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Discover the splendor of Vermont from our country inn located on a 440-acre historic farm in the beautiful and undiscovered Northeast Kingdom, just 3 hours from Boston and 2 hours from Montreal, Canada.
"One of the most breathtaking hilltop views in Vermont" - Vermont Life
The Inn at Mountain View Farm is open as a bed and breakfast from May 15th through the end of October. During the rest of the year, our townhouses are available for rent by the weekend or the week. The brick creamery with nine rooms is available for larger groups. We are accepting wedding and lodging reservations at anytime. To inquire, please e-mail or call (802) 626-9924 for assistance.
Relax on our 440 acre farm estate, laced with miles of hiking, biking, and cross-country ski and snowshoe trails, known as the nationally acclaimed Kingdom Trails. Great alpine skiing and snowboarding are found at Burke Mountain Ski Resort, just 10 minutes away.
"Best of New England... Most Historic..." - New England Magazine
Settle back in one of our 14 casually elegant guest rooms or luxury suites. Plan a romantic Vermont honeymoon, getaway, a memorable Vermont wedding or family reunion. Our Farmhouse Vacation Rental is ideal for family vacations. Check out the vacation packages for outstanding value. Pet-friendly accommodations are available.
Nearby attractions include Fairbanks Museum & Planetarium, Cabot Creamery, Stephen Huneck's Art Gallery & Dog Chapel, antique shops, St. Johnsbury Golf Course, swimming, canoeing and kayaking on pristine lakes and more. For a taste of France, Canada is just 45 minutes away.
Home :: Activities :: Kingdom Trails :: Food :: Rooms & Rates :: Weddings :: Special Packages ::
Functions & Private Parties :: Yoga Retreats
Contact/Directions :: Animal Sanctuary :: History :: About :: Press Reviews
© Inn at Mountain View Farm | Darling Hill Road | East Burke, Vermont
802-626-9924 | 800-572-4509 | email@example.com
Website Design by Tirna Designs, LLC


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We're proud to have an in-house lender to provide our clients with the most efficient and clear housing transaction. Preferred Home Lending is our mortgage team with over 65 years of combined experience.
Our agents have direct access to Preferred Home Lending loan officers in their offices— talk about convenience when it comes to your real estate contract! PHL provides competitive rates and the insight into the current market to make sure you have the right loan for you.
Already Pre-Approved? It Pays To Compare!
The program is very simple. We want to make sure that you have the very best mortgage to meet your financial needs. With this program, you can find out in three easy steps.
- Present a copy of your Loan Estimate or pre-approval letter from a non-affiliated lender.
- Obtain a pre-approval letter from Preferred Home Lending, allowing you to compare offers
- Receive a $100 Visa Gift Card.
No strings attached. It's a win-win for all buyers. You will either walk away with a better mortgage with PHL and a $100 gift card or you will walk away knowing you have already secured the best mortgage for your needs and have just gained a $100 gift card for getting a second opinion.
This promotion is valid 10/1/17 - 3/31/18. Please present your current (within 10 business days) Loan Estimate or pre-approval letter at the time of your request for your pre-approval. If you have a current lock-in agreement, this is not an inducement to transfer your loan. You are not required to choose Preferred Home Lending for your lending needs to qualify for the gift card. A pre-approval is based on our preliminary review of credit information only and is not a commitment to lend. When applicable, we will be able to offer a loan commitment upon verification of all application information, satisfying all underwriting requirements and conditions, and providing an acceptable property, appraisal, and title report. Pre-approvals are subject to change or cancellation if a requested loan no longer meets applicable regulatory requirements, there are changes in your credit report and/or credit score or your current financial status or application information changes or cannot be verified. Pre-approvals are not available on all products. Contact this mortgage loan officer for details.
Having a solid professional team throughout your homebuying experience makes the transaction smooth and keeps the timeline rolling. When you begin working with your Select Properties agent, the first step is choosing a lender and getting approved— that's where we come in!
Here are the basic steps to take when starting your mortgage process:
- Meet with one of our Preferred Home Lending loan officers to become pre-approved.
- Once you have an accepted offer on your dream home, have done inspections and negotiations, now is when you will work the closest with your PHL team to finalize your loan approval.
- At closing day, your PHL loan officer will be by your side as you get the keys to your new home!
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subset: commoncrawl


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Illegal units are living spaces, usually apartments including separate kitchens and bathrooms, that were installed without a permit and may not meet the City's zoning requirements and safety standards.
This section does not cover:
If you are a tenant in a unit that has been identified as an illegal unit, you do not have to move until you receive a written notice to do so. In many cases the owner will be able to legalize the unit.
Tenants who are required to move out of an illegal unit must be given proper written notice. They may also be entitled to relocation assistance paid by the property owner. Please see the Seattle Municipal Code (SMC) section about just cause eviction, SMC 22.206.160(C).
Director's Rule 7-83, Determining the Existence of a Dwelling Unit for the Purpose of Code Enforcement
If you receive notice of a code violation and don't fix the problem in a timely manner, we may fine you $150 to $500 a day. Additional fines are charged for violations in single-family zones. We will also charge you for inspections.
Ask Us


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This Sunday's New York Times Book Review featured a review of its current #2 best-selling children's book: The Curious Garden, a lushly illustrated tale of a boy who finds an expanse of flowers and plants growing in the most unlikely of places: an abandoned elevated rail line.
In last week's Book Review podcast, author and illustrator Peter Brown talks about his inspiration for the story: the High Line, "this lush, wild garden area that was taking care of itself. It was really this pretty miraculous site. And so when I discovered that place, when I first moved to New York, I decided that I wanted to make a book about nature living in the city in sort of an unlikely way."
You can listen to the interview here. If you missed the readings at 192 Books and Books of Wonder, check out Peter Brown's web site for information on upcoming readings.


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Players come and go in the transfer market. Some stay for a few years, while others leave after one season. But for a select few, they want to spend their whole footballing careers at one club.
Here are five of the most loyal players who currently still play.
5. John Terry | Chelsea
Since establishing himself in the Chelsea first team in 2000/01 season, John Terry has become one of England's finest centre-backs. He turned into a fine defender for both club and country and has thrown his body into all kinds of tackles.
He joined the Blues at a young age and has got though some tough times in his Chelsea career. Although he may not be the star Chelsea and England have been looking at recently, that hasn't forced the defender away from Stamford Bridge.
He has had an impact in English football and in the Premier League, from scoring goals to making the most vital of challenges.
4. Carles Puyol | Barcelona
Without a doubt, Carles Puyol is one of the world's greatest defenders. After climbing the Barcelona ranks and into the first team in 1999, Puyol has progressed over the years to make him a valuable player to Barca. He has now made over 500 appearances for the club, and this number doesn't look like it's going to stop. He may not be a goal threat, but he certainly has plenty of knowledge and skill in the back-line.
3. Paul Scholes | Manchester United
Paul Scholes certainly has a powerful foot on him. The Ginger Prince has been smashing in the goals for Manchester United since the early 90s, and has made 700 appearances for United.
The player took a break from life at Old Trafford in 2011 before making a massive return to the squad a year later. He didn't leave for another club, or for a pay rise, he simply left because of retirement. He made a comeback for the same team, after the club realised that no player of Scholes' calibre is too old to make an impact in games.
2. Steven Gerrard | Liverpool
This English talisman hasn't attracted much attention from other clubs. Not because he isn't great, but due to the fact that he has devoted his loyalty and heart to Liverpool.
He may have played a considerable less amount of games for his club compared to Scholes, but he has frequently shown his devotion to Liverpool.
Clubs know that the player has no intentions to leave the club, and don't stand a chance to persuade Liverpool to cash in on the player. He's currently one of England's best, and will certainly be a well-remembered name even into his retiring years. Gerrard is simply one of those players who probably play their whole career for one club.
1. Ryan Giggs | Manchester United
Giggs is one of the superlative players Wales have produced. He has provided many wonderful strikes for both club and country. Despite being at the age of 39, he is still as lethal as ever.
Manchester United have managed to get very far with this player. He keeps the squad strong and shows that he has unfinished business at Old Trafford. His success at United hasn't dipped. The fans and the manger still have faith in him, and he looks set to win a couple more trophies before retirement.
He's simply one of United's wisest and recognisable players currently in the squad.
DISCLAIMER: This article has been written by a member of the GiveMeFootball Writing Academy and does not represent the views of GiveMeFootball.com or SportsNewMedia.The views and opinions expressed are solely that of the author credited at the top of this article. GiveMeFootball.com and SportsNewMedia do not take any responsibility for the content of its contributors.
Do YOU want to write for GiveMeSport? Get started today by signing-up and submitting an article HERE: https://www.givemesport.com/writeforgms


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News Release
Acclaimed pianist Scott Kirby
bring ragtime, jazz, Creole, blues and more to
Highly praised pianist/composer Scott
Kirby will perform classic jazz, ragtime, terra verde,
the blues and Creole music in a Manchester College concert on Sunday, March 20.
"In Scott
Kirby's playing, we encounter the very essence of
ragtime. He is the embodiment of the Scott Joplin
ideal," wrote Edward A. Berlin, author of The King of
Ragtime: Scott Joplin and His Era. Kirby's
performance of his distinctly American arrangements have
brought audiences to their feet cheering and critical
acclaim ranging from "brilliantly performed" to
"charismatic" to "a ragtime composer with few equals."
The Manchester College performance begins at 3 p.m. on
March 20, in Cordier Auditorium on the north side of
campus. Tickets are $7 for adults and $5 for senior
citizens and non-MC students. For reservations (which
are not required), call 260-982-5551.
promises to provide his northeast
Indiana audience with a unique performance of
examples from North America, South America and the
Caribbean, with composers ranging from jazz pioneer
"Jelly Roll" Morton and Joplin to Ernesto Lecuona of
His 21 CDs
include the four-volume The Complete Scott Joplin,
More Damn Good Ragtime, Grace & Beauty, Ravenna and collaborative projects that
include Terra Verde, Ragtime Primer and
57 Kinds of Blues.
Terra verde
(green earth) is an emerging genre with roots in
European romanticism and in a wide variety of
Pan-American styles, Kirby explains. This contemporary
cousin of classic ragtime contains hints of Chopin,
Gottschalk, Joplin, early jazz and a mélange of
Latin-American popular and folk music. For more about
terra verde, visit
the web site of Idaho-based Viridiana Productions Inc.,
which distributes Kirby's works.
A native of Ohio, Scott Kirby studied piano privately with Robert
Howat of Wittenberg University and Sylvia Zaremba of The Ohio
State University. He has performed in ragtime jazz
festivals in the
United States,
Norway, Hungary, France and Belgium
and was musical director of the Scott Joplin
International Ragtime Festival and the Rocky Mountain
Ragtime Festival.
Kirby also is
musical director of the Scott Joplin Ragtime Festival in
Sedalia, Mo.,
and the Rocky Mountain Ragtime and American Music
Festival in Boulder, Colo. For more about Scott Kirby,
visit his official website:
The concert
is part of the public program series of Manchester
College. For more about the college, visit
Manchester Media Relations


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Beaumont/Port Arthur
James Evans, Big Bend photographer, comes to the McFaddin-Ward House sharing his wit, humor, and life's work capturing images of the formidable national park in South Texas on Thursday, July 21, from 6:30-8 p.m. Evans fell in love with Big Bend on a hiking trip 28 years ago, so he set up camp … permanently. He's been taking stunning pictures ever since, has authored two books, and finally got married this year.
The McFaddin-Ward House is continuing the grand tradition of decking the halls of the museum this year, and with three events – on top of regular tours – there are plenty of chances for you and your family to see the historical house this holiday season.
The McFaddin-Ward House is hosting an evening of holiday cheer Dec. 20 — "Eggnog Thursday." Join the fun and get into the holiday spirit with this chance to see the historic home with halls bedecked with festive decorations in celebration of Christmas. Tasty treats and delicious eggnog will be served in the visitor's center of the museum, and attendees can take advantage of a self-guided tour. The community is invited to attend from 5 to 7 p.m. The event is free and open to the public.
Four area museums are participating in Smithsonian Magazine's program Museum Day Live! The W.H Stark House and the Stark Museum of Art in Orange, the Museum of the Gulf Coast in Port Arthur, and the McFaddin-Ward House in Beaumont are offering free admission for two on Saturday, Sept. 29, to anyone with a complimentary ticket from Smithsonian Magazine's website.
While we harbor no disrespect for the Wall Street Journal who called us "that scrappy little paper from Southeast Texas," we prefer to think of ourselves as simple seekers of the truth. We're of the opinion that headlines and sound bites never tell the whole story. Our readers demand all the facts, facets and flavors of every story or event. And, they expect to be informed, educated and stirred to action.
For this week's New York Times crossword puzzle, pick up a copy of this week's The Examiner on newsstands now.


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The following are arrests and citations recently issued in Craven County:
The following are arrests and citations recently issued in Craven County:
New Bern Police Department:
Nicholas Austin Norman, 20, 195 Macedonia Church Road, Vanceboro, Nov. 21, misdemeanor larceny, attempt to obtain property by false pretense. Officer: W. Hollowell.
Lukas Hack, 19, 105 Connor Grant Road, New Bern, Nov. 20, breaking and entering a motor vehicle (2 counts), misdemeanor larceny (2 counts), possession of stolen goods or property (14 counts), financial card theft (12 counts). Officer: B. Lewis.
Loyd Arnold Knowles, 70, 3407 Oaks Road, New Bern, Nov. 20, felony possession of cocaine, possession of drug paraphernalia. Officer: G. Salen.
Craven CountySheriff�s Office:
Mitchell Rendall Pearsall, 40, 672 Waller Road, Mt. Olive, Nov. 21, possession drug paraphernalia, possession or distribution of meth precursor. Deputy: G. Quick.
Sandy Lea Bland, 36, 2885 Terrapin Track Road, Washington, N.C., Nov. 20, misdemeanor larceny. Deputy: A. Callaway.
Kevin Ray Hales, 37, 2698 N.C. 581 North, Pikeville, Nov. 21, possession of drug paraphernalia, possession or distribution of meth precursor, possession with intent to manufacture, sell or deliver methamphetamine, trafficking opium heroin (2 counts). Deputy: G. Quick.
N.C. Highway Patrol:
Demetrius Smith, 19, 1023 Karen Dr., New Bern, Nov. 21, speeding, driving while license revoked. Trooper: J.A. Magana.
Oscar Joseph Ward Jr., 59, 762 Goshen Road, Pollocksville, Nov. 20, driving while license revoked. Trooper: B.M. Riggs.
John Lee Brown Jr., 58, 117 Hagar Ave., Pollocksville, Nov. 20, aiding and abetting driving while license revoked. Trooper: B.M. Riggs.
Nicole Denise Whitfield, 39, 108 Chastain Court, Jacksonville, Nov. 20, driving while license revoked, speeding. Trooper: S.F. Brown.
Mark Wesley Groshans, 54, 1302 Pelican Dr., New Bern, Nov. 20, driving while impaired. Trooper: M. Riggs.


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Hiding behind tabling a vote
To the Editor:
As an original member of the LTFPC, I need to address Ms. Bachus' comments in the Dec. 12 Beacon article that she was told by members of the City Council that the committee's recommendation to re-purpose Warwick Vets "… had actually been written in January and the committee had just been flushing out the plan to make sure it would work."
That is patently false. The idea, among others, was floated in January, but the committee opted to look at junior high consolidation instead because, at that time, the committee as a whole felt that was a better way to go. Look at the meeting minutes. I don't know what was said and to whom, but I'm reminded of the children's game where one child is told that the "dog is brown" and by the time the story is passed down to the end of the line, the dog has become a cow and its color red.
The LTFPC did not begin to discuss in any appreciable way its final recommendation until the summer months and not sooner. Period. I'm glad that Ms. Bachus admitted that this was not part of her decision to propose a consultant because it was just not true. Further, the School Committee should not have re-arranged the agenda to allow Ms. Bachus' proposal to go before the vote on the LTFPC's plan. Rather, they should have voted on the plan first and gone on record as either supporting or not supporting it and then entertained Ms. Bachus' proposal. Instead, in my view, they hid behind Ms. Bachus' proposal, which rendered a decision on the recommendation a moot point. While some may see this as a distinction without a difference, I vehemently disagree. Leadership sometimes requires making difficult decisions, but make them you must. A vote of "No" was fine, but at least take a vote!
Though I'm not convinced of the necessity of a consultant, I accept the decision and I await their proposal(s). Should their recommendation(s) include consolidating/closing/re-purposing school buildings, then I'll also await the requisite criticisms that'll accompany them that will include, but not be limited to: The choice of an out-of-state consultant; the choice of an in-state consultant; their mysterious link to the mayor, the council, or the superintendent; the overly broad scope of the bid; the overly narrow scope of the bid; their lack of understanding of how we do things in Warwick; their lack of understanding of our various communities; the source and veracity of their data; the "secret" data that was never provided; the people should vote on their recommendations; and finally, the cry that it'll be too close to an election and we should hold the decision for the new School Committee to address in January 2015.
David Testa
LTFPC member


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I have a Capital One Secured card, and my limit is $201, if I increase my limit to $500+ will that boost my score? I have a 720 score, and I just got the card last month.
It depends. It depends on whether or not your individual and overall util improves as a result of this CLI and depends on the amount of that change, if any at all. For example, if your reported balance is $0, and the CL is at $201, then your utilization is at 0%. Increasing the limit to $500 would still mean a utilization of 0% and your score won't change. However, if your reported balance was $201, for example, then your utilization is at 100%. If you aren't paying off your balance, then increasing the limit to $500 would drop the utilization to 40% vs. 100%. You could very well see an increase, but that depends on the change to your overall util which factors in other CCs, certain HELOCs and LOCs, and includes some CC COs.
Welcome to the forums!
Are you just starting out with credit?
Do you have any other credit currently?
Where did you get that 720 score?
This is my only credit card (secured) , and I got the score from Experian.com I have no other credit accounts.
The sooner you get 3 credit cards the better. It has become generally accepted on these forums that 3 credit cards are needed to maximize your scores. That score from Experian.com is a FAKO not a FICO. It has no bearing on what your actual score, pulled by a lender would be. My FICO (This website) is the only place to purchase an accurate score. You can only purchase an Equifax or TransUnion score here. Experian scores are not available for consumers to purchase anywhere.
Your problem, and the problem you will have for the next few years, is that you have what we call a "thin file". That is little to no credit history. The sooner you get more credit the better.
My suggestion to you is as follows:
Apply for a Walmart credir card today. As long as you don't have any negative information on your report you should be approved. When you sign up for electronic billing you will get a TU08 FICO score for free. Don't worry if they start you out with a small credit line, they are very generous with credit line increases.
Having 2 cards reporting will be much better for building your scores and history.
Once you have these cards reporting for 6 months you will be ready to get another card.
I was approved for a Walmart card (soft EQ hit, Fico score 638) with some negatives, 5 30 day auto lates in last two years, 1 collection 2007, approx 82% util, with two cards 90+, AAofA on other accounts was 4+ years though. Just an FYI.
Yes. what increases your score is the "utilization" ratio. this means your (card balance / credit limit).
card balance 25 125
------------------ ---- = 12.5% ----- = 31.0%
credit limit 200 500
Rule of thumb is keep the utilization below 9% of your card balance and pay it in full every month. That means $500 * 9% = $45/month. If you use the card the "traditional" way that means charge $45, put the card in the freezer so you won't use it, then pay the card balance when the bill comes. Then re-use the next month. However, the volume, from the bank perspective, assuming I am correct, shows a volume usage of $45 * 12 = $540/year. FYI, your credit may only go up 1-3 points every month but if it is going up, regardless of the amount, you are making the right decisions.
For myself, if I understand correctly, their "hidden" algorithm, this is under the "character" category of the 3 C's of credit. means show them you can handle the volume of the credit line you desire. If that means making multiple payments to accomplish the credit limit you want, then so be it. When I started, I paid every week. this means my volume was $200 x 4 = $800 a month volume and paid in full every month, just in 4 equal payments. When you first open your card, this technique will not work because they hold payment for a two (2) week period until they get confirmation the payment has cleared. After a 6 month period, they finally quit arguing with me accepted that i never bounce and my credit limit hold is posted back to the account the next day. What I did was to charge to the credit limit every week, pay it 3 days later after the charge went from pending to posted plus i increased my line an average of $300/month to the savings account and increased my usage and paid it off every week.
Review period for "unsecured" credit -- i wouldn't advise calling them just demonstrate that can handle the credit line you want.
The second category is called "capital." In the present day where people are laid off, etc., banks are nervous. That means show them you can "save".... save at least $100 to increase your line of credit AND I recommend save $100 to a seperate savings account for rainy day expenditures. this way you never get caught with a large payment or missing a payment which is even worse.
Basically, my strategy is to rally people to save $100/month in the CD account. When they give or authorize you an "unsecured card", then roll that over to a $5,000 CD with capital one and continue the $100/month savings. If my research and theory are correct, keep that behavior up -- pay in full every month, 9% utilization, and savings $200 a month between the CD and rainy day fund, and they will increase your credit line. ($100x12 months) x 5 years (using capital one's definition of average credit level) is $6,000 in the bank. with these assets, $5,000 in CD and $1,000 for backup payments, you will transition to the nice "unsecured" cards rather quickly plus of course cleaning up any "other" bad credit you may have.
I am at the $3,000 credit level, 10 months into the card, and have acquired $450 total unsecured credit. i will post the results when i get my annual review to see if I am right about what capital one decides to do plus the letter i sent them.


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Cell ablation is a powerful tool for studying cell lineage and/or function; however, current cell-ablation models have limitations. Intermedilysin (ILY), a cytolytic pore-forming toxin that is secreted by
Dechun Feng, Shen Dai, Fengming Liu, Yosuke Ohtake, Zhou Zhou, Hua Wang, Yonggang Zhang, Alison Kearns, Xiao Peng, Faliang Zhu, Umar Hayat, Man Li, Yong He, Mingjiang Xu, Chunling Zhao, Min Cheng, Lining Zhang, Hong Wang, Xiaofeng Yang, Cynthia Ju, Elizabeth C. Bryda, Jennifer Gordon, Kamel Khalili, Wenhui Hu, Shuxin Li, Xuebin Qin, Bin Gao
Hemodynamic shear forces are intimately linked with cardiac development, during which trabeculae form a network of branching outgrowths from the myocardium. Mutations that alter Notch signaling also result in trabeculation defects. Here, we assessed whether shear stress modulates trabeculation to influence contractile function. Specifically, we acquired 4D (3D + time) images with light sheets by selective plane illumination microscopy (SPIM) for rapid scanning and deep axial penetration during zebrafish morphogenesis. Reduction of blood viscosity via
Juhyun Lee, Peng Fei, René R. Sevag Packard, Hanul Kang, Hao Xu, Kyung In Baek, Nelson Jen, Junjie Chen, Hilary Yen, C.-C. Jay Kuo, Neil C. Chi, Chih-Ming Ho, Rongsong Li, Tzung K. Hsiai
Here, we have described and validated a strategy for monitoring skeletal muscle protein synthesis rates in rodents and humans over days or weeks from blood samples. We based this approach on label incorporation into proteins that are synthesized specifically in skeletal muscle and escape into the circulation. Heavy water labeling combined with sensitive tandem mass spectrometric analysis allowed integrated synthesis rates of proteins in muscle tissue across the proteome to be measured over several weeks. Fractional synthesis rate (FSR) of plasma creatine kinase M-type (CK-M) and carbonic anhydrase 3 (CA-3) in the blood, more than 90% of which is derived from skeletal muscle, correlated closely with FSR of CK-M, CA-3, and other proteins of various ontologies in skeletal muscle tissue in both rodents and humans. Protein synthesis rates across the muscle proteome generally changed in a coordinate manner in response to a sprint interval exercise training regimen in humans and to denervation or clenbuterol treatment in rodents. FSR of plasma CK-M and CA-3 revealed changes and interindividual differences in muscle tissue proteome dynamics. In human subjects, sprint interval training primarily stimulated synthesis of structural and glycolytic proteins. Together, our results indicate that this approach provides a virtual biopsy, sensitively revealing individualized changes in proteome-wide synthesis rates in skeletal muscle without a muscle biopsy. Accordingly, this approach has potential applications for the diagnosis, management, and treatment of muscle disorders.
Mahalakshmi Shankaran, Chelsea L. King, Thomas E. Angel, William E. Holmes, Kelvin W. Li, Marc Colangelo, John C. Price, Scott M. Turner, Christopher Bell, Karyn L. Hamilton, Benjamin F. Miller, Marc K. Hellerstein
Magnetic resonance–guided focused ultrasound (MRgFUS) facilitates noninvasive image-guided conformal thermal therapy of cancer. Yet in many scenarios, the sensitive tissues surrounding the tumor constrain the margins of ablation; therefore, augmentation of MRgFUS with chemotherapy may be required to destroy remaining tumor. Here, we used 64Cu-PET-CT, MRI, autoradiography, and fluorescence imaging to track the kinetics of long-circulating liposomes in immunocompetent mammary carcinoma–bearing FVB/n and BALB/c mice. We observed a 5-fold and 50-fold enhancement of liposome and drug concentration, respectively, within MRgFUS thermal ablation–treated tumors along with dense accumulation within the surrounding tissue rim. Ultrasound-enhanced drug accumulation was rapid and durable and greatly increased total tumor drug exposure over time. In addition, we found that the small molecule gadoteridol accumulates around and within ablated tissue. We further demonstrated that dilated vasculature, loss of vascular integrity resulting in extravasation of blood cells, stromal inflammation, and loss of cell-cell adhesion and tissue architecture all contribute to the enhanced accumulation of the liposomes and small molecule probe. The locally enhanced liposome accumulation was preserved even after a multiweek protocol of doxorubicin-loaded liposomes and partial ablation. Finally, by supplementing ablation with concurrent liposomal drug therapy, a complete and durable response was obtained using protocols for which a sub-mm rim of tumor remained after ablation.
Andrew W. Wong, Brett Z. Fite, Yu Liu, Azadeh Kheirolomoom, Jai W. Seo, Katherine D. Watson, Lisa M. Mahakian, Sarah M. Tam, Hua Zhang, Josquin Foiret, Alexander D. Borowsky, Katherine W. Ferrara
Increased sodium influx via incomplete inactivation of the major cardiac sodium channel NaV1.5 is correlated with an increased incidence of atrial fibrillation (AF) in humans. Here, we sought to determine whether increased sodium entry is sufficient to cause the structural and electrophysiological perturbations that are required to initiate and sustain AF. We used mice expressing a human NaV1.5 variant with a mutation in the anesthetic-binding site (F1759A-NaV1.5) and demonstrated that incomplete Na+ channel inactivation is sufficient to drive structural alterations, including atrial and ventricular enlargement, myofibril disarray, fibrosis and mitochondrial injury, and electrophysiological dysfunctions that together lead to spontaneous and prolonged episodes of AF in these mice. Using this model, we determined that the increase in a persistent sodium current causes heterogeneously prolonged action potential duration and rotors, as well as wave and wavelets in the atria, and thereby mimics mechanistic theories that have been proposed for AF in humans. Acute inhibition of the sodium-calcium exchanger, which targets the downstream effects of enhanced sodium entry, markedly reduced the burden of AF and ventricular arrhythmias in this model, suggesting a potential therapeutic approach for AF. Together, our results indicate that these mice will be important for assessing the cellular mechanisms and potential effectiveness of antiarrhythmic therapies.
Elaine Wan, Jeffrey Abrams, Richard L. Weinberg, Alexander N. Katchman, Joseph Bayne, Sergey I. Zakharov, Lin Yang, John P. Morrow, Hasan Garan, Steven O. Marx
Optical imaging of whole, living animals has proven to be a powerful tool in multiple areas of preclinical research and has allowed noninvasive monitoring of immune responses, tumor and pathogen growth, and treatment responses in longitudinal studies. However, fluorescence-based studies in animals are challenging because tissue absorbs and autofluoresces strongly in the visible light spectrum. These optical properties drive development and use of fluorescent labels that absorb and emit at longer wavelengths. Here, we present a far-red absorbing fluoromodule–based reporter/probe system and show that this system can be used for imaging in living mice. The probe we developed is a fluorogenic dye called SC1 that is dark in solution but highly fluorescent when bound to its cognate reporter, Mars1. The reporter/probe complex, or fluoromodule, produced peak emission near 730 nm. Mars1 was able to bind a variety of structurally similar probes that differ in color and membrane permeability. We demonstrated that a tool kit of multiple probes can be used to label extracellular and intracellular reporter–tagged receptor pools with 2 colors. Imaging studies may benefit from this far-red excited reporter/probe system, which features tight coupling between probe fluorescence and reporter binding and offers the option of using an expandable family of fluorogenic probes with a single reporter gene.
Ming Zhang, Subhasish K. Chakraborty, Padma Sampath, Juan J. Rojas, Weizhou Hou, Saumya Saurabh, Steve H. Thorne, Marcel P. Bruchez, Alan S. Waggoner
Cyclic dinucleotides (CDNs) are agonists of stimulator of IFN genes (STING) and have potential as vaccine adjuvants. However, cyclic di-GMP (cdGMP) injected s.c. shows minimal uptake into lymphatics/draining lymph nodes (dLNs) and instead is rapidly distributed to the bloodstream, leading to systemic inflammation. Here, we encapsulated cdGMP within PEGylated lipid nanoparticles (NP-cdGMP) to redirect this adjuvant to dLNs. Compared with unformulated CDNs, encapsulation blocked systemic dissemination and markedly enhanced dLN accumulation in murine models. Delivery of NP-cdGMP increased CD8+ T cell responses primed by peptide vaccines and enhanced therapeutic antitumor immunity. A combination of a poorly immunogenic liposomal HIV gp41 peptide antigen and NP-cdGMP robustly induced type I IFN in dLNs, induced a greater expansion of vaccine-specific CD4+ T cells, and greatly increased germinal center B cell differentiation in dLNs compared with a combination of liposomal HIV gp41 and soluble CDN. Further, NP-cdGMP promoted durable antibody titers that were substantially higher than those promoted by the well-studied TLR agonist monophosphoryl lipid A and comparable to a much larger dose of unformulated cdGMP, without the systemic toxicity of the latter. These results demonstrate that nanoparticulate delivery safely targets CDNs to the dLNs and enhances the efficacy of this adjuvant. Moreover, this approach can be broadly applied to other small-molecule immunomodulators of interest for vaccines and immunotherapy.
Melissa C. Hanson, Monica P. Crespo, Wuhbet Abraham, Kelly D. Moynihan, Gregory L. Szeto, Stephanie H. Chen, Mariane B. Melo, Stefanie Mueller, Darrell J. Irvine
Current strategies to alter disease-associated epigenetic modifications target ubiquitously expressed epigenetic regulators. This approach does not allow specific genes to be controlled in specific cell types; therefore, tools to selectively target epigenetic modifications in the desired cell type and strategies to more efficiently correct aberrant gene expression in disease are needed. Here, we have developed a method for directing DNA methylation to specific gene loci by conjugating catalytic domains of DNA methyltransferases (DNMTs) to engineered transcription activator–like effectors (TALEs). We demonstrated that these TALE-DNMTs direct DNA methylation specifically to the targeted gene locus in human cells. Further, we determined that minimizing direct nucleotide sequence repeats within the TALE moiety permits efficient lentivirus transduction, allowing easy targeting of primary cell types. Finally, we demonstrated that directed DNA methylation with a TALE-DNMT targeting the
Diana L. Bernstein, John E. Le Lay, Elena G. Ruano, Klaus H. Kaestner
Adoptive transfer of tumor-reactive T cells can successfully reduce tumor burden; however, in rare cases, lethal on-target/off-tumor effects have been reported. A noninvasive method to track engineered cells with high sensitivity and resolution would allow observation of correct cell homing and/or identification of dangerous off-target locations in preclinical and clinical applications. Human deoxycytidine kinase triple mutant (hdCK3mut) is a nonimmunogenic PET reporter that was previously shown to be an effective tool to monitor whole-body hematopoiesis. Here, we engineered a construct in which hdCK3mut is coexpressed with the anti-melanoma T cell receptor F5, introduced this construct into human CD34 cells or PBMCs, and evaluated this approach in multiple immunotherapy models. Expression of hdCK3mut allowed engrafted cells to be visualized within recipient bone marrow, while accumulation of [18F]-L-FMAU in hdCK3mut-expressing T cells permitted detection of intratumoral homing. Animals that received T cells coexpressing hdCK3mut and the anti-melanoma T cell receptor had demonstrably higher signals in HLA-matched tumors compared with those in animals that received cells solely expressing hdCK3mut. Engineered T cells caused cytotoxicity in HLA/antigen-matched tumors and induced IFN-γ production and activation. Moreover, hdCK3mut permitted simultaneous monitoring of engraftment and tumor infiltration, without affecting T cell function. Our findings suggest that hdCK3mut reporter imaging can be applied in clinical immunotherapies for whole-body detection of engineered cell locations.
Melissa N. McCracken, Dimitrios N. Vatakis, Dhaval Dixit, Jami McLaughlin, Jerome A. Zack, Owen N. Witte
Respiratory syncytial virus (RSV) is the most common cause of serious viral bronchiolitis in infants, young children, and the elderly. Currently, there is not an FDA-approved vaccine available for RSV, though the mAb palivizumab is licensed to reduce the incidence of RSV disease in premature or at-risk infants. The palivizumab epitope is a well-characterized, approximately 24-aa helix-loop-helix structure on the RSV fusion (F) protein (F254–277). Here, we genetically inserted this epitope and multiple site variants of this epitope within a versatile woodchuck hepadnavirus core–based virus-like particle (WHcAg-VLP) to generate hybrid VLPs that each bears 240 copies of the RSV epitope in a highly immunogenic arrayed format. A challenge of such an epitope-focused approach is that to be effective, the conformational F254–277 epitope must elicit antibodies that recognize the intact virus. A number of hybrid VLPs containing RSV F254–277 were recognized by palivizumab in vitro and elicited high-titer and protective neutralizing antibody in rodents. Together, the results from this proof-of-principle study suggest that the WHcAg-VLP technology may be an applicable approach to eliciting a response to other structural epitopes.
Jeanne H. Schickli, David C. Whitacre, Roderick S. Tang, Jasmine Kaur, Heather Lawlor, Cory J. Peters, Joyce E. Jones, Darrell L. Peterson, Michael P. McCarthy, Gary Van Nest, David R. Milich


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EASTON, Pa. (AP) - February 9, 2013 --Police in eastern Pennsylvania say they believe that an early morning shooting death in an Easton bar may have been gang related.
Officials said a man was shot at about 12:15 a.m. Saturday in Eddie G's Bar and died shortly afterward at a hospital.
Police said the shooting followed an argument among a number of people believed to have been gang members originally from Newark, N.J.
One man who ran out the front of the bar and another man who fled out the back are being sought.
Northampton county Coroner Zachary Lysek ruled the death of the victim a homicide. His name has not been released pending notification of relatives.


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Box Office: Texas Chainsaw 3D Kills the Competition
Jan 6, 2013 6:46 PM EST
Moviegoers rang in the new year with a lot of blood. Texas Chainsaw 3D grabbed the top spot at the weekend box office, grossing an estimated $23 million in its opening weekend, Box Office Mojo reports. Django Unchained took No. 2 with a little over $… Read more


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Michelle Yeoh honored at Asian Film Awards
Mar. 18, 2013
HONG KONG (AP) — Michelle Yeoh is happy to be honored with the "Excellence in Asian Cinema Award" but says she hopes there's no hidden message.
She asked, "I hope it's not their way of telling me that I need to retire?"
The star of "Crouching Tiger, Hidden Dragon" and last year's Aung San Suu Kyi biopic "The Lady" is being honored at the Asian Film Awards on Monday night.
Speaking to reporters a day earlier, Yeoh said she's happy to receive the award where her career started, in Hong Kong.
And while she acknowledged she's long heard rumors of a "Crouching Tiger" sequel, she says she's yet to see a script or other plans on the project. The 2000 original was directed by Ang Lee and won four Academy Awards.
The recent reports have attached kung fu star Donnie Yen to the unconfirmed sequel, and Yeoh said she's a fan and would welcome the opportunity to work with him if a project is developed.
The Hong Kong film festival's opener Sunday was "Ip Man: the Final Fight," the latest film about martial arts master Ip Man. Lead actor Anthony Wong and actress Zhou Chou Chou were among stars walking the red carpet.
Veteran Hong Kong directors Johnnie To and Ronny Yu are also premiering works at the festival, which features "Infernal Affairs" director Andrew Lau.
The festival closes in April with the Iranian film "Closed Curtain," which is fresh off a win for best script at the Berlin Film Festival.


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Junior Fellows
"I just wanted to take a minute to thank you for the opportunity to have been a Salvatori Jr. Fellow. It has been very interesting sitting in on the lectures and chats with the speakers this semester, and I feel privileged to have had the opportunity." - Former Salvatori Junior Fellow
Each year, the Salvatori Center sponsors more than a dozen talks by eminent writers, scholars, politicians, and journalists. Salvatori Junior Fellows have the chance to meet privately with these speakers for an informal discussion which excludes faculty or administrators. These intimate conversations often precede the speaker's talk at the Athenaeum or occur over lunch or some other social event.
Successful applicants for a Salvatori Junior Fellowship will demonstrate a high level of academic achievement and a strong interest in public affairs. Selected students carry the title of Junior Fellow for one semester, and will be eligible for reappointment in the following semester.
Once chosen, Junior Fellows are expected to attend the sponsored discussions and social occasions (some of which will be kept deliberately small, so that taking turns among the Fellows may be necessary). Junior Fellows are also expected to attend all or nearly all of the speakers' public presentations.
Please submit the following if you wish to apply:
1) A completed application form
2) An up-to-date résumé
3) CMC transcript (working copy permissible)
For more information, please contact Administrative Assistant Elvia Huerta or Director Mark Blitz.


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BabesofMMA just alerted us to a new photo shoot from Louisiana model/ring girl Laura Moro, and there isn't much to say outside of hnnnnng.
Props to Trick Productions for the lovely pics. More new photos of Laura are in the gallery above. See more of Ms. Moro on Facebook and Twitter.


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DC DMV will be closed in honor of Independence Day on Wednesday, July 4. We will reopen for business on Thursday, July 5.
Every year, close to 600,000 sites are hacked by people trying to distribute malware, peddle fake goods or phish users. Given the scale of the problem, notifying users to prevent harm and webmasters so they can clean up their sites is critical to combat hacking. This post looks at the effectiveness of the current warning strategies used by Google and other companies, and their long-term impact. This blog post is a summary of the study on the effectiveness of notification strategies for hacked sites that we ran at Google in partnership with the University of California, Berkeley. Our goal was to understand how we can improve our notifications so we reach more webmasters and help them clean up their sites faster and more efficiently. The full study results are available in a research paper , which was published at WWW16 and Kurt Thomas wrote a summary in his Google blog post . We will start by briefly summarizing why sites are hacked and who is getting hacked. Then we will discuss warning strategies for users followed by notification strategies for webmasters and we will conclude with what you can do to help.
Websites are mainly hacked for the following three reasons:
For our study, we looked at the 760,935 hacking incidents we detected between July 2014 and June 2015. Those incidents affected 579,932 sites, with some sites being involved in multiple incidents.
From the chart above, we observe that more sites are hacked for malware and phishing purposes than for blackhat SEO reasons. However, we detected more blackhat SEO incidents, which indicates that websites hacked for SEO purposes tend to be hacked multiple times. This is partially because SEO backdoors are hard to clean up because they are added to many legitimate pages. For example, some backdoors will modify the code of all the WordPress plugins installed.
Over the last year, as visible in the graph above, the number of phishing sites that Safe Browsing detected kept increasing, reaching an all-time high in 2016. The trends and more information about how many malicious sites have been detected are available on the Google Safe Browsing transparency report .
As soon as a page is detected as being compromised, it is added to the Google Safe Browsing API . This API is used by Chrome, Safari, Firefox and many websites such as bit.ly to know wen to warn users. For example, the screenshot below shows the warning that Chrome will display when you attempt to visit a page that has been added to Safe Browsing.
The Google Safe Browsing API offers protection against malware, social engineering like phishing, unwanted software and potentially harmful applications . Beside web pages, the Safe Browsing API protects also against bad binaries including software that plasters web pages with ads which are detected as unwanted software .
The chart above, taken from the Google Safe Browsing transparency report, shows that millions of users are protected by Safe Browsing. For example, for the week beginning March 27, 2016, a total of 57,101,380 users saw a warning.
To ensure that users pay attention to these warnings, the Chrome team has invested a lot of effort into optimize them to reduce the number of people clicking through so they dont got harmed. They tried many design, including the one depicted above
Safe Browsing is also used in Google Search results to prevent users from accessing compromised websites while searching for information. The screenshot above is from the 8th page of the results for a search. It indicates that the page has been hacked and users are not able to click the link.
The chart above is also from the Safe Browsing transparency report. You can see that every week, tens of millions of search results are marked as hacked. For example, for the week beginning May 15, 2016, altogether 42,028,563 search results had a warning.
Google can notify webmasters of a compromise in two ways. If the webmaster has a Webmaster Tools account , they are contacted via the search console as illustrated above. If the webmaster does not use Google Webmaster Tools, then we try to contact them through the email address listed in WHOIS.
Between July 2014 and June 2015, we sent 139,818 notifications via the Search Console alerts and 336,122 notifications via the email address on WHOIS, as visible in the chart above.
Is notifying webmaster effective? Yes i is: when webmasters are notified, blue line on the chart above, they are able to clean up their sites faster than when they are not notified, orange line on the chart.
We observe that the notifications sent through the search console are the best one both in term of reaction time and clean up percentage. Browser warnings are a distant second and search warning is the least effective. This indicate that having the ability to reach webmaster effectively is essential to make notification helpful. This is why in attempt to reach webmasters faster Safe Browsing notification are now integrated with Google analytics as visible in the screenshot below.
As mentioned earlier in the post, a key challenge with cleaning websites up is making sure that not only the symptom is removed, e.g., the phishing page, but the root cause is addressed as well. We have found that a good fraction of sites 22% of those hacked for SEO purposes and 6% of those hacked for malware and phishing purposes are not completely cleaned up and are hacked again. These numbers show how important it is to develop tools and documentation to help webmasters clean up an infected site. It also suggests that SEO backdoors are harder to remove, as they infect many pages of a site.
As an internet user : If you are a user, please do not ignore the warnings. There is a real risk that you will become compromised, phished or tricked if you ignore and proceed to the site. As a webmaster : If you are a webmaster, please register with the Webmaster Tools so we can contact you easily if your site is hacked. You should also make sure the email address for your domain in WHOIS is correct so people can contact you if needed. As always, also keep your software up to date to prevent hackers from exploiting old vulnerabilities to hack your site. As a social media user : Share and like this post, so we reach as many webmasters as possible! Let me know what you think is the best way to notify webmasters and what else the security community should be doing to keep the internet a safe place.
For shallots: Vegetable oil for frying 2 small shallots, thinly sliced 1/4 teaspoon salt
For hummus: 1 large (19-ounce) can white beans (e.g. cannellini), rinsed and drained 2 tablespoons lemon juice 2 tablespoons tahini 1 clove garlic 1/2 teaspoon dried oregano 1/4 teaspoon salt 1/8 teaspoon freshly ground black pepper 1/3 cup olive oil, plus more for garnish
1) Fill a small, cold skillet with about 1/4-inch of vegetable oil. Add shallots and turn heat to medium-high. Cook until browned and crispy, 6–8 minutes.
2) Meanwhile, combine all hummus ingredients except oil in food processor; turn machine on and pour the oil into the mixture in a smooth stream. Process until smooth. Transfer hummus to a bowl and top with shallots and an additional drizzle of oil.
Grilled Tzimmes
Re-create the flavors of this Rosh Hashana mainstay on your backyard grill. Serves 4
2 sweet potatoes, peeled and cut into 1/4-inch rounds 2 carrots, halved vertically and cut into 1-inch pieces 3 apricots, halved and pitted 2 red pears, cored and quartered 4 tablespoons olive oil, divided 2 tablespoons brown sugar 1 teaspoon cider vinegar Salt and freshly ground black pepper 3 tablespoons raisins (optional)
1) Preheat grill or grill pan to medium heat. In a large bowl, toss sweet potatoes, carrots, apricots and pears with 2 tablespoons oil and salt and pepper to taste.
2) Grill vegetables and fruit in batches, starting with the sweet potatoes and carrots (about 8 minutes, covered and turning once), followed by the apricots and pears (4-5 minutes, turning once). Arrange grilled vegetables and fruits on a platter.
3) Whisk together brown sugar, cider vinegar, remaining 2 tablespoons oil and salt and pepper to taste in a small bowl. Drizzle dressing over the vegetables and sprinkle with raisins, if using.
Leah Koenig is a freelance writer who's work has appeared in The New York Times Magazine, Saveur, Gastronomica and Food Arts, among others. She also contributes a monthly column called Ingredients to The Forward, and is a former employee of Hazon where she edited The Jew The Carrot. The Hadassah Everyday Cookbook: Daily Meals for the Contemporary Jewish Kitchen (Rizzoli March, 2011) is her first cookbook.SUPPORT FEARLESS JOURNALISM
Join thousands of readers and give today to help fund the Forward 's reliable reporting, intelligent analysis, and a Jewish voice you cantrust on news, culture, lifestyle and opinion. Thank you for making agenerous donation now.
More and more fields are using 3D printing technology for parts production, which makes the availability of advanced materials increasingly important. Material scientists from both Polymaker and Covestro suggest that U1000 and U0174D, both of which have several unique features, can be used to provide solutions for a wide range of new applications, which means new customers, as well as contributing "to the further penetration of AM into a variety of industrial markets."
Dr. Xiaofan Luo, President of Polymaker, said, "We are very excited about these two materials.They will certainly enable lots of new applications and open opportunities in a variety of industries."
U1000 and U0174D are boththermoplastic polyurethanes, or TPUs – a particular specialty of Covestro, which is actually an independent subgroup within the Bayer company and used to be known as Bayer MaterialScience. TPU allows for permanent bonding between layers that are being 3D printed, and due to its elastic nature, offers great flexibility and abrasion resistance.
Wang said, "Polyurethane is an incredibly versatile chemistry that can be used to create almost endless possibilities in materials."
While most conventional TPUs are rubbery and soft, the newU1000 and U0174D materials are tough and strong, just like engineering plastics. Both of these versatile materials have good heat resistance, layer adhesion, and mechanical strength, and can be used to print durable parts for manufacturing environments, like jigs and fixtures, molds, structural components, and tools.
U1000 and U0174D differ from other high-performance plastics in that they don't require demanding printing conditions, such as high chamber and nozzle temperatures: they can both be printed, on almost any thermoplastic extrusion-based 3D printer, under much more mild conditions. However, there are a few major differences between these new materials. Ductile U0174D feels more likea semi-crystalline plastic, likepolypropylene, and has excellent fracture toughness, while still U1000 has a high modulus, such as glassy polymers likepolystyrene and polycarbonate.
What do you think of these new materials? Discuss this and other 3D printing topics at 3DPrintBoard.com or share your thoughts in the Facebook comments below.
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• polyurethane • strong materials • thermoplastic • SELOVO 925 Sterling Silver Star Earring Cuff Ear Climber Cubic Zirconia Crystal Stud for Girls Women m0AAXTP
The impetus behind the change? "It's clear the community wants retailtainment," said Barnes Noble Vice President of Development David Deason in
Black Spring Large Circle Clip on Earrings for Girls Women Non Pierced Invisible DIY Earrings QRlV3r0gTg
. "This is a departure for us. It's not grab-and-go, but sit-and-stay."
This "sit-and-stay" idea is what brick and mortar retailers can take from Barnes Noble's retailtainment concept.
One of the central tenets behind retailtainment is the notion that the longer people spend in your store(s), the more likely they are to purchase something. So focus your retailtainment strategy on a particular area (to throw it back to our first point), and make sure that area is something that'll entice customers to "sit-and-stay" rather than "grab-and-go."
National Geographic and iP2Entertainment are in the process of developing two "museum retail" locations in China.
According to a National Geographic press release , the Shenyang and Hengqin centers (with the former set to open in summer 2017) will "offer a unique opportunity to play and explore through themed attractions, interactive demonstrations, and hands-on workshops in a fun and immersive environment that ignites kids' curiosity about the world."
The National Geographic-branded "Museum Retail" locations will fuse education with retail, and a portion of the proceeds will go to the National Geographic Society's nonprofit work.
It's this last part that we think brick and mortar retailers can take to heart. If you have the means, incorporate a charity element into your retailtainment experience . Customers will be more likely to get involved if they feel like they're contributing to a good cause.
We hope these retailtainment examples have shed some light on the kinds of experiences consumers are looking for. Have you come across any compelling retailtainment concepts recently? Let us know in the comments!
Nikki is Vend's content and copy wizard. American-born and Auckland-based, she's into reading (a lot), writing (obviously), and travelling (always).
If the new consumer shops differently; unique "Retailtainment " can certainly be the difference maker in hacking and growing your retail business.
Really enjoyed this piece Nikki. How effective do you think live events, free product give aways and offering educational aspects to a store's retail audience can be at boosting in-store traffic and especially increasing customer retention?
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Impactology™ for iPhone 5 hits Apple Stores across Europe
Jan 23, 2013, 01:15 EST
LONDON, January 23, 2013 /PRNewswire/ --
Tech21, the maker of Impactology™ approved cases for mobile devices, announced that their iPhone 5 Impact Band and Impact Mesh cases will be available from Apple Stores and Apple.com across Europe from January 23rd 2013.
(Photo: http://photos.prnewswire.com/prnh/20130123/589339-a )
(Logo: http://photos.prnewswire.com/prnh/20130123/589339-b )
Unlike other cases, Tech21 is the only brand to offer Impactology™ approved cases which provide unrivalled protection to mobile devices thanks to the unique polymer material, D3O®, which is inside each Tech21 Impact Band and Impact Mesh case. Customers can chose from a range of colours including Smokey, Clear and Pink in the Impact Band design, which is similar in appearance to the famous Bumper style of the iPhone 4. Impact Mesh, which although similar to the Impact Band from the front, also features a mesh design to back, making the case 5 sided, and will be available in Blue and Pink so customers can pick the design and colour to suit their style. Each case provides maximum protection but still gives access to all the functionality, ports and buttons that have made this a must-have phone.
"Apple customers insist on having the highest standard in design, performance and innovation, and we are confident our ImpactologyTM approved cases meet that expectation," said Jason Roberts, CEO of Tech21. "Our unique Impactology™ technology will give customers ultimate impact protection when they need it most so we are very excited to have 5 of our most attractive cases launching into Apple stores globally."
What is Impactology™
Tech21 have turned Impact Protection into a science, establishing Impactology™ as a defining seal of approval. All Tech21 Impactology™ cases have been developed over many years of intensive research, including the study of impact protection, the use of D3O® a unique patented shock absorbing material, unique fabrics and their application, resulting in a highly specialised and complex manufacturing process.
Features of Impactology™ approved cases
- Proven Impact Protection materials specifically chosen to provide the maximum protection against drops and spills for your mobile device
- Slim and sleek design - because of the quality of Impact Protection materials used, we don't need huge amounts of material that can otherwise create bulky cases
- All our cases are designed to ensure full access and functionality of your device
For more information about Where to Buy visit http://www.tech21.uk.com.
To find out more about the Impactology™ story visit http://www.tech21.uk.com/impactology/what_is_impactology
SOURCE Adrenalin


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See what questions
a doctor would ask.
Twitching of the lip: jerk usually caused by sudden muscle contractions. See detailed information below for a list of 5 causes of Twitching of the lip, including diseases and drug side effect causes.
» Review Causes of Twitching of the lip: Causes
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The list below shows some of the causes of Twitching of the lip mentioned in various sources:
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This information refers to the general prevalence and incidence of these diseases, not to how likely they are to be the actual cause of Twitching of the lip. Of the 5 causes of Twitching of the lip that we have listed, we have the following prevalence/incidence information:
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The following list of conditions have 'Twitching of the lip' or similar listed as a symptom in our database. This computer-generated list may be inaccurate or incomplete. Always seek prompt professional medical advice about the cause of any symptom.
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Fasiculations, Kennedy disease, Lower motor neuron disease, Amyotropic lateral sclerosis, Organophosphate poisoning, Benzodiazepine poisoning, Myasthenia gravis, Lyme disease, Dehydration (284 causes), Fatigue (3235 causes), Myalgic encephalopmyelitis
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Copyright © 2014 Health Grades Inc. All rights reserved. Last Update: 13 August, 2015 (0:24)


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Actor Dean Cain has paid tribute to his former Stars Earn Stripes mentor, retired Navy SEAL Chris Kyle, following his sudden death on Saturday.
The marksman was shot dead at a gun range in Glen Rose, Texas. A former Marine, Eddie Ray Routh, has been charged with his murder.
Now Cain, who was paired with Kyle on the 2012 reality series, which showed members of the Armed Forces training celebrities to compete in various challenges for charity, has spoken out in the wake of the tragedy.
In a post on Twitter.com, the Lois & Clark: The New Adventures of Superman star writes, "2013 started out fantastic…Now it's a heartbreak. Sad Day."
Pop singer Nick Lachey, who also appeared on the program, added, "Devastated to hear of the murder of chris kyle. i was honored to have spent time with him…..a TRUE American hero. senseless. RIP CHRIS," and fellow participant actor Terry Crews tweeted, "Can't believe the news about my good friend Chris Kyle, the best sniper in the U.S. military. God bless his soul."
Meanwhile, former presidential hopeful Sarah Palin, whose husband Todd was also a contestant on the show, has released a statement on her Facebook.com page paying tribute to Kyle.
In a post, she writes, "Our thoughts and prayers go out to the family and many friends of former Navy SEAL Chris Kyle tonight. Todd and I first met Chris in Pella, Iowa, when he helped out with security for the premiere of the film The Undefeated. And later we became friends with Chris when he was on Stars Earn Stripes with Todd. Chris was a wonderful man, a good friend, and a true American hero who loved our country and served honorably. He was loved and admired by so many, and he will never be forgotten."
Actor Dean Cain has paid tribute to his former Stars Earn Stripes mentor, retired Navy SEAL Chris Kyle, following his sudden death on Saturday.


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Boeing, one of the 30 large companies in the Dow Jones industrial average, said it expects to deliver more airplanes and raised its estimates for profits this year. Boeing's quarterly earnings also beat analysts' estimates. Its stock rose $1, or 1.4 per cent, to $73.82.
The Dow climbed 9 points to 13,111 shortly after noon. The Standard & Poor's 500 index slipped less than one point to 1,412 while the Nasdaq composite index sank seven points to 2,983.
"Today we're assessing the damage," said Mark Luschini, chief investment strategist at Janney Montgomery Scott. "Everybody just got clobbered yesterday."
Lower corporate revenue and expectations for the rest of the year drove the Dow down 243 points Tuesday, its third-biggest drop this year. DuPont, 3M, UPS and Xerox all reported lower sales than a year ago.
"It seemed out of the blue, but what we were seeing was stock prices adjusting to corporate profitability," Luschini said.
Facebook was poised for its best day since its stock market debut in May. The company said late Tuesday that 14 per cent of its advertising revenue came from mobile devices, allaying some investor concerns.
The social network's stock soared $3.91 to $23.44, a jump of 20 per cent. Facebook has swung widely since its IPO at $38, and has traded as low as $17.55.
Another Dow stock, AT&T, said it added the fewest wireless customers since 2003, far behind Verizon Wireless. AT&T's results still managed to beat the estimates of financial analysts. AT&T fell 25 cents to $34.75.
A measure of manufacturing in China, the world's second-largest economy after the United States, improved this month to a three-month high. China's white-hot economic growth has been slowing.
In the U.S., bond prices inched lower, sending yields up. The yield on the benchmark 10-year Treasury note edged up to 1.77 per cent from 1.76 per cent late Tuesday.
Among other stocks in the news:
— Netflix plunged $10.13 a share, 15 per cent, to $58.06. Late Tuesday, it slashed its prediction for how many U.S. video-streaming subscribers it would add this year to 4.7 million to 5 million. It had predicted it would add as many as 7 million.
— Dow Chemical rose $1.70 to $30.25. The company announced a wide-ranging restructuring plan late Tuesday that includes cutting 2,400 jobs and closing 20 manufacturing facilities. The company cited slowing economic growth in Europe and elsewhere.
— Tempur-Pedic plunged $6.93 to $24.94, a loss of 22 per cent. The maker of premium memory foam mattresses reported revenue that was well below the estimates of Wall Street analysts. The company also cut its estimates for full-year profits and revenue.


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The best way to keep up to date with Buckingham RUFC
Floyd Field Maids Moreton Buckingham Buckinghamshire MK18 1RF View with Google Maps
This website is part of the Pitchero Rugby Union network. Create your own free Rugby Union club website with Pitchero.
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Pitch Hero Ltd Registered in ENGLAND | WF3 1DR | Company Number - 636 1033


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Click on the 'SPEAKER' button to hear
the sentence, and then type in your response where the cursor is flashing.
You can hear the sentence as many times as you want. Use the HINT button
to help you with your spelling. If you can't get a word, click on the "????"
and you will see the word, but you will lose marks! After five sentences
you will see your total score. There are ten sentences in all, so if you
try it again you may or may not get the same sentences as the first time.
Have fun!
Return to...
- Last updated: June 16, 1997 -


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I'm Suing Over ObamaCare Exemptions for Congress
If the president wants to change the health-care law, he must ask Congress to do it.
On Monday, Jan. 6, I am filing suit in the U.S. District Court for the Eastern District of Wisconsin to make Congress live by the letter of the health-care law it imposed on the rest of America. By arranging for me and other members of Congress and their staffs to receive benefits intentionally ruled out by the Patient Protection and Affordable Care Act, the administration has exceeded its legal authority.
The president and his congressional supporters have also broken their promise to the American people that ObamaCare was...


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Williamstown students recently celebrated See You At The Pole, a global day of student prayer that began in 1990 as a grass roots movement. Twenty years later, millions pray on their campuses on the fourth Wednesday in September. During the prayer rally, students meet at the school flagpole before school to sing and pray.
If you currently subscribe or have subscribed in the past to the Grant County News, then simply find your account number on your mailing label and enter it below.
Click the question mark below to see where your account ID appears on your mailing label.
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text: We're making some upgrades behind the scenes today. Beginning this morning at 9:30 a.m. ET, all community features will be disabled (commenting, favoriting, and new submissions to Talk and Photograzing). We expect the upgrade to take approximately 3 hours and as soon as it is complete, community features will be restored. Thanks for your patience!


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This coming weekend (Nov 14th if you are want to learn) Marshall Vandruff is joining us to teach his awesome class on creating anatomy from imagination, and constructing believable figures and characters from any perspective on the fly. This is the single best anatomy teacher I have ever found and a world renown instructor responsible for teaching guys like Justin Sweet, Bernie Wrightson, Drew Struzan , Kevin Llewellyn , Vance Kovacs artists from Blizzard, Sony, Disney and...the list goes on. And on. And on.
Without the knowledge of anatomy and structure shared with me from Marshall I would have struggled to do all the concept work I did over the years. He is one of the finest teachers I have ever encountered and I think you will find him to be the same. So that being said...here is some info!
ANATOMY FOR ARTISTS: An Introduction to Observe & Invent The Human Figure
Marshall offers this intensive crash-course that compares human anatomy in book plates with finished masterpieces by great artists. This workshop makes anatomy practical - knowledge that contributes to powerful life drawing and allows artists to invent figures from imagination.
The course includes over 200 slides of great art with commentary and comparisons between anatomy plates and finished works.
The course showcases the work and teaching of George Bridgman, and his influence on illustrators such as Frank Frazetta.
The roots of creative anatomy shall be revealed this weekend.
When: Nov 14th
How much: 95 USD
What time? 1pm-5pm PST
"I heard CA upgraded it's tech?" - Yep we sure did and it is really nice stuff. We have paid the price and shelled out for the leading on line education tools available. The system works great and is here to stay.
How? Direct Link to the store here! http://www.conceptartstore.com/anforar.html
Why? - Because you want to learn to better your anatomy use, create figures from life and/or imagination and because you want to be the best artist you can be.
Who is this for? This is for all artists no matter the discipline. If you are a 3d artist, 2d artist, painter, sculptor or any other artist using the human figure, then this class will help you. For certain.


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Brittany Sullivan
(850) 245-9724
PRESS RELEASE: Board of Governors seeks applicant for UF Board of Trustees
At a time when Florida is raising the bar on higher education and reaching for a new level of accountability, the Board of Governors is seeking applicants for a spot on the University of Florida's Board of Trustees.
This is a unique public service opportunity to shape the future of one of the country's best public institutions. Home to nearly 50,000 students, 16 colleges and more than 150 research centers and institutes, UF has the highest graduation and retention rates in the System, along with the state's highest endowment. It is also one of two preeminent universities in the state, as designated by the Florida Legislature, and is on the cusp of being one of the country's top 10 public universities.
Each state university has a 13-member Board of Trustees responsible for cost-effective policy and implementing and maintaining high-quality education programs consistent with the university's mission. Trustees also work to adhere to state policy, budgeting and education standards.
"Our trustees are essential to the State University System, ensuring that our universities are efficient and provide an excellent education," said Mori Hosseini, chair of the Board of Governors. "As a preeminent university, we fully expect that UF will be one of the country's top 10 public universities in the next five years. The trustee to serve in this position will have a huge role in steering that ship."
Those interested in this opportunity must complete an application with the Board of Governors' Trustee Nominating Committee by May 16, 2014 at 5 p.m. The term of service runs through Jan. 6, 2015.
More information is available at:http://www.flbog.edu/aboutsus/vacancies.php
Please send completed applications to:
Office of the Chancellor
Board of Governors
Attn: Corporate Secretary
325 W. Gaines Street, Suite 1614
Tallahassee, Florida 32399-0400
Fax : (850) 245-9685 or
Email : email@example.com
Board of Governors' trustee appointments are separate from appointments made by the Governor of Florida. For further questions, contact the Board of Governors at 850-245-0466. For more information about the Board and the State University System, visit http://www.flbog.edu/.
# # #
Facts about the State University System of Florida and Florida Board of Governors
The State University System of Florida is a constitutional body led by the 17-member Board of Governors. The system has 12 universities and more than 335,000 students, making it the second-largest public university system in the nation. Responsibilities include defining the distinctive mission of each institution and managing the system's coordination and operation. The Board appoints a Chancellor who serves as the system's chief executive. For more, visitwww.flbog.edu.


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Green Living
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Carbon Footprint Calculator
Answer a few questions and we'll estimate your impact and compare it to similar households.
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Save paper and give friends and family the opportunity to enjoy the wonder of nature from the comfort of their computer screen.
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- - Weighs approximately 0.7lbs/ 0.3kg
- Depth 1cm
- Handle Drop 46cm
- Height 18cm
- Width 10cm
Charlotte Olympia's accessories collection is as desirable as her celebrated shoe line, and this 'Baboushka' clutch is a covetable case in point. Inspired by traditional Russian dolls, this compact design is beautifully crafted from colorful embroidery and appliqué leather. Pick out your favorite hue and match it to your outfit to play up this chic piece's playful appeal.
Shown here with: Kain top, Kenneth Jay Lane bracelet, Yves Saint Laurent ring and shoes, Valentino skirt.
- - Multicolored leather (Kid)
- - Detachable gold chain shoulder strap
- - Matryoshka design, multicolored embroidery
- - Fully lined in black twill
- - Zip fastening with matryoshka doll zip pull
- - Comes with dust bag
Product Code: 313790
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As widely reported in the news, a Russian crime ring has allegedly stolen more than 1.2 billion username and password combinations, leaving the personal information of a large number of Internet users exposed. The stolen records, discovered by a security firm based in Milwaukee, include confidential information taken from roughly 420,000 websites varying in size and scope.
At this time there is no indication Penn State has been affected by this breach. University information technology staff continue to monitor Penn State systems and services for any sign of attack.
The University advises students, faculty and staff who have used their Penn State Access Account password for such non-Penn State services as personal email, financial institutions or online shopping websites, to change their Penn State password immediately to protect the privacy of their confidential information. Users can change their passwords by visiting https://www.work.psu.edu/password/.
Students, faculty and staff are encouraged to change all other passwords to further protect secure information. University guidelines for creating and saving strong, easy-to-remember passwords are available at http://its.psu.edu/be-safe/password-best-practices.
Penn State is dedicated to protecting student, faculty and staff information. Two-Factor Authentication (2FA), a security protocol used to verify user identification, is being explored for wider University implementation in the future. This protocol adds an additional step to the traditional login system (username and password only), requiring users to verify their identity with an additional credential. This robust, easy-to-use authentication service will provide an additional effective layer of protection to University information.
If you have questions or need assistance changing your password, contact the IT Service Desk at 814-865-4357.


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Ben Shaw has been a rider since August 2007, when, freshly returned from multiple combat tours with the US Marines in Iraq, he purchased a Yamaha Virago 250. Ten days later, dissatisfied with its small size, he purchased an 1100.
In 2008, Shaw rode cross-country, expecting to cover 5,500 miles in roughly a month. Four and a half months and 9,500 photographs later, he returned – having ridden 13,500 miles. Since then, he has undertaken several shorter rides, and looks forward to available time to cross the United States on a northern route.
Shaw's experience with riding is that there is danger, beautiful scenery, long, low curves through beautiful countryside, and a profusion of interesting people met along the way – often just as savory or unbelievable as the ride itself. The most important thing about biking, thus, is being simply curious about everything. Without fail, schedules never work, the weather never cooperates, weird and amazing people abound, but it all becomes the stuff of stories riders will tell for years to come. As any rider knows, strange things always happen on the road.
Shaw currently resides in Virginia, and works as a combat journalist and veteran advocacy writer.


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The Massage Therapy Program is available for employees, the public, patients and their families, as well as businesses in the community. The Program is designed to provide optimal access to professional massage that can enhance wellness through physical and mental relaxation and pain relief, improving the quality of life for all who receive services.All services are provided by Licensed Massage Therapists throughout multiple locations within the Medical Center and off-site locations D1 and Arbor Acres.View a massage therapist's interview with Fox 8 on Massage Therapy.
Learn more about the benefits of Massage Therapy and Pain by visiting the website.Related Links for Massage Therapy for Pain Management, Back Pain, etc. Types of massage available include:Chair Massage—A quick release of stress for the person always on the go. Swedish Massage— Table work, from head to toe, depending on time restraints chosen by the client. A great stress reliever.Deep Tissue Massage— Table work, involving deeper pressure (to client's tolerance level). Promotes the healing process of muscle tissue.Sports Massage—Table work at a quicker, more vigorous pace, to wake up tired muscles and get them ready to perform. Involves techniques stretching and joint mobilization.
Therapeutic Massage—Table work that is more point specific. Helps relieve pain and tension, improve range of motion, functionality and promotes the healing process.
Trigger Point Therapy—Table work that uses methods to assess and manipulate muscle tissue, in order to promote the healing and reprogramming of the neurological loop to reduce pain and improve functionality.
Myofascial Release—Table work, involving the stretching and elongating of connective tissue in and around the muscles. Helps to restore balance, health, and elasticity while relieving pain.
Prenatal/Postpartum—Table work, based on the premises of Swedish Massage, but catered to the changes, complications and precautions that come with pregnancy.
Infant Massage—Table work, based on the premises of Swedish Massage to help soothe and nurture children.
Reiki—Table work, that uses a system of treatment that channels universal healing energy through the therapist into and around the client's body, sometimes without direct hands-on contact.
Negative Pressure/Massage Cupping—Table work, based on Ancient Chinese techniques creating suction and negative pressure. This therapy is used to relax tight muscles, loosen adhesions and connective tissue, bring hydration and blood flow to body tissue and drain excess fluids and toxins by way of the lymphatic system. Including massage that is sensitive for various diagnosis.
Suzanne ThompsonMassage Therapy Coordinator
To schedule an appointment or to request a gift certificate, please email or call: 336-716-8304-Massage Line 336-713-3076-Lynn ButnerWe have 2 stationary locations: Medical Plaza - Miller (formerly CompRehab Plaza) – Fitness Center131 Miller StreetWinston-Salem, NC 27157Sticht Center – 2nd FloorMedical Center BoulevardWinston-Salem, NC 27157And 2 off-site locations:
Sports Medicine - Stratford1901 Mooney StreetWinston-Salem, NC 27103Arbor AcresAsbury Place1240 Arbor AcresWinston-Salem, NC 27127To schedule an appointment at any of the above locations, please call the Massage Line, 336-716-8304 or contact Lynn Butner, 336-713-3076 or firstname.lastname@example.com Programs within Recreation Therapy.
Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.


text: Columbia Chrysler located at 5840 Minoru Boulevard in RICHMOND, BC, is well stocked with vehicles to meet your every need! If you don't see a particular vehicle, try our Car Finder and let us know what you need so we will gladly inform you when a matching vehicle arrives. Call us at 604-273-8018 for more information.


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You can read Human Kinetics e-books on desktop, laptop, and various mobile devices, as long as you have authorized the device or e-reader app to read e-books protected by Adobe's digital rights management (DRM).
Formats available: PDF, ePUB
A textbook for undergraduate courses on motor development. Also a
reference for researchers in motor behavior and motor development as
well as practitioners in physical and occupational therapy, physical
education, and rehabilitation.
Kathleen M. Haywood, PhD, is a professor and associate dean for
academic programs at the University of Missouri at St. Louis, where she
has researched life span motor development and taught courses in motor
behavior and development, sport psychology, and biomechanics. She earned
her PhD in motor behavior from the University of Illinois at
Urbana-Champaign in 1976.
Haywood is a fellow of the National Academy of Kinesiology and the
Research Consortium of the Society for Health and Physical Education
(SHAPE). She is also a recipient of SHAPE's Mabel Lee Award. Haywood has
served as president of the North American Society for the Psychology of
Sport and Physical Activity and as chairperson of the Motor Development
Academy of SHAPE.
Haywood is also the coauthor of four editions of Archery: Steps to
Success and of Teaching Archery: Steps to Success, published
by Human Kinetics. She resides in Saint Charles, Missouri, and in her
free time enjoys fitness training, tennis, and dog training.
Nancy Getchell, PhD, is an associate professor at the University
of Delaware in Newark. For nearly 30 years, Getchell has investigated
developmental motor control and coordination in children with and
without disabilities. She teaches courses in motor development, motor
control and learning, research methods, and women in sport.
Getchell is a professional member of the North American Society for the
Psychology of Sport and Physical Activity, the International Society of
Motor Control, and the International Society for Behavioral Nutrition
and Physical Activity. She is a research fellow for the Research
Consortium of the American Alliance for Health, Physical Education,
Recreation and Dance (AAHPERD). From 2005 to 2009, Getchell served as
editor for the Growth and Motor Development section of Research
Quarterly for Exercise and Sport. Getchell has also served as the
chairperson of the AAHPERD Motor Development and Learning Academy.
Getchell obtained her PhD from the University of Wisconsin at Madison in
1996 in kinesiology with a specialization in motor development. In 2001,
Getchell was the recipient of the Lolas E. Halverson Young Investigators
Award in motor development.
Getchell resides in Wilmington, Delaware, where she enjoys hiking,
geocaching, and bicycling.
"This is a welcome update and retains the quality that characterized
previous editions. It contains updated peer-reviewed evidence, but,
perhaps equally important, includes contributions from the
well-respected authors."
—Doody's Book Review
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The Old Stone House and Musical Ecologies Present: Zach Layton
Thursday, April 11, 2013
8:00 p.m.–9:00 p.m.
Please note: This event has already taken place. Please use the Search options on the right to find upcoming events.
Join us for a conversation and performance by Brooklyn-based guitarist, composer, curator, improviser, teacher and video artist Zach Layton, hosted by composer Dan Joseph.
Layton's work investigates unconscious autonomic musical impulses via improvisation and indeterminacy. Using an EEG which can monitor brainwave signal in realtime, he is able to sonify and visualize this stream of unconscious data. His music involves a combination of digital and analog processes, field recordings and electric guitar played in non-standard tunings.
Suggested donation at the door.
The Old Stone House is located at 336 3rd Street between 4th and 5th Avenues.
Suggested Donation
Contact Number
(718) 768-3195


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'Stangs host Tigers; Lady 'Stangs start playoffs
Spring fever is a common thing for many people in late April when the weather begins to stay warmer.Fans of the Sweetwater High School baseball and softball teams, though, have another name for it: playoff fever.Since softball was adopted as a UIL sport, this is the first time for the Lady Mustangs (20-13) and the Mustangs (15-12) to both advance to the playoffs. In fact, in that 17-year span prior to 2013, each of the programs had gone to the playoffs just three times. But that's all changed.The baseball team ends the regular season by hosting Snyder at 7 p.m. today, and will clinch the district championship with a win, plus a Big Spring win today over Wylie, which is tied with Sweetwater for the district lead at 7-2. If Sweetwater and Wylie finish in a first-place tie, the Mustangs will be con-sidered the No. 2 team due to the fact that the Bull-dogs swept their two head-to-head meetings. The dis-trict champion will receive a first-round bye.The Sweetwater softball team, meanwhile, starts the playoffs by going to the Lubbock area on Saturday to face Pecos in a Class 3A bi-district matchup that will start at 7 p.m. The game will be at Wolfforth Frenship High School. The Lady Mustangs were the District 4-3A runnerup this season at 6-4, while Pecos was the third-place team in District 3-3A. Saturday's winner will face Pampa in the area playoffs.Sweetwater has lost two straight since clinching its playoff berth with a win over Big Spring, including a loss to Wylie in its season finale this past Saturday. According to head coach Tony Heredia, the team has concentrated this week on its hitting. "We've been leaving too many runners on base," he said. "We're not putting (the ball) down on the ground. "We know we could be bi-district champions or go home. I don't think we are doubting ourselves. We were in every game in district play this year but one. We just haven't had the big hit the last two games. We want to do that Saturday."


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Be responsive to customers and lower costs. That's smart.
Intelligently automate the way you greet customers, without the cost and complexity of a traditional Interactive Voice Response (IVR) implementation.
Understand what your callers need—before they reach a live agent.
OpenScape Contact Center Call Director offers a fully integrated IVR system, providing an automated, intelligent 'front-end" for incoming voice contacts. Call Director provides greetings, menus and announcements to your customers before connecting them to a live agent, while allowing callers to provide valuable information that ensures their calls are routed according to who they are, and what they need.
- Integrated IVR solution for OpenScape Contact Center Agile and Enterprise
- Auto-attendant with navigation menu prompts
- Estimated wait time or position in queue announcements
- Caller input digit collection and response for basic self-service
- Up to 200 simultaneous sessions per server, 1000 sessions per system
More intelligent routing decisions.
The ability to read from and write to external databases simplifies customer "data-directed" routing. That means routing priority and wait times can be optimized according to the customer's value to you.
Call Director can also provide basic transactional or self-service applications that previously may have required a more complex and expensive external IVR integration.
It's customer service, made simple.
Managers can design call flows easily with a convenient drag-and-drop interface, to integrate the components into routing and queue processing, including:
- Auto-attendant with navigation menu prompts
- Caller input digit collection
- Announcements and greetings
- Intelligent messages such as estimated waiting time or position in queue
- Dynamic, multi-format "numbers-to-speech" playback
Success Story | AZ Damiaan Hospital
See how our Call Director IVR lowered average wait time to 20 seconds and average contact handling time to 57 seconds for AZ Damiaan's patients.
Find out how Coca-Cola implemented an innovative voice portal solution for automatic assistance for its customers that makes intelligent use of both DTMF and Speech.
Success Story | Orlando Utilities Commission
Learn how our speech-enabled IVR increased OUC's completion rate by 11%, added Spanish speaking customers, and processed 14,000 calls, 300 e-checks, 400 credit card payments, and 200 stop service calls in the first weekend alone.
What is IVR?
Interactive voice response (IVR) is an automated customer engagement technology that interacts with callers, gathers and shares information and routes calls to the appropriate recipient.
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Contrary to what the AMA or motorcycling gentry may believe, not all motorcycles are created equal. Due to a combination of marketing, riding styles, and environment, the following five types of motorcycles are the country's most dangerous.
While the NHTSA doesn't track motorcycle accidents and crashes based on the type of motorcycle being ridden (among other things), the cultural factors that surround motorcycle injuries and fatalities paint a stark picture, which we've shared with you here.