text:
Hepatitis E
|Hepatitis E
|Hepatitis E virus
Infectious disease
|Nausea, jaundice[1]
|Diagnostic method
|Blood test[1]
|Rest, Ribavirin(if chronic)[1]
|28 million (2013)[2]
Hepatitis E is inflammation of the liver caused by infection with the hepatitis E virus.[3] It is one of five known human hepatitis viruses: A, B, C, D, and E. HEV is a positive-sense, single-stranded, nonenveloped, RNA icosahedral virus; HEV has a fecal-oral transmission route.[4][5] Infection with this virus was first documented in 1955 during an outbreak in New Delhi, India.[6] A preventive vaccine (HEV 239) is approved for use in China.[7]
Although hepatitis E often causes an acute and self-limiting infection (the viral infection is temporary and the individual recovers) with low death rates in the western world, it bears a high risk of developing chronic hepatitis in people with a weakened immune system with substantially higher death rates. Organ transplant recipients who receive medications to weaken the immune system and prevent organ rejection are thought to be the main population at risk for chronic hepatitis E.[8] Furthermore, in healthy individuals during the duration of the infection, the disease severely impairs a person's ability to work, care for family members, and perform other daily activities. Hepatitis E occasionally develops into an acute, severe liver disease, and is fatal in about 2% of all cases.
Clinically, it is comparable to hepatitis A, but in pregnant women, the disease is more often severe and is associated with a clinical syndrome called fulminant liver failure. Pregnant women, especially those in the third trimester, have a higher rate of death from the disease of around 20%.[9]
Hepatitis E newly infected about 28 million people in 2013.[2]
Signs and symptoms
Acute infection
The incubation period of hepatitis E varies from 3 to 8 weeks. After a short prodromal phase symptoms lasting from days to weeks follow. They may include jaundice, fatigue, and nausea. The symptomatic phase coincides with elevated hepatic aminotransferase levels.[10]
Viral RNA becomes detectable in stool and blood serum during incubation period. Serum IgM and IgG antibodies against HEV appear just before onset of clinical symptoms. Recovery leads to virus clearance from the blood, while the virus may persist in stool for much longer. Recovery is also marked by disappearance of IgM antibodies and increase of levels of IgG antibodies.[5][10]
Chronic infection
While usually an acute disease, in immunocompromised subjects—particularly in solid organ transplant patients—hepatitis E may cause a chronic infection.[11] Occasionally this may cause liver fibrosis and cirrhosis.[12]
Other organs
Infection with hepatitis E virus can also lead to problems in other organs. For some of these reported conditions the relationship is tenuous, but for several neurological and blood conditions the relationship appears causal:[13]
- Acute pancreatitis
- Guillain-Barré syndrome (acute limb weakness due to nerve involvement) and neuralgic amyotrophy (arm and shoulder weakness)
- Hemolytic anemia in people with the hereditary risk factor glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
- Glomerulonephritis with nephrotic syndrome and/or cryoglobulinemia
- Mixed cryoglobulinemia, where antibodies in the bloodstream react inappropriately at low temperatures
- Severe thrombocytopenia (low platelet count in the blood) which confers a risk of dangerous bleeding
Infection in pregnancy
Pregnant women show a more severe course of infection than other populations. Mortality rates of 20% to 25% and hepatic failure have been reported from outbreaks of genotype 1 HEV in developing countries. Besides signs of an acute infections, adverse maternal and fetal outcomes may include preterm delivery, abortion, stillbirth, and intrauterine fetal and neonatal death.[14][15] Reports about infection of pregnant women with genotype 3 HEV in industrialized countries do exist, but do not report comparable severe outcomes.
The pathologic and biologic mechanisms behind the adverse outcomes of pregnancy infections remain largely unclear so far. Mainly, increased viral replication and influence of hormonal changes on the immune system have been discussed lately.[16] Furthermore, studies showing evidence for viral replication in the placenta[17] or reporting the full viral life cycle in placental-derived cells in vitro implicate the human placenta as site of extra-hepatic replication.
Only one serotype of the virus is known, and classification is based on the nucleotide sequences of the genome.[18] Genotype 1 has been classified into five subtypes, genotype 2 into two subtypes, and genotypes 3 and 4 have been into 10 and seven subtypes, respectively.Differences have been noted between the different genotypes. For genotype 1, the age at which incidence peaks is between 15 and 35 years and mortality is about 1%. Genotypes 3 and 4—the most common in Japan—are more common in people older than 60 years and the mortality is between 5 and 10%.
- Genotype 1 has been isolated from tropical and several subtropical countries in Asia and Africa.[19]
- Genotype 2 has been isolated from Mexico, Nigeria, and Chad.[20]
- Genotype 3 has been isolated almost worldwide including Asia, Europe, Oceania, and North and South America.[21]
- Genotype 4 appears to be limited.[19]
Genotypes 1 and 2 are restricted to humans and often associated with large outbreaks and epidemics in developing countries with poor sanitation conditions.[19] Genotypes 3 and 4 infect humans, pigs, and other animal species and have been responsible for sporadic cases of hepatitis E in both developing and industrialized countries.[22]
In the United Kingdom, the Department for Environment, Food and Rural Affairs said that the number of human hepatitis E cases increased by 39% between 2011 and 2012.[23]
Hepatitis E is widespread in Southeast Asia, northern and central Africa, India, and Central America.[24] It is spread mainly by the fecal-oral route due to fecal contamination of water supplies or food; person-to-person transmission is uncommon.[25]
The incubation period following exposure to the hepatitis E virus ranges from 3 to 8 weeks, with a mean of 40 days.[25] Outbreaks of epidemic hepatitis E most commonly occur after heavy rainfalls and monsoons because of their disruption of water supplies.[26] Major outbreaks have occurred in New Delhi, India (30,000 cases in 1955–1956),[27] Burma (20,000 cases in 1976–1977),[28] Kashmir, India (52,000 cases in 1978),[29] Kanpur, India (79,000 cases in 1991),[27] and China (100,000 cases between 1986 and 1988).[30]
DEFRA said that evidence indicated the increase in hepatitis E in the UK was due to food-borne zoonoses, citing a study that found 10% of pork sausages on sale in the UK contained the virus. Some research suggests that food must reach a temperature of 70 °C for 20 minutes to eliminate the risk of infection. An investigation by the Animal Health and Veterinary Laboratories Agency found hepatitis E in 49% of pigs in Scotland.[23]
Hepatitis E infection appeared to be more common in people on hemodialysis, although specific risk factors for transmission is not clear.[31]
Animal reservoir
The disease is thought to be a zoonosis in that animals are thought to be the source. Both deer and swine have been implicated.[32] Domestic animals have been reported as a reservoir for the hepatitis E virus, with some surveys showing infection rates exceeding 95% among domestic pigs.[33] Replicative virus has been found in the small intestine, lymph nodes, colon, and liver of experimentally infected pigs. Transmission after consumption of wild boar meat and uncooked deer meat has been reported, as well.[34] The rate of transmission to humans by this route and the public health importance of this are, however, still unclear.[35]
A number of other small mammals have been identified as potential reservoirs: the lesser bandicoot rat (Bandicota bengalensis), the black rat (Rattus rattus brunneusculus) and the Asian house shrew (Suncus murinus). A new virus designated rat hepatitis E virus has been isolated.[36]
A rabbit hepatitis E virus has been described,[37] with a study published in 2014 showing that research rabbits from two different American vendors showed seroprevalences of 40% for supplier A and 50% for supplier B when testing for antibodies against hepatitis E virus (HEV). Supplier A was a conventional rabbit farm, and supplier B was a commercial vendor of specific pathogen-free research rabbits. The study remarks, "HEV probably is widespread in research rabbits, but effects on research remain unknown." Laboratory animal care personnel, researchers, and support staff represent a new population at risk for HEV infection, and research facilities should be diligent in measures to prevention of this possibly zoonotic pathogen.[38]
An avian virus has been described that is associated with hepatitis-splenomegaly syndrome in chickens. This virus is genetically and antigenically related to mammalian HEV, and probably represents a new genus in the family.[39]
The virus has since been classified into the genus Orthohepevirus, and has been reassigned into the Hepeviridae family. The virus itself is a small nonenveloped particle.The genome is about 7200 bases in length, is a polyadenylated, single-strand RNA molecule that contains three discontinuous and partially overlapping open reading frames (ORFs) along with 5' and 3' cis-acting elements, which have important roles in HEV replication and transcription. ORF1 encodes a methyltransferase, protease, helicase and replicase; ORF2 encodes the capsid protein and ORF3 encodes a protein of undefined function. A three-dimensional, atomic-resolution structure of the capsid protein in the context of a virus-like particle has been described.[40][41]
As of 2009, around 1,600 sequences of both human and animal isolates of HEV are available in open-access sequence databases. Species of this genus infect humans, pigs, boars, deer, rats, rabbits, and birds.[42]
Virus lifecycle
The lifecycle of hepatitis E virus is unknown; the capsid protein obtains viral entry by binding to a cellular receptor. ORF2 (c-terminal) moderates viral entry by binding to HSC70.
Geldanamycin blocks the transport of HEV239 capsid protein, but not the binding/entry of the truncated capsid protein, which indicates that HSP90 plays an important part in HEV transport.[40]
Sanitation is the most important measure in prevention of hepatitis E; this consists of proper treatment and disposal of human waste, higher standards for public water supplies, improved personal hygiene procedures, and sanitary food preparation. Thus, prevention strategies of this disease are similar to those of many others that plague developing nations.[25]
A vaccine based on recombinant viral proteins was developed in the 1990s and tested in a high-risk population (in Nepal) in 2001.[43] The vaccine appeared to be effective and safe, but development was stopped for lack of profitability, since hepatitis E is rare in developed countries.[44] No hepatitis E vaccine is licensed for use in the United States.[45]
Although other HEV vaccine trials have been successful, these vaccines have not yet been produced or made available to susceptible populations. The exception is China; after more than a year of scrutiny and inspection by China's State Food and Drug Administration (SFDA), a hepatitis E vaccine developed by Chinese scientists was available at the end of 2012. The vaccine—called HEV 239 by its developer Xiamen Innovax Biotech—was approved for prevention of hepatitis E in 2012 by the Chinese Ministry of Science and Technology, following a controlled trial on 100,000+ people from Jiangsu Province where none of those vaccinated became infected during a 12-month period, compared to 15 in the group given placebo.[46] The first vaccine batches came out of Innovax' factory in late October 2012, to be sold to Chinese distributors.[44]
Due to the lack of evidence, WHO as of 2015 did not make a recommendation regarding routine use of the HEV 239 vaccine.[47] National authorities may however, decide to use the vaccine based on the local epidemiology.[47]
In terms of treatment, ribavirin is not registered for hepatitis E treatment, though off-label experience for treating chronic hepatitis E with this compound exists. The use of low doses of ribavirin over a three-month period has been associated with viral clearance in about two-thirds of chronic cases. Other possible treatments include pegylated interferon or a combination of ribavirin and pegylated interferon. In general, chronic HEV infection is associated with immunosuppressive therapies, but remarkably little is known about how different immunosuppressants affect HEV infection. In individuals with solid-organ transplantation, viral clearance can be achieved by temporal reduction of the level of immunosuppression.[48][49]
The hepatitis E virus causes around 20 million infections a year. These result in around three million acute illnesses and as of 2010, 57,000 deaths annually.[50] It is particularly dangerous for pregnant women, who can develop an acute form of the disease that is lethal in 30% of cases or more. HEV is a major cause of illness and of death in the developing world and disproportionate cause of deaths among pregnant women. Hepatitis E is endemic in Central Asia, while Central America and the Middle East have reported outbreaks.[51] Increasingly, hepatitis E is being seen in developed nations, with reports in 2005 of 329 cases of hepatitis E virus infection in England and Wales.[52]
Recent outbreaks
In 2004, two outbreaks occurred, both of them in sub-Saharan Africa. An outbreak in Chad had several cases with fatalities.[53] The second was in Sudan also with several fatalities.[54] In October 2007, an epidemic of hepatitis E was suspected in Kitgum District of northern Uganda where no previous epidemics had been documented. This outbreak progressed to become one of the largest hepatitis E outbreaks in the world. By June 2009, the epidemic had caused illness in 10,196 persons and 160 deaths.[55] In 2011, a minor outbreak was reported in Tangail, a neighborhood of Dhaka, Bangladesh.[56]
In July 2012, an outbreak was reported in South Sudanese refugee camps in Maban County near the Sudan border. South Sudan's Ministry of Health reported over 400 cases and 16 fatalities as of September 13, 2012.[57] Progressing further, as of February 2, 2013, 88 died due to the outbreak. The medical charity Medecins Sans Frontieres said it treated almost 4,000 patients.[58]
In April 2014, an outbreak in the Biratnagar Municipality of Nepal resulted in infection of over 6,000 locals and at least 9 dead.[59]
An outbreak was reported in Namibia in January 2018. Two mothers are dead and the total infected is reported as 490.[60]
The most recent common ancestor of hepatitis E evolved between 536 and 1344 years ago.[42] It diverged into two clades — an anthropotropic form and an enzootic form — which subsequently evolved into genotypes 1 and 2 and genotypes 3 and 4, respectively. The divergence dates for the various genotypes are as follows: Genotypes 1/2 367–656 years ago; Genotypes 3/4 417–679 years ago. For the most recent common ancestor of the various viruses themselves: Genotype 1 between 87 and 199 years ago; Genotype 3 between 265 and 342 years ago; and Genotype 4 between 131 and 266 years ago. The anthropotropic strains (genotype 1 and 2) have evolved more recently than the others, suggesting that this virus was originally a zooenosis. A study of genotype 3 has suggested that it evolved 320 years ago (95% HPD: 420 – 236 years ago) and that two main subtypes occur.[61]
The use of an avian strain confirmed the proposed topology of the genotypes 1–4 and suggested that the genus may have evolved 1.36 million years ago (range 0.23 million years ago to 2.6 million years ago).[42]
Genotypes 1, 3, and 4 all increased their effective population sizes in the 20th century.[42] The population size of genotype 1 increased noticeably in the last 30–35 years. Genotypes 3 and 4 population sizes began to increase in the late 19th century up to 1940–1945. Genotype 3 underwent a subsequent increase in population size until the 1960s. Since 1990, both genotypes' population sizes have been reduced back to levels last seen in the 19th century. The overall mutation rate for the genome has been estimated at roughly 1.4×10−3 substitutions/site/year.[42]
See also
This article incorporates public domain text from the CDC as cited
- 1 2 3 "Hepatitis E | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved 24 June 2018.
- 1 2 Global Burden of Disease Study 2013, Collaborators (22 August 2015). "Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013". Lancet. 386 (9995): 743–800. doi:10.1016/s0140-6736(15)60692-4. PMC 4561509
- ↑ "Hepatitis E". www.niaid.nih.gov. Retrieved 2016-02-23.
- ↑ "WHO | What is hepatitis?". www.who.int. Retrieved 2016-02-26.
- 1 2 "Hepatitis E". World Health Organization. Retrieved 2016-02-26.
- ↑ Subrat, Kumar (2013). "Hepatitis E virus: the current scenario". International Journal of Infectious Diseases. 17 (4): e228–e233. doi:10.1016/j.ijid.2012.11.026. Retrieved 27 February 2016.
- ↑ Li, Shao-Wei; Zhao, Qinjian; Wu, Ting; Chen, Shu; Zhang, Jun; Xia, Ning-Shao (2015-02-25). "The development of a recombinant hepatitis E vaccine HEV 239". Human Vaccines & Immunotherapeutics. 11 (4): 908–914. doi:10.1080/21645515.2015.1008870. ISSN 2164-5515. PMC 4514148
- ↑ Zhou X, de Man RA, de Knegt RJ, Metselaar HJ, Peppelenbosch MP, Pan Q.; De Man; De Knegt; Metselaar; Peppelenbosch; Pan (2013). "Epidemiology and management of chronic hepatitis E infection in solid organ transplantation: a comprehensive literature review". Rev Med Virol. 23 (5): 295–304. doi:10.1002/rmv.1751. PMID 23813631.
- ↑ WHO. "Global Alert and Response (GAR); Hepatitis E". Retrieved 26 January 2012.
- 1 2 Hoofnagle, J. H.; Nelson, K. E.; Purcell, R. H. (2012). "Hepatitis E". New England Journal of Medicine. 367 (13): 1237–1244. doi:10.1056/NEJMra1204512. PMID 23013075. (Subscription required (help)).
- ↑ Bonnet, D.; Kamar, N.; Izopet, J.; Alric, L. (2012). "L'hépatite virale E : Une maladie émergente". La Revue de Médecine Interne. 33 (6): 328–334. doi:10.1016/j.revmed.2012.01.017. PMID 22405325.
- ↑ Behrendt, Patrick; Steinmann, Eike; Manns, Michael P.; Wedemeyer, Heiner (2014-12-01). "The impact of hepatitis E in the liver transplant setting". Journal of Hepatology. 61 (6): 1418–1429. doi:10.1016/j.jhep.2014.08.047.
- ↑ Bazerbachi, F; Haffar, S; Garg, SK; Lake, JR (February 2016). "Extra-hepatic manifestations associated with hepatitis E virus infection: a comprehensive review of the literature". Gastroenterology report. 4 (1): 1–15. doi:10.1093/gastro/gov042. PMC 4760069
- ↑ Kumar A., Beniwal M., Kar P., Sharma J.B., Murthy N.S. (2004). "Wiley Online Library". International Journal of Gynecology & Obstetrics. 85 (3): 240–244. doi:10.1016/j.ijgo.2003.11.018.
- ↑ Patra, Sharda; Kumar, Ashish; Trivedi, Shubha Sagar; Puri, Manju; Sarin, Shiv Kumar (2007-07-03). "Maternal and Fetal Outcomes in Pregnant Women with Acute Hepatitis E Virus Infection". Annals of Internal Medicine. 147 (1): 28. doi:10.7326/0003-4819-147-1-200707030-00005. ISSN 0003-4819.
- ↑ Pérez-Gracia, María Teresa; Suay-García, Beatriz; Mateos-Lindemann, María Luisa (2017-05-01). "Hepatitis E and pregnancy: current state". Reviews in Medical Virology. 27 (3): n/a–n/a. doi:10.1002/rmv.1929. ISSN 1099-1654.
- ↑ Bose, Purabi Deka; Das, Bhudev Chandra; Hazam, Rajib Kishore; Kumar, Ashok; Medhi, Subhash; Kar, Premashis (2014). "Evidence of extrahepatic replication of hepatitis E virus in human placenta". Journal of General Virology. 95 (6): 1266–1271. doi:10.1099/vir.0.063602-0.
- ↑ Pérez-Gracia, María Teresa; García, Mario; Suay, Beatriz; Mateos-Lindemann, María Luisa (2015-06-28). "Current Knowledge on Hepatitis E". Journal of Clinical and Translational Hepatology. 3 (2): 117–126. doi:10.14218/JCTH.2015.00009. ISSN 2225-0719. PMC 4548356
- 1 2 3 Song, Yoon-Jae (2010-11-01). "Studies of hepatitis E virus genotypes". The Indian Journal of Medical Research. 132 (5): 487–488. ISSN 0971-5916. PMC 3028963
- ↑ Pelosi, E; Clarke, I (2008-11-07). "Hepatitis E: a complex and global disease". Emerging Health Threats Journal. 1: e8. doi:10.3134/ehtj.08.008. ISSN 1752-8550. PMC 3167588
- ↑ Hepatitis!E!Vaccine!Working!Group (2012). "Hepatitis(E:(epidemiology(and(disease(burden" (PDF). WHO. Retrieved 27 February 2016.
- ↑ Meng, X. J. (2010-01-27). "Hepatitis E virus: Animal Reservoirs and Zoonotic Risk". Veterinary microbiology. 140 (3–4): 256–65. doi:10.1016/j.vetmic.2009.03.017. ISSN 0378-1135. PMC 2814965
- 1 2 Doward, Jamie (21 September 2013). "Chefs fight for the right to serve their pork pink". The Observer newspaper. Retrieved 22 September 2013.
- ↑ Liu, Dongyou (2010-11-23). Molecular Detection of Human Viral Pathogens. CRC Press. p. 102. ISBN 9781439812372.
- 1 2 3 "Hepatitis E Fact sheet".
- ↑ Griffiths, Jeffrey; Maguire, James H.; Heggenhougen, Kristian; Quah, Stella R. (2010-03-09). Public Health and Infectious Diseases. Elsevier. ISBN 9780123815071.Google books has no page
- 1 2 Bitton, Gabriel (2005-05-27). Wastewater Microbiology. John Wiley & Sons. p. 132. ISBN 9780471717911.
- ↑ Hubálek, Zdenek; Rudolf, Ivo (2010-11-25). Microbial Zoonoses and Sapronoses. Springer Science & Business Media. p. 189. ISBN 9789048196579.
- ↑ Khuroo, Mohammad Sultan (2011-10-01). "Discovery of hepatitis E: The epidemic non-A, non-B hepatitis 30 years down the memory lane". Virus Research. Hepatitis E Viruses. 161 (1): 3–14. doi:10.1016/j.virusres.2011.02.007. PMID 21320558. – via ScienceDirect (Subscription may be required or content may be available in libraries.)
- ↑ Cowie, Benjamin C.; Adamopoulos, Jim; Carter, Karen; Kelly, Heath (2005-03-01). "Hepatitis E Infections, Victoria, Australia". Emerging Infectious Diseases. 11 (3): 482–484. doi:10.3201/eid1103.040706. ISSN 1080-6040. PMC 3298235
- ↑ Haffar, Samir; Bazerbachi, Fateh (2017-09-04). "Systematic review with meta-analysis: the association between hepatitis E seroprevalence and haemodialysis". Aliment Pharmacol Ther. 46 (9): 790–799. doi:10.1111/apt.14285. PMID 28869287.
- ↑ Pavio, Nicole; Meng, Xiang-Jin; Renou, Christophe (2010-01-01). "Zoonotic hepatitis E: animal reservoirs and emerging risks". Veterinary Research. 41 (6): 46. doi:10.1051/vetres/2010018. ISSN 0928-4249. PMC 2865210
- ↑ Satou K, Nishiura H; Nishiura (2007). "Transmission Dynamics of Hepatitis E Among Swine: Potential Impact upon Human Infection". BMC Vet. Res. 3: 9. doi:10.1186/1746-6148-3-9. PMC 1885244
- ↑ Li TC, Chijiwa K, Sera N, et al. (2005). "Hepatitis E Virus Transmission from Wild Boar Meat". Emerging Infect. Dis. 11 (12): 1958–60. doi:10.3201/eid1112.051041. PMC 3367655
- ↑ Kuniholm MH & Nelson KE (2008). "Of Organ Meats and Hepatitis E Virus: One Part of a Larger Puzzle Is Solved". J Infect Dis. 198 (12): 1727–1728. doi:10.1086/593212. PMID 18983247.
- ↑ Johne R, Plenge-Bönig A, Hess M, Ulrich RG, Reetz J, Schielke A; Plenge-Bönig; Hess; Ulrich; Reetz; Schielke (March 2010). "Detection of a novel hepatitis E-like virus in faeces of wild rats using a nested broad-spectrum RT-PCR". J. Gen. Virol. 91 (Pt 3): 750–8. doi:10.1099/vir.0.016584-0. PMID 19889929.
- ↑ Cheng X, Wang S, Dai X, Shi C, Wen Y, Zhu M, Zhan S, Meng J; Wang; Dai; Shi; Wen; Zhu; Zhan; Meng (2012). "Rabbit as a novel animal model for hepatitis e virus infection and vaccine evaluation". PLoS ONE. 7 (12): e51616. Bibcode:2012PLoSO...751616C. doi:10.1371/journal.pone.0051616. PMC 3521758
- ↑ Birke L, Cormier SA, You D, Stout RW, Clement, Johnson M, et al. Hepatitis E antibodies in laboratory rabbits from 2 US vendors. Emerg Infect Dis [Internet]. 2014 Apr [April 3, 2014]. doi:10.3201/eid2004.131229
- ↑ Morrow, Chris J.; Samu, Győző; Mátrai, Eszter; Klausz, Ákos; Wood, Alasdair M.; Richter, Susanne; Jaskulska, Barbara; Hess, Michael (2008-10-01). "Avian hepatitis E virus infection and possible associated clinical disease in broiler breeder flocks in Hungary". Avian Pathology. 37 (5): 527–535. doi:10.1080/03079450802356946. ISSN 0307-9457. PMID 18798029.
- 1 2 Cao, Dianjun; Meng, Xiang-Jin (2012-08-22). "Molecular biology and replication of hepatitis E virus". Emerging Microbes & Infections. 1 (8): e17. doi:10.1038/emi.2012.7. PMC 3630916
- ↑ Tao, TS; Liu, Z; Ye, Q; Mata, DA; Li, K; Yin, C; Zhang, J; Tao, YJ (Aug 4, 2009). "Structure of the hepatitis E virus-like particle suggests mechanisms for virus assembly and receptor binding". Proceedings of the National Academy of Sciences of the United States of America. 106 (31): 12992–7. Bibcode:2009PNAS..10612992G. doi:10.1073/pnas.0904848106. PMC 2722310
- 1 2 3 4 5 Purdy MA, Khudyakov YE; Khudyakov (2010). Tavis, John E, ed. "Evolutionary history and population dynamics of hepatitis E virus". PLoS ONE. 5 (12): e14376. Bibcode:2010PLoSO...514376P. doi:10.1371/journal.pone.0014376. PMC 3006657
- ↑ Shrestha MP, Scott RM, Joshi DM, et al. (2007). "Safety and efficacy of a recombinant hepatitis E vaccine". N. Engl. J. Med. 356 (9): 895–903. doi:10.1056/NEJMoa061847. PMID 17329696.
- 1 2 Park, S. B. (November 2012). "Hepatitis E vaccine debuts". Nature. 491 (7422): 21–22. Bibcode:2012Natur.491...21P. doi:10.1038/491021a. PMID 23128204.
- ↑ "HEV FAQs for Health Professionals | Division of Viral Hepatitis | CDC". www.cdc.gov. Retrieved 2016-02-26.
- ↑ Labrique, Alain B.; Sikder, Shegufta S.; Krain, Lisa J.; West, Keith P.; Christian, Parul; Rashid, Mahbubur; Nelson, Kenrad E. (2012-09-01). "Hepatitis E, a Vaccine-Preventable Cause of Maternal Deaths". Emerging Infectious Diseases. 18 (9): 1401–1404. doi:10.3201/eid1809.120241. ISSN 1080-6040. PMC 3437697
- 1 2 "Hepatitis E vaccine: WHO position paper, May 2015" (PDF). Releve epidemiologique hebdomadaire. 90 (18): 185–200. 1 May 2015. PMID 25935931.
- ↑ "Hepatitis E Treatment & Management: Medical Management, Diet and Activity".
- ↑ Kamar, Nassim; Izopet, Jacques; Tripon, Simona; Bismuth, Michael; Hillaire, Sophie; Dumortier, Jérôme; Radenne, Sylvie; Coilly, Audrey; Garrigue, Valérie (2014-03-20). "Ribavirin for Chronic Hepatitis E Virus Infection in Transplant Recipients". New England Journal of Medicine. 370 (12): 1111–1120. doi:10.1056/NEJMoa1215246. ISSN 0028-4793. PMID 24645943.
- ↑ Lozano, Rafael (2010). "Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010" (PDF). The Lancet. 380 (9859): 2095–128. doi:10.1016/S0140-6736(12)61728-0. PMID 23245604. Retrieved 27 February 2016.
- ↑ Navaneethan, Udayakumar; Mohajer, Mayar Al; Shata, Mohamed T (2008-11-01). "Hepatitis E and Pregnancy- Understanding the pathogenesis". Liver international : official journal of the International Association for the Study of the Liver. 28 (9): 1190–1199. doi:10.1111/j.1478-3231.2008.01840.x. ISSN 1478-3223. PMC 2575020
- ↑ Lewis, Hannah C.; Boisson, Sophie; Ijaz, Samreen; Hewitt, Kirsten; Ngui, Siew Lin; Boxall, Elizabeth; Teo, Chong Gee; Morgan, Dilys (2008-01-01). "Hepatitis E in England and Wales". Emerging Infectious Diseases. 14 (1): 165–167. doi:10.3201/eid1401.070307. ISSN 1080-6040. PMC 2600160
- ↑ "WHO | Hepatitis E in Chad". www.who.int. Retrieved 2016-02-27.
- ↑ "WHO | Hepatitis E in Sudan". www.who.int. Retrieved 2016-02-27.
- ↑ Teshale EH, Howard CM, Grytdal SP, et al. (January 2010). "Hepatitis E epidemic, Uganda". Emerging Infect. Dis. 16 (1): 126–9. doi:10.3201/eid1601.090764. PMC 2874362
- ↑ Nurul Islam Hasib (June 14, 2011). "Hepatitis E sounds alarm". bdnews24.com. Retrieved June 20, 2012.
- ↑ "Investigation of Hepatitis E Outbreak Among Refugees — Upper Nile, South Sudan, 2012-2013". www.cdc.gov. Retrieved 2016-02-27.
- ↑ Hereward Holland (February 2, 2013). "Hepatitis outbreak kills 88 in South Sudan—aid agency". Reuters. Retrieved February 6, 2013.
- ↑ "Nine killed, 6000 fall ill due to Hepatitis E in Morang". Republica. 8 May 2014. Retrieved 4 August 2014.
- ↑ "Hepatitis E cases in Namibia rise to 490 - Xinhua | English.news.cn". www.xinhuanet.com. January 28, 2018.
- ↑ Mirazo S, Mir D, Bello G, Ramos N, Musto H, Arbiza J (2016). "New insights into the hepatitis E virus genotype 3 phylodynamics and evolutionary history". Infect Genet Evol. 43: 267–73. doi:10.1016/j.meegid.2016.06.003. PMID 27264728.
Further reading
- Riveiro-Barciela, M (2013). "Hepatitis E virus: new faces of an old infection" (PDF). Annals of Hepatology. Retrieved 27 February 2016.
- Parvez, Mohammad Khalid (2013-01-01). "Chronic hepatitis E infection: risks and controls". Intervirology. 56 (4): 213–216. doi:10.1159/000349888. ISSN 1423-0100. PMID 23689166.
- Aggarwa, Rakesh; Gandhi, Sanjay (December 2010). "A systematic review on prevalence of hepatitis E disease and seroprevalence of hepatitis E virus antibody" (PDF). World Health Organization. WHO/IVB/10.14.
External links
|External resources
|Wikimedia Commons has media related to Hepatitis E virus.
- Virus Pathogen Database and Analysis Resource (ViPR): Hepeviridae
- Bjorn, Genevive (18 October 2010). "The night my liver started running my life". New York Times.


text: God is love and He lives inside of you. Because He lives inside of you, you have the ability to love as He does. You can be an example of what it means to accept, forgive, and love with no strings attached. This Cherished Girl denim cap not only looks amazing, but spreads the amazing message of God's love. From a day at the mall to a fun night out on the town with your girlfriends, this cap shares the easy to understand message of Jesus: He loves everyone. Telling others about Jesus doesn't need to be some hyped up or fire and brimstone message. The message of heaven and salvation is love through a relationship with Christ. That doesn't mean you don't share the truth or the consequences of not confessing Christ as the One and only way to heaven, but you can share the truth from a heart of love and with words of love. And with this Cherished Girl hat it's easy to talk about the love of God.

subset: commoncrawl


text:
Episode 39 - Platinum Blonde/
"Platinum Blonde" starring Robert Williams, Jean Harlow, and Loretta Young. Robert Williams plays a savvy newspaper reporter who falls for a rich socialite. Things get tense when it isn't clear who wears the pants.
Director: Frank Capra
Costumes: Edward Stevenson
Studio: Columbia Pictures
Year: 1931
Helpful Links:
Silver Screen Modes by Christian Esquevin-
A blog about classic movie costume design & fashion. *His Great-Great Aunt was Marie Ree, Head Cutter-Fitter at RKO (worked with Walter Plunkett) This 2016 post is on RKO Studio Wardrobe's Golden Age, and discusses Edward Stevenson:
GlamAmor: History of Fashion in Film (Great post from 2014 on Jean Louis, Head Designer at Columbia & Loretta Young)
Lady Eve's Reel Life – Great post from 2011 on the film called "Platinum Blonde & Beyond"


text:
GREENSBORO, N.C.—Guilford's men's basketball team released its 2018-19 schedule Friday. The Quakers tip off this season with two exhibition games versus NCAA Division I opponents. They first travel across town to play High Point University October 30. The Big South Conference member is coached by former national coach of the year Tubby Smith, who makes his debut as his alma mater's head coach. In the past, Guilford and High Point were rivals in the Carolinas Conference, and High Point leads the series, 81-42.
The Quakers head to the University of Iowa for their second exhibition game, a November 4 contest with the Big Ten Conference member. The Hawkeyes are coached by former UNC Greensboro mentor Fran McCaffrey.
The Quakers also participate in the University of Mary Washington Tournament in November and host the Guilford College Classic in December. They play in Fredericksburg, Virginia. Nov. 17-18 against Mary Washington and N.C. Wesleyan College. The Quakers host Greensboro College and Muskingum University in the Guilford College Classic Dec. 29-30.
Guilford opens its Old Dominion Athletic Conference (ODAC) schedule at Virginia Wesleyan University Nov. 25. The Quakers split last year's regular-season series with the Marlins. Guilford hosts its first home ODAC contest against the University of Lynchburg Dec. 5. The Quakers host defending ODAC champions and Division III playoff participants Emory and Henry College on February 13.
Head coach Tom Palombo and the Quakers are coming off a 15-12 (10-6 ODAC) campaign. The Quakers lost to Washington and Lee University in the second round of the 2018 ODAC tournament. Palombo expects as many as 11 returners from last year's squad.


text:
Men's Edition: Product Review - Daily Facial Cleanser and Moisturizer
We received these men skincare products over the mail. Here's a product review by contributors Danny and Ari.
Which facial cleanser and moisturizer do you use daily?
By Danny P.
Although I received this cream over the mail for the blog, I've been using Neutrogena's Triple Protect Face Lotion for a while now. I have found it to be great for when I head out to work, out for the weekend, or right before bed. It leaves a pleasant and subtle citrus scent. Because it also helps soothe your face after a shave, it can be a tad greasy, but nothing that will leave a shine. The bottle is perfect for your gym or work bag and fits well with toiletries when you travel. With SPF 20, it will do well to protect your skin against sun rays.
I've been interested in trying out the Age Fighter Moisturizer but never tried it because it's slightly smaller than the Face Lotion and usually double the price. I was also turned away by the name as I'd like to believe I have a few good years left in my youth before I worry about wrinkles. After trying it for a week though, I will definitely switch over to the Age Fighter Moisturizer. It has a scent similar to sunscreen right out of the bottle but is fragrance-free once applied. It leaves your skin feeling fresh and elastic without leaving a shine or oil. With SPF 15, you are reassured to have protection if you're out in the sun.
I'll still use the Face Lotion from time to time, but my go to from now on will be the Age Fighter Moisturizer. If the added Retinol and multi-vitamins does in fact help keep my skin looking young, then all the better.
By Ari H.
I've been using the Neutrogena Men Invigorating Face for about a week or so. This is not your average face wash, so push aside your old teenage products and get fresh with something manly. After using the wash, you can see, feel and smell the cleanliness within your first wash. A small pea size amount can really work up a lather. It doesn't exfoliate, but even through the beard, I felt it working and it left a refreshing cool feeling as well.
I liked that after rinsing, I didn't feel any soap, or overly dry skin. It really leaves the face clean and ready for some added protection such as moisturizer, beard oil or sunscreen.
Tell us, what's your go-to facial cleanser and moisturizer?


text:
Haiti Prison Break
Latest news & top stories about Haiti Prison Break, Haiti News and Top Stories. Read the following articles about Haiti Prison Break
Haiti prison break attempt in Gonaives failed
Published July 16, 2018 7:41 AM Comments (1)
There was a attempted prison break in the Haitian city of Gonaives Sunday night. The attempt failed leaving 4 prisoners wounded.
FLASH: 3 Prisoners escape from Croix-des-Bouquet prison in Haiti Wednesday
Published June 7, 2018 2:00 PM Comments (0)
3 prisoners escaped from the civil prison of Croix-des-Bouquets Haiti Last night, Wednesday. No details so far as to how they escaped or how dangerous these prisoners are.
Haiti Prison Break - 8 Inmates escape from Petit-Goave Prison
Published October 10, 2015 5:27 PM Comments (1)
There is another Prison in Haiti... This time in Petit Goave prison... 8 prisoners escaped at the Prison Civile de Petit-Goave early Friday Morning around 4 am... According to news reports, 3 of the escaped convicts were receiving a life sentence...
Haiti - Problem nan Prison Civile de Jacmel - Prisonier yo ap eseye sove...
Published March 9, 2015 3:09 PM Comments (3)
Haiti - Genyen yon gro problem nan Prison Civile Jacmel la... Dapre nouvel yo, gen yon group prisonier ki ale benyen, epi yo refisze retounen nan prison an... La police encercle zone la sanble gen kek ki anvi sove...
FLASH - Haiti - Prison Break in Cap Haitien Early Saturday 20 September 2014
Published September 20, 2014 9:24 AM Comments (0)
Breaking News - There is another Haiti Prison in Haiti, this time in Cap Haitien prison... 5 prisoners attempted to escaped at the Prison Civile du Cap Haitien early Saturday Morning 20 Sep 2014, around 2 am, two were stoped by police and 3 got away...
Haiti Prison Break was to Liberate Clifford Brandt, Haitian Police Confirms
Published September 19, 2014 8:50 AM Comments (1)
The BIG Haiti prison break that took place at the Prison Civil de Croix-des-Bouquets last month was designed get Clifford Brandt out of prison, says police Inspector Genreal Ralph Stanley Jean Brice... Five Haitian police officers participated in the prison break and they were motivated by money he says...
Haiti Prison Break Update - 11 Escaped Convicts Captured in The Dominican Border
Published August 17, 2014 7:45 AM Comments (2)
Haiti Prison break update - Dominican Authorities have announced that they have captured 11 of the prisoners who escaped from the Prison Civile at Croix des Bouquets as they try to enter the Dominican Republic...
Haiti - Clifford Brandt now imprisoned at Penitencier Nationale
Published August 15, 2014 6:25 AM Comments (0)
Haitian prisoner Clifford Brandt who escaped form Prison last week is not imprisoned at the National Penitentary (Penitencier Nationale)... Besides Kidnapping charges, Clifford Brandt is now being charged with ESCAPE (evasion)...
SCOOP: Haiti Police capture two more escaped convicts La Gonave Island
Published August 14, 2014 6:56 AM Comments (2)
Haiti Prison Break Update -- Haitian police captured two more escaped convicts in the island of La Gonave Haiti... This is the latest information that Haiti Prime Minister Laurent Lamonthe released to the press regarding the prison break at Croix-des-Bouquets...
Haiti - Senate Andrice Riche di: Menm Chanyy (shoeshiner) kay Brandt ka ofri YON MILLION dollar pou fe moun pe
Published August 12, 2014 7:14 AM Comments (4)
Sou zafè Clifford Brandt ki sove nan prizon an, Haiti Senateur Andrice Richè fe konnen ke "Menm Chanyy (neg k-ap netwaye soulye) lakay Brandt kapab ofri YON MILLION dollars" pou pe djòl nenpot moun ki ta anvi di ki kote Clifford Brant ye pou touche ranson ke lapolis dispoze bay la... Dapre Senatur Riche, Famille Brant la gen anpil lajan e yon million goud ke gouvenman an ofri a poki pret pou ase pou yo ta jwen Cliffort Brandt


text:
Path of Exile Developer Interview and Upcoming Content Previews
Category: News ArchiveHits: 1030
The folks at Grinding Gear Games have published an in-house interview with one of their visual effect artists. The interview will mostly be of interest to those who enjoy looking under the hood and are interested in visual effects. It even has some advice for aspiring visual effects artists. And for the rest of us, the interview is filled with flashy animations. Here are a few sample questions:
Hi Natanel! Thanks for the interview! Could you please introduce yourself and let us know about your history with art?
Hi! I'm Natanel. I've been doing VFX specifically for just over 5 years now and have been a VFX Artist at Grinding Gear Games for almost 2 years.
I'm originally from London, where my game art was more hobbyist than professional, and mainly limited to basic 3D generalist work or graphic design. However I was intent on getting my way into the bigger world of our game industry somehow, so I came to New Zealand and enrolled in Media Design School's game art course.
Early on during my time in New Zealand I did some more freelance work and slowly found myself being pulled into Technical Art after discovering the magic of UDK (Unreal Development Kit) and eventually Unreal 4 when it released a few years ago. It's during this time I slowly specialised into VFX; and after graduating from Media Design School landed myself a job at Gameloft NZ - which unfortunately shut down about a year later.
When did you start playing Path of Exile?
I discovered Path of Exile via an early look on the game by TotalBiscuit on Youtube, pretty early on when it was near the end of it's closed beta. I remember being desperate to try the game out and entered a fanart contest a community member was holding to win a key. I did an illustration of Merveil, and shortly after won myself a beta key! I've been playing the game on and off ever since.
How did you end up working at Grinding Gear Games?
Shortly after the closure of Gameloft NZ I attended a meeting at the New Zealand Game Developers Conference where Chris announced that the studio was looking for an additional VFX artist in addition to other jobs.
I introduced myself to our Art Director Erik and after a short conversation, an art test and some emailing back and forth I landed myself a job here as a VFX artist.
Could you please tell us about your current role at Grinding Gear Games and what an average work day is like for you?
My VFX artist role here involves the creation of various types of visual effects, including the creation of microtransactions, player and boss skills and adding various FX-based accents and little touches to uniques and environments. Anything magical and shiney that sparkles or explodes has likely been touched by one of us VFX artists!
On an average day I could be working on things such as creating the visuals to go alongside a new player skill, creating an epic boss death effect or designing the visuals for a new skill microtransaction.
Do you have any advice for aspiring visual effects artists?
The work of a VFX Artist involves tapping into many different skillsets that come from different specialisations like animation, tech art and general 3D modelling. To make it short and sweet, here are some quick notes of advice I could give:
- Don't neglect your traditional background as an artist. Your knowledge of composition, lighting, colour, hue and value are just as vital in VFX as it is with any artistic specialisation.
- Teach yourself or get an education in 3D art for games, we use common tools and software (Autodesk Maya/3DS Max, Adobe Photoshop, game engines) to model meshes, animate rigs and paint textures.
- Look into free VFX resources, there are plenty of Youtube tutorials and free downloadable content (from the Unreal 4 or Unity marketplace for example) that you could use to reverse engineer existing visual effects and learn how to use those techniques to create your own.
And apart from that, a couple of developer posts on the official forums tease some stuff coming our way in the 3.1.0 update for Path of Exile. The first one shares five somewhat cryptic facts about the update, and the second one shows off the upcoming unique items. Here are the facts, and you can take it from there:
- There is a new boss in Act Nine
- We have the first ever socketable belt coming
- Green and black are the colours of a new league
- We've prepared a new stash tab type for this expansion
- There are 4 new skill gems and 6 support gems coming


text:
Indonesia's Ambassador in USA
I don't think that it would be happen, I just meet with Dino Patti Djalal some days ago, and now he is an ambassador of Indonesia to USA. Wow. He inaugurated by Indonesia's President at 10 august 2010. he is very incredible and lucky man! He was actually be an assistant of president and accompany president and foreign minister, Marthy Natalegawa when attended in G20 Meeting at Toronto, Canada.Dino who introduced Modernisator Movement when Indonesia Youth Conference 2010, last July really famous everywhere. Not only inside of country but also overseas. He is really brilliant and clever diplomat. May be you are curious with his profile, you can read more at his official site,http://dinopattidjalal.com/en/page-aboutme.html
He argued when VOA intervied that Indonesia and USA relationship is an important fitur for indonesia's diplomatic to each other and something related with international world. USA is a superpower country, and Indonesia is a bigest country in the southeast asia. USA is the bigest country in economy in the world, and indonesia is the bigest activator in economy in the world. Indonesia is the muslim's bigest country and most muslim's polulated than all country in the middle east. So there are any stratgical interest that make Indonesia have to get more coorporation with USA.
Indonesia's president suggest to make strategic partnership, not alliance, but a partnership which both of countries could work together for interest strategic each country. Wow! Very brilliant!
So according to me there is mutualism unsure between these two countries. It seem a good idea, but what it not seem like a short relation plan? Why not make a serious relationship, I mean not make relation for interesting only? But partnership for over time until Indonesia could become the country needed and calculated later. But I don't know. Wish he luck with his diplomacy.
But looked from short and long term programs of Dino, make my restlessness answer. His sort term program is cooperation in education and entrepreneurship. And for long term he want to make a constructive relation between these two countries. He want to rebuild between USA and Indonesia's Military again.
He said that one of assumption from the comprehensive partnership is look for the future. Not be glued in the past. We must be able to make a new relationship based on mutual trust. That's Okay. I think that is good idea. Good luck to Dino Pati Djalal. Wish he make a real change for Indonesia.
[I'm sorry for my bad English, please correct the language and my writing is wrong, and leave me a comment, thank you = ]


text: Papercraft duo Zim & Zou are back at it with one of their most grandiose installations yet for Hermès in Dubai. Each piece is a miniature paper village populated with tiny characters, one centered around towers of fungi, the other based around blooming lotus flowers. Lucie Thomas and Thibault Zimmermann, the names behind Zim & Zou, specialize in designing and building installations out of tangible materials for advertising, product display, and as part of personal artistic pursuits.


text:
A Long Walk to Water
The New York Times bestseller A Long Walk to Water begins as two stories, told in alternating sections, about two eleven-year-olds in Sudan, a girl in 2008 and a boy in 1985.
Product Details
|HMH Books
|Publication date:
|Sales rank:
|Product dimensions:
|4.90(w) x 7.00(h) x 0.40(d)
|720L (what's this?)
|Age Range:
|10 - 12 Years
About the Author
Linda Sue Park is the author of Newbery Medal title A Single Shard as well as numerous other novels, picture books, and poetry. She lives in Rochester, NY, with her family, and has a friend who was one of Sudan's "lost boys." His story was the inspiration for this book.
What People are Saying About This
"There have been several books about the lost boys of Sudan for adults, teens, and even for elementary-school readers. But [this] spare, immediate account, based on a true story, adds a stirring contemporary dimension. . . . Young readers will be stunned by the triumphant climax."—Booklist, starred review
"[This] spare, hard-hitting novel delivers a memorable portrait of two children in Sudan. . . . Tragic and harrowing."—Publishers Weekly, starred review
"Two narratives intersect in a quiet conclusion that is filled with hope."—School Library Journal, starred review
"This powerful dual narrative packs suspense and introspection into Park's characteristic spare description; while there are lots of details offered to the reader, they come not in long, prosaic lines but in simple, detached observations. Both Salva's and Nya's stories are told with brutal, simple honesty, and they deliver remarkable perspective on the Sudanese conflict. The novel's brevity and factual basis makes the reality of life in Sudan very accessible, and readers will find both the story and the style extremely moving."—The Bulletin
"Park simply yet convincingly depicts the chaos of war and an unforgiving landscape. . . . A heartfelt account."—Kirkus Reviews
"Brilliant. . . . A touching narrative about strife and survival on a scale most American readers will never see."—BookPage
"Riveting."—The Horn Book
"[A] fast, page-turning read. . . . A great book for high school students and an important novel for young adults who enjoy learning about other world cultures."—VOYA
Customer Reviews
Average Review
Most Helpful Customer Reviews
This book was amazing with a little vilonce in it. Most events in the book did happen. This book is told by two people from diffrent times ( years ) and in the end meet up. This was a GREAT book!!!!! READ IT!!!!!!!!!!!
Powerful novel. A real page turner. Quick read. Loved the parallel stories. Park may, indeed, be recognized for this important work. A great addition to your library collection.
The author did a great job with putting it all together and tell the story. It is a very emotional book. Great non fiction read.
I absolutly loved it. Along walk to water is a personal favorite of mine and i hope to read more booksby Linda Sue Park.
This book is less than 100 pages yes but is very interesting and i recomend this book
A quick read that gives young teens an idea of what it was like in Sudan, and what happened to bring so many to the U.S. Unbiased!
I think this book is helpful, because it describe about how Africa life are shows about the Africa life is very hard. This book can remind people have the compassion, and then the people will help people on Africa. This book is talk about the true story, Nya need walk all day to get the water from the pound. Salva leave his home to the refugee camp because of war and he have chance to go to the U.S. to get new life. When he find his father still alive, he had make the decision to all Africa people have better life and his biggest problem is water. So he decide build the pond on different village. I think people should go to help people on Africa. I had learned some from this book, Salva had given me a spirit that is don't give up, work step by step. This book can also motivate people at the U.S. are from Africa. They will work harder and try harder to try to go back their country help people over there. In the book, the most impression part to me is the ending, because the two stories become the one. I think people should go to read this book, because should not just stand their own world. They should see different world on different place, and this shows different life styles between America and South Sudan. Compare other book I had read, such as: The Alchemist, The Great Gatsby and so on. It is good story, but this book let me feel little boring and the story is so straight, don't like story as The Alchemist had different feeling change at different part. I would like to recommend this book to other people who may just only care about themselves; even I don't like it very much. But it is good story, so I will give 3 starts to this book.
thhe book is cool becuase it is rold by two different people - both enemies. one comes bach and helps the other!
This book was so good. I read it at school and then i bought just to read it again. I love Salva's story it's so sad but then it gets better. Nya's story is also very good and when she would be going to school it made me smile sue lin parks you wrote a fantastic book.
Good story, a little graphic at parts, but really good
I was the one who commented below this comment the aithor came to our school today this book is soo inspiring i feel like i know salva now too bad he couldnt come but he is in sudan workimg on his project water for sudan inc. Salva is so awesome
My son and I loved this book. He read it aloud to me and I helped him with some of the more challenging concepts. My son is 9 and while the reading level was about right for him, the content is mature. I probably wouldn't have picked this book for him, but it was assigned. Nevertheless, we loved it and I will never forget the look of surprise and delight on his face as he read the last line. An idea that worked for us... keep your phone or computer handy to look things up--such as a map of Africa--as you go along.
Wow. My teacher read it infront of our class we finished the book in two days with only 1 and a half hours it was amazing, for those of you that read it is it a five stars? I thought it was it was just amazing what Salva did and how he survived and what he went threw with his uncle it was sad and it had a twist. I hope everybody will injoy this book!!!!!!!! Courtney.W
This book is so good cause i read it in school so yall need to read it!!!!!!!!
This book was so good i finshed it in on night!!!!!!!!!!!
A long walk t o water is a good book
This book is so sad. You will cry your heart out when you read it. There is trial everywhere. I hate to be a spoiler but alot of characters die. Picture yourself trying to be protected by the many wars going on. That is just how Slava felt. If you think this is all. Your wrong. So please read this book. Don't forget to carry you box of tissues. -Abbie Francis
A Long Walk to Water A long walk to water was awesome book for me because it taught me many things about life, how we have to appreciate what we have, give all of us to become a successful person en the future so that others will not subjugate us, but at the same time is was sad for me because Salva had to suffer a lot walking in search of his family, but despite all, he overcame the struggle and came to USA. In fact this book made me realize that in the world there are a lot of people that have had serious problems in the past life and we do not know the circumstances, sometimes people judge each other without thinking that those have had to beat problems to become a leader. We have to appreciate what we have, feel happy why what we have, make do with what we have, because there are many people that in their countries they have been fighting and they don't have enough food to survive, that is why we can see so many people that have died because of the lack of food, water, a place where to live or severe diseases, but the most important is that they do not have an education because of the economy, but don't complain about it while we do, even thought we have everything, the thing is that we don't know appreciate it.Yes I did, I felt affected because Salva's life was very sad , have lost his family, spend days without eating anything, knowing nothing about his family and walking every day, and he didn't know where he was going. In my case thanks God I my entire family alive so far, I have a job , education house, health , food and other commodities but ourselves block our ways sometimes or think that everything is impossible to do. In fact if we want to get something or become something we have to do. Because everything is hard, but never impossible. It has motivated me to give the best that I can, help others when someone else need, respect our parents. Make them to feel proud of us by having and education and become a successful person in the future.
I ended up loving this book! It was a short but sweet read! :D
What a good book for youth as well as adults. It is a teaching story about being helped by someone and then growing up to help someone else.
Love how there are two story lines. How these two tribes are at war but in the most recent story, they work together to create things for the kids of south sudan. Like i said this was a great true story.
I seriously loved this book. So touching and powerful. Loved the tension. So amazing!
We are reading this for a read out loud. It is amazing! Anyone that wants AMAZING book should read A Long Walk To Water! :) <3
This year we had a lot of great books I think this is a really good book and inspirintal!
This book is a teen nutmeg nominee 2012


text:
I didn't like this book but you might: A Darker Shade of Magic
Mikayla Spicer reads in between the lines of V.E. Schwab's novel, 'A Darker Shade of Magic', the first in a trilogy about magic and too many Londons.
A Darker Shade of Magic is a fun tale about a world where there are four Londons, with very few citizens able to travel in between them, and the journey of two citizens whose paths intersect. The four Londons can be broken down as such: Grey London - where there is no magic but there is a mad king; Red London - the home of our protagonist, Kell, where magic is ultra cool and accepted; White London - ruled by two crazy twins, where magic fights back against those who try to control it; and Black London - which we don't talk about.
You with me? Awesome.
I enjoyed reading this book because it's a totally original idea. However, I had issues with the characters and the world itself.
The main two characters are:
- Kell, one of two known magicians in this book universe, and he's just totally boring. He was raised as a member of the royal family of Red London, and he has mad powers. I like the idea of Kell in theory, but I didn't get a real sense of personality as I was reading.
- Lila, an inhabitant of Grey London, who pickpockets for a living. She's cool but being angry was engrained into her personality, which became tiring to read. Schwab didn't provide her backstory so she ruined the book for me because she was doing things that I didn't understand the context of, nor enjoy. However, I totally appreciated that she is a legitimately strong female character with interesting motivations.
The excitement starts when Lila steals a powerful magic stone from Kell, and they end up travelling together, albeit a bit reluctantly at first because you know, she stole from him and that's not cool, but it's interesting because they have great chemistry.
Now you know what the main premise is, here's why you should read it.
V.E Schwab's writing is excellent and engaging. She is really good at world building and writing interesting characters. Although I had issues with both main characters, they were original. The overlapping four Londons is just amazing and sucks you in. Each world has a distinct vibe and personality.
Here's a few quotes so you can get a feel for the writing style.
How inspirational. Schwab is amazing. The book isn't my favourite, but I love her style.
The book is full off sassy moments like these.
Sigh. Isn't that beautiful?
The side characters are sick. There's Rhys, Kell's 'brother', heir to the throne of Red London. He's not really given a big role but is still written as a character with heaps of potential for the sequels. Holland, the other magician who can travel in between Londons, was probably my favourite character because he's angry and complex - think Severus Snape but young and hot. And last, the crazy twins Astrid and Athos, who rule White London. They're creepy with a mean set of powers, but they have more substance than Kell and Lila in my opinion.
If you want to pick this up, you should know that A Darker Shade of Magic is now a completed trilogy. I haven't read the others, but I've heard they get really good so get keen.
Also, if you like this genre but feel as though I've kinda turned you off this book with my negativity, try The Night Circus by Erin Morgenstern because it's brilliant, or read V. E. Schwab's Vicious, which provides interesting commentary on heroes and villains and is more coherent than A Darker Shade of Magic.
Mikayla Spicer is a third-year Journalism and BCII student who likes historical fiction novels, dogs and green tea.


text: Our Wedding 'Guestbook' For our wedding Brian and I decided to have three records serve as our guestbook. My mom and I bought three records that were really cruddy from Goodwill, three record frames, foam core, and some sticker paper (it was really thick and gray under the white) from Hobby Lobby. We printed the illustrations I did for the invites onto the sticker paper. We then cut the labels out, slightly larger than the original label, and stuck them on. We then used hot glue to mount the records to foam core we cut to fit inside the frame. At the reception we had the mounted records laying on a table with gold Sharpies so everyone could sign. The Sharpie bleeds just a bit in the ridges, but I like the blur. Brian's little sister signed all three of the records! After we came back from our honeymoon we popped them into their frames and hung them. We chose a wall you can see as soon as you step into our apartment. I love that they will look good in any space we live in, and we're always going to be music fans! ♥ Mallory *** first photo by the ever lovely Sarah of Arrow & Apple. Mallory Makes ThingsSeptember 11, 2013Brian, diy home, diy, vinyl, wedding, Music2 Comments Facebook0 Twitter LinkedIn0 StumbleUpon Reddit Tumblr 0 Likes


text:
Disease Markers
Volume 2015, Article ID 614145, 9 pages
Copeptin Testing in Acute Myocardial Infarction: Ready for Routine Use?
Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria
Received 6 October 2014; Accepted 12 January 2015
Academic Editor: Serge Masson
Copyright © 2015 Sebastian Johannes Reinstadler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Suspected acute myocardial infarction is one of the leading causes of admission to emergency departments. In the last decade, biomarkers revolutionized the management of patients with suspected acute coronary syndromes. Besides their pivotal assistance in timely diagnosis, biomarkers provide additional information for risk stratification. Cardiac troponins I and T are the most sensitive and specific markers of acute myocardial injury. Nonetheless, in order to overcome the remaining limitations of these markers, novel candidate biomarkers sensitive to early stage of disease are being extensively investigated. Among them, copeptin, a stable peptide derived from the precursor of vasopressin, emerged as a promising biomarker for the evaluation of suspected acute myocardial infarction. In this review, we summarize the currently available evidence for the usefulness of copeptin in the diagnosis and risk stratification of patients with suspected acute myocardial infarction in comparison with routine biomarkers.


text:
It's summertime which means I don't like to heat up my house by turning on my stove or my oven. I love making salads with leftover protein. We had leftover Tri-tip roast medium rare. It was so beautiful to look at. It was just my son and me for dinner. I decided to make a Tex-Mex dressing to go with my salad. I did have to revamp my recipe just a tad. Make sure that if you are following a grain-free, refined sugar-free diet to check your labels. One of the reasons I have to make most everything I eat from scratch.
This recipe was inspired by Mexican spices and Fajitas. I like this creamy spicy salad dressing. If you would like to make this as a dip add more sour cream and refrigerate for an hour or more until it thickens. Use with Build a Tex-Mex Salad, Lettuce Wrapped Chicken Tacos, and Tex-Mex Taco Sauce.
Nutritional Facts are listed below and are based on 1 teaspoon per serving.
Creamy Tex-Mex Dressing
1/4 cup homemade mayo
1/4 cup coconut sour cream or store bought sour cream
1 tablespoon Tex Mex Taco Sauce
2 teaspoons Picante sauce or homemade
1/4 teaspoon cumin
1/8 teaspoon cayenne pepper
1/8 teaspoon chipotle pepper
1/2 teaspoon minced garlic
2 teaspoons fresh lime juice
lime zest of half a lime
pinch of salt
if you want it spicier add Cholula
Mix together the homemade mayonnaise and the coconut sour cream in a bowl large enough to handle a little over 1/2 a cup of dressing. Add L's Sauce, Picante, cumin, cayenne pepper, and chipotle pepper. Using a microplane mince garlic into the dressing. Add lime juice, lime zest and salt to taste. Use on my Build your own Tex-Mex steak salad.
|Nutrition Facts
|Servings 24.0
|Amount Per Serving
|calories 23
|% Daily Value *
|Total Fat 2 g
|2 %
|Saturated Fat 1 g
|3 %
|Monounsaturated Fat 0 g
|Polyunsaturated Fat 0 g
|Trans Fat 0 g
|Cholesterol 4 mg
|1 %
|Sodium 25 mg
|1 %
|Potassium 1 mg
|0 %
|Total Carbohydrate 1 g
|0 %
|Dietary Fiber 0 g
|0 %
|Sugars 0 g
|Protein 0 g
|0 %
|Vitamin A
|1 %
|Vitamin C
|0 %
|1 %
|0 %
|* The Percent Daily Values are based on a 2,000 calorie diet, so your values may change depending on your calorie needs. The values here may not be 100% accurate because the recipes have not been professionally evaluated nor have they been evaluated by the U.S. FDA.


text:
You get more Leads to your business with us!
Our central goal is to help our clients get the best moving administration at focused and attractive rates
Moving organizations are a central piece of our site. We plan and help moving organizations achieve their potential clients need faster.
USMOVEU was founded by a mover who hails from Florida with over 20 years of experience in the moving industry.
We give administrations to neighborhood moves, long-separation moves, interstate moves, universal moves, and auto transport.
USMOVEU, having quality targeted moving related links in our moving websites network, work hand in hand with a wide groups of professional movers committed to give better client administration as regards moving.
We are as well giving quality leads, who are ready to move, to qualified moving organizations.
Prior to partnering with us as a moving company, our movers are usually subjected to a serious screening procedure. Utilizing government databases and the organization's profile on the Better Business Bureau, every individual moving organization's licensure, protection, and notoriety are checked.
In the event that we recognize any warnings, we simply say no and bar the moving organization from entering our system.
Our moving lead management website is McAfee verified a worldwide pioneer in infection and malware insurance, every day to ensure against hacking assaults and extortion.
Ensuring your protection and progress is our concern. The individual data you submit is utilized just for moving purposes and new home utility administrations, and your data is never sold to inconsequential outsiders.
We keep it sheltered and secure; keeping in mind the end goal "to protect you and ensure you succeed".
We offer high quality moving leads for less. We offer business moving leads and private moving leads at reasonable rates.
Our claim to fame is the interstate moving leads and expert moving leads for interstate transporters and moving organizations.
As we are the top US moving leads supplier, we offer just top quality leads ready to move to numerous moving companies who are qualified and insured.
This should tell you that USMOVEU cannot compromise as regards the safety of your business. With our full dedication to serve you and an impeccable reputation for quality, we always want our moving partners to thrive significantly.
Contact us today for more data and estimating of the moving organization leads, partner with the best lead providers and skyrocket your business base.
We generally have the right response to the everlasting inquiry for each moving organization.


text:
When President Barack Obama announced the "one-time gesture" of releasing Iranian-born prisoners who "were not charged with terrorism or any violent offenses" last year, his administration presented the move as a modest trade-off for the greater good of the Iran nuclear agreement and Tehran's pledge to free five Americans.
"Iran had a significantly higher number of individuals, of course, at the beginning of this negotiation that they would have liked to have seen released," one senior Obama administration official told reporters in a background briefing arranged by the White House, adding that "we were able to winnow that down to these seven individuals, six of whom are Iranian-Americans."
ut Obama, the senior official and other administration representatives weren't telling the whole story on Jan. 17, 2016, in their highly choreographed rollout of the prisoner swap and simultaneous implementation of the six-party nuclear deal, according to a POLITICO investigation.
In his Sunday morning address to the American people, Obama portrayed the seven men he freed as "civilians." The senior official described them as businessmen convicted of or awaiting trial for mere "sanctions-related offenses, violations of the trade embargo."
Join your fellow Libertarians who seek a world of liberty; a world in which all individuals are sovereign over their own lives and no one is forced to sacrifice his or her values for the benefit of others. Join over 500,000 Americans who get their daily dose of minimal government and maximum freedom with The New Liberty Movement.
We know how important your privacy is and your information is SAFE with us. We'll never sell
your email address and you can unsubscribe at any time directly from your inbox.
View our full privacy policy.


text:
Why does The Joy List exist?
Shoutout to Chase Costner for putting this amazing sizzle reel together
Americans are lonely. The average person in the U.S. has only one close friend. And to make things worse, 75% of people say that they're unsatisfied with their friendships. Religious gatherings are on the decline, but new ways to gather in community are hard to find. How do we fix this?
Our mission is to reduce loneliness in the United States, starting with New York City. We do this by compiling events that have a facilitated moment of connection. The majority of our listings are $30 or less, and many are free. We give people the little nudge they need to get out of their comfort zone, and into an experience where they can make a new friend.
We lift up the work of other community organizers. We let people know that they're not alone in feeling lonely. And we prioritize getting off our devices, and into real-life connection.
Want to help? Contact us.
We also host a monthly-ish event!
People Kinda Like Us
They're not the only ones! Check out more reader love here.


text:
Are you feeling stuck in the mud? Or perhaps stuck in a belief? This Wednesday, August 3, join Rev. Kim Kaiser as he looks at how we get stuck and what works to get us moving again. Ernest Holmes, author of the Science of Mind textbook, has some intriguing thoughts on this topic.
Plan to stay after service. There'll be light snacks and friendly conversation.
The service beings at 7 pm. All are welcome.


text:
Wednesday, October 31, 2007
The Horror, The Horror
I guess I just don't see it. I see the movie and, while I can appreciate it as a movie, I find it rather sad to see all the people who believe it is "real."
That said, I rather enjoy good horror movies. They really can't scare me anymore, but I still enjoy them as cinematic experiences. And apparently my two-year old likes them too. Now before you start calling social services, it is not like I'm making her watch slasher films. But 'Alien' and its sequels have been on cable at home and I've caught some of each and while my daughter pretty much ignores most programs I like to watch (she just plays) she will stop and watch the Alien movies with intense attention. I think she's going to be a horror fan. (Her mother can't watch horror movies - she gets scared - she said her mother would never let her watch them and would cover her eyes for any scary parts of movies she did watch - now she can't watch them). I think that is rather silly. They are just movies. My daughter is two and she seems to get that more than my wife. Now one movie I would NOT want my daughter to see is the end of Fast Food Nation - she ended up seeing part of that when it was on cable and I had no idea that it ended with showing cows being slaughtered. This was bad because my daughter LOVES cows, for whatever reason. My wife was sitting next to her and heard her say "uh oh, uh oh, cows, poor cows, uh oh" with increasing alarm before my wife noticed what it was and turned it off.
We do try to watch what we watch when our daughter is watching. I don't want her watching stuff age-inappropriate. It will be interesting to deal with the fact that we have like 200 cable channels when our daughter is older and figures out how to watch TV on her own. Right now she just likes watching her DVDs and Disney Channel. (And I try to limit how much TV she watches - my wife tends to like to just turn it on to make her happy - another reason I'm glad my daughter goes to day care where there is no TV).
Oh, and kudos to anyone who identifies what movie has the line that matches the subject for this post. (And even more Kudos if you can identify the book).
6 comments:
It's from "Heart of Darkness" originally, so the lines must come either from the film version of the novella or from "Apocalypse Now."
Is there somewhere on the internet where you can change kudos for pounds sterling?
- October 31, 2007 at 5:25 PM
For me the worst was "Alien". All the crawling around in a dark ship waiting to be preyed on put it over the top for me.
- October 31, 2007 at 5:29 PM
- Revenant said...
For me it was the last segment of Trilogy of Terror, with Karen Black. There was this little Zuni Headhunter doll that came to life. It should have been comical, but it scared the crap out of me when I was a kid.
- November 1, 2007 at 11:41 AM
- hedera said...
Well, I can't get credit because tom nolan got there first, but honest, I did guess "Heart of Darkness" for the book...
Otherwise, sorry, I don't do horror movies; although I occasionally go back and read H. P. Lovecraft stories.
- November 3, 2007 at 12:12 AM
- DBB said...
Yep, Heart of Darkness - repeated in Apocolypse Now - which is funny in that a book set in like 1912 or something like that is essentially made into a movie in Vietnam, with surprisingly few changes overall, given the huge shift in time and space.
I've always enjoyed that book. I liked 'The Secret Sharer' as well. And I LOVE HP Lovecraft - there's just something so creepy about his writing.
- November 3, 2007 at 1:40 AM
- hedera said...
Yes, Lovecraft does creepy atmosphere better than almost anyone.
- November 3, 2007 at 5:32 PM


text:
Four Stanford Affiliates Reach Finals At 2005 Summer Senior Nationals
Aug. 4, 2005
Irvine, Calif. - Four Stanford women's swimming affiliates reached the 'A' finals of their respective events on the second day of competition Thursday at the 2005 ConocoPhillips Summer Senior National Championships. The performances were highlighted by fourth-place showings from sisters Tara and Dana Kirk. Tara (2000-04) was fourth in the 200 breast in a time of 2:29.83, while Dana (2005-06 senior) took fourth in the 200 fly in 2:11.79. Andrea Axtell (2005-06 freshman) was sixth in the 200 back (2:14.77), while Caroline Bruce (2005-06 sophomore) placed seventh in the 200 breast (2:31.68, 2:31.15 prelims). All four swimmers had qualified higher in the prelims of their events.
Brooke Bishop (2005-06 sophomore) competed in a pair of events, taking 16th in the 100 free (57.56) and 20th in the 200 back (2:18.44, 2:17.63 prelims). Laura Davis (2005-06 senior) ended up 24th in the 200 fly (2:18.25) and 32nd in the 200 breast (2:36.00, 2:35.88), while Kristen Caverly was entered in both the 200 back and 200 fly but did not swim in either.
All Stanford affiliates were swimming for Palo Alto Stanford Aquatics other than Axtell (Longhorn Aquatics) and Davis (Terrapin Swim Team).
Individual event winners on Thursday were Amanda Weir of Swim Atlanta-GA (100 free, 54.47), Rebecca Soni of Scarlet Aquatic (200 breast, 2:26.27), Leah Retrum of the Donner Swim Club (200 back, 2:11.00) and Wildcats Aquatics' Elaine Breeden (200 fly, 2:09.85).
The five-day long-course meters meet that began Tuesday at the William J. Woollett Aquatic Center will continue with the third day of action Friday and run through this Sunday, August 7. Heats start each day at 9:00 am, PT, while the finals session is scheduled to begin at 6:30 pm, PT.
Pac-12 PlaylistTODAY | 10:00pm PTLive
TOMORROW | 4:00pm PTLive
Airing on:
- Pac-12 Network
- Pac-12 Bay Area
- Pac-12 Los Angeles
TOMORROW | 8:00pm PTLive
Airing on:
- Pac-12 Network
- Pac-12 Los Angeles


text:
e-NABLE.org is a prototype for ConnectedHumanitarians.org an emerging generalization of the e-NABLE model. "Connected Humanitarians" (aka Humanitarian Makers) are volunteers using emerging technologies (not just 3D technologies) to address unmet needs of underserved populations. The initial focus is on healthcare and assistive technologies, but the model is even more general.
A project of:
- e-NABLE.org (and Jon Schull)


text:
If you look at the people around you, chances are the fit and lean for the most part of their lives are those who are actively engaged in sports they love and for which they are willing to do-rain or shine.
And with the erratic weather brought about by climate change, the best time is any day the weather permits.
There really is no best time to engage in sports; anytime is the best time if you're really interested.
Today is just a good a day to discover what activity you'll enjoy with emphasis on the joy.
As in work, so too in sports: do what you love and the fitness, if not the weight loss, will follow.
Think of it as a series of mini adventures within your community for the remaining months of the year, not a grand goal carved in stone.
Brisk walk (even just to your car or the length of a mall's hallway when shopping), then run in your neighborhood (or even just walk down the stairs in your office or home building), bike on a borrowed or rented one, swim in a public pool in your area, do aerobics or dancing or martial arts near your home or workplace, take badminton, tennis , golf or fencing lessons (or whatever is available and affordable) and if your health is up to it, engage in extreme sports on weekends.
Begin with the first step: organize your sports gear and exercise stuff in a bag dedicated for that purpose alone so you're always ready to hit the street or the court or the pool anytime you find yourself even with just an hour on your hands.
And all it takes is one hour three times a week at least.
Chester S. Ching, vice president for marketing of Hawk Bags, multi-award winning manufacturer of quality bags since 1978, says that when his company was doing research on customers' needs for a sports bag, he found out that one of the major reasons people are not able to exercise or engage in their favorite sports more often is that they were not organized for the change of clothes and gear needed to shift to exercise mode.
Tim Lyncecum See details


text:
According to The Spruce link, "Kinako is one of many Japanese ingredients made from soybeans. It is dried, milled and roasted soy bean flour. It is golden tan in color and has a powdery texture similar to that of all purpose flour. It has a warm, toasted and nutty aroma, and its flavors are similarly nutty and slightly reminiscent of roasted peanuts."
Ok, cool.. flour flavor lmao.. hmm.. what the heck! I did my standard 4 drops in 10ml and let it sit up 3 days.. and the weird thing is.. I am picking up the flour, and I get a powdered effect all inside my mouth. Very little roasted nut, so might try backing down and using 2 drop in 10ml.
I still have yet to toy with a good recipe.. I have gotten the flour out of my mouth now.. thinking on a few things.. will report back once I have something working. Single flavor test at 2 drops from the new bottle, 10ml is much better.. I think this is comparable to the pastry zest. Might be a start for a good recipe, will see.
Here is the trick to the kinako soy, use with a form of bread/cookie/macaroon etc and the helper is Pastry Zest!
Blueberry Pancakes!


text:
Carneys will begin loading waste into its brand new composting facility next week.
The first load of waste through the facility will mark the beginning of a 30-day trial period until the system becomes fully operational.
On Monday the Squamish-Lillooet Regional District board members approved the final steps to get the composting facility up and running.
The SLRD approvals mean Carneys can now import organic waste from the Greater Vancouver Regional District.
This is just a temporary measure until the SLRD and its member municipalities can put in organic waste support mechanisms such as banning organics at the landfill. This will allow enough local food to get to the composting facility and eventually end the need to import the organic material.
The second approval from the SLRD will allow Carneys to use clean, segregated wood waste and dimensional lumber from the regional construction industry in the composting facility.
Generally construction and demolition waste is excluded from composting operations in case it contains toxic materials like pressure treated wood, paint and plastic. But clean, segregated wood is an essential part of the feedstock for Carneys composting operations.
The state of the art facility is located in Squamish. The first load of waste will be tested out on Wednesday, Feb. 4.
Conservation Officer attempts to honour slain Game Warden
Sir William Logan, the surveyor who made Canadas first geological maps in the 1800s, got one and now a B.C. Game Warden who died 70 years ago may get one too.
Lillooet District Conservation Officer Bob Butcher is drumming up support to get a mountain in Lillooet named after Albert Farey, a fellow officer who was shot and killed in the line of duty in 1932, back when Conservation Officers were called Game Wardens.
Butcher said Farey was a man who served his country in World War I and then later his province and district as a Game Warden for 12 years in the Lillooet District
He was shot and killed in the Bridge River area on Oct. 3, 1932.
Butcher has chosen a steep rock peak close to Lillooet as the mountain to bear Fareys name.
Butcher asked the Squamish-Lillooet Regional District for a letter of support at its monthly board meeting on Monday. The letter will be part of the application process to get a mountain in Lillooet named for Farey.
Some members of the board were at first hesitant to offer support, concerned about a backlash from First Nations.
SLRD Director Greg Kamenka, who is also mayor of Lillooet, explained the position of some of the older members in the First Nations community.
A First Nations man shot Farey but there is some feeling that he had been overzealous in his pursuit of the man.
"He was doing his job, whether he was zealous or not," said Butcher.
Ultimately the board members voted to support the application process saying that First Nations will have a chance to voice their concerns further down the road.
Only two conservation officers have been killed in the line of duty in B.C.
The second officer was Dennis Greenwood. The East Kootenay Regional District has written a letter of support for naming a mountain in the Purcell Range after Greenwood.
Honouring the fallen conservation officers is part of the 100 th anniversary celebrations of the B.C. Conservation Officer Service in 2005.
SRLD Board members get raise
SLRD board members voted to give themselves a $1,250 raise each on Monday after eight years at the same pay rate.
A report showed the SLRD pays its directors less than the average in other regional districts. For example, electoral area directors on average get $9,030 compared to $7,500 in the SLRD. Likewise municipal directors on average get $5,115 compared to $3,800 in the SLRD.
The issue of remuneration sparked debate at Mondays meeting on whether electoral directors should make much more than municipal directors.
Generally the rationale for the different pay scales is that municipal directors also get remuneration for sitting on municipal councils.
"Im spending more time on regional district business then on council," said Squamish Councillor Raj Kahlon, who along with Mayor Ian Sutherland represents Squamish on the SLRD board. Both called for increases for municipal directors.
Russ Oakley, director of Electoral Area A, said: "I think its probably fair to close that gap."
The $1,250 raise each will also include yearly cost of living increases.
The board also approved its priorities for 2004 at the meeting and chief among them was the Regional Growth Strategy. This was followed up by the Emergency Response Plan and transportation issues like the Rutherford Creek Bridge.
October 15, 2019, 9:32 PM
35-year-old fell while riding A-Line on Wednesday, Oct. 9 More...
October 15, 2019, 9:20 PM
Marcus Kissner was reported missing last month More...
October 15, 2019, 3:50 PM
LETTER: For the week of Oct. 10 More...


text:
The cougar in this video is caught in a trap outdoors, and the creature is in the process of being freed by two rangers. Of course, trying to handle a cougar, even when armed with restraining poles, is not the easiest thing to do at the best of times. This video documents the six-minute struggle involved with keeping the cougar still long enough to get the creature free from the trap.
The cougar hisses and lashes out at the rangers repeatedly. At certain points, the creature looks close enough to them that the viewer is going to worry that something really bad is going to happen. Fortunately, everything is fine by the end of the video and the cougar is free, but it must have been some of the most tense minutes of the rangers' lives. People should please SHARE this suspenseful and exciting video on Facebook, where it will educate and stun viewers.


text:
The fashion industry is experiencing a moment of clarity. We are in an era of blurred lines and chucked traditions. Male and Female collections are shown together, streetwear is sold and presented fluidly with century old European houses, and stereotypes of what kind of fashion comes from particular countries are fading. There are a variety of reasons fashion has entered this willingness to think beyond what is "traditional" but the primary factor would have to be the trailblazing talent in each genre. Talent forces people to expand their points of view. In the case of the Mexican fashion arena, the world is starting to pay closer attention to the vast diversity of style. This is due largely to talents with strong points of view such as Luciana Balderrama. Since the 2014 launch of her brand, Luciana Balderrama has developed a reputation for producing couture-worthy detailing and precision in each individual piece she designs. As a result, she has quietly infiltrated red carpets globally with her work.
Luciana, who studied design at The Art Institute of California, honed her skills as a designer with the renowned Cuban-American designer Robert Rodriguez. While her talents were polished on the West Coast of the United States, it wasn't until her return to Mexico that her unique talents gained traction among some of the most photographed women in Mexico. Eventually, Luciana went on to produce her first ready to wear collection for the Fall / Winter season of 2015.
Luciana Balderrama has entered the design arena with equal parts charm, passion, and vision.
The hints of vintage Thierry Mugler combined with Luciana's completely individual take on modern
Equal parts soft and complex, Luciana's work is a flirtation with femininity that doesn't need to yell or announce itself. Her approach to evening and formal is a study in blatant glamour, unrestricted yet refined.
In just over a year, Luciana's namesake label has gained a committed and impassioned following. One look at her Instagram account and it is evident that the women who wear her clothing, famous or otherwise, are emerged in the Luciana Balderrama aesthetic.
The Luciana Balderrama brand is expanding. Her recently launched e-commerce site has made her distinctive work available to masses. Soon her designs will be seen in brick and mortar retail worldwide. In the meantime, there is something fitting about the subtle, quiet storm of her rise. It's special, romantic and driven by passion alone; not unlike the clothing itself.


text:
It's such an honor to be able to photograph this sweet couple. Ashley and Alex are 2 souls that are meant to stand the test of time. They compliment each other's personality and seeing them together just makes me fall in love with them and the genuineness that they bring. Truly soulmates - both silly and sweet and really speaks true to what you see is what you get - but so much more! They met online and after pulling an all nighter chatting about all Star Wars film, they ran 5k together. The rest is history.
I had lunch with Ashley and Alex not long ago wanting to learn more about who they are. Ashley is an amazing baker and I love going to Woops just to see her. Her cheerful and happy personality brightens up my morning everyday. Alex is a musician and plays the trumpet for one of Tucson's most prestigious orchestra. Truly one of my favorite couples in Tucson.
Cheers guys, thank you for allowing me to spend the afternoon with you! xo
This is their story:
Ashley and Alex
Real. Love. Story.


text:
What I'm wearing now, & some inspiration
Hi you lot! I hope you're all so well and have had the best weekend. After asking what you'd like to see from me on Instagram Stories, lots of you said more fashion and inspiration, so I've worked on something a little bit different for you today. I'm not usually one to lose inspiration with what I'm doing, and to make sure I take in as much as I can, I look to Tumblr, Pinterest and of course, Instagram. I like to see colours, textures and shapes more than 'how to wear jeans' if you catch my drift…so I find more design led accounts more useful to me.
The season will soon be moving into Autumn, which means temperatures will drop and we'll have to start layering up. I know it's sad but the bright side in all of this is that we have to wear different things from our wardrobe or invest in some new pieces to see us through the colder half of the year, which for me, is exciting!
I've already invested in a couple of new warmer pieces that I feel will transition well going forward, and that I'll wear a lot. I've pulled the inspiration images from Tumblr on this occasion so you can see my inspiration for dressing as we move into Autumn.
The basics. Jeans and a t-shirt are my absolute failsafe. It's what I feel most comfortable in, and it's what I pull out when I can't decide what to wear. Totême have relaunched their original denim collection that allows you to choose your leg length in each wash- what a god send that is. I've ordered the washed out black/grey pair as I'm literally drowning in blue denim at home! T-shirt wise, my favourite and the best quality are Re/done. They come in at £75 but I've had mine for almost 4 years and they are brilliant, and show no signs of wear.
Shop here:
Totême straight leg, high waist jeans
Next up is this black on black look. I have the skirt that I've linked for you by Reformation but you can't get it in the UK without US shipping charges so I've found a similar one in Topshop for £9! I think back x black is so chic, and it's perfect for an evening out that can be dressed up or down and isn't a look that'll break your bank.
Shop here:
& Other Stories black silk shirt
If you followed along on my Copenhagen Fashion Week trip, you'll have noticed that I bought some new Fendi mules. They are quite easily, my pride and joy, and they live in a dust bag when not on my feet (which isn't often at all). I've fallen in love with the 90's logo resurgence and I really love how they can lift a basic jeans/t-shirt combination. They're super comfy after a few wears. The leather is a little bit tough at first but it soon softens up and they're the perfect height to walk for quite some time in!
Shop my shoes:
Simplicity is key for me, although I am partial to some colour, I like the shapes to compliment each other and to fit my body properly. I've said before that whilst I love oversized pieces, I really love figure hugging clothing too. This mix of vest with trench coat is the best! I've found an amazing knit vest on Massimo Dutti and the perfect oversized trench coat on & Other Stories.
Shop the pieces here:
I found the perfect transitional blazer, a la inspiration on Tumblr. I always have such amazing ones from & Other Stories, and this one is no different. I absolutely love the fit of it, with a slightly slimmer jean and trainers or a mid heel. I can't stop wearing it! It's wool too, so it'll stand the test of time.
Shop my blazer:
Thank you so much for reading and I hope you've enjoyed today's post. It's always nice to find inspiration in new ways! See you back here on Wednesday for something new. xx


text:
#TIL : Reduce init time MySQL docker image
Reduce init time MySQL docker image
Original MySQL docker image uses a script to generate ssl certificates for service. Sometime we don't really need it (connect via a docker network link or need a fast enough database service to build a automated test).
We can reduce init time by removing the script from original Docker image
FROM mysql:5.7
# Remove mysql_ssl_rsa_setup to ignore setup SSL certs
RUN rm -f /usr/bin/mysql_ssl_rsa_setup
FAST as a FEATURE !!! 🚀


text:
OSHA required training for non-laboratory employees that may be exposed to hazardous materials during the course of their employment. The OSHA standard, MSDSs, labeling and safe handling of chemicals are discussed. Department or group specific training is encouraged and can be arranged. Periodic refresher training is also required.
To request this training, please contact:


text:
Pine Meadow Remains Protected for Another Year
Apr 01, 2016 01:15PM
● By Jennifer Neys
At the March 9 city council meeting, the Martinez City Council introduced an ordinance to rescind approvals from over a year ago for the DeNova Homes 99- home development at 451 Vine Hill Way (Pine Meadow Golf Course), repealing all of the entitlements (general plan amendment for the development, rezoning and planned unit development approval, and vested tentative map) granted to this project, returning the 26-acre property to open space/recreation general plan and open space zoning.
The council's action now eliminates the November ballot referendum submitted by the Friends of Pine Meadow, the group that wanted to bring the development issue before voters. The November vote would only take away the 99-units application that was approved by the councilmembers a year ago. If the action was put to the votes, it could cost over $23,000. "This is a colossal waste of money. We can get it done without all of that cost," said Mayor Schroder. In fact, the ballot referendum would not restrict further applications, including a new development application from DeNova Homes, "provided that the new application is not substantially similar to the one that was subject to referendum," said Senior Assistant City Attorney Veronica Nebb. There is also a one-year moratorium on a substantially similar land use designation.
On December 10 last year, the city clerk received a letter from Civic Martinez, LLC, the owner of the property and DeNova Home, Inc., requesting that the city repeal the entitlements for the Pine Meadow project. The owner and developer stated they no longer intend to proceed with development of the project as originally proposed and are working on revised plans to be submitted sometime in the future.
It was suggested at the meeting that a funding mechanism be put in place for the city to try and purchase all or part of the property as parkland. However, ques- tions remain about funding sources. "If we want to spend our time wisely, let's do an initiative to find out if the majority of the town wants to pay additional taxes to have a funding source to negotiate with private property owners," explained DeNova Homes CFO Dave Sanson.
Mayor Schroder brought up that the citizens' vote for Measure H was designed to use $30 million to improve existing parks in the city with Waterfront Park as the last major overhaul, rather than spend additional funds on new parkland. Mayor Schroder said, "Nothing is going to be free, including Alhambra Highlands, and I have proposed to this council that they consider a possible half cent sales tax that will be dedicated toward infrastructure repair such as roads, sidewalks and so on."
Councilmember Lara DeLaney spoke in favor of a compromise on Pine Meadow, "We want permanent community benefit. Hopefully we can get a portion of permanent open space or some kind of a permanent community benefit there that's what we want, so let's get to that."
The city council voted 3-2 to rescind the ballot referendum and 5-5 to rescind all related resolutions. (The ordinance was adopted at the March 16 city council meeting.)


text:
I would buy another, if necessary
I originally bought this, not for the purpose it was intended for, but to achieve a sound I couldn't get for the song "Slow it down" by the Lumineers. I noticed that he had it on his guitar in videos and although it slightly gives that sound, it was a little difficult to put on my guitar. I assume it was made for a Dreadnought shaped guitar, while my guitar is a Concert sized guitar. But all in all, I got it to fit and it actually sounds pretty good when plugged in. Just a very slight muffled sound, but I like it. #Sweepstakes
Los Angeles, CA


text:
Airfare from Oakland to Vancouver
You can count on WestJet when it comes to airfare from Oakland to Vancouver. Our flights take off and land all across North America, Central America, the Caribbean and Europe, including Vancouver International Airport, which is why you can rely on us to get you where you need to be. We believe in affordable travel and exceptional customer care, so our passengers can always expect to pay less and get more. These are just some of the many reasons Canadians choose to fly with WestJet and why you should too.
Low fare finder
Don't see what you're looking for? Find all of our great low fares in one place.
A WestJet ticket is the first step of your trip to Vancity
Airport Details: From OAK, Oakland International Airport To YVR, Vancouver International Airport
When you visit Vancouver, you won't have to go far for breathtaking views of snow-capped mountains and pristine waterside views. As the host of the 2010 Winter Olympics and Paralympics, Vancouver has state of the art sporting facilities for you to see; it's also known as a destination for renowned wines and some of the freshest and tastiest seafood. On top of that, the airport is located just a few miles from the downtown core, which means you'll be sampling the city's delights almost as soon as you get there.
Rely on WestJet for airfare when you want to visit one of the most spectacular, sophisticated places in British Columbia. Whether you're travelling for business or to visit attractions like the Vancouver Art Gallery, the Vancouver Museum or Stanley Park, you can rest assured that you'll get from Oakland to Vancouver swiftly, safely and comfortably with WestJet.