text:
Shawn Santana
Title: President
About Me:
President of Vizzun Entertainment, Shawn Santana is a visionary and a leader.
NEW Featured Article:
Shawn Santana on 'Ohana and His Island Festivals. Click Here!
Story by Jill Reinhardt of KamaainaMagazine.com
Born and raised in Hawaii, Santana comes from a family background in entertainment and business; his father was a manager for one of Hawaii's hottest night clubs and his mother worked in the food and beverage industry. An entrepreneur from a young age, Santana started his first company after graduating from high school, Creative Art Applications, a custom dye cut decal business. The business was a successful venture, even more impressive in the fact that Santana is a self taught graphic designer.
In 1998, Santana sold his company and moved to Las Vegas in order to challenge himself with other business opportunities. Though he loved living in the mainland, Santana longed for island style entertainment and it was then that he decided to bring what he was missing from Hawaii to Las Vegas.
He found Vizzun Entertainment so that he could share the "aloha spirit" and island culture through music and entertainment. The Hawaiian Bash was the first of many successful concerts that Vizzun Entertainment promoted and produced, followed by the Pure Aloha Festivals, Kapena Jam and Da Kine Reggae Concert. My connection is the music, says Santana.
Working with artists such as Sudden Rush, BET, Fiji, Kapena, Bonafide, Fiji, Augie T, Santana saw an opportunity to further promote the talented artists of the Islands and created a studio and record label.
The concept of sharing the island spirit branched into the Pure Aloha clothing line.
Living in the islands made me who I am today, says Santana, who's goal is to keep the aloha spirit alive and give the children born in the mainland a chance to connect with their island heritage.


text:
Book your Classified or Display advertisement through advertising agency in Andhra Pradesh. We are an advertising agency booking ads for Andhra Pradesh Newspaper since last 2 decades. As an Advertising Agency we have served many clients based in Andhra Pradesh for their newspaper advertisement needs. Over the period of time our ad agency has grown immensely and has been recognized as a foremost service provider in the field of Newspaper advertising in Andhra Pradesh.
Andhra Pradesh abbreviation A.P. is one of the 28 states of India, situated on the country's southeastern coast. It is India's fourth largest state by area and fifth largest by population. Its capital and largest city is Hyderabad.
Andhra Pradesh has the second-longest coastline of 972 km (604 mi) among the states of India.
Andhra Pradesh's GDP for 2011 was approximately 5,67,636 crore, placing it second among the states. The state ranks second in terms of overall Gross State Product among all the states of the Indian Union.
As an Ad Agency we help you advertise effectively in all leading newspaper of Andhra Pradesh. You can always take help of our media experts to get the lowest quote and decide which newspaper would give you the best response among all newspapers of Andhra Pradesh.
Ads2Publish, the leading Newspaper Advertising Agency in Andhra Pradesh has incorporated all Andhra Pradesh Newspapers in our online booking system, therefore we ensure consistency in classified ad booking and availability of dates for all Andhra Pradesh Newspaper.

subset: commoncrawl


text:
Airstrike 1.0.2 download by Fifth Dimension Company
You are a pilot of the plane, your goal is to destroy the city, erase it from the surface of Earth. Game control is not easy, but very easy! The bomb hatch is always open, simply press ANY key and the bombs will start to fall. Beware of the high buildings - the parachutes you have are not many. For the lasybones we have a cheat-system, e. g. infinite parachutes, no going-down for the plane, etc. So, just run our game and see it for yourself. Have a nice bombing!
Tags: Airstrike , Crazy , Denis , Dimension , Dniepropetrovsk , Fifth , Poker , Sadoshenko , Ukraine
Similar software
AirStrike II 2.50 download by DivoGames Rough, cruel and intense helicopter 3D action game that makes you fly and fight over desert, water and industrial areas. 100+ land, air and water enemy units will make your life worse then hell. If you pass it, tell us how you did it. Free trial.
AirStrike II: Gulf Thunder 2.70 download by DivoGames AirStrike II: Gulf Thunder is a fresh sequel to AirStrike II, arguably the most exciting 3D indie helicopter combat action game ever released. The new add-on has 24 new levels and requires whole lot of desert flying. Free download.
AstroAvenger 1.70 download by DivoGames Looking for a space shooter that will surprise you? AstroAvenger uses an advanced upgrade and power-up system that allows you to buy new types of weapons, ammo, armor and batteries as you advance from one level to another.
Action Movie Creator FX 1.0 download by Action Movie Creator Create fantastic action movies with "Action Movie FX Creator".


text:
- Latest available (Revised)
- Original (As enacted)
There are currently no known outstanding effects for the Administration of Justice (Language) Act (Ireland) 1737, Section V.
Revised legislation carried on this site may not be fully up to date. At the current time any known changes or effects made by subsequent legislation have been applied to the text of the legislation you are viewing by the editorial team. Please see 'Frequently Asked Questions' for details regarding the timescales for which new effects are identified and recorded on this site.
Provided always, That nothing in this act contained shall extend to certifying beyond the seas any case or proceedings in the court of admiralty; but that in such cases the commissions and proceedings may be certified in Latin, as formerly they have been.
Annotations are used to give authority for changes and other effects on the legislation you are viewing and to convey editorial information. They appear at the foot of the relevant provision or under the associated heading. Annotations are categorised by annotation type, such as F-notes for textual amendments and I-notes for commencement information (a full list can be found in the Editorial Practice Guide). Each annotation is identified by a sequential reference number. For F-notes, M-notes and X-notes, the number also appears in bold superscript at the relevant location in the text. All annotations contain links to the affecting legislation.
Modifications etc. (not altering text)
C1Functions of court of admiralty now exercisable by Queen's Bench Division of High Court of Justice in Northern Ireland: Supreme Court of Judicature Act (Ireland) 1877 (c. 57), s. 9, Supreme Court of Judicature (Ireland) (No. 2) Act 1897 (c. 66), s. 6, Government of Ireland Act 1920 (c. 67), ss. 38, 40, 41, S.R. & O. 1921/1802 (Rev. XVI, p. 954: 1921, p. 1332), arts. 2, 7 and 1921/1804 (Rev. XVI, p. 967: 1921, p. 422), art. 5
Latest Available (revised):The latest available updated version of the legislation incorporating changes made by subsequent legislation and applied by our editorial team. Changes we have not yet applied to the text, can be found in the 'Changes to Legislation' area.
Original (As Enacted or Made):The original version of the legislation as it stood when it was enacted or made. No changes have been applied to the text.
Geographical Extent: Indicates the geographical area that this provision applies to. For further information see 'Frequently Asked Questions'.
Show Timeline of Changes: See how this legislation has or could change over time. Turning this feature on will show extra navigation options to go to these specific points in time. Return to the latest available version by using the controls above in the What Version box.
Access essential accompanying documents and information for this legislation item from this tab. Dependent on the legislation item being viewed this may include:


text:
*Chinese Whispers teams *schedule revised
Moderator: ACOT Employee
*Chinese Whispers teams *schedule revised
Here are our teams! The first swap day is August 16. Here is an example: I'm on team 5. I will send my layout to karen c. and I will receive one from emarie803. And then I'll begin working on lifting her layout for the next swap day!
Team 1
Team 2
Team 3
Linda S.
Team 4
Team 5
karen c.
Again here are the rules!!
Here is how you play:
It's a game that is set up in teams. The 1st week every participant chooses their own sketch and interprets it in a layout. On Swap day you pass your layout not the sketch to the next person in your group/team. You all have a week to interpret that layout in your own style and then swap again. Eventually you would have interpreted everyone's sketch and at the end, as in Chinese whispers you see the differences to each person's original sketch from everyone's perspective.
**PRIVATE setting must be turned on when uploading your layout to the gallery
**On SWAP day you send an image of your layout by Private Message to the next person on your team
**When swapping the layouts on Swap day, keep the original owner's name in the subject line of your pm
for example: on the first swap day I will name my pm "joannie's layout" and send it to jackie, who is next on my team. When she sends it, she will also name it "joannie's layout". Makes sense?
**Everyone PLEASE try to swap your layouts on time, you don't want to take time away from the next person
Schedule and Reveal date
August 8 Sign up deadline
August 9 Teams are announced
August 16 First swap day
August 23 Second swap day
August 30 Third swap day
FRIDAY Sept 8 SWAP AND REVEAL DAY
On REVEAL DAY
You will pm your 3 completed layouts (the layouts u made) back to the original 3 owners of the sketch (that is why we need to name those pm's). Once the owner receives all 3 layouts from her teammates. I will have made a new post for each team's reveal. You will need to put the layouts in order, by the SKETCH, your layout version, and followed by the others on your team in order (sketch AND 4 layouts).
If you are completely confused...ask me questions. Since this is our first go of this we will probably hit a few bumps!
Last edited by joannie on Mon Sep 04, 2017 6:29 am, edited 4 times in total.
Re: Chinese Whispers **teams
This is going to be fun! And I'll no doubt screw it up first!! DUH!! Thanks for doing this Joannie!
Re: Chinese Whispers **teams
I see I am on team 4, slot four. Does that mean that the first sketch goes to the top of the list for me?
Re: Chinese Whispers **teams
Awesome..so I work on my layout, and send it to hsblair on August 16th. I receive one from Retiree3 and lift it by Aug 23rd
~ Brandy Williams ~
Visit my blog - Brandy's Lab
Re: Chinese Whispers **teams
I had some time this afternoon so I already created my layout. With all my hubby's medical challenges, I figured I'd better do it now because who knows what will happen next!
** Chris **
My blog: http://mommomandpoppop.blogspot.com/
Re: Chinese Whispers **teams
Yes! and I see I left off your "423"....oops!
Re: Chinese Whispers **teams
Yep!! I hope I haven't completely confused everyone!
Re: Chinese Whispers **teams
Let's hope/pray hubby is done with his medical issues! I got my layout done early too! I knew I'd have company for the next week or two!!
Re: Chinese Whispers **teams
Oh how exciting!!!
Happy Scrapping!
Re: Chinese Whispers **teams
Re: Chinese Whispers **teams
How fun, Joannie, thanks for all your hard work organizing & explaining. I have my sketch picked out to work on at a crop this weekend Shout out to the cherries on Team 3!! LOL
Visit my blog - #InMyLife
Re: Chinese Whispers **teams
Thanks Stacy. I just hope this works like it's suppose to! lol!
Re: Chinese Whispers **teams
I'm excited! Ive been looking at sketchs and have it all picked out! I cant wait to start.
(Kristi) When life gives you scraps, make something with them. ~Author Unknown
Re: Chinese Whispers **teams
I need a "thumbs up" emoji!
Re: Chinese Whispers **teams
Melissa H.
Re: Chinese Whispers **teams
Re: Chinese Whispers **teams
I picked - or should I say FINALLY made a decision on which sketch I'd use last night, so tonight I plan on hitting the paper.
Just a little warning, though, for sending early. I was in a circle journal (well, many circle journals) and if we didn't send on or about the day we were supposed, mass chaos ensued. . . I'd suggest at least sending it with a "This is the layout for such and such a day" swap. Sometimes a gal gets two at once, when you do it that way. Just saying. . . (Not to be a wet wrap saying this, because I'm excited!!)
Re: Chinese Whispers **teams
I can see that happening! My brain is a little fried these days! I can see me confusing the layouts!
Re: Chinese Whispers **teams
Oh, I hope this does not get confusing. I plan to hold mine until the day it is due(or day before). Then send it on.
Karen in SC
2-page, multi-photo scrapper
Re: Chinese Whispers **teams
Visit my blog - #InMyLife


text:
Sexual assault occurs when someone is forced, coerced or tricked into sexual acts or exposed to sexual situations against their will.
Sexual assault can also occur when a person is unable to consent, such as if they are intoxicated or asleep.
Sexual assault or sexual violence can include rape, incest, indecent assault, sexual assault and sexual molesting.
Children or people who can't give informed consent can be sexually assaulted when someone uses their age, size, authority or position of trust to involve them in sexual acts.
Sexual assault can happen to anyone. Sexual assaults are often carried out by a person known to the victim. The majority of sexual assaults are perpetrated by men.
NSW Health Sexual Assault Services provide free information, counselling, court support, medical treatment and forensic examinations for anyone who has been sexually assaulted. They can provide testing and prevention for pregnancy and sexually transmitted infections. These services are based in certain hospitals and community health services across NSW. There is a sexual assault service in your area open 24 hours a day.
Anybody who reports being sexually assaulted to the Police or the Department of Family and Community Services should be taken or referred to their nearest NSW Health Sexual Assault Service.
You do not need to have reported the sexual assault to the Police to receive help from a NSW Health Sexual Assault Service, if you are over 16 years of age.
Contact your local Sexual Assault Service.
If you wish to report an assault to the Police, contact your nearest Police station. Police are well trained to provide assistance to people who have been sexually assaulted.
NSW Health Sexual Assault Services can also help facilitate this process.
If you wish to report an assault and the assault has just happened, it is better not to change your clothes or wash beforehand.
If you, or a person you know, are under 16 years of age and have been sexually assaulted, reports can be made to the Child Protection Helpline ph. 132 111 as well as to local police stations.


text:
Weighing in on the deaths of the two dogs this past week. I've read several articles and they leave me with some questions.
I could readily see the dogs being seized and quarantined until the owner was found and they were tested for rabies, etc. I could also see the owner paying fines and stipulations given for their return.
One question that does come to mind is why this one case garnered so much attention? Why would someone go to such lengths arguing for the deaths of these dogs?
As I can see it, there can be two options. One, to label a dog as vicious and apply stipulations for their confinement and the other for destroying the dog.
This dog owner had even agreed to take the dogs back to her property and not bring them again to Manatee County.
Were the dogs ever evaluated after confinement for aggressive behavior and a report made that lent itself to this decision?
One article even states they were "therapy dogs." Even some pit bulls and otherwise deemed "aggressive dogs" after they are removed from their fighting environments are retrained and go on to be adopted out and lead normal lives with their new owners.
Were these dogs afforded the same?
It's obvious the owner cared deeply for the dogs and was willing to do whatever it took to comply with regulations and to secure their release.
It's a shame the owner was not given a choice. Instead they were doomed to die?
These were dogs that unless it was proved beyond a reasonable doubt that they were vicious and would repeat this action again did not need to be destroyed. They should have been given that second chance!
Janice Cavileer


text:
Mint leaves
C035/3938 Rights Managed
530 pixels on longest edge, unwatermarked
Request/Download high-res file
Uncompressed file size: 108.1MB
Downloadable file size: 2.4MB
Please login to use the price calculator
Credit: VOISIN/PHANIE/SCIENCE PHOTO LIBRARY
Release details: Model release not required. Property release not required.
Keywords: alternative medicine, alternative therapy, aromatic plant, complementary medicine, food, herb, herbal medicine, herbal therapy, leave, medicinal plant, mint, no-one, nobody, phytomedicine, phytotherapy, plant, still life, unconventional medicine, vegetal
Licence fees: A licence fee will be charged for any media (low or high resolution) used in your project.


text:
South Carolina Unemployment
Do I qualify for unemployment benefits in South Carolina?
If losing your job wasn't your fault and your employer(s) paid taxes in your name, you can receive unemployment benefits if your year's income prior to the quarter you lost work meets a specified minimum. (They'll mail you about your monetary eligibility.)
To receive benefits, you must:
- be seeking full-time employment
- be able to work
- be available for work.
Employers fund unemployment insurance entirely. It is not welfare nor are funds withheld from your pay for these benefits.
Find Out If You Are Eligible For Unemployment Click this link to find out: Am I Eligible To Collect Unemployment Benefits?
Have Your Benefits Run Out? Click this link to find out how to get an unemployment extension: Unemployment Extension
Wages Determine Your Benefits
Wages earned doing one year of insured work—the base period—determine your benefits. Only wages earned from an employer covered by South Carolina employment security law count as base-period wages. Generally wages earned from construction, factory work, mills, shops, stores, offices, banks, mines, and other businesses employing one or more persons count. The law does not cover certain farm labor, certain domestic services in private homes, and several other employment types.
You cannot file for extended state benefits on this site. You must file in person at your local workforce center. Living outside South Carolina? Call 800.529.8339 to file for extended benefits. Extended Benefits are benefits available after you exhaust your federal Emergency Unemployment Compensation. The State Extended Benefits extends benefits for up to 13 additional weeks. State Extended Benefits are available for individuals who have exhausted all regular unemployment insurance and all Emergency Unemployment Compensation (EUC), First, Second, Third and Fourth Tier on or after February 15, 2009.
Filing Your Claim
- You must have earned sufficient wages in order to establish an entitlement to benefits. You will receive a determination in the mail advising you of your monetary eligibility.
- You must be able to and available for work and be actively seeking full-time employment in order to receive benefits.
- If you have quit or been discharged from your job, you may be disqualified from receiving benefits. Your claim will be evaluated and you will be notified of any disqualification that is imposed.
- You will not be paid for the first week you are eligible in each benefit year.
- Your continuing eligibility to receive benefits will be periodically reviewed.
- Unemployment insurance benefits are taxable.
Eligibility Requirements
You cannot file a claim unless eligible. Being eligible means you meet the following requirements:
- You're unemployed. Note: If you work less than full time due to being out of work and earn less than your weekly benefit amount, you are still considered unemployed. Remember, when filing your weekly claim, report all work you did and wages you earned that week. Plus, you still must be seeking full-time work.
- It was not your fault that you lost your job from your most recent bona fide employer. We define "most recent bona fide employer" as your most recent former employer where you earned eight times your weekly benefit amount.
- You are able to work.
- You are available for full-time work and willing to take any suitable work offer.
- You regularly report to the local Workforce Center as expected. If you know you will be away at reporting time you let the center know in advance. Failure to report puts your benefits at risk.
- You actively seek appropriate, full-time work. Failure to seek work jeopardizes your benefits. While we will do all we can to help you find work, you must make a consistent, ongoing effort.
|Find a New Job
|Lose Your Insurance?
|In Debt Too Deep?
|Your Future
|Job Interview Tips
Job Search Sites
|COBRA Health Insurance
COBRA Subsidy
|How To Get Out Of Debt
Bill Collectors & Your Rights
|Go Back To School
Start Your Own Business
How do I file for South Carolina unemployment benefits?
File your initial claim here: https://secure.sces.org/PDIC/GatewayServlet?hptAppId=ICFJREG&hptExec=Y
SC Unemployment Claims Processes
The SC Unemployment claims process consists of three steps. Understanding each step is vital. Before you file a claim, understand what each step does and how you can best file and register for work. Anytime you need help, refer to the information you find here.
The first step is the "File Your Initial Claim." The second step is "Register For Work." The third step is "File Your Weekly Claim." Each step makes good things happen for you and understanding each step's purpose makes things go smoother for all.
Step 1—Your Initial Claim
You file your first, or Initial Claim, per benefit year. When you make your initial claim, you can also register for work. It's an easy, automatic way to register for work. Your initial claim determines if you are eligible for benefits. File this claim in two ways: in person at one of the SC Unemployment offices, or online. After you make this one-time claim, it becomes Step 2, Register For Work. Register for work and file your initial claim now: https://secure.sces.org/PDIC/GatewayServlet?hptAppId=ICFJREG&hptExec=Y
Note: Once you file your initial claim, you'll receive a notice with your wages from all covered employers during your base period. We'll determine if your wages qualify you for benefits. If they do, you've established a benefit year. Think wages are missing? Report to your local unemployment office with documentation for missing wages.
Step 2—Register For Work
You register for work just one time and you must do it within two weeks of filing your initial claim. If you don't, you won't receive a check. The unemployment office expects and requires that you seek work on an ongoing basis. Getting you back to work is the top priority. You can register for work in three ways:
- Online—When making your initial claim you can also register for work. (They register you with South Carolina JobLink using information you give them). Register for work now: https://secure.sces.org/PDIC/GatewayServlet?hptAppId=ICFJREG&hptExec=Y
- Online—You can go to South Carolina MyBenefits and register yourself, much as you do in the step above. http://dew.sc.gov/claim-MyBenefits.asp
- In Person—Come to one of the SC unemployment offices and file online using their computers.
Step 3—File Your Weekly Claim
You file your weekly claim (A) to prove you remain eligible for benefits and (B) thus qualify to get a weekly check. You can file your weekly claim in three ways:
- In person at one of the SC unemployment offices
- Online (File online now) https://secure.sces.org/PDIC/GatewayServlet?hptAppId=ICFJREG&hptExec=Y
- Using your phone and the TelClaim System: 1.866.831.1724
South Carolina Unemployment Office Contact Information
SC Unemployment Websitehttp://dew.sc.gov/claim-land.asp
SC Unemployment Mailing Address
1550 Gadsden Street
P.O. Box 995
Columbia, South Carolina 29202
SC Unemployment Phone Number1.866.831.1724
Maybe We Can Help:
If you can't find the answer to your question, you can fill out the comment form below and I will answer your question ASAP, or you can ask the The Unemployment Expert.
Thank you for your help.
Am I eligible? I did not quit my job.
Just my opinion.
poc ? do i have to wait for a poc in the mail before filing?
Please tell me how to receive the replacement check.
Thank you.
Thank you
I submitted for unemployment on 8th of July, but the representative for some reason cant read that and believes it's the 10th despite their own website showing it. It took them 10 days, with myself complianing before they would finally do an intake, during which they told me the employer had 48 hours in which to respond.. On the 27th I contacted Regional Office via email where a Mrs. Tina Nutter responded and said she didn't know what the hold up was and was sending my file to the Benefits Department. On the 9th of augusta I went to my county unemployment office , a 30-35 minute drive one way, where I was told that SC has their own WRITTEN POLICY which states they are to process claims in 4-6 weeks. The kicker here is the fact the FEDERAL GUIDELINES states these claims to be processed in 2-3 weeks! Anyways, I was told by the head Office Manager/Administrator that my file was still waiting for a determination. At this time I have takin the following actions: contacted the Governor's office with no feedback in over a week. Contacted my Senator who told me it wasn't a federal issue therefore they wern't going to do anything, mind you their disregard to follow federal regulations. Have thus sent information to both the federal DOL, my local district representative. The only feedback so far has been by the Federal Dept of labor: talktosolis@dol .gov
Question: Is it worth trying to file for unemployment? this business prides itself on never having a past employee ever collect..i know I been there to see lots of employee's come and go and heard the comments about never paying out.
Thank you.
do my job the way it should have been done. I would forget things and not do things I should have done. I was way over stressed and overworked. I have been advised by several people, even my doctor that I should try to get disability. We all know how long that takes. Can I receive unemployment.
Add comment
Also, we welcome your comments -- please tell us about your unemployment situation. Tell your story. How did you get laid-off? Have you found a new job yet? Do you have any unemployment tips to share?
- -*-
PLEASE NOTE that your comment will not post automatically, but will appear after the admin has approved it.
- -*-


text:
Pitching a location letter to Film Investors can easily impress them when presenting your film proposal. Location. Location. Location. This is something we hear in the real estate world, but the same holds true in the world of independent film – film locations are an important selling tool.
A strong location can not only add great production value to your film, but also become a key selling point when correctly pitching a location letter to film investors.
It is just as important to pitch a location owner as it is to pitch investors. When writing a scene or storyboarding, you should have an image of how a particular location looks, and location scouting is designed to help you find that magical place. When you do scout the perfect location, it will be pristine, meaning no filming ever took place there before. This serves an independent filmmaker well; as the location owner may not be familiar with film production or the possibility they could be paid for use of their location. Most of the time, location owners are excited just to see a movie being filmed in their establishment, or the benefit of advertising their location to a large audience, as long as it doesn't interfere with their business. This type of soft film financing, securing your location at no cost, will impress investors.
Once you find the perfect location, how do you approach the owner? The simplest and most efficient way is via a location letter, followed by a phone call. This letter should be simple, to the point, and is a very successful tool in getting what you want for free. The location letter paragraphs should be structured as follows:
The point of the location letter is not to scare a location owner with all the details. Details will follow in the next conversation. Remember to use key words: donating, volunteering, low budget. The ultimate goal is to get them to give you the location for free.
A strong location can not only add great production value to your film but also become a key selling point when correctly pitching a location letter to film investors. Having a great location early on is more ammunition for your proposal when pitching to film investors. It shows you are already budget and finance conscious and on your way to making a great film.
Get the letter that gets you the perfect location to impress investors!
Speed through the learning curve and fast-track your way to film financing. Download our tools immediately to help you ace your business plan, easily crunch your numbers, find and pitch film investors and fund your film.Read More
Are you really ready for film investors? You must demonstrate you take film investors seriously before investors will be serious about you. Learn the key steps you need to prepare for, attract, find and secure investors.Read More
"Just finished post on our $1.5 million picture, Coming Through the Rye. I could not have raised this money or made this film without the materials you provided -- and for $99? The bargain of my career!"Read More
Get your FREE 8 Week Film Financing, Film Investors and Business Plan E-Course. Stay up to date on the latest Film Investors seeking projects, Film Making Tips, Film Grant and Festival deadlines and more.Read More


text:
Want to see a 360 degree view of the LG Nexus? Of course you do. Hit up the source link for the goodies. October 29th can't come soon enough…
Check out this 360 degree view of the LG Nexus
Source: Onliner.by
Want to see a 360 degree view of the LG Nexus? Of course you do. Hit up the source link for the goodies. October 29th can't come soon enough…
Source: Onliner.by
I totally want the official specs now please!
360 view is pretty neat. I'm liking the look alot of the lg nexus. Hopefully Google has some goodies to announce at launch!
Good lord that chrome trim is hideous! WTF.
That looks really clean. Wonder if there will be any surprises left on October 29th, with leaks like these. :) So no curved form and no 3 pogo pins? i forget now, does this have wireless charging?
The curves made it so nice…. I was really hoping they would keep with that idea…
im slightly less excited about the device
maybe they were not able to curve it with the new display being True
HD (high-definition) IPS Plus display. guess we will find out soon.
If you go to the source site and look at some other photos, you will notice a little dummy button looking area where pogo usually is. I'm thinking this is still a few steps away from a finished product. I highly doubt it will have access to screws on the bottom either, as seen in the other photos.
That's not a dummy button… that's the nano-SIM slot. No removable battery cover, remember?
Er… I meant micro-SIM…
Wow device looks great until u see the chrome trim. Hopefully it looks better on the white version. It looks strange and out of place on the black one
It looks nice but I keep telling myself I wanted more out of the design.
I like how the glass curves over the sides. I think it's a good look.
I would also like to see a thickness comparison w/ the iPhone 5. The slope going around the back should make it feel a little thinner than it really is.
Glass curves to the sides? Or is it just an illusion from the Chrome?
I can see what you mean, but I do think it curves a bit. Check out the first image in the gallery in the first article out of Belarus. The very far left side shows some change in the lighting before it gets to the chrome.
It appears to have a similar curve to the sides as the LG G2x did. It makes swiping from the sides super smooth.
the Chrome has to go…
The Chrome looks good. Plus i throw a cover on it anyway.
Good looking phone. I thought was okay, but now I like the fact the chrome isn't superfluous. I like the micro sd card slot on the side even more!
that's a micro sim card slot…
That's probably the sim card slot (non-removable back cover).
Who cares? This thing is DOA anyways with its non-expandable memory.
Ha, like the Nexus before it, right? ;-)
Because nobody bought the Galaxy Nexus or the Nexus S. *eyeroll*
Hey, where did the glitter go?
Chrome looks fine. I mean, it's not as wide as the Galaxy Ace's (hideous!).
It's okay. It looks too much like GNex though.
And it looks like it's going to have a non-removable battery? It has a micro sim slot at the left side, just like the one on top of One X.
I'm surprised no one has said it but I kinda like the idea of staying with one form factor. It gives the average consumer some familiarity. I.e. the all iPhones resemble one another. Different yet familiar
Looks awesome :D. Probably selling my gnex to a friend. Plus I'm turning 18 on Monday so birthday $$$, Lg nexus here I come
This POS is DOA!
Maybe I am alone in this, but I liked the squared-off look of the Optimus G… this reminds me of my Galaxy Nexus…
Did I hear correctly? there's no LTE version of this?
I think it's supposed to remind us of the gnex since it's a nexus device. There will probably be an lte version on launch
Verizon and Sprint will probably release an LTE version that will get updates with a delay of 3 months like they did for the GNex.
To bad the HTC One X+ isn't a Nexus… Its stillthe prettiest phone out there.
I hope they stop this 8 gb nonsense. Games, maps, recorded videos, movies and other media need room on the device. Streaming ota does not work if you are underway, it not even works in my home wlan. I have 16 gb and need to delete stuff all the time, never would go back to 8.
It's a good looking phone but I'm still venturing a guess that it's not a Nexus…
Looking back at previous phones, Nexus branded phones have all simply said 'Google' (Nexus One, Nexus S, Galaxy Nexus) on the back while T-Mobile phones with stock Android say 'with Google' (T-Mobile G1, My Touch 3G, LG G2x, LG Optimus T)
Do a Google search for the phones I've listed… perhaps it's the same reason it's showing up in 8GB/16GB flavours and not 16GB/32GB?
In one of the articles , it stated this phone has been with the guy for a few months, so it could just be a test phone and not the actual Nexus.
Looks nice, but I wish this was real :D
awesome :-)
Am I the only one who noticed that the Source included 2 pictures under the nexus slideshow which are, I believe, 2 pictures taken by the Nexus and which are really pleasing?
They look better than what we've seen until now but still crappy
Has anybody been able to clarify if the back is glass or plastic yet
The guy who leaked the device said it's some kind of plastic.
Bring it out in white and I am in..day one buy..hope to make it a combo with the rumored Nexus 10..
HTC One X+ here I come.
Well , LG ? Why LG ? Seriously.
Also , what do you guys think of the wish list this guy has posted about android 4.2 – http://esponential.wordpress.com/2012/10/04/top-5-features-we-want-in-android-4-2-key-lime-pie-or-whatever-itll-be-called/
I just need to know 3 things…
I refuse to accept this as the final design. It was looking alright in the previous leaks. But now with a good look at it… Giant wasteful bezel, the bevel that surrounds the back is so… old. Silver rim, visible in anterior view is a close reminiscence of Samsung Galaxy S3 and iphone 3g.
LG's own design wouldn't have been like this. It would have consisted of angular sharp corners, no overbearing silver ring. Kept thin and sleek. Wasn't the phone different with the benchmarked one? That one looked better and it had an micro sd slot.There are several prototypes, and I hope this isn't the final one.
Looks like the son of the Iphone 3


text:
The Championships start on Wednesday in Birmingham with the daunting thought of England having to compete with no seeded players for the first time and China, the sport's dominant force, looking to repeat last year's five-medal clean sweep.
Clark, who will partner Nathan Robertson in the men's badminton doubles as England bid to win a first home title since 2005, said: "Having no seeds isn't a great state of where English badminton is at the moment. But we were unseeded at the Singapore Open last year and came away with the title. Hopefully we can slip under the radar.
"The problem is that we have lost a generation. We've lost a decade where no players came through and now we are relying on youth after some high-profile retirements.
"We're at the age now where we don't believe you can play at the top of your game for the entire season and you need to peak for the major tournaments such as the All England."
However it's not all doom and gloom. Robertson and new mixed doubles partner Jenny Wallwork are beginning to blossom as a partnership while England's youthful outlook is led by 23 year-old Rajiv Ouseph, the world No 23, in the men's singles. That competition will also see two of the greatest players of the last decade, Malaysia's Lee Chong Wei and China's Lin Dan, go head-to-head.
Clark said: "We have some good younger players and that is the challenge for our coaches. We have an Olympic Games coming up and UK Sport demands very high levels. That is the kind of pressure they are putting on sports such as ours. We haven't delivered in the last few big events but we have to aim high."
Despite England being seedless, the National Indoor Arena is still expected to witness cacophonic outbursts from the sport's traditionally-noisy spectators over the five days - especially from the Asian fans.
Clark added: "I find that it always lifts me. If you can silence the crowd then you know you are doing well.
"However many thousand Indonesian and Chinese fans turn up, though, they will always be outnumbered by the Brits."


text: Extraordinary security measures were used Thursday in Cook County Criminal Court when Jeff Fort, leader of the street gang El Rukn, appeared for legal motions in a murder case. A special elevator was designated, barricades were set up, an extra metal detector was installed and more than 20 officers lined the courtroom as Judge Michael Toomin heard motions in the June, 1981, murder case involving Willie ``Dollar Bill`` Bibbs. Fort`s lawyer, Thomas Peters, argued that his client could not get a fair trial in that atmosphere, and the judge said he would address the issue before the trial.


text:
Our mission at Algarve Property Shops is to offer our clients an opportunity for us to manage their properties to the best of our abilities so they can achieve their goal whether it be selling their property or renting their property. We will promote their property in the most suitable websites and we will endeavour to find the best possible result for them. We also can help with the upkeep of the properties through our list of reputable local contractors which we can have available for all eventualities .
Yours Truly,
The Management Team
Pola Wendy and Mick .


text:
Welcome to
Holston Camp and Retreat Center
MISSION: To provide a safe environment to experience a transformation of mind, body, and spirit within a community of faith.
Since 1959, Holston has offered a summer camp for kids who are seeking a refuge from the seasonal heat and a sanctuary for spiritual, mental, and physical growth. Now, as a year-around facility, we welcome children of all ages to respond to a higher calling in the beautiful wooded mountains of Holston Camp and Retreat Center.
Letter to Parents 2018
from Jim Austin, Director


text:
A bad credit history can severely reduce your options to not only borrow further, but may affect phone, utility company and tenancy contracts. Mortgages and even employment prospects may also be affected, as some employers are now checking prospective employees credit ratings! CCJs,(County Court Judgements), late and defaulted payments as well as bankruptcy orders, will all show up on your credit history and will cause difficulty securing further credit. Also, any missed credit card payments, direct debits for utility bills, or similar obligations, could add another 'black mark' against your name on your credit file, that is very likely to cause you problems for you in the future. Here at Discharge Debt Class, we understand what it feels like to be in debt and have a poor credit history, because everyone who contributes to the site has been in debt at one time or another and has successfully overcome the situation, using the information contained on this site.
Will I ever have Good credit again?
Yes, is the short answer. There are basically two ways to repair your credit. On the practical level you can have an A-rated credit report within a year or so of even bankruptcy. Why? Because lenders are much more interested in your present circumstances than what happened to you 3 to 10 years ago. Rebuilding your credit can be done rather quickly through a systematic plan, and a little perseverance. Keep in mind that positive credit information stays on your credit report forever and negative information for six years, at the most.
Rebuilding your Credit History
You can challenge your credit rating on a number of areas. You can show them our letters that the debt was never verified, if you used our Administrative Process on your creditor. Challenging your credit file entries can be effective because the credit agencies are often too busy to re-verify the item you challenged within the time limit and therefore will remove it. Also, because of human error, correct information can be inadvertently deleted.


text: San Bernardino, CA Premier Family Law Firm Our San Bernardino Family Law Firm is located in San Bernardino County to better address your family legal needs. We are available Monday through Friday from 8:00AM to 6:00PM PST. Please feel free to contact us via phone for a free case evaluation from a legal professional at +1 (800) 968-5313. Or click below to fill out a form for a Free Case Evaluation. Free Case Evaluation Contact info Address 323 West Court St. # 306 San Bernardino, CA 92401 Phone (909) 743-6113 Toll-Free (800) 968-5313 E-Mail firstname.lastname@example.com Legal Services we Offer in San Bernardino, CA Family Law Read More Restraining Order Attorney Read More


text:
Yurchenko (vault)
This article includes a list of references, related reading or external links, but its sources remain unclear because it lacks inline citations. (August 2015) (Learn how and when to remove this template message)
Yurchenko is the name of both a specific vault and a vault family in artistic gymnastics. The Yurchenko was named after Soviet gymnast Natalia Yurchenko.
In a Yurchenko vault, the gymnast does a round-off onto the springboard and a back handspring onto the horse or vaulting table. The gymnast then performs a salto, which may range in difficulty from a simple single tuck to a triple twist layout.
Any vault with a roundoff-back handspring entry is classified as a "Yurchenko-style" vault in the Code of Points. Many variations of the original vault have been introduced by gymnasts in international competitions. Even as of 2006, gymnasts and coaches continue to develop more difficult versions of the Yurchenko.
Some of the most commonly performed Yurchenko-style vaults include:
Backhandspring entry:
- (Shushunova) 1½ twisting Yurchenko: Roundoff, back handspring entry; one and a half twisting layout. Abbreviated as 1.5Y.
- Double twisting Yurchenko: Roundoff, backhandspring entry; double twisting layout. Abbreviated as DTY.
- Amanar/Shewfelt (2½ twisting Yurchenko): Roundoff, back handspring entry; two and a half twisting layout.
Twisting entry:
- Luconi: Roundoff, back handspring with full turn entry; back tuck/pike/layout somersault
- Podkopayeva: Roundoff, back handspring with half turn entry; front pike somersault with 1/2 twist
- López: yurchenko 180° (Roundoff, back handspring with half turn entry)front layout somersault with 1/2 twist
- Khorkina: Roundoff, back handspring with half turn entry; front tuck somersault with 1½ twist
- Cheng Fei: Roundoff, back handspring with half turn entry; front straight somersault with 1½ twist


text:
Pool Financing
We understand how important it can be to obtain financing for your fiberglass swimming pool. Aloha has partnered with AMS Financial to offer you a potential financing solution. Below are some important questions and answers from our friends at AMS Financial to assist you.
Can I call in and just get a quote?
While we encourage any of our clients to call us with questions, our process is designed for a reason. Each individual borrower is unique in their financial situation. We strive to give each person the individual attention and customer service we are known for. Unfortunately, we cannot give quotes based solely on credit scores. We do not pull credit initially, and we want to provide each customer with a realistic rate, term, and max loan amount. We cannot do that without understanding our client's individual situation.
What is AMS Financial?
AMS has served over 5,000 home improvement dealer partners since 2004 and many thousands of consumers direct. We literally wrote the book on home improvement finance. AMS Financial has been featured as industry experts in Replacement Contractor Magazine 9/2011 and Aqua Magazine 6/2011, to name a few.
Why does AMS not pull credit initially?
AMS knows that in the current credit environment, most consumers monitor their own credit, so we do not pull credit initially. We ask you for your credit score. This, plus your liabilities, allows us to give you a realistic idea of what credit categories you fit into before having your credit pulled. Most loans are based off of other factors along with credit. We at AMS believe that a good loan officer understands underwriting and market conditions, and can provide our clients with a realistic idea of rate and payment initially without pulling credit based on the weight of the information provided. We give our clients a "free look", with no commitment. It prevents the client from being misled and allows them to make an informative decision based on facts.
What if I don't know my Credit Score?
That's OK too. You may use this link: GET YOUR FREE CREDIT SCORE HERE
Or go to one of the many credit reporting agencies available online. Having our clients know their own credit score prevents them from having numerous credit inquiries, which result in the score lowering. If our clients insist, we can pull credit.
What is the minimum credit score?
Our minimum credit score requirement is 580 for Mortgage, Secured, and Business / 640 Unsecure.
Does AMS pull Credit?
Once we present the borrower with a scenario and the borrower agrees to our release, credit will be pulled. Our estimates are based on the score and information the borrower provides. AMS has an extremely high closing ratio.
Why does AMS have so many products?
AMS understands that each borrower has different circumstances; by offering different products, we have the ability to find the right product available for him or her.
What happens when we send in our initial application?
Once we receive the initial application, our team goes to work. We look at every aspect of the borrower from a financial standpoint. We take into account if the borrower has the ability to refinance their home, obtain a secured loan, or pull money out of an existing business. We do this in 24 hours and provide our clients with all of the options available. We give them the information they need to make the right decision.
If I decide I like the product what then?
At that point, when you return the paperwork, we begin the full application process, which will result in a credit pull. We then request supporting documentation such as ID, pay stubs, and tax returns.
Is there an Application Fee?
What else can AMS do for me?
If you have recently done business with AMS and have obtained an unsecured loan with us for your project,
AMS will assist you, at no added fee from us, in the refinance of your home.
Click HERE to fill out an application
Questions? Please give Aloha a call at (800) 786-2318.


text:
|12 Apr 2011
BSOD dmp files without logging in.
Ok so I read the sticky and I know the instructions for posting about BSOD crashes. Sorry if I am violating strict rules but I need some help. The BSOD screen is preventing me from logging in. It actually appears as windows tries to log on. I also tried safemode and that was a no go. So I can't access the desktop in the usual way in order to post the files you guys need to help me.
This is my friends CPU. It is a Dell laptop studio 1745 with windows 7 home premium on it. Right now I am running the diagnostic utility that comes with it and it is checkin the harddisk for errors as well as the memory for errors. It should come up clean as I am pretty sure this is a driver issue. The BSOD error is: "irql not equal or less" and I have lurked on this forum enough to know you guys can really help identify it.
He does not have a recovery disk, but I do have a pendrive Linux bootable drive. It is running ubuntu 10.10 and I can access his files in that round about way. Is there a way I can get these dmp files you guys need with the pendrive bootble? Is there any way to do it without accessing the desktop?
At this point I am ready just to boot up Linux, recover any data he needs, and whipe the entire dive back to default. But I want to know if I have other options. Thanks for your time.
|My System Specs
|12 Apr 2011
windows 7 ultimate
There's a rootkit that's been doing the rounds since December that shows itself through blue screens with a IRQ not less or equal stop code. It usually blames the iastor.sys driver as the cause.
It starts by blue screening/freezing on random programs, then when booting to Normal Mode, then when you try to boot to Safe Mode. Eventually it will allow no access whatsoever.
Download TDSSKiller and run it in Safe Mode to rule out the RootKit.
Persevere trying to get into Safe Mode as it may well slip up and actually let you in. Once the TDSSKiller is set up, you need at most a 30 second window to run it. You may well be able to run it through your Linux, I'm not 100% with that.
|My System Specs
|12 Apr 2011
It is still running the onboard memtest... I will download that utility using the linux bootable and place it on the desktop. The only problem is, as you said, it is highly unlikely that I can make it to the desktop in safemode before the BSOD kicks in. I will try that first, and I will look up if there is anyway to run that program off the pendrive instead. Will post back with results.... Though I am open to anymore advice since I am doubtful I can access the desktop and doubtful that Linux can run the program. However there is a program in Linux called WINE that should allow me to run windows exe's ... I'll see if that works. I will check back in as soon as the memtest finishes. Thanks in advanced
|My System Specs
|12 Apr 2011
Ok so the memory and haddrive checked out fine. Which means this really is a software issue. I booted Linux and put the exe on the desktop, but Linux does not execute the file, nor is the file compatible with WINE... So I tried to boot up in safe mode again... And the BSOD's got worse, now it comes up even before I can type in the password to log in when in safemode.
Any ideas?
|My System Specs
|Thread Tools
|Similar help and support threads
BSOD right after Logging In
Entered my password and went to grab a coffee. Saw BSOD screen upon returning. I have returned to an image from 10 days ago the other day due to an unrelated issue. Event Viewer is clean (error 16 from Adobe Reader, my usual Paragon and ZoneAlarm warnings and occasional ide error which I...
|BSOD Help and Support
system hangs after logging off and logging back!
hi! I logged off and logged back in.My system displays a black screen and doesn't log back in.It freezes and doesn't log back in. Help would be appreciated. mahesh
|Performance & Maintenance
BSOD while logging in
Hi, I just installed Windows 7 Profesionnal 32 bits and I had the "Missing boot mgr". I managed to fix it but when I enter my password, it says welcome but spins around then I see a quick bsod before the computer restarts.
|BSOD Help and Support
Logging bat files, how?
Hey guys I want to log the outcome/what happens when I run a .bat file in startup. How do I do it? Am not interested in pausing it, just create a log file. // Chris
|General Discussion
When logging in to windows 7 all my files are missing
Please help me!!! I have installed windows 7 32 bit and yesterday everything was fine i set all my shortcuts to the tab and copied all my files from my external hardrive. I set up my email account and installed a few programs aswel and everything seemed perfect but when i logged on this morning all...
|General Discussion
|Our Sites
|Site Links
|About Us
|Find Us
Windows 7 Forums is an independent web site and has not been authorized, sponsored, or otherwise approved by Microsoft Corporation. "Windows 7" and related materials are trademarks of Microsoft Corp.
© Designer Media Ltd
All times are GMT -5. The time now is 14:18.


text:
Original Max Payne Going Mobile
Rockstar Games has announced that Max Payne will come out in HD for mobile devices this fall. Available for the first time on mobile, Max Payne will have connectivity to the Rockstar Games Social Club and boast the same features as its PC counterparts — including HD graphics and high-resolution textures, taking full advantage of the latest mobile technologies, including incredibly customizable controls.
The original Max Payne was released over 10 years ago, and its stylish presentation broke new ground in video games. Max's immersive story made him one of the genre's first multi-dimensional characters, attracting loyal fans worldwide. For folks who aren't familiar with the tortured anti-hero this should be a good introduction before Max make his long awaited return in iconic in Max Payne 3 come March 2012.


text:
From CBG
Why isn't it working?
Wiki is very slow and Biblio extension does not work
- OK, the problem is that PubMed allows only one query per second, and we are adding a lot of PubMed references at the moment. Things should stabilize with time. Now the extension is on again. Thu Feb 5 15:09:05 CET 2009
- The Biblio extension has problems with downloading data from PubMed. I disabled it temporarily, hopefully it will be back soon. Thu Feb 5 14:56:23 CET 2009


text:
Courtesy of Hirshel Tzig
To the Hebraically challenged: the above is a greeting in a charity brochure. Since charity receptions and the occasional dinner are the best we have for going out in the evening, for men that is, the charity brochure is the equivalent of the society pages in Tatler. Not unfortunately who's going out with whom as it happens so quickly round here that you've barely kissed the mezuze to go out and it's time to come back in for the l'chaim announcing the engagement.
Besides being the only distraction from drawn-out speeches by speakers internationally renown from their lectern-thumping histrionics, the brochure is also an indicator of who's going places. 'He? Last year he had a silver page and this year a diamond! Not bad. What's he into?' And 'Where's he, didn't he have a platinum last year? Nebech, men hot im baganvet. I hear his wife's started a playgroup.'
It is customary in such instances for pages to be donated for the elevation of dead souls. Or rather the souls of dead bodies since we're generally dualists in matters of body and soul. So if while you're alive they'll smite your body to benefit your soul, when you're dead they'll feed on others for the same purpose. As Bob Dylan might not have said, 'they'll stone you when your trying to earn some bread/they'll stone you when you're try'na be so dead. Everybody must get fleeced' Besides, you cannot really write 'In Loving Memory' as we don't do love plus it'll make you sound like a United Synagogue member. What next, gravestones in English?
For similar reasons while your wife can join you at the bottom of the page as 'Joe Blogsovitch and his missus', first names are verboten. Females round here generally get first names for 3 reasons: for use in supplications when their child is ill (or if they've committed a misdemeanour, when they're older), for matrimony and for when they're dead. Other than that they might as well be numbered since you don't really need a first name to cook supper or give birth even a dozen times.
The page above is from just such a brochure taken out by one of the great and good of the community whose wife is a scion of an even greater and better family, especially if these things are calculated by bank balances. The souls being elevated are of a man and woman both whose names are given in full. But instead of the greeting, or whatever you call such elevations, ending with 'X and his companion', 'companion' or 'pair' being acceptable Hebrew metaphors for one's better half, some copy writer with a sense of mischief substituted 'companion' with 'and his maid'.
'Not nice' I hear you say and it is indeed despicable considering his status and esteem. One doesn't as a rule announce one's maid in a charity brochure. But on the other hand it's still preferable to spelling out her name in full since that could have aroused lascivious thoughts in readers even while being excoriated in sermons for just such thoughts. As the Talmud tells us, 'Where there is a desecration of God's Name, honour is not afforded even to the great.'


text:
KBC GBJJ Questions – Ghar Baitho Jeeto Jackpot – KBC Game Show KBC Question 3rd November 2017 for JIO User KBC GBJJ Today's Registration Question:
KBC GBJJ Questions
SONY TV is asking KBC Registration Question to complete the registration process for KBC Season 9. Lots of people from India are answering a question which has been asked in last two days. We all know that India is one largest country with approx 125 crore populations. Due to this, there might be many people are still not getting a chance to participate in a Registration process. For such people, SONY TV is going to ask KBC GBJJ Questions today on 3rd November 2017 at 09:00 PM. Importent hurdles here is, Only Reliance JIO user are allowed to participate in this KBC Registration 2017.
Check Today's : KBC GBJJ Question 2017 Answer
GBJJ Question for Today (3.11.2017) will be update shortly. Check our KBC 2017 Latest News category tab to read all latest news..!
KBC Today Question Answer
Unregistered candidates must submit their answer of KBC Today Question (03 Nov 2017) to complete registration. There are several way likes Website, SMS, Call, and Mobile App to participate in this process. Selected candidates through Audition will have a chance to play KBC Season 9 with most utmost actor Amitabh Bachchan.
KBC GBJJ Today's Question is Given Below….!
How to Win KBC Jackpot
KBC Registration Todays GBJJ Question
Last two KBC Registration Questions was quite easy to answer. Today it expects that KBC Forth Round Question will be easy to answer. This time it also expects KBC 3rd November Question will be related to politics. Cross your fingers & stay tuned with us to send answer for KBC 3 Nov 2017 Registration Question.
KBC JIO Registration Question 3rd November 2017
In the last article, we have described instruction to send an answer to your KBC Registration Question. Once again we would like to remind you same. So you will not make any mistake while sending your KBC Today's Answer.
KBC GBJJ Today's Question is Given Below….!
KBC Daily Quiz Jackpot
We have successfully provided answers of last two questions to our reader. Today we will also publish correct KBC 3rd November Question & Answer. So we request you to visit our website to find out correct answer of KBC Today Registration Question.
JIO Ghar Baithe Jeeto Jackpot Question and Answer


text:
Our Office Hours
Mon: 9:00a — 1:00p & 3:00p — 6:00p
Tues: 9:00a — 1:00p & 3:00p — 6:00p
Wed: 9:00a — 1:00p & 3:00p — 6:00p
Thurs: 9:00a — 1:00p & 3:00p — 6:00p
Fri: 9:00a — 12:00p (By Appointment Only)
Mechanicsville Virginia Chiropractor Dr. Tripp Stover
I came into Dr. Stover's office with sciatic pain and low back pain. I was taking inflammatory medicines until I came into his office. I feel 70% better and now I'm not taking the Advil any more. Dr. Stover takes time to explain what he's doing and how he's going to proceed with a plan. It is easy to get into see Dr.stover. It is fantastic to be walking and sleeping so much better.
READ MOREM. Miller
I was in an auto accident prior to coming in to Dr.Stover. I was experiencing low back and neck pain. I suffered for over a week before I went to a Doctor. I would say I'm 80% better by getting weekly adjustments. I can now lay on my side with out pain. I find I am sleeping much better also. I would recommend Dr. Stover to anyone suffering with back pain.
READ MOREV. Bloom


text:
Purple Flag is the national accreditation scheme for town centres at night. It is the "gold standard" for night time destinations. Like Blue Flag for beaches, places that meet the standards can fly the flag.
Norwich has been recognised as a beacon of excellence in how the city centre manages the evening and night time economy. Receiving a national accolade, Norwich has been awarded the prestigious Purple Flag status, which is a positive indication of an entertaining, diverse, safe and enjoyable night out in the city.
To secure the award, Norwich Business Improvement District (BID) worked with key partners; Norwich City Council, Norfolk Constabulary, licensed premises and other organisations to help tackle many of the effects of the city centres night-time economy on residents, businesses and visitors. Businesses that trade in the evening and night-time economy have established a 'Late Night Norwich' scheme. This important trade led initiative has created excellent working relationships across the leisure sector and has resulted in a significant impact on safety and wellbeing in the city.
The Evening and Nighttime Economy in Norwich is vibrant, diverse and welcoming – becoming a popular destination due to its extensive events programme. Within Norwich's Purple Flag area there are 347 licensed premises which add to the city's cultural scene. The variety and number of venues and events range from live music and festivals at large venues such as The Open, to literary readings and artwork showcases based in some of the city's more intimate locations.


text:
It looks like you're using an Ad Blocker.
Please white-list or disable AboveTopSecret.com in your ad-blocking tool.
Thank you.
Some features of ATS will be disabled while you continue to use an ad-blocker.
Not to offend but if this keeps up and ATSer are going to remain ignorant of the facts of this image, we are going to be pushed back to the caveman in understanding reality. There is probably not going to be many FANS for this, But I am saying it now, WAKE UP ATSers.
Originally posted by thetiler
Originally posted by blackmetalmist
Originally posted by spiritualarchitect
It looks like some kind of alien machine. Made by beings that have no idea of symmetry.
How would you explain the image in this photo?
Beings that have no idea of symmetry ? You would think being advance as they are they would know and understand the concept of symmetry. Looks like rock formation to me.
Not to offend but if this keeps up and ATSer are going to remain ignorant of the facts of this image, we are going to be pushed back to the caveman in understanding reality. There is probably not going to be many FANS for this, But I am saying it now, WAKE UP ATSers.
That bio sprayer is NOT ROCKS, you say lake of symmetry You guys are not getting it at all. Your missing the boat. There IS an alien civilization up on mars, they seem to be living underground. They utilize biological material to THEIR advantage. That is why things look so nature like.
Just like what was posted about the TUBES a week ago at ATS, they don't quite look symmetrical.
When oh when are WE going to wake up and listen to what NASA is trying to SHOW US?
Of course they are going to deny ! Until the build up is to their liking, only they know that.
Many of the tubes are around structures, there was a post about it here at ATS a week ago. naive posters say nature when you have the tubes that are 7/8th in the ground with the ribs partly showing, the MISTAKE that the rockers and the nature -ribbers make is that they think are just natural and not guided by a high intelligence HELLO, it doesn't take a nasa scientist to realize that nature just doesn't BEND around structures. IT WAS PLANNED and nasa KNOWS IT BIG-TIME ! Of course they are going to deny until the right time.
The brooking institute report, they take seriously. especially a civilization that could be 1000's of years ahead of us
YOU THINK IT IS STUPID TO HAVE NATURE DO THEIR DIRTY WORK? Tubes - bio sprayer? HELLO!
Check out the Golden Gate Bridge and how much anybody would have to pay each day to drive over it! $6.00 a day, and a lot of that is for upkeep !
My Theory"
Ernest Norman - Mental telepathy expert
Book - The Truth About Mars"
A martian -Nur El stated the tubes are transportation tubes.
Lonnie Zamora - 1964 April 24, I say are martians checking out our planet (every 2 years when earth is closest to mars!
They CAN cloak there craft. Check out Linda Mouton's interview with a prison guard when he was waiting for a prisoner to be released ! Incredible interview!
Gary Wilcox April 24th 1964, talked with two martians when they (martians) landed on his farm in NY. The craft was OVAL like Lonnie's sighting and the beings were small with space suites from head to toe just like Lonnie's sighting. THEY SAID THEY WERE FROM MARS! I say they are the same beings and craft that Lonnie saw.
Donald Shrum Book "Aliens In The Forest. 1964. I say are from mars because they looked identical to Lonnie's discription (smaller in size).
As a kicker look at this Robot Head and notice how it looks so similar to Donald Shrum's robots that tried to get him off the tree.
images.google.com... .220.127.116.11.184.108.40.206126.96.36.199...0.0...1ac.1.2.img.Inzzp1olh8Q#imgrc=q3m3uLJn9DBblM%3A%3Bw-JSVOJyOR1L2M%3Bhttp%253A%252F%252Fmembers.tripod.com%252Fimz adiradenoy%252FDatasHead.jpg%3Bhttp%253A%252F%252Fimzadiradenoy.tripod.com%252Fpage8.html%3B478%3B503edit on 12-2-2013 by thetiler because: spelling and grammar and thought
Originally posted by spiritualarchitect
If this is true, WHAT are the censors hiding if not more technology?
Originally posted by spiritualarchitect
Earth has been visited for decades, so why limit yourself to a hotel in space.
Why not build hotels on the Moon and Mars.
And if you do not want to be seen, put your hotel underground and camouflage your monorail system to look like sand dunes.
Originally posted by spiritualarchitect
If this is true, WHAT are the censors hiding if not more technology?
Originally posted by spiritualarchitect
I see no one has come up with an explanation of what the photo shows, except the lame excuse "rocks".
Originally posted by spiritualarchitect
I see no one has come up with an explanation of what the photo shows, except the lame excuse "rocks".
If they delete the original MOC image they raise a huge red flag admitting there was something there to delete.
As for Google Mars, can you can see the area on there that the video claimed was censored in 2010?
How much larger in area is it than the MOC photo... maybe acres... maybe miles?
Of course we would need to see the correct location marked on it for soemone to verify.
Originally posted by spiritualarchitect
reply to post by BigfootNZ
I have already stated what the unnatural explanation could be.
I am looking for a natural explanation to explain away an unnatural one.
Rocks that look like a pipe shooting out liquid?
That to me is a laughable excuse.
An easy out avoiding something they do not want to think about.
Originally posted by BigfootNZ
So in that regard... yes, its a large tube recessed into martian mountain side piping fluid from the nearby underground buildings and expelling it out onto the surface for some unknown reason.


text:
|Project by LightfootLtd
|posted 06-15-2012 03:21 PM
|4349 views
|16 times favorited
|9 comments
Anchor-Beam Table: This piece features a pedestal base built to resemble the magnificent anchor-beams found in the early Dutch barns of Pennsylvania. Designed to withstand the significant spreading forces placed on them by the enormous roof, the fully housed mortise and tenon combine time tested functionality with the elegance of true all wood joinery. Built from Local beetle kill pine, this base is stained in a dark walnut to bring out the grain, and to provide contrast to the thick cherry top. Natural Watco Danish Oil was applied to the surface of the top in order to bring out its rich color and to give depth to its texture. This was followed by several coats of a clear hard wax to prevent water staining.
-- LightfootLtd.Wordpress.com www.facebook.com/LightfootLtd
9 comments so far
#1 posted 06-15-2012 03:28 PM
You should post some close ups of the m&t joints. Looks very well done.
-- Nature created it, I just assemble it.
#2 posted 06-15-2012 04:35 PM
-- "Man's ingenuity has outrun his intelligence" (Joseph Wood Krutch)
#3 posted 06-15-2012 06:30 PM
Damn that's a nice table. Well-balanced design and excellent craftsmanship. I love it.
#4 posted 06-15-2012 06:34 PM
Very nice! Being new to woodworking but having inherited quite a bit of tools, I am interested in doing a similar table. I am wondering about expansion, how do you account for it when doing a picture frame border/perimeter as shown?
-- Brian
#5 posted 06-15-2012 11:05 PM
Fantastic looking table! Can tell just from the pics I can tell it'll stand the test of time!
-- Ben from IL
#6 posted 06-15-2012 11:54 PM
Beautiful. I particularly like the pedestal style. Very well done!
-- Rick, Tennessee, John 3:16
#7 posted 06-16-2012 09:53 AM
Thats one nice table.
-- arnies
#8 posted 06-16-2012 11:15 AM
Really like the style and design. Am I right in thinking the pegs had to be installed before one of the stiles were attached?
-- ***Pat*** Rookie woodworker looking for an education!!!
#9 posted 06-16-2012 11:45 AM
Great looking table, really nice work.
-- "I am a firm believer in the people. If given the truth, they can be depended upon to meet any national crisis. The point is to bring them the real facts." - Abraham Lincoln
Have your say...
You must be signed in to post the comments.


text:
Czech court to hold public hearing on challenges to EU reform treaty
[JURIST] The Constitutional Court of the Czech Republic [official website, in Czech] announced Tuesday that it will hold a public hearing on October 27 regarding a challenge to the country's signing of the European Union (EU) reform treaty, known as the Treaty of Lisbon [EU materials; JURIST news archive]. The court will hear arguments [Ceske report] against the treaty from various government representatives, including President Vaclav Klaus [official website, in Czech]. In addition, a group of 17 Czech senators announced on Tuesday that their legal challenge [Xinhua report] will involve whether the treaty violates the Constitution of the Czech Republic [text]. As the last remaining country to ratify the treaty, the Czech Republic is receiving pressure from the remainder of the European Union. EU Commission chief Jose Manuel Barroso [official website] urged [press release] the Czech Republic to sign the treaty and not raise artificial objections, saying it would be "completely absurd" to reopen the ratification process in the other member states.
Efforts to ratify [JURIST news archive] the treaty in all of the 27 member countries required for approval have met some obstacles. The treaty was finally approved by Poland and Ireland [JURIST reports] earlier in the month, after certain guarantees were made by the EU. Germany signed [JURIST report] the treaty last month. In March, the Senate of the Parliament of the Czech Republic [official website] voted to approve [JURIST report] the treaty, but Klaus refused to ratify the document. The Czech Republic's Chamber of Deputies [official website] approved [JURIST report] the treaty in February.


text: Beginning as the home to the Aireal Alchemy project, Skyhigh Odditorium has blossomed to become an active center for alternative fitness & performance art in West Oakland. Offering weekly classes in aerial silks, handstands, pole, dance, and conditioning exercise, the Odditorium is staffed by eccentric and passionate circus professionals. The Odditorium features shared and private kinetic, multimedia, crafting, and holistic workspaces, managed by Bay Area field professionals.


text:
Whether you're camping in the great outdoors, taking a scenic road trip, or simply picnicking in the park, keeping fresh food properly chilled at a food-safe temperature is always a challenge when you're miles away from the nearest fridge. Here are smart tips for packing a cooler or ice chest so food stays cold longer and nothing gets soggy or crushed.
How to Pack a Cooler
Top Tips
• Chill all food and drinks before packing them.
• Seal food in waterproof containers to keep it dry and uncrushed.
• Keep the cooler as full as possible.
• If you can, have a separate cooler for drinks so the cooler doesn't lose its cool every time someone opens it to get a drink.
• Keep the cooler in the shadiest spot you can find.
• Don't drain melted ice water -- it actually helps keep food cool longer. It's true!
For You Gearheads
The 10 Best New Camping Splurges
The Best New Ultralight Luxuries for Backpacking
Tips for Camp Cooking
5 Strategies for Easy Camp Cooking
3 Tips for Way Better Backcountry Cooking
Stroll through our collection of top-rated camping recipes, including 7 camping snacks that won't destroy your tent


text:
The socialite wife of the Fisher Island Club CEO spent Christmas in jail after stealing a $5,000 sweater from a Madison Avenue shop, according to a report by nypost.com.
Stefanie Lackner, 46, was caught last year leaving a dressing room at Bruno Cucinelli with a sweater in a shopping bag, according to court papers. She was sentenced to a month behind bars and began serving her sentence last week.
Lackner's husband is Fisher Island Club chief Bernard Lackner, who took over the post last year after serving as general manager of New York's Hotel Plaza-Athénée.
Stefanie Lackner is serving her time on Rikers Island, according to the report.
Her usual home is in a Southampton mansion.


text:
Claiborne County, Tennessee's March
1997 Quieries
Donald Locke Mon Mar 31 19:11:25 1997
I am researching LOCKE , LOCK families that went to Claiborne county and Jefferson county Tn from Ky Washington Henry LOCKE and wife Mary PRITCHARD went to Jefferson county in the early 1800's , had at least 1 child born in Jefferson county , John Henry Locke b. 1826 William Locke b. 1808 Ky married Sarah Carroll or Carol in 1844 in Claiborne county Tn I am looking to fill in some of the gaps :) For Locke family Genealogy come look at my web page ! http://members.aol.com/LOCKEroots/ It has several Locke web pages linked in it ! and more :)
Ronda Houston Mon Mar 31 21:46:16 1997
Searching for the following families: WILBURN and SEALS. William Wilburn
married Minerva Seals in 31 Dec 1843 in Claiborne Co, TN. Who were their
parents? Will share info.
Would appreciate any scrap of information on the NEWPORT family, any of them, who lived in Caliborne or Union Counties in the late 1700's or early 1800's. Need help. Thanks in advance.
Edna Clack Wed Mar 26 15:04:49 1997
Would someone with access to Claiborne Co marriage records please look to see if there was a marriage of Elizabeth NEWPORT to _______ James prior to 1835. Thank you in advance, this will help me tremendously.
Brad Dyer Mon Mar 24 21:35:34 1997
I am searching for the parents of John MYERS, b. 182-, of Claiborne County. He married Arminda CARPENTER on 10/19/1843. Any help concerning this John MYERS would be greatly appreciated.
Bev Traxler Mon Mar 24 13:45:58 1997
BROGAN OF UNION COUNTY. Maynard BROGAN born November 1859, married Mary Malinda ROUSE born June, 1863. Maynard had a brother Allen BROGAN who was Mary Malinda's first husband. Anyone out there with BROGAN information please contact me. Thanks in advance!
Joyce Scott Sharpe Sun Mar 23 19:18:36 1997
Scott Family - looking for records regarding those buried in what is known as the Scott Family Cemetery in Shawanee, TN or any other family history records that may be available for this area. My father was Oakley Andrew Scott b 12-08-1919, d 08-1977, grandftr James Parker Scott b 11-20-1887, d 10-22-1938, md to Pearl McVay b 05-29-1879, d 07-11-1949, ggrndftr William Parker Scott b 04-03-1848, d 08-08-1890, md Virginia Ann Mcpherson 08-27-1875, gggrndftr Hampden S. (could be Seymour) Scott b abt 1800, d abt feb 1885, md Rebecca Kermer (Kemmer) 03-03-1828, ggggrndftr Edward Scott md Sallie Corde, furthr info indicates an Joseph Scott, (That's all she wrote)
Sandy Pressler Tue Mar 18 08:49:07 1997
Am researching and would like info on the following names: surname MOORE - Ephraim ("Eph") (his mother was called Ellie), Louetta (used to work at hospital in Middlesboro), Bobby Ruth, Walter (would be around 60-70), E.J. surname SMITH - Harrison ( sons- Andrew, Robert Newton, William Sherman; daughter-Loucindy) surname COLLINS - Wiley; "Granny" (mother in law of Harrison; grandmother of Ephraim Moore; not sure what maiden name is second marriage was to a "darkskin" ??; died in Harlan Co, KY at age 101 in late 1930's) surname SWEAT or SWEET - possibly Becky??
Eugene Cloud Wed Mar 19 11:44:46 1997</strong>
Looking for information on Green Berry Cloud [b.1795] and married to Barthena Cox. His son [I believe] was Benjamin Frank Cloud [b.1825] married [1850] to Nancy Middleton [b. 1827]. Frank and Nancy Cloud were my ggrandparents.
Eddie Mills Dugger Tue Mar 18 22:19:03 1997
Seek information re: JOHN HORTON MILLS, born in Tennessee, we are reasonably sure it was Claiborne County, Tennessee. His father's name was Riley Mills, need to find out who his mother was, any siblings, etc. He was born February 14,1861. If anyone knows anything about him or his family, please let me hear frim you. Thanks.
Carolyn Singleton Miller Wed Mar 19 15:30:25 1997
Searching for information on Charlotte (Lotte) Carpenter, married Jeremiah Singleton Clinch River area, Claiborne Co. 11/30/1838. I need to find the family of both Charlotte and Jeremiah if possible. Any clue would be helpful, Thanks.
Norman Davis Mon Mar 17 23:43:11 1997
Would like to know if there was any MILLS in Claiborne County, Tennessee between 1840 and 1860. Looking for a Riley Mills that may have left Claiborne County after 1861 and went to Stone County, Missouri.
James Hixson Mon Mar 17 05:41:48 1997
I am looking for information concerning FRANCIS J. SMITH, JOHN WELCH, PEYTON F. SMITH, AND NANCY WELCH SMITH who came to Claiborne Co, TN. in 1828 fron Va and eventually moved to Hamilton Co., TN. Any help would be greatly appreciated.
Carolyn Singleton Miller Sat Mar 15 13:09:57 1997
Looking for JEREMIAH SINGLETON born 1775 shown on the 1840 Claiborne Co. Census,and his wife MORNING CUMBER ? born 1782. Circa 1800-1820 Grainger Co. Tenn. and son Richard Singleton. Who were Jeremiah's or Mornings' parents ? Does Richard have any siblings ? Any information on this family would be appreciated.
Jim Birch Sun Mar 16 13:31:54 1997
Interested in exchanging informatin with anyone related to Charles BIRCH born 1839 in England. Settled in Glenmary, Scott County in 1889. Later lived in Wooldridge, Campbell County, Eagen, Campbell County, and Pruden, Claiborn County. Some family went to Cincinnati, Ohio in 1915.
Elaine Sexton Sun Mar 16 13:35:10 1997
Nathaniel Wilson [1797-]married Rachel Davis [179901873] Ch: James, Joseph, Margaret m. Tramel, John m Louisa Hurley, Martha m Joe Roiston, Mitchell m Martha Davis. Believe Nathaniel's mother was Margaret, looking for information on Nathaniel and Rachel's family. Nathaniel's silbings Thomas, James, John, Jerry, Mitchell, and Richard. Family lived in Clairborne County 1830.
Pete/Mohawk97-03-19 21:43:31 EST
Beverly Traxler:97-03-19 20:28:41 EST
I believe I can be of some help to anyone researching the " Martin Luther Miller, born 1758, died 1838" lines. I have quite a bit of information to share, if someone needs it. Would love to be of help to someone. Thanks, Bev Traxler in Michigan.
Sandy Pressler Sat Mar 15 07:25:20 1997
Searching for the following -SMITH (Harrison, Andrew, Robert Newton, William Sherman); Granny COLLINS (lived in log cabin, lived to be 101; had second marriage to "a darkskin") and Ephraim ("Eph") MOORE
GREGG BURKS Sat Mar 15 11:29:07 1997
Trying to find the parents of DICY HIGHTOWER LYONS LIKE. b. ca 1814, place unknown, she married SAMUEL LYONS ON Jul. 5, 1832, in Knox County. She remarried on Sept. 1, 1845, in Knox County, to MICHAEL LIKE. They eventually moved to Claiborne County. Believe her parents were EPHARODITUS AND NANCY CLAY HIGHTOWER of Grainger County, but can not prove it. Would appreciate any help on finding who her parents were.
Lee Dearmin Fri Mar 14 11:51:46 1997
BUCHANAN, Isaac Stewart, b.ca. 1824 Washington Co. VA, d.4/28/1862 probably in Claiborne Co. TN. Buried in the Buchanan family cemetary near Tazewell. He was a physician who came to Claiborne Co. in the 1845-1855 timeframe from Washington Co. VA. Would be interested in any information including obituary, wills, doctor notes or announcements, etc. including information on his children which included: George W. Buchanan b. 1848, Thomas J. Buchanan b. 1850, James Madison Buchanan b.April 20, 1852, William R. Buchanan b.January 18, 1854, Peter R. Buchanan b. ca. 1857, Laura V. Buchanan b. 1859, John Franklin Buchanan b. December 01, 1861.
James S. Rice Fri Mar 14 13:07:17 1997
RICE Looking for descendents of THOMAS BEN RICE, who lived in Claiborne Co. Would like to know who other members of the family were.
Gloria Knuckles Compton Thu Mar 6 17:17:29 1997
BLACK FAMILY - Alexander and Isabella Martin Black came through Tenn. around 1800. Looking for anyone with family connections. KNUCKLES FAMILY - William R. Knuckles came from Claiborne Co. from all reports. Looking for any relatives of the KNUCKLES family. He may have lived there between 1820 - 1840.He moved from Tenn. to Bell Co., Ky.
Willis A. Hickey Wed Mar 5 10:28:54 1997
I need info on my great grandfather Pleas Hickey, married Sofia____. Known children; Grover C.,John,Julia, and Cynthia. Lived in Eagan, Tn early 1900s, moved to Harlan Coiunty< KY around 1920. Pleas Hickey was circuit riding preacher. I would like any info as to where he lived and died and the maiden name of his wife Sofia.
Carole Wed Mar 5 09:24:17
Pam Glancy Tue
Mar 4 10:29:43 1997
Richard E. Wallis Tue Mar 4 04:27:51
This site is part of the TNGenWeb project


text:
|ognizant Communication Corporation
The Regenerative Medicine Journal
Cell Transplantation, Vol. 15, pp. 213-223, 2006
0963-6897/06 $90.00 + 00
Copyright © 2006 Cognizant Comm. Corp.
Printed in the USA. All rights reserved.
Timing of Cord Blood Treatment After Experimental Stroke Determines Therapeutic Efficacy
Jennifer D. Newcomb,1,2 Craig T. Ajmo, Jr.,3 Cyndy D. Sanberg,4 Paul R. Sanberg,1,2,3,4 Keith R. Pennypacker,3 and Alison E. Willing1,2,3
1Center of Excellence for Aging and Brain Repair, University
of South Florida College of Medicine, Tampa, FL 33612, USA
2Department of Neurosurgery, University of South Florida College of Medicine, Tampa, FL 33612, USA
3Department of Pharmacology and Molecular Therapeutics, University of South Florida College of Medicine, Tampa, FL 33612, USA
4Saneron CCEL Therapeutics, Inc., Tampa, FL 33612, USA
Embolic stroke is thought to cause irreparable damage in the brain immediately adjacent to the region of reduced blood perfusion. Therefore, much of the current research focuses on treatments such as anti-inflammatory, neuroprotective, and cell replacement strategies to minimize behavioral and physiological consequences. In the present study, intravenous delivery of human umbilical cord blood cells (HUCBC) 48 h after a middle cerebral artery occlusion (MCAo) in a rat resulted in both behavioral and physiological recovery. Nissl and TUNEL staining demonstrated that many of the neurons in the core were rescued, indicating that while both necrotic and apoptotic cell death occur in ischemia, it is clear that apoptosis plays a larger role than first anticipated. Further, immunohistochemical and histochemical analysis showed a diminished and/or lack of granulocyte and monocyte infiltration and astrocytic and microglial activation in the parenchyma in animals treated with HUCBC 48h poststroke. Successful treatment at this time point should offer encouragement to clinicians that a therapy with a broader window of efficacy may soon be available to treat stroke.
Key words: Human umbilical cord blood; Middle cerebral artery occlusion (MCAo); Inflammation; Infarct core; Therapeutic window
Address correspondence to Alison E. Willing, Department of Neurosurgery, University of South Florida, 12901 Bruce B. Downs Blvd., MDC78, Tampa, FL 33612, USA. Tel: 813-974-7812; Fax: 813-974-3078; E-mail: firstname.lastname@example.com
Genetically Engineered Human Mesenchymal Stem Cells Produce Met-Enkephalin at Augmented Higher Levels In Vitro
Ikuko Sugaya,1 Tingyu Qu,2 Kiminobu Sugaya,1 and George D. Pappas2
1Biomolecular Science Center, Burnett College of Biomedical
Sciences, University of Central Florida, Orlando, FL 32816-2364, USA
2The Psychiatric Institute, Department of Psychiatry, and Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA
We have reported that transplantation of adrenal medullary chromaffin cells that release endogenous opioid peptides into pain modulatory regions in the CNS produce significant antinociceptive effects in patients with terminal cancer pain. However, the usefulness of this procedure is minimal because the availability of human adrenal tissue is very limited. Alternative xenogeneic materials, such as porcine and bovine adrenal chromaffin cells present problems of immune rejection and possible pathogenic contamination. In an attempt to develop opioid peptide-producing cells of autologous origin, we have transfected human mesenchymal stem cells (hMeSCs) with a mammalian expression vector containing a fusion gene of green fluorescent protein (GFP) and human preproenkephalin (hPPE), a precursor protein for enkephalin opioid peptides. Enkephalins are major neurotransmitters that play an important role in analgesia by activating peripheral opioid receptors. Following the establishment of stable transfection of hMeSCs, the expressions of hPPE and GFP were confirmed and the production of methionine enkephalin (Met-enkephalin) was significantly increased compared to control naive hMeSCs (p < 0.05). Our in vitro data demonstrated that genetically engineered hMeSCs with transfected hPPE gene can constitutively produce opioid peptide Met-enkephalin at an augmented high level. hMeSCs are relatively easy to isolate from a patient's bone marrow aspirates and expand in culture by repeated passages. Autologous hMeSCs would not require immunosuppression when transplanted back into the same patient. Through targeted gene manipulation such as hPPE gene transfection, this may offer a virtually unlimited safe cell supply for the treatment of opioid-sensitive pain in humans.
Key words: Preproenkephalin; Gene transfection; Human mesenchymal stem cells; Autologous source; Enkephalins; Antinociception
Address correspondence to Dr. George D. Pappas, The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA. Tel: 1-312-413-4562; Fax: 1-312-413-4569; E-mail: email@example.com
Behavioral and Histological Characterization of Intrahippocampal Grafts of Human Bone Marrow-Derived Multipotent Progenitor Cells in Neonatal Rats With Hypoxic-Ischemic Injury
Takao Yasuhara,1 Noriyuki Matsukawa,1 Guolong Yu,1 Lin Xu,1 Robert W. Mays,2 Jim Kovach,2 Robert J. Deans,2 David C. Hess,1,3 James E. Carroll,1,3 and Cesar V. Borlongan1,3
1Department of Neurology, Medical College of Georgia, Augusta,
2Department of Regenerative Medicine, Athersys, Inc., Cleveland, OH 44115, USA
3Research & Affiliations Service Line, Augusta VAMC, GA 30912, USA
Children born with hypoxic-ischemic (HI) brain injury account for a significant number of live births wherein no clinical treatment is available. Limited clinical trials of stem cell therapy have been initiated in a number of neurological disorders, but the preclinical evidence of a cell-based therapy for neonatal HI injury remains in its infancy. One major postulated mechanism underlying therapeutic benefits of stem cell therapy involves stimulation of endogenous neurogenesis via transplantation of exogenous stem cells. To this end, transplantation has targeted neurogenic sites, such as the hippocampus, for brain protection and repair. The hippocampus has been shown to secrete growth factors, especially during the postnatal period, suggesting that this brain region presents as highly conducive microenvironment for cell survival. Based on its neurogenic and neurotrophic factor-secreting features, the hippocampus stands as an appealing target for stem cell therapy. Here, we investigated the efficacy of intrahippocampal transplantation of multipotent progenitor cells (MPCs), which are pluripotent progenitor cells with the ability to differentiate into a neuronal lineage. Seven-day-old Sprague-Dawley rats were initially subjected to unilateral HI injury, which involved permanent ligation of the right common carotid artery and subsequent exposure to hypoxic environment. At day 7 after HI injury, animals received stereotaxic hippocampal injections of vehicle or cryopreserved MPCs (thawed just prior to transplantation) derived either from Sprague-Dawley rats (syngeneic) or Fisher rats (allogeneic). All animals were treated with daily immunosuppression throughout the survival period. Behavioral tests were conducted on posttransplantation days 7 and 14 using the elevated body swing test and the rotarod to reveal general and coordinated motor functions. MPC transplanted animals exhibited reduced motor asymmetry and longer time spent on the rotarod than those that received the vehicle infusion. Both syngeneic and allogeneic MPC transplanted injured animals did not significantly differ in their behavioral improvements at both test periods. Immunohistochemical evaluations of graft survival after behavioral testing at day 14 posttransplantation revealed that syngeneic and allogeneic transplanted MPCs survived in the hippocampal region. These results demonstrate for the first time that transplantation of MPCs ameliorated motor deficits associated with HI injury. In view of comparable behavioral recovery produced by syngeneic and allogeneic MPC grafts, allogeneic transplantation poses as a feasible and efficacious cell replacement strategy with direct clinical application. An equally major finding is the observation lending support to the hippocampus as an excellent target brain region for stem cell therapy in treating HI injury.
Key words: Stem and progenitor cells; Syngeneic and allogeneic grafts; Motor behavior; Neurogenesis; Neurotrophic factor
Address correspondence to Cesar V. Borlongan, Ph.D., Department of Neurology, BI-3080, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912-3200, USA. Tel: 706-733-0188, Ext. 2485; Fax: 706-721-7619; E-mail: firstname.lastname@example.com
Progressive Dopamine Neuron Loss in Parkinson's Disease: The Multiple Hit Hypothesis
Paul M. Carvey,1,2 Ashok Punati,1 and Mary B. Newman1,2
1Department of Pharmacology, Rush University Medical Center,
Chicago, IL, USA
2Department of Neuroscience Program, Rush University Medical Center, Chicago, IL, USA
Animal models have been an essential tool for researchers and clinicians in their efforts to study and treat Parkinson's disease (PD). Thus, the various ways 6-hydroxydopamine is employed, the use of MPTP in rodents and nonhuman primates, the prenatal exposure to bacterial endotoxin, the postnatal exposure to environmental toxins such as paraquat and rotenone, the assessment of dopamine (DA) neurons in genetic knockout mouse, and even the behavioral analysis of fruit flies and worms have added significantly to our knowledge base of PD--or have they? Are these animal models manifesting a true model of PD? Have the 7786 published studies (to date) on PD with animal models led to a clearer understanding of its etiology, treatment, or progression? In this review we critically assess this question. We begin with a succinct history of the major contributions, which have led to the current animal models of PD. We then evaluate the primary issue of the progressive loss of DA neurons, which, except for a few studies, has not been addressed in animal models of PD, even though this is the major pathological characteristic of the disease. Lastly, we discuss the possibility that more than one risk factor for PD may be necessary to develop an animal model that shows synergy--the progressive loss of DA neurons. Thus, the multiple hit hypothesis of PD--that is, the effect of more than one risk factor--may be the start of new era in animal models of PD that is one step closer to mimicking the pathology of PD in humans.
Key words: Parkinson's disease; Dopamine neurons; Progression; Multiple hit hypothesis
Address correspondence to Paul M. Carvey, Ph.D., Chairman, Department of Pharmacology, Rush University Medical Center, Cohn Research Building, Suite 406, 1735 W. Harrison Street, Chicago, IL 60612, USA. Tel: 312-563-2563; Fax: 312-563-3552; E-mail: firstname.lastname@example.com
Neural Repair Strategies for Parkinson's Disease: Insights From Primate Models
Katherine Soderstrom,1 Jennifer O'Malley,2 Kathy Steece-Collier,2 and Jeffrey H. Kordower1
1Department of Neurological Science, Research Center for
Brain Repair, Rush University Medical Center, Chicago, IL 60612, USA
2Department of Neurology, University of Cincinnati, Cincinnati, OH 45267, USA
Nonhuman primate models of Parkinson's disease (PD) have been invaluable to our understanding of the human disease and in the advancement of novel therapies for its treatment. In this review, we attempt to give a brief overview of the animal models of PD currently used, with a more comprehensive focus on the advantages and disadvantages presented by their use in the nonhuman primate. In particular, discussion addresses the 6-hydroxydopamine (6-OHDA), 1-methyl-1,2,3,6-tetrahydopyridine (MPTP), rotenone, paraquat, and maneb parkinsonian models. Additionally, the role of primate PD models in the development of novel therapies, such as trophic factor delivery, grafting, and deep brain stimulation, are described. Finally, the contribution of primate PD models to our understanding of the etiology and pathology of human PD is discussed.
Key words: Parkinson's disease; Nonhuman primates; Animal models; Therapeutics
Address correspondence to Jeffrey H. Kordower, Ph.D., The Jean Schweppe-Armour Professor of Neurological Science, Director, Research Center for Brain Repair, Section Head, Neuroscience, 1735 West Harrison Street, Chicago, IL 60612, USA. Tel: (312) 563-3585; Fax: (312) 563-3571; E-mail: email@example.com
CNS Gene Therapy and a Nexus of Complexity: Systems and Biology at a Crossroads
Carolyn M. Tyler and Howard J. Federoff
Center for Aging and Developmental Biology, Aab Institute of Biomedical Sciences, Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester NY 14642, USA
Gene therapy is a potentially promising new treatment for neurodegenerative disorders such as Alzheimer's disease (AD), which has been difficult to treat with conventional therapeutics. Viral vector-mediated somatic gene therapy is a rapidly developing methodology for providing never before achieved capability to deliver specific genes to the CNS in a highly localized and controlled manner. With the advent and refinements of this technology one focus is directed to which genes are the most appropriate to select for specific disease indications. Nerve growth factor (NGF), a potent survival factor for critical cell populations that degenerate in AD, has been chosen already for clinical gene therapy trials in human AD patients. Much knowledge about the pathophysiological underpinnings of AD is still lacking to make clear which patients may benefit from a gene therapy approach. Moreover, a detailed understanding of sustained NGF action in the normal and diseased CNS needs to be resolved before conclusions can be drawn regarding the utility of NGF gene therapy. Systematic efforts to acquire this new knowledge should compel clinically and biologically sophisticated efforts to advance gene therapy for neurodegenerative diseases.
Key words: Gene therapy; CNS; Neurodegenerative diseases; Nerve growth factor
Address correspondence to Howard J. Federoff, M.D., Ph.D., Center
for Aging and Development Biology, Arthur Kornberg Medical Research Bldg.,
University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave.,
Box 645, Rochester, NY 14642, USA. Tel: 585-273-2190; Fax: 858-506-1957;
E-mail: email@example.com