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Checking Out Cars? Read This Write-up Initially!
Are you presently thinking about buying a fresh automobile or truck? Are you normally not aware of the automobile industry? Are you currently afraid of obtaining conned? If these items are accurate to suit your needs, then see the guidelines in this article. They can help you get the best determination it is possible to.What can you afford? You will need to fully grasp precisely how much dollars you possess on a monthly basis not only to buy the auto rent, but in addition insurance policy, certification charges, fuel, and maintenance. Almost everything should be taken care of each and every four weeks if not you'll ought to reduce the quantity you ought to spend on the vehicle on its own.Go to your nearby bank and acquire pre-accredited for a car loan. This particular one stage are not able to only help save you lots of time at car dealership, but it will save you money most of the time. By getting a loan at your financial institution, it is possible to make a deal your rate of interest better hence, reducing your overall transaction.By no means invest in a car on the initially obtain towards the showroom. Each and every auto seller will try to help you get just to walk out with a brand new set of keys at your fingertips. While this may be luring, understand that this really is a huge purchase. Take some time shopping around and make certain that the offer you're being offered is actually the best choice for you.Never keep your car with the dealership overnight. Numerous dealerships are able to offer the opportunity to go ahead and take automobile that you are thinking of property in order to analyze travel it for a longer time. While this is surely desirable, it essentially signifies they may be provided the chance to support the auto you own hostage. It is then more difficult to walk from an unsatisfactory offer, and is particularly not to your great advantage.Should you be in the market for a pre-owned automobile, a terrific way to know if the speedometer is correct is to check out the fuel and brake pedals. When someone affirms the automobile has 30,000 kilometers onto it, and the braking system and gasoline pedals are worn, it really is a very good indicator the odometer was converted rear.Do your research even before you stage feet on the vehicle lot. You need to have an well-informed situation when it comes to this type of big purchase. It is a great idea to be aware what types you are looking at, and what the reasonable price is for these particular automobiles.Look online for benefits around the car you desire. A lot of vehicle suppliers offer money again or unique credit on his or her automobiles. The dealership is not going to usually share with you this stuff up front. Spend some time to educate your self initial so you can get the hottest deal once you are within the showroom.Make sure that when you are auto store shopping you are aware what you're searching for initial. Contact all around to several of the dealerships and discover if they have something you'd be interested in. You can even locate their website to check out the autos before spending some time increasing there.Need to have a security document and automobile record document from the dealer. Anything good car dealer will have these materials readily available for any automobile in the good deal. This really is information that will show you how risk-free the automobile is along with any main accidents or work which has been required about the automobile.If you are searching to acquire a pre-owned vehicle, it is extremely important you get a duplicate of your motor vehicle routine maintenance and maintenance background. This will help you to see what has been carried out to the vehicle, and in case it has been in almost any significant incidents.Even if a vehicle is in your cost range, make sure you look at the fuel useage and twelve-monthly upkeep costs that will come with your purchase. Many individuals buy automobiles which they think are inexpensive, but afterwards they regret it once they see how very much they should pay annually for gasoline and program servicing.Investigate the resale worth of the vehicle you are interested in. In this way, when the time comes to offer the automobile you are purchasing, it will be easy to acquire a good sum of money back from it. You may not wish to turn out stuck with an auto as you owe more than you can sell it off for.If you are planning on utilizing your existing automobile as a industry in, don't let the dealership know straight away. The initial aim is always to discuss lower the buying price of the automobile you wish to buy. Information and facts like industry-in benefit is beneficial to the salesperson, so keep it to your self before the proper moment!You can purchase a vehicle on-line, bypassing the car dealership and allowing you to stay away from high-tension revenue tactics. This can be even feasible for new autos on some loads, so seek information and find the vehicle you want. Clearly, you won't be able to have a test push when you never ever visit the great deal, however.Vehicle buying organizations are a fun way to hold costs down when preventing the car dealership at the same time. This can be one strategy which enables you get a wonderful auto at a affordable price without having any sales rep inhaling downward your neck area. You can learn more about night clubs available to you on the internet.Don't at any time accept salesmen or any other folks in the dealer speaking right down to you. If this takes place, acquire your small business someplace else. You can expect to by no means obtain the best package when you don't have got a salesperson that will listen to your preferences. There will be a single around, so go locate them.Check out nearby auto displays as you're thinking about what to acquire. These enable you to examine every in . from the latest models, although you can't examination drive them. Also you can speak to the specialists on hand which will usually learn more compared to sales staff in the dealership's whole lot whenever you pay a visit to.Don't forget about these tips when you are out shopping for a car or van. Additionally they relate to larger sized vehicles like Sports utility vehicles. Armed with the correct details, you don't be concerned about creating a terrible getting choice. Appreciate each and every minute with your new vehicle with the help of this short article.crecer el pene


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Actors Park Yuchun and Shin Se-kyung introduced 'The Girl Who Sees Smells' coffee.
On April 7, SBS Wed-Thur drama special 'The Girl Who Sees Smells' production crew released photos taken of the filming appearances of Park Yuchun and Shin Se-kyung.
Their appearances are that of Park Yuchun as Mugak and Shin Se-kyung as Cho-rim are holding up the coffee from 'The Girl Who Sees Smells'(shortened, 'TGWSS') in the photos.
This coffee is the promotional coffee released by the production crew with the start of the drama. It is actually on sale in SBS office building. Thanks to the title branded on the cup holders, it made its debut shown on the 'Cultwo Show' the past March 30 at the same time with Park Yuchun, Shin Se-kyung, Namgoong Min and Yoon Jin-seo; and became the 'TGWSS' coffee.
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subset: commoncrawl


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How to Have a Casino Experience without Leaving Your Home
If you are looking for a way to have a casino experience without leaving your home, you should consider trying an online casino. There are a variety of different platforms like sbobet mobile which will let you play casino games over the internet for real money. Players on sbobet mobile are making considerable sums of money playing the various online games and you could be winning money to.
Getting Started
In order to start winning cold hard cash, you need to sign up and create an account. The account creation is fairly simple but, yes there is a "but" you will need to fund your account with cash. Some of the online gambling platforms prefer to have money wired to your account, you will need to get the wiring instructions and follow them. Once the funds have reached your account, you can start playing for real cash.
Finding Games that Pay the Most
This part of the exercise will take a fair amount of time. You will need to use your practice account to determine which games pay you the most. Each person has a particular game they are really strong at playing, what you have to do is determine which game you are the best at, this step does take time but it is worth the effort when you are rolling in the dough. Try to give preference to games where you are going up against human competitors. If you were plying against a robot, it will always be consistent which can work against you over the long-term. When dealing with a human competitor, they could let their emotions get the better of them and make a wrong play that would give you the advantage. These are just some of the things you would need to consider when trying to give yourself the best chances of success.
After you have worked out which games are going to pay the most, you should try to get your friends to play with you. One of the exciting aspects of going to a casino is enjoying the games with your friends. By having your friends sign up for an account, they will be able to have fun with you plus make some money in the process.
Making the Most of Your Online Gambling Experience
If you are trying to make some serious money from the online casino, you have to develop your strategy. Play the games that statistically have the best odds of winning, if you are playing against a human competitor then the odds vary because each opponent is different. A golden rule to keep in mind when you are playing any online game, the house always wins but if you are consistent you can come out on-top. Without a strategy, you will not be able to determine whether you should stop playing or continue.
By playing online, you are able to have a casino experience without having to deal with the hassle of traveling to the casino, so you should sign up as soon as you can.


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Client`s Objective
Develop a sales network in North America. Client already had an importer.
Analysis of the North American market. Re-branding. Develop new product line and price list.
- Determine sale channels, pricing strategy and marketing tools.
- Develop new logo, name, design and corporate history for North America
- Develop 3 new lines of business, private label and ingredients.
- Opened an American subsidiary, fully managed by Nuove Sales.
- Private label products sold nationally to various high-end supermarket chains.
- Nuove Sales also managed the sales of the client's branded products, sold in numerous national supermarkets.


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Brink's 'Memorial' premieres at the Adelaide Festival as acknowledgement of the Centenary of Armistice Day
In all senses, Memorial from SA theatre company Brink Productions (to be performed at Adelaide's Dunstan Playhouse from March 1-6), is a winding back to the fundamentals of storytelling. At its core sit two very ancient forms of the craft. The first is one of our earliest seminal stories – Homer's Iliad. In 2011, theRead More


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"Computational Identification of Tissue-Specific Splicing Regulatory Elements in Human Genes from RNA-Seq Data", PLOS ONE, vol. 11, pp. 18 pages, 2016.
"CoSREM: A Graph Mining Algorithm for the Discovery of Combinatorial Splicing Regulatory Elements", BMC Bioinformatics, vol. 16, pp. 15 pages, 2015.
"Identifying Splicing Regulatory Elements with de Bruijn Graphs", Journal of Computational Biology, vol. 21, pp. 880-897, 2014.
"A System to Automatically Classify and Name Any Individual Genome-Sequenced Organism Independently of Current Biological Classification and Nomenclature", PLOS ONE, vol. 9, pp. 12 pages, 2014.


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Leased | Unit | 2/16 Chidlow Street, Northam WA 6401 | $240 per week
Available NOW. Two bedroom, one bathroom very neat and tidy unit! Featuring open kitchen and living space, split system air conditioning, ground floor unit, private balcony, electric hot water, close to town center and train station. Book your inspection today!
This property is proudly listed by:
First National Real Estate Hollett & Lawrance
205 Fitzgerald Street
Northam WA 6401
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Property Type Unit
Property ID 21866110120
Street Address 2/16 Chidlow Street
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Price $240 per week
Bond $960
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Come on then let's get this over with; The Artist Formerly known as Thacker?
Yep, I met him teaching at CEC a few years ago. He left but we kept in touch. He started working on creating a proper English book for Thai people because the standard of English books for Thai people are terrible at best! He got his head down and worked his A*** off. Including completely immersing himself into Thai culture. Most English speaking people here speak mickey mouse Thai but his Thai is fluent, and i mean fluent. And he's done well for himself he's producing youtube videos for Thai people. Things are finally looking up for him at the moment and he deserves every bit of success he gets
Oh god you're not going to… What's it called… The thing that goes into an electric socket?
A plug? You're damn right i'm going to give him a plug (not that he needs it he already has 5000 likes on his facebook page)
He contacted me on F2thaAcebook asking if i wanted to play football last Friday. I thought "Why not?" I hadn't played in a few years and it's only a bit of fun. Maybe i could sneak a goal or two, and it'd be good exercise.
How did you do? Did you score?
Of course not, I got ripped to pieces! Thai people play at a very high tempo so even if i was at my best i would have been struggling. After 3 minutes of running after shadows i strategically decided to play centre back. Let's put it this way i now remember why i said i was retiring from football a few years ago. I was teaching the next day and i could barely breathe! i think i need to do more exercise…
Speaking of teaching, you got any teaching stories this week?
I got 2! The first one i was sitting at my desk preparing for a class when some random Thai woman walked in with a massive smile on her smile. I remember thinking "I don't know what is going to happen, but i'm pretty sure this is gonna go in my blog…"
"Hello teacher Lewis!" She beamed gesturing to her right as if she was about to introduce someone (there were only us two in the classroom) "This is your student!" She said still smiling
"No, that is a wall…." I thought to myself. Eventually i found out that she meant the student was in reception but the damage had already been done, sorry random receptionist…
And the second one?
I'm teaching a TOEIC class, and it's as boring as it sounds. There are 2 students in my class; A French girl whose English is really good and a Thai girl who can barely say her own name, it's a sitcom waiting to happen…. Anyway, I was going through one of the questions with the Thai girl and she was looking at her book ignoring me. So i started to sing " You're like a belly dancer. I give you the question, you give me the answer, police saying freeze… DA-DOING-DOING-DOING!" I don't know what possessed me to do that but it made the French girl laugh so at least it wasn't a wasted reference…
What is a French girl doing learning English in Thailand?
She wants to teach kindergartners here and wants a high TOEIC score so she can prove to potential employers that she can speak English. Unfortunately for me she is very European so she questions every little thing i say and never gives me a break.
Sounds brutal..
Actually i love it! She keeps me on my toes and i don't feel like i'm just going through the motions like i do with some classes. I came here because i want to help people and if someone has the same passion as i do i can bounce off of it. This may seem hard to believe for anyone that knows me but i do genuinely care. Its just when i get rich kids who don't want to learn i think "If you're not gonna try then neither am i…"
I suppose now i have to ask you about the book. You finished it yet?
Not yet, so carrying on from last week she was feeling remorse about what happened to Old Bill (the character who died) and she knew something about his death that she couldn't tell anyone, which in turn meant there was more of a burden on her shoulders because she had to hide her true identity from people as well. This weighed heavier and heavier on her until she finally cracked and told her boyfriend who she really was
How did he react?
He kicked her out. He also told her that if she ever came back he would tell everyone who she was. So it was an ultimate rejection. She pleaded with him for a while but eventually left. Then she fled the country to Holland where she is spending lots of money (the money that she won) on drugs and prostitutes, men and women. She's starting to feel those psychotic emotions again such as a repeatedly humming or singing a creepy song she wrote. The same one she sung to the girl as she was killing her. So we're getting closer to the end now, i'd say i'm about 70% or more through this one
So are you done? Can i go back to my life now?
Nearly. I've re-done my 'Home' and 'About' pages. My friend Clayton (who is also a blogger) helped me set it up which is why it says it is Clayton authenticated. I've also done some blurb pages for my books as well so my blog is slowly filling up with random stuff, and that's me done for this week, tune in next week when i….. ah, I've got nothing…
A picture of us at a school Christmas show. The Artist Formerly Known As Thacker is on the back row, far right, in the black shirt.


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Probability Distribution Essay
Example Suppose you flip a coin two times. This simple statistical experiment can have four possible outcomes: HH, HT, TH, and TT. Now, let the random variable X represent the number of Heads that result from this experiment. The random variable X can only take on the values 0, 1, or 2, so it is a discrete random variable Binomial Probability Function: it is a discrete distribution. The distribution is done when the results are not ranged along a wide range, but are actually binomial such as yes/no. This is used frequently in quality control, reliability, survey sampling, and other corporate and industrial situations. This type of distribution can measure levels of performance only if the results can be placed into a binomial order, such as with a point estimate where only one number is relied upon. For example, if you measure whether unit X had exceeded its monthly energy limits usage and is interested in a yes or no answer. This type of distribution gives the probability of an exact number of successes in independent trials (n), when the probability of success (p) on single trial is a constant. The probability of getting exactly r success in n trials, with the probability of success on a single trial being p is: P(r) (r successes in n trials) = nCr . pr . (1- p)(n-r) = n! / [r!(n-r)!] . [pr . (1- p)(n-r)]. Continuous Distributions: -Continuous probability functions are defined for an infinite number of points over a continuous interval. .
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Northwest Region Home Fire Campaign
Your help is needed to reduce death and injury from home fires by 25%.
American Red Cross Home Fire Campaign
Do You Need A Smoke Alarm?
Together we installed 1 million smoke alarms – a major milestone achieved!
Thank you to the thousands of volunteers that joined us to Sound the Alarm to install 100,000 free smoke alarms in at-risk communities across more than 100 cities. Together, we're saving lives!
Help save lives in your community.
Every day, seven people die in home fires, most in homes that lack working smoke alarms. Sadly, children and the elderly disproportionately lose their lives. The American Red Cross wants to improve the odds and save lives, that's why we launched our Home Fire Campaign in 2014.
A critical part of the campaign is Sound the Alarm, a series of home fire safety and smoke alarm installation events across the country. Red Cross volunteers, along with fire departments and other partners canvass at-risk neighborhoods, installing free smoke alarms, replacing batteries in existing alarms, and providing fire prevention and safety education. In just three years, we've accomplished so much, including the installation of more than 1 million smoke alarms and prepared more than 1 million people against home fires through our home visits.
Get InvolvedThere are several ways you can get involved with Sound the Alarm:
The Red Cross Responds to a Home Fire or Other Disaster Every 8 Minutes.In the Northwest region, the Red Cross and its partners have:
A Local Story From People Helped by the Home Fire Campaign
On October 24, 18 Red Cross volunteers and firefighters dispersed in three Kent communities to install smoke alarms, replace batteries and raise home fire safety awareness. The work was important for the community, and rewarding for the teams. "It was fun to see how much everyone enjoyed the work," said AmeriCorps member Kayla Ihrig. "Instead of leaving early at the end of the day, people were playing games with the kids that came out to see the fire trucks. It was a great show of community." The teams installed 179 alarms, many in homes otherwise had none. "We were surprised to find in one residential establishment, every home was without a working alarm," said Allison Dedonato, Regional Preparedness Manager. "It was a real eye-opener."
Thank You To Our Sound The Alarm National Sponsors
Other Ways To Help
1. Volunteer
Canvass neighborhoods, install smoke alarms, and help residents make safety plans.
3. Donate
Prepare, respond and help families recover from home fires.
Donate Now
1. The Red Cross and its partners will install a limited number of free smoke alarms for those who cannot afford to purchase smoke alarms or for those who are physically unable to install a smoke alarm.
2. The Red Cross installs a limited number of specialized bedside alarms for individuals who are deaf or hard-of-hearing.
3. A number of organizations are partnering with the Red Cross to accomplish the goals of our Home Fire Campaign. Depending on where you live and other factors, it is possible that we will forward your request to one of our partner organizations so they can contact you to set up an appointment.
4. The Northwest region provides installation services in their region only. If you live outside of this area and would like to identify your local region office, please visit RedCross.org (or call 1-800-REDCROSS).
5. If you are able to purchase and install your own smoke alarm, but would like information on home fire safety and smoke alarm installation, please visit redcross.org/homefire


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Friday Opening Round Play of the Year leads big Tournament Card with Early 5*- 17-0 Afternoon 5* + 100% NBA Blowout and 15-1 Totals System. NCAAB 20 Games over .500 on the season. Free NBA Totals System Below
On Friday the Free NBA Totals System Play is on the Under in the Detroit at Miami game. Rotation numbers 807/808 at 7:35 eastern. This game fits a nice totals system that has won 9 of the last 10 times and plays to the under for home favorites with 1 day of rest like Miami that are favored by 10 or more with a total of 190 or higher if they were road favorites of 10 or more. The Pistons are well rested here and have 3 days off.


text: I've spent most of this evening trying to get my new theme up and running. Not quite there, but it's looking much better. Please check out my About Me page and Like Me page on Facebook. I also want to make sure that I've read your About page and Like You too since I love reading your blogs whenever I get the chance. And please, keep those blogs coming.


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Author Affiliations
Clonal hematopoiesis is a key feature of myeloproliferative neoplasms (MPN), a hematopoietic stem cell disorder comprising three disease entities: polycythemia vera (PV), essential thrombocytosis (ET) and primary myelofibrosis (PMF). Although the clinical characteristics of these three diseases are quite distinct, they do share genetic mutations that drive clonal myeloproliferation, which is their common defining feature. Continual technological advances have led to the identification of increasing numbers of genetic defects in MPN patients. In this issue of Haematologica, Stegelmann et al.1 present their results from a genome-wide single-nucleotide polymorphism (SNP) profiling study in a large cohort of MPN patients that significantly furthers our understanding of the molecular causes and diversity of MPN.
Genetic defects driving clonality in myeloproliferative neoplasms
The identification of activating mutations in the gene coding for the tyrosine kinase JAK2 (JAK2-V617F and JAK2 exon 12 mutations) in almost all PV patients and in a large percentage of ET and PMF patients,2–7 led to a series of follow-up studies to investigate their functional consequences.8 Nevertheless, how a single mutation can contribute to the pathogenesis of three phenotypically distinct disease entities is still largely unclear. One study, using a JAK2-V617F transgenic mouse model, suggested that the disease phenotype could be determined by the ratio of mutant JAK2 to wild-type protein.9 However, there is growing evidence for a more complex mechanism of MPN phenotype initiation. Observations of strain-specific differences in JAK2-V617F-associated disease phenotypes between Balb/c and C57Bl/6 mice suggest an involvement of germ line features in the resultant phenotype.8 However, besides JAK2 mutations and other oncogenic events targeting the JAK-STAT pathway (such as mutations in the MPL gene, coding for the thrombopoietin receptor and truncations of the erythropoietin receptor),8 there are still many uncharacterized somatic cytogenetic lesions present within the MPN clone, harboring a series of candidates for both the induction of clonal expansion and the MPN phenotype decision.
TET2 and CBL mutations in myeloproliferative neoplasms
Classical cytogenetic methods made it possible to detect large genetic aberrations in patients with specific diseases which revealed cytogenetic lesions usually containing a large number of genes. Recurrent defects found in MPN, such as the deletions on chromosome 20q (del20q) and 13q (del13q), are thought to harbor important tumor suppressors, the majority of which must still be identified.8, 10 The development of microarray based methods has allowed the high resolution screening of a large number of patients for the detection of somatic chromosomal aberrations. Detection of loss of heterozygosity (LOH) by microarray genotyping has become a valuable tool in cancer biology. Additional probes on the array for measuring the abundance of gene copies can discriminate between a deletion or a copy number neutral acquired uniparental disomy (UPD), underlying the LOH. Recently, microarray based mapping of the recurrent UPDs and deletions on chromosomes 4q and 11q led to the discovery of TET2 and CBL mutations being involved in the pathogenesis of various myeloid malignancies.11,12 In MPN, TET2 is mutated in about 13% of all cases with the highest frequency in PMF (17%), followed by PV (16%) and ET (5%).11, 13 Stem cells carrying TET2 mutations have been shown to exhibit a proliferative advantage in a murine competitive repopulation model.14 Although the mechanism of action of TET2 is not known, it may involve epigenetic gene regulation, as another Ten-Eleven-Translocation family member, TET1 has been shown to catalyze the conversion of 5-methylcytosine in DNA to 5-hydroxymethylcytosine.15 In contrast to TET2, the function of the E3 ubiquitin ligase CBL in hematopoiesis seems to be clearer, as CBL is involved in the ubiquitylation of factors important for tyrosine kinase function, specifically influencing STAT5 phosphorylation.16 Tyrosine kinase signaling is tightly regulated not only by dephosphorylation, but also by degradation of receptors and signaling molecules. Interaction studies revealed a role of CBL in ubiquitylation of the cytokine receptors Epo-R and c-Kit, various tyrosine kinases (e.g. Jak2, Tyk2, Abl) and adapter proteins important for cytokine signaling such as Grb2.17 CBL shows clear properties of a classical tumor suppressor, such as increased proliferative response due to loss of function in both the homo- and heterozygous state. Nevertheless, CBL mutants were shown to have gain-of-function properties in the absence of wild-type CBL, augmenting the cytokine hypersensitivity of the loss-of-function phenotype to a broader spectrum of cytokines.16 Therefore, CBL was proposed to be a tumor suppressor with features of an oncogene, regulating the degradation of pleiotropic factors (Figure 1).
Inactivation of NF1 in myeloproliferative neoplasms
In this issue of Haematologica, Stegelmann et al.1 present the results of a screen for somatic genetic lesions in a cohort of 151 MPN patients using 250K SNP arrays. Genotyping 250,000 SNPs distributed throughout the genome gives sufficient resolution for identifying even single gene defects. Applying an unbiased approach on patient selection, Stegelmann et al.1 could detect copy number altering genetic defects (deletions, gains) at frequencies spanning from 15% in PV to 62% in post-PV myelofibrosis (MF). The frequencies of copy number neutral UPDs in their cohort were similar (14% in PV up to 62% in post-PV MF). Beyond the most frequent aberrations, the previously described and well known 9pUPD and del20q aberrations were detected. Most of the genetic lesions identified spanned large regions containing several genes. In 2 patients, microdeletions on 17q could be detected, exclusively targeting the NF1 gene. Sequencing of the remaining NF1 allele revealed a mutation in one of the 2 cases, suggesting that clonal expansion can be induced by haploin-sufficiency of NF1 as well as full inactivation. NF1 mutations are also found in Von Recklinghausen's disease (also known as Neurofibromatosis type 1), where both germ line and spontaneous mutations cause various tumors, primarily in the peripheral nerve system.18 The NF1 gene codes for neurofibromin, a GTPase activating protein that inactivates the small GTPase Ras by accelerating Ras-associated hydrolysis of guanosine triphosphate (GTP) into guanosine diphosphate (GDP) and phosphate (Figure 1).19 Loss of NF1 causes Ras to remain in its active state (bound to GTP) stimulating induction-independent cell proliferation.19 Ras is an important signaling molecule within the mitogen-activated protein kinase (MAPK) pathway, a pathway triggered by various cytokines. Of specific relevance to hematologic diseases is the involvement of Ras in granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling, which promotes survival of myeloid cells, and an NF1 knockout mouse model has been shown to develop an MPN phenotype.20 From the 2 cases reported by Stegelmann et al.,1 one wild-type, the other homozygous for JAK2-V617F, NF1 loss is likely to give additional growth potential even to cells homozygous for JAK2-V617F, but it is acquired independently from the JAK2 mutational status. Furthermore, both patients progressed to secondary myelofibrosis, one from ET and the other from PV, whereas the latter finally transformed to acute myeloid leukemia. Whether NF1 plays a role in this transformation needs further investigation, although the occurrence of NF1 mutations in various childhood (up to 15% in juvenile myelomonocytic leukemia (JMML)) and adult leukemias is suggests that it does.21
Relationship between the different genetic defects in myeloproliferative neoplasms
Due to the rapid evolvement of microarray and next generation sequencing technology, abundant information on defects involved in MPN pathogenesis will soon be available. In principle, it will then be possible to draw a map of genetic aberrations for each patient. Important information necessary for drawing such a map is the acquisition order and clonal relationship of genetic lesions. This can be determined by looking at mutational burdens in isolated cell types, or by genotyping single colony forming hematopoietic progenitor cells for the known defects.8, 22–25 Currently, only a few conclusions can be drawn on the relatedness and acquisition of the genetic defects in MPN. First, the oncogenic mutations in JAK2 and MPL have not been observed combined in a single clone. Second, the most frequent cytogenetic aberrations, del20q and del13q have been observed in the same patient, but only in different clones. 22–25 Concerning the order of acquisition of the defects identified to date, there is increasing evidence that there is no predefined acquisition order of these lesions for MPN.8 For the recently discovered mutations in CBL, TET2 and NF1, TET2 mutations tend to be acquired rather early in the disease course, whereas CBL and NF1 might be late events, eventually being involved in leukemic transformation. TET2 has been observed to be acquired both before and after JAK2-V617F,11,26,27 whereas CBL has been observed preferentially in the absence of the classical oncogenic mutations or succeeding JAK2-V617F,16,28 similar to the data on NF1 provided by Stegelmann et al.1 Furthermore, there is some evidence that both CBL and NF1 mutations are associated with leukemic transformation, however this needs to be confirmed in larger studies. Specific mutational analysis of progenitor colonies on a larger scale is required to place TET2, CBL and NF1 into the clonal hierarchy of the progenitor pool to determine whether they integrate into the model of random mutation acquisition.
Evidence for a "mutator" phenotype in myeloproliferative neoplasms
The large amount of cytogenetic aberrations detected in MPN clearly points to the existence of a "mutator" phenotype in MPN pathogenesis. Chromosomal instability might be triggered by known defects, or by as yet unidentified mutations. These unknown somatic or germ line mutator defects could affect non-protein coding sequences or epigenetic factors. Evidence supporting an inherited predisposition to acquire specific mutations was recently provided by the identification of a JAK2 gene haplotype that confers susceptibility to JAK2-V617F and JAK2 exon 12 mutation positive MPN.22,29–31 Since this "GGCC" haplo-type (also known as 46/1) has a relatively low penetrance, additional somatic and germ line mutator defects are expected to be at work in MPN.
The recent findings of new somatic mutations and the first insights into elements predisposing for MPN represent big steps in the field, but render the picture of the underlying cause of MPN even more complex. More mutations are predicted to be identified as the resolution of cytogenetic analysis increases, as well as by broad application of next generation sequencing. Additionally, increased feature density on microarrays succeeding the 250K technology has opened up the possibility for whole genome association studies, with the potential to reveal even more important genetic loci in MPN pathogenesis. The construction of a comprehensive network of all the disease-contributing defects is one of the predominant but now seemingly realistic future challenges in MPN genetics.
Roland Jäger, M.Sc., is currently in his final year of training within the PhD Program of the Center for Molecular Medicine in Vienna, Austria. Dr. Robert Kralovics is an independent Principal Investigator at the Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
No potential conflicts of interests relevant to this article were reported.
The work was supported by grants from the Austrian Science Fund (FWF) and the MPD Foundation.
- Copyright© Ferrata Storti Foundation


text: Whatever happened to the thousands of illegal immigrants children that were part of isis that we heard about last year? Whatever happened to the guy from seventh heaven? Why don't we hear Ebola stories anymore??? February 7, 2015 · by thehoustonsocialbutterfly · in HOUSTONS SOCIAL SCENE. · via Facebook Advertisements Share this:FacebookTwitterPinterestTumblrLinkedInEmailPrintMoreRedditGoogleLike this:Like Loading... Related


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Iona Senior Services, St. Alban's Wellness Center, is a place that I call home. Starting as an eager volunteer, Iona made me appreciate the community to a larger aspect. I learned that volunteering should not be for the resume, but how an individual can impact the community holistically. Many students in the millennial generation tend to perceive community service as a necessity for the resume, trending with the white-savior complex; however, it is much more than that. At Iona, I assisted the elderly wellness center with approximately 30 participants daily through interactive activities such as cultural and health dialogue, while also distributing meals, conversing with the participants, and designing a program day for seniors to share skills with college students in order to entice memory and social wellness.
Throughout this experience, I made close ties with the senior participants at the center. In fact, several of them expressed their personal issues with me as I came in every week, which was quite interesting from my perspective. I learned how their community functioned, specifically their everyday lifestyles ranging from living alone to having relatives that work during the day. Though, a commonality stood as the need to socialize with others in order to maintain a healthy lifestyle. This social factor was incredibly important to seniors, which I did not realize in the past. This was the pinnacle concept to understanding my purpose at Iona – to communicate with seniors in order to enhance their insights of everyday life. As a young college student, I have the ability to connect with participants through my youthful experiences, academic interests, and personal life in order to bring them joy. Sometimes my experiences remind them of their own youthful days, which result in rewarding stories of their identities. While I have the ability to retrieve stories from participants, they reminisce on their younger days, and provide advice. In fact, one man gave me love advice specifically saying, "you may have a lot of small fires in your life, but you have to wait for your biggest flame".
Apart from my experiences with the seniors, the staff dynamic at Iona is a humble welcome to anyone that steps in the building. Personally, I have a close relationship with the program director, Courtney Tolbert, where we form dialogues about race, gender, and age disparities. Some issues we talk about are implemented into the Wellness Center Program, such as cultural activities and race dialogues. It is important to be aware of current issues and to have dialogue about them in order to entice critical thinking, especially for seniors who may be entranced in traditional ways. As a program director, Courtney creates a friendly dynamic with the volunteers, a leadership style that persists on relationship building for community growth. This benefits the seniors due to the friendly environment that they are surrounded with.
As a result, my time volunteering with Iona Senior Services matured my approach on volunteerism. In an internship-centered environment, it is important to understand that volunteerism is not about the hours or resume, but about the personal passion that advances the community's needs.


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Resurrection Day; Sixty::Seventeen
By ~ Patricia
Category: Holy Week, Lent/Easter, Savoring Sweet Sixty
"Our Lord has written the promise of the resurrection, not in books alone, but in every leaf in spring-time."
~ Martin Luther
Photo: Goldfinch in Sweetgum Tree, March 2008.
5 Responses to "Resurrection Day; Sixty::Seventeen"
Sweet picture of the goldfinch! Hope you are having a wonderful Resurrection Day.
Happy Resurrection Day Patricia! I hope you had a beautiful day!
Oh how true.I am so thankful that our God has shown us His love by rising from the dead. Blessings,Ruth
Sweet pic – Happy Resurrection Day Pat!
This is a great post – what a sweet truth! Praise the Lord for the sure hope that we have in Him.


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|Viewing Single Post From: This Isn't My Home, It's Where I'm Locked Away
|Aug 17 2016, 12:44 AM
maybe if you're lucky the random avatar will sync up to the character you're reading right now
Min-Jae was still there. In front of him. He had stepped back slightly but Alvaro could still see him and he was still holding the baton and both of them were still on an island with collars around their necks and in a game where the aim was to be the last person still alive. He had to do something. He didn't know what but he knew he couldn't just stand here but he didn't know what and his body wasn't moving and min-jae was right in front of him. This was a mistake. Min-Jae was going to be a bad guy. Alvaro knew that was going to happen. He acted angry to everyone and Alvaro knew that in particular he hated him. His hands were shaking. Something. Something.
He remembered back to before he woke up when the man was speaking on the podium. He had to look around him. Anyone could kill him. He could have to kill anyone to survive. He had to either be dead or do something. He knew that he didn't want to be the former, but he knew that he didn't want to do the latter, either, but min-Jae was right in front of him, he had to do something. Anything. Anything that would get him out of here alive.
Min-Jae touched him with the stick. Alvaro's body jolted.
The foot went up.
|This Isn't My Home, It's Where I'm Locked Away · Regular Wards


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I'm not a Londoner, but, when analysing the Green Party's message ahead of the London mayoral and assembly elections, I think this puts me in a better position. I don't have to face the prospect of Boris or Ken managing my locality for the foreseeable future.
The video below, 'Make the Difference', is the main Green Party Election Broadcast for the elections on 3rd May. It's a youthful take on the standard Green policies, but is it a viable set of proposals for London? Is there really a chance for a Green breakthrough?
Mayoral candidate Jenny Jones sees the two prongs of the Green Party as environmentalism and social justice, and these themes are put forward prominently. Using children to provide the message of 'We can't vote, but you can', is not just a heart string-jerker, but emphasises how the environmental problems we face might not effect our daily lives now, but could be severely damaging in the future.
There is a predictable strong green (deliberate lowercase) message in the video. The kids recount plans for more trains, bikes and lower fares for public transport, in place of cars and wider roads. There is also a commitment to protect the countryside, open spaces and playing fields. Jenny Jones calls it a 'green belt' throughout London. Another classic environmental policy is the assurance that all new houses would have to meet energy efficiency standards, and those that aren't can receive financial assistance.
These are all admirable environmental objectives and – in my most lowly opinion – they are steps will need to be taken in our efforts to make a more sustainable society. However, these aren't the concerns of most Britons, or even Londoners. Quite honestly, they care about the money in their back pocket and how they can use it.
Social justice
The other side of the Green message goes beyond environmental issues. The support of a 'living wage' for London and, I imagine, for the wider nation, is a necessary step. The priority given to small shops on high streets rather than outlets from the big brands is another great move that can boost entrepreneurship and re-energise local economies. That is, if it is able to be enforced. Finally, more police on the streets is a message pushed by all parties, so that's not really a point of difference.
In fact, all these 'social justice' issues don't really draw the Greens away from the Labour Party. And, with the more cuddly and spend first approach of Boris' reign in London, I don't think there's much to differentiate them with the Conservative incumbent's policies.
Those are just the messages from the video, but the question is whether this 'vision' can be accepted by Londoners.
My belief is, unfortunately, no.
The problem for the Green Party is that the people that are convinced of their message are in a minority, and the established three parties offer a much more complete electoral package for the majority of voters.
Environmentalism is way down the list of concerns for most voters. The Conservatives, Labour and the Lib Dems do consider green politics but it comes after social and economic policies. For the Greens, environmental concerns are inevitably the primary issue but this won't make them a major political force.
For the Greens to be effective at elections, it appears that they have to be either a protest vote party, or tackle libertarian issues more generally, proclaiming the mantle of 'protector of freedoms' for themselves. However, this might take them away from the environmental focus that attracts Green supporters in the first place.
Yet, I believe this focus on the youth that encompasses the election video could be a winning gambit for years to come. If the Greens can bring that stark reality of environmental danger home for lots of voters, emphasising how the future, their children's future, is not as secure as they'd wish to believe, it could be the key for Green Politics to truly enter Britain's political establishment.


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Heads up Thailand, you've got a big storm of idols coming your way! Mnet is bringing kpop to Bangkok with the Show King M Bangkok concert sponsored by Adamas. The line-up includes huge hits like OneDay (2AM & 2PM), 8Eight, the Brown Eyed Girls, CNBLUE, Kara, Kim Tae Woo, MBLAQ, T-ara, D-NA ("THE BOSS" is one of their alternative names) and many more. With such a star-studded schedule, this event is guaranteed to be a huge success!
As the official poster reveals, the concert will be held at Bangkok's Rajamangala National Stadium next month on April 6, leaving just over a month for fans to freak out and make plans to get to this concert. But that's not all – admission is free!
With at least seventeen artists & idol groups headlining this event (there are seventy-four idols mentioned on the above poster alone), Mnet is definitely bringing out the big guns with this event. Although it may be disappointing for some that no SM Entertainment or YG Entertainment artists have been mentioned, I'm sure this huge line-up will do more than satisfy Thai kpop fans' needs on April 6!
Take out with full credits.
Shared By:Copycatmemory


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Breastfeeding linked to reduced risk of multiple sclerosis
Published : 16 Jul 2017, 18:43
Mothers who breastfeed for at least 15 months over one or more pregnancies may be 53 per cent less likely to develop multiple sclerosis (MS) compared with those who do not breastfeed at all or do so for up to four months, a study has claimed.
MS is a disease in which the immune system eats away at the protective covering of nerves.
The findings showed that women with MS have significantly fewer relapses, or attacks, during pregnancy or while they are breastfeeding exclusively.
"Among the many other benefits to the mother and the baby, breastfeeding may reduce the mother's future risk of developing MS," said Annette Langer-Gould from Kaiser Permanente Southern California.
In addition, women who were age 15 or older at the time of their first menstrual cycle were 44 per cent less likely to develop MS later than women who were 11 years old or younger at the time of their first menstruation.
The total number of years a woman ovulated and other factors, such as number of pregnancies, use of hormonal contraceptives and age at first birth were not associated with risk of MS, the researchers said, in the paper published in the journal Neurology.
"Other health benefits include a reduced risk of breast cancer, ovarian cancer, Type 2 diabetes and heart attack," Langer-Gould said.
For the study, the team involved 397 women with an average age of 37 who were newly diagnosed with MS or its precursor, clinically isolated syndrome, who were compared to 433 other women.
Source: thestatesman
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What's New > Tahoe Medium Hobo - Cognac
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Rich leather and crafted detail make the Tahoe Medium Hobo in Cognac a classic. The jewelry-inspired hardware stands out when paired with the soft leather, perfectly slouched.
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Sabrina Chun, artist of the newly popular Blackprints collection of reverse black and white illustrations of classic cars, found her artistic inspiration from a culmination of different art movements from the mid-twentieth century (1940s and World War II-era propaganda posters) to the late 1950s to '60s British and American pop art, in addition to the retro-futuristic movement of the 1970s.
Sabrina's love of WWII-era artwork has influenced her taste in bold, powerful artwork and a passion for vintage fashion and style. The same portrayal of strength seen in the propaganda posters can also be seen in the design of classic, powerful automobiles which typically incorporate hard lines and robust styling. Without a doubt, she's drawn to striking prints, along with the powerful beauty of classic cars, which are a direct influence of the monochromatic, minimalist and bold style of her new Blackprints collection.
Art, including photography, has always been a powerful influence in Chun's life, which lead to her finding a knack for photographing cars about three years ago when she procured her first DSLR. Chun's first memory of a car was when she was about five years old; her neighbor would drive her around the neighborhood in his two vintage cars, a Ferrari and a Mustang, and she remembers the awesome rides to this day. From that first moment of her hair blowing in the wind, Chun had developed a passion for cars. She soon began visiting the Sonoma Raceway in California with her friends, which she enjoyed throughout her adolescence. She even brought her own NB Miata to the track to test out the car's hyperdrive.
In March of 2013, Chun decided to combine her passion for art design and cars by translating her photographs of classic cars into minimalistic art prints in order to show others what she sees when she looks at a car. Chun has spent years at car shows and track meets photographing her favorite models, and believes that each car's story is displayed through the forged metal that creates the shape of each individual automobile.
Sabrina believes that we are attracted to cars because of their shape and form, their power and performance, and their feel and sound. Each car has its own story and the way a car is designed and built tells everything about its individual personality.
Chun's minimalist art style and Blackprints collection has reimagined the world's most beloved classic cars by highlighting their unique striking features with the intention of reminding the viewers why they fell in love with these cars in the first place. "Each of these prominent and exposed qualities give a car its own definition, which is what viewers recognize and remember," says Chun. "Imagine seeing nothing but that and we can now appreciate these cars in a new light."
Her Blackprints collection includes reverse black and white illustrations of the Porsche 911, '67 Mustang GT500, 427 AC Cobra, Lamborghini Countach, BMW E30, Ford GT40, Volkswagen Microbus, DeLorean DMC-12 from "Back to the Future" and the Ghostbusters Ecto-1. Chun chose these nine cars for her first collection after carefully curating and selecting, in her opinion, the most popular and aesthetically pleasing cars of the past twentieth century; European racing cars and American muscle cars, in addition to two awesome and recognizable film cars, Back to the Future and Ghostbusters.
Each Blackprint is extremely eco-friendly; the photographic-quality prints are made of recycled paper and the ink and solvent are both soybean-based. In order for Chun to bring the elegant black and white silhouette prints to life, she needed help funding the collection, so she looked to Kickstarter, the most popular crowdfunding platform out there today. Within 24 hours of launching the campaign, she raised the funds she needed to bring the collection to print, and has now raised $65,000 more than her initial goal.
Sabrina Chun
To learn more about Chun's collection, visit the project's Kickstarter campaign page.
Images courtesy of Sabrina Chun


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The product will soon be reviewed by our informers. NameEmailPhone NumberPostcodeEnquiry Type Sales Technical Support Product Information Enquiry Details SubmitSubmit closeContact For all enquiries please complete the form below. Olivetti UK Agency Address: 4 Regent Park Booth Drive Park Farm South Wellingborough NN8 6GR NameEmail AddressPhone NumberEnquiry / CommentHow did you hear about us? Olivetti D-copia 1800mf I do get a driver for this printer but it still show on the screen error encountered C6000 contact service provider Expert: Syseng replied7 years ago.
All right reserved. | Privacy Policy | Sitemap | By Monstermedia Login|Contact Us Printers Printer Repair Questions? Finally my PC got up to speed!" Melany Kim 7/18/2016Our main support OS are: Windows 7, Windows 7 64 bit, Windows 7 32 bit, Windows 10, Windows 10 64 bit, Windows XPlease fill captchaIn order to prevent "robots" from misusing our bandwidth,we request that you prove you are human.captchaSend Czech English aboutus products services technicalsupport partners news navigation contact technical you could try here Technicians are Online Now Type Your Printers Question Here...
Ok so when you installed the driver was the printer plugged in? Olivetti D-copia 18mf Specs Overview Olivetti d-Copia 18MF KX is developed by Olivetti S.p.A. Ive used it wirelessly for 7/13/2017 7/13/2017 itstuff A short time ago I changed to windows 10 I have a Epson 7/13/2017 7/13/2017 itstuff Epson Perfection V500 model J251A Photo scanner: You can also try searching for the latest driver in Google.
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Olivetti D Copia 18mf Driver DownloadOlivetti D Copia 18mf Driver Details:Olivetti D Copia 18mf File Name: olivetti_d_copia_18mf.zipOlivetti D Copia 18mf Driver Version: 740CupOlivetti D Copia 18mf ZIP Size: 141.kbManufacturer: Olivetti Olivetti Olivetti Printer Drivers If your driver isn't working, use the driver having the same OEM with the your laptop/desktop brand name. Olivetti d-Copia 18MF KX Overview Comments (0) Questions & Answers (0) Users (0) Olivetti S.p.A.
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Where we debate the value of the CGI additions to the remastered, original 'Star Trek' series, and Chad shows his utter ignorance of proper Enterprise technical terms. It's a nacelle, Chad. A NACELLE!
Tag: VFX
To CGI Leia, or Not to CGI Leia
It's not really a question. Whether 'tis nobler in the mind to suffer the pixelled slings and motion-captured arrows of outrageous special effects, or take arms against a sea of computer-generated actors… aye, there's the rub(ber eraser icon used to delete wrinkles).


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He stepped on to the ledge. The whole city laid down in front of him, seemed to be welcoming him with open arms. The glitter of city that laid before him masked the harshness that the city offered on a daily basis. Everything looks so small from up here, unlike the problems that reality keeps smacking into his face.
He closed his eyes and breathed in the breeze and the chill it offered. The very air seem to reflect his desolate core. Boys are not supposed to cry or show weakness, his mom has always told him that. But he had tried to be strong, to be a man bear the pain and humiliation. But now he resembles a thin shell that will crack soon.
The biggest mistake of his life was when he stepped through the gate of his college and met Rajiv, the heart-throb and senior of the college. That was the beginning of the end. Amir thought about the day when he interrupted what looked like a ragging session. He knew he was doing the right thing. He still believes that. That's how he was brought up. But that didn't sit well with Rajiv. The humiliation of the days that followed still crawls under his skin. From being a person he was brought to nothing and it was termed with a trivial term called prank.
If life has to be this cruel because of fellow human beings only, then what is the point of leading such a life? If a person is not respected in the society then what is his existence in it? He put one feet over the ledge and the face of his sweeth mother flashed in his head. The one person who has always loved him and supported him through everything. The single mother who crimped and saved up to give him the best of everything that this world has got to offer. No. He can't do this to her, not after everything that she has done for him. He is the only one left in this world for her. If she is his strength, then he has to be there for her.
The precipice will not provide answers to his problem. He finally gets off the ledge and sits down and let's go of his emotions. Amir finally realized how close he came to giving up on the dream that he and his mom had always visualized. He wipes of the tears and makes a firm resolution of Never giving up. He was not brought in this world as a coward, and he is not planning to leave this world as one. He turns back one last time to look at the beautiful city spread out before him. Mumbai is a city of dream and he is going to leave a mark behind one day.


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Yesterday I had a rest day so when my alarm went off this morning, I got out of bed and dressed for my run. I didn't feel well, I actually felt like I had to throw up a bit, but I wanted to run anyway. I had to run. Running makes me feel better, so I really needed it. I ended up going 6.36 miles around the river and then headed home. My pace was pretty good considering how bad I was feeling.
One thing that made the run bearable was the weather. It was 65 degrees out with a cool breeze! Were we really in August? It sure didn't feel like it. August is the hottest time of the year in Florida. I guess I got lucky that my contract took me up north for the month. I feel bad for all of my friends and family sweating it out down south. I am really going to miss running in Boston after I leave.


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Xiuhtezcatl Martinez : Protecting the Environment and Indigenous Rights (Paperback) (Linda Barghoorn)
about this item
Number of Pages: 32
Genre: Juvenile Nonfiction
Series Title: Remarkable Lives Revealed
Format: Paperback
Publisher: Crabtree Pub Co
Age Range: 4-8 years
Author: Linda Barghoorn
Language: English
Street Date: February 1, 2017
Item Number (DPCI): 248-38-6567
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Happy Friday at last and Happy Payday weekend for most of you, whether you're out tonight or saving yourself for tomorrow, have a good one! I'm having a quiet one this evening in preparation for the Swimathon tomorrow so MasterChef is probably about as exciting as it gets and I even declined a chocolate eclair at work today *sob*! Don't worry, I'll be making up for it at my local tomorrow night, I'm sure.
After what seemed a never-ending week and my last two practise swims, I'm strangely starting to feel a little bit nervous- the butterflies-in-your-stomach kind of nervous. I started my training for the Swimathon back in September and I'm aiming to complete the 200 lengths within 2 hours but obviously it's not a race and at the end of the day, completing the challenge itself is an achievement.
The amount of sponsors and support I've had has been absolutely amazing and I'm looking forward to spending time with friends and family tomorrow evening. Thank you to everyone who has donated so far (current donations amount to nearly £200 online and offline!) and I know I keep repeating myself (sorrysorrysorry!) but if you wish to sponsor me to raise money for Marie Curie Cancer UK, please click the link below:
The deadline for fundraising is the 30th June 2013 so there's a plenty of time to get involved.
The work that the nurses do at Marie Curie Cancer Care UK is incredible and with our support, it will help them to provide free hands-on care and emotional support to those with terminal illnesses and their families in their own homes, right until the end.
In order for the service to remain free, donations to the charity are essential; £20 can cover one hour of nursing within a patient's home while £3,000 covers the cost of Marie Curie's nursing service nationally for one hour.
For more information about the work that the Marie Curie Nurses do and of course to see how your donations help to make a difference, please visit the website here.
I'm off to get a good night's sleep, with a mental playlist in my head in readiness for tomorrow (I'm thinking a bit of Daft Punk with some Two Door Cinema Club and Rudimental, I'll despair if I get Pitbull stuck in my head on a loop!) and I'll keep you updated via Twitter. Follow me at @daniellestacey1 with the hashtags #swimathon #takeonachallenge and of course, my favourite #justkeepswimming.
Wish me luck!


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Hot Tips (HVAC)
Variable Refrigerant Flow (VRF) is a leading edge, globally proven HVAC technology that can help solve many HVAC challenges faced by educational facilities:
This article originally appeared in the September 2017 issue of College Planning & Management.
About the Author
Kevin Miskewicz is the director of Commercial Marketing with Mitsubishi Electric Cooling & Heating. He can be reached at email@example.com or 888/979-9686.
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Suggestions for Lent
Over at the National Catholic Register, Tom Hoopes has a great article with Lenten suggestions for us procrastinators. Do pop over and read the whole thing:
Ideas for Adults
• Fast with one full meal, no snacks one day a week.
• Skip meat an extra day (or two) a week .
• Give up alcoholic beverages. (Except in social situations; then you get just one!)
• Give up coffee (or reduce to one cup a day).
• Give up all desserts.
• Give up all unnecessary shopping.
• Fast from music in the car.
• Fast from talk radio.
• Begin (or begin again) the daily Rosary.
• Meditate for 10 minutes a day (get a Magnificat to follow those).
• Choose one extra devotion per week during Lent: Stations of the Cross, Eucharistic adoration or a weekday Mass.
• Read a book on the Life of Christ. For example:
Alban Goodier's The Life of Our Lord Jesus Christ
Fulton Sheen's The Life of Christ
Frank Sheed's To Know Christ Jesus
Romano Guardini's The Lord
• Read the Catechism of the Catholic Church's 74-page section on prayer. (Section four; less than two pages a day!)
• Visit a nursing home with your children.
• Forgive someone and patch things up in a visit, or, if necessary, by phone or letter.
• Give up gossip, judging or profanity.
• Find one "act of forgiveness" to make every day: A driver who cuts you off, a co-worker who annoys you, a shopper who cuts in line, a store clerk who is rude or a family member who ignores your needs.
• Say a kind word to everyone you meet.
• Pay a significant compliment (or more!) to each of your children every day.
• Offer to watch the children of a new mother one day a week throughout Lent.
• Visit an elderly friend or relative.
• Save up a significant amount of money for a deserving charity or apostolate.
For Children and Teens
If none of the adult ideas work for you, try:
• Do chores without complaining
• Draw pictures of Holy Week events.
• Restrict your TV, Internet or music time.
• Restrict your phone time.
• Send a letter or picture to a grandmother, aunt or Godparent.
• Make a new friend outside your "crowd."
• Be a friend to a shy person.
• Give up that bad place, person or thing.
• Choose a favorite toy, book or piece of clothing and put it away until Easter.
One Comment on "Suggestions for Lent"
February 19, 2010 at 1:01 pm
I'd like to add one of my personal favorites to the 'books about Jesus' category: "My Beloved Son" by Fr Lawrence Lovasik. It is out of print, but you can find some reasonably-priced used copies at amazon or abebooks. It's not so much about the life of Jesus (how he lived, what he did, etc) as it is about who he is, using explanations peppered with many citations from Scripture.


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The man who crushed the mathematical dream
from Lars Syll
Gödel's incompleteness theorems raise important questions about the foundations of mathematics.
The most important concerns the question of how to select the specific systems of axioms that mathematics are supposed to be founded on. Gödel's theorems irrevocably show that no matter what system is chosen, there will always have to be other axioms to prove previously unproved truths.
This, of course, ought to be of paramount interest for those mainstream economists who still adhere to the dream of constructing a deductive-axiomatic economics with analytic truths that do not require empirical verification. Since Gödel showed that any complex axiomatic system is undecidable and incomplete, any such deductive-axiomatic economics will always consist of some undecidable statements. When not even being able to fulfil the dream of a complete and consistent axiomatic foundation for mathematics, it's totally incomprehensible that some people still think that could be achieved for economics.
March 24, 2017 at 1:13 pm
Logical completeness is not a necessary condition of a functional system. In fact, Goedel's theorem is a proof that to have a function (that is, to be useful in predicting, modifying or determining something) a system 'must' be incomplete, must have an 'outside' with respect to which it is intended to function. In other words, a function must quantify over something other than itself. Goedel's theorem was a formal proof of incompleteness, but its conclusion was already widely accepted prior to Goedel, informally, as a matter of logical necessity, most notably by Tarski, to overcome semantic circularity (the liar paradox), and by Whitehead-Russell in their effort to solve the Russell's paradox by means of the theory of types. On a more metaphysical note, incompleteness is a condition of 'seeing', of being a witness to something other that oneself, and therefore a condition of one's own existence: that 'x exists' entails that x is in a causal relation with something other than itself, or that 'x exists for y'. Taking this back to economics, it's incompleteness is not a deficiency but rather a necessary condition of its usefulness, so any economist claiming to pursue a model of logical completeness is simply inconsistent, and the model is provably false.
March 24, 2017 at 3:12 pm
"…a function must quantify over something other than itself. " That should be sufficient to debunk the standard stupidity of treating money as a measure of value while charging a unit cost for its use!
March 24, 2017 at 3:15 pm
* a unit cost in terms of itself
March 27, 2017 at 12:31 pm
Not sure what you mean by "Charging a unit cost for its use"… interest? That's a bit more complicated and possibly not something I would see refuted by the above.
On the other hand i do believe the above proves that money can't be both a measure of value and be valuable itself. This is formally obvious: it violates the law of identity about value of money on account of definitional circularity (self inclusion).
March 24, 2017 at 5:13 pm
Extremely important understanding. It means that what economics actually needs is a new philosophy. In fact it also signals that what is required is a new paradigm to be integrated into the present monetary and economic systems. The signature of paradigm changes has always been a swapping/inversion of position of dominance/primacy and also a thorough integration of opposites which re-integrates all of the components of the entire system. As the Copernican helio-centric paradigm change was a swapping/inversion of the position of the earth and the sun and the understanding that the sun was to be considered the primary astrological center it was a thorough integration of opposites and a re-integration of the entire system. As Finance is the current dominant/primary business model and its enforced paradigms for the individual are Only Via Debt/ Loan and For Enterprise, For Production Only, so direct monetary Gifting For Consumption is its opposite. Intelligently integrated and implemented into the digital money system this would end the curious and almost entirely overlooked dominance of Finance in what is supposedly a system that advocates free competitive markets, re-integrating and stabilizing both the micro and macro economy.
March 25, 2017 at 10:46 am
Mathematics is a social construction. A product of culture. It is a system of theorems and axioms. Sometimes useful for such tasks as building, navigation, medicine, war, and of course commerce. It is not a pathway to truth, to significance, or, as Newton and Copernicus believed to God. This is how economists should use mathematics. It is how all scientists use mathematics.
Economists don't need to abandon mathematics but they do need to stop using it to fake a world that operates according to one or another, or some group of mathematics theorems and axioms. No world operates this way. The physical universe forces the re-write of mathematical proofs and theorems. Why would anyone believe that the same would not be the case for the social and cultural worlds of human collective life?
March 27, 2017 at 12:58 am
«no matter what system is chosen, there will always have to be other axioms to prove previously unproved truths»
Oh please this is a decades old huge misunderstanding: Gödel two theorems don't state anything like that, or anything of wider philosophical importance, they are just narrow technicalities, that say more or less that a mathematical system cannot be used as its own own proof theory to prove that all its own true theorems are provable in it (completeness) and that none of its own false theorems are provable in it (consistency). It is a technicality of interest only for the historical purpose of discussing Hilbert's programme, and in particular Hilbert's hope that finitary (in the induction sense, not the size of proof sense) proofs of arithmetic would be possible.
The two subsequent theorems by Gentzen are far more interesting on the topic of the difference between logical provability and logical truth, even if still fairly technical, and they much generalize Gödel two theorems by showing that to prove the completeness and consistency of a mathematical system is possible but only using a system with strictly higher order induction. That has nothing to do with «other axioms to prove previously unproved truths» even if there is a vague similarity.
The Gentzen theorems while quite interesting pose no wider philosophical questions or have any implications like «such deductive-axiomatic economics will always consist of some undecidable statements».
PS A very little noticed detail about Gödel and Gentzen's theorems is that they are about whether consistency and completeness of a mathematical system can be proven, not whether the mathematical system is in fact complete and consistent.
March 27, 2017 at 1:33 pm
Yes, Goedel's proof works only for a formal, narrow system, precisely because it would not work, by its own premise, for all of reality. All formal theorems operate on a very limited basis, but that does not preclude broader philosophical implications that are both relevant and logically consistent.
If truth must be knowable as truth in order to be meaningful, and therefore be truth per se, then provability is a necessary and sufficient condition of truth. If this is correct, then the theorem implies that truth (not just provability) and logical completeness are mutually exclusive.
The proof of course was only a formality confirming something already known, at least since Aristotle's formulation of the law of identity: that identity cannot be a proper part of itself because that would imply difference of itself from itself, therefore non-identity, therefore untrue identity.
Consequence: totality is untrue; truth is essentially incomplete.
Conversely, we can talk about a 'formal' system as an identity, we can maintain its truth only because its formality and systematicity is defined from the outside, in relation to external identities or some meta-language, and is as such logically incomplete.
We never needed Goedel for that, but his rigour is certainly appreciated.
March 28, 2017 at 12:23 am
«Yes, Goedel's proof works only for a formal, narrow system, precisely because it would not work, by its own premise, for all of reality.»
«Consequence: totality is untrue; truth is essentially incomplete.»
That is random gibberish, it has nothing to do with the narrow ambitions of Hilbert's programme, and the meaning and implications of Gdel's two theorems in relation to Hillbert's programme.
Unfortunately those two theorems attract wild meaningless speculation by those that like to string important-sounding words together.
it is usually a good test of the understanding of Gödel two minor theorems whether the much more interesting Gentzen extensions of those two theorems is mentioned.
«truth (not just provability) and logical completeness are mutually exclusive»
That's more gibberish, and there is an interesting detail: the consistency ("truth") and completeness ("provability") of the theory of arithmetic have both been proven decades ago. How has that been possible if they are mutually exclusive?
April 1, 2017 at 3:43 am
Blissex et al: If you haven't read it, you might like Torkel Franzen's Gödel's Theorem: An Incomplete Guide to Its Use and Abuse here is a positive review. Though I don't think he would have agreed with all of Blissex's judgments above.
April 1, 2017 at 8:07 pm
I am not a logician but i studied some –including both goedel and Gentzen (i used to have a kind of informal proof of one of godel's theorems in from 3 to one lines –basically a restatement of liar's paradox) A famous book by Trostky's secreatary collects many famous papers —from frege to godel–and there are later ones on Emil Post, etc.–like Godel somewhat eccentric.
regarding the view that Kowalik writes 'random gibberish', one should read some of Emil Post 's stuff–who is famous for 'post's problem' (a very nice one—i think some have shown that can be solved in 10-15 lines). Some of Post reads like 'random gibberish' or 'poetry' but i personally find it somewhat stimulating and coherent–its saying the same thing but in a different way, and while imprecise may be one way to get nonexperts somewhat of an understaning or the concept. (People do this with relativity theory all the time — this gives some physicists (who i view as being into 'rigor (mortis)'
heart attacks, but some others (eg VI Arnold of KAM (ergodic) theory say actually that's fine , and also that's how he was educated early on to develop an interest in physics.
I don't quite remeber the references or even the exact results, but i've seen quite a few applications of godel's theorem , undecidability and computability results in econ. The math is basically all the same. Very abstract, mostly useuelss except philosophically, but i think maybe economists should spend more time on this rather than pretend they are solving economic problems—eg unemployment. One could have full employment tomorrow if we gave everyone a UBI or an MMT government job and put them to work solving math problems which interest them or their community.
(eg some unemployed person could manage my dwindling bank account–write a budget while still possible. ).
The Lowenheim Skolem theorem i think is as interesting as goedel, gentzen, post etc. (later stuff by Paul Cohen on AoC). At present i think its still an open question whether any of this will ever be applicable (T H hardy thought his number theory was 'useless art' but he was wrong. Philosopher Badiou thinks transfinite arithmatic applies to the economic system of trotskyism). On Va Voir. I think it may be a conveiant notation. ) (see S Feferman).
April 2, 2017 at 5:45 am
Mart, good thoughts. For any of this to work, however, there has to be a community in which the work can be done and for which it is done. Neoliberals (current version fascists) have spent quite a bit of time and money the last 50 years destroying both the notion of community and its day-to-day functioning.
March 29, 2017 at 11:00 pm
"the consistency ("truth") and completeness ("provability") of the theory of arithmetic have both been proven decades ago. How has that been possible if they are mutually exclusive?"
Completeness is Not provability. But I get what you mean. The point is that the theory of arithmetic is not complete: the proof of consistency does not (and cannot) obtain from the theory itself, according to Goedel. Gentzen proof is meta-arithmetic as it is said to require accepatance of transfinite induction (whatever that is). In that sense, it can be taken as a demonstration of Peano arithmetic incompleteness.
One cannot prove that A is an A without some normative framework that is already accepted as true, the proof of which requires a meta-normative framework. This clearly leads to infinite regress unless interrupted by a decision to take some framework as true without a proof: therefore incompleteness.
For example, we cannot formally prove that the law of identity or non-contradiction is true, we simply assume this as a matter of practical necessity based on what kind of beings we already are. Consistency of our meaning relies on these laws, but they are not provable any more than 'correcteness' of our being.


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And you can throw in a gale too, but the one opportunity a year to taste through the latest vintages of Eben Sadie's Ouwingerds range as well as Palladius and Columella is not to be missed. This year's event had even more urgency given every wine had sold out within a couple of days.
Both last Friday and Saturday delivered one of this winter's deluges along with cold and windy conditions, but the route I take to the Sadie's Perdeberg farm, even when it's wet and grey, is a relatively easy and certainly a scenic one with wheatfields lining the road and mountains in the distance. Relatively easy, for the last 4 kilometres is along a dirt track more suited to a 4×4 than a very old Toyota Conquest! But I made it in just on an hour, which is nothing in terms of many wineries strung out across the winelands.
The greeting, as always, was warm from the Sadie siblings – Delana, Nico and Eben – and other friends there; not too many of them at the early hour of my arrival, so I could get stuck into tasting without being diverted into the social chat that happened later.
With the Ouwingerds, it was the 2013s on show. As far as the whites go, I noticed an unusual firmness of structure about them; no question of imbalance, just a vintage character. That said, Skerpioen (chenin, palomino) is also a little fuller with good intensity of understated (if those two aren't incompatible) earthy, honey flavours. The firm acid backbone is notable on Skurfberg (chenin), as is its subtle yet expansive ripe apple character. I believe T'voetpad (semillon, palomino, chenin, muscat d'alexandrie) is Sadie's favourite this vintage. It has a lovely lightness of touch but also impressive mouthfeel, finishing with an intriguing hint of muscat. Apart from Mrs Kirsten, I feel T'voetpad has the most interesting future. Kokerboom (semillon) is also on the fuller side, with semillon's typical beeswax features. These are relieved by a marked mineral tail. It will need time to come around from this and its current rather sullen nature. For concentration and structure, Mrs Kirsten (chenin) can't be beaten; she will need lengthy ageing, but I hope the most appealing fennel and honey notes hang around as she does. There was so little made, none has been sold, so we'll have to hope the Sadie's hold on to her and we're invited when her various bottles are opened.
If I enjoyed the whites, it's the reds this year that have got me really excited: Soldaat (grenache), Pofadder (cinsaut) and Treinspoor (tinta barocca); all in my humble opinion are the best to date. Sadly, I didn't manage to buy any Soldaat, but for those who did, please don't be in too much of a hurry to open it. It glints like a valuable ruby, has deep and enticing wild strawberry and pepper spice fragrance. But there's lot more to evolve and it has the structure to do so. It captures the essence of grenache in its light texture and freshness. I have managed to lay my hands on some Pofadder, which is a stealthy cat compared with Soldaat. A glimpse of wild red fruit spice is here one minute, gone the next, but it'll return and develop. It's very tight with tannins that are both vibrant and currently pretty impenetrable. Of course with sound balance, it's worth however long it takes to settle and mature. I still remember the first Treinspoor, well, actually primarily the tannins, which were fearsome but which Sadie firmly believed will resolve. They're much more balanced in this vintage, allowing for a more elegant expression of tinta with wet gravel soil and violets and a lively freshness. As with the other reds, ageing will be rewarded.
Back a vintage to 2012 with Palladius and Columella. It's amazing how even 3% viognier, the amount in Palladius, makes its presence felt, as does the wine itself. It's more forceful and pithier than usual but it also has underlying breadth. It really does need time to pull together, which I hope everyone who jumped in to buy it will allow for.
If I am a little ambivalent about Palladius right now, Columella is a totally different proposition, and my favourite vintage to date. Sadie says it reminds him of his 2010, but for me this has more precision, detail and personality. I keep saying what a wonderful vintage 2012 is for red wines – and crossing my fingers that I'm not the only one to have experienced these wines! – as with Columella, the best are totally in harmony if not yet unison, as structure is a big part of their success. Lengthy cellaring will be advisable for some.
Every year I come away full of admiration for the subtle yet characterful wines the old vineyards deliver thanks to Sadie's ever-greater understanding of them. I fear these heirlooms are sold too cheaply; they are surely among the most authentic of South African wines.
I think I've written before how much I enjoy the way these new vintages are presented; all those involved are there to answer questions, otherwise it's a happily casual occasion. Certainly worth the journey, whatever the weather.


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Week #37: Remember me.
Your assignment is to write your own obituary ("death announcement" in
case obituary doesn't translate well to our non-English Journaleers.)
Don't think of it as morbid, but as a reminder of who you want the
world to see when they look at you. Obituaries are about lives
well-lived, and not the death that cut them short.
So write about yourself as you would want to be remembered, or how you
think you will be remembered. What was important to you? What were your
greatest accomplishments? What aspects of your personality or passions
will people think of when they think of you? If you like, make a
prediction on how you die, and how old you'll be when you die?
Requested by my partner not to complete this home work, i respect his wishes. So yeah this week will not be completed. Off to a good start eh? 🙂


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Gay Marriage And Marijuana
People think that I'm a liberal, but this is one issue that may show otherwise. My state had a constitutional amendment to ban gay marriage a few years ago and North Carolina will vote on their amendment tomorrow. I've hesitated to weigh in on the issue in my blog because I didn't want to offend any gay readers that I might have. I still don't, but maybe it's time to put my two cents out there.
I voted for the ban, but I should explain why. While I find sex between two women kind of a turn-on, sex between two men totally disgusts me. I don't care what people do in the privacy of their homes but I don't want it flaunted in my presence. It's only been a few years since gay people were denigrated as queers and fags and were beaten and robbed for the fun of it or dragged to their death by bigoted assholes. Then, all of a sudden as if a switch were flipped, all the gays came out of the closet and states began allowing them to marry. Now, six states plus the District of Columbia have legalized it.
My problem with it is two-fold. First of all, it's a matter of semantics. Marriage has always been about a man and a woman, a husband and a wife, a bride and a groom. If a same-sex couple marries, which one is the husband? Which one is the bride? Who decides? It makes things uncomfortable for us heterosexuals who don't know what words to use.
Secondly, I can't believe that this issue has come to the forefront and gained acceptance so quickly while smoking marijuana is still illegal and largely unacceptable. Where is the equity here? Is it fair to legitimize one group's behavior and not others'? I don't want to sound like a Bible-thumper, but the Bible does explicitly poo-poo homosexuality but doesn't say anything against catching a buzz.
I think that, instead of going immediately from the closet to the altar, there should be an in-between step that would be satisfactory to most Americans. Gay people should be allowed to engage in a "same-sex civil union" that affords them all the rights and privileges of marriage without calling it that. Leave "marriage" for a man and a woman, and come up with descriptives for the participants in this new form of legalized coupling. We already have terms like "partner" and "significant other", but maybe some new words could be coined that would work even better. I don't have a problem with civil unions for gay people who want to partner for life, but I do have a problem with calling it "marriage". So let's do that and get on with the business of ending the failed war on drugs.
Chuck permalinkMay 9, 2012 6:41 PM
OK . . . so you're uncomfortable with some of the issues surrounding gay marriage. That's YOUR problem. Why even concern yourself with it? Gay rights have nothing to do with you, and you can't possibly be harmed by giving gay folks the right to marry. And if you don't want to sound like a Bible-thumper, don't bring up what the Bible has or doesn't have to say about anything. While I'm straight, I'm not narrow. And I'm so sorry that the few gay people I know and care for are so discriminated against. Remember that it wasn't too long ago that inter-racial marriage was disgusting, and now it's commonplace. Hopefully, gay marriage will be as accepted in the not too distant future. And what does legalizing weed have to do with gay rights?
May 17, 2012 1:46 PM
Good question.


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Date: 02/25/2016
Time: 6:00 pm
Location: Halyards (406 3rd Ave., Brooklyn)
Price: Free
It's our birthday and we're throwing a party. Please stop by to help us celebrate 5 great years in Gowanus. We will have live music, free pints to hand out, and lots of festivity. Come join old friends and new at Halyards' Fifth Anniversary Party!
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The Bar: Chuan Shabu
The Address 301 Park Avenue
The Day and the Time Thursday at 7pm
The price Nine bucks (one of the pricier ones)
Did they ask me if I wanted a lime She put it in
What was the type of gin She gave me some choices and I think I picked a high end Tanqueray. I smiled and nodded and just agreed to what she said, like every good improv actor is trained to do.
What was the gin and tonic like It was a good solid drink, strong, but good.
The Joint This is an interesting place. It is a restaurant that focuses on hot pot cuisine where people put raw food into hot broth and then eat the results. Its a very participatory way to eat and this evening had four or so tables of people having a good time. This was not sedate eating and it seemed that the people at the table were having a good time.
The joint is clean and ultra modern in a mid twentieth century kind of way. The bar was handsome with lighted shelved for the drinks. The lights slowly changed colors. It was neat for my limited stay there but I could imagine that it could drive a fella to madness after a while. "The bar was green and then it was blue and then it was red. It was just what the squirrels told me would happen! The squirrels always know!"
General Impressions The bar had three other people there. One off duty fireman looking mopey. The bartender knew him and tried to joke with him about his job and other things and he just icey stared her. Another couple were drinking and eating and talking and talking. It seemed like a light night. This bar had a cool sophistication as does the rest of the place. I don't know if it will find its audience, I hope it does because its different Its a clean, fun bar, but as it was, with more bar space than patron, it also felt sad and lonely.
Amount of Time in the Joint 10 minutes
Will I come back Maybe for trying the shabu hot pot, that seems fine, and the place does strike me as a nice looking place, nicer than most, but as a bar, not for me. Like I said, I hope people who want this bar finds it.