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Five things for pharma marketers to know: Friday, June 5June 05, 2015
FDA panel recommends approval of female Viagra; FDA says that Sanofi's and Regeneron's PCSK9 inhibitor lowers LDL; GSK cuts 350 jobs
Sun's FDA Warning LetterMay 21, 2014
The FDA's seven-page letter outlines some of the problems the regulator has with one specific Sun site.
Sun Pharma to buy RanbaxyApril 07, 2014
The announcement will create the fifth largest generics drug maker, reports Reuters.
Ranbaxy shuts two sitesFebruary 25, 2014
The drugmaker says the voluntary measure was out of an abundance of caution.
FDA's Hamburg says India is a significant pharma partnerFebruary 24, 2014
The FDA commissioner said the agency is doing its job, not picking a fight, when it inspects drug-making facilities, and that India must take an active role for a harmonious supply chain.
More Ranbaxy woesJanuary 13, 2014
The FDA finds problems at another plant.
Boehringer shutters problematic Ohio plantOctober 07, 2013
1,100 workers will lose their jobs at a plant with a history of around 40 recalls.
Business briefs: Akorn, Bayer, Lonza, plus curbing CNS drug useAugust 27, 2013
Akorn expands, buying Hi-Tech Pharmacal; nursing homes miss their goal to curb antipsychotic-drug use; Bayer cancer drug gets priority review; and Lonza lays off staff
Business briefs: Teva, AbbVie, Novartis, WockhardtJuly 24, 2013
FDA grants Teva three years exclusivity to sell Plan B OTC for all ages; FDA gives Humira a thumbs-down for spondyloarthritis; a UK vaccine committee rejects Novartis' meningitis B shot; and Wockhardt gets a warning letter from FDA for its manufacturing practices at an Indian plant.
FDA pushes Merck's suvorexant asideJuly 01, 2013
The regulator says Merck needs to focus on lower doses of the drug.
Business briefs: Bayer, FDA, RanbaxyMay 15, 2013
Bayer's prostate cancer drug clears FDA three months early; a House committee is pressing the regulator for employment transparancy; and Ranbaxy takes a multi-million dollar hit over violations
Navidea deploying MSLs in launch of new diagnostic agentMay 02, 2013
Medical science liaisons will educate nuclear-medicine clinicians as part of the launch of a new Navidea diagnostic agent for use in breast and skin cancer.
Excedrin relaunch features Sparks, "Thank yous" from migraine sufferersNovember 21, 2012
Novartis is hyping its relaunch of Excedrin with a celebrity spokesperson, a migraine app and a survey of women migraine sufferers - along with print and out-of-home ads, radio promotions, direct mail and social media.
Company news: Eli Lilly and NovartisOctober 31, 2012
Eli Lilly to add manufacturing capacity in Indianapolis, Novartis invests more in Singapore
Op/Ed: Meningitis crisis and the threat to pharmaOctober 10, 2012
The deadly meningitis outbreak highlights the threat not only to public health, but also to the pharma industry, posed by the largely unregulated practice of pharmacy compounding.
Company news: UBM Medica, Bristol-Myers SquibbJuly 11, 2012
UBM Medica adds a third iPad app, BMS expands in Puerto Rico.
Company news: GlaxoSmithKline, AstraZeneca, Nature PublishingMarch 22, 2012
GlaxoSmithKline is building its first new UK factory in almost 40 years, the firm said, spurring jobs while breaking new ground at some of its current locations.
Sanofi braces for patent cliff impactFebruary 09, 2012
Sanofi is girding itself for an ugly year, forecasting a 12%-15% drop in business earnings per share for 2012 as the company absorbs the loss of patent exclusivity on a stable of drugs that brought in more than €4 billion last year.
J&J says no shakeup at McNeil Consumer Healthcare unitFebruary 01, 2012
J&J is pushing back hard against a Wall Street Journal article suggesting that a pair of retirements and a promotion are part of a corporate shakeup of its recall-plagued McNeil Consumer Healthcare division.


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Britain has had some quirky and odd industries in the last century, but few were as typically strangely British as some factories mostly staffed by women who manufactured punishment canes for use in schools, prisons, reformatories or even for use at home by many British parents at one time. All through the nineteen hundreds, punishment canes were frequently used in schools, reformatories and even homes up until the 1960's and 70's when new education legislation began to view this very painful punishment as abusive rather than an effective teaching tool.
Some teachers in the UK are lamenting about the abolition of the use of corporal punishment in British schools because with this powerful deterrent to bad behavior gone, behavior in British schools has only grown much worse they now claim, where now 1/3 of all teachers report being punched or physically assaulted by their students, and students skipping class or bringing contraband to school such as weapons or drugs has only greatly increased. And while the late 70's punk rock era in British music created some creative new music, it probably only promoted more lawless and violent behavior in the British school system after the deterrent of a stiff caning was outlawed by newer government legislation.
Some social polling sites such as Mister Poll have many polls, including some from those over in the UK who once received canings in British schools in the old days. They all remarked about the terrible pain created by this dreaded spanking instrument that seemed to be most uniquely British in use, although some nations like Singapore and in the Muslim Mideast the use of canes is still common. According to Wikipedia, near the end of school season in Singapore with final exams, many merchants still sell canes to parents who may later whip their high school aged children who do poorly on their final exams, providing a very powerful deterrent to not studying hard to get a good grade. According to one recent survey, 57 out of 100 parents in Singapore had punished their kids at least one time by caning. Compared to many U.S. kids getting grounded at worse for crummy school grades, that's some tough love.
First in Scotland in 2003, and finally in the UK in general in 2011, new legislation came into play that made illegal to use any implement that would cause a mark on a child. That was sure contrary to why the cane was such a powerful deterrent to bad behavior. The instrument was designed to leave painful marks, or welts from the cane strokes that would throb or to be sore for days to remind a culprit of their wrongdoing. In British schools, the painful instrument could be used on most students of any age at one time. However, at home, many parents would use this instrument to punish their older teenagers, say a 18 or 19 year old boy or girl, who were too old for handspanking, but required some punishment that would significantly hurt them despite their older age and bring them to tears and repentance. Canes of different grades such as junior and senior and judicial ones once existed. The judicial model was used in prisons or reform schools, while the senior model was reserved for older students in the British school system since it could even penetrate through layers of clothes to cause great pain. The junior version was also popular in schools for younger students, but was once the choice of many parents for the home in the UK because most home punishments were often likely given on the bare skin as a form of extreme spanking for older children in their late teens. Generally 6-12 strokes was pretty common in either British schools or the British home, and seen as legally acceptable at one time.
Today, such instruments seem barbaric and medieval. But, mostly still have some use among those adults into the S&M scene who dig the kinky theatrics of these dreaded classic classroom discipline instruments. But, looking back, you had to wonder what was going through the minds of those women producing those painful canes in that old British factory. While the instruments might be doing some good for society by keeping order in schools, in reformatories or even at home, they weren't going to do much good to some offender's backside. They were one of the few consumer products that when used as intended would cause the consumer great pain.
Not much is known about when rattan first came into use as a discipline instrument, but women in the old British factories that made these instruments used to steam and bend part of the rattan to create a rounded end much like a walking cane handle. However, the extremely whippy nature of the rattan made these totally unsuitable for use as a walking cane, where these special type of canes had only one purpose, and that was to be used as a punishment instrument.
Strangely, canes actually came into use in Britain probably in the very late 1800's or almost 1900's when as a form of reform in corporal punishment in the school system. Birching, or the use of a handful of twigs or switches was most common in use before that, but would often cut the skin and cause some superficial bleeding on the bare skin, and the heavier cane could even be used effectively over some layers of clothes and cause sufficient punishment to wrongdoers. Canes were viewed as being more modest because bare skin wasn't required to punish a student.
Students in the U.S. can be pretty glad that the American school system used a lot less physical discipline than the British counterpart. However, as a young student in Roman Catholic grade schools I still remember some bad students getting a yardstick whipping from the Mother Superior in the back of the classroom as a kid in the early 1960's.
At any rate, this old photo spurred an interesting discussion between me and my friend from the UK who lectures widely on ending abuse as a medical professional. At one time the use of canes were very acceptable in the UK, but that's not to say that a great many wrongs happened as a result of the use of these dreaded instruments. The use of such instruments sure seems draconian by today's standards, and rightly so. Instruments like this have no rightful place in the schools. But among adults, the cane will probably remain popular as a form of S&M prop for many years to come. What consenting adults do is a whole different thing than what used to take place in the British school system.
Yet, somehow this old business of producing canes to hurt people seems like a literal pain in the ass. But, at one time cane producing companies in the UK probably made a lot of money, with plenty of schools, prisons, reformatories and even more than a few angry parents as customers. That was the bad old days.

subset: commoncrawl


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The art of life lies deep embedded to the spirits within, and the beauty of it, carefully engraved over the inner-sense of our souls. We live a timid life where happiness is defined by the degree of compromise and sacrifice one can endure, and the pursuit of true serenity of self-content, remains undone. But now, it's time to loosen the ties and shed all complicacies, and head out of this concrete jungle …into the wild! Enjoy the colors & spirits around! Learn to appreciate the beauties of the Bengal.
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Copyright© 2011-2018 | Magnificent Bangladesh | All rights reserved.


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School students will get a first-hand look at Pennsylvania Amish culture on a class trip to the Amish Village in Lancaster County.
Visiting the Amish Village is a great way for school students to learn about a culture that has remained relatively unchanged in nearly 300 years. Our staff will help you plan the details of your field trip and make sure your kids get the most out of their educational experience.
We can accommodate multiple busloads of students, and you'll find our staff easy to work with. They will be happy to tailor a class trip to fit the needs of any group of students. Just contact our office and we can help plan your trip to the Amish Village.
Student tours and class trips start out with a 25-minute guided tour of our authentic Amish Farmhouse, where a local tour guide will explain the history, culture and religious traditions of the Amish in Pennsylvania. While our student tours are geared to the entire K-12 age range, our guides can easily tailor the tour for either younger or older students.
At the conclusion of the Amish house tour, your local guide will escort the students as they explore the rest of our property. During this time, students can ask questions about the Amish lifestyle today while they explore our 12-acre Village Grounds. During your visit, you'll always have someone on hand to answer questions and enrich the students' Amish experience.
Plan Something Special for Your Students
Teachers and school administrators who have something specific in mind for a trip to Amish Country should be sure to contact us to discuss their plans. Whether it involves spending time with the farm animals at the barn, or a unique teaching experience in our one-room schoolhouse, we're happy to customize a Lancaster County Amish experience just for your students.
You can even send outlines and curriculum ideas to our staff, and together we'll develop the perfect class trip for you and your students. Just be sure to leave enough time to work with us to plan your visit. Generally, 2 weeks is required to customize a student tour or class trip.
Groups must be 20 students or more, and will receive discounted pricing from the standard admission. Pricing is based on the time of year and any specific needs or requests your class may have. Contact us for specific rates for your student tour or class trip.
School Tour Details
Amish House Tour, 25 minutes
Property Tour, 30 minutes
Customized Experience, based on activity
School Groups:
Students (K-5) $5.75
Students (6-12) $6.75
Student tours must be scheduled in advance, generally two weeks prior to arrival. Teachers and school administrators can call 717-687-8511 or contact us online to reserve a tour time prior to your arrival in Lancaster County (deposits are required).
|Tour Rates:
Discounts apply to classes with 20 or more students. Contact our offices for specific rates.


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2016-17: Ran in three meets during the cross country season…Kicked off the season with an eighth place finish in the 4K at the Duke Alumni Meet (9/2)…Ran a personal best time of 25:57.7 in the 6K at the Roy Griak Invitational (9/24)…Did not compete during the indoor or outdoor campaigns.
Prior to Duke: Lettered all four years under the guidance of Stan Lambros and Karen Scott at Cheyenne Mountain High School in Colorado Springs, Colo…four-time Pikes Peak Athletic Conference (PPAC) first team honoree…crowned the 2016 cross country Rotary champion…graduated as the 1,600 meter school record holder…named the Cheyenne Mountain Scholar Athlete of the Year…earned AP Honors with Distinction…member of the President's Honor Roll…claimed Academic All-State first team recognition…participated in the Science Olympiad, National Honor Society, French National Honor Society and Students and Teachers Aiding Humanity, among other organizations and clubs.
Personal: Daughter of Sergio de Lourenco and Anne Brtek…born April 28, 1998…has one brother, Daniel, and one sister, Aviana.
Cross Country PRs
5K- 18:30 (High School)
Outdoor PRs
800m- 2:18 (High School)
1,600m- 5:09 (High School)


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The Phelps County Regional Medical Center (PCRMC) health system serves as the regional hub for referrals in south central Missouri and provides its 6-county service area of over 200,000 patients with state-of-the-art technology, medical equipment and a world-class physicians group.
Rolla is a robust college town and has been voted as one of the best small towns in America. Missouri University of Science and Technology (Missouri S&T) has an enrollment of over 7,000 students from all 50 states and over 50 foreign countries.
BC/BE Psychiatrist to join our established team.
Opportunity for BC/BE Neurologist to join 240-bed nonprofit hospital.


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Pleasure Cove Resort and Marina is one of California's largest bodies of fresh water, and with over 165 miles of shoreline, Lake Berryessa offers year-round recreation opportunities for the whole family. Nestled between Blue Ridge and Cedar Roughs, and just east of the Napa Valley, Lake Berryessa is a popular recreation destination for over 1.5 million visitors each year.
Summer water temperatures reach 75 degrees, making Berryessa the perfect destination for water sports. The lake is also a popular fishing location for both cold and warm water species. Pleasure Cove Marina operates from the south end of the lake just off highway 128, and provides houseboat rentals as well as other marina services. With an assortment of activities that the lake and surrounding area has to offer, you'll find exactly what you're looking for at Pleasure Cove Marina on Lake Berressea. Whether you're a first-time visitor or one of our returning guests, we look forward to seeing you out on the water.
Receive a $200 discount off of their houseboat rental and/or a 10% discount off powerboats, personal watercraft and other small boats.Learn More & Book
Valid documentation required upon arrival and check in. (Not required to be the primary name on the invoice)
Cannot be combined with other specials or offers. Offer expires on December 31, 2018. All other Houseboat Rental Terms and Conditions Apply.Learn More & Book
"Choose Your Fun" on your next houseboat vacation! With this special offer, receive a $300 fuel credit or $300 off your houseboat rental.Learn More & Book
"Choose Your Fun" on your next houseboat vacation! With this special offer, receive a $300 fuel credit or $300 off your houseboat rental. Want to take advantage of these kind of savings?
Call us today at (800) 255-5561 to find out all the details!
Thank you for coming back! We know each memory on the lake is even more special than the last.Learn More & Book
Thank you for coming back! We know each memory on the lake is even more special than the last. Let us show our appreciation to you, by guaranteeing the best discounts to our returning customers. Call us at 1-800-255-5561 today to reveal your greatest savings!
Save this summer and book your next houseboat vacation! With this special offer you can now save up to $500 off your Houseboat Rental and 15% off a small boat.Learn More & Book
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(Montclair, NJ –May 26, 2016) HackensackUMC Mountainside will celebrate 125 years with the community on Saturday, June 4th beginning at 2pm in the Bayberry. All are welcome to attend this open house event to honor the history of Mountainside and to acknowledge the many babies born at this facility throughout the decades. Guests are encouraged to take a picture in the photo booth to commemorate this memorable occasion. Raffle prizes, refreshments and free parking will be provided.
If you were born at HackensackUMC Mountainside and you'd like to participate in the baby photo collage display, go to www.mountainsidehosp.com/125to upload your photo.
To RSVP for the event, please call 888-973-4674.
About HackensackUMC Mountainside
HackensackUMC Mountainside has been serving Montclair and its surrounding New Jersey communities since 1891. The hospital, part of the Hackensack University Health Network, provides patients immediate access to innovative and effective treatment alternatives at specialized centers within the hospital that focus on imaging, women's health, cancer care, surgery, obesity, stroke and chronic kidney disease. HackensackUMC Mountainside is designated as a Primary Stroke Center by the NJ State Department of Health and Senior Services and is one of only a few community hospitals licensed by the State to perform emergency cardiac angioplasty. To learn more about HackensackUMC Mountainside visit www.mountainsidehosp.com


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Evan Peters Rests His Hand on Fiancee Emma Roberts' Head
Evan Peters places his hand on top of his fiancee Emma Roberts while going shopping at a local market on Sunday (March 9) in Hollywood.
The 27-year-old actor recently talked about how he and Emma both had crushes on each other while filming Adult World.
"Well, I had a crush on her, too, and I didn't really know how to approach her or talk to her or any of that stuff," Evan told Vulture. "And at the time I was a more introverted actor, trying to kind of stay into it and stay focused and not talk too much. But, yeah, I tried to talk to her a few times and, I don't know, I kept saying the wrong thing. I was really kind of awkward and stupid and like, Oh God, this is just not working out well. I'm just going to shut up and not talk."
FYI: Emma is wearing a StyleMint tee. Evan is wearing a Junk Food Clothing t-shirt.


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To reserve vacation rentals in Crystal Beach, Texas, visit VRBO.com or FlipKey.com, browse Crystal Beach property listings, select a property, and either complete an online booking form or email the owner to check availability and booking procedures. Local rental company Cobb Real Estate also offers a 24-hour online booking service, while RE/MAX On The Water Vacation Rentals offers customers an online contact form and a telephone number.Continue Reading
VRBO offers a secure online booking and payment service for vacation rentals through HomeAway Payments. To reserve a property using this system, search for properties that have a Request to Book or Book Now button. Complete the booking form with arrival and departure dates and number of guests, enter payment information, and submit the request. You receive a booking confirmation number, and if the property owner accepts your booking, your card is charged within 24 hours along with a confirmation email. VRBO offers advice on paying securely for a vacation rental in its FAQ section.
FlipKey offers a similar secure payment system with a Peace of Mind Guarantee for bookings made through FlipKey Payments. To make a booking, complete the online form on the vacation rental page, and click Request Booking. Enter credit card details, or pay with PayPal. You are not charged if the owner declines your booking or does not respond within 24 hours.Learn more about Geography


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The stunning Milano 1800mm roll top freestanding bath is sure to make a statement in a traditional bathroom. Featuring an elegant and timeless design, this double ended freestanding bath incorporates plenty of bathing space to ensure a truly relaxing bathing experience. The central tap platform means that there need be no more arguments over 'who gets the tap end!'
The freestanding bath has a high quality acrylic construction. It includes the stylish feet as shown - please choose which feet you require.
Please note: taps and waste not supplied.
N.B. Other waste and trap arrangements may not fit the freestanding bath.
Milano Freestanding Roll Top Bath Features:
|Volume (litres)
|Tap Holes
|Thickness (mm)
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|10 Years
To see a 360° product view in full screen click on the icon on the right.
We bought the Milano bath without tap holes and the finish of the
bath is good quality workmanship I rate this bath 5 star
Reviewed by Henry Evans on 29 September 2016
Great bath,worth the money for those who are on
a budget.
Reviewed by Anonymous on 12 August 2006
Excellent product. we painted the outside to match our one coloured wall in the bathroom, looks great.
Reviewed by P Miley on 17 May 2006
A great bath excellent quality the ball and claw feet look great, worth the money
Reviewed by a rudd on 23 April 2006
Have you purchased the Milano 1800mm Freestanding Bath? If so we'd love to know what you think of it.
Additional charges may be applicable to Highlands, Lowlands and Islands – Learn More
This product is typically dispatched by pallet and takes up to 5 working days to arrive. In order to arrange this delivery you will be telephoned by the courier. Please be aware that your purchase will be delivered and left at your agreed address on the pallet. Any arrangement to transport your purchase after delivery is the responsibility of the customer.
Here at BigBathroomShop.co.uk we operate a 14 days return policy, so if you are not completely satisfied with your purchase(s) you'll be able to return it within 14 days of its delivery.
To speak with a member of our customer services team call 0345 122 7569 (dial +44 345 122 7569 for calls made from outside the UK).
Our hotline is open Monday to Thursday 8.30am to 9pm. Friday and Saturday 8.30am to 5pm. Sunday Closed. Full details of our returns policy can be found here.


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Glass Votive Holder - Pink Rose Smash
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A sumptuous ornament for your votive and tealight candles, this Pink Rose Smash Votive Holder is a striking accessory to add a touch of glamour to your home.
An opulent piece, this candle accessory is beautifully finished with glass smash mosaic that reflects the light. Heavy duty and durable, this piece is ideal for restaurants and venues, parties, weddings and garden displays. A decadent touch, perfect for any decor.
Stylish and practical, Votive Holders shield the candle flame from droughts and protect your furniture from hot wax and heat. A fantastic way to decorate the home and garden.
This candle holder makes a beautiful gift, especially when wrapped up with a few Yankee Scented Votives of your choice.
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Call: (877) 991-9922 or Email: firstname.lastname@example.com
A resourceful lad, he had the idea of roasting several kinds of high-quality coffee beans separately before blending them – an intricate, labor-intensive modus operandi rarely used then or now – in his mother's kitchen.
Joe maximized flavor by discovering and using the ideal roast for each particular type of bean. The formula was an immediate success. The coffee aroma emanating from Joe's cart as he made his popular door-to-door deliveries gave birth, word has it, to the expression "Cup of Joe."
In 1908, Joe bought his first small factory and began marketing his premium blend to hotels and restaurants. Soon after, he packaged the ground coffee in cans and sold it to stores.
Joe was a pioneer in marketing. He bought a small fleet of Rolls Royces in the 1930s and painted the Martinson logo on them. He had the back seats removed and sent out salesmen and delivery guys dressed as chauffeurs to deliver the coffee to upscale hotels and restaurants in Manhattan. Ahead of his time, the clever entrepreneur also used small airplanes to streak across the Big Apple skyline trailing banners and served free coffee on Wall Street in the thick of winter from a Martinson bus.
Coffee grows best in an area known as the Bean Belt -the band around the Earth in between the Tropics of Capricorn and Cancer.
The tasting of coffee is referred to as "cupping". The tasting of coffee is a rigorous and disciplined process.
The process of roasting which can use convection, radiation or conduction, in various combinations, is the application of thermal energy which initiates physical and chemical changes within coffee beans. During roasting, sugars combine with amino acids, peptides and proteins in a caramelization process called Maillard's reaction, responsible for many of the health benefits of coffee that continue to be discovered. The resulting roast may contain more than 1,000 different compunds affecting flavor and aroma!
Due to insignificant nutritional values, coffee is exempt from nutritional labeling. Coffee is the only ingredient.
No more than 3% caffeine remains in decaffeinated coffee as per US regulations.
The Rainforest Alliance Certified™ seal supports environmental, social and economic sustainability. Certification is awarded to farms which meet comprehensive standards, which includes providing habitats in which plant and animal-life can thrive, while providing farmers and their families with resources and support to sustain their livelihood.


text: THE DECISION OF former Jacksonville state Rep. Steve Pajcic to resign his House seat to campaign for next year's Democratic Party governor nomination has prompted a flurry of contenders for his old post, including City Council President Bill Carter. Because District 15 is heavily Democratic, Republicans are being cautious about how big an effort they will make. House Minority Leader Dale Patchett, R-Vero Beach, said that with the right candidate the GOP may make a big push because of potential crossover Democratic voters. In 1984 President Reagan won the district 18,000 to 11,000.


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National Wildlife Health Center
...advancing wildlife and ecosystem health
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USGS scientists have isolated ranaviruses associated with die-offs involving more than 20 species of amphibians and turtles.
Massive die-offs of amphibians are often caused by ranaviruses. USGS scientists have isolated ranaviruses associated with die-offs in over 25 states involving more than 20 species of turtles and amphibians in mortality events ranging from one to thousands of individuals affected. Some events may involve a single species, others may involve multiple species. Frogs and salamanders in the same pond, for example, may die from ranaviral infections at the same time.
Ranavirus-caused die-offs in amphibians have occurred on private, State, and Federal lands, including several National Parks and Wildlife Refuges. Many of the amphibian species involved in die-offs are fairly common and widespread in the United States, but some are either declining in number or are already threatened or endangered.
Host species: The USGS National Wildlife Health Center has isolated amphibian ranaviruses from 16 species of frogs, one species of toad and six species of salamanders. Mortality events due to ranaviruses occur most commonly in larval amphibians such as mole salamanders (Ambystoma spp.), true frogs (Lithobates spp. and Rana spp.) and chorus frogs (Pseudacris spp.). Infrequent isolates have been obtained from adult newts (Notophthalmus viridescens), adult tree frogs (Hyla spp.) and post-metamorphic Columbia spotted frogs (Lithobates luteiventris). In states east of the Mississippi River, especially Atlantic coastal states, mortality events tend to involve all species within the wetland (frogs, toads and salamanders) while those in western states, with less amphibian species diversity, tend to involve only one species.
Ranavirus infections in turtles occur mostly in captive colonies of eastern box turtles (Terrapene carolina carolina) and true tortoises, but die-offs of free-ranging box turtles also have been observed. Because box turtles in the wild usually are solitary animals, it has been difficult to document die-offs of multiple box turtles from an area.
Distribution: Amphibian ranaviruses probably are present in every state with the possible exception of Hawai'i. Globally, ranavirus diseases in amphibians have been diagnosed in North and South America, Europe, Asia, and Australia.
All confirmed cases of ranaviral infection in wild eastern box turtles on file at the USGS NWHC are from Maryland. Most of the affected turtles came from a single field study site. Additional ranaviral disease outbreaks in box turtles have been reported by others in New York, Pennsylvania, Georgia, and Florida. Unexplained die-offs of wild box turtles with signs resembling ranaviral infection, although not confirmed, have been reported in Virginia and North Carolina.
Seasonality: Because mortality events due to ranaviruses mostly affect larval amphibians, there is a strong correlation between the presence of amphibian larvae in the spring and summer with ranaviral die-offs. Mortality events often are first detected in April when large populations of wood frogs (Lithobates sylvaticus, formerly Rana sylvatica) are present in eastern and northern wetlands. Early and mid-summer die-offs due to ranaviruses tend to involve a variety of amphibian species nationwide. Late summer and autumn mortality events involve mostly larval bullfrogs (Lithobates catesbeianus) and tiger salamanders (Ambystoma tigrinum).
Cause/Etiology: Ranaviruses are DNA-based viruses of the genus Ranavirus, in the family Iridoviridae. Occasionally, amphibian ranaviruses are called iridoviruses; however, this can be confusing because there is a genus of insect viruses called Iridovirus. Some isolates of amphibian ranaviruses have been named; most noteworthy are Frog Virus-3 (FV-3), first isolated in the 1960s, and Ambystoma tigrinum (tiger salamander) Ranavirus. Other strains or isolates of ranaviruses have informal names (e.g., Bohle virus in Australia, Redwood Creek virus in northern California, Southern High Plains virus, etc.), but the status of most isolates as species or strains of Ranavirus has yet to be clarified.
Signs and Lesions: Field signs of a ranaviral epizootic include sudden or explosive onset of illness in amphibians in a wetland, often with hundreds or thousands of sick and dead amphibians found in a 1–5 day period. Overall mortality rates in juvenile frogs and salamanders in a wetland can exceed 90%. Affected individuals usually present with subtle to severe hemorrhages in the ventral skin, especially at the base of the hind limbs and around the vent opening. Hemorrhages may be present from tip of chin to tip of tail ventrally and may be pinpoint or irregular patches.
Other clinical signs include lethargy, swimming erratically, weakly, or on their sides, and mild to severe fluid accumulation under the skin (in lymphatic sacs) of the abdomen and proximal hind limbs. Internally, there may be fluid accumulation (clear or red-tinged) in the body cavity (called hydrocoelom), and hemorrhages on the serosal surfaces of viscera, especially heart, stomach and liver. Occasionally, white minute foci of necrosis are evident in the liver or spleen. Ulcers of the skin and palate tend to be randomly scattered, but are detected in a low percentage of casualties.
Turtles with ranavirus infection show weakness, swollen eyelids, discharge from the nose and mouth, and the tongue and palate may show dull white or thick yellow plaques. At dissection, these plaques also may be found in the pharynx and esophagus. Occasionally, turtles may show ulcers on the bottom of their feet. Like ranaviral infections in tadpoles and salamanders, infection in box turtles spreads throughout the body affecting many organs including blood vessels. Additional research is needed to determine whether ranaviruses from box turtles and amphibians are identical and may be transmitted between the different genera and species.
Significance/Zoonotic Risk: At present, ranaviral infections appear to be limited to ectothermic vertebrates (i.e., fish, amphibians and reptiles). The virus generally cannot be cultured at temperatures above 30oC, so it probably is not infectious to domestic mammals and humans. At present, it is unclear how many strains or species of ranavirus are infecting and killing amphibians and turtles. Ranaviral outbreaks involving more than one class of vertebrates (i.e., fish and amphibians, or amphibians and reptiles) at a site are rarely reported in the wild, but such mortality events are of great interest ecologically. Ongoing research by USGS scientists and others will help to determine whether die-offs due to ranavirus are causing or contributing to population declines in turtles and amphibians.
For more information please contact: The USGS National Wildlife Health Center, at 608-270-2400.
Policies and Notices
U.S. Department of the Interior | U.S. Geological Survey
URL: http://www.nwhc.usgs.gov
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Jun 20, 2018


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From 1373 to 1438 and father of Albrecht III 'der Fromme',
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Defect and Photo Albums
The photographs provided on the CDs are a resource for training workshops and general educational events. The images are also ideal for use in training manuals and illustrating technical articles and text books. The photographs are provided royalty free provided they are not resold as individual images or as part of a image library.


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Panda Cub Born at National Zoo
This just in from the Panda News Desk at the National Zoo. Mei Xiang, the zoo's 14-year-old female giant panda, was seen giving birth on the panda camera a little after 10:45 p.m. on Sunday night.
So far, mom and baby seem to be doing well. Zoo officials noted that they'll keep their distance unless they get an indication something is wrong.
"This is still a very, very precarious situation," said National Zoo Director Dennis Kelly. "This particular animal is very, very small, and we're going to watch it very carefully."
According to the Washington Post, Mei has had five consecutive false pregnancies since 2007, so the birth came as a surprise to them, as her chances of becoming pregnant had fallen to less than 10 percent.


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Atomic Robo-Kid (Genesis) review
"Where to begin? ABK's faults read like a grocery list--of spoiled items. Your character, an annoyingly cute R2-D2 wannabe, is too large and clunky and slow. What this amounts to is having to drag your excruciatingly lethargic metallic carcass around until you manage to earn a speed up icon. Without one, you won't stand a chance. To that point, allow me to fast forward to the site of the game's supreme manifestation of this greatest flaw, a sticking point that is almost laughable in its hideousness. "
Staff review by Marc Golding (October 09, 2004)
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Grayslake, IL Event
October 13, 2018
Find Your Greatness
Great habits create great lives. What are your habits? Are they helping you become the-best-version-of-yourself? Join us for Find Your Greatness to discover the four habits that will radically transform your life . . . and re-energize your parish.
About the Event
Our lives change when our habits change. Based on Matthew Kelly's book The Four Signs of a Dynamic Catholic, Find Your Greatness will introduce you to four simple ways to reach your full potential. This half-day event features live music and includes a free bag of Dynamic Catholic resources for every attendee.
Event Information
- Speaker
- Dr. Allen Hunt
- Location
- St. Gilbert Parish
- 301 E. Belvidere Rd.
- Grayslake, IL 60030
- Date
- October 13, 2018
- Time
Doors open an hour before the event. We recommend you arrive at least a half hour before the start of the event to collect your event materials and find a seat. For a more prayerful experience for everyone, please silence your cell phone when the event starts and refrain from taking photos and videos. This event is not recommended for children under ten.
Every event attendee will receive an event bag, which contains a book, CD, journal, pen, and several other great resources. Please note, meals are not served during the breaks, feel free to pack a snack to enjoy during the breaks in public areas.
What's Included With Your Ticket
Every person receives a free event bag with the following items:
- The Four Signs of a Dynamic Catholic *
- Inspirational journal
- Dynamic Catholic pen GET TICKETS


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Unsurpassable Hong Kong accommodations can be found at the Regal Kowloon Hotel. Guests can choose from 600 well-appointed guestrooms, including 38 suites, each with a look of modern grace and elegance reflecting a commitment to provide the most satisfying level of hospitality.
Additional Features
- 24-hour room service
- In-room safe
- Non-smoking rooms
- Safe deposit box
- Child care
- Business center
- Complimentary shoeshine services
- Foreign exchange service
- Gym
- La Terrasse, the hotel's garden
- Limousine services
- Airport shuttle bus transfer


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Innovating for You
VICTIG as a consumer reporting agency has developed innovative and streamlined processes to accommodate the volunteer sector. Our process is not only FCRA compliant, but currently compliant with all existing legislation in all 50 states. This proprietary system is used by organizations across the country processing background checks on hundreds of thousands of volunteers annually.
The background screening landscape changes frequently due to on-going adjustments in legislation from both state and federal governments. VICTIG takes seriously our responsibility to be informed about all legal consequences and best practices regarding volunteer screening. For this reason, VICTIG has memberships and partnerships with many professional organizations to help in current information and advocacy. Some unique memberships include NCRA (National Credit Reporting Association), Concerned CRA's, CRAHelpDesk, and TazWorks.
Test us for Free!
If you're happy, keep using us month to month.
Your information will be kept secure and confidential.
Our Volunteer Screen system is designed to accept payment types directly from the volunteer. Payment methods include ATM Debt Cards, Visa, MasterCard, American Express, and Discover Card. Consumers or Volunteers will receive a receipt regarding the transaction and the system is available 24 hours a day, 7 days a week.
Our Guarantee:
- Superior Quality
- Better Customer Service
- Quicker Turn Around Time
- Decreased Cost


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Improper Etiquette
About This Show
Leah McSweeney, creator and CEO of Married to The Mob and Laura Stylez, radio personality from Hot 97's Ebro and the Morning are launching their very own podcast Improper Etiquette. We will discuss love, sex, relationships and interview the strongest female figures in music, fashion and business. Join Leah and Laura as they allow you into their lives and bring you along for the ride. Contact us at email@example.com more »


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- Facilities
- Services
- Electronic Materials (Databases, articles, ebooks)
- Adaptive Technologies
The University of Nevada, Las Vegas Libraries is committed to providing equal access to information for all faculty, staff, students and members of the Las Vegas community. In compliance with Nevada State law, the American with Disabilities Act (ADA) and in collaboration with university policies and the UNLV Disability Resource Center (DRC), library faculty and staff will make good faith efforts to accommodate reasonable requests for assistance in obtaining, accessing, and making use of library resources, materials and services.
Facilities (features available vary by building/location)
- Accessible tables, carrels, and computers available
- Automatic doors and wheelchair ramps for users with impaired mobility
- Elevator access to all levels
- Wheelchair accessible restrooms
- Lied Library: Designated parking for users with handicap parking placards or permits in Lots I, K and N as well as metered parking available adjacent to the building
- Architecture Library: Designated parking for users with handicap parking placards or permits in Lots F and H
- Teacher Development & Resource Library: Designated parking for users with handicap parking placards or permits in Lot J
- Music Library: Designated parking for users with handicap parking placards or permits in Lots B and C
Electronic Materials (Databases, articles, ebooks)
(This section is under construction. More information to come).
The majority of the library databases come from three companies, EBSCO, Gale and ProQuest. These database vendors are compliant with Section 508 of the Rehabilitation Act and/or W3C WAI WCAG 2.0. They also provide information about their accessible features.
- EBSCO: All HTML Full Text articles in EBSCOhost databases have a text-to-speech option and an option to download the audio file as an MP3. However, many articles are not available in HTML. EBSCO PDFs after 2004 are ADA compliant.
- Gale: Provide a Listen function for full-text articles. Wherever the Listen icon is present, there is the option to have the document read aloud. The Listen tool also allows you to download the audio file as a MP3
- ProQuest: Many ProQuest documents are ADA compliant. However, older PDFs (identified as 'Scanned image PDFs') are not accessible to screen readers
UNLV Libraries offer selected services and support for patrons with disabilities. Given the availability of staff and resources at the time, this may also include assistance using the resources or equipment most appropriate to the users' expressed need.
If you have special needs, please contact the library in advance for accommodation. Questions also may be directed to Jennifer Church-Duran, Head of User Services at 702-895-2227 or email@example.com
Students who routinely need additional help using the library should contact the Disability Resources Center (DRC) prior to visiting the library to arrange for the assistance necessary to make the most effective use of library resources. DRC is located in the Student Services Center (SSC) -Room 137 (702) 895-0866, TDD (702) 895-0652, Fax (702) 895-0651.
Retrieval of Library Materials from Shelf:
- Upon request, library staff in each location can help to retrieve materials for users who need assistance. Users can ask at the service desk of the library housing the needed material.
- If the library is busy and/or there is only one staff member available at the service desk, the patron may be asked to come back later to pick up the material
- Patrons can initiate requests ahead of time via the library catalog and be notified when items are ready for pickup
- When possible, library staff will make every effort to immediately retrieve the items. Advance notice may be required for larger number of items.
- The library is best able to respond quickly to such requests during weekdays (8 am - 5 pm) rather than during evening or weekend hours.
Proxy Cards:
Current UNLV students, faculty and staff members registered with the campus Disability Resource Center (DRC) are eligible for a "proxy card." This card authorizes a designated third party to borrow books on behalf of the patron with disabilities. Please contact the Lied Library Circulation Desk for additional information.
Scanning and delivery service for local print materials:
- UNLV Libraries provides digitized copies of journal articles and book chapters from the UNLV Libraries' collection to faculty, staff, and students for their teaching and research (document delivery).
- Please make sure the items are held by the UNLV Libraries by checking the catalog. Requests can be initiated from the catalog or directly through the Interlibrary Loan online request system known as Illiad - https://unlv.illiad.oclc.org/illiad/logon.html Please include as much information as possible. Any questions about this service should be directed to Interlibrary Loan at (702) 895-2152.
Reference and Research Consultations
Reference support offered includes assistance by telephone, chat, text, email, at the desk and reference by appointment for one-on-one research consultation.
Adaptive Technologies:
Use of the Assistive Technology Computers
The University Libraries endeavor to provide assistance and instruction, which lead users to independent research, regardless of their ability. The Assistive Technology Computers are enhanced computers, located behind the Research & Information/Computer Help Desk designed to provide specialized software and hardware resources to patrons with disabilities. Because of the specialized nature of this equipment, these workstations are not intended for gaming, chat room use, reading personal emails, or other non-research related personal activities. Users engaging in such activities will be asked to relinquish the workstation for those needing to conduct educational or research related work.
UNLV students, faculty, and staff who need assistive technology to complete their learning, teaching and work have priority. Students with disabilities who require extensive assistance should contact the Disability Resource Center, located in the Student Services Complex, Room 137 at 702-895-0866 (voice) and 702-895-0652 (TDD). It may be necessary to schedule appointments for services provided by this office.
Although every effort will be made to assist users with reasonable requests to obtain needed information, staff limitations make extensive individual assistance impossible. Any assistance requiring more than 10 minutes of a staff member's time (in any department) will require an appointment.
The software listed below is available on the 2 Assistive Technologies Computers on the first floor behind the Research and Information and Computer Help Desks.
JAWS (Job Access with Speech) use an integrated voice synthesizer and the computer's sound card to output the content of the computer screen to speakers. JAWS also outputs to refreshable Braille displays. This software package is now available on workstations throughout the library. JAWS supports popular applications such as e-mail programs, word processors, spreadsheets, web browsers, project management and research tools, contract management software, presentation software, web development tools, software development tools, database management software, sound editing software, and much more.
WYNN Wizard 5.10:
WYNN was designed with the guidance of students and adults with Specific Learning Disability and special educators. Used with a standard PC, WYNN lets the user open a file and hear it read aloud, or scan in a page using a flatbed scanner and read that aloud. Once a page is opened, it can be edited by adding text or making corrections. The page can be altered for screen presentation as well as the way it is read aloud to users. To help with studying, users can insert notes and bookmarks, highlight sections, or look up words in the dictionary.
Open Book 9.0:
Open Book is software developed for blind and visually impaired individuals to read, edit, and manage scanned images from books, magazines, manuals, bills, newspapers, and other printed documents. It essentially turns a computer system into a scanning and reading machine. Additionally, OPEN Book comes complete with a wide range of productivity tools such as email capabilities, a word processing system, one-of-a-kind page layout descriptions, and a whole menu of features for low vision users.
Dragon Naturally Speaking:
Dragon Dictate, not only enables the user to dictate into virtually any Windows-based program, but also to control Microsoft Office applications. Dragon Dictate lets you control Microsoft Office applications, including Excel, PowerPoint, Word, and more, all by voice. Comes with built-in vocabularies and TalkingTools. Headsets are available for checkout from the Circulation Desk.
Kurzweil 3000:
Kurzweil 3000 is an assistive technology which provides a reading, writing and study platform aimed at people with learning disabilities or other disabilities that make reading or writing difficult. Kurzweil 3000 is used to support those with Dyslexia, Dysgraphia, English Language Learners in school, higher education, at home and in the workplace. Kurzweil 3000 can read aloud web-based, digital or scanned print material, convert web-based, digital or scanned print materials into mp3 to provide audible files to listen to on the go or through its firefly web app can be read on an iPad.
ABBYY Fine Reader 9.0 Express Edition:
OCR software helps individuals turn scans of paper documents, PDF files, and digital photographs into searchable and editable formats. Unmatched text recognition accuracy and conversion capabilities virtually eliminate retyping and reformatting. Intuitive use and one-click automated tasks let you do more with this OCR software in fewer steps. Up to 190 languages supported for text recognition - absolute record on OCR/PDF market!
FS Reader:
Daisy player software opens a world of accessible reading material for people who are blind or visually impaired.
IntelliKeys Keyboard:
The IntelliKeys Keyboard is a touch sensitive button-less keyboard. It has different overlays that provide several different interfaces for the user such as standard computer keyboard and calculator. Available for checkout from the Circulation Desk
Additional Equipment & Resources
- Topaz digital video text enlarger: located in the on the 1st floor in a carrel near the Assistive Technologies Computers (replaces Video Eye Enlarger).
- Pocket Talker (amplifies speech): located at the Research & Information Desk. Also available in the Architecture Studies Library, the Teacher Development & Resource Library, and the Music Library.
- Closed-captioning on videos can be viewed in Media Resources.
- "Grabber" to get books from high or low shelves is located at the Circulation Desk.
- Wheelchair for emergency use: located at the Circulation Desk.
- High-speed duplicator for textbooks on tape (from Recordings for the Blind & Dyslexic) is available in Media Lab.
- Copying: assistance provide for people with disabilities who are unable to use the Libraries' photocopiers (see also "scanning and delivery of local print materials")
- Dial-up access to the library catalog enables patrons with disabilities to use the library catalog without making a trip to the Libraries.
TDD (text telephone): used to respond to reference inquiries from people with hearing impairments.
- Main Library (895-2100)
- Architecture Library (895-6170)
- Teacher Development & Resource Library (895-6171)
- Areas of refuge: fire-resistant areas for those who cannot exit the building via the stairs in an emergency and have sensors to indicate to the fire department which areas have people in them.


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KING OF PRUSSIA, Pa. - January 5, 2012 --Police say a replica hand grenade that caused a partial evacuation at the King of Prussia Mall on Wednesday may have been stolen from a mall store.
In a news release issued Thursday, Upper Merion Township Police say they determined a store within The Court at King of Prussia sells replica hand grenades similar to the one found.
They believe the replica that caused the scare was stolen earlier in the day and was discarded near the Eddie Bauer Store.
When the device was initially found on Wednesday afternoon, it was unknown whether it posed a danger.
So, police evacuated about one quarter of The Court while they investigated.
The device was determined to be a fake short time later and shoppers were allowed back inside.
Police say the search continues to find the person responsible for leaving the replica grenade behind.


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TVUSD Communications Email List Serve Sign Up - Now Available
The Public Information Office sends regular communication to the email list serve to share information about the schools and District. The list serve is a great opportunity for members of the Temecula Valley Unified School District community who do not have children in the Temecula Valley schools to receive information. Parents of TVUSD students receive information regularly through through Infinite Campus. However, parents are encouraged to sign up for the list serve as an additional resource. We will also use the list serve to communicate regarding specific issues that we are currently surveying the schools and community about.
The sign up is a simple one step process and you can remove yourself from the list at any time. The email list is only used to communicate District information from the Public Information Office and is not shared with other services. We look forward to you joining us.


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Four seconds are damn fixed. You take to have accelerated BMW X 6 M and Mercedes-AMG GLE 63 S from standstill to 100 km/h. That you must seem to believe it really, try maybe one or the other comparison. Is this: move to the goal in the World Cup final game lasted from Toni Kroos' pass over Schürrles Flanken running up to the shot at goal by Mario Götze 2014 twice as long: eight seconds. In these eight seconds X 6 M and GLE would quickly 63 S about 150 km/h, bludgeoned by a power forward, but thick and tired of rolling eight-cylinder turbo.
0 to 200 km/h in 15 Seconds
So far, so good, you trust that the readily, although faced with a not inconsiderable dormant mass Yes the torque force of their engines. Is each around the 2.3 tons, and since we have to be not petty because of the scarce Zester weight disadvantage of Mercedes: they weigh almost equally much. Oh, yes, we should not ask here better sense, that would be something for philosophy seminars or Monty Python movies. To hold remains in any case, that both models in the past sold well, there obviously is a need strong all cyclists with SUV traces after almost 600 HP.
Admittedly the least customers from Europe come, X6 / X5-M predecessor of series E71's were not more than ten per cent, the ML's likely looked similar to 63 AMG. The 15 seconds the two cyclists of all need, by the way, to 200 km/h to be quick, very nice proof that the physics knowledge is still valid: grow resistances in the square of the speed. It all feels remarkably unspectacular from the driver's seat, much to do there anyway: both it is enough to depress the gas pedal. From the perspective of Franz Meersdonk the handling course seems smaller and winkliger, the view would be from the driver's seat into the Rhine Valley, if not tougher fog over the A5 depended. With frightening acceleration both eat the short straight before the double lane change, then the anchor is thrown short.
Mercedes-AMG GLE 63 S Thwarted by Electronics
Since the first differences already, those are indeed negligible in acceleration, half a second takes off the BMW X 6 M the Mercedes-AMG GLE 63 S to 200 km/h. The BMW feels more stable on maximum delay, staggers less and also required the shorter braking distances. However, the test car runs here on optional 21-inch mixed tires (2,350 Euros), the AMG has the standard 295/35-21-rubber on it. The brakes from 100 km/h are both within the measurement tolerance. But when the delay from 200 km/h, after all, a situation which is entirely conceivable at high motorway speeds, required the X.
6 M Seven-Meter Less Up to The Stop
That doesn't sound like much, but the residual speed scams turn after all, around 40 km / h. in this theoretical case, works well, back on the gas, that goes better with the X6, it under steers hardly, however tends to be irritating pounding movements on the rear axle. Nevertheless, turns the BMW with weighty grace to the pylons. In such driving conditions, the driver in the GLE comes not so easily because the Assistant electronics very early and very noticeably a slows him. You very reliably prevents that the friction of the wheels in sliding friction is over, this is a shame, because the Mercedes might be quite more. So, its active-curve system with its active stabilizers prevents too pronounced rolling movements of the massive body. How well this works, shows about the comparison on the 36-meter slalom, there he is faster a touch 63 S. through as brother AMG CLS Still somewhat outrigger BMW sweeps by the way X 6 M, which is overall somewhat neutral and less to the under steer tends as the Mercedes-AMG GLE 63 S.