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Taking the blinders off
The search for better drugs
Editor's Note: This story, originally published in 2005, has been updated.
"We are truly a blind man and the elephant," says Christopher Austin, M.D., of the National Human Genome Research Institute.
The human genome may encode a million distinct protein targets, yet only about 500 of them have been "hit" by small-molecule drugs. Scientists are only beginning to understand how drugs aimed at a single target may affect diverse physiological pathways and systems.
"If you pull one lever, it's going to have an effect on another lever, which is connected to two other levers," Austin says. "Before you know it, you've pulled the tail of the elephant and you've made the elephant's brain mad, and the elephant is going to pick up his foot—which you don't know exists—and stomp on you ...
"You can see the leg coming up in the air, but you say, 'Is that really a leg coming up in the air? I didn't know that was there.' You don't know until it lands on you," he says.
That's what happened with the selective COX-2 inhibitors Vioxx and Bextra, Austin says.
The drugs were developed to relieve arthritis pain and inflammation without the gastrointestinal side effects of traditional anti-inflammatory drugs, which block both cyclooxygenase (COX) enzymes. Only after millions of people had taken the drugs for years did it become apparent that they increased the risk of heart attack and stroke.
"What we still really lack in the whole drug discovery/drug development pipeline is good enough predictive toxicology," says Daniel Liebler, Ph.D., director of the Vanderbilt Proteomics Laboratory.
"We can certainly give a very toxic drug to a rat or a mouse or a dog, and observe classic signs of toxicity (such as) changes in liver and kidney function tests," Liebler says. "But what we lack are good biomarkers for more subtle dysfunctions that will ultimately manifest themselves after the person's taken the drug for six months… like with Vioxx."
Proteomics, the study of proteins, is one avenue toward that goal.
In the last few years, through such technologies as mass spectrometry, scientists have identified protein markers that seem to correlate with the emergence or progression of certain diseases, and with the response of disease to treatment.
In a mouse model of breast cancer, for example, Vanderbilt researchers have shown that the level of several proteins plummeted within 12 hours after administration of Tarceva, a cancer drug that blocks the receptor for epidermal growth factor. This suggests that the proteins may be "biomarkers" for tumor growth.
"You could see these changes… way before any surgical or MRI (magnetic resonance images) will show you there is tumor shrinkage," says Richard Caprioli, Ph.D., director of the Mass Spectrometry Research Center, who participated in the research.
More study is needed to determine whether a drop in the concentration of these proteins can be reliably correlated with tumor shrinkage in response to Tarceva. With the help of proteomics in the future, however, "we might be able to predict if a drug is going to be effective in a patient—even after the first dose," Caprioli says.
Watching drugs work
Imaging technologies offer another avenue for predicting the effectiveness of drug therapy.
Researchers in the Vanderbilt University Institute of Imaging Science are exploring dynamic contrast imaging, an MRI method that can create a three-dimensional image of angiogenesis, new blood vessel formation. When standardized, this method may provide a way to determine the effectiveness of anti-angiogenic agents, says institute director John Gore, Ph.D.
Vanderbilt recently installed a 7 Tesla magnet, 140,000 times the strength of the Earth's magnetic field, which will allow institute researchers to conduct magnetic resonance spectroscopy.
Using this technique, researchers can measure very precisely the levels of neurotransmitters in the brain. "We think that's an important area," Gore says, "not only for certain brain disorders such as addiction, but also for looking at the effects of drugs."
Positron emission tomography or PET is another imaging technology that is being harnessed for drug discovery. By tacking a radioisotope of fluoride or carbon onto a drug, for example, researchers can use PET to detect the radiation emitted by the labeled drug, and create an image of where it goes in the body.
Fluorescence imaging techniques, such as two-photon excitation microscopy, potentially provide a way to look into the living cell and watch what happens when a drug hits its target. This not only may aid drug discovery; it may salvage a promising class of cancer drugs called MMP inhibitors that were largely abandoned by drug companies after several clinical trials failed to show any survival benefit in patients with advanced disease.
MMP stands for matrix metalloproteinases, enzymes that are thought to contribute to metastasis, the major cause of cancer deaths, by helping to increase the tumor's blood supply and means of escape to other parts of the body.
Vanderbilt cancer researchers have developed a "proteolytic beacon" that can detect and measure MMP activity. The beacon is a fluorescent probe that releases a flash of fluorescence when split by the enzyme.
When an MMP inhibitor is given to block the enzyme, the beacon doesn't flash as brightly. In this way, the researchers hope to determine the dose of drug necessary to inhibit these enzymes, as well as which patients are most likely to respond to therapy.
Eventually, data from these studies will be integrated with data from genomic and proteomic studies to build "3-D models" that more accurately predict drug activity. "You're going to find a lot fewer things that take you down the wrong path," Piston predicts.
Sidelining the side effects
One of the biggest barriers to the successful launch of a drug is the adverse drug effect or unexpected side effect that may not become apparent until late in clinical testing or after marketing.
While the adverse effect may occur in only a tiny minority of patients, it may be serious enough that the drug company has no choice but to flush the entire effort—perhaps 12 years of work and up to a billion-dollar investment—down the drain.
Advances in genetic research may come to the rescue. In the late 1970s and early 1980s, Vanderbilt scientists led by the late Grant Wilkinson, Ph.D., D.Sc., identified some of the first polymorphisms, or genetic variations, in a group of liver enzymes called cytochrome P450s that metabolize or break down drugs in the body. Drugs are more likely to reach toxic levels in people whose enzymes do a poor job breaking them down.
Wilkinson and his colleagues, including Richard Kim, M.D., and David Haas, M.D., also discovered that a polymorphism in a drug-metabolizing enzyme gene impairs the ability to metabolize the AIDS drug efavirenz. This polymorphism is about six times more common in African-Americans than in Caucasians, which may explain why efavirenz blood levels are generally higher in African-Americans.
Individuals with this genetic variant tend to accumulate higher levels of the drug in their blood, and as a result they may experience mental confusion, strange dreams and other central nervous system disturbances, says Haas, director of the Vanderbilt AIDS Clinical Trials Center. The side effects can be so disturbing that patients stop taking their medication.
Pharmacogenomics—the study of how genetic differences affect drug response—may lead to more "rational" drug development and prescribing. "It may be possible in the not-to-distant future to screen a person's genome for polymorphisms that have clinical implications and then choose an appropriate regimen or an appropriate drug dose based on knowing their genetic background," Haas says.
Haas says the polymorphism that affects the metabolism of the AIDS drug could not have been discovered without the help of a national DNA "repository" established by the Adult AIDS Clinical Trials Group, a federally funded group of 34 centers in the United States, including Vanderbilt, which evaluates new AIDS treatments.
In 2000, Haas and his colleagues began developing a process for obtaining informed consent to collect an extra blood sample for DNA studies from patients participating in AIDS clinical trials. Since then, the repository, which is housed at Vanderbilt, has collected about 8,000 samples from different individuals.
As of 2005, about 10 genetic studies had been undertaken using the DNA samples. Information from these studies is being used to help develop a vaccine against the AIDS-causing human immunodeficiency virus (HIV), and to develop treatments that can rebuild or "reconstitute" the immune systems of patients that have been damaged by HIV infection.
"It's really just a glorious explosion of discovery," Haas says.
DNA on deposit
Vanderbilt also has joined forces with the U.S. Food and Drug Administration, the pharmaceutical giant GlaxoSmithKline and First Genetic Trust, a Chicago-based company that has pioneered DNA banking, to advance genetic-based medicines and diagnostics.
The goal: to expand the collection of DNA samples from patients who suffer a rare adverse drug event called long QT syndrome. The syndrome can lead to potentially fatal arrhythmias, abnormal heart rhythms.
When physicians anywhere in the country report drug-induced long QT syndrome to the FDA, the agency will refer them and their patients to Vanderbilt for participation in the study.
"We've been interested in this rare adverse drug effect for many years, with the idea that it is genetically determined," says Dan Roden, M.D., director of the John A. Oates Institute for Experimental Therapeutics at Vanderbilt and a principal investigator in the collaboration.
"The key first step in searching for genetic variants that may increase susceptibility is finding enough patients who have suffered this unusual event," Roden says. If genetic variants are found, it may be possible to develop diagnostic tests that can be used to identify in advance people at high risk for this side effect if they take certain drugs.
"Suppose there are three drugs for providers to choose from, and one of them shows that a genetic test will help you prescribe it better," he explains. "Most clinicians right now would rather just write the prescription for the other drugs and avoid genetic testing.
"Genetics is not going to be used to guide prescribing just because it makes sense. It will only happen if accomplished, forward thinking investigators, in partnership with the community, really push this forward and make it a reality."
William Evans, Pharm.D., director and chief executive officer of St. Jude Children's Research Hospital in Memphis, agrees. Evans and his colleagues pioneered the use of genetic testing to improve treatment of childhood cancers.
"The burden is on us at academic medical centers to begin to not only provide… evidence that these genetic polymorphisms are influencing significantly the drug response," Evans said during a lecture at Vanderbilt, "but to begin to incorporate that into treatment plans and protocols and to show… that it actually makes a difference."
Leigh MacMillan contributed to this story.
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Locals support proposed state-wide bullying hotline
Mental-health advocates support a local legislator's move to expand crisis services into a statewide bullying-specific hotline.
Rep. Mary Mascher, D-Iowa City, proposed the hotline last week in the Legislature, partially in reaction to the suicide of Iowa student Kenneth Weishum Jr., who was allegedly bullied for being gay.
"If a young person feels motivated enough to contact a crisis hotline, we need to make sure the support network is there," said Mascher, who proposed the initiative along with Rep. Beth Wessel-Kroeschell, D-Ames. "Whatever media they need — texting, online chat, or social media — we need to provide that."
Local crisis officials say the hotline would expand the Johnson County Crisis Center's efforts to combat bullying.
The Crisis Center provides a 24-hour crisis hotline and CrisisChat.org — available noon to midnight — on which individuals can contact a professional through online chat.
"I think one of the greatest resources statewide would be the Crisis Center's, but at this point, it's only available [noon to midnight] and expanding the existing program would provide an even greater resource," said Ross Wilburn, the equity director for the Iowa City School District.
Beth Ruback, communications and development director of the Crisis Center, said the center provides a great resource, but a statewide bullying initiative would give aid better-tailored to young people's needs.
"I think young people are more likely to search for support around a specific topic — bullying, an eating disorder, substance abuse, etc. — and might not think to call a 'crisis hotline,' " Ruback said.
She also collaborated with Mascher in developing the proposed hotline's online components.
"It provides a shield for young people to reveal a problem and tell us they're in a crisis," Ruback said. "Telling someone is often the most difficult thing. It's a great way for them to do it without any confrontation."
The Crisis Center received 1,496 CrisisChat.org requests from January to March this year — 409 in March alone.
"Unfortunately that far exceeds our capacity to respond," Ruback said. "The demand of that service is much higher than anyone anticipated. We're working hard to train more volunteers to answer."
Of the 1,496 requests, the Crisis Center staff could only respond to 497.
Mascher also said the potential statewide anti-bullying hotline could also face difficulties finding a large enough staff.
"Right now, we don't have a statewide system in place, and part of the problem is we don't have enough people to staff the hotline," Mascher said. "It's a real challenge, and we're trying to reach out and establish a program."
Schools have also sought to develop anti-bullying initiatives. Ryan Roemerman, executive director of the Iowa Pride Network, said schools can now apply for a Safe School Certification program once they have met all of the requirements of the Iowa Safe Schools Law — an anti-bullying act developed in 2007.
"We know that it really takes looking at a school in its entirety," Roemerman said. "It's not just one time and not just an assembly — that does not make your school safe. It takes an entire school effort and an in-depth program that really makes a school safe school over time."
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The July broadcast of Reform Radio featured John Felton, a 1975 OU graduate and freelance writer and editor. Felton has practiced journalism for almost 40 years, beginning in 1970 covering Dayton city hall for the Journal Herald, reporting on foreign affairs for the Congressional Quarterly in Washington, D.C., through the 1980s, and was a foreign desk editor and assignment editor for National Public Radio in the early 1990s. He also published a 730-page history of the Middle East in 2007. Since 2003 he has conducted quarterly reviews of its news coverage for NPR.
Reform Radio talked with Felton about his journalism career, particularly his roots in Ohio and his evaluations of NPR's coverage of sensitive news and issues, such as the invasion and occupation of Iraq, the failure of American journalism in the lead-up to the Iraq war, and the Pentagon's military analyst program.
Episode 5 podcast
Sunday, July 20, 2008
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Hotels in Spremberg, Germany
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Spremberg overviewDon't miss your chance to see attractions like Lausitzhalle and Hoyerswerda Zoo. Spremberg is an inviting destination that has something for everyone.
Where to stay in SprembergWhether you're planning to stay for a night or for the week, the area around Spremberg has accommodations to fit every need. Search for hotels in Spremberg with Hotels.com by checking our online map. Our maps display the areas and neighborhoods around all Spremberg hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Spremberg hotel deals are here with our lowest price guarantee.
How to get to SprembergFly in to Berlin (SXF-Schoenefeld), 66.4 mi (106.9 km) from downtown Spremberg. Berlin (TXL-Tegel) is the next closest major airport, 80.8 mi (130 km) away.
What to see around SprembergHere are some local highlights:
- • Lausitzhalle
- • Hoyerswerda Zoo
- • Konrad Zuse Computer Museum
- • Hoyerswerda Castle Museum
- • Konrad Zuse Computermuseum
When to visit SprembergIf you're still deciding when to visit, here are the seasonal norms to help you plan:
Seasonal temperature averages
- January-March: 53°F day, 36°F night
- April-June: 76°F day, 43°F night
- July-September: 79°F day, 50°F night
- October-December: 59°F day, 37°F night
- January-March: 4.84 inches
- April-June: 7.28 inches
- July-September: 8.62 inches
- October-December: 5.51 inches


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New American Perspective was founded to cut through the clutter in the world of punditry and establish a place where a real conversation could take place between people who disagree, but agree that talking to each other candidly about the candidates and the issues is indispensable to democracy.
NAP covers issues pertaining to electoral politics, foreign policy, culture, academia, economics, and more. Questions and submissions should be directed to editor-in-chief Alex Knepper at firstname.lastname@example.com.


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Images of Bordo
Use the navigation on the right of the window to display the photo series. With one click on a picture you get the larger version. The next pictures will be shown if you move the mouse right or left withiin the image an click on "next" or "back".


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Sometimes it really is hard to find good help. As far as I'm concerned having your skull cap resting outside of your head is no excuse for lying down on the job. Get back up and finish painting that ceiling.
Anyone for a head cheese sandwich??
first bitches...... photoshop !!!
dammit !!!!
Great camera work
Dammit and I knew better than to click on this site while eating lunch ...Oh well on to the next video.
ala carte buffet?
lol, im eating lunch too
^^^not anymore.
why can't they take decent fuckin pictures
HOLY SHIT!How many bears attacked him?
this guy just lets his thoughts pour out all the time
Going to the pub realy takes it out of you.
Have you lost your fucking mind??? oh yeah, I guess you did.
first bitches...... photoshop !!!
imstupid...your a fucking idiot...photoshop, WTF
ya know i really used to enjoy this site. You guys sit on your computers and joke and laugh about real people that die in the most fucked up ways. Innocent people being shot in the head just doesn't seem that funny to me. You guys should only hope that you or someone you love doesn't end up on a site like this only to be made fun of in your last moment on earth. I'm 22 years old. I think a lot of you need to mature or grow a heart. Think of this message in your last moments of life and maybe you'll realize how precious life really is. One last thing, all that I'm "first" bullshit, DAMN thats gay....................
if I ever wind up on this site because of a horrific accident or an elaborate suicide, you'll all laugh at me right???
Your 22 & have a dildo in your ass, life is precious but fuck it while im still alive i still say you have a dildo in your ass.
Oh & on my death bed i dont think ile be thinking that bloke with the dildo in his ass that posted on cshit was right, ide be thinking oh fuck im dieing.
But busanut you semi-literate half-breed, the world will be a better place when you and your sub human ilk here are tippexed by God off the planet for good.


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Goldman Eyes Its Buffett Tab
Wall Street Firm Would Take Care of Its $5 Billion IOU to Warren Buffett
Goldman Sachs Group Inc. is considering paying back a $5 billion investment from Warren Buffett's Berkshire Hathaway Inc. that bolstered the securities firm during the worst of the financial crisis, according to people familiar with the situation.
Goldman announced Berkshire's cash investment in September 2008, a vote of confidence that helped Goldman raise an additional $5 billion the next day despite the chaos that was sinking shares of financial firms. Goldman has the option to redeem the preferred shares held by Berkshire...


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For some people helping us financially is their chosen option. They may be too busy to come to the kennels or help out at an event and so this is their way of giving something back to the greyhounds.
Donations can be made in many different ways. Via our website using pay-pal or just giving (or just text giving) by cheque, by setting up a standing order, or in cash here at the kennels. Every penny counts so whatever you are able to give is really appreciated and it soon mounts up.
For a really painless way of parting with your hard earned money how about shopping using easy-fundraising? You can each make donations to WGW while making purchases on line – and now here's the good news – it doesn't cost a penny. The cost / donation is made by the retailer. You can shop with over 2,000 well known stores and each will donate up to 15% of what you spend. For example, John Lewis will donate 2.5%, Amazon 2.5%, The Body Shop 10%, some insurance retailers will even donate up to £30 simply for taking out a policy with them! Read the guide here.
Or why not sponsor a sanctuary hound? It makes an ideal gift. Sponsorship starts from as little as £25 per year and this cost can be spread by setting up a standing order.
WGW is now registered on Ebay—so why not have a good clear out and donate the proceeds to WGW? Find out more here.
Don't forget to fill in a gift aid form if you are a UK taxpayer as WGW can claim back 25p in the £. We have forms here at the kennels and also on our website.
Donations in Kind
We have drawn up a list of items we really need for the hounds and the kennels, which we have to buy ourselves as day-to-day essentials, but which we could really use your help with from time to time. So if and when you could possibly donate any of the following we would be very grateful.
- Dog Biscuits and Treats
- Packets of Pasta (dried or fresh)
- Tins of Tuna / Sardines /Pilchards)
- Tins of Dog Food
- Packs (or Tins) of Cooked Meats e.g.Corned Beef /Ham/ Spam/ Chicken Roll
- Minced beef or chicken (frozen or fresh)
- Toilet Rolls
- Zoflora Concentrated Disinfectant (or similar)
- Washing Up Liquid, Baby Lotion and Hand Soap
- Tea bags
- Tins of White Paint (unopened please!) – Emulsion / Gloss / Masonry
- Paintbrushes
- Books of Stamps
Please if you have anything you would like to donate, and aren't sure, then give us a call first. And please, don't be offended if we say no.
Walking the greyhounds
As and when you can, no need to make a regular commitment . We are open every day between 11am—2pm. Ask at the kennels or use the Contact Us page for more details.
Helping out at an event
Be it a meet and greet, an event here at the kennels, or an organised dog walk. News of upcoming events is published in our newsletters, on our Events Page and at the kennels. Keep an eye on what's happening and contact the event organiser to see if you can help. There are some events where we have to limit the number or greyhounds and helpers, or because of the nature of the event we have to be very specific about which greyhounds are suitable. So please don't be offended if we decline your offer of help for a particular event.
Offering your services
Do you have a skill, a trade, or an area of expertise that we can use? Or do you have contacts or connections related to your business who, one day, may be the very person we are looking for to supply us with a product/service? Don't be bashful, put your name on our register so that we can find you if we need to.
Manual Labour
Yes folks, every now and then we do need an extra pair of hands at the kennels to help with cleaning, tidying and painting. So if you're up for a day of hard work and don't mind what you do then get yourself booked in for a day at the kennels. We are always looking for extra help during March/April when we give the kennels a spring clean and a new coat of paint in preparation for our birthday celebrations. It's hard work but very satisfying to see the kennels looking their best.
Helping from afar
Why not organise your own fundraising/promotional event? It can be something as simple as a coffee morning, a car boot sale, or a social outing with friends or work colleagues, a collection box at work, a dressing down day, or a stall at a local fair. If you're handy with your hands and enjoy making things why not make something that can be sold to help the hounds? Contact WGW who can discuss your idea, give you any promotional material you need, and advertise the event on their website or at the kennels.
As always, thank you for your kindness and generosity,


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The American Humanist Association advocates progressive values and equality for humanists, atheists and freethinkers in the United States. We work to promote humanism--the idea that you can be good without a god.
Website: http://www.americanhumanist.org
Location: Washington, DC
Members: 784
Latest Activity: Jun 10
Humanist Press is the publishing house of the American Humanist Association, providing material for the humanist/freethought/atheist market since 1995.
With the largest print book seller in the United States now selling more ebooks than paper books, it was time the freethought movement invested in the future of publishing so that we can remain relevant and accessible to readers in the U.S. and around the globe.
With new ebooks becoming available on a bi-monthly basis, Humanist Press will have a regularly expanding catalog of interest to atheist and agnostic humanists everywhere. Visit HumanistPress.com
Darwin Day is a global celebration of science and reason held on or around Feb. 12, the birthday anniversary of evolutionary biologist Charles Darwin.
On this website you can find all sorts of information about Charles Darwin and the International Darwin Day Foundation. If you are hosting a Darwin Day event, you can post information about it on our events listing. You can also locate Darwin Day programs near you by searching our events section.
Let Humanism Ring! The American Humanist Association is pleased to announce that its 73rd Annual Conference will be held June 5-8, 2014 in Philadelphia, Pennsylvania.
Join hundreds of humanists, atheists and freethinkers in Philadelphia for a four-day celebration of humanism! The American Humanist Association will feature informative lectures, book signings, celebrity guests, networking opportunities, child care, fun activities and more!
Book your room early by calling the Sheraton Philadelphia Downtown Hotel at 1-800-325-3535 (mention the American Humanist Association) or visit the AHA's Personalized Reservation Page to get the special rate of $169 per night (subject to taxes). Rates increase after May 5, 2014 so reserve now!
More information will be announced soon!
Started by Chris Brockman. Last reply by Don Feb 28, 2015. 5 Replies 1 Like
Started by Joan Denoo. Last reply by Deidre Oct 7, 2014. 11 Replies 2 Likes
Started by Vulpes. Last reply by Joan Denoo Feb 4, 2013. 3 Replies 0 Likes
Tony Carroll, great cartoon.
@Gary, I owe you an apology on at least two counts. One, I used the wrong name for you and am really sorry that I had forgotten that you use Gary. I could have looked back to old posts and realized my error, however, I was sure I remembered correctly.
Two, I misinterpreted the statement as being yours. That is why I felt confused and needed clarification; it did not sound like you and now I understand why. I wonder if someone else reading it, who did not know you, could misinterpret your meaning? It would be helpful to use quote marks when sharing others' words; that would eliminate misunderstanding.
When anyone writes something that seems out of character, I ask for clarity, and thankfully I did ask you. Your words always hold insights and wisdom and I value your contributions, I always read what you offer, and feel enriched. Thanks Gary.
Thanks, Steph. Seemed apropos to the discussion here. Got off early today. How are you doing?
Right, once we lower the taxes on the wealthy some more, they'll go right out and use the money to higher more domestic help for that THIRD home they just bought...real estate being so depressed right now...those guys are getting some great investment deals, I'm sure.
Mojo, What's a matta with Trickle Down theory? Gotta think, ya know. If rich people pay less taxes, that means they'll have more money two hire mades, cooks, chauffeurs and don't forget illegal Mexicans to mow the lawn. Their people two, ya know?
Paul Ryan is a fine Catholic boy of Irish dissent. He's a regula human bean. One of the boyz, in utta words. That line of yores, "If you feed the horse enough oats, some will pass through the road to the sparrows".. makes me laff. Most feed bags are made out of ledder and don't have any wholes. You gotta think of these tings.
Paul Ryan lives in the same town I live in Wisconsin. On 'Meet the Press' yesterday I kept hearing the phrase "leadership and courage" applied to Romney's 'game-changing' pick for vice president. I also was amused when it was suggested that now "tough serious debates" can begin. There may be an appeal to the tea partiers out there but I cannot see how people can side with the Ryan Plan for our economic future...if Mitt decides to adopt it (calling it HIS plan, I'm sure, modifying it at the edges). From what I know about Paul Ryan, he is a supply-sider...supporting a return to trickle-down theory. "God helps them who help themselves" coupled with "wealthy people are generous with job creation...so keep their taxes really low and don't even touch their capital gains on investments, thank you very much". Like we can count on the wealthy to throw the rest of us a bone once in awhile. This economic plan doesn't work...hasn't worked in the past and won't work now. Tax cuts to the wealthy have not caused some sort of generosity to sprout on a collective level. Increased economic inequality has resulted instead. Like the "horse and sparrow theory" states: "If you feed the horse enough oats, some will pass through the road to the sparrows"...but not much and not when the horse is willing to reclaim what's been dumped and hoard it for himself for later!
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Destined by design
Posted on 19 September 2017 - 11:23am
YEW Kai Leong had always wanted to be a chef since he was a kid, but things took a turn as he studied interior architecture and design instead; a decision that augured well for the 26-year-old.
More well-known as Viinc Yew, he founded his own firm, Viinc Studio Sdn Bhd and is also currently a full-time lecturer at The One Academy. Among his greatest accomplishments include winning "Malaysia Top 10 Outstanding Creative Youth Award" in 2016 and being commended by the Hertfordshire Architecture Association of UK.
"I was a naughty kid. I always got penalised and was nearly expelled from school, but I am lucky to have mentors who influenced me to be who I am today. I believe none of my friends and family would have thought I could be a lecturer today," he mused.
But how does an interior architect differ from an interior designer? Yew explained that an interior architect can design the interior space as well as the building, while an interior designer plans and designs interior space in a built environment.
He said he loves interior architecture and design as he believes the environment and the cosiness of a space can affect anyone in it.
"A comfortable space can help its users whether it is for work, play or rest to achieve better experience and results. I am excited I am the one who makes this 'magic' happen," he said.
At which point in life did you begin to have an interest in interior architecture?
After graduating from high school, my mum didn't want me to be a chef and so, I was wondering what major I should take. At that time, we were renovating our new house and I got to design my own bedroom; that was how I got into it. I found that it is really fun when I am able to make something different to enhance the space.
Where do you draw inspiration and ideas for your work?
By travelling and reading. I love reading design-related magazines and books, and studying the latest design trends and technologies available. I travel to explore different cultures and lifestyles, and learn details that are designed to fit different needs and make life easier. As an interior architect, I have to design space that can enhance my clients' experience, besides making it beautiful.
What's the biggest challenge you face in your work?
The biggest challenge is having to solve different problems for different people due to different preferences and different methods. Each design cannot be repeated because they are all tailor-made to specific clients.
How do you ensure your designs would appeal to your clients?
By understanding that interior design is not only about creating beautiful spaces, it's more about problem-solving with creative and beautiful ideas. Before I get started with a design, I always communicate with my clients to understand their daily lifestyle, habits, needs, preferences and problems encountered.
Give us some tips on interior design.
If you're renovating a house or commercial space and you're looking for a designer, the most important factor is picking a suitable designer. There are many designers out there and all of them have different strengths. Get one who speaks the same language, one who knows what you want and have the similar perspectives as you do.
If you are doing it on your own, a nice set of curtains is really important for the house while for commercial spaces, the right mood is crucial to match the products you are selling.
Tell us about the project you're currently working on.
My team and I are currently developing a few mid-century bungalows into luxurious Nordic homes. It's really interesting to play around with old-meets-new materials. We're also developing a new furniture brand to be launched in Vietnam by year-end.
What kind of places do you usually travel to?
I don't really like tourist spots so I usually ask the locals for recommendations. I research before travelling, from social media to travel guides, to find interesting places to go. I love walking the streets or alleys because that is the best way to experience like a local and learn the culture.
Do you still cook?
Yes, about three to four times a week. I like to try out different recipes. I like a clean diet and I like to make workout meals delicious.


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Heat the oil in a large pan and brown the Lamb then transfer to a casserole dish. In the same pan gently cook the onion, carrot and celery until tender and lightly browned, add 3 cloves of garlic and cook for approximately 1 minute before adding this to the casserole dish. Add the flageolet beans and the bouquet garni, tip any excess fat from the pan and add the water, stirring to combine the meat's residue, pour this over the Lamb and season with pepper. Transfer this to the oven, preheated at 170ºC/325ºF/Gas 3, for 1-1½ hours or until the beans are tender but not starting to disintegrate. Stir in the tomatoes, tomato puree, chilli and sugar and season with salt. (The tomatoes and salt prevent the beans from softening which is why they are not added earlier. Added at this juncture should prevent the beans from disintegrating.)
Return the casserole to the oven and continue to cook for a further 1-2 hours, stirring occasionally, until the meat is so tender it falls of the bone. Remove the chilli, take a couple of ladlefuls of the beans and juices and blend in a food processor until smooth. Stir this into the casserole to make a sauce, taste and adjust the seasoning as required.
To make the gremolata garnish, mix the lemon zest, remaining garlic, and parsley together and finely chop the mixture. Sprinkle this over the casserole to serve.
Serve with crusty bread
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11 of the sweetest fruit bowls
Bright, colourful and shapely, fruit is a pleasure of life that deserves to be shown off, so make sure you choose a bowl worthy of its tempting bounty
Large wooden bowl by Chris Helliwell
£35, National Trust Shop
0300 123 2025; shop.nationaltrust.org.uk
Walker & Tolhurst bowl, dated 1894
£4,500, The Peartree Collection
020 8731 8023; thepeartreecollection.com
Similar to a vase of flowers, a heap of fresh fruit in an eye-catching bowl adds a finishing touch to a kitchen or dining room that can't fail to put a smile on your face. Fruit, in its many shapes, sizes and textures, not only offers a mouth-watering morsel, but is also colourful and cheerful to behold. Artists have appreciated this for centuries, putting the fruit bowl at the centre of many a still life. Italian master Caravaggio, for instance, found nothing more pleasing to depict than a receptacle overflowing with apples, pears, figs, grapes and pomegranates, as shown in his c1599 painting Basket of Fruit. While French impressionist Paul Cézanne was another artist who dedicated many of his artworks to lush, fresh, fruit. Picasso, Matisse and Braque all emulated his example. With this in mind, why not follow suit and bring a striking touch of colour and art to your table with one of these beautiful bowls...
This feature first appeared in the May 2017 issue of Homes & Antiques. Back issues are still available. To purchase a copy click here.


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Lago Vista, TX 78645
Amazing views of Lake Travis & house backs to Highland Lake Golf Course. Huge 100+ year old oak tree nestles against back porch. Stone/stucco exterior with accent siding. Custom designed for lot to take in the views- large windows. Gorgeous Cortec Plus flooring throughout kitchen and living (kid proof, pet proof and water proof-looks like wood!). Glass tile splash and granite counters. Master suite: large corner tub, double vanities, walk-in shower. Energy Efficient upgraded spray foam insulation & HVAC.
Courtney Kirk with Century 21 Hellmann Stribling
2018 Baronet Realty. All rights reserved. © Collaborative Home Search by RealSavvy
Based on information from the Austin Board of REALTORS® for the period through [see date below]. All listing information is deemed reliable but is not guaranteed and should be independently verified. The Austin Board of REALTORS®, ACTRIS and their affiliates provide the MLS and all content therein "AS IS" and without any warranty, express or implied. Listing information is provided exclusively for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing


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At ceremonies held in Lexington on Friday to remember an estimated 4,400 patients at Eastern State Hospital who were buried on the mental hospital's grounds years ago, 4,400 small cards fashioned into a necklace represented 4,400 apologies for what some people say was a disregard for the bodies.
"It's recognizing an injustice that was done to those who were buried in the cemetery, and that is specifically the fact that many people there have been reburied at least three times, ashes are mixed and it is essentially a mass grave," said Bruce Burris, co-owner of Latitude Artist Community, which led the events.
"We're not blaming anyone for that. We are just acknowledging it," Burris said.
According to its blog, Latitude Artist Community serves all people, but especially "those thought by some to have a disability," by creating inclusive community interactions.
A cemetery remains at Eastern State. The hospital housed more than 2,000 patients at its peak in the 1940.
Eastern State, at West Fourth Street and Newtown Pike, began admitting patients in 1824, and about 4,400 residents are thought to have been buried on the grounds. The burials occurred over more than 100 years.
Over the past few weeks, Latitude artists worked to create 4,400 small cards, each bearing an artist's thumbprint. The cards were strung to resemble a necklace, Burris said.
At Eastern State Hospital Cemetery and the Lexington Public Library courtyard downtown Friday, Erin Fitzgerald silently counted and acknowledged each card on the necklace.
Burris estimated that a total of 50 people attended the two events.
Fitzgerald said she wasn't expecting a big audience.
"The important thing is that the ritual be done, and that it be reverent and meaningful," she said.
Eastern State agreed in 2008 to move from Newtown Pike to a new complex at the University of Kentucky's Coldstream Research campus. Under the agreement, BCTC will move from UK's campus on Cooper Drive to Eastern State's location. The hospital has not yet moved to its new home.


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A mixture of puppet and hand-drawn animation, The Necktie is the story of Valentin and his quest to find meaning in his life. Stuck in a dead-end job, he has forgotten all about the things that used to bring him joy. Years pass, and boredom replaces all his aspirations and hope for the future. It is only on his 40th birthday, when he rediscovers an old accordion hidden in the depths of his closet, that he regains his lust for life.
The Necktie is a critical look at the apparently immutable powers-that-be, the dehumanizing nature of futile work, and hope reborn after all.
Watch The Necktie - The Animated Short Film
National Film Board of Canada official web site The Necktie
The following is taken from Wikipedia.org - the free Encyclopedia of the Internet
The Necktie (French: ''Le noeud cravate'') is a 2008 animated short by Jean-François Lévesque about a man with a dreary job who rediscovers his old accordion at age 40, and with it, his joy for life.[1]
The film uses a variety of animation techniques. The central character is a puppet filmed in stop-motion, inside miniature sets. His co-workers are animated with traditional animation drawings on paper, digitally integrated into shots but designed to give the appearance of being 2D cardboard cutouts.[1] The Necktie was produced in Montreal by the National Film Board of Canada.
The film garnered the Jutra Award for best animation, the Fabrizio Bellochio Prize for Social Content at the I Castelli Animati Festival as well as the Best Short Film Award and the Audience Prize for Best Canadian Short Film at the Montreal World Film Festival.[2][3]
Originally from Saint-Gabriel, Quebec, Lévesque lives and works principally in Montreal. As a child, he had participated in animation workshops in the Carrousel international du film de Rimouski children's film festival; in 2009, he was named its honorary co-president.[3]
read more at wikipedia.org/wiki - The Necktie


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Bergamot Station is the historical name for the site on which the gallery complex is located, dating back to 1875 when it was a stop for the Red Line trolley running from Los Angeles to the Santa Monica Pier. Bergamot is a flower of the mint family that once flourished in the area. Bergamot Station is formeb by more than 30 art galleries.
Since its restructuring, Bergamot Station has become a popular destination for visitors from around the country and the world. Bergamot Station provides a central location which allows visitors to park in one place and spend the day seeing art, rather than spending time driving from one gallery to the next. It now appears in every guide to Los Angeles as a primary cultural destination, with well over 600,000 visitors each year.
Technarte will be held in the second largest gallery space in the complex, The Writer's Boot Camp (2525 Michigan Avenue, Building I
Santa Monica, CA 90404). Located within the distinguished art community of Bergamot Station in Santa Monica, Writers Boot Camp's will accommodate the first edition of Technarte in Los Angeles.
Located in Santa Monica, a beachfront city in western Los Angeles home to many Hollywood celebrities and executives and is a mixture of affluent single-family neighborhoods, renters, surfers, professionals, and students. More than 7 million visitors a year come to Santa Monica because it is a renowned beach city (one of National Geographic's top ten), close to other Los Angeles attractions and easy to get around.
We would like to make easier your arrival and stay in Los Angeles. Hereby some points of interest related to Technarte and to the city.
[widgets_on_pages id="dos"]


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An influential American Congressman has said there is a need to bring India into a regional alliance with Pakistan, given that Islamabad is not able to come out with its cold-war mentality, as it still considers New Delhi as a primary adversary.
"We have to do more to bring India into a regional alliance or at least some ad hoc coalition with Pakistan," Member of the US House of Representatives Joe Sestak told MSNBC in an interview on Tuesday.
"Pakistan has been primarily focused on India. It still thinks India is its -- like the Soviet Union was to us -- still cold-war adversary," he said.
Such a statement from the senior Democratic Senator came amidst media reports that US President Barack Obama has offered Pakistan help to reduce tensions between the country and India.
India has traditionally opposed any third party mediation, which has been respected by the Obama Administration.
Both Obama and Secretary of State Hillary Clinton have said it is up to India and Pakistan to resolve their disputes through bilateral dialogue.
At the same time, they have maintained that the US would encourage the two South Asian neighbours to do so.
Congressman Sestak also supported the idea of giving access to Drones to Pakistan.
"We understand that their intelligence is very involved with some of these terrorist groups. They sent them up into Afghanistan to go after the Soviet Union and others. But we have to be able to trust them," he said.
"For example, we actually have our Predators, our drones, where we pull the trigger and actually kill someone of the Al Qaeda on the other side of the border.
And if we were to give them the ability to pull the trigger, that takes away the onus from us and places it upon their own troops going after the Al Qaeda."
"We just have to leave behind conditions that are inhospitable to some degree for the Al Qaeda to come back. This is about Pakistan," Sestak said.
"This whole strategy has only one objective, and I hope the president makes that very clear tomorrow night. That's the eradication of the Al Qaeda's safe haven in Pakistan.
This is really a Pakistan strategy, Pakistan a nation that's almost a failed state, a failed state with nuclear weapons," he said.The US representative also said he had earlier talked to former Pakistani President Pervez Musharraf about a month or two ago.


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To all your valued members please be advised that membership fees for 2017 are now due. These can be paid at the station at 44A Lovell St Young between 9 am and 4 pm weekdays.
Alternatively you can do a direct debit into our bank at the South West Slopes Credit Union being :
Account name: Lambing Flat Community Broadcasting Inc
Account: 14301
N.B Please include your Name and Membership number in the description.
The fees for this year are:
Normal Fees :$15.00
Pensioner : $10.00
Clubs: $30.00
We thank all our members who have already renewed and wish to encourage any new members to sign up and be a part of your local community radio 2YYY.
Thanking You
Tony Gentle
Acting President


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Words containing phidiscophor
Found 1 words containing phidiscophor. Browse our Scrabble Word Finder, Words With Friends cheat dictionary, and WordHub word solver to find words that contain phidiscophor. Or use our Unscramble word solver to find your best possible play!
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For most people, the hardest part of lasting weight loss is either getting started or reaching their goals--too often, motivation is tough to maintain or those final few pounds simply won't budge, no matter how many hours are logged on the treadmill and how many calories counted. Now, from the New York Times bestselling author of The Body Reset Diet, comes a deceptively simple plan to slim down--whether you to need to shed those last few stubborn pounds or want to jump start a more significant weight-loss effort. 5 Pounds teaches readers how to implement five simple strategies as daily habits: ac Walk 5 miles a day. ac Eat protein and fiber 5 times a day. ac Do resistance exercise 5 minutes a day. ac Sleep at least 7 hours a night. ac Unplug at least 1 hour a day. Readers will enjoy immediate results--dropping 5 pounds or more in just 5 days--and boost energy, improve overall health, and finally achieve long-term weight-loss success. With step-by-step advice, easy-to-prepare recipes, and motivating success stories, 5 Pounds will transform the way readers look and feel forever.With step-by-step advice, easy-to-prepare recipes, and motivating success stories, 5 Pounds will transform the way readers look and feel forever.
|5 Pounds
|Harley Pasternak
|Rodale - 2015-03-03
You must register with us as either a Registered User before you can Download this Book. You'll be greeted by a simple sign-up page.
Once you have finished the sign-up process, you will be redirected to your download Book page.How it works:


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Software Developer
Hello, my name Phong Huynh. I am a developer.a learner.a blogger.a guitar player.an avid reader.a gamera gym rat.a super saiyan.
I am passionate about clean code, minimal design, and learning new things.
I believe in positivity and making the best from failures/mistakes.
Check out my open source projects
I currently work for Hubba. Using a modern stack with an intelligent process, I am building out Hubba's web application and platform, testing all code and measuring as features are delivered.
I built web solutions in an agile team environment for Architech's various clients.
I developed user interface components and implemented new features for ScribbleLive's Pro and Enterprise products.
I built websites and web applications for Dashboard's various clients.
I studied Web Development and I have a Postgraduate Certificate with Honours at Humber College Institute of Technology and Advanced Learning.
I have a diploma with Honours in Computer Programming at Humber College Institute of Technology and Advanced learning.
Visit my Blog


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The U.S. economy is soaring, consumer confidence is strong and the dollar is holding steady against European currencies.
It looks like a good time to go to Europe.
But travelers planning summer vacations may be in for sticker shock when they start hunting for air fares to Europe.
Call it a case of supply and demand.


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An Honors Seminar is a 3000/4000 level dedicated Honors course designed for Honors students. Enrollment in the class is typically between eight and 19 students.
Honors Seminars are engaging, discussion-based courses where students will apply critical thinking skills and obtain feedback on their written, verbal, and/or digital communications.
Each seminar is accessible and available to all majors across campus. This creates a classroom environment where interdisciplinary discussion, thought, and perspective are not only sought, but they are encouraged.
All Honors College students must take at least one honors seminar to satisfy the H6.
All Honors Seminars have a 301, 302, 303, etc., section number and can satisfy the H3, H4, H5, or H6 Honors Course Requirements.


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The Heart is the Capital of the Mind --
The Mind is a single State --
The Heart and the Mind together make
A single Continent --
One -- is the Population --
Numerous enough --
This ecstatic Nation
Seek -- it is Yourself.
Poet: Emily Dickinson
Poem: 1354.
The Heart is the Capital of the Mind --
Volume: Complete Poems of Emily Dickinson
Year: Published/Written in 1955
Poem of the Day:
Jun 25 2017
Are you looking for more information on this poem? Perhaps you are trying to analyze it? The poem, The Heart is the Capital of the Mind --, has received 29 comments. Click here to read them, and perhaps post a comment of your own.
More Poems
(1775 poems)
Emily Dickinson books


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Optimus Cards Group offers a full end-to-end white label debit card service.
Imagine implementing a full debit card solution linked directly to your members' accounts in as little as two months without having to invest in specialised staff, expertise or infrastructure. Now, for the first time, you can.
We handle everything, from card design, card ordering and PCI compliance through to settlement, fraud transaction monitoring and 24x7x365 call centre operations.


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Want Jimmy to answer your question? Like his Facebook fanpage and post the questions
Jimmy consults with top athletes from various organizations, why not inquire how he can help you and your health? Click here now
With the recent trend to stay away from artificial sweeteners, there's more and more confusion being spread around about the "healthy" alternatives like stevie, and more recently, xylitol. But what is xylitol and is it really an alternative to artificial sweeteners?
While some food labels classify xylitol as a carbohydrate, it's far from it. Xylitol sweeteners are technically a Polyol. While not an actual sugar, it can for all intents and purposes, be considered one. It can be converted to a monosaccharide class of sugar as well as ketoses( carbohydrates that contain ketone groups).
What's It Found In?
Well for starters, you! That's right, we can make up as much as 15 grams of xylitol per day depending on the food we eat. The best external sources are berries(especially raspberries), lettuce and mushrooms. Since it's found in such small quantities, it can not be pulled from these foods. One of the major manufacturing sources being birch tree scraps.
What You Can Get Out Of It
Well for starters, xylitol sweeteners are excellent for your teeth. I just felt the need to put that out there. Since you're primarily interested in the physique aspect of it. During times of extreme stress (when you're trying to lose fat or get rid of stomach fat) xylitol can be used as alternative energy source as well as aid in stabilizing your blood sugar.
The best thing about xylitol(aside from its taste) is that it can activate the glutathonie pathway in the body. Glutathonie is one of the bodies most powerful antioxidants. Red blood cells take up xylitol quickly and quench free radical damage.
Another interesting note is how unabsorbed xylitol acts in the body. It actually acts as a fiber that then produces violatile short-chain fatty acids, thus it can act as a longer-lasting energy source.
What About The Taste?
Since xylitol so closely resembles table sugar, it can be used to replace artifical sweeteners like sucarlose and aspartme. You can actually almost feel it "melting" in the mouth because it dissolves so quickly. Seriously, try some xylitol as your sweetener next time you need to change things up on a low carb diet.
Tags: Alternate Energy, Alternative Energy Source, Artifical Sweeteners, Artificial Sweeteners, Aspart, Birch Tree, Carbohydrate, Chain Fatty Acids, Energy Source, External Sources, Extreme Stress, Facebook, Food Labels, Free Radical Damage, Healthy Alternatives, Intents And Purposes, Lasting Energy, Lettuce, Mushrooms, Polyol, Red Blood Cells, Short Chain Fatty Acids, Sweetener, Table Sugar, Xylitol Gum, Xylitol Side Effects, Xylitol Sugar, Xylitol Sweetener, Xylitol Sweetner


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Samatha wanted nothing more than to be dead. When she...
My Poems
- by Bandgeek102016
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- Published: 19 Aug 2014
- Updated: 26 Mar 2015
- Status: In Progress
This is my poems my deep dark though....
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inline filter box 500mm with G4 Filter media
Brand: Ducting Express
Product Code: inline filter box 500 mm G4
Availability: In Stock
Weight: 4.00 kg
Size in MM: 600 x 150 x 600
Product Code: inline filter box 500 mm G4
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Price: £98.50
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Inline Filter box 600mm x 600mm with 500 diameter spiggotts and disposable 600 x 600 x 45mm G4 filter media
- For air filtration in ventilation and airconditioning systems
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- Galvanized steel plenumbox with easy accessible top cover
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- Dry Skin
- Sinus Congestion
- Dry Throat
- Nose Irritation
- Bloody Noses
- Dry Cough
- Cracked Lips
Babies have sensitive skin and even more sensitive respiratory systems. During the winter time, when central heaters are turned on and indoor humidity drops to 10 percent or less, the dry air can irritate a baby's skin, nose, and lungs. This cold, dry air also helps viruses to grow. Furthermore, when babies come down with a cold or respiratory infection, they cannot take the same over-the-counter drugs that an older child or an adult can; their small bodies are too fragile for strong medicines.


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Travel Set Welcome Box
THE THREE GREAT MINIS – a little of this and a little of that for a whole lot of beautiful, well-conditioned hair
Perfect for travel, three great Dual-Active minis in a practical case. Includes: Daily Moisture Shampoo, Conditioner 60 Sec. and Protector Instant Care Spray.
Each 50ml


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4001AD #2 (Cover D Tan)
The most ambitious comics event of 2016 brings war to the 41st century - with Rai leading the charge!
- More Below…
Product Description
- Artist
- Clayton Crain
- Author
- Matt Kindt
- Binding
- Comic
- Cat No.
- 3610152
- 85899200336900241
- Genre
- Fantasy
- Previews
- Previews April 2016
- Publisher
- Valiant Entertainment
- Type
- Comics
- Volume
- 40012
- Wednesday Comics
- Wednesday Comics (On Thursday) 02/06/2016
The most ambitious comics event of 2016 brings war to the 41st century - with Rai leading the charge!
Rai is smashing headfirst into New Japan with his team of hardened rebels - including the Eternal Warrior and a giant X-O Manowar mecha-armor that's been dormant for centuries! But when Father transforms New Japan into a impenetrable space dragon as a defense of last resort, what hopes will the united heroes of 4001 A.D. have of freeing the citizens of New Japan from Father's brutal reign? Will Rai have to destroy New Japanto save it? New York Times best-selling writer Matt Kindt (DIVINITY II) and superstar artist Clayton Crain (X-Force) bring their starling vision of the year 4001 A.D. to new heightswith the fate of New Japan floating in the balance!
Customer Reviews
There aren't any reviews published for this product yet, why not be the first to write one?Write your own review.


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|27 Jan 2013
fireberd many thanks again... but i finally give up . For some reason only the driver takes... and the interface remains the same. Or says that there's no audio device...
|My System Specs
|27 Jan 2013
Windows 10 64 bit
Looks like you are stuck with the basic Intel hardware/software configuration.
There may be some add on that will get you more, but if either the Gigabyte SoundBlaster MB or the ASRock enhancements don't work, I don't know what will.
|My System Specs
|27 Jan 2013
Thanks for all the help! Will try again a bit later. For the interim will just attempt to live with the problem :)
|My System Specs
|Thread Tools
|Similar help and support threads
Realtek audio drivers (intel motherboard) does not work for win 7,
HI, I have audacity for audio recording. I bought a headphone with mike. Intel mother board sound card which i have been using in windows xp, is not working in windows 7. When i Installed win7, it auto detected the HD audio drivers from Microsoft and updated to win 7. There is no...
|Sound & Audio
Realtek High Definition Audio and Intel Display Audio
I think my question is this: how do I set up VSX-1124 (a Pioneer AVR) in Control Panel/Sound and Hardware/Sound so that its driver is Realtek HD Audio and not the Intel Display Audio one? In Device Manager under Sound, Video and game controllers, I have two sound card drivers, Realtek High...
|Sound & Audio
Difference between Realtek HD Audio Manager & Realtek HD Audio Driver
It's been a year since I migrated from Windows XP to Windows 7 which I downloaded Realtek HD Audio Manager R2.70 and audio has been working fine except the only issue it didn't come with 'Stereo Mix' preventing capability to record sound direct from the soundcard. It took me 14 months to restore...
|Sound & Audio
ASUS/Realtek, Latest Realtek versus default W7 Audio driver
I installed the Realtek HD audio driver from the ASUS download site (P8Z68-V Pro MB) and all was well until I installed an MSI 560TI video card and let it install the Nvidia HD Audio drivers. The problem I have been chasing ever since was the Realtek HD Audio Manager popping up after the system...
|Sound & Audio
Realtek HD Audio Manager and Realtek Audio Driver
Help. I recently did a clean install of Windows 7 64bit (on my HP Vista 32 machine). Life is grand! My problems started when I tried to listen to the microphone input through my speakers. The front microphone inputs did not work so I downlaed the Realtek HD Audio Drivers (recently updated) from...
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Eric Olson (b. 1974) is a typeface designer, founder and partner at the Process Type Foundry. He attended the University of Minnesota intermittently, finally earning a degree in Graphic Design after dropping out and re-enrolling as dictated by the ups and downs of touring in a hardcore band. During his studies, he became inspired by Emigre magazine and took up typeface design. Naturally, those early efforts were futile but the process was exhilarating and rewarding. After graduation, he entered the professional world as a graphic designer by day – working at institutions like the Walker Art Center – and by night working as an unpublished type designer. Eventually, after drawing a lot of type and receiving encouragement from his colleagues, he left graphic design to design typefaces part-time while also teaching typography at the Minneapolis College of Art and Design. In 2002 he launched the Process Type Foundry.
After two years of moonlighting as a type designer, he decided to concentrate on work for the Foundry full-time and left his teaching position. This allowed more time to realize typefaces and accept commissions, but most crucially, time for rejecting and editing – the very cornerstone of typeface development. From this sprung families like Klavika, Stratum, and Seravek – solid hard-working typefaces the foundry has become known for.
In recent years, Eric's attention has been focused largely on custom work. A range of commissions including a family of san serifs for The New York Times Magazine and a family for Thomson Reuters with Greek and Cyrillic support have occupied much of his time. Some of these custom typefaces will find their way to public release in 2010 along with other long-overdue releases.
When not in the studio, Eric can be found cycling or thinking about cycling.
Nicole Dotin (b. 1974) is a typeface designer and partner at the Process Type Foundry. She earned a degree in photography from the University of Minnesota while also documenting the exploding mid-90s hardcore scene through a self-published magazine. Publishing made her realize that graphic design was a powerful tool that required further investigation, so she enrolled in the graduate program at the Minneapolis College of Art and Design, emerging with an MFA in Visual Studies. While at MCAD, she was exposed to typeface design, which culminated in the publication of her graduate thesis exploring the nomenclature of font vs. typeface.
Her route to the Process Type Foundry and typeface design was more a process of winnowing than a direct shot – first working as a professional graphic designer, then working part-time for the foundry, becoming focused on detailed typography and later teaching typography at MCAD. At some point in 2006, she overheard students discussing their study-abroad experiences and it was at that moment she decided to apply – successfully – to the type design program at the University of Reading in the UK. Before leaving the States, she initiated the foundry's rural studio experiment which consisted of moving the foundry to a remote region of northern Minnesota for 6 months of work, reflection and swimming after lunch.
While at Reading, Nicole put her past experiences to work in making a typeface for continuous reading. A year later, she emerged with an MA in Typeface Design with distinction and the beginnings of Elena, a serif typeface released five years later in 2011.
When not in the studio, Nicole can be found doing any number of things since her interests tend to be wide: running, problem-solving, sewing, destroying unsuspecting opponents in Pente... you get the idea.
Alice Savoie (b. 1984) is a typeface designer and creator of the Capucine family. Raised in the French countryside, she moved to Paris to study graphic design at the École Duperré where she discovered the intriguing world of typeface design thanks to her teacher's admiration for Zuzana Licko and all things typographical. She then enrolled at the École Estienne in a course focused on typography and typeface design, and was taught the art of drawing letters using a broad nib pen, pencil and some tracing paper.
Feeling like she was just starting to get the hang of it, Alice decided to cross the Channel and attend the MA in Typeface Design at Reading University. After an intense year designing type and writing about French type foundries, she graduated in 2007 with distinction. She worked for a short time as a graphic designer in London before joining Monotype in 2008 as a full-time type designer. Her role there primarily involved custom type design as well as new additions to the library – including Latin, Greek, Cyrillic, and Hebrew typefaces. Since 2010 she works as an independent type designer and font developer, collaborating with fellow designers and agencies on custom projects and large retail type families. In 2014 she also completed her PhD at the University of Reading on the design of typefaces during the phototypesetting era. She currently lives and works in Germany.
When not in the studio, Alice can be found in a train travelling between two European cities, at the gym enjoying a Pilates class, or at home trying to get the hang of German grammar.


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County's Best Young Entrepreneurs win €50,000 Investment
Three of the county's best young entrepreneurs have won a total investment of €50,000 through the Local Enterprise Office Wicklow, as part of the €2 million Ireland's Best Young Entrepreneur competition (#IBYE). Aimed at young and aspiring entrepreneurs between the ages of 18 and 30, Ireland's Best Young Entrepreneur competition is an integral part of the Action Plan for Jobs and is supported by the Department of Jobs, Enterprise and Innovation through the network of 31 Local Enterprise Offices.
Read more: County's Best Young Entrepreneurs win €50,000 Investment
Encouraging increase in Enterprise Ireland Jobs in Wicklow
Fine Gael Wicklow TD, Andrew Doyle, has said that new figures show there has been an encouraging increase in the number of jobs in Enterprise Ireland (EI) supported companies over the last two years. The number of jobs in EI companies in Wicklow was up to 3,339 last year, an increase of almost 200 since 2010. Furthermore, the number of jobs in EI companies in the county is now above 2009 levels.
Read more: Encouraging increase in Enterprise Ireland Jobs in Wicklow
€10k Prize For New Business Startup In The South-East
A group of business people from North Wexford/ South Wicklow have organised a Business Expo with a difference to take place on the 24th of February 2011 in the Ashdown Park Hotel, Gorey. The Business Expo will consist of a Trade Show for BNI Falcon members followed by a 'Dragon's Den' style competition for new and aspiring businesses.The prize will be €10,000 worth of services and products from the members of the group.
Read more: €10k Prize For New Business Startup In The South-East
Southeast Business Network Launched
Spontaneous Marketing continues to support the Southeast Business Network, a new networking event for businesses in Wicklow, Wexford, Carlow, Kilkenny, Waterford and Tipperary. Spontaneous Marketing is a sales, marketing and promotions company set up to provide marketing support, event management and consultative services to all types of businesses. The business is run by brothers Ruairi and Kieran Gough who between them have over 20 years industry experience in the USA, UK and Ireland.
Network of Entrepreneurial Women in Wicklow
"N.E.W. (Wicklow)" - the Network of Entrepreneurial Women (Wicklow) is a business support network for female entrepreneurs in County Wicklow. The Network is funded by the Wicklow County Enterprise Board. Members can utilize the network to promote their business, create alliances with other members, learn new skills, and increase their business contacts.


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AA Large Hotel Group of the Year 2012-2013
Hand Picked Hotels, the collection of architecturally splendid country house hotels, has won this prestigious award, which was was announced at a glittering awards ceremony in London. 24th September 2012.
Professional Beauty Awards - Best Employer for over 21 employees – Spa sites
A panel of seven expert judges, based in each geographical area, selected the finalists after a vigorous and unbiased judging process. The final winner was selected for each category following a visit from both an "official" judge and a "mystery" judge.
Sponsored by Lash Perfect Hand Picked Hotels are proud to have won employer of the year. March 2012.
Best Group website award – Caterer.com web awards, handpickedhotels.co.uk.
The websites are judged on criteria including visual design, innovation, content, interactivity, ease of use, commercial success or potential and overall user experience. The judges considered more than 50 entries and Hand Picked Hotels are proud to have won best hotel group website. November 2010.
British Association of Landscape Industries (BALI) awards in the category of Grounds Maintenance – Multiple sites.
Flora-tecs Managing Director Andrew Bradley, and Hand Picked's Property Manager Guy Cherry were presented with one of the three awards in this category, sponsored by the Institute of Groundsmanship. The award citation commented on the impressively high standard of maintenance that was achieved across the board. December 2008.
AA Hotel of the year 2008/2009 Scotland
Norton House Hotel & Spa Edinburgh wins AA hotel of the year 2008/2009 - Scotland.
Excellence in Marketing 2007 - HRS Awards
Hand Picked Hotels won the 'Excellence in Marketing award' at the HRS Hotel Excellence Awards in January 2008.
Best Marketing Campaign on a small budget 2007 - HMA
Hand Picked Hotels won the Hotel Marketing Association prize for ' Best Marketing Campaign on a Small Budget' in December 2007.
Notable Wine List Award 2007 - 2008 (The AA)
Rookery Hall and Wood Hall Hotels have both received the 2007- 2008 Notable Wine List Award from the AA.
More awards:
Julia Hands was chosen as one of the top 10 entrepreneurs in the UK in the National Business Awards 2005.
The top award in the Tourism and Leisure business sector for the First Women Awards, organised by the CBI in conjunction with Real Business magazine in 2005.
Hand Picked Hotels were also one of the top 50 companies to watch in 2005 by Real Business magazine.
AA Hotel Group of the Year 2004 - 2005
The Business Excellence Award presented by the Tourism Minister in 2004


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The Big Agnes Fly Creek HV Platinum 2 Tent is a crazylight tent for minimalist backpackers. Sleep solo with loads of space or have room for a friend to hike along. The mostly mesh tent with bathtub flooring is light, airy and features high volume space. Go ahead, sit up in the morning, stretch, then change your shirt. The single door opens up to a single vestibule (if you're using the fly) for plenty of storage space. Sleep soundly, then break down camp quickly for some more miles on the trail.
So sorry, but only 4 items are allowed for comparison, so we're comparing the first 4. I blame the gnomes and so should you.
Would you like to compare the products you have selected now?


text:
We offer a vision and reflection of shared humanity in the world and use art as a catalyst and call to action to draw audiences into civic dialogue about life to re-imagine the world and build community.
Our work grows out of partnerships with communities and their organizations, including communities of color, refugees, and immigrants, and reflects the lives of women around the globe.
We have produced 13 seasons of concert performances and a range of workshops in the Twin Cities since 2004, and our work has been presented in 16 other U.S. cities and 11 other countries.
We seek to inspire our audiences to join the "citizenry of dancing"—the movement of believing in the arts as civic action.
We have learned that women, in the midst of stories of devastation and horror, often find courage, conjure hope, summon love, and imagine sustainability.
We invite you to support our work with a financial gift.
To donate, click on the image above. Alternatively, you may mail a check to Ananya Dance Theatre, P. O. Box 2427, Minneapolis, MN 55402.
Thank you!


text:
Thanks for helping us sort this video!
Thanks for helping us associate the correct Pornstars to this video!
Ayúdanos: ¿Estas estrellas porno aparecen en este vídeo?
Pornstar Name:
Wow feisty one
What are these people SMELLING? Heaven from her pussy
sorry again not so go in fact boring just a personal but its nice if at least one person sees then it kinda teasing and fun :) :)
Good Idea. Beautiful girl. Anti-climatic.
i want to fuck her damn she,s hot
they are thinking: wow lets fuck gal... on the toilet or do you like to be licked here imediately... hhhmmmmmmm
same here @wut up
she has such a beautiful pussy!
Puedo metertela si quieres nena
i want go with you in the train!!!!
if i was on this train id get my cock out and wank with her lol she stunning
hey wut up, I hear you dude, strangely hypnotic!
She doesn't look like she's enjoying herself in most of her videos, yet I still keep watching lol...
They are thinking: " WOW, oh yeah boy"
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text:
Private Practice Recap: "Crime and Punishment"Steve Marsi at . Comments
Does life begin at conception? Is abortion amoral? Can you kill your chronically ill wife to put her out of her misery and expect to be set free?
These uplifting topics took center stage last night on Private Practice, and you at least have to give the much-maligned Grey's Anatomy spin-off credit for going there. These topics may be taboo, but they sure beat the usual non-witty witty office banter.
Follow the link for a full recap of "Crime and Punishment" ...
Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.


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Incremental Credit Policy
In order to increase sales from their present annual $35million, ABC Company, a retailer, is considering more liberal credit standards. Currently, the firm has an average collection period of 30 days. It believes that with increasingly liberal credit standards, the following will result:
Credit Policy
Increase in sales from previous level (in millions) $5.5 $4.5 $2.3 $1.1
Average Collection period for incremental sales (Days) 45 60 90 150
Bad-debt loses on incremental sales 2% 4% 7% 10%
The prices of its product average $30 per unit, and variable cost average per unit is $25. If the company has a before-tax opportunity cost of 20%, which credit policy should be pursued?© BrainMass Inc. brainmass.com August 18, 2018, 6:12 pm ad1c9bdddf
Solution Summary
Incremental Credit Policy


text:
Power Management for Exascale
|Power Management for Exascale
|Publication Type
|Conference Paper
|Year of Publication
|Iskra, K, Yoshii, K, Gupta, R, Beckman, PH
|Other Numbers
In order to meet the exascale goals, today\'s top high-performance computing (HPC) systems will need to scale by two orders of magnitude, at the same time increasing their power consumption by only an integer factor. Power consumption of both individual nodes and the overall system is thus a critical issue to address.
Most performance studies of large-scale HPC systems and their workloads have focused primarily on flops, bandwidth, and latency. Few concrete studies exist that focus on quantifying power and energy consumption at the hardware and software levels. Until recently, system vendors have had little incentive to expose extensive system and component-level power interfaces to users. Consequently, the power-management methodology is lacking, and the underlying capabilities in today\'s computer systems are limited or missing. Exascale systems, consisting of hundreds of thousands of nodes drawing tens of megawatts of electrical power, mandate a need for new, system-wide methodologies and procedures for power monitoring, management, and scheduling.


text:
Renew Your Dues Online Now!
NSSLHA members are asked to reaffirm their understanding of the pre-professional guidelines when they pay their renewal dues/fees.
By phone at 888-321-ASHA (2742) 8:30 a.m.–5:00 p.m. ET, Monday through FridayPlease have your ID number for faster service.
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You can also join (or renew) your Special Interest Group(s) affiliation at the same time you renew!
Questions? For more information, please visit ASHA's Frequently Asked Questions or contact the Action Center (email@example.com or 800-498-2071).
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The American Speech-Language-Hearing Association (ASHA) is the national professional, scientific, and credentialing association for 198,000 members and affiliates who are audiologists; speech-language pathologists; speech, language, and hearing scientists; audiology and speech-language pathology support personnel; and students.
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1. Do you have any business or financial connections
or other commitments which might give rise to a conflict of interest
in carrying out your duties as a member of the MPC?
2. Are there any relevant personal or other
factors of which the Treasury Committee should be aware in considering
your nomination?
3. Do you intend to
serve out the full term for which you are appointed?
4. Please explain how your experience to date
has equipped you to fulfil your responsibilities as a member of
the MPC.
(1) Much of my career has been spent working in financial
markets. This has given me experience of the way in which monetary
policy decisions are transmitted into market interest rates and
other asset prices and via the banking systemimportant
parts of the monetary transmission mechanism. It has also given
me experience of the ways in which financial markets form expectations
of monetary policy decisions. That is relevant to using financial
market prices as indicators or diagnostics of expectations, which
affect economic behaviour.
(2) I have been involved in various ways
over the past 10 years or so in advising on the formulation and
presentation of monetary policy. I ran one of the Bank's monetary
analysis divisions, which focused principally on questions of
monetary policy strategy/framework and on the monetary and credit
aggregates. Over the past five years, I have been one of the small
team preparing the minutes of MPC meetings, and in earlier roles
I contributed to speeches on monetary policygiving me some
experience of explaining policy.
(3) In my current role, I have experience
of synthesising macroeconomic, financial market and banking system
information with market intelligence, as represented for example
in the Bank's twice yearly Financial Stability Review. The information
relevant to monetary policy overlaps considerably, and the objectives
are closely related.
5. How important do you think it is for MPC
members to be subject to ex post parliamentary accountability?
Could the current procedures be improved?
(1) Very important. MPC members are not democratically
elected but take decisions which affect the people of the country
individually and collectively. It is right that we should be accountable
to the people through the people's elected representatives. For
that accountability to work, the framework and objectives should
be clear, which I believe they are.
(2) So far the current procedures seem to
have worked well. The public debate on monetary policy has improved
considerably compared with a decade ago.
6. If you were to stand for reappointment
to the MPC at the end of your term, what criteria do you believe
should be used to assess your individual record as a MPC member?
(1) First and foremost, the outturns of inflation
relative to the target set by the Government; and the explanations
the Committee has given of its analysis and decisions. The lags
in the effects of monetary policy changes need to be taken into
account: there can be shocks to the economy before the full effect
of earlier policy settings has worked through. So ex post assessment
needs to be based on the information available to Committee members
when making their policy choices.
(2) Secondly, my voting record, coupled
with my record of explaining my analysis and policy choices. If/where
I vote in a minority, the counterfactual path of rates I preferred
would need to be taken into account, which of course is not straightforward.
(3) Third, my record in publicly explaining
the Committee's work, and in listening to input from around the
(4) Fourth, my record as the Executive Director
for the Markets area of the Bank, accountable to the Bank's Court
of Directors; and so in particular the Bank's performance in (i)
the implementation of monetary policy (through open market operations
etc) and (ii) providing analytical and practical input on financial
markets to the Committee's deliberations.
7. Is the framework of an explicit inflation
target the best within which to conduct monetary policy?
It is by far the best framework the UK has had
in recent decades. It has three distinct merits:
8. What consideration should be given to asset
prices, including house prices and the exchange rate, within the
framework of inflation targeting?
Asset prices are important in two (separable)
Although separable, these two perspectives on
asset prices are related. The effect on the outlook for activity/inflation
of a change in asset prices will depend on what was the underlying
cause of the change. One diagnostic of the shock can be any changes
in relative asset prices; for example, a shock to the inflation
regime and so to inflation expectations would, in principle, increase
the yields on nominal bonds but not yields on RPI-indexed bonds.
In practice, such diagnosis is fraught with uncertainty, in particular
because asset prices can be temporarily or even persistently affected
by institutional influences on demand and/or supply and because
of the difficulty of identifying changes in risk premia more generally.
Should the Committee in any way target asset
pricesin general or in particular? No. First, that would
clearly be contrary to the Government's remit. Second, the Committee
has one instrument, so there would be confusion if it were trying
to hit more than one target. Thirdeven if the remit were
changed, or the Committee were somehow given another instrument
(neither of which I advocate or believe feasible)the Committee
could not know what level of asset prices to target. Fourth, even
if it did know what level to target, I doubt it could influence
asset prices sufficiently to bring them to the desired level.
9. Is it appropriate to concentrate on the
projection of RPI(X) at the two-years ahead point?
The significance of the two year forecast horizon
is that, on average in the past, it is roughly where a change
in the official interest rate has had its maximum effect on inflation,
while of course there is some effect on inflation sooner than
that. There are, though, a series of riders to this:
10. Do you believe that there is any trade-off
between inflation and unemployment (or output) in the short-run
or in the long-run?
(1) There is a generally recognised
trade-off in the short-run.
(2) In the long-run, I believe
there is no such trade off. A monetary expansion finds it way
into the price level, with output and employment determined by
real economy/supply side factors. It is plausible, in fact, that
the opposite of the short-run trade off holds, with low and stable
inflation enhancing the long-run performance of the real economy.
First, in an environment of high and unstable inflation, longer-maturity
nominal debt contracts would plausibly carry not only a premium
to compensate holders for expected inflation but also a risk premium
given the uncertainty about future inflation outturns. To the
extent that investment is financed by longer-maturity nominal
debt, such a risk premium would add to the real cost of capital.
In a stable monetary environment, that risk premium might therefore
be saved, helping to support investment. Secondly, in a stable
monetary environment, households, firms and entrepreneurs should
find it easier to disentangle changes in the general price level
from changes in relative prices, potentially aiding an efficient
allocation of resources - including to investment projects.
11. What are the consequences of the current
imbalances within the economy for future inflation and growth?
What can monetary policy do to address these imbalances?
Imbalances have for a while characterised the
economy in three ways which, although closely related, it is helpful
to separate:
These imbalances have been rooted in a series
of shocks to external demand combined with the strength of sterling
against the euro (and for a while in the mid-late 90s, against
the dollar too). Monetary policy has responded to the weak (in
fact, persistently negative) contribution of net trade to output
growth by stimulating consumption growth in order to keep the
path of aggregate demand in line with the economy's supply potential.
Looking ahead, this poses risks through a number
of potential sources. For example, the accumulating debt will,
other things being equal, leave the household sector more vulnerable
than otherwise to "bad luck" with the possibility of
abrupt adjustment; or the euro may rise against sterling. It is
very difficult to judge whether the unwinding of the imbalances
would put upward or downward pressure on inflation. That would
depend on the circumstances in the economy at the time. But the
greater the imbalances become, the greater the risk of abrupt
adjustment, and so the greater the possibility of undesirable
volatility in inflation (and activity) in future.
What can monetary policy do about this? Little
if anything to affect the external environment, and so little
to reduce the imbalances directly. It can, perhaps, by consistently
achieving the inflation target and so accumulating credibility,
help to anchor inflation expectations in the medium term, which
may help to stabilise inflation if/when the imbalances unwind.
12. What is your assessment of the outlook
for UK productivity growth?
The most likely outlook is probably that productivity
growth remains in line with its long-term average of around 2
per cent. A central estimate is needed but there is inevitably
considerable uncertainty about it. This issue is perhaps especially
difficult to judge at present. On the one hand, if the US economy
has enjoyed a material improvement in underlying trend productivity
growth over the past half decade or so, stemming from technological
change and the organisational efficiencies it permits, that could
reasonably be expected to spread to other economies over time.
In principle, flexibility in the UK economy should help it over
time to share in those gains. On the other hand, the extent and
persistence of the US improvement is still difficult to judge;
and it is not so far obviously apparent in the UK data. It is
an issue where I hope to learn from talking to business managers
around the country.
13. What weight do you place on (a) the monetary
aggregates and (b) the output gap in your assessment of inflation
Inflation is a nominal (or monetary)
phenomenon. The price of goods and services is expressed in terms
of money; and inflation is a rise (or fall) in the general
level of prices. Thus whileas part of keeping inflation
pressures in balance (see (b) below)the MPC has to aim
to keep real aggregate demand in line with aggregate supply,
that is strictly consistent with any rate of inflation. It is
therefore vital to track nominal indicators. The monetary
aggregates are, by definition, nominal and therefore warrant monitoring.
Interpreting both narrow and broad money has, however, for a long
time been complicated by changes in the pattern of demand for
money (so-called velocity changes) reflecting, for example, changes
in the characteristics of the saving and instant-access deposit
facilities provided by banks. Nevertheless, in order to help avoid
big mistakes, the monetary aggregates can potentially provide
a useful source of questions: the relationship between persistent
rapid monetary growth and rising inflation is well established
Even if the relationship between the monetary
aggregates and GDP/inflation was so unstable as to make them useless
as an indicator, that does nothing to alter the importance of
monitoring nominal variables. In the UK set up, various
measures of inflation expectationsfrom surveys, derived
from bond markets, etc - are very important in this respect. Keeping
medium-long inflation expectations in line with the target is
necessary to achieve inflation in line with the target over time.
Separately, the sectoral money and credit data
can provide useful insights on developments in the household and
business sectors.
From a position of balance, a reduction in interest
rates (monetary expansion) will tend to lead to a positive output
gap and thus to inflationary pressure, and vice versa for an increase
in interest rates.
The output gap is a real economy concept. In
terms of thinking about monetary policy choices, it is important
in focusing on levels rather than growth rates. Keeping inflation
stable requires the level of output to be in line with
the economy's potential supply capacity rather than just the growth
rate of output to be in line with trend growth. Thus, for example,
in the face of a negative shock to demand taking the level of
GDP below potential, output may need grow at above its
trend growth rate for a while in order to bring inflation back
to target.
In practice, things are somewhat less straightforward,
as the supply capacity of the economy is not directly observable,
and estimating it is hard, subject to uncertainty and error. A
range of tools should be helpful: econometric estimates, indicators
of cost and price pressures, survey and other indicators of spare
capacity, anecdotal information, etc.
14. To what extent should fiscal policy play
a demand management role alongside monetary policy in the short-run?
(1) The most important contribution that fiscal policy
can make to monetary stability is to maintain a prudent level
of government debt, so that there is no question of the
country needing to inflate away its debts to remain solvent. The
UK is most certainly in that position at present, and has been
for some years.
(2) Fiscal choicesthe size of government
spending, and the extent of deficit or tax financingare
matters for the Government. The job of the MPC is to understand
any fiscal policy changes so that they can be taken into account
in its projections of output and inflation.
15. What role should econometric models play
in the formulation of interest rate policy?
Not only econometric models, but economic models
more generally are essential to policy formationalongside
more anecdotally-based assessments of prospects. Since policy
has to be forward-looking, a forecast is an essential ingredient
of the policy process. Econometric models bring the benefit of
ensuring that analysis is framed in a consistent way, so that
wider effects of assumptions/judgments about one part of the economy
are traced through. But econometric models are based on estimates
of relationships prevailing on average in the past. This
calls for alertness to whether key relationships change; and for
a focus on identifying the particular pattern of shocks affecting
the economy at any time, since the coefficients in the model will
reflect the average of all past shocks. More structural models,
attempting to get at underlying behaviour, can sometimes contribute
to that and so to the judgments which have to inform the
forecasting and policy process.
16 May 2002


text:
The Benefits of Saving
The following tools and resources will help you gain a clear line of sight between your cash flow, your bills and your savings goals.
Figure out how much more you can saveUse the calculator
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See what it will take to reach your financial goalsUse the calculator
Saving for a rainy day with monthly contributionsUse the calculator
Should you save or pay down your debt?Use the calculator
Create and Maintain a Budget
The following resources can help you set reachable goals, maintain realistic expectations and stay on track as comfortably as possible.
Create a budget based on your needs, wants & goalsRead the article
Analyze your spending habitsUse the calculator
Balance your checking accountUse the calculator
Learn how to build a useful family budgetRead the article
Find out how to stop spending more than you're savingRead the article
Compare your income and your expensesUse the calculator
Additional Information
Or call
Learn more about Digital Banking
Secure account access to keep your finances streamlined and organized
Get the Mobile & Tablet Banking app
Make deposits, pay bills, transfer funds and manage your account on the go


text:
Our corporate offices and operations staff are headquartered in Colchester, Vermont.
Physical Address:
356 Rathe Road
Colchester, VT 05446
Phone: 802-338-9336
Hours of Operation
Monday-Friday: 7:00am-4:30pm
Green Mountain Electric Supply, Inc. provides innovative solutions to the electrical and renewable energy industries. Through a commitment to highly trained staff, changes in technology, new products, and strong partnerships with customers and vendors, our mission is to lead the industry in innovation and to provide excellent service with honesty, integrity, and urgency.