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This story contains discussion of sexual harassment, sexual assault & institutional betrayal.
Sexual assault and harassment policy at ANU has major flaws in reporting options, communication, support for survivors, and mechanisms of discipline, according to a review published yesterday into the issue. The review was conducted in response to the Australian Human Rights Commission's survey published last August, which found that ANU had significantly higher rates of sexual assault and harassment than other universities. It recommends overhauling much of how ANU manages sexual harassment reporting and the correction of key failures of the current system.
This is a summary of the key findings and recommendations, with more extensive coverage to come.
Why this is happening.
Throughout 2016 the Australian Human Rights Commision (AHRC) conducted a survey into sexual assault and harassment on university campuses, asking a large sample of random students to relay their experiences with the issue. The results were not good overall, with more than half of Australian students facing sexual harassment or assault, and worse for the ANU, which was six points higher than the national average, double the national average in residential halls. Vice-Chancellor Brian Schmidt announced this review, conducted by independent firm Rapid Context, to examine the university's policies and procedures surrounding reporting of assault and harassment, how reports are handled, what action is taken, and how survivors are supported.
Criticism and controversy have followed the review already; it was criticised for not consulting survivors of sexual assault during its formation, rather relying on documents of past cases, a choice which was justified by an attempt to get the report done quickly – it was originally slated for mid-September.
However, the review did not make this deadline, and the Rapid Context review was instead published almost four months after the survey results. Notably, the review itself recommended consulting student survivors going forward.
What's in the review.
This review presents a perspective on ANU's policies on sexual assault and harassment reporting and discipline which are obscure, convoluted, and at times contradictory, creating a system which at best makes it difficult and at worst actively discourages students from reporting or seeking action on assault and harassment. The review identifies policy changes which could help address these issues, as well as improving support for survivors, making policies publicly accessible, and publishing anonymised results of disputes.
What happens next.
ANU has publicly committed to following most of these recommendations. If this goes ahead, we could expect to see movement on many of these policy recommendations in coming months. However, these are extremely large changes in an institution which is typically slow to affect any kind of bureaucratic overhaul. It would also require substantial funding – for instance, the addition of a centralised reporting coordinator would require substantial staffing and upkeep costs. The ANU has not committed to any timeline for these changes.
Observer will closely follow and report on the actions of the University administration following this review, and continue to update you with more details of the review in the coming days.
Please note that the following is a summary of the positions outlined in the review and not the editorial position of Observer.
Reporting sexual assault at ANU is hard. It could be much easier.
The review shows procedures for reporting sexual assault and harassment are convoluted and not well publicised. Currently students make reports to ANUSA, PARSA, their senior resident teams, the Dean of Students, the Counselling Centre, Access and Inclusion, or other staff and students. Many of these bodies do not have complete information about policies, and the review found some will view the report as "outside of their scope". This can lead to reports being dropped altogether, or can "create a bystander effect" in which no one institution feels responsibility to follow up the complaint.
The review advocates for the creation of a "one stop" coordination unit which students can contact for any issue; currently, different systems are in place for different types of issues. These services are largely not advertised, a concern the review also recommends addressing through publication on major student web interfaces and materials. The review also calls for the establishment of a 24-hour hotline so that students can immediately report incidents outside of business hours, and get immediate support services; however, ANU has said they will not implement this recommendation as it is "already being provided by existing services". One source familiar with the process said ANU was referring to the service 1800RESPECT which does offer this service.
The review notes the current absence of provisions to report anonymously: while some systems including most Senior Resident groups at residential halls do manage anonymous reports, there is no guaranteed option in reporting policies for an anonymous report, and the review recommends these be implemented. It also identifies that reporting procedures are currently incident-based, discouraging reporting a culture of harassment or an unsafe work environment in a general context. They are also built with the assumption that the individual affected is making the report, discouraging whistle-blowers or external observers to report incidents. The review recommends adding provisions for both these reporting options.
It's unclear whether ANU can or will act on sexual assault.
ANU has a Discipline Rule, a document outlining procedures for disciplining misconduct. However, the review notes that the Rule, and other policies, don't clearly state whether they can address sexual assault and harassment, through which policy an incident should be managed, or who should manage a complaint.
This creates confusion over how a dispute should be managed: the review found that ANU policy on police referral is "at best, unclear". It then argues that if the intent is to go to police, ANU's role should be to support the survivor and gather information. If the intent is to make an internal disciplinary action, however, then ANU should actively investigate and have a process of determining punishment. This lack of clarity, the review finds, leaves many students unaware of whether ANU can or will address the issue. The staff who are supposed to help are often also confused; a confusion which is "exacerbated by information currently provided by the ANU", or a lack thereof.
The review also refers to findings in the AHRC survey that "a common response by universities to disclosures of student sexual violence is to frame the issue as a police matter" by claiming the University can only act "once a police complaint is made and/or conviction secured". While the University does not have a clear policy detailing when and how they can act, it's certainly not clear they can take no action without conviction; the review says that ANU can take action, but that it is a "question of both law and principle and it is one that only the ANU leadership, in consultation with its community, can determine". The review goes on to claim that determining how "ANU can and will act to address misconduct related to sexual assault is, in our view, a matter of urgency".
Resolution of disputes is arbitrary, and students are kept in the dark.
ANU also has no clear policy on what procedure should be followed in the resolution of a dispute. The Discipline Rule and the Complaint Resolution Procedure, which is for non-disciplinary action, specify different resolution procedures, and it's unclear which incidents fall under which process. Neither process has specific guidelines for managing sexual assault or harassment.
The review advocates for mediation – that is, discussion between perpetrators and survivors to attempt to resolve an issue – but makes clear that an overarching structure should be established to ensure that only low-level incidents go to mediation. It also argues that this process should be informed by the trauma of the student, and criticising the current mediation process, saying it "does not appear to acknowledge that some students who have complaints may be traumatised by their experiences". This change would mean students engaging in mediation on their own terms and in ways not potentially detrimental to both their short- and long-term wellbeing.
More serious incidents, the review says, should be actively referred to police. This process should also be governed by a broader policy on when issues are worthy of police consideration however – having this provision be arbitrary leads to the issue of avoiding responsibility by citing the role of police as discussed above. It also notes that over-reliance on student peer networks, like Senior Residents, in sexual assault and harassment reporting does not provide "clear pathways" to police reporting and so students do not report. The review recommends "warm referrals", where the referring officer from ANU would actively put survivors in contact with police and external support.
Students who report should also be given far more information about their case, the review says. Currently, ANU has no obligation to return any information on the process of the report, to resolve the report in any given time frame, or even to provide students with the results of any dispute. The review recommends all these steps be required.
Survivors need much more support.
The review identifies that many students or staff who report sexual assault or harassment undergo severe trauma, both from the incident itself, and from the process afterward. It notes a frequent lack of referral to formal support services, or the provision of insufficient or incorrect information. Specifically the review noted that many students are told, even by those who are supporting them, that services like the counselling centre are "impossible to get into" rather than providing accurate information on how best to navigate the system. The review stressed that services themselves are in fact severely limited, and that these limitations "appear to be largely due to a lack of funds, not from willingness of support staff to do more".
As well as students who have experienced sexual assault or harassment, there is a significant need for support among those who assist or manage these reports, especially among student groups. The review found an "overwhelming sense of distress and frustration" for those assisting students on a regular basis, especially as some of these individuals are survivors of sexual assault or harassment and are re-traumatised by the frequent exposure to discussions and details of sexual assault without adequate support themselves.
Training needs to get much better.
The review recommends disclosure training be implemented for "all students and staff in support roles" but also ideally expanded to "members of the broader ANU community." One option proposed by the review is to have a group of publically identified students with this training such that people capable of handing disclosure exist in social spaces across the university. Training should be culturally sensitive, the review says, taking account of the differing needs of "Aboriginal and Torres Strait Islander peoples, people of diverse genders and sexualities, people with disability and how these social and cultural characteristics intersect."
Particular attention was made to the training of Higher Degree Supervisors, owing to "concerns about potential power dynamics … making HDR students and early career researchers vulnerable to sexual harassment" due to the competitive environment. The training would consist of "mandatory bystander training and modules for Higher Degree Research (HDR) supervisors and convenors".
A database of all complaints, procedures and resolutions should be maintained.
The review recommends ANU publish the results of sexual assault and harassment disputes, minus the identities of parties involved. It advocated the university "consider regularly disseminating de-identified disciplinary outcomes reports to the wider university community."
It furthermore advocates for the creation and maintenance of a database of all reports made, procedures followed, and the eventual results. This would allow for accurate data on the number of reports made, and how many produced any kind of result.
Students have no faith in ANU.
There is a "complete lack of trust and confidence in the reporting mechanisms and failure on the part of the university in meeting their moral and ethical responsibility to make the campus safe" among students, the review says. It claims the general student population sees the reporting processes as ineffective or nonexistent, and the university as hostile, a perception it blames on the total lack of clear reporting policies or procedures. The review recommends the full transparency of clear procedures, and the active publication of these procedures, to address this deeply rooted mistrust.
Jason Pover contributed to this report.
If you have been sexually assaulted, or affected by a sexual assault, support is available:
Canberra Rape Crisis Centre: (02) 6247 2525 (7am-11pm)
ANU Counselling: 02 6125 2442 (9am-5pm, Mon-Fri)
If you want to participate in the investigative campus journalism of The ANU Observer, apply to join our team. No experience required, just commitment and tenacity.


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Lookup cumulative lexical entry: συνωνυμέω
- ﻡﺱ [sm]
- اسم (noun) Nicom. Arithm. yušārikuhu fī l-ismi
- شارك (verb III) Nicom. Arithm. yušārikuhu fī l-ismi
Translation process scheme for συνωνυμέω
Explanation: This diagram displays the translation process for one word, starting from the authors and their texts, which are then translated by different persons into different forms. To highlight all the connections of one node, click on one of the vertical bars.

subset: commoncrawl


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Yesterday, an early look at "Empire Magazine's" cover featuring Jared Leto as the Joker arrived online, and today, Leto's "Suicide Squad" castmate Cara Delevingne's cover has also been revealed.
RELATED: Jared Leto's Joker Struts in New "Suicide Squad" Images
Posted on Comic Book Movie, the image gives us the best look to date at Delevingne's character, the enigmatic Enhantress. Not much is known about the version the actress is portraying in the Warner Bros.' film, but Delevingne has described the villain as "two different parts." "I'm playing opposites a mousy kind of scientist and then a crazy, feral witch -- which is great. They're both sides of my personality, so that's nice."
"She's an ancient sorceress," Delevingne tells "Empire." "A feral being. She's been trapped for so long and now she's finally let out." The hapless human whom Enchantress takes over is June Moone, who finds more than she bargained for while exploring a creepy cave. "June is an adventure-seeker who's always wanted some excitement. And she gets what she wished for, in an terrible way."
"Suicide Squad," directed by David Ayer, arrives in theaters August 5, 2016.


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Discrete control systems
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A relatively simple approach to non-linear predictive generalised minimum variance (NPGMV) control is introduced for non-linear discrete-time multivariable systems. The system is represented by a combination of a stable non-linear subsystem where no structure is assumed and a linear subsystem that may be unstable and modelled in polynomial matrix form. The multi-step predictive control cost index to be minimised involves both weighted error and control signal costing terms. The NPGMV control law involves an assumption on the choice of cost-function weights to ensure the existence of a stable non-linear closed-loop operator. A valuable feature of the control law is that in the asymptotic case, where the plant is linear, the controller reduces to a polynomial matrix version of the well known generalised predictive control (GPC) controller. In the limiting case when the plant is non-linear and the cost-function is single step the controller becomes equal to the polynomial matrix version of the so-called non-linear generalised minimum variance controller. The controller can be implemented in a form related to a non-linear version of the Smith predictor but unlike this compensator a stabilising control law can be obtained for open-loop unstable processes.
The design of stochastic LQG optimal tracking and regulating systems is considered for discrete-time systems with different time delays in different signal channels. A Wiener frequency domain solution for the closed-loop optimal controller is first obtained in the z-domain. This solution is physically realisable but involves the transport-delay operator. A state-space version of the controller is then derived from the frequency domain results. It is shown that the state equation based controller includes a Kalman predictor and state-estimate feedback. This confirms that a form of the separation principle holds for linear systems containing different transport delays on input and output signal channels. The Wiener solution applies to multivariable systems that may be unstable, nonminimum phase and nonsquare. The process and measuring system noise terms may be correlated and be coloured or white. It is shown that for certain classes of system the optimal controller can be implemented using a combination of finite dimensional and pure transport delay elements. The main advantage is that the estimator is of much lower order than the traditional solution. The gain computation involves a reduced state equal to that of the delay free system and is thereby independent of the length of the delay. The state-space form of the optimal controller may be implemented using either a finite impulse-response block, or alternatively in a Smith predictor form. In this latter case it has the same limitation, namely the plant must be open-loop stable. This restriction does not apply to either the Wiener or finite impulse response state space solutions.
The modelling and H∞ control of discrete-time systems with uncertain parameters which can be represented probabilistically is considered. The polynomial based model structure is chosen so that high frequency lag terms may be introduced whose parameters have zero expected value. Similarly uncertain zeros may be considered. An H∞ controller can then be obtained which stabilises the nominal plant model and also provides a degree of robustness to uncertain poles and zeros.
A global convergence and stability proof is presented for an indirect LQG self-tuning controller which employs a stochastic approximation type of identification algorithm. A discrete linear single-input/single-output time-invariant stochastic system with correlated noise inputs is considered. The plant model need not be stable or minimum phase. The usual assumption that unstable common factors do not occur in the estimated plant model is replaced by a weaker condition. The first set of stability and convergence results presented in the paper are independent of the control law employed. These are then applied to the specific case of the LQG self-tuner. The control and tracking error signals are shown to be sample mean square bounded, prediction error convergence is demonstrated and optimal pole locations are shown to be achieved asymptotically. A persistency of excitation condition is not assumed.
The solution to a linear quadratic stochastic optimal control problem is obtained for a discrete-time system. The performance criterion to be minimised includes the usual error and control weighting terms but has, in addition, the norms of the sensitivity and complementary sensitivity weighting matrices. The conditions for optimality are derived in the time-domain and the Wiener-type solution is obtained by transforming these conditions into the z-domain. A polynomial system description is then introduced so that the controller may be expressed in terms of the solution of diophantine equations. This is a more convenient form for computation of the controller.
The solution of the l. q. g. regulator problem is given by the separation principle and involves a Kalman filter with the same dimension as that of the plant. It is shown that, for a class of systems where the input subsystem states are measurable, the Kalman filter may be reduced in dimension considerably. An example of a steel-mill shape control problem is discussed where the number of states required in the filter is halved. The proposed optimal system includes direct state-feedback from the measurable states, which improves the performance of the system and reduces the effects of modelling errors.The optimal controller for the discrete-time system is derived in the z-domain. The solution of the above multivariable regulator problem has not previously been obtained in this form. The z-domain controller is particularly suitable for implementation on a microprocessor or digital computer.


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In terms of the boiler there are a range of models in the marketplace to meet the requirements of various kinds of housing and family sizes. What's necessary is you choose the right boiler for what you'll need and ensure of using a Gas Safe registered engineer to put in the new boiler.
Many homes in the UK have ineffective heating systems, which is actually adding hundreds of pounds each and every year to the annual energy bills. Boilers are given ratings from A (the most efficient) to G (the least efficient).
One type of central heating boiler you should certainly consider is the combination central heating boiler. These don't require a water storage tank and instead can be hooked onto the wall or fitted in a small kitchen cupboard. They provide heat on demand and are suitable for homes without multiple bathrooms.
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Leicester has the tenth largest population in Great Britain, located in the East Midlands and lying on the River Soar. The city holds a lot of its Roman history, including streets, baths and a military outpost. With 40% of the populace made up from immigration, there was clearly a need for more housing, leading to plenty of modern day plans.
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Combi boiler Projects in Leicester in October 2019
We noted 11,894 requests for house quotations in Leicester. Of these quotation requests the number of combi boiler quotations in Leicester was 480. Quotatis would have been able to match these customers with as many as 4 suitable contractors who were available for work within Leicester at that time. Request a free house survey from trustworthy companies in Leicester.
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About Leicester
The pie chart directly below shows the UK's populace using regions. Britain's whole population is higher than 62 million, with the most significant percentage of inhabitants based in the South East, Greater London and North West regions. The table below the pie chart indicates the UK's populace in regions as a figure. As you can see, both the South East and Greater London possess more than eight million occupants, whilst Northern Ireland and the North East contain the fewest inhabitants.
Solar PV
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House prices
The UK property market has slowed down somewhat in the last ten years as more people prefer to stay put rather than relocate. This is primarily because of the significant costs associated with moving and people are choosing to build conservatories or change rooms in the house to get more space.
Number of House sales
The table below shows how many properties have sold in Leicester during the last seven years. The housing market is now in a slump, with numerous householders deciding to stay put and improve their property and not move. Improving your own home can easily see you add thousands of pounds towards the value and improves your chances of selling too.
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You can run and run and run but you WILL BE CAUGHT.
Well done to all for showing such diligence.
Excellent communication and adept utilisation of resources led to the arrest of an individual who accessed two residential premises with the intention to steal in the Heldervue area recently.
The individual entered the laundry room of a premises in Gardenia Street and stole a pair of slippers and Rally car wax and then moved on to Compacta street where he attempted to steal a bicycle from the premises.
The alert resident at Compacta street had a birds eye view of the culprit via his surveillance system and promptly pursued him. The culprit then abandoned the bicycle and fled the scene.
Our Control Room received a call from the Compacta street resident and Response Officers Reece & Jakes were immediately dispatched and they proceeded to comb the area.
In the interim,Shift Senior Agmat proceeded to the complainant and obtained a more detailed description of the suspect which he then transmitted via radio to all personnel.
In the interim, a call pertaining to the theft at Gardenia street was received by our Control Room and a radio broadcast was transmitted.
Client Services Manager Mr Thomas, who was checking surveillance cameras on a site in the vicinity, detected the suspect fleeing along the N2 in the direction of Macassar.
The suspect was viewed on surveillance abandoning the stolen goods from Gardenia street along the N2 whilst he attempted to make a desperate escape up the N2 in the direction of Macassar.
Mr Thomas then assisted with the search coordination and pointed our response officers in the correct direction.Response Officer Jakes managed to outrun and apprehend the culprit and detain him until SAPS Somerset West arrived and arrested him and liased with the complainant who was able to positively identify him.
Well done to the alert resident and to the entire Vetus Schola Team.
Great team work and adept linkage and lots of dedication and committment were the key ingredients that led to this arrest.


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JJ's Fusion Grille
Open 7 days a week, 11AM-10PM
Driving Directions:
Located in The Grove Plaza off of Aloma Ave, between Hall Rd/Howell Branch Rd and Old Howell Branch Rd. Our suite is between Jay Anthony Salon and Sprint.
About Us
We are a fast-casual Build-Your-Own style restaurant serving a delicious and unique fusion between Mexican and Mediterranean food. We pride ourselves on our healthy/made-from-scratch cuisine as well as our unparalleled customer service. Our mission is to positively impact our communities both inside and outside of our kitchens. We offer affordable meals, kids meals, and catering too!


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"Raistlin's Pawn part 3: City of Death": The synopsis for this issue has not yet been written.
Appearing in "Raistlin's Pawn part 3: City of Death"
Featured Characters:
- Sturm Brightblade
- Riva Silvercrown
Supporting Characters:
Other Characters:
Synopsis for "Raistlin's Pawn part 3: City of Death"
- Synopsis not yet written.
- No special notes.
- No trivia.
See Also
- Write your own review of this comic!
- Discuss Dragonlance Vol 1 7 on the forums
- Cover gallery for the Dragonlance series
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I don't feel true to myself for letting my blog fall so behind.
I wasn't being true to my baby by always trying to squeeze in time to blog.
I have to remember this stemmed from the heart and I will post when needed. I also plan to still continue to post a picture everyday until she's 1 year old.
She is six months on Friday.
Can you believe that?
Things are changing quickly. She's such a little person now. She's my best friend, she's a monster, she's so happy. We're constantly complimented on our happy, long-eyelash beauty. She's making a lot more noise now and she's officially sitting on her own.
I also wanted to blog about the fact that she's transitioning to formula. Although I breastfed her a lot today. I can't stress the amazing feeling of nurturing someone through your own body. It's so beautiful and fun. Our reason to transition, aside from the fact that she's had her two bottom teeth since she was five months old, is the fact that her and I do need to be a bit more independent. We're like glue. I feed her, put her to bed, walk with her and constantly hold her. I also need to make sure I'm helping the entire family. Phil's gotten a second job to help support us. Because of my career- I can easily pick up random jobs where I don't have to commit fill time but I can bring in some money. I have a meeting tomorrow night and she'll be with Phil. After an emotional transition and several failed attempts over a couple of weeks, I know she'll take well to her formula bottle.
We're going to have a busy summer traveling, seeing as many people as possible. We miss our family up north. It's so different how much more I wish we were closer because I just want to share Annabelle's every moment with my family. The hardest part has been accepting the fact that everyone still has their own lives. I'm finding time to escape technology and get more active with my baby. I'm making time to contact and visit people. I feel like I'm not being met halfway but maybe my expectations have changed. Now that I'm a parent I know there's so much more to do with your time...
Life is just a new gift everyday and I hope to continue sharing and inspiring everyone's daily lives through our blog.
LOVE: As mentioned, Phil has gotten a second job like a true champ to keep us on top. We really need to get our own place within a year or two. We're both clearing off debts so that's why I am open to work at this time. We've tried going out at least once a month. Last Thursday we hit Yorkville and felt like our first crazy summer together. So much fun. We're the same people- just complete as one with Baby Belle.
PR: Yes, I'm open to work but I love being a mom!! I had my first opportunity to help a friend write a book treatment. It turned out sooo good and I can't wait to share his book when it comes through!
Baby: What haven't I bragged about? She's happy, chatting, sitting, jumping.
Foods: She's been on rice (gerber) and oatmeal (heinz). All other food has been home made. Yes I got a Baby Bullet! I'm totally following that book so thus far she has had sweet potatoes, zuchinni, brown rice cereal( made a la PhillyD), green peas and green beans.


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Claudia Gabel
AbeBooks Seller Since 14 August 2015Quantity Available: 1
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About this Item
Bibliographic Details
Title: Elusion
Publisher: HarperCollins and Blackstone Audio
Publication Date: 2014
Binding: Audio CD
Book Condition: New
Edition: Unabridged.
About this title
Avoiding her recently deceased father's alternate-reality program when she is unable to contain her grief, Regan nevertheless defends the increasingly popular program from its critics only to uncover a disturbing web of secrets.Review:
Corporate intrigue and a dangerous venture into the virtual realm enliven the cliffhanger ending.--Publishers Weekly
Fans of near-future distopian stories are going to eat this up.--Voice of Youth Advocates (VOYA)
A tense read full of twists, mystery and romance. Be ready for a mind-trip! ELUSION will leave you breathless!--Sophie Jordan, New York Times bestselling author of the Firelight series and Uninvited
This series debut features a smart, surprising teaser of a plot that keeps readers off balance--in a good way--to the last page. An ingenious, compulsively readable cure for the blahs.--Kirkus Reviews
Alluring, tense and mysterious, ELUSION will pull you into its reality and you won't want it to let go. With plot twists you'll never see coming, you won't be able to turn the pages fast enough.--Elizabeth Norris, author of UNRAVELING and UNBREAKABLE
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Do you want to partake in this FUN marketing event w/ Jenessee click HERE and submit your (FIRST/MIDDLE/LAST) name and last 4# of you cell.
Meditation: The below meditation can be used by anyone who connects to the messages with in the above recording. Energy is interesting and just because something wasn't created specifically for you doesn't mean it doesn't apply to your journey. If you find cords of similarity between your experiences and the recording above. Please use the following meditation to bring yourself into more alignment.


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Call us to schedule your event today!
Located in Queens County, New York City, Queens Luxe Banquet Hall is a private event venue that captures the beauty and charm of the internationally diverse city of New York while bringing glamour and elegance to any gathering.
This handcrafted Italian stone building was created in 1968 to magnificent standards, and the attention to detail is evident in every aspect of the Queens Luxe Banquet Hall. From the breathtaking entry and majestic lobby through to our Grand Ballroom, your guests will be dazzled by the building's crystal chandeliers, gold crafted ceilings, and polished imported stone floors throughout. Our Grand Ballroom was designed to create a sophistication, glamorous ambiance and sheer elegance for any social or corporate event.
Queens Luxe Banquet Hall features captivating old world charm. Our ideal venue location is nestled in the heart of Queens and has been in banquet hall business for over 50 years. This newly renovated location is ideal for your next wedding or celebratory event. We will assure you the specific attention to detail and the devotion you deserve.
Our modern facility boasts old-world European charm and can accommodate functions in two separate rooms for separate 250 plus guests' events. Our stunning venue has seducing waterfall feature by the lobby with a grand rotating chandelier that will charm your guests upon entry. The Grand Kingston Ballroom is can comfortably hold up to 275 seated guests and the Princeton Ballroom is can accommodate upto 250 guests.
Queens Luxe Banquet Hall is a premier choice for hosting any celebration. Your special occasion deserves the special attention to detail that Queens Luxe is renowned for providing. From a simple luncheon or dinner to an elaborate ballroom gala experience, we specialize in creating events your guests will remember for a lifetime. We have dedicated, professional staff who will help you make your event memorable and unique at an affordable price.
We invite you to visit our beautiful venue, and work with our skilled team who will guide you through our wide range of menu options to create a custom culinary vision for your special event!


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Weigh the pros and cons of technologies, products and projects you are considering.
IT Ops Implications of Continuous Delivery
The DevOps paradigm shift: Avoid obsolescence in IT
DevOps is an appealing paradigm shift in IT, part and parcel with app componentization and containers. But despite the hype, IT pros still face a few hurdles to actual implementation. Continue Reading
Prepare for ITIL framework updates in version 4
The much-anticipated release of ITIL v4 not only changes the framework's certification structure, but emphasizes many modern software development and IT service delivery practices. Continue Reading
Evaluate the COBIT framework 2019 update
ITSM frameworks must adapt as IT changes swiftly or risk stagnation. COBIT ended its six-year silence with its 2019 update. Get an overview of the new information and how to use COBIT. Continue Reading
Evaluate the Mesos architecture for massive container deployments
In addition to supporting large-scale IT deployments, Mesos takes a unique approach to data center and cloud resource pools that can benefit both containerized and noncontainerized apps. Continue Reading
IT organizations anticipate DevOps evolution in 2019
DevOps shifts around like ice cubes skate across water: quickly and always toward its outer limits. Kurt Marko explores some areas where DevOps will go in 2019. Continue Reading
Compare Go vs. Python for infrastructure programming
Both code languages get the infrastructure-as-code job done, but each from a different angle. This comparison tutorial puts their similarities and differences center stage.Continue Reading
Is 'Continuous Delivery with Docker and Jenkins' right for you?
If your IT organization is ready to bring DevOps from mindset to tool set, containers and CI/CD are probably on the agenda. See what you'll learn from Rafal Leszko's book on Docker and Jenkins to advance a pipeline project.Continue Reading
Cisco roadmap plots course through clouds to DevOps future
From a Google Cloud partnership to API-based network data integration, Cisco showcased application hosting flexibility and DevOps process flows in its product plans at its annual conference.Continue Reading
Make IT improvements that benefit the business, not just IT
Simple automation and high-visibility monitoring buff up IT but won't notably affect the grander business. Strive to make improvements with benefits that outreach IT.Continue Reading
Integrate DevOps and containers with simple tool adjustments
Organizations with an established DevOps pipeline can migrate from VMs to containers without tossing out the entire toolstack. Focus on these steps to enable containers in production.Continue Reading
Explore Ansible for DevOps configuration management
The configuration management tool is adept at managing workloads across different infrastructure environments. This Ansible overview preps admins to automate apps and infrastructure.Continue Reading
The ITIL 2018 update better catch up to modern IT
When ITIL last updated, DevOps was in its infancy. In the face of rapidly evolving IT practices and technologies, ITIL 2018 must be powerful and usable for diverse IT organizations.Continue Reading
IT ops pros predict routes to DevOps efficiency in 2018
Operations admins have a lot on their plates already, and they'll pile on more in 2018. These IT pros and analysts share what's coming and how to handle it.Continue Reading
Evaluate ChatOps tools and bots for the right fit
ChatOps is still a niche in IT operations and DevOps shops, but organizations that have set it up love it. That means you should join the fun and give it a try. Here's what you need to know about ChatOps tools.Continue Reading
Shrink the DevOps tool stack and grow its power
Given an embarrassment of riches, DevOps teams must discover what they need from tools and how to pick and propagate a cohesive tool stack across multiple teams.Continue Reading


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So to sum up;
If all these latest local spotbeam tps. and beams on 119W meet their scheduled turn-offs.
Of the original 37 active spotbeam tps. into 28 spotbeams on T7S (not inc'l the one unused beam into a part of CO.). What will the total active spotbeam tp./beam count be down to by 10/15?


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Xinjiang Best Culture Tour
If you have limited time, and want to see the most important parts of Silk Road in Xinjiang, we recommend you our 7 days itinerary, it contains the best parts of Kashgart, Turpan and Urumqi.
If you have limited time, and want to see the most important parts of Silk Road in Xinjiang, we recommend you our 7 days itinerary, it contains the best parts of Kashgart, Turpan and Urumqi.
To see better of Silk Road corners in Xinjiang, you required to have 12 days, here we have made you a wonderful itinerary of including all the necessary spots of the ancient Xinjiang.
China has long history, The Silk Road played very important role for communicating the civilizations between east and west, exchanging the products of Silk, Jade, spices etc..., please come and enjoy the cultures along the ancient path with us!
The Silk Road started from Changan, todays Xi'an, here in our country are a lot to see to understand the ancient Silk Road, you can realize it is not only a history, but also civilization, communication, exchanges...
North Xinjiang considers as the north of Tianshan mountains, mostly nature tours. We add the Urumqi and Turpan section in the tour, so that it includes cultural, historical and natural sites, which make your tour more meaningful and colorful.
Kashgar has many interesting places, you can see places very cultural, historical, as well as beautiful natural landscapes, deserts, grasslands, Local markets etc. Here we prepared for you 3 days Kashgar tour which including above featured places.
The Taklamakan Desert covers an area of 337,000 km2, makes it the second largest shifting sand desert in the world, Taklamakan means,"a world insight" in Uyghur language. The desert surrounded by Karakorum mountains in the South, Tianshan mountains in the North, Pamir mountains in the west, these mountains are also the place where the water comes to oasis land in Xinjiang.
Kashgar is the most historical city in the west China, the two routes of the Silk Road were joined in Kashgar, Caravans stopped here to exchange goods, buying and selling, this endows this city having the rich diversity of cultures and history behind it.
This itinerary includes most historical, Cultural and famous sites along the ancient Silk Road. Especially in Turpan, there is a lot to visit as we see how the Karez irrigation water system works, visit ancient ruins, and then experience the culture through a home-stay in an Uighur home.
If you have limited time around Urumqi and want to see the most valuable places around it, we suggest you take our 3 days tour around Urumqi and Turpan, you will enjoy the most important and historical sites.


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For Sale: Damir Doma
The only thing better than buying Damir Doma's perfect clothing is buying it for much, much less than originally advertised. The above shell fabric pants, taken from his FW11 collection, are voluminous, drop-crotchy and amazingly comfortable to wear—especially since I paid a mere 175€ for them. "WHOA, hold up there, you Hollywood asshole!", you might be thinking. "That's still a lot of money for a damn pair of pants." Which is true, but it's considerably cheaper than the original price tag. Besides, everyone should have a few really nice articles of clothing. Even sitting in your closet, it's such a good feeling. Off-season shopping is where it's at, and Berlin's YUU is a great place to start…if you live in Berlin, anyway.
Post-Soundtrack: Daniel Jones recommends Broadcast's <i>Berberian Sound Studio</i>
Losing Trish Keenan meant more than losing the haunting voice of Broadcast. It also meant losing a true artist who was always willing to step into new realms of audio exploration and invention. This made her an obvious choice to soundtrack Peter Strickland's art-thriller movie Berberian Sound Studio, a film about the nature of reality and how working with sound can blur our perceptions of what exists and what we create. It's a shame that we only hear it now, when she has gone.
The thirty-nine sound pieces on the OST run for less than 40 minutes altogether, and somewhere in the middle of it my workmate across the table started playing the new A$AP Rocky. 70% pitched-down "UHH"s plus Santigold. No thanks. What on earth happened to him? Even when he's rapping about something as boss as Damir Doma, it doesn't feel fun… more like a hype grab. Oh, it's off now.
The nature of Berberian Sound Studio means that the longer 'full-length' tracks, while giving Keenan and partner James Cargill more space to play in, aren't necessarily the strongest ones. Shorter pieces mean that more emotion needs to be conveyed quicker, more directly. "The Equestrian Vortex" ushers us in, urgently taking the listener down a spiral staircase of vintage piano riffs and autumnal doom that drifts into the harpsichords of "Beautiful Hair". With nods to horror scores from the '50s through to the '70s, many of the soundtrack elements will feel familiar, but never tired. It's that comfortably disturbing feeling you get when you're seeing a horror movie again, only this time you're home alone, the lights are out and just maybe you're not alone. Unease is a keyword, especially in the processed screams, Satanic chants, and wet splatters that begin to creep into the music as the film itself winds on. Longer pieces such as "Teresa, Lark Of Ascension" feel like vintage Broadcast tracks, which helps alleviate up the jumpy, ADD mood one gets when listening to soundtracks. The music here may not always be the most engaging music Broadcast have given us, but it's certainly some of the most compelling. Unless you're being distracted by an unfortunate Skrillex collab in the background why is that A$AP album on again ˜
Audioccult Vol. 31: Daggers & Dodecahedrons
Light a candle. Draw the required sigils. Now, raise your arms above your head and slowly, gently, exhale your soul. You won't need it here. This is Audioccult, and it's time to get low. Illustration: Simone Klimmeck
Everything feels like it's happening lately. Seeing Le1f finally blow up this year has been a delight. Vatican Shadow has filled a musical void I didn't even know was in me. The Rihanna Plane situation has provided laffs aplenty thanks to crazy fun + spoiled popstar, though I legit hope the plane lands at some point and they open the door and a slurry of bones pours out because I haven't seen X-Files in a while. And, of course, all that other stuff.
As I've been writing this column for something like half a year now, I've presented various genres of music and odd bits of writing to the ever-vague Reader, which I suppose is you. Hello, you. I hope you've been pleased or repulsed by this column. One of those, or something else. I hope for a response, on any level, because it's Cool to Feel. Even if it's just via standing close to the speaker during a hot bass rumble.
I've been editing music more than I've been listening to it these last few weeks. As this year has progressed, so too has my career as a DJ. Yes, anyone can do it, but not everyone can do it well. I suspect my secret has more to do with my tendon-stretched, hyper-alien dance moves and penchant for occasionally taking off my clothing than any great technical ability, but having a weird way of looking at things is another good tool. I'm more inspired by the idea of mashups than proper remixes: the idea of taking two things and making something new and unintended is very appealing to me. This is also why I have so many kids. Bad dad.
The next edition of Audioccult will be a live mix from my debut appearance in Budapest, where I'll be DJing for the launch party of the fashion-as-art magazine NERO Homme. This marks the first occasion I've performed at a fashion event. Although the aesthetics of KTZ, Damir Doma and the like are all very much my shit, I'm not really a fashion person. Give me a nice piece of clothing and in two days it'll have a pizza stain. The few fashion people who've shown up to my parties usually stand off to the side for a bit, then leave once the clothing starts coming off. I'm sure it will be fun, however, and I always aim to please. I have a very ritualistic set planned, pieces that are introspective and deep and personal to me. I'll probably just play R&B and trap, though. It's all about that fast money, baby!
We don't make these in your size: an open letter to shoe designers
See that photo up there? Those are the Provensen Pow Wow Ankle Boots. As with almost any good-looking, unique shoe in fashion, they do not come in men's sizes. This is an open letter to designers everywhere: not only women enjoy having cool shoes. Most of the time I feel trapped in my eight-hole Docs simply because it's so hard to find unique, strange, fashionable shoes in my size (10 1/2 US) and I'm not going to wear the same bland bullshit that most men are offered.
Solestruck's The Damned line is a rare example of designers recognizing this, though it pushes it to the opposite extreme by offering mainly heeled shoes. I don't want giant heeled shoes. I want the Damir Doma creepers in my size. I want to slip into Balenciaga's cutouts on a hot day. And I sure as hell want to cram my big dude hooves into Provensen's Pow Wows. Why is this so hard?
I don't live in a fantasy world where everyone has the same taste as me. I know that the market for interesting mens shoes is relatively small; most guys really are satisfied with 'just whatever'. But some seriously hate it. So why not extend your market a bit? Do limited runs. Offer exclusives. And contact me about it first.
When he's not writing and editing for Electronic Beats, Daniel Jones is a music promoter and creator of the subculture reconceptualization & aesthetics tumblr Gucci Goth.
Layers London: The Art of Fashion
When it comes to dream-shopping, few stores offer the wide range of fantasies that Layers London affords. Created by Keven McDermott and Cheng Qu, the concept store stocks not only bigger names like Rad Hourani and Gareth Pugh, but also up-and-coming designers. The selection is curated perfectly; while there's plenty of variance in styles, everything feels like it fits side by side. The prices are such that you won't be stocking your wardrobe here exclusively, but you can easily find a dozen needful things that will make you set aside your extra cash for. Here's a few of our top picks that will help make your AW wardrobe something truly special.
Normally people talk tops before anything, right? But sadly you generally can't show your bare butt+balls in public, so let's cover that first. Lately I find myself eschewing the skinny jean in favor of slightly more voluminous pants. These slouch-tucked trousers from Forme D'Expression are technically womenswear, but nix the suspenders and they totally work as unisex. Clean, lovely and extremely comfortable. The double layer long skirt from Damir Doma is equally stunning. Doma's blend of futuristic and traditional world influence creates something uniquely timeless.
I fell in love with this knitted top from Individual Sentiments the first time I touched it. Immensely comfortable, the slightly extended arms add a level of snug coverage that makes this one of my favorite pieces of cold-weather clothing. Ma_Julius' wire-neck blouson is equally cozy, and the shock of white adds a nice contrast to the normal darker tones of cold-weather clothing.
I'm a shoe whore. If I could, I'd wear a new pair every day. But since I'm just a writer, I have to make do with the occasional splurge. I've been lusting over the Damir Doma creepers for months now, and they still haven't made them in dude sizes. As a consolation prize, however, you can pick up some beautiful horse leather creeper boots that will immediately become the coolest thing you own. For the girls, you can still get the normal creepers (you jerks) or the pony skin versions here. For something so sleek and sexy your junk will tingle, these unisex heeled boots from Gareth Pugh are the perfect choice. But if I had to pick any one thing from Layers London to shove my weird feet into, it would be the high tops by Julius. With beautiful criss-crossing straps and a zipper on the back to accommodate the lazy (hello there) these are perfect for high-class casual everydaywear.
Ma+'s box hat is a beautiful way to keep your head warm and handsome, as is the Serien Umerica hat with its buckled strap running down the back. For a sable-chic alternative to purses or wallets, Gareth Pugh combines both as a necklace-bag that's almost too pretty to stretch out with nonsense like money and credit cards.
Neither you nor I are probably going to own even 1/3 of this lovely stuff anytime soon, but there's surely one or two things at Layers London that you'll fall in love with and say, 'I need this in my life.' Your bank account may not thank you, but your body will.


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Explore Kuching City Central is a project to promote the city central in Kuching. It can be an educational material and a tourism guide game for all. Most importantly, it can helps the youngster to learn and protect the place.
Borneo Art Collective is an online non-profit sharing platform for tangible and intangible Bornean culture


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Breaking: Video: Three Die in Bonny Sea Toady, Student of River State University and University of Port Harcourt
THREE persons, lost their lives today during a boat accident in Bonny Local Government Area of Rivers State.
A community source told our correspondent that the boat capsized after facing a strong wind in the middle of the sea in Bonny.
The boat was moving from Bonny to Port Harcourt when the unfortunate incident occurred.
FOX NAIJA learnt that though the number of those on board the ill-fated boat had not been ascertained.
It was learnt that a lady, whose name was not immediately given, died in the accident.
The source, who spoke with FOX NAIJA on the telephone, explained that the lady, who was announced dead, was a student of The Rivers State University, the other two was a Gentle man who is believed to be a student of University of Port Harcourt and a man believed to be the owner of the boat.
"It was a local boat and we learnt that three lives were lost. There was a very terrible wind and a heavy rain this morning.
Spokesman for the police in the state, confirmed the incident, but added that he had yet to get details of what happened, including the number of those who lost their lives.
"I can confirm to you that there was a boat mishap, but the detail is still sketchy. I will get back to you as soon as I am fully briefed on it," spokesman said.
Video Below:


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Medina, Tennessee
0 Reviews | Review This Place | Photos and Maps
Medina has an unemployment rate of 4.5%. The US average is 3.9%.
Medina has seen the job market increase by 1.6% over the last year. Future job growth over the next ten years is predicted to be 36.6%, which is higher than the US average of 33.5%.
Tax Rates for Medina - The Sales Tax Rate for Medina is 9.8%. The US average is 7.3%. - The Income Tax Rate for Medina is 0.0%. The US average is 4.6%. - Tax Rates can have a big impact when Comparing Cost of Living.
Income and Salaries for Medina - The average income of a Medina resident is $23,484 a year. The US average is $28,555 a year. - The Median household income of a Medina resident is $62,091 a year. The US average is $53,482 a year.
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Includes Cost of Living compares for child care, utilities, transportation, health, taxes, housing for home owners vs renters, weather, insurance premiums and so much more.
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A wide variety of stpg370 steel pipe options are available to you, such as a53(a,b), 10#, and q235. You can also choose from astm, bs, and aisi. As well as from structure pipe, boiler pipe, and oil pipe. And whether stpg370 steel pipe is iso, ce, or bsi. There are 2,891 stpg370 steel pipe suppliers, mainly located in …
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Thank you for visiting our stand!
We would like to thank you all for visiting our stand.
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In the field of fasteners we guarantee you prompt delivery of quality products at fair prices. Nearly all of our products correspond to international norms and standards. In our catalogue we present a wide range of fasteners and securing elements such as wing nuts and wing screws.


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It is a 5km run - it's you against the clock.
Every Saturday at 9:30am.
It's run on on the Beach Esplanade, Aberdeen. See Course page for more details.
Nothing - it's free! but please register before your first run. Only ever register with parkrun once. Don't forget to bring a printed copy of your barcode (request a reminder). If you forget it, you won't get a time.
We all run for our own enjoyment. Please come along and join in whatever your pace!
It is entirely organised by volunteers - email firstname.lastname@example.com to help.
Every week we grab a post parkrun coffee at The Brig O' Don, 739 King Street, Aberdeen, AB24 1XZ - please come and join us!
Alan BROWN • Catherine SHANKS • Christine BELL • David MACLENNAN • Fiona SEWELL • Jayne ADDIE • Kerri PALMER • Malcolm SHENNAN • Margaret TURNER • Mark FINDLAY • Mark MCDONALD • Mike MACKAY • Mitchell RENNIE • Paul BATE • Paul Kevin WEBSTER • Ronan CLANCY • Samantha PATERSON • Vivien BROUGHTON
Aberdeen parkrun takes place every Saturday at 9:30am


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It took a while, but USAA tracked down the woman who hit my motorcycle. I'm very tempted to post the person's name who hit my bike and took off like a coward. However, I'll take the high road here. So here's the story, the woman has no insurance and can't pay for the bike. They're going to set her up on some sort of monthly payment plan thing. Not my issue though, I sent USAA my repair paperwork and they're going to pay me right away. The best part is, I don't even have USAA as my insurer any longer. I had to switch to Geico when I sold the S4 (USAA won't write motorcycle-only policies if you've been riding less than 3 years). So it's not like they can raise my rates if they wanted to!
I'm pretty stoked now, but I'll be buying a round once I get check in hand.


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0 Reviews
Golf Courses in Bradford
Headley La, Bradford, West Yorkshire, BD13 3LX
01274 833481
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A native New Englander, Jimmy is a product of the Newton, MA public schools. In 1979 he graduated from Tufts University where he started his 40 year career as sports producer at WBZ TV4 at the age 20. Hired by the CBS affiliate in Portland Maine in 1981 as a sports anchor/reporter, Jimmy worked at WGME TV13 for 11 years hosting shows, reporting from major sports events, and doing play by play for area colleges and high schools. In 1992, he returned to his hometown of Newton, MA where he joined the original team of New England Cable News. He hosted "Jimmy Young's Sports World" at NECN from 1992-98. He also won a regional Emmy Award for the nation's first TV sports talk show for kids, Kid Company's Sportworld with Drew Bledsoe as special guest. He currently lives in Needham, MA.
Currently the Co-host on Friday Afternoon Live with Dan Lothian and Jimmy Young streamed on Facebook at Little Park Media. LPM is owned by Dan Lothian a veteran of 35 years at the network news level for NBC, and CNN as White House correspondent.
Jimmy and Dan work together on video production projects, podcasts, and educational opportunities. Jimmy currently teaches an Introduction to Sports Broadcasting on Radio & TV at Curry College, and a graduate course at Dean College focusing on the impact of Mass Media in the digital age. Jimmy is as comfortable on camera, or behind a microphone, as he is in real life.
Since the age of 7, Jimmy loves all sports, especially the one "in season. He excelled at soccer where is has been a fan, player, and coach. Called "jogo bonito", or soccer, he always gave equal respect to the game during his sports career. During the 1994 World Cup in the USA, he interviewed some of the greatest soccer names in history, Pele, Maradona, Karl-Heinz Rummenigge, John Harkes, Taylor Twellman et al; Coaches Jack Charlton, Bora Milutinovich, Bruce Arena. the '94 World Cup Highlights show earned Young and his team at NECN, an Emmy nomination for a sports special. In 1996-7, he was the TV color analyst for the NE Revolution MLS team.
As a licensed USSF Youth Coach, he has coached at every level from high school varsity, to state, club, and his son's travel team for 12 years. He is a dedicated father, coach, teacher and mentor to hundreds of young people he has inspired over the past 40 years


text:
Charlotte from Ashburn Age: 22. I will gladly invite you to visit! Tender and passionate!
Lucy from Ashburn Age: 22. Who can keep me company today?
Power Rangers Giantess Brazzers Logo
Regina from Ashburn Age: 21. I will become the mistress of a young charismatic man.
Anita from Ashburn Age: 27. I invite you to visit a very intimate meeting! I know how to give men what they lack in bed...
Video On Demand Go Anywhere. The new parody is from Brazzers, and fans have their first glimpse at the production thanks to Twitter, where photos of the cast and the official cover have surfaced. Free Preview of Power Pussy Rangers. This message will disappear in. Rawhide movie from Digital Playground 18 min 1. Whore Of Wall Street, The. While that might not be your cup of tea, the recent Power Rangers reboot is also coming to video soon, and you can get all the details on Blu-ray and DVD versions below. Premium PPM allows us to bring you the best Adult content from the hottest studios. You may verify this by looking at the source url of the videos and images. Yep, you read that right, and this is the second one that has been released for the Rangers.
Suzanne from Ashburn Age: 35. A young and pretty girl will meet a man. Ideally, I would like to find a lover.


text:
Primary Endpoint was met, with rhC1INH treatment reducing neutrophil
gelatinase-associated lipocalin (NGAL), a widely recognized marker of acute
renal damage
Pharming Group N.V. ("Pharming" or "the Company") (Euronext Amsterdam:
PHARM) today
announced positive results from a Phase II investigator-initiated study of
(recombinant human C1 esterase inhibitor, or "rhC1INH") in a double-blind,
placebo-controlled clinical trial in patients at risk of nephropathy resulting
contrast-enhanced examinations.
The study was led by Dr. Michael Osthoff at the University Hospital Basel,
Switzerland. 75 eligible patients with known moderate to severe renal function
were given either 50 units per kg (up to 4200 units) of RUCONEST(R) (n=37) or
(n=38) immediately prior to treatment with standard-of care contrast medium as
part of an
elective coronary angiography with or without a percutaneous coronary
intervention ("PCI"),
and then a second identical treatment four hours after the intervention .
In the overall study, RUCONEST(R) showed a statistically-significant effect
(p= 0.038)
in reducing the rise in urinary Neutrophil Gelatinase-Associated Lipocalin
(NGAL), the
primary endpoint for the study and a generally recognized early marker of acute
injury, in patients with diagnosed renal function impairment undergoing
enhanced with standard contrast media such as PCIs.
The results were especially clear in the sub-group of patients (n=30)
undergoing PCI.
The intent-to-treat analysis in this group showed that patients on RUCONEST(R)
had a
median increase in peak urinary NGAL concentration within 48 hours of 1.8 ng/ml
with an increase of 26.2 ng/ml in the placebo arm (p=0.04). This corresponds to
a clear
difference in the median percentage change in the peak urinary NGAL level within
48 hours
of 11.3% in the RUCONEST(R) arm and 205.2% in the placebo arm (p=0.001).
The overall assessment of the study also showed trends that patients
undergoing more
invasive interventions and procedures requiring higher volumes of contrast
experienced a stronger benefit from the RUCONEST(R) treatment.
The treatment also showed an excellent safety profile comparable to the
placebo group
- a particularly significant observation considering the high-risk patient group
in the study (average age approximately 77 years, with multiple comorbidities
and impaired
kidney function)
This data therefore supports additional clinical investigations for the use
of rhC1INH
in a new indication where there is significant unmet medical need.
A secondary endpoint measured was Troponin T, a marker of cardiovascular
damage caused
by the examination or intervention itself, but this did not show a meaningful
in the overall study population: the power of the study and the variety of
applied were not suitable to perform an appropriate evaluation.
Following these positive results, Pharming will continue discussions with
Dr. Osthoff
and other experts in this area with the aim to perform further clinical
development to
establish the efficacy and efficiency of RUCONEST(R) treatment in the patient
group likely
to experience the greatest benefit. Dr. Osthoff will be publishing the full
results of
his study in due course.
Dr Michael Osthoff, Basel University Hospital Basel, Basel, Switzerland and
Investigator, said:
"We are very pleased that we were able to provide an early proof-of-concept
dosing RUCONEST(R) ahead and following contrast enhanced investigations and
particularly in those patients that have to undergo PCI, may limit subsequent
damage to
these patients' kidneys. We believe that these positive results merit further
investigations and confirmation in a larger trial, and we are very keen to
continue the
collaboration with Pharming."
Dr Bruno Giannetti, Chief Operations Officer of Pharming, said:
"Reaching a significant difference already in a small number of patients in
well-run exploratory trial gives a surprisingly clear positive signal in what
could become
a large new indication for RUCONEST(R).
"Furthermore, invasive interventions requiring contrast medium applications,
like PCI,
are known to cause damage to organs like the kidney and the brain through small
thromboembolic events triggering complement cascade activation. RUCONEST(R) is a
recombinant form of the most important element of the body's own complement
braking system. NGAL is a sensitive indicator to detect and assess this
combined damage
in this particular situation. These results therefore also provide important
information on the potential protective effects of RUCONEST(R) in a number of
indications like pre-eclampsia or reperfusion injuries, in which complement
activation is
thought to play an important role."
As planned, Pharming has filed for regulatory approval in the Netherlands
and shortly
also in Australia to begin the first clinical study of RUCONEST(R) in
About Contrast-induced Acute Kidney Injury ("CI-AKI")
Acute kidney injury (AKI) affects 13-18% of all patients admitted to
hospital in
developed countries. The estimated general incidence of CI-AKI is
approximately 7%. Its
incidence may increase to >50% in the presence of risk factors such as
chronic kidney
disease, diabetes mellitus and nephrotoxic drugs[1].
These estimates apply to over 38 million contrast-enhanced investigations in
the USA
alone, and around the same number in the rest of the world. In practice, the
majority of the patients affected are those with existing kidney impairment,
which is
estimated variously at between 13%-21% of the total. This implies a potential
addressable market size of several million patients in each of those main
About Contrast-induced Nephropathy
Contrast-induced nephropathy (CIN) is a very serious form of AKI, a
complication of
angiographic procedures resulting from the administration of contrast media. It
is the
third most common cause of hospital-acquired acute renal injury and represents
about 12%
of the cases. CIN is defined as an elevation of serum creatinine of at least 25%
greater than or equal to0.5 mg/dl (44 mumol/l) from baseline within 48 h. The
incidence of
CIN varies between 0 and 24% depending on a patient's risk factors. It is
generally a
transient and reversible form of acute renal failure. However, the development
of CIN is
associated with longer hospital stays and an increased morbidity and mortality,
addition to a higher financial cost. A meta-analysis that included 40 studies
found a 6%
incidence of CIN after contrast-enhanced computed tomography (CT) scans, 9%
peripheral angiography and 4% after intravenous pyelography. The incidence of
CIN is low
in patients with normal renal function (0-5%). However, several prospective
trials reported an incidence of 12-27% in patients with pre-existing renal
Furthermore, in one study, an incidence as high as 50% was reported in patients
diabetic nephropathy undergoing coronary angiography in spite of the use of
contrast media and adequate hydration. Notably, up to 15% of those patients
The best care available today still results in very serious consequences for
patients (with 6%-11% proceeding to dialysis or worse outcomes depending on the
used and their level of renal performance prior to the scan, according to
various studies),
although this is improving slowly as new less-damaging contrast media are
About NGAL
NGAL (neutrophil gelatinase-associated lipocalin, also known as lipocalin-2
and as
siderocalin) is a protein involved in innate immunity
[https://en.wikipedia.org/wiki/Innate_immunity ] responses. It is expressed in
neutrophils [https://en.wikipedia.org/wiki/Neutrophils ] and in low levels in
the kidney
[https://en.wikipedia.org/wiki/Kidney ], prostate
[https://en.wikipedia.org/wiki/Prostate ]
, and epithelia of the respiratory [https://en.wikipedia.org/wiki/Respiratory ]
alimentary tracts [https://en.wikipedia.org/wiki/Alimentary_tract ], including
the renal
tubules. Renal expression of NGAL is dramatically increased in kidney injury
from a
variety of causes, and NGAL is released primarily into both urine but also
plasma. NGAL
levels rise very quickly after the event triggering kidney difficulty, making
NGAL an
early and sensitive biomarker of kidney injury. Both plasma and urine NGAL
correlated highly with serum creatinine concentrations. Kidney biopsies in these
showed intense accumulation of immuno-reactive NGAL in 50 % of the cortical
tubules. These
results identified NGAL as a widespread and sensitive response to established
AKI in
humans[3]. Specifically, the predictive utility of NGAL for AKI in CIN has been
in a recent meta-analysis[4].
About Pharming Group N.V.
Pharming is a specialty pharmaceutical company developing innovative
products for the
safe, effective treatment of rare diseases and unmet medical needs. Pharming's
product, RUCONEST(R) (conestat alfa) is a recombinant human C1 esterase
inhibitor approved
for the treatment of acute Hereditary Angioedema ("HAE") attacks in patients in
the US, Israel and South Korea. The product is available on a named-patient
basis in other
territories where it has not yet obtained marketing authorization.
1. Source: Contrast Medium-Induced Acute Kidney Injury
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478328 ]: Umar Sadat, Ammara
Jonathan R. Boyle, Paul D. Hayes, Richard J. Solomon. Cardiorenal Med. 2015 Jun;
2. Source: Contrast-induced Nephropathy
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969626 ]: Nazar M. A. Mohammed,
Mahfouz, Katafan Achkar, Ihsan M. Rafie, Rachel Hajar. Heart Views. 2013
Jul-Sep; 14(3):
3. Neutrophil gelatinase-associated lipocalin (NGAL): A new marker of kidney
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528839 ]: Prasad Devarajan, Scand
J Clin
Lab Invest Suppl. 2008; 241: 89-94.
4. Neutrophil Gelatinase-Associated Lipocalin in the prediction of
Nephropathy, a systemic review and meta-analysis: Tong j, Li H, Zhang H et al, J
Cardiovasc Pharmacol 2015; 66: 239-45.
RUCONEST(R) is distributed by Pharming in Austria, France, Germany,
Luxembourg, the
Netherlands, the United Kingdom and the United States of America. Pharming holds
commercialisation rights in Algeria, Andorra, Bahrain, Belgium, Ireland, Jordan,
Lebanon, Morocco, Oman, Portugal, Qatar, Syria, Spain, Switzerland, Tunisia,
United Arab
Emirates and Yemen. In some of these countries distribution is made in
association with
the HAEi Global Access Program (GAP).
RUCONEST(R) is distributed by Swedish Orphan Biovitrum AB (publ) (SS: SOBI)
in the
other EU countries, and in Azerbaijan, Belarus, Georgia, Iceland, Kazakhstan,
Liechtenstein, Norway, Russia, Serbia and Ukraine.
RUCONEST(R) is distributed in Argentina, Colombia, Costa Rica, the Dominican
Panama, and Venezuela by Cytobioteck, in South Korea by HyupJin Corporation and
in Israel
by Kamada.
RUCONEST(R) is also being examined for approval for the treatment of HAE in
children (2-13 years of age) and evaluated for various additional follow-on
Pharming's technology platform includes a unique, GMP-compliant, validated
process for
the production of pure recombinant human proteins that has proven capable of
industrial quantities of high quality recombinant human proteins in a more
economical and
less immunogenetic way compared with current cell-line based methods. Leads for
replacement therapy ("ERT") for Pompe and Fabry's diseases are being optimized
at present,
with additional programs not involving ERT also being explored at an early stage
Pharming has a long-term partnership with the China State Institute of
Industry ("CSIPI"), a Sinopharm company, for joint global development of new
starting with recombinant human Factor VIII for the treatment of Haemophilia A.
Pre-clinical development and manufacturing will take place to global standards
at CSIPI
and are funded by CSIPI. Clinical development will be shared between the
partners with
each partner taking the costs for their territories under the partnership.
Additional information is available on the Pharming website:
Forward-looking Statements
This press release of Pharming Group N.V. and its subsidiaries ("Pharming",
"Company" or the "Group") may contain forward-looking statements including
limitation those regarding Pharming's financial projections, market
developments, partnerships, plans, strategies and capital expenditures.
The Company cautions that such forward-looking statements may involve
certain risks
and uncertainties, and actual results may differ. Risks and uncertainties
include without
limitation the effect of competitive, political and economic factors, legal
claims, the
Company's ability to protect intellectual property, fluctuations in exchange and
rates, changes in taxation laws or rates, changes in legislation or accountancy
and the Company's ability to identify, develop and successfully commercialise
new products,
markets or technologies.
As a result, the Company's actual performance, position and financial
results and
statements may differ materially from the plans, goals and expectations set
forth in such
forward-looking statements. The Company assumes no obligation to update any
forward-looking statements or information, which should be taken as of their
dates of issue, unless required by laws or regulations.
For further public information, contact
Sijmen de Vries, CEO: T: +31-71-524-7400
Dr Bruno Giannetti: T: +31-71-524-7170
FTI Consulting
Julia Phillips/ Victoria Foster Mitchell, T: +44-203-727-1136
LifeSpring Life Sciences Communication, Amsterdam, The Netherlands
Leon Melens, Tel: +31-6-53-81-64-27
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text:
Mission Mangal | 'They know it all': Akshay Kumar celebrates power of women scientists
Mumbai | Jagran Entertainment Desk: Akshay Kumar, who will be featuring as Rakesh Dhawan in his next movie Mission Mangal, on Wednesday said that the movie is the story of India's women scientist.
He posted a picture of himself with the actresses of his movie on the instagram account and captioned it: "Be it making a home or launching a successful space mission, women know it all! Celebrating the power of women scientists: Mission Mangal is their story!"
View this post on Instagram
Be it making a home or launching a successful space mission, women know it all! Celebrating the power of women scientists : #MissionMangal is their story! @taapsee @aslisona @balanvidya @sharmanjoshi @nithyamenen @iamkirtikulhari @foxstarhindi @zeemusiccompany #CapeOfGoodFilms #HopeProductions #JaganShakti
Mission Mangal tells the story of scientists at the Indian Space Research Organisation who contributed to the Mars Orbiter Mission, which marked India's first interplanetary expedition.
The film stars an ensemble cast of Akshay Kumar, Vidya Balan, Taapsee Pannu, Nithya Menen, Kirti Kulhari, Sharman Joshi, H. G. Dattatreya, and Sonakshi Sinha.
The teaser of the movie was also released on Tuesday. Akshay on Instagram released the teaser and captioned it: "Ek Desh. Ek Sapna. Ek Ithihaas. The true story of India's Space Mission to Mars is here."
Akshay had earlier, revealed that he did Mission Mangal for his children.
"Specially for my daughter and children her age to familiarise them with the incredible true story of India's mission to Mars," he said in a tweet.
#MissionMangal , a film which I hope will inspire as much as entertain. A film which I've done specially for my daughter and children her age to familiarise them with the incredible true story of India's mission to Mars! @FoxStarHindi #HopePictures #JaganShakti @isro pic.twitter.com/yMwkCPr2KR— Akshay Kumar (@akshaykumar) July 4, 2019
The movie is scheduled for release on 15 August 2019. The first look poster of Mission Mangal was released by Kumar on 4 July 2019.
Posted By: Aalok Sensharma


text:
Power, Prestige, and a show-stopping Style.
The track-ready monster that you can actually win.
Time to fly!
German widebody power and style.
And this is just the start.
Blazing through the quarter-mile in 9.66 seconds at 145 mph.
Gettin' wide and low.
The ultimate road car from Woking.
Working some German magic.
What's EcoBoost again?


text:
I recently made a new batch of kyphi style incense from ingredients that I gathered all year long in my bioregion. Kyphi is a type of incense, originating in ancient Egypt, that is made with honey, mead, or some other sweet liquid that is usually alcohol based. There are many Kyphi recipes and, the incense I make is simply derived from this general style that I adapted to my local plants and the consistency I prefer. I have posted my Kyphi recipe in the past, but on recently referring to it for my current batch, I realized that I have changed some things. I also didn't think it was "user friendly" enough. When I cook or concoct, I have a habit of not really measuring; a quality that drives my students crazy and I have been sincerely trying to change how I convey my recipes so that anyone can use them. This is one such attempt, however, I truly believe that, once you get the hang of any recipe, there is room for artful intuitiveness and I encourage everyone to find a comfortable balance between proper proportions and how they personally would like the incense to end up.
Sacred Tea Ceremony
Many of us think of the Japanese tradition when we hear "Tea Ceremony" and they definitely have one of the worlds most beautiful and sacred ways of making tea a healing practice. Tea ceremonies have been done in different ways in many other cultures also. The English are famous for their afternoon teatime and a tea culture exists in many other countries where tea making is sometimes ritualized and sometimes just a part of daily life as is our American coffee culture. Many 'hip' communities in the United States now have "tea rooms" where people can gather and drink tea together while relaxing and visiting. There is even an "American Tea Ceremony" now that has been adapted from the Japanese version.


text:
We invite you to our 4th annual Dirty Water Tournament being held on Saturday and Sunday, July 6-7, 2019 in Boston. This is a small and intimate tournament for 6-8 coed teams in total. The idea is to get to know our fellow field hockey community, but maintain a competitive edge on the field. Please share and forward along to field hockey friends!
PLAYER ELIGIBILITY: Must be non-NCAA eligible to avoid any violations with current coaching staff.LOCATION: Boston, MA area (field: Boston University - New Balance)COED: Up to (5) five men on the field. Goalies are gender neutral and do not count in that tally.ROSTER: Up to 20 players, cannot interchange between other registered teams (even same club)SOCIAL SATURDAY NIGHT: T's Pub, 933 Commonwealth Ave, Boston, MA
RULES:- (4) 30 minute running Pool games per Team; 4 minute half-time, 5-min warm up / between games- 30-minute running Playoffs- Team listed first is considered the Home team and gets choice of uniform (whether dark or white)- 5 Points for a win; 1 Point for a Tie- Priority of ranking: Points, Head-to-head, Goal differential, Shootout tie-breaker- Tie-breaker: Best of 5 shootouts; if a second round is required, golden goal granted with same 5 players (any order)- All players must be qualified roster players (Non-NCAA). Max. 5 men playing at the same time. Goalies are gender neutral. All must sign 2018 NEPL liability waiver. NOTE: Game times may be changed due to OT conditions or weather conditions.


text:
For the other issues included in the survey, it is less clear whether President Trump or the Democratic candidate has an advantage. The Democratic candidate has a seven percentage point edge on foreign policy while President Trump has a seven point edge on gun policy1; however these slight advantages are not statistically significant. Similar shares of swing voters say they prefer President Trump or the Democratic nominee on international trade and tariffs and taxes.
When swing voters who say health care is an issue that would make them more likely to vote for Democratic candidate (50% of swing voters) are asked to say in their own words what it is about health care that could influence their vote choice, nearly half (44%) offer responses related to increasing access to health insurance coverage. This is followed by one-fifth (19%) who offer lowering the amount people pay for health care. Fewer offer responses such as: Democrats care more about health care (7%), general opposition to President Trump (7%), or support or protection of the Affordable Care Act (7%).
On the other side of the ballot, when swing voters are asked to say in their own words what it is about health care that would make them more likely to vote for President Trump (32% of swing voters), they offer a variety of health care issues that could influence their vote choice. About one in six of these swing voters say lowering the amount people pay for health care (16%), free market or less government involvement (14%), opposition to the ACA (13%), or opposition to a national health plan or Medicare-for-all plan (12%) make them more likely to vote for President Trump in 2020.
Lowering the amount people pay for health care is the only health care issue that was offered by substantial shares of both swing voters who say the issue of health care makes them more likely to support President Trump (16%) and those who say it makes them more likely to vote for the Democratic nominee (19%).
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