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Scientists Create One-Step Gene Test for Mitochondrial Diseases
Jan 29, 2013, 10:29 EST
--CHOP Researchers' New Single-Platform Tool Streamlines Diagnoses of Complicated Multisystem Disorders--
PHILADELPHIA, Jan. 29, 2013 /PRNewswire-USNewswire/ -- More powerful gene-sequencing tools have increasingly been uncovering disease secrets in DNA within the cell nucleus. Now a research team is expanding those rapid next-generation sequencing tests to analyze a separate source of DNA—within the genes inside mitochondria, cellular power plants that, when abnormal, contribute to complex, multisystem diseases.
The study team, headed by a specialist in mitochondrial medicine at The Children's Hospital of Philadelphia (CHOP), adapted next-generation sequencing to simultaneously analyze the whole exome (all the protein-coding DNA) of nuclear genes and the mitochondrial genome. "A first step in developing treatments for a disease is to understand its precise cause," said Marni J. Falk, M.D., the director and attending physician in the Mitochondrial-Genetic Disease Clinic at Children's Hospital. "We have developed a one-step, off-the-shelf tool that analyzes both nuclear and mitochondrial DNA to help evaluate the genetic cause of suspected mitochondrial disease."
Falk and colleagues describe their customized, comprehensive test, which they call the "1:1000 Mito-Plus Whole-Exome" kit, in the journal Discovery Medicine, published Dec. 26, 2012. Her co-corresponding author, biostatistician Xiaowu Gai, Ph.D., now of the Loyola University Stritch School of Medicine, collaborated on developing the test while at Children's Hospital.
While each mitochondrial disease is very rare in the population, hundreds of causes of mitochondrial diseases are known. Some originate in mutations in DNA specific to the mitochondria, tiny structures located outside the cell nucleus, while many other mitochondrial diseases are based in nuclear DNA genes that affect mitochondrial function. The role of mitochondria in human disease has been recognized only since the 1980s, based on pioneering research by Douglas C. Wallace, Ph.D., now at Children's Hospital, and a co-author of the current study.
Many mitochondrial diseases remain poorly understood. One complicating factor is heteroplasmy—a mixture of mutated and normal mitochondrial genomes within the same cells or tissues. In contrast to conventional gene sequencing, which can detect only heteroplasmic mutations that reach levels of at least 30 to 50 percent, the customized kit has the sensitivity to detect mitochondrial genome mutations present at levels as low as 8 percent. To achieve their results, the study team adapted an existing whole-exome sequencing kit from Agilent Technologies, expanding it to encompass the mitochondrial genome.
The availability of the new kit, said Falk, if used for either clinical or research purposes, may shorten the "diagnostic odyssey" experienced by many patients and families seeking the cause of debilitating and puzzling symptoms. "Many families travel from one specialist to another for years, searching for the cause of their rare disease," she says. Specific treatments are not always available, but identifying their disease cause may be the first step toward discovering treatments.
A second recent study by Falk and colleagues reviews progress in diagnosing mitochondrial disease, through their experience at a single center over a rapidly changing three-year period before whole-exome sequencing was generally available. The retrospective review in Neurotherapeutics, published Dec. 27, 2012, covers 152 child and adult patients evaluated at CHOP's Mitochondrial-Genetics Diagnostic Clinic from 2008 to 2011.
"Before 2005, very few individuals could receive definitive molecular diagnoses for mitochondrial diseases, because of limitations in both knowledge and technology," said Falk. "Since that time, the clinical ability to sequence whole mitochondrial DNA genomes has significantly improved the diagnosis of many mitochondrial disorders."
During the study period covered in the review article, the clinic at CHOP confirmed definite mitochondrial disease in 16 percent of patients and excluded primary mitochondrial disease in 9 percent. While many diagnostic challenges clearly remain, Falk says the advent of massively parallel nuclear exome sequencing is revealing increasingly more of the genes in nuclear DNA that affect mitochondrial function, and the precise genetic disorder in a given patient, even if it is novel or uncommon. She added that molecular genetics is yielding a more nuanced understanding of the cellular pathways underlying symptoms in many mitochondrial disorders. "Those pathways offer potential new targets for treating these disorders," said Falk.
Funding for both studies came from the National Institutes of Health, grant DK082446. The Discovery Medicine study also was funded through a Foerderer Award for Excellence from The Children's Hospital of Philadelphia Research Institute. Co-authors of the Discovery Medicine study included Eric A. Pierce, M.D., Ph.D., and Mark Consugar, M.S., of the Massachusetts Eye and Ear Infirmary; research and development staff from Agilent under the guidance of Emily LeProust, Ph.D.; and other collaborators from CHOP.
"Mitochondrial Disease Genetic Diagnostics: Optimized Whole-Exome Analysis for All MitoCarta Nuclear Genes and the Mitochondrial Genome," Discovery Medicine, published online Dec. 26, 2012. http://bit.ly/Vyb4lc
"Molecular Genetic Testing for Mitochondrial Disease: From One Generation to the Next," Neurotherapeutics, published online, Dec. 27, 2012.
About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking third in National Institutes of Health funding. In addition, its unique family-centered care and public service programs have brought the 516-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit http://www.chop.edu.
Contact: Dana Mortensen
The Children's Hospital of Philadelphia
Phone: (267) 426-6092
SOURCE The Children's Hospital of Philadelphia


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What to CookCommunity
Editors' Picks — Vegetarian Holiday Sides
Once again, we want to give a big thanks to all of our volunteer recipe testers for your thoughtful comments and for helping us continue to strengthen our recipe recommendations. You can read each tester's comments by clicking through to the Editors' Picks recipes — the comments are under "Amanda and Merrill's Notes" at the top. And even if the recipe you tested wasn't chosen as an EP, please feel free to leave your testing notes in the recipe's comments section. Constructive criticism is always encouraged!
Congratulations to another great batch of Editors' Picks!
- Shredded Raw Brussels Sprouts Salad with Red Peppercorns and Honey Mustard Vinaigrette
- Curried Kabocha and Kale
- Browned Crispy Spaetzle with Caramelized Shallots and Mushrooms
- Rainbow Chard Tart in a Chestnut Crust
- Ginger Shallot Broccoli
- Simple Brussels Sprouts
- Caramelized Onion Pudding
- Sweet Potato Kibbeh
- Inside-Out Sweet Potato Casserole
- Perfect brussels sprouts
- Warm Chantrelle Salad with Escarole and Pecorino Romano
- Coconut Spiced Sweet Potato Casserole

subset: commoncrawl


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The Section on Infectious Diseases is committed to excellence in its mission of research, clinical care and education. Faculty members are recognized locally, nationally, and internationally for their excellence in all three areas.
The Infectious Diseases Specialty Clinic (IDSC), an outpatient clinic of North Carolina Baptist Hospital, is the primary outpatient clinic and is one of the largest infectious diseases clinics in the state, following approximately 1,200 patients with HIV. Clinical services and research initiatives at the IDSC are being expanded through Ryan White funding to include a dental clinic and a HIV secondary prevention initiative. Faculty members, including Aimee M. Wilkin, MD, MPH; and Marina Núñez, MD, PhD; are nationally recognized for their expertise in HIV research and clinical care.
Clinic Appointment -2700Health On-Call
Everyone, age 6 months and older, is strongly encouraged to be vaccinated annually against the flu virus. Flu vaccines are your best defense against getting sick and the most effective way to control the spread of the virus.
Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.


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Win a Tassimo Suny coffee machine
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Computer services are provided at the Hillsboro Police Department while the Shute Park Library is closed for renovation. Library computer assistants will monitor the lab all hours it is open. The 13 public access computers and a printer will be available on a first come, first served basis. The lab will be located in the education room adjacent to the lobby.
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green laning in essex area ?
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Please understand that the Frontera Owners Group or any organiser of events will not be held responsible for any loss, damage, accident or injury caused by attending an event. You are responsible for your passengers and for your own safety and should carry the necessary recovery and safety equipment. You agree to follow the rules of the Highway Code, Green Lane Code and club pay and play site rules whichever applies. For greenlane events; All events should adhere to the GLASS Code of Conduct, and please note that Rights Of Way often change and if a TRO (traffic regulation order) has been put in place by the local council you should not drive the lane. If you do not agree to the above you should refrain from taking part in the event.
5 posts • Page 1 of 1
green laning in essex area ?
hi im new to the world of laning and i love it was just interested to no if anyone on here is from the essex area and does a bit of laning i would love to tag along one day
Re: green laning in essex area ?
Chuck Gregster a pm he has an off road site. Look in the the South East Meet Threads.
Comments on Betsy here please!!! viewtopic.php?f=115&t=56282
Frontera's do it better in MUD!!!
West Midlands Area Rep
Its here, the FOG Annual Meet 2014 viewforum.php?f=123
Re: green laning in essex area ?
We just ran a Essex/Herts laning day a few weeks ago. I am sure we will have another soon once it drys up a bit more, we also take a run up to Thetford thats a great place to start as it's a easy day out. As Bobby said we do also have a site in Kent which is a great day out and you can see what your Fronty can really do
Re: green laning in essex area ?
Unless Matt is behind the wheel then you get to see it stuck
i hate having Dyslexia
Re: green laning in essex area ?
great ill take a look ive been on some around stansted ive got some grabber tyres on seem to help alot
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Otolaryngology is a specialty devoted to the evaluation and treatment of ear, nose and throat (ENT) disorders as well as head and neck, hearing and communication problems. We understand how ENT conditions can affect hearing, learning, speech and sleep and impact development. Our teams provide care that takes your whole child, not just the condition, into account.
ENT conditions in children can range from recurring ear infections and enlarged tonsils, to sinus diseases or a complex craniofacial anomaly (irregular or abnormal growth of head and facial bones). Nemours ear, nose and throat doctors, called otolaryngologists, are board-certified ENT surgeons who are highly trained in the latest minimally invasive and endoscopic surgery techniques.
The most common procedures our surgeons perform include:
- tonsillectomy (removal of the tonsils)
- adenoidectomy (removal of the adenoidal tissue)
- myringotomy with tube placement (removal of fluid from the middle ear and insertion of ear tubes)
Nemours surgeons are also skilled in advanced reconstructive techniques and often work with other specialists to try to combine one or more surgeries during a single hospitalization, which helps reduce the number of times your child needs to receive anesthesia.
New JerseySpecialty Care
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Nemours Children's Specialty Care, Jacksonville
807 Children's Way
Jacksonville, FL 32207
Get Map & Directions »
For Appointments: (904) 697-3600
We offer same-day appointments when available or schedule your child to be seen within five business days.
- photo ID
- medical and pharmacy insurance cards
- preferred pharmacy name and phone number
- names and dosage of all medications, including over-the-counter medication, your child is currently taking
- guardianship and custody papers, if a legal guardian rather than a parent accompanies your child
New Patients
- Patient Registration (PDF)
Returning Patients
New Patient Forms
- Patient Registration (PDF)
Returning Patient Forms
- Release of Information (PDF)
English | Spanish
- Patient Presents Without Legal Guardian (PDF)
English | Spanish
Note: A parent or legal guardian must be with a child for a first visit.
Resources for Patients & Families
- Insurance We Accept: See accepted insurance, listed by location.
- Pay Your Bill: Use online bill pay or send by mail.
- Financial Assistance: Get help with your child's health care expenses.
- MyNemours: Access your child's medical record online.
Support Service for Overnight Stays
- Ronald McDonald House of Jacksonville: a safe, free, family-centered home away from home when your child is sick and needs to be hospitalized
When you bring your child to see an ENT specialist (ear, nose and throat doctor) at Nemours Children's Specialty Care, Jacksonville, you can expect exceptional care. Named among the "Best Doctors in America," our physicians provide comprehensive pediatric otolaryngology, head and neck, and facial plastic surgical care for children.
A Center of Excellence for Otolaryngology in the Southeast
The Nemours pediatric otolaryngology division in Jacksonville, Fla. is a recognized leader in providing state-of-the-art ENT programs, such as:
- cochlear implantation and auditory rehabilitation
- craniofacial plastic surgery, including cleft lip and cleft palate repair, rhinoplasty (nose) and otoplasty (ear)
- rhinology and sinus disease center
- balance and vestibular disorders lab
- audiology
- speech and language therapy
Every Nemours pediatric otolaryngologist has extensive training and experience in treating wide range of ENT conditions in children, from the most common (ear tubes surgery and tonsillectomies) to complex (hearing loss). Our highly skilled ENT surgeons perform specialized procedures that are unique to North Florida and the Southeast.
Highlights include:
- National recognition for a new life-saving surgical procedure for children born with an abnormally small jaw (a condition called Pierre Robin sequence, or PRS).
- First pediatric balloon sinuplasty procedure (a newer technology to treat sinus disease) in a child in Florida.
- Groundbreaking minimally invasive procedure to remove salivary stones in children.
We believe strongly in educating families and want you to know that you are an important part of your child's care team. We welcome your active involvement in the decision-making process. We also strive to make things as easy and convenient as possible for you and your child.
Because our ear, nose and throat doctors, audiologists and speech therapists are all under one roof, your child can often have multiple appointments scheduled in one day. You can also schedule appointments at our convenient specialty care locations in Jacksonville South and Fleming Island.
Our Pediatric ENT Programs and Services in Jacksonville, Fla.
A cochlear implant is a surgically implanted device for children with severe to profound hearing impairment who do not benefit from hearing aids. Our cochlear implant and auditory rehabilitation program is recognized nationally as a leading program for pediatric implantation and provides ongoing therapy and long-term support to children and families, both before and after cochlear implant surgery. We also collaborate in the community with the Clarke Schools for Hearing and Speech.
Learn More About Our Cochlear Implant & Auditory Rehabilitation Program »
We offer two implantable (surgically placed) hearing devices for children ages 5 and older, with conductive or mixed hearing loss. These devices can also benefit children with single-sided deafness — and both devices can be worn in a softband before age 5 or if implantation is not desired.
Bone Anchored Hearing Aid (BAHA)
The BAHA is a surgically implanted system that works through direct bone conduction and includes a titanium implant, an external abutment and a sound processor. The system enhances natural bone transmission as a pathway for sound to travel directly to the inner ear, bypassing the outer and middle ear.
The implant is placed during a short surgical procedure, which over time integrates with the skull bone (usually 3–6 months) depending on the age of the child. Once integrated, the processor (which is worn on the external abutment) transmits sound vibrations via the abutment to the implant. The implant vibrates, sending vibrations within the skull and inner ear. Hair cells within the inner ear stimulate nerve fibers, allowing hearing to occur.
Sophono Bone Conduction Hearing System
The Sophono is an innovative abutment-free device. This system eliminates the need for a protruding abutment by using a magnetic titanium implant, which securely holds the external processor in place through intact skin and hair via an external spacer magnet. The Sophono is implanted in a short, single-stage procedure. The processor can be fitted for the patient in about 4 weeks after surgery or once the incision has healed. Like the BAHA, direct stimulation to the inner ear via vibrations allows for hearing to occur.
Neurotology focuses on the neurological (related to the body's nervous system) aspects of the auditory (hearing) and vestibular (balance) systems. Working with the pediatric neurosurgery division at Wolfson Children's Hospital, we are one of only a few centers in the nation with expertise in treating children with balance problems (dizziness, falling or the sensation of falling, disorientation, or nausea).
Nemours Children's Specialty Care, Jacksonville houses the only balance facility dedicated to children in the region and our child-frienldy, state-of-the-art equipment helps us pinpoint both the cause and the most effective treatment for balance problems in children. Our balance lab is also a leading center for research in vestibular diseases in children.
Facial anomalies, or craniofacial disorders (irregular or abnormal growth of head and facial bones), are congenital (meaning present at birth) and include conditions such as cleft lip and/or cleft palate. Our program provides leading edge treatment and surgical procedures never before offered in our area.
These include a very successful "distraction" program for children with Pierre Robin sequence (PRS). PRS is a rare, life-threatening condition that causes the tongue to fall back into the throat, making it difficult for babies to breathe and swallow. Children with this condition often need a breathing and feeding tube until age 5, but our surgical team performs a state-of-the-art procedure that helps grow new bone in the jaw and treats the disorder by helping to expand the airway without the need for breathing or feeding tubes.
We also offer advanced treatment, unique in Northeast Florida, for children with vascular anomalies (blood vessels that have developed abnormally).
Learn More About Our Cleft and Craniofacial Anomalies Program »
Nemours provides specialized care for children with voice and swallowing disorders, including advanced endoscopic airway procedures which use a thin, flexible viewing instrument (endoscope) to provide an inside view of the airway. State-of-the-art voice and swallowing equipment allow our doctors and speech pathologists to evaluate and treat children with range voice and swallowing disorders, like Velopharyngeal insufficiency (VPI). VPI occurs when the soft palate muscle in roof of the mouth (velopharyngeal sphincter) fails to close off airflow during speech, allowing air to escape through the nose instead of the mouth. This can cause a resonance disorder or "nasal" speech. In our VPI clinic, our ENT team will diagnose the type and cause of your child's problem and recommend treatment that may include speech therapy, surgical correction or both.
The ENT specialists at Nemours perform the newest techniques available in treating nasal (rhinology) and sinus problems in children. These techniques include the latest endoscopic surgical procedures which use a thin, flexible viewing instrument (endoscope) to provide an inside view of the nose and sinuses. Our center was the first in Florida to use a new balloon sinuplasty procedure to treat sinus disease in children. Because nasal and sinus problems are common in children with cystic fibrosis (CF), we've also become a leading treatment center in Northeast Florida and Southeast Georgia for children with CF.
Working as a Team to Care For Your Child
Whether your child's ENT problem is straightforward (such as a chronic ear infection) or much more complicated (such as deafness), we practice medicine in a way that brings together skills and talent from different areas of expertise.
Members from different specialties throughout Nemours collaborate to create solutions to treat and meet your child's needs. Health professionals who may be involved include:
Our doctors and teams provide advanced ENT care that takes your whole child and not just the condition into account. We address areas and conditions that include:
Rhinology (Nose and Sinuses)
- acute and chronic sinusitis
- chronic nasal congestion (turbinate hypertrophy, or septal deviation)
- epistaxis (bleeding from the nose)
- choanal atresia (nasal obstruction)
- periorbital cellulitis/abscess (infection of the eyelid or skin around the eye)
- nasal fractures
- tumors and diseases of the anterior skull base
Facial Plastic Surgery
- rhinoplasty (nose surgery)
- otoplasty (ear surgery)
- cleft lip and palate
- velopharyngeal insufficiency (malfunction of the soft palate muscle in the mouth)
- neonatal ear molding (EarWell™)
Head and Neck
- malignant and benign tumors of the head, face and neck
- cervical adenopathy (enlarged lymph nodes in the neck)
- abscesses of the head and neck
- vascular malformations (abnormal clusters of blood vessels in the veins and/or lymph nodes)
- hemangiomas (abnormal clusters blood vessels in the skin or internal organs)
- congenital nevi (birthmarks)
- thyroid tumors
- salivary gland tumors and other salivary gland diseases
- drooling
- voice disorders including vocal cord paralysis
- hoarseness
- stridor (high-pitched breathing sound)
- dysphagia (difficulty swallowing)
- laryngeal papillomas (benign growths on the vocal cords)
- subglottic stenosis (narrowing of the airway below the vocal cords)
- laryngeal clefts (gap between the voice box and the esophagus)
- tracheal stenosis (narrowing of the windpipe)
- bronchial foreign bodies (swallowed items blocking the airway)
- drooling and aspiration (saliva in the lungs)
Otology and Neurotology
- vertigo (dizziness)
- auditory neuropathy spectrum disorder (problem with the transmission of sound)
- hearing loss
- facial paralysis/Bell's palsy
- mastoiditis (bacterial infection in the bone behind the ear)
- cholesteatoma (abnormal skin growth behind the eardrum)
- tympanic membrane perforations (ruptured eardrum)
- tumors and diseases of the lateral skull base
General Pediatric Otolaryngology
- recurrent otitis media (ear infections)
- adenotonsillar disease (tonsillitis, strep throat, obstructive sleep apnea)
- foreign bodies of the ears or nose
We also work together to address ENT-related concerns associated with complex conditions such as Down syndrome, cerebral palsy, cleft lip and palate and skeletal dysplasia.
Learn More About These and Other Children's Health Topics From Nemours KidsHealth.org »
Teaming Up With Wolfson Children's Hospital and Your Child's Doctor
A unique relationship with Wolfson Children's Hospital in Jacksonville, Fla. allows our Nemours ENT specialists to provide pediatric ENT consultations in the Emergency Department for acute problems or injuries, and in the hospital or outpatient surgery center for other ENT cases that require surgery and anesthesia.
During any procedure that requires anesthesia, rest assured that our Nemours pediatric anesthesiologists are right there to talk with you and to make decisions on the best types of anesthesia medicine to make sure your child is comfortable.
Our award-winning electronic health records and digital photography also make it easy for us to share test results and treatment plans with your child's primary care doctor, as well as with other Nemours specialists.


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The Bowers & Wilkins Panorama soundbar has been around for nigh-on three years now, so it's just about time for a refresh, don't you think? And, low and behold - that's exactly what the speaker company has gone and done.
The Bowers & Wilkins Panorama 2 is claimed to offer a "dramatically improved" acoustic performance over its forebear. It has all-new proprietary drive units, with low frequency drivers featuring improved linearity to the benefit of dynamism and lower resonance. While the mid-range drive units offer wider dispersion characteristics, expanding the virtual surround sound.
The tweeter has been improved to, in order to suit the new mid-range drive units.
Inside the bar, there are nine drive units in total, five used for the centre speaker; two subwoofers, two mid-range drivers, and an aluminium dome tweeter which features the firm's Nautilus tube-loaded technology.
The other four provide the stereo/virtual surround scape. They're each located in their own enclosures and powered by six class-D amplifiers. Total power output is 175-Watts.
There are three HDMI inputs on the Panorama 2 and one output, so it can serve as an entertainment hub/switcher. You can also add a separate subwoofer to really broaden the soundfield.
Bowers & Wilkins has also improved the on-screen display for the unit, and there's now a proximity sensor on the front which illuminates a control panel when you reach for it.
The soundbar will be available this month for £1,650.


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Burping a BabySkip to the navigation
Topic Overview
A baby may be uncomfortable after feedings if he or she has swallowed air during the feeding. Burping helps get rid of air that the baby has swallowed.
- Burp a breastfeeding baby when you switch breasts during feeding.
- Burp a baby who is bottle-feeding after each 1 fl oz (30 mL) to 2 fl oz (60 mL) of fluid.
- Burp the baby after the feeding is finished.
- If the baby has problems with gas or spitting up, you may burp the baby more frequently.
- Most babies burp readily on their own after 2 months of age.
To burp a baby:
- Place the baby in an upright position, such as over your shoulder or in a sitting position on your lap. If you place the baby on your lap, place your hand under the chin to support the baby's head.
- Gently rub or pat the baby's back. The baby will not always burp each time you do this. Wait a few minutes and try again.
- Sometimes formula or breast milk comes up with the air when the baby burps. A clean washcloth, cloth diaper, or bib can help keep you and the baby clean during burping.
To help the baby swallow less air during bottle feedings:
- Make sure the formula is not too hot or too cold.
- Hold the bottle so no air gets into the nipple.
- Sit the baby upright in your arms when feeding.
Related Information
ByHealthwise Staff
Primary Medical Reviewer William H. Blahd, Jr., MD, FACEP - Emergency Medicine
Kathleen Romito, MD - Family Medicine
Specialist Medical Reviewer John Pope, MD, MPH - Pediatrics
Current as ofMay 4, 2017
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What do brownies, bowling and batteries have in common?
They're my power sources. The sweet stuff: after the first bite, I'm ready to move mountains. The sport stuff: always an adrenaline rush since my league days with The Gutter Gals. The start-the-car-NOW stuff: my family has thousands of destinations — starting the ignition, hearing an empty-sounding click, then dead silence is something we don't need. Dead car battery. Get the jumper cables. Time for reviving a dead car battery and jump starting a car.
Never worked with jumper cables before for jump starting a car? (No worries ladies, we've all been there once.) A dead car battery doesn't discriminate. It'll happen some day, so take heed and learn how to jump start a car battery right:Turn off both carsConnect one of the red (positive) jumper cables to the positive terminal on the stalled car's batteryConnect the second red jumper cable to the positive terminal of the battery on the car giving the boostConnect one of the black (negative) jumper cables to the negative terminal of the boosting car's batteryConnect the other black jumper cable to the stalled car's engine blockStart the boosting car, let it run for a few minutesStart the stalled carOnce the stalled car starts, keep both cars runningIn reverse order, take off the jumper cablesKeep the jumped car running for half an hour (it'll give the battery time to recharge itself)
That is the art of jump starting a car and reviving a dead car battery. To further avoid the dead car battery dilemma, especially with winter around the corner, be proactive now. During bone-cold weather, a battery's ability to generate power naturally slows down. To make the problem worse, engines will need even more battery current to get started. Plus, the many demands of the defrosters, wipers and heater also increase the need for power. So check your battery's longevity level for winter! Test it with a voltmeter. Measure electrolyte levels. Remove corrosion from battery posts and terminals.
Lastly, keep those jumper cables in the trunk. After all, you now know how to jump start a car battery and an opportunity to be a Good Samaritan may arise at the parking lot, on the coldest night this winter. Then, after reviving a dead car battery, reward yourself. I say go for a fudge-nut brownie. Or two.
Editor's note: Is you power absolute??Advance Auto Parts offers loads of car batteries, services and solutions to serve just about every cold-cranking need. Buy online, have it installed free in store—most vehicles, most locations. (Sorry, we're out of fudge-nut brownies at the moment.)


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GTA 5 Theme is designed to help you customize your desktop appearance by displaying wallpapers inspired by the Grand Theft Auto V game when your computer is idle.
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text:
It is a sad fact that for many of us the prospect of getting old is quite scary. We look around and see old people hobbling slowly along the street and we look away. We think of retirement homes with distaste, if not with outright horror. Is that what will happen to us? Will we become old and sick and unable to function normally? We can hardly bear to think about it.
Of course, if we do think about it we can all identify old people who are mentally and physically active and lead satisfying lives. But it seems a matter of chance – some are lucky, some are not. Better not to dwell on it.
However, it is not a matter of chance – it's not about genes or bad luck, or being born into the wrong family. Studies by George Vaillant (2004) of the same people over 60 years show that aging well can be attributed to certain controllable factors, and they are not the ones we might think that they are.
He defined positive aging as consisting of six dimensions:
- absence of objective physical disability as rated by a doctor
- subjective physical health as rated by the person themselves
- length of undisabled life – whether the person had lost any years before age 80 to actual or perceived disability
- objective mental health as rated by success in work, love, play, and avoiding psychiatric care
- objective social supports – good connections with wife, children and grandchildren, siblings, playmates (eg golf, tennis, sailing) and social networks (clubs, etc) as rated by others
- subjective life satisfaction as rated by the person themselves
He used these dimensions to classify over 500 subjects from different class backgrounds (college and inner-city) along a continuum that ranged from "happy-well" to "sad-sick" at age 70-80. The happy-well tended to have high ratings in most or all of these dimensions; those with low ratings were more likely to be sad-sick, or had died before age 70-80. Then he looked at factors that had been measured earlier in their lives to see what contributed to this rating.
First let's look at what did not predict positive aging. The happy-well did not have longer-lived ancestors, higher cholesterol, higher social class, warmer childhoods, more stable childhood temperaments, or higher stress than the sad-sick. Contrary to what we would believe, better genes, low cholesterol, social class, upbringing, temperament and stress-free living do not contribute significantly to a healthy and happy old age.
So what did contribute to a happy and healthy old age? Each of the following variables were shown to lead to a positive old age, regardless of social class or other factors:
- Not being a smoker or stopping smoking before age 45. Not smoking heavily before age 50 was the single best predictor of healthy aging, but if they quit smoking completely before age 45 the effect at 70-80 was much the same.
- Using adaptive coping styles. Coping styles involve the use of defense mechanisms to deal with stressful situations. We all use them, but some, such as humour, altruism and stoicism are "more mature" than others such as denial and passive-aggression. It is more adaptive, and healthier, to laugh at misfortune than to deny it is happening.
- Not abusing alcohol. Alcohol abuse was defined as "the evidence of multiple alcohol-related problems" with family, work, health, and the law.
- Healthy weight. Weight was measured using the body mass index (BMI). Being overweight (BMI> 28) or underweight (BMI<22) class="blsp-spelling-error" id="SPELLING_ERROR_1">positive aging.
- Stable marriage. Getting to age 50 without divorce, separation or serious problems contributed to positive aging.
- Exercise. Regular exercise of more than 500 kilocalories per week was required.
- Years of education. Those with higher education tended to stop smoking, eat sensibly and drink in moderation because they were higher in self-care, future orientation and perseverance.
This is great news for all of us. All of these factors are controllable – we can ensure that we remain healthy and happy into old age just by controlling our smoking, alcohol consumption, weight and exercise, and by working on ourselves and our marriages to cope better with stress and setbacks. The fact that a higher education makes us more likely to do these things should not stop us just because we didn't go on to college or university.
Christopher Peterson. (2006). A Primer in Positive Psychology. New York: Oxford University Press.
Vaillant, George E. (2004). Positive Aging. In P. Alex Linley & Stephen Joseph (Eds.), Positive psychology in practice (pp.561-578). New York: Wiley.


text:
SOURCE: Binswanger
January 11, 2013 10:18 ET
ATLANTA, GA--(Marketwire - Jan 11, 2013) - Binswanger has been named exclusive agent by Lasco Manufacturing Limited for the sale or lease of a single-story 56,033 sq. ft. industrial building on approximately 2.17 acres situated at 300 West 15th Street in Anniston, Alabama.
The building was constructed in 1985 and expanded in 2008. Key features of the facility includes 6" reinforced concrete floor; insulated pre-engineered metal panel construction; 100' clear span steel columns in the original section and 45' clear span in the addition; ceiling heights to 20'6"; all utilities; metal halide and T-5 fluorescent lighting; approximately 2,000 sq. ft. of air-conditioned office space; seven tailgate high-truck doors with levelers, seals, and lights; two 12' x 14' drive-in doors; and parking for approximately 25 vehicles.
The property is located one-half mile west of US Highway 431 and four miles north of I-20. Birmingham Municipal Airport is approximately 65 miles and Atlanta Hartsfield-Jackson International Airport is approximately 100 miles from the site.
Binswanger is aggressively marketing the property to targeted prospects including manufactures of food, beverage and tobacco; wholesale trade; retail trade; transportation and warehousing; real estate, rental, leasing; administration/support and waste management remediation industries.
Headquartered in Philadelphia, PA, Binswanger is an international full-service real estate organization with offices worldwide throughout the United States, Canada, Latin America, Europe, the Middle East, and Asia.
CONTACT:Laurie Goldstein
215-448-6014Email Contact
CONTACT:Laurie Goldstein
215-448-6014Email Contact
See all RSS Newsfeeds


text:
[47:01] -
Lessons in leadership from those just starting out, plus Dr. Tim Irwin talks leadership impact, and a listener's mom is telling him to call it quits.
Featured musical artist: North Point Music
Comment on this week's show
[18:10] -
You may have a big title and manage a bunch of people, or you may be responsible for just yourself. Leadership comes in many forms, so what does it look like for those who are just starting out on their journey into adulthood? A panel from our Focus Leadership Institute (featuring our wonderful interns Nikki and Jenny) shares what inspires them to lead, both now and in the future.
[20:39] -
Not all leaders are good leaders. The truly successful ones have not only authority, but influence. Dr. Tim Irwin helps leaders affect change in themselves and the people they're called to lead. He shows them how to make more than just decisions; he shows them how to make an Impact. Listen in as he shares some of his wisdom.
[5:16] -
He really likes his girlfriend, but his mom has a different opinion. In fact, she says she has a "feeling from the Holy Spirit" that the relationship's not to be. Should our listener take his mom's prompting seriously, or is there another solution? Counselor Glenn Lutjens weighs in.
Helping young adults mature in Christ and prepare for marriage and family. Learn more
© Focus on the Family 1998-2018


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WASHINGTON – We are all worried about President Obama.
If he is to fix our fiscal problems, do something about Syria, Iran, North Korea and the Middle East peace process, and also co-manage the upbringing of two teenage girls, some changes must be made.
After covering the White House for years and reading copiously about the problems of previous presidents, I have some suggestions that some of them tried.
While golf is the sport of presidents, most Americans do not (cannot afford to) play, and may resent political leaders being seen golfing while the rest of America is standing in lines trying to get health insurance.
But several presidents played bocce ball on the White House lawn. Now, this is a sport that House GOP Speaker John Boehner knows well (he is from Ohio). A meeting of minds between our politically divided leaders over bocce ball might work.
President Reagan spent more than a year of his 8-year presidency at his beloved California ranch. He never actually moved the seat of power to Rancho del Cielo, but he would have liked to do that.
Obama grew up in Hawaii and vacations there every year. Moving the official White House there would take a lot of pressure off Obama because most Americans never think of Hawaii unless they are there on honeymoons or 50th wedding anniversaries. Some tea partiers do not even believe Hawaii is a state.
Some presidents started wars, including a pre-emptive war or two. This is not a good idea for Obama, although many Canadians are angry that he hasn't made a decision on the Keystone pipeline extension.
But he could declare an exciting new peace agreement with Burkina Faso, which would include tinkertape parades, elaborate signing ceremonies, and a gala ball with many Hollywood celebrities, even including Republican movie stars who haven't been inside the White House since the Reagan years. This would give the media days of diversionary delight.
With one of Obama's major goals, immigration reform, still unresolved, he might challenge every member of Congress to adopt a Hispanic student who is a high school valedictorian but whose parents are undocumented. The lawmakers immediately would pass immigration legislation to enable those new family members to get all the benefits of citizenship, perhaps even free college.
Boehner, who often mentions how hard he worked as a youngster alongside his brothers sweeping floors in his father's bar and understands the difficulty of feeding a lot of mouths, already he is signaling he is interested in doing something about immigration.
When President George H.W. Bush wanted to spur the economy, he went on a shopping spree in Maryland and bought socks. While this did not prompt millions of Americans to buy new underwear, it did promote a lot of talk.
Obama has bought books in public, but if he went to every Sears store and purchased automotive gear, such as windshield wipers or battery trickle chargers, this would remind Americans that he saved the U.S. auto industry.
President Clinton pardoned a notorious felon, which was hugely controversial but sort of made people forget that he took a lot of White House furniture when he left office.
Obama could grant whistleblower/traitor Edward Snowden clemency. This would rock the globe. Half the world thinks Snowden rightly disclosed the huge scope of National Security Agency spying. The rest think Snowden betrayed his country and must spend his life in prison, if he ever goes back to the United States. Obama's action would be so controversial it would consume Fox News and MSNBC.
Or Obama could do nothing about Snowden and get the same result.
At the least Obama could follow the precedent of recent presidents and declare popular opinion polls fleeting, indicative of nothing and not worth the computer time it takes to tabulate them. Until the polls change in the president's favor. At that point, the people have spoken.
Note to readers – Ann McFeatters has covered the White House and national politics since 1986. Readers may send her email at email@example.com.


text: Currently the contents of the main.cf config for postfix seems to be hardcoded into the installer_base library and the operating system specific ones. This means the main.cf is overwritten on each update/install. Would it be an option either - to make a config template for the main.cf that can be overridden in the conf-cust dir - and remains the same during update or - to add some config option questions into the (expert mode) installer for the postfix conf To be more specific: Code: smtpd_sender_restrictions = check_sender_access mysql:'.$config_dir.'/mysql-virtual_sender.cf At nearly all servers I use something like Code: smtpd_sender_restrictions = check_sender_access mysql:/etc/postfix/mysql-virtual_sender.cf, reject_invalid_hostname, reject_non_fqdn_hostname, reject_rbl_client zen.spamhaus.org So I have to keep in mind adding these options every time again when updating ispc.


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2007 Sealine F42/5
- Description
- View Full Specifications
- Year:
- 2007
- Hull Material:
- Fiberglass
- Length:
- 45'
- Engine/Fuel Type:
- /
Unconventional and endlessly versatile, the F42/5 sets new standards of excellence for flybridge cruisers.
Additional Specs, Equipment and Information:
Hull Shape: Deep Vee
LOA: 44 ft 10 in
Beam: 13 ft 10 in
Headroom: 6 ft 4 in
Dry Weight: 26014 lbs
Engine Options
Engine Option 1: 2x Volvo D6 - 370i
Fresh Water Tanks: (166 Gallons)
Fuel Tanks: (372 Gallons)
Additional Description
- Access to large lazarette
- Access to side decks via teak laid steps
- Bathing platform teak laid with built in storage locker
- Canopy in blue canvas
- Door to saloon, curved and sliding in toughened glass
- Ensign socket and staff
- Fender locker
- Gas bottle locker with drain
- Handrails in stainless steel
- Lazarette access leading to engine room
- Overhead lighting
- Seating with storage below
- Sealine concealed canopy storage system
- Sealine Extending Cockpit System(SECS?) and bathing platform
- Stairway to flybridge, moulded with teak treads
- Swimming ladder
- Table with storage locker on underside of flybridge
- Teak laid and self-draining
- Transom door to port
- Transom shower with hot and cold water
- Wetbar with sink, mixer tap and cupboard
Additional Description
- Access to engine room through floor hatches
- Bar unit and aft saloon unit, countertops finished in Corian?
- Electrical control panel for 220V and 12V circuits
- Fuel shut off valves in step
- Lighting, overhead
- Radio/CD player with (2) speakers and linked to flybridge
- Seating U-shaped to stbd converts to double berth with storage below
- Seating, port side (2) seater sofa
- Socket, 220V
- Storage cupboards
- Table height, adjustable with folding top
- Window, electric
- Blinds, pleated, starboard cabin,
- Blinds, venetian, saloon
- Interior linings, Sydney
- Carpeted saloon and cabins
- Cherry wood galley, lower helm and steps
- Curtains, front cabin and patio door
- Exterior colour package, blue Sunbrella? canopy, white cushions
- Furniture, cherry finish
- Galley and Saloon work surfaces, Corian?, Canyon
- Saloon complete with scatter cushions (4)
- Toilet and shower work surfaces, Corian?, Atlantis
- Upholstery seating, Primma
- Note: the select range of furnishings is offered as standard
Additional Description
- AC system, 220V with shore support system
- Air horns
- Batteries - domestic and starboard engine 2 x 165 Ah
- Batteries - port engine 1 x 165 Ah and 1 x 100 Ah with battery link switch
- Battery charger, 45 amp
- Calorifier with immersion heater
- DC system, 12V
- Fresh water pump
- Remote control spotlight
- Trim tabs with indicator at both helms
- Windscreen wipers, (2), with screen wash
- Water gauge
Additional Description
- Counter top in Goppian
- Fridge
- Floor in teak and holly
- Lighting, overhead
- Oven and grill, gas
- Port hole, opening
- Sinks, 70/30 with mixer tap and Goppian lids
- Socket, 220V
- Storage cupboards
- Storage under floor with modular drawer (2 cabin only)
- Stove, gas (2) burner
- Waste bin
Additional Description
- Access hatch to engine room from cockpit and saloon
- Bilge pumps, automatic and manual
- Engine room sound proofing
- Engine room fans
- Engine room and lazarette lights
- Fuel tanks in marine grade aluminium alloy
- Fuel filters for both engines
- Fire extinguisher system, automatic, in engine room
- Steering, hydraulic
- Water tanks in stainless steel
Additional Description
- Anchor, 16 kg Delta with 40 m of chain
- Anchor locker, self-draining with fender storage
- Bow fairlead
- Cleats, (8)
- Deck, moulded non-slip
- Fendering strip in stainless steel
- Foredeck hatch, opening
- Navigation lights, full set
- Pulpit and side rails in stainless steel
- Sealine concealed anchor stowage system
- Windlass, reversible electric
- Windscreen and side windows in toughened glass with stainless steel frame
- Access to cockpit via sliding hatch
- Cover for dash, seating and sunbed
- Drinks holders
- Ensign socket and staff
- Handrails in stainless steel
- Helm seat, twin, adjusts and swivels with stowage for table
- Radar mast, fibreglass
- Seating wrap around opposite the helm
- Speakers linked to the saloon
- Storage locker
- Sunbed with adjustable forward facing seat backrests and rear facing sunseat
- Table, removable
- Windscreen, curved and tinted
- Boat hook
- Clock and barometer
- Exterior covers, white in colour
- Fenders, (6) with Sealine logo
- Fire extinguishers, hand operated (2)
- Mooring ropes, (2)
- Sealine Owner's manual
- Window screen cover, white in colour
*This price is based on today's currency conversion rate.
Email Us
Please enter a valid name!
Please enter a valid email address!
RE: Sealine F42/5
Message cannot be empty!


text:
Open topic with navigation
TheSchedule/Personalize Item dialog has several options which can be used to determine which items will be displayed under certain conditions.
The Schedule/Personalize Pop-Up Menu Item dialog has the following options:
Subsites - Choosing from this section allows you to determine which items will be displayed based on what subsite that page is located in.
SubSite Levels – Choosing this allows you to determine how many levels deep from the current subsite should the item go before it is not displayed.
Variable Comparison – The Variable Comparison option allows you to schedule based on different variables and values.
Related Links
You can download PDF versions of the Content Contributor's, Administrator's, and Elements Reference documents from the support section of paperthin.com (requires login).
For technical support:
Open topic with navigation


text:
Any business that relies on personal connections, such as real estate or accounting, is perfectly poised to capitalize on social media. Yet these industries, which some might characterize as "old school," have not fully embraced the popular networks like Facebook, LinkedIn and Twitter. SocialBios helps any company provide its potential customers with a way to find connections to the people within the company by using social APIs.
When users visit a real estate brokerage in search of an agent, the company can use SocialBios to provide a way to sort the potential agents by social connections. A user authenticates with one or more social networks, then mutual friends and interests determine which agent shows up on top. "All we're doing is showing what's already there," Founder Ernie Graham said. "We're forced to start ranking that."
And that's exactly what happens on group pages, such as the real estate example above. The agents join SocialBios, as anyone can, creating a profile page aggregated from as many networks as they connect. Then, an administrator adds them to a group page, which can be embedded into a page on a company's site or accessed directly on SocialBios.
"It's amazing how a probable stranger can find someone with whom they have material social capital," Graham said. Graham has used the Telluride Properties page to demo the service for some time, flying blind as he lets the stranger connect to the various services. More often than not, Graham said, the person had matches with someone from this real estate company in a small, remote Colorado city.
There is a big difference between working with a stranger and someone with whom you have something in common--yes, even if that something happens to be that their friend went to the same school as you. That's the power that these social networks bring to service businesses.
The recent move to iframes and away from FBML made it easier for SocialBios to take its app to Facebook, powering the "about us" tabs on Facebook company pages, such as the this page. Since a user is already authenticated on Facebook, the connection to one's Facebook friends is implicit, but users are still given the chance to connect to additional networks.
Now SocialBios is also using its technology, both on Facebook and on its own site, to connect companies to job seekers. Once you know your connection to a company, you know who to contact to request a referral. This personal connection, much as it helps in finding a real estate agent, is better for the company and the job seeker (as well as the referrer, who usually gets referral fee).
As Graham noted, the data is right there. The APIs help expose it and help connect you to your customers, job candidates or future real estate agents.


text:
DC Entertainment 2014 FREE COMIC BOOK DAY Selections AnnouncedThu, 12/12/2013 - 7:00am |
Yesterday, DC ENTERTAINMENT announced THE NEW 52: FUTURES END will be one of their Free Comic Book Day titles for 2014. In addition, TEEN TITANS GO! #1 will be available at participating comic shops across the country for children of all ages.
So get ready for Free Comic Book Day 2014, which takes place the first Saturday of May!


text:
Snow Drawings
They're like Nazca lines, but far more ephemeral. Sonja Hinrichsen, with the help of five volunteers, cut spiral designs into the snow at Rabbit Ears Pass, Colorado. Who could imagine that snowshoes could be the implements of an artist?
Link and Artist's Website -via Colossal (where there's a video)


text:
Live Chat with a Bestop Expert (9-5 Mountain)
Or Create an Account
Enter your vehicle info So we can recomMend the right products for you.
Can't find your vehicle?
Tell us what you think. Click on Write a Review below in order to submit your own.
0% of customers would recommend this product (0 out of 0)


text:
Beaumont/Port Arthur
Some criminals never learn, and Orange has definitely had its share of repeat offenders. This week, a man arrested for public intoxication and for suspected PCP use in January was again arrested in Orange, this time after reportedly stealing a car.
While we harbor no disrespect for the Wall Street Journal who called us "that scrappy little paper from Southeast Texas," we prefer to think of ourselves as simple seekers of the truth. We're of the opinion that headlines and sound bites never tell the whole story. Our readers demand all the facts, facets and flavors of every story or event. And, they expect to be informed, educated and stirred to action.
For this week's New York Times crossword puzzle, pick up a copy of this week's The Examiner on newsstands now.


text:
This Site has a huge amount of computer related books free to read or download.
Some of the categories are:
Computer Languages
Computer Science
Databases and Storage
Electronic Engineering
Java and Java EE (J2EE)
Linux and Unix
Microsoft and .NET
Mobile Computing
Network / Communications
Software Engineering
Web Design and Programming
With lots of books in each. Its well worth a look.


text:
Are your tires bald? Is your car pulling to the right? Have you gone 3,000 miles since your last oil change? Tri-Cities Battery and Auto Repair in Kennewick, Washington, offers all the auto services and tires you need, right here under one roof. They are a certified dealer of Yokohama, Interstate Batteries and Michelin®, and they stock tires for cars, trucks, SUVs, vans, and more.
Motto: "Essence of Auto Care"
Founded: 1971
Why They're Unique: They have more than 30 Services to provide our customers!
They Can Answer Questions Relating to: Tires, batteries, auto service, cooling system mainetenance and diagnostics.
Meet The Expert
Tri-Cities Battery Inc., is a proud, family-owned business started by Dale W Johnson in 1971. The business at that time was one location in Pasco Washington concentrating on the sale and installation of batteries – both retail and wholesale.
Today, Gerald and Pat Johnson (second generation) and their sons Brandon, Derek and Adam (third generation) continue to operate Tri-Cities Battery with grandfather Dale's ethics, customer service and pride.
As with anything change is needed and as the area evolved and grew, so did the business to keep up with the times. Today Tri-Cities Battery has three locations and has changed the scope of business from just battery sales & installations to complete automotive repair, alignments tires & wheels.
To identify that Tri-Cities Battery was now more than just batteries a name change was needed; "Tri-Cities Battery Inc, Auto Repair & Tire Center" was chosen to reflect the new products & services offered.
Have A Question? Ask The Experts!
(509) 783-9000
View Larger Map
(509) 545-1473
View Larger Map
(509) 628-9550


text:
Search our database of handpicked sites
Looking for a great physics site? We've tracked down the very best and checked them for accuracy. Just fill out the fields below and we'll do the rest.
You searched for "ai", type: Website
(of which 1 is a Websites, 0 are Videos, and 0 are Experiments)
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Jabberwacky - communication, companionship, intelligence
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text:
When I went foraging with Philip Stark and Tom Carlson for what became the first of the California Matters series of videos, I had an idea of what to expect. I spent a lot of time in Vermont in the '70s and, armed with Euell Gibbons's Stalking the Wild Asparagus, I learned about eating dandelion leaves, roots, and the base where they met, as well as crowns and even the little balls of unbloomed flowers (actually the best part, sautéed). I learned, too, about milkweed, a plant that can be eaten at several stages.
Most of the other ostensibly easy-to-find plants, however, remained elusive, largely because I found books inadequate for identification purposes and I had no guide – I was on my own. (I was finally shown wild asparagus by Lidia Bastianich in Istria, Croatia, 30 years later.)


text:
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Every , 10:05 AM - 10:55 AM
We're here to engage fifth through eighth graders in a live-giving faith and to connect you with peers who are on the same faith journey. We teach the Bible in a relevant way and connect you with caring adults who can encourage you in your faith and guide you through life's challenges. Route 56 meets in the Spruce Room—on the right when you walk in the doors of the Weber Street Center. I-78 meets in the Cedar Room—toward the back of the building.


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So have you bought your Wine Festival tickets yet? It's coming up really soon. In fact, it's next weekend? How about your Beer Festival tickets? That one's only a couple weeks away. And of course, don't forget to experience BockFest starting tonight. Go see the Trojan Goat in the BockFest parade on Saturday!And in the spirit of BockFest, I opted for a Beer Photo!
The upcoming week is primarily about the Wine Festival that caps off the week (or begins the next weekend). You can still get tickets for some of the winery dinners, and the Cork n Bottle event with Michael Mondavi is not to be missed. Dep's Fine Wines (yes, Liquor Direct) is also hosting a winemaker on Wednesday evening. Dennis Hill from Perfecta and Cannonball wines is in town for, you guessed it, the Wine Festival. The Dep's event is free!
Remember, all the recurring events, those dependable weekly tastings, are displayed on our calendar. The one-time events are after the jump.
For information on what's going on in Dayton, you can refer to Mark's blog at Uncorked.
Local Wine Tasting Event Calendar
Friday Interactive Wine Tasting Map
Saturday Interactive Wine Tasting Map
Image used under Creative Commons from mccun934
Visit the BockFest website for the schedule of events and more information
Wine Tasting: Call for topic
Jungle Jim's
5440 Dixie Highway
Fairfield, Ohio 45014
1 pm, Prices vary per topic
Reservations required. (513) 674-6008
Traipsing through Beaujolais
The Party Source
95 Riviera Drive
Bellevue, KY 41073
This wine region just south of glamorous Burgundy is among the most misunderstood in the world. Beaujolais is a terrific wine, even a serious red wine and with real aging potential in the cellar. With the right selections, Beaujolais can pair with a wide range of hearty foods–at a fraction of the cost of its northern neighbor.
1-3 pm, $20
Reservations required.
French Regional Wine Tasting
20 Brix
101 Main Street
Milford, OH
6 pm, $45/pp
Reservations required.
(513) 831-2749
Exclusive Tasting with Michael Mondavi
Cork n Bottle
Buttermilk Pike Location
Crescent Springs, KY
We are pleased and privileged to bring to our Buttermilk Pike store our good friend, Michael Mondavi for a private wine tasting. Michael will be here to guide us through a sampling of his family's latest vintages from Napa Valley. He will also be signing bottle purchases of his collectible Cabernets. Appetizers, cheeses and hors d'oeuvres will be served throughout the evening to complement the wines. Come join us for this special event.
6:30 pm, $25
(859) 341 – 9600
RSVP Required. firstname.lastname@example.com
Meet the Winemaker: Cannonball and Perfecta Wines
Dep's Fine Wines (formerly Liquor Direct)
90 Alexandria Pike
Fort Thomas, KY
Dennis Hill from Cannonball and Perfecta Wines joining us for an impromptu wine tasting at our Fort Thomas store. Reservations available. It's free of charge. Contact email@example.com to reserve your seats now.
Bartending 102 with Josh Durr
Tonic on 4th
125 West 4th Street
Cincinnati, OH
A Crash Course in the Foundations of the Professional Bartender
5:30 – 8:30 pm, $55
Reserve via Ticket Derby
More info: (513) 721-1345)
Toast for Hope Wine Tasting Fundraiser
Benefits Women's Crisis Center
Carnegie Visual and Performing Arts Center
1028 Scott Blvd.
Covington, KY 41011
Fine wines, gourmet hors d'oeuvres and live music.
5-7 pm, $60
More Information, 859-372-3571
Amarone & Friends: Italy's Dried Grape Wines
The Party Source
95 Riviera Drive
Bellevue, KY 41073
The Italians have a most curious tradition of drying grapes slightly before pressing them. The resulting red wines have a concentrated, powerful character, leading up to the king of them all, Amarone. Join Jay on a tour of Amarone and friends.
6:30 – 8:30 pm, $20
Reservations required.
Wine dinners for the CIWF:
DaVeed's at 934
Graziano Family of Wines
Tickets: $125
Eddie Merlot's
Kuletto Wines
Tickets: $125
The Hess Collection
Tickets: $150
Frank Family Vineyards
Tickets: $150
Morton's, The Steakhouse
Villa San Juliette
Tickets: $150
Orchids at Palm Court
Terlato International
Tickets: $125
Cincinnati International Wine Festival Grand Tasting
Duke Energy Convention Center
Grand Ballroom, 3rd Floor
525 Elm Street
Cincinnati, OH 45202
6:30 – 9 pm
$70.00 prior to event, $75.00 at the door
$105 for Grand Tasting ticket and Special Tasting ticket, $110 at the door
Mexican Classics: Tequila and More
The Party Source
95 Riviera Drive
Bellevue, KY 41073
Mexico's classic distillates, Tequila and Mezcal, are totally unique in the world of fine spirits. Along with Tequila Ocho–which ROCKED our world in 2009–you can taste the best añejo Tequila and rarest Mezcal. Viv-uh la May-Hee-Coh in the EQ!
6:30 – 8:30 pm, $20
Reservations required.
Wine Competitions Wine Book Club (WBC) Wine Judging Reviews Readings Whiskey Watch France Games Weblogs Wine Clubs Books RIP Repost WBW #65 Wine Glossary Wine Maps TasteCamp Web/Tech Marketing Uncategorized Legislation Recipes Florida Recession Wine Meet the Winemaker Greatest Hits Drink Pink! (BCRF) Holiday Current Affairs Television Spirits Photos Wine Shop Wednesday Contests Scotch & Whiskey History Disney Wine Tech Food and Wine Pairings Mad Men Monday Guest Writers Pop Culture Food and Drink Wine Blogs Knowledge Entertainment Dinner and Drinks Life Charity Benefits News Beer-Guy.net Special Events Beer WBW Local Wineries Cocktails Wine Shops Restaurants Travel Wineries Wine Notes Wine Events Weekly Cincinnati Wine Events Wine Misc Local Tastings Cincinnati
Krystal Pepper Memorial Scholarship Fund
Raising money for a scholarship fund in memory of Michelle's little sister who passed away in 2007


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Guidance for Current PPHR Applicants
The information below is targeted to current PPHR applicants to assist them during the application process. NACCHO provides technical assistance to current applicants including answering criteria clarification questions by email and phone, participating in monthly conference calls, and providing resources and best practices upon request. The links below contain additional resources that applicants may find useful for developing their application materials.
Visitors to this page should already have submitted an Intent to Apply form and confirmed an application submission date within the next year. If you are not currently working with NACCHO on your PPHR application, please visit the prospective applicants page for more general information on the program.
PPHR Application Process
Application Resources


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Chaplains' corps seeks volunteers
The local Emergency Services Chaplains Corps is looking for a few good men and women to lend a hand — and a shoulder — when tragedy strikes in the Crossroads area.
Chaplain Joel Miller, who handles the training of prospective chaplains in the program, said the group is looking for area volunteers to help fill the gaps sometimes left amidst tragic situations.
"The program is carried out by volunteers and works through grants and local donations," Miller said. "We used to wait to hold classes until we had enough trainees, but we've changed the way we do that. Now, we train them on an individual basis year round, which really allows for a better experience for everyone."
Miller said chaplains with the program often help fill a very tough void in the lives of people who find their lives shaken by tragedy.
For more information, you may subscribe to the Big Spring Herald or purchase an e-edition.


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"Order the JF303 Walnut Lamp Table BY 2:30pm for Next Working Day Delivery in the UK"
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**Restrictions apply please see delivery information for more details**
This wonderful lamp table combines natural wood veneer and modern 'Piano Black' glass. The JF303 blends contemporary style with practicality, offering open storage for everyday items. Designed to match the popular JF301 Coffee Table.
Take a look through all of our Collections in the "Related Products" section below, to see the full range.
Real Wood Veneer –Toughened Safety Glass – Minimalistic Design - Complements Jual Curve Range - Self Assembly
Diameter 610mm x H457mm
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We cannot accept responsibility for any losses or costs incurred as a result of late deliveries regardless of the cause. We will do our utmost to ensure our customer is kept informed at all times and try and resolve the issue with the couriers at the earliest possible time.
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Sports fans and their funny signs
Some of the fun of going to a professional sporting event is showing your allegiance to your team, whether it is with a team jersey, cheering or fashioning your own sign to show off. Here are some recent ones that caught our attention.
Copyright © 2018, RedEye Chicago


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As hedge funder David Einhorn continues to press a shareholder revolt against Apple
On Wednesday, VirnetX
VirnetX's patent infringement claim stems from Apple's FaceTime chat program, which is currently a popular feature on the company's iPhone 5, iPad, and iPod mobile devices and its iMac and MacBook PCs.
With the court ruling, VirnetX will receive about $330,000 per day until it can reach a royalty agreement with Apple on the patents. It doesn't appear Apple will be able to challenge the court's ruling, which affirms a late November jury decision in VirnetX's favor.
"We are extremely pleased with the outcome of our suit with Apple," said Kendall Larsen, VirnetX CEO and president. "This victory further establishes the importance of our patent portfolio."
While the $330,000 daily payments or a royalty agreement are unlikely to dent Apple's financials, the ruling represents what could be a major revenue stream for the company in coming quarters as it continues to spend on its patent monetization efforts.
The patent infringement claim affirms VirnetX's position as a key player in the legal fights currently underway in Silicon Valley.
The company, which has been publicly traded since the late 1990s, has seen its shares recover from low single digit stock prices as a patent litigation for features on mobile intensified in recent years.
In the past five years, VirnetX's shares have surged nearly 600%. The company began to successfully litigate major patent infringement claims against the likes of Apple and Siemens (NYSE:SI)
Unlike Einhorn and his fight against Apple for a preferred dividend, VirnetX's battle against tech sector titans is unlikely to end anytime soon.
In March, the firm will pursue infringement claims against Cisco
In January, William Blair analysts highlighted that the Siemens ruling, and a licensing agreement with the Enterprise Communications division of the German conglomerate may help VirnetX in getting royalty agreements with Cisco and Avaya for its IP private branch exchange patents.
VirnetX shares rose over 5% to $35.91 in early afternoon trading on Wednesday. After big 2012 stock gains, VirnetX's market cap now stands at $1.84 billion.
Apple has not yet responded to TheStreet's request for comment on this story.
- 1
Daily Recap Newsletter
entertainment, education and
smart market commentary.


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Avebury, Delphi, Ryoanji and Salisbury Cathedral Cloister are sacred places. But are they also gardens? Yes: they are enclosed outdoor spaces; they were designed to be beautiful; they were not made for functional horticulture.
Sun, shadows, water, plants and structures are intrinsic to their design. Ryoanji, you might say, is a dry garden. Yes it is, but moss grows around the famous stones and the play of tree shadows on the gravel is part of the fascination.
According to Wikipedia "Holiness, or sanctity, is the state of being holy or sacred, that is, set apart for the worship or service of gods. It could also mean being set apart to pursue (or to already have achieved) a sacred state or goal, such as Nirvana. It is often ascribed to people, objects, times, or places." I have one quibble with this definition: the Buddha did not recognize a god and Buddhism is the world religion which has had the most influence on garden design.
In a demythologised sense, if you wish, I believe that sacredness remains a vital concern in garden design. We want to have places which are 'set apart' from the everyday world of bustling stress, which fill the soul and solace the flesh. I wish those who plan suburban subdivisions and housing estates had an appreciation of how space can be 'set apart' and yet connected.


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Amnesty International Urges Israel to Abandon Expansion of Settlements in East Jerusalem
Oct 15, 2010, 03:38 ET
Says Expansion Would Compound Human Rights Abuses of Palestinians in Occupied Territories
NEW YORK, Oct. 15 /PRNewswire-USNewswire/ -- Amnesty International today urged Israel to abandon plans to construct 238 new housing units in Israeli settlements in occupied East Jerusalem.
(Logo: http://photos.prnewswire.com/prnh/20081014/AILOGO)
(Logo: http://www.newscom.com/cgi-bin/prnh/20081014/AILOGO)
"The Israeli authorities must immediately halt expansion of settlements in East Jerusalem and the rest of the occupied West Bank," said Philip Luther, Amnesty International's deputy director for the Middle East and North Africa.
"Not only does the building contravene international law, it also compounds the litany of abuses of the human rights of Palestinians living in the Occupied Palestinian Territories, including their rights to adequate housing and water."
The 238 new housing units are planned for the large settlements of Pisgat Ze'ev and Ramot, established in 1984 and 1974 respectively. Pisgat Ze'ev now has over 40,000 residents and, like Ramot, its services are provided by the Israeli Jerusalem municipal authority.
The plan for 80 units in Pisgat Ze'ev and 158 in Ramot was announced Thursday by the Israel Lands Administration and the Israeli Ministry for Construction and Housing. According to the Israeli media, Israel's Prime Minister Benjamin Netanyahu had approved the plans.
Although the areas of Pisgat Ze'ev and Ramot were not covered by the recent freeze on settlement construction, which excluded East Jerusalem, all settlement building on occupied land is illegal under international law.
Israel unilaterally annexed 70.5 square kilometers of occupied land in East Jerusalem and its environs following the 1967 war.
Israel's land grab and dissection of the West Bank, including East Jerusalem, have had a devastating impact on the lives of Palestinians. In East Jerusalem, 35 percent of the land has been expropriated for settlements in which 195,000 Israelis live. Meanwhile, more than 250,000 Palestinians are designated only 13 percent of East Jerusalem, which is already heavily built up.
Amnesty International is a Nobel Peace Prize-winning grassroots activist organization with more than 2.8 million supporters, activists and volunteers in more than 150 countries campaigning for human rights worldwide. The organization investigates and exposes abuses, educates and mobilizes the public, and works to protect people wherever justice, freedom, truth and dignity are denied.
For more information, please visit: www.amnestyusa.org
SOURCE Amnesty International


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BPOLST 500 - Policy Process
BPOLST 501 - Public Finance and Budgeting
BPOLST 502 - Statistics for Policy Studies
BPOLST 503 - Policy Analysis and Program Evaluation
BPOLST 504 - Management & Organizations
BPOLST 506 - Capstone Research
BPOLST 508 - Capstone Project
BPOLST 500 - Policy Process (5 credits)
This course focuses on political and institutional aspects of public policy process. We will examine reasons for public policy, how they are articulated and negotiated, who formulates public policy, what generic policy instruments are chosen, and how policies are implemented.
We will employ multiple ways of learning to build a broad knowledge of current policy issues across policy arenas and government levels. We will focus on development as a public policy goal. This will allow us to study a host of economic and social policy issues related to stimulating development and/or resulting from development. Through your individual research project and our case studies, you will gain detailed knowledge of the process of defining the public policy problem, identification of key stakeholders, institutions that could address this problem, and policy instruments that could be implemented.
BPOLST 501 - Public Finance and Budgeting (5 credits)
Analysis of government expenditures and revenues. Economic theory is used to examine key public policies in such as areas as health, education and labor. Emphasis is on policy rationales and impacts regarding efficiency and equity. Accounting concepts necessary for budgeting analysis are also developed.
BPOLST 502 - Statistics for Policy Studies (5 credits)
This course is the first in a series of two courses offered through the MA in Policy Studies program intended to train graduate students with becoming producers of information, i.e. a policy researcher. This course begins your training by surveying important aspects of the conduct of research into social scientific questions. This course lays the basic foundation for both academic and practical investigation. There are many benefits to taking this class that go beyond merely understanding statistical relationships.
There are several important goals tied to this course:
This class will provide you with information that will allow you to conduct further study on your own as you navigate your way through choosing and executing future research projects in upcoming classes, and most importantly, your capstone project.
BPOLST 503 - Policy Analysis and Program Evaluation (5 credits)
Public sector across levels of governance is under increasing pressure to provide better services with fewer resources. Policy analysts and public managers, therefore, need to be able to prioritize what services will be offered and evaluate whether the programs designed to provide such services have been effective and efficient. This course focuses on methods and approaches used in policy analysis and program evaluation.
We will examine and apply most commonly used interdisciplinary approaches and methods for evaluating policy impacts and outcomes, including, but not limited to cost-benefit analysis, randomized field experiments, quasi-experimental assessment, and participatory assessment. In addition, we will examine the role of policy analysis and program evaluation in democratic governance.
BPOLST 504 - Management & Organizations (5 credits)
Within this course students will have the opportunity to learn how organizational cultures, processes and resources frame the options open to leaders and managers in public, private and non-profit organizations, and how, in turn, an organization's leaders and an organization's strategies, perspectives, and patterns of resource management shape potential organizational responses to a variety of policy issues and problems. The larger global and regional challenges confronting organizations also require organizations and managers to learn new skills and to think differently and strategically about their non-profit, public and private sector organizations and their environments. Further, the course seeks to help students who will play important roles in such organizations to learn the leadership and resource management skills they will utilize in their professional careers.
Through the integration of theoretical and analytical frameworks with case studies, field experiences, applied research, discussions, workshops, and on-line skill-building modules, students in this course will learn to reflect and act as organizational leaders concerned with approaching and managing a variety of contemporary problem-solving issues and policy-related concerns. Major materials for this course will be provided through case studies, quantitative and qualitative skills modules (available on-line as well as for in-lab practice and discussion), and applied field experiences in regional organizations (including at least two of the three principal types of organizations concerned with policy issues - public, non-profit and private).
BPOLST 506 - Capstone Research (5 credits)
In the penultimate core course in the Master of Arts in Policy Studies, students will be conducting directed research in preparation for writing their final capstone project research paper. Aside from two workshops, there is no group seminar portion of the class; students meet one-on-one with their capstone advisors. Some students will be engaged in formal internships, while others will be conducting independent research. Faculty capstone advisors will consult with each other and the students to provide basic guidance as students move through the process of gathering and preparing data and evidence for the project.
BPOLST 508 - Capstone Project (5 credits)
The last core course in the Master of Arts in Policy Studies is devoted to final preparation of the capstone project. Students will meet regularly to share research findings, read chapters, and address problems and issues of final presentation. The course culminates in the final presentation of their work in front of an audience of peers, faculty, outside site supervisors, interested scholars, and community practitioners.


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text: How can I tell if my solar HVAC system is performing to its maximum potential?The communication module on your SunSource® Home Energy System sends the system's performance information for each module to a website. You may visit this website to learn about the system's status, energy production and environmental benefits. The site also shows carbon offsets as it happens.