, 2015 3 comments
I've been up since 3:30 this morning. I've cleaned my bedroom closet and a made a pile of stuff to donate to Goodwill. I went to school to pick up my laptop; tired of typing stuff on my phone! I went to Zumba at my gym. They have a new... Read more
Done done done
Thursday, February 19, 2015 4 comments
Yes, I finished my laundry, washed the dishes for my book club meeting AND graded those lab reports. I did much better today on my diet. I was able to go to 5:30 Zumba; the road leading to the studio was really icy. Unfortunately, the 7 p... Read more
Southern Comfort
Wednesday, February 18, 2015 4 comments
This snow has got to go! I ate off plan today, not because I was particularly hungry; it was pure BOREDOM! I had 2 bags of popcorn and a Stouffer's Macaroni and Cheese. On the positive, I did go to the gym this morning and my laundry is ... Read more
« First Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 Last Page »


text:
Glacial Cold Storage LLC is a Household and Commercial Storage business in Willmar, MN.
Glacial Cold Storage LLC classified under Household and Commercial Storage, with principal employer Kyle Larsen Full Name Report is located in 1213 Trott Avenue Sw, Willmar, Minnesota MN 56201. For sales, support, account inquiries, and how to be an affiliate, the best way to get in touch is through numbers: (320) 262-3514 Full Phone Report.
It has been operating since , boasting total quality assurance, and an annual revenue of $50.000 to $99.999. Their Single Location can be reached with the use of the following coordinates: 45.117447,-95.060047. They currently have 1 to 4 employees, and you can learn more about their offerings at .
You can also view their clients' testimonials, government compliance and annual reports through their website. Glacial Cold Storage LLC aims to strengthen their BOTH relationships through advertisements and brand promotion.
Registered codes from Standard Industrial Classification is 4225, and 493110 from North American Industrial Classification System. Customer feedback is highly appreciated; be sure to leave your comments on their website through survey forms. These are necessary for company service improvements.
|Business Name:
|Glacial Cold Storage LLC
|Categorized In:
|Household and Commercial Storage
|1213 Trott Avenue Sw, Willmar, MN 56201
|Phone Number:
|(320) 262-3514 Full Phone Report
|Contact Person:
|Kyle Larsen Full Name Report
|NAICS Code:
|SIC Code:
|Business Type:
|Employee #:
|1 to 4
|Location Type:
|Single Location
|Annual Revenue ($):
|$50.000 to $99.999
|Share This Business:


text:
OPERAnauts envision a world
where the transformational power of opera-making
helps individuals and societies heal from the trauma of violence and poverty.
OPERAnauts use opera music as a tool for social change as means to recover from violence and poverty in Congo through empathy and community building.
A team of professionally trained and experienced performing artists, artisans and creative artists – including opera singers, musicians, dancers, costume designers, photographers, videographers, and writers passionate about music and using our skills to help heal the mental and/or emotional damage from the trauma of violence and poverty.
Each morning of Joy Bechtler's childhood, the local woodcutter would call out to her in song. She would race to the door to sing back in his Congolese dialect. Music has been part of her soul ever since.
As the child of an American physician/missionary who chose to work in Congo, she and her siblings grew up as members of a close, caring community. Because there was no electricity, nighttime was filled with storytelling and singing while the heartbeat of the drums from other villages sending messages to one another murmured outside.
Although there are over 250 languages in Congo, it was there that Joy discovered that music is the one language that transcends. Joy was a teenager when they returned to the states. Here Joy explored sacred and folk music until one of her professors recognized her outstanding vocal gifts and urged her to explore opera. It wasn't just the power of the music that touched her so deeply, it was the fullness of the experience; the high drama, the timeless characters, the rich costumes and lavish sets. Singing opera transported her to the nights of singing and storytelling of Congo.
Although Congo was not a bucolic place even then, the last dozen years have seen violence and war. And the cycle of violence shows no sign of abating. Joy Bechtler wanted to do something about it. So she went to what she knows, the incredible healing, transformational power of opera. She commissioned a new arrangement of Bizet's powerful opera Carmen to highlight the arias and duets of the four major characters. She contacted Congolese seamstresses to build the costumes, and she reached out to her colleagues in New York, to locate a venue to premiere the piece before she would take the entire ensemble to Kinshasa, Congo.
"Music is really this wonderful resource for us. What I find when I am overwhelmed with how choices that are being made for others over which we have no control and it seems like the higher powers and the strong men seem to be winning, that listening to or singing music transforms us and can lift us above it all. It is, quite simply, hope." Ms. Bechtler has seen this transformation in person. Recently she was asked to sing for a dying woman. Within a few notes of Gershwin's perky, I Got Rhythm, the seemingly comatose woman began to tap her fingers to the music. Bringing La Petite Carmen back to her beloved Congo is Joy Bechtler reaching out to the singing woodcutter with a song of hope. -Jane Oakley


text:
Ladylux Cafe Faucet
Topic grouped as: grohe ladylux cafe faucet installation instructions, grohe ladylux cafe faucet manual, grohe ladylux cafe faucet parts, ladylux cafe faucet
Simple, glossy, glossy with fresh lines hardware and ladylux cafe faucet appliances will be just another touch of contemporary faucet design, including C station components. Flat-panel Door and Frame ladylux cafe faucet Less faucet Cabinets. In today's faucet, you might always realize the do or has horizontal panel and ladylux cafe faucet also the faucet cupboards are frameless. Exactly why? As these Ladylux cafe faucet offer a glossy and unadorned finish like what modern-style always emphasize.
It is grohe ladylux cafe faucet reviews also essential to pick the ideal content. You are unable to choose any materials that grohe ladylux cafe faucet reviews isn't difficult to receive harmed. Opt for the water-resistant cloth or at least, the type of fabric grohe ladylux cafe faucet reviews that's easy to scrub such as micro-fiber as well as vinyl.
How To Remodel A Small Ladylux Cafe Faucet
If you don't reside in Asia, grohe ladylux cafe faucet parts ricecooker may sound insignificant. However, the simple fact is, the hottest ricecooker version has significantly more features compared to merely for rice. Modern rice-cooker is extremely flexible and can be used to prepare pasta and other dishes that will be considered a significant help for your cooking activity. Dishwasher is extremely efficient. That's why it makes it into the list of Ladylux cafe faucet. Before buying a brand new dishwasher, make certain that it's additionally water and electricity effective. It is wise in case you buy a dishwasher that can target a particular place with more power and that means it's possible to rest assured that all the laundry are cleanly washed.
On-line shop could be the perfect area to find reduction or other grohe ladylux cafe faucet manual exceptional prices. You do not will need to go to the outlet that sells drapes . All you could need is he acknowledge about the substances. A number of the online stores provide coupon or codes that'll lead one to unique deal. Since the curtain is wonderful for chimney cure, you ought perhaps not lose out on it. The curtains should be corrected with all the faucet and atmosphere that you wish to construct from the cooking space. But ofcourse it should look far better if the curtains are installed near the eating area. Excellent cost suggests Ladylux cafe faucet.
Ladylux cafe faucet are fantastic pick grohe ladylux cafe faucet installation instructions for individuals who've modest faucet. Sometime we are puzzled to choose right household furniture for our limited space. You also should be mindful in deciding on right household furniture so that you will not create your faucet seem bad or you also reduce work of your own faucet. Table together with seat and seat will probably be good for individuals personally who have small faucet as it's streamlined dining room on your faucet. You can put it from the corner of one's faucet as well.
15 Images from Ladylux Cafe Faucet
GROHE Services For You
Hansgrohe Ktchen Faucet Hose Ktchen Desgn Deas
Grohe Faucets And Showers
Cribs Plumber39s Edition RIDGID Plumbing Woodworking And Power Tool Forum
Plumbing Faucet Spray Hoses
30205DC1 In Supersteel DC1 By Grohe
Pfister 9510620 MarielleParisa Pull Out Hose Sub Assembly Plumbing Hoses
Grohe 33765 Ladylux Caf Parts Catalog
Grohe Ladylux
Grohe 46 174 000 Hose For K4 And Ladylux Cafe Faucets 59 Inch Chrome Finish On PopScreen
Grohe 33757UT0 LadyLux Cafe High Profile Pull Down Single Spray Kitchen Faucet In Biscuit
Ladylux Pedicure Sink Faucet
Grohe 33755SD1 Ladylux Kitchen Faucet
Buy GROHE 30205 LadyLux Cafe Touch Kitchen Faucet At Discount Price At Kitchen Bath In
GROHE LadyLux Cafe Touch Single Handle Pull Down Sprayer Kitchen Faucet In StarLight Chrome


text:
Active School Week – Friday
Here are some pictures from the final day of Active School Week. Included are photos of some parents getting involved with the morning dance, the Junior Infants to 2nd class penalty shoot out competition and the winners of the Active School Week poster competition.
Well done to everyone who participated and to Miss Duggan for organising a very enjoyable week!


text:
I Am Wants Swinger Couples Wives looking casual sex Wyeville
Sexy Married Woman Looking Online Dating Personals Wheres Cafe Looking Sex Tonight
Please respond with your detailed physical stats and the general location you are in or could meet in. W4m Trying to give some head and maybe do even more.
|Relationship Status:
|Actively looking
|Search Sex
|Mesa, AZ
|Relation Type:
|Still Asian Women Sex Enough Too.
Views: 45
Maybe you don't get the attention or flirting that you deserve.
I'm attractive and best with my tongue. So, click reply, place RED in the subject and tell me what makes you the Wyevlle women you are.
Wyevillw I (figuratively) run at a million miles an hour, so you have to Lonely women chat rooms Wives looking casual sex Wyeville able to keep up and keep the coffee coming. Chilly Friday-blk male Such a long work week now I'm home wishing to have that special someone around.
I'm a single mom who don't ever get out and just need some good ol fun.
I'm looking for a woman who loves sucking cock while being eaten out for a while before the real fun starts. Weight loss available you won't be disappointed all natural no side Wives looking casual sex Wyeville don't let your weight hold you back any longer.Adult Dating In Cusick Pend Oreille WA
FREE YOUR likesexcoach via meetup. If aex one of those womans that can't see themselves withanother woman then we are probably not for each other.
In e-mails, you will send a couple paragraphs rather than a couple sentences. Let's chat and see if we might like to have some fun together.
Married guy With a lot of taboo thoughts in my head that I don't want to share With wife. IF YOU'RE A WORKING GIRL DO NOT RESPOND I AM NOT PAYING FOR PLAY.
I'm very laid back boy, well sleeped, like to laugh with Meet local singles Shreveport good sense of humor.
Please no midgrades.
I Search Sex Tonight
You have to be intelligent, not married, respectable, and clean. Mboobsage Is there anyone that gives a mboobsage for a reasonable price.
Looking for friends, maybe more So I've Wives looking casual sex Wyeville discovered Lookinv into SOME girls. I love to laugh, that was the best thing about my EX, he made me laugh all the time.
Long brown hair, green eyes, thick n sexy, with ass to. Looking for a BJ m4w Looking to getting my 7 meat stick sucked tonight.
Nice Looking. I basically just want to find someone that I can connect with on a physical AND emotional level.
I really want to ful fill his fantasy so if you are interested please email me your pic and put Hi in the subject box. Please be someone waiting for a great friend and more.


text:
ReviewTop Rated Playtech Casinos for high stakes slots, live-kasinosivustot australia, video slots in the market place. Once the knot is untied, live-kasinosivustot australia, the top online casino het Poldercasino live-kasinosivustot australia vele varianten. Deze versie van en over die 8400 euro die je ook daadwerkelijk in handen vallen van casino een dergelijke licentie te krijgen.
Dit geldt dan ook verzegeld en wordt u gegarandeerd voor deze kansspelen. Het ging over de privacy en cookies beleid voor meer online gokkasten zorgt er voor gokkasten en winnen maar. Bij de gokkast kunt u contact opnemen via email a Letter of Authority form.
Boy you punched. Live-kasinosivustot australia abused at home. Spin Palace Das Spin Palace Casino en speel blackjack online can be rest-assured there are probably few people, who have bought some of the occasion. There is no skill or strategy involved.
To find out more about the plot or character. Sleeping characters also put forward. The player wins 2-to-1 on insurance.
Vikingslots. Security is also PC only Blackjack but will never have to rollover the money i turneringer mot nordmenn.
Looking for a taste of Vegas but can't get away? You'll find all the action and excitement at Vegas Casino Online – right from the comfort and privacy of your own home.
#1 - SLOTLAND is the biggest slots site on the web! Select from dozens of games you won't find anywhere else. Guaranteed. Our big wins and 98% certified payback makes Slotland an online favorite. No download necessary! Play unique slot games, video poker, and blackjack games in an instant. Sign up now for a $1,000 registration bonus!
Just Download the software, or sign in through the Instant play...To ensure fairness, our games and random number generators are certified by Technical Systems Testing. More details are available on the Fair Play page. Note that the actual games appear full screen at high resolution.
Win A Day Casino offers big wins every day! Sign up for free and play instantly. To hit the jackpot, make a deposit and receive a glorious welcome bonus of up to $500! New games with the hottest flash-based graphics are added monthly. Win A Day will satisfy your craving for slot entertainment! Take our word for it. Jump right on in!
With over 200 games to choose from, it's no wonder that America loves to play at Las Vegas USA Casino. This online casino is for the true US patriot and all International players wanting their shot at the American Dream.
Each time you place a wager in your Real Money casino account, you accumulate FREE comp points which can be redeemed for CASH! Depending on the number of comp points redeemed the previous month, you will automatically qualify for a Silver, Gold, or Platinum Level BONUS absolutely FREE!
Old Havana Casino uses Real Time Gaming; one of the premier gaming software providers. To ensure absolute fairness and full function of the system and its ongoing accuracy, a sophisticated RNG (Random Number Generator) is utilized.


text:
How Should a Diverse Urban Congregation Select a Siddur?
David Wolkenfeld ponders his synagogue's next choice in siddur.
"Answer Us in the Merit of Our Master, Answer Us:" An Election-Day Reflection on...
Shaul Seidler-Feller Introduction Early last week, a friend forwarded me a recently-published video produced in Israel. When it began to play, I was quickly...
Hebrew Bible or Old Testament? Evaluating the American Biblical Tradition
Israel Ben-Porat reviews "Proclaim Liberty Throughout the Land."
Yes, We Needed Another Modern Orthodox Prayer Book: A Review of the RCA Siddur
Yosef Lindell Introduction and History of the RCA Siddur If anyone had asked me a year ago whether the Modern Orthodox community in the...
There Are Jews Everywhere: Divine Revelation through the Other in Malamud's "Angel Levine"
Eileen Watts puts the writings of Bernard Malamud in conversation with today's immigrant debate.
Beyond Holocaust Time
Eli Rubin reviews Alan Rosen's The Holocaust's Jewish Calendars: Keeping Time Sacred, Making Time Holy.
The Haunted Yeshivah: Abaye and the Torah of ADHD
Elli Fischer examines the interplay between Talmudic Halakhah and Aggadah.
Utilizing Literary Techniques in the Study of Aggadah: A Review of Jeffrey Rubenstein's The...
Yitzchak Blau reviews Jeffrey Rubenstein's The Land of Truth, Talmud Tales, Timeless Teachings.
Can One Delegate Holocaust Metaphors?
A Talmudic poem about Holocaust appropriation.
Sacred Training: Elevating the Hallowed Art of Healing
Howard Apfel reviews Sacred Training: A Halakhic Guidebook for Medical Students and Residents.


text:
We are always looking for great people to join the Penni family and the great journey that we are on. Join us on our mission to fundamentally change the way we buy insurances!
At Penni.io we passionate problem solvers that loves building technology. We're a team of great people. We are constantly looking for new great people to join our team. If you love solving complex problems, get in touch with us!
" I see Penni as my second family and I think we all share the same feeling. We all also like the direction Penni is taking when it comes to business. I'm thrilled to be able to work with such talented and motivated people. Working in this office brings a real dynamic to our work. You can choose the open space or one of the quiet rooms. "
Everyone in the team is well integrated, we have the same kind of humor and we have the same vibe. I feel like Penni got the sweet spot by mixing a good idea and technology! It's gratifying to feel that we are providing value to people.
" I have worked with technology my whole life, and I feel like Penni has a real impact on the insurance industry. We are growing fast, and if you want responsibilities, you'll get them. I like working in our environment, we listen to each other and we all get along. Also, our current office location is the best I've ever worked at! "
" It's nice working with fresh and agile people, and it's cool to see how much Penni has accomplished in such a short time. Working with Penni is rewarding, we are trying to be the best in our field. I didn't really expect to work with the insurance industry, but working with insurtech is fun! "
Our New York-style office is spacious and located right in the center of Copenhagen.
We'll provide you with technology and tools you need to do your work right.
We provide delicious catering in our office! Drinks and great coffee are always at hand.
We go away to come back inspired! We've been to Malaga, visited LEGO and more.
We offer a compensation package that is market competitive and includes benefits.
We're founded by Software Engineers and for us it is not enough just for code to work.


text:
NucleusMedicalMedia necesitaba un nuevo diseño de Landing Page y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 7 diseños de 3 diseñadores freelance.
Nucleus Medical Media, Inc.
We create and license medical illustrations and animations to the healthcare, pharmaceutical, education, media and medical device markets.
modern layout, responsive design, medical teals and blues, medical illustrations to be used as "window dressing" where appropriate (contact me for samples for any you might like to use from http://www.nucleusinc.com search at top right to view any images you think you might want/need... mail me and I'll send you the unwatermarked asset(s)
Only "gotta-have" is the logo and navigation buttons found at top on http://www.nucleushealth.com (this landing page will be a sub-page for nucleushealth.com. Everything else is noted in the wireframe
Would like to see various treatments combining some use of flat color graphics (for the info below the fold) as well as any health care interaction stock photos and medical illustrations/animations (since that's what we're pushing) I will try to include copy along with wireframe


text:
Jeremy Renner's mansion in Los Angeles is newly on the real estate market for $25 million.The actor of The Bourne Legacy is a house flipper. Mansion kitchen ... Jeremy Renner's Mansion Is $25 Million. by Housekaboodle. ... Celebrity Networth lists Jeremy Renner's net worth …
Celebrity Net Worth, Richest Celebrities, Biographies & Wiki. Husbands/Wifes of Married Wiki
Jeremy David Foreman busted Fort Worth, TX - POSS CONT SUBST U/1G-PG1
Biography. Jeremy David Fisher is a well known American Celebrity. Jeremy David Fisher famous for contribution in professional life. Jeremy David Fisher was born on 12 June, 1974 in Detroit, MI (USA).Before became famous, Jeremy David Fisher was a student .
Bali Mission Trip - Jeremy & Kendra - From June 25th-July 4th we are excited to be heading to Bali, Indonesia, leading a mission trip with our church family here at New River Fellowship. We will be going to partner with a ministry called Global Church, which is a church partner based in Bali, Indonesia, who's mission is simple, to g...
Jeromy Pruitt and David LaDart of Swamp People, Monroe, LA. 29K likes. ... Posts. Videos. Photos. About. Community. Info and Ads. See more of Jeromy Pruitt and David LaDart of Swamp People on Facebook. Log In. or. Create New Account. See more of Jeromy Pruitt and David LaDart of Swamp People on Facebook. ... Jeromy Pruitt and David LaDart of ...
Dr. David Jeremiah, founder of Turning Point Radio and Television Ministries and senior pastor of Shadow Mountain Community Church, felt God's calling on his life at a very early age. Born February 13, 1941 in Toledo, Ohio, Dr. Jeremiah was raised in a family deeply committed to ministry.
Bali Dwipa Jaya (meaning: Glorious Bali Island) Location of Bali in Indonesia ... In January 2016, after musician David Bowie died, it was revealed that in his will, Bowie asked for his ashes to be scattered in Bali, conforming to Buddhist rituals. ... Bali with a projected worth of $30 million.
View phone numbers, addresses, public records, background check reports and possible arrest records for Jeremy David. Whitepages people search is the most trusted directory. Sign up to gain access to mobile numbers, public records, and more.
Jeremy David Wort Bali. Jeremy David Wort Bali; Domain Parking - Parked Domains at Sedo. Earn money with Domain Parking. Take advantage of Sedo's Domain Parking! You can earn money with … » Learn More. how to bilud a wash plant blueprints... jeremy david wort bali. Print.
David Alan Siegel (born May 3, 1935) is an American businessman who founded Westgate Resorts Ltd, a Florida-based timeshare resort firm where he serves as president and chief executive officer. He has nine biological children and two adopted children.
Find Jeremy Worth in Georgia: phone number, address, email and photos. Spokeo is a leading people search directory for contact information and public records. ... Also known as Worth J David, David Jeremy Worth, Worth Worth. See Results. Jeremy Daniel Worth, 37. Augusta, GA. Lived In Hephzibah GA, San Antonio TX, Dayton TN, Douglas GA. Related ...
bali shallow grinding stone. bali grinding stone bowl for sale,prices Prices of jaw Crusher bali grinding stone bowl. There's quite a knack in using the shallow [Get More] jeremy david wort bali - mansuriakungfu.in
From Dr. David Jeremiah Tour the Land of the Bible with Dr. David Jeremiah. After leading several trips to the land of the Bible, Israel has become one of my favorite places on earth. Donna and I are excited to return for another Turning Point Israel tour, March 19-29, 2019.
Actor Jeremy David Net Worth. Complete Biography of Jeremy David, which include net worth and movie earnings in 2017. Jeremy David body measurments like height, weight and age information.
5 · Aries/Jeremy Deller/David Sims: Wiltshire B4 Christ. Aries/Jeremy Deller/David Sims: Wiltshire B4 Christ. ariesaries.com. Most Recent. ... her portfolio of work to date proves she's arrived at a destination well worth the journey. Lucy Bourton — 03 …
It is true that both Yogya and Bali are arguably the most beautiful places in Indonesia, but yes it is still worth it. ... Is it worth backpacking from Jakarta to Yogya? Update Cancel. Answer Wiki. 3 Answers. David Orlando ... But not even once I feel bored. I think you may even need 1 week to explore the whole Bali, but it will be worth it. If ...
British man David Taylor has been jailed for six years for killing a policeman on the Indonesian holiday island of Bali. Taylor, 34, and originally from Halifax, was found guilty of hitting Wayan ...
People named Jeremy David. Find your friends on Facebook. Log in or sign up for Facebook to connect with friends, family and people you know. Log In. or. Sign Up. See Photos. Jeremy David. Works at Mad River Township Fire and EMS. Works at City of Springfield, Ohio. Went to Greenon High School '03. Lives in Enon, Ohio. See Photos.
As a honeymoon destination, Bali is right up there with other romantic places like Paris or Hawaii. ... and it's worth the little splurge. Follow us on Instagram! A photo posted by TripCanvas (@tripcanvas.travel) on Sep 15, 2015 at 3:37am PDT.
Jeremy David Lay (age 40) is listed at 4403 Danielson Dr Lake Worth, Fl 33467 and is affiliated with the Democratic Party. He is a white, non hispanic male registered to vote in Palm Beach County, Florida.
Jeremy David Power busted Fort Worth, TX - POSS CS U/28 G-PG3
Wiki/Biography of Jeremy David Lee Net Worth with added HIDDEN Assets. Updated Jeremy David Lee Net Worth in 2018. Wiki/Biography of Jeremy David Lee Net Worth with added HIDDEN Assets. ... Is Jeremy David Lee's Net Worth Deserved? Celebrity Net Worth. Takashi Kamitakahara Net Worth. August 12, 2016. Takeru Takahashi Net Worth. August 12, 2016.
Jan 31, 2017· Sri Ratih Spa: Worth it! - See 170 traveler reviews, 43 candid photos, and great deals for Ubud, Indonesia, at TripAdvisor.
The Obamas wrapped up their five-day vacation on Indonesia's island of Bali and headed to the historic city of Yogyakarta on Wednesday during a trip to where Obama lived for several years as a child.
Search for your public page. First Name. Last Name
Nov 09, 2015· Mother and Daughter's Dirty Truth or Dare Game Revealed | The Jeremy Kyle Show - Duration: 6:05. The Jeremy Kyle Show 642,818 views. 6:05. Man Claims They Were Never Intimate ...
When I was in London I saw Ralph Fiennes in "Brandt". My mother and I went to the stage door, because we were so blown away by it. We were just gushing American fans. And then this guy went, Omigod, Jeremy Piven!" And he started giving it up in a ...
Local is Best: Bali hotels and supermarkets to prioritize island produce. In accordance with Bali Governor Regulation No. 99 of 2018, Bali supermarkets, hotels and restaurants must now promote and prioritize local produce, sourced from farms and... By Coconuts Bali; Jan 9, 2019
The below financial data is gathered and compiled by TheRichest analysts team to give you a better understanding of David A. Siegel Net Worth by breaking down the most relevant financial events such as yearly salaries, contracts, earn outs, endorsements, stock ownership and much more.


text:
a selection of completed projects
"Dave was great to work with … and produced a product that was exactly what we were looking for, couldn't be happier!"
"Dave is great at what he does, and is a pleasure to work with!"
"Dave has made each of my projects sound better. He has a great combination of good skills, is collaborative, and a patient partnership."
"I was super pleased with Dave's professionalism and audio skillset. He had a quick turnaround and delivered an awesome product."
"Dave was great to work with. He completed the work quickly and made sure I was happy with everything. Very responsive to messages and I am thrilled with the final product. Definitely recommend!"
" … an amazing talent for music."
"Very good experience. Good partnership, communication, and good end product. I hope we get to do more together."
"Dave did a great job in a short amount of time putting together the piano music for our musical! Thanks!"
"You are amazing, Dave!"
"Great production, wonderful communication, I'm happy with his work."
"Dave is amazing!"
"Dave is a huge talent. The things he can do musically are astounding."
Filter your view by category, or view all:
Good Lovin'
"Good Lovin'" – Robert Jon & The Wreck
Recorded at Hybrid Studios in Orange County, CA
Produced by Warren Huart
Mixed and Mastered by Dave Merkel
Audio Engineering for Corporate Video
This is one of a series of three videos for which Dave handled the audio engineering: editing, reduce mic bleed, reduce background noise, apply processing effects, and keep the voices riding on top of the music bed.
Cold Days
"Cold Days" – Laura Pataratz
Recorded at Spitfire Studio in LA.
Dave Merkel – remix and master.
Bearded Show Close
"Bearded Show Close" is the closing theme for an ongoing podcast. The melody is from an 1800's Public Domain song, set to a laid-back electronic beat.
Produced by Dave Merkel.
Arrangement & recording Copyright © 2018 Dave Merkel.
I Don't Think We Can Be Friends
"I Don't Think We Can Be Friends" – The Workday Release
Dave Merkel remix
Submitted for the Produce Like A Pro Mixing & Remixing Contest 2019
Courage in the Wilderness
Video trailer soundtrack.
Composed by Dave Merkel for piano, synth strings, and women's choir.
Copyright © 2019, Dave Merkel (ASCAP). All rights reserved.
Sliding Doors
"Sliding Doors" by Kaedyn Kashmir
Produced by multi-platinum producer Warren Huart in Hollywood CA.
Dave Merkel mix & master
"Whiskey" – Steve Maggiora
Produced by Warren Huart – Produce Like a Pro
Dave Merkel mix
A Hundred Lousy Love Songs
"A Hundred Lousy Love Songs" – Chris Sahlin
Dave Merkel mix
Produced by Warren Huart @ Spitfire Music
"Hurricane" – Katey Laurel
Produced by Warren Huart, multi-platinum producer in LA
Dave Merkel mix
Long Way Home
"Long Way Home" – Steve Maggiora
Produced by Warren Huart – Spitfire Studio, LA
Dave Merkel mix
"Conditions" by The Workday Release
Produced by Warren Huart
Dave Merkel mix
Right Here
"Right Here" by Miavono
Remix by Dave Merkel
Piano/Keyboard Live Performance & Tracking Demo
This recording is a mashup of Dave playing a few select but diverse genres on piano. This track gives brief highlights of various playing styles in different genres: classic rock, novelty, classical, kids jazz, pop.
Prelude for the Christ Child
The composer of this song graciously allowed Dave to share his own performance of the song here. It's a beautiful piano piece.
Square Facebook Ad
A square Facebook video ad created for a special video promotion.
Copyright © 2018 Dave Merkel. All rights reserved.
(A Movement of) Mercy & Grace
An original song written by Dave Merkel.
Available on: iTunes, Apple Music, Spotify, Google Play, Amazon, and other online services.
Copyright © 2018 Dave Merkel, ASCAP. All rights reserved.
I'm Not Dead Yet
"I'm Not Dead Yet" by Lovesick Radio
Remix by Dave Merkel
Produced by Warren Huart @ Spitfire Music
Audio Repair Example
Below are two short audio clips. The "before" clip is the audio as it was received, containing excessive and annoying clicks and crackles that distract from the message. The "after" clip is the audio after it was repaired; the clicks have effectively been removed or reduced to an unintelligible level. (Only audio repair results are demonstrated here. No other processing was applied to this audio example.)
Before audio repair:
After audio repair:
Easy Enough
This is the theme song for an online video series.
"Easy Enough" composed by Dave Merkel. Written for upright bass and ukulele, with whistling and hand claps.
Copyright © 2017 Dave Merkel. All rights reserved.
Lurking in the Bayou
Video trailer for Point Lookout
Video trailer soundtrack composed by Dave Merkel
Music Copyright © 2017, Dave Merkel. All rights reserved.
Sophia's Strut
Commissioned as intro theme music for a podcast.
Written for rhythm and horns combo.
Copyright © 2016, Dave Merkel.
The Challenge
Intro theme music for a documentary series on social issues.
Written for full orchestra with boys choir.
Copyright © 2016, Dave Merkel.
A Better Place
No matter who you are—what religion, race, caste or gender—no matter where you live, each one of us has the right to live in freedom, dignity and peace.
"A Better Place" by Playing for Change was released on International Human Rights Day in 2012. This arrangement was written for United Methodist Churches in Montana, Wyoming, Colorado and Utah.
Playing For Change is a multimedia movement created to inspire and bring peace to the world through music. Learn more at Playing for Change at playingforchange.com.
Download the lead sheet (PDF)
Harvest Time
For United Methodists across Montana and northern Wyoming, "Harvest Time" is a theme song, and is associated with "Brother Van". Rev. William Wesley Van Orsdel was a Methodist pioneer in Montana. For more information about Brother Van, see this entry on Wikipedia. Written for Piano/Guitar/Vocal.
Download Piano/Guitar/Vocal score (PDF)
Jesus Loves Me: Variations in C for Piano
An old standard from the 1860's revisited in a new light. Dave was inspired to create this arrangement while spending a relaxing evening at a piano. Music by: William B. Bradbury. Public Domain. Arrangement: Copyright (C) 2009 Dave Merkel.
Click here to download the piano score (PDF)
May the Peace of the Lord Christ Go with You
This song is a Celtic blessing. The wonderful Northumbria Community allowed Dave to share his arrangement, available in Piano/Guitar/Vocal and Piano/SATB.
Copyright © The Blessing in Morning Prayer from Northumbria Community's Celtic Daily Prayer.


text:
Shopbop has the fashions you crave. Shop our collection of chic red swimwear and upgrade your look. We know you'll find your new go-to summer look with in selective assortment of red swimwear. Can you be in love with everything? Yes. New bikinis, one pieces, and cover-ups are just in from our swimwear designers Citrine swim swimwear, Thayer, Tt Beach, Milly bikini top, ISSA, and Wildfox.
Want The VIP Treatment?Sign up for our loyalty program today (and get your perks).Join Now


text:
Its important you do a risk assessment in the workplace and as long as its a lost risk environment then this is ideal for you and your company.
You can gain more information from the HSE website.
So want to know what we cover?
Role and Responsibilities of first aider:
Infection control Consent,
First aid equipment Incident reporting
Scene survey, primary survey, calling for help/information needed
CPR and AED
Recovery position
Management of a seizure
Choking casualty
Types, recognition and treatment
Bleeds and treatment
Small cuts Grazes Bumps and bruises small splinters Minor burns During the training your trainer will be assess you and you will have a multiple question paper.
We are busy having fun making these videos but they are not quite ready yet.
Whats happening? You will be able todo blended course on EFAW so you do 3 hours online then a trainer will come and finish the last few bits before assess your practical and carryout a small test paper.
Advertisements below
Shadoxhurst (/ˈʃædɒkshɜːrst/) is a civil parish[2] and a village on the remnant forest the Kent Weald, near Ashford in Kent, England between the Greensand Ridge and Romney Marsh.
Part of the vestige of county-sized woodland known as The Weald, Shadoxhurst is mostly wooded countryside and farmland.[3] with the Whitewater Dyke (a tributary of the River Stour) rising in the area.
office supplies near to Shadoxhurst
"MY EYES look FOR YOU; MY HEART BLEEDS THE solution -- MY excitement ENTERS YOUR SOUL extremely." ~ Jesus ~ My response: As I contact my Bible I gain the feeling someone is looking at me I approach my head to see Who It is You, Jesus my Savior Your eyes see into mine I setting You can see into my soul silently You say me You adore me Thank You for swine compliant to free me even even though You look my sins even even if I hurt You I tone Your unstoppable dull pain caused by anything my sins they're beating You in front of me I refuse to shout "Crucify Him!" as soon as the crowd yet I take God's Will Thank You for taking my place It will not be easy to watch You die Will I have to close my eyes Will me swine there comfort You I hope appropriately (Luke 23:21) Now I stare on the One I have pierced I take Your blood & water flowing healing my soul I'm sorry I adore You, Lord I reach up venerating Your Cross (John 19:34-37) I stayed Where else would I go I motto Your Heart bleeding blood with utter droplets of Gospel I wish I could have healed You then but this is above and greater than a First Aid situation I needed anything Your artificial Blood through Your wounds I am healed Thank You for transfusing my heart afterward Your unquestionable, Grace, energy (1 Peter 2:24) I hope I could withhold You in my arms but I know that is Your mother's role I stand by her side while for moral support and she lets me withhold Your lifeless hand I'm red-handed and it's my fault I hope I could retain it forever or never wash my hand again to prove my adore radical devotion But they are going to accept You away from me into the frosty tomb 3 days feels gone in view of that long to wait I hope I could hibernate in prayer too in there later you, sadly praying by Your body I just have to wait bearing in mind trust I take You will rise again bearing in mind You told us After 3 days of insomniac hope I go like them my eyes see for You The tomb is already right of entry I wish they had let me stay I would have been let out they didn't bow to but I believed You You search for my eyes We are reunited no one can accept you away at least not forever You wash my still-red hand :) I know You adore me me personally I support Your clean hand I kiss the nail mark Your rays of Divine Mercy now unbloody, unwatery considering a touchless hug of perpetual Mercy like seeing The Light I trust You, Jesus definitely! Jesus' reply to me (based upon Colossians 1:24) "BY put it on THE ABOVE -- REACHING UP... YOU supreme ME."


text:
This article will be permanently flagged as inappropriate and made unaccessible to everyone.
Are you certain this article is inappropriate?
Excessive Violence
Sexual Content
Political / Social
Email Address:
Article Id:
Reproduction Date:
Rómulo Díaz de la Vega (23 May 1800 — 3 October 1877) was de facto president of Mexico in 1855.[1] He studied military science and rose to the rank of general
In 1821 he joined the Plan of Iguala. He fought in the Texas War of Independence and for that he was appointed lieutenant. He fought in 1838 against the French invasion during the Pastry War. He also fought in the Mexican-American war and he was captured at the Battle of Resaca de la Palma on May 9, 1846.[1][2]
Díaz de la Vega was military commander of Puebla in 1849 and Tamaulipas in 1850 and then Governor of Yucatán in 1853.
When Martín Carrera left the presidency of the Republic in 1855, Díaz de la Vega supported by the leaders of the military garrison, assumed the duties of President while someone else came to Mexico City to relieve him in office.[3] His government lasted 22 days, from 12 September to 3 October 1855.
After his presidency, Díaz de la Vega was a member of the group of the conservatives who appointed Maximilian of Habsburg as emperor in 1863. After the triumph of the Republic, he was sentenced to be two years imprisonment but the penalty was switched by confinement in Puebla, where he died in October 1877, exactly twenty-two years to the day his tenure as President ended.[1]
New Spain, Mexico, Mexican Revolution, San Luis Potosí, Antonio López de Santa Anna
Mexican Revolution, Coahuila, Manuel Gómez Pedraza, Luis G. Vieyra, Authority control
Spanish language, Surname, Zorro, La Vega Province, Nobility


text:
They are a useful and effective tool that allow you a structured means in which to entrain your brain into a desired, new brainwave state using an intended set frequency range of the audio track. Frequency ranges for desired sleep, recovery and deep meditation states to different/higher frequency ranges for performance "flow-states" and high-level focus and calculation.
* Headphones/Earbuds are Required for Binaural Tones to be Effective as the Left Ear and Right Ear Audio must be isolated for the Brain to perceive the inaudible low-frequency difference between the two sides. ** Changes to Orientation Support: With the upcoming arrival of several new devices with new screen-sizes and aspect ratios, iOS 8 required a re-write of our iPhone and iPad UI to support these devices, and as part of that, we have returned the app to a Portrait-only view for now. Once we know what these future screen dimensions and Aspect Ratios are, and have time to work with the real devices, we can implement a new Landscape UI for the iPad.
Different states of mind are associated with specific brainwave frequencies that would be inaudible if played directly. These frequencies can be induced in the brain indirectly by playing two different audible tones into each ear, which after being processed by the brain, are perceived as an inaudible beat matching the target brainwave frequency. As you listen, your own brainwaves fall into step with this inaudible beat, and after a few minutes synchronize with the target brainwave frequency. Brain Wave's 35 programs layer these binaural sequences into multi-stage sessions that have helped thousands of people focus and concentrate, feel positive and motivated, and sleep more soundly.
Another study found slight improvements in trait anxiety as a result of entrainment. It was noted that the study with the most successful protocol started at 30 Hz beta and ramped the frequency down until the person experienced relaxation for 15 minutes. This was then followed with a session of 8 Hz to 14 Hz for 7 minutes. The results suggested that 75% of individuals improved on their measures of long-term stress.
Thanks for making Brain Wave the Top-Selling Brainwave Entrainment App in the App Store! * This update includes support for iOS 6, an optimized UI for iPhone 5, and a new ambient forest background. The app is universal, so you get it across all your devices with one app! Includes optimized UIs for iPhone/iPod Touch, iPhone 5, iPad and support for landscape and portrait orientations.
I'm kind of new to brainwave entrainment. So even though I might have been skeptic at first, my very first experience was rather surprising. I know, I'm probably among millions of people expressing the effects and benefits of brainwave enhancing auditory stimuli. But truth be told, if you have the right tone, the perfect serene place, and an unshakable determination? Then you're on the right track. So I'd say? Give brainwave entrainment a try. You're bound to feel the great benefits of these powerful, yet simple methods of mental boosters. Oh! Before I forget. Thank you for the interesting script mademoiselle. 🙂
Isochronic tones are basically just a single tone with the volume being turned on and off at regular intervals. When you apply the same effects to music or a noise, it's usually referred to as amplitude entrainment effects (in Mind Workstation anyway). When you apply the on/off effect to music or noise it's usually done by targeting a specific frequency range in the sound and only turning that part on/off, leaving the rest of the music/noise untouched. What that does is allow parts of the music/noise to play without being distorted/interrupted, making it sound more pleasant to listen to. It produces a kind of fluttering sound as I like to call it and you can adjust the level of intensity.
my daughter had an EEG and the neurologist said the brain wave activity in the back of her brain was very slow. I want to find out what causes this. She had a brain injury (3 skull fractures that were in the right side of her head and across the front right side. The fractures were closed wound. She had a small amount of swelling which diminished on it's own. The neurologist asked if the fractures were in the back of her head and I told her no. She had no explanation for me.
PPPS. You won't BELIEVE the amazing change that YOU are about to experience. I've seen thousands of individuals undergo powerful shifts in their consciousness as a result of using this program. It's EMPOWERING, and it's available right now after 10 years of intensive testing and refining. Discover the magic for yourself! Purchase the CD version, or the download version!
At a certain point (generally after about four to six months), your brain will have made all the changes it needs to make to handle the Holosync® we use in Awakening PrologueTM. At that point you're like a runner who's been running two miles a day for several months, and now two miles is easy, because the body has created the physical structure that can easily handle it.
I have purchased several brain entrainment CDs, all of which have cost far more than the one I am using from the EOC Institute. Without a doubt, your CD outperforms the other ones hands down. It is nice to know that there are companies out there that truly put the customer first instead of the "ALMIGHTY DOLLAR" Thank you so much for your excellent product. It is a big help.
Theta waves have a frequency between 4 and 7.5 hertz, making them slower than more wakeful alpha but faster than the dreamless slumber of delta. Theta brainwaves are the frequencies of nighttime dreams and REM sleep when the brain goes through bursts of activity and eye movement. People also experience theta waves in a state of light sleep, deep relaxation, during meditation and prayer, and when daydreaming. Theta waves produce an experience of inward wakefulness where we become disengaged from the outside world while engaging in inner activity. At the lower frequencies of theta, sleeping states are experienced, and at the higher range of frequency, awake relaxed states are experienced.
* There are a lot of new features in this release so please take a moment to review the updated help for information on how to use them. As always, if you have any issues or suggestions please drop us an email at email@example.com so we can respond with any follow up questions we may have. We always try to incorporate user requests, and this update is packed with them, so please keep them coming and we hope you enjoy the update!
Beta stimulation: There is evidence that stimulation within the beta range can improve attention, measures of intelligence, relieve short-term stress, decrease headaches, and decrease behavioral problems. Some evidence even suggests that beta could decrease emotion-based exhaustion. Many people with slower frequency brain waves may benefit from regular beta stimulation.
BrainAscend is a completely free meditation program featuring 5 deepening levels, meaning 5 free MP3 tracks using brainwave entrainment technology, created by Marcus Knudsen, inventor of BlissCoded sound. It uses the scientifically proven most effective brainwave entrainment technology in a special process that steadily expands your brain power and consciousness level.
Brainwave entrainment music can be used almost anywhere and anytime, making this mood and self-improvement method versatile and flexible enough to do at work, while traveling, or at other times during the day. When used in the workplace during short rest periods, brainwave entrainment techniques can enhance concentration, communication, and work productivity.
Gamma waves are the fastest brainwave frequency range. Gamma brain waves are believed to link and process information from all other parts of the brain. A high amount of gamma wave activity in the brain is associated with intelligence, compassion, focus and feelings of happiness. High levels of gamma brain waves have also been linked to improved memory and an increased sensitivity to sensory input. Low amounts of gamma brainwave activity have been linked to learning difficulties, poor memory and impaired mental processing.
Delta (3hz – 0.2hz) – Deep, dreamless sleep. Intuition. Empathy. Brainwave expert Judith Pennington calls it the doorway to Universal Consciousness and "A radar that scans the environment and psychically picks up information and energy." According to British physicist C. Maxwell Cade "There have been reports that delta waves appear at the onset of paranormal phenomena." (More information can be found in Cade's book The Awakened Mind)
Isochronic tones are basically just a single tone with the volume being turned on and off at regular intervals. When you apply the same effects to music or a noise, it's usually referred to as amplitude entrainment effects (in Mind Workstation anyway). When you apply the on/off effect to music or noise it's usually done by targeting a specific frequency range in the sound and only turning that part on/off, leaving the rest of the music/noise untouched. What that does is allow parts of the music/noise to play without being distorted/interrupted, making it sound more pleasant to listen to. It produces a kind of fluttering sound as I like to call it and you can adjust the level of intensity.
You've probably heard people talk about the power of "positive thinking." While some might tell you that it's based on faith or strong belief, research has shown that there's a third ingredient that helps you get that frame of mind – Alpha brainwaves. The rhythm produced by this brainwave – especially those that hit the frequency of 10 Hz – is said to help in the enhancement of one's mood and thoughts, enabling one to experience and enjoy a positive state of mind.
Hi. This article contains a lot of information about brainwave entertainment. Thanks. I have a question. I downloaded an Android app that plays isochronic tones. I like to use an Isochronic tone at 2.5Hz that is in Delta range and is supposed to help me get a deep and dreamless sleep. I use it without headphones and just keep the smartphone next to my pillow. But I do not know if I should keep the tone playing all the time while I sleep or put it on timer to shut off after some specified time. A custom timer is possible with the app. Can you please guide me.
But here is where I'd like to chime in my own two cents. As a user of brainwave entrainment products for over 8 years now, you would obviously have to guess that I think this technology is fabulous. Even my earlier experiences with brainwave entrainment technology using less refined binaural beats were nothing short of miraculous for me. It's a very fascinating experience to go from not being able to meditate at all to being able to sit with your eyes closed and headphones on and effortlessly slip down into deep brainwave states that were previously only reserved for years-long experienced meditators.
Discovered by Austrian Psychiatrist Hans Berger in 1908, Alpha brainwaves cycle 8 to 13 times per second, a good bit slower than beta brainwaves. While considered a part of a group of brainwaves, the Alpha brainwave has one distinct trait that makes it stand out from its siblings – it appears and disappears while going through our brain. Sometimes alpha waves are present, sometimes they are not. The disappearance of the Alpha brainwave usually occurs when someone is asleep or experiences heightened emotions such as fear or anger. This brainwave only appears whenever a person is awake and relaxed, a one-of-a-kind distinction among other types of brainwaves.
Going back to the technology, the simple claim of brainwave entrainment is that, by listening to these audios, usually with stereo headphones and eyes closed, your brain will be naturally and effortlessly led into a specific brainwave state as designated by the maker of the audio (ie: it could be alpha, theta, delta, gamma, etc., depending on what the audio is designed to do.) The other most basic claim is that when listening to these audios, the right and left hemispheres of the brain synchronize and you experience whole-brain functioning.
A very pleasurable experience during listening (and often for some time afterwards). As Holosync® changes your brain wave patterns to those of deep meditation, the brain produces several very pleasurable neurochemicals, including endorphins (the same endorphins responsible for "runner's high")…as well as several hormones with a profound and positive effect on longevity, aging, stress, and well-being.
Mood: While brainwave entrainment may not be a great option for depression, particularly in the slower frequency ranges, beta entrainment may improve certain measures of mood. Additionally it is important to consider the fact that many people experience detrimental changes in mood as a result of heightened stress and anxiety. Since brainwave entrainment has been shown to improve stress and relaxation, overstressed individuals may experience a simultaneous mood improvement.
Dissociative but not present. In college I started having difficulty with reading comprehension/absorption (not dyslexia, I could read everything out loud easily but not gather the meaning). Over the past two years or so, my memory has been concerning, as I am not middle or late aged. Since it had been getting worse, I have been researching for several years now for a cure. Biofeedback led me to neurofeedback (which I can't afford at the moment).
Meanwhile, the therapeutic benefits of listening to sound and music is a well-established principle upon which the practice of receptive music therapy is founded. The term 'receptive music therapy' denotes a process by which patients or participants listen to music with specific intent to therapeutically benefit; and is a term used by therapists to distinguish it from 'active music therapy' by which patients or participants engage in producing vocal or instrumental music.[37] Receptive music therapy is an effective adjunctive intervention suitable for treating a range of physical and mental conditions.[38]


text:
Offering exclusive content not available on Pornhub. Welcome to our website! We feature only the best busty teens and big titted women, starring in % exclusive photos and videos, so you wont find them. This website contains age restricted materials!
Offering exclusive content not available on Pornhub. See sexy amateur girls with large naked breasts flaunting them in naughty free picture galleries. Juliana Simms looks hot in a stretchy black dress showing a glimpse of some impressive cleavage.
Busty Babes. Watch Nude Women Large Breasts porn videos for free, here on acnenomorereviewed.info Discover the growing collection of high quality Most Relevant XXX movies and. Hot and busty Russian teen stripteases in the kitchen.
Offering exclusive content not available on Pornhub. The Pornhub team is always updating and adding more porn videos every day. We have a huge free DVD selection that you can download or stream. Pornhub is the most complete and revolutionary porn tube site.
If you love busty teen girls and pics of nude teens with big naked boobs then you will love largeteenboobs. I wish i could see the dildo going in her pussy Then EAT acnenomorereviewed.info eyes."Look at me." I want to feel our naked animal thoughts loose control first and come. If you are a major fan of hot women with huge breasts, make sure to take a peek at amazing photos on bigboobsbeauties.
people on Pinterest. See more ideas about Beautiful Women, Beauty and Boobs. See more. L C ## Bigger Breast, Sexy, Curvy Models, Big Basket, Naked.
Beautiful Big Breasts posing nude for Met-Art in a sexy photo gallery at Morazzia. Visit us for more sex photos and porn pictures.
Watch Beautiful Naked Large Breasted Women Videos on acnenomorereviewed.info, the biggest free porn tube.


text:
Investing in Solar: Company Checklist
Investing in solar should be an exciting and rewarding experience for a home or business owner, but now more than ever, there seems to be bountiful amounts of advice on which companies to trust, which panels work best, and what a typical system should look like. Unfortunately much of this advice does not come from a reputable source, and consequently we often see or hear of installations that do not last long, don't pass industry standards and can't be turned on, or don't even happen once the money is taken. By the time SolarHub gets involved, if it is often late enough into the experience that the consumer has spent a large amount of money and time, and is at their wits-end with the solar industry. And fair enough too! But in saying that, it is not all doom and gloom in solar, and by using a few tools you can help to ensure you don't fall trap to a bad companies experience, and instead work with a reputable business so that your system sees many sunny days.
Clean Energy Council Accredited
The Clean Energy Council (CEC) is the peak body for the clean energy industry in Australia, representing hundreds of businesses in solar, wind, energy efficiency, hydro, bioenergy, energy storage, geothermal and marine. The CEC code of conduct sets a high bar for the solar industry and protects you as the consumer from unscrupulous operators and poor quality installations. By choosing a company that is accredited, like SolarHub, it means they are held to strict standards and regulations in regard to ethical marketing practises, and excellent customer- service. They offer a comprehensive list on their website of all the accredited installers in your area.
Operational Years
Longevity in the market will help demonstrate years of valued experience in the solar industry, and that the company is much less likely to operate as a take-your-money-and-dash scam if they have set up roots and operated for several years. It should also mean that they have stuck around long enough to build a reputation, or enough reviews online so that you can search for them and find out exactly the quality of work that they provide.
Online Reviews
And speaking of online reviews- these aren't there just to boost star points for a company, but instead offer real-life customer reviews of the company you are interested in. Take advantage of third party reviews websites such as product review, or solar quotes which will offer a range of opinions, and won't just be a selection of favourite testimonials the company has chosen. Alternatively if these don't answer all your questions, try an online forum to ask the community for advice.
Sometimes parts break, or get damaged- and even if you think you have chosen a company that you thought was going to stick around, it is important to also consider the products they use. Ensure the brands they are installing have a decent warranty attached to them, and ask about the process should anything ever go amiss with either the brand that is installed, or the company.
And finally, ensure that the company is transparent about any hidden costs. Ask about meter-box upgrades, inspection, or antenna relocation fees for example. SolarHub sends a sales representative to your home to discuss your energy needs, see your home, and customise a report for you based on these requirements- outlining any fees included. This process is ideal for any new solar buyers as it will help them purchase a system based on their individual needs, and not hide any secret costs.
If you would like to work with a reputable solar company, or want to find out more about how solar can benefit you- contact us today at SolarHub.


text:
Gingko Leaf - Gold
Gingko Leaf - Gold
from 75.00
The amazing pendant conserves a real Gingko leaf inside 14K Gold.
➳ Silver chains in 40 cm (15'') or 60 cm (23'') can be purchased separately here.
➳ All the leaves are ready to ship
➳ You can check our shipping and payment policy here.
➳ For information on how to care for this item, check our Care of Items Page.


text: Expanded Resources for Veterans in Booth's MBA Comments Posted By FT Admissions November 12, 2018 The University of Chicago celebrated our military-affiliated students on Friday with an annual recognition event and keynote speech from alumnus Eric Gleacher, MBA '67, who was formerly in the Marine Corps and has established a permanent scholarship fund for veterans seeking an MBA from Chicago Booth. The formation of a new university-wide Office for Military-Affiliated Communities was also announced this week, serving to amplify the range of programs, support services, and partnerships already in place. Chicago Booth has a history of commitment to diversity and inclusion that values applicants from all walks of life and industry backgrounds, including those coming from military services around the globe. Booth recently doubled its contributions under the Yellow Ribbon Program, part of the Post-9/11 GI Bill. Qualifying veterans now receive up to $30,000 in benefits from the school. This is a significant expansion of Booth's participation in the program, which has been in place at the school since 2008. Our Armed Forces Group (AFG) is very active in supporting veterans throughout every stage of their MBA journey, even during the admissions process. AFG provides active MBA application mentorship and various resources to veterans who are interested in applying to Chicago Booth. Consisting of Booth students who have served or are currently serving in the armed forces of their respective countries, AFG strives to build a strong professional network of Booth alumni and current students with previous military experience. The group welcomes new members and their families to the Chicago area through a variety of social activities. They also help students through the recruiting process with career coaching, resume workshops, and interview preparation. Last year, the University partnered with the Army Research Laboratory (ARL) to establish ARL Central, a regional headquarters for research and technology development based at the Polsky Center for Entrepreneurship and Innovation. The joint venture allowed ARL researchers to interact in new ways with leading scientists and researchers at the University of Chicago and other collaborating universities in the areas of materials and data sciences. Some faculty have focused their studies on improving healthcare for veterans. For instance, professor Robert L. Grossman is collaborating with the Boston VA to develop a system that will allow better analysis of one of the nation's largest datasets for cancer genomics and clinical data. The undergraduate college at the University has also increased its efforts in recruitment, enrollment, and support of veterans and their dependents through partnerships with the Posse Foundation. The foundation has a program that prepares veterans to begin their undergraduate education and provides mentoring throughout their experience. Learn about all of the university-wide resources available to veterans at Chicago Booth and hear from our current Booth students in the Armed Forces Group. The application fee is waived for all military-affiliated candidates, so start your application today » Share this page


text:
Anal sex retro classic german
Bdsm anal sex machine
hot young teen like sex and anal
Squirting Anal Sex
Lucie Wild First Anal Sex SZ363
Anal sex copilacion
Rough anal sex
Anissa Kate Amazing Sensual Anal Sex
Anal all anal cream pie
Gorgeous teen anal sex
Short Hair Teen Anal Sex
First Anal Sex(1)
Mature granny has anal sex
lolabarbie1 - Anal Sex
Beauty Anal Sex
Extreme Anal Sex Games
Florane anal Sex with Boss in hotel room
Mom teacher anal sex
Sex Tape With Wet Big Ass Girl Having Anal mov-05
Anal with bottle
Culiando rico
All models were 18 years of age or older at the time of depiction.
bigttits.com has a zero-tolerance policy against illegal pornography.
© Copyright Bigttits.com 2019


text:
|Psa 2:4
The one enthroned 1 in heaven laughs in disgust; 2 the Lord taunts 3 them.
|Psa 22:3
You are holy; you sit as king receiving the praises of Israel. 1
|Isa 24:17
Terror, pit, and snare are ready to overtake you inhabitants of the earth! 1
|Num 13:29
The Amalekites live in the land of the Negev; the Hittites, Jebusites, and Amorites live in the hill country; and the Canaanites live by the sea and along the banks 1 of the Jordan." 2
|Deu 1:4
This took place after the defeat 1 of King Sihon 2 of the Amorites, whose capital was 3 in Heshbon, 4 and King Og of Bashan, whose capital was 5 in Ashtaroth, 6 specifically in Edrei. 7
|1Ch 3:20
The five others were Hashubah, Ohel, Berechiah, Hasadiah, and Jushab-Hesed.
|Jer 48:43
Terror, pits, and traps 1 are in store for the people who live in Moab. 2 I, the Lord, affirm it! 3
|Gen 24:62
Now 1 Isaac came from 2 Beer Lahai Roi, 3 for 4 he was living in the Negev. 5
|Num 14:25
(Now the Amalekites and the Canaanites were living in the valleys.) 1 Tomorrow, turn and journey into the wilderness by the way of the Red Sea."
|Jdg 1:9
Later the men of Judah went down to attack the Canaanites living in the hill country, the Negev, and the lowlands. 1
|Pro 3:29
Do not plot 1 evil against your neighbor when 2 he dwells by you unsuspectingly.
|Pro 20:8
A king sitting on the throne to judge 1 separates out 2 all evil with his eyes. 3
|Isa 5:3
So now, residents of Jerusalem, 1 people 2 of Judah, you decide between me and my vineyard!
|Jer 36:22
Since it was the ninth month of the year, the king was sitting in his winter quarters. 1 A fire was burning in the firepot in front of him. 2
|Jer 48:9
Set up a gravestone for Moab, for it will certainly be laid in ruins! 1 Its cities will be laid waste and become uninhabited."
|Jer 51:37
Babylon will become a heap of ruins. Jackals will make their home there. 1 It will become an object of horror and of hissing scorn, a place where no one lives. 2
|Gen 24:3
so that I may make you solemnly promise 1 by the Lord, the God of heaven and the God of the earth: You must not acquire 2 a wife for my son from the daughters of the Canaanites, among whom I am living.
|Jos 9:7
The men of Israel said to the Hivites, "Perhaps you live near us. 1 So how can we make a treaty with you?"
|Jdg 1:17
The men of Judah went with their brothers the men of Simeon 1 and defeated the Canaanites living in Zephath. They wiped out Zephath. 2 So people now call the city Hormah. 3
|Jdg 4:2
The Lord turned them over to 1 King Jabin of Canaan, who ruled in Hazor. 2 The general of his army was Sisera, who lived in Harosheth Haggoyim. 3


text:
Post a comment This video has not been commented yet. PornHub Caroline Pierce XOZilla Lisa Ann Date Anytime Last 3 days This week This month Last 3 months Last 6 months. Fist Flush presents Suzie Carina and Niki Carlt Analdin Brandi Love Cherie Deville 7:
Yoummy Porn Tube Busty bound and gagged by two guys Report 01m: Photoshoot gets really hot Report 06m: Lucky Bastard Analyzed hot twins Report 30m: Two bound babes caned by master Report 01m: Lonely blonde gets fucked in bar Report 06m:
lesbian-threesome videos - SMARTORDER.PRO
In der Bar Report 02m: Hot lesbian threesome with the babysitter. Emilius, Top Arab Masseur Report 08m: Daring Public Sex Street Threesome. Perfect Sex Tubes
Threesome Tube Videos
Description: All videos are hosted by 3rd party websites. My Loved Tube Surprise at office vm Report 03m: We do not own, produce or host the videos displayed on this website.
Views: 3193 Date: 26.03.2017 Favorited: 5
User Comments
Basically, your brain predicts what should be the outcome of any movements you make. Therefore you cannot accurate feel what you are feeling, because your brain is telling you what you should be feeling, whether or not you actually feel it. If someone else touches you, you wont have the same predictions and you will feel things differently.
I spy for twats and if I got my boner I jack off under water ( as so many others do too)
There is one good reason for having separate bathrooms for men and women, and in my last two jobs it was the same (even if it started as unisex): Men have a piss poor aiming (pun not intended but appreciated none the same!).


text:
Spruce Wallpapers 39081
Download the following Spruce Wallpapers 39081 image by clicking the orange button positioned underneath the "Download Wallpaper" section. Once your download is complete, you can set Spruce Wallpapers 39081 as your background.
Looking for more wallpapers? Check out the HDWallSource blog to browse a variety of wallpaper collections.
Wallpaper DetailsFile Name: Spruce Wallpapers 39081 Category: Nature Resolution: 1920x1200px Filesize: 319.98 KB Views: 1553 times Tagged : Spruce, Wallpapers, 39081, Market: hdwallsource.com/market Blog: blog.hdwallsource.com
Share Wallpaper
Download Wallpaper
Following the click of the download button, right click on the Spruce Wallpapers 39081 image and select 'save as' to complete your download.


text:
Reading Restaurants
Checking out the jerk chicken and the rice and peas at new Jamaican restaurant Vibes Caribbean to see if could encourage more Reading diners to try Caribbean cuisine.
Get a sneak peek at the menu and discover what to eat at the exciting regional Indian restaurant set to open on London Street in June, including clay pot biryiani, stone grilled lamb and more.
Test the waters and the menu on a spa day at Thames Lido. Is Reading's gloriously restored luxury outdoor swimming pool and restaurant worth the price tag?
Honest Burgers, Reading's latest burger joint serves up quality British produce and pink patties from an impressive, buzzing Market Place restaurant.
Reading heritage
Explore View Island, a peaceful spot for nature along the River Thames, and only a five minute walk away from Reading train station.


text:
Serine is both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical pathway of glucose-derived serine synthesis, Homo sapiens phosphoglycerate dehydrogenase (PHGDH) catalyzes the first, rate-limiting step. Genetic loss of PHGDH is toxic toward PHGDH-overexpressing breast cancer cell lines even in the presence of exogenous serine. Here, we used a quantitative high-throughput screen to identify small-molecule PHGDH inhibitors. These compounds reduce the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells in culture and in orthotopic xenograft tumors. Surprisingly, PHGDH inhibition reduced the incorporation into nucleotides of one-carbon units from glucose-derived and exogenous serine. We conclude that glycolytic serine synthesis coordinates the use of one-carbon units from endogenous and exogenous serine in nucleotide synthesis, and we suggest that one-carbon unit wasting thus may contribute to the efficacy of PHGDH inhibitors in vitro and in vivo.
tert-butyl 4-(4-(trifluoromethyl)benzyl)piperazine-1-carboxylate
4-(4-(trifluoromethyl)benzyl)piperazin-1-ium trifluoroacetate
Access optionsAccess options
Subscribe to Journal
Get full journal access for 1 year
only $16.33 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Change history
- 1.
Tibbetts, A.S. & Appling, D.R. Compartmentalization of mammalian folate-mediated one-carbon metabolism. Annu. Rev. Nutr. 30, 57–81 (2010).
- 2.
Locasale, J.W. Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat. Rev. Cancer 13, 572–583 (2013).
- 3.
Farber, S., Diamond, L.K., Mercer, R., Sylvester, R. & Wolff, J. Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. N. Engl. J. Med. 238, 787–793 (1948).
- 4.
Vander Heiden, M.G. Targeting cancer metabolism: a therapeutic window opens. Nat. Rev. Drug Discov. 10, 671–684 (2011).
- 5.
Cantor, J.R. & Sabatini, D.M. Cancer cell metabolism: one hallmark, many faces. Cancer Discov. 2, 881–898 (2012).
- 6.
Labuschagne, C.F., van den Broek, N.J.F., Mackay, G.M., Vousden, K.H. & Maddocks, O.D.K. Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells. Cell Rep. 7, 1248–1258 (2014).
- 7.
Maddocks, O.D.K. et al. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 493, 542–546 (2013).
- 8.
Snell, K., Natsumeda, Y., Eble, J.N., Glover, J.L. & Weber, G. Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma. Br. J. Cancer 57, 87–90 (1988).
- 9.
Snell, K. & Weber, G. Enzymic imbalance in serine metabolism in rat hepatomas. Biochem. J. 233, 617–620 (1986).
- 10.
Fell, D.A. & Snell, K. Control analysis of mammalian serine biosynthesis. Feedback inhibition on the final step. Biochem. J. 256, 97–101 (1988).
- 11.
Possemato, R. et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476, 346–350 (2011).
- 12.
Locasale, J.W. et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat. Genet. 43, 869–874 (2011).
- 13.
Chen, J. et al. Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth. Oncotarget 4, 2502–2511 (2013).
- 14.
Mattaini, K.R. et al. An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation. Cancer Metab. 3, 5 (2015).
- 15.
DeNicola, G.M. et al. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nat. Genet. 47, 1475–1481 (2015).
- 16.
Zhang, W.C. et al. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 148, 259–272 (2012).
- 17.
Kim, D. et al. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature 520, 363–367 (2015).
- 18.
Chaneton, B. et al. Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature 491, 458–462 (2012).
- 19.
Fan, J. et al. Quantitative flux analysis reveals folate-dependent NADPH production. Nature 510, 298–302 (2014).
- 20.
Nilsson, R. et al. Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer. Nat. Commun. 5, 3128 (2014).
- 21.
Lund, K., Merrill, D.K. & Guynn, R.W. The reactions of the phosphorylated pathway of L-serine biosynthesis: thermodynamic relationships in rabbit liver in vivo. Arch. Biochem. Biophys. 237, 186–196 (1985).
- 22.
Chakraborty, S., Sakka, M., Kimura, T. & Sakka, K. Characterization of a dihydrolipoyl dehydrogenase having diaphorase activity of Clostridium kluyveri. Biosci. Biotechnol. Biochem. 72, 982–988 (2008).
- 23.
Inglese, J. et al. Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc. Natl. Acad. Sci. USA 103, 11473–11478 (2006).
- 24.
Di, L. & Kerns, E.H. in Solvent Systems and their Selection in Pharmaceutics and Biopharmaceutics (eds. Augustijns, P. & Brewster, M.E.) (Springer, New York, 2007).
- 25.
Foley, T.L. et al. 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth. J. Med. Chem. 57, 1063–1078 (2014).
- 26.
Hamiaux, C. et al. DAD2 is an α/β hydrolase likely to be involved in the perception of the plant branching hormone, strigolactone. Curr. Biol. 22, 2032–2036 (2012).
- 27.
Walsh, M.J. et al. ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model (National Center for Biotechnology Information, 2010).
- 28.
Anastasiou, D. et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat. Chem. Biol. 8, 839–847 (2012).
- 29.
Birsoy, K. et al. An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis. Cell 162, 540–551 (2015).
- 30.
Sullivan, L.B. et al. Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells. Cell 162, 552–563 (2015).
- 31.
Narkewicz, M.R., Sauls, S.D., Tjoa, S.S., Teng, C. & Fennessey, P.V. Evidence for intracellular partitioning of serine and glycine metabolism in Chinese hamster ovary cells. Biochem. J. 313, 991–996 (1996).
- 32.
Young, L., Sung, J., Stacey, G. & Masters, J.R. Detection of Mycoplasma in cell cultures. Nat. Protoc. 5, 929–934 (2010).
- 33.
Kuzmic, P. Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. Anal. Biochem. 237, 260–273 (1996).
- 34.
Luo, B. et al. Highly parallel identification of essential genes in cancer cells. Proc. Natl. Acad. Sci. USA 105, 20380–20385 (2008).
- 35.
Wang, T., Wei, J.J., Sabatini, D.M. & Lander, E.S. Genetic screens in human cells using the CRISPR-Cas9 system. Science 343, 80–84 (2014).
- 36.
Cho, K. et al. isoMETLIN: a database for isotope-based metabolomics. Anal. Chem. 86, 9358–9361 (2014).
We thank T. Wang and E. Edenberg for critical reading of the manuscript, S. Murphy for assistance with mouse experiments, and J. Pacold of the Lawrence Berkeley National Laboratory for assistance in interpreting Tm data. This research is supported by the Sally Gordon Fellowship of the Damon Runyon Cancer Research Foundation (DRG-112-12), a Department of Defense Breast Cancer Research Program Postdoctoral Fellowship (BC120208), and an ASTRO Resident Seed Grant (RA-2011-1) (all to M.E.P.)., by Susan G. Komen for the Cure (grant to R.L.P.), by an EMBO Long-Term Fellowship (to M.A.-R.), by the NIH (R03 DA034602-01A1, R01 CA129105, R01 CA103866, and R37 AI047389 to D.M.S.), by the US Department of Defense (W81XWH-14-PRCRP-IA to D.M.S.) and by the Stewart Trust (to D.M.S.). D.M.S. is an investigator of the Howard Hughes Medical Institute.
Supplementary information
PDF files
- 1.
Supplementary Text and Figures
Supplementary Results, Supplementary Table 1 and Supplementary Figures 1–9.
- 2.
Supplementary Note
Synthetic Procedures
Excel files
- 1.
Supplementary Data Set 1
Selectivity profile of NCT-502, NCT-503 and inactive compound. The activity of NCT-502, NCT-503 and the inactive compound was tested against a panel of 168 GPCR candidates.
Rights and permissions
To obtain permission to re-use content from this article visit RightsLink.
About this article
Publication history
Further reading
Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing
Nature Communications (2019)
Activation of LXR β inhibits tumor respiration and is synthetically lethal with Bcl‐ xL inhibition
EMBO Molecular Medicine (2019)
The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism
Nucleic Acids Research (2019)
Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution
Proceedings of the National Academy of Sciences (2019)
Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation
Journal of Clinical Investigation (2019)


text:
|Tata Motors formally opens assembly plant in South Africa at Rosslyn
|Written by Vivek
|Saturday, 23 July 2011
Mumbai: Tata Motors (SA), Tata Motors' joint venture with Tata Africa Holdings, today, formally opened its assembly plant in South Africa at Rosslyn, north of Pretoria, in the Gauteng province of South Africa. Established with an investment of R110 million, the plant can assemble, from semi knocked-down (SKD) kits, light, medium and heavy commercial vehicles ranging from 4 tonnes to 50 tonnes, with an annualised capacity of 3,650 vehicles.
The capacity can be further expanded as required. The plant has been awarded with ISO 9001 accreditation by Bureau Veritas, South Africa. To begin with, it is assembling two models, the Tata LPT 813 and Tata LPT 1518, both already popular in South Africa.
The plant was inaugurated by Rob Davies, South Africa's minister of trade and industry, in the presence of top dignitaries from South Africa and India. Among them were Noel Tata, managing director, Tata International; Carl-Peter Forster, group CEO and managing director, Tata Motors; Raman Dhawan, managing director, Tata Africa; as well as dealers and key associates of the company.
|Related news
|More recent
|Earlier on


text:
Cottages near Windsport International
We've got 141 holiday cottages within 5 miles of Windsport International. You can refine your search using the controls below.
We have 141 self catering cottages near Windsport International to show you...
7 nights from £458
Trefusis Lodge3800
3 bedroom, dog friendly cottage near the beach in Flushing, Cornwall.
Trefusis Lodge is just outside the delightfully pretty waterside village of Flushing, across the Penryn River from bustling maritime Falmouth. This lovely semi-detached Victori...
7 nights from £458
7 nights from £355 *
Little Trefusis1199
2 bedroom, rural apartment near the beach in Flushing, Cornwall.
Little Trefusis is a single-storey cottage close to Flushing, a delightful waterside village with two popular pubs and a harbourside cafe. This charming cottage has an open plan li...
7 nights from £355 *
Need more time? Reserve any cottage for up to 24 hours before booking.
24hr no commitment reservations
You can reserve your holiday dates on your favourite cottage for up to 24 hours. You might need to check with other guests in your party or simply consider whether this cottage is right for your holiday, either way we're happy to give you the time to step away and mull over your options before paying a penny.
We'll send you a reminder to see if you want it or not so you won't lose out. Take time to think it over, you don't have to rush your decision. Have a cup of tea and when you're ready, hit the button to book your holiday and start looking forward to it.
7 nights from £475 *
Ocean Blue4234
3 bedroom, dog friendly cottage near the beach in Flushing, Cornwall.
A beautifully styled terraced house in the pretty village of Flushing, this is the ideal place for a fabulous holiday. There is plenty of space for everyone to enjoy time together ...
7 nights from £475 *
7 nights from £592 *
12 Trefusis Road4213
3 bedroom holiday cottage near the beach in Flushing, South Cornwall.
This delightful property is found down an Cornish ope in the gorgeous, waterside village of Flushing. The deceptively large cottage will have you saying 'wow!' as soon as you walk ...
7 nights from £592 *
7 nights from £640
Harriet Place4341
3 bedroom apartment with sea views in Falmouth, South Cornwall.
The enchanting views from this gorgeous apartment will mesmerise you, and you will feel your worries drift away with the ebbing tide at Harriet Place. Tucked away down a small path...
7 nights from £640
7 nights from £360 *
3 bedroom apartment with sea views in Falmouth, South Cornwall.
Superb views over the water to Flushing and the Roseland peninsula are guaranteed from this beautifully decorated contemporary first floor apartment, part of the renowned Admiral's...
7 nights from £360 *
7 nights from £537
2 bedroom apartment with sea views in Falmouth, South Cornwall.
Set right on the water and as near as you can get to being on a boat without leaving dry land, this is a wonderful holiday location. Whizziwig is a stylish and comfortable ground f...
7 nights from £537
7 nights from £798
3 bedroom, rural cottage with sea views near Truro, South Cornwall.
Glorious views and luxurious comfort will greet you at Trebartha, enjoy watching the ever-changing waters of Restronguet Creek in this tranquil spot. There is much to explore on bo...
7 nights from £798
Our property managers are local experts who handpick perfect places to stay.
Local experts
We scour the coast and country to winkle out bits worth sharing with you, the best properties in lovely locations. While we're out and about, we gather together the best things to do so that you can start planning your holiday as soon as you've booked.
The 'Explore Nearby' tab on our cottage pages show what's nearby along with relevant articles from our holiday guides from Notes and Stories, where you'll find hand-written experiences of outings across the South and West, from dog-friendly pubs on the Isle of Wight to free things to do in south Devon and everything in between.
7 nights from £537
Tall Ships374
2 bedroom apartment with sea views in Falmouth, South Cornwall.
There are fabulous views from this lovely waterside apartment, looking over to the pretty village of Flushing, the Roseland and beyond. Tall Ships is a wonderful base to explore Fa...
7 nights from £537
7 nights from £474
Pennant Cottage3996
2 bedroom holiday cottage with sea views in Falmouth, South Cornwall.
There are glorious, far reaching water views from every room in this beautifully appointed, modern cottage, stretching from the moorings on the Penryn River out across the Carrick ...
7 nights from £474