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Museumplein (Museum-square in English) is the name given to the area between Rijksmuseum and the Concertgebouw. The area got the name because of the museums located around the square and therefore also referred to as Museum Quarter or Museum District. The square has an extraordinary history and is unique to Amsterdam, just as it would be in any European city with its size. Situated close to the busy city centre, the Museumplein is where all tourists in Amsterdam converge.
The Museumplein is located in Amsterdam South, south of the Rijksmuseum. The square plays an important recreational function within the city. Due to the presence of large and smaller grass areas, a pond and other recreational options, the square has almost a park-like feel and appearance. All kinds of events are organized on the square, including the Uitmarkt. The Museumplein is also often the place where large demonstrations are held. In addition to the aforementioned Rijksmuseum, there is also the Stedelijk Museum, the Van Gogh Museum and the Concertgebouw on the Museumplein.
Almost all tourists in Amsterdam eventually end up on the Museumplein. Apart from the fact that three of the city's most popular museums in Amsterdam are located there, the square also has some canal cruise companies in the vicinity. There are trendy shops for shopaholics, cosy restaurants serving tasty dishes from all over the world and in the summer, lots of sporting activities are also organised on the square. The popular Leidseplein is also just a mere 5-minute walk from the Museumplein.
History of the Amsterdam Museumplein
Terrain for art and culture
The history of the Museumplein can be described as quite exciting. The square is located where the World Exhibition of 1883 was once held. In 1885 the square was given the name Museumplein because the Rijksmuseum Amsterdam came to be located there. In 1903 the name Museumplein became official. Until 1940 the Amsterdam Ice Skating Club also came to be located on the square.
The site where the Museumplein is located now used to be a farm until well into the nineteenth century. However, the Amsterdam board designated this region as an area for art and culture. The site was used in the winter as the ice rink of the city of Amsterdam. A number of international championships were organized on the 400-meter track at the end of the 19th century. Originally, some villas were built on the site with the Rijksmuseum as a gateway. The extra buildings on this side of the Rijksmuseum, such as the director's office and the library, were supposed to connect architecturally to the villas. Through a plea by the architect of the Rijksmuseum, Pierre Cuijpers, during the council meeting of December 2, 1891, the municipality finally decided in 1902 to leave a large part open and to build only a small part of the block of villas.
During WWII there were bunkers and barbed wires on the Museumplein. They were demolished from 1946 to 1953. Nowadays the Stedelijk Museum Amsterdam, the Van Gogh Museum and the Concertgebouw are also located on the Museumplein. The Leidseplein isn't very far away.
The Museumplein Today
The Museumplein got a new look at the end of the nineties. The wide street across the square disappeared and the Van Gogh Museum was given a new wing. A parking garage and a supermarket were built under the square. On the north side of the Museumplein are spacious houses from around 1900.
Since 1999 there has been a pond near the Rijksmuseum with terraces on both sides and a museum shop. Tourists use the square to rest from their cultural outings and as a meeting place for the bus that is parked somewhere below the square. Since the redesign of the square in 1999, the square no longer has the traffic function of before, there are only a few cycle paths running through it.
What's there to see around the Museumplein?
Over the decades, Amsterdammers and tourists have used the square every day to recreate and rest. Before the war, the site was popularly known as the IJsclub site but today, it is the Museumplein and one of Amsterdam's most popular squares. Even now, the grassy areas invite both residents and visitors to play football in the summer, Frisbee and picnic. Below are some of the most interesting places to visit while in the vicinity.
The Royal Concertgebouw Amsterdam
The Royal Concertgebouw came after a competition organized in 1881, in which the design by A.I. van Gendt (1835-1901) was chosen. The spacious concert hall in Amsterdam became a neo-Renaissance building with a richly decorated tympanum and a column facade. Two concert halls are hidden behind the column facade. The architect succeeded in giving the Great Hall perfect acoustics which the Concertgebouw is very proud of. The Royal Orchestra also performs regularly in the Great Hall.
Van Gogh Museum Amsterdam
Van Gogh Museum in Amsterdam This austere museum was built in 1973 for the work of the Dutch artist Vincent van Gogh. In addition to paintings and drawings that portray the career of Vincent van Gogh, the museum holds hundreds of letters from the painter to his brother Theo, and his collection of Japanese prints. The Vincent Van Gogh Museum also displays art from other 19th-century Dutch painters. In the extension of the Japanese architect Kisho Kurokawa, opened in 1999, temporary exhibitions are being organized.
The Stedelijk Museum Amsterdam
The Stedelijk Museum Amsterdam was built in 1895 to house the collection of Sophia de Bruyn. Since 1938, the museum has been the national museum for modern art and modern art in all its facets is showcased there. The museum's collection contains artworks by painters such as Henri Matisse and Wassily Kandinsky, with a heavy emphasis on paintings, drawings, images, videos and photos from after 1945.
House of Bols Amsterdam
House of Bols Amsterdam is the perfect attraction for tourists, especially those visiting for the first time. The House of Bols Amsterdam's best-known gin and liqueur brand has set up an Experience on the Museumplein that you will find very difficult to forget. The best thing is to combine a visit to House of Bols with a group of friends/acquaintances/colleagues with a culinary gin tasting or cocktail workshop. Don't miss out on this wonderful experience on the Museumplein.
Vondelpark Amsterdam
For many people in Amsterdam, the Vondelpark is the most popular city park in all of the Netherlands. The 1.5-kilometre long and 48-hectare national monument form an oasis of tranquillity in the hectic city centre. Until the mid-20th century, the park remained the property of private individuals but because the maintenance costs could no longer be paid the private individuals, it was donated to the city of Amsterdam. The park owes its name to the placement of a statue of writer/poet Joost van den Vondel (1582-1674). Vondelpark is fun because of the number of activities that takes place every summer in the park. It is also the ideal location for picnics and friends who want to hang out on the green grass during sunny days.
Moco Museum Amsterdam
The Amsterdam Moco Museum stands for Modern Contemporary Museum Amsterdam. This is a private museum for modern and contemporary art in the Amsterdam city centre. In the Moco Museum, visitors can see a wide range of modern, inspiring and contemporary art from artists such as Warhol, Banksy, Icy & Sot and Roy Lichtenstein. The Moco museum is aimed at showcasing the works of radical leaders and influencers of modern art movements, such as street and pop art. The Museum welcomes visitors of all ages. The artworks on display are inspired by graffiti such as that of Icy & Sot and Banksy or Roy Lichtenstein. It's a museum that attracts a lot of young people.
Diamond Museum Amsterdam
In the Amsterdam Diamond Museum, visitors make a journey that began 3 billion years ago and ends at the ring on your finger. View world-famous and rare diamonds from all over the world. The city of Amsterdam and diamond are inextricably linked and it's not possible to visit the city without finding out all there is o know about the history of the diamond trade in the city. The history of the diamond trade in Amsterdam began in 1586 and continues to this day. Nevertheless, the eventful history of the diamond is not equally familiar to everyone. The Diamond Museum Amsterdam reveals the stories behind the precious stones with films, jewellery, historical documents and of course diamonds. Get to know everything about the history of the Amsterdam diamond trade, see artisans at work, and stand in the room of mirrors – it's like being in the middle of a huge diamond here!
Sightseeing on the Canals
Discovering Amsterdam from the canals still remains the best and most appropriate way to see all the sights and beauty of the city. Hop on one of the canal boats ay you let the beauty of centuries-old canal houses pass you by and at the same time you avoid the hectic pace of today's Amsterdam, especially in the summer. Most cruises depart from the Leidseplein and just across the street from the entrance of the Vondelpark.
The Heineken Experience Amsterdam
The Heineken Experience is located in the first Heineken brewery in the heart of Amsterdam. It isn't very far from the Museumplein. The brewery was closed in 1988 because the production capacity could no longer meet the high demand. Since 1991, the brewery has welcomed visitors from all over the world. The Tour of the facility is an independent interactive journey through the world of Heineken. Visitors discover the history of the HEINEKEN company, the four natural ingredients of their beer, the brewing process, a tasting, the Heineken brand and the partnerships with the UEFA Champions League and Rugby World Cup. At the end of the tour, you can, of course, enjoy two glasses of Heineken or learn how to tap a perfect glass of Heineken. Visitors under the age of 18 must be accompanied by an adult and according to Dutch law and Heineken policy, no alcoholic beverages are served to visitors under the age of 18.
How to get to the Museumplein by public transport
The Museumplein is located in the centre of the city. Public transport is the best way to get to the Square. Visitors can also walk to the square because of its central location.
1079 RA Amsterdam
The Netherlands.
From Amsterdam Central Station
Trams 2, and 12: Exit at the stop "Rijksmuseum". and from there it's a two-minute walk into the park.
For real-time travel information from wherever you are to the Vondelpark, please check out this link;
Museumplein on the City Map
Parking Around The Museumplein
On the Museumplein, in the Amsterdam Center district are three of the city's largest museums, the Stedelijk Museum, the Van Gogh Museum and the Rijksmuseum. The Concertgebouw also overlooks the Museumplein and the Vondelpark is within walking distance. Street parking is almost impossible around the museum square. A parking garage is a better option. However, public transport still remains the best way to visit the Museumplein because parking can be very expensive in Amsterdam.
For a visit to the Museumplein, you can use the following parking lots:
Museumplein Amsterdam Parking – Parking capacity on the street can be very scarce in this area. There is often still a place to be found around Laisessestraat and Koninginneweg. Compared to some parking garages around the museum square, this can be a cheaper option.
Vondelpark Parking – Vondelpark is adjacent to the 'Zuid district' on the South side of Amsterdam and the 'West district' on the North side of the city.
Paid parking is available on the South side of the Vondelpark on the following days:
Monday – Saturday – 09.00-24.00. The tariff on the Southside is € 4.00 per hour.
There's paid parking in the Westside on the following days:
Monday – Saturday – 09.00-24.00. The tariff on the Westside is € 3.00 per hour.
Q-Park Museumplein – This parking lot is located under the museum square at the Albert Heijn. The parking lot is spacious with no less than 600 spots. Parking fees can be quite high and can go for more than € 6.00 per hour.
Q-Park Byzantium – This parking lot is right around the corner from the Vondelpark (around the corner of the PC Hooftstraat). Parking fees can be quite high and can go for more than € 6.00 per hour.
Parking Garage Bee Overtoom – Very cheap parking garage near the Overtoom and Vondelpark. You can easily walk to the Museumplein or Leidseplein from here. You can only drive in and out and pay with your mobile phone via the free downloadable app from Parkmobile.
Museumplein on the City Map
Interesting Facts About the Museumplein Amsterdam
With over 10 million annual visitors, the Museumplein is the biggest and most visited part of Amsterdam, and also in the Netherlands. The huge expanse of land with its lovely atmosphere has made the most popular square in the Netherlands and an ideal place for both Amsterdam residents and visitors to go for leisure time activities like picnics and summertime football. Below are some of the interesting facts about the Museumplein.
- The site where the Museumplein is now located used to be home to a few farms until the beginning of the nineteenth century when the municipality decided to make it a site for culture, art and leisure time activities.
- Just a few meters from the Museumplein is the Vondelpark is named after Amsterdam's best-known poet, Joost van den Vondel (1587-1679). A statue of him also stands in the park.
- In 1881, a competition for the best design of a communal building was held and A.I van Gendt's design was chosen. That design came to be the Amsterdam Concertgebouw that we all know and love today.
- The Museumplein was reconstructed after a design by the Swedish/Danish landscape architect Sven-Ingvar Andersson in 1999. It now includes underground parking spaces and an underground supermarket. In the winter, the pond can be transformed into a series of artificial ice skating rinks.
- There used to be bunkers and barbed wires on the Museumplein during WWII. They were only demolished in 1946, and completely in 1953.
- On November 21, 1981, one of the largest demonstrations in Dutch history took place on the Museumplein: 420,000 people demonstrated against the placement of new nuclear weapons in Europe.
Are you interested to take a look at other places for a day trip in the Netherlands? We made an overview of the very best places for a day trip while you're visiting Holland.
Rijksmuseum Amsterdam
Discover everything about the world-famous museum and all the priceless artworks in it.
Van Gogh Museum Amsterdam
Pay a visit to one of Amsterdam's most famous museums dedicated to the Dutch Master, Vincent van Gogh.


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Solution Manual for Economics: Canada in the Global Environment, 8/E 8th Edition : 321808398 Textbook PDF [Alani Diaz Learn More Here]
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I've modified the 'Xamarin_Data_Complete' project from XAM160 (old version). Right now I'm testing it with large XML files. If I update, search and display the data I get a
SQLite.Net.SQLiteException: Busy
I can solve this by catching this exception and try again 1 second later. Is this the right approach or should this exception never happen under 'normal' conditions?
In the past I only used CoreData with a Sqlite backend. To persist the data on disk you had to call save explicitly. I didn't find something similar in this project. Is the save always done automatically and never in control of the user?
The last thing I'm searching a solution for is the Linq expression to search the database.
This is the Linq expression from XAM160
return await Table().Where(s => s.Id == id).FirstOrDefaultAsync().ConfigureAwait(false);
I try to modify it to be able to search for more complex search string like:
string searchThis = "text1 text2 text3"
searchThis should be used for a full text search which means every part of the string should be handled separately.
The search parts are separated by a space and I can do
List searchAllTheseParts = searchThis(new string[] { " " }, StringSplitOptions.None);
Can I use Linq for this approach or is Linq the wrong answer for this kind of search and I have to go back to SQL?
This modification doesn't work:
return await Table().Where(s => s.MyField.Contains(searchAllTheseParts[0]) && s.MyField.Contains(searchAllTheseParts[1]) && s.MyField.Contains(searchAllTheseParts[2])).ToList().ConfigureAwait(false);
Can you give us access to the project so we would be able to try it?
Hello Rene,
I've attached the sample project. Right now I get a database locked exception and it looks like because of the inserts I'm doing.
After modifying the xam sample project there are some questions that came across:
Is my solution for a background database update, insert and delete the right approach? Should I just use some try / error statements to react on the 'database busy', 'database locked', … exceptions and just try again?
I'm looking for a performant full text cross platform search function. Right now I'm putting all the content of the tables in one ContentString field and do a Linq search on it.
But my approach feels really bad right now. If you type in letters the previous search should be canceled first. Is this possible with a Linq expression?
Second problem is the results come in too slow. I've played around with the Take() and Skip() functions to get results faster. It works but I hope you could lead me to some other better approaches?
I have just seen your reply here @JuergenK - I will have a look at your solution tomorrow.
As for fulltext search: I have never tried or implemented this. But it seems to involve quite some work. Here's something that might help you. http://stackoverflow.com/questions/5372409/how-to-use-fts-in-sqlite-with-monotouch-for-ios
And here's something that is a reply to a question I asked myself long ago. I wanted to use SQLCipher and combine that with fulltext search. The Gist contains the reply. I have never tried or evaluated the code. But if it works with SQLCipher, it should work with Sqlite too: https://gist.github.com/developernotes/5311963
I looked at your project. I see three issues.
DollyMaker<T>()- why do you clone the sessions? Just reuse the instances.
The problem with the locked DB however is caused by
private async Task DataImportEditUpdateWorker()
This method runs async. If you search the DB, it might be locked since the method above is still inserting. If you wait until this method has finished, your code will work.
And last: you are creating ten thousands of session objects in that method. This causes the Java Garbage Collector to freak out on my machine and I presume on a device it would just crash. If I change the for loop to only create 10 instances of 10000 it will still take a while for it to finish but it won't run OOM.
The DataImportEditUpdateWorker() is just for a simulation of a background update, insert, ... process - maybe a too lazy one. ;-)
That means a correct approach would be a global variable for example
searchRunning = true
before starting the search and pause the background update process until the search has finished to avoid the DB exceptions?
I see what you are doing there...could it be that you are running into this problem: https://github.com/oysteinkrog/SQLite.Net-PCL/issues/42
Maybe you want to submit an issue to the SQLite-Net PCL project and provide them with your example.
Thanks Rene, that's exactly the issue. I try to modify my project to build it more OOM friendly and try the solution they provide!
@JuergenK Would you mind sharing your solution when you're done? I presume you will use a singleton for
SQLiteConnectionWithLock. I think it will help other users if they find a solution here in the forum.
Hello Rene, yes definitely. But it will take some time because I'm a bit busy right now and need to find solutions for some other questions right now.
For a quick check I've removed the
new SQLite.Net.SQLiteConnectionWithLock
and put it into the constructor. Now it's called only once but the SQLite.Net.SQLiteException: Busy crashes still occur. I've add a record counter to see how many records are in the db right now. On my slow Motorola device the crashes start happening after 1000 records after you keep searching through the database.
After that I've added a second SQLiteConnectionWithLock in the sample project (DataManager2) and use this for the background db record insert and update (IncreaseDatabaseSize). I was hoping a SQLiteConnectionWithLock that's only used for the search and another that's only used for the background update and insert would solve the problem. But it doesn't.
If there is a need for deeper investigation for example on GitHub like Rene mentioned
can I use the sample project which is based on the Xamarin University sample to publish it on this public forum?
The sample project is here:


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Market Study Report adds Global Methyl Hydroxyethyl Cellulose (MHEC) Market 2019 Report to its research database. The report provides information on Industry Trends, Demand, Top Manufacturers, product, revenue (value) and end users/applications.
The latest market report on Methyl Hydroxyethyl Cellulose (MHEC) market offers an in-depth analysis of this business vertical involving key information concerning industry deliverables, predominantly market tendencies, market size, market share, present valuation, and profits estimations for the estimate period. The brief information regarding the industry also analyzes and elucidates the Methyl Hydroxyethyl Cellulose (MHEC) market growth rate in the forecast timeline, incited by certain catalysts, a gist of which has been provided in this research report in conjunction with the first challenges and growth prospects present within the industry.
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Market Growth by Types:
Pharma Grade MHEC
Food Grade MHEC
Industrial Grade MHEC
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Paint and Coating
Personal Care
Food & Beverages
Global Methyl Hydroxyethyl Cellulose (MHEC) Market 2019 Highlights:
The Methyl Hydroxyethyl Cellulose (MHEC) market has been performing vigorously at both the national and international levels for the last decade with a steady CAGR. It is expected to exhibit commendable growth to 2025 as growth in the market is being fostered by technology, innovation, product awareness, rapidly increasing demand, and rising disposable incomes. The market also holds the potential to influence the international economic structure with considerable revenue in the near future.
Strategic Points Covered in TOC:
Chapter 1: Introduction, market driving force product scope, market risk, market overview, and market opportunities of the global Methyl Hydroxyethyl Cellulose (MHEC) market.
Chapter 2: Evaluating the leading manufacturers of the global Methyl Hydroxyethyl Cellulose (MHEC) market which consists of its revenue, sales, and price of the products.
Chapter 3: Displaying the competitive nature among key manufacturers, with market share, revenue, and sales.
Chapter 4: Presenting global Methyl Hydroxyethyl Cellulose (MHEC) market by regions, market share and with revenue and sales for the projected period.
Chapter 5, 6, 7, 8 and 9: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries in these various regions.


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Tag Archives: interleukin 1 receptor antagonist
Cytokine signatures in CFS patients: a Case Control Study & the effect of anakinra treatment
Research abstract: Cytokine signatures in chronic fatigue syndrome patients: a Case Control Study and the effect of anakinra treatment, by Megan E. Roerink, Hans Knoop, Luuk J. A. C. Hawinkels, Leo A. B. Joosten and Jos W. M. van der Meer in Journal of Translational Medicine 2017 15:267 Background: Cytokine disturbances have been suggested to be associated with the Chronic … Continue reading
Cytokine inhibition in CFS
Research abstract: Background: Interleukin-1 (IL-1), an important proinflammatory cytokine, is suspected to play a role in chronic fatigue syndrome (CFS). Objective: To evaluate the effect of subcutaneous anakinra versus placebo on fatigue severity in female patients with CFS. Design: Randomized, … Continue reading


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The Ultimate Evolution - Volume 5 - Chapter 4
Chapter 4: You're stronger than him!
Translated by: CHua
Edited by: XRCO and Elkassar
The next person that left a deep impression on him, was the woman 'Tulip' that spoke out at the start. She had extraordinarily good looks, yet her manner of speech was emanating great shrewdness and experience;an orderly HR style of a typical multinational company. Her charm was currently 25 points, and could engage in interactions with most storyline characters. Her summoned creature was an huge Alaskan bear, and simultaneously release long distance combat assistance.
When Mogensha stood out to introduce himself, Sheyan had noticed that Qiaoer and Harnik frowned to each other;as if understanding a common enemy. Naturally Mogensha's appearance had caused them some pressure. Crazy Harnik couldn't help inquiring.
''Mogensha you betrayed the Symbiosis sect;aren't you afraid the Metals professor will slaughter his way in?''
Obviously crazy Harnik purposely tried to sneak in a blow towards Mogensha to suppress his position amidst the party. Instead, Mogensha wasn't interested to bother with reporting to him, he merely shot a stiff look before sitting down while hugging his gun.
At this point in time, only Sheyan and another was left. That guy hadn't spoken up once since the cabin, constantly hanging his head down as though he had suffered some calamitous setback. Sheyan had decided to go last, hence he firmly gazed towards the ceiling;while the decadent male was fixated on the ground. Slowly, he walked out. His movement was like a rumbling tank, slowly releasing his hollow voice.
''I am Reef, party position - Close combat defender.''
''Close combat defender.'' The instance this word left his lips, it was greeted by a series of gasps!! One must understand, those who were willing to say those words were similar to the likes of Qiao Gun;signifying he would hold the frontlines in a battle! It couldn't be false, because a lie would indicate joking around with his life.
Crazy Harnik and Qiaoer's faces turned uglier. Those who had already experienced several worlds before deeply understood the importance of a close combat defender. Which goes to say - if this Reef guy wanted to challenge for the party leadership, then they would no doubt be at a disadvantage!
Following on, the next things Reef mentioned added fuel to crazy Harnik and Qiaoer's despair! Because the ability that Reef divulged was actually his innate ability!!
A-grade Innate ability!!!!
'Steel': Reduction in damage received by 22%, causing abnormal debuff durations to reduce by 50%.
He was actually similar to Sheyan, having a defensive type innate ability. A mighty contestant!
Seeing this genius talent, crazy Harnik and Qiaoer immediately discarded whatever ambitions they had in their heart. They shifted their focus on how they could enhance their authority within the party. Such a contestant was an unparalleled freak who are hailed as MTs (Main-tank Core master tanks);he would certainly become a core existence in the party, unless he opted out of it himself. But who would give up the grand position as a party leader?
''A grade innate ability!!'' Sheyan's heart welled up with an unfathomable confusion, filled with envy, disappointment and dejection. But he immediately suppressed his emotions. Mogensha had long been observing Sheyan;seeing his unchanging expression, he admired him secretly. He then issued a message through his nightmare imprint.
''Seaman, don't be unduly humble. Actually based on your innate ability itself, you are much stronger than him.''
Sheyan didn't expect Mogensha to offer him this consolation, surprised he replied.
''How is that so?''
Mogensha who had an extensive knowledge, grinned and replied.
''This thing called innate ability, is not something that can get stronger by its grade. Reef's innate ability seems pretty formidable, but it's grade is already A-. Any further upgrade is unlikely. Let's not talk about A- upgrading to S grade. Even for a B grade to A, the requirements are extremely demanding. To upgrade one not only requires hardwork, risk and and huge amount of time, it even requires luck! Let's cite a simple example - If the metals professor trying to steal the philosopher's stone is considered 1 difficulty, then reef's innate ability trying to raise from a to s is at least 2.5 difficulty!''
Until here, Sheyan had roughly understood Mogensha's theory, yet Mogensha continued speaking.
''For you, primarily your innate ability had not yet been awakened in the present world. Once it awakens, your innate ability will receive a further improvement. Following that, you can still raise it from C+ to B+, then B+ to A+, two entire upgrades in strength! Calculating, you will have a frightening 3 times upgrading chance!! Hence once you reach Reef's level, your innate ability will definitely vastly exceed his! Furthermore you who was able to take down both the Metals professor and Fanu, I believe that Reef's current aptitude now is only a short term problem.''
Sheyan's lips slightly curved up, his heart's residual concern had been appeased by Mogensha's words. In his heart, he recalled the incident regarding the winged keys in the Harry Potter world.
''Winged keys attack disregards any defence, its attribute possess the domain precedence.....''
''Conflict surfaces, determining precedence......''
''Determining results: Your innate ability: 'Endurance' takes precedence!!!''
''Even a domain precedence property couldn't go against an innate ability.... It actually still contains 3 upgrading opportunities, what kind of surprises would you delight me in?''
Concurrently, when everyone was being shakened by Reef, Tulip exclaimed in astonishment.
''Reef????!'' Why would you have abandoned your party? Didn't your 'Sphere' party already complete the history storyline war in Pirates of the Caribbean! Even your party has expanded to 40 strong!''
Reef bitterly shook his head saying, ''There's no more 'Sphere' in the world anymore.'' He then returned to his earlier dejected state and remained silent. Qiaoer's eyes leaked out a wild overjoyous expression. Obviously, even if Reef's ability was outstanding, without any fighting spirit, it was totally useless. Hence, Qiaoer took the initiative and spoke out.
''Very good, our temporary party actually possessed such luck. There's actually a MT, since everyone has introduces, likes decide on our next course of action.''
Tulip snatched to speak next.
''I will mingle with the storyline characters, let's see if I can gather any hidden information.''
Crazy Harnik nodded and replied.
''Based on my experience, the military occasionally possess some one-off off props or even sell certain weapons. But since the commander of this base doesn't have a favourable impression of us, we have to first increase our reputation from 'cold' to 'amiable' before being able to purchase anything.''
The remaining people all competed to chip in their ideas.
Suddenly, the dejected Reef by the side interrupted them coldly.
''There's still one more who hasn't introduced himself.''
Although Reef didn't seem like he bothered to participate in the decision making, his words carried a decisive tone and weren't something the rest could neglect! The people speaking were stunned, their faces exposed their awkwardness. Amidst their excitement of having a mighty close combat defender like Reef joining the party, they actually forgotten Sheyan..... It can be seen that Sheyan didn't really have a presence with his low profile.
Similarly, even Mogensha was curious what manner would this 'Seaman' introduce himself with. He was convinced that this 'Seaman' style was a low-key tiger that disguised as a pig. The fearsome Metals professor and Fanu most likely fell short because of that. Hence he knew Sheyan wouldn't be one who would publicly announce his status, yet hiding his true potential excessively would demote him to the tail of the pack. He could even be abandoned by the party. Yet if he elevated himself too highly, it didn't suit his style. Facing such a difficult option, what path would this 'Seaman' take?
At present, Sheyan had already stood out, firmly and calmly introducing.
''I am Seaman, nice to meet y'all. My party position is: Battle support. Additionally a strength type close range combatant.''
The bunch were rather amazed to hear Sheyan's introduction, which also included Mogensha. Because in their eyes, it was mostly intelligence or spirit based contestants who provided support in a battle. Henrik was exactly that type. Instead Sheyan who hailed himself as a strength type close combatant who could provide support was really a unique unprecedented individual.
Under the suspicious gaze of the audience, Sheyan very composedly explained the 3 'Uruk-hai gene fluids' out to them. It was instantly greeted with a series of gasps. One must understand, these contestants previously belonged to a party- this signified their difficulty in passing through worlds would be lessened, but also meant a shortage of equipment for themselves!
Sheyan's 'Strength of the bear's flesh mix' could already enhance 3 points of strength, this was equivalent to a bonus from a dark blue class equipment! Sheyan's 'Rotten bone ring' only increased Strength/physique +1 and could already be considered a high quality equipment. To an incredible 30 points strength contestant, the enhancement would be an entire 10%. Moreover, how many people could even achieve 30 points in strength?


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77 // Is It Okay To Be Low Vibe? My New Favourite Crystals
In this episode, I get real and raw about:
· Having a low vibe day
· Actually recording this on a low vibe day
· Whether it's okay to be low vibe
· What I do to get out of being low vibe
· My new favourite crystals
♡ // Join Manifestation Monthly HERE!
♡ // To check out 1-1 manifestation coaching with Kimberley, click HERE.
♡ // Get the password to download the Modern Girl Manifestation Routine ebook from the KW resource library HERE!
♡ // To READ more about The Manifestation Collective click HERE!
♡ // To join The Daily Manifestation Facebook Group, join HERE!
Instagram: @kimberleywenya


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Based on the Eurostat gender pay gap definition, the gender pay gap in Austria was 22.2% in 2014, compared to 25.5% in 2006, according to a study conducted by Statistics Austria in the year 2017. This is considerably higher than the EU average of 16.7% (2014), albeit coupled with a relatively high female employment rate of 66.9% (2014).
The most significant observed cause for the gender pay gap in Austria is the segregation of the labour market in terms of business sectors: a considerable number of women work in lower paid roles and sectors (such as retail). Along with a number of other characteristics such as education, age, seniority, full and part-time employment and - to a lesser extent- region and size of enterprise, roughly one third of the gender pay gap can be ascribed to structural differences. While the remaining two thirds might be attributable to gender discrimination, unobserved factors (such as admission and promotion requirements) may equally play a role.
Significantly more women are employed on a part-time basis. The number of women employed on a fixed-term basis is slightly higher than that of men. Both factors however tend to be more detrimental to men's earnings than they are to women's.
Please click here to read the full article.
Alle Angaben auf dieser Website dienen nur der Erstinformation und können keine rechtliche oder sonstige Beratung sein oder ersetzen. Daher übernehmen wir keine Haftung für allfälligen Schadenersatz.
The material contained in this website is provided for general information purposes only and does not constitute legal or other professional advice. We accept no responsibility for loss which may arise from reliance on information contained on this site.


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Sherpa Collar Military Jacket
Style: 7W30985 Final Sale
Additional Information
Defined by its throwback sherpa collar and boxy construction, our durable cotton military jacket features structured patch pockets, button closures, adjustable side tabs and long sleeves with buttoned cuffs.
- Sleeve length measures from center back to sleeve end.
- Length: 23.5 inches, Sleeve length: 31.5 inches (Size small)
Fabric & Care
97% COTTON 3% LYCRA Hand Wash Cold IMPORTED
Customer Reviews
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Ashley 3/15/18
It's a little smaller on the arms but not a dealbreaker.
Cute and comfy
Kayla 3/10/18
Although the sherpa only lines the collar, it makes a big difference in how warm it is! Another thing that I didn't realize about this jacket is that the sherpa lining can be removed if you'd like.
so cute
Barbara 3/2/18
It's a nice light, well made jacket.
Love this jacket
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Tuesday, 24 February 2015
spring is just around the corner...
All the signs are here - snowdrops, lambs everywhere and the days are getting noticeably longer. But the absolute giveaway is the smiling - there's a lot of it about, and it's LOVELY!
Tuesday, 3 February 2015
Valentine's day leather workshop - better than a bunch of forecourt flowers!
Stuck for ideas this year? Give the gift of time off from the kids and the opportunity to make a beautiful bag in one of our leather workshops. There's even one on Valentine's day itself!
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The MINT try-out-days in Penzberg
Between March 30th and April 10th 2015 we are welcoming 150 students at our site in Penzberg who are able to try out different jobs within our job branch. The students are from partner schools in the surrounding of Penzberg.
Usually they are in educational training for the following professions:
- biological laboratory assistant
- chemical laboratory assistant
- chemical technician
- electronics engineer for automation
- electronics engineer for operating technology
management assistant for office management
We wish our participants an exciting and successful time at Roche!
For further information about Roche as an employer and entrance possibilities, please visit our careers page http://www.roche.com/de/careers/jobs.htm .


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At Two Fields Design we create vibrant wall hanging sculptures and collages for hotels, hospitals, and other private spaces.
We work with designers to create one-of-a-kind pieces, often in large editions, to fit any scale of project.
Get in touch at firstname.lastname@example.com
Large wall hanging created from recycled wood (7 x 10')
See LucyHoltsnider.com and @lholtsnider for additional inspiration!
Located at the corner of Whinfield and Delafield streets in Poughkeepsie, New York.


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Penguins score seven for second straight night in win against Jets
WINNIPEG -- Sam Lafferty, Jake Guentzel and Zach Aston-Reese each scored two goals, and the Pittsburgh Penguins won their third-straight game with a 7-2 win against the Winnipeg Jets at Bell MTS Place on Sunday.
The Penguins scored seven goals for the second straight game and third time time this season, defeating the Minnesota Wild 7-4 on Saturday and the Blue Jackets 7-2 on Oct. 5.
Aston-Reese also had an assist and Sidney Crosby had two assists for the Penguins (4-2-0). Lafferty has five points (three goals, two assists) in his last two games for the Penguins.
Kris Letang had two assists to put him at 501 points in the NHL, extending his point streak to six games (one goal, seven assists), and Tristan Jarry made 27 saves in his first start of the season for Pittsburgh. Crosby also extended his point streak to six (three goals, seven assists).
Mathieu Perreault and Mark Scheifele scored, and Laurent Brossoit made 21 saves for the Jets (4-3-0), who lost for the first time in four games.
Perreault scored 1:47 into the game to give the Jets a 1-0 lead.
Aston-Reese found a loose puck on the side of the net to tie the game 1-1 4:09 into the first period.
Guentzel's power-play goal at 7:50 of the second period put Pittsburgh ahead 2-1.
Lafferty made it 3-1 Pittsburgh 41 seconds later at 8:31, with Letang getting the secondary assist to reach 500 NHL points.
Scheifele scored on the power play to bring the Jets within 3-2 at 10:00 of the second period.
Dominik Simon made it 4-2 Pittsburgh at 16:28 of the second.
Lafferty scored his second goal of the game at 9:13 of the third period to make it 5-2.
Guentzel made it 6-2 at 11:40 of the third period.
Aston-Reese scored shorthanded on a breakaway to make it 7-2 at 14:46 of the third.
Related News
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Sam Lafferty, Jake Guentzel and Zach Aston-Reese each scored twice as the Pittsburgh Penguins won their third game in a row, defeating the host Winnipeg Jets 7-2 Sunday. Dominik Simon also scored for the
'Thursday Night Football' Ratings Score With Seahawks' Win Over Rams
The Seattle Seahawks fought hard for their 30-29 victory over the Los Angeles Rams last night in what was a thriller of . A solid West Coast representation for the NFL, the second week
Indians go for 17th straight win against Tigers Thursday night
CLEVELAND - Forget about taming the Tigers, the Cleveland Indians have dominated Detroit this year and Thursday night they go for their 17th straight win over the team. A win tonight would tie the Indians
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Lafferty Gets 2, Penguins Youth Grounds Winnipeg Jets 7-2
The Pittsburgh Penguins 25 and under club provided the spark on the second of back-to-back games and brought the offense, too. Sam Lafferty scored the goal which held as the game-winner midway through the second
Canucks Extra: Boeser busts out
The Canucks ground out a win on Saturday night and Brock Boeser got his first goal of the season. It was a hard summer for Brock Boeser. And there was light at the end of the tunnel. His
New-look Canucks finding ways to win that they didn't last season - Sportsnet.ca
Iain MacIntyre |@imacSportsnet VANCOUVER - No team in the National Hockey League lost more one-goal games last season than the Vancouver Canucks. It's a simple and sometimes delusional thing to revise history, but if the Canucks,
Flames stage Vegas-worthy disappearing act against Golden Knights - Sportsnet.ca
Eric Francis |@EricFrancis Eric [email protected] LAS VEGAS - Mere metres from a strip where the likes of Criss Angel, David Copperfield and Penn & Teller have performed endless illusions, the Calgary Flames staged one of
Canucks top Flyers in shootout, deny Hart third straight victory
VANCOUVER -- Carter Hart's bid to become the first goalie in NHL history 21 years old or younger to win his team's first three games of a season fell short in a 3-2 shootout loss


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Longtime Encinitas businessman Myron Mueller passed away lastweek at the age of 74 while hiking in the mountains near PalmSprings.
Many of you will recall me telling you about Myron's bicycletravels over the past several years. Four years ago, he and fellowcyclist Jim Stout traversed the perimeter of the United States on abicycle journey that took them some 12,100 miles in 291 days.
Myron and Jim began their cycling journey Jan. 14, 2002, leavingEncinitas and heading east along the southern border. They rodetheir bikes to the East Coast, then north to the Canadian border,and back west to the Pacific Coast, then south, returning toEncinitas.
Their cycling trip was entered into the Guinness Book of WorldRecords as the oldest person to bicycle around the perimeter of theUnited States.
But Myron didn't stop there. Over the past seven years, he'sridden around Taiwan, New Zealand and portions of Australia.
"For those who knew him, he was the picture of health," saysdaughter Denise Mueller Boever.
Myron founded Rancho Santa Fe Security in 1978, beginning withjust one client. Today, the company serves many communitiesthroughout the north coastal region of San Diego County.
Myron went on his last outing April 3, for a few days of hiking.He began hiking the North Lykken Trail on April 4, but the weatherturned bad while he was on the trail. Myron took shelter just offthe trail under a bush near the 4,100-foot level. According toreports, he died while waiting for the storm to pass.
There will be a viewing for Myron from 2 to 4 p.m. Thursday atthe El Camino Memorial, 340 Melrose Drive in Encinitas, followed bya "Celebration of Life" at 4 p.m. at the Encinitas Cafe, 531 S.Coast Highway 101 in Encinitas.
Myron is survived by Denise, her husband, Ron Boever, threegrandchildren, Jonathan, Michael and Daniel, and fourstepchildren.
FILM GEMS -- Old-time film buffs won't want to miss the SanDiego Film Commission's free photographic exhibit all this month atthe historical Rancho Buena Vista Adobe in Vista. The photographsare the collection of Margarita Fischer Pollard, a silent-film starwho appeared in a number of movies shot in San Diego locationsbetween 1915 and 1917. She was the wife of MGM director HarryPollard. The Pollards lived in the adobe from the 1930s to the1950s. Many of the photographs are from locations such as the Hoteldel Coronado, La Jolla, Mission Valley, Sunset Cliffs, Balboa Parkand Lakeside. Adobe Gallery hours are 10 a.m. to 3 p.m., Wednesdaysthrough Saturdays. Call (760) 639-6164.
Notes for Tom Morrow can be e-mailed firstname.lastname@example.com, email@example.com. Find hisprevious columns on the Internet at www.nctimes.com.


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Posted by Pastor Mike on August 12, 2015, 11:03 am
Dear Heavenly Father, I desire to do as your Word instructs, and let "no corrupt word proceed from my mouth, but only what is good for necessary edification, that it may impart grace to the hearers." I do not want to "grieve the Holy Spirit, by whom I was sealed for the day of redemption." I pray that I will "let all bitterness, wrath, anger, clamor, and evil speaking be put away from me. And I want to be kind to one another, tender-hearted, forgiving one another, even as you in Christ Jesus forgave me. Oh that I would always be an imitator of you as a dear child. May I walk in love, as a child of light, finding what is acceptable to you." Please forgive me of my failures in these areas and help me to do better. I want to please you and be more like Jesus. Thank you in the name of Jesus, amen.
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Today's Prayer - Aug 12th - Pastor Mike August 12, 2015, 11:03 am
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Original article
Quality of Life, Fatigue, and Sleep Problems in Pancreatic Cancer Patients: A Randomized Trial on the Effects of Exercise
A randomized trial on the effects of exercise
; ; ; ; ; ; ; ;
Background: Improving quality of life (QoL) is an important treatment goal in pancreatic cancer patients. Although the beneficial effects of exercise on QoL are well understood, few studies have investigated more aggressive cancers such as pancreatic cancer.
Methods: Within a randomized trial, we assessed the efficacy of 6-month resistance training on physical functioning (primary outcome) and further QoL-related outcomes. 65 pancreatic cancer patients were assigned to home-based training, supervised training, or a usual care control group. Analysis-of-covariance models on changes from baseline to 6 and 3 months were applied.
Results: 47 patients completed the intervention period. After 6 months, no effects of resistance training were observed. However, after 3 months, explorative analyses showed significant between-group mean differences (MD) in favor for resistance training for physical functioning (pooled group: MD=11.0; p=0.016; effect size[ES]=0.31), as well as for global QoL (MD=12.1; p=0.016; effect size=0.56), and other outcomes, such as sleep problems and fatigue. Multiple imputation analyses yielded similar results. Home-based and supervised training performed similarly.
Conclusion: This first randomized resistance training trial in pancreatic cancer patients indicated clinically relevant improvements in QoL after 3 but not after 6 months. Given the severity of pancreatic cancer, exercise recommendations may already commence at surgery.
Pancreatic cancer is characterized by aggressive tumor growth with early metastases (1, 2). Further, cancer cachexia and sarcopenia are both ubiquitous characteristics which limit the ability to perform daily activities, compromise patients' quality of life (QoL), and have been associated with poor overall survival (3, 4). Therefore, preservation of physical functioning and health-related QoL are the main treatment goals of supportive cancer care.
Patient QoLvaries significantly depending on stage of disease and treatment phase. Thus, patients in a metastatic disease situation were found to have a lower QoL compared to surgically treated patients (5). Furthermore, patients shortly after surgery have a lower QoL than patients at two months after surgery (6). In the further course—three to six months postoperatively—the patients' QoL seems to stabilize (7, 8).
Physical activity plays an important role in supportive cancer care, as it has positive effects on physical and psychological well-being, both during and after cancer therapy (9). However, most studies on this topic investigated patients in an early stage of the disease, with less aggressive tumors and with a lower symptom burden. Studies including patients with more aggressive or advanced cancers are rare and most of them were conducted with small sample sizes and mixed entities (10, 11).
To date, only two randomized controlled trials (RCTs) have been published on exercise and QoL in pancreatic cancer patients (12, 13). A 6-week multimodal intervention (nutritional counseling, aerobic and resistance training, anti-inflammatory medication) in inoperable pancreatic cancer patients (n=20) observed no significant differences for fatigue and physical fitness (12). The second RCT conducted a 3-month home-based walking program among 102 pancreatic cancer patients (13). Although the intervention group improved with respect to fatigue, physical functioning, and QoL between-group comparisons did not reach significance.
The aim of the current study was to investigate the effects of a 6-month resistance training intervention on QoL and fatigue in pancreatic cancer patients. We hypothesized that patients who regularly perform resistance training experience better QoL, better physical functioning, fewer disease-related symptoms, and lower levels of fatigue.
Study design
Our study, the SUPPORT (Supervised Progressive Resistance Training for Pancreatic Cancer Patients) trial, is a three-arm exercise RCT comparing a supervised progressive resistance training group (RT1), a home-based progressive resistance training group (RT2), and a usual care control group (CON) over a 6-month intervention period. The primary outcome was the subscale physical functioning of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC) core module (C30) (14) at 6 months.
The study was approved by the Ethics Committee of the Medical Faculty of Heidelberg University (S-409/2013) and has been registered on ClinicalTrials.gov (NCT01977066). Trials were conducted in accordance with the Declaration of Helsinki and International Council for Harmonization guidelines for good clinical practice. All patients provided written informed consent.
Participants were recruited between December 2013 and December 2015. The inclusion criteria were: resectable or non-resectable pancreatic cancer (stage I-IV); mostly treated at Heidelberg University Hospital or National Center for Tumor Diseases in Heidelberg; age ≥18 years and sufficient German language skills.
As they received identical treatment regimes, patients with adenocarcinoma of the distal bile duct (pancreatic biliary) and with ampullary ductal adenocarcinoma were also eligible. Patients were excluded from the study if they showed insufficient wound healing, impaired hematological capacity (either hemoglobin value <8g/dl or thrombocytes <50 000), heart failure or uncertain arrhythmia, uncontrolled hypertension, severe renal dysfunction (glomerular filtration rate <30%, creatinine >3mg/dl), reduced standing or walking ability, or any other comorbidities, that precluded their participation.
Patients living close to the study center (about <20 km) were randomized to RT1 or CON, while patients living further away were randomly assigned to RT2 or CON. A 2:1 block randomization, stratified by sex and age, with a random number generator and varying block sizes of 3 and 6 was used. Randomization of a patient was done by an independent biometrician according to the pre-specified allocation list.
Outcome measures were collected via self-reported questionnaires prior to the intervention (T0, baseline), at mid-intervention (T1, after 3 months) and post-intervention (T2, after 6 months). Baseline assessments took place at the earliest 3 months after surgical resection to allow for adequate wound healing. For practicability and safety reasons, parts of the study personnel were unblinded.
The patients of the two resistance training groups RT1 and RT2 exercised twice a week for approximately 60 minutes for 6 months, according to the exercise guidelines of the American College of Sports Medicine for cancer survivors (15). Both resistance training interventions addressed major muscle groups of the upper and lower extremities. After a four-week adaptation phase, patients performed 8 exercises/session with 2–3 sets with 8–12 repetitions. Exercise intensities were of 60–80% One-Repetition Maximum in RT1 and 14–16 on the Borg Scale of Perceived Exertion (16) in RT2.
Detailed information and results on feasibility and efficacy of the resistance training on muscle strength are described elsewhere (17). Both interventions differed primarily by the mode of delivery (therapist-supervised at an exercise facility on weight machines vs. home-based with a training manual exercising at home supported by weekly phone calls). Patients of the control group received usual care in line with their cancer treatment and were advised not to change exercise behavior. Patients were called once a month and asked about possible treatment-related side effects.
Changes in QoL were assessed using the EORTC C30 (14) and the pancreas-specific module (PAN26) (18). The C30 questionnaire covers a total of 30 items with 9 multi-item scales: 5 functional scales (physical, role, cognitive, emotional and social functioning) and 8 symptom scales (fatigue, pain, nausea/vomiting, dyspnea, sleep problems, appetite loss, constipation, and diarrhea), as well as a global health status and QoL scale. The PAN26 consists of 26 items covering 7 multi-item scales.
Cronbach's alpha ranged from 0.7 to 0.9 for all subscales in our study, except for diarrhea (Cronbach's alpha=0.5). After standard transformations, all scales ranged from 0–100. Higher scores indicated more symptoms and worse health-related QoL, with the exception of global health status, C30 functioning scales, and PAN26 satisfaction with health care scale with higher scores indicating better function and better QoL.
Fatigue was assessed using the German version of the Multidimensional Fatigue Inventory (MFI) (19). The validated 20-item questionnaire consists of 5 subscales (general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue) ranging from 0 to 20, with higher scores indicating more fatigue (Cronbach's alpha=0.63–0.87).
Clinical data and patient characteristics were extracted and validated from the medical records or assessed by self-report of the patients. Weight and height were measured during the assessments. Additionally, patients reported their exercise behavior in the year before the pancreatic cancer diagnosis.
Statistical analyses
Sample size calculations were based on a two-sided F-test (significance level: p<0.05) comparing normal mean differences of 3 groups. Assuming effect sizes (ES) of 0.6 and 0.5 in RT1 and RT2, respectively, and a 25% drop-out rate, recruiting 67 patients per group corresponded to a power (probability of detecting an effect, given that the effect is really there) of 0.82.
Descriptive analyses were based on frequencies or mean values and standard deviations, depending on the scale of the variables. The primary dataset included all patients for which analyzable data were available after 6 months (complete–case analysis). Stability was investigated by comparing results from the complete-case dataset with those from multiple imputation methods (25 datasets). Data for patients who died or had disease progression, preventing further participation, within 6 months, were not substituted during the multiple imputation procedure.
For the primary endpoint (T2), an analysis of covariance (ANCOVA) was performed, with the changes since T0 as the dependent variable, group assignment (according to the intention-to-treat principle) as the independent variable, and the value of the variable at T0 as a covariable. In case of a significant difference between the three groups in the global F-test, paired t-tests were performed within the ANCOVA.
In addition, comparisons of the pooled resistance training group (RT), combining RT1 and RT2, with CON were conducted as exploratory analyses. The ES per training group was calculated by dividing the change from the pretest values to the posttest values by the pretest standard deviation (20, 21). Furthermore, the effects of an additional adjustment to age, sex, body mass index (BMI), time since first chemotherapy, and exercise behavior in the year prior to being diagnosed with pancreatic cancer were investigated. Similar exploratory analyses were performed for all secondary endpoints. The statistical software SAS 9.3 was used for all analyses.
A total of 304 pancreatic cancer patients were approached (Figure 1). Of these, 65 patients were randomized in the study and 47 completed the 6-month intervention phase. The drop-out rate was 22.7% in CON, 25% in RT1 and 32.3% in RT2.
Patients were on average 60.5 years (standard deviation [SD] = 8.4) old. Most patients had a normal weight (mean BMI = 23.7; SD=4.3) and were diagnosed with stage IIB cancer (67.4%) (Table 1). More than half of the patients (53.2%) experienced a weight loss of >10% within 6 months before T0. Patients random^zed to the exercise groups performed on average 1.3 weekly training sessions (out of 2) which corresponds to an overall training adherence rate of 66.5%. Among the 47 patients who completed the 6-month intervention phase, training adherence dropped steadily over the 6 months in RT1 and RT2, from initially 73.6% and 87.5%, respectively, to 41.5% and 62.0% (Figure 2). No adverse events occurred during exercise sessions.
For the primary endpoint, physical functioning, the global test did not indicate an overall between-group difference at 6 months (p=0.93, Table 2). However, at month 3, explorative analyses revealed significant global between-group differences (Table 2). Descriptively, physical functioning increased from baseline to the end of the 6-month intervention similarly in both training groups with reaching the maximum after 3 months (eTable 1). In contrast, CON showed a steady increase during intervention. Mean differences (MD) were statistically significant at 3 months compared to CON for the pooled RT group (MD=11.0; p<0.05), as well as for RT2 (MD=11.8; p=0.02), with a similar but non-significant effect for RT1 (MD=9.1; p=0.14) (Table 2, eTable 1). Sensitivity analyses based on further adjustments and multiple imputations yielded similar results (eTable 2).
For secondary outcomes, all global tests were non-significant at 6 months. At 3 months, the global tests and the comparisons of RT with CON indicated significant differences for global QoL, cognitive functioning, sleep problems, physical fatigue, and reduced activity (Table 2, eTable 3).
The subsequently performed pairwise-comparisons with CON showed similar effects for RT1 and RT2 (eTable 1, Figure 3). The absolute values of effect sizes ranged from 0.16 to 1.14. RT2 showed significant between-group changes for all variables but sleep problems (MD=-14.9; p=0.07; ES=-0.66), RT1 for cognitive functioning (MD=17.9; p=0.01; ES=0.74), sleep problems (MD=-28.2; p=0.01; ES=-1.14), and the PAN26 hepatic (MD= –14.5; p=0.003; ES=-1.10). None of the other PAN26 scales indicated additional differences at any time (eTable 4).
Sensitivity analyses yielded similar results (eTable 2). Two variables with significant results in the complete-case analysis showed no significant differences in the imputed analyses (cognitive function and reduced activity), however, with p-values still between 0.05 and 0.1. Vice-versa, two variables had non-significant p-values ≤0.1 in the complete-case analyses with significant p-values after multiple imputation (role function and fatigue).
This is the first RCT that investigated the effects of resistance training on QoL in pancreatic cancer patients. After the 6-month intervention period, there were no effects of resistance training on the primary endpoint physical functioning as well as on the other assessed QoL parameters. However, after 3 months, favorable effects of resistance training compared to usual care were observed for physical functioning, as well as global QoL, cognitive functioning, sleep problems, physical fatigue, and reduced activity. Between-group differences and the corresponding absolute effect sizes of up to 1.14 after 3 months demonstrated the clinical and practical relevance of resistance training on QoL with moderate-to-large effect sizes (20). Both modes of delivery—supervised and home-based resistance training—showed similar effects.
We did not detect any between-group differences after 6 months. One explanation might be that mid-term training effects after 3 months were later cancelled out to some extent by disease progression. In addition, the adherence rate showed a continuous decline over the course of the intervention period.
Our results after 6 months were comparable with those of the previous exercise RCTs which also reported no between-group effects (12, 13). Our results at mid-intervention were in accordance with research regarding QoL and resistance training in cancer patients with other cancer entities (22–24). Meta-analyses, mainly based on breast and prostate cancer, demonstrated that resistance training held beneficial effects for QoL and physical functioning (25, 26). However, our study revealed higher effect sizes that are rather in line with a recent study on patients with colon cancer (27).
The 3-month results of our study on QoL indicate overall positive effects of resistance training. Here, the pairwise analyses for each parameter found comparable effects in the supervised and home-based resistance training groups. This result is highly relevant for the implementation of resistance training interventions in clinical practice, because not all cancer patients have easy access to training facilities, offering supervised training for patients living with cancer.
The present study has several strengths, especially the randomized controlled design, a good adherence rate to the standardized intervention, intention-to-treat analysis, and the use of a multidimensional assessment tool for QoL and fatigue.
A methodological limitation of this study is the limited sample size, resulting in a reduced generalizability. Recruitment difficulties resulted in lower numbers than originally planned (65 randomized patients instead of 201). Comparable recruitment experiences have been reported in a recent study on lung and pancreatic cancer patients (12). On the other hand, the observed effect sizes were partially higher and we applied more powerful statistical methods for the analyses than were used for the sample size calculations. Consequently, our study design was rather conservative. Nevertheless, the interpretation of the study, especially of non-significant results, need to be performed with caution. Another limitation is the monocentric study design. Further, both resistance training groups were not randomized to each other, resulting in unbalanced group sizes.
This RCT was the first to show that resistance training may be a promising modality to relieve symptoms, improve physical functioning and QoL in pancreatic cancer patients. Given the high symptom burden and the limited survival time of these patients, we consider even the 3-month results as relevant, so that corresponding exercise recommendations should already be given at diagnosis. Future studies need to focus on prolonging the positive mid-term exercise effects, potentially by maintaining regular training.
We would like to thank the patients who participated in this clinical trial. We also thank Lena Kempf and Marcel Bannasch for training support of the supervised training group, Emanuel Schembri for support in the assessments, and Prof. Dr. Jens Werner for clinical advice on designing the trial.
This work was supported by a grant of the German Cancer Aid (SUPPORT-Study Grant No. 110513 and 110552) as well as by additional financial support of the German Cancer Research Center and the University Hospital Heidelberg.
Data sharing
Upon completion of further analyses of the study, the authors are willing to share data with other researchers for scientific purposes. Please address your requests regarding the dataset to the corresponding author.
Conflict of interest
Prof. Steindorf received consultancy fees from Pfizer. She is co-author of the Breast Cancer and Sports brochure published by Pfizer. She received authorship/co-authorship fees for a publication related to the topic from Thieme-Verlag. She received reimbursement of travel expenses and lecture fees form BIC-Krankenkasse Dortmund, from Audi, Bosch, Adviva, and from Asklepios.
Dr. Wiskemann received reimbursement of congress fees and travel expenses as well as lecture fees from Pfizer, Celgene and MSD.
The remaining authors declare no conflict of interest.
Manuscript received on 28 December 2018, revised version accepted on 29 April 2019
Corresponding author
Prof. Dr. rer. nat. Karen Steindorf
Abteilung Bewegung, Präventionsforschung und Krebs
Deutsches Krebsforschungszentrum (DKFZ) und Nationales Centrum für
Tumorerkrankungen (NCT) Heidelberg
Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
Cite this as:
Steindorf K, Clauss D, Tjaden C, Hackert T, Herbolsheimer F, Bruckner T,
Schneider L, Ulrich CM, Wiskemann J: Quality of life, fatigue, and sleep problems in pancreatic cancer patients—a randomized trial on the effects of exercise.
Dtsch Arztebl Int 2019; 116: 471–8. DOI: 10.3238/arztebl.2019.0471
Division of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Germany: Prof. Dr. rer. nat Karen Steindorf, Dr. sc. hum. Dorothea Clauss, Dr. sc. hum. Florian Herbolsheimer
Division of Medical Oncology, National Center for Tumor Diseases and Heidelberg University Hospital, Heidelberg, Germany: Dr. sc. hum. Dorothea Clauss, PD Dr. phil. Joachim Wiskemann
Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany: Dr. med. Christine Tjaden, Prof. Dr. med. Thilo Hackert, Prof. Dr. med. Lutz Schneider
Institute for Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany: Dr. sc. hum. Thomas Bruckner
Department of Population Health Sciences, Huntsman Cancer Institute and University of Utah, Salt Lake City, USA: Prof. Dr. rer. nat. Cornelia M. Ulrich
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|Choi MH, Yoon SB, Lee K, et al.: Preoperative sarcopenia and post-operative accelerated muscle loss negatively impact survival after resection of pancreatic cancer. J Cachexia Sarcopenia Muscle 2018; 9: 326–34 CrossRef MEDLINE PubMed Central
|Pausch T, Hartwig W, Hinz U, et al.: Cachexia but not obesity worsens the postoperative outcome after pancreatoduodenectomy in pancreatic cancer. Surgery 2012; 152: S81–8 CrossRef MEDLINE
|Crippa S, Dominguez I, Rodriguez JR, et al.: Quality of life in pancreatic cancer: analysis by stage and treatment. J Gastrointest Surg 2008; 12: 783–94 CrossRef MEDLINE PubMed Central
|Eaton AA, Gonen M, Karanicolas P, et al.: Health-related quality of life after pancreatectomy: results from a randomized controlled trial. Ann Surg Oncol 2016; 23: 2137–45 CrossRef MEDLINE PubMed Central
|Nieveen van Dijkum EJ, Kuhlmann KF, Terwee CB, Obertop H, de Haes JC, Gouma DJ: Quality of life after curative or palliative surgical treatment of pancreatic and periampullary carcinoma. Br J Surg 2005; 92: 471–7 CrossRef MEDLINE
|Schniewind B, Bestmann B, Henne-Bruns D, Faendrich F, Kremer B, Kuechler T: Quality of life after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head. Br J Surg 2006; 93: 1099–107 CrossRef MEDLINE
|Burke S, Wurz A, Bradshaw A, Saunders S, West MA, Brunet J: Physical activity and quality of life in cancer survivors: a meta-synthesis of qualitative research. Cancers (Basel) 2017; 9. doi:10.3390/cancers9050053 CrossRefMEDLINE PubMed Central
|Dittus KL, Gramling RE, Ades PA: Exercise interventions for individuals with advanced cancer: a systematic review. Prev Med 2017; 104: 124–32 CrossRef MEDLINE
|Titz C, Hummler S, Thomas M, Wiskemann J: Physical exercise in advanced cancer patients undergoing palliative treatment. Expert Review of Quality of Life in Cancer Care 2016; 1: 433–42 CrossRef
|Solheim TS, Laird BJA, Balstad TR, et al.: A randomized phase II feasibility trial of a multimodal intervention for the management of cachexia in lung and pancreatic cancer. J Cachexia Sarcopenia Muscle 2017; 8: 778–88 CrossRef MEDLINE PubMed Central
|Yeo TP, Burrell SA, Sauter PK, et al.: A progressive postresection walking program significantly improves fatigue and health-related quality of life in pancreas and periampullary cancer patients. J Am Coll Surg 2012; 214: 463–75; discussion 75–7 CrossRef MEDLINE
|Aaronson NK, Ahmedzai S, Bergman B, et al.: The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993; 85: 365–76 CrossRef MEDLINE
|Schmitz KH, Courneya KS, Matthews C, et al.: American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 2010; 42: 1409–26 CrossRef MEDLINE
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|Wiskemann J, Clauss D, Tjaden C, et al.: Progressive resistance training to impact physical fitness and body weight in pancreatic cancer patients: a randomized controlled trial. Pancreas 2019; 48: 257–66 CrossRef MEDLINE
|Eaton AA, Karanicolas P, MChir CDJB, Allen PJ, Gonen M: Psychometric validation of the EORTC QLQ-PAN26 Pancreatic Cancer Module for assessing health related quality of life after pancreatic resection. J Pancreas 2017; 18: 19–25.
|Krauß O: Multidimenional Fatigue Inventory. In: Schumacher J, Klaiberg A, Brähler E (eds.): Diagnostische Verfahren zu Lebensqualität und Wohlbefinden. Göttingen: Hogrefe Verlag; 2003.
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|Steindorf K, Wiskemann J, Ulrich CM, Schmidt ME: Effects of exercise on sleep problems in breast cancer patients receiving radiotherapy: a randomized clinical trial. Breast Cancer Res Treat 2017; 162: 489–99 CrossRef MEDLINE
|Hojan K, Kwiatkowska-Borowczyk E, Leporowska E, Milecki P: Inflammation, cardiometabolic markers, and functional changes in men with prostate cancer. A randomized controlled trial of a 12month exercise program. Pol Arch Intern Med 2017; 127: 25–35 CrossRef MEDLINE
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From the Archive - D&AD 2016/
We came across this 2016 D&AD typographic project by Dan Horsefall & Ashley Schofield while trawling the hard drive and thought we'd share it with you.
Please click the image above to play film
We came across this 2016 D&AD typographic project by Dan Horsefall & Ashley Schofield while trawling the hard drive and thought we'd share it with you.
Please click the image above to play film
Here we again feature another Heinz D&AD solution from 2nd year student Sara Esat, based on the speed that Heinz flows from the bottle.
Please click the image to play the film
Here we feature 2nd year student Holly McNicholas' Heinz D&AD entry that again didn't quite make the grade.
Click on image to play film.
Here we feature the first in a series of 2019 D&AD entries that didn't quite make the grade. That said we feel that they are all of an excellent standard, are highly creative solutions and are great portfolio pieces for the students concerned.
This particular solution by 2nd year student Dylan Carr placed Heniz at the centre of every household table.
Click the image to play the film
We'd just like to repeat our congratulations to all this year's D&AD New Blood entrants and winners. The awards were presented by ex-Preston student Harriet Devoy who will spend this year as D&AD President alongside her role as Creative Director of Design, Marketing Communications at Apple EMEIA (Europe, Middle East, India and Africa).
Wood Pencil
- by Yi Zhang & Ariel Austris Tabaks
Yellow Pencil
- by Lucy Child & Francesca Hanley
Heinz State
Wood Pencil
- by Angus Meikle
Fence Fairies
Wood Pencil
- by Gabe Aplando & Jay Austin
The Times
Break the Cycle
Graphite Pencil
- by Brandon Thomas
Virgin Favours the Brave
Wood Pencil
- by Angus Meikle & Dom Parsons
Also, congratulations to ex-student Jack Parker who won yellow, white and black pencils for his adidas entry.
All the students folders can be accessed here classof2019.myportfolio.com
Congratulations to all this years students who have just been nominated for the global student D&AD New Blood Awards. Winners will be announced on Thursday 11th July at the New Blood Awards Ceremony.
Here we feature the nominees:
Good luck to one and all!
Here we feature Harriet Richardsons commended D&AD entry for the Arjo Wiggins paper brief 2017.
'Samples' by Sony is a revolutionary way of creating new experimental sounds like never before, combining the tactile medium of paper with digital sound technology. 'Samples' allows both music artists and Sony customers to turn paper samples into audio samples, whilst also exploring the unique and beautiful medium of paper.
Click the arrow to play the film
A great example of a project built upon a clever verbal connection which combines both the digital and physical to create a unique concept.- Paper Samples & Music Samples or BPM meets GSM.
Here we feature Ashton Hoban's D&AD shortlisted entry from 2017.
Background. The outdoor summer festival scene is growing. There are now more than over 250 festivals taking place every year across the UK, catering for a whole variety of tastes and demographics.
With this in mind John Lewis has decided go beyond its stores and out into the great outdoors by teaming up with one of the UK's leading festivals, Glastonbury. From ponchos to sun cream, come rain or shine 'John Lewis Saves The Day'.
Click the arrow to play the film.
A well thought through solution with a great proposition and a great example of how to tell a story through appropriate image and text. When it comes to all those festival essentials John lewis 'Saves the day'.
Here we feature Amy Wooding's D&AD shortlisted entry from 2017 which was in response to the Amazon Fresh brief. Highly commended.
Click to play film
A very professional well crafted and logical solution demonstrated across a range of touchpoints. A classic example of word & image working effectively to communicate the core offering of Amazon Fresh within the capitol.
© 2019 The Disciples Of Design


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New Music: D-Black Ft. Kidi – 'Obi Ba (Prod. By MOG Beatz)
The young king D-Black teams up with the sensational vocalist KiDi for this masterpiece. Obi Ba is a masterpiece of D-Black's highly anticipated 4th studio album 'LOYALTY'. Produced by MOG Beatz. Enjoy!!
DOWNLOAD D-BLACK FT. KIDI – OBI BA – https://soundcloud.com/user-98448858/d-black-obi-ba-ft-kidi-prod-mog-beatz
Shatta Wale, Stonebwoy Merge In DJ Sly's New Single.
Ghanaian top notch disk jockey and producer, DJ Sly shares a brand new single which he titled "Dance".
"Dance" features Shatta Movement President Shatta Wale and Bhim Nation President Stonebwoy. It comes after the release of his previous hit song 'Ole Alo' featuring Teni, EL,Skales and Daphne. The record was produced by DJ Sly with some classic street melody.
Listen to the record and drop your comment.
1 CeDi – Pressure (Prod By Maestro)
New Music: Funny Face – Lan T (Prod. By Eyoh Soundboy)
LAI NU: Lighter TOD Taps Medikal For New Single.
Rapper Lighter TOD has enlisted colleague rapper and VGMA rapper of the year Medikal on new single.
Believed to be the official Christmas banger, the Liquid beats produced song uses a catchy Ghanaian line "Lai Nu" which literally means feeling in love with something. With his witty wordplay Medikal comes on hard to prove his rapping prowess.
Lighter TOD bust on the music scenes in 2010 when he released "It's my Turn" which gave his nationwide attention in both his native country Ghana and the United State of America where he reside.
Lighter amicable personality has increased his fan base and his catchy hits have made him widespread.
The Crux Global act has worked with international stars like Red Cafe, Sarkodie, Muggex and local compatriots like Joey B, EL, D Black among others.
Listen/ Stream the song here: https://crux-global.lnk.to/lainu
Watch the video here: https://youtu.be/pVBfxUE8GyQ


text:
First Half Comes to a Close on Sunday
By Kevin Fitzgerald | June 16, 2019 5:51 PM
COLUMBIA, SC - The first half of Columbia's season wrapped up on Sunday at Segra Park. While Mark Vientos recorded a pair of hits in the series finale against Lexington, the Legends completed the sweep and defeated the Fireflies, 10-1. Lexington finished a half-game ahead of Charleston in the first half, won the Southern Division and clinched a playoff spot.
While Vientos registered his 10th multi-hit game of the year, the rest of the Columbia (24-42) hitters did little else. Lexington's (37-32) pitchers held the Fireflies to just four hits.
After four scoreless innings, the Legends plated three in the fifth. Simeon Woods-Richardson (L, 1-7) had allowed just three base-runners over the first four but then walked back to back hitters in the fifth. Billy Oxford was called upon out of the bullpen. The first batter he faced, Michael Gigliotti, tripled and both runners scored. Bhret Bewley then knocked in Gigliotti with a ground ball to second base. Shervyen Newton fielded the bouncing ball and fired home, but the runner beat the throw. Lexington led, 3-0.
The visitors added three more the following frame. Jeison Guzman and Gigliotti both drove in runs. Guzman scored from third when the runner at first at the time, Gigliotti, stole second. The throw from behind the plate bounced into centerfield, allowing Guzman to score.
Columbia loaded the bases in the seventh against starter Jon Heasley (W, 6-3) and reliever Austin Lambright (who replaced Heasley after the first two hitters reached). Newton then walked to load the bases. With Brian Sharp batting, Lambright threw a pitch away to the screen which enabled Vientos to score from third. The bases loaded again later in the inning with no outs, but the home team couldn't push any more runs across.
The Legends distanced themselves from the Fireflies with two runs in eighth and ninth innings. Gigliotti wound up with three hits and four RBIs on the day for Lexington.
Columbia ends the first half with a 24-42 mark. The Fireflies are off for the all-star break from June 17-19 but return to action on Thursday in Asheville. Columbia faces the Tourists from Thursday to Sunday before continuing to Lexington for a three-game series from June 24-26.
Fireflies shortstop Ronny Mauricio will play in the 60th South Atlantic League All-Star Game on Tuesday, June 18, in Charleston, West Virginia. You can listen to the game on wvpower.com.
This story was not subject to the approval of the National Association of Professional Baseball Leagues or its clubs.View More


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The Vol. 4, No. 1 (Autumn 1947) issue of Retort, an anarchist publication produced out of Bearsville, New York from 1942-1951.
Contents include:
-Editorials" The new resistance in Russia part II
-Poem: India, the great day by W.B. Yeats
-Art, play and its perversions by Holley Cantine
-Poem by George Sims
-Poem by Alex Comfort
-Poem: Sestina by Dachine Rainer
-Poem: Parable by Pearl Bond
-Poem by Jackson MacLow
-Poem by Martin Dworkin
-Michael Bakunin: a pioneer of anarchist resistance by Michael Grieg
-A refugee from Dalstroi (Interview conducted by Ida Mett, translated by Holley Cantine)
-Review: New world primer by Julien Cornell and The state by Randolph Bourne (Review by Holley Cantine)
-Review: The innocent eye by Herbert Read (Review by Dachine Rainer)
-Review: The coming crisis by Fritz Sternberg (Review by Alexander Lang)
-Review: Bend sinister by Vladimir Nabokov (Review by Holley Cantine)
-Records: Bach; Beethoven; Harmonica Classics; Wagnerian Excerpts; Chansons; Richard Strauss; Debussy
This issue digitized for libcom.org by the Centre International de Recherches sur l'Anarchisme (CIRA) in Lausanne, Switzerland.
|Retort Vol. 4, No. 1 (Autumn 1947).pdf


text: Advertisementby Shawn Sheehan18 Sep 2013Difficulty:IntermediateLength:QuickLanguages:EnglishPortuguêsMotion GraphicsAdobe After EffectsIn this video tutorial, we will use the Offset effect combined with comp-to-comp expressions and Time-remapping to create a parallaxing environment. Parallax is achieved by panning a camera past objects with varying depth inside a scene. We will create parallax without a 3D camera or Z-depth of any kind. AdvertisementShawn SheehanShawn Sheehan is a motion designer and illustrator working in the visual arts medium in southeast Michigan for over 18 years. He has also taught various digital art and animation courses at the college level for over 13 years. And he is a huge classic cartoon and comic book nerd.Feed Like Follow Weekly email summarySubscribe below and we'll send you a weekly email summary of all new 3D & Motion Graphics tutorials. Never miss out on learning about the next big thing.Update me weeklyAdvertisementDownload Attachment TranslationsEnvato Tuts+ tutorials are translated into other languages by our community members—you can be involved too!Translate this postPowered byAdvertisementWatch anycourse now Subscribe to Access


text:
Transition From Launcher to Wargaming.net Game Center
Дата: 20.05.2019 12:10:52
Don_71, on 16 May 2019 - 04:43 PM, said: No, I will not need to use your crap-tool - I will simply go and uninstall WoT. By forcing that WGC on me, you'll just provide the last little bit of motivation to make me go spend my funds elsewhere. This tool will MOVE AWAY the next batch of your long-term players and supporters - congrats, WG shall soon save even more on server-costs... WG should consider that most of the folks you keep annoying again and again already sunk more cash into your "free to play" than in any full-price AAA-title. Better realize and respect that and start delivering long over due game-balance (matchmaker not considering the PR, wtf?), new (or even old) maps etc, instead of just asking for even more cash day by day. What WG really needs to do asap is get back to pleasing their customers again - and therefore they first need to develope a much better understanding of what's annoying the playerbase and driving it away to other games.
eekeeboo: It's impossible to please everyone all the time and actually detrimental to try and please people who would take more resources than those you can please and support without the changes required by others who are not more important to the game. Many customers are already happy, if you are not, this is unfortunate, but if you are pushed to such displeasure from using a tool and service that is a requirement moving forward for a variety of reasons then this is an unfortunate consequence.


text:
Another word for sunless
sunless Synonyms
WEBSTER'S NEW WORLD® ROGET'S A-Z THESAURUS by Charlton Laird and the editors of Webster's New World dictionaries. Copyright © 1999 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Link to this page
Cite this page
MLA Style
"Sunless." YourDictionary. LoveToKnow. thesaurus.yourdictionary.com/Sunless.
APA Style
Sunless. (n.d.). In YourDictionary. Retrieved from https://thesaurus.yourdictionary.com/Sunless