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Today's Top Gainer
|Chg (%)
Note:Top Gainer - Nifty 50 More
|Whole-time Director
|Badal Mittal
|Anil Mittal
|Company Secretary
|Pushpalatha V Mishra
|Independent Director
|Poornima Sanjiv Aggarwal
|Additional Director
|Nikhil Dalmia
|Independent Director
Trans Freight Containers Ltd is engaged in the manufacture and export of marine freight cargo containers. The company also manufactures truck body panels which have applications in the pharmaceuticals, food and beverage, electronic and the White goods industries. The companys headquarter is at Mumbai. They are having their manufacturing facility located at Tarapur in Maharashtra.Trans Freight Containers Ltd was incorporated in the year 1974. In the year 1994, the company undertook an expansion-cum-modernization programme by increasing their capacity from 18,000 TEUs to 30,000 TEUs per annum at their Tarapur plant. They also implemented the 40-foot container line made by Korean technicians. During the year, the company entered into a technical collaboration with Morteo Industries, Italy, and floated a joint venture company namely, Morteo Trans-Freight Reefer Containers Ltd, for manufacturing 10,000 refrigerated containers. The plant was set up at Patalganga.In the year 1995, the company set up a joint venture, Trans Freight Polyfont Panels, with the French company, Polyfont a leading European manufacturer of composite panels - for the fabrication of trailers and truck bodies. During the year 1995-96, the company increased the installed capacity of marine cargo containers from 12,000 to 15,000.In May 2008, the company sold their entire 3,000,000 equity share of Morteo Trans Freight Reefer Containers Ltd and therefore Morteo Trans Freight Reefer Containers Ltd is ceased to be a subsidiary of the company.
Mulund I E S Co-op Society Ltd,
Nahur Road Mulund (West),Mumbai,
Tell. : +91-22-5645332
Website : http://www.tfcl.com
Email : email@example.com
Unit No 1 Luthra Ind,
Safed Pool Andheri(E,Mumbai - 400 072
Tell. : +91-22-2851 5606
Website : www.sharexindia.com
Email : email@example.com


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Brandon Scott Cope will be the first senior in Anchorage, Alaska to graudate after his death. After Brandon died all I wanted was to see him get what he worked so very hard for. He will not go to college, get married, or have kids or have a wonderful life that I wished he would have, BUT there was one thing I thought I could change and that was to get him to graduate with his senior class. Really what harm is there in that right? He was a senior and he was just a few credits short. So I went to the school where I met with Mr. Stone and he did not see where there would be a problem in this, but he knew that he had to bring it up to the "higher powers" as did I. So we both did our thing. He asked, I wrote my letter " a mothers wish" to EVERY school board member and sent it out. It did not meet with open arms with Carol Comeau and Mike Henry as they are very by the book people and told Mr. Stone "NO, Brandon does not have enough credits, he can not graduate". Mr. Stone emailed me and said what was going on but I kept on. Carol then emailed me she would meet with me in person. I figured Great now she will tell me in person. So I made it for after the holidays so I could get my "plan" into action. Little did I know sometime before xmas Scott had contacted Palins office and they contacted the office of Education (above Comeau) and they called Scott to ask about what was happening with MY WISH. He told them a little about it and said we had a meeting Friday the 12th. She wished him luck and said to please call her to let her know the "outcome".We went to the meeting loaded with all Brandon's honors stuff, transcripts, report cards, letters, things I found o the internet where seniors from other states have graduated and was just ready to fight. They asked WHY? Scott and myself explained that he was a gifted student that worked hard and was on track to graduate- had his life not been taken away from him that day. He worked hard and his senior class- from the jocks to the nerds all know him. He was not someone to just forget, that we raised $2000.00 for the orchestra. This was something that I really felt strongly about, him graduating with his 08 class at West. The four of them just looked at us and Carol smiled and said that they are going to let him graduate with honors but it will be an honoray degree because he does not have all his credits but because he was on track they did feel he would have graduated. They are not sure quite yet how it will all play out as he is the FIRST in Anchorage to be getting the honor. But they will let his name be called out and his name be in the pamphlet at graduation. Not sure if one of us gets to pick up his degree for him with his class or how it will work but I will get to "see" Brandon cross that line as I always hoped and knew he would. I just wish he was ALIVE to do it.
May 14, 2008 2.pm @ Sullivan Arena We would love for all to be there to support the family and our love for our son.

subset: commoncrawl


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Normandy '44: European Theater combines a higher level of realism with a more elaborate doctrine system, which incorporates almost 50 different military units that took part in the period of Jun-Sept 1944. This spectrum ranges from divisions of free Polish and French units serving under the main allied armies to volunteers from the Eastern Front that served in the German Wehrmacht. This is only a small portion of the doctrine variety however, as we feature numerous well known units of all factions as well. The mod also features numerous new abilities and custom made units each with a completely revamped size and structure. Between custom made units and structures with historically correct skins, Normandy '44 offers over 150 NEW UNITS, making for an almost endless variety of different scenarios and unit actions. Combined these factors provide for an experience unlike any other mod for CoH!
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WPCampus 2018 Videos Are Now Available to Watch
WPCampus 2018 was held July 12-14, 2018, at Washington University in St. Louis, Missouri. Educators, staff, and those in higher-education gathered to learn how WordPress can be and is used in higher-education environments. If you couldn't attend in person or watch the live stream, you can now watch all of (more…)


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All Anime are named by their original names (Japanese), if you are looking for Anime by english or alternative name, please use search box.
Genres : Action, Adventure, Demons, Fantasy, Martial Arts, Romance
Premiered : 2018
Summary : Tales of Demons and Gods (Season 3) - The third Season of Yao Shen Ji. ...
Genres : Action, Adventure, Historical, Seinen
Premiered : 2018
Summary : Golden Kamuy (Season 2) - Second season of Golden Kamuy....
Genres : Action, Adventure, Demons, Fantasy, Magic, Martial Arts
Premiered : 2018
Summary : Ken En Ken: Aoki Kagayaki is based on the 2004 Taiwanese role-playing game Xuan Yuan Jian Waizhuan: Cang zhi Tao, whose story is set in the Spring and...
Genres : Adventure, Comedy, Fantasy, Historical, Kids, Shounen
Premiered : 2000
Summary : Doraemon Movie 21: Nobita no Taiyou Ou Densetsu - Doraemon and its friends open a hole in the time and they're travel to the Country of Mayana, a lost...
Ohayou minna-san, support us and like our page if you wanna see new episodes links, Anime and Manga news, vines, funny pics and more 🙂


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Category life and death
These Happenings Can Only Occur Once In a Lifetime
I usually do not put a video on the blog but this one is quite good. My friend Robert forwarded on to me. I like the train one. Talk about a close call. Enjoy this one. Advertisements


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Khidr Khan was the Governor of Multan under Firoz Shah Tughlaq. When Timur invaded India, Khizr Khan, a Sayyid, from Multan joined him. Timur appointed him the Governor of Multan and Lahore. He then conquered the city of Delhi and started the rule of the Sayyid Dynasty in 1414 CE.
Sayyid Dynasty was the fourth dynasty of the Delhi Sultanate, ruling from 1414 to 1451 CE. The rulers of this dynasty claimed to belong to the family of Sayyids or the descendants of the Prophet Muhammad, through his daughter Fatima and son-in-law and cousin Ali, who belonged to the Banu Hashim Clan of the Quraish Tribe.
This gold tanka issued by him was sold for INR 65,000 by Todywalla Auction held in Mumbai on 19th April 2014. The obverse of this coin is inscribed as 'Al-Sultan Al-Azam Abul Muhamid Muhammad Shah Bin Firuz Shah Sultani'. The reverse of this coin is inscribed as 'Fi Zaman Al-Imam Amir Al-Muminin Khulidat Khilafatuhu'.
Image Courtesy: Todywalla Auction


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It's Friday, so...
Ampersand Design Studio
Get away from the computer, get outside, and by all means, have a drink :)
We have been working our little buns off redesigning our site & blog this week, so needless to say, we are so ready to let loose!
H A P P Y F R I D A Y, everyone!!
-morgan & carrie


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Learning to Thrive in 1455 has gotten a facelift… and a new name!
Head on over to anaspiringheroine.com to see what all the fuss is about, and thanks for following along during this initial part of my blog journey!
– Tyler
Learning to Thrive in 1455 has gotten a facelift… and a new name!
Head on over to anaspiringheroine.com to see what all the fuss is about, and thanks for following along during this initial part of my blog journey!
– Tyler
Impromptu date night, that's what!
Last week was rough, you guys. I thought having Monday off would make it fly by, but I was oh so wrong. Spencer and I both had really long work days, and by the time we got back from the gym (because I still haven't chickened out of my fitness goal for the year!), all we wanted to do was heat up leftovers and sit mindlessly in front of the TV. Certainly not the most romantic thing in the world.
As we were lifting on Thursday because I lift weights now, I asked Spencer what he wanted for dinner and hoped that he would say "Hot dogs and baked beans sound great to me!" (If you follow me on Instagram, you've probably seen the hot dog toaster that my college roommate gifted us when we first moved into the apartment. She meant it as a semi-joke, but it has made an already simple meal choice even easier!)
Luckily for me, he had other plans. Continue reading
Warning: This post will contain spoilers if you haven't finished Edith Wharton's novel, The Age of Innocence. Give it a read and come back! We'll wait.
Hello, fellow bibliophiles! I am so excited to get to write this first post for Book Club Classics. I thought about starting this book club for months before I had the nerve to actually throw it out to you all, and now I can't believe it's actually happening!
If you don't know what I'm talking about, you can read all about this new book club. Also, if you haven't read my introduction to Edith Wharton and her Pulitzer Prize-winning novel, you should pop over and then come back here!
Now, let's dive in, shall we? Continue reading
Hello, friends! Wednesday marks the beginning of Book Club Classics with Edith Wharton's novel The Age of Innocence. I thought it might be nice to have a bit of an introduction to the book, and I also have tons of random questions that I kept track of while reading the book, and I'd love to hear your thoughts on them. Oh, and there may be a little surprise at the end. I guess you'll have to read and see for yourself! Continue reading
Since you don't exactly get another chance at having a perfect wedding (or at least the goal is to not…), I figured I would share with you all of the things that I would do differently if I could just convince Spencer that having a wedding 2.0 would be super fun instead of the most stressful and irrelevant thing imaginable. Hindsight is 20/20, am I right? Continue reading


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Nobody pulls a bigger rabbit out of a smaller hat than Steve Jobs. Apple's CEO stuns the computer world yet again with a long-planned switch to Intel chips, dumping IBM's PowerPC chips by 2007. Really, truth is much stranger than fiction.
Many of the prognosticators appear to be correct. Very correct. Dvorak. Thurrott. The Wall Street Journal. They got right what Apple Insider and Think Secrect did not. Apple is switching from IBM's speedy, powerful, and incredibly HOT PowerPC chips, to a new breed of chip manufactured by half the Wintel juggernaut, to go Intel Inside.
Macs with Intel chips? Yes, Virginia, it's true.
Steve Jobs announced the culmination of a secret five-year plan to make sure Mac OS X could run on both IBM's PowerPC chips and Intel's dominant chip architecture. The next step is a two year plan to put Mac OS X and thousands of applications on new Macs. Macs with Intel chips inside.
The "Intel Inside" secret has been announced numerous times in recent years, particularly as IBM failed to produce chips at speeds, quantities, and sufficiently cool to handle Apple's requirements. In recent months, the rumors began circulating again.
Then, in recent weeks and days, a small chorus of "Intel Inside Macs" began. Dvorak. Thurrott. cNet. WSJ. Jobs' stunning announcement at Apple's World Wide Developers Conference in San Francisco brought down the house.
Why? Steve said Apple wants to build the best computers for their customers and Intel wants to build the best chips. No mention of IBM's PowerPC efforts, though it's obvious that Apple is more than miffed that IBM couldn't reach the 3ghz level promised a year ago.
Apple and Intel can't be happy that Microsoft chose IBM's PowerPC architecture for the upcoming Xbox360. As did Sony for the new PlayStation. That made Apple a small player in the PowerPC chip world.
So, Apple moves from IBM chips to Intel chips. Intel Inside. What's the world coming to?
At the WWDC announcement, Steve brought in Paul Otellini, Intel's CEO. What did Paul do? He played the famous "Bunny" TV commercial where Apple set fire to Intel's old Bunny mascot. The crowd loved it.
Otellini even called Apple the "most innovative computer company in the world." The crowd cheered.
Also on stage was Adobe CEO Bruce Chizen who said Adobe wouldn't exist if it were not for Apple. Roz Ho, the Mac Business Unit General Manager for Microsoft, said they've been working with Apple and plan to have the universal binaries available to support Mac OS X applications on both Intel and PowerPC chips.
How easy will it be for Mac developers to port their applications to the new Intel chips on Macs? Theo Grey of Wolfram Research, the makers of the complex application, Mathematica, was asked to come to Apple in secret and port Mathematica to the Intel version of Mac OS X.
He did in two hours.
Steve's demonstrations included working version of Photoshop, Quicken, Excel—all running on Mac OS X on a Mac with an Intel chip.
Stunned? Got questions? Yes, and more yes.
For example, when will all this happen? By 2007. Will Mac applications for PowerPC Macs run on the new Intel machines? The answer is "yes" by using a special emulation layer called "Rosetta," after the Rosetta Stone.
What's the next version of Mac OS X to be called? Leopard. My preference is "SaberTooth" but I guess it's not to be. Oh, Leopard will show up at the end of 2006, early 2007. That's about the same time as Microsoft's Longhorn is scheduled to debut.
Sometime in the next 18 months you can expect to see new Macs shipping with Intel chips inside. Developers will now be required to port their applications to a new universal binary so Mac apps can run on both PowerPC and Intel Macs.
If you're like me, you have a lot LOT more questions that don't have answers. Cheaper Macs? Mac OS X running on non-Apple Intel boxes? Will Mac apps run faster than current Macs? You get the idea.
Oh, one more thing. Yes, early this morning, hell froze over.


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Posted on August 21, 2018
Keeping our teams up to date and checking in on every individual within our business is essential in allowing us to grow, learn and develop our team in the right way. Our incredible Salon Managers have excellent interpersonal skills and we train and develop them to take care of their salon as their own, empowering them to make decisions and understand how to get the best out of their team members. Our Salon Managers very much lead by example for the whole team, carrying out beautiful hair services with the best customer service, dealing with any service issues or queries and managing the salon running's overall. Our Salon Managers keep our team on track with their personal and business goals and also reward excellence and outstanding team and customer care. Reflective of the level of expertise and dedication, our Managers salaries reflect their effort and hard work and passion.
Putney Salon & Spa | Battersea Salon


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- Wedding Wednesday
through a bit of a life change at the moment. I don't do well with crying puppies in crates. Michael told me to put Bokeh in his crate and go up to my office and just blast the music so I can't hear him sobbing. ugh. It's a miserable feeling but I HAVE to get some things done, even though it's my off season! There are some things that I could accomplish now and they would REALLY save me some time for this upcoming 2012 wedding season. The list is long but I'm working hard at it!! Normally, on Wednesdays when I feel rushed or I have too much to do, I blog about something interesting… but EASY.
I don't have time today to setup a CocaCola Tablescape or re-decorate my mantle….. but I DO have time to talk about DRESSES! The "Dress" is such a HUGE part of the wedding day. Some girls grow up DREAMING about the perfect dress they want… for me, I didn't have a CLUE! When I went into the bridal boutique, this lady asked me if I wanted a "mermaid fit" or more of a "fit n' flare" or an "A line" style dress…. umm… I had NO IDEA what I was looking for! There were so many options!! I knew I didn't want a BALL GOWN but I was a little overwhelmed with my other options. Thankfully, I tried my dress FIRST!! That's right, the first dress I tried on, I bought…. it was a quick process. However, I WISH I had kept dress shopping a little bit more just for FUN! I could have tried on some glamourous dresses but I didn't, I found what I liked and I just wanted to pay for it and mark that off the list. I wish I had enjoyed that process a little longer.
There is so much that goes into not only picking a dress, but SHOPPING for one also. Here are some OVERALL dress tips for all of you engaged gals out there! :
1. Make a day of it. Decide to devote one Saturday to "dress shopping" and invite the mommas! If you're close to your future mother-in-law… she would probably love to be there too! It's a fun day for the girls and it's a great time to help parents feel included and a part of the planning process! If it gets overwhelming, just stop and find a Starbucks:)
2. Call ahead and make an appointment. A lot of newly engaged brides don't realize that you can't just want into a dress shop and try on whatever you see… you have to make an appointment to stand in front of that mirror and be oohhed and ahhhhed at:)
3. Try styles that you didn't originally think you would necessarily like!! You may be surprised and it never hurts to TRY!
4. Go with your GUT!…. But don't totally disregard others opinions. Say you LOVE a dress but your mom can already tell that you're going to be pulling it up on it CONSTANTLY… you can talk about getting it altered to fit more snuggly around the bust and waist… or maybe that style isn't the best for you. I've deleted a TON of reception images of Brides tugging on their dress, trying to keep it up while they're getting their groove on! You don't want to worry about that on your wedding day.
5. Don't give up! If you're on round 3 or 4 of dress shopping… it's OK. You will find one!!! Just keep going! I've heard of brides finding their DREAM dress on their 6th trip to the boutique!!
6. Know the difference between White and Ivory dresses. It used to be weird for a bride to have an off-white dress. I am kind of glad that tradition is fading away because pure white dresses do not photograph as well as off-white dresses. My wedding dress was off-white but you can HARDLY tell. Sometimes pure white dresses photograph with a "blue" tint to them because they are SO white. Thankfully I can adjust my "blues" in my post processing to correct this for the most part.:) Having just a slightly off white dress can really make a HUGE difference in your images AND it's so flattering for the skin! A white dress symbolizes the "purity" of the bride and since Michael and I waited until marriage… I totally understand how powerful that symbol is! However, I also know that I'm a REDHEAD with the fairest complexion known to MAN… so my "candlelight white" dress helped me not look like a GHOST! ha!
7. Pick a dress that you're COMFORTABLE in. If you feel like you're poured into it an can't really get a "full" breath…. you can't buy that dress. Imagine getting nervous on the wedding day and trying to get some deep breaths to calm down…. but you can't, because your wedding dress doesn't fit correctly! ah! Not good! In June, before my wedding, I tried on my gown and it was tight… like REALLY tight! I could breath but I knew that I wouldn't be COMFORTABLE if had to wear this thing all day. So I hit the GYM…. HARD. By 10.10.10 it was perfect. I could breathe easily, sit down, hug people and dance without showing anything inappropriate and without suffocating!:)
8. Don't be afraid to ALTER a dress. I've seen SO many cool things be added to dresses! It can look so natural and unique! You can also take away pieces of the dress. Say you LOVE a dress with a sweetheart neckline but it has one over-the-shoulder strap… welp, just have a seamstress take that strap off! Make your dress your own! Add fun ACCESSORIES if you want! Veils, broaches, beaded vintage sashes… I love it all!! I'm such a girl.
9. Make sure your MOH or momma is with you for your final dress fitting…. someone NEEDS to know how to bustle that thing! I've had bustles take over 30 minutes sometimes either because of operator error or something BREAKING. So make sure your planner has some safety pins just in case! (Also, having some emergency "white chalk" can cover up any minor stains on the dress…. I learned that from my friend Anna... she's on top of things!)
10. Enjoy this process….this is supposed to be FUN!!! Stop worrying about impressing others and enjoy shopping for the gown of YOUR dreams!!
My dress was the first or second I tried on, too! I wish I'd drawn the process out a bit more though- I loved my dress, but I think I might have chosen something a little more unique if I'd taken the time to visit more than just a David's Bridal. But I'm married now and that's all tha treally matters :)
All very true!! Funny, I talked about dresses today too! And I have to comment on the joys of having a puppy…mine is almost 4 and still doesn't like to let me do work. The only way I can get her to calm down some days is to break rules and let her on the couch or the bed or in my lap while I'm working so she can sleep and cuddle with me. Ridiculous! Be tough on yours so he doesn't end up spoiled rotten :)
My dress was the first one I tried on too! Although my mother and the lady at the bridal store didn't let me stop there… I think I tried on what felt like 50 dresses, and I still went back to the first one! :)
I feel the same way/had the same experience as Abby Grace! And I love shopping! I wish I'd had drawn out the process too!
I've been a silent follower of your blog for two years (I live in MN so it's fun to see what's going on in other parts of the country) and just got engaged. Your timing for this post is perfect, as my mom and future m-i-l are going shopping this weekend. Thanks!!! And congratulations on such an awesome business and website. I doubt we'll ever meet but I feel like I know you :-)
That is such a good tip for choosing your dress that an ivory dress photographs better! I will definitely be coming back to this post when I get engaged :)
So true!! Love all these points! Along with those safety pins, make sure there is a SEWING KIT around juuuust in case someone steps on your train and it rips a huge hole in the back. :)
I just went dress shopping in Paris with my best friend a month ago and it was so much fun!!! Makes me wanna get married too! Haha just need to find a guy, but I almost already know which dress I'll choose (a lace Monique Lhuillier gown!!!!) Thanks for your sweet comment today Katelyn!!! ;) I hope I'll get to hug you for it one day in person! <3
All of these are so great! Some of them I didn't really think about when I went shopping (like off white vs. pure white) but others I definitely had. And HOORAY for number 8 – altering – I fell in LOVE with a black belt from another dress but hated the dress, so we put the belt on mine! It's totally "me" and I can't wait to have something a little different!!


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Why didn't you tell me that proper etiquette and common courtesy did not apply while attending performances on base?
I recently took my mother-in-law and nine- year old to see, "The Christmas Carol" performed by students from East Carolina University at our base theater. The doors opened at 2 p.m. and the performance started one hour later. In all honesty, we were out by 4 p.m.
In my opinion, it was just right. The performers did an excellent job and the story did not seem rushed. Even better, these college kids did this for FREE, yes FREE! All of that practice and hard work to come to a military base on a weekend. It was a wonderful thing that they did, I was very grateful.
However, as they were performing, I was embarrassed and annoyed. How dare these other parents allow their children to run up and down the aisle, bounce on chairs, and use "outdoor voices" during a live performance?
Furthermore, how dare these parents with babies bring them to a loud performance and then continue to stay in the theater while the baby was screaming? Not only was this rude to everyone that worked to put this play on for us, but it was rude to everyone in the audience as well.
Now, before you think that I have well-behaved children (laughing hysterically here) let me tell you, I do not! There have been plenty of times that I have had to remove them from a public situation to save my sanity and their lives (just kidding about that part but it seemed like it at the time.)
Plenty of times we have had plans to attend an event and then based on their behavior at home we have not gone. We knew it would just be a disaster.
In addition to my nine-year-old, I also have a toddler. As you read above, I did not take her with me to the play. This was for the sake of myself and for the sake of everyone else.
I also know that children will not learn how to behave in a public setting if they are never put into one. That's where the parents need to be stepping in, teaching them to sit down and be quiet. If the child can't be quiet, then remove them from the performance (you know, that thing called consequences).
Better yet, if your child is not old enough or if you are not able to handle them -- dare I say it? -- Do not come to the performance and let everyone else enjoy the show.
Jessica Gardner is a Marine wife currently residing in New Bern, NC. She told us, "My husband call's me a, "control freak" where as I prefer to use the term, "control enthusiast." There I go again, trying to control how he describes me! I'm a very proud Marine Corps wife with a love/hate relationship regarding the Marine Corps. I am also blessed to be the mom to two girl's ages 9 and 3 who I love dearly.


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Event box
Accessibility Conference Make-a-thon: STEM.
Description: The Accessibility Conference is pleased to co-host* its first make-a-thon workshops! Two three-hour accessibility-focused workshops will take place on Monday, May 27, 2019. Conference attendees and campus members are welcome to attend - no experience required! Please note, there are only 25 spots available for each session.
Learning Outcomes
During these workshops, you will be able to:
- Learn about the maker movement and creative process by participating in a guided make-a-thon
- Explore the intersection between the maker movement and inclusive design
- Undertake a maker challenge based on the real needs of post-secondary students with disabilities
- Find out about maker groups and events in your community
Special Guests
- Stewart Russell - Regional Coordinator, Makers Making Change (Central Canada)
- Mahadeo Sukhai - Head of Research and Chief Accessibility Officer, Canadian National Institute for the Blind
Make-a-Thon Workshop Themes
- 9 a.m. to noon - reading and writing accessibility
- 1 to 4 p.m. - STEM (Science, Technology, Engineering and Mathematics) accessibility issues
It's fun, it's free and you can win prizes! Don't buy that equipment - make it!
*Brought to you by the McLaughlin Library , the THINC Lab and the University of Guelph Accessibility Conference.
Session Level: All welcome – no experience required.
Materials: Laptops helpful but not required.
Fee: Free!
- Date:
- Monday, May 27, 2019
- Time:
- 1:00pm - 4:00pm
- Location:
- Scholars Studio Room 289
- Campus:
- McLaughlin Library
- Categories:
- Event
Registration has closed.


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Mutant HABP2 Causes Non-Medullary Thyroid Cancer
Modeling of mutant (blue) and wildtype (pink) HABP2 (534 position indicated in yellow) showed that the glutamate substitution changed the protein's structure disrupting the active site and substrate accessibility.
The thyroid is a butterfly-shaped gland that lies at the base of the throat in front of the windpipe. A member of the endocrine system, the thyroid secretes hormones to regulate heart rate, blood pressure, temperature, and metabolism. Cancer of the thyroid is the most common endocrine cancer and the eighth most common cancer in the U.S. An estimated 63,450 Americans will be diagnosed with thyroid cancer this year. The vast majority is of follicular cell origin, and the remaining cancer originates from parafollicular cells, so called medullary thyroid cancer.
Familial non-medullary thyroid cancer (FNMTC) accounts for three to nine percent of thyroid cancer cases and has a dominant inheritance pattern. FNMTC can be syndromic, meaning it is associated with additional cancers and known susceptibility genes, or nonsyndromic, where it is the only cancer. Most FNMTCs are nonsyndromic. These cancers are clinically defined by the presence of thyroid cancer in two or more first-degree relatives in the absence of other predisposing or environmental factors and are more aggressive than sporadic thyroid cancer. Because a number of candidate chromosome sites and genes have been reported, FNMTC development may be due to multiple different alterations.
To further investigate the genetic landscape of FNMTC, Electron Kebebew, M.D., Chief of CCR's Endocrine Oncology Branch (EOB), and his colleagues have a clinical protocol in which kindreds with more than 200 family members have undergone evaluations. Sudheer Kumar Gara, Ph.D., a Postdoctoral Fellow in the EOB, has been investigating one of the largest kindreds and performed high-throughput DNA sequencing on blood samples from family members with FNMTC. At the time of the initial evaluation, three family members had thyroid cancer. Screening ultrasound identified thyroid neoplasms in four more members, and two of eight individuals in the youngest generation had abnormal ultrasounds showing small thyroid nodules. One affected family member had a previously-removed atypical mole, but none had a history of other primary malignancies, and the researchers detected no other benign tumors, supporting a classification of nonsyndromic FNMTC.
Comparing the DNA sequence from affected family members and unaffected spouses, the investigators identified two single-site variants present only in the affected members. One variant in the HABP2 gene was found in all seven affected family members and resulted in an amino acid change from glycine to glutamate at position 534 (G534E), which is located in a highly-conserved protease domain. Modeling the structure of the protease domain revealed that the glutamate substitution disrupted the enzyme active site and prevented substrate access.
When the scientists examined HABP2 expression in the familial cases, they found high levels of HABP2 protein in the tumors but none in normal thyroid tissue. HABP2 mRNA levels mirrored protein expression in these samples. In contrast, only 25 percent of 12 sporadic thyroid cancers showed any HABP2 expression. The increased expression of the G534E variant in the affected family members' tumors suggested it was potentially pathogenic but was less common in sporadic cases of thyroid cancer.
By further sequencing the HABP2 coding regions, the researchers found that the variant was heterozygous in germline and tumor DNA. They failed to identify additional changes in the HABP2 coding sequence; HABP2 copy number variations; somatic mutations in BRAF, KRAS, NRAS, or RET oncogenes; or other known rearrangements, suggesting the HABP2 variant functions alone in FNMTC. Analysis of The Cancer Genome Atlas (TCGA) database revealed that up to six percent of cancers have somatic mutations in HABP2.
The investigators next asked what effect normal and variant HABP2 had on cell behavior. Loss of HABP2 increased colony formation and cell migration, suggesting it might act as a tumor suppressor. In support of this idea, overexpression of HABP2 reduced both colony numbers and migration. In contrast, overexpressing the G534E variant enhanced colony formation, increased cell migration, and promoted the formation of foci, all hallmarks of cancer. Expressing equal amounts of normal HABP2 and the G534E variant in the same cells still led to increased numbers of foci, indicating that the variant has a dominant-negative effect on the tumor suppressor function of normal HABP2. The scientists also looked at data for 423 patients with papillary thyroid cancer in TCGA's database and found that nearly five percent carried the G534E HABP2 variant compared to 0.7 percent in population databases where disease status is not known.
Together, these results indicate that HABP2 is a susceptibility gene for FNMTC that can promote cancer on its own. The G534E variant was found in all affected family members, was expressed in thyroid tumor but not normal tissue, and inhibited normal HABP2 tumor suppressor function in cell studies. Future studies will need to address whether HABP2 can play a similar role in other types of cancer, how exactly the G534E variant participates in cancer initiation and progression, and the clinical implications for carriers of the variant in the family studied here as well as in the general population.Summary Posted: Sat, 08/01/2015
Gara SK, Jia L, Merino MJ, Agarwal SK, Zhang L, Cam M, Patel D, Kebebew E. Germline HABP2 Mutation Causing Familial Non-Medullary Thyroid Cancer. NEJM. July 30, 2015 PubMed Link


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Menorah Lights Shine Brightly in Lewis Park
Story Kristina Hoti
A crowd gathered in Lewis Park in the Village of Warwick on Sun., Dec. 2, for the Menorah lighting at sunset, to celebrate the first night of Hanukkah. Warwick residents and local business owners, Moshe and Doris Schwartzberg, and their daughter, Sarah Carew, organized and sponsored the event.
Although overcast, the night was mild and the rain held off as guests joked to Schwartzberg saying, "You are here in all types of weather- rain or shine!"
Warwick Mayor Michael Newhard and Town Supervisor Michael Sweeton were in attendance as well. During the event, Schwartzberg told the story of Hanukkah and the Maccabees, who in 168 BC defended their faith against Antiochus Epiphanes IV, who outlawed the Jewish faith, and whose armies desecrated their temple.
Schwartzberg gave a blessing of the Menorah, in both English and Hebrew, and said the Shehecheyanu blessing, which is said on the first night of Hanukkah. At sunset, just a few minutes before 5 p.m., Schwartzberg lit the shamash, which is the center candle of the Menorah, and that from which the others are lit. The first candle was then lit, and the festive crowd walked to Schwartzberg's restaurant, Wolfie's, where the room had been cleared and set for a party.
Latkes, donuts, and apple cider were served at Wolfie's, along with chocolate gelt and plastic dreidels for the children. While getting ready to light the Menorah inside Wolfie's with actual candles, Schwartzberg talked of how it takes a surprising number of candles to keep the Menorah lights burning for the eight nights of Hanukkah.
There are many reasons for the custom of giving gelt (money) at Hanukkah, one of which is the Talmud's statement that if the poor cannot afford to buy both Hanukkah candles and their ceremonial kiddush wine, the candles must take precedence. Giving gelt ensured that the poor had the money needed for candles.
Today, chocolate gelt wrapped in shiny gold foil is enjoyed by children at many Hanukkah celebrations, and the party at Wolflie's was no exception. The children enjoyed their sweets and dreidel toys.


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Mosaic Tapestry
Date: January 19-20, 2019 | Time: 10:00 am - 4:00 pm
Location: Fuller Craft Museum, 455 Oak Street, Brockton, MA
Cost: $180 Museum Members / $240 Nonmembers
Class Size: Minimum 4/Maximum 8 registrants
Materials Fee: $30 per person (paid to instructor on first day of class)
Register for the Workshop on Eventbrite.com
In this hands-on workshop, you'll learn how to combine simple and complex patterns to create a mosaic tapestry or carpet. You will make a 5" X 10" tapestry by creating intricate designs using millefiori, glass, jewelry, fabric and beads. Design templates will be provided. No grouting required. Open to students at all levels. This class is open to students at all levels.


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Faculty Positions in Westlake University∣March 23rd, 2019
- Employer
- Westlake University
- Location
- Hangzhou, Zhejiang (CN)
- Salary
- Salary Negotiable
- Posted
- January 09 2019
- Discipline
- Life Sciences, Physical Sciences, Chemistry, Computer Sciences, Electrical/Electronic Engineering, Engineering, Information Technology, Materials Science, Mathematics, Nanotechnology, Physics, Renewable Energy, Other
- Position Type
- Full Time
- Organization Type
- Academia
- Job Type
- Faculty
Review of applications will start upon receipt and will continue until the positions are filled. To guarantee full consideration, the application should be received by February 10th, 2019. Successful candidates will be shortlisted for the talents interview scheduled on March 23rd, 2019.
Westlake University seeks exceptional scholars in all branches of cutting-edge science and technology from around the world. As an international university, Westlake University encourages qualified applicants from all ethnic background and from all countries. If you believe you are among the best in your chosen research field, you may wish to consider a career opportunity in Westlake University.
- Faculty Positions are open at four distinct ranks: Assistant Professor, Associate Professor, Full Professor, and Chair Professor.
- Each faculty member will receive an internationally competitive salary and a fringe benefits package that includes a generous housing option, a high-end medical care plan for the entire family, etc. These benefits have been designed with references to those of the elite private universities in the US.
- Each faculty member is provided with an internationally competitive start-up package that includes sufficient research funds, ample laboratory space, excellent equipment and research support. Stable financial support safeguards every research project that is designed to push the envelope of human knowledge.
- The research disciplines include, but are not limited to, chemistry, all major branches of engineering, life sciences, mathematics, physics, and inter-disciplinary fields. The engineering disciplines include, but are not limited to, electrical engineering, computer science, information technology, energy and environment, nanotechnology and material science, and emerging technology. Westlake University emphasizes inter-disciplinary research.
In addition to the specifications listed above, Westlake University also has a number of advantages that are rarely found elsewhere. First, due to the small size of Westlake University, inter-disciplinary research collaboration is truly spontaneous and becomes part of a daily routine. The faculty members from different disciplines bump into each other at the coffee shop, student cafeteria, faculty club, and seminar rooms. Second, all faculty members hired in the first several years of university development will have stories of their own to recount how they not only witnessed but also contributed to the breathtaking rise of a brand-new university, the first new-type research university in the history of China. These fond memories constitute a once-in-a-lifetime experience for any scientist with a dream at heart. Third, due to the small size of the faculty, your opinion truly counts within the university. The sense of "my university" is considerably stronger here at Westlake than elsewhere. In addition, administration serves, rather than directs, research and teaching here at Westlake. This scholar-friendly environment is part of the Westlake culture on campus.
Please send the application documents as electronic PDF files to firstname.lastname@example.com
- Curriculum Vitae - Your most recently updated C.V. including a publication list
- Cover Letter
- Statement of Research Summary and Research Proposal (3-5 pages)
- 3 letters of reference required (sent directly to the above email address)
YANG Mengchen, Office of Human Resources, Westlake University
Address: 18 Shilongshan Road, Cloud Town, Xihu District, Hangzhou, Zhejiang Province, China
For more information, please visit: http://www.wias.org.cn/english-flist-426.html


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Jordan Clayton, Freelance UX/Creative Director
Fei is a remarkable person to work with. Her diligent work ethic, organization skills, and collaborative nature make her essential for any team she's on. She knows how to take a complex project from beginning to end with as little turbulence as possible. I've personally experienced multiple accounts where projects were becoming too unclear or disorganized and Fei swooped in to tame the confusion and drive us forward. Above all, her passion is contagious and will be sorely missed.


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The Department of Environmental Management (DEM) has formally withdrawn its Draft Environmental Assessment for a proposed composting facility in Pana'ewa amid residents' concerns that the location of the facility would impose adverse impacts on the community. This location for the facility was specifically identified in the Compost Contract.
DEM Director Bill Kucharski withdrew the documents in an April 4, 2017, letter to the State Department of Health's Office of Environmental Quality Control.
"The Proposing Agency, the County of Hawai'i Department of Environmental Management, Solid Waste Division, has withdrawn the (Draft Environmental Assessment) published on September 8, 2016 due to concerns that the location of the proposed facility could impose additional impacts on the local communities, many of whom claim a disproportionate share of undesirable land uses," Kucharski's letter said.
The letter also withdrew an Anticipated Finding of No Significant Impact for the proposed facility.
In the letter, Kucharski noted that the proposed East Hawai'i Organics Facility was intended to divert organic waste such as green waste, food waste, paper and compostable material from Hawai'i County's landfills.
The facility's aim was to generate compost from mulch and food wastes to support agriculture and homeowners.
Withdrawal of the document puts an end to the concerns of the local community about the location of the proposed compost facility at the Hilo landfill site. While The EA was held pending since the December 2016 meeting between Mayor Kim and the local community, the formal withdrawal of the EA closes this chapter. The County will be pursuing new locations and is in the process of renegotiating the composting contract to allow for alternate locations.
For further information, please call Bill Kucharski at DEM at (808) 217-2750.


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Wolfgang's Steakhouse sponsors Kia Women's Open
Wolfang's Steak House Korea said Friday it is sponsoring the Kia Motors 32nd Korea Women's open through offering gourmet meals for its guests. The restaurant said it offered a special lunch package ...
Sharing taste of modern Singapore with Seoul
[Around the Hotels] Promotions and Packages
Summer afternoon tea at Sheraton Seoul Sheraton Seoul D Cube City Hotel's Lobby Lounge Bar presents a new afternoon tea set for the summer season. The afternoon tea set, served in a uniquely tiered...
[Home Cooking] Slow cooker spicy braised pork ribs (maeun dweji galbijjim)
Korean braised dishes are so easy to cook in the slow cooker, and this spicy braised pork rib (maeun dweji galbijjim) is no exception! You throw the ingredients in the slow cooker and forget about it...
[Epicurean Challenge] Raw anchovies softly tickle the throat
Anchovies come in all shapes and sizes, ranging from 1 to 15 centimeters. In Korea, they are cooked in different ways according to their size. Some end up as myeolchihoe, or sliced anchovy served ra...
Jun 14, 2018Food&Beverage
[Around the Hotels] Promotions and packages
Cozy night with children at Conrad Seoul Welcoming family guests with children, Conrad Seoul presents a new children-friendly package. The kid-oriented package includes a night stay and a breakfast ...
Jun 8, 2018Food&Beverage
Jun 8, 2018Food&Beverage
[Epicurean Challenge] Satisfying sweet tooth with red beans, patbingsu
In the sweltering heat of summer, patbingsu, or shaved iced with red beans, is a popular treat. The most classic type of bingsu, which refers to desserts made of shaved ice and condensed milk comple...
Jun 7, 2018Food&Beverage
[Video] Five iced drinks to quench summer thirst
Summer has suddenly arrived in Korea after an untimely wet and humid May. Temperatures soared up to 31 degrees Celsius Friday, prompting many Koreans to either head outdoors to enjoy the sun or indo...
Jun 5, 2018Food&Beverage
[Around the Hotels] Promotions and packages
Taste of Singapore at Millennium Seoul Hilton Millennium Seoul Hilton's all-day-dining buffet restaurant Cafe 395, will introduce Singaporean cuisine from June 12-19. The restaurant has invited two...
Jun 1, 2018Food&Beverage
[Home Cooking] Jeonbokjuk (abalone porridge)
Porridge made with abalone (jeonbokjuk) is one of the most iconic dishes of Jeju island. It's deliciously briny, with a distinct greenish hue and chunky abalone pieces. The Jeju-style jeonbokjuk is ...
Jun 1, 2018Food&Beverage
[Epicurean Challenge] Figuring out cow's anatomy, yangdaechang
Cows are very giving creatures, producing milk, butter, cheese, beef and more. But in Korea, they are extra-giving, as the cartilage from the bones and knees are also eaten. Adding more to the list, ...
May 31, 2018Food&Beverage
Pizzeria specializes in small-batch specials, unconventional and classic pies
May 26, 2018Food&Beverage
Ocean view buffet at Hotel Tops 10 Hotel Tops 10's all day dining buffet restaurant Poseidon offers a gourmet experience with quality at a reasonable price. High-end dishes, such as smoked salmon, ...
May 25, 2018Food&Beverage
[Video] 'Creamart' takes latte art to a whole new level
Barista Lee reveals secret of his success in Seoul via interview
May 25, 2018Food&Beverage


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Mornin', Ole,
Ole and Lena went to the same Lutheran Church. Lena went every Sunday and taught Sunday School. Ole went on Christmas and Easter, and maybe a few times during the year.
One Sunday, Ole was sitting in the pew right behind Lena and got to noticing what a fine looking woman she was. While they were taking up the collection, Ole leaned forward and said, "Lena, how about you and me go to dinner in New Ulm next Friday?"
"Yah, Ole, dot vould be nice," Lena replied.
Ole was tickled as all get out. All week long he polished his old Ford truck. On Friday he picked up Lena and took her to the finest restaurant in New Ulm.
When they sat down, Ole looked at Lena and asked, "Lena, vould you a cocktail before supper?"
"Oh, no, Ole," Lena said, "Vat vould I tell my Sunday School class?"
Ole was a little taken back, but he didn't say much about it. After dinner, he reached in his pocket and pulled out a pack of cigarettes, offering Lena one.
"Oh, no, Ole," Lena said, "Vat vould I tell my Sunday School class?"
Well, Ole was feeling kind of low, having had two offers rebuffed. On the way home, was they passed the Hot Springs Motel, he figured, heck, he'd struck out twice, so he had nothing to lose.
"Hey, Lena, vould you like to stop at the motel with me?"
"Yah, Ole, dot vould be nice," she replied.
Ole couldn't believe his luck. He whipped his Ford into the parking lot, jumped out of the truck, ran into the hotel office, checked in, ran back out, and took Lena right to the hotel room.
The next morning Ole got up first. He looked at Lena lying on the bed, her hair spread out all over the pillow. "Vat have I done, vat have I done?" Ole thought. He shook Lena awake. "Lena, I've got to ask you von thing."
"Vot's dat?" she said, sleepily.
"Vat are you going to tell your Sunday School class?"
"The same ting I alvays tell dem. You don't have to drink and smoke to have a good time."
Notice displayed on a plane:
There is no smoking in the cabin on this flight. There is also no smoking in the lavatories. If we see smoke coming from the lavatories, we will assume you are on fire and put you out. This is a free service we provide.
There are two smoking sections on this flight, one outside each wing exit.
We do have a movie in the smoking sections tonight … hold on, let me check what it is … Oh here it is; the movie tonight is Gone with the Wind.
Q: Why was Michael Jackson kicked out of the Boy Scouts?
A: He was up to two packs a day.
Rabbit Yarn
A rabbit one day managed to break free from the testing laboratory where he had been born and brought up. As he scurried away from the fencing of the compound, he felt grass under his little feet and saw the dawn breaking for the first time in his life. 'Wow, this is great,' he thought.
It wasn't long before he came to a hedge and, after squeezing under it he saw a wonderful sight, lots of other bunny rabbits, all free and nibbling at the lush grass. 'Hey,' he called. 'I'm a rabbit from the laboratory and I've just escaped. Are you wild rabbits? 'Yes. Come and join us,' they cried. Our friend hopped over to them and started eating the grass. It tasted so good.
'What else do you wild rabbits do?' he asked. 'Well,' one of them said. 'You see that field there? It's got carrots growing in it. We dig them up and eat them.' This, he couldn't resist and he spent the next hour eating the most succulent carrots. They were wonderful.
Later, he asked them again, 'What else do you do?' 'You see that field there? It's got lettuce growing in it. We eat them as well.' The lettuce tasted just as good and he returned a while later completely full. 'Is there anything else you guys do?' he asked.
One of the other rabbits came a bit closer to him and spoke softly. 'There's one other thing you must try. You see those rabbits there,' he said, pointing to the far corner of the field. 'They're girl rabbits. We shag them. Go and try it.' Well, our friend spent the rest of the morning shagging his little heart out until, completely knackered, he staggered back over to the guys. 'That was fantastic,' he panted.
'So are you going to live with us then?' one of them asked.
'I'm sorry, I had a great time but I can't.'
The wild rabbits all stared at him, a bit surprised. 'Why? We thought you liked it here.'
'I do,' our friend replied. 'But I must get back to the laboratory. I'm dying for a cigarette.'
What's the result of smoking too much?


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Ruth: Piano Teacher in Walthamstow, E17, London
Our piano teacher, Ruth, in Walthamstow offers classical piano lessons for ages 3 and above, from beginner to advanced (up to a Grade 8 standard). She has a Bachelor of Music from Goldsmiths and a Master of Philosophy in Musicology from Cambridge University, and has been teaching piano lessons since 2004, privately, in schools, and as lecturer at the university level. This piano teacher's professional career, focused on opera and musical theater, has included roles as artistic director, producer, and librettist, with prominent organizations such as the London Symphony Orchestra. She has also been a music writer for Classical Magazine and radio co-producer and presenter for More than Mozart. Her high level of artistry on the piano combined with her wide-ranging professional experience offers a broad perspective on the music industry and creative practice, delivering engaging piano lessons that inspire students to release their creativity and express themselves through the piano.
Request Lessons with our Piano Teacher in Walthamstow, E17
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Soane was preceded at Port Eliot by Humphry Repton who produced one of his Red Books for Port Eliot in 1792. He argued strongly for linking the church with the house. An idea not taken up by Soane. His initial design was for a new west front that would open on to an axis ending at the east end of the house. This would have involved the demolition of the old gallery wing and Lord Eliot would not permit this so that, in the end, Soane's work was, except for minor changes to windows, largely internal. The enfilade, the finishing of the circular drawing room and of the eating room, the re-design of the library, new stairs and top lighting were among Soane's achievements.
Other works done for the Eliot family are: alterations to Down Ampney, Gloucestershire, 1799 (q.v.) and alterations to 33 St James's Square, London 1805 (q.v.).
Jill Lever
March 2016
P.Beacham and N.Pevsner, 'Cornwall', 2014, pp.542-9
Sir John Soane's collection includes some 30,000 architectural, design and topographical drawings which is a very important resource for scholars worldwide. His was the first architect's collection to attempt to preserve the best in design for the architectural profession in the future, and it did so by assembling as exemplars surviving drawings by great Renaissance masters and by the leading architects in Britain in the 17th and 18th centuries and his near contemporaries such as Sir William Chambers, Robert Adam and George Dance the Younger. These drawings sit side by side with 9,000 drawings in Soane's own hand or those of the pupils in his office, covering his early work as a student, his time in Italy and the drawings produced in the course of his architectural practice from 1780 until the 1830s.
Browse (via the vertical menu to the left) and search results for Drawings include a mixture of Concise catalogue records – drawn from an outline list of the collection – and fuller records where drawings have been catalogued in more detail (an ongoing process).
Contents of Port Eliot, St German's, Cornwall: remodelling of interior and designs for new stables for 2nd Lord Eliot, 1804-6 (97 )
- Sketch survey drawings, September 1804 (46)
- Survey drawings, October 1804 (9)
- Designs for alterations, November 1804 (8 )
- Perspective designs for house and church (4)
- Working drawings for stairs, March 1805 (5)
- Designs and working drawings for fitting out library and circular drawinng room, 1805 (7)
- Designs and working drawings for fitting out library and drawing room, 1806 (8 )
- Designs for stables


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Understand your sample's purity and concentration
For scientists working with DNA, RNA, or proteins, sample quality often plays a critical role in determining the success or failure of an experiment.
The Thermo Scientific NanoDrop One UV-Vis Spectrophotometer and the Invitrogen Qubit 4 Fluorometer, when used together, provide the ability to obtain the most complete information about the concentration and quality of your DNA, RNA, or protein sample. Knowing the precise concentration and purity of your sample early helps you prevent costly troubleshooting and rework downstream.
Get complete sample intelligence in seconds.
Quantitation—Comparing Qubit fluorometer to the Nanodrop One UV/Vis absorbance
The best of both worlds — the combination of the NanoDrop One UV-Vis Spectrophotometer and the Qubit 4 Fluorometer enables accurate, easy, and fast quantitation of biomolecules.
Which instrument do I need?
For workflows that involve nucleic acids, determining the concentration (quantity) and purity (quality) of the sample is often a necessary step. Ultimately, the more you know about your sample up front, the lower your potential risk of experimental failure later.
While both the NanoDrop One Spectrophotometer and Qubit 4 Fluorometer offer accurate measurement of DNA, RNA, and protein samples, each also has unique advantages.
Cited in more than 30,000 publications, NanoDrop UV-Vis microvolume spectrophotometers fundamentally changed the way scientists evaluate nucleic acid and protein samples by eliminating the need for large sample volumes.
The next-generation NanoDrop One microvolume spectrophotometer utilizes Thermo Scientific Acclaro sample intelligence technology, which identifies contaminants, provides corrected concentration values, and helps you assess the quality of your sample before you use it in downstream applications.
The Qubit 4 Fluorometer is a cutting-edge benchtop device that accurately measures DNA, RNA, protein quantity and RNA integrity, and quality using the highly sensitive Invitrogen Qubit assays.
In conjunction with state-of the-art, highly optimized algorithms and a seamless user interface, the Qubit 4 Fluorometer employs fluorescent dyes that only produce signal when bound to the target of interest, thereby minimizing the effects of contaminants— including degraded DNA or RNA—on your results.
Instrument comparison
|NanoDrop One Spectrophotometer
|Qubit 4 Fluorometer
Fast and simple—allows direct measurement of purified samples with no dilutions required
Sensitive and specific—measures nucleic acid concentration accurately whether dsDNA, ssDNA, total RNA, or microRNA, even in the presence of contaminants. With the RNA IQ assay, Qubit 4 is able to measure intact or large RNA from degraded or small RNA in 5 minutes.
|UV absorbance
|Pipette sample onto pedestal; measure
|Mix sample with reagents, incubate for 2-5 minutes, read.
|Routine assessment of quantity and quality (purity) of DNA, RNA, and proteins
Use with very dilute or difficult-to-process samples, when higher sensitivity is required or when nucleic acid contaminants are suspected (e.g., DNA in RNA; presence of dNTPs). Also use for rapid assessment of RNA integrity and quality.
|dsDNA quantification range (ng/μL)
|0.2*– 27,500
|Sample quality assessment (purity)
Acclaro sample intelligence technology identifies presence of contaminants such as protein or guanidine; provides corrected analyte concentration value
dsDNA sample contaminated with protein. The absorbance contribution from the protein (orange) is subtracted from the original result (blue) to obtain the corrected dsDNA concentration (green).
Unique fluorescent dyes enable differentiation between sample types, including nucleic acids (e.g., DNA vs. RNA), without any sample pretreatment.
The Qubit dsDNA HS Assay is selective for dsDNA, even in the presence of an equal mass of RNA.
* dsDNA quantitation range for NanoDrop One is 0.2 ng/μL with cuvette and 2.0 ng/μL without.
For samples that are 100% pure and made of a single nucleic acid type (e.g., dsDNA), the results obtained on the NanoDrop One Spectrophotometer and the Qubit 4 Fluorometer would be expected to be identical for samples within the instruments' dynamic ranges. However, few samples are 100% pure.
For most labs working with nucleic acids, it is highly advantageous to have the speed and flexibility of the NanoDrop One Spectrophotometer along with the specificity and sensitivity of the Qubit 4 Fluorometer. Together, the two elegantly designed instruments provide you with precise quantification and intelligent quality assessment of your biomolecule of interest, and help save your lab significant time and money by helping to prevent downstream experimental failures.
Quantitating nucleic acids: downstream applications guide
|NanoDrop One Spectrophotometer
|Qubit 4 Fluorometer
|General PCR
|Routine PCR applications have become robust over the years. Using UV to quantify the template is sufficient.
|Good for routine samples, preferred if sample is prone to high amounts of contaminants that absorb at 260 nm (A260) (dNTPs, oligos, RNA, etc.).
|Quantitative PCR
|UV allows the researcher to determine the presence of contaminants that may affect the polymerase reaction (e.g., phenol).
|Reliable qPCR results require highly accurate template concentrations. The specificity and sensitivity of Qubit assays are well suited for this task.
|Using UV to quantify the template is sufficient, except if the sample is prone to high amounts of contaminants that absorb at 260 nm (A260) (e.g., RNA in DNA samples).
|If samples are prone to contaminants that absorb at 260 nm (A260), the high specificity of a Qubit assay is advantageous.
|Next-generation sequencing
|UV for sample evaluation during the library construction process. Allows the researcher to determine presence of contaminants that may affect different stages of the workflow.
|Reliable NGS results require highly accurate template concentrations. The specificity and sensitivity of Qubit assays are well suited for this task.
|Standard RNA extractions are less prone to DNA contamination, so UV measurement can be used to normalize the amount of RNA that goes into the reaction.
|The specificity and sensitivity of Qubit assays are good for routine samples, and desirable if the sample is prone to DNA contamination or degraded RNA (dNTPs and NTPs).
|QC of dye-labeled microarray probes
|Enables simultaneous measurement of the amount of dye and probe.
|Not recommended for QC of dye-labeled microarray probes, but Qubit assays can be used to accurately measure microarray probe concentration.
|Genotyping / mutation detection
|A260 measurement can overstate concentrations due to mixed contaminants.
|Samples often contain contaminants that absorb at 260 nm (A260), making the specificity of the Qubit assay desirable.
Quantitating proteins
|NanoDrop One Spectrophotometer
|Qubit 4 Fluorometer
Selection of preprogrammed applications
Total protein concentration for three samples shown as red squares on a BCA assay standard curve (top panel); four different purified protein samples were measured using the Protein A280 application (bottom panel).
|Qubit assays exhibit minimal protein-to-protein variability and are resistant to most contaminants, including salts, reducing agents (DTT, β-mercaptoethanol), DNA, and amino acids, but not detergents.
Low protein-to-protein variation in the Qubit protein assay. Solutions of the following proteins were assayed: bovine serum albumin (BSA), chicken egg ovalbumin, chicken egg lysozyme, bovine milk β-casein, equine myoglobin, bovine milk α-casein, porcine pepsin, mouse immunoglobulin (IgG), and calf thymus histone.
UV-Vis and Vis Spectrophotometry
Meet your analytical challenges with our complete line of ultraviolet-visible (UV-Vis) spectrophotometers. Our award-winning designs and user-friendly software help you quantify, assess purity, and more.
Fluorometers and Fluorescence
Use fluorometers to quantify, detect and monitor analytes and their reactions by measuring the intensity of the fluorescent signal from dyes attached to biological molecules as well as naturally fluorescent molecules based on signature excitation (Ex) and emission (Em) wavelengths.
Ordering information
Request a quote or demo
NanoDrop One Spectrophotometer and Qubit 4 Fluorometer
For scientists working with DNA, RNA, or proteins, sample quality can play a critical role in determining the success or failure of an experiment. Together, the NanoDrop One UV-Vis spectrophotometer and the Qubit 4 fluorometer provide your lab with the ability to obtain the most complete information about the concentration and quality from your DNA, RNA, or protein sample.
To request a quote or demo for one or both devices, complete our form and a technical specialist will contact you to make arrangements.
Qubit assays
Nucleic Acid Quantification Support Center
Find tips, troubleshooting help, and resources for your nucleic acid quantification workflow.
For Research Use Only. Not for use in diagnostic procedures.


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Summertime is grilling time! Is grilling one of the healthiest ways to cook?
Summertime is grilling time! Grilling is one of the healthiest ways to cook. Think beyond burgers and hotdogs: Grilling adds rich, smoky flavors to many foods without adding a lot of fat and calories. With a few simple tips, you can cook an entire delicious, healthy meal on the grill, including dessert.
You don't have to give up eating beef just because you are watching your cholesterol. Opt for lean cuts of beef like flank steak, filet mignon or top loin. When shopping, remember loin = lean. Lean cuts of pork and lamb are good grilling options too. Trim all visible fat before cooking.
"By creating your own marinades, you can control the flavor, calories and sodium," said Casey Potts, registered dietitian, Norton Weight Management Services. "It's fun to experiment with different herbs and spices for new flavors you can't get in the store."
Potts recommends making your own marinade for chicken by starting with a drizzle of olive oil in a zip-close plastic bag. Add fresh-squeezed lemon or lime juice as well as the rind. Citrus juice helps tenderize meat, and the oils from the rind add a blast of flavor. Next add several dashes of your favorite herbs and seasonings, like Italian, rosemary, dill or Cajun. The possibilities are endless! Oil it up. Lean foods tend to stick when placed on a hot, dry rack. Oil your hot grill rack with a canola oil soaked paper towel held with tongs. Do not use cooking spray on a hot grill.
Don't forget the veggies. Fire-roasted vegetables have a unique, irresistible flavor. Place smaller, cut veggies on foil to grill.
You don't have to skip dessert. "The natural sugars in fruits will caramelize on a warm grill, creating a sweet but good for- you dessert," Potts said. "Try grilling pineapple rings or peach halves, then drizzle with honey and a dollop of low-fat vanilla yogurt for a satisfying summer treat."
Also look for Carlos' Homestyle Bar-B-Que Sauce, a secret recipe sauce perfect for grilling, in local stores. Proceeds help support Norton Children's Hospital. To find retail locations, go to HelpNortonChildrensHospital.com.


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Betty Tompkins
Galerie Andrea Caratsch, S4
In 1969 Betty Tompkins started painting her first group of monumental, photorealistic and detailed images of sexual intercourse. Since then, Tompkins' unashamed approach to female desire and sexually explicit imagery have informed her main body of work, qualifying her as a key protagonist in the development of a liberated feminist discourse.
Galerie Andrea Caratsch presents two of the historical 'Fuck Paintings' – the series of nine works painted between 1969 and 1974 – together with an important rubber stamp work, and two later paintings inspired by Courbet's The Origin of the World (1866). Tompkins' photorealistic black-and-white scenes, cropped and enlarged from pornographic magazines, remain as shocking today as they were when they were created. Rejected at the time not only by prudish institutions and the male-dominated art world, but also by the mainstream feminist movement – which regarded pornography as a vulgar extension of patriarchy – Tompkins' work has been marginalized for more than 30 years. Only recently, art critics and museum shows have helped to establish the ground-breaking role of Tompkins's practice in representing sexually explicit imagery from a woman's perspective, thus reversing the monopoly of the male gaze.
Betty Tompkins (Born 1945, Washington; lives and works in New York) Betty Tompkins moved to New York in 1969. Her earliest group of paintings, made between 1969 and 1974, were shown for the first time in 2002 at the Mitchell Algus Gallery in New York. Tompkins' work was shown at the Lyon Biennale in 2003, following which her first intercourse painting Fuck Painting #1 entered the collection of the Centre Pompidou – Musée National d'Art Moderne, Paris. Most recently the artist's paintings have been included in 'Black Sheep Feminism: the Art of Sexual Politics' (2016) at Dallas Contemporary, curated by Alison M. Gingeras.


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Earth-Honoring Dance: Isadora Duncan and the Creative force of Pleasure
November 20 2-5 pm. Led by Laura Melling
"Exuberance is beauty." -- William Blake
Dance, in its ancient expression, was practiced not as a form of entertainment, or exercise or catharsis. Throughout most of human history, dance was a path toward connection with the animals, plants, fairies, stones, angels, spirits, fields and waters that sustained our lives. Following this ancient way we discover that, when given space to expand into its natural state of ample connection, the body springs to life, full of pleasure and creative exuberance. Concentrating our attention on the body's capacity to connect to other-than-human realms, we begin to restore dance to its ancient roots... ...And discovering this expanded state of the body, we begin also to remember how to fully love the Earth.
Why Isadora?
Often called the 'mother of modern dance', Isadora pioneered radical, still largely neglected, reconsiderations in Western thinking about the Body, facilitating a remembrance of the connection between the Earth and Body-Wisdom. Because Isadora's work cannot be summed up as a set of ideas or concepts, her somatic practices remain generally incomprehensible to our mind-dominated mass culture. Rediscovering the somatic foundation of our connection to the vitality of Nature is the first step in restoration of organic pleasure.
Isadora's work can not be summed up as a set of ideas. The only way to comprehend her vision for the future is to engage in the somatic practices that led Isadora herself to re-discover her body's genuine senses of pleasure and Earth-connection.
Come join the loving band of dancers worldwide who have kept these incredible teachings alive for the past 100 years. Beginners Welcome. This practice is completely unlike any other existing movement training. Your own life experience is all you need to begin a practice in this method.
Pleasure & Creativity:
These workshops will teach theories, images & practices oriented toward the enhancement of these aspects of somatic creativity:
-Instinct: The subconscious psyche and somatic process are unified at the level of instinct. Pleasure, dreams, intuition, healthy aggression, sexuality, creativity, security, grounding and spirituality all share a single physical, instinctual source.
-Revelation: Direct connections to the voice of the Earth, to our dreams and our unconscious process, are necessary for the soul and spirit to participate joyfully in our daily life and decision-making.
-Ease: The body-soul finds its true center when held within an affirming, safe, group dynamic honoring the somatic foundation of life. The natural state of the body-soul is pleasurable ease.
-Ritual: Dance as a collective symbolic process strengthens the body-soul's ability to embrace light and darkness, cruelty and beauty, grandiosity and poverty as acceptable states of being. A person's capacity to affirm his or her own somatic experience as a source of creative inspiration is often vastly improved by participation in formal group movement.
Workshops will include: Bioenergetics (a 100+ year-old method for shaking open the nervous system) for stress release/grounding/physical renewal, Isadora Duncan's techniques & theory & work with relevant Mythology.
Register: By writing or calling firstname.lastname@example.com or (303) 918-6183.
Fee: $40-60 sliding scale/ each workshop. Scholarships available to those who work as providers of holistic or artistic education for children and in service to the preservation of the environment.
Laura Melling, MA, IDMA, is one of a handful of teachers worldwide certified to teach the theory and movement of Isadora Duncan. Her work as a teacher and performer has received support from the National Arts Council of Ireland, the Isadora Duncan International Institute, and the state of New Jersey, among others. She has performed and presented throughout the US, and in France, Ireland, Ecuador, and many sites around Greece.
Isadora Duncan's dance is an invitation to:
-Align the Lower body with the Earth and its rhythms and align the Upper body with the Sky and its melodies.
-Align the Solar Plexus with the Horizon.
-Align to the Movement harmonies alive in Nature.
-Cultivate the Inner body temple and bring it outward into Earthly form.
-Cultivate a dynamic relationship between inward Repose and outward Expression.
Duncan dance is different from folk, ballet, contemporary and free-form dance practices, in that:
-Duncan training avoids defining the body or dance by reference to mental concepts. Duncan dance utilizes the body's own language -- somatic experience -- to address the body.
-Duncan classes avoid empty repetition of movement exercise. Duncan practices instead cultivate a sense of meaning and vision within movement, from the first class and onward.
-Duncan training, while involving extensive improvisation, moves beyond free-form, cathartic definitions of dance. Duncan practices cultivate attention toward the nourishing energies brought to life through intentional creation of movement form.
Isadora's method offers natural structures that support the body's deep desire for intimate, repeatable, dynamic communion with the Earth and its energies. Come get carried away!


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Who Are We?
Lifebuilders Kids is a fun and safe place for children to learn more about Jesus and how to follow Him with all their hearts, mind and strength. Our leaders are committed to valuing and developing each child's relationship with God and others through our weekly lessons which might include songs, crafts, teaching time, sharing time, Bible reading and the use of relevant and appropriate media resources. All our Teachers and Helpers have a current Working with Children Check (Blue Cards).
At Lifebuilders Church, we have three programs for our children each Sunday when kids are dismissed from the service after worship.
Afrikaans Service @ 8:00am for our kids that can speak bilingually in English and Afrikaans.
English Service @ 10:00am which consists of a Junior program and a Senior program.
The first week of each month is a Combined Service where we all come together to learn and build friendships.
Junior Kids
For children aged 1 to Grade 3 and we are currently learning about God's Amazing Animals and Big Bible Stories by Gospel Light.
Senior Kids
For children in Grade 4, 5 and 6 and we are currently investigating the truth behind the life of Jesus using 'The Case for Christ' by Lee Strobel.
School Holidays
During the school holidays, we invite the children to come and enjoy a kid-friendly movie or sit in church with their parents.
Our Check-In Process
Check-in for each service is at the sign in desk which happens during the service. Using Electronic Check-in, we now offer added security to help keep our precious kids safe. A leader at the desk will check your children in with any important medical information, and a label will be printed for each of your children and for yourself. Please attach this to your child and keep the other one for yourself in a safe and easy to access place. The label contains a security code for each of your children and will be used to call on you during the service if you need to attend to your child.
You will also need your label to pick up your children at the end of the service.


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Blog Entry #15: Writing Advice-Motivation #3, Beginnings/
If you're at that point where motivation isn't a problem, if you're sitting down and actually working on your writing, that's a good sign. But there's another issue that can come up after your research and worldbuilding, after you've poured yourself a cup of coffee or opened an energy drink or taken a swallow of whiskey. The beginning of your story.
For some people, writing the beginning of the story is part of the problem linked to motivation. They have the entire thing (or most of it) in their head, playing like a movie. You see your heroes and your villains duking it out, you have a few quotes in your head, and you've outlined a few pivotal scenes (or at least thought about them). So you sit down to right, and nothing comes out. Not because of a lack of motivation, but because starting the story—just writing the opening sentence or paragraph—is suddenly daunting. Why is this? You know what your story is. You know that you want to get going. But the intimidation and anxiety caused by the opening sentence, paragraph, or pages is just nagging you. So you quit your word document and watch Netflix or go to sleep.
Okay take a deep breath. There are a few ways to alleviate the issue of beginning. One is, to pretend like the rest of your story doesn't exist. Just do this for a moment. Stop thinking about how boring the opening is and refuse the urge to info dump (as we all want to do). Those things will come in time. Write an opening hook, then develop something at the beginning. Pretend the first few pages or the first chapter is a short story. Allow it to be a seed, then germinate. Let it grow from there.
Another way to handle it is to skip the beginning, at least for a time. On at least two novels I've written I didn't write the beginning until I had finished my entire first draft. Sometimes you don't even think of what the beginning should be until you've fleshed out the rest of the story. You don't have to start in the middle or anything like that, but start writing one of the scenes you like, and if it becomes what you want, build on it, either toward the future or the past. Write a chapter before it, write a chapter after it. Sort of like the 'Ignore it' rule, you can jump from one important chapter to the next, and then worry about fleshing out those other chapters later. This way you are actually writing, which is what you want.
To get over the anxiety of motivation you often have to destroy the idea of perfection. For many of us, we want to make it big. Or, you just want to impress the people reading your work. Or, you want to write something that's worth talking about. And you think that if it isn't perfect out of the gate, it's not worth it. The secret is: no author in the history of time has written a perfect first draft. It just doesn't happen. There doesn't have to be rewriting, but there is always fidgeting and fiddling. Neil Gaiman himself said he often detests looking at his own past works because he can find a problem on every page, and Brian K. Vaughan doesn't like to read his own works because he can't stand his own writing. These are people who have made it, and have been working on their craft for years. So you don't have to worry about perfection, you just have to worry about putting the words on the page.
Sigh. Beginnings. It's about half motivation and half anxiety of imperfection. I'm sure there's many other ideas and faults wrapped around beginnings as well. But they don't have to be terrifying, they can be fun. Cut yourself some slack and do something strange, if you can't think of how to write what you wanted to write. Kill someone early. Write an outburst. Make some sort of decisive, strange action to pull the action along. Your delete key is right there, so play around a little. You might find that your story turns into something entirely different than what you first thought.


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Olive Flower Essence ~ revive
Olive Flower Essence ~ revive
Olea europaea) ~ revive
Olive flower essence is for when you feel exhausted even though you have rested. For when you have abused your body and would like to regain your vitality. To help access your energy reserves when you are flagging and are not able to rest.
~Have you had an illness that has left you feeling exhausted ?
~Are you feeling weak and shaky for no apparent reason ?
~Do you have fluctuating energy levels?
"Olive trees teach us that however old and tired we are, however much grief and hardship we have had in our lives we can always find the energy to send out new growth and new shoots and be even more fruitful than ever before. All we need to remember is to dig deep and remember the joy and energy that Spring unfailingly brings .
As a flower essence Olive is very useful to use after a long hard winter or after illness to bring a spring back into our step." Saskia on Instagram


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BEIJING, CHINA - AUGUST 2011: The recently-renovated Beijing Planning Exhibition Hall is located in Qianmen Dongdajie, Chongwen District, just east of the old Qianmen Railway Station. Its four floors provide a comprehensive overview of Beijing's storied past and a brave vision of its promising future. In addition to conventional display cases and photographs, the exhibitions include light boxes, sculptures, and a highly detailed scale model of the city. Most notable, however, is the 3D multimedia auditorium on the top floor, which features one of the world's largest 3D screens. When the auditorium's audio processor had to be replaced, A/V integrator Sanecore Group installed a new Symetrix Jupiter "zero learning curve" digital signal processor.
The 3D multimedia auditorium comfortably seats two hundred visitors in a space of four-hundred square meters (4,300 square feet). The room is purpose-built to multitask. In addition to
showing a 3D movie about Beijing, the room regularly shows feature films (both 3D and 2D) and provides a forum for conferences. Three Barco Galaxy projectors provide crisp, precise imaging. The room's sound system is as impressive as it is flexible and features a full 5.1 surround sound system for a compelling 3D experience. When the 5.8 meter by 20 meter screen was installed in 2007, it was the largest 3D screen in the world. The city simulation movies that were created for the exhibition hall take visitors through the city, both old and new, in a way that is educational and entertaining.
"The original processor, which was not a Symetrix by the way, stopped working on November 3, 2010," said Alan Ho, design specialist with Sanecore Group. "I know the exact date because replacing the unit was so time-sensitive as it brought everything to a screeching halt. Together with the staff at the Exhibition Center, we decided to replace it with a Symetrix Jupiter 8." Because Sanecore Group is China's premier pro audio and lighting distributor and A/V designer/installer, it has been responsible for many of the country's most ambitious A/V systems.
Jupiter's allure was its promise of "zero learning curve." Borrowing the obviously successful "app" paradigm from smartphone technology, Symetrix engineered the Jupiter hardware to take on a multitude of audio processing tasks via application-specific software apps. Users select an appropriate app using the intuitive App Finder utility at Symetrix.co and upload it to the Jupiter hardware. In an instant, the Jupiter hardware is perfectly configured for the task at hand, and a plug 'n play computer interface makes tweaking the audio simple. The 3D multimedia auditorium uses the Sound Reinforcement #9 App, which provides matrix mixing, equalization, and speaker management.
"We were very pleased to use the new Jupiter system," said Ho. "The physical installation was quick, and the entire system was tuned in under an hour. In contrast to the prior processor, the Jupiter is infinitely flexible, and we were able to choose an app that would satisfy all of the demands of the 3D theater. Changing the default settings was easy in the elegant Windows GUI that is provided." In addition to replacing the processor, the Jupiter also replaced an analog equalizer and other miscellaneous analog technologies.
The three current flavors of Jupiter hardware, Jupiter 4, Jupiter 8, and Jupiter 12, differ only in their input and output counts. Jupiter 8, with eight inputs and eight outputs, was well matched for the 3D multimedia auditorium. A Soundcraft GB8-32 delivers eight output groups to the Jupiter 8, which in turn provides signal to a modest rack of QSC ISA amplifiers. An EAW sb184C subwoofer complements a surround array composed of Renkus-Heinz PNX full-range loudspeakers.
"Because the Jupiter replaced not only the failed processor, but also a number of analog processors, the signal chain shortened considerably," noted Ho. "Previously, the system connections were complicated and the sound quality suffered as a result, both in terms of fidelity and noise. The new Jupiter-based system is much cleaner, owing in part to the transparent sound quality of the Jupiter hardware and software and in part to the simplified signal chain. It's crystal clear and stunning. There is no distortion."
Reliability was also a critical factor in the choice of a new processor. After all, the operators of the 3D multimedia auditorium had just experienced how quickly things can grind to a halt in the absence of a functioning audio processor! "A failure reflects poorly on the city," explained Ho. "The Exhibition Hall is located on the southeast side of Tiananmen Square, one of the most attractive sites for both national and international tourists. The exhibits and the 3D movie are educational not only for visitors to the city, but also for the residents of the city itself.
"The staff at the auditorium gave very high praise to the Jupiter system," concluded Ho.
ABOUT SYMETRIX Sound professionals rely upon the performance, value and reliability of audio mixing, routing and processing products from Symetrix. For more information on Symetrix professional audio products, please visit www.symetrix.co or call +1.425.778.7728.


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Blank Error Message on Horizon View Administrator Console following upgrade to Horizon v7.x/
Following an upgrade from Horizon View v6 to v7 the administrator console was no longer accessible from my laptop but when logged into the Connection Server the URL https://localhost/admin worked fine.
The behaviour is caused by a new security feature in Horizon that if the URL of the View Administration page does not match that of the Secure Tunnel URL or is https://localhost/admin.
Since a lot of the time I use different URL's to the Secure Tunnel URL for different things this has proved to be quite a nuisance so I have disabled this new behaviour of View by altering the SSL gateway locked.properties file:
1. On each Connection Server create a text file called locked.properties in C:\Program Files\VMware\VMware View\Server\sslgateway\conf
2. Open the file in a plain text editor.
3. Add this line:
4. Save and close the text file.
5. Restart the View Connection Server service.
Now when connecting to the View Administrator the correct login prompt should be displayed.
Please refer to the VMware KB article for further details:


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First Pictures Of Tiwa Savage In Her Beautiful Wedding Gown!
Tiwa's wedding in being held in Dubai today,Don't you love her wedding gown, She looks soo beautiful! Her makeup was done by Joyce Jacob Beauty, she is wearing Vera Wang. The pictures were taken by Alakija Studios, and the whole event was planned by Prive Events – Elohor Aisien.


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Brussels is a great city, but you have to know it before you discover all her hidden and amazing secrets. This is a particular historical place, every corner reminds of a bit of its long history.
Centre of Brussels, the great place and its surroundings, less known places but still very interesting, good places to take pictures, le Sablon and its surroundings, typical pubs.
Photographer with more than 20 years of experience, I Iove to share my knowledge in photography and in cities I like. Full profile ⋅ Leave a Review
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Jobless Numbers Are Worse Than You Think
The situation is much more dire now than it was during the 1980s.
In terms of employment, how bad is this recession? Last month's unemployment rate was 9.5%, according to the Bureau of Labor Statistics (BLS). But the jobs picture is even worse than that rate suggests.
The BLS defines the jobless rate as the number of unemployed as a fraction of the labor force. If one person in a labor force of 10 people is unemployed, the unemployment rate is 10%.


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What happened in my marriage?
It is always sad to say goodbye to someone you have shared your life with intimately.
Allow your heart to remain open to say goodbye powerfully with grace and power. There is no need to allow bitterness to overcome you. My ex and I said goodbye in a great way.


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Of principle importance to the duteous legal practitioner is the abstention from granting preference to esoteric terminology at the expense of concise transmission of the perceived reality.
In other words, lawyers shouldn't let their choice of words get in the way of their arguments. Year after year, this issue confronts law school grads entering the real world and flexing their legal muscles. Baby lawyers—and many seasoned ones—view their degrees as a license, if not an imperative, to churn out hollow chestnuts such as "here and before," "heretofore," and "notwithstanding," like it's their job—as it frequently is. And while this may lead to an excellent boost in Scrabble scores, it's also a somewhat neophytic (pardon, prithee, the egregious slander) approach to legal writing.Read More


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NEW YORK (CBS.MW) --Sithe Energies Inc, the U.S.energy group controlled by France's Vivendi SA, said Monday it's selling 21 power plants to Reliant Energy for roughly $2.1 billion and is forming an Internet energy company in partnership with Vivendi and Japan's Softbank.
U.S.-listed shares of Reliant Energy
The 21 power plants -- which total 4,276 net megawatts of generating capacity -- include 16 in Pennsylvania, four in New Jersey and one in Maryland.
Separately, Sithe and Vivendi said they're forming an Internet energy company named K Road Ventures, which will initially focus on business to business services. K Road Ventures will be jointly owned by Sithe, Vivendi, the Sithe management and Softbank Corp. of Japan.
Sithe's chairman, president and chief executive officer (CEO) William Kriegel, will also become CEO of K Road Ventures. "We intend for K Road Ventures to capitalize on the numerous opportunities that are created by the continued deregulation of the utility industry, coupled with the increasingly important role of the Internet," Kriegel said in a statement.
In Paris trading shares of Vivendi vvdiy declined 2.3 euros, or 1.92 percent, to 117.2, while in the U.S. Friday, Reliant Energy REI, +0.88% fell 1/8 to 21 3/16.


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A WordPress Autoblog video selected by www.Free-Mail.co.za:
How to use autoblog Clickbank with CB Goliath WordPress plugin.
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If you want to know more about my tips, guide and secret techniques.
Just visit me on my site:
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Visit the MyPE YouTube Channel.


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Fortunately, since we have a caveman at the helm, the president does not write the budget – Congress does. The president can submit his proposal, his request or wish list, but at the end of the day, it is Congress who writes the budget. Thankfully.
This week, Trump gave his wish list to Congress, and as we all suspected, it is atrocious. In short, he wants to take as much as he can possibly take from We the People and give as much as he possibly can to his wealthy cronies, raising the already-staggering deficit in the process. Let's take a look at some of the most egregious items, shall we?
- First, there is "the wall". Since he couldn't bully Congress into giving him the $5.7 billion he asked for to start work on the wall, he is now asking for $8.6 billion! And this guy is supposed to be a master dealmaker? The art of compromise is entirely lost on him!
- Then there is the environment. His proposal is to cut funding for the Environmental Protection Agency (EPA) by 31%. It would cut the EPA's Global Change Research office, which exists to provide scientific information to policymakers about the threats posed by climate change, as well as a number of other programs involving clean water and air.
- Along similar lines, he proposes massive cuts to the Department of Energy's (DOE) renewable energy and energy efficiency budget … some 70%!!! The Office of Energy Efficiency and Renewable Energy, which falls under the DOE, provides hundreds of millions of dollars a year in grants and other financial assistance for clean energy, has financed research into technologies ranging from electric vehicles to energy projects powered by ocean waves. It has been credited with financing research to help make the cost of wind power competitive with coal, and cutting the costs of LED lighting.
Note that Trump has repeatedly vowed to zero out federal spending on clean energy research and development, while doing everything in his power to promote and even subsidize the fossil fuel industry. The only conclusion that can be drawn is that either he truly desires the destruction of the human race, or he is really that damn stupid.
- He proposes to cut safety net programs such as food stamps, Medicaid, and housing assistance, all programs that low-income families depend on for their very survival. In spite of inflation, he proposes to freeze the maximum Pell Grant for low-income college students.
- He has also proposed to cut Medicare … that benefit that we all paid into every single paycheck of our lives … by $845 billion over the next ten years! And … he plans to cut $25 billion from Social Security … again, a program that we all paid 6.2% of our gross pay into every paycheck we ever earned in our entire lives!
Note that in 2016, when he was still a wanna-be, he said, "I'm not going to cut Social Security, like every other Republican, and I'm not going to cut Medicare or Medicaid." More damn lies!
- He also proposes to cut the Department of Housing and Urban Development by 16 percent and the Education Department by 12 percent.
- He does, however, wish to increase the defense budget by $750 billion (that's in addition to the $8.6 billion for his damn wall).
No part of the plan addresses increasing revenue, and in fact it extends the tax cuts for the wealthy that were passed in December 2017. It is by no means a balanced budget, and will absolutely, without question add to the national debt and deficit, both of which are already out of control, by trillions of dollars. What happened, I would ask, to those fiscal hawks that put Obama down for eight years for not balancing the budget, for deficit spending? Yo! Republicans! Can y'all hear me out there in la-la land??? This 'man' you all think so much of, that you're willing to lose friends over, is going to cut Social Security … the money you have saved for your retirement since the first day of your first job. Are you going to continue to sit on those fat, white posteriors and not even raise a stink?
But, there is good news. And that is …
Trump's budget proposal does not stand snowball's chance in hell of passing Congress! Not even a slight chance. Even the republicans don't like it! It is naught but his pie-in-the-sky wish list. However … what it does do is it speaks volumes about Mr. Trump's priorities, and his lack of concern for the people who put him into office. A president is elected, in theory, by the majority of the voters. In Trump's case, he was not elected by the majority at all, but was nearly three million votes short of it. One might think that would make him work a lot harder to win over those of us who did not vote for him, but instead, he devotes seemingly every waking moment to finding ways to stab us in the back.
We're tired of it. Instead of working with Congress to attempt to develop a budget that benefits the nation and its people, he is submitting a proposal that his own advisors have told him will not fly. He is working against the very people he swore to represent. His priorities are a wall, his rich cronies, his Star Wars-type toy, a 'Space Force', and other useless crap, for lack of a better word. Meanwhile, the poor and middle class, the 99% of the nation, will suffer if he gets his way. Those are his priorities, folks. His budget proposal tells us exactly where we stand … out in the cold.