text:
Why I Will Never, Ever, EVER Get a Tattoo
Would I have to start planning outfits around the tattoo like I plan for weather?
This year, like the last, the year before that, and the years before that, I dragged my four-course Christmas dinner from one side of the country to the other.
As I'm the only member of my family who is vegan, my relatives struggle to find foods that I eat, so that system where every family unit brings one course to the meal doesn't apply to me.
It's no big deal – it's hard to cook for 20 or more people, and cooking for 20 or more people plus one person who eats differently to everyone else, is even harder. In my book, fussy eaters, who don't offer help in cooking or bring some of their own food for such occasions, are assholes.
Still, I'd rather not cook all the food for all my friends and family all the time, so I'm always happy when someone offers to cater to my needs, and I guess the same holds for other vegans/vegetarians/people with allergies/fussy eaters.
So, here are my tips on cooking for (vegan) friends, plus some recipes. If you're not going to be cooking for a vegan any time soon, then feel free to use them for yourself (and your January vegan food challenges if you're Alisande) as well.
First of all, check exactly what your friend doesn't eat. 'Vegan' sounds very black and white, but it actually is a bit of grey area. No meat, no fish, no gelatin, no cochenille (a red colouring), no dairy, no eggs is pretty standard. Most vegans also don't eat honey (I do, but I'm not really a vegan, I'm a vegetarian who is allergic to dairy and eggs, so I don't mind a bit of honey occasionally).
This is just the easy stuff. Some wines, beers and fruit juices have been filtered with an animal protein-based filter, some vegans drink them, and some don't. Commercial bread often contains a product made out of pig hair to prevent it from going stale within hours. Again, some vegans don't mind, some do.
In any pre-made food product, you could find some animal part, some obvious, some not, some unintentional, some not. Everybody decides for himself or herself how far they want to go in avoiding animal products, and some people are less strict when eating out than when they are eating at home, so ask your guest about that.
This also gives you the opportunity to ask about ok brands for things like stock cubes and puff pastry. When your friend isn't vegan, but vegetarian, make sure to check whether they eat cheese made with animal rennet or not (I think this is less of an issue in the UK than in the Netherlands, as traditional Dutch cheeses have to be made with animal rennet, not a bacterial one).
And obviously, when your friend has allergies, make sure you know what they are.
Next, find out what sort of thing your friend normally eats. Most people cook for themselves quite regularly, so they know what they like, and what works in their diet. You don't have to cook them the same meal they eat every day, but knowing what they do eat makes it easier to think of new ideas.
For vegans and vegetarians, it's often as simple as switching cuisines. Western European food tends to focus on meat, with side dishes including vegetables and starch. Southern European food includes more complete meals, which are easier when you're leaving out or replacing ingredients. Asian food often already is vegetarian/vegan, so it takes minimal effort to ensure your food is appropriate for your friend.
Then, decide what you're going to make. When serving friends, I tend to cook differently to when I come home from work (then, I either nuke something I made before, or I stir fry some veggies and add tofu and nuked rice – btw, leftover rice, with a cup of water in the microwave makes the best rice ever).
Most of the time, I prefer to have something in the oven, and spend the time talking with them and having fun. But sometimes, eating is a fun activity, such as when I make vegan cheese fondue, or when we're BBQing.
After you've decided what you're going to cook, it could be wise to run the ingredients past your friend, just to be sure. Especially if your friend is like me, there are so many things I can't eat, I sometimes forget what they all are.
So, onto the recipes, I'm not a very exact cook, so neither are my recipes/tips:
MayonnaiseLets start with mayonnaise. I love mayonnaise, and use it on a lot of things, but regular mayonnaise contains egg, and store bought vegan mayonnaise usually is really expensive, and contains apple cider vinegar, which I cannot have because of my apple allergy. So, instead, I make my own mayonnaise, and it is really simple:
You'll need 2 parts soy milk, 3 parts neutral oil (I usually do 100 or 150 ml, but ½ cup and ¾ would work just as well, or tablespoons if you really need a little), some mustard, some vinegar, salt and pepper.
Make sure all the ingredients are room temperature, blend the soy milk and oil, and season your mayonnaise with the other ingredients. It will be really pale, and sometimes mine comes out runnier than other times - I have no idea why this is.
This is a pretty good basis for other things; add garlic for vegan garlic sauce; replace some of the neutral oil with truffle oil for truffle mayonnaise; add horseradish for a dressing for your beet Carpaccio; add gherkins, onions and some of the fluid the gherkins come in for a dressing for your oven potatoes; or add cumin, agave syrup and cilantro for a dip.
Leek piePies are pretty perfect friend food for me. You put it in the oven before your friends arrive, have a nice chat, toss up some salad, and take your pie out of the oven. Leeks are available all year around and are pretty cheap, and this pie freezes really well, so if you have any leftovers you don't need to eat the same pie all week.
You'll need leeks, 750 grams to a kilo/26-56 ounces for a regular size, some margarine, vegan pastry, some flour, sundried tomatoes, almonds, no-egg and soy cream.
Heat up some margarine, and braise the chopped leek until tender. In the meantime, preheat the oven to 180 degrees Celsius/350-360 Fahrenheit, butter your tin and blind bake your pastry (I either use vegan puff pastry or the vegan pie pastry, whatever I have in the fridge).
Once the leeks are soft, you need to check how moist they are – drain any excess liquid, add the flour and stir. Add the chopped up sundried tomatoes (I like sundried tomatoes, so I use about half a jar), and add the almonds. I prefer the sliced ones for baking (which I roast a little), but regular chopped up almonds work as well. I use about 50-100 grams/2-3,5 ounces, but you can do what you prefer.
Now mix the no-egg with water, and then add the soy cream, and add that to the leeks. (I thought corn starch would be a good alternative if you didn't want to buy no-egg, so I tried that out for you, I think it does have a slightly less neutral taste, but I'm not sure, as I forgot to mark the pie with cornstarch, so I couldn't tell which one it was).
Alternatively, if you're not cooking for vegans, you could use a couple of eggs, and replace some of the almonds with goat's cheese. Pour the entire mixture in your pastry-lined tin and put in the oven for 45 minutes to one hour.
You can serve this in summer with a salad of tomatoes, roasted almond slices, basil and balsamico, but in the winter it also tasted great with a salad with lettuce and some oven roasted veggies. When I have leftover couscous salad, I serve that with it.
Vegan cheese fondueThis also is a great friend food. You cannot do much of the preparation before hand, but it does give you a terrific excuse to spend the night at the table, dipping things in chäs.
You'll need about one sausage roll of vegan cheese (chäs) "no-muh Melty" per person, 2-3 glasses of wine per sausage roll and garlic.
Heat up the wine with the garlic, add the chäs, and add more wine until the consistency is okay. I serve this with broccoli and Brussels sprouts that have been microwaved, cherry tomatoes, raw bell pepper, grapes, small potatoes (also the microwave kind), garlic mushrooms and bread.
I sometimes do a salad on the side, but this is a really fulfilling meal without it already.
What are your top tips for cooking for vegan/vegetarian friends? Share with me!


text:
Corporate Clients
This service is only for corporate and business houses. Step by step advice for new companies as well as existing companies.
- Company Name.
- Company Logo (Color & Other Themes)
- Positive & Negative time cycles for the Company.
- Several other factors involved to create:
- Positive energy in the company,
- Positive growth,
- Support by investors and financial institutions.
- Creating better environment for employees
- Liking by customer and clients
Note: Before you subscribe to this service please contact Mr. Mahendra Sharma via email or phone, as he takes limited personal clients. Once he approves to take you as a personal client then you can subscribe to this services.
Please read our disclaimer before you order our services https://www.mahendraprophecy.com/disclaimer.php
Updates & News
Read Website updates & news by Mahendra Sharma
View Details
Consultation Services
consultations from Mahendra Sharma.
View Details
Daily Flash News
Receive daily trading range and strategies before the market opens. View Details
Lithium, Cobalt, Gold & Natural resources
Receive outlook of Lithium, Cobalt, Gold & Natural resources in this monthly newsletter. View Details
Personal Clients
This service is only for high net-worth and corporate clients.
View Details
Remarks from Known Personalities
"As a journalist, I have interviewed and written on Mahendra's predictions. What has always amazed me is the degree of accuracy of his predictions. Mahendra remains one of the greatest astrologers of our times."
Ongango Omolo, Journalist - (Editor - Kenya Times)

subset: commoncrawl


text:
Put your boners away kids, it appears that Hollywood attention whore Lindsay Lohan has joined the other team boys. Fresh from Eonline.com:
"After months of hints, Lindsay Lohan has finally confirmed the worst-kept secret of the year: she and constant companion Samantha Ronson are, in fact, a couple.
Lohan and Ronson have been living together since May, but have played coy about the nature of their relationship. Lohan jokingly referred to Ronson as her "girlfriend" back in July during one of Ronson's DJ gigs, saying, "My girlfriend won't play my songs."
Wow, looks like gods finally decided to save us fellas. Lock up yer daughters, there's a Lohan on the loose. And in this humble blogger's opinion, she can do better.


text:
The Muppets Take Selfies
Everybody loves to take selfies these days, so they keep their smartphone in hand wherever they go so they don't miss an opportunity.
The Muppets are no different, they love a good selfie and since their new movie Muppets Most Wanted is coming out soon it's the perfect time to get their fleece covered faces out there again via Instagram.
Rizzo's smartphone must be as big, or bigger, than his whole body- how does he carry that thing around with him?
-Via Nerd Approved
Newest 1 Comment
Is the Swedish Chef giving a duck face?
Abusive comment hidden. (Show it anyway.)
We hope you like this article!
Please help us grow by sharing:
Get Updates In Your Inbox
Free weekly emails, plus get access
to subscriber-only prizes.
We won't share your email. You can cancel at any time.


text:
Straight Talk Clear Decisions
About This Show
Our show, Straight Talk Clear Decisions, is an outlet for the Rik Saylor no-nonsense approach to demystifying the world of investments and wealth management. We help people grow, use and keep their wealth in a simple, straightforward fashion. By utilizing Transparent Wealth Management, we believe you, as an investor, should know what you're buying, what the true total costs are, and what it is going to do for you. Our holistic approach is an end to end process. We offer either fee or commission based wealth advisory services. Our tax efficiency, planning and preparation help you keep more of your hard earned wealth. Know you have the right coverages at a fair price for your insurance protections. With probate avoidance estate planning and elder law, pass your wealth along to your loved ones rather than to courts, attorneys, and hospitals.Read more »


text:
Navigating the Remote Control
Most audio and video devices, such as televisions, DVRs, stereo equipment and DVD players, include a remote control. Some remotes are basic and easy to use, but more often than not they have buttons that you will never even use, let alone learn what they do. Of course, there are universal remote controls as well, which promise to simplify your life by controlling multiple devices.
Whether you are shopping for a new remote, looking for programming assistance or need other information, this guide is here to help with detailed tutorials, troubleshooting steps and product reviews to help you make an informed decision.
Image credit: sxc.hu/Ernesto Ferreyra
Gadgets You Have to Try This Winter!
Don't let winter weather get the best of you! Take a look at our picks for the top 10 gadgets designed to keep you warm, active and having fun - no matter what the temperature!...
Unbelievably Awesome Gadgets For Kids
Coolness is in the eye of the beholder, yet most people will agree that all of the gadgets in this list are pretty cool! This list is divided into two age groups determined by difficulty...
Vroom Vroom! RC Cars Buying Guide
Buying someone an RC car in the holidays can be pretty stressful; which is a shame as the cars themselves are so much fun! Whether you are buying for a toddler, a teen, or that...
The Best Toys and Games for the Whole Family
There are a wide number of different types of electronic toys and games available on the market today. This guide will provide you with reviews, suggestions and advice on what to look...
Careers in Technical Writing
If you are thinking about pursing a technical writing career, here we'll cover all you need to know about this exciting field. We will look at the basic skills needed and look at...
Where and Why to Recycle Remote Controls
Got a broken or outdated remote control? You're in the right place! We'll tell you how and why to recycle remote controls. Keep that old remote control out of a landfill...


text:
NJ is a jurisdiction where the employer has exclusive control over the selection of medical providers for workers' compensation claims. NJ also has no medical fee schedule. Neverthe less, WCRI report that medical costs per claim are increasing above the national average.
The report, CompScope™ Medical Benchmarks for New Jersey, 15th Edition, found medical payments per claim grew less than 3 percent per year from 2010 to 2012―about half the annual rate of the prior three years.
The study cited changes in both key components of medical payments per workers' compensation claim: the price paid for each service rendered and the number of services performed in each claim (generally called utilization).
The study found a decrease or little change in utilization of many nonhospital services─a key factor in the recent slower growth in medical costs because payments for nonhospital care accounted for roughly two-thirds of medical payments in New Jersey. Slower growth in hospital outpatient payments per service was also a factor. Payments for hospital inpatient treatment continued to rise though.
The recent trends coincided with an increase in the use of networks in caring for injured workers. States that do not regulate reimbursements for medical care through a traditional fee schedule (like New Jersey) often use medical networks to help control medical costs through the management of claims and negotiated payment discounts.
Despite the recent slower growth, medical payments per claim in New Jersey remained higher than most of the 16 states WCRI studied, primarily due to higher prices paid for medical care.
In several states, WCRI researchers saw slowdowns in claims growth similar to what they found in New Jersey, namely growth of 3 percent or less from 2010 to 2012, after growth of 4 to 8 percent a year, on average, from 2007 to 2010. Reasons for the slowdown differed by state, the study said.
The Cambridge-based WCRI is recognized as a leader in providing high-quality, objective information about public policy issues involving workers' compensation systems.
Click on the following link to purchase a copy of this study:http://www.wcrinet.org/result/csmed15_NJ_result.html


text:
Publication date: 06.07.2012
GATTW, June 2012, 172 pages The Anti-Trafficking Review promotes a human rights based approach to human trafficking. It explores trafficking in its broader context including gender analyses and intersections with labour and migrant rights. The Review's fo ...Read More
Publication date: 10.10.2012
human_trafficking_in_spain_invisible_victims_conclusions_en.pdf human_trafficking_in_spain_invisible_victims_es.pdf ... human_trafficking_in_spain_invisible_victims_en.pdf human_trafficking_in_spain_invisible_victims_summary_en ...Read More
Publication date: 29.10.2012
Secretary of State for the Home Department, October 2012, 107 pages This report sets out an assessment of human trafficking in the UK by the Inter-Departmental Ministerial Group on Human Trafficking (IDMG). It notes that the UK has already achieved signif ...Read More
Publication date: 16.11.2012
"The Way Forward in Establishing Effective Transnational Referral Mechanisms. A Report Based on Experiences in Cases of Human Trafficking in South-Eastern Europe". International Centre for Migration Policy Development (ICMPD), 2012, 162 pages The report c ...Read More
Publication date: 13.04.2012
IOM, February 2012, 32 pages IOM 2011 Case Data contains information on all trafficking cases assisted by the organisation in 2011. The tables contained within this document are based upon IOM case data where the organisation has been involved in providin ...Read More
Publication date: 20.10.2011
October 2011, European Parliament, 139 pages This study, commissioned by the Committee on Women's Rights and Gender Equality of the European Parliament, focuses on the case of young women employed as domestic workers under the cover of the statute of ...Read More
Publication date: 24.05.2012
International Labour Organization 2012, 148 pages This Implementation Report provides a summary of the work of the ILO's International Programme on the Elimination of Child Labour during 2010-2011. The report also provides an overview of significant ...Read More
Publication date: 12.06.2012
International Labour Organization 2012, 134 pages Domestic workers are often excluded from the protection of labour laws or are treated less favourably than other wage workers. National labour laws should be better assessed and strengthened implementing ...Read More
Publication date: 12.06.2012
Anti-Slavery International June 2012, 60 pages This report identifies two forms of modern day slavery in fabric and garment supply chains: the forced labour of girls and young women in the spinning mills of southern India – the Sumangali and Camp Coolie s ...Read More
Publication date: 19.06.2012
U.S State Department, 2012, 61 pages Like previous editions, the 2012 Trafficking in Persons Report looks closely at how governments around the world are fulfilling their obligations to combat trafficking in human beings. The report makes government-speci ...Read More


text:
Printable PDF
Vendor: Citrix
Certifications: CCA
Exam Name: Citrix XenServer 6.0 Administration
Exam Code: 1Y0-A26
Total Questions: 125 Q&As
Last Updated: Aug 13, 2018
Note: Product instant download. Please sign in and click My account to download your product.
dump is valid.
Passed today with 938. There are a lot of D&D but only 3-4 new. Thank you all!
Valid. Passed Today.....So happy, I will recommend it to my friends.
I passed the exam today with 9xx. Dump is valid.Thank you all and special thanks to my friend Neil.
update quickly and be rich in content, great dump.
I studied this material carefully and took every question seriously. At last, I passed the exam with high score. Prepare well and study much more.
Hello, guys. i have passed the exam successfully in the morning,thanks you very much.
I really felt surprised that i would pass the exam with so high score by using this dump. I will share this good study material with my friends.
very good study material.
All the questions I had on exam were in this dump. I just passed my exam yesterday. Full scored. Thanks very much for your help.
At Lead4sure, we provide thoroughly reviewed Citrix CCA 1Y0-A26 training resources which are the best for clearing 1Y0-A26 test, and to get certified by Citrix CCA. It is a best choice to accelerate your career as a professional in the Information Technology industry. We are proud of our reputation of helping people clear the 1Y0-A26 test in their very first attempts. Our success rates in the past two years have been absolutely impressive, thanks to our happy customers who are now able to propel their careers in the fast lane. Lead4sure is the number one choice among IT professionals, especially the ones who are looking to climb up the hierarchy levels faster in their respective organizations. Citrix CCA is the industry leader in information technology, and getting certified by them is a guaranteed way to succeed with IT careers. We help you do exactly that with our high quality Citrix CCA 1Y0-A26 training materials.
Citrix CCA is omnipresent all around the world, and the business and software solutions provided by them are being embraced by almost all the companies. They have helped in driving thousands of companies on the sure-shot path of success. Comprehensive knowledge of Citrix CCA products is considered a very important qualification, and the professionals certified by them are highly valued in all organizations.
Experience Lead4sure exam material in PDF version.
Simply submit your e-mail address below to get started with our PDF real exam demo of your Citrix 1Y0-A26 exam.
Instant download
Latest update demo according to real exam


text:
$ 58.00
Color: Black
Material: 45% Viscose 30% Polyamide 25% Polyester
Item Fit / Dimensions: Relaxed fit
Made In: United States
Shipped From: United States
Lead Time: 1 - 2 days
$ 80.00
Boho style mini dress Gauzy polka dot hem Adjustable waist Fully lined Linen (cotton) Halter style Stylist suggestion: Unlike the other colors, cream is slightly sheer. We suggest wearing nude or white shorts or underwear...
$ 119.00
This piece is 100% Viscose Off the shoulder, long bell sleeve, with lace details and fringe Hand wash cold and lay flat to dry Model is wearing a size S Made In: United States Shipped...
$ 87.00
A firm compression Core Trainer zip up corset, this Latex and cotton corset work out band is comfortable yet strong. Instantly improves posture and slims the whole midsection. High-tech cotton lining provides comfort and breathability...
$ 288.00
Reproduction of George Nelson Bubble Pear Criss Cross Pendant Lamp Material: Constructed from a super lightweight wire frame, covered with a woven white polymer cocoon material and sprayed over with a protective coating Color: White Dimensions: Diameter 43.18cm x...


text:
Prom Flowers
CorsagesCan't find what you're looking for? Let us create a custom prom corsage just for you or your date. Simply call or stop by BRIARWOOD FLORIST with a photo or description and we will take care of the rest. Our beautiful prom corsages are design to make any girl feel like a princess as she dances the night away.
The flower-on-the-coat-pocket is a tradition for classy men that stems back generations. Just because it's a tradition, doesn't mean your boutonniere doesn't have to be stylish. Choose from a wide range of styles, colors and flowers when choosing a boutonniere from BRIARWOOD FLORIST.
Hairpieces & Handheld Bouquets
Looking for the perfect accessory? Let BRIARWOOD FLORIST create a custom floral headpiece or bouquet to match your personality! From classical elegance to playful and fun, we do it all!


text:
Some of the best fuel reward programs come from credit cards like Chase Freedom, Blue Cash Preferred from American Express and PenFed Platinum Rewards Visa Signature Card. In addition to offering ongoing rewards, these cards sometimes offer signup bonuses.Continue Reading
The Chase Freedom card allows users to earn 5 percent cash back on gas at various points during the year. However, this cash back reward switches to other purchases during different quarters.
The Blue Cash Preferred Card from American Express offers an unlimited 3 percent cash back on gas purchases throughout the United States.
The PenFed Platinum Reward Visa Signature Card gives people 5 points for every $1 they spend on gas. It is worth bearing in mind that these deals can change each year.Learn more about Geography


text:
Featured News - Current News - Archived News - News Categories
State University of New York Empire State College will hold public information sessions about its associate and bachelor's degree programs at its Niagara Frontier Center, Appletree Business Park, 2875 Union Road, Cheektowaga, on the following dates:
To reserve a space for an upcoming information session, visit www.esc.edu and select the location nearest to you or call 716-686-7850. You may also register by calling 800-847-3000 and selecting option 1.
This information session will discuss most of the undergraduate programs at the college.
If you are specifically interested in the college's R.N. to Bachelor of Science degree program, call 1-877-372-6790 to receive information about the nursing program.
State University of New York Empire State College serves more than 20,200 students worldwide at 36 locations in New York state and online. Its 63,000 alumni are active in their communities as entrepreneurs, politicians, business professionals, artists, not-for-profit agency employees, teachers, veterans and active military, union members and more.
For additional information, visit www.esc.edu.


text:
Turner was sentenced to six months in jail for sexually assaulting an unconscious woman in January 2015. The sentence sparked outrage nationwide by many who felt Judge Aaron Persky was too lenient.
RELATED: Victim writes letter to Brock Turner
The victim's emotionally charged 12-page impact letter was read by countless people, including Congresswoman Jackie Speier and her colleagues on the house floor.
Rosen said it started a revolution. "We're hoping to change hearts, change minds and change the law by protecting the next Emily Doe against the next Brock Turner," he said.
RELATED: Campaign launched against judge in Stanford sexual assault case
Turner, the former Stanford swimmer, was convicted of sexual assault on a victim who was unconscious from drinking too much at a party.
Conviction for sexual assault on a conscience person carries a mandatory prison sentence and that's not the case when the victim is unconscious.
Rosen said he will now support a proposed bill that would change that. "In this case, we would then have the same consequences for sexual assault of an unconscious person, meaning mandatory prison," he said.
Others want Persky removed from the bench. A group called Ultraviolet sent one million signatures to the state commission on judicial performance.
Still others are going to the ballot to recall the judge. "I don't think the answer is to change the law. The answer is to change this judge," Stanford law professor Michele Dauber said.
The petition signed by Santa Clara County public defenders supports the judge saying, removing him for a controversial sentence destroys judicial independence.
Deputy public defender Gary Goodman does not support the bill Rosen is pushing. "The statutes that are already in place for these types of crimes have been vetted in a slow and careful manner, this is not," Goodman said.
There will be hearings on the bill AB2888 next week in Sacramento. The assembly and senate would have to pass it and then it would go to the governor's desk to be signed into law.
ABC7 News' Matt Keller contributed to this story.
Click here for full coverage on the Brock Turner case.
SCDA Rosen supporting bill banning probation for sexual assault of victims who are unconscious/intoxicated. pic.twitter.com/iq9IPyoGqz— Vic Lee (@vicleeabc7) June 22, 2016
DA Jeff Rosen- "Judge gave the wrong sentence but had the right to give it."#BrockTurner case pic.twitter.com/HeirbmMhJM— Matt Keller (@MattKellerABC7) June 22, 2016
SCC DA Jeff Rosen-legislation would make sexual assault of intoxicated/unconscious person "probation ineligible" & serve sentence in prison.— Matt Keller (@MattKellerABC7) June 22, 2016
SCDA Rosen supporting bill banning probation for sexual assault of victims who are unconscious/intoxicated. pic.twitter.com/iq9IPyoGqz— Vic Lee (@vicleeabc7) June 22, 2016
SCC DA Jeff Rosen on tougher legislation & legacy for #BrockTurner victim. pic.twitter.com/ooEpvfeLdP— Matt Keller (@MattKellerABC7) June 22, 2016
SCC DA Jeff Rosen holding 10am press conference to discuss legislation inspired by victim in #BrockTurner case. pic.twitter.com/lFN8Ua4POF— Matt Keller (@MattKellerABC7) June 22, 2016
Petition to remove Judge Aaron Persky after sentencing in #BrockTurner case has 1,263,756 supporters.https://t.co/Sd9BdEV2wP— Matt Keller (@MattKellerABC7) June 22, 2016
Petition started in support of Judge Aaron Persky & Judicial Discretion related to #BrockTurner sentencing. https://t.co/6cryqDZE2g— Matt Keller (@MattKellerABC7) June 22, 2016


text:
January 07, 2013 16:52 ET
TORONTO, ONTARIO--(Marketwire - Jan. 7, 2013) - Front Street Flow-Through 2011-I Limited Partnership and Front Street Flow-Through 2011-II Limited Partnership (the "Partnerships") announced that they will be proceeding with the direct and indirect tax-deferred transfer of the assets of the Partnerships (the "Mutual Fund Rollover Transaction") into the Front Street Resource Class ("Front Street Resource Class"), a fund class of Front Street Mutual Funds Limited. The transaction will take place on or about January 31, 2013 after the close of business. In exchange for the assets, Series B Shares of Front Street Resource Class will be issued to the Partnerships and then distributed to individual limited partners. The Partnerships will be dissolved on or about February 8, 2013.
Redemption Option: Series B Shares of Front Street Resource Class are in book-entry only form. Consequently, limited partners of the Partnerships who want to redeem their Series B Shares must contact their brokers or dealers to exercise the redemption option. When shares are redeemed, Front Street Resource Class will send the shareholder the proceeds within three business days after the calculation date for the net asset value used in establishing the redemption price. The Series B Shares issued under the Mutual Fund Rollover Transaction may be redeemed through FundServ after the rollover, once the individual holders' investment advisor has reconciled the positions with FundServ.
Front Street Resource Class: Front Street Resource Class is a fund class of Front Street Mutual Funds Limited which is a mutual fund corporation incorporated under the laws of Canada, with Gary Selke as its Chief Executive Officer. Its head office is located at 33 Yonge Street, Suite 600, Toronto, Ontario. Front Street Resource Class securities are sold under a continuous offering prospectus. Front Street Resource Class is a reporting issuer for securities law purposes in all provinces and territories of Canada.
Front Street Resource Class is advised by Front Street Investment Management Inc. (the "Portfolio Advisor"), the same investment advisor that has advised the Partnerships. Front Street Resource Class's investment objective is to maximize capital appreciation by investing in small and medium-sized business entities in a range of natural resource sector industries, including base and precious metal mining and exploration and in energy-related industries. The Portfolio Advisor will assist Front Street Resource Class in selecting investments primarily in equity and equity-related securities, although Front Street Resource Class may also invest in other securities, including preferred shares, of such resource issuers, including junior resource issuers, with the objective of achieving capital appreciation for shareholders.
Front Street Resource Class will not charge a fee or commission when Series B Shares are issued under the Mutual Fund Rollover Transaction and will not charge redemption fees. Front Street Capital 2004, the Manager of Front Street Resource Class, will be entitled to an annual management fee equal to 1.5% of net asset value of the Series B Shares and will be eligible for a performance fee.
Fund Shares: Shares of Front Street Resource Class are categorized into series, being Series A Shares, Series B Shares, Series F Shares, Series L Shares and Series X Shares. Only Series B Shares are being issued under the Mutual Fund Rollover Transaction. Series B shares will be distributed on a "no load" basis. The issue price of the shares is based on the Net Asset Value per share determined in accordance with the Mutual Fund Rollover Transaction. Front Street Resource Class will not issue share certificates, but will send shareholders a confirmation statement relating to all purchases and redemptions of shares within fifteen days of a transaction.
Additional Information: The continuous offering prospectus of Front Street Resource Class is available to limited partners of the Partnerships through their broker or by calling Front Street at 1-800-513-2832. It is also available on SEDAR at www.sedar.com.
Front Street Capital 2004Investor Relations416-364-1990 or email@example.com
See all RSS Newsfeeds


text:
Los Angeles Constitutional Statutory Rights Lawyers
What Do Civil Rights Laws Protect?
Discrimination refers to treating people unequally based on their status.
Federal and state laws protect people from discrimination and guarantee fair treatment in many settings. These laws, known as civil rights laws, protect people from discrimination in:
- Employment
- Housing
- Education
- Receipt of credit
- Public accommodations
- Medical affliction
- Retaliation
There are many important pieces of federal legislation, making discrimination illegal. These discrimination laws include:
Title VII of the Civil Rights Act of 1964 (Title VII), which prohibits employment discrimination based on race, color, religion, sex, or national origin; the Equal Pay Act of 1963 (EPA), which protects men and women who perform substantially equal work in the same establishment from sex-based wage discrimination; the Age Discrimination in Employment Act of 1967 (ADEA), which protects individuals who are 40 years of age or older; Title I and Title V of the Americans with Disabilities Act of 1990, as amended (ADA), which prohibit employment discrimination against qualified individuals with disabilities in the private sector, and in state and local governments; Sections 501 and 505 of the Rehabilitation Act of 1973, which prohibit discrimination against qualified individuals with disabilities who work in the federal government;
Title II of the Genetic Information Nondiscrimination Act of 2008 (GINA), which prohibits employment discrimination based on genetic information about an applicant, employee, or former employee; and the Civil Rights Act of 1991, which, among other things, provides monetary damages in cases of intentional employment discrimination.
But there are many other additional federal statutes, as well as California laws, prohibiting discrimination.
Ageism, sexism, and other forms of discrimination can have serious legal consequences. It is wise to consult a skilled discrimination attorney to see determine whether your civil rights have been violated.
Types of Discrimination
Your discrimination law attorney can help protect you against many different kinds of constitutional and statutory violations of your rights. Discrimination can be on the basis of such things as:
- Age
- Race
- Sex
- Disability
- HIV status
- Immigration status
- National origin
- Religion
- Medical and psychological condition
Laws prohibiting discrimination are vast and complex. For example, under federal law, an employer is required to reasonably accommodate the religious belief of an employee or prospective employee, unless doing so would impose an undue hardship. Because there are so many layers to discrimination law, it is important to seek legal advice from experienced lawyers who can assess whether your civil rights have been violated.
Examples of Racial Discrimination in Employment
There are many types of discrimination in different settings. For example, in the workplace, discrimination based on race can include discriminatory acts such as:
- Hiring procedures which tend to disfavor certain races
- Assigning difficult or dangerous jobs to persons of color
- Giving a greater workload to those of certain ethnic groups
- Giving lower salaries to minority groups
- Offering fewer benefits depending upon racial identity
- Offering fewer chances of promotion depending on race
- Offering fewer opportunities for training depending upon the person's racial group
Contact an Experienced Civil Rights Attorney
At the Los Angeles constitutional statutory rights lawyers firm of Arias Sanguinetti Wang & Torrijos, we represent people whose civil rights have been violated.
If you believe you have experienced suffered a violation of your civil rights, it is important to seek legal assistance. Our attorneys are distinguished by their experience and track record of successfully representing individuals who have suffered from discrimination. Contact our law offices today for a legal consultation.


text:
Course Earns National Award from Humane Society of the U.S.
An academic course at Eastern Kentucky University has earned national recognition from an unusual source.
The Humane Society of the United States and the Animals and Society Institute have honored the university's Introduction to Animal Studies course, taught by Dr. Robert Mitchell, with its 2011 Distinguished Established Course Award.
The course is part of EKU's Animal Studies baccalaureate degree program, which became the first such undergraduate major in the world when it was established in 2010. The cross-disciplinary program, housed in the Department of Psychology, concentrates on non-human animals, their interactions and relationships with people, and the mutual influences that humans and non-human animals exert on each other's existence, evolution and history.
The winning course is a survey of the field of animal studies, focusing on animals' lives and histories, and the human experience of animals as food, as objects of entertainment, spectacle and science, as companions, and as representations.
"Among the things I want students to learn is how conflicted and confusing our ideas and treatment of animals are, how to think about animals and people in interaction in such a way as to benefit both, and ways to make animals' lives better," said Mitchell, coordinator of EKU's Animal Studies Program. "I also want students to take animals' points of view, and to understand how differently people may think about animals."
Judges from The Humane Society of the United States and the Animals and Society Institute evaluated the submissions using criteria such as depth and rigor within the topic, impact on the study of animals and society, and originality of approach. The honor includes a cash award of $1,500 to EKU's Animal Studies Program.
"The increasing presence of animal studies courses within institutions of higher education worldwide is a true marker of expanding interest in the human-animal bond," said Dr. Bernard Unti, senior policy adviser and special assistant to the CEO of The Humane Society.
In an announcement recognizing the award, the EKU course was praised as "one of the few attempts at a truly cross-disciplinary syllabus" and for a range that covers "several fields: psychology, history, philosophy, social justice and cultural studies."
The EKU course was first taught in Fall 2010 and is taught by Mitchell every fall semester. Twenty-six students, mostly animal studies majors, have taken the course each semester thus far. Forty-five EKU students are majoring in Animal Studies.
Incorporating applied fields, science and the arts and humanities, other courses in EKU's Animal Studies include Animals in History, Animal Ethics, Sociology of Animal-Human Relations, Animals in Literature, General Zoology, Comparative Psychology, Ecology, Animal Behavior, Principles of Animal Science, Primate Conservation, Animals and the Law, Wildlife Law and Law Enforcement, Principles of Biology, Introduction to Cultural Anthropology and Introduction to Physical Anthropology, among other requirements and electives.
For more information about EKU's Animal Studies Program, visit psychology.eku.edu/animal-studies-major or call 859-622-1105.
Published on January 13, 2012


text:
IVI styles for women, the Dusky and Daggerwing, are dripping in color for Spring 2013. The acetate/ lens color way, "Aqua Fade" was developed by Mage Design's team before being produced by IVI's separate manufacturing partners, Zeiss and Mazzucchelli. Learn more about IVI's design & manufacturing process, here.Comments (0)
cara with kittens
Kittens courtesy of Mirren Stewart. Cara Delevingne wears 'Vanitas' choker necklace and earrings, 'Snow White' ring, 'Emploi Du Temple' cuff, expandable necklace (worn as cuff) and wing, all by Delfina Delettrez. Sequinned trouser-suit by Meadham Kirchhoff, embroidered shoes by Prada (via)
Burton S/S 2013 Lookbook
brings on spring with a breakthrough 2013 Spring/Summer apparel and bags collection that captures the spirit of snowboarding in styles for hot days and long nights. "Designed here at Mage Design, "the new line celebrates the spirit of snowboarders in a different season, with playful clothes and transitional outerwear designed for good times in rain or shine." – Transworld SnowboardingComments (0)
Frederik Heyman Photography
Dosnoventa with Lacoste Live
Dosnoventa bike frames have put together this little inspirational video with the help of Lacoste Live. Some bikes, pedals, motors and fashion…..hipsters unite!
WE WERE NEVER BORN from CREAM Bikes & Things on Vimeo.Comments (0)
In the past 2 years, photographer Charles Fréger spanned various countries in Europe documenting these winter rituals. An inner primal act of their own human nature, men dress for different festivals and traditions causing little children to cry themselves to sleep everynight.Comments (0)
GIVENCHY rx pharmacy efeito http://cialis4saleonline-rxstore.com/ do cialis MEN'S viagra cialis once a day dose at walgreens viagra 120mg price S/S original cialis price viagra otc 2013 sildenafil
FOR cialis 20 or 40 BARNEYS NEW pet pharmacy canada YORK cialis cialis 20 mg betegtájékoztató cialis canada commercialComments (0)
blurred vision / andy denzler
Mage Design's optics-inspired creation for Skullcandy, "The Aviator" has been the mainstay of the brand's headphone collection since the height of it's launch in 2010. Most recently, the style is
showcased as the feature product in Skullcandy's "Designed By You" program for consumer customization. Now you can choose cap, cord, headband and frame coloration from a variety of existing colors in the program's color palette. Head over to their site to create your own custom headphones.Comments (0)


text:
Posts tagged character
Lost Characters7
I started watching the TV show X-Files when I was a freshman in college and I was hooked pretty immediately. About a year later when FX aired the entire series in order I video-taped (on VHS in those days) and watched the whole series. A decade later when I was almost done with college my friends Aaron and Russ wanted to watch the series, which they'd never seen before. But X-Files was a pretty long-running show, so we decided to just watch the episodes related to the alien conspiracy. Since I'd seen the series before I served as our guide. I found some lists of the alien episodes online, but I wasn't really happy with the choices that they'd made and I ended up curating my own list of the episodes that would best let us watch the over-arching plot line.
X-Files is kind of a unique show because it let us do this. There are two kinds of X-Files episodes: the episodes that are part of the over-arching plot line of the alien conspiracy, and the stand-alone episodes of some weird supernatural thing that isn't alien related. There really isn't much of a middle ground. (Star was also an X-Files veteran and would sometimes watch with us, but she was and still is opposed to our approach, and in some ways she's right: Most of the very best episodes were stand-alone episodes because they were so creative and often had really excellent writers.)
Ever since then I've thought about that idea of analyzing how required an episode is if you want to keep watching the series. I don't think most TV shows are as clear-cut as X-Files was. Even shows that do have over-arching plot lines and random single-episode plots, they usually sprinkle and mix them so that there's at least something related to the over-arching plot in every episode. You can't usually cut out whole episodes and expect to understand what's going on in the next episode.
Recently we've started re-watching the TV show Lost, and the third episode of the show suggests a different way for an episode to be really important to the series.
Really nothing happens in the episode to further the overarching plot. There are several reminders of important things going on but nothing new really happens. Sure they talk about being off-course and the weird radio signal, but they're just reminding us of what's happened in other episodes. In other words, if you completely missed this episode you could still watch the next one and understand everything that was going on.
Even though you wouldn't have missed any plot milestones, you would have missed some really important milestones for our characters. There are tons of instances in this episode where you get a first look at attributes of these characters that end up being really important during the rest of the show. So maybe the episode is still really essential for watching the whole series, but for very different reasons. You could understand the plot without this episode, but you might not understand the characters without it.
Consider these scenes and what we learn about the characters:
- When Jack goes into the airplane wreckage to rummage for medicine he finds Sawyer already in there rummaging for anything else of value. They debate the ethics of rummaging for supplies, and Sawyer suggests that Jack is acting like he's still in civilization while Sawyer sees them as being "in the wild". I think there's an interesting irony that's presented here. Sawyer is "in the wild" as far as his morals are concerned, having no problem taking from the dead nor from the rest of the castaways in order to benefit his personal stash. However, Sawyer is calm and collected as he does it. Jack on the other hand, operates for the common good and is slowly creating the civilization of the island. But here we see him rushed and almost panicked as he rummages for medicine, and he seems at the end of his wits, like he might just attack Sawyer at any second. We see this battle of values and personalities between Sawyer and Jack over and over during the course of the show, and this first encounter sets it up perfectly.
- This is really Kate's episode, and so you see multiple sides of Kate in it. One side is the dangerous criminal. The marshall tells Jack that she is dangerous and that she shouldn't be trusted.
- During the conflict over the gun, Kate gets nominated to carry it. She walks around camp with a gun and no one seems to mind except for Hurley. While we were watching this part Kelly said out loud, "It's amazing that people are OK with her just walking around with a gun." The thing we really learn about Kate through this is that she is able to command trust from her peers.
- The marshall and Kate have two encounters when he is conscious: in the first the marshall attacks her and tries to strangle her, and in the second he has a kind of fond-farewell to Kate, even to the point of asking her to put him out of his misery. Here you see the other pieces put together: Kate is dangerous and the marshall both hates her and fears her, but he also strangely sees her as a trusted friend and relies on her to be compassionate to him.
- You see this dual nature of Kate again in the attempted escape after the farmer sells her out. She is willing to do anything to get away, crashing the truck but ultimately she allows herself to be slowed down to save the farmer from the burning wreckage. She was just dangerous enough to crash the car, but too compassionate to allow the farmer to die, even when it meant her being caught.
- Sawyer tells Kate that since she has the gun she should put the marshall out of his misery. He doesn't know that Kate was the fugitive and that it actually would serve Kate's interests if the marshall weren't around anymore. We don't see the rest of the conversation, but later we see it's outcome when Sawyer has the gun and shoots the marshall. Here we see Kate as a con artist herself, conning the conman into doing something that really serves her more than anyone else, and you can imagine that she's done it in a way that Sawyer thinks that he's convinced her.
- When Sawyer leaves the tent after shooting the marshall, he has a look of pain and sorrow on his face. Jack confronts him and Sawyer justifies his actions and makes a convincing argument that he was actually being merciful to both the marshall and the rest of the passengers. But because of the looks on his face, you get the idea that he isn't glad that it's happened. This is the first time that you realize that Sawyer isn't one-dimensionally evil, but that he's actually complicated and is trying to do the right thing from his own point of view.
- When the marshall groans after being shot, Sawyer realizes that he has spent his last bullet and missed. Despite all of the morally questionable things that we've already seen him do, this is the first time that he looks afraid and ashamed. It reinforces the idea that Sawyer does have some compassion deep down, but also let's us see another aspect of what makes Sawyer who he is: even when he is trying to do the right thing, he is ashamed of himself for constantly screwing up.
- After Sawyer shot the marshall, he accuses Jack of not being able to do what needed to be done. But after he has missed, Jack goes into the tent and puts the marshall out of his misery. Here you see another pattern for Jack: despite whatever character flaws Jack may have, he is extremely capable, and doesn't shy away from conflict or hard situations.
- Perhaps most importantly, this is the first episode where Sawyer calls Kate "Freckles".


text:
With the Avengers Assembling in Disney Infinity 2.0, it's time to speculate on what other Marvel super heroes fans would like to see. Keep in mind that this game is marketed towards a younger crowd so it's unlikely we'll be seeing Painkiller Jane or any of the Young Avengers anytime soon.
That said, with the current Marvel cinematic universe, the on-going Marvel cartoon shows, and the Marvel comics characters that are officially part of the Avengers initiative there are quite a few characters to choose from. Here are some of my favorites.


text:
- This event has passed.
Intro to Permaculture Design I : Winter – The Seeds of Change
March 19, 2017 @ 10:00 am - 1:00 pm
Please join us March 19th for the inaugural workshop in our Introduction to Permaculture Design Series, part of MUD's 2017 Backyard Sustainability Workshop Series.
This course, The Seeds of Change will present the foundations of Permaculture design as science, art, and as a lifestyle. Permaculture will be presented as an analytical guidance system for creating and implementing solutions through intentional observation and action, working with-in nature and with the rhythm of seasonal cycles, in order to create sustainable individual and societal relationships with people, planet and profits.
Curriculum will cover the 12 Principles, 3 Ethics, and 7 Layers of Permaculture; introduce methods for observing and understanding patterns, energy-flows and system relations, cycles and seasons; site mapping and design strategies, for annual and perennial plant-based Permaculture in an urban setting; an introduction to management of soils, water and light; Agro-ecology and landscape-level analysis to identify and manage microclimates and edge effects, in order to increase productive potential and diversify the number of species and ecological relationships present within the system.
Following the presentation, students are invited to share ideas and information regarding Permaculture as well as participate in the process of planning and planting for MUD's 2017 Gardens, with discussion topics including applications and practices of seed saving, plant breeding, planting etiquette and garden design strategies, as we plant seedling trays for MUD's Greenhouse.
You can register for one or more workshops by paying through MUD's Square Marketplace.
Each Individual Workshop is $20 MUD members, $40 nonmembers. Or, sign up for the whole series to receive $5 off per workshop. Contact email@example.com if you need a payment plan option for the whole series.
Reserve your spot today! Click this link to sign up at the MUD Square Marketplace.


text:
Homeland Recap: Defector Detector
In a vacuum, "Oriole" was a solid, suspenseful episode of television.
Question for discussion: How interested were we in watching a TV show about terrorism this weekend? Usually we're fascinated by entertainment that seems "real" or "fact-based," or offers at least an ersatz reflection of things we know to be true. But I'd argue that realistic entertainment still feels far-enough removed from reality that we can safely enjoy it without trigger warnings. And then sometimes you're watching a show, and in it, a group of men are planning a jihadist strike against a major European city, and you just feel like clutching your stomach and sitting on the floor. Homeland has always prided itself in using international terrorism as a factual foundation for its pulp-enhanced story lines, but weeks like this one make it difficult to enjoy.
"Oriole," in a vacuum, was a solid, suspenseful episode of television. After last week's Saul-centric interlude, this episode marked a return to Carrie's endlessly frantic existence. If you were hoping to learn just what was in those documents that caused this huge Russian-German-American fracas, well … after poring through the documents all night, Carrie doesn't find a smoking gun. Just a CIA "while you were out" message from an Iraqi man trying to reach her. She tracks him down to find out what he wanted to tell her, and it was that another CIA asset she'd once thought was dead was actually alive. Just more breadcrumbs!
Next thing you know, she's donning her fright wig and heading to Amsterdam, where she tracks the former asset down, breaks into his home and steals his laptop just as he is apprehended by armed thugs, who then opened fire on Carrie. Though we're still left with questions about what, exactly, Carrie has gotten herself into, the suspense remained top-notch. At least there was that.
The most important element of "Oriole" was Allison's increasingly illuminated machinations. If it wasn't already clear, this episode confirmed that she is indeed KGB — or SVR, though her Russian boss seemed okay with either term — and her lifelong infiltration of the CIA is regarded by Russian higher-ups as heroism worthy of putting her in charge someday. Despite how competent and shrewd Saul and Carrie have been over the years, Allison still managed to convince each of them that she's a reliable ally, and on advice from her KGB superior, she even managed to manipulate Dar Adal into releasing Saul.
Later, in his hotel bathroom, Saul turns on both faucets and whispers to Allison everything he knows: Carrie was alive, he'd given her the documents, and so forth. And in one of Allison's most human moments yet, she greets this news with waves of nausea, eventually sitting by herself on the bathroom floor. We still didn't know why it was so crucial to keep Carrie separate from those documents, but Allison's panic was a nice demonstration of just how high the stakes seem to be.
Because Saul had crossed the CIA and utterly destroyed his friendship with Dar Adal — "You will remember this moment … and it will shame you," he says — he's now staring down the barrel of imprisonment in the Langley catacombs. The beauty of his character is that it was fully plausible that he'd accept this punishment with a bowed head, but we'd also believe it if he chose to fight his way out of impossible circumstances. So, when the agents escorting him to the airport were suddenly overtaken by masked men with Uzis, we got a sudden, classic example of the latter. Saul had called in a favor with the Israelis and officially "defected" from the United States. Didn't see that coming! Committing treason was probably not particularly high up on Saul's to-do list, but at least now it affords him the opportunity to exonerate himself, and maybe even to help Carrie.
Oh, Quinn. Last week we saw him accidentally fall in with some jihadists at a safe house, during which he shamed them for plotting to commit terrorist acts in Berlin. He then murdered their leader with his bare hands, which, in terrorist circles, is a bit of a mic-drop moment. So, this week, they casually ask if he'd be willing to sneak them back into Syria. He almost laughs in their faces … before realizing it could be a good idea. During a quick sandwich date with Dar Adal, the two agree that he should pretend to bring them to Syria, then take the opportunity to assassinate one of the dudes' uncles, who is a notorious terrorist leader. So yet again, Quinn happily signs up for certain death. Classic Quinn!
Again, "Oriole" was full of fascinating character moments and crackerjack suspense sequences, and on the whole brought together disparate elements in a highly satisfying way. But, given the tragedies of the past week, it's entirely reasonable to feel disquieted by the episode's subject matter. As Düring explains to Carrie, "You're either born with wings or not." Like its namesake, "Oriole" has wings, but sometimes even birds don't feel like flying. I'm not sure I know what that means, or what anything means, but that's just how the world is sometimes. Homeland seems to understand that, too.


text:
Calum Dickson
I grew up in rural Scotland and so was fortunate to be surrounded by an abundance of wildlife and beautiful scenery. My parents and grandparents spent a lot of time educating me in the beauty and creatures of the area but like most kids I took what was around me for granted. After my school years I left rural Scotland for the big city in search of education and work.
City life was great but I missed the freedom of the countryside and being able to look out the window at the Galloway Hills and to see all its wildlife………………
Now a father myself I have given up city life and these days live in hertfordshire which is a great place to bring up a child and for wildlife photography.
- 4,381 Affection
- 79,794 Photo Views
- 534 Followers
- 51 Following
- Hertfordshire


text:
Separate names with a comma.
Discussion in 'The Edge of the Forum' started by Juanmatron, Nov 7, 2010.
Never trust an outlet that can't spell "Market".
I really don't think a single typo of one key for the key right next to it fits the word "epic".
5 years developing it to then do it multiplatform. It's an epic fail.
I think that's a website fail and not Gran Turismo 5.
Hey, I know that swirl! We have the same store here
Actually its the stores name and its international aswell not just local and if it was local its spanish so no, your comment is invalid ;p
What Goli said
I think the only fail here is Juanmatron.
How do you mean irrelevant.. You, sir, have a fail day! Welcome at the club...
Loving the grammar :3
Silly drunk person
What? I don't see anything wrong there besides the y typo for & (and since it's lowercase they would have hit 7 anyways.. And if you say it's some foreign language it's a stupid one...)


text:
Drugs: From Discovery to Approval
Drugs: From Discovery to Approval
Mar 2005
368 pages
DescriptionStatistics show that out of five thousand compounds with initial promise, five will go into human clinical trials, and only one will become an approved drug. This tiny fraction illustrates the huge complexities involved in bringing a drug to market, a process that brings together scientific research, medical ethics, business, and various regulatory agencies.
Drugs-From Discovery to Approval presents a clear, step-by-step overview of the entire process. Using simple language, this comprehensive guide introduces basic concepts, then moves on to discuss disease target selection and the discovery processes for both small and large molecule drugs. Subsequent chapters explain preclinical studies, clinical trials, regulatory issues, good manufacturing practices (GMPs), and perspectives on the future. Coverage also includes:
* A helpful listing of current FDA and European guidelines
* A special section on regulatory authorities and processes in Japan and China
* Rich illustrations throughout, including more than ninety figures and tables
* Useful appendices on the history of drug discovery and development
* Representative examples of drug mechanisms in action
Written for professionals in the pharmaceutical industry, and readily accessible for students of pharmacy or medicine and others interested in drug discovery, Drugs-From Discovery to Approval represents a practical and approachable reference on this important process.
Chapter 1. Introduction.
Chapter 2. Drug Discovery: Targets and Receptors.
Chapter 3. Drug Discovery: Small Molecule Drugs.
Chapter 4. Drug Discovery: Large Molecule Drugs.
Chapter 5. Drug Development and Preclinical Studies.
Chapter 6. Clinical Trials.
Chapter 7. Regulatory Authorities.
Chapter 8. Regulatory Applications.
Chapter 9. Good Manufacturing Practice: Regulatory Requirements.
Chapter 10. Good Manufacturing Practice: Drug Manufacturing.
Chapter 11. Future Perspectives.
Appendix 1. History of Drug Discovery and Development.
Appendix 2. Cells, Nucleic Acids, Genes, and Proteins.
Appendix 3. Selected Drugs and Their Mechanisms of Action.
Appendix 4. Pharmacology/Toxicology Review Format.
"…a concise, no-nonsense overview of drug research and development from target identification to product manufacturing." (Journal of Clinical Research Practices, October 2007)
"…an exciting and novel text…excellent and essential text…" (Journal of Chemical Technology and Biotechnology, Vol. 80 (8), August 2005)
"…an exciting and novel text …provides a concise, yet comprehensive survey of the entire drug development process." (Journal of Chemical Technology and Biotechnology, 2005; Vol. 80, 964-965)
"…a practical reference source on this important process." (Journal of the National Medical Association, Vol.97, No.3, March 2005)
"…this book is appealing...the information...should provide a greater understanding of social and ethical concerns regarding modern medications in a complex world." (Journal of Pharmacy Technology, November/ December 2004)
"...a concise guide to the subject...readable and clearly written...can be recommended for the general reader..." (Pharmaceutical Journal, 24 April 2004)


text:
Wooley (1985) indicated that architects are vital players in the planning arena because they can use figures, drawings and other visual aids as a means of thinking through seeing. In the same manner, the urban design planners are the ones who can effectively connect the concept of beauty (aesthetic) with usefulness (practicality), and structural integrity (engineering) with other positive attributes essential to a satisfactory physical environment e.g. robustness, permeability, etc. (responsiveness). These are interlinked concepts, and the achievement of a good balance of these concepts is vital to the success of the urban development plans.
According to Bentley, et.al. (1985), structures and spaces should offer its users a wide array of choices in order to maximise their benefits. The built environment should provide its users with an essentially democratic setting. Again, among all those involved, it is the urban design planner who is the most capable one in ensuring this aspect given his background discipline.
A good urban design planner does not strictly need well-honed skills in design analysis. But he/she certainly has to know what to look for and what questions to ask. He/she always must recognise that there are limits to his/her own experience and outlook and therefore, working with others and consultations with those whom the urban design and plans are intended for will always have better results in terms of responsiveness. Working with other players too is important. Moreover, they must go out and be in touch with the reality that is happening outside of their office. What is learned in the four corners of the classroom should be supplemented with hands-on experience in the field. That "experience is the best teacher", is true.


text:
The story of the Animal Rescue League of the Palm Beaches is told in three bronze plaques that hang in the building`s lobby. One honors a woman who donated money for the building. Another honors a woman who donated the land. A third, smaller plaque recognizes Mary Jane Davis for her ``vision, energy and perseverance.``
Nice enough words, to be sure, but they don`t really tell the story.
The Davis plaque should read, ``Thanks, Mary Jane, for cleaning all those disgusting cages.`` Or maybe, ``Hats off to Mary Jane for giving the dogs their distemper shots.`` Or even, ``Cheers to Mary Jane for hanging in there and working for 37 years when a lot of other people would have given up.``
You get the idea. Somebody in every charity organization has to do the dirty work, and Davis happens to be that somebody.
She has seen the league through three addresses and remembers its most humble beginning when animals were housed in orange crates on a piece of land near Palm Beach International Airport. Then the league moved to a building near Tamarind Avenue in West Palm Beach, a neighborhood so rough that some league members didn`t want to go near it.
``We had no money, no vet,`` she says, recalling the league`s early days. ``We had a shortage of help. We had a shortage of everything.`` When a distemper outbreak threatened the dogs` lives, she took needle in hand and gave the animals shots. When the place needed cleaning, she did that, too.
``Without her efforts, particularly in the early days, there would be no Animal Rescue League,`` says George Hulme, the executive director. ``She would do anything.``
The league has gone from handling a few animals in orange crates to caring for 200 cats, dogs and birds in 26,000 square feet of building space on 9.8 acres on Military Trail in West Palm Beach - the league`s new home since last fall.


text:
Mother's Day is Sunday, May 10. At Wisconsinmade.com we can help you find the perfect gift to let Mom know you are thinking about her. You can choose from a wide selection of gourmet foods including kringles, gourmet chocolate, and gift baskets. We also have outdoor and garden gifts along with home and office gifts that your mother will enjoy.
To further assist you with your shopping needs, our personal shoppers have selected five popular Mother's Day gifts for you to consider in our online Mother's Day Gift Guide.
Wisconsin State Maple Cutting Board
Mother's Day Kringle and Coffee Gift
Deal of the Week
This week, enjoy 20% off
Suzy's Four Flavor Cheesecake Sampler.
Suzy's Four Flavor Cheesecake Sampler offers you a delicious dilemma--choosing which of these Wisconsin Cheesecakes is your favorite! With Suzy's Four-Flavor Cheesecake Sampler, you can enjoy three perfect slices each of New York Style Cheesecake, Chocolate Amaretto Cheesecake, Black Forest Cherry Cheesecake and Chocolate Caramel Pecan Cheesecake. Order one 8 inch Cheesecake Sampler and enjoy four fantastic cheesecake flavors! This delicious Wisconsin cheesecake ships in crush-proof packaging.
Featured Artisan
Rowe Pottery
Customized Pottery
Rowe Pottery was established in 1975 in Cambridge, Wisconsin. In the late 1970s, as a two-person pottery studio and shop, sales were made through art fairs and the studio showroom. All the Rowe Pottery was made by hand on the potter's wheel and the pots were fired in the brick kiln out behind the small workshop.
Interest in collecting antique cobalt blue decorated salt glaze crocks and jugs was the inspiration to change the studio's pottery product line in early 1980. Rowe Pottery changed from it's original style of pottery to making museum quality reproductions of Early American salt glaze crocks and jugs. The value of early crockery was skyrocketing and quality adaptations of the early designs were not available.
Rowe Pottery, making salt glaze pottery for years, knew many of the secrets of this type of production. The American country home decorating movement provided an eager customer base to grow the studio into a viable business. Today, Rowe Pottery Works still makes several styles of pottery including the ever-popular salt glaze stoneware.
In keeping with the character of salt-glazed stoneware, Rowe Pottery pieces are not only decorative, but suitable for baking and serving. They go from oven to table top, and the interior glaze allows for easy clean-up. All of Rowe Pottery's salt-glazed pieces are dishwasher, microwave, and oven safe and lead-free. Rowe Pottery offers a variety of items from their salt-glazed stoneware line including bowls, crocks, pitchers, vases and dinnerware. Some items may be personalized or custom ordered. All are handmade with the quality craftsmanship that is the essence of Rowe Pottery.
What customers are saying...
"The time and effort that went into the crock I purchased for Christmas was incredible. I couldn't believe the detail." - Doris on the Rowe Pottery Personalized Heart Crock.
"I ordered this for my boyfriend in CA. They arrived on time, in good condition and he said they are delicious. I hope he orders some for me!" - Quizzly on the Artisan Candy Bar Assortment.
Check out our blogs!
See what we're talking about this week on Edible Antics!.
You can also check out A Gourmet's Wisconsin Cupboard for ways to celebrate with Wisconsin foods.
If you have any questions, contact our friendly, Wisconsin-based customer service representatives at 1-877-947-6233. We are here to help you with your food and gifting needs.
Happy Shopping!
The Wisconsinmade Team


text:
Documents are only in Finnish.
More detailed instructions on how to register a travel agency according to the new Package Travel Act per 1st July 2018, will be published August 2018.
To bank account in Pohjola: IBAN: FI15 5000 0121 5029 33 BIC: OKOYFIHH
Companies (Oy, Ky, Ay, Ry) and cooperatives submit the following appendices:
Private traders (Tmi) submit the following appendices:
Finnish Competition and Consumer AuthorityP.O. Box 500531 Helsinki
Tour operators are charged an annual supervision fee starting from the year they registered.Supervision fees
The application processing time is between two and six weeks*. You can expedite the processing by ensuring that the requisite information and appendices are included with the application. When the Finnish Competition and Consumer Authority has received the registration notification, you will be contacted about the amount of any security. Security templates
If you do not collect advance payments or sell gift cards entitling to the purchase of a package tour, your business may be exempted from the obligation to lodge a security.A supervision fee is also charged from the year of registration on the basis of the amount of the security estimated in the registration decision.
Registered companies report on their activities to the Finnish Competition and Consumer Authority once or twice a year, or when requested.Reporting instructions for registered travel agencies*An entry certificate pursuant to the Provision of Services Act (1166/2009) is not submitted with respect to the registration application, as the registration decision is made within approximately two weeks of receiving the security that is a condition for registration.
The tour operator is always responsible for the entire package tour pursuant to the contract. When payments are collected from consumers in advance, a security is required for the activity. If package tours are paid after the trip, the tour operator may be exempted from the obligation to lodge a security.
*Advance payments are booking fees collected from consumers before a trip and final payments, including the remittances paid by the tour operator to their subcontractors.
A retailer sells the package tours of a tour operator in the register of package travel companies. A retailer of a foreign tour operator sells on behalf of its foreign principal package trips organised by this party.
Incoming activities, i.e. trips to Finland, do not require registration in the register of package travel companies. The business in this case must be organised in such a way that bookings are made and trips in their entirety are sold in the foreign country of origin.


text:
Dancing Party Animals are not your average dancing animals, these are animals that want to party.
We spotted them at CES as we trawled through the halls trying to find more serious news and products to report on, and couldn't help but find ourselves stopping to watch these critters in action and have since played the video over and over again to catch those moves.
Coming in a range of different animal guises from dogs to bears to squirrels, the plush creatures dance to the beat of your music.
But rather than your having to provide the speakers, the Party Animals come with one built in, allowing you to plug in almost any music source to enjoy to, well, get the party started.
Costing $35 in the US, we have to say Sandy the loveable dog is our favourite.


text:
It's becoming increasingly clear that 2008 will be a catastrophic year for the US economy, and therefore probably for that of the world as a whole. The reasons boil down to two: continuing and snowballing fallout from the subprime mortgage fiasco (exacerbated by an orgy of debt-leveraging), and record-high, continuously advancing oil prices. This brief portion of the February Museletter is so topical it bears immediate posting.
early November, 2007, the Commerce Department's Bureau of
Economic Analysis (BEA) announced the United States had achieved a
third quarter Gross Domestic Product (GDP) of 3.9 percent. That
number was later updated to 4.9 percent. Those numbers set off my
"reasonable test" alarm. How, I wondered, with an
accelerating rate of inflation and declining economic activity, could
the United States turn in such a stellar performance? The
BEA's report flunked the reasonable test.
Is institutional deception embedded in public policy? With an accelerating rate of inflation and declining economic activity, how could the economy of the United States manage to achieve a high growth, low inflation, performance?
Community and monetary economist Thomas H. Greco, Jr. gives a presentation in Sebastopol, California about creating alternative currency and exchange systems.


text:
|Page (1) of 1 - 04/27/16
|email article
|print page
April 27 -- Larry Fink, chief executive officer at BlackRock, talks with Erik Schatzker about political dissatisfaction around the world and the promise of fiscal policy stimulus. He speaks on "Bloomberg GO."
|BlackRock CEO Fink: Globally People Feel Left Behind
Source:GrabNetworks (c). All Rights Reserved


text:
Timor – De Vrienden Van Amstel Live!
De Vrienden Van Amstel LIVE! is a very popular annual event in the Netherlands. The show, that celebrated its 15th anniversary in 2013, annually attracts for over 100.000 visitors. Among the distinctive set, Holland's best artists perform in this unique format which is broadcasted on national television. Besides performing as a solo and lead dancer, I've choreographed and co-created the opening show. Introducing the iLuminate light suits to such a great crowd gave me a real kick. Seven shows in a row in a sold out venue.


text:
Alien found in India have a look at the pictures and video
|alien found in India photo true or hoax no one knows, source via - google search, India news.
Alien found in India:-
An alien humanoid has been found and photographed in Jodhpur, India. This took place in Jodhpur's Bawadi village in Rajasthan, where the locals were digging a tube well looking for water. They were shocked when they found this human-like alien.
|weird body of alien found in India, source via - google search, India news.
The creature looks human, but a little reptilian as well, with four fingers on each hand, but no thumbs.
This is very weird are aliens also hunting to search the earth and how can such a creature be found this is big question now and no one know what to say about this.
Wait For The Video To Load


text:
Our next guests have sold more than 16 million albums worldwide, as members of the band "3 Doors Down". They're releasing their Greatest Hits Album in just 3 days! But before they do they'll kick off a new tour in Tunica, with a special show to help kids all over the country have a "Better Life". Chris Henderson and Todd Harrell are here.
- Benefit Concert
- For the Better Life Foundation
- 3 Doors Down & Daughtry
- Saturday 6 p.m.
- Horseshoe Casino Tunica, MS
- http://www.horseshoetunica.com/
- https://www.facebook.com/HorseshoeTunica
- http://twitter.com/Horseshoetunica


text:
Yo dogg that bitch lauren is a hoe. She "get around" wit all the brothas in the hood.
by the niiga that kno wutz up March 19, 2010
n. A person, usually a woman, who engages in promiscuous sex, meaning that they often change sex partners.
Lauren: "I heard that Monique screwed three different guys last month."
Jess: "She is such a get-around!"
Jess: "She is such a get-around!"
by ?..? August 03, 2007
That female can get around!
by Ryan "Homie G" October 04, 2003


text:
Serving Palm Bay
1300 Palm Bay Rd NE Ste 3
Palm Bay, FL 32905
Main (321) 300-1356
Business Hours
Monday: 9:00am - 5:00pm
Tuesday: 9:00am - 5:00pm
Wednesday: 9:00am - 5:00pm
Thursday: 9:00am - 5:00pm
Friday: 9:00am - 5:00pm
Saturday: Closed
Sunday: Closed
Payment Accepted
Cash, Check, MasterCard, Visa
More about Miracle-EarMiracle-Ear is the brand Americans have grown to trust when it comes to hearing aids. With premium service in the Palm Bay, FL area, the latest technology, and the most discreet hearing aids in the market, Miracle-Ear is here to help.
Related categories for Miracle-Ear
Add your review below
Is your business listed correctly across the web?
Copyright © 2018 Topix LLC


text:
A great start screen for the operator OTT interface. A quick, attractive channel selection interface for cable or IPTV.
Let users browse channels visually and quickly. Or show them the rich TV packages they are missing.
Combining several video sources, the mosaic channel shows all the live channels and all the VoD streams in one or several screens, grouped by theme, age, etc.
- Mix live channels and movie trailers. Choosing a channel tunes in; choosing a movie trailer goes to the VoD portal, ready to purchase or view that movie.
- The same platform can simultaneously generate multiple channels in multiple formats (series channels, children channels, news channels...) both in MPEG-2 SD, MPEG-4 720p, MPEG-4 1080p.
The LOVEStv contents platform created alongside RTVE, Atres
June 27, 2018
Multi-camera Cinfo technology will allow cable operator R to offer all the matches of Xiria handball teams
On a ceremony attended by several sports authorities and fe
November 23, 2017


text:
The La Sportiva Kid's Stickit Shoe is a kid's climbing shoe for growing feet. The Stickit fits comfortably with a low asymmetry so your youngest little monkey can ease into climbing. The leather upper will stretch and the unlined slipper slides on quickly. The lacing wraps behind the heel for an adjustable fit, with knots that can be shortened or lengthened, securing shut with a frog-like hook and loop closure. The bright colors will pump them up and sticky FriXion RS rubber will have them climbing better than you in no time.
So sorry, but only 4 items are allowed for comparison, so we're comparing the first 4. I blame the gnomes and so should you.
Would you like to compare the products you have selected now?


text:
It looks like you're using an Ad Blocker.
Please white-list or disable AboveTopSecret.com in your ad-blocking tool.
Thank you.
Some features of ATS will be disabled while you continue to use an ad-blocker.
Originally posted by testrat
There is suppose to be a embryo preserved in a musem near the lake. Just like Champ in the US, this creature is protected by Swedish law.
Originally posted by jagskotpalme
I live there and most people don't believe in this lake creature. I don't and will not until there is some better proof shown.
The thing in the video looks more like a worm or something....
[edit on 16-9-2008 by jagskotpalme]


text:
As I listened, the biggest take away was the simplest.
In answering the question, how do I decide what to flip? Their advice was brilliantly simple:
"Ask one question:
What is the most valuable use of class time? Direct Instruction? Exploration? Discussion? Application? Assessment? Remediation?"
Then ask:
What can I time shift out of class to increase the value of face-to-face (class) time."What simple advice.
From webinars to web conferencing . . .
From Brick and mortar classroom to flipped classroom . . .
From virtual classroom to virtual assessment . . .
That advice is crucial.
Your scarcest resource is the time you have to spend with your students. It doesn't matter whether it is face to fave or virtual, you can't afford to waste it.
So, don't look for places to insert video or technology. Look for the place where you can maximize your resources.
If a video gets the content across, use it.
If a textbook does, use it.
When you do, you begin to realize that some students may prefer "sit & get." Others may like to read. Others experiment. When you realize that, you have differentiated your instruction, AND you can develop relationships.
Don't be locked into a mindset.
As a teacher of professional development in the area of online education, we need to be looking for ways to improve our delivery. Just because something is online doesn't make it good.
We need to be looking for best way to impact our students learning.
What's the most valuable use of your scarce student contact time?


text:
Becoming and staying focused on the task at hand is one of the most important things you can learn for your business, your career and also for your life in general. Multitasking is a great idea, however it's nothing more than wishful thinking. You simply cannot do more than one thing well at a time, if you need to get more done in less time let's have a look at some ways you can stay focused.
Use a Calendar
Everyone has a calendar, most of us on our smartphones and your calendar is your best friend when it comes to staying focused. Use it to make a list of the things you are supposed to do each day, and to set yourself deadlines and check-up points, to help make sure you're being effective.
If you have a to-do list, it's important to prioritize what you are doing so that you can do the most important things first. Everyone's priorities will be different. If you are a small business owner, your first priority each day should be doing the work that you need to do for yourself as your "first" client.
Turn Off Noise
Mobile phones, office phones, your email account and your social media networks are all distractions, turn them off and focus on each of things you're doing one hundred percent. Don't focus on the noise around you, emails don't have to be answered immediately and it's actually liberating once you learn and accept this. It's hard to do, but you'll find that the work your work on will be of a higher quality and they you'll get more done, faster.
Take a Walk
I used to walk, run all of the time and I must get back to it, exercise is one of the best things you can do prior to getting down to work, as it allows you to sort your inner demons out and to get your focus, harmony sorted as exercise allows you to clear your mind and gives you a tremendous sense of well-being.
Time Yourself
Try not to work for more than 90 minutes at a time without a break. Taking frequent breaks where you get away from your work or the project for at least five minutes will do wonders for your ability to focus. Now, don't use this time to check your email or social media, instead get away from your desk and do something else.
Stop Multitasking
Many people think that multitasking is a virtue, the truth is that it is very inefficient, cause's undue stress, and you don't get things done any faster. What you do get however when you are not focused, is lower quality and you can't get as much done.
Stop Checking Emails
Most people seem to think that an email needs to be read and answered immediately, they will often check their email multiple times per hour and often drop everything to check a new email when it arrives. It doesn't stop there when they are out, at home or away from their desk they use their smartphone to check their email.
I'd suggest you check your email just two or three times per day, because no matter what business you are in, you don't need to check more often. Let your clients know the times you check email, and set up an appointment system for clients to schedule phone calls. You might also like to delete that email app from your phone as I did many years back, this really is liberating.
Give Yourself Plenty of Time
Trying to do everything as fast as you can and over-scheduling yourself is a sure-fire way to become unfocused and build stress. Instead, give yourself more time than you think it will take so that you have plenty of down time. Being stressed out and rushing through things is a way to make mistakes.
Learn to give yourself time to do each thing that you need to do by turning off the noise and distractions, and placing your focus on "first things first." By narrowing your focus, you'll enjoy your day more and each moment more, because you'll shut down the noise that happens all around you and get to doing what needs to get done.


text:
Registration for the AP Courses is now available!
To register online , please click HERE.
In Step #1, please register for the course subject and whether you are taking the
class for credit or audit and pay the $150 deposit. This must be done by June 11,
2018. In Step #2, you will pay the AP tuition of $1119 and select your meal option.
The deadline for this is July 2, 2018.
Please call (570) 408-5615 with any questions.
Wilkes University, in cooperation with The College Board
will host AP 2018, a specially designed summer workshop for Advanced Placement (AP) teachers. This program is tailored for people who teach, or wish to teach, AP courses in the following fields:
- Biology
- Chemistry
- Calculus
- English Literature
- Environmental Science
- Physics C
- Statistics
- US History
Equal emphasis is placed upon pedagogical and subject content. The courses are designed to accommodate beginning and experienced AP teachers. Each course will review the latest changes and shifts in emphasis in the AP syllabus.
AP 2018 will begin Monday, July 16 with registration and breakfast in Wilkes' Student Union Building -- the Henry Student
Center. Classes will begin Monday morning and run until Friday afternoon, July 20.
A detailed schedule will be provided upon registration.
Instructors may assign preliminary reading, which will provide background for class discussions. Classes are designed to create an atmosphere rich with peer interaction and individual attention.
The courses offered in AP 2018 may be taken for 3 graduate credits or audited.
To earn 3 graduate credits students must submit additional assignments as directed by the instructor. Students taking the class for credit will also receive 90 ACT 48 hours. All AP 2018 participants will have access to the latest technologies and facilities in each discipline. AP 2018 is designed to be informative, helpful, encouraging, and fun. We hope you can join us!
For a list of places to stay in the local area, please click here.


text:
Available ebook formats: epub mobi pdf rtf lrf pdb txt html
Martin Vavpotic is an independent writer who has recently begun writing in English to reach more readers than his native language permits. So far, Clockworks Warrior is his only published book in English but he plans to change that as fast as humanly possible. Look for upcoming titles at Smashwords and other ebook retailers.
Follow my blog at: martinvavpotic.wordpress.com
Review by:
Yvette Pelger
on June 13, 2012 :
A marvelous story that gives your imagination wings.
Even though you enter an Entire new world; the brilliant combination of 'normal day object' versus 'fantasy' strikes a cord for your mind to build up from.
(reviewed 5 days after purchase)
Review by:
Ziga Valetnic
on May 15, 2012 :
A very interesting story that I have enjoyed very much. I would recomend it to anyone who like to escape to fantasy world from time to time and help fighting bad guys with courageous hart and cunning mind.
(reviewed 22 days after purchase)


text:
Tyres Pretoria – 073 271 0341
If you are looking for tyres in Pretoria we can assist with the following services:
No matter how good the car you're driving is, its overall performance is directly governed by the quality of its custom rims Pretoria and the grip they provide. It is not uncommon for road drivers to continue to drive on worn out tyres.
It is believed, that as many as 80% of the drivers have tyres that were either not cared for correctly or had issues such as incorrect pressure, damage or illegal tread depth. Your custom mags Pretoria play a vital role in your driving safety and their importance cannot be understated. It is absolutely essential that your tyres have the best possible tread for your specific climate/ situation you are in.
For example, in a wet situation, a tyre is worn out; the remaining tread cannot adequately disperse the water at the contact patch. What happens next is that a film of water is sandwiched between the tyre and the road surface. Once this happens the grip totally disappears, this is known as aquaplaning.
Climate change results in tyre tread differences. In tropical climates, custom alloy rims Pretoria degrade a lot quicker than in temperate climates, and more care should be taken in these climates to ensure that tyres do not fail. Tyres which are on seldom-used vehicles, such as trailers, are at the greatest risk of age-failure, but some tyres are built to withstand idleness, usually with nylon reinforcement.
"When should I replace my rims Pretoria?" This is a good question and an easy one to answer. Tyres have wear indicators that tell you when the tread is too low. Look closely at the shoulder of the tyre and you'll notice a number of marker arrows. These are about 30cm apart around the edge of the tyre and point to the indicators location. The wear indicators are custom rims for sale Pretoria, around 1.6mm high, in the main channels of the tread itself. Many automakers recommend replacing should be done often before tyres become 'bald', and several tyre manufacturers have called for bmw rims Pretoria to be removed from service 10 years after the date of manufacture.
A new tyre has about 8-9mm of tread depth, but as we drive the tread wears down. Once it wears down to the top of the wear bars it's time to fit some new rubber. When this time arrives it pays to talk with a tyre specialist about the type of rims for sale Pretoria that will best suit your needs.
So contact us today for all your expert tyre advice and assistance- the cost of tyres is quite minimal in comparison to the benefits that they bring.
We are the best tyres company in Pretoria so give us a call at: 073 271 0341 today!


text:
Roche pursues a new eye-care angle
Roche's bid to carve out space in eye care got attention with the Tuesday release of Phase II data about its experimental drug lampalizumab, which focuses not on the heated wet AMD or diabetic macular edema markets but on dry age-related macular degeneration. The treatment's target is even more specific, in that it is for geographic atrophy, an irreversible loss of retinal tissue, and is part of advanced AMD.
There are no approved drugs for geographic atrophy (GA). If Roche gets there first, it could give the drug maker some needed breathing room. It's been squeezed in the wet AMD space by Regeneron's Eylea as well as by off-label use of Roche's own Avastin, which is cheaper than Roche's own wet AMD drug, Lucentis.
Jefferies analyst Jeffery Holford wrote in a Wednesday research note that a high unmet need adds to the drug's appeal, and that even if Roche were not to lead in the space, the potential audience is large enough for competing treatments.
Results show the drug slowed GA progression by 44% after 18 months, among patients who received monthly injections, with efficacy surfacing six months into testing. Roche says the data showed "no unexpected or unmanageable serious AEs, no death or ocular serious AEs suspected to be caused by a study drug and no ocular serious AEs in study eye leading to treatment discontinuation."
This may be of note for those on the Roche beat, because Lucentis may be set to take another hit in the diabetic macular edema space: as noted by Forbes last month, Regeneron's Eylea may be elbowing its way into this Lucentis indication, with an added benefit other than efficacy. Unlike Lucentis, Eylea's label does not carry a fatality warning.The possible pipeline success is just part of what's been a contraction-expansion story for Roche this year. The 2013 narrative has included buying up hematology diagnostics firm Constitutional Medical Investors, landing priority review for its son-of-Rituxan cancer treatment, ending development of its diabetes medication aleglitazar over "safety signals and lack of efficacy," and cutting jobs in Indiana.


text:
Crest Hill: (815) 741-1700
Lombard: (630) 620-1980
Naperville: (630) 369-8700
Plainfield: (815) 577-9900
Elizabeth Reiser-Loeber, DMD
General Dentist
Treating patients at the Plainfield, IL Dental Office
Member of the Academy of General Dentistry
Member of the American Dental Association
Member of the Chicago Dental Society
Member of the Illinois State Dental Society
Member of the Dental Oral Conscious Sedation (DOCS)
Member of the American Dental Society of Anesthesiology
Certified Provider of Advanced Cardiovascular Life Support (ACLS)
Dr. Elizabeth Reiser-Loeber experienced what it was like to be embarrassed by her teeth at a young age. Her teeth were so bad that for many years she spoke and smiled as little as possible. She spoke so infrequently that her parents began to believe that she was in need of therapy! Her self confidence began to improve with the help of her family dentist and an orthodontist. Dr. Reiser's dentist had always taken exceptional care of her family's dental needs and worked within a strong belief of medical and business integrity.
Dr. Reiser was dramatically affected as her teeth were transformed to the beautiful smile she has today. She knew without a doubt that she would become a dentist. This was at the tender age of 14!
Dr. Reiser knows first-hand that a good smile has a dramatic affect on a person's self esteem and well being. Her personal experiences in the dental office were so profound that she decided that she would do her best to try to emulate them some day. She always liked, and even enjoyed going to the dentist and wanted to give other people the same experience.
Dr. Reiser received her Doctorate of Dental Medicine in June 2005 from Southern Illinois University – Edwardsville. For Dr. Reiser, dentistry is more than a trained art or a job; it is something she loves to do every day. "My favorite thing to do is transforming a person's smile. Whether that be fixing something simple, or a complex reconstruction; I take the time to listen to whatever the chief complaint is and address it accordingly." said Dr. Reiser
Dr. Reiser also recognizes the role that modern technology has in achieving these goals. Because of this she is constantly working to expand, not just her level of knowledge with regular training and professional growth.
Dr. Reiser resides in Plainfield, IL with her husband and two sons. In her spare time she enjoys gardening, camping, hiking, traveling and being outdoors. Her hobbies include cooking, baking, sewing and cross-stitching.
Dentists provide dental services as independent contractors; they are not employees of Advanced Family Dental & Orthodontics, PC or affiliated companies. Each office is advertised and marketed as a cooperative for dental services and providers.
A Little About Us
Advanced Family Dental & Orthodontics, PC & Affiliates is a full service general dentistry practice with specialty care in the areas of orthodontics, periodontics, oral surgery, cosmetic dentistry, dental implants, Invisalign and more.