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Technology updates and upgrades are part of the IT infrastructure life cycle. However despite the best intentions of the person(s) responsible for changing upgrading or modifying a system or solution, deploying changes can be one of the most difficult challenges IT teams face. Often resistance to change comes within the organisation itself, which is risk adverse, getting stakeholders onboard with a major change sometimes requires substantial skills in people management. That being said, this article describes the necessary steps to execute an effective change within any IT operations department.
The components of a successful change management practice should include as a minimum:
|1. Reason for the change
|5. Resources needed to complete the change
|2. Benefit to the end user
|6. A secure back out plan if the change is not successful
|3. Disruption to the business
|7. Change approval
|4. Time required to complete the change
Changes of any type should be conducted outside normal business hours, or at times when user traffic is at its minimum. If you are operating in a managed service model, where alarm monitoring occurs, the change needs to include acceptance from the network operations supervisor, if it is going to create management alarms. At times, change management is required to correct issues in software or hardware configuration.
The ability to track those changes for auditing purposes becomes necessary, especially in the event of a roll-back or back-out due to unforeseen failure. Ensuring availability of server logs or system state information becomes critical if an organisation uses automated change agents within the network. In case of large networks, automating the process of distributing software updates or configuration changes can save hundreds of man hours over a calendar year.
However, evaluating whether the change was completely successful will depend on the quality of the available audit information. Most network change management suites consist of a modelling application that allows organisations to build the complete network in a virtual environment that runs the exact same configuration as the live network.
This allows the simulated deployment of a complete configuration change to be evaluated before it is committed to the live network. If your organisation doesn't have the luxury of a fully automated change suite, or the type of planned change cannot be simulated then the following steps can be followed to realise an effective network change.
Reason for the Change
Regardless of the change you are planning, it is important to inform all the relevant parties involved the reason for the change. Usually the reason will determine when the change will occur, and will be dependant on it's importance to the users of the system. Usually taken for granted, but here are the questions which will be asked.
- Is an outage required? Can the change occur without outage?
- What is the benefit/impact to the end user?
- Can the change be merged with other planned change events?
- How critical is the change?
If the change is major, it is important that sufficient resources are allocated beforehand, usually a project manager or some other responsible person should produce a change plan which all stakeholders can agree upon.
Change Risk Register
Many change requests have dependencies which can affect the overall change, sometimes the simplest things can cause a planned change to completely fail, such as site access, or cable length being too short. The risk register should contain a list of concerns which the initial stakeholders provided during the initial meeting. It is critical that open items on the risk register are closed or satisfied before the actual change occurs.
Responsibility Matrix
This is simply a list of who, what and when. Prior to the changes, many things must occur first. For example, purchase orders may have to be raised for external resources, equipment may require purchasing and some additional planning may be required. The responsibility matix covers the task and when it must occur. Make sure names of people are recorded by each task and a completion date is also included.
Change Simulation
Depending on how critical the change is, it may require evaluating in a test environment first. This can be useful to determine how much time is required to effect the change, and to iron out any unforeseen problems beforehand. A change to swap a copper ethernet connection to fiber is an excellent candidate for change simulation especially when redundant connections are involved, and fail over doesn't work as expected.
User Notification
Communicate well in advance with the end users, is vital to any successful change. Multiple announcements should be sent to affected users by email, and should contain as much information as possible, but as a minimum must include.
- Reason for the Change
- Benefit to the user
- The outage time
The Backout Plan
Change management is a bit like robbing a bank, usually it happens in the middle of the night and there is only a short amount of time. There needs to be hard time limits attached to each activity. Ultimately it is the project/change manager who decides to execute the back out if the change exceeds 75% of the allotted time. Questions to ask stakeholders regarding the backout plan prior to the change.
- Can we provide 100% service restoration in the event we have to back out?
- What logs or information can be captured to report to management as to the reason for back out execution?
- Is there a point of no return where the backout plan is ineffective
Change Closure Report
This final aspect of most changes is often overlooked. It should be included especially if similar change events are planned for the future. The report should include a list of events which went well, events which proved difficult, and events which could be done better next time.


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The Hadrian Hotel is a 18th Century stone built Inn situated in the Northumbrian village of Wall, less than a mile from the Hadrian�s Wall path and the site of the Battle of Heavenfield. It is the perfect stop when walking either to or from Twice Brewed. Alternatively, if the guest would like to spend more time at the various Roman sites between the Hadrian Hotel and the Twice Brewed we offer a pick-up service, staying the night at our 12th Century stone built coaching in; the Red Lion at Newbrough.
Delicious freshly made modern British pub food using locally sourced ingredients and stock a great selection of quality wine, spirits, soft drinks and real ale at the bar.
Distance from path: One mile south.
Alternatively, you might like to try the following hotels just outside Wall...
Greencarts Farm, Chollerford, 1 mile on from Wall.Swallow George Hotel, Chollerford, 1 mile on from Wall.Battlesteads Hotel, Wark, 1 mile on from Wall.The Dovecote, Chollerford, 1 mile on from Wall.
If you have accommodation already arranged in Wall, please enter the
details below so that we can arrange baggage transfer. You will not be
charged a booking fee for this stop.

subset: commoncrawl


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Erin Greenwood
About Erin
BioHi! I am Erin Greenwood. Welcome to Nevin Platt Middle School and my 6th grade science classroom. I have had the privilege and challenge of teaching middle school for 11 years in Boulder, Colorado and see my job as a calling rather than work. While hard work is certainly a hallmark of my teaching style and the learning environment in my classroom, I also strive to inject humor, silliness, fun, failure, enthusiasm and play into the learning process. I believe that it is possible to learn more when we are fully interested, engaged and enjoying the messiness of the learning process!


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I had the pleasure of meeting the ladies behind MADE Jewelry at the San Francisco State University PACE Fashion Show. Talk about WOW! Their pieces are all handmade to perfection, using materials like: silver, gold, natural stones, rare charms and other one-of-a-kind materials.
What makes MADE Jewelry unique? Well, for starters, the owner/designers Debbie Sheen and Abigail Rivamonte, are super friendly and want to ensure that you are accentuating your best features and revealing your personal side with their jewelry. Who doesn't love that?! Take a look at my top picks and read more after the jump!
The earrings below, Smitten, are from MADE's AM Collection. These are for the heartbreakers! Retail: $45.
The Escargot's below are from MADE's PM Collection. I love the details these earrings offer and the elegance they exude. Retail: $30.
Now, my all time favorite piece from MADE Jewelry is from their Wrap Collection, it's called I Left My Heart in the Bay. This is my top pick because even though I am an L.A. girl at heart, moving to San Francisco has changed my life in so many good ways, that I can't help but love it here. So, no matter where I venture off to in the future, a piece of my heart will be left in the bay. Retail: $40.
Support the ladies on their mission of providing "an uncompromised style that empowers freedom and movement."
Visit MADE Jewelry for more information.
Similar Posts:
- Merci! M.I.S.S. Thanks Made Jewelry
- Miss Wax & Love+Made Present the Look of Love
- M.I.S.S. Vegas Review: Made Jewelry at Pool
- My Latest Obsession: Chan Luu
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Paperback picks: SheKnows' sizzlin' summer book guide
It's summer reading time -- by the pool, in the sand, at home, wherever your vacation takes you. We've got you covered with our SheKnows sizzlin' summer book guide, regardless of your format of choice (hardcover, paperback or eReader). Here are five great paperback picks -- so sit back, relax and read.
#1 The Summer Without Men by Siri Hustvedt
Mia Fredrickson, the wry, vituperative, tragic comic, poet narrator of The Summer Without Men, has been forced to reexamine her own life. One day, out of the blue, after 30 years of marriage, Mia's husband, a renowned neuroscientist, asks her for a "pause." This abrupt request sends her reeling and lands her in a psychiatric ward. The June following Mia's release from the hospital, she returns to the prairie town of her childhood, where her mother lives in an old people's home. Alone in a rented house, she rages and fumes and bemoans her sorry fate. Slowly, however, she is drawn into the lives of those around her -- her mother and her close friends, "the Five Swans," and her young neighbor with two small children and a loud angry husband -- and the adolescent girls in her poetry workshop whose scheming and petty cruelty carry a threat all their own.
Bottom line: A provocative, witty and revelatory novel about women and girls, love and marriage, and the age-old question of sameness and difference between the sexes.
#2 The Stormchasers by Jenna Blum
While growing up, Karena Jorge had always been the one to look out for her brother Charles, who suffers from bipolar disorder. Always obsessed with severe weather, Charles began chasing storms, and his behavior grew increasingly erratic until a terrifying chase with Karena ended with deadly consequences, tearing the twins apart and changing their lives forever. Two decades later, Karena, now a reporter for the Minneapolis Ledger, gets a call from a mental health ward in Wichita, Kansas, to come pick up her brother, whom she hasn't seen or spoken to for 20 years. She soon discovers that Charles has lied to the doctors, taken medication that could make him dangerously manic and disappeared again. Having exhausted all her reporter's resources to track him down, Karena realizes she has only one last chance of finding Charles: the storms. Karena joins a team of professional stormchasers -- passionate adventurers who will transform her life and offer her a chance for love and redemption -- and embarks on an odyssey to find her brother before he does more damage to himself -- or to somebody else.
Bottom line: An electrifying summer read that will have you chasing through to the end.
#3 Hotel No Tell by Daphne Uviller
Hotel No Tell follows Zephyr Zuckerman, on the verge of 31, a junior investigator with New York City's Special Investigations Commission (SIC). She's undercover as a concierge at the Greenwich Village Hotel, trying -- and failing -- to track down a missing 100,000. Her detective boyfriend has moved out because of their disagreement about reproducing (he wants kids, Zephyr doesn't), and she's left with her Holland Lop bunny named after a famous atheist, an old friend who's married and miserable in suburban motherhood, and one new friend who's a wedding planner in dire need of an exorcist. It soon becomes clear that the trouble at the hotel goes much, much deeper than a little old-fashioned laundering. Before Zephyr can master the reservation system, she is yanking at the threads of a multi-million dollar egg donation scandal and re-examining her own motives for opting out of mommyhood.
Bottom line: A zany, loveable heroine and whip smart chick lit mystery/caper, what's not to love? This is the second novel featuring Zephyr, though it's not a sequel. If you fall in love with her, try Super in the City, the first book to feature this unforgettable character.
#4 Love in Mid Air by Kim Wright
A chance encounter with a stranger on an airplane sends Elyse Bearden into an emotional tailspin. Suddenly Elyse is willing to risk everything: her safe but stale marriage, her seemingly perfect life in an affluent Southern suburb, and her position in the community. She finds herself cutting through all the instincts that say "no" and instead lets "yes" happen. As Elyse embarks on a risky affair, her longtime friend Kelly and the other women in their book club begin to question their own decisions about love, sex, marriage and freedom. There are consequences for Elyse, her family and her circle of close friends, all of whom have an investment in her life continuing as normal. But is normal what she really wants after all? In the end it will take an extraordinary leap of faith for Elyse to find -- and follow -- her own path to happiness.
Bottom line: We raved about this book when it was in hardcover last year (it was a SheKnows Book Club pick), and now that it's in paperback (July 14) with a fabulous new cover, we can't wait to read this intelligent, sexy, absorbing novel about modern-day marriage all over again.
#5 Still Missing by Chevy Stevens
On the day she was abducted, Annie O'Sullivan, a 32-year-old realtor, had three goals -- sell a house, forget about a recent argument with her mother and be on time for dinner with her ever-patient boyfriend. The open house is slow, but when her last visitor of the day pulls up in a van as she's about to leave, Annie thinks it just might be her lucky day after all. Interwoven with the story of the year Annie spent as a captive of a sadistic psychopath in a remote mountain cabin, which unfolds through sessions with her psychiatrist, is a second narrative recounting events following her escape -- her struggle to piece her shattered spirit back together and the ongoing police investigation into the identity of her captor.
Bottom line: Mesmerizing, thrilling and not easy to read. But also very hard to put down. If you love a good thriller, this is the book for you.
More SheKnows Sizzlin' Summer Book Guide
Hot in hardcover: 7 Great books of summer
Hot eBook of summer: Twang
YA rules: 5 Hot young adult books


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The world has definitely become smaller the more connected we are. It's much easier for anyone these days to be globally minded and connect with someone in the other side of the world and to learn about different cultures without leaving your home. But that doesn't necessarily mean that individual societies are also more open and diverse racially, culturally and ethnically. Some days when you turn on the news it actually feels like whole groups are becoming much more closed minded out of fear of losing their cultural identity over others.
But our children are the future. Our children can individually be a friend to the whole human race. They are born into the era where technology has reduced both space and time, allowing us to very easily reach out of our own bubble and know that there's more.
It's our task to ensure that we provide an opportunity and an environment for our kids to become globally minded citizens of the world. Compassion, empathy, an open heart and an acute emotional intelligence accompany children with global minds that are at ease in different cultures, languages and races.
I'm doing my bit with my daughter by making sure she's bilingual from birth (and hopefully multilingual soon!) and is well connected to the two countries where her parents are from: Mexico and El Salvador. I also obsessed over making sure she got enrolled into a language magnet school where she's in the Spanish program, but is exposed to the other three languages being taught in dual immersion models in her school: French, German and Italian. This constant exposure to so many languages in her own school yard and hallways has already made her aware that there's a huge world out there with different ways of thinking, living and speaking.
But I know there's more we can all do, so I reached out to 20 of the most well-known parenting bloggers and authors on the topic of raising multicultural, multilingual and compassionate children and asked them to share their #1 tip on raising a globally minded child.
20 Expert Tips on Raising a Globally Minded Child 1 of 21
They truly are the experts living what they preach.
Modeling through thoughts, words, and actions 2 of 21
We hope to raise our daughter to be globally-minded by modeling through our "thoughts, words, and actions". For example, we talk about and travel to our different homelands, we read and share about different cultures, we play and learn in another language (Spanish), and we live in a multicultural city.
Giselle Shardlow
Be a friend to the whole human race 3 of 21
The photo is of my daughter in her pre-school while we lived in the Gambia. A theme that became so clear to me, seeing my children interact in a new country, was "Be a friend to the whole human race." As I saw them make friends I realized that being a global citizen truly is an extension of seeing ourselves as a friend to all. Friendship is a universal theme, something every culture and every age values. So if you break down the idea of what it means to be a good friend loyal, caring, kind, helpful, non-judgemental, and sharing fun times/exploring together then this can de-mystify what it means to be a global citizen.
As my children were growing up (the oldest is in college now), we considered if our actions and attitudes reflected that of a "friend to the whole human race." And this way, global citizenship felt like such a natural extension of our daily lives.
Homa S. Tavangar
Author, Growing Up Global: Raising Children to Be At Home in the World (Random House/Ballantine Books)
Multiple languages are windows to the world 4 of 21
We're trying to raise our kids in a way that being around cultures, religions and languages different from our own is the norm versus a one-off experience. One critical leg of this three-legged stool is language. Start as young as possible! Mine have grown up with Arabic since birth, we started French classes when they were 2 and 4 and more intensive immersion Spanish at 3 and 5.
The more languages they can speak, the more windows on the world we are giving our children.
Stephanie Meade
An unprejudiced grasp of culture and identity 5 of 21
We're a multicultural, bi-racial family of five - my husband's Pakistani, I'm Irish, our two daughters were born in England and our son, in Scotland. We currently live in Canada.
Because of their mixed heritage, it's vital our children have a firm, unprejudiced grasp of culture and identity. We help them embrace cultural difference through diet and dress, an open attitude and an understanding of the balance between fitting in and remaining true to yourself. But as well as talking about difference, we also discuss how people everywhere share commonalities like fear, joy, hunger, excitement and fatigue - whatever a person's skin-colour, language, dress or behaviour, they all eat, fart, laugh or cry.
I think this is what makes our kids so outgoing and compassionate, they constantly make me proud with their kindness and courage.
Aisha Ashraf
Expose them to diverse cultures from an early age 6 of 21
My number 1 tip for raising globally minded children is to expose them to diverse cultures from an early age. Kids will develop awareness and appreciation for diverse languages and cultures if we as parents show them to appreciate the richness and beauty of other cultures. I am lucky to live in the most ethnically diverse county in the US (Queens, NY) , and Enzo's toddler classes are a wonderful mix of religions, ethnicities and languages! For us, it is very important that he is surrounded by diversity and that he learns to respect other cultures from an early age.
Diana Limongi
Read books from around the world 7 of 21
I'd love to share my thoughts on one way we've adopted in our family to raise our children to be globally-minded citizens and that is through exposing them to diverse children's literature. We regularly handpick and read books from around the world to experience other cultures from the comfort of our home. Reading stories set in varied cultural backdrops particularly with kids like themselves in dissimilar circumstances and through books on the geography of faraway lands we nurture in them respect and empathy towards peers and people from other cultures, religions and races. Additionally, it creates better awareness and understanding of the bigger world they are part of which is important to be globally-minded always.
Meera Sriram
Teach them a love for life 8 of 21
My #1 tip on raising globally-minded children is teach them a love for life, different cultures, and to embrace their own cultural identity. A good way to do this is by helping them expand their horizons of our culturally diverse world through every day events, such as festivals, trying out ethnic foods, making cultural crafts, reading multicultural books, and traveling.
Frances Diaz Evans
Books with characters from around the world 9 of 21
Our family reads lots and lots of children's books with characters and stories from around the world. The kids also have a world map they can reach where we find and talk about the different places in which the stories take place.
Kali Carollo
A global view 10 of 21
No matter how global your view, their world will be bigger than you ever imagined. Don't let your agenda, your fear, or your love, limit them.
An attitude of gratitude 11 of 21
Engage. Get involved with diverse communities and encourage questions. And as they develop an understanding of the world, develop an attitude of gratitude for what they have, for who they are, for what they learn, and for who others are, for what others have to offer.
From raising three kids in Djibouti, Somalia, and Kenya over the last 11 years, we have definitely learned the importance of thankfulness.
Rachel Pieh Jones
Treat others how you would want to be treated 12 of 21
My number #1 tip for raising global citizens is to show and tell them about as many different cultures as possible. We have been fortunate to travel with our children a lot, but even if you can't travel internationally, you can still experience the world in your own city through different museums, cultural fairs, festivals and even restaurants.
We also talk a lot about respect and acceptance. Accepting people for who they are, where they come from, what they look like or what they believe. It's been said before but is so true and worth repeating, "Treat others how you would want to be treated."
Andrea Fellman
Never give up 13 of 21
Never give up! Since I had to become more globally minded before I could raise my child that way, it's been quite the journey already and he's only one! It's important not to give up and keep going. Make mistakes and enjoy the journey!
Jeffrey Nelson
Travel and cultural experiences 14 of 21
Through travel and cultural experiences you can encourage children to be aware of and embrace many similarities and differences in the world. At home it's fun to use cooking, books, music, art projects, clothing and videos to experience various countries virtually since we can't travel everywhere on a budget.
Kim Vij
Respect for the uniqueness and value of everyone 15 of 21
Help your global kids to build a sense of genuine respect for the uniqueness and value of everyone, and to recognize their responsibility to help create an environment of peace for the planet. From a global perspective, my hope is that a growing number of children are being raised to value the principle of peace and its benefits so that as adults they will be more willing and able to engage in peaceful and cooperative pursuits with others within their community and, ultimately, around the world.
Jill Sedita
See everyone as part of one human family 16 of 21
I am trying to raise my boys to see everyone as part of one human family. We do this through teaching the principle of "unity in diversity" - celebrating differences within the context of our underlying unity.
Share a meal from a different country 17 of 21
My family and I share a meal from a different country every week. We've been doing it since my daughter turned seven months old. We're almost done cooking the world; my now four-year old daughter has grown up appreciating and respecting other cultures, plus it literally spices up dinnertime!Sasha Martin
The world in your city 18 of 21
I feel fortunate that my family lives in a vibrant, diverse city like Chicago. We try to visit as many of its neighborhoods to experience new cultures, people, places and foods. It's a great way to open our sons' minds to the world - without leaving Chicago.Aimee Thompson
Show them the world 19 of 21
Show them the world: show them how other people live, eat, play, work, etc. The daily little things matter.
Connecting to our own cultural background and heritage 20 of 21
One of the things I highly recommend to families if you are wanting to raise globally-minded children is to travel. I know it sounds basic, but so many people think that the only way to raise globally-minded children is by leaving their own country. Even better, let's start by connecting our children to our own cultural background and heritage.
Mari Tuten
Be curious and appreciative 21 of 21
I think the most important thing is to be curious and appreciative yourself about the diverse countries, cultures, and traditions of our world.
Buy the book I co-authored, Bilingual is Better: Two Latina Moms on How the Bilingual Parenting Revolution is Changing the Face of America.
Read more from me at


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Wife. Mother. Writer. Traveler.
Lacey Tezino is a creative soul, occupying a beautiful life with her family in Houston, Texas. Founder of her new business, Passport Journeys, Lacey is tapping into her passion for helping mother-daughter relationships and inspiring forgiveness, growth & connection.
Married to a man who honors my heart, blows my mind & takes care of the life we are creating..
Mother to a baby that makes my tiny space on earth feel like we rule the entire planet.
Wander lust searching the whole world for cultures that make me fall in love with "different" and appreciate home.
2018 LIVE news segment: CW-39 with Maggie Flecknoe
HOUSTON -- It's a new year and a fresh start for relationships.
Lacey Tezino, founder of Passport Journeys, is helping mothers and daughters build a stronger relationship this year. Tezino's activity book is a tool to guide mothers and daughters through a 12 month journey to a closer relationship with one activity per month. This journey requires the mother and daughter to be in the same location each month, and lays out the needs for each activity.
Tezino sat down with CW39's Maggie Flecknoe to talk more about her own journey and how she wants to help other mothers and daughters.
Click here to get your own "passport".
Podcast feature: UNTAMED Podcast by Lu Uhrich
"Lacey is a writer, mentor, adventurer, and public speaker who is passionate about encouraging young people to travel, fall in love with other cultures, and cultivate positive relationships. Through her work managing hospital projects, Lacey spent the last 3 years living in Doha, Qatar where she helped to digitize the health system for the entire nation and traveled the Middle East. Although she is passionate about her career, her calling to inspire others through transparent social media connection and speaking engagements is becoming more evident. Lacey is currently in the process of writing her first book, a memoir about being raised in a white community and growing into her own truth. She also facilitates dynamic conversations about racial equality for children."


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Demographic transition
Lesson 11 of 16
Objective: Students will be able to: 1) articulate the key elements of the demographic transition (DT) model; 2) construct graphs of contemporary demographic change; and 3) explain contemporary demographic patterns in the context of the classic DT model.
Big Idea: The demographic transition model describes how populations change over time. How might we use this model to explain how the population growth trends of countries will stress the Earth's limited natural resources?
What factors cause changes in the shapes of population pyramids? "Demographic Transition" links students' understanding of population pyramids with an explanatory theory that will be essential for success with the Unit CAPSTONE. Why do some human populations grow more quickly than others? Why is the life expectancy higher some countries? Is there a predictable pattern that population pyramids follow? These are the types of questions that students will be expected to answer by the end of this lesson.
Students need to understand the basic ideas of the demographic transition model in order to provide evidence-based claims that describe why human population pyramids differ and how population pyramids will change over time. This lesson provides a powerful analytic framework. Students will use it to make sense of human population growth over time. Students will also use it to consider potential solutions to problems people face in different societies. How might we reduce infant mortality? How might we stabilize population growth? How might we decrease the environmental impact of country?
This lesson begins with an exploration of the demographic transition as a FLIPPED assignment before class. In class, students first share ideas about the demographic transition theory that they learned from the FLIPPED assignment and then work through models of the theory from video and text resources. Next, students work through an interactive apply their emerging conceptual knowledge to case studies. How does the shape of a population pyramid impact a country's stage of demographic transition? Finally, students will work with data from the United States Census Bureau to assess their understanding of the demographic transition theory.
HUMAN DEMOGRAPHY SEQUENCING NOTE: For an overview of what students will learn about human demography and how this learning builds towards the CAPSTONE for this unit, see the outline below:
7 Billion : Students learn about factors that have influenced the growth of the human population over time.
Focus question: How has the human population grown so large so quickly?
Cemetery secrets: Students learn that modeling the survivorship of different human societies reveals that human demography data is heterogeneous. The "human population" is actually many human populations, separated by geography and time.
Focus questions:
- What data can we use to study populations of the past?
- How can we model the death rate of a population?
Human Population Pyramids: Students learn how to develop the population pyramid data visualization tool to formally represent an analyze the various human populations throughout the world. In this process, students develop an evidence-based understanding of how different population structures uniquely impact the Earth and how these unique impacts will become more or less intense over time.
Focus questions:
- How can we represent the essential demographic data of a human population using an elegant data visualization tool?
- What demographic information does the shape of a population pyramid reveal and how does this shape predict future a population' future growth?
- How might the population pyramids of countries be used to develop public policy?
- How do different rates of development within a country influence how specific human populations will impact the environments?
Demographic Transition: Students learn about a model of how population change over time and use this model to describe how human populations will impact the Earth in the future.
Focus question: How do different rates of development within a country influence how specific human populations will impact the environment?
PRIOR KNOWLEDGE NOTE: Students should have demonstrated proficiency with survivorship curves prior to this lesson. Population pyramids are another data visualization tool that will require many of the same skills that students needed for survivorship curves, such as collecting data, processing data for use in a graph, plotting data, drawing conclusions from data, comparing the meaning of different graphs, and using data visualizations to make predictions about future population growth.
RESOURCE NOTE: The attached PROTOTYPE ACTIVITY GUIDE contains a series of learning activities that might be modified by educators for classroom use.
Resources (1)
Resources (1)
What is the purpose of this section?
BEFORE this lesson students extract information from two instructional videos so that they can describe the general idea of the demographic transition theory as well as the relationship between the theory and the shape of population pyramids. By the end of this FLIPPED assignment students should be able to describe the demographic transition theory in words or through data visualization; students should also be able to match at least one population pyramid shape to a stage of demographic transition.
What will students do?
Students will view two short videos and answer questions about each. Students will also write a short summary paragraph of the content from both.
VIDEO ONE: The Four Stages of Demographic Transition
- What are the key characteristics of the first stage of demographic transition?
- What are the key characteristics of the second stage of demographic transition? (Hint: the differences between the first and second stage are important.)
- What are the key characteristics of the third stage of demographic transition? (Hint: the differences between the second and third stage are important.)
- What are the key characteristics of the fourth stage of demographic transition? (Hint: the differences between the third and fourth stage are important.)
VIDEO TWO: Demographic Transition and Population Pyramids
- What are the variables described by the demographic transition model?
- What would be an example of a high growth rate?
- Which stages of demographic transition have a high rate of population growth?
- What causes population growth rate to reach zero?
- How does a population pyramid provide information about stages of demographic transition?
Summary: What are the most important features of the demographic transition theory? What information can a population pyramid provide about a stage of demographic transition? Explain in words and with a diagram.
RESOURCES NOTE: Both videos are attached in case youtube is blocked within a school. These videos are from a third party and attribution information is available from the host pages linked above.
Resources (2)
ENGAGE: Main idea jam
What is the purpose of this section
Students build on their understanding of the FLIPPED assignment to summarize the purpose of this lesson and suggest ways to use the demographic transition theory to predict future human impact on the environment. The teacher collects valuable formative assessment data. By the end of this section, students should be able to describe the purpose of this lesson to a classmate and make one prediction supported by evidence about how the human population will impact the environment in 2050.
What will students do?
Student engage with this video presentation and summarize the main ideas in one paragraph. Then students will answer the following question: If the world population is 9 billion in 2050, what impact will this have on the environment? Students engage in silent peer review once they have finished. Each students in a group pass written summaries to three classmates for written feedback. Do you agree or disagree with the prediction? Why? Finally, student groups will read one prediction to the whole class.
What is the purpose of this section?
The class will learn about the demographic transition model through a teacher-centered mini-lesson format. The teacher will perform explicit modeling and explicitly correct student misunderstanding. By the end of this section all students should be able to describe the causes of demographic transition.
What will students do?
Students will read a short article about the demographic transition model and then annotate a graphical representation of the model. Annotations will emphasize the social and political factors influence a rise or fall in death rate, birth rate, and total population. The teacher will model this annotation process by adding factors to the "What are the stages of the demographic transition model?" graph. Such factors might include improved medicine, education, and participation in the workforce. These are the same factors that students may have identified from the FLIPPED assignment. By the end of this mini-lesson, each student should have at least one factor impacting the birth rate and death rate within each stage of demographic transition.
What is the purpose of this section?
Students will describe the demographic transition stage of one of the countries from "Human Population Pyramids" using the population pyramid of that country. By the end of this section students should be able to match the shape of a country's population pyramid with the demographic stage of that country.
What will students do?
Student groups will be assigned one of the six countries previously studied: Nigeria, France, India, United States, Mexico, and China.
First, each group has the goal of matching the population pyramid of the selected country with the demographic transition stage of that country and explaining the factors in that country that contribute to the identified stage of demographic transition. Students may use one of the following resources for this task:
- BBC explanation (slides 4, 5, and 6)
- This image:
Second, each group will present their findings to the class.
What will the teacher do?
For this task, nearly all students groups are able to match the population pyramid with the stage of demographic transition. What is more challenging is for students to identify the factors that contribute to this stage, such as quality of medical care. Teachers may want to hold a whole class discussion of ideas in order to help students make connections between economic, social, and political factors affecting a population and the population pyramid and demographic transition stage of that country.
What is the purpose of this section?
Students predict the future demographic transition state of a country and connect this future state to the likely environmental impact of that country. By the end of this section students should be able to make an evidence-based prediction about the future demographic state of a country as well as the future environmental impact of that country.
What will students do?
First, student groups select a country to assess that has not yet been studied during class.
Second, student groups use this tool to research demographic data and predict that country's future demographic transition stage. Here is the protocol for conducting this research:
- Choose Population Pyramid Graph from "Select Report."
- Start with 1950 and select every fifth year by clicking on the year while holding the "ctrl" key.
- Select the group's chosen country from the "Select one or more Countries or Areas" box.
- Choose "Individual Country data only" from the "Aggregation Options" box.
- Submit.
- Note the changing population pyramids over time. What stages of demographic transition does this country pass through? What factors are most likely responsible for these shifts?
- Examine the population pyramid of this country in 2050. What is the most likely environmental impact of this country in 2050? For help with this question, consider the resources used at each stage.
Third, students will share findings with the class.
What will the teacher do?
In addition to troubleshooting technology issues, the most important teacher move in this section is push students to use appropriate evidence for their predictions about the environmental impact of the chosen country in 2050. What types of resources will this country use? How will economic, social, or political factors influence this country's use of natural resources? Is this a country that is likely to focus on the health of its environment or will other issues be more important?


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BlackBerry maker, Research In Motion, could be forced to halt sales of the popular smartphone in the US if Motorola is successful in a patent claim it filed on Friday.
The company, who is currently on a high with handsets like the Motorola Droid, Milestone, Dext, Cliq and Backflip, has filed a complaint with the US International Trade Commission (ITC) claiming that Canadian firm RIM is infringing five of Motorola's patents.
According to Motorola, the five patents "relate to certain early-stage innovations developed by Motorola in key technology areas, such as Wi-Fi access, application management, user interface and power management, that are now being used by RIM".
What are Motorola after? The complete halt of BlackBerrys coming into the US, their sale in the United States, and a complete blackout of all marketing, advertising, demonstration and warehousing of inventory.
"In light of RIM's continued unlicensed use of Motorola's patents, RIM's use of delay tactics in our current patent litigation, and RIM's refusal to design out Motorola's proprietary technology, Motorola had no choice but to file a complaint with the ITC to halt RIM's continued infringement. Motorola will continue to take all necessary steps to protect its R&D and intellectual property, which are critical to the company's business", said Jonathan Meyer, senior vice president of intellectual property law at Motorola.
We are awaiting comment from RIM.
We will keep you posted.
UPDATE: A UK high court judge has found thatBlackBerry maker RIM does not infringe on a Motorola patent it seems reports the Calgary Herald.


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Scale Matters I
Lesson 1 of 10
Objective: Students will be able to analyze proportional relationships and use those relationships to solve problems.
Big Idea: Students will use proportional reasoning to find answers while working in a group. As students work in their groups there is opportunity to hear and take part in meaningful discussion to justify proportional reasoning.
Lesson Beginning
The goal of this section of the lesson is for me to be able to see what strategies students are using to support their proportional reasoning. Are they setting up a "traditional" proportion? Are they using multiplication to try to find the answer? I want to see how they are approaching the solution. As students solve the problem I need them to show all of their work so I can determine the level of understanding my students have.
This problem gives an opportunity to analyze student strategies for solving the problem. It may be beneficial to have students justify their answer to a partner if there is apparent misunderstanding. A written summary of the problem-solving strategy written by the students can give a resource for an intervention strategy starting point. Having volunteers come to the board or the document camera to highlight different strategies used will be beneficial for the class. If there are multiple points of entry for solving this problem that will serve as a great opportunity for my students to see.
Problem of the Day: Josie can read 200 words per minute. She is reading a book that averages 350 words on a page. How long will it take her to read 60 pages at this rate? Show our work.
Lesson Middle
Students will work collaboratively to create efficient methods for solving a set of problems. Students will work in their table groups to solve the problems. As the groups work, I will walk around and visit each group to determine their progress and to hear their thinking. The questions on the SMARTboard will guide student work. Each group should attend to the questions and be able to answer the questions when they share their solutions with the whole group. Each group member will contribute a solution and the group will determine which is the best method. On their poster, each group will write a complete solution for each problem. The solution also must include the reasoning for the solution. Every member in the group needs to understand and be able to explain the method that the group chose.
Resources (2)
Resources (2)
Lesson End
A class discussion to highlight and summarize what students learned in this activity will end the lesson today and provide segue into the next lesson. Ask a student group to volunteer to share their problem solving method for the Recipe slide. As they walk the class through their strategy, invite questions from other students to maximize understanding. The questions posted to guide student thinking during group work will be asked as they share solutions. As groups share their work, my questions will be focused on helping students see the connection between the proportions they are using. Have students moved from multiplication to using proportional reasoning? Do they see other ways to approach the problem? Have students seen a way other than the way they chose that is effective? If another group used a different strategy or approach, invite that group to share their strategy and facilitate discussion on differences in strategy. Have a group volunteer to lead the discussion for the other two slides. The posters should be saved to use with the next lesson.


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As much as we hate to admit it, some of us in the blogosphere can't afford to shell out over €125 on what some consider being the Holy Grail in beauty.
I did like many drool over the Clarisonic being drawn in by many bloggers reviews and who can resist being able to choose your very own colour! I did even consider taking the plunge but in no way could I justify it. It was too much of a risk as I found more mixed reviews on the Clarisonic that I could shake a stick at.
After in depth research on alternatives, many like the Clarisonic I decided to opt for a manual version
Here it is in all its glory!
It has been around for years, good know how long! Much longer than the Clarisonic in any case.
It works in the same way as the Clarisonic dose. You pop on your chosen cleanser, pop the Facial Brush under the tap and then brush your face in a circular motion.
I did at first find the bristles hard on my skin; it feels really soft on your hands. I found that if I ran it under the hot tap for a few seconds it softened up. If you have really sensitive skin I would advise you to avoid this.
After I used it for the first time my skin felt really soft. After using it for a week I noticed that the purging stage that many talk about that they experience with the Clarisonic occurred, as it is a manual it takes longer to pass this stage.
I have been using this for over two months; I have to say my skin has really improved. I used to use it twice a day and my skin was much better than it is now, more out of laziness than anything else. My skin is a lot smoother and I don't need to exfoliate as often either [about once a week]
I have a very simple and quick routine for using the Body Shop Facial Brush.
I pop on my cleanser, I then run it under the hot tap for a few seconds then I spend 20 seconds on each cheek going in a circular motion, 20 seconds on my forehead, 20 seconds on my chin and neck and 10 seconds on my nose. I splash my face with cold water and pat dry.
I found the No 7 Radiance Boosting to be the best cleanser as it foams.
Now the best part. The Body Shop Facial Brush comes in at around €4/£3. I Would recommend that you change the brush every three months.
Have you tried this before? What are your thoughts? Would you try this product?


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Would-be Generalissimo Donald Trump is a brand man. At this point, everyone knows that the few billions he has were made slapping his name on products and buildings – not creating them (mostly). That means that Trump's wealth lives and dies by the prestige of his brand in the eyes of consumers. And as you might have guessed, for most American consumers, there is precious little prestige left in the Trump brand indeed.
Most recently, Trumps vulgar comments with Billy Bush have sent his brand into free fall, according to the Wall Street Journal. A new study by brand research firm Brand Keys found that Trump's admitted fondness for surprising beautiful women with kisses and an occasional pussy grab had "negatively affected" his brand. The Brand Keys poll of 1,536 registered voters across the country.
The perceived added value in TV and entertainment – Trump's favorite medium — fell 13 percentage points as of October 9, while the value of the Trump brand dropped 8 percentage points in real estate and 6 percentage points in country clubs and golf clubs, according to Brand Keys data cited by the Journal.
"What we know for sure is that these brand engagement numbers correlate very highly with consumer behavior in the marketplace," Robert Passikoff, Brand Keys founder and president, said. "Consumers will be distancing themselves from Trump-branded products as well." [WSJ]


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St Andrew's hospital leads way in delivering safer health outcomes
St Andrew's Hospital will today launch a new initiative, thanks to the support of Medibank Private, to undertake a study to find out if the number of falls experienced by patients can be reduced by screening before admission and education campaigns.
St Andrew's Hospital has been awarded a grant of $30, 000 from the Medibank Safety and Clinical Improvement Incentive Pool, set up to support private hospitals to improve quality and safety. Falls in hospitals, especially among the elderly, is a significant area of concern for health care practitioners.
At a presentation ceremony held at the hospital today, Medibank praised St Andrew's Hospital's commitment to lifting the standards of patient safety and quality and for leading the industry in improving the safety and quality of healthcare for members.
Medibank Private has dedicated more than $900,000 in funding, through the Incentive Pool to hospitals across Australia to improve patient care and clinical outcomes.
Medibank' Private's Hospital Contract Manager, Eric Wirth said, the incentive pool allows us to work with private hospitals, like St Andrew's Hospital, to reduce the risk of adverse events and encourage innovation and best practice in clinical care in Australian private hospitals.
St Andrew's Hospital will use the grant to implement and evaluate the effectiveness of undertaking pre-admission screening of patients to identify those at risk of a fall and patient education once in hospital to reduce the risk of a fall occurring. The learnings from the study will be shared with other hospitals building on our understanding of effective falls prevention programs.
St. Andrew's Hospital Chief Executive Officer, Stephen Walker, said, "A fall at anytime can have serious consequences for a person. In hospital a fall can seriously impact on a patient's long term recovery.
"Thanks to Medibank Private we'll be undertaking a study into the effectiveness of two initiatives that aim to reduce the number of falls that occur. The learnings from this work will hopefully help hospitals and their patients across Australia," he said.
Mr Wirth went on to say, "Medibank has had an overwhelming response from hospitals to take part in the Incentive Pool and we're very pleased that hospitals share our commitment to improving clinical outcomes.
"We want better health outcomes for our members and the incentive pool forces us to do more than just talk about improving quality and safety.
"We are assisting hospitals to be more innovative, to lift the bar on current standards.
"It's simple really - we want the best health outcomes for our members, we asked hospitals how they could do this, they told us and we are helping them make it a reality," he said.
� Originally $500,000 was made available in 2006, but due to the quality of applications this increased to over $900,000.
� 34 hospitals across Australia were successful in their application
� Total value of approved proposals is $907,488
� Major areas of innovation of applications included:
Falls prevention and management
Improving management of medication
Discharge and re-admission planning
Improving patient communication and education
� A pool of $1 million will be available for distribution in 2007.
For further information please contact:
Libby Woolnough - Medibank Private
T. (03) 8622 5181 or 0411 659 060
E: firstname.lastname@example.com
Back to top


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In 2017-2018 season the Oregon Blaze Gold team will participate in several national and exposure tournaments. Our schedule includes the following (more information as it becomes available):
Fall/Winter 2017
Spring/Summer 2018
Beaverton Blaze maintains a 501-c non-profit status. All donations are tax deductible and directly benefit the players. All league positions are on a volunteer basis. Send email to email@example.com for details on being a sponsor


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Soy wax melters enhance with a flameless aroma in any room. We liberally hand-pour our melters right into resealable packaging that features six squares of your favorite 1803 aroma. Each melt is topped with dried goods to add an accentuating touch of attractiveness and texture. We combine pure soy wax from soybeans grown in America with our reminiscent scents. Depending on your warmer size, we suggest using one to two squares of wax.
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Why is marijuana such a big deal with law enforcement?
A: It employs people and makes the state money. How many lawyers, judges, police, probation officers, corrections officers, rehab centers, and on and on would be out of a job if it was legal. It depends on the attitude of the community. In many places, the attitude towards private use is "leave them alone". Elected officials get the message and it is conveyed to police and prosecutors. The Obama administration''s attitude, at least towards medical use, is healthy, but the real solution is to get cannibis off of the same classification as hard drugs. Have the feds get out of it and leave it up to the states. Cannibis was a non-issue before the late 1920s. Are you asking why the cops are concerned over busting people for possessing...
Child Support Criminal law not being enforced
A: Set up an appointment with your local State"s Attorney to discuss filing charges. If you need help getting the appointment, contact your local state representative or senator"s office to help facilitate the meeting, they should have an interest since they enacted the law. You are dealing with situation where they rarely use the law, and maybe even some prejudice about using criminal charges in " domestic" situations. 50% of all law enforcement officials are divorced and most are non-custodial parents. Be sure you have all your evidence ready to show the Sate"s Attorney, he/she will need proof of willful non-support to file charges. Willful non...
A: Hello Melissa, Of course I remember you, I have about you constantly since you first wrote to AllExperts And I know what you are facing is not easy. It is probably the hardest thing you will have ever to deal with. But you have take a beep breath and go to a teacher or school nurse, the principal or any law enforcement official. No matter how scared you are you need to go to one of these individuals. The reason is that they will help you. They will help you because they are required to help you. That is the law. Someone has to step in and protect you. You can not ignore the fact that the man that raped you is now threatening you. Melissa you need help and you need it now. People will believe you!!!!It does...
dating problems
A: Todd, DISCLAIMER: I AM NOT A lawYER or ATTORNEY. I am someone who has experience with family law issues, and am sharing my OPINION only. For the exact law as it pertains to your specific case contact a Professional Attorney in your area/county/country. Wow hard to read your question but bottom line if the 18 year is having sex with a minor whom is 16 in some states this is considered statutory rape. Check with a lawyer or law enforcement official in your local area to determine if this is the case. IF the child is NOT born yet, and no father has been determined legally Mom is the responsible parent. Kidnapping is not an issue but...
child sexual abuse issues
A: Leo, I"m sorry to hear about your struggles in being heard and having the sexual abuse crimes recognized by your family. This is one of the most critical issues that families must face and because of each of the victims/abusers own experiences, facing the subject is just more than most can bear. In regards to your "legal way to address child sexual abuse" after 10 years, I cannot comment, as I am not a lawyer or law enforcement official. Those laws vary from state to state, country to country. In many jurisdictions there are no limits on sexual crimes, but that apparently doesn"t apply in your locale. Because of the complexities of child abuse/sexual abuse in the minds of the...
Know we have a border problem so it takes no brains to recognise something must be done..but?
A: John Morton, who heads U.S. Immigration and Customs enforcement says that they will not support racist Arizona law He needs to be doing exactly what he is doing; his job. He is there to enforce federal immigration law; not placate the Bull Connors of Arizona in their attempt to turn all undocumented aliens into criminals. They are not. It is not a federal crime to be here without authorization. Look it up. The wonderful people of Arizona enacted this law making it a STATE crime to be in Arizona in violation of the federal immigration laws. Let the good people or Arizona pay to arrest, detain, prosecute and house in state prisons these horrible people who simply...
What Is a Health Code?
A: A health code is a series of local laws and regulations designed to protect public health. Health codes attach to a wide variety of activities and public services. It is the governing health code that sets immunization requirements for schoolchildren, establishes acceptable community water treatment processes, and obligates restaurants to keep their kitchens to a certain level of cleanliness, among other things. In most jurisdictions, health codes are propagated and enforced at the city or county level. They are designed to promote community welfare, and typically exist apart from regional or national health and safety laws.. In most cases, community welfare and public health is a concern of local legislators and elected
Guylaine Lanctot, M.D., "Vaccination, The Silent Genocide"
A: Vaccines Make Disease Remain and Grow (By Dr. Carley, M.D.) Inoculations causing VIDS (Vaccine Induced Diseases) AN EPIDEMIC OF GENOCIDE by Dr. Rebecca Carley, M.D. Court Qualified Expert in VIDS and Legal Abuse Syndrome "One basic truth can be used as a foundation for a mountain of lies, and if we dig down deep enough in the mountain of lies, and bring out that truth, to set it on top of the mountain of lies; the entire mountain of lies will crumble under the weight of that one truth. And there is nothing more devastating to a structure of lies than the revelation of the truth upon which the structure of lies was built, because the shock waves of the revelation of the truth reverberate, and continue to reverberate throughout the Earth for generations to follow, awakening even those...
How Do I Become a Peace Officer?
A: Requirements to become a peace officer may vary, depending on where the hiring organization is located. Typically, peace officers must complete employment application paperwork and submit to background and criminal record checks. Applicants usually have to complete training courses required in their jurisdictions and pass peace officer examinations. Interviews, physical exams, and psychological testing are often part of the process as well. There are many titles that may fall under the heading of peace officer. In many places, the term peace officer is used to mean a police officer. In other places, the term may be used to encompass a wide range of jobs related to law enforcement. As such, an individual hoping to become a peace officer will...
A: The most common ones are: 1. Decision-making for insurers. Many people are often denied health or life insurance, based on current medical conditions. Often, coverage is denied because of "pre-existing conditions", that is, some condition the person applying already has or had. Many times, this is used by insurance companies very blithely, without really checking to see if it is true. For instance, a person might be denied payment for a doctor''s visit for anything that included dizziness (such as a stroke), if in the past, they or a health professional had EVER used the word "dizziness" in a doctor''s visit! 2. Joining the Armed Forces or other branches of law enforcement: Most people know of the rating system in the...


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SOURCE: Peregrine Pharmaceuticals
June 03, 2013 08:25 ET
Interim Data Shows 85% Overall Response Rate With 15% Complete Response Rate in HER2-Negative MBC; Final Data From Company's Phase II Pancreatic Cancer Trial Shows Promising Overall Survival Trends Consistent With Immunotherapeutic Treatments
Interim Data Shows 85% Overall Response Rate With 15% Complete Response Rate in HER2-Negative MBC; Final Data From Company's Phase II Pancreatic Cancer Trial Shows Promising Overall Survival Trends Consistent With Immunotherapeutic Treatments
TUSTIN, CA--(Marketwired - Jun 3, 2013) - Peregrine Pharmaceuticals, Inc. (NASDAQ: PPHM) reported today that data was presented at the 2013 ASCO Annual Meeting from two clinical trials evaluating the company's lead clinical candidate bavituximab. In the first study presented, interim data from a Phase I trial evaluating bavituximab plus paclitaxel therapy in patients with HER2-negative metastatic breast cancer (MBC) showed that 85% of patients achieved an objective tumor response, including 15% of patients achieving a complete response (CR) measured in accordance with RECIST criteria.
In the second study, results from a randomized Phase II trial of bavituximab plus gemcitabine in patients with non-resectable Stage IV pancreatic cancer demonstrated more than a doubling of the overall response rate (ORR) and an improvement in overall survival (OS), including a delayed separation in the Kaplan-Meier survival curve that is commonly seen in clinical studies of promising cancer immunotherapies. These presentations were made at the 2013 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, Illinois.
"The results of this Phase I breast cancer trial are encouraging as there were no new safety signals and excellent clinical responses," said Alison Stopeck, MD, Associate Professor of Medicine and Director, Clinical Breast Cancer Program at the University of Arizona Cancer Center. "There were several laboratory correlative studies associated with the trial which confirmed the safety of bavituximab with regard to coagulation parameters."
In this open-label trial, 14 patients with HER2-negative MBC were treated with paclitaxel (80 mg/m2) weekly for three weeks of each four-week cycle and bavituximab (3 mg/kg) was administered weekly beginning on day 15 after two weekly doses of paclitaxel. Interim results from 13 evaluable patients showed that 11 patients (85%) achieved an objective response, including 2 patients (15%) that achieved a complete response (CR). In addition, the combination of bavituximab and paclitaxel was safe and well-tolerated.
"The data from this study strongly support advancing the program into later stage clinical studies in advanced breast cancer," said Joseph Shan, vice president of clinical and regulatory affairs of Peregrine. "In addition to the impressive overall response rate, we are also seeing interesting trends in correlative lab results which we are evaluating as potential biomarkers."
In the pancreatic cancer study, the final results from a company-sponsored, open-label, randomized Phase II clinical trial of bavituximab and gemcitabine in 70 patients with previously untreated, Stage IV pancreatic cancer continued to show encouraging activity in this patient population with very advanced disease. Results showed that the combination of bavituximab plus gemcitabine resulted in more than a doubling of overall response rates (ORR) and an improvement in overall survival (OS) when compared with gemcitabine alone (control arm). In the trial, 9 of 32 (28%) patients treated with a combination of bavituximab and gemcitabine achieved an objective tumor response as compared to 4 out of 31 (13%) in the control arm. Median OS, the primary endpoint of the trial, was 5.6 months for the bavituximab plus gemcitabine arm and 5.2 months for the control arm (hazard ratio = 0.75).
The trial included the enrollment of patients with advanced metastatic disease, including poor performance status (ECOG 2) and significant liver involvement associated with rapid disease progression. Results from a subgroup analysis showed that the effect of bavituximab plus gemcitabine was more pronounced in patients with ECOG ≤ 1 and those without hepatic metastases.
"We believe that these data coupled with the intriguing results from subgroup analyses shed light on the future development potential of bavituximab as part of the currently evolving treatment landscape of pancreatic cancer," said Kerstin Menander, M.D., Ph.D, head of medical oncology at Peregrine.
A copy of the posters can be found at www.peregrineinc.com.
About Bavituximab: A Targeted Immunotherapy
Bavituximab is a first-in-class phosphatidylserine (PS)-targeting monoclonal antibody that represents a new approach to treating cancer. PS is a highly immunosuppressive molecule usually located inside the membrane of healthy cells, but "flips" and becomes exposed on the outside of cells that line tumor blood vessels, causing the tumor to evade immune detection. Bavituximab targets PS and blocks this immunosuppressive signal, resulting in the maturation of dendritic cells and cancer-fighting (M1) macrophages leading to the development of cytotoxic T-cells that fight solid tumors. Bavituximab is the lead drug candidate from the company's PS-targeting technology platform and is currently being evaluated in several solid tumor indications, including non-small cell lung cancer, breast cancer, liver cancer and rectal cancer.
About Peregrine Pharmaceuticals, Inc.
Peregrine Pharmaceuticals, Inc. is a biopharmaceutical company with a portfolio of innovative monoclonal antibodies in clinical trials focused on the treatment and diagnosis of cancer. The company is pursuing multiple clinical programs in cancer with its lead product candidate bavituximab and novel brain cancer agent Cotara®. Peregrine also has in-house cGMP manufacturing capabilities through its wholly-owned subsidiary Avid Bioservices, Inc. (www.avidbio.com), which provides development and biomanufacturing services for both Peregrine and third-party customers. Additional information about Peregrine can be found at www.peregrineinc.com.
Safe Harbor Statement: Statements in this press release which are not purely historical, including statements regarding Peregrine Pharmaceuticals' intentions, hopes, beliefs, expectations, representations, projections, plans or predictions of the future are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. The forward-looking statements involve risks and uncertainties including, but not limited to, the risk that the the results of future trials of bavituximab and paclitaxel in patients with HER2-negative metastatic breast cancer may not be consistent with the results experienced in the Phase I trial company may not be able to initiate the Phase III trial within its anticipated timeline, the risk that the results from the Phase III trial may not support a future BLA submission, the risk that the company may not have or raise adequate financial resources to complete the Phase III trial and the risk that the company may not find a suitable partner for the Phase III trial or the PS program. It is important to note that the company's actual results could differ materially from those in any such forward-looking statements. Factors that could cause actual results to differ materially include, but are not limited to, uncertainties associated with completing preclinical and clinical trials for our technologies; the early stage of product development; the significant costs to develop our products as all of our products are currently in development, preclinical studies or clinical trials; obtaining additional financing to support our operations and the development of our products; obtaining regulatory approval for our technologies; anticipated timing of regulatory filings and the potential success in gaining regulatory approval and complying with governmental regulations applicable to our business. Our business could be affected by a number of other factors, including the risk factors listed from time to time in our reports filed with the Securities and Exchange Commission including, but not limited to, our annual report on Form 10-K for the fiscal year ended April 30, 2012 and our quarterly report on Form 10-Q for the quarter ended January 31, 2013. The company cautions investors not to place undue reliance on the forward-looking statements contained in this press release. Peregrine Pharmaceuticals, Inc. disclaims any obligation, and does not undertake to update or revise any forward-looking statements in this press release.
Christopher Keenan or Jay Carlson
Peregrine Pharmaceuticals, Inc.
(800) firstname.lastname@example.com
Christopher Keenan or Jay Carlson
Peregrine Pharmaceuticals, Inc.
(800) firstname.lastname@example.com
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Covering Philipstown, Cold Spring, Garrison and Putnam Valley in New York's Hudson Highlands
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Located in South Brittany, set in wild yet beautiful natural surroundings, Sofitel Quiberon Thalassa and Sofitel Quiberon Dietetique offer seawater spa treatments and mouthwatering cuisine from masterful chefs. Be inspired by the rejuvenating atmosphere of this timeless destination, where people and nature live in harmony. Experience the authentic French art de vivre with the best of views."
Each Sofitel draws inspiration from local culture and tradition while celebrating innovation and the French art de vivre to offer a one-of-a-kind, luxurious hotel experience. From design details to exhibitions and events, discover what makes our hotel so unique.
Rest in an atmosphere of elegance, pleasure and refinement in the bedrooms and suites of Sofitel Dietetique, havens of light and well-being. Each...Read more
Enjoy a magnifique a magical moment with your loved one at Sofitel Quiberon Thalassa sea spa! Book the "Magnifique Romance"...
We booked a Superior room with Ocean view and our view was indeed really excellent and contributed to the overall relaxing experience. As we arrived at the hotel, the concierge team sprang into...
We booked a Superior room with Ocean view and our view was indeed really excellent and contributed to the overall relaxing experience. As we arrived at the hotel, the concierge team sprang into...
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M odern science is full of surprising analytical techniques that can be used in a wide variety of remarkable circumstances.
y favorite technique is
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, the study of
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, and many others.
B elieve it or not, tree ring analysis has even been used to date wooden musical instruments like violins and cellos, and in at least one case, a double bass. The double bass is a member of the viol family and looks like a large cello, but it can produce sounds a full octave lower than a cello. Because of its size it is harder to play than its stringed-instrument cousins, so it is less commonly seen in orchestras and other musical ensembles. That is why it's not as well-known to the general public.
J ust over a decade ago, dendrochronologists analyzed tree rings in the wood from which the world-famous Karr-Koussevitzky double bass was made. Their work forced a radical reinterpretation of the instrument's history.
I n 1962, Russian-born philanthropist Olga Koussevitzky attended a performance of the New York Philharmonic in which Gary Karr, a promising young double bassist, offered his New York debut recital. Koussevitzky's late husband, who died more than 10 years earlier, was Serge Koussevitzky (1874–1951), conductor of the Boston Symphony Orchestra from 1924 to 1949 and arguably the most famous double bass player of all time.
M s. Koussevitzky claimed that during Karr's performance she saw her husband's ghost embrace the young man on stage. She was so moved by the experience that she decided to give her husband's prized double bass to Karr, thus leading to the Karr-Koussevitzky name for the instrument.
pon his retirement in 2004, Karr donated the double bass to the International Society of Bassists, and
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jumped into action to professionally evaluate the instrument for the first time. After analyzing stylistic and technological attributes, they suggested that the double bass dated to about 1800 and was probably from France. It was at this point that the tree ring experts got involved.
D endrochronologists Henri Grissino-Mayer and Georgina DeWeese, along with luthier Dustin Williams, conducted the analysis . They carefully secured the double bass to a movable platform so that they could safely measure the tree rings visible in the spruce wood used to make the instrument. Given its size—more than a meter long and 33 to 63 centimeters wide—this was not an easy task! They measured a total of 317 growth rings in two long, overlapping sequences in two of the many pieces of wood that make up the instrument. They then mathematically compared the measured ring-width data to known tree ring reference chronologies from across west-central Europe.
G rissino-Mayer and colleagues determined conclusively that the last growth ring present on the double bass grew in 1761. Based on their understanding of how spruce trees grow, and an estimate of the number of rings missing from the end of the sequence, they calculated that the tree from which the instrument's wood was taken had been cut down between 1775 and 1790.
S tatistically, the ring-width pattern from the double bass is most similar to growth patterns in trees growing in the eastern Alps. The pattern's strongest relationship is with tree ring chronologies developed near Obergergl in western Austria, just north of the Italian border, followed by Simmental in northern Austria and Berchtesgaden in extreme southeastern Germany.
F inally, Williams' stylistic and technological analysis of the instrument—and the fact that it was downsized at one point in its history—led him to conclude that it was made by French luthiers, using wood imported from Austria.
P rior to the tree ring analysis, unconfirmed and unwritten histories of the double bass held that the world-famous Amati brothers made it in Cremona, Italy, in 1611. Antonio and Girolamo Amati were the most renowned instrument makers of their day, and they remain famous for the quality of their workmanship and the prestige associated with their pedigree. (Girolamo's son Nicolò went on to train Antonio Stradivari, who created the famous Stradivarius violins.) It is therefore not surprising that previous owners of the Karr-Koussevitzky double bass would want to have the Amati brothers' name associated with the instrument, for its appraised value would skyrocket.
D endrochronology demonstrates conclusively that the Amati brothers cannot possibly have crafted the instrument in 1611. Indeed, the best we can say is that some unknown luthier made it at least 165 years later. Circumstantial evidence supports this conclusion as well: If the Amati brothers made the instrument, it would be the only known double bass in their oeuvre, which otherwise includes 77 violins, 27 violas, and 12 cellos.
M useum curators, appraisers, and private collectors spend a lot of time and money conducting provenance research in an effort to generate life histories and chronologies for specific objects under their care. They do so for good reason: Reliable provenance can demonstrate authenticity and legality, and can affect the monetary value of rare objects.
W hen the tree ring analysis forced a revision to the Karr-Koussevitzky double bass' history, it was likely disappointing to all parties concerned. The revised history doesn't affect the quality of the instrument or the sound it produces, but it certainly impugns the prestige associated with the object.
I n the big picture, though, more was gained than lost. Science is about finding the truth, and truth is more important than money and prestige put together.
Serge Koussevitzky, one of the most renowned double bass players of all time, died in 1951, but his instrument was given to double bassist Gary Karr in 1962. After that it became known as the Karr-Koussevitzky double bass.
When it comes to market-leading innovation, groundbreaking invention and out-and-out 'Oh my God I want one', Jaeger-LeCoultre and Breguet are among the best of the very best watchmakers in the world. These centuries-old timepiece tinkerers have contributed more to watchmaking than pretty much anyone else out there, moving technology forward in leaps and bounds, even today. The question that remains seems simple, but it'll take a whole lot of thinking to find the answer: which watchmaker is best? We take two contemporary masterpieces from each brand and pit them head to head to see which comes out on top.
Abraham-Louis Breguet, inventor of the tourbillon, developed the pioneering technology to negate the effects of gravity on the balance wheel by continuously rotating the whole thing. The watchmaker has had a bit of practice since 1801, so it goes without saying that it's good at it, but what about Jaeger-LeCoultre? How does its offering stack up against the masters?
The headline figure is the price. Utilising stainless steel for the case instead of precious metals, Jaeger-LeCoultre has accomplished something of a luxury bargain—a tourbillon for around £40,000. This isn't any cut-price Friday special either, because the same fantastic workmanship that Jaeger-LeCoultre uses in its range-topping Gyrotourbillon is present here in spades. Neat touches abound, such as the date hand, which jumps across the aperture in the dial so as not to obscure the tourbillon. Also, this tourbillon isn't manual wind, it's automatic, making it a sensible day-to-day proposition. But doesn't the rotor weight obscure the tourbillon assembly when viewed through the sapphire case back? The answer is no, because Jaeger-LeCoultre has cleverly cut a viewing hole in it.
The tourbillon—meaning 'whirlwind'—is a complication that spreads the force of gravity evenly over the balance wheel. It was originally designed for use in pocket watches, which spend most of the time hanging in the vertical position. The benefit in a wristwatch, which is generally more mobile, is minimal.
With the age of the mechanical watch now passed, the necessity to develop impressive and useful complications is more an opportunity to demonstrate technical ability than anything else. In a way, that opens to floodgates for some truly revolutionary thinking, as Breguet's Tradition 7047 demonstrates. In reality, the fusee and chain—the mechanism used here to keep a constant application of torque applied to the balance wheel—is no new idea, but the incredibly compact design takes the concept to a whole new extreme.
With links that are less than a millimetre thick, the chain in the Tradition 7047 is clearly the centrepiece, and that's an impressive feat when there's a tourbillon with a silicon balance spring and titanium balance wheel on show as well. The watch even has a power reserve indicator cleverly integrated into the mainspring barrel, and although all this wizardry doesn't leave any room for an auto-winding module, it's surprisingly svelte. Then again, this is no daily wearer, it's an art piece; the traditionally hand-guilloched dial takes up barely a quarter of the case and simply features two blued hands.
With fusee chain production at its peak in the 18th century, manufacturers turned to the orphanages to recruit their workers. Young girls, whose hands were small, were particularly suited to the job of producing the chains, some of which were slender enough to fit through the eye of a needle.
Jaeger-LeCoultre's Master case is home to a different beast here, namely the calibre 947, a minute repeater movement. Pull the lever on the left hand side of the case to its stop, release, and you will be treated to a combination of chimes that reveal the hours, quarter-hours and minutes. The 'code' takes a little while to figure out, but it's no matter, because watching the twin hammers strike their gongs through the skeletonised dial is very compelling.
Despite the case sharing much of its styling with its cheaper siblings, the feeling of luxury is far from compromised. The understated simplicity lets the sublime detailing do the talking and doesn't crowd the artisanal showpiece bristling under the dial. With the movement laid out back to front, the rear is not as interesting to look at as the dial side, but the decoration of what is there is stunning nonetheless. It's easy for watch manufacturers to make a mess of high complications in the attempt to put them front and centre, but Jaeger-LeCoultre doesn't fall for that. This is sheer, discreet class that rewards a keen eye with unsurpassable craftsmanship.
The minute repeater may seem like an unnecessary luxury today, but the complication did have its practical uses. As well as providing a means for visually impaired people to tell the time, it also served to aid time-curious users in an era before artificial lighting had become widespread.
At first, Breguet's 7800 simply looks to be a well-decorated three hander, but almost immediately questions are raised by the 48mm case size and the prolific use of musical notation in the decoration. The more astute will then also notice two little windows in the dial, not to mention the addition of a secondary crown and two pushers on the left hand side of the case. The explanation is simple, even if the execution is not: this a musical watch.
On the underside of the dial, pins are scattered in a seemingly disordered fashion, but one press of the top left pusher brings clarity. The intricately guilloched dial - a marvel in itself—begins to rotate, and the pins engage with a fifteen-toothed comb to play Rossini's 'The Thieving Magpie'. Being Breguet, there's some new tech in there too, including an array of magnets that manage wear and background noise from the mechanism, plus a Liquid metal membrane that amplifies the music.
This article started with a challenge, but it's clear that it's going to end in stalemate. It's a cop-out I know, but for every blow struck by one, the other parries, leaving neither with an advantage over the other. We're fortunate enough to live in a time where the collective centuries of these two old greats are beyond compare, and it would be borderline sacrilege to suggest that one was better than the other. Still, it was fun trying.
As well as a Liquidmetal membrane, Breguet utilises a series of slots in the caseback to amplify the sound produced by the calibre 0900. Impressively, despite it having several large holes in its case, Breguet have managed to give the 7800 a water resistance of thirty metres.
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1987 Mazda 626 GLX 2.0 Injection
Old, but excellent
At 160,000kms I had to replace fuel pump because old one brokes (it was stock!)
Seals start to fails (I hear wind while driving)
General Comments:
Maximum reliability, I made 15,000kms and except fuel pump I do only maintenance. Quite comfortable. Small issues because of age, not because quality of made. I have light interior and it's still light! Car in very good condition. Bravo to engineers from Mazda!
Would you buy another car from this manufacturer? Yes
Review Date: 5th February, 2006


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Includes the deliverables and reporting requirements of the project.
On 7 November 2006, the Prime Minister of Australia, the State Premiers of New South Wales, Victoria and South Australia, and the Acting Premier of Queensland, commissioned the consultant to 'report progressively by the end of 2007 on sustainable yields of surface and groundwater systems within the Murray Darling Basin, including an examination of assumptions about sustainable yields in light of changes in climate and other issues'.
There are three main deliverables:
- Development of a transparent, consistent and robust methodology for determining the extent of available water resources in each major catchment/aquifer, and the Murray Darling Basin (MDB) as a whole, including guidance on:
- how to adjust the historic flow records used in surface water models and the recharge assumptions used in groundwater models, to factor in climate change and other risks
- how to address the interaction between surface and groundwater systems
- identifying significant knowledge and information gaps.
- Application of the above methodology to estimate the quantity and temporal distribution of the water resources that are available in each major catchment/aquifer, and the Basin as a whole, having made any necessary adjustments to assumptions about climate or other risks.
- comparison of the new estimates of water resources with those identified as necessary to meet the levels of extractive use (current entitlements, security of supply and actual use) and to achieve the stated environmental and other public benefit outcomes of existing water sharing plans
- if there are catchments or aquifers within the Basin either without current water sharing plans or with plans for which environmental outcomes and/or levels of extractive use are not clear, these parameters will be inferred where possible using existing information (such as State water policies or existing regional NRM plans) and any assumptions clearly stated.
- Application of the above methodology to estimate water availability and demand 20 years into the future in the light of climate change and other risks
- comparison of the new estimates of future water resources with those identified as necessary to meet the levels of extractive use (current entitlements, security of supply and actual use) and to achieve the stated environmental and other public benefit outcomes of existing water sharing plans.
Three levels of reporting were envisaged as follows:
- Single page summary sheets that provide a graphical and tabulated summary of the predicted relative changes in water security and other indicators in the context of historical changes in water availability. These summaries will be produced for the entire basins and for each modelled catchment and are intended for non-technical audiences.
- Overview reports of ten pages or less (for the entire basin and each modelled catchment) that provide:
- contextual information regarding use availability and use in the area
- a summary of the assessed changes in surface water security; groundwater resource indicators and environmental flow indicators
- interpretative text that outline the potential implications of the results for the catchment.
- Technical appendices that provide for each reporting area all the supporting detailed technical results including time series plots, flow durations curves, allocation reliability diagrams and statistical analyses.
These reports:
- are likely to be large (50–100 pages per catchment) and intended for a technical audience
- will provide a complete legacy of the technical work of the project and provide the underpinning information on which the defensibility of the summarised results
- will fully document the audit trail of data and models which are used to produce the quantitative assessments of water availability and supply reliability.
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YOU GUYS!!! I can't hold back any longer, I'm so excited to share these ideas with you!
Hello lovely ladies! It's Jen, your Orange County photographer here at Hostess With The Mostess. I adore working with you and your families. You always trust me to come up with creative ideas, and execute the most stunning photo shoots (if you're looking for inspiration, head on over to my Facebook page, right here).
So today, I wanted to share with you a few simple ideas to help you create an amazingly awesome first year photo shoot of your own. Your little one only turns one year old once. So go big! Now I know it's likely you have an extravagant party planned already, but I encourage you to set some time aside a week or two before your party, and do a first birthday photo shoot of your own! Added bonus: you can display some of the photos at the birthday party! Scroll down to check out some sample shots, followed by tips for making the most of your own first year photo shoot.
1. Find a fun location.
Maybe an awesome wood or brick wall in your neighborhood. Or under a unique tree near your home. A cool iron gate, or a picket fence? The possibilities are endless!
2. Find a fun outfit.
For this shoot, we went with a tutu. And guess what, mom made it! Head over to Pinterest, and search "tulle tutu." You'll easily find simple instructions on how to create an inexpensive one your own!
3. Grab a special background.
I always love bunting. There are so many combinations you can use, and the colors always pop. You could also consider streamers, balloons, or so much more.
4. Bake a cake!
That's right, mama made this adorable cake, and it was perfect. We knew it would add a little fun to the end of our shoot, and make this little lady extra happy.
5. Incorporate your little one's personality.
Do they love when you to read to them? Bring some books to stack up. Do they love "playing" with a guitar? Put that in the background. Do they have a special toy that makes them laugh? Let them play with it!
6. Have some fun!
The pressure is off, there are no guests to entertain and no decorating to be done. So have fun with your little one. Make them laugh, make them smile. Genuine happiness cannot be duplicated, so let it shine through in your pictures.
7. Join in on the fun!
Don't be camera shy. I always encourage moms to be IN pictures with their kids (see some tips for doing that, right here). Bring a friend or a fellow mama, so they can take a few pictures for you. Don't pass up these moments to smile with your little love, they fly by fast!
And remember, you don't have to have a professional photographer like me, to do this for you. You can do it on your own, with a little will and effort! I hope this gives you lots of unique ideas and inspiration to celebrate your baby in an extra special way!
- Photography: Jen CYK Photography, Orange County, CA
- Bunting: A Fete Beckons
- Cake Stand: HomeGoods
- Cake & Tutu: Made with love by this Mama
8 responses to "Photography Tips for a Fun First Birthday Photo Shoot!"
Hi! Thanks for these! They're great! But what happened to tip #7? :)
No worries! Your image does say "8 tips" though. I was hoping it was a secret contest to see who was really reading. Haha!
Photography Tips for a Fun First Birthday Photo Shoot! http://t.co/VJaVFTDwCM
What kind of camera do you use?
Hi Eve!
Here is a post that tells about my gear. :)
With these tips, every mom can become a better photographer.
Hi! Thanks for these! This is awesome! :)