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CURRENT POSITIONS Professor of Medicine, University of Montreal and Scientific Director, Neuroscience Research Unit, St-Luc Hospital, Montreal
B.Sc. (Honours), Biochemistry and Physics, University of London 1966
Ph.D., Biochemistry, University of London 1969
D.Sc., Neurological Sciences, University of London 1996
1970-72 Postdoctoral Research Fellow, Department of Chemistry, University of Montreal
1972-74 Research Associate, Laboratory of Neurobiology, Clinical Research Institute of Montreal (University of Montreal)
1975-79 Research Fellow, Assistant Director, Department of Neurobiology, Clinical Research Institute of Montreal (University of Montreal)
1976-82 Assistant Professor, Department of Medicine, University of Montreal
1979-83 Director, Laboratory of Neurochemistry, Clinical Research Institute of Montreal (University of Montreal)
1982-84 Visiting Professor, Department of Health Sciences, Concordia University
1983-89 Associate Professor, Department of Medicine, University of Montreal
1983-89 Senior Research Fellow, FRSQ
1983-1992 Director, Laboratory of Neurochemistry, André-Viallet Clinical Research Centre, Hôpital Saint-Luc (University of Montreal)
1985-2014 Member, Research Center in Neurological Sciences, University of Montreal
1986-2014 Member, University of Montreal Research Group in Hepatology
1986 Visiting Scientist, INSERM U-29, Hôpital Port-Royal, Paris, France
1989-present Full Professor, Department of Medicine, University of Montreal
1990-present Adjunct Professor, Department of Experimental Medicine, McGill University
1991-1995 Associated scientist and member, Research Ethics Board, Douglas Hospital Research Centre, McGill University
1992 Visiting Professor, Clinical Pharmacology Institute, University of Lund Hospital, Lund, Sweden.
1992-2014 Scientific Director, Neuroscience Research Unit, Hôpital Saint-Luc (CHUM, University of Montreal)
1996 Visiting Professor, Dept. of Pathology, University of Sydney, Sydney, Australia.
1999-2007 Adjunct Professor, Dept. of Biochemistry, University of Queensland, Brisbane, Australia
1999-2005 Associate Researcher, Sacré-Coeur Hospital Research Centre, University of Montreal
2000 Visiting Professor, Instituto Investigaciones Citologicas de la Fundacion Valenciana de Investigaciones Biomedicas, Valencia, Spain
Awarded 'Order of Senegal' medal for contribution to the advancement of Neuroscience in Africa, Dakar, Senegal, 1998
Awarded Gold Medal of Canadian Liver Foundation, Banff, Alberta, 2003
President, International Society for Neurochemistry (ISN), 2006-2007
President, International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) 2009-2011
"Andy Blei Lecture", ISHEN, 2014
Member, Ad Hoc Review Committee, Developmental Neuroscience Program, National Science
Foundation, Washington, D.C., 1986
Member, NIH site visit team to University of Michigan, PET Center, August 1991
Member, Executive Board, André-Viallet Clinical Research Center, 1991-1997
Member, NIH evaluation team, Dept. of Pediatrics, University of Baltimore, Baltimore, USA, November
Member, Scholarship Awards Committee, Medical Research Council of Canada, 1993-1996
Member, NIH Site Visit Team, Dept. of Pediatrics, University of Baltimore, MD, USA, March 1997
Member, Molecular and Cellular Neurosciences Study Section, NIH, Bethesda, October 1998
Member, Consultative Committee on Research Priorities in the CHUM, March 1999
Member, Committee for renovation of André-Viallet Clinical Research Centre, CHUM, March 1999
Members and consultant, NIH/Fogarty Foundation meeting on research and support priorities in Africa, Washington DC, April 2002
Member, NIH consultant team to Dept. of Pediatrics, University of Baltimore, USA, June 2002
Member, NIH Molecular and cellular Neuroscience Study Sections, Washington DC, June 2003
1984-1990 Member, Editorial board, "Metabolic Brain Disease"
1987 Editor, special issue of "Neurochemical Pathology", publication of ASN Symposium entitled "Neurochemical Consequences of Hepatic Disease"
1988 Guest Editor, "Neuromethods", Volume 15, "Carbohydrates and Energy Metabolism"
1988-present Member, Editorial Board, "Behavioral and Brain Functions"
1989 Editor, "Hepatic Encephalopathy: Pathophysiology and Treatment", Humana Press, U.S.A.
1989-2010 Member, Editorial Board, "Hepatology"
1990 Editor, "(Mal) Nutrition and the Infant Brain", Alan Liss, U.S.A.
1990-1994 Associate Editor, "Metabolic Brain Disease"
1992 Guest Editor, "Neuromethods", Volumes 22 and 23, "Animal Models of Neurological Disease"
1993-1999 Member, Editorial Board, "African Journal of Neuroscience"
1994-1998 Chief Editor, "Metabolic Brain Disease"
1994-2004 Assistant Editor, "Addiction Biology"
1998-2010 Editor-in-Chief, "Neurochemistry International"
1998-present Associate Editor, "Metabolic Brain Disease"
1999-2007 Member, Editorial Board, "Journal of Hepatology"
1999-2010 Member, Editorial Board, "International Journal for Developmental Neuroscience"
SCIENTIFIC ASSOCIATIONS Since:
- President Elect, 2005
- President, 2009
- Past President, 2011
- Council member, 1997-2001
- Treasurer, 2001-2005
- President Elect, 2005
- President, 2006-2007
- Member, Organizing Committee, Annual Meeting, 1986
- Member, Neurochemistry and Public Policy Committee, 1987-1990
- Member, Programme Committee, Annual Meetings, 1993
- Council member, 1998-2003
- Member, Governing Board, 1991-1994
- Secretary/Treasurer, 1999-2003
- Member, Program Committee, 1992-1994
RESEARCH SUPPORT (from 2005 to 2011)
(a) COMPLETED GRANTS
MOP 15065 (Roger F. Butterworth, PI) 1998-10-01 – 2008-09-30
Canadian Insitutes of Health Research, Nutrition, Metabolism and Diabetes
Further studies on the pathogenesis of portal-systemic encephalopathy, a major neurological complication of chronic liver failure
MOP 74474 (Roger F. Butterworth, PI) 2005-04-01 – 2008-03-31
Further studies of vascular factors in the pathogenesis of selective neuronal cell death due to impaired oxidative metabolism
CCI 85676 (Roger F. Butterworth and Liang Peng, PI) 2008-01-01 – 2010-12-31
Canadian Insitutes of Health Research, Nutrition, Metabolism and Diabetes (China-Canada Joint Health Research Initiative)
Towards a rational therapy for the cerebral complications of liver failure
(b) operating GRANTS
MOP 15065 (Roger F. Butterworth, PI) 1998-10-01 – 2011-09-30
Further studies on the pathogenesis of hepatic encephalopathy and brain edema, major neuropsychiatric complications of acute liver failure
PRG 80160 (Leonard J. Hoffer, PI) 2006-04-01 – 2011-03-31
Canadian Insitutes of Health Research, Research Resource Grant Program
Mass spectrometry facility maintenance
PEER-REVIEWED JOURNALS AND REVIEW ARTICLES (selected from a total of 984) 1997-2019
Raghavendra Rao, V.L., Audet, R.M. and Butterworth, R.F.: "Portacaval shunting and hyperammonemia stimulate the uptake of L-3H-arginine but not L-3H-nitroarginine into rat brain synaptosomes" J Neurochem 68(1): 337-343, 1997
Michalak, A. and Butterworth, R.F.: "Selective loss of binding sites for the glutamate receptor ligands [3H]kainate and (S)-[3H]5-fluorowillardiine in the brains of rats with acute liver failure" Hepatology 25(3): 631-635, 1997
Therrien, G., Butterworth, J., Rose, C. and Butterworth, R.F.: "Protective effect of L-carnitine in ammonia-precipitated encephalopathy in portacaval shunted rats: evidence for a central mechanism of action" Hepatology 25(3): 551-556, 1997
Mousseau, D.D., Baker, G.B. and Butterworth, R.F.: "Increased density of catalytic sites and expression of brain monoamine oxidase A in humans with hepatic encephalopathy" J Neurochem 68(3): 1200-1208, 1997
Butterworth, R.F.: "Hepatic encephalopathy and brain edema in acute hepatic failure: Does glutamate play a role?" Hepatology 25(4): 1032-1034, 1997
Schenker, S. and Butterworth, R.F.: "NMR spectroscopy in portal-systemic encephalopathy: are we there yet?" Gastroenterology 112(5): 1758-1761, 1997
Kril, J.J. and Butterworth, R.F.: "Diencephalic and cerebellar pathology in alcoholic and nonalcoholic patients with end-stage liver disease" Hepatology 26(4): 837-841, 1997
Michalak, A., Rose, C., Buu, P.N.T. and Butterworth, R.F.: "Evidence for altered central noradrenergic activity in experimental acute liver failure" Hepatology 27(2): 362-368, 1998
Butterworth, R.F.: "Excitatory neurons and schizophrenia" Lancet 352(9141):1643, 1998
Todd, K.G. and Butterworth, R.F.: "Early microglial response in experimental thiamine deficiency: An immunohistochemical analysis" Glia 25(2):190-198, 1999
Todd, K. and Butterworth, R.F.: "Mechanisms of selective neuronal cell death due to thiamine deficiency" Ann N Y Acad Sci 893: 404-411, 1999
Rose, C., Michalak, A., Rama Rao, K.V., Quack, G., Kircheis, G. and Butterworth, R.F.: "L-Ornithine-L-Aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure" Hepatology 30(3): 636-640, 1999
Rose, C., Butterworth, R.F., Zayed, J., Normandin, L., Todd, K., Spahr, L., Huet, P.-M., and Pomier Layrargues, G.: "Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction" Gastroenterology 117(3): 640-644, 1999
Rose, C, Michalak, A., Pannunzio, M., Chatauret, N., Rambaldi, A. and Butterworth, R.F.: "Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure" Hepatology 31(4): 872-877, 2000
Butterworth, R.F.: "Complications of cirrhosis III. Hepatic encephalopathy" J Hepatol 32(1 Suppl): 171-180, 2000
Lozeva, V., Tuomisto, L., Sola, D., Plumed, C., Hippelainen, M. and Butterworth, R.F.: "Increased density of brain histamine H1 receptors in rats with portacaval anastomosis and in cirrhotic patients with chronic hepatic encephalopathy" J Hepatol 33(6): 1370-1376, 2001
Hazell, A.S., Rama Rao, K.V., Danbolt, N.C., Pow, D.V. and Butterworth, R.F.: "Selective downregulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy" J Neurochem 78(3): 560-568, 2001
Butterworth, R.F.: "Images of the brain in chronic liver failure" J Hepatol 35(5): 661-662, 2001
Corbalan, R., Chatauret, N., Behrends, S., Butterworth, R.F. and Felipo, V.: "Region-selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients" Hepatology 36(5): 1155-1162, 2002
Butterworth, R.F.: "Pathogenesis of hepatic encephalopathy: new insights from neuroimaging and molecular studies" J Hepatol 39(2): 278-285, 2003
Chatauret, N., Zwingmann, C., Rose, C., Leibfritz, D. and Butterworth, R.F.: "Effects of hypothermia on brain glucose metabolism in acute liver failure: a 1H/13C-nuclear magnetic resonance study" Gastroenterology 125(3): 815-824, 2003
Zwingmann, C., Chatauret, N., Leibfritz, D. and Butterworth, R.F.: "Selective increase of brain lactate synthesis in experimental acute liver failure: Results of a [1H/13C] nuclear magnetic resonance study" Hepatology 37(2): 420-428, 2003
Lozeva, V., Tuomisto, L., Tarhanen, J. and Butterworth, R.F.: "Increased concentrations of histamine and its metabolite, tele-methylhistamine and down-regulation of histamine H3 receptor sites in autopsied brain tissue from cirrhotic patients who died in hepatic coma" J. Hepatol 39(4): 522-527, 2003
Lozeva, V., Montgomery, J.A., Tuomisto, L., Rocheleau, B.,Pannunzio, M., Huet, P-M. and Butterworth, R.F.: "Increased Brain Serotonin Turnover Correlates with the Degree of Shunting and Hyperammonemia in Rats Following Variable Portal Vein Stenosis" J Hepatol 40(5): 742-748, 2004
Butterworth R.F.: "Reply to Dr F. Salerno" J Hepatol 42(3): 423, 2005
Ahboucha, S., Pomier-Layrargues, G., Mamer, O. and Butterworth, R.F.: "Increased brain concentrations of a neuroinhibitory steroid in human hepatic encephalopathy" Ann Neurol 58(1): 169-170, 2005
Bélanger, M., Desjardins, P., Chatauret, N., Rose, C. and Butterworth, R.F.: "Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure" J Hepatol 42(5): 694-699, 2005
Vaquero, J., Rose, C. and Butterworth, R.F.: "Keeping cool in acute liver failure: Rationale for the use of mild hypothermia" J Hepatol 43(6): 1067-1077, 2005
Bélanger, M., Desjardins, P., Chatauret. N. and Butterworth, R.F.: "Selectively increased expression of the astrocytic/endothelial glucose transporter protein GLUT1 in acute liver failure (p NA)" Glia 53(5): 557-562, 2006
Chatauret, N., Desjardins, P., Zwingmann, C., Rose, C., Rama Rao, K.V. and Butterworth, R.F.: "Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure" J Hepatol 44(6): 1083-1088, 2006
Vaquero, J., Bélanger, M., Blei, A.T. and Butterworth, R.F.: "Lack of assessment of body temperature in mice with acetaminophen toxicity" Hepatology 44(1): 279-280, 2006
Vaquero, J. and Butterworth, R.F.: "The brain glutamate system in liver failure" J Neurochem 98(3): 661-669, 2006
Vaquero, J., Bélanger, M., James, L., Herrero, R., Desjardins, P., Cote, J., Blei, A.T. and Butterworth, R.F.: "Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity" Gastroenterology 132(1): 372-383, 2007
Vaquero, J. and Butterworth, R.F.: "Mild hypothermia in the treatment of acute liver failure: what are we waiting for?" Nat Clin Pract Gastroenterol Hepatol 4(10): 528-529, 2007
Navarro, D., Zwingmann, C. and Butterworth, R.F.: "Region-selective alterations of glucose oxidation and amino acid synthesis in the thiamine-deficient rat brain: a re-evaluation using (1)H/(13)C NMR spectroscopy" J Neurochem 106(2): 603-312, 2008
Butterworth, R.F.: "Rifaximin and Minimal Hepatic Encephalopathy" Am J Gastro 106: 317-318, 2011
Butterworth R.F, "Hepatic Encephalopathy" in The Liver: Biology and Pathobiology, 5th edition (I. Arias, N. Fausto, Cohen, Shafritz, Alter and J. Boyer, eds.), Raven Press, pp. 595-614, 2009
Butterworth, R.F.: "Hepatic encephalopathy" in Metabolic Encephalopathy (D.W. McCandless, ed.), Springer, New York, pp. 149-180, 2009.
Butterworth, R.F.: "Hepatic encephalopathy: a primary astrocytopathy" in Astrocytes in Pathophysiology of the Nervous System (V. Parpura, ed.), Springer, New York, pp. 673-692, 2009.
Vaquero, J. and Butterworth, R.F.: "Approach to the patient with central nervous system and pulmonary complications of end-stage liver disease" in Principles of Gastroenterology (T. Yamada, D.H Alpers, A.N. Kalloo, N. Kaplowitz, C. Owyang, D.W Powell, eds.), Blackwell Publishing, Oxford, pp.467-491, 2009.
Vaquero, J. and Butterworth, R.F.: "Central nervous system and pulmonary complications of end-stage liver disease" in Textbook of Gastroenterology 5th edition (T. Yamada, D.H Alpers, A.N. Kalloo, N. Kaplowitz, C. Owyang, D.W Powell, eds.), Blackwell Publishing, Oxford, pp. 2327-2351, 2009.
Vaquero, J. and Butterworth, R.F.: "Central nervous system and pulmonary complications of end-stage liver disease" in Atlas of Gastroenterology 4th edition (T. Yamada, D.H Alpers, A.N. Kalloo, N. Kaplowitz, C. Owyang, D.W Powell, eds.), Blackwell Publishing, Oxford, pp. 698-710, 2009.
Jiang, W., Desjardins, P. and Butterworth, R.F.: "Central inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline" J Neurochem 109: 485-493, 2009
Jiang, W., Desjardins, P. and Butterworth, R.F.: "Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia" J Cereb Blood Flow Metab 29: 944-952, 2009
Sawara, K., Desjardins, P., Chatauret, N., Kato, A., Suzuki, K. and Butterworth, R.F.: "Alterations in expression of genes coding for proteins of the neurovascular unit in ischemic liver failure" Neurochem Int 55(1-3): 119-123, 2009
Jiang, W., Desjardins, P. and Butterworth, R.F.: "Hypothermia attenuates oxidative/nitrosative stress and brain edema in acute (ischemic) liver failure" Neurochem Int 55(1-3): 124-128, 2009
Butterworth, R.F., Norenberg, M., Felipo, V., Ferenci, P., Albrecht, J. and Blei A.T.: "Experimental Models of Hepatic Encephalopathy: ISHEN guidelines" Liver Int 29(6): 783-788, 2009
Jiang, W., Desjardins, P. and Butterworth, R.F.: "Minocycline attenuates oxidative/nitrosative stress and cerebral complications of acute liver failure in rats" Neurochem Int 55(7): 601-605, 2009
Bémeur, C., Chastre, A., Desjardins, P. and Butterworth, R.F.: "No changes in expression of tight junction proteins or blood-brain barrier permeability in azoxymethane-induced experimental acute liver failure" Neurochem Int 56: 205-207, 2010
Bémeur, C., Qu, H., Desjardins, P. and Butterworth, R.F.: "IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure" Neurochem Int 56: 213-215, 2010
Bémeur, C., Desjardins, P. and Butterworth, R.F.: "Evidence for oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy" Metab Brain Dis 25(1): 3-9, 2010
Chastre, A., Jiang, W., Desjardins, P. and Butterworth, R.F.: "Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure" Metab Brain Dis 25(1): 17-21, 2010
Bémeur, C., Desjardins, P. and Butterworth, R.F.: "Antioxidant and Anti-inflammatory Effects of Mild Hypothermia in the Attenuation of Liver Injury Due to Azoxymethane Toxicity in the Mouse" Metab Brain Dis 25(1): 23-29, 2010
Butterworth, R.F.: "MetalToxicity, Liver Disease and Neurodegeneration" Neurotox Res 18(1): 100-115, 2010
Bémeur, C., Vaquero, J., Desjardins, P. and Butterworth, R.F.: "N-Acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms" Metab Brain Dis 25(2): 241-249, 2010
Butterworth, R.F.: "Altered glial–neuronal crosstalk: Cornerstone in the pathogenesis of hepatic encephalopathy" Neurochem Int 57: 383-388, 2010
Xue, Z., Li, B., Gu, L., Hu, X., Li, M., Butterworth, R.F. and Peng, L.: "Increased Na, K-ATPase alpha(2) isoform gene expression by ammonia in astrocytes and in brain in vivo" Neurochem Int 57: 395-403, 2010
Beauchesne, E., Desjardins, P., Butterworth, R.F. and Hazell, A.S.: "Up-regulation of caveolin-1 and blood-brain barrier breakdown are attenuated by N-acetylcysteine in thiamine deficiency". Neurochem Int 57: 830-837, 2010
Dhiman R.K, Saraswat V.A, Sharma B.K, Sarin S.K, Chawla Y.K, Butterworth R.F, et al., Minimal hepatic encephalopathy:Consensus statement of a working party of the Indian National Association for Study of the Liver, J Gastroenterol. Hepatol., 25, 1029-1041, 2010
Bémeur, C., Desjardins, P. and Butterworth, R.F.: "Role of Nutrition in the Management of Hepatic Encephalopathy in End-Stage Liver Failure" J Nutr Metab Epub 2011 Dec 22 doi:10.1155/2010/489823
Butterworth, R.F.: "Rifaximin and Minimal Hepatic Encephalopathy" Am. J Gastroenterol. 106, 317-318, 2011
Bajaj, J., Cordoba, J., Mullen, K., Amodio, P., Shawcross, D.L., Butterworth, R.F. and Morgan, M.Y.: "Review article: the design of clinical trials in hepatic encephalopathy--an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement.", Aliment Pharmacol Ther. 2011 Apr;33(7):739-47
Butterworth, R.F.: "Hepatic Encephalopathy: a central neuroinflammatory disorder?" Hepatology 53, 1372-1376, 2011
Bémeur, C., Montgomery, J.A. and Butterworth, R.F.: "Vitamin Deficiencies and Brain Function" in Neurochemical Mechanisms in Disease (J. Blass, ed.), Springer Science+Business Media, pp. 103-124, 2011
Butterworth R.F., "Neuroinflammation in acute liver failure: mechanisms and novel therapeutic targets.", Neurochem Int. 2011 Nov;59(6):830-6.
Chastre A, Belanger M, Beauchesne E, Nguyen BN,Desjardins P and Butterworth RF., "Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications.", PLoS One 7, e49670, 2012
Butterworth R.F. "Liver: risk of falls in cirrhosis predicted by psychometric testing.", Nat Rev Gastroenterol Hepatol. 2012 Feb 21;9(4):197-8
Butterworth R.F., Neuroinflammation in the pathogenesis of hepatic encephalopathy, in "Hepatic Encephalopathy" (Mullen KD and Prakash RK, eds), Clin Gastroenterol, 3, 19-34, 2012
Desjardins P, Du T, Jiang W, Peng L and Butterworth R.F: "Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined. Neurochem. Int., 60, 690-696, 2012
Ahboucha S, Talani G, Fanutza T, Sanna E, Biggio G, Gamrani H and Butterworth R.F, Reduced brain levels of DHEAS in hepatic coma patients: Significance for increased GABAergic tone in hepatic encephalopathy, Neurochem Int. 2012 Jul;61(1):48-53
Butterworth, R.F.: "Role of Ammonia and Neurosteroids in the Pathogenesis of HE" in Hepatic Encephalopathy (K. Mullen and R. Prakash, eds), Springer Science+Business Media, 2012
José I. Fortea, Javier Vaquero and Roger F. Butterworth. "Clinical and Experimental Relevance of Hypothermia in Acetaminophen Hepatotoxicity." In Hypothermia: Prevention, Recognition and Treatment, Juan I. Valdez Delgado and Verman G. Fernandez Garza (Eds.) Nova Science Publishers 2012
Amodio, P., Bémeur, C., Butterworth, R.F., Cordoba, J., Kato, A., Montagnese, S., Morgan, M.M., Uribe, M., Vilstrup, H. "The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus." Hepatology. 2013 Jul;58(1):325-36.
Mireille Bélanger, Javier Vaquero, Roger F. Butterworth. "Neuroglia in Hepatic Encephalopathy." In Neuroglia (3rd Edition), Helmut Kettenmann and Bruce R. Ransom (Eds.) Oxford University Press 2013
Bémeur, C. and Butterworth, R.F.: "Thiamin in Modern Nutrition" in Health in Disease, 11th edition (C. Ross, B. Caballero, R. J. Cousins, K. L. Tucker and T. R. Ziegler, eds.), Lippincott Williams & Wilkins, 2013
Bemeur C and Butterworth R.F., "Liver-brain proinflammatory signalling in acute liver failure: role in the pathogenesis of hepatic encephalopathy and brain edema, Metab Brain Dis., 28, 145-150, 2013
Butterworth R.F," Parkinsonism in cirrhosis: pathogenesis and current therapeutic options", Metab Brain Dis. 2013 Jun;28(2):261-7
Butterworth R.F, "The liver-brain axis in liver failure: Neuroinflammation and encephalopathy", Nat Rev Gastroenterol Hepatol. 2013 Sep;10(9):522-8
Chastre A, Belanger M, Nguyen B.N., and Butterworth R.F., "Lipopolysaccharide precipitates hepatic encephalopathy and increases blood-brain barrier permeability in mice with acute liver failure", Liver Int. 2014 Mar;34(3):353-61
Thumburu K K, Dhiman R.K, Vasishta E.J, Butterworth R.F et al., "Expression of astrocytic genes coding for proteins implicated in neural excitation and brain edema is altered after acute liver failure, J Neurochem. 2014 Mar;128(5):617-27.
Ignatowski TA, Spengler RN, Dhandapani KM, Folkersma H, Butterworth RF et al., "Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence.", CNS Drugs. 2014 Aug;28(8):679-97
Butterworth R.F., "Pathophysiology of brain dysfunction in hyperammonemic syndromes: the many faces of glutamine", Mol Genet Metab. 2014 Sep-Oct;113(1-2):113-7
Butterworth R.F., "Hepatic encephalopathy in alcoholic cirrhosis.", Handb Clin Neurol. 2014;125:589-602.
Bemeur C and Butterworth R.F., "Nutrition in the management of cirrhosis and its neurological complications.", J. Clin. Exp. Hepatol., 4, 141-150, 2014
Butterworth R.F., "Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure.", J Clin Exp Hepatol. 2015 Mar;5(Suppl 1):S96-S103
Butterworth R.F., A Tribute to a Dear Colleague: Joan (Juan) Cordoba 1964-2014, J. Clin. and Exp. Hepatol., 5, 001, 2015.
Butterworth R.F., "Etiology of cirrhosis predicts deterioration of "brain reserve" after hepatic encephalopathy or transjugular intrahepatic portosystemic shunt." Liver Transpl. 2015 Sep;21(9):1115-6.
Butterworth R.F., "Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities.", J Steroid Biochem Mol Biol. 2016 Jun;160:94-7
Butterworth R.F., "The concept of "the inflamed brain" in acute liver failure: mechanisms and new therapeutic opportunities.", Metab Brain Dis. 2016 Dec;31(6):1283-1287
Butterworth R.F., "Pathogenesis of hepatic encephalopathy in cirrhosis: the concept of synergism revisited.", Metab Brain Dis. 2016 Dec;31(6):1211-1215.
Butterworth R.F., Kircheis G, Hilger N, McPhail MJW, "Efficacy of l-Ornithine l-Aspartate for the Treatment of Hepatic Encephalopathy and Hyperammonemia in Cirrhosis: Systematic Review and Meta-Analysis of Randomized Controlled Trials.", J Clin Exp Hepatol. 2018 Sep;8(3):301-313
Butterworth R.F. and Canbay A, "Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease", Dig Dis. 2019;37(1):63-68
Butterworth R.F., "L-Ornithine L-Aspartate (LOLA) for the Treatment of Hepatic Encephalopathy in Cirrhosis: Novel Insights and Translation to the Clinic.", Drugs. 2019 Feb;79(Suppl 1):1-3
Butterworth R.F., "Hepatic Encephalopathy in Cirrhosis: Pathology and Pathophysiology.", Drugs. 2019 Feb;79(Suppl 1):17-21
Butterworth R.F. and McPhail MJW, "L-Ornithine L-Aspartate (LOLA) for Hepatic Encephalopathy in Cirrhosis: Results of Randomized Controlled Trials and Meta-Analyses.", Drugs. 2019 Feb;79(Suppl 1):31-37
Butterworth R.F., "L-Ornithine L-Aspartate for the Treatment of Sarcopenia in Chronic Liver Disease: The Taming of a Vicious Cycle.", Can J Gastroenterol Hepatol, vol. 2019, Article ID 8182195, 6 pages, 2019. https://doi.org/10.1155/2019/8182195.
Butterworth, R.F. " L-ornithine L-aspartate for the Treatment of Sarcopenia in Cirrhosis: Potential Impact on the Outcome of Liver Transplantation." Ann Gastroenterol Dig Dis. 2019, 2(1): 006-009.
Butterworth R.F. "Beneficial effects of L-Ornithine L-Aspartate for prevention of overt hepatic encephalopathy in patients with cirrhosis: a systematic review with meta-analysis.", Metab Brain Dis 2019, in press
Butterworth R.F., "L-Ornithine L-Aspartate: Multimodal Therapeutic agent for Hyperammonemia and Hepatic Encephalopathy in Cirrhosis", J Pharmacol Pharm Res 2019, in press
Butterworth R.F. and Gruengreiff K, "L-ornithine L-aspartate for the treatment of hepatic encephalopathy in cirrhosis: evidence for novel hepatoprotective mechanisms.", JSM Liv Clin Res 2019, in press
Butterworth R.F., "Hepatic encephalopathy" in The Liver:Biology and pathobiology, 6th Ed., I Arias, H Alter, J Boyer, D Cohen, S Torgeirsson, D Shafritz, A Wolkoff, Eds, John Wiley &Sons, UK, 2019, in press.
Presentations as guest speaker 2009-2019
Invited speaker, 19th Asian Pacific Association for the Study of the Liver, Hong Kong, China, February 2009
Invited speaker, Canadian Digestive Week and 5th Ann ual Canadian Association for the Study of the Liver Winter Meeting, Banff, Canada, February 2009
Chair and invited speaker, Colloquium "Why the Brain Fails When the Liver Ails", 40th American
Society for Neurochemistry Meeting, Charleston, USA, March 2009
Invited speaker, "Neurochemical mechanisms of neurodegenerative disorders", IV Neurotoxicity Society Meeting, Arica, Chile, April 2009
Invited speaker, 5th International Hannover Conference on Hepatic Encephalopathy, Hannover, Germany, May 2009
Invited speaker, 5th Forum of Hepatic Encephalopathy, Morokia, Japan, August 2009
Invited speaker, ISN/APSN 22nd Biennial Congress, Busan, Korea, August 2009
Invited speaker, International Symposium on Hyperammonemia and Hepatic Encephalopathy, Valencia, Spain, September 2009
Invited faculty and invited speaker, 60th Annual meeting of of the American Association for the Study of the Liver (AASLD), Boston, USA, November 2009
Organizer and invited faculty, ISN-IBRO Neuroscience School, Fayoum, Egypt, December 2009
Invited speaker, 9th International Society of Neuroscientists of Africa Conference, Sharm-el-Sheikh, Egypt, December 2009
Research seminar, Institut de Recerca, Liver Unit, Hospital Vall Hebron, Barcelona, Spain, March 2010.
Research seminar, Liver Unit, Hospital Clínic de Barcelona, Barcelona, Spain, March 2010.
Invited speaker, EASL-ISHEN joint workshop "Hepatic Encephalopathy: New Therapies and New Trials", International Liver Congress (EASL), Vienna, Austria, April 2010.
Invited speaker, Merz Satellite Symposium "Minimal Hepatic Encephalopathy – a Significant Complication of Cirrhosis", International Liver Congress (EASL), Vienna, Austria, April 2010.
Invited faculty, Gastroenterology Course "Challenges in diagnostics and therapies in gastroenterology and hepatology", INCMNSZ Hospital, Mexico, Mexico, July 2010.
Invited speaker, Ditan International Conference on Infectious Diseases (DICID), Beijing, China, July 2010.
Invited speaker, GIGA, University of Liege, September 2010.
Invited speaker, British Association for Study of the Liver Annual Meeting, Edinburgh, U.K., September 2010.
Organizer /Speaker, 14th ISHEN Symposium, Val-David, Canada, September 2010.
Invited Speaker, British Gastroenterology Society meeting, Birmingham, UK, 14-17 March 2011.
Invited Speaker, Indian Association for the Study of the Liver, Chandigarh, India, 24-27 March, 2011.
Invited Speaker, EASL-ISHEN Workshop on Hepatic Encephalopathy, Berlin, Germany, 30 March, 2011.
Invited Speaker, EASL-Merz Workshop on Pre/Post-OLT Neurological Symptoms in Cirrhosis, Berlin, Germany, 2 April, 2011.
Invited Speaker, Transplant Center Grand Rounds, Mayo Clinic, Florida, USA, 30 June, 2011.
Invited Speaker, Brazilian Congress of Hepatology, Bahia, Brasil, July, 2011
Invited Speaker, Transplant Grand Rounds, University of Iowa, Iowa, USA, September , 2011
Plenary Lecture, 15th ISHEN Symposium, Aarhus, Denmark, May 2012
Invited Speaker, Transplant Grand Rounds, University of Idaho, Nebraska, USA, June 2012
Opening Lecture, Japanese Digestive Diseases Week (JDDW), Kobe,Japan. October 2012
"The Andy Blei Lecture", 16th ISHEN Symposium, London, UK, May 2014
Invited Speaker, 8th International Conference on thiamine: from catalysis to pathology, Liege, Belgium, May, 2014
Invited Speaker, International Gastroenterology Summit meeting, Luxor, Egypt, February, 2015
Invited Speaker, 8th International Meeting: Steroids and the Nervous System, Torino, Italy, February 2015
Invited Speaker, 17th ISHEN Symposium, Delhi, India, March 2017
Invited speaker/Chair, Merz Satellite Symposium "New dimensions in the treatment of chronic liver diseases and hepatic encephalopathy", International Liver Congress (EASL), Vienna, Austria, April 2019.
Invited Speaker, 18th ISHEN Symposium, Williamsburg, VA, USA, September 2019


text:
Apple Computer continued to lead the U.S. digital music player market in the second quarter with a 75.6% share, according to the NPD Group.
"Apple has done a great job of focusing consumers' attention on digital music in their products through millions of dollars in advertising," said Ross Rubin, analyst at the NPD Group, via e-mail.
Read the complete story here. (PC World)

subset: commoncrawl


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Sign up for a new account in our community. This driver is made to support cards based on the E-mu 10k1, 10k2 and similars like what is used by audigy rx and audigy 4 cards. This has been the result ever since El Capitan. Try the Automatic Driver Update Utility , or you can request a driver and we will find it for you. Actually I'd cut anything behind the RX and use "Sound Blaster", because this is what the packaging says. The time now is Second Encounter, Quake3, Quake3:
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Installation Issues For Hexus in the labs the card installed sudigy a dream. Ask A Question Please enter your question. New 16 Oct 5. Always choose the last option until you see a "Have disk" button. Sound Card Supported OS: Works with Windows 8 We have updated audio drivers that will allow you to enjoy the ultimate Sound Blaster performance for Windows 8.
Sound Blaster Audigy SE – – Creative Labs (United States)
Maybe it can be installed on other HP Pavillion Pplayer series laptops, but in some cases additional fixes will have to be made. I want to thank the whole community for their efforts and content provided, because without these it would not be possible to create this installer. I am using now Sierra. Enjoy an audio experience that's just not possible with basic motherboard audio. New 18 Oct 9. It worked, no auddigy.
If not, they will give a warning and quit. Hear your enemies before they find you with 3D positional audio over multichannel speakers. Some users claim that using VoodooHDA they hear loud bump at system start and sound in system comes with noise.
Comprehensive Creative Media Source software provided. Listen to your favorite MP3 music in breathtaking 7.
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Sound Blaster Audigy SE
This check box must be selected to avoid reinstallation issues. Restart the computer and you should be OK. Ah, that sounds great. This is an issue, Creative really need to get it resolved or else there could be more and more issues which could crop up, There is a new revision of the card on the market which resolves the problems and one of our test pllayer was fine, the other exhibited the problems.
If it is not properly installed it could be listed as other devices or unknown instead. With Creative ALchemy, you can: Playing MP3's via Winamp was more successful however audivy there was a genuine improvement in audio quality when listening to the audio via my Sony AV amp and speakers compared to an SB Live!
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For more information go to www. I never had any problem with the sound and the quality is very good. The time now is Finally i am releasing an alpha of the kx driver mod, there are two ways to use it, with the installer pack and the kext only pack, i suggest the first option, says that, install it and test it on your machines and give me feedback.


text:
Mark Winborn eBooks
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Deep Blues: Human Soundscapes for the Archetypal Journey
Mark Winborn
Fisher King Press, April 2012
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Award-winning firm of Consulting Engineers providing professional quality services in all areas of construction across the country since 1972. Our 80-strong staff team is based at offices in Sheffield and Fleet.
Our Projects
We have been the structural engineers for the nearly completed Derbyshire Eco Centre for the past two years.
The Eco Centre and surrounding landscaping has been designed to target an 'excellent' standard from the Building Research Establishment Environmental Assessment Measure (BREEAM). It has been built on a reclaimed lead mine and stone quarried site using sustainable methods, materials and technology.
The project involves the construction of a ten storey steel frame teaching block with a seven storey glazed atrium, a four storey concrete frame catering block and a four storey steel frame sports hall block on the site of the existing Castle South Campus. There is also a single storey extension on top of an existing two storey loadbearing masonry building and a single storey nursery building.
Docklands High-Rise Residential Complex
The 5 new buildings of 10 and 18 storeys were awarded 'Best London Development' by the Daily Mail UK Property Awards, 'Best Apartment' and 'Best Interior Layout' by the What House Awards, and shortlisted for the 2006 Housing Design Awards. We designed the foundations, structural frames and drainage on all five buildings.
7 Storey Residential Development
The development has 59 flats in a block which is up to 7 storeys high. There is a full basement car park, with contiguous pile walls along two sides.
Eastwood &Partners were appointed by Citygrove Securities Limited to give civil and structural engineering advice for a retail unit on the remediated former Maidstone Gas Works, immediately alongside the River Medway.
Eastwood and Partners are carrying out the structural checking on the 'Shard of Glass', which will be the UK's tallest building. The completed structure will be 302 m high, including a hotel, office space and residential lettings on a total of 74 floors.
Conversion of 18th Century Listed building into luxury flats
This 18th century Listed building with later extensions by Lutyens is to be converted into 24 luxury flats, with a further 5 large houses in the grounds, and an underground car park.
We're here for you.
Whether you need just one of our engineers or a small army of them working for you, we have the skills and expertise to deliver projects large and small. Our team of Directors, Associates, Engineers, Graduate Engineers and Technicians specialise in civil and structural engineering, the design of structures, and foundations in difficult ground conditions.
We have completed over 40,000 jobs for our clients and we are proud of every one.
Whitwell Sewage Treatment Works is a new plant designed to serve a population of 5,500 for Severn Trent Water. North Midland Construction were the Principal Contractor and E&P undertook the civil engineering and hydraulic design for the project as part of the design/construct team.
E&P are undertaking the civil engineering design for the project, based on a notional design prepared by the Client.
Three large storm water retention tanks are being constructed for United Utilities by North Midland Construction at Southport Waste Water Treatment Works. The tanks are 42 metres diameter and will be used for the temporary storage of excess storm water to a depth of 9 metres, supplementing six existing tanks.
Contact Us
Sheffield Office
0114 255 4554
Fleet Office
01252 360 580
Alternatively, contact us via email here.


text: Hemant Kumar, Kumar s Old Hindi Songs, Best of Film Songs 50 s, 60 BollyMeaning is the only website for Correct Lyrics with English Translations and Meanings Bollywood Words, phrases terms mukesh. The Mehndi Laga Ke Rakhna lyrics from 'Dilwale Dulhania Le Jayenge', starring Shahrukh Khan Kajol in lead roles ab laut chale (jis des main ganga behati hain) by: lata mangeshkar, mukesh manak who also wrote punjabi song. Directed by Aditya Chopra, music has akhan utte tere sajjna. Check out latest Bhojpuri song Heer Teri Judai Me sung Khushboo Tiwari jaayein tujhe kahan hawayein translation arijit singh pritam kamil srk imtiaz ambarsariya fukrey-2013 sona mohapatra hit taru jalpari jaisan featuring dinesh lal yadav neeta dhungana. are penned Irshad Sikandar is neel kamal singh. Learn-Sing Share-Lyrics Tunes Of Punjabi Wedding Songs- Ghori-Suhaag-Giddha Boliyan Te Tappe-Dholki de Geet-Doli Vidhayi De geet-sitthniyan Chhundd Ram Kare Aisa Ho Jaye movie Milan-1967 Lyricals, Sung ,Hindi Lyrics,Indian Movie Lyrics, Song Aake sidhi lagi dil pe jaise Katriya o saawariya oye Aaake hoye O teri tirchhi nazriya aa gayi mera julmi Kali Palak Do Chor (1972), | Latest Lyrics of. : Sameer sameer anjaan (born 24 february 1958) an indian lyricist, writing primarily songs language films. Lets Rock Now Soniye Bhool Bhulaiyaa Aankhon se lad aankhein, baaton badh baatein Mujhe rab ki kasam, rang laayengi sanam meri he a guinness world record holder the. to Prada Jass Manak: Gori Jatti Ghumme Bentley Ch Kaali / Ve Tu Hooli Ghar Mana Li Dil Nede Aa Dekh Lae Har Saah Utte Naam Bolle Tera Kehna Hi Kya Lyrics: Gumsum gumsum gupchup gupuchup gupuchup following incomplete list known have been recorded and/or performed mangeshkar malayalam languages. Hulchul hulchul ho zingaat dhadak: viral marathi "jhingat" film "siarat" gets its makeover original composers ajay-atul. Tags: Gori, teri, lyrics,


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Accident blocks traffic near the Indiana-Michigan state line
Posted: Apr 15, 2012 7:33 PM EST | Updated: Nov 5, 2014 9:53 PM EST
NILES TOWNSHIP, Mich. -- Three people are recovering tonight after a two car accident near the Indiana-Michigan state line.
It happened around 4:30 p.m. Sunday on State Highway 51 outside Niles Township.
Police told us the grey car appears to have crossed the center line. That grey car crashed into a black pick-up truck traveling north into Michigan.
Three people were transported to local hospitals with non-life threatening injuries.
The crash remains under investigation.
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Heavy downpour in Nairobi leaves city residents stranded - March 15, 2018
Heavy downpour in Nairobi leaves city residents stranded - March 15, 2018
School girls relief as they get alternative towels that can last two years - March 14, 2018
Past realignments: Past political maneuvers by Odinga - March 14, 2018
Cheating or not cheating I HNH 984 - March 14, 2018
Nakumatt creditors reject administrator's proposals - March 14, 2018
Farming activities commence in Mt. Elgon region after insecurity - March 14, 2018
Nasa principal Kalonzo Musyoka now wants to meet President Uhuru Kenyatta - March 14, 2018
Kerosene & diesel prices up by 70 and 90 cents respectively - March 14, 2018
Kenya Railways to invest on last mile for SGR - March 14, 2018
Fuel, alcohol prices to rise following annual adjustment of inflation tax
You might need to readjust your entertainment budget this financial year because the cost of your favourite local alcoholic drinks, cigarettes and even refreshment drinks is set to rise.
Subscribe to NTV Kenya channel for latest Kenyan news today and everyday. Get the Kenya news updates, discussions and other exciting shows.
Website: ntv.nation.co .ke || Paper: Daily Nation || Twitter: @ntvkenya || Facebook: NTV Kenya || Instagram: NTV Kenya


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Middle School Romance: The Pros and Cons - iMom
choice where both options have comparatively significant pros and cons. .. Many smart rich guys are rich because they don't let the women have One of my co-workers is a young woman with a child, she left the father. Dating, going out with, or being married to a "strong woman" is not for the faint of heart. Deep stuff but we will leave that for another time. ◊♢◊. Downside of dating a beauty: If a woman's more attractive than her Men trying to go out with women who look like Anne Hathaway (left) or.
The first and, probably, one of the most cherished benefits is the lack of commitment to marry. As a rule, the basis for this relationship is not a high sense of love, so the woman will not demand the creation of a marriage union, she has it already. You will have a diverse sexual life.
Firstly, married women have more profound knowledge in the intimate sphere, and secondly, any woman always seeks to surprise and please her lover, which means that each of your meetings will be like the last one: Besides, you can satisfy your bold intimate fantasies and try sex in unusual places, role-playing games or sex toys. Conspiracy in these relationships is the main thing, and therefore, she will not pursue her lover.
That means that you live the life you want, you do not need to change anything, and you act as you want without fear of claims from her side. Hence, she will try to do everything to make the relationship remain secret. This is already a significant plus. Another positive side of such a love affair is that a married woman does not demand to marry her. Sometimes, of course, it happens, and they demand, but they do that much less often than unmarried women.
She is less demanding.
How to date a married woman? In some cases, it is quite easy. In addition, you show yourself as a sensitive and delicate man.
You do not call her often for the same reason. The great thing is that she will not make calls without any reason as well.
Dating a Loser? 6 Reasons You Can't Leave Him
You have fewer chances to have a venereal disease. The risk of getting such a disease is minimized in a relationship with a married woman. She will not change partners three times a week, and will not have sex with the first comer.
After all, she has a husband.
- There's no compelling reason not to start dating again
- Add Comment
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You can easily break up. This relationship is built without mutual oaths and promises, you will have nothing to share, so you will need to have one conversation to break up forever.
Middle School Romance: The Pros and Cons
The main thing that you should remember is that you need to do that with a sense of dignity and tact, remaining a man and a person. The Main Drawbacks Possible exposure. You should remember about that. Not every husband will calmly and adequately perceive information that his wife is cheating. In most cases, he wants passionately to deal with the person who has seduced his wife, and not only with words but also with active physical actions.
So, either learn a self-defense or how to run fast. You get tired of it pretty quickly. And if it causes pleasant excitement at first, then it will grow into irritability and discontent. You are not the only one who has sex with her. It's hard and very unpleasant, especially in cases where a woman is really dear and pleasant to you.
Problems in creating your own family. If a man wants to have a full-fledged family, then this option will not work. You are wasting time. Some men have similar relationships for years, and they get used to that so much that they are not able to create their own families.Dating Women with Children: Pros & Cons
To wait when your beloved one will leave her husband is also not the best prospect. Besides a showdown with her husband, you can become the epicenter of all subsequent problems for a woman: All that can bring a lot of unpleasant moments and worries.
Nobody is immune from the fact that his married mistress will not turn into Fury who will want to break up with her husband and legitimize her relationship with the new lover. It's not the happy end. It happens that a woman leaves the family for a lover, but, unfortunately, this does not bring happiness. As a result, everyone loses: The person responsible for the breakup of her past family feels not the best way, at the same time, it turns out that the lives of at least three people are ruined.
What about an ethical aspect? Such a relationship is illegal from the moral point of view. If you are free and have sex with anyone, then it's normal, but you should still pay attention to the "occupied" girls who are really the other men's women. To have a relationship with a married woman is an indicator of a total disrespect for the man, and inability to keep yourself within some limits.
Among other things, you destroy other people's lives and the marriage of two people. Becoming a father at a later age can also provide you with an opportunity to stay young and active.
Dating a Loser? 6 Reasons You Can't Leave Him
What are some of the disadvantages of marrying a younger woman? She might get bored with you Sure, you offer financial security. You might get bored with her As incredible as this may sound to you now, in the future, you may find yourself bored with your young wife. Your shared cultural references are not the same. Your musical tastes differ greatly. She probably has little idea how to budget her money.
Her immaturity can become annoying. Do you fear they think that you are her sugar daddy, that she is only with you for your money?
For the first time in your life, you are insecure about your ability to keep your wife happy. You find yourself feeling jealous, and this is affecting your relationship. Having a younger wife makes you feel older You wanted a younger wife so you could feel young.
But actually, it makes you feel old. When you were first dating, her high energy and bubbly nature rubbed off on you, and it was easy to keep up with her as you rode the adrenaline rush.
She made you feel young again, and you loved that feeling. But now some time has passed and the unavoidable signs of aging cannot be ignored. You are out with her friends and you realize that you are the only one in the group who remembers where you were when JFK was shot, because her friends were not even born then.
Overall, regardless of the age difference, all relationships are the same.
If your relationship is based on love, trust and good communication, you and your younger wife will be just like any other happy couple. Enjoy each other; that is the most important thing.


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San Francisco State University
Department of Decision Sciences
Assistant Professor – Data Analytics
San Francisco State University, Department of Decision Sciences offers an exciting opportunity for a tenure-track Assistant Professor position beginning August 2020. We seek a colleague whose teaching and research interests include data analytics, operations management or statistics. We are especially interested in qualified candidates who can contribute, through their research, teaching, and/or service, through diversity, to the excellence of the academic community.
The Department of Decision Sciences resides within the AACSB-accredited Lam Family College of Business, which serves over 5,000 students. Current topics of instruction include operations management, statistics, forecasting, simulation, management science, quality management, project management, supply chain management, and data analysis/data mining. We have recently begun to offer an MS degree in Business Analytics, and emphasize applications within the business environment in all courses.
The mission of San Francisco State University is to create and maintain an environment for learning that promotes respect for and appreciation of scholarship, freedom, human diversity, and the cultural mosaic of the City of San Francisco and the Bay Area; to promote excellence in instruction and intellectual accomplishment; and to provide broadly accessible higher education for residents of the region and state, as well as the nation and world. To fulfill its mission, the University is committed to the following goals:
Responsibilities: The position requires undergraduate and graduate teaching in data analytics, operations management or statistics, mentoring and advising undergraduate and graduate students, developing an active ongoing program of scholarship and publication in one's area of specialty, and ongoing committee and service assignments. Detailed position description is available at http://cob.sfsu.edu/faculty-job-opportunities/full-time.
Rank and salary: Assistant Professor, Salary commensurate with qualifications and experience. The California State University (CSU) provides generous health, retirement and other benefits.
Application process:
Submit letter of intent/interest, a current CV, a statement on how your teaching and scholarship align with the commitment of the Department of Decision Sciences to foster an inclusive and diverse academic community, and names and contact information of three references. Letters of recommendation will be upon request at a later date. Submit all materials online to the DS Search Committee at firstname.lastname@example.com by October 31. Review of applications will begin immediately and continue until the position is filled.
San Francisco State is an Equal Opportunity Employer and does not discriminate against persons on the basis of race, religion, color, ancestry, age, disability, genetic information, gender, gender identity, gender expression, marital status, medical condition, National origin, sex, sexual orientation, covered veteran status, or any other protected status. Reasonable accommodations will be provided for qualified applicants with disabilities who self-disclose by contacting the Senior Human Resources Manager.


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Politics Isn't the Only Barrier to Real Tax Reform. Mihir Desai, November 15, 2017, Opinion, "In the annals of U.S. tax overhauls, 1986 is the modern guidepost. That was when a Republican White House joined forces with a divided Congress to modernize and simplify the U.S. tax code, cutting taxes on most Americans and raising them for some powerful interest groups. It was the last piece of tax legislation to deserve the label "reform."" Link
Found 25 article(s) for author 'Mihir Desai'
Mihir Desai on "The Wisdom of Finance"
Mihir Desai on "The Wisdom of Finance". Mihir Desai, September 12, 2017, Video, "In 1688, essayist Josef de la Vega described finance as both "the fairest and most deceitful business…the noblest and the most infamous in the world, the finest and most vulgar on earth." The characterization of finance as deceitful, infamous and vulgar still rings true today – particularly in the wake of the 2008 financial crisis. But, what happened to the fairest noblest, and finest profession that de la Vega saw? De la Vega hit on an essential truth that has been forgotten: finance can be just as principled, life-affirming and worthy as it can be fraught with questionable practices. Today, finance is shrouded in mystery for outsiders, while many insiders are uneasy with the disrepute of their profession. How can finance become more accessible and also recover its nobility? " Link
Harvard Business School Professor Explains the Most Important Problem We Have In Finance Today And How To Fix It
Harvard Business School Professor Explains the Most Important Problem We Have In Finance Today And How To Fix It. Mihir Desai, June 5, 2017, Video, "Mihir Desai, a professor of Harvard Business School and the author of "Wisdom of Finance" explains why having shareholders who are separate from the managers hold great danger for finance today. Following is a transcript of the video." Link
The Wisdom of Finance: Discovering Humanity in the World of Risk and Return
The Wisdom of Finance: Discovering Humanity in the World of Risk and Return. Mihir Desai, 2017, Book, "In 1688, essayist Josef de la Vega described finance as both "the fairest and most deceitful business . . . the noblest and the most infamous in the world, the finest and most vulgar on earth." The characterization of finance as deceitful, infamous, and vulgar still rings true today – particularly in the wake of the 2008 financial crisis. But, what happened to the fairest, noblest, and finest profession that de la Vega saw?" Link
The Debate on Corporate Tax Reform Just Started for Real
The Debate on Corporate Tax Reform Just Started for Real. Mihir Desai, May 2017, Opinion, "President Trump's announcement of his proposed tax reforms, as skeletal as it was, is better news than most commentators have suggested. First, it signals that the administration is coming to the view that tax reform is the most important agenda item for the first term — and that is great news. Second, the fact that the corporate piece of the proposal did not embrace the plan proposed by House Ways and Means Chair Kevin Brady and Speaker Paul Ryan, and its so-called border adjustment tax, is also good news. So, there is some good news in what it signals and what's not in it. What about what is in it?" Link
Problems Unsolved and a Nation Divided
Problems Unsolved and a Nation Divided. Michael Porter, Jan Rivkin, and Mihir Desai, September 2016, Paper, "America retains and enjoys many strengths. However, various economic indicators show that the U.S. economy has failed to deliver strong growth and shared prosperity for nearly two decades. These structural issues pre-date the Great Recession and are compounded by political paralysis. This report calls for a national economic strategy for America and proposes federal policy priorities that can form the core of such a strategy. Further, the report highlights corporate and personal tax reform as a promising first step in the strategy. Finally, the report warns that it is impossible to solve the issues besetting the U.S. economy and bring prosperity to millions of Americans if the United States remains mired in crippling political gridlock and vicious rhetoric." Link
Interest Deductions in a Multijurisdictional World
Interest Deductions in a Multijurisdictional World. Mihir Desai, April 2015, Paper. "This paper proposes and evaluates alternative methods for addressing the tax treatment of interest expenses in a multijurisdictional setting. The differential deductibility of debt entailed by various current tax law provisions leads to potential distortions in the patterns of asset ownership across MNCs and various proposed solutions have significant limitations. We suggest alternative regimes – a worldwide debt cap (WDC) and a net financing deduction (NFD) – to address the ownership distortions that we highlight along with other well-established problems of income-shifting through debt…" Link
Competitiveness and Tax Policy
Competitiveness and Tax Policy. Mihir A. Desai, February 2015, Paper. "In an age of economic anxiety, dramatic changes in the global economy have unsurprisingly received increased scrutiny by policy analysts and the broader public. These changes have become inextricably linked to concerns over the place of the U.S. in the world economy. In short, 'globalization' has given rise to concerns over U.S. 'competitiveness' and policy makers are encouraged to act on these sentiments. Unfortunately, there is little common understanding of what these terms mean, providing little guidance for analysts and policymakers called on to…" Link
The Conversation We Should Be Having About Corporate Taxes
The Conversation We Should Be Having About Corporate Taxes. Mihir Desai, August 22, 2014, Opinion. "The corporate inversion — when a U.S. company takes on the legal identity of foreign subsidiary, usually in order to reduce its taxes — has become about as controversial as corporate finance topics get. President Obama has called such transactions "unpatriotic." Others have defended them as a way for American companies to stay competitive in the face of a uniquely intrusive tax code. Harvard Business School's Mihir Desai and Bill George both fall mostly in the second camp, but with some surprising twists…" May require purchase or user account. Link
Getting a handle on inversion
Getting a handle on inversion. Mihir Desai, August 14, 2014, Opinion. "In recent years, a number of U.S.-based corporations with significant international holdings have shifted their headquarters overseas in an attempt to lower their tax bills. At 35 percent, the U.S. nominal corporate tax rate is highest among member nations in the Organization for Economic Cooperation and Development (OECD). The maneuver is known as tax inversion. Officials in the Obama administration have described it as unpatriotic, and are weighing an executive action aimed at limiting the economic benefit…" Link


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No.416 Jianye Road, South Jinqiao Area, Pudong, Shanghai, China.
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Wilson Elemenetary
Community Council Minutes
March 12, 2019
Community Council Minutes
March 12, 2019
Approval of Minutes
- Liz motioned
- Marion 2nd
- All in favor
STEAM Night
- People updated on the businesses
- Professionals and groups who are coming to present on March 26, 2019 from 5-6:30
- Liz motioned to approvepartial payment for microphones
- We will repair and refresh those for teachers.
Parent and Family Engagement Policy
- Liz motioned to approve the updated version of the Parent and Family Engagement Policy
- Marion 2nd
SIP Goals
- Math will be changed to 80% instead of 85% and also add a math fact goal to be reached.
- Reading will remain the same with 1 years growth in STAR test, with the addition of Sight Words for each grade that need to be passed off.
- Writing goal will remain the same with the change from Opinion wrting to Narrative writing.
- Art will remain the same with Sheree her involvement in each grad's Core Curriculum.
- Marion motioned to accept outlined SIP goals.
- Jessica 2nd
- Budget: $68,000
- $25,000 - 90 Chrome books for 3rd grade
- $8,000(+$2,000 supplies) BTSALP
- $2,700 Software for AR
- $8,000 Instructional Assistants
- $23,000 Possible Math Facts Implementation $23,000
- $21,000 Instructional Assistants (half hour for each teacher 1-5 timings)
- $1,300 set up math facts
School Evacuation Procedures
- Sue reviewed the School Evacuation Procedures
- In has been decided to present ID to enter and pick up the students.
- This would be good to notify and remind parents in a simple way that this plan will be put in place and to be prepared.


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text:
Chicago Actors Ensemble
at Preston Bradley Community Center
Suzan-Lori Parks's The Death of the Last Black Man in the Whole Entire World is far from a traditional play. A fragmented work composed of themes, variations, and repetitions, its structure is reminiscent of a symphony, though it uses ideas instead of music. Sometimes confusing and occasionally heavy-handed, it's nevertheless a fascinatingly complex work that redefines and stretches the boundaries of theater.
The experiences of slavery and the African diaspora have left many modern writers trying to hold on to a history that's been taken away from them. Like August Wilson's Herald Loomis in Joe Turner's Come and Gone, who's been an aimless wanderer ever since he lost his song, the characters in Parks's play represent figures of a disappearing history. Their stories are told in bits and pieces from which the audience must reconstruct the past. Nothing less than an attempt to tell the histories of Africans and African Americans and to recount the difficulties of reassociating with one's past, Parks's work uses a variety of historical and folkloric figures to recall slavery, discrimination, and the world of Africa before colonialism.
The characters in this play sit at the back of the stage with watermelons in front of them as individuals stand up to recall fragments of history. A man in chains and straps pleads with the others to remove his shackles so he can move his hands. A woman recites the words "prunes and prisms" over and over so that her "big lips" won't get in the way of her ability to pronounce words as white men tell her she's supposed to. An African queen recalls the regal history of blacks in Africa, while a television reporter speaking into a microphone made of pencils continually tells the audience to write down everything they've heard so they won't forget it and history will be preserved. All the while a figure named Lots of Grease and Lots of Pork holds a newspaper aloft whose headline informs us that we're about to witness the "death of the last black man in the whole entire world."
These disparate words and images form a framework around scenes of Black Woman With Fried Drumstick carrying on conversations with Black Man With Watermelon, who has been lynched and carries around the tree and the rope with which he was hung, begging people to loosen his collar. He recalls swinging back and forth from the tree while people with picnic baskets watched. He decries the indignity of hanging from a tree instead of a scaffold. "Trees come cheaper," we're told. Meanwhile the woman hurls eggs into a bowl, counting them as they splat, and when she makes a sour face and says "Oh, whiff it" she could be referring to the smell of the eggs, the smell of the dead man beside her, or the smell of the death of history itself. Most likely she's referring to all three.
It's a tribute to Parks's command of language that many of the statements in her play can be interpreted on a variety of levels. When some of the figures tell us "Something's turning--the page," we're faced with the literal meaning and with an image of something that's changing, with a new consciousness of history. When Black Woman With Fried Drumstick tells Black Man With Watermelon she will "plant him" in the ground, Parks allows us to see images of both death and rebirth. The death of the last black man in the whole entire world is both literal and metaphorical; it refers to the man we see wandering with the noose around his neck, and it also refers to the death of history.
The superb Chicago Actors Ensemble cast and energetic direction by David K. Smith bring the richness and power of Parks's work to life. Though the ideas in the play are sometimes disjointed and repeated too often, this is so imaginatively written, so well performed, and so filled with compelling lessons and intriguing metaphors that it will reward those patient and open-minded enough to listen to what it has to say.
Art accompanying story in printed newspaper (not available in this archive): photo/Tony Martin.


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It just happens to be the last driver that loads while the text-mode driver list is displayed on a "safe mode" boot, so people blame it even though a later part of the boot porcess is hanging. It's a common Windows Vista problem. When promted hit "next" until you see the choice to "Repair Computer" and select it. The original file has been signed by a trusted signature authority. Once logged on replace damaged files with sfc etc etc. Monday, June 30, 1:
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None of the above where there to be found. Proposed as answer by Coffee-guy Wednesday, July 7, 5: No pc expert, and quite by accident, but all data intact and ready to roll. Microsoft needs sued for putting out such a defective product.
So filterr reboot, mess around with some other things, tried to boot up, still a nogo. This software is produced by Microsoft www. Apparently the crcdisk check looks at all hard drives mounted on the system.
And all seems to work fine so far 2 hours with multiple boots and iflter. There is no detailed description of filte service. I don't think it was more than an hour. Since the error is unspecific and there does not seem to be more detailed information on the specific routines performed by this driver, I cannot speculate on the precise challenge that this driver seems to be encountering when it hangs. Looks like a totally different type problem that most here are discussing.
I also had an external drive attached and initially when I removed all USB connections that worked to get Windows reinstalled. I might just fliter a Mac. The laptop then spent 30 minutes "doing things" and rebooted.
Then I replaced the old drive crdisk the new one and the system booted up immediatly. I'm the type of tech guy that "beats the odds" frequently, and I can fix something by trying several different strategies.
It was not until I installed a new hard drive and used the USP port to access the bad disk that I was able to get at it. Running checkdisk fixed a lof errors, especially security permission ones, but still couldn't reboot.
I don't have a Vista disk since the computer filtr with Vista. After restart I couldn't boot, because system files were said to be missing.
Reboot into Normal Mode.
I did attempt this process and it was not successful. I had a similar problem no hardware problem but in my case only a clean installation did it. Any of the safe mode options filteg in it stopping at crcdisk. I had just built the computer a couple of weeks ago, and it just started doing the same exact things listed here.
The system restore is then the best option.
Hope you don't mean you are not going to do any more updates. Booted up on the new drive.
Friday, June 18, 5: The system hangs on CRCDisk. First when I received my friends computer he said he had a virus on it, so i opened it up looked at it, and nothing out of the ordinary seemed to be happening, so i just proceeded to start with the basics, and it needed a Vista update SP1 which i thought to myself wow thats old why is it just now finding that update Replied on March 20, After installing the Auto Update on my laptop, the system rebooted and stopped right after the green loading bar.
We've identified everyone has this issue


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Sunday, January 5, 1997 The Arizona Republic T13 lb advertise ' or f rtfer information about this bannered page j please call 440-4751 -l rI fiO ftay at t Impsrial for. To advertise on these pages or within other RepublicGazette gaming sections, contact your account executive or call the newspapers at ' (602) 271-8443. Spectacular rate offered during selected dates -a The best deal In Las Vegas is at the Imperial Palace Hotel and Casino, in the heart of the action-packed Las . Grand Opening 19-story hotel with 850 rooms. Also in that year, on Dec. 1, the world-famous Imperial Palace Auto Collection opened on the fifth floor of the hotel's parking facility. More than 200 antique, classic and special-interest vehicles began the reign in " the plush, gallery-like setting. . In 1981, another innovation took place under Engelstad's direction. He Instituted the Senior Citizen Christmas Party, an annual event, which provides low-income senior citizens and non-ambulatory convalescent center residents with a complimentary holiday dinner and show. A A year later, in August, 1982, the . number of hotel rooms Increased to : 1,500. ... ; . : The covered parking garage was expanded early in 1985 to accommodate over 1,000 vehicles. . During the 1 986 expansion program, meeting and convention facility space ; was increased, hotel rooms increased to 2,100 with the completion of Tower IV, and an additional 15,000 square feet of space was added to the casino. A three-phase expansion project began in August of 1987, and was completed in . lull 1QPQ Special January 2 thru February 13 uai iuoi y c r '.it Single or Double Occupancy Sunday thru Thursday Subject to availability Extraordinary Extra-Large Guest Rooms Home to the multi-million dollar stage extravaganza, "Legends ' -In Concert," and the world-famous Antique and ' Classic Auto Collection, the.. Imperial Palace 0ers the best in entertainment, dining and hospitality in Lis Vegas. Engelstad built some low-rise buildings on the site and employed a staff of 250. Gaming began at the Flamingo Capri a year later in 1972. In 1974, the East and North buildings opened, along with the addition of the Shangri-la pool. On November 1, 1979, the beautiful casino of the Imperial Palace opened and the number of employees grew to 1,000. Engelstad selected an Oriental theme for its originality and personal appeal. Influenced by Japanese temple architecture, Merlin Barth, architect, specified traditional blue tile imported from Japan for the roof. The Oriental theme was carried out in-side as well, influencing everything from , decor to food service and employee uniforms. In the casino, carved dragons and 1 giant wind-chime chandeliers complete with gaming tables for the visitors' attention. ; Entertainment began in the Imperial ; Theatre showroom in June, 1980. The showroom seats 850 and since its opening has featured top stars as well as exciting revue shows. Its use was also expanded as a site for taping sports and entertainment television specials for network and cable TV broadcast By 1981, the Imperial Palace was a "Gone Country"Extravaganza starring Rex Allen Jr. Vegas Strip. The resort otters rooms for ! just $10 per person, based on double oc- cupancy, for the "January Spectacular," Jarr. 12-16 and 26-29. These fabulous deals automatically in: . ! elude a free buffet; a $1 0-off dinner cou-J pon for the delicious Fifth Floor Dining ' J Plaza restaurants (except Pizza Palace); ' free Scratch Slotto Card, with a chance to win up to $5,000 instantly; free Ippy's 24-J hour Fun Book,' which includes dozens of J free and discounted specials; plus a free $200 value toward earning redemptions : in the Imperial Players Club (initial enroll- .Imentsonly). , J Home to the multi-million dollar stage extravaganza, "Legends In Concert," and the world-famous Antique and Classic ! Auto Collection, the Imperial Palace offers J the best in entertainment, dining and hos- pitality in Las Vegas. The "January Spec-! tacular" specials automatically include free admission to the Auto Collection and ; $6ff a "Legends In Concert" show. 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