text:
Drug information provided by: Micromedex
Lurasidone is used to treat symptoms of psychotic (mental) disorders, such as schizophrenia. This medicine should not be used to treat behavioral problems in elderly patients who have dementia.
This medicine is available only with your doctor's prescription.
This product is available in the following dosage forms:
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of lurasidone in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lurasidone in the elderly. However, this medicine should not be used for behavioral problems in older adults with dementia.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Take this medicine only as directed by your doctor even if you feel well. Do not take more of this medicine and do not take it more often than your doctor ordered. This medicine works best if there is a constant amount in the blood. To keep blood levels constant, take this medicine at the same time each day and do not miss any doses.
You must take this medicine with food (containing at least 350 calories).
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.
Lurasidone should not be used with ketoconazole (Nizoral®) or rifampin (Rifadin®, Rimactane®). Make sure your doctor knows what medications you are taking or if you start a new medicine.
Stop taking this medicine and check with your doctor right away if you have any of the following symptoms while using this medicine: convulsions (seizures), difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).
This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you have lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs while you are using this medicine.
This medicine may increase the amount of sugar in your blood. Check with your doctor right away if you have increased thirst or increased urination. If you have diabetes, you may notice a change in the results of your urine or blood sugar tests. If you have any questions, check with your doctor.
This medicine may increase your weight. Your doctor may need to check your weight on a regular basis while you are using this medicine. Talk to your doctor about ways to prevent weight gain.
Lurasidone can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor right away if you think you are getting an infection, or if you have a fever or chills, a cough or hoarseness, lower back or side pain, or painful or difficult urination.
Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your doctor.
This medicine may cause some people to become drowsy or dizzy, or to have trouble with thinking or controlling body movements. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that requires you to be alert, well-coordinated, or able to think well.
Avoid activities involving high temperature or humidity. This medicine may reduce your body's ability to adjust to the heat.
Lurasidone may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies. If you or your caregiver notice any of these side effects, tell your doctor right away.
This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicines including other narcotics, medicine for seizures (e.g., barbiturates), muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.
Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Portions of this document last updated: March 01, 2017
Original article: http://www.mayoclinic.org/drugs-supplements/lurasidone-oral-route/side-effects/drg-20074588
Copyright © 2018 Truven Health Analytics Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.
Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.
Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised.
A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.


text:
30 U.S. Code § 1002 - Lands subject to geothermal leasing
Subject to the provisions of section 1014 of this title, the Secretary of the Interior may issue leases for the development and utilization of geothermal resources (1) in lands administered by him, including public, withdrawn, and acquired lands, (2) in any national forest or other lands administered by the Department of Agriculture through the Forest Service, including public, withdrawn, and acquired lands, and (3) in lands which have been conveyed by the United States subject to a reservation to the United States of the geothermal resources therein.
2005—Pub. L. 109–58 inserted section catchline and substituted "geothermal resources" for "geothermal steam and associated geothermal resources" in two places in text.
LII has no control over and does not endorse any external Internet site that contains links to or references LII.

subset: commoncrawl


text:
COLLEGE STATION – Here's an honor I just don't picture Dennis Franchione and Mike Sherman receiving: Second-year Texas A&M coach Kevin Sumlin will be named an "honorary World Heavyweight Champion" by WWE on Sunday at 5 p.m. in Reed Arena.
Sumlin will receive a championship belt – yet another talking point for visitors for the fiery coach who's obsessed with recruiting.
In gleefully pleading ignorance to all things WWE, I'll turn it over to AggieAthletics.com from here.


text:
Tag: dogs dogs dogs
When dogs descend on Mayberry
Ace's herniated disc — steadily improving, it seems — has slowed our wandering ways, leading us to limit out travels for at least another week. So far, during our stay in North Carolina, we've mostly stuck around the mansion grounds, taking it easy.
But that doesn't mean we still can't go to Mayberry, one way or another.
There are those who will tell you there is no real Mayberry in North Carolina. They're the same ones who will tell you there is no Santa. In truth, in North Carolina, Mayberry is never more than 30 minutes away from wherever you are. You just head down that country road, away from the city, past the suburbs, and stop in the first town big enough to have gas pumps and a barber shop. If you're greeted with a smile, and it appears genuine, you're in Mayberry.
Of all the smallish towns in North Carolina, Mount Airy is the one that makes the most of its link to Mayberry, and — it being just up the road — we'll be going there once Ace is up for it.
For now though, we get there via the couch, with a remote control as our steering wheel. Usually, if you keep flipping, you can find it and, for 30 minutes, go back to a time and place where gigabytes didn't exist, the pace was slow, things were black and white, and life had just the right amount of complications — enough to keep it interesting, but not so many as to overwhelm your hard drive.
That's what I liked about Mayberry: Every problem could, in less than 30 minutes, be resolved with some calm and unrushed reasoning — even what to do with a pesky pack of stray dogs.
PART ONE: In which Otis gets his breakfast and Opie finds a dog …
PART TWO: In which Barney takes the dogs — 11 of them now — to a happy place …
PART THREE: In which the strays save the day …
Posted by John Woestendiek March 26th, 2011 under Muttsblog.
Tags: ace, andy griffith, andy griffith show, barney, black and white, dog's country, dogs, dogs dogs dogs, dogscountry, giraffes, investigator, lightning, mayberry, mount airy, mt. airy, north carolina, opie, otis, rescue, shelter, simpler times, storm, stray, television, travel, travels with ace, tv
Comments: 2


text:
Henry County Histories
The following county histories are located in the microfilms area on the second floor of the library. Please ask a librarian at the microforms desk or the reference desk if you need assistance with these materials.
F-2380 (vol. 1, A-K)
F-2381 (vol. 2, L-Z)
Title: Henry county, Indiana, index of names of persons and of firms.
Author: U.S.--Work projects administration--Indiana.
Published: Indianapolis, 1941.
Reel 12 No. 48
Title: Biographical memoirs of Henry county, Indiana, to which is appended a comprehensive compendium of national biography ...
Published: Logansport, Ind. : B.F. Bowen, 1902.
Reel 29 No. 110
Title: Hazzard's history of Henry county, Indiana, 1822-1906. Volume 2.
Author: Hazzard, George, 1845-.
Published: New Castle, Indiana : G. Hazzard, 1906.
Edition: Military ed.
AGLLReel 4
Reel 32 No. 119
Title: An illustrated historical atlas of Henry co[unty] Indiana.
Author: Higgins, Belden and Company, Chicago.
Published: Chicago : Higgins, Belden & Co., 1875.
Reel 56 No. 225
Title: Henry county; past and present. A brief history of the county from 1821 to 1871.
Author: Pleas, Elwood.
Published: New Castle, Ind. : Pleas Brothers, 1871.
Title: Henry county; past and present. A brief history of the county from 1821 to 1871.
Author: Pleas, Elwood.
Published: New Castle, Ind. : Pleas Brothers, 1871 [1967].
Reel 54 No. 217
Title: People's guide; a business, political and religious directory of Henry county, Indiana; together with collection of very important documents and statistics connected with our moral, political and scientific history; also a historical sketch of Henry County, with a brief history of each township.
Published: Indpls., 1874.
Title: Fall Creek township, Henry county, Indiana, in the war of the rebellion and the war with Mexico, with an appendix giving a short history of the Grand Army of the Republic, department of Indiana, George W. Radar Post no. 46, S. of V., U.S.A.
Author: Young, J. A.
Published: [New Castle, Ind: : Courier Co. Book and Job Printing Rooms, 1887].
AGLL Reel 4
Reel 59 No. 234
Title: Henry county, Indiana, topography, history, art folio including chronological chart of general, national, state and county history.
Published: n.p., 1893.
Title: History of Henry County, Indiana : together with sketches of its cities, villages and towns, educational, religious, civil, military and political history, portraits of prominent persons, and biographies of representative citizens : also a condensed history of Indiana.
Published: Knightstown, Ind. : Eastern Indiana Publishing Co., 1966.


text:
CHICAGO (AP) -- Nearly 250 physicians are calling on Illinois lawmakers to legalize the use of marijuana for patients with serious illnesses.
Three physicians spoke during a news conference today. They say marijuana can be a safer and more effective treatment than narcotics for patients with diseases such as cancer and HIV.The Illinois House is expected to vote tomorrow on a bill that would create a medical marijuana pilot program. It would allow physicians who have an existing relationship with a patient to prescribe marijuana for certain conditions. Patients would be limited to buying 2.5 ounces at a time from dispensaries regulated by the state.Julie Falco of Chicago uses marijuana to treat multiple sclerosis symptoms. Falco says she and other patients shouldn't be considered criminals for trying to ease their suffering.


text:
Browse Lessons Learned
The greatest lesson I have learned is the need to alter the role historians play in the development of K12 history teachers . . . [...] »
Being a successful history teacher also necessarily involves being an engaged teacher, and putting teachers in the role of students can have brilliant consequences when mixed with new content. [...] »
What constitutes the success of a Teaching American History (TAH) program, and what are the evaluation criteria for that success? [...] »
Passionate project directors can spell the difference between successful and so-so programs. [...] »
Get the most out of your grant; the benefits of collaboration as professional equals abound. [...] »
You've gone to the workshops. Now, how do you put what you learned into practice? [...] »
A lead historian provides continuity and consistency. [...] »
When schools partner with the history institutions in their own communities, the various stakeholders in history education are brought together. [...] »
What makes a Teaching American History (TAH) evaluation successful? [...] »
Teachers from Maine demonstrate how biographies enhance their ability to stimulate critical thinking across developmental levels. [...] »


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Last year I had the good fortune to meet Sensei Paul Yamaguchi at his home on the island of Kauai. We discussed many subjects but one has affected my training the most.
He stressed the importance of keeping the weight on the balls of the feet. Just as in Judo, the weight should not be on the heels. It is said that you should always be able to slide a piece of paper under your heels.
I already "knew" about this, but when I stopped and thought about it, I did not consistently practice it. So when I returned to Oahu, I started to concentrate on keeping the weight on the balls of my feet. The results were instant -- my feet and legs hurt, which meant I had not been distributing my weight properly before.
Since then, I have always checked my weight distribution. It seems like a small thing, but keeping the weight on the balls of the feet really makes a difference. It enables you to move faster, keep your balance, change directions, and shift your weight. It makes your movement "springier."
Try this. Put your weight on the balls of your feet and feel the muscles of your legs (especially your thighs), butt, and stomach (abdominals). Now imaging doing this all the time during Karate practice. This weight distribution starts the process of connecting your upper and lower body and is necessary for whole body movement.
I should add that the idea is not to keep the weight solely on the balls of the feet but on the toes as well. The toes grab the floor. I say that the flesh of your heels can touch the floor, but not the heel bone.
I often tell my students: keep the weight on the balls of your feet (and toes), tuck your koshi, squeeze your lats (latissimus dorsi), and keep your elbows close to your body. These are basics of the Kishaba Juku form of Shorin-Ryu. However, they are also common to other forms of Karate. It seems to me that my friends in Goju-Ryu do the same.
Charles C. Goodin
Balls of the Feet
Last year I had the good fortune to meet Sensei Paul Yamaguchi at his home on the island of Kauai. We discussed many subjects but one has affected my training the most.
Posted by Charles C. Goodin on Wednesday, March 29, 2006


text:
Table of Contents
Apply these lessons to your own training and take your running to the next level.
On the opening weekend of athletics competition at the Olympic Games in London two Saturdays ago, training partners Mo Farah and Galen Rupp, who are coached by former Boston and New York City Marathon champion Alberto Salazar as part of Nike's Oregon Project, electrified the crowd at Olympic Stadium with their historic 1-2 finish in the men's 10,000-meter final.
Farah and Rupp, a Brit and an American who have been training together for much of the past two years, kept close tabs on one another throughout the race, careful not to let the other get too far away. At one point, when the pace slowed and Rupp was getting antsy, it was Farah who tapped him on the shoulder and told him to be patient.
When the bell rang with one lap to go, Farah expectedly bolted into the lead, sprinting away over the final 400 meters with everything he had left in his legs. Not far behind him was Rupp, who found himself in fourth with 200 meters to go behind Farah and the Bekele brothers—Tariku and Kenenisa, the latter the reigning Olympic champion and world record-holder in this event. Coming off the final turn onto the home straightaway, Farah continued to lead, victory virtually assured, while Rupp found another gear, surging past the Bekele bretheren with 60 meters to go. Seconds later, Farah crossed the finish line, and, after realizing victory was his, looked back to see who else but his training partner, Rupp, raising his hands in triumph right behind him.
Meanwhile, somewhere in the stands of Olympic Stadium, Salazar was smiling. He would say afterward that he knew all along his two athletes would each medal, a goal finally realized years after it had become publicized. Since Salazar began coaching Rupp back when the 26-year-old blond haired boy with boyish looks was still in high school, he told anyone who would listen that his mission was to put an American on the medal stand. When Farah joined his training group some 18 months ago, Rupp, who had chased around the likes of Dan Browne, Adam Goucher and others when he began working with Salazar in high school, once again had someone one level above him to run down in practice on a daily basis.
Farah and Rupp crossing the finish line 1-2 on the world's biggest stage is more than just a big win for Great Britain or the United States; it's a victory for Salazar, too, who, not without criticism from other coaches, athletes, media and anyone else in the running world with an opinion, has been toying and tinkering with athletes, their training, their strides and their minds in an effort to prove that yes, in fact, runners from Kenya and Ethiopia can be beaten without the aid of performance-enhancing drugs.
Of course, while the myriad of resources Salazar and his athletes have at their disposal through their relationship with Nike can't be overlooked, here are five fundamental lessons from his Oregon Project model that runners of all ability levels can apply to their own training in order to take their racing to the next level.


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Bluray Ripper
free games downloads
C: \ Security & Privacy \ Other \ Privacy Eraser Free 4.35.2
Privacy Eraser Free 4.35.2 - Detailed Description Page
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Cybertron Software Co., Ltd. All programs by this author
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Privacy Eraser is an all-in-one privacy suite that protects your privacy by cleaning up all your Internet history and past computer activities. It supports popular web browsers such as Internet Explorer, Mozilla Firefox, Google Chrome, Safari and Opera, completely implements and exceeds the US Department of Defense and NSA clearing and sanitizing standard, once erased with it, your file data is gone forever and can not be recovered.
Privacy Eraser is an all-in-one privacy suite that protects your privacy by cleaning up all your Internet history and past computer activities. It supports popular web browsers such as Internet Explorer, Mozilla Firefox, Google Chrome, Safari and Opera.
With simply one click, Privacy Eraser can quickly erase the Internet cache, cookies, browsing history, address bar history, typed urls, autocomplete form history, saved password and index.dat files of your browser, and Windows' run history, search history, open/save history, recent documents, temporary files, recycle bin, clipboard, taskbar jump lists, dns cache, log files, memory dumps, error reporting and much more.
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What 11 golf clubs you owned are worth
Here's a look at 11 classic golf clubs or sets of clubs from the past and what they're worth today.
Find distance in your driver like DJ does
Here are 3 tips from 2013 PGA National Teacher of the Year Lou Guzzi on how you can get more distance off the tee.
100 yards to go: Strategy for success
You're in the fairway and 100 yards from the green; PGA Pro Billy Ore offers strategy for getting your ball close to the pin.
Chipping tips for all types of rough
Shave a few strokes off your score by knowing how to hit chip shots out of different types of rough.
When to use putter instead of a wedge
Learn a few tips about when to use your putter instead of a wedge around the green to help simplify getting up-and-down.
What's the right amount of club 'bounce'?
Find out what a club's 'bounce' is and how much of it you should use hitting shots out of the bunker.
Hit a flop shot like Phil Mickelson
Wanna learn how Phil Mickelson hits his flop shot? PGA Professional John Webster explains the key fundamentals.
For Your Game
Find the Perfect Course
Warm up with these beautiful course photos
PGA.com showcases some of the best golf course photos shared on social media with #PGA365
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Disabled Veteran (DV) License Plates
Disabled Veteran specialty license plates are available to eligible applicants at no fee (limit one set per applicant). To qualify for Disabled Veteran specialty license plates, you must be a Missouri resident who has served in and was honorably discharged from the United States Armed Forces.
How to Apply for Regular Disabled Veteran License Plates
To apply for Disabled Veteran license plates, you will need to submit:
- A completed and signed Application for Missouri Military Personalized License Plates, form DOR-4601, and
- A statement from the United States Department of Veteran Affairs, no more than one year old, stating your disability is service-connected. The letter must be directly from the VA, not a veteran's hospital or clinic. A letter from an attending physician at a Veteran's hospital or clinic is not acceptable documentation of a service-connected disability.
Personalized Disabled Veteran License Plates
If you prefer, your Disabled Veteran license plates can be personalized, instead of having a "stock" configuration.nEven if you choose personalized plates, there is no personalized plate fee. Simply check the appropriate box on the form, and submit up to six configuration choices on the form.
Disabled Veteran License Plates with the Wheelchair Accessibility Symbol
The Disabled Veteran license plates do not allow parking in disabled parking spots unless they display the wheelchair accessibility symbol. If you are requesting the wheelchair accessibility symbol on the license plate, you must also submit an original signed Physician's Statement for Disabled License Plates/Placard (DOR-1776) from an advanced practice registered nurse, licensed physician, chiropractor, podiatrist, physical therapist, or optometrist, stating that the disability is permanent. The physician's statement is valid for 90 days after completion by the physician.


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Stanford got hit hard by the NFL draft this month, but it could have been worse.
Of the five players who considered jumping to the pros, three made the move: All-American guard David Yankey declared his intentions Monday, while free safety Ed Reynolds and offensive tackle Cameron Fleming made it official Tuesday.
Yankey is an All-American, Fleming a three-year starter and Reynolds a first-team all-Pac-12 performer.
"A better script could not have been written for my experience at Stanford as a student-athlete," Reynolds said in a statement.
Inside linebacker A.J. Tarpley and defensive end Henry Anderson announced last week that they will return in 2014, allowing the Cardinal to avoid a mass exodus, but Stanford must replace six key members from one of the nation's best defenses.
In addition to Reynolds, Stanford loses senior linebackers Shayne Skov and Trent Murphy, nickel back Usua Amanam and ends Ben Gardner and Josh Mauro.
Mauro began the season as a reserve but started 11 games because of injuries to Gardner and Anderson.
The attrition is also significant on offense.
The Cardinal must replace tailback Tyler Gaffney, who rushed for 1,709 yards and 21 touchdowns, steady fullback Ryan Hewitt and four-fifths of its line: Yankey, Fleming, senior center Khalil Wilkes and senior right guard Kevin Danser.
The lone returning starter up front is left tackle Andrus Peat.
Two of the four likely replacements — guard Joshua Garnett and tackle Kyle Murphy — were touted recruits who gained significant experience this season playing in Stanford's so-called Jumbo formations, with additional linemen.
For more on college sports, see Jon Wilner's College Hotline at blogs.mercurynews.com/collegesports. Contact him at 408-920-5716.


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GREENVILLE, N.C. – Sophomore Julian Nelson (Irmo, S.C.) led Coker with 14 points, eight rebounds and four assists in the Cobras' 63-50 loss to Division I East Carolina University on Thursday night.
The loss, Coker's first of the season, drops the Cobras to 2-1 on the season, while East Carolina improves to 2-1 with the victory.
Junior Austin Harper (Chesnee, S.C.) added 10 points and six rebounds to the Cobra offense, while Sharod Williams (Miami, Fla.) and Avery Harris (Lancaster, S.C.) posted eight points each off the bench.
ECU's Darrius Morrow led all scorers with 25 points and eight rebounds.
The Cobras will continue their busy weekend of basketball on Friday with the start of the Zaxby's Tip-Off Clazzic at Francis Marion University. Coker will take on Chowan University in their first game of the clazzic at 6 p.m. They will then take on Morris College on Saturday in their second game, also at 6 p.m.


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Debt Settlement Companies
Debt settlement companies are for-profit companies that claim that they can eliminate consumers' debts by negotiating settlements with creditors that are a mere fraction of the consumer's outstanding debt. Many of these companies accomplish little for consumers and charge hefty fees.
Many debt settlement companies make promises that they simply cannot keep and leave consumers in worse financial state then when they began. These companies advise consumers to stop paying debts and, instead, to place money into savings account so that enough money will accumulate to allow a settlement offer to be made to any creditors.
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CANDIDATE CONSIDERATION: WCCS board reviewing replacements
COLUMBIA CITY — Whitley County Consolidated Schools will soon go about the task of selecting a new school board member.Chris Bechtold was elected in 2010 and took office in 2011. He announced his resignation, effective Aug. 5, because he will be taking a teaching position at Eagle Tech Academy. Board members are not permitted to hold teaching positions.To fill the vacancy, the school board has asked for those interested to submit their interest, in writing, to the superintendent.A decision will then be made at the Aug. 5 meeting. The board will vote in a new member, who will be in office until Dec. 31, 2014, at which point that individual will be up for re-election, according to WCCS board by-law 0142.3.To read the rest of this story, see the July 27-28 issue of The Post and Mail. Don't have a subscription? Call (260) 244-5153 or subscribe to our e-edition. For breaking news, sports updates and additional coverage, bookmark the homepage and find us on facebook and twitter.


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Student Flute with Case by Gear4music
Student Flute with Case by Gear4musicDetails
Product Ref: 3570View Full Description
Full DescriptionView Full Description
Comments from customers who bought this item:
Ideal For Beginners
This Student Flute has an offset G mechanism which is much more comfortable for most players, especially those with smaller hands. It also has a split E mechanism which means the top E note is easier to play, producing a brighter sound without affecting any other notes. Both these features are beneficial to new players producing a much more rewarding playing experience as they progress.
The closed hole design of this flute makes it a lot easier to play than open hole models. Beginners will appreciate the drawn tone holes which result in an easy action and smooth sound. The springs give a light and easy to use action that improves intonation. The standard 'C' footjoint allows the student to play all the way down to bottom C.
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If you're just starting out you might be interested in the Flute Beginner Pack by Gear4Music which includes a number of additional accessories such as music stand, care kit and CD.
- Build: 16 Hole nickel-silver flute
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Included Accessories
- Hard foam canvas case
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Gear4music - a revolution in competitively priced, high-quality musical instruments and equipment.
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Please note that this extended warranty is currently only available on products sold within the EU or EEA, and is subject to the terms and conditions as detailed on the extended warranty certificate provided.
For customers in outlying areas of the country, the price of the Extended Warranty may be marginally higher, due to the potential for higher collection and redelivery transport costs.
This enhanced warranty is in addition to the standard Gear4music and manufacturer warranty policies, and the Gear4music terms and conditions of trade. No statement or condition of sale contained within these terms affects or restricts your statutory rights as defined under the Consumer Contracts Regulation 2014.
Once the product is delivered, you have 180 days to decide that you definitely want to keep it. If you decide it is not suitable for any reason, you can return it back to us for replacement or full refund, including standard delivery charges.
All Products are new unless stated, and include a minimum of 2 years warranty.
Some items are only eligible for money back guarantee if they are returned to us unused and sealed in the original packaging, and in the case of software, unregistered. These items include:
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We are unable to accept returns of any custom made items designed to work together as a unique package, such as computer system built to a customer's personal specifications. Exceptions may only be possible with prior agreement of the vendor, and may be subject to a cancellation fee.
If you also purchase items that do not qualify for free delivery, some delivery charges may be applied to your order which will be shown in your shopping basket.


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Nananana, nanaNANA, Ney, Ney - goodbye
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Joined: 10 Jul 2006
Posts: 11274
Location: PDX
Posted: Mon Aug 07, 2006 4:41 pm
Post subject:
Campaign spokeswoman Jennifer Marks said Harris is cooperating with the investigation but is "not a target."
. They can give her a target letter any time they want.
"Worse comes to worst, my people come first, but my tribe lives on every country on earth. Ill do anything to protect them from hurt, the human race is what I serve." -
Baba Brinkman
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Joined: 10 Jul 2006
Posts: 21333
Location: under the bed
Posted: Mon Aug 07, 2006 5:51 pm
Post subject:
Some Republican leaders have warned that Harris the former Florida secretary of state who played a key role in the 2000 recount that gave George W. Bush the White House is so hated among Democrats that she could drag down the entire GOP ticket.
oh, wouldn't it be oh-so-lovely if she did? one really wonders how someone who is so obviously a political idiot got into the offices she did.
but i do remember now, hearing that she too knew old randy duke's good buddy mitch.
heh - and even after being bribed, she couldn't deliver the goods. that can't encourage her big-money contributors.
aka: neverscared!
a flux of vibrant matter
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Joined: 11 Jul 2006
Posts: 2581
Location: Alba Nuadh
Posted: Mon Aug 07, 2006 7:01 pm
Post subject:
Oh god, I see it all now, how could I be such a fool!
This is the Democrats master plan, allow the GOP to controll all three brances of government, become corrupt beyond their wildest expectations, and run unopposed in future congressional and senate races after the subpoenas come in.
And here I thought all this time they were out of ideas!
bi-chromaticism is the extraordinary belief that there exists only two options
each polar opposite to each other
where one is completely superior to the other.
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Major Tom
Joined: 09 Jul 2006
Posts: 7564
Posted: Fri Sep 15, 2006 9:24 am
Post subject:
i also read that they're considering reinstating one of the conspiracy charges against delay...
...it's a good day
Rep. Bob Ney Agrees to Plead Guilty
[i]By THE ASSOCIATED PRESS]/i]
Published: September 15, 2006
Filed at 12:52 p.m. ET
WASHINGTON (AP) -- Rep. Bob Ney agreed Friday to plead guilty to two criminal charges in the congressional corruption probe spawned by disgraced lobbyist Jack Abramoff. Papers in the case said the Ohio Republican had accepted trips worth more than $170,000.
Justice Department officials said prosecutors would recommend the 52-year-old congressman serve 27 months in prison. A formal admission of guilt would make Ney the first lawmaker to confess to crimes in a Republican-heavy scandal that erupted at the dawn of the election year.
After months of stoutly denying wrongdoing, Ney signed a formal plea agreement that outlined charges of conspiracy and making false statements by not disclosing gifts he received from Abramoff on financial disclosure forms required by Congress.
In exchange for the improper gifts, Ney offered legislation on three occasions in 2002 to benefit Abramoff's lobbying clients and helped another client win a multi-million-dollar government contract for wireless communications, court papers said.
His lawyer said Ney had begun treatment for alcohol dependency, and would likely make a formal admission of guilt in a court appearance on Oct. 13.
''People must have faith and confidence in their elected officials,'' Alice Fisher, head of the Justice Department's criminal division, said as the plea bargain was announced. She said Ney had ''acted in his own interests, not in the interests of his constituents.''
In a written statement, Ney said he had ''made serious mistakes and am sorry for them. I am very sorry for the pain I have caused to my family, my constituents and my colleagues.'' The statement did not say whether he intended to serve out the remainder of his term.
Documents released by the Justice Department indicated Ney had signed the plea agreement on Wednesday, and it was filed with the court on Friday.
As recently as early summer, Ney had insisted he would seek a seventh term in his sprawling congressional district in eastern Ohio. He dropped his plans last month at the prodding of party leaders who feared the loss of his seat in the fall elections.
The first charge accuses Ney of conspiring to commit ''honest services'' fraud, a combination of mail and wire fraud often used in public corruption cases. The second count charges Ney with not revealing his gifts from Abramoff on financial disclosure forms.
Ney acknowledged accepting all-expense-paid and reduced-price trips to play golf in Scotland in August 2002, to gamble and vacation in New Orleans in May 2003 and to vacation in New York in August 2003. The total cost of all the trips exceeded $170,000, prosecutors said. Ney also admitted accepting meals and sports and concert tickets for himself and his staff.
In his statement, Ney apologized for his actions and said he recently realized ''a dependence on alcohol has been a problem for me.''
''I am not making any excuses, and I take full responsibility for my actions. Over the years, I have worked to help others, but now I am the one that needs help,'' Ney's statement said. ''I am seeking professional help for this problem. I am hopeful that with counseling, time and the support of my family and friends, I will be able to deal with my dependency.''
The 52-year-old congressman did not participate in any of the 10 roll call votes in the House on Thursday, an indication that he was away from the Capitol.
Republican voters in Ney's district selected a replacement candidate Thursday as word of the legal developments surfaced. State Sen. Joy Padgett, backed by party leaders, won easily and will face Democrat Zack Space in the fall.
Ney consistently denied any wrongdoing, even after his former chief of staff pleaded guilty in May. The aide, Neil Volz, confessed to conspiring to corrupt the congressman and others with trips and other aid. Volz became a business partner of Abramoff after leaving the congressional payroll.
Ney had a unique power perch in the House when the year dawned, as chairman of the committee with jurisdiction over the internal workings of the 435-member House. Speaker Dennis Hastert pressured Ney into surrendering his committee chairmanship earlier this year as concern rippled through the GOP ranks about the Abramoff scandal.
Any guilty plea almost certainly would renew Democratic charges of a Republican ''culture of corruption'' in the House.
While Ney becomes the first member of Congress to plead guilty in the probe, a second lawmaker, Rep. William Jefferson, D-La., is at the center of a separate investigation involving alleged bribery. He has not been charged and denies all wrongdoing.
In addition to Abramoff and Volz, the scandal has produced guilty pleas by two former congressional aides to former House Majority Leader Tom DeLay. DeLay resigned from Congress earlier in the year. He has not been charged in the federal investigation, but is under indictment on state charges in Texas in a different case. He has denied all wrongdoing.
Prosecutors also won a conviction in the Abramoff case against former White House official David Safavian, formerly the Bush administration's top procurement official.
When Volz pleaded guilty in May, he listed 16 actions he said his old boss had taken on behalf of Abramoff's clients from January 2000 through April 2004. During that period, Abramoff and his lobbying team showered Ney with campaign donations, trips, meals at Abramoff's restaurant and tickets to sporting events and concerts.
In 2000, Ney read remarks into the Congressional Record helpful to Abramoff, who was trying to acquire a Florida casino cruise-ship company.
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Joined: 10 Jul 2006
Posts: 21333
Location: under the bed
Posted: Fri Sep 15, 2006 10:17 am
Post subject:
_thought_ i heard something about that this morning.
shoulda guessed - as soon as they start insisting that they are going to stay in office, it's a sign they're about to be gone.
aka: neverscared!
a flux of vibrant matter
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Joined: 09 Jul 2006
Posts: 633
Location: Marshall, Wisconsin
Posted: Fri Sep 15, 2006 10:49 am
Post subject:
Thank god Ney is going to eat it. Now the democrats have more fuel for their corrupt republican fires - elections only 7 weeks away! We just might get this congress back. Here's hoping.
mouse wrote:
shoulda guessed - as soon as they start insisting that they are going to stay in office, it's a sign they're about to be gone.
Intersting theory - can we hope that mean Lieberman is history too?
(edit - fix quote syntax)
Wow. Tatsuya is god. Or the dragon...
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Joined: 10 Jul 2006
Posts: 21333
Location: under the bed
Posted: Fri Sep 15, 2006 11:08 am
Post subject:
well, he's running as an independent, in a place that already has a republican candidate, and where his own party has rejected him rather forcefully. doesn't leave a lot of votes for him to get. yeah, afraid old joe is history.
aka: neverscared!
a flux of vibrant matter
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Joined: 10 Jul 2006
Posts: 1357
Posted: Fri Sep 15, 2006 3:57 pm
Post subject: u c tey eat their young
can we hope that mean Lieberman is history too?
Lieberman is the republican candidate.
I'm serious. The G.O.P. abandoned their official candidate and focused on getting Lieberman elected.
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Major Tom
Joined: 09 Jul 2006
Posts: 7564
Posted: Sat Sep 16, 2006 8:12 am
Post subject:
In a statement released by his lawyers, Mr. Ney, 52, suggested that his criminal acts were related to alcoholism.
I have come to recognize that a dependence on alcohol has been a problem for me, said Mr. Ney, who friends say entered an in-patient alcohol-treatment facility this week. I am not making any excuses, and I take full responsibility for my actions.
so what we need do to break this cycle of corruption it to take ney at his word and institute mandatory testing and psychological certification for substance dependancy and abuse before letting anyone run for office...
before they run for re-election.
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Providing our community with up-to-date continuing education resources that are easy to access is a key priority of Northwest Central. Our resources are purged every year to ensure you get the most recent information on hot library topics. If you are looking for a resource that is no longer featured on the site, please contact us with a description of the item and we will do our best to locate it and deliver it to you.
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Survival Spanish for Library Staff – Survival Spanish for Library Staff was an all-day workshop Infopeople developed to provide library staff with basic skills for communicating with Spanish-speaking patrons. Now the essential words and phrases taught in the workshop have been integrated into easy to digest MP3 files that are structured so that you can practice at your own pace, whenever you want, for as long as you want! These tracks are designed for individual use, but are suitable for group practice, too!
CLIP – The Cooperative Library Instruction Project (CLIP) was a partnership between Chemeketa Community College, Lane Community College, Oregon State University, Western Oregon University and Willamette University whose mission was to design and develop sharable, web-based tutorials to assist in library instruction and information literacy.
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Natural Green Living Ideas
New Year's Eve Recycled Bottle Noise Maker
Christmas Crackers Out of Toilet Paper Rolls Tutorial
Step1: Compose a personalized Holiday message on a joyful slip of paper.
Step2: It's great to add a little gifts inside the christmas cracker. Basically insert the presents into a toilet paper roll.
Step3: This piece has to be extensive sufficient to cover the paper roll.
Step4: Measure the lengths and cut the ribbon, Tie these around the paper at each end of the roll. Knot all of these into spot and tie in a bow.
Step5: Beautify each cracker. Put in a dash of glitters, or perhaps a little pictures that you have cut from aged Xmas cards.
Step6: Place every christmas cracker up for grabs on the table for opening during a Christmas dinner.
Another Recycled Christmas Decor part4
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Pull out recycling bins
White sanitary ware by Roca
Full height stylish Porcelanosa tiling around the bath plus half height to walls with appliances
Chrome towel rail
Shaver socket
Recessed low energy spotlights
A contemporary finish of white painted walls and ceilings
Grey satin skirting boards and door frames
In the master bedroom sliding wardrobe with a choice of door finish subject to stage of build
Low energy downlighters to the cloakroom, kitchen, bathroom and ensuite
BT and Sky+ points fitted to the living room and master bedroom – Sky+ subject to subscription
Mains operated smoke, heat and carbon detectors
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The AP had called Dan Malloy the winner of Connecticut's gubernatorial race, but pulled back the call an hour ago. Its results now just Tom Foley leading by 8,500 votes with 99% of the vote reporting.
But something does not add up: The AP and CNN both show New Haven entirely reporting, and Malloy leads 7,441 to 1,579 votes. This is not plausible.
First, about 25000 voters cast a ballot in New Haven in the 2006 gubernatorial race; three times as much.
Second, the New Haven Independent reports that Dan Malloy won New Haven by 18,000 votes (22,298 to 3,685 [Corrected]). That would add up to about 25,000 - right about where we should be given the 2006 turnout level.
Third, CNN says Dick Blumenthal has won New Haven 22,154 to 3,271. So 26,000 votes were cast in the Senate race and 9,000 in the Governor's race? More than implausible. The New Haven Independent's numbers are most probably right.
This means that the AP's supposedly complete New Haven count is probably underestimating Malloy's lead by about 12,000 votes (corrected), which puts him in the lead statewide. With 40% of the vote in Democratic Bridgeport still to be counted, that makes Malloy a favorite to win.
Tom Foley is now moving ahead with his own claims to victory based on the AP's latest count, so this error has the potential of creating a lot of chaos - not to mention impact the tone of litigation going forward. If anyone notices a glaring problem in my argument or something obvious I am missing, please let me know and I will gladly retract!


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Owners of Roku media streamers can finally breath a sigh of relief, as one of the most-requested applications has finally arrived on the service. Spotify is finally on Roku... Woohoo!
Like with many of the music-streaming service's apps on set-top-boxes and home cinema gear, including Virgin Media's TiVo box, Sonos and Onkyo's latter-day range of receivers, you will need to have a Spotify Premium account to access tracks through a Roku device.
However, the Spotify Channel is fully featured and, while presented in a clean but basic fashion, gives you access to all of the millions of songs on the platform through intuitive menu systems.
It is currently available for all Roku 2 players and the Roku Streaming Stick. It will also be coming soon for Roku HD and Roku LT players.
If you don't already have a Spotify subscription, you can sign up for a completely free 30-day trial to the Premium service. After that, it costs £9.99 a month.
Another channel to start on Roku players is Vevo, the music video service.
Also read: Roku 2 XS review


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Call 866-683-4772to Research, evaluate and compare your senior housing options. It's easy and free.
Click Here to Request Quotes from Jamaica, IowaSenior Living Communities - Free Service, No Obligation
The Lakeside Village
2067 Highway 4, Panora, IA 50216
Distance: 9.8 mi
Map It
The Lakeside Village is a 64-unit senior housing community located on beautiful Lake Panorama near Panora, Iowa. Many room styles are available. There are small, assisted living efficiency apartments, and spacious two-bedroom, two-bath independent living apartments, with a wide variety of sizes and configurations between these two options.
Housing Type: Independent Living, Assisted Living


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Rita Food & Drink Co., Ltd. was incorporated in 2004 as a 100% Foreign owned Company and specializes in
the production of Beverage such as Energy Drink, Milk, Aloe vera Juice, Fruit juice, Soft Drink, Coffee, Beer,
Tea Drink, Basil seed with juice, Chia seed drink, Coconut water, drink water, Carbonated drink.....
290ml Basil Seed Drink With Mix Fruit
200 Twenty-Foot Container per Month Canned bottle production base---10000 tons/month PET bottle production base---10000 tons per month QC LAB--20 professional QC team
All Natural from Vietnam. We process juice fruits water from 100% Fresh water so it good for your health and more natural than.
We can supply Orange water with very competiitve price and based on exclusive agent if the order is reaonsoble large.
We provide OEM and private label service
No artificial flavors,no colors,no preservatives,more secure,more healthy
Flavors: fruit,peach,grape,orange,mango,watermelon,green apple,blueberry,strawberry We provide OEM and private label service.
With our 6 years of experience, We can meet your needs in : Providing 100% natural and healthy Aloe Vera Juice, Beer & Wine, Carbonated Drinks, Cereal Milk, Coconut water, Coffee Drinks, Dried Fruit & Jelly, Drinking Water, Energy Drinks Series, Fruit Drinks, Milk, Non Alcohol Beverage, Soft Drinks, Tea-Honey and Fruit, Tetra Pak Products.
Developing just the right taste to your market and customers. Quality proof product control. Flexible production capacity with short lead time.
Competitive price vs product value. Canned bottle production base---10000 tons/month PET bottle production base---10000 tons per month QC LAB--20 professional QC team


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Once we saw the unveiling of the Ducati Monster 1200 at EICMA last year, we knew it was only a matter of time before Bologna wedged its new 821cc liquid-cooled motor into a mid-size Monster machine.
That feeling was fueled further by spy photos the 821cc Monster making their way onto the internet, and now we have confirmation of the mid-sized Monster, as Borgo Panigale has officially launched its Ducati Monster 821.
Borrowing the 821cc Testastretta 11° engine (112hp and 65.9 lbs•ft) found on the newly revised Ducati Hypermotard, and its cousin the Ducati Hyperstrada, the Monster 821 continues Ducati's trend to repurpose powerplants for multiple product families.
The Ducati Monster 821 also continues Bologna's new trend of building its lower-spec midrange motorcycles with double-sided swingarms, to help further stratify and differentiate its models.


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What better way to head off to Comic-Con than with a little traveling music? Well, I'm hitting the road to San Diego, so, from Glove and Boots comes Wolverine – The Musical!, with a Hugh Jackman puppet singing about being Wolverine, plus a brief — very brief — visit from Broadway Spider-Man and others you will know. It's Snikt-abulous!
You don't have to be a show tunes person to love this….
HT: The Mary Sue


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Posted 7 years ago
(91 items)
This little bottle was sold by the Le Blume Import Company of New York. They were involved in many trademark lawsuits because they sold perfumes and other products that were trademarked by other companies. This bottle is for Narcisse Noir which was made my Caron. They call this a "gray market" or "parallel market" product. I think it's just too cool, so I thought I'd share! Thanks! :)


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WKUID and PIN
Your WKUID (800#) is your main identification number at WKU and is printed and encoded on your WKUID card. All employees are issued a WKUID upon hire and students are issued a WKUID upon application to the University. You need to memorize your WKUID and your PIN.
WKUID and PIN Links
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download quicktime.


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Fludarabine Phosphate, Radiation Therapy, and Rituximab in Treating Patients Who Are Undergoing Donor Stem Cell Transplant Followed by Rituximab for High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00104858
Recruitment Status : Active, not recruiting
First Posted : March 4, 2005
Last Update Posted : March 27, 2018
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Chronic Lymphocytic Leukemia Prolymphocytic Leukemia Recurrent Small Lymphocytic Lymphoma Refractory Chronic Lymphocytic Leukemia Stage III Chronic Lymphocytic Leukemia Stage III Small Lymphocytic Lymphoma Stage IV Chronic Lymphocytic Leukemia Stage IV Small Lymphocytic Lymphoma T-Cell Large Granular Lymphocyte Leukemia
|Procedure: Allogeneic Hematopoietic Stem Cell Transplantation Drug: Cyclosporine Drug: Fludarabine Phosphate Other: Laboratory Biomarker Analysis Drug: Mycophenolate Mofetil Procedure: Peripheral Blood Stem Cell Transplantation Other: Pharmacological Study Biological: Rituximab Radiation: Total-Body Irradiation
|Phase 2
Show Detailed Description
|Study Type :
|Interventional (Clinical Trial)
|Estimated Enrollment :
|94 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Nonmyeloablative Conditioning With Pre- and Post-Transplant Rituximab Followed by Related or Unrelated Donor Hematopoietic Cell Transplantation for Patients With Advanced Chronic Lymphocytic Leukemia: A Multi-Center Trial
|Actual Study Start Date :
|December 2004
|Estimated Primary Completion Date :
|December 2018
Experimental: Treatment (chemotherapy and rituximab followed by HCT)
Patients receive a conditioning regimen comprising fludarabine IV on days -4 to -2 and rituximab IV on days -3, 10, 24, and 38.
Patients undergo single fraction low-dose TBI on day 0. After completion of TBI, patients undergo allogeneic hematopoietic stem cell transplantation on day 0. Patients then receive rituximab IV on days 10, 24, and 38.
Patients receive an immunosuppressive regimen comprising cyclosporine PO BID on days -3 to 56 followed by a taper to day 180 (related recipients) or on days -3 to 100 followed by a taper to day 180 (unrelated recipients). Patients also receive mycophenolate mofetil PO BID on days 0-27 (related recipients) or TID on days 0-40 followed by a taper to day 96 (unrelated recipients).
Procedure: Allogeneic Hematopoietic Stem Cell Transplantation
Undergo HSCT
Other Names:
Drug: Cyclosporine
Given PO
Other Names:
Drug: Fludarabine Phosphate
Given IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Mycophenolate Mofetil
Given PO
Other Names:
Procedure: Peripheral Blood Stem Cell Transplantation
Undergo HSCT
Other Names:
Other: Pharmacological Study
Correlative studies
Biological: Rituximab
Given IV
Other Names:
Radiation: Total-Body Irradiation
Undergo TBI
Other Names:
- Survival [ Time Frame: At 18 months ]
- Comparison of survival, serious adverse events, and B-cell and T-cell immune reconstitution with historical data [ Time Frame: At 18 months ]
- Donor and host polymorphisms of the FCgammaRIIIa receptor and CD32 and their impact on disease response and relapse [ Time Frame: Day 84 ]
- Graft-versus-leukemia analysis by mechanism of disease resistance in relapsed or non-responding patients and isolation of donor cytotoxic T lymphocytes specific for host minor histocompatibility antigens [ Time Frame: Day 84 ]
- Incidence of grade II-III and III-IV acute GVHD and chronic GVHD [ Time Frame: Up to 1 year ]
- Incidence of regimen-related toxicity and infections [ Time Frame: Within the first 100 days ]Reported using the adapted National Cancer Institute Common Toxicity Criteria.
- Incidence of treatment-related mortality [ Time Frame: Up to 1 year ]
- Pharmacokinetics of rituximab [ Time Frame: Days 60, 84, 180, and 1 year ]
- Proportion of patients achieving complete response and partial response (overall response rate) [ Time Frame: Up to 1 year ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients with a diagnosis of CLL (or SLL) or diagnosis of CLL that progresses to prolymphocytic leukemia (PLL)
Patients with B-Cell CLL or PLL who:
- Failed to meet National Cancer Institute (NCI) Working Group criteria 2 for complete or partial response after 2 cycles of therapy with regimen containing fludarabine (or another nucleoside analog, e.g. cladribine [2-CDA], pentostatin) or with disease relapse within 12 months after completing therapy with a fludarabine (or another nucleoside analog) containing regimen
- Failed FCR or pentostatin/cyclophosphamide/rituximab (PCR) combination chemotherapy at any time point
- Patients with novo or acquired "17p deletion" cytogenetic abnormality; patients should have received induction treatment but could be transplanted in 1st CR
- Patients who have suitable human leukocyte antigen (HLA)-matched related or unrelated donors willing to receive filgrastim (G-CSF), undergo leukapheresis to collect peripheral blood mononuclear cell (PBMC), and to donate stem cells
RELATED DONORS: When more than one potential donor exists, priority should be given to donors based on HLA identity > cytomegalovirus (CMV) seronegativity > ABO compatibility > sex matching
- Donor who is HLA phenotypically or genotypically identical at the allele level at HLA-A, -B, -C, -DRB1, and -DQB1
- Must consent to G-CSF administration and leukapheresis;
- Must have adequate veins for leukapheresis or agree to placement of central venous catheter (femoral, subclavian);
- Only G-CSF mobilized PBMC only will be permitted as a hematopoietic stem cell (HSC) source on this protocol
- Fred Hutchinson Cancer Research Center (FHCRC) matching allowed will be Grades 1.0 to 2.1; Unrelated donors who are prospectively:
- Matched for HLA-A, B, C, DRB1 and DQB1 by high resolution typing
- Only a single allele disparity will be allowed for HLA-A, B, or C as defined by high resolution typing
- UNRELATED DONORS: Donors are excluded when preexisting immunoreactivity is identified that would jeopardize donor hematopoietic cell engraftment; this determination is based on the standard practice of the individual institution; recommended procedure for patients with 10 of 10 HLA allele level (phenotypic) match is to obtain a panel reactive antibody screens to class I and II antigens for all patients before HCT; if the PRA shows > 10% activity, then flow cytometric or B and T cell cytotoxic cross matches should be obtained; the donor should be excluded if any of the cytotoxic cross match assays are positive; for those patients with an HLA Class I allele mismatch, flow cytometric or B and T cell cytotoxic cross matches should be obtained regardless of the PRA results; a positive anti-donor cytotoxic crossmatch is an absolute donor exclusion
- UNRELATED DONORS: Patient and donor pairs homozygous at a mismatched allele in the graft rejection vector are considered a two-allele mismatch, i.e., the patient is A*0101 and the donor is A*0102, and this type of mismatch is not allowed
- UNRELATED DONORS: Only G-CSF mobilized PBMC will be permitted as a HSC source on this protocol
Exclusion Criteria:
- Infection with human immunodeficiency virus (HIV)
- Active diagnosis of central nervous system (CNS) involvement with CLL
- Patients unwilling to use contraceptive techniques before and for 12 months after HCT
- Pregnant women or females who are breastfeeding
- The addition of cytotoxic agents for 'cytoreduction' with the exception of tyrosine kinase inhibitors (such as imatinib mesylate), cytokine therapy, hydroxyurea, low dose cytarabine, chlorambucil, or rituxan will not be allowed within three weeks of the initiation of conditioning
- Active bacterial or fungal infections unresponsive to medical therapy
- Performance status: Karnofsky score < 60 for adult patients
- Cardiac ejection fraction < 40%; ejection fraction is required if age > 50 years or there is a history of prior transplant, anthracycline exposure or history of cardiac disease; and poorly controlled hypertension despite multiple antihypertensives
- Diffusing capacity of the lung for carbon monoxide (DLCO) < 40%, total lung capacity (TLC) < 40%, forced expiratory volume in 1 second (FEV1) < 40% and/or requiring continuous supplementary oxygen, or severe deficits in pulmonary function testing as defined by pulmonary consultant service; and the FHCRC principal investigator (PI) of the study must approve of enrollment of all patients with pulmonary nodules
- Patients with clinical or laboratory evidence of liver disease would be evaluated for the cause of liver disease, its clinical severity in terms of liver function, and the degree of portal hypertension; patients will be excluded if they are found to have fulminant liver failure, cirrhosis of the liver with evidence of portal hypertension, hepatic damage with bridging fibrosis, alcoholic hepatitis, esophageal varices, a history of bleeding esophageal varices or hepatic encephalopathy, uncorrectable hepatic synthetic dysfunction evidenced by prolongation of the prothrombin time, ascites related to portal hypertension, bacterial or fungal liver abscess, biliary obstruction, chronic viral hepatitis with total serum bilirubin > 3 mg/dl, or symptomatic biliary disease
- Patients with active non-hematologic malignancies (except non-melanoma skin cancers); this exclusion does not apply to patients with non-hematologic malignancies that do not require therapy
- Patients with a history of non-hematologic malignancies (except non-melanoma skin cancers) currently in a complete remission, who are less than 5 years from the time of complete remission, and have a > 20% risk of disease recurrence; this exclusion does not apply to patients with non-hematologic malignancies that do not require therapy
- DONOR: Age < 12 years
- DONOR: Identical twin
- DONOR: Pregnancy
- DONOR: Infection with HIV
- DONOR: Inability to achieve adequate venous access
- DONOR: Known allergy to filgrastim (G-CSF)
- DONOR: Current serious systemic illness
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00104858
|United States, Minnesota
|Mayo Clinic
|Rochester, Minnesota, United States, 55905
|United States, Washington
|VA Puget Sound Health Care System
|Seattle, Washington, United States, 98101
|Fred Hutch/University of Washington Cancer Consortium
|Seattle, Washington, United States, 98109
|Rigshospitalet University Hospital
|Copenhagen, Denmark, 2100
|University of Torino
|Torino, Italy, 10126
|Principal Investigator:
|Mohamed Sorror
|Fred Hutch/University of Washington Cancer Consortium
|Responsible Party:
|Fred Hutchinson Cancer Research Center
|ClinicalTrials.gov Identifier:
|NCT00104858 History of Changes
|Other Study ID Numbers:
NCI-2009-01594 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
1840.00 ( Other Identifier: Fred Hutch/University of Washington Cancer Consortium )
P01CA018029 ( U.S. NIH Grant/Contract )
P30CA015704 ( U.S. NIH Grant/Contract )
|First Posted:
|March 4, 2005 Key Record Dates
|Last Update Posted:
|March 27, 2018
|Last Verified:
|March 2018
Additional relevant MeSH terms:
Leukemia, Lymphoid
Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Prolymphocytic
Leukemia, Large Granular Lymphocytic
Leukemia, B-Cell
Leukemia, T-Cell
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Fludarabine phosphate
Antibodies, Monoclonal
Mycophenolic Acid
Immunologic Factors
Physiological Effects of Drugs
Antineoplastic Agents
Antirheumatic Agents
Antimetabolites, Antineoplastic


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I would like to say of the three services I utilized, yours was the most professional. You do a really solid job of providing the information to all parties, your follow up with potential matches, and providing the email outlet for easy communications. Once again thanks & I will refer you to any friends or coworkers that could utilize your service. Sincerely, Kirt
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Auntie Blackbeard wrote:It wuz ye birfday, Bartie? Why didnt ye tell me? Oi wooda baked ye a big ol' scone fulla fish head stew for ye!
Be thargh anyfin' oi could do fer ye in loo ove dat?
Yer daft tart Auntie...ye were der all night...most o the toim ye were unconscious in the bilge arter ye drained the Captain's Punch bowl.


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Transformers: Age Of Extinction: The Spoiler FAQ
Did you watch Michael Bay's newest cinematic aberration this weekend and come away confused? Our patented Spoiler FAQ has the answers to every question you have about the Transformers: Age Of Extinction! (Yes, including the one about statutory rape, since Michael Bay decided to bring it up.)


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What You Should Know About Colorectal Cancer Screening
It's common knowledge that finding and treating cancer early can save your life. Many cancers grow slowly over a period of years, without presenting symptoms until it's too late. Fortunately, you can stay one step ahead by getting recommended screening tests. Screening tests are used to detect cancer in specific areas of the body before symptoms appear. If cancer is found during a screening test, prompt treatment may increase your chance of a cure and prolong your life.
Colorectal cancer encompasses the colon and rectum . They are third leading cause of cancer deaths in the United States. The chances of survival are high when diagnosed before the cancer invades adjacent tissue or spreads to another site. Screening has become very important in the battle against these types of cancer.
The thought of a colonoscopy can be unnerving, but in reality it is a short, painless procedure. However, you do have other options. There are many different colorectal screening tests to choose from.
Screening Tests:
Colorectal screening tests are designed to detect cancer or polyps . Polyps are finger-like projections that grow on the inside of the colon wall. Generally, polyps are not cancerous, but the it is believed the vast majority of colorectal cancers begin as polyps. Polyps can also be found to be precancerous. Precancerous polyps have subtle changes associated with them that increase the risk of them becoming cancerous over time.
The risk of colorectal cancer increases with age. For men with average risk, this means screening should begin at age 50 (age 45 for African Americans, American Indians/Alaska Natives). The time between tests depends on the type of test you choose to have and your underlying risk. Recommended screening tests include the following:
Fecal Occult Blood and Fecal Immunochemical Tests
The fecal occult blood test and fecal immunochemical test look for hidden blood in a sample of stool (feces) you have already passed. Blood in your feces may be the result of bleeding from a cancerous polyp in your colon or rectum, or it may be a sign of a more benign condition.
Flexible Sigmoidoscopy
For a flexible sigmoidoscopy , a thin, lighted tube with a camara on the end is inserted into the rectum and lower colon to examine their internal mucosal lining. Images can be recorded while the doctor looks for polyps and other abnormalities on a monitor. This procedure does not look at the entire length of the colon like a colonoscopy does. Polyps or other abnormal tissue can be removed during the procedure and examined under a microscope.
For a colonoscopy , a thin tube similar to a flexible sigmoidoscope is used. This time, the lighted tube goes all the way through to the end of your colon where it connects to the small intestine. Polyps or other abnormal tissue can be removed during the procedure and examined under a microscope.
Double-Contrast Barium Enema
A double-contrast barium enema involves the injection of contrast material called barium followed by air into your rectum. This makes your entire colon visible on an x-ray, allowing doctors to see abnormal growths, like polyps.
CT Colonography
CT colonography is a technique that takes computer generated x-ray images after injection of air into the colon. One disadvantage to having this test compared to a colonoscopy is if a polyp is discovered during colonoscopy it can be removed right then and there, while if one is detected with virtual colonoscopy, a follow-up colonoscopy will be necessary. Another is the amount of radiation exposure to do the test.
MR Colonography
An MR colonography uses magnetic fields to view the entire colon. Water and contrast material are used to expand and view the colon. Compared to conventional colonoscopy, MR colonongraphy is not as effective at detecting smaller polyps. Again, if polyps are detected, a follow-up colonoscopy will be necessary. There is no radiation exposure.
Screening Recommendations
The American Cancer Society suggests that starting at age 50, men and women at average risk of developing colorectal cancer should use one of the following options:
- Colonoscopy every 10 years
- Flexible sigmoidoscopy every 5 years
- CT colonography every 5 years
- Double-contrast barium enema every 5 years
- Annual fecal occult blood test (FOBT)
- Annual fecal immunochemical test (FIT)
However, people at increased risk of colorectal cancer may need to have some of these tests earlier in life and more often. Some reasons why you would be considered high risk are:
- Personal or family history of colorectal cancer or adenomatous polyps
- Personal history of chronic inflammatory bowel disease, such as ulcerative colitis or Crohn's disease
When you receive the results of your screening test, your doctor will advise you when you should have another test. Depending on the result, it may be more often than the recommended time frames outlined above.
What Tests Do You Need?
Talk to your doctor about the advantages and disadvantages of each screening test, especially if your risk for colorectal cancer is greater than average. These tests may save your life.
- Michael Woods, MD
- Reviewed: 03/2016
- Updated: 03/23/2016
Please note, not all procedures included in this resource library are available at Henry Ford Allegiance Health or performed by Henry Ford Allegiance Health physicians.
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