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Getting out of the hobby. Please only PM me if interested in items for purchase as to keep my inbox less cluttered. You can also email me at firstname.lastname@example.com to inquire about items....... I will only accept US postal Money orders or PayPal plus their 4%fee. All prices will include shipping to the Continental US. If overseas please contact me for additional shipping.
All pipes below are used and smoke well, some need cleaning but all in good shape, ready to use.
1)Old Meerschaum pipe with brown stem, period look, bowl has a Minie ball shape to it. Has some engarving decorations around bowl. Shows a nice smoked patina. $45.00 shipped
2)Old Meerschaum pipe with almost black stem, period look, small carved bowl with engraved decorations. Shows a nice smoked patina. $35.00 shipped
3)Old Meerschaum pipe with almost marble like stem, period look, rectangular carved bowl with engraved decorations. Shows a nice smoked patina. Very Unique. $45.00 Shipped
4)Old Meerschaum pipe with brown like stem, period look, carved and decorated bowl design. Shows a nice smoke patina. $40.00 shipped.
5)Old Meerschaum pipe with black ornate stem, period look, oval shaped bowl with no engravings. Shows a nice smoked patina. $35.00 shipped
6)Old Meerschaum pipe with brown stem, period look, Minie shaped bowl with engraved floral designs. Shows a nice smoke patina. Very Unique. $45.00 shipped
7) Large Birch wood pipe with wooden stem and black bakelight mouthpiece. Period look. 15" overall length. This is a Man's Pipe! Big and Burly. Was not smoked very much. $45.00 shipped
Old Meerschaum pipe with a natural reed stem. period look, unique decorative carved bowl with flat bottom. Shows a nice smoked patina. Very Unique. $45.00 shipped
9) Saving the best for last! Old pipe, Briar wood bowl with silver metal accents, ash cover, curved bone stem and mouthpiece. A real fine pipe with a nice smoked patina. $55.00 Shipped
Pictures can be viewed here http://www.authentic-campaigner.com/forum/forum.php


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DOE Challenge Home Spotlight in Utah—Q&A with Bruce Hanson
Another proud recipient of a DOE Challenge Home Builder Award is Salt Lake City, Utah-based Garbett Homes. Their first Challenge Home, which they built in Herriman, Utah, won in the Production Builders category.
Their company averages between 18 and 22 employees who do construction, land acquisition and development, and office support. Garbett Homes currently builds 100% of their homes and apartments to an average HERS score of 34, and while this Challenge Home was their first venture into net zero, they are currently looking into building an entire 65-lot subdivision to that standard.
We wanted to know more about the award-winning home, so we spoke with Bruce Hanson, the energy director of the organization.
Q&A with Bruce Hanson
Home Energy: What was the biggest obstacle you faced when building your Challenge Home?
Bruce Hanson: Deciding if the buying market would be willing to pay the additional retail to get certified.
HE: I read that this home is the first DOE Challenge Home to be certified in Utah and the first net-zero home in the state—that's two huge accomplishments.
BH: We were the first DOE Challenge Home, but not the first net zero. We were the first net zero as a production builder, under $250 per square foot. The previous net zero properties in the state were over $250 per square foot and we delivered this net zero at $150 per square foot.
HE: Was net zero and building a highly efficient home goals for your company from the beginning?
BH: When we started our Energy Program about 4 years ago, it was a vague dream, but not until about a year ago or so did we think it might be viable.
HE: Are there occupants in this home now? If so, how is the home performing?
BH: Buyers aren't moving in until November 15, but it has been our sales office for the past three months. It has a lighter than usual load during nighttime hours but much higher loads during business hours. Currently it is producing more energy than is currently being used.
HE: Were there any systems used in the building of this new home that could be applied to retrofits on existing homes?
BH: It all depends on the extent of retro—if the retrofit is a major one, you could do 95% of the items. If it's a minor remodel, maybe just an upgraded furnace.
HE: How many homes do you build per year?
BH: We anticipate 400 units for 2013 and 500 units for 2014. All of our units are Energy Star certified.
HE: What is one piece of advice you'd give to other builders taking on similar projects?
BH: Unless you have a personal belief and goal to build a more efficient home, don't do it. The tighter you build your home, the more important it is to get everything right and working together. Just throwing a few items at the home can make the home perform worse. The home needs to be looked at as an entire machine and each component must work together, and be prepared to make mistakes and then correct those mistakes. It does cost more and sometimes much more, depending on home many mistakes need fixed. Study the hundreds of different ways to reach the score of zero and do what makes sense financially and for your market.
HE: What is your favorite room in your Challenge Home and why?
BH: I am a building science geek. The entire house is open and very appealing, but my focus is always the envelope of the home and mechanical room so that would be my favorite area.
HE: What do you think is the most important thing builders need to focus on in the next 5 years for home performance to become more mainstream?
BH: We need to get the buying public to understand the difference home performance makes in home construction. When the buyers demand it, it will happen. If left up to the builder, it will drag on forever.
You can read the full case study on this Challenge Home here.
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subset: commoncrawl


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Physiotherapy – what's it all about?November 9, 2009 at 3:03 pm | Posted in rheumatoid arthritis (RA) | 2 Comments
Tags: arthritis, doctor, exercise, flare, flare-up, hospital, neck pain, NHS, nurse practitioner, physical therapy, physio, physiotherapy, R.A., RA, rhematoid arthritis, rheumatoid, Rheumatoid arthritis, rheumatoid arthritis (RA), rheumatology
Wren posted a comment asking about physio and I thought it might get a bit long-winded for a comment answer, so I'm making a post out of it!
This was Wren's comment – sorry Wren, just realised that this answer is going to come a bit too late for your appointment! "On another subject: How often do you see your physio (physical therapist)? What do you do at the appointments? Are there special exercises? I'm curious because I keep reading of others having PTs they go to frequently, but this is something that I've never done, or even had suggested by my doc. I'm seeing him on Saturday morning, and I plan to ask about it, but in the meantime, how does this work for you?"
I personally see my physio every two weeks at the moment, but that's a timing that we decided between us and it's changed over the months I've been seeing her. I started seeing her weekly when things were really bad and we've moved on to two weekly. We tried three-weekly but that didn't work out – by the time I saw her after three weeks my shoulders were in agony!
There are indeed special exercises, but again they're entirely individual to each patient. I think it's fair to say that generally you don't do any exercises during a flare, reduced exercises during a "fizzle" (if you have fizzles, as I do!) and you try really hard to do them when things are fine, but frequently forget! Luckily I have a very understanding physio (this is afterall the woman who recommended a year's supply of cake, but she says I'm not allowed to post that story!!) and she appreciates that it's hard to remember to do the exercises when things are good!
What we do at the appointments is 1) Talk through how I've been over the last couple of weeks since I've seen her 2) Decide what needs doing this time 3) Do it. Usually, what needs doing is either ultrasound on my knee(s) or ultrasound on my neck and shoulder(s) or both. Again, I'm lucky to have such a flexible and understanding physio. By the time I got to see her, I'd been seeing another physio privately for months. Long story – see here and we'd established that ultrasound works for me. Again, it's a very personal thing. Some people find acupuncture fantastic, especially, apparently, for knees – I don't. Some people find ultrasound completely useless – I don't.
If there's a different joint giving me problems we'll talk through that and discuss if there are any exercises that might help, or whether ultrasound, TENS etc. might help.
I have a whole selection of exercises that I should do regularly for my neck, shoulders and knee, and a bunch of others to ease morning stiffness in other parts of me. The knee, neck and shoulder exercises are more to strengthen the muscles in those parts, so that they can do a better job of supporting the joints, rather than to actually do anything to the joints themselves.
The attitude of the nurse practitioners is 'use it or lose it', so the consensus seems to be that the more you exercise (within limits), the better. Not being the world's most active person the only time I'm likely to overdo those limits is when I'm having a flare (where minimal exercise is fine) or if I'm doing crochet, embroidery etc. and don't want to stop although my hands hurt!
I hope this helps explain the whole physiotherapy/physical therapy thing a bit, but it is, I stress again, only my own very personal viewpoint, and I know that every physio is different (because I've seen at least five over the years) and every patient is different. I reckon if you find a physio that suits you it can only help, so why not give it a try?
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Thanks for sharing more information on your physiotherapy routine. It was only this past year that I introduced PT into my bad of tools. I used to go 3x a week, and for the past couple of months have been going 2x a week.
My sessions usually revolve around electrotherapy (there are about 4 currents they use, in addition to TENS) and ultrasound. The also have a cold-laser machine that is particularly effective for the small joints in the fingers and hands.
Glad to hear that PT works for you as well. As with anything else it is not the one solution, but for me at least is has been great having it in the mix.
Comment by RA Guy— November 9, 2009 #
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Kris Humphries Wants $7 Million From Kim Kardashian to Go Away Quietly
The Hump is trying to get paid.
I see the strategy, but there might be a flaw in his plan. Before we get to that here are the details.
Kris Humphries is secretly demanding $7 MILLION from Kim Kardashian to walk away from their marriage … TMZ has learned.
Sources directly connected to Kris tell TMZ … the baller — through his Minnesota lawyer — has given Kim an ultimatum … either pay up, or endure an ugly, public trial.
Our sources say Kris and his lawyer have been told to pound sand.
The Hump is using the threat of an ugly divorce to try to get paid, but not understanding any publicity for the Kardashian's is good publicity.
Somehow they will turn the divorce proceedings into a money making venture and since Humphries signed that iron clad prenuptial agreement, he probably will be left out in the cold.
Could also try to leak more pics like the Playboy ones above.


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Bought 2 VLBows from LuisV this past week. I have bought items from him in the past without issue. Would buy from again.
Thumbs up to Luis!!!
Bought 2 VLBows from LuisV this past week. I have bought items from him in the past without issue. Would buy from again.
Thumbs up to Luis!!!
Level 10 Retro Mag
My Automags.Org feedback
My eBay feedback
I bought a Lapco barrel from Luis. It arrived well packaged and in perfect condition. Great communication too. I wouldn't hesitate to buy from him again.
Thanks, Luis!
Awesome guy, great price, fast shiping, perfect item! Thanks man!
I traded with him for a 12" JJ 2piece barrel. Amazingly smooth deal. Got the barrel extremely fast and we communicated well. Definately a man of his word, goes out of his way to please. Great guy, great deal, hope to deal with him in the future!
Proud EMAG Owner!
click here for my feedback
helped as a third party between me and PCI2000 and pretty much brokered our deal. great aoer. highly recommended.
The Arsenal:
-Xmag (Pewter) Sold!
-EmaX (Black) - Xvalve, ULE, Logic Trigger, 3.2 Software (PARTING OUT)
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Bought a barrel bag from LuisV. I didn't get it as quickly as I'd liked to have, but it got here just the same.
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AIM: Sharpcelica
AO Feedback
Bought tubing from me 2 times and was prompt on payment through both transactions. Thnaks Luis!
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AO PM: kilaueakid
He acted as a paypal third party for a transaction.
I paid him money by paypal. He then gave the money to another AO member to complete an online transaction. Very trustworthy. Very fast with service and communication. Professional.
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Feedback - AO
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Feedback - eBay
Paypal Verified Premier Member - 60+ Transactions
Exceptionally Good Traders: FunkTheManMunky, MRAirgunRT
Ask about my 3rd party trading services/prices
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That's how to ration the poor
Let them eat war [x2]
There's an urgent need to feed"
bought sear from LuisV, shipped on time and in exelent condition, will trade again.
Good Traders-Tobz,Blennidae,GhilleGuy,Snake847,jondon005,dzaide ,LuisV,CodeMA,Prezents,badinfo,B.C.,jeffremiller
I purchased an item from LuisV abot a month and a half to two months ago and it was never shipped to me. After two weeks of finally trying to contact him he finally returned my messages with a story that the item was lost and he would promptly send me a refund, that was two weeks ago and I never recieved my refund or the item. He is extremly difficult to get in contact with, has numerous excuses, and seems incredibly indifferent to whether or not I get the item or my refund. I would not deal with him again, ever. I will update this post when or if he ever resolves this complaint.
It came to a point in my life when it was either pay the rent or buy paintball gear. I think I made the wise choice. If anyoneone needs me I'm livin in a van down by the river.
My Feedback:
A smooth and a Professional transaction. Would buy from again, no problem. I couldn't be happier with the AO Shrink wrap tubing. Thanks again. - Eric
Great guy, stayed in touch and shipped very fast. A++++++++++++++
Picked up some AO-printed shrink tuning from him.. very smooth transaction. Item came quickly and I am very happy with it.
The world needs more like him.
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Palmer Typhoon
Double Blade Trigger
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Bought a pair of Kila detents from him and they were shipped to me right away. He is also responded quickly to all of my emails. Would gladly do business with him again.
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Ordered and got some heat shrink AO tubing. Great comm. and fast shipping. God Bless.
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bought a j&j barrel kit. item was shipped fast, and he communicated well. the barrel is in great condition, dont think there is a scratch on it! thanks again!
I bought the shrink wrap from him... Great buy, very reliable salesmen
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i bought some shrinkwrap and and kc oil. Great shipping and communication. A+++
I picked up some new warp parts from LuisV, nice guy to deal with. Treated me good and sent the items to me asap!
Got my Flydanna from him with some other things. Fast and courteous!


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ANDALE - The Orioles might have felt like they should've clinched the dual earlier than the final bout.
Either way, Augusta's wrestling team held off a spirited rally by Andale, ranked No. 3 in Class 4A. Jake Ehrlich won the heavyweight bout to seal a 37-32 win by the Orioles.
With the win, Augusta claimed the regular-season Ark Valley Chisholm Trail League Div. IV title by going undefeated in league duals. The Orioles finish the season 14-1 in dual competition, with their only loss coming to Kapaun at the Crusaders' home dual tournament. It's the third straight time Augusta defeated Andale in dual competition.
The Orioles started to take control of Thursday's dual as they've done so many times this season with their midweights. Connor Spellman (138 pounds) won with an impressive pin to kickstart a run by the Orioles, who 4 of the next 5 bouts, three of them with pins.
Wright Bosley (195) seemed to be continuing that streak that would've clinched the win for the Orioles. Bosley controlled most of the match and built a lead, but Andale's Derrick Yates squirmed loose from Bosley and got a pin in the final seconds to keep Andale's hopes alive.
Andale's Trever Buckner (220) also found himself down the entire match to Chance Runnion until Buckner landed a throw in the final seconds that led to a pin, which brought Andale within two at 34-32 with the final bout left.
Jake Goldenstein (106) had an 8-0 lead before getting a pin at 3:23 to start the Orioles with a 6-0 lead. Goldenstein is still undefeated on the season.
Andale got three straight wins, though none with pins, to take a 13-6 lead before the Orioles started their big run.
Brett Hamilton (145), Colton Clayborn (152) and Jacob Hill (170) all got easy wins for the Orioles.
Augusta will compete at the Remington tournament Saturday in the regular-season finale, then prepare for its home Class 4A regional tournament next weekend. Teams that will compete in that Regional include Andale, Buhler, Clearwater, El Dorado, Hesston, Hugoton, Mulvane, Nickerson, Pratt, Rose Hill, Towanda-Circle, Ulysses, Wellington and Winfield.


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Every day at Grace, students are impacted by an academic experience that strengthens character, sharpens competence, and prepares them for service. Your financial partnership plays a significant role in supporting Grace's mission—from helping build and maintain outstanding campus facilities to providing crucial student scholarships. The excellence and uniqueness of a Grace education would not be what it is without your gifts.
Give online, mail your gift, give over the phone, or set up an automatic transfer.


text: Save This Event For Later Bryan Park Training Series Season Pass Richmond, VA, Tue May 21 - Tue Sep 3, 2013 Who's Registered? | Contact Event | Event Website | Google Calendar Start line address: Richmond, VA 23227 Presented by Altius Cycling Team USA Cycling Permit # 2013-1640 This is a past event. If you wish to see the details for this event click, "Continue" below. If you are looking for a current event, please search the event calendar .


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The Glenwood City Council has passed a resolution that prohibits weapons from being brought into a building or onto a property owned, occupied or leased by the city of Glenwood.
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Posted on February 1, 2013
I don't suppose you're going to get around to asking me, but no, I have not met that many people who wound up on postage stamps.
It had not occurred to me, really, but most of the celebrities I hang around with on a day-to-day basis are, um, probably not going to make it. And my classmates from school are at the same awkward age I am (funny how that works out): too old to be child stars and too young for Nobel Prizes. And since you have to be dead, basically, to get on a U.S. postage stamp, I am reconciled to never seeing myself on a stamp unless one day authorities in Monaco or San Marino are just scraping the bottom of the barrel for ideas and decide to do a series on semi-famous bloggers. Or I could buy myself one of those computerized postage programs and print my own picture on the stamps, but that's not the sort of thing I was thinking about. (But I won't give up hope that somebody ELSE might put my face on a computerized bit of postage. I've had mail come in with Nancy Kerrigan and Gwen Stefani on them, so I suppose one day somebody…look, all I want is for some researcher to glance at an envelope in somebody's archives, squint a little, and cry out in awe "Who the heck is THAT?")
Where were we?
I had the catalog of the U.S. Postal Service arrive today, and among the 2012 stamps saluting Hawaiian shirts and the one with the toaster on it, I found the series honoring famous poets. And there among the other immortals was Illinois Poet Laureate, Newberry Library Fellow, Honorary Caxton Club member, and, incidentally, pretty decent human being Gwendolyn Brooks.
It was not what you'd call an auspicious occasion. She was late for dinner. When you get to dessert and the featured speaker has not yet appeared, the crowd gets restless. But she did show up. Turned out she had come straight from the hospital where her husband had just been rushed for what turned out to be a fatal problem. Her dinner had been saved for her, and we lingered over coffee while she fortified herself to meet the adoring crowd. The crowd had showed up precisely for the purposes of adoration, and I had spent the evening sitting next to someone who spent the whole meal rehearsing what he was going to say to her. (He had great chunks of her autobiography memorized and was going to quote them to her. I thought she might well have already read the book, but I try never to discourage the amusements of my elders and betters.)
She was going to sign books, too, so people had brought things from home. I was carrying one myself; it had been suggested to me that if I got a book from the Book Fair autographed by her, I could sell it at a great advantage to the Newberry. As it happened, I couldn't find any of her books, but there was one anthology—which we would have marked at fifty cents—in among the children's books.
When I reached the front of the line, I passed her this skinny paperback, which was the best I could do on short notice. I achieved the great goal of those who attend book signings, which is to get the Guest of Honor to initiate a conversation as you pass. She looked up at me and raised an eyebrow.
I swallowed hard. "You're on page 96," I said, opening the junior high poetry reader to her immortal "The Pool Players". "It was all I could find," I said. I learned later that Gwendolyn Brooks had the same regard for the poem that Dorothy Parker had for "One Perfect Rose": she didn't dislike it, but she wished people would realize she'd written other poems too.
I still have the book around here somewhere. She took that fifty cent book and inscribed that page to me personally. I suppose this looms larger in my autobiography than it would have in hers, had she gotten around to a third volume. A signed paperback book, if you're interested, is difficult to sell. And so much fuss has been made by the people who sell signed books about how inscriptions lower the value of the signature that an inscribed paperback is even more difficult, even if the signer did wind up on a postage stamp. I can't say, though, that I made the trip for nothing, since a book inscribed by Gwendolyn Brooks to me is worth something to me, if to nobody else. (And I did, after all, go back and pay the Book Fair fifty cents for it.)


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A short trip from Monocacy to Worthington Valley to visit Montmorenci. This property was first named in about 1734 by Samuel Worthington, Jr. The first house was built between 1823 and 1932. This home, Montmorenci, has been in the Worthington family into the 1900's.
As with Monocacy, here is how Captain John fits in.
Captain John and Sarah Howard Worthington
John Worthington, Jr 1689 – 1763
Samuel Worthington, 1734 – 1815
Walter Tolly Worthington 1765 – 1843
John Tolly Hood Worthington 1788 – 1849
John Tolly Worthington 1816 – 1859
Sallie Howard Worthington 1843 – 1917
Marie Conrad 1884 – 1921
As with Monocacy, the common ancestor is John Worthington, Jr, and Samuel and John Worthington III were brothers.
Of note: Samuel was married twice, and they had 22 children. All of the above named people, and many other Worthington's are buried at near by Saint Johns Episcopal Churchyard not to far from Montmorenci.
Please visit my headstone blog, where you can see all of the headstones of this family.
The Episcopal Church has played a role in this family from Captain John through this line. In Captain John's time, it was the Anglican Church, Saint Anne's in Annapolis to be specific. But the names of the above people can be found on the records at Saint Thomas Garrison Forest and Saint Johns (Western Run, as it had been called) Worthington Valley.
I hope to be able to worship at Saint John's on Sunday.
The map below, for me, puts a relationship between St. Thomas and St. Johns. St. Johns is about where the number 128 is above the green arrow. St. Thomas is the blue bubble.
Montmorenci is a beautiful home and not too far from Saint Johns. Here is a picture I took a couple of years ago, while visiting the house..
Then it's off to Darlington.


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Larry Kelly may be responsible for the operational and internal business activities of the Department of Energy's Oak Ridge Office, but the manager of DOE-ORO recently fielded broader questions about the relationship between DOE and the Oak Ridge community.
Larry Kelly may be responsible for the operational and internal business activities of the Department of Energy's Oak Ridge Office, but the manager of DOE-ORO recently fielded broader questions about the relationship between DOE and the Oak Ridge community.
Kelly was the guest speaker at a recent Oak Ridge Preservation and Heritage Association meeting. He shared a prepared slide presentation called "Managing Resources on the Oak Ridge Reservation in a Changing Environment." The presentation included bits of Kelly's background, his current responsibilities, and managing resources.
"Oak Ridge is one of DOE's most diverse sites," noted Kelly, stating the three sites in Oak Ridge — Oak Ridge National Laboratory, Y-12 National Security Complex and East Tennessee Technology Park (formerly the K-25 Site) — originally contained 70,000 acres. Today the reservation contains 33,500 acres.
The three sites in combination support several operational programs, which include science, environmental management, nuclear energy, and others.
Under Kelly's watch, the DOE-ORO has also done a major reorganization, which now includes five senior program managers, an integrated support center and has switched many responsibilities from the ORO to the site office.
After Kelly's short slide presentation, the questions came — about a dozen of them — many about forming relationships between DOE officials and city officials, and sharing information about what the future holds for preserving the past.
Kelly said communication is important, and he encouraged people to contact his office to schedule meetings and set up appointments.
About preservation issues, the manager said anything dealing with "property on the reservation has to follow federal law.
"In general, when we are approached about property, we have to balance what's best for the community, best for the environment and best for the government," Kelly explained.
Even though the reservation is nearly half its original size, he said the DOE is "doing some things to preserve history" and is committed to the Manhattan Project National Park plan.
DOE is preparing oral histories and working with environmental management at ETTP, and "calutrons are being maintained." However, because of security issues, calutrons may not be available for public viewing any time soon.
Other questions for the DOE-ORO chief dealt with pollution concerns, cleanup, and transferring property to public use.
Beverly Majors can be contacted at (865) 220-5514.


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Many Happy Returns: Stu juggles trouble when he decides to install a home burglar alarm himself and advises his daughter on first date kissing!
Father's Pet: It's seven days of trouble during "Be Kind To Animals Week" when the Erwins adopt guppies that breed like bunnies!
Spooks: Little sister Jackie causes trouble by spoiling her big sister's teen party when she steals the science lab skeleton! Special guest star Margaret Hamilton appears as Mrs. Bracker.
The Big Game: In an attempt to head-off potential trouble with vandalism at the school before the big football game, Principal Erwin and handyman Willy discover a statue belonging to the rival school in Stu's basement, and must return it before his daughter is blamed!


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Difference between revisions of "Dr.HeidiM.Mansour"
(→Past Research Lab Group Members (Alumni)& Current Positions)
(→Past Research Lab Group Members (Alumni) & Current Positions)
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4. Evan Mallory, Pharm.D. Graduate Researcher.
4. Evan Mallory, Pharm.D. Graduate Researcher.
==Past Research Lab Group Members (Alumni) & Current Positions==
==Past Research Lab Group Members (Alumni) & Current Positions==
1. Dr. Yun-Seok Rhee, Ph.D.,(SungKyunKwan University College of Pharmacy, S. Korea. Ph.D. Advisor: Dr. Eun-Seok Park), Postdoctoral Research Scholar.
1. Dr. Yun-Seok Rhee, Ph.D.,(SungKyunKwan University College of Pharmacy, S. Korea. Ph.D. Advisor: Dr. Eun-Seok Park), Postdoctoral Research Scholar.
Current Position: Assistant Professor, Gyeongsang National University, S. Korea.[http://www.ddscenter.com/intro/int_03_7.html]
Current Position: Assistant Professor, Gyeongsang National University, S. Korea.[http://www.ddscenter.com/intro/int_03_7.html]
Revision as of 20:40, 24 August 2014
Shalom Aleichem. Carpe Diem. Sursum.
- 1 "The Leading Research University in the American Southwest" "Sursum"
- 2 Websites
- 3 Professor Mansour Links
- 4 Education
- 5 Research Program
- 6 Editorial Advisory Board Member (EAB)& Scientific Advisor
- 7 National Expert Committees
- 8 Honors & Awards
- 9 Invited Speaker (2005-Present)
- 10 Short-Course/Workshop Instructor
- 11 Journal Publications
- 12 Edited Book (co-Editor)
- 13 Book Chapters
- 14 Professional Memberships
- 15 Honor Societies (Elected Member)
- 16 Current Research Lab Group Members
- 17 Past Research Lab Group Members (Alumni) & Their Current Positions
"The Leading Research University in the American Southwest" "Sursum"
The University of Arizona, College of Pharmacy, 1703 E. Mabel St., Office 434/Lab 435 Skaggs Pharmaceutical Sciences Center, Tucson, AZ 85721-0202.
Email: email@example.com Office Telephone: (520) 626-2768. Lab Telephone:(520) 626-3232
Research & Education: [1]
Graduate College Faculty Member:[2]
Faculty Member, The BIO5 Research Institute: [3]
Affiliated Faculty Member, Institute of the Environment: [4]
Associate Member [5], NCI Comprehensive Cancer Center: [6]
Google Scholar Publications: [7] PubMed Publications: [8] LinkedIn Profile: [9] Research Gate Profile: [10]
College of Pharmacy: http://www.pharmacy.arizona.edu
World Rankings in Pharmacy & Pharmacology (Global): http://www.topuniversities.com/university-rankings/university-subject-rankings/2014/pharmacy#sorting=rank+region=+country=+faculty=+stars=false+search=
World Rankings in Pharmacy & Pharmacology (USA):http://www.topuniversities.com/university-rankings/university-subject-rankings/2014/pharmacy#sorting=rank+region=+country=257+faculty=+stars=false+search=
The University of Arizona: http://www.arizona.edu/about/highlights-rankings
The University of Arizona Medical Center: http://uanews.org/story/university-of-arizona-medical-center-again-a-u-s-news-best-hospital
Professor Mansour Links
1. University of Wisconsin-Madison: [11] [12]
2. Tel Aviv University: [13] [14]
3. Harvard Medical School: [15]
4. Standford University School of Medicine: [16]
5. Emory University School of Medicine: [17]
6. University of Texas Southwestern Medical Center: [18]
7. Case Western Reserve University: [19]
8. University of Colorado-Denver:[20][21]
9.University of Utah: [22]
10.The University of Texas: [23]
Postdoctorate, University of North Carolina-Chapel Hill[24], School of Pharmacy[25], 1/2006-6/2008
Postdoctorate, University of Wisconsin-Madison[26], School of Pharmacy[27][28], 2004
Ph.D. Major-Pharmaceutical Sciences (Pharmaceutics & Drug Delivery), University of Wisconsin-Madison, School of Pharmacy, 12/2003
Ph.D. Minor-Advanced Physical & Biophysical Interfacial Chemistry, University of Wisconsin-Madison, Department of Chemistry, 12/1999
B.S.-Pharmacy (Distinction & Honors), University of Wisconsin-Madison, 5/1996
Research Program
Research in the Mansour lab focuses on the fundamental and applied aspects of surface and interfacial chemistry, nanotechnology, and particle engineering technologies in the design and optimization of advanced drug delivery systems. Multifunctional polymeric phospholipid (lipopolymeric) self-assemblies are optimized for targeted drug delivery, nanomedicine, and multifunctional microparticles and nanoparticles in the solid-state as dry powder inhalation aerosols in the targeted treatment and prevention of several pulmonary diseases. These microparticulate/nanoparticulate dry powders which are targeted directly to the lung as dry powder inhalers are biocompatible, biodegradable, mucopenetrating, and provide sustained drug release. We utilize various types of inhaler devices for both in vitro and in vivo rodent animal models. A systematic Quality-by-Design (QbD) approach in the solid-state is used and includes comprehensive physicochemical characterization, design of experiments (DOEs), performance modeling, and prediction. Pulmonary diseases with unmet medical needs that we investigate in vitro and in vivo include lung transplantation, lung cancer, infectious diseases, lung inflammatory fibrotic diseases, and autoimmune diseases. Our research program includes translational medicine, as exemplified by several successful collaborations with physician-scientists.
Editorial Advisory Board Member (EAB)& Scientific Advisor
1. Pharmaceutical Technology North America[29]
2. Recent Patents on Nanomedicine [30]
3. Recent Patents on Drug Delivery & Formulation [31]
4. Journal of Pharmaceutical Technology & Drug Research (United Kingdom) [32]
5. Journal of Pharmaceutical Sciences-Scientific Advisor to the Editors [33]
National Expert Committees
1. NIH/NICHD U.S. Pediatric Formulations Initiative (PFI) New Drug Delivery Systems (NDDS) Working Group-Aerosols
Honors & Awards
- 2010, Mercer School of Pharmacy Dept of Pharmaceutical Sciences, Pharmabeat 2010 Researcher of the Issue, Mercer University
- 2007-2008, Post Doctoral Fellow Award in Pharmaceutics, PhRMA Foundation
- 2007-2008, Post Doctoral Scholars Award for Research Excellence, Office of the Vice Chancellor, University of North Carolina at Chapel Hill
- 2007, Post Doctoral Fellow Award in Research Excellence, American Association of Pharmaceutical Scientists (AAPS)
- 2001, Walter F. Enz Award in Research Excellence in the Pharmaceutical Sciences, Pharmacia Upjohn Global Pharmaceutical Sciences
- 2000-2002, PhRMA Advanced Predoctoral Fellow Award in Pharmaceutics, Pharmaceutical Researchers & Manufacturers of America (PhRMA) Foundation
- 1999-2001, AFPE Predoctoral Fellow Award, American Foundation for Pharmaceutical Education (AFPE)
- 1996, Merck Award in Excellence in Pharmacy, Merck
- 1996, Distinction and Honors in Pharmacy, School of Pharmacy, University of Wisconsin-Madison
- 1994, Academic Excellence Award, Rho Chi Pharmaceutical Honor Society
- 1993, Sophomore Honors Award, College of Letters and Science, University of Wisconsin-Madison
- 1992, Chemistry Enrichment Award, Department of Chemistry, University of Wisconsin-Madison
- 1991-1995, Wisconsin Academic Excellence Award Scholar, Wisconsin Governor & Wisconsin State Legislature
- 1991, US Presidential Academic Fitness Award Scholar, President of the United States & the United States of America Congress
- 1991, Elected Member, Phi Eta Sigma National Honor Society
- 1991, Elected Member, Phi Kappa Phi National Honor Society
- 1991, Elected Member, Golden Key International Honor Society
Invited Speaker (2005-Present)
National and International Invited Speaker Presentations
1.Yale University, Department of Biomedical Engineering, New Haven, CT. 2005.
2.Harvard University, Division of Engineering and Applied Sciences, Cambridge, MA. 2005.
3.UNC-Chapel Hill, Chapel Hill, NC. 2005.
4.10th Annual Liposome Research Days & 1st UNC Drug Conference, Chapel Hill, NC. 2006.
5.American Oil Chemist's Society (AOCS) Annual Meeting & Exhibition, Phoenix, AZ. Symposium on Phospholipids:"Lipids in Nanotechnology II". Invited Speaker. Presentation Title: "Designed Phospholipid Self-Assemblies in Drug Delivery and Nanomedicine". 2010. [34]
6.American Oil Chemist's Society (AOCS) Annual Meeting & Exhibition, Cincinnati, OH. Symposium on "Phospholipids in Pharma and Cosmetics Applications". Invited Speaker. Presentation Title: "Phospholipid Nanopharmaceuticals in Advanced Drug Delivery". 2011. [35]
7.International Workshop on Physical Characterization of Pharmaceutical Solids (IWPCPS-13). Indianapolis, IN. Symposium on "Solid-State Transformation During Formulations and Processing". Invited Speaker. Presentation Title: "Water Vapor-Solid Interactions and Effects on Solid-State Phase Transitions in Engineered Microparticulate/Nanoparticulate Pharmaceutical Powders". 2011.
8. International Workshop on Physical Characterization of Pharmaceutical Solids (IWPCPS-13). Indianapolis, IN. Symposium on "Imaging of Drugs and Dosage Forms to Better Understand Dissolution". Invited Speaker. Presentation Title: "Imaging Techniques for Designed Microparticulate/Nanoparticulate Pharmaceutical Powders". 2011.
9. American Chemical Society (ACS) 242nd Annual Meeting & Exhibition, Division of Colloid & Surface Chemistry-Symposium on "Nanomedicine: Colloids & Surface Science". Denver, CO. Symposium Session Chair Presider & Invited Symposium Speaker. Presentation Title: "Rational Design, Development, and Optimization of Nanopharmaceuticals for Targeted Drug Delivery in Nanomedicine: An Interfacial and Colloidal Science Approach". 2011.
10. 4th Annual AAPS Nanotechnology & Nanomedicine Symposium, Louisville, KY. Invited Speaker. Presentation Title: "Advanced Spray-Dried Vancomycin Hydrochloride and Clarithromycin Lipospheres for Targeted Pulmonary Inhalation Aerosol Delivery." 2011.
11. Pfizer, Inc., Worldwide Research & Development, Global Headquarters, Groton, CT. Invited Speaker. Presentation Title: "Engineering Particles by Advanced Spray Drying for Drug Delivery." 2011.
12. Center for Pulmonary Research, Children's Hospital Research Institute, The Ohio State University, Columbus, OH. Invited Speaker in the Translational Pulmonary Research Seminar Series. Presentation Title: "Advances in Targeted Lung Nanomedicine as Inhalable Multifunctional Microparticles & Nanoparticles for Pulmonary Disease Treatment and Prevention." 2012.
13. International Conference & Exhibition on Nanotechnology & Nanomedicine. Omaha, NE. Invited Speaker. Presentation Title: "Advances in Targeted Lung Nanomedicine as Inhalable Multifunctional Microparticles & Nanoparticles for Pulmonary Disease Treatment and Prevention." 2012.
14.Transcept Pharmaceuticals. Invited Webinar Speaker. Presentation Title: "Fundamental and Applied Aspects of Sustained Release Injectible Depot Delivery". 2012.
15. Buchi Hands-On Spray Drying Course, Buchi U.S. Headquarters. New Castle, DE. Invited Speaker. Presentation Title: "Engineering Particles by Advanced Organic Solution Spray Drying for Nanopharmaceuticals and Targeted Pulmonary Inhalation Aerosol Delivery." 2012. [36]
16. Lovelace Respiratory Research Institute (LRRI). Albuquerque, NM. Invited Speaker in the LRRI and CNTC Seminar Series. Presentation Title:"Advances in Targeted Lung Nanomedicine as Aerosolized Multifunctional Microparticles and Nanoparticles for Pulmonary Disease Treatment and Prevention." 2012. [37]
17. Controlled Release Society (CRS) 39th Annual Meeting & Exhibition. Quebec City, Quebec, Canada. Invited Speaker. CRS Workshop: "Mucosal Drug and Gene Delivery: Barriers and Opportunities." Presentation Title: "Pulmonary Drug Delivery". 2012.[38]
18. 1st International Symposium on Nanomedicine in Drug Delivery and Cancer Diagnosis. University of Delaware, College of Health Sciences, Newark, DE. Organizing Committee Member [39]. Nano Drug Delivery Session Chair Presider [40]. Invited Symposium Speaker in the Nanomedicine Session. Presentation Title: "Advances in Targeted Lung Nanomedicine as Multifunctional Microparticles & Nanoparticles for Targeted Pulmonary Delivery." 2012. [41]
19. Wayne State University Applebaum College of Pharmacy, Department of Pharmaceutical Sciences Seminar Series. Detroit, MI. Invited Speaker. 2012.[42]
20. North American Cystic Fibrosis Conference (NACFC), Orlando, FL. Invited Symposium Speaker. NACFC Aerosol Symposium: "Aerosol Treatments in CF: Clearing the Fog." Presentation Title: "Aerosol Formulation Issues." 2012.[43]
21. 19th World Congress of the International Society of Aerosols in Medicine (ISAM), Chapel Hill, NC. Invited Speaker. ISAM Workshop: "Nanomedicine & Nanotoxicology: Inhaling nanoparticles by accident and on purpose-challenges and opportunities for toxicology and therapeutics." Presentation Title: "Nanotechnology in Dry Powder Inhalation Aerosol Formulations." 2013.[44]
22. AAPS/USP/FDA/IPAC Workshop on Inhaled Drug Products, United States Pharmacopeia (USP), Rockville, MD. Invited Speaker. "Inhaled Drug Products: Current Practices and the Future of In Vitro Testing Technologies and Regulation." Presentation Title: "Solid-State Characterization and Nanotechnology in Inhalation Aerosol Formulation Development." 2013. [45]
23. Association of Inhalation Toxicologists (AIT) Annual Conference, Hannover, Germany. Invited Speaker. Session: "Nanomaterials." Presentation Title: "Nanomaterials as an Aerosol Formulation Carrier in Inhalation Aerosol Nanomedicine." 2013. [46]
24. Eastern Analytical Symposium & Exhibition (EAS), Somerset, NJ. Invited Speaker. Coblentz EAS Session: "Spectroscopic Applications in Biologics." Presentation Title:"Characterization and Spectroscopic Applications in Pulmonary Delivery and Advanced Dry Powder Inhalers." 2013. [47] [48]
25.Buchi Hands-On Spray Drying Course, Newark, DE. Invited Speaker. Presentation Title: "Designing High Performing Microparticulate/Nanoparticulate Dry Powder Inhalers by Organic Solution Advanced Spray Drying." 2014. [49]
Short-Course/Workshop Instructor
1.Aerosol School 2-Day Workshop: "Aerosol Science Fundamentals and Inhalation Aerosol Delivery", NIH-NCI Cancer Nanotechnology Training Center (CNTC), April 17-18 2012.
Journal Publications
== 2001-2009 ==
1. Mansour H., Wang D.-S., Chen C.-S., and Zografi G. Comparison of Bilayer and Monolayer Properties of Phospholipid Systems Containing Dipalmitoylphosphatidylglycerol and Dipalmitoylphosphatidylinositol. Langmuir (2001) 17 (21) October 16: 6622-6632. (Impact Factor: 4.384)[50]
2. Mansour, H.M. and Zografi G. The Relationship Between Water Vapor Absorption and Desorption by Phospholipids and Bilayer Phase Transitions. Journal of Pharmaceutical Sciences (2007) 96 (2) February: 377-396. (Impact Factor: 3.007)[51]
3. Mansour, H.M. and Zografi G. Relationships Between Equilibrium Spreading Pressure and Phase Equilibria of Phospholipid Bilayers and Monolayers at the Air-Water Interface. Langmuir (2007) 23 (7) March 27: 3809-3819. (Impact Factor: 4.384)[52]
4. Hickey, A.J., Mansour, H.M., et al. Physical Characterization of Component Particles Included in Dry Powder Inhalers: I. Strategy Review and Static Characteristics. Journal of Pharmaceutical Sciences: Special Issue David Grant Dedicated Issue (2007) 96 (5) May: 1282-1301. (Impact Factor: 3.007)[53]
5. Hickey, A.J., Mansour, H.M., et al. Physical Characterization of Component Particles Included in Dry Powder Inhalers: II. Dynamic Characteristics. Journal of Pharmaceutical Sciences: Special Issue David Grant Dedicated Issue (2007) 96 (5) May: 1302-1319. (Impact Factor: 3.007)[54]
6. Mansour, H.M. and Hickey, A.J. Raman Characterization and Chemical Imaging of Biocolloidal Self-Assemblies, Drug Delivery Systems, and Pulmonary Inhalation Aerosols. A Review. AAPS PharmSciTech (2007) 8 (4) November 30: Article 99:E1-E16. (Impact Factor: 1.776)[55]
7. Xu, Z., Mansour, H.M., Mulder, T., McLean, R., Langridge, J., and Hickey, A.J. Comparative Dispersion Study of Dry Powder Aerosols of Albuterol Sulfate/Lactose Monohydrate and Cromolyn Sodium/Lactose Monohydrate Delivered by Standardized Entrainment Tubes. Respiratory Drug Delivery (2008) 3: 897-900. [56]
8. Mansour H.M., Damodaran S., and Zografi G. Characterization of the In Situ Structural and Interfacial Properties of the Cationic Hydrophobic Heteropolypeptide, KL4, in Lung Surfactant Bilayer and Monolayer Models at the Air-Water Interface: Implications for Pulmonary Surfactant Delivery. Molecular Pharmaceutics (2008) 5 (5) October 6: 681-695. (Impact Factor: 4.787)[57]
9. Mansour, H.M., Rhee, Y.S., and Wu, X. Nanomedicine in Pulmonary Delivery. International Journal of Nanomedicine (2009) 4 December: 299-319.(Impact Factor: 4.195)[58]
== 2010 ==
10. Xu, Z., Mansour, H.M., Mulder, T., McLean, R., Langridge, J., and Hickey, A.J. Dry Powder Aerosols Generated by Standardized Entrainment Tubes from Drug Blends with Lactose Monohydrate: 1. Albuterol Sulfate and Disodium Cromoglycate. Journal of Pharmaceutical Sciences (2010) 99 (8) March 2: 3398-3414.(Impact Factor: 3.007)[59]
11. Xu, Z., Mansour, H.M., Mulder, T., McLean, R., Langridge, J., and Hickey, A.J. Dry Powder Aerosols Generated by Standardized Entrainment Tubes from Drug Blends with Lactose Monohydrate: 2. Ipratropium Bromide Monohydrate and Fluticasone Propionate. Journal of Pharmaceutical Sciences (2010) 99 (8) March 10: 3415-3429. (Impact Factor: 3.007)[60]
12. Mansour, H.M., Xu, Z., and Hickey, A.J. Dry Powder Aerosols Generated by Standardized Entrainment Tubes from Alternative Sugar Blends: 3. Trehalose Dihydrate and D-Mannitol Carriers. Journal of Pharmaceutical Sciences (2010) 99 (8) March12; 3430-3441.(Impact Factor: 3.007)[61]
13. Xu, Z., Mansour, H.M., Mulder, T., McLean, R., Langridge, J., and Hickey, A.J. Heterogenous Particle Deaggregation and Its Implications for Therapeutic Aerosol Performance. Journal of Pharmaceutical Sciences (2010) 99 (8) March 15: 3442-3461.(Impact Factor: 3.007)[62]
14. Mansour, H.M., Sohn, M., Al-Ghananeem, A., and DeLuca P.P. Materials for Pharmaceutical Dosage Forms: Molecular Pharmaceutics and Controlled Release Drug Delivery Aspects. Invited Paper. International Journal of Molecular Sciences: Special Issue-Material Sciences and Nanotechnology Section - Biodegradability of Materials in Biomedical Applications. (2010) 11: 3298-3322. (Impact Factor: 2.339)[63]
15. Rhee, Y.S., Park, C.W., DeLuca, P.P., and Mansour, H.M. Sustained-Release Injectable Drug Delivery Systems. An Invited Paper. Pharmaceutical Technology: Special Issue-Drug Delivery (2010) November: 6-13. [64]
16. Hayes, D. Jr., Zwischenberger, J.B., and Mansour, H.M. Aerosolized Tacrolimus: A Case Report in a Lung Transplant Recipient. Transplantation Proceedings (2010) 42 (9) November: 3876-3879.(Impact Factor: 1.061) [65]
17. Wu, X., Li, X., and Mansour, H.M. Surface Analytical Techniques in Solid-State Particle Characterization: Implications for Predicting Performance in Dry Powder Inhalers. Invited Paper. KONA Powder and Particle Journal (2010) 28: 3-19/ (Impact Factor: 1.227) [66]
== 2011 ==
18. Xu, Z., Mansour, H.M., and Hickey, A.J. Particle Interactions in Dry Powder Inhaler Unit Processes. Journal of Adhesion Science and Technology: Special Issue on Adhesion Aspects in Pharmaceutical Sciences (2011): 25 (4/5) 451-482. (Impact Factor: 1.175)[67]
19. Rhee, Y.S. and Mansour, H.M. Nanopharmaceuticals I: Nanocarrier Systems in Drug Delivery. Invited Paper. International Journal of Nanotechnology: Special Issue-Nanopharmaceuticals. (2011) 8 (1/2): 84-114.(Impact Factor: 1.144)[68]
20. Wu, X. and Mansour, H.M. Nanopharmaceuticals II: Application of Nanoparticles and Nanocarrier Systems in Pharmaceutics and Nanomedicine. Invited Paper. International Journal of Nanotechnology: Special Issue-Nanopharmaceuticals. (2011) 8 (1/2): 115-145. (Impact Factor: 1.144)[69]
21. Wu, X.,and Mansour, H.M. Pulmonary and Nasal Anti-Inflammatory and Anti-Allergy Inhalation Aerosol Delivery Systems. Invited Paper. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry: Special Issue-Optimizing a Therapeutic with Anti-Inflammatory Agents: Novel Drug Delivery Systems. (2011)10 (3): 215-229. [70]
22. Park, C.W., Hayes, D. Jr., and Mansour, H.M. Pulmonary Inhalation Aerosols for Targeted Antibiotics Drug Delivery. Invited Paper & Cover Page. European Pharmaceutical Review. (2011) 16 (1): 32-36.[71]
23. Mansour, H.M. Molecular Forces and Self Assembly in Colloid, Nano Sciences and Biology. Invited Paper. Journal of the American Chemical Society. (2011) 133 (13): 5162. (Impact Factor: 9.907) [72]
24. Hayes, D. Jr and Mansour, H.M. Improved Outcomes of Patients with End-Stage Cystic Fibrosis Requiring Invasive Mechanical Ventilation for Acute Respiratory Failure. Lung. (2011) 189 (5): 409-415. (Impact Factor: 2.171)[73] [74]
25. Hayes, D. Jr., Ball, A.M., Mansour, H.M., Martin, C.A.,and Flynn, J.D. Fungal Infection in Heart-Lung Transplant Recipients Receiving Single-agent Prophylaxis With Itraconazole. Experimental and Clinical Transplantation (2011)9 (6): 399-404. [75].
26. Rhee, Y.S., Sohn, M., Woo, B.H., Thanoo, B.C., DeLuca, P.P., and Mansour, H.M. Sustained-Release Delivery of Octreotide from Biodegradable Polymeric Microspheres. AAPS PharmSciTech: Special Theme Issue-Sterile Products: Advances and Challenges in Formulation, Manufacturing, Devices and Regulatory Aspects.(2011)12 (4):1293-1301. (Impact Factor: 1.776)[76] [77]
27. Li, X. and Mansour, H.M. Physicochemical Characterization and Water Vapor Absorption of Organic Solution Advanced Spray Dried Trehalose Microparticles and Nanoparticles for Targeted Dry Powder Pulmonary Inhalation Delivery. AAPS PharmSciTech: Special Theme Issue: Advances in Pharmaceutical Excipients Research and Use: Novel Materials, Functionalities and Testing (2011)12(4):1420-1430. (Impact Factor: 1.776)[78] [79]
== 2012 ==
28. Hayes, D. Jr., Winkler, M.A., Kirkby, S., Capasso, P., Mansour, H.M. and Attili, A.K. Preprocedural Planning with Prospectively Triggered Multi-Detector Row CT Angiography prior to Bronchial Artery Embolization in Cystic Fibrosis Patients with Massive Hemoptysis. Lung (2012)190 (2)April:221-225.(Impact Factor: 2.171)[80]
29. Hayes, D. Jr. and Mansour, H.M. Vanishing Bronchus Intermedius Syndrome in a Pediatric Patient with Cystic Fibrosis After Lung Transplantation. Pediatric Transplantation: The Official Journal of the International Pediatric Transplant Association (2012)16(8):333-337. [Impact Factor: 1.630][81]
30. Hayes, D. Jr., Mansour, H.M., Kirkby, S., and Phillips, A.B. Rapid Acute Onset of Bronchiolitis Obliterans Syndrome in a Lung Transplant Recipient After Respiratory Syncytial Virus Infection." Transplant Infectious Diseases (2012)14 (5): 548-550. [Impact Factor: 2.25][82]
31. Duan, J.H., Mansour, H.M., Zhang, Y.D., Deng, X.M., Zhao, J.F. Reversion of Multi-Drug Resistance by Co-Encapsulation of Doxorubicin and Curcumin in Chitosan/poly(butylcyanoacrylate) Nanoparticles. International Journal of Pharmaceutics (2012) 426 (1-2): 193-201. (Impact Factor: 3.785)[83]
32. Park, C.W., Mansour, H.M., Oh, T.O., Kim, J.Y., Ha, J.M., Lee, B.J., Chi, S.C., Rhee, Y.S., Park, E,S. "Phase behavior of itraconazole-phenol mixtures and its pharmaceutical applications." International Journal of Pharmaceutics (2012) 436 (1-2):652-658.(Impact Factor: 3.785) [84]
33. Park, C.W., Rhee, Y.S., Vogt, F.G., Hayes, D Jr., Zwischenberger, J.B., DeLuca, P.P., and Mansour, H.M. Advances in Microscopy and Complementary Imaging Techniques to Assess the Fate of Drugs Ex-Vivo in Respiratory Drug Delivery. Invited Paper. Advanced Drug Delivery Reviews: Special Theme Issue-Computational and Visualization Approaches in Respiratory Delivery. (2012) 64 (4) March 30: 344-356. (Impact Factor: 12.707)[85]
34. Willis, M.L., Hayes, D Jr., and Mansour, H.M. Therapeutic Liposomal Dry Powder Inhalation Aerosols for Targeted Lung Delivery. Lung (2012) 190 (3): 251-262.(Impact Factor: 2.171)[86] [87]
35.Mansour, H.M. "Aerosol Formulation Issues." Pediatric Pulmonology (2012) 47 (35):149-151. (Impact Factor: 2.297) [88]
== 2013 ==
36. Meenach, S.A. Vogt,F.G., Anderson, K.W., Hilt, J.Z., McGarry,R.C., and Mansour, H.M.. Design, Physicochemical Characterization, and Optimization of Organic Solution Advanced Spray-Dried Inhalable Dipalmitoylphosphatidylcholine (DPPC) and Dipalmitoylphosphatidylethanolamine Poly(Ethylene Glycol) (DPPE-PEG) Microparticles and Nanoparticles for Targeted Respiratory Nanomedicine Delivery as Dry Powder Inhalation Aerosols. International Journal of Nanomedicine (2013) 8:275-293.(Impact Factor: 4.195)[89]
37. Meenach, S.A., Anderson, K.W., Hilt, J.Z., McGarry, R.C., and Mansour, H.M. Characterization and Aerosol Dispersion Performance of Advanced Spray-Dried Chemotherapeutic PEGylated Phospholipid Particles for Dry Powder Inhalation Delivery in Lung Cancer. European Journal of Pharmaceutical Sciences (2013) 49 (4): 699-711.(Impact Factor: 3.005)[90]
38. Wu,X., Hayes, D Jr., Zwischenberger, J.B., Kuhn, R.J., and Mansour, H.M. Design and Physicochemical Characterization of Advanced Spray-Dried Tacrolimus Multifunctional Particles for Inhalation. Drug Design, Development, and Therapy (2013) 7:59-72. (Impact Factor: 3.026) [91]
39. Wu,X., Zhang, W., Hayes, D Jr., and Mansour, H.M. Physicochemical Characterization and Aerosol Dispersion Performance of Organic Solution Advanced Spray-Dried Cyclosporine A Multifunctional Particles for Dry Powder Inhalation Aerosol Delivery. International Journal of Nanomedicine (2013) 8 :1269-1283.(Impact Factor: 4.195)[92]
40. Park, C.W., Li X., Vogt, F.G., Hayes, D. Jr., Zwischenberger, J.B., Park, E.S. and Mansour, H.M. Advanced Spray Dried Design, Physicochemical Characterization and Aerosol Dispersion Performance of Vancomycin and Clarithromycin Multifunctional Controlled Release Particles for Targeted Respiratory Delivery as Dry Powder Inhalation Aerosols.. International Journal of Pharmaceutics (2013) 455 (1–2): 374–392.(Impact Factor: 3.785)[93]
41. Zheng Z, Zhang W, Sun W, Li X, Duan J, Cui J, Feng Z, and Mansour, H.M. Influence of the Carboxymethyl Chitosan Anti-Adhesion Solution on the TGF-β1 in a Postoperative Peritoneal Adhesion Rat. Journal of Materials Science: Materials in Medicine (2013) 24 (11): 2549-2559. (Impact Factor: 2.379) [94]
42. Duan J.H., Vogt, F.G., Li X., Hayes, D. Jr., and Mansour, H.M. Design, Physicochemical Characterization and Aerosolization of Organic Solution Advanced Spray Dried and Co-Spray Dried Moxifloxacin and Ofloxacin Dipalmitoylphosphatidylcholine (DPPC) Microparticulate/Nanoparticulate Powders for Pulmonary Inhalation Aerosol Delivery. International Journal of Nanomedicine (2013) 8: 3489-3505. [95](Impact Factor: 4.195)
43. Hayes, D. Jr., Galantowicz, M., Yates, A.R., Preston, T.J., Mansour, H.M., and McConnell, P.I. Venovenous ECMO as a Bridge to Lung Transplant and Protective Strategy for Subsequent Primary Graft Dysfunction. Journal of Artificial Organs (2013) 16 (3): 382-385. (Impact Factor: 1.60)[96]
44. Hayes, D. Jr., Baker, P.B., Mansour, H.M., Peeples, M.E., and Nicol, K.K. Interstitial Lung Disease in a Child with Antisynthetase Syndrome. Lung (2013) 191 (4): 441-443. (Impact Factor: 2.171)[97]
45.Hayes, D. Jr., Daniels, C.J., Mansour, H.M., Kopp, B.T., Yates, A.R., McCoy, K.S., Patel, A.V., and Kirby, S. Right Heart Catherization Measuring Central Hemodynamics in Cystic Fibrosis During Exercise. Respiratory Medicine (2013): 107 (9): 1365–1369. [Impact Factor: 2.917][98]
46. Hayes, D. Jr., Daniels, C.J., Mansour, H.M., Kopp, B.T., Yates, A.R., Preston, T., and Kirby, S. Identification of the Nodose Ganglia and TRPV1 in Swine. Lung (2013): 191(5):445-447(Impact Factor: 2.171)[99]
47.Hayes, D Jr., Kirkby, S., McCoy, K.S., Mansour, H.M., Khosravi, M., Strawbridge, H., and Tobias, J.D. Reduction of Lipid-Laden Macrophage Index After Laproscopic Nissen Fundoplication in Cystic Fibrosis Patients After Lung Transplantation. Clinical Transplantation (2013) 27 (1): 121-125.(Impact Factor: 1.486) [100]
== 2014 ==
48. Hayes, D. Jr., Yates, A.R., Duffy, V., Tobias, J., Mansour, H.M., Olshove, V., and Preston, T.J. Rapid placement of bicaval dual-lumen catheter in a swine model of venovenous ECMO. Journal of Investigative Surgery (2014): 27(1):27-31. [Impact Factor: 1.316] [101]
49. Hayes, D. Jr., Adler, B., Turner, T.L., and Mansour, H.M.. Alternative Tacrolimus and Sirolimus Regimen Associated with Rapid Resolution of Posterior Reversible Encephalopathy Syndrome After Lung Transplantation. Pediatric Neurology (2014) 50: 272-275.(Impact Factor: 1.504)[102]
50. Li X., Vogt, F.G., Hayes, D. Jr., and Mansour, H.M. Physicochemical Characterization and Aerosol Dispersion Performance of Organic Solution Advanced Spray Dried Microparticulate/Nanoparticulate Antibiotic Dry Powders of Tobramycin and Azithromycin for Pulmonary Inhalation Aerosol Delivery. European Journal of Pharmaceutical Sciences (2014) 15: 191-205. (Impact Factor: 3.005) [103]
51.Li X., Vogt, F.G., Hayes, D. Jr., and Mansour, H.M. Design, Characterization, and Aerosol Dispersion Performance Modeling of Advanced Spray-Dried Microparticulate/Nanoparticulate Mannitol Powders for Targeted Pulmonary Delivery as Dry Powder Inhalers. Journal of Aerosol Medicine & Pulmonary Drug Delivery (2014): 27 (2):81-93. (Impact Factor: 2.395)[104]
52. Li X., Vogt, F.G., Hayes, D. Jr., and Mansour, H.M. Design, Characterization, and Aerosol Dispersion Performance Modeling of Advanced Co-Spray Dried Antibiotics with Mannitol as Respirable Microparticles/Nanoparticles for Targeted Pulmonary Delivery as Dry Powder Inhalers. Journal of Pharmaceutical Sciences: George Zografi Dedicated Issue (2014)103(9): 2937-2949. [Impact Factor: 3.007][105]
53. Muralidharan, P., Mallory, E., Malapit, M., Hayes, D. Jr., and Mansour, H.M. Inhalable PEGylated Phospholipid Nanocarriers and PEGylated Therapeutics for Respiratory Delivery as Aerosolized Colloidal Dispersions and Dry Powder Inhalers. Pharmaceutics: Special Issue: Liposomal Technologies (Guest Editor: Prof. Timothy D. Heath, UW-Madison) (2014) 6 (2): 333-353. [106] [107]
54. Meenach, S.A., Anderson, K.W., Hilt, J.Z., McGarry, R.C., and Mansour, H.M. High-Performing Dry Powder Inhalers of Paclitaxel DPPC/DPPG Lung Surfactant-Mimic Multifunctional Particles in Lung Cancer: Physicochemical Characterization, In Vitro Aerosol Dispersion, and Cellular Studies. AAPS PharmSciTech: Theme Issue on Advances in Formulation and Device Technologies in Pulmonary Drug Delivery (2014) IN PRESS. [Impact Factor: 1.776] [108] [109]
55. Hayes, D. Jr., McCoy, K.S., Whitson, B.A., Mansour, H.M., and Tobias, J.D. High-Risk Age Window for Mortality in Children with Cystic Fbrosis After Lung Transplantation. Pediatric Transplantation (2014) IN PRESS. [Impact Factor: 1.63] [110]
Edited Book (co-Editor)
1. Nanomedicine in Drug Delivery, Kumar, A., Mansour, H.M., Friedman, A., and Blough, E. (Editors), CRC Press/Taylor & Francis, London, United Kingdom. (2013) 469 pages. ISBN: 9781466506169 [111][112][113]
Book Chapters
1. Hickey, A.J. and Mansour, H.M. Book Volume 2, Book Chapter 43: Formulation Challenges of Powders for the Delivery of Small Molecular Weight Molecules as Aerosols. Modified-Release Drug Delivery Technology, Drugs and the Pharmaceutical Sciences Series.728 pages. Rathbone, M. J., Hadgraft, J., Roberts, M.S., Lane, M.E, (Editors), Second Edition, Informa Healthcare, New York, (2008): pp. 573-602. ISBN: 9781420053555 [114]
2. Hickey, A.J. and Mansour, H.M. Book Volume 2, Book Chapter 5: Delivery of Drugs by the Pulmonary Route. Modern Pharmaceutics Volume 2: Applications and Advances, Drugs and the Pharmaceutical Sciences Series,.500 pages. Florence, A.T., Siepmann, J. (Editors), Fifth Edition, Informa Healthcare, New York, (2009): 191-219. ISBN: 9781420065664 [115]
3. Mansour, H.M., Rhee, Y.S., Park, C.W., and DeLuca, P.P. Book Chapter 9: Lipid Nanoparticulate Drug Delivery and Nanomedicine. Lipids in Nanotechnology. 306 pages. Moghis, A. (Editor), American Oil Chemists Society (AOCS) Press, Urbana, Illinois (2012): pp.221-268.ISBN: 9780981893679 [116]
4. Mansour, H.M., Park, C.W., and Hayes, D. Jr. Book Chapter 3: Nanoparticle Lung Delivery and Inhalation Aerosols for Targeted Pulmonary Nanomedicine. Nanomedicine in Drug Delivery. 469 pages. Kumar, A., Mansour, H.M., Friedman, A., Blough, E. (Editors), CRC Press/Taylor & Francis, Inc., London, United Kingdom. (2013): pp.43-74. ISBN: 9781466506169 [117] [118][119]
5. Mansour, H.M. and Park, C.W. Book Chapter 7: Therapeutic Applications and Targeted Delivery of Nanomedicines and Nanopharmaceutical Products. The Clinical Nanomedicine Handbook. 365 pages. Brenner, S.A. (Editor), CRC Press/Taylor & Francis, Inc., London, United Kingdom. (2013): pp.321-338. ISBN: 9781439834787 [120]
6. Mansour, H.M., Xu, Z., Meenach, S.A., Park, C.W., Rhee, Y.S., and DeLuca, P.P. Book Chapter 5: Novel Drug Delivery Systems. Drug Delivery. 550 pages. Mitra, A.K. (Editor), Jones & Bartlett, Burlington, MA. (2015): pp.71-107. ISBN-13: 9781284025682 [121]
7. Mansour, H.M., Park, C.W., and Bawa, R. Book Chapter: Design and Development of Approved Nanopharmaceutical Products. Handbook of Clinical Nanomedicine: From Bench to Bedside. 1000+ pages. Bawa,R., Audette, G., and Rubinstein, I. (Editors), Pan Stanford Publishing, Singapore. (2015): pp.1-33. ISBN: 9789814316170 [122]
8. Mansour, H.M., Muralidharan, P., and Hayes, D. Jr. Book Chapter 8b: Inhaled Nanoparticulate Systems. The ISAM Textbook of Aerosol Medicine. Dhand, R. (Editor-in-Chief), Rothen-Rutishauser, B., and Hickey A.J. (Associate Editors), International Society of Aerosols in Medicine (ISAM)/Mary Ann Libert Publishing, Inc. Rochelle, NY. (2015).
9. Mansour, H.M., Myrdal, P.B., Younis, U., Muralidharan, P., and Hayes, D. Jr. Book Chapter 12: Pulmonary Drug Delivery. Drug Delivery & Targeting. Hillery, A.M., Swarbrick, J., and Park, K., (Editors), Second Edition, CRC Press/Taylor & Francis, Inc., London, United Kingdom. (2015)
Professional Memberships
1.Academy of Pharmaceutical Sciences of Great Britain (APSGB)
2.American Thoracic Society (ATS)
3.American Pharmacists Association (APhA)[123]
4.American Chemical Society (ACS)
5.American Association of Pharmaceutical Scientists (AAPS)
6.American Association of the Colleges of Pharmacy (AACP)
7.American Society for Nanomedicine (ASNM)
8.Controlled Release Society (CRS)
9.European Federation for Pharmaceutical Sciences (EUFPS)
10.International Pharmaceutical Federation (FIP) Board of Pharmaceutical Specialties
11.European Cystic Fibrosis Society (ECFS)
12.International Society for Aerosols in Medicine (ISAM)
13.The Aerosol Society (Great Britain)
14.International Association of Colloid and Interface Scientists (IACIS)
Honor Societies (Elected Member)
1. Phi Eta Sigma National Honor Society
2. Phi Kappa Phi National Honor Society
3. Golden Key International Honor Society
4. Rho Chi Pharmaceutical Honor Society
5. Sigma Xi Scientific Research Honor Society
Current Research Lab Group Members
1. Priya Muralidharan, M.S.(New Jersey Institute of Technology-Pharmaceutical Engineering), Graduate Student & Lab Manager.
2. Maria Acosta, Pharm.D., CONACyT Graduate Student Research Fellow
3. Monica Malapit, Pharm.D. Graduate Researcher.
4. Evan Mallory, Pharm.D. Graduate Researcher.
Past Research Lab Group Members (Alumni) & Their Current Positions
1. Dr. Yun-Seok Rhee, Ph.D.,(SungKyunKwan University College of Pharmacy, S. Korea. Ph.D. Advisor: Dr. Eun-Seok Park), Postdoctoral Research Scholar. Current Position: Assistant Professor, Gyeongsang National University, S. Korea.[124]
2. Dr. Xiao Wu, Ph.D.(University of Bath College of Pharmacy, Bath, England. Ph.D. Advisor: Dr. Richard Guy), Postdoctoral Research Scholar. Current Position: Formulation Chemist, Eli Lilly and Company (Elanco), Indianapolis, IN.
3. Dr. Chun-Woong Park, Ph.D.(SungKyunKwan University College of Pharmacy, S. Korea. Ph.D. Advisor: Dr. Eun-Seok Park), Postdoctoral Research Scholar. Current Position: Assistant Professor, Chungbuk National University College of Pharmacy, S. Korea [125]
4. Dr. Jinghua Duan, Ph.D., (School of Medicine, Central South University, P.R China. Ph.D. Advisor: Dr. Jinfeng Zhao), Postdoctoral Research Scholar. Current Position: Research Associate, University of Washington-Seattle.
5. Dr. Samantha Meenach, Ph.D. (UK College of Engineering, Major Professor: Dr. Kim W. Anderson), NIH NCI CNTC Postdoctoral Fellow. Current Position: Assistant Professor of Chemical Engineering, University of Rhode Island. [126]
6. Dr. Wei Fen Zhang, M.D., Ph.D., Visiting Professor. Current Position: Associate Professor, School of Pharmaceutical & Biological Science,Weifang Medical University, Shedong, P.R. China.
7. Dr. Scott Silva, M.D., Ph.D.(UK College of Medicine, Major Professor: Dr. Mark Evers),Postdoctoral Physician-Scientist NIH CCTS PSMRF Research Fellow. Current Position: Clinical Faculty, Loyola School of Medicine, Radiation Oncology.
8. Dr. Sung Gu Han, Ph.D.(UK College of Medicine, Major Professor: Dr. Gary Gairola), Postdoctoral Research Associate. Current Position: Assistant Professor, Konkuk University College of Animal Bioscience and Technology, Seoul, S. Korea. [127]
9. MinJi Sohn, M.S., Visiting Graduate Student Research Scholar
10. Xiaojian Li, M.S., Ph.D., Daniel P. Reedy Fellow, Quality Achievement Fellow, Center of Membrane Sciences Fellow, S. Elizabeth Helton Memorial Pulmonary Research Travelship, Boehringer Ingelheim intern. Current Position: Senior Formulation Scientist, AMRI (Albany Molecular Research, Inc.), Albany, NY.
11. Dr. Lauren Willis, Pharm.D. Researcher. Current Position: Clinical Faculty at MD Anderson Cancer Center
12. Nathanael Stocke, NSF-IGERT Fellow & NIH NCI CNTC Fellow, College of Engineering[128] [129] [130]
13. Alexander McKinlay, NSF-REU Fellow/NSF-REU co-Advisor, Department of Biomedical Engineering[131]


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Carolyn Krause provides insight into repercussions of the 1983 revelation that mercury from Y-12 had gotten into East Fork Poplar Creek.
Carolyn Krause provides insight into repercussions of the 1983 revelation that mercury from Y-12 had gotten into East Fork Poplar Creek. This information resulted in several levels of investigations and reports. Carolyn gives examples of the events and reports, as well as the people involved in the historic mercury investigations.
On May 17, 1983 — 30 years ago this past Friday — the Department of Energy made an historical announcement about its releases of mercury from the Oak Ridge Y-12 Plant to the environment. It was a watershed in the history of U.S. efforts to protect human health and the natural environment.
The massive political, governmental, media, managerial, scientific and engineering responses to this announcement set into motion the ongoing nationwide remediation of government sites contaminated with radioactive materials, heavy metals and chemicals.
Environment, safety and health became a high priority when John Herrington became Secretary of Energy in February 1985 under President Ronald Reagan. Since then, major priorities at DOE facilities have been health and safety, waste management, and environmental restoration.
In 1969-'70 Swedish and Canadian scientists determined that inorganic mercury released to streams could be converted to methylmercury, which is taken up by edible fish. Methylmercury in fish and other mercury compounds can cause brain and nervous system damage in humans.
In 1982, as a result of a study by Oak Ridge National Laboratory, the state of Tennessee, and later DOE, posted warnings against eating fish from Poplar Creek and East Fork Poplar Creek in Oak Ridge. The ORNL work showed that bluegill fish in EFPC had higher-than-permitted levels of mercury and that the Y-12 Plant was a continuous source of mercury to the creek.
In response to a newspaper reporter's 1982 inquiry under the Freedom of Information Act, DOE disclosed on May 17, 1983, its large historic losses of mercury (18,000 gallons out of 200,000 gallons used) to the environment. The accidental discharges came from secret lithium-separations work in support of hydrogen bomb development. President Harry Truman had announced plans to develop the H-bomb in 1950, and Y-12 Plant workers separated lithium isotopes using mercury from 1955 to 1963.
On July 11, 1983, a congressional hearing on the government's role in mercury contamination of Oak Ridge was held in the city. U.S. Reps. Al Gore and Marilyn Lloyd, both of Tennessee, were present at the hearing.
In 1985, DOE's Inspector General published "Alleged Cover-up of Mercury Contamination," a report on the DOE Oak Ridge Operations' handling of mercury contamination. In the same year, DOE started an ongoing project at Y-12 to reduce mercury in plant effluents into EFPC. As a result, biologists have been finding more fish of various species in the creek, once called an "aquatic desert."
Over the next 10 years, ORNL researchers measured the relative concentrations of different forms of mercury in Lake Reality (a spill-control impoundment built at Y-12 in 1988), in East Fork Poplar Creek and its sediments, in floodplain soil, groundwater and in air.
They also found that the deepest sediments of Lower Watts Bar Reservoir are contaminated with mercury as well as arsenic, chromium and radioactive cesium-137. Because mercury was trapped in deep sediments, scientists later determined that the contaminant of most concern for fish eaters is PCBs from industrial sources.
Researchers with Science Applications International Corp. (SAIC) and Oak Ridge Associated Universities also made a variety of mercury measurements. ORAU tested the garden soil and vegetables of residents and found no health threats.
In 1989, the Environmental Protection Agency made DOE's Oak Ridge Reservation a Superfund site, requiring it to be cleaned up to comply with the Comprehensive Environmental Response, Compensation and Liability Act. The Clinch River Environmental Restoration Program was established at ORNL to provide a scientific basis for the government's remedial plans.
In 1990 news media reports that sediments in Lower Watts Bar Reservoir are contaminated with mercury and other pollutants caused resort owners to be concerned about possible declines in the tourist trade, so they filed a successful lawsuit in 1991 against the DOE contractors. DOE agreed in September 1995 to implement institutional controls such as posting of advisories against eating the reservoir's fish, evaluating sediments for high levels of contaminants and continued environmental monitoring.
In 1993 remediation goals for mercury in East Fork Poplar Creek floodplain soils were determined. One concern was that children could get mercury poisoning from eating floodplain soil; it was assumed that a child might drop a lollipop on the soil, pick it up and lick it.
The original cleanup goal for the East Fork Poplar Creek floodplain was 50 parts (of mercury) per million (parts of soil). In other words, soils with a mercury concentration greater than 50 ppm had to be removed at an estimated cost of $370 million. This cleanup goal was based on an EPA assumption that the soil mercury was mostly mercuric chloride, a toxin easily taken up by the body's organs.
Oak Ridge researchers confirmed earlier evidence that the dominant mercury compound in the floodplain soil is mercuric sulfide, which the organs do not absorb and which readily leaves the body. Because this compound is non-toxic, DOE recommended a cleanup goal of 180 ppm.
At a January 1995 public hearing, Oak Ridge citizens argued that DOE's cleanup goal of 180 ppm for mercury in East Fork Poplar Creek floodplain soil was too conservative in light of local scientific findings. In its Record of Decision for the East Fork Poplar Creek floodplain, issued in November 1995, DOE changed its cleanup level from 180 to 400 ppm, reducing the remediation cost by hundreds of millions of dollars.
In 1996-'97 DOE's Oak Ridge Environmental Management Program supervised the removal and replacement of mercury-contaminated soil on 13 acres at two floodplain sites along Lower East Fork Poplar Creek. The total cost: $8 million.
A report issued in 1997 by Tennessee's Oak Ridge Health Project concluded that this significant Cold War pollution event posed no threat to public health. The highest risk from methylmercury was to the unborn children of pregnant women who ate large amounts of fish from the Clinch River and Poplar Creek in the 1950s and 1960s. That's when Y-12 mercury releases were the highest and when mercury was not thought to be a health hazard in waterways.
In the past 16 years, Y-12 has continued to reduce mercury discharges to East Fork Poplar Creek. In early May, U.S. Sen. Lamar Alexander, R-Tenn., announced that a water treatment plant will be built at the head of East Fork Poplar Creek to prevent future releases of mercury to the creek. East Fork Poplar Creek is currently a test bed for ORNL studies of mercury, fish and the roles of different bacteria in increasing or decreasing methylmercury concentrations in water.
Thank you Carolyn for your review of the mercury issue and the details surrounding the investigation and reporting of the issues related to mercury in East Fork Poplar Creek.


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Siblings Addison and Liza are on the run from a casino heist gone wrong. When a car accident leaves their wheel man and a state trooper dead, they split up and make a run for the Canadian border in the worst of circumstances - a near whiteout blizzard. While Addison heads cross-country, creating mayhem in his wake, Liza is picked up by...
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Siblings Addison and Liza are on the run from a casino heist gone wrong. When a car accident leaves their wheel man and a state trooper dead, they split up and make a run for the Canadian border in the worst of circumstances - a near whiteout blizzard. While Addison heads cross-country, creating mayhem in his wake, Liza is picked up by ex-boxer Jay, en-route for a Thanksgiving homecoming with his parents, June and retired sheriff Chet. It's there the siblings are reunited in a terse and thrilling showdown that pushes the bonds of family to the limit.
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A modern day Western noir about the uniquely American tendency to find redemption and resolution through violence, Deadfall holds magnificent promise. So much promise that at all times, even during the plodding first hour of its 95 minute runtime that's devoted entirely to talky exposition, you keep thinking that it'll pay off. That never happens, and what we're left with is little more than an atmospheric mood piece populated by thinly sketched characters who seem primarily concerned with articulating the film's themes. Lest you should be so thick as to otherwise miss them, of course.
Deadfall, directed by Austrian emigré Stefan Ruzowitsky, previously best known for the 2007 Academy Award winner for Best Foreign Language Film, The Counterfeiters, presents a triptych of dysfunctional parent-child relationships (or, rather, guardian-child relationships) in the guise of a thriller. Eric Bana and Olivia Wilde are Addison and Liza, two siblings on the run — they've just barely escaped from a botched casino heist, as the film opens — who're making their way to the Canadian border across the frozen countryside of Wisconsin or Minnesota. Though they're brother and sister, it's clear that Addison is a father figure to Liza, and that she'll do almost anything for her ''protector.'' They split up to avoid detection, and, while Addison goes on a psychotic killing spree — among his victims is the dialogue, for the otherwise excellent Bana sports the worst twang since Jon Bernthal's Walking Dead character — Liza hitchhikes a ride from Jay (Sons of Anarchy's Charlie Hunnam), an ex-boxer and silver medalist at the 2008 Beijing Olympics. Jay's just gotten out of prison after being convicted of fraud for throwing a match.
Liza is played with mercurial perfection by Wilde, who flashes those dewy saucer eyes at Jay and quickly melts his heart. She's a fallen angel who would have turned out okay if it just hadn't been for her no-good brother. That makes us root for her, sure. But it doesn't make her much more evolved or rounded a character than a Lillian Gish gamine in a D.W. Griffith movie. Hunnam, however, goes further and identifies a streak of glowering menace in Jay that makes him much more three-dimensional than the Channing Tatum-caliber ''sensitive hunk'' character that he's clearly supposed to be in the dialogue. He's hoping to make amends with his father (Kris Kristofferson), who's never forgiven him for throwing that fight, and he invites Liza to have Thanksgiving dinner with him and his family—at their house conveniently located near the border for a quick post-turkey flight into Canada.
Finally, the third parent-child relationship, between the deputy (Kate Mara) who's tracking Bana and Wilde's bandits and her father, the sheriff (Treat Williams), can be summed up in this particularly un-nutritious bit of dialogue:
Father: ''If you were one of my boys I'd hit you so f***ing hard.
Daughter: ''If I were one of your boys you'd be proud of me.''
All three of these relationships find their resolution in a genuinely suspenseful Thanksgiving dinner standoff and, finally, shootout. But the neatness with which these conflicts are resolved proves that this film's script, penned by first-time (and it shows) screenwriter Zach Dean, contains a diagram more than a plot. No matter how hard this outstanding ensemble of actors may try, they can't bring these characters to flesh-and-blood life. Which is a shame because Ruzowitsky otherwise has such a command of this material. His photography of a frozen, rural Midwest may be the most vividly realized depiction of snow, of the sheer sensation of cold, since Courtney Hunt's remarkable Frozen River in 2008. Ruzowitsky uses landscape to enhance his lonely characters' isolation, but ultimately we're the ones who walk away feeling cold.
Hollywood.com rated this film 2 1/2 stars.
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An eastern Boulder County lawmaker's bid to reduce what he's said are potential conflicts of interests on the part of some Colorado Oil and Gas Conservation Commission members cleared its first state legislative hurdle on Thursday.
House Transportation and Energy Committee members voted 7-5 to approve Lafayette Democratic Rep. Mike Foote's proposal to prohibit people from being employees, officers, directors of or operators of oil and gas companies while serving on the Colorado Oil and Gas Conservation Commission, the state agency that regulates and oversees oil and gas exploration and production.
"This bill is about restoring the public's trust in the way that we regulate oil and gas production here in the state of Colorado," Foote told committee members.
"A decision maker paid by the industry is in an inherent conflict of interest," Foote argued. He said current law, which allows people working for oil and gas operators or for oil and gas service companies to fill several of the nine-member state commission's seats contributes to "the widespread perception that the fox is guarding the hen house."
Foote said the public's distrust of the Colorado Oil and Gas Conservation Commission could be illustrated by the Longmont City Council's experience.
Foote said the Longmont council listened to its constituents' concerns about the impacts of oil and gas drilling, heard from supporters and opponents of stricter rules and ultimately adopted what council members thought were reasonable regulations. Shortly thereafter, the City Council found itself being sued -- not by the industry, but by the Oil and Gas Conservation Commission, which Foote said "stood shoulder to shoulder with the industry."
Foote's House Bill 1269, which advances to consideration by the Legislature's full 65-member House of Representatives, drew nearly two hours of testimony from dozens of witnesses during Thursday's House committee hearing.
Stan Dempsey, president of the Colorado Petroleum Association, said the Oil and Gas Conservation Commission -- which under current state law must include three members with substantial experience in the oil and gas industry -- benefits from those commissioners' experience.
Dempsey asked House committee members whether they'd eliminate people in certain occupations and professions from being able to serve on the state boards that oversee professional qualifications and conduct and state licenses. Dempsey has said that would be like barring physicians from being appointed to the Colorado Board of Medical Examiners.
But Peg Perl, a staff counsel with Colorado Ethics Watch, one of the groups and individuals supporting Foote's bill, said although newly appointed Oil and Gas Conservation Commission members could no longer be current oil and gas company employees, they could be retired employees, professors, consultants or professionals in related fields.
Bob Randall, deputy director of the Colorado Department of Natural Resources, said Gov. John Hickenlooper hasn't yet reviewed Foote's bill but that Randall's department couldn't support Foote's bill in its present form because of concerns that it "would upset the balance" achieved in 2007, when the commission's makeup and responsibilities were changed. Prior to that, the seven member commission included five people from the oil and gas industry.
Randall said if paid employees of the oil and gas industry are no longer allowed to serve on the commission, that could raise questions about other commissioners' possible conflicts with their jobs, since current state law also says that one commissioner must have training or experience in environmental or wildlife protection, that one member must have training or experience in soil conservation or reclamation, and that one member must be actively engaged in agricultural production and be an oil and gas royalties owner.
Foote's bill would also amend the commission's state-mandated mission by charging the agency with ensuring that development of oil and gas resources protects the public's health, safety and welfare, the environment, and wildlife resources.
Among those speaking for the bill at Thursday's hearing were representatives of: Our Health, Our Future, Our Longmont; Colorado Common Cause; Clean Energy Action; New Era Colorado: and Be The Change. Among those speaking against it were representatives of the Colorado Oil and Gas Association, the Colorado Association of Commerce and Industry, Colorado Farm Bureau, the Colorado Cattlemen's Association, the Colorado Competitive Council and the Denver Metro Chamber of Commerce.
After the hearing, Foote said his House Bill 1269 "addresses the system, it addresses the mission of the COGCC, and it ensures accountability to increase public trust."
John Fryar can be reached at 303-684-5211 or email@example.com.


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Randstad offers a comprehensive range of HR services to our clients. We provide temporary, temporary to permanent, permanent and outsourced placement services for local and global customers and fulfill all aspects of commercial and professional staffing within Accounting & Finance, Office & Administration, Engineering, Healthcare, IT, Legal, Life Sciences, and Manufacturing & Logistics. Other offerings include payrolling, managed services, recruitment process outsourcing and HR consulting solutions.
Randstad provides skills assessments, career counseling, training, health coverage and 401(k) to eligible internal and external employees. With its 2,500 employment experts, Randstad puts an average of 50,000 people to work in the U.S. each week, through its network of more than 500 branches and client-dedicated locations.
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Latest update : 2012-10-11
End of the death penalty? (part 2)
Support for the death penalty may be on the wane worldwide but as the Arab Spring rewrites constitutions, the abolition of capital punishment is by no means a given. In France, the death penalty is long gone. However, for many, the punishment still does not fit the crime, with some of the EU's longest prison sentences.
- Eric BERNARD. Spokesperson, "Together against the Death Penalty";
- Celine BARDET. Jurist, International Criminal Law. Author, "Zone Sensible";
- Avi BITTON. Human Rights Attorney, Avi Bitton Law Firm;
- Richard C. DIETER. Executive Director, Death Penalty Information Center (from Washington).
Produced by Anelise Borges, François Picard, Mary Colombel, Christopher Davis.


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In his terrific essay on "Politics and the English Language," George Orwell observed that "(w)hen there is a gap between one's real and one's declared aims, one turns as it were instinctively to long words and exhausted idioms, like a cuttlefish spurting out ink."
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Ellen Brown, Simpsonville's tearoom proprietress, was played by adaptable actress Florence Freeman. The 14 consecutive episodes included in this set find her engagement to Dr. Anthony Loring (Ned Wever) threatened by a jealous widow.
EPISODES INCLUDE: Talk About Louise's Money 05-17-50, Louise Talks to Ellen and Madelyn 05-18-50, Ellen Picks Up Christopher 05-19-50, Madelyn and Christopher Argue 05-22-50, Ellen Receives Louise's Diary 05-23-50, Madelyn Visits Anthony 05-24-50, Should Ellen Read the Diary? 05-25-50, Anthony Tells Ellen to Read Diary 05-26-50, Anthony Confronts Louise 05-29-50, Madelyn and Christopher Marry 05-30-50, Anthony Threatens Louise 05-31-50, Ellen and Anthony Talk it Over 06-01-50, Ellen Confronts Louise 06-02-50, Ellen and Anthony Make Up 06-05-50


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I got a little excited about Jennette and jumped to her before sharing about her older brother Hugh McDonell also a son of Alexander John and Ellen (McPherson) McDonell.
Hugh was born about 1834 in Upper Canada. He married Ellen McDonald on 24 May 1858 in the St. Alphonsus church. Ellen's parents were John McDonald and Catherine McGuire.
Source: Quebec Baptisms, Marriage and Burial Indexes from the St. Alphonsus Catholic Church FHL#1029797, #M5. Also at Ancestry.com under Quebec Church Records.
They had maybe five (5) children:
- Andrew Laughlin McDonell born 4 November 1859, baptized 15 November 1859 (#B73 FHL#1029798)
- Jessy McDonell born about 1860. (This is not confirmed.)
- Ellen McDonell born 1 February 1862, baptized 11 February 1862 (#B12, FHL#1029798)
- Alexander McDonald born about 1862 and died 24 May 1877, buried 26 May 1877 (#1320, pg. 89, Cemetery Inscriptions and Burial Records book)
- Helena McDonell born about 1872 and died 6 March 1875 (#B85, pg. 24, Cemetery Inscriptions and Burial Records book).
The two strongest candidates for the children of this couple are Ellen and Alexander for they are on Nellie's chart and the chart that Elaine Brown shared with me. Andrew? was added from the St. Alphonsus Records while Jessy is a big maybe and unfortunately I cannot figure out why I have added this child? I did a lot of this work on the family ten years ago so I am having to revisit and double-check and re-source my records. So please use this as a guide.


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Readers share opinions
Obamacare was voted down party lines - no GOP vote. If this was a health care issue only, the IRS would not be so deeply involved. I can't follow your accusation that the GOP isn't into negotiation. Obama and Reid both wanted Government shutdown and by stating that, they were not giving. They got what they wanted. I am backing the GOP to stand their ground.


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The City of Rolla has reposed special trust and confidence in the knowledge, courage, integrity, and professional excellence of Reserve Officers Scott Langley/891 and Tim Boone/899.
The City of Rolla has reposed special trust and confidence in the knowledge, courage, integrity, and professional excellence of Reserve Officers Scott Langley/891 and Tim Boone/899.
In view of these qualities and their demonstrated leadership potential and dedicated service to the Rolla Police Department, they are therefore promoted to the rank of Senior Patrol Officer, effective immediately. Spo. Scott Langley and Spo.
Tim Boone joined the Rolla Police Department in November of 2006 as reserve patrolmen. Both officers serve on the Rolla Police Department SWAT team and perform countless duties throughout the year such as parade and special event details, SWAT callouts and many other services. And of course as a "reserve" officer, they perform all of these duties without pay.
Spo. Boone is currently employed by the United States Army as a civilian employee. Tim is an instructor/writer for the Military Police School at Fort Leonard Wood. Tim has been employed by the Army since 2004 and during that time, has been an instructor for SWAT and Basic Police Functions. Tim served as an active duty member so the Army from 1997 – 2004.
Spo. Langley too is a civilian employee for the US Army at Ft. Leonard Wood, where he too is a SWAT instructor. Scott has served in that capacity since October of 2003. Prior to accepting that position, Scott served on active duty in the US Army from 1995 -2003.
I would like to congratulate both of these fine officers on their promotion and thank them for their dedicated service to our community. The Rolla Police Department Reserve Unit is comprised of 11 dedicated volunteers from various walks of life who offer a wide range of experience on many levels. We truly appreciate their time, dedication and willingness to serve! Thank you for all you do.
This next entry is from the desk of Sgt. Vince Giacolone who is our Law Enforcement Torch Run coordinator for Special Olympics – Missouri. Vince writes: Tomorrow, Saturday March 9, is supposed to be a beautiful day (temps in the mid-60's), and we're sure many of you will be out and about, but please plan on spending a few minutes or more with us at our big fund raiser for Missouri Special Olympics. It's the Taste of Rolla Chili Cook-Off where you'll get a chance to vote on the best chili in Rolla. 12 restaurants will be bringing their chilies for you to vote on; $4 permits you to sample as many chilies as you like, plus a bowl of your "favorite" chili. We'll also have hot dogs, soda and ice cream to purchase as well. Silent auction, door prizes, and entertainment by the popular musical group Trilogy. Where: Eugene Northern Community Hall, 400 W. 4th St., Rolla. Time: 11 a.m.-2 p.m. Hope to see you there.
This entry is from a citizen in Rolla who writes: I just wanted to take a quick moment to extend a sincere note of gratitude to Officer Moss, along with another member of your staff whose name I did not obtain. This Sunday I called your department to request a welfare check. To make a long story short, I had received text messages from Removed that were of a questionable and concerning nature. I was worried, based on the content of these messages as well as some behavior changes over the last few months, that they might hurt them self or others.
However I didn't want to overreact, or take up an officers' time unnecessarily, so I was somewhat timid about calling. To add to the apprehension I felt, I was not sure exactly where Removed was since they recently relocated to Rolla from removed (we have not had much contact since our breakup). I knew I would be calling with nothing more than a cell phone number to help locate them. . .not much to go on at all. The lack of information I had about his current address made me hesitate.
From the moment the phone was answered, my fears were put to rest. The woman who took the call was professional and caring. She was very patient with the fact that I had no information on their current whereabouts. She was calm and made me feel more confident in my decision for calling.
My removed was eventually located, and she discontinued with me. I was incredibly impressed with how quickly I received a follow up call from Officer Moss, who told me he had already been out to check on things. He repeatedly stressed that I was not foolish for calling, and that it was the right decision. He was very professional, and made me feel so much better about contacting the department. He even encouraged me to call him directly if I received any further communication of the same nature.
My father is the police chief in removed, and has been in law enforcement for over 35 years. As a result, I have been around law enforcement my entire life. As a kid, I would often spend full days at his department during summers and school vacations. However I have never had to call the police myself, as a civilian. Finding myself suddenly in a situation where I had to was stressful and nerve wracking.
It's silly to say, but even though I have the highest opinion of police officers, I suddenly found myself worrying: will they think I am wasting their time? Will they be upset that I am calling with not much information? Will they think I am overreacting? I know your department probably handles many, many welfare checks a year, however it was my first. As far as calls go, I am sure it fell way down on Officer Moss's list of exciting calls, but he made it a top priority and handled it quickly and professionally.
I can't say how much that meant to me in an already uncomfortable and emotionally charged situation. I know all too well that due to the nature of the job, you may not always hear positive feedback, so I wanted to pass this on. Thank you again. On a side note, the telecommunicator assisting Pto. Moss was veteran telecommunicator Amy King! Great job to both of you.
This past week, Communications Supervisor Stacey Smith conducted 40 hours of telecommunicator certification training for telecommunicators from not only our own Central Communications Division, but also telecommunicators from other agencies in central Missouri. Students described the class as informative, challenging, interesting and entertaining!
The training covered information about technology, liability, call taker skills, interpersonal professionalism and much more! We are proud to report everyone passed with flying colors! Good job everyone!
In closing, I would like to mention that next week Missouri S&T will begin the annual St. Patricks Day acitivities. If you plan to participate in the many events please remember to do so safely. If you choose not to participate please use caution in and around the campus as this time of year typically inspires many more outdoor activities and student presence. And remember to set your clocks forward this Sunday in observance of daylight savings time.
Have a great week!