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Spinal Product
Dorn Spinal Therapy
Dorn Spinal Therapy has been in uses in the past 40 years. The credit of this method goes to Dieter Dorn, who has made a significant impact in the medical field. DORN- Method has been used on various patients where results could get witnessed instants. Due to the impact, this method has brought in the country. It has been declared the standard practice in treating Pelvical Disorders, Spinal, and Back pain. Dieter Dorn first used this method on his family, which was a sign of confidence in a method, which later gained much attention from different people in the country and also globally. Every day Dorn was able to offer treatment to 15- 20 patients in a day. His services were purely free which attracted attention both in the local and also global. The primary treatment that DORN-Method which could be treated using this method include spine healing therapy, misalignments of the spine, resolving pelvis and joints, and also solving out significant problems which could get attributed to vertebrae. Read more...
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Color Changes in Old Aposematic Thorns Spines and Prickles
While the adaptive significance and the broad occurrence of color change in flowers (Weiss 1991, 1995) fruits (van der Pijl 1982 Willson and Whelan 1990) and leaves (Matile 2000 Archetti 2000 Hamilton and Brown 2001 Hoch et al. 2001 Lee et al. 2003 Schaefer and Wilkinson 2004 Lev-Yadun and Gould 2007) has been widely discussed, the phenomenon of color change in thorns, spines and prickles has only recently been described as being a widespread phenomenon and discussed as such (Lev-Yadun and Ne'eman 2006). Patterns of color changes of senescent colorful aposematic thorns, spines and prickles were described in Lev-Yadun and Ne'eman (2006) Color changes make them less conspicuous, and they lose most or even all their aposematic character. The scale of this phenomenon on a taxon, flora, continent or global scale is still unknown. Lev-Yadun and Ne'eman (2006) emphasized that color changes in thorns, spines and prickles are not mandatory. Color changes and the aposematic character losses...
Anthemideae Biological And Systematic Review
A number of pollen studies have been conducted in the Anthemideae, using both light and electron microscopy, and many of these studies have been concerned with the characterization and identification of Artemisia pollen (Skvarla et al., 1977). Stix, (1960) recognized two basic pollen types in the Anthemideae, Anthemis and Artemisia, distinguishing them by spine presence in the former and absence or great reduction in the latter. Floral modification characteristic of anemophilous species include inconspicuous often pendulous capitula and florets, loss of nectar production and dry spineless pollen, in contrast with the sticky spiny pollens of the entomophilous genera (Skvarla and Larson 1965).
Robles encinas encinos belloteros [acorntrees Quercus speciesBeech family Fagaceae
Scrub oak, encino achaparrado shrub-size oak Quercus turblneli Range Our whole range w to CA s. to Mex. Dry slopes, 4,500' - 8,000' This oak should be readily identified by its small, somewhat shiny, bluish green, hollylike leaves with spine-tipped teeth arid dull yellow to reddish, hairy undersides.
Mimosa biunciferaPea Family
This shrub urges passersby to wait a minute by sinking its cat-claw spines into clothing or flesh. Even the leaves and pods are prickly with tiny, curved spines. Because the stem spines are curved and paired (two at every node), wait-a-minute bush is easy to distinguish from catclaw (which has one curved spine per node) and white thorn (which has paired, straight spines). Wait-a-minute leaves are divided into tiny leaflets, as many as three hundred per leaf. New leaves appear rather late in the spring and are retained all summer. They turn brown with the first frosts and drop soon afterward. Flowers are borne between May and August. Even without flowers and leaves, the five-foot-tall shrubs are readily recognized by their paired, catclaw spines and tendency to grow in impenetrable thickets. Wait-a-minute thrives on hillslopes and in washes from Arizona to Texas.
Parrot Pitcher Plants
Lacking the spine-lined mouth of the purpureas, the parrot, Sarracenia psittacina Michaux, has evolved a somewhat different, yet equally effective, insect-confusing method of getting fed. The flared hood is up, the mouth toward the center of the plant. As insects are attracted into the tiny mouth by the aroma from the attractant glands, they begin to feed on the nectar of the plant. If they suspect something awry, the insects may attempt to flee. But which way is out Not up, although there's light showing through those translucent spots. It may fly up, but merely hits its head and tumbles back into the pitcher.
Upright Thorny Plants
Recognition I'hough the cherries, also in the genus Prunus9 are never spiny, the plums are variously thorny or not, Alleghany Plum (p. 240), for example, sometimes has spine-lipped twigs. For upright cherries and such usually thornless plums see Plate 53, Some spines of plums may be simple spikes, but most are short, stiff, bud-bearing branches with sharpened tips. Thorns are generally absent from young twigs- Like other species of Primus, leafstalks of most plums (but see American Plum) bear paired small glands. Sap clear and spur brandies often present. Bark often marked with horizontal line-like lenticels. Unlike cherries, the end buds are false in plums. Wild plum fruits are small, ball-shaped, with single large seeds.
Water Use Efficiency Of Fossil And Herbarium Plants
A large amount of time exists between the origin of land plants and the evolution of leaves with a flat blade (Kenrick 2001). For at least the first 40 million years of their existence, land plants were leafless or had only small spine-like appendages. The widespread appearance of megaphyll leaves, with their branched veins and planate form, did not occur until the close of the Devonian period about 360 million years ago (Beerling et al. 2001). (See Figure 9.10 for a figure of the geological time scale, which shows the Devonian period.) Beerling et al. (2001) proposed an explanation for this long delay. Drawing on anatomical and environmental data from the fossil record, they concluded that leaves with a broad lamina evolved in response to a massive drop in atmospheric CO2 during the Late Devonian period. The evolution of the megaphylls coincides with a drop of around 90 in atmospheric CO2 concentration (Beerling et al. 2001 Kenrick 2001). The fall was driven by plants. The evolution...
Eric Mellink andMnica E Riojas Lpez
Consumption of Vegetative Structures Cladode Preferences Seasonal Effects for Herbivory Nutritional Qualitites of Cladodes Spine Effects on Herbivory Consumption of Reproductive Structures Flower Consumption Fruit Consumption Evolutionary and Ecological Context Past and Present Herbivory Pressures Gal pagos Islands Alienized Relations Concluding Remarks Literature Cited
Microtubules as Sensors Molecular Mechanisms
These pharmacological findings from plant cells are supported by the results from genetic screens for touch-sensitive ion channels in Caenorhab-ditis elegans. Using a system, where the phobic response to a specific touch stimulus was screened, so-called mechanosensation defective (mec) mutants could be recovered (Chalfie and Au 1989 for review see Chalfie 1993). Some of the mutated genes encoded a novel class of transmembrane proteins, the so-called degerins, that might represent components of a touch-sensitive ion channel. However, two of these mutants, mec7 and mec12 were affected in a unique set of microtubules consisting of 15 protofilaments that were confined to the axons of the touch-sensitive neurons responsible for the phobic response (Chalfie and Thomson 1982). MEC12 and MEC7 were later shown to encode specific isotypes of a-tubulin (Savage et al. 1989) and -tubulin (Fukushige et al. 1999), respectively. In both mutants, the loss of mechanosensation was correlated by specific...
Central depressive effects of Magnolia extracts 4421 Muscle relaxant effect
The ether extract of Magnolia and the alkali-soluble fractions inhibited the spinal reflexes, the crossed extensor reflex responding to the stimulation of the central end of the cut sciatic nerve, in young chicks (ED50 48.8 mg kg and 21.2 mg kg, respectively) (Watanabe et al., 1973). This effect was antagonized by strychnine (0.5 mg kg i.p.). The tonic extensor convulsion produced by intracerebroventricular injection of penicillin G potassium (50 ig) in mice was also inhibited by Magnolia ether extract (ED50 530 mg kg) and its alkali-soluble fraction (ED50 251 mg kg).
Central depressive effects of magnolol and honokiol
Watanabe et al. (1975, 1983a,b) evaluated in detail the central depressive effects of magnolol and honokiol. Both intraperitoneally administered magnolol and honokiol disrupted the grip strength in mice for up to 180 min (ED50 131 mg kg and 217 mg kg, respectively) (Watanabe et al., 1975), and inhibited the spinal reflexes in chicks for up to 60 min (ED50 10.3 mg kg and 11.1 mg kg, respectively) (Watanabe et al., 1983a). Magnolol also inhibited penicillin G potassium-induced convulsions in mice (ED50 31.3 mg kg) (Watanabe et al, 1983b).
Mechanisms of the central depressive effects of magnolol and honokiol
Neurochemical evaluation revealed that honokiol (1-10 iM), but not magnolol (1-10 iM), elicited a concentration-dependent enhancement of 25 mM K+-evoked acetylcholine (ACh) release from rat hippocampus slices (Tsai et al., 1995b). Addition of tetrodotoxin (1 iM), pilocarpine (1 iM) or methoctamine (1 iM) had no effect on the enhanced ACh release by honokiol. These results indicate that part of the central depressive effect of honokiol is produced through an enhancement of K+-evoked ACh release directly on hippocampal cholinergic terminals via receptors other than M2 cholinergic subtypes. Taken together, the results from the behavioral, electrophysiological and neurochemical evaluations strongly suggest that magnolol and honokiol show an inhibitory effect on several areas of the brain such as the hypothalamic and reticular formation ascending activating systems as well as the spinal cord.
Echinocactus horizonthalonius
Well known among the desert figures are the heavy-bodied barrelcac-tuses which are sometimes pointed out as sources of water for travelers suffering from thirst. Under extreme conditions, it is possible to hack off the tops of these tough, spine-protected plants and obtain, by squeezing the macerated tissues, enough juice to sustain life.
Larval Fish In Estuarine And Coastal Waters
24-25 myomeres body depth moderate lightly pigmented gut coiled and compact conspicuous gas bladder small preopercular spines. (Figure 8.12P) Typically 30-40 myomeres body elongate lightly to moderately pigmented gut short and coiled moderate to large teeth none to large preopercular spines. (Figure 8.12I) 24-25 myomeres body depth moderate lightly pigmented gut moderate coiled and compact prominent ascending premaxillary process small preopercular spines. (Figure 8.12O) 24-25 myomeres body depth moderate lightly pigmented gut moderate, coiled and compact small to large preopercular spines. (Figure 8.12L) 26-27 myomeres body depth moderate lightly to moderately pigmented gut moderate, coiled and compact small preopercular spines. (Figure 8.12S) 19-20 myomeres body deep and laterally compressed moderately to heavily pigmented gut moderate, coiled and compact prominent dorsal and pelvic spine with barbs. (Figure 8.12E) 24 myomeres body deep and laterally compressed moderately to heavily...
Partial Descriptions ofColor Patterns in Floras
One major obstacle to studies of defensive plant coloration in general and apose-matic coloration in particular is provided by the fragmentary and inconsistent descriptions of plant coloration, especially of vegetative organs. Taxonomists have usually referred only to flower colors, and even this character has not always been fully described. Thorn, spine and prickle color, unripe and ripe fruit color, leaf colors, bark color and color changes in all of these organs have usually not been systematically described. In his seminal book on plant demography, Harper (1977) commented as follows on the possibility that defensive plant coloration operates botanists were reluctant to accept things that are commonplace for zoologists. The surprisingly small number of papers in botany related to defensive coloration
Immunocytochemical localization of capsaicin VR1TRPV1 receptors
VRl-immunoreactivity and mRNA for VR1 positive neurons in rat and human brain were scattered in different regions, including the preoptic area of the hypothalamus. The strongest VR1 mRNA signals were detected in the following areas all cortical areas, septum, hippocampus dentate gyrus, substantia nigra (zona compacta), cerebellum, locus coeruleus and inferior olive. In rat hypothalamus VR1 mRNA-expressing neurons and capsaicin-induced glutamate release have been reported (Sasamura et al., 1998). It was striking that in rats treated with capsaicin in the neonatal age, although VR1 mRNA in DRG and nucleus of the spinal trigeminal nerve was diminished, its expression in other areas of the brain did not differ from that of the controls (Mezey et al., 2000).
Echinocereus fendleri a
Growing in open clumps with stems resembling spine-covered cucumbers standing on end, the hedgehog is the first cactus to blossom in the spring. Flowers vary considerably in color ranging from lavender through purple to a rich red. A closely related cactus, the rainbow (Echinocereus rigidissimus) (b) is restricted in its distribution to elevations between 4,000 to 6,000 feet. It is called rainbow cactus because of alternating bands of red and white spines encircling the stem and marking growth of different seasons and years. Its blossoms are pinkish (yellow in western Texas) and are large and showy in comparison with the small size of the single-stemmed plant.
OfAposematic Coloration in Thorny Spiny and Prickly Plants
There is very strong indirect evidence for the operation of aposematic coloration in thorny and spiny plants and its convergent evolution in the fact that conspicuous thorn and spine coloration is found in angiosperm taxa that have mutually exclusive biochemical pathways of pigmentation. For instance, taxa belonging to the Caryophyllales (e.g., Cactaceae, Caryophyllaceae, Chenopodiaceae) produce yellow and red pigments via the betalain pathway (Stafford 1994) . Most other angiosperm families use anthocyanins for similar patterns of coloration. The fact that spines of cacti are usually conspicuous because of their coloration (Lev-Yadun 2001), commonly including yellow, orange and red coloration resulting from betalain derivatives, indicates that this group of pigments may, among their various functions, be involved in aposematic coloration. By contrast, in Rosaceae, Asteraceae and Fabaceae as well as in many other angiosperm families that use anthocyanins for yellow, orange, pink, red,...
Aposematic Coloration in Thorny Spiny and Prickly Plants
There are three terms for sharp defensive plant appendages thorns, when they are made of branches spines, when they are made of leaves and prickles, when they are made of cortical tissues (e.g., in roses). Thorns, spines and prickles provide mechanical protection against herbivory (Janzen and Martin 1982 Janzen 1986 Tomlinson 1990 Myers and Bazely 1991 Grubb 1992 Rebollo et al. 2002) because they can wound mouths, digestive systems (Janzen and Martin 1982 Cooper and Owen-Smith 1986 Janzen 1986), and other body parts of herbivores. Thus, theoretically, once herbivores learn to identify thorns, spines and prickles (and their bright colors or associated markings should help in their recognition), they can avoid the harmful plants advertising them. The fact that thousands of Since what is toxic to one animal might be harmless to another (Laycock 1978 Janzen 1979 Gleadow and Woodrow 2002), chemical-based aposematism may not operate for all herbivores. For sharp defensive organs, the...
Glycine And Dimethylglycine
Glycine, because of its effects on this one area of the brain, can be used as an adjunctive treatment in several conditions. In people suffering from drug and alcohol dependency, it is thought that this area of the brain is periodically up-regulated, leading to excessive norepinephrine release. People who become dependent on substances may use drugs or alcohol to satisfy the cravings created by an up-regulated locus ceruleus. Other conditions in which glycine can be useful for down-regulation of the locus ceruleus are panic disorders, nervous tension, anxiety, substance withdrawal, and insomnia (which is marked by awakening with anxiety). Glycine also interacts in an inhibitory action with motor neurons in the spinal cord and can have a calming effect on muscle spasms, muscle twitching, guarding, and rigidity that results from excessive spinal reflex activity. Glycine can inhibit spasms associated with the urinary and reproductive systems as well.19
Sperm cell male gamete
alveolate angulaperturate annulate annulus aper- arcuate arcus areola areolate atectate atrium cate boat-shaped brevi- brevicolpate brevicolporate pa cappula caput cavea caveate circular clava is colpus colpus membrane columella columellate costate croton pattern cryopalynology cup-shaped diporate dispersal unit distal disulcate dyad echinate ure elliptic endexine endintine endo- endoaperture il view eu- eurypalynous eutectate exine fenestrate i foveola foveolate free-standing columellae frustrate granular granulate granulum haploxylon-pollentype ropolar hexa- homo- homobrochate iatropalynology um intectate inter- interapertural area intercolpium iso- isodiametric isopolar lacuna laesura lalongate lophae lophate lumen margo massula melissopa- ocolpium micro- microspore microspore mother cell noporate monosaccate monosulcate muri nexine Derculate operculum orbicule ornamentation outline sopalynology palynogram palynology palynomorph pedium penta- perforate peri- pharmacopalynology te...
Pathogenic Bacteria and Fungi and Thorns
Three recent publications showed that spines harbor an array of pathogenic bacteria and fungi (Halpern et al. 2007a, b Lev-Yadun and Halpern 2008). Spines from date palm (Phoenix dactylifera) trees, thorns from common hawthorn (Crataegus aronia) trees and two thorny shrub species, thorny burnet (Sarcopoterium spinosum) and manna tree (Alhagi graecorum), were sampled in Israel. Every typical mature individual of these trees and shrubs carries hundreds or even thousands of conspicuous and therefore potentially aposematic spines or thorns. The severity and frequency of infections among orchard workers in Israel following date-palm spine wounding has necessitated the costly practice of removing all of the millions of spines from many of the orchards using mechanical saws. Even the small number of spines and thorns studied resulted in a list of aerobic and anaerobic bacteria species including Clostridium perfringens, Bacillus anthracis and Pantoea agglomerans (Halpern et al. 2007a, b). C....
A particularly striking example of the hexagonal arrangement of baculae is provided by the immature pollen of Ipomea purpurea (Fig. 4D). In this species, the reticulate pattern of the tetrad stage microspore is remarkably consistent of the 54 complete elements that make up the spore face depicted in Fig. 4D, 48 are regular hexagons. However, it is noteworthy that the pattern is not quite perfect since six of the constituent elements are pentagonal. Another interesting feature of Ipomea is that almost every three-way intersection (triple junction) between the polygonal elements carries a spine. These examples demonstrate that pattern specification involves the precise positioning of wall elements, principally baculae, and that the unit of pattern is very often a regular hexagon. Fig. 4. Reticulation in pollen walls, bubbles and basalt. A. Scanning electron micrograph (SEM) of Lilium pollen wall showing reticulate pattern formed by the baculae. The nexine I is visible through the...
Endometriomas are commonly found on the ovaries fallopian tubes peritoneal lining cervix colon appendix vagina and uterosacral, broad, and round ligaments. In severe cases, adhesions are also found on the bladder, kidney, vulva, arms, legs, lungs, nasal mucosa, spinal column, and sites of previous surgical incisions.2 Two-thirds of women with endometriosis have their ovaries affected in 30 of women, local lymph nodes are involved and in 10 -15 of women, the sigmoid colon is affected.2
These are known to be analeptic and convulsant and are medullary stimulants. As analeptics they were used to overcome depressions due to overdoses of barbiturates or morphine, but this is now mostly abandoned because of their high toxicity. They act on the spinal cord by antagonizing or blocking postsynaptic inhibitions. Brucine has a similar action to strychnine but is fifty times less toxic. Picrotoxin, obtained from the Indian Anamirta paniculata, is a medullary stimulant in small doses and is used in preference to strychnine to counteract barbiturate and bromide poisoning. The West African Dioscorea dumetorum (Dio-scoreaceae) has a picrotoxin-like convulsive action on the medulla.
Adult Dark brown with pointed tails at the end of the vein 2,4 of the hind wing. Both wings are crossed by yellow bands, which in the forewing is made up of separate discal spots. Wings span 7.5-8.0 cm. (Plate 9.2). Egg Spherical and white,with brown streaks. Larva The caterpillar is characterized by long, paired filaments, a branching spine or a horned head. There are two pairs of filaments on its head the center pair is longer than the adjacent ones. Between the center pair there is another short pair showing as horns. The tips of these filaments are reddish brown. The posterior end has one pair of appendages which are brown at the tip (Plate 9.3). These appendages disappear in the last larval stage. The body is dark green with a yellow line that runs laterally across the body. A fully grown larva is 5.5-6 cm, and has 3 pairs of legs and 5 pairs of prolegs. Pupa Green color, 2-2.5 cm, oval shape pointed at one end.
There was no apparent vitamin B12 deficiency, although there were changes in the patients' electroencephalograms along with mental changes.31 Citing the causal link between vitamin B12 deficiency and brain dysfunction, the authors of this study suggest that the manifestation of psychiatric symptoms may occur prior to other standard signs such as macrocytic anemia and spinal-cord disease, and that all patients with psychiatric disease should be evaluated for vitamin B12 deficiency.
Its dark gray bark makes this intricately branched shrub appear black from a distance, creating a rather somber landscape. When it blooms in April and May, however, blackbrush is quite pretty. There are no petals the four sepals, all bright yellow on the inside, take over the function of petals, attracting pollinators to the cluster of stamens and pistil in the flower's center. The tiny leaves are gray and arise in pairs on the spine-tipped branches.
The Opuntia group has approximately three hundred species of cacti or more, and typical members of subfamily Opuntioideae have well-defined stem segments, an unusual kind of specialized seed structure, and a unique type of reverse-hooked small spines (glochids), which penetrate the skin and are easily dislodged from their attachment points in the areoles. These cacti include the prickly pears and chollas (pronounced CHOY-yas), which produce showy flowers that are often pollinated by bees, and develop fleshy (occasionally dry) edible berries called tunas. This group is the most widespread of any in the Cactaceae, ranging from southern Canada southwards almost continuously to the cold habitats of Patagonia in southernmost Argentina. They are found from sea level to high elevation (4,000 meters and higher) and have adapted to a wide variety of habitat types. Species of Opuntia introduced into suitable habitats in Africa and Australia have become noxious invasive pests, and removing these...
Free Radicals
Free radicals are believed to play a role in the pathogenesis of MS. Persons with MS have elevated concentrations of markers of nitric oxide (NO) production, including nitrate and nitrite, in their cerebrospinal fluid (CSF), blood, and urine. Research suggests that NO has a role in the axonal degeneration and impairment of axonal conduction, disruption of the blood-brain
S Wats Irwin Barnb
In the spring, the bare stems put out flowering shoots adorned with pretty yellow flowers and sparse leaves. Each leaf is composed of four to six paired leaflets that drop within a month or two. Afterwards, the leaf axis remains as a feeble spine. Spininess is common among desert plants no one is quite sure why. Defense against herbivores is one suggestion. Anothei is that spininess is a consequence of the arid environment. What is certain is that desert plants arrive at spininess by several different routes. Some, like catclaw and white thorn, develop spines by modification of tiny leaf bracts called stipules. Others, like spiny senna, press the leaf stalk or the leaf axis into service.
Lecithin , phosphatidylethanolamine, phosphatidylinositol) extracted as a by-product during the degumming of crude soybean oil. It constitutes about 0.5-1.5 of the soybean seed or 1-3 of crude soybean oil. Commercially, lecithin is available from a dark-tan to reddish-brown colour and in a fluid state to powdered form it constitutes about 75 phospholipids, while the rest is unrefined oil, moisture and so on. Lecithin is an important nutraceutical component of soybean. It improves liver function, cardiovascular health, fetal brain development, memory function and the reproductive system. Lecithin is an indispensable component of cell membranes, constituting about 10 of the human spinal cord and 5 of the brain hence, its deficiency restricts the free passage of nutrients from and into the cells. Therefore, it is of great therapeutic value for patients with Alzheimer's disease who are deficient in the neurotransmitter acetylcholine. Lecithin is also recommended for relieving depression....
CII3CI Icilj
These seeds contain 1.5-5 of alkaloids, chiefly strychnine (about 1.2 ) and brucine (about 1.6 ). Strychnine (Fig. 2.6) is very toxic, affecting the CNS and causing convulsions. This is a result of binding to receptor sites in the spinal cord that normally accommodate glycine. Its only medicinal use is in very small doses as an appetite stimulant and general tonic, sometimes with iron salts if the patient is anaemic. Brucine (Fig. 5.14) is considerably less toxic. Distribution of strychnine and brucine in various species of Strychnos is tabulated below.
Prostrate Spurge
The bad-boy member of the family is leafy spurge (Euphorbia esula), an invasive weed of cattle rangeland that is so unpalatable that cattle won't even graze near it. Leafy spurge, then, shrinks the effective acreage available for feeding. The most useful member of the family is petty spurge (Euphorbia peplus), which is interesting for its oddly personified name, but useful because its milky sap can be used as an out-of-the-ground treatment for skin cancer lesions. The sap is applied to the lesion like liquid nitrogen, and like liquid nitrogen it causes skin blistering and cell death where it is applied. The cancer generally flakes off a week or so later. The milky sap is common to most members of the Euphorbia family. Break a leaf off your poinsettia and watch the sap run. Cactus-like members of the family can be distinguished from real cacti, whose family is conveniently called the Cactaceae. Euphorbia cacti are like cows they have two horns and give milk. (Translation The spines...
Bracts may be elaborate and persistent (e.g., Aechmea fasciata Fig. 3.2G), or much reduced and more ephemeral (e.g., Aechmea fulgens Fig. 3.2B). Ancillary functions characterize the exceptional species, for example the red bracts that also secrete nectar to attract ant guards to Tillandsia bal-bisiana (see below). Floral bracts produced by Aechmea setigera bear a sharp terminal spine that seems not to impede either pollination or seed dispersal, but may deter large grazers (Fig. 3.2D).
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Differential impact of aerobic fitness and muscular strength on bone health, body composition, physical function and patient reported outcomes in men with prostate cancer (#103)
Aim. To compare outcomes commonly affected by prostate cancer treatments between prostate cancer patients according to objectively measured levels of aerobic fitness and muscular strength. Methods. 386 men with localised prostate cancer (age: 69±8 years, BMI: 29±4, Gleason score: 7.6±1.3, time since diagnosis: 3.5±5 years) participated in this cross-sectional study. Participants had undergone or were currently undergoing androgen deprivation therapy (98%), radiation therapy (44%) and/or surgery (24%). Participants were assessed for aerobic fitness (400m walk), muscular strength (1 repetition maximum of leg press and chest press), bone mineral density (whole body and lumbar spine), body composition (dual-energy x-ray absorptiometry), physical function (repeated chair rise, stair climb, 6m usual pace, fast pace and backwards walk, sensory organisation test for balance), quality of life (SF-36, QLQ-PR25) and psychological distress (BSI-18). Comparisons were made between participants with higher and lower aerobic fitness and muscular strength based on the respective median scores. The difference between higher and lower groups was determined by ANCOVA controlling for age, education, smoking status, number of comorbidities and treatment history. Results. Superior aerobic fitness and muscular strength were both associated with significantly (p≤0.05) better physical function (p<0.001-0.041 across all assessments), quality of life (general health, physical function, role-physical, bodily pain, vitality and mental health domains = 2.8-4.6 NBS, 95%CI:0.1–4.1) and predicted monthly medical expenditure (-$77 to -$103, 95%CI:-$50 to -$156). Men with higher muscular strength had significantly superior BMD (0.035-0.039g/cm2, 95%CI:0.007–0.070) and lean muscle mass (2.4-4.6kg, 95%CI:1.7–6.3) but not fat mass. Men with higher aerobic fitness had significantly lower fat mass (-2.6 to -4.2kg, 95%CI:-1.5 to -5.9), but not BMD or lean mass. Conclusions. Higher aerobic fitness and muscular strength confers considerable benefits to physical function, quality of life and medical costs but have specific effects on bone health and body composition in prostate cancer survivors.

subset: commoncrawl


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Funniest female comics on a Norwich stage
PUBLISHED: 09:20 05 March 2013 | UPDATED: 10:14 05 March 2013
The ever popular Lady HaHa returns to Norwich this week offering a unique chance to catch a line-up of the UK's funniest upcoming female comedians. HOLLY HAYMAN reports.
If you fancy getting a glimpse of the future female stars of stand-up comedy before they make it big, uniquely, Norwich is the place to do it.
Held annually on International Women's Day, Lady HaHa is an evening of stand-up comedy from the UK's most talented up and coming female comedians.
Since 2010, Lady HaHa has been showcasing funny ladies before they hit the big time; blink and they'll have made the mainstream breakthrough and gone sky high and expensive.
Since its beginning, Objective Talent Management's Corrie McGuire has been responsible for putting the show together.
Although working with some of the biggest performers in the business, including Derren Brown, she is also on the lookout for anyone "whose star is on the rise and who's new and exciting."
She explains "There are some brilliantly talented female comedians on the circuit but you'll rarely find more than one on a comedy club bill."
She adds, "Lady HaHa has been a huge success, which proves there's an audience out there for a more female friendly night."
The latest Lady HaHa returns to the Playhouse on March 8 with four more funny females you'll want to keep track of.
It will include an appearance from currently the funniest upcoming female on the comedy block in Aisling Bea the winner of the So You Think You're Funny Award 2012. The Irish comic b3ecame only the second woman to have won the prestigious wards in the 25 years that Edinburgh Fringe venue Gilded Balloon has been running the contest. And her triumph came a full two decades since Scottish female comedian Rhona Cameron took the coveted comedy prize.
She will be joined by the hugely enjoyable class-conscious comedy will be Tiffany Stevenson, who has previously appeared as a comedy actress in The Office and Absolute Power, and super funny new girl on the block Amy Howerska who was raised in Wales by a Polish, Irish, Catholic Jewish family, which certainly giving her comedy stylings unique origins.
And making her second Lady HaHa appearance will be musical comedian Vikki Stone who's mix of stand-up and musical comedy has made her one of the fastest rising stars of the comedy circuit.
Her debut Edinburgh Show, Big Neon Letters, played to sell-out audiences both in Edinburgh and London's Soho Theatre, and received critical acclaim including The Observer's Comedy Top 5 Edinburgh Shows in 2011. While her follow up, Hot Mess, sold out its entire run at the Edinburgh last summer and her Phillip Schofield Song became an online viral hit.
Reminiscing on her most memorable moments since first visiting Norwich for Lady HaHa in 2010 she saidL: "Probably ersuading Philip Schofield to be in the video for the song I wrote about him, and writing a bespoke song for Dragon's Den star Hilary Devey. Let's just say I've been slowly taking over the world, one funny song at a time."
Originating in 1911, International Women's Day was created to recognise suffrage and the economic, social and political developments of women.
Chosen to honour and inspire women and their achievements, Lady HaHa's past performers have included Isy Suttie, now a household name starring as the hilarious Dobby in Peep Show and the current series of Shameless; Holly Walsh, who has gone on to become a TV panel show regular, including stints at the desks of 8 Out of 10 Cats, Mock the Week and Never Mind the Buzzcocks; Susan Calman, who has appeared on Have I Got News For You, QI, The News Show as well as earning her own Radio 4 show, Calman Is Convicted.
Vikki Stone's advice on becoming a female comedy superstar is simple. "Be the funniest you can be, whilst also being yourself. There are no rules, so there's no need to try and conform to any."
t Lady HaHa, Norwich Playhouse, March 8, 7.30pm, £10.50, 01603 598598, www.norwichplayhouse.co.uk


text:
The second attempt at filling vacant posts for Mathematics and Science teachers for government primary schools turned out to be a futile exercise, as more than 1,200 positions are still lying vacant at the end of the recruitment process that completed this week.
The Gujarat Education Department had invited applications for filling 6,000 vacancies for Mathematics and Science teachers (vidyasahayaks) in the month of November last year. These posts were re-advertised after the Department failed to fill them within August that included recruitment of 8,800 vidyasahayaks. Despite repeated attempts to call in candidates from the waiting list for these subjects, these posts could not be filled.
This time, of the 6,000 posts, the Department failed to fill nearly 20 per cent, amounting to 1,218 vidyasahayaks across the state.
"At present, the department is not sure how to fill these posts that have again fallen vacant for the second time. Whether there will be re-advertisement or these vacant posts will be carried forward to the next recruitment drive is uncertain at the moment," stated a senior official.
After the implementation of Right to Education Act in 2010 in Gujarat, the Education Department went on a drive to create and fill posts for primary government teachers. The recruitment of 6,000 posts was the third round of appointments of vidyasahayaks in the past two years, majority of which was in the three subjects of Mathematics, Science and Social Studies.
While some are presuming that the choice of districts offered to the candidates against their merit list is one of the reasons for these posts lying vacant despite repeated attempts, others are contemplating the tough stand taken by the Department against Mathematics and Science teachers.
"There are a few factors attributing to this issue. One could be that the number of candidates with the eligibility criteria of combination of B Sc (Maths/Science) and B Ed who have also cleared the Teachers' Aptitude Test (TAT) is not much. Not many candidates with a B Sc degree want to pursue teaching as a profession," said Gujarat Primary Teachers Association president Chandu Joshi.
Elaborating on other issues, Joshi added, "Most of the applicants are already teaching at a government or private school and don't want to change the district. If they are offered posting in a different district, they usually opt out. Moreover, they are also offered better pay packages by private schools, which again keeps them from accepting the posting."


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Ways of professionally important skills development of the future foreign language teacher at the initial stage
the article deals with the necessity of organization of professionally oriented training for students, future teachers of a foreign language, from junior courses. The minimum of professional skills that the students must master at the initial stage is allocated. The ways of forming the allocated skills are proposed, and algorithms for working with them are also considered.more


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Tube Amps / Music Electronics
|For current discussions, please visit Music Electronics Forum.
|New: view Recent Searches.
New: visit Schematic Hell!
The sunn still shines online!
|Listen to great tunes streaming live right now!
|Steve Ahola
|PRS 5-Position Selector Switch wiring diagram
* * * * * * * * * * * * * * * * * * * * * * * * *
5 POSITION PRS-STYLE SELECTOR SWITCH FOR 4+ HB's
* * * * * * * * * * * * * * * * * * * * * * * * *
* These colors are correct for SD Hot Rails and
Cool Rails pickups with SD logo right side up on
coil nearest the bridge. Be SURE to check the coils on your guitar before proceeding and substitute color codes as needed.
* * * * * *
Final note: While this is an exact simulation of
the PRS 5 position switch wiring, you may want to
test out other linkages before soldering up your
MegaSwitch. For Position 3, you may prefer the
sound of the OUTSIDE coils in series, which is
brighter and with more bass response (especially
on a strat-style guitar). You may also prefer to
substitute OUTSIDE coils in SERIES for the INSIDE
coils in PARALLEL for Position 2. On a strat, I
find that the outer coils have more definition
than the inner coils, and that series linkage
produces a stronger sound than parallel linkage.
To experiment, get a package of microtest clip
(Radio Shack #270-355) and try out different
combinations of coils until you find the sounds
that you like.
. Steve Ahola
|J Epstein
Nicely done!
Have you any idea what the small toggle switch on the PRS guitars is doing?
TIA simon
|Steve Ahola
.. Have you checked www.prsguitars.com ? They have a description of 4 different switching circuits they use. Let me know what you find out. On my home page, I'll be posting all of the interesting pickup wiring diagrams I can find or figure out.
.. The only decent book on wiring guitars that I am aware of is Donald Brosnac's "Guitar Electronics" published in 1980, which makes it almost 20 years out of date. I keep looking for a new edition that covers series/parallel wiring tricks used on PRS's, some of the newer Fender strats, and all of the other guitar companies that have gone beyond the LP/Tele/Strat circuits from the 50's.
Steve Ahola
|Page 1 of 1


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I'm about to type a set of words that not one person on the entire planet would have thought would be typed in this exact order in a single sentence.
Alright, here it is:
A man was saved from a bear attack by a Justin Bieber song.
There I said it, and I feel gross.
A man in Russia is crediting Bieber's song "Baby," in ringtone format, as his saving grace. Igor Vorozhbitsyn, a 42-year-old grandfather, told the Daily Mail he had just parked his car and was heading to his favorite fishing spot when the bear attacked him from behind.
"There was a tremendous impact on my back and the bear was on top of me."
After the bear scratched up his face, back, shoulders, and basically throttled the man, Vorozhbitsyn's cell phone went off, loudly filling the air with Bieber's dreamy tune. The bear then fled, and I'm assuming that's because of the sheer awfulness of the music.
Igor says that he is now, and will forever be, a Belieber. Congratulations Justin, you've just gained a 42-year-old, bear attack victim as a fan.
Clif Foster is an Entertainment Contributor for The Scoop. Follow him on Twitter at @CliftonFoster.


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The shivers
I have never written a letter to the Editor yet and I don't intend to make a production of this --I just feel a responsibility to comment on the suggestion from K. F., Port Jervis, New York, in the February, 1965 issue entitled "A Gripe," that, regarding newcomers, committees should be formed in charge of inducting, etc.: "All newcomers, prospects and members who are having trouble should be discussed in detail. Every time a sponsor fails, the whole committee should try to find out why and rectify it." I refuse to think of anything so awful! What about our Twelfth Tradition and anonymity?
Maybe I have a twisted mind, but with shivers I force myself to picture a meeting of a 'committee' to discuss 'in detail' why newcomers and old-timers have failed.-- M. F.
Los Angeles, California
This is a preview. To view the full article, use the link below to begin a free 7-day trial!
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[1] http://www.aagrapevine.org/../printmail/18488
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TOP SELECTION: Race 4, No. 2 RELIABLE TEAM - $2.50
Creeping up in the weights off the debut win here over this track/trip but to compensate that he is open to improvement off that effort where he was very game and there to be run down. Outside a few of these dropping in class (but query on well they're going) it's isn't a strong line-up and he can go on with it tonight.
NEXT BEST: Race 2, No. 4 GUNNAR - $3.60
Honest albeit no match for what looks a pretty smart one in Classic Unicorn over the 1000m at Sha Tin last start but they cleared out from the rest and the form has stacked up from that race with Super Junior who Gunnar had 2.5 lengths on, came out and won on Monday. Not a deep race overall and he may be able to take up the running.
VALUE: Race 8, No. 6 GREEN LUCK - $5.00
Suspect he'd be an outright favorite if Purton stuck, but he's with Fat Turtle who will need luck from an outside alley. This 4yo has a good strike rate over the 1650m at Happy Valley where he carried weight to win over this track/trip two starts ago before rising to this class when he was inconvenienced by the winner. Worth another chance.
BOLTER: Race 7, No. 3 HARRIER JET - $13.00
Doesn't have a great winning strike...


text:
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Published Document
Food Safety and Inspection Service, USDA.
Notice of public meeting and request for comments.
The Office of the Under Secretary for Food Safety, of the U.S. Department of Agriculture, and the Food and Drug Administration, of the Department of Health and Human Services, are sponsoring a public meeting on September 3, 2003, to review the agenda items and to receive comments on all issues coming before the Twenty-sixth Session of the Codex Committee on Fish and Fishery Products, which will be held in Alesund, Norway, October 13-17, 2003.
The public meeting is scheduled for Wednesday, September 3, 2003, from 9 am. to 12 noon.
The public meeting will be held in the Harvey Wiley Federal Building, 5100 Paint Branch Parkway, College Park, Maryland 20740. Building control will direct the participants to the meeting room.
To receive copies of the documents relevant to this notice, contact the Food Safety Inspection Service (FSIS) Docket Clerk, U.S. Department of Agriculture, Food Safety and Inspection Service, Room 102, Cotton Annex, 300 12th Street SW., Washington, DC 20250-3700. The documents will also become accessible via the World Wide Web at the following address: http://www.codexalimentarius.net. Send comments, in triplicate, to the FSIS Docket room and reference Docket # 03-023N. All comments submitted in response to this notice will be available for public inspection in the FSIS Docket room between 8:30 a.m. and 4:30 p.m., Monday through Friday.Start Further Info
Syed Amjad Ali, Senior Staff Officer, U.S. Codex Office, FSIS, Room 4861, South Agriculture Building, 1400 Independence Avenue SW., Washington, DC 20250-3700, telephone (202) 205-7760; Fax (202) 720-3157. Persons requiring a sign language interpreter or other special accommodations should notify Ms. Janet Walraven, at telephone (301) 436-2300; Fax; (301) 436-2601.End Further Info End Preamble Start Supplemental Information
The Codex Alimentarius Commission (Codex) was established in 1962 by two United Nations organizations, the Food and Agriculture Organization and the World Health Organization. Codex is the major international organization for encouraging fair international trade in food and protecting the health and economic interests of consumers. Through adoption of food standards, codes of practice and other guidelines developed by its committees, and by promoting their adoption and implementation by governments, Codex seeks to ensure that the world's food supply is sound, wholesome, free from adulteration, and correctly labeled.
The Codex Committee on Fish and Fishery Products was established to elaborate codes and standards for Fish and Fishery Products. The Government of Norway hosts this committee and will chair the committee meeting.
Issues To Be Discussed at the Public Meeting
The following specific issues will be discussed during the public meeting:
1. Matters referred by the Codex Alimentarius Commission and other Codex committees.
2. Proposed Draft Standard for Salted Atlantic Herring and Salted Sprats.
3. Proposed Draft Code of Practice for Fish and Fishery Products (sections 6 Aquaculture, 7 Molluscan Shellfish, 10 Processing of Quick Frozen Coated Fish Products, 11 Processing of Salted Fish, 12 Processing of Smoked Fish, 13 Processing of Lobsters and Crabs, 14 Processing of Shrimps and Prawns, 15 Processing of Cephalopods, 17 Transport, and 18 Retail).
4. Proposed Draft Standard for Live and Processed Molluscs.
5. Proposed Draft Model Certificate for Fish and Fishery Products "sanitary" certificate.
6. Proposed Draft Model Certificate for Fish and Fishery Products (other certificates).
7. Proposed Draft Standard for Smoked Fish.
8. Proposed Draft Amendment to the Standard for Quick Frozen Lobsters.
9. Proposed Draft Standard for Scallops Adductor Muscle Meat.
10. Proposed Draft Amendment to the Standard for Salted Fish and Dried Salted Fish of the Gadidae Family.
11. Proposed Draft Standard for Sturgeon Caviar.
12. Discussion paper—Inclusion of additional species and on labeling requirements related to the "name of the product" in Codex Standards (Proposed Draft Amendment to the Canned Sardines Standard).
13. Discussion paper on how to measure fish content in fish sticks.
Additional Public Notification
Public awareness of all segments of rulemaking and policy development is important. Consequently, in an effort to better ensure that minorities, women, and persons with disabilities are aware of this notice, FSIS will announce it and make copies of this Federal Register publication available through the FSIS Constituent Update. FSIS provides a weekly Constituent Update, which is communicated via Listserv, a free e-mail subscription service. In addition, the update is available on-line through the FSIS Web page located at http://www.fsis.usda.gov. The update is used to provide information regarding FSIS policies, procedures, regulations, Federal Register notices, FSIS public meetings, recalls, and any other types of information that could affect or would be of interest to our constituents/stakeholders. The constituent Listserv consists of industry, trade, and farm groups, consumer interest groups, allied health professionals, scientific professionals, and other individuals that have requested to be included. Through the Listserv and web page, FSIS is able to provide information to a much broader, more diverse audience.
For more information contact the Congressional and Public Affairs Office, at (202) 720-9113. To be added to the free e-mail subscription service Start Printed Page 41110(Listserv) go to the "Constituent Update" page on the FSIS web site at http://www.fsis.usda.gov/oa/update/update.htm. Click on "Subscribe to the Constituent Update Listserv" link, then fill out and submit the form.Start Signature
Done at Washington, DC on: July 7, 2003.
F. Edward Scarbrough,
U.S. Manager for Codex Alimentarius.
[FR Doc. 03-17469 Filed 7-9-03; 8:45 am]


text:
Autologous Adult Adipose-Derived Regenerative Cell Injection Into Chronic Partial-Thickness Rotator Cuff Tears
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT03752827
Recruitment Status : Recruiting
First Posted : November 26, 2018
Last Update Posted : August 7, 2019
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Rotator Cuff Tear Rotator Cuff Tendinitis
|Device: Adipose Derived Regenerative Cells Drug: Corticosteroid
|Not Applicable
This is a prospective, double-blinded, randomized, active-controlled, multi-site, pivotal safety and superior effectiveness study in patients with symptomatic partial-thickness rotator cuff tears comparing a single ADRC injection generated with the Transpose® RT system into the supraspinatus tendon and surrounding area to standard-of-care (SOC) corticosteroid injection into the subacromial bursa.
Up to 20 U.S. centers will be initiated to enroll in the study. 246 subjects assigned to two randomization arms will be enrolled: an adipose-derived regenerative cell (ADRC) injection arm (ADRC treatment arm) and the SOC corticosteroid injection arm (active control arm). All subjects will be randomly assigned to ADRC treatment or active control arms in a 2:1 ratio.
|Study Type :
|Interventional (Clinical Trial)
|Estimated Enrollment :
|246 participants
|Intervention Model:
|Parallel Assignment
|Triple (Participant, Investigator, Outcomes Assessor)
|Masking Description:
|It is a double-blinded trial in which the subject, post-procedural investigator and imaging core laboratory radiologists are blinded.
|Primary Purpose:
|Official Title:
|A Prospective, Double-Blinded, Multi-Center Pivotal Trial of Autologous Adult Adipose-Derived Regenerative Cell Injection Into Chronic Partial-Thickness Rotator Cuff Tears
|Actual Study Start Date :
|May 13, 2019
|Estimated Primary Completion Date :
|September 15, 2020
|Estimated Study Completion Date :
|November 1, 2020
Experimental: Adipose Derived Regenerative Cells
Adipose-derived regenerative cell injection into the area of the supraspinatus tendon tear
Device: Adipose Derived Regenerative Cells
Adipose-derived regenerative cells isolated with the Transpose Ultra system
Active Comparator: Corticosteroid
Subjects in the active control arm will receive a corticosteroid injection into the subacromial space using ultrasound (US) guidance.
Drug: Corticosteroid
Corticosteroid injection into subacrominal space
- Improvement in Pain: VAS [ Time Frame: 48 weeks ]≥ 14-millimeter (mm) improvement in Visual Analog Scale (VAS)
- Improvement or no worsening in supraspinatus strength [ Time Frame: 48 weeks ]
supraspinatus strength on the MRC Muscle Scale compared to baseline For supraspinatus strength on the MRC Muscle Scale compared to baseline
• For subjects with normal supraspinatus strength (MRC Muscle Scale = 5] at baseline: no worsening in supraspinatus strength on the MRC Muscle Scale compared to baseline
- Percentage of subjects who demonstrate ≥ 14 mm improvement in VAS [ Time Frame: 24 weeks ]Pain score compared to baseline at 24 weeks
- Percentage of subjects who demonstrate improvement or no worsening of supraspinatus strength on the MRC Muscle Scale [ Time Frame: 24 weeks ]Supraspinatus strength on the MRC Muscle Scale compared to baseline at 24 weeks
- Mean improvement in VAS - Pain score [ Time Frame: 48 weeks ]VAS pain score compared to baseline
- Mean improvement in WORC score [ Time Frame: 24 weeks ]WORC score compared to baseline
- Percentage of subjects who demonstrate an improvement in MRI-assessed supraspinatus tendon tear status [ Time Frame: 24 weeks ]Percentage of subjects with improvement
- Percentage of subjects who demonstrate a ≥ 1-grade improvement in supraspinatus strength on the MRC Muscle Scale [ Time Frame: 24 weeks ]Supraspinatus strength on the MRC Muscle Scale compared to baseline at 24 weeks.
- Mean improvement in Rand Short Form-36 score [ Time Frame: 48 weeks ]Rand Form-36 score compared at baseline
- Measurement of subject satisfaction with treatment on a VAS scale (VAS - Satisfaction) [ Time Frame: 48 weeks ]VAS satisfaction score improvement
- Measurement of EuroQoL-5D-5L (EQ-5D-5L) [ Time Frame: 24 weeks ]EuroQoL -5D-5L score
- Measurement of Shoulder Activity Level [ Time Frame: 24 weeks ]Recording shoulder activity level
- Measurement of shoulder motion (forward elevation, shoulder abduction in the plane of the scapula) [ Time Frame: 24 weeks ]As determined by goniometer
- MRI-assessed supraspinatus tendon tear location (articular surface, bursal surface, interstitial), tendon tear size and tendon tear percent thickness involvement [ Time Frame: 48 weeks ]tendon tear size and tendon thickness
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|40 Years to 75 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Males and females 40-75 years of age (inclusive).
- Subjects have a minimum of three (3) months of clinical symptoms consistent with a partial-thickness rotator cuff tear including but not limited to pain, muscle weakness, or limited active range of motion (AROM).
- Subjects have > 70% passive range of motion (PROM) of the index shoulder.
- Subjects have a baseline VAS - Pain score of ≥ 30 mm.
- Subjects have a partial-thickness rotator cuff tear, defined as ≥50% partial-thickness tear of the supraspinatus tendon on a 3 Tesla (3T) MRI within the last 3 months, as determined by the Investigator.
- Subjects can give appropriate consent.
Exclusion Criteria:
- Age < 40 or > 75.
- Subject has an insufficient amount of subcutaneous tissue to allow recovery of 100 milliliters (mL) of lipoaspirate.
- Subjects who have received a corticosteroid injection in the index rotator cuff site within the last 3 months.
- Subjects who have received more than one (1) previous corticosteroid injections in the index rotator cuff site at any point in the past.
- Subjects with severe arthrosis of the glenohumeral or acromioclavicular joint.
- Subjects with a full-thickness tear of the rotator cuff.
- Subjects with any previous shoulder surgery on the affected shoulder.
- Subjects with a previous or current history of adhesive capsulitis of the index shoulder.
- Subjects with current cervical radiculopathy impacting the index shoulder.
- Subjects who require the use of index arm for ambulation or mobilization via wheelchair, walker, crutches or cane.
- Subjects with any contraindication to MRI scan according to MRI guidelines, or who are unwilling to undergo MRI procedures.
- Subjects whose pain behavior or pain medication usage is, in the opinion of the Investigator, out of proportion to the underlying clinical condition or could interfere with the study-required assessments.
- Subjects with a history of systemic malignant neoplasms within the last 5 years.
- Subjects with biopsy-proven, malignant or local neoplasm within the last 6 months or any history of local neoplasm at the site of administration (on the affected arm).
- Subject is receiving immunosuppressant therapy or has a known immunologic or severe autoimmune disease that requires chronic immunosuppressive or immunomodulatory therapy (e.g., human immunodeficiency virus, systemic lupus erythematosus, rheumatoid arthritis, etc.).
- Subject is on an active regimen of chemotherapy or radiation-based treatment.
- Subjects with an allergy to sodium citrate or any "caine" type of local anesthetic.
- Subject is pregnant or breastfeeding or plans to become pregnant in the next 12 months.
- Subjects with clinically significant abnormal Lab tests (i.e. basic metabolic panel (BMP) or equivalent (e.g. CHEM-7), complete blood count (CBC), Liver function tests (LFTs), and prothrombin time/international normalized ratio (PT/INR)) as interpreted by the Investigator.
- Subjects with clinical evidence of an abdominal hernia or a history of abdominal mesh placement.
- Subjects with a history of a bleeding diathesis or coagulopathy
- Subject is, in the opinion of the Investigator, unable to comply with the requirements of the study protocol or is unsuitable for the study for any reason. Examples include the inability of the subject to complete patient-reported outcome instruments (PROs) and the inability of the Investigator to perform the injection procedure properly because of anatomic limitations of the subject.
- Subject is currently participating in another clinical trial that has not yet completed its primary endpoint. (Noninterventional observational studies are not exclusionary.)
- Subject is a litigant in a civil or criminal case or has an active workman's compensation case in progress.
- Subject is part of a vulnerable population who, in the judgment of the Investigator, is unable to give informed consent for reasons of incapacity, immaturity, adverse personal circumstances or lack of autonomy. This may include: individuals with a mental disability, persons in nursing homes, children, impoverished persons, persons in emergency situations, homeless persons, nomads, refugees, and those incapable of giving informed consent. Vulnerable populations also may include members of a group with a hierarchical structure such as university students, subordinate hospital and laboratory personnel, employees of the Sponsor, members of the armed forces, and persons kept in detention.
- Uncooperative subjects or those with neurological/psychiatric disorders who are incapable of following directions or who are predictably unwilling to return for follow-up examinations.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03752827
|Contact: Deborah Quigley
|Contact: Glenn Winnier, PhD
|713 440 9900
|United States, Florida
|Sports and Orthopedic Center
|Coral Springs, Florida, United States, 33067
|Contact: Danahe Navarrete email@example.com
|Principal Investigator:
|Jason Hurd, MD
|Sanford Orthopedics & Sports Medicine
|Responsible Party:
|InGeneron, Inc.
|ClinicalTrials.gov Identifier:
|NCT03752827 History of Changes
|Other Study ID Numbers:
|First Posted:
|November 26, 2018 Key Record Dates
|Last Update Posted:
|August 7, 2019
|Last Verified:
|August 2019
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
|Studies a U.S. FDA-regulated Drug Product:
|Studies a U.S. FDA-regulated Device Product:
|Device Product Not Approved or Cleared by U.S. FDA:
|Pediatric Postmarket Surveillance of a Device Product:
rotator cuff tear
adipose-derived regenerative cells
adipose-derived stem cells
partial rotator cuff tears
Rotator Cuff Injuries
Wounds and Injuries
Shoulder Injuries
Tendon Injuries
Muscular Diseases
Musculoskeletal Diseases


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How do I place my order?
Our website has all products and services simply call us on 01934 522490
Will I get an invoice?
Yes. A soft copy will be made available to you.
How will I know if the item ordered will fit in the place I want?
In most cases, the dimensions of the listed item will be displayed, so you can confirm the fit prior to ordering. In case the same is not displayed, you may contact us on 01934 522490 and we will try and get you the dimensions prior to your ordering.
Can I change the item after placing the order for it?
Yes you can but the same must be done well in advance. In such case, the differential amount must either be paid by you or in case of refund, will be refunded by us, prior to the delivery. The new delivery schedule may vary depending on the item and model ordered.
Do I need to make any special arrangements prior to delivery?
It is recommended that the spot where the appliance(s) is to be placed and installed is kept clear and ready for it to be installed. Based on the dimensions, especially larger items, it is advisable to ensure that the access from your doorstep to the place where it is to be installed is kept clear. On the day of delivery, kindly keep the driveway clear for our delivery van to park and unload.
How will I know when the item will be delivered to my residence?
Once the your order is ready for dispatch, you will be contacted by email and/or phone on the expected delivery date and time.
Can I request an alternate delivery date?
Yes, but the same must be intimated at least 48 hours prior to delivery.
What if you are unable to deliver on the appointed date?
It is possible that for reasons beyond our control, for instance inclement weather or unforeseen traffic blockage, we shall inform you and request an alternate date.
Can I change my delivery address?
Yes you can but the same must be informed to us at least 48 hours prior to the delivery date.
Is the delivery free of cost or will I be charged?
The delivery is free unless same day delivery is required (and available)
What postcodes do you deliver to
We deliver to our local area of North Somerset and some surrounding towns/villages and Near Bristol in the following postcode regions.
Do you charge for installation?
Yes. The charges depend on the appliance(s) ordered and whether you have paid for the same during the ordering process.
Will your engineers disconnect my earlier appliance prior to installing the new one?
Yes. Our engineers can disconnect your old appliance if paid for during the ordering process.
In case any masonry changes have to be made for installation of the new appliance, will your engineers do it?
No. Any masonry or carpentry works needs to be arranged by you and completed prior to installation by our engineers.
The refitting of integrated appliance door fronts which is included when installation is paid for is excluded.
Gas Appliances
You will also have to ensure that the Hot Zone i.e. the area between the Hob or cooker and above it, must be clear of any inflammable materials like wallpaper, wood panel etc.
Do your engineers bring along connecting cables and hoses?
Yes. Our engineers bring along the necessary connecting cables and hoses but only if the installation has been paid for during the ordering process.
I didn't pay for installation while placing the order, can I pay for it later?
Yes just give a call on 01934 522490 to arrange this.
Who carries out any in warranty repairs with an appliance I have purchased from you?
All warranty repairs are performed by the manufacturer or one of its appointed agents according to their term and conditions.
All appliances have to be registered with the manufacturer as specified in the documentation you will receive with your purchase,
this is your responsibility and we can not be held responsible for any failure of a warranty due to this not being carried out or non
compliance with the manufacturers terms and conditions.
The appliances we sell are designed for a domestic environment not a commercial one.
All the appliances we supply are new and will come with a minimum 1 year manufacturer warranty.
This does not affect your statutory rights.
Can you arrange an in warranty appointment?
While we cannot arrange the appointment for you we can advise you on contact details or things to check before booking a service call.
How do I know what items are repaired by you?
Our website details all brands and appliances that we repair. In case you have a brand or appliance not listed on our site, call us and we will try and fix it.
What are the repair charges?
That will depend on what needs repairing and what component(s) requires replacement.
The same can be estimated only after our engineer inspects the appliance to be repaired.
Do you repair the appliance in my location or does it have to be moved to your workshop?
Our engineer will take a call on that after inspection. We will always try and repair the same at your location, however, if the appliance needs to be taken to our workshop, then extra charges may apply (this however is very rare)
Where we supply and fit a spare part there is a 90 day guarantee against failure due to faulty manufacturing or defect of those parts inc vat and labour costs. There is no warranty where we have not supplied the spare part(s) in any event. For example where you the customer have provided the spare part and we have fitted it.
A repair to an appliance which involved the removing of foreign objects from the appliance which was causing a fault carries no warranty.
In case you have further questions, please do not hesitate to call us between 8AM – 5PM, Mon-Thurs & 8AM – 4.30PM Fri on 01934 522490.
You can also email us using the contact form at the foot of the website.


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The Secret to Securing an FHA Loan With a Non-Occupying Co. – Reasons to Use a Non-Occupying Co-Borrower. The most common reason borrowers use a non-occupying co-borrower on an FHA loan is lack of funds. If you don't have enough income to qualify for the loan on your own, you can use the income of a loved one to quality. Again, this person must have their own residence established.
FHA Guidelines Regarding Non-Occupant Co-Borrowers – FHA loans do allow the use of non-occupant co-borrowers, but they have strict rules you must follow. The Non-Occupant Co-Borrower Guidelines. First, at least one borrower must occupy the property full-time. fha loans are only for owner-occupied properties.
FHA Loan Requirements for 2017 – In addition to borrower qualifications, the property itself must meet certain requirements before you can qualify for an FHA mortgage. Investment properties are not eligible The property can't be a.
How Much Home Can I Qualify For Fha 9 minute read. There are a lot of potential first-time home buyers that delay getting a mortgage simply because it seems like a long and daunting process. There are new mortgage programs available in 2018 that make it easier for first-time home buyers to qualify for a loan then ever before.Applying For A Fha Loan With Bad Credit bad credit loan applying fha – Tom-collins-yachts – The term "bad credit home loans" often refers to an FHA mortgage, or sub-prime loan. Check current fha rates. 2018 fha credit requirements. Because FHA home loans are insured they are much less risky for lenders. Minimum Credit Scores for FHA Loans – FHA.com – minimum credit score requirements for FHA home loans depend on which FHA. a year.
Find out which mortgage is right for you: Comparing conventional, FHA and VA loans – The FHA allows borrowers to spend up to 57 percent of their income on monthly debt obligations, such as mortgage, credit cards, student loans and car loans. In contrast, conventional mortgage.
FHA Loan Eligibility Requirements for 2019 – Home.Loans – FHA-approved banks and lenders are not required to set credit score minimums for potential borrowers. As a matter of fact, the guidelines set by the FHA are just that: guidelines. lenders are encouraged to set their own requirements (within reason) as well as a limit to the amount of FHA.
A relative, charity, your employer or workers' union, even a friend can gift you the funds for your down payment as long as the friend has invested interest in the borrower. This is a way that an FHA loan can provide the borrower 100% financing with no down payment out of pocket.
Borrowers of Federal Housing Administration loans must provide proof of income. The FHA insures loans that private lenders finance, guaranteeing reimbursement for their losses if borrowers default..
Minimum Fico For Mortgage See how else your credit score affects your mortgage rate.. The government doesn't have a minimum credit score requirement to qualify for VA loans, though many lenders require a minimum score.
New-FHA-Guidelines-2019 – fha-world.com – New FHA Guidelines 2019. Borrowers with a prior bankruptcy, foreclosure, deed-in-lieu, or short sale may be eligible for an FHA insured loan if the bankruptcy, foreclosure, deed-in-lieu, short sale was the result of a documented extenuating circumstance.
Non-QM, Document Products; News From FHA, VA, HFAs; Compass and API – Nations Direct Mortgage will light the way with its new proprietary Non-QM Direct programs: credit direct for Full Doc borrowers outside. experience working with FHA, VA, USDA, GSE and/or MI claims.
This FHA mortgage can help you buy and repair a home – especially the payment schedule and requirements. When the renovations are completed, the mortgage borrower is required to.


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You are not permitted to download, save or email this image. Visit image gallery to purchase the image.
The proposal from New Zealand's largest insurer comes as it also plans to introduce risk-based pricing, which could mean customers who live in areas prone to natural disasters and severe weather pay more for home insurance, in a progressive roll-out from July 1.
Seven branches, including South Dunedin and Alexandra, may close, which would reduce AMI's network to 51.
Seven staff across the two branches would be affected by the proposal.
Central Otago deputy mayor Neil Gillespie said he hoped any decision AMI made considered those people who would be adversely affected.
''This is becoming an unfortunate and unwelcome trend in small-town New Zealand,'' he said.
''I understand the business sense.
''But Central Otago, for example, is isolated and has a high population of elderly who rely on those branches. I hope AMI think about those things because that, too, could affect their business.''
Alex Geale, executive general manager of AMI's retail network, said it was reviewing its network as a result of customer preferences changing.
''We are increasingly finding that our customers across New Zealand are preferring to contact AMI through other means, rather than visiting their local stores.''
Ms Geale confirmed the insurer had ''tens of thousands'' of customers in Otago and Southland.
Branches are located in Dunedin, Gore, Invercargill, Mosgiel, Oamaru and Queenstown in addition to those in Alexandra and South Dunedin, which were ''under review''.
Ms Geale confirmed an 18% increase in customers using messaging apps such as Facebook messenger, WhatsApp, WeChat and AMI's artificial intelligence-powered ''chatbot'' Amy over the past 12 months, which had become the ''customer service norm''.
AMI had also noted a 35% increase over the past year in customers using the online payment system.
''While it is disappointing that we might have to close a small number of stores, AMI will continue to be there for New Zealanders, whether they live in urban areas or smaller communities, by providing service in the way they want it to be - conveniently, efficiently and effectively.''


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Soul Sprout
Growing in a Bold New Direction
Two Moms in the Raw rebrands as Soul Sprout
Suffering from rapidly declining sales, "Two Moms in the Raw" was a pioneer/first mover brand faced with increasing pressure from second generation category brands and FDA regulation. New investors green lighted an entire new positioning around Sprouted Ingredients, impacting the entire brand expression.
Consumer research data informed our audience title "Wellness Warrior" — a dedicated, educated, and mindful person, who's exceptionally committed to their own personal standard of health & wellness. Connecting the brand name, SOI and language around the brand idea ("Charged for Life") became priority number one. With these key points in mind, an incredibly tribal, creative, and holistic expression was born.
project scope
• Brand vision
• Identity Refresh
• Packaging
• Brand extension
• Brand guidelines


text: In this fourth instalment of the series we will look at our first applications of the ISAC cube and the simple motherboard, which will give a good introduction to the possibilities of the device. Complete example programs developed for these applications, along with extra information, are available for download from the Elektor Electronics website.Before we present the individual example applications, a few initial remarks are in order regarding the example programs and their use.– The applications and demonstration programs are written in C51 code in such a way that (with one exception) they can be used with the restricted version of µVision2 (maximum code size of 2 Kbytes, no floating-point arithmetic). For larger application programs the full version of µVision2, or another 8051 tool, must be resorted to.


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A month has gone by since the last earnings report for Intercept Pharmaceuticals (ICPT - Free Report) . Shares have added about 12.2% in that time frame, outperforming the S&P 500.
Will the recent positive trend continue leading up to its next earnings release, or is Intercept due for a pullback? Before we dive into how investors and analysts have reacted as of late, let's take a quick look at the most recent earnings report in order to get a better handle on the important catalysts.
Intercept Beats on Q4 Revenues, NASH Study in Focus
Intercept incurred a loss of $2.97 per share in the fourth quarter, wider than the Zacks Consensus Estimate of a loss of $2.42 but narrower than the year-ago loss of $4.43.
Quarterly revenues were $53.3 million, up from $37.7 million in the year-ago quarter. Revenues also surpassed the Zacks Consensus Estimate of $51.7 million.
Quarter in Detail
Ocaliva recorded $52.9 million of sales, up from $46.6 million recorded in the third quarter of 2018 and $37.3 million in the year-earlier period. Net sales in the United States came in at $41.1 million while the ex-U.S. Ocaliva net sales summed $11.8 million.
Ocaliva in combination with ursodeoxycholic (UDCA) was approved in the United States during 2016 for the treatment of primary biliary cholangitis ("PBC") in adults with an inadequate response to UDCA or as monotherapy in adults, who are unable to endure UDCA. The drug was also granted a conditional approval by the European Commission. In February 2018, Ocaliva's label was updated in the United States to include a boxed warning and a dosing table that reinforced the existing dosing schedule in PBC patients with Child-Pugh Class B or C or decompensated cirrhosis.
Research and development expenses increased 10.1% year over year to $63.3 million, primarily driven by more clinical development programs for Ocaliva. However, selling, general and administrative expenses decreased 15.8% to $71 million.
2019 Outlook
Ocaliva's net sales are expected between $225 million and $240 million in 2019. Intercept continues to expect operating expenses to be $450-$470 million in 2019.
Pipeline Update
Obeticholic acid (OCA) is also being evaluated for other indications including non-alcoholic steatohepatitis ("NASH") and primary sclerosing cholangitis ("PSC").
Earlier in 2019, Intercept announced positive top-line results from its pivotal phase III REGENERATE study of OCA on patients with liver fibrosis due to NASH. The company stated that the primary endpoint of the study — fibrosis improvement without worsening of NASH at 18 months — was achieved with the 25 mg daily dose of OCA.
Also, a numerically greater proportion of patients in both OCA treatment arms (taking doses of 10 mg and 25 mg) met the primary endpoint of NASH resolution with no deterioration of liver fibrosis as compared to placebo.
However, this did not reach statistical significance. Nevertheless, the study was required to attain one of the two primary goals per the FDA which it did.
Intercept plans to file for an approval of OCA as a NASH treatment both in the United States and in Europe during the second half of 2019. The company will also release data from the REGENERATE analysis at the European Association for the Study of the Liver (EASL) conference in April.
The REVERSE study is designed to evaluate the efficacy and safety of Ocaliva on NASH patients suffering compensated cirrhosis. The probe is currently enrolling patients, which is expected to be complete by the end of 2019.
How Have Estimates Been Moving Since Then?
In the past month, investors have witnessed a downward trend in fresh estimates. The consensus estimate has shifted -11.69% due to these changes.
VGM Scores
At this time, Intercept has a nice Growth Score of B, though it is lagging a lot on the Momentum Score front with a D. Charting a somewhat similar path, the stock was allocated a grade of F on the value side, putting it in the bottom 20% quintile for this investment strategy.
Overall, the stock has an aggregate VGM Score of D. If you aren't focused on one strategy, this score is the one you should be interested in.
Estimates have been broadly trending downward for the stock, and the magnitude of these revisions indicates a downward shift. Notably, Intercept has a Zacks Rank #3 (Hold). We expect an in-line return from the stock in the next few months.