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Hopes that discord between resident doctors and district health boards might be settled quickly took a blow yesterday after the union announced a second strike.
The doctors — who are scheduled to walk off the job for 48 hours from 7am on Tuesday — also plan to strike on January 29 and 30.
Mediation talks between the parties failed earlier this week, and doctors' union the New Zealand Resident Doctors Association (NZRDA) yesterday termed the dispute as "bitter".
"This vote for a second strike testifies to their resolve," union organiser David Munro said.
"The resident medical officers are clearly not going to be backing down."
Thousands of patients nationwide, including hundreds in the southern region, are being contacted by district health board
staff to advise them operations and appointments scheduled for next week are being postponed.
The strike will affect Wakari and Dunedin Hospitals, Southland Hospital, Lakes District Hospital and all community-based health services where NZRDA junior doctors employed by the SDHB work.
SDHB chief executive Chris Fleming said he was disappointed NZRDA members had voted to strike.
"It will have an impact on the services we deliver which will extend beyond the two days of the strike," he said.
"At this time, we're still finalising our rosters and so cannot yet say how many NZRDA doctors will be striking next week."
Senior medical officers and some resident medical officers would work during the strike.
"We are still determining how many planned surgeries will have to be postponed," Mr Fleming said.
"The situation is fluid and is changing as we get further clarity about who will be working on the day of the strikes."
All hospitals will remain open during the strike and essential and urgent services — including emergency departments, acute surgery, intensive care, cancer treatments, maternity services and renal dialysis — will be provided.


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The recently released Bengali movie 'Autograph' starring Prosenjit Chatterjee will be screened at the 10th Annual Mahindra Indo-American Arts Council (MIAAC) Film Festival. The movie will be screened on 11th November at SVA Silas Theatre at 6 pm.
The film is directed by Srijit Mukherjee, who is quite experienced in the field of Bengali and English stage theaters. According to the director, he has attempted to pay a tribute to the legendary filmmaker Satyajit Ray's movie Nayak starring Uttam Kumar and Sharmila Tagore.
The movie has been produced by Mahendra Soni and Shrikant Mohta of Shree Venkatesh Films. Apart from Prosenjit, the movie also stars Nandana Sen and Indraneil Sengupta. The story revolves around three people, one of whom is a young aspirant director and wants to make a film called Nayak. The other two characters are that of a theater actress and a superstar. The film depicts how their life changes when they come together during the making of the movie.
The film also stars Rudra Prasad Sengupta and Piyush Ganguly in important roles. Bodhaditya Banerjee has done the editing of the film. Debojyoti Mishra and Anupam Roy have composed music for Autogrpah, which has lyrics by Srijato, Anupam Roy and Srijit Mukherjee. The director has also written the story, screenplay and dialogues of the movie.


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Dea and Kevin | Seattle Municipal Courthouse Wedding
Dea and Kevin had a crazy windy day for their Seattle Courthouse wedding. It was much different than I was expecting. I was expecting to be running from the wind and rain all day, but we spent most of it outdoors in the gusts!


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Expert Determination
John Kendall, Clive Freedman and James Farrell
Product details
Format: Book
Pages: 440
Publisher: Sweet & Maxwell
Date Published: Apr 2008
Stock Code: 68555
Binding: Hardback
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This comprehensive and practical guide covers entire process of expert determination. Expert Determination:
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Mattel & Warner Bros. Announce Live-Action Hot Wheels Movie
Taking the die-cast toy cars to the big screen.
Following the creation of Mattel Films, and a recently announced "Barbie" feature film starring Margot Robbie, toy company Mattel has once again partnered with Warner Bros. to announce a Hot Wheels live-action movie adaptation.
The hot-selling die-cast cars are currently ranked as the number one selling toy in the world, with more than 500 million units being sold each year. Considering the company's history with youth and adults alike, it's only fitting that the company has once again partnered with Warner Bros. to bring its prized toys to the bring screen. In a report published by Variety, Mattel CEO Ynon Kreiz shared his enthusiasm for the project:
"Mattel Films has great momentum as it continues to execute on our commitment to bring global audiences new ways to experience the brands they love as we transform Mattel into an IP-driven, high-performing toy company."
Warner Bros.' chairman Toby Emmerich also commented:
"Hot Wheels has been inspiring the imagination of kids around the world for over 50 years. We couldn't be more excited to be bringing the adrenaline, adventure, and excitement of Hot Wheels to the big screen."
Are you excited to see your favorite toys coming to theatres? Let us know what cars you'd like to see featured in the movie below, and keep your eyes peeled as more information surrounding the newly-revealed project will likely be dropping in the near future.
For more entertainment news, Ben Affleck is hanging up his role as Batman.
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- Variety
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Fundamental Analysis for Forex Trading, A Free Video for Newbie in urdu/hindi
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The Best Currency Pair to Trade in Forex Market
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Power-One Debuts QNT Quarter-Brick DC Converter
Power-One Inc. (Camarillo, CA) introduced its new QNT36ZEDB 80 W, quarter-brick, dc-dc converter, which converts a 36 Vdc to 75 Vdc input into three 12 A outputs that adjust from 0.95 V to 5 V. The combination of flexibility, performance and full-isolation facilitates the use of one part for a variety of applications. In selected applications, the converter can also provide a single-component alternative to distributed power architectures.
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Timothy - This month's biblical character
Published on Tuesday, 14 May 2019 11:45
Timothy was a native of Lystra in Phrygia (which is now part of the Asian half of modern day Turkey). His father was Greek, his mother Eunice (and grandmother Lois) were Jewish. Being of a mixed race parentage was no easier than it is today so no doubt he had to deal with lots of difficult situations as he grew up.
He was converted to the Christian faith through the influence of Paul. He then spent many years accompanying Paul and Silas on missionary work. He was a messenger from Paul to the churches of Corinth and Thessalonica. Trusted to be accurate in conveying Paul's letters and words to those churches.
He was involved in Paul's journey to Troas and he was left as leader of the church in Ephesus for a time. Being only about thirty-five years old this was considered a quite young age to be leading a church congregation. Paul writes two letters to him while he is in this responsible position (1 & 2 Timothy). The letters are words of thankfulness to God for his faith and loving, caring lifestyle. They also provide
encouragement to him as he develops in a difficult role. Timothy was prone to illness and rather shy so this letter encourages him to utilise God's strength to fulfil these leadership roles.
He is an example to us as, whatever our background or circumstances (no doubt he was just as busy in his thirties as we are in our modern age), he put God first and took on responsible roles in the church so that the congregation developed and God's message was shared with all.


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Built-In Wardrobe
The following post contains affiliate links. To learn more about what this means, please visit our disclosures page here.
Finally! We have a place to put our clothes!! This was such a fun project, but BOY was there a learning curve! Our goal was to extend the bedroom floor a bit, to give us some moving space at the end of the bed, and have our wardrobe be the space beneath that area. Next to the wardrobe will be our stairs. But our ladder will do for now, so stay tuned for a post on that later!
Just like our bathroom vanity, the only materials we used to construct the wardrobe were 2x2s and our leftover pine. We started by making a frame to support the floor above it, as well as the drawers between:
We refined our design (mostly of the stairs) to look like this:
I was determined to cut all of the pieces out for the 10 drawers and just begin assembling them all, but Brian (my voice of reason) asked me - "why don't you assemble one and figure out what you like and don't like about it before making the rest?"
I, then grumbling, turned out to be grateful he suggested that, because I immediately realized I didn't leave room for the drawer slides in my first drawer design! I did not include a photo of the first screwed up drawer, but we found use for it as a crate. :)
This is our actual first drawer:
I routed channels on the inside face of the front panel to slide the sides into. We had rabbited joinery at the back of the drawer, and along each side, at the bottom, I routed a channel for a 1/4" plywood bottom. I then wood glued and pinned it all together.
Then I went to town on the rest!
I installed some clothes hanging rods that pull straight out, so we could hang some shirts: his on the right, mine on the left.
The trickiest part was actually the hanging of the drawers. The glides were tricky to line up, even if you checked and rechecked your measurements over and over!
And of course the more drawers I hung, the trickier it was to make sure everything lined up and nothing rubbed against each other, thus making the drawers impossible to close.
I decided to make use of the 4"x9" empty spaces above the shoulders of our hangers. I made four "secret" drawers that you have to open the wardrobe doors to get to. Here's the first one installed while the others wait patiently:
To avoid protruding hardware on these secret drawers, I simply used my handy router to cut out finger slots from the front face of the drawer so you can grab with a couple of fingers to open it.
Phew! Getting the drawers done was a chore. Notice we don't have the luxury of a toe-kick at the floor? Every inch counts, so we couldn't afford to waste the space!
It was time to dry fit the doors. These were also made of just leftover pine from the walls and ceiling.
VIOLA! It took us several months of winter-building, only on weekends, and getting through the holiday, but we finally have a space in our home for our clothes:


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5 opposition bets vs lowering of age of criminal liability
MANILA, Philippines (UPDATED) – Five senatorial candidates from the opposition are against proposed legislation that would lower the minimum age of criminal responsibility.
The House committee wants to lower the minimum age to 9, from 15 years old, while at the Senate two pending bills are proposing 12 as minimum age..
Re-electionist Senator Benigno Aquino IV said on Monday, January 21, that the bill is "immoral," after the House justice committee passed the bill that same morning.
Aquino said he "doubts" the bill would pass the Senate when the upper house adjourns in February. Senate's own committee was set to conduct a hearing on its version of bill on Tuesday, January 22.
"It's crazy, it's cruel, to be honest I think it's immoral. I doubt that this will pass the Senate in any way. If this passes the House, let that be up to their conscience, pero sa Senado po (but in the Senate), I'm certain this will not pass up to the time that we will have our break this February," Aquino said on Monday at an event of Aksyon Demokratiko, where the party endorsed all 8 candidates of Oposisyon Koalisyon.
Asked what legal argument could be invoked to block the bill, former solicitor general Florin Hilbay said not "to look at the proposal from the lens of the law," instead "from the lens of practical reasoning and morality."
"It just doesn't make any sense, so I think that's why they're called children, they can't even enter into contracts and yet you want to send them to jail?" Hilbay said.
Former Quezon 4th District Representative Erin Tañada added: "Sana nag-iisip din 'yung mga gumagawa ng batas. Kung 'yan po ay anak niya 'yan, handa ba silang ilagay sa kulungan mga anak nilang gumawa ng krimen? Sa tingin ko hindi." (I wish the lawmakers gave it some thought. If this applied to their children, would they be willing to put their children in jail if they committed a crime? I don't think so.)
Other opposition candidates such, as Magdalo Representative Gary Alejano and human rights lawyer Chel Diokno, earlier voiced their opinion against the bill at the CNN Philippines senatorial forum last December 2.
Calls to further lower the age of criminal responsibility were first revived after President Rodrigo Duterte himself proposed it.
The bets were given the option to raise a "yes" card or a "no" card to indicate their position.
The 3 bets who answered no were:
- Chel Diokno
- Bam Aquino
- Gary Alejano
The 5 bets who declared support for the bill were:
- JV Ejercito
- Juan Ponce Enrile
- Sergio Osmeña III
- Ronald dela Rosa
- Francis Tolentino
Republic Act 9344 or the Juvenile Justice Law of 2006 sets the minimum age of criminal liability at 15 years old – meaning those between 15 to 18 years old may be detained in youth centers and be put in rehabilitation programs. Those under 15 years old are exempted from criminal liability and undergo intervention. (READ: Beyond juvenile delinquency: Why children break the law)
Prior to this law, children were locked up in jails together with adults even for petty offenses. They were vulnerable to abuse during arrest and detention. An average of 10,515 children were arrested every year, the Department of Social Welfare and Development reported in 2014. (READ: On 2nd chances: Children in conflict with the law)
In 2012, RA 10630 was passed to amend the 2006 law. The new legislation allows children as young as 12 years old to be held criminally liable for serious crimes such as rape and murder, among others.
The law also mandates that local government units establish "houses of hope" or Bahay Pag-asa to offer rehabilitation, diversion, and intervention. – Rappler.com


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A seven-year-old girl, who was visiting a zoo in Morocco, has died after being hit on the head by a rock which was thrown by an elephant.
The tragic incident happened on Tuesday when the young girl was at a zoo, in the country's capital, Rabat, with her parents.
According to the Huffington Post, the girl was having a picture took with her family when the animal picked up a large stone and hurled it into the air before it dropped down onto the seven-year-old.
She was knocked unconscious immediately and taken to hospital where she later died from her injuries.
The zoo issued a statement on the incident claiming that their establishment was in line with international regulations.
They added:
This kind of incident is rare, unpredictable, and unusual. Accidents of this nature happened in international zoos, most recently in Disney World Orlando and the Cincinnati Zoo in the United States.
A video has since surfaced online showing the immediate aftermath of the horrific freak accident in which you can see the elephant in the enclosure as dozens of people surround the young girl who is unconscious on the ground.
The video also shows what appears to be the rock which was thrown at the girl.
Joseph Loftus is a Gold Standard NCTJ journalist with four years experience working for international and regional press.
As well as working for UNILAD and LADbible, Joseph has worked as Liverpool Correspondent for Unsigned & Independent Magazine, as well as stints with the Liverpool Echo and Warrington Guardian.


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For Your Marriage
A program designed to help couples understand God's plan for marriages.
Provides multiple resources and knowledge on the following topics:
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Visit www.foryourmarriage.org for more information
Marriage Encounter Weekends
A program for married couples to explore the sacramental dimension of their marriages.
English – Call Nick and Jen Rivette at 760-659-9102, or go to http://www.wwme-sandiego.org/
Spanish (Encuentro Matrimonial Mundial San Diego) – call Onofre and Maria Guerrero at 760-802-6441/760-807-8250 or go to encuentrosandiego.org
A program to help couples heal and renew their marriages.
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A multi-species comparative structural bioinformatics analysis of inherited mutations in a -D-Mannosidase reveals strong genotype-phenotype correlation. Javed Mohammed Khan and Shoba Ranganathan. Macquarie University, Sydney, Australia. firstname.lastname@example.com. E. C. A. D. B. - PowerPoint PPT Presentation
A multi-species comparative structural bioinformatics analysis of inherited mutations in a-D-Mannosidase reveals strong genotype-phenotype correlationJaved Mohammed Khan and Shoba RanganathanMacquarie University, Sydney, email@example.com
a-D-MannosidaseLysosomal a-mannosidase acts to degrade N-linked oligosaccharides or mannose-rich compounds.The deficiency of this enzyme results in a recessively inherited lysosomal storage disease, called a-mannosidosis.Mutations in the gene (MAN2B1) encoding lysosomal a-D-mannosidase cause the disease.Structure of bovinea-D-mannosidase shows five chains held togetherby four disulfide bonds.Missense, nonsense, insertions, deletions and also some splicing mutations.
Phenotypes and species affectedCoarse face, prominent forehead, mental retardation, skeletal malformation, hearing loss and cerebral dysfunction leading to paralysis and death1. A severe infantile formLeads to early deathA mild juvenile form Survival into adult lifeDomestic cats, cattle and guinea pigs.First characterized in humans by Ockerman in 19672.Malm D, Nilssen : Alpha-mannosidosis. Orphanet J Rare Dis. 2008, 3:21. Ockerman PA. A generalised storage disorder resembling Hurler's syndrome. Lancet. 1967;2:239. Artemisia annua
Why study a-D-mannosidosis?It can be comparatively well studied due to its occurrence across various species.Clinicians, geneticists and molecular biologists have not been able to correlate the genotypic mutations with the observed phenotype1, 3. The high phenotypic variability, has so far prevented adoption of a standardized clinical typing.a-mannosidosis occurs in 1 of 500,000 live births1.Errors of lysosomal metabolism occur in approximately 1:5000 live births.This approach can be extended to other lysosomal disorders.Malm D, Nilssen : Alpha-mannosidosis. Orphanet J Rare Dis. 2008, 3:21.Lyons MJ, Wood T, Espinoza L, Stensland HM, Holden KR: Dev Med Child Neurol 2007, 49:854-857.
Our approachUse protein structure to unravel how the mutations affect the function of the enzyme, especially with respect to the enzyme active site, to explain observed phenotypes.Data sources for mutationsOMIM: Online Mendelian Inheritance in ManPublications from PubMed. OMIA: Online Mendelian Inheritance in AnimalsSequence informationGenBank, Swiss-ProtSequence alignment and visualizationCLUSTAL, WEBLOGO3D structural modelingMODELLER3D structure assessmentBiotech Validation Suite
Issues related to modelling The X-ray crystal structure for bovine lysosomal a-D-mannosidase (PDB ID: 1O7D)4 lacks: Two of the four vital disulfide bonds (as annotated by Swiss-Prot). A few structurally and functionally important residues.
MAN2B1 produces a five chain protein.
Existence of 11 essential ligands.
Presence of cleavable signal peptide (50 AA) in database sequences and water molecules in 3D structure.
Swiss-Prot and WEBLOGO depict a well conserved propeptide region. Heikinheimo P, et al.: J Mol Biol 2003, 327:631-644.
What is the solution?A single comprehensive molecular modeling procedure.
Addresses all the issues related to a-D-mannosidase modeling. Rebuilt the two missing disulfide bridges along with all the existing ligands.
Assessment of the Wild-Type structural models High degree of similarity between target and template sequences and strict modeling protocols adopted.
Excellent RMSD and WHATIF Z-Scores.
Above average PROVE Z-Score and PROCHECK validation results.
Generation of high quality WT models.
Mapping mutations to WT structural models We have constructed a mutation map mapping available mutations in the context of the enzyme active site to understand where the observed mutations occur Most mutations with lethal phenotypes are located in and around the active site. Thereby affecting the functionality of the enzyme.
Genotype-Phenotype correlation The three phenotypes correspond to Type 3, Type 2 and Type 1 clinical phenotypes described by Malm and Nilssen1. Mapped all truncation mutations to different chains of human WT protein. Malm D, Nilssen : Alpha-mannosidosis. Orphanet J Rare Dis. 2008, 3:21.
Prediction of potentially harmful mutations Highly conserved sequence across all species. Almost all mutated residues causing fatal/harmful phenotypes are highly conserved. All these positions can be considered potential disease-causing mutations for all mammals represented here. Mutations in residues comprising the active site of the enzyme could have serious effectsThis residue set represents a structurally-derived mutation hot-spot.
Sequence-based mutational hot-spot regions in the MAN2B1 gene Mutations are scattered along the length of the gene. Mutations seem to cluster into groups over segments of varying sequence length called mutational hot-spot regions. Five distinct mutational hot-spot regions with lengths varying from 117 to 606 nucleotides. Residues coded for by the nucleotides within the range 961-1204 are most likely to undergo mutations. Occurrence of a harmful mutation is most likely to be between 157-323, 562-679 and 961-1204 hot-spot regions due to their close proximity to the active site.
Significance of this studyCan be used as a predictive approach for detecting likely -mannosidosis across various species.
Novel prediction protocol for new disease mutations related to -mannosidosis.
Approach can be extended to other inherited disorders.
Provides a way for detecting mutation hotspots in the gene, where novel mutations could be implicated in disease.
A rational approach for predicting the phenotype of a disease, based on observed genotypic variations.
ConclusionsEstablishes a significant correlation between the genotype and the phenotype of the disease.
Highlights the effect of disease mutations on protein structure and forms the basis for understanding the molecular determinants for phenotypic variations.
High degree of mutational heterogeneity of -mannosidosis is comparable to that observed in many other lysosomal disorders.
Suggests that rather than drug/inhibitor design, this disease could be tackled through gene therapy.
This study could play a vital role in developing therapies for inherited diseases.
AcknowledgementsProf. Shoba Ranganathan.Macquarie University for MQRES scholarship.Colleagues and friends at Macquarie University.The InCoB 2009 program and organising committees.
Questions ?
RecommendedView more >


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You have learned how to combine talents from the Mithral Current and Steel Serpent disciplines.
Prerequisites: Quick Draw, two Mithral Current maneuvers known, two Steel Serpent maneuvers known.
Benefit: Whenever you use a Steel Serpent maneuver to deal ability score damage to a creature with vulnerability to silver, increase that ability score damage by 50%.
Section 15: Copyright Notice
Path of War – Expanded, © 2016, Dreamscarred Press.


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First Unitarian Universalist Church 1808 Woodmont Blvd, Nashville.
+ Event Details
A chance to restore and nourish those who give in their work, family and community and need a chance to recharge. Appropriate for all bodies and experience. Energizing poses, relaxing poses, breathing techniques, guided relaxation, and simple meditation techniques to stimulate the relaxation response and give the nervous system a chance to renew and refresh. Email to reserve your space in one or all of the month-long series.
First Unitarian Universalist Church 1808 Woodmont Blvd, Nashville.


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We had so much fun hanging out at Treehouse Adventure Park! What a great team-building activity!!
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0:54 Age and weight restrictions
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3:40 They can accommodate large groups!GO OUT ON A LIMB at Treehouse Adventure Park!
– – –
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Want more Keeping Up With The Community?
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Enter characters name to personalize each & every descriptions on this page to your character.
An earth sciences aptitude represents a skill in... further description to come.
Below you will find an initial list of site-sanctioned Aptitudes and Skills for your character application.
Note - If you are logged in to Marvel RPG, each entry shown below may already be personalized to reflect your character"s codename and gender. If not, then they are shown in a generic format, but you can still set them to reflect your characters gender and codename by using the customizer located just above the catagory legend. Doing so will will instantly then format all the descriptions to your specifications to help you on your way to building an awesome addition to the Marvel RPG universe.
Agriculture: (#110)
Deals with field crop production and soil management Also, a combination of the producing operations of a farm, the manufacture and distribution of supplies, and the processing distribution and storage of such supplies. The development and repair of farm equipment, irrigation systems and landscape planning. Can also include forestry, the science of developing, caring for and cultivating forests and/or timberlands.
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Study of weather systems.
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The study of metal and its practical uses.


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Some of the latest theories and research on persistent pain…Read More
The Power of the Vagus Nerve
Let's explore the powerful impact that yoga has on our Vagus nerve and parasympathetic nervous system…Read More
Why our intervertebral discs cannot slip!
Let's take a look at the inner workings of our spine and discuss the latest research on this fascinating area.Read More
Why is Wrist Pain So Common in Yoga?
A lot of yoga students, particularly those who are new to the practice, complain of wrist pain…Read More
What Limits Our Movement?
Let's discuss how each of our bodies are so unique and what can limit our range of movement in yoga…Read More