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The Supreme Court listened to arguments a few weeks back concerning SB1070 Arizona's controversial immigration law in order to determine its constitutionality. This law, which has spawned countless copycat laws in other states and has resulted in lower courts challenging certain provisions, seems to be headed towards being upheld by the highest court in the land. At least this is the outcome one can infer from some of the Supreme Court questions and comments during the proceedings.
Coincidentally, Brewer was in Washington speaking at a flying monkey convention and, after showing her minions her newest tattoo (see below), she made her way to listen in on the SB1070 arguments.
After listening to some of the arguments and the seemingly favorable responses of the justices, Jan Brewer -- Arizona's Republican Governor, displaced alligator, and part-time crypt-keeper -- had an unexpected, embarrassing response to the scales of blind justice tilting in her favor. She became so sweaty and overtly aroused by the chance to continue peddling unfettered xenophobia, that she got the first recorded xenophobia-induced lady-boner. Yes. Apparently that is a thing.
A shot of Ms. Brewer's uncontrolled glee taken by a scared witness.
Ms. Brewer had to be escorted from the courtroom as she laughed maniacally and did nothing to conceal her excitement. In fact, when she finally found herself outside, she began thrusting her aforementioned enthusiasm aggressively in the direction of anyone of color who was unfortunate enough to be walking in her vicinity. She also reportedly began shouting - "I'll get you my pretties... and your little anchor babies, too."
Your handsome and humble servant-
El Guapo
El Guapo writes The Daily Refried, and is, without question, the foremost authority on all things sinvergüenza. Follow him on Facebook or Twitter @TheDailyRefried.
[photos by kiwanja, DonkeyHotey


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IHSE supports hospital in Bangladesh with converter
Oberteuringen, November 7, 2013 – IHSE GmbH, the worldwide leading developer and manufacturer of advanced KVM products for the switching, extension and conversion of computer signals, supports the "Gisela Hospital Project" in Bangladesh, by donating an urgently needed multi-signal converter.
Gisela Hospital provides basic healthcare for destitute and underprivileged people in a developing region in Bangladesh. Built by a local NGO with the support of a fund-raising project organized by German doctors, the hospital is now under local control. All medical equipment has been procured through financial and product donations. To reuse a legacy ophthalmologic diagnostic sonographic scanner in conjunction with a modern, space and weight-reduced flatscreen monitor, the hospital needed a solution for lossless conversion of high-resolution analog video signals to digital signals. IHSE's distributor BellEquip Germany together with Gisela Hospital's Association developed a solution in cooperation with IHSE to meet the complex requirements.
The multi-signal converter donated to Gisela Hospital by IHSE converts analog signals including S-Video and RGB to digital DVI signals. The converter supplies high investment security, extending the lifetime of legacy machines by enabling continuous use in conjunction with up-to-date monitors, which is also ecologically beneficial. Markus Drautz, Sales Director of IHSE said: "It was clear from the start that we wanted to support the project. If our converter enables an old medical instrument to be reused for charity purposes and perhaps even save lives, this really makes us proud."
About IHSE
IHSE is a leading developer and manufacturer of advanced KVM devices in global demand. KVM stands for Keyboard, Video, Mouse. KVM technology allows the switching, extension and conversion of these three primary computer signals and many else, e.g. DVI, HDMI, digital audio or USB. At their headquarters near Lake Constance, Germany, IHSE develops and manufactures switches for operating and switching between computers and consoles, as well as extenders for visually lossless signal transmission, with 30 years of experience.
IHSE products have been certificated for outstanding manufacturing quality, operability, resilience and enormous transfer speeds. Many renowned institutions across vertical sectors, including Broadcast, Post Production, Banking, Healthcare, Maritime, Air Traffic Control and Government rely on KVM solutions made by IHSE, Germany. For further information please refer to www.ihse.com.
Press Contact
Stefan Ruppert
IHSE GmbH
Maybachstrasse 11
88094 Oberteuringen
E-mail firstname.lastname@example.com
Phone +49 7546 9248-59
Fax +49 7546 9248-48
IHSE Press Release - IHSE supports hospital in Bangladesh with converter (252 KB)

subset: commoncrawl


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The Thermals' new album Personal Life is so accurately named you'll almost find it hilarious if you're a fan. It's a relationship-song LP, a million miles away from the political rants-and-riffs of debut More Parts Per Million and the spiritual rants-and-rage of The Body, The Blood, The Machine. But it still shows the same passion and energy, and tricky mindfulness, that has appealed to fans of the Portland trio since earlier in the decade.
Jumping from Sub Pop to Kill Rock Stars just when they've laid down polished-up sounding power pop tracks like "Never Listen To Me" and "Not Like Any Other Feeling" and especially full length closer "You Changed My Life" (#1 on the pop charts in a perfect world) may seem perverse, but there's no kink to loving their crisp new sound.
Hutch Harris and co. were smart enough to get Personal Life produced as professionally as possible, and yet the weird love-hate angst and surrender in the lyrics couldn't be a more unique juxtaposition. Live, I would expect the same immense blitzkrieg that band always brings out, no matter how less "sonic reducer" on the new album they may seem. And The Thermals did not disappoint.
The Thermals jumped into the set, with "I'm Gonna Change Your Life" the opener to the first side of the new album. The power pop crowd pleaser "I Don't Believe You," pummeled the audience with the high energy youthfulness The Thermals have always delivered over the years. "Never Listen to Me" was a toned down with Harris' rock version of singing low bringing your ears in closer for a proper listen.
Its raining outside, and within the intimate walls of the Music Lounge the trio's full sound envelopes you into somewhere cozy and away from the elements. With "A Passing Feeling" Harris' lyrical guitar licks accentuate his angst ridden vocals, and the tendons on Harris' neck become more prominent with every passing phrase.
"Only for You" rocked with Harris' surefire licks and the deep, penetrating bass from Foster, her bleached out ringlets bounced with a life force of their own as she headbanged and Westin Glass kept the beat. "You Changed My Life," a prologue of sorts to the performance opener, brings a youthful approach to jaded feelings, mixing a positive message with dysfunction. They completely blew me away when Harris jumps right into the closer, "Returning to the Fold," and I can't wait to catch their live act at The Broad Street Stage tonight at 9:15.


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Safe Haven Icons
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Produced on shared equipment that processes nuts.
• Sodium lauryl sulfate (SLS) or SLES
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Our Peppermint Foaming Hand Wash is free of these unnecessary ingredients. Natural Peppermint Oil provides its invigorating scent. The luxurious foaming action is due to Earth-friendly Coconut and Apple Amino Acids. Panthenol, Allantoin and Aloe combine to provide extra moisture and soothing properties.
• Environmentally low-impact formula hydrates, soothes and nourishes your skin as it thoroughly cleans without chemicals.
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• When should you wash your hands? According to the Centers for Disease Control, it's important to wash your hands:
– Before, during and after food preparation
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– Before and after caring for someone who's sick
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– After using the toilet
– After changing diapers or cleaning up a child who has used the toilet
– After blowing your nose, coughing or sneezing
– After touching an animal, animal feed or animal waste
– After touching garbage
• A study conducted by the American Society for Microbiology showed that overall only about 67% of people washed their hands after using the restroom. This means that about a third of the population does not!
www. abcnews.go.com/Health/story?id=117956&page=1#.UcMXJZVjDHg
• Try to avoid touching your face with your hands. Here's why: According to WebMD.com, about 80% of infectious diseases are transmitted by touch. When you unknowingly touch your face, the germs can enter through your eyes, nose and mouth. And those germs can also be transmitted to others through shaking hands (direct transmission) or handling items that others then touch (indirect transmission).
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Chapel Hill's Jenks Miller, aka Horseback, aims for the transcendent, dreamy, ecstatic, hypnotic, enveloping, life-affirming glow of classic New York minimalism, Düsseldorf krautrock and North Carolina math rock—but just happens to draw upon the icy spirit of black metal as his avenue. His second proper album, The Invisible Mountain, was released last year on Milwaukee's gloom-minded micro-indie, Utech, but its decidedly unique contents generated enough buzz to score a reissue (and a forthcoming future release) on the mighty Relapse Records, with a very sexy clear vinyl import available via Aurora Borealis.
It's apparent from the opening pummel of "Invokation" that, unlike cloud-gazer contemporaries Liturgy or Wolves In The Throne Room, Miller would rather be Rhys Chatham than La Monte Young, clamoring toward euphoria with more groove-centric white space than blackened blast 'n' blur. Throughout the record's psych-soaked first half, his slowly unfurling monster riffs embrace rock traditions more than they subvert them—mostly thanks to the sledgehammer-hard, Sabbath-meets-Tortoise drumming of Caltrop's John Crouch. But the pulseless 16-minute closer, "Hatecloud Dissolving Into Nothing," reinvents his more drone-minded heroes—Tony Conrad, Phill Niblock, Christian Fennesz—into a widescreen exorcism of backmasked strings, desolate acoustic strum, marrow-sucking growls and chiming church bells. This is essential, blood-soaked bliss.


text: This delightful little coin purse is excellent for keeping your money safe! It is also a perfect gift idea! You can make this one in less than an hour and there are less than 20 steps in putting it all together! What a great way to show off your favorite fabrics too! I made this one is made from cotton so when it gets a bit dirty just toss it in the laundry. (Cold water wash). All of my patterns are made with care and easy to follow to make it fun and there are lots of photos to help. This would be a great project if you are a beginner.... BASIC SKILLS NECESSARY Sewing SIZING / FINISHED MEASUREMENTS 3 1/2" X 3 1/2" square


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Lenovo Vibe K5 Plus (Dark Grey, 16 GB) (3 GB RAM)
If quick and seamless performance is what you are looking for, then that's what you get with the 64-bit Qualcomm Snapdragon 616 Octa-core processor. And when combined with the 3GB DDR3 RAM, games like Asphalt 8 and heavy apps like WhatsApp and Facebook will launch in a matter of seconds without any lag.
Listen to your playlist come alive or immerse yourself in your action-packed favourite movie as the twin high-performing speakers are optimized with Dolby Atmos technology. Don't just be a part, experience high-quality sound clarity wherever you go.
For the movie buffs, the readers and everyone else, the Vibe K5 Plus's 12.7-cm 1080p display is a visual treat. With a 178-degree wide viewing angle, you can enjoy watching your movies, YouTube videos, browsing in rich colour, tone and detailing.
You can optimize your viewing experience to a whole new level with the TheaterMax technology and this phone's Full HD display. Simply put on the ANTVR headset and you can dive deep into an immersive and life-life movie watching experience.
If performance is one USP, then beautiful craftsmanship is another. This sleek and compact smartphone is crafted with aviation grade aluminium alloy and weighs just about 142gs. The robust material ensures easy one-hand use as well as durability.
Powered by a removable rechargeable 2750mAh Lithium battery, this smartphone gives you more than enough juice to last the day. Watch movies, text people, browse the web and listen to the music without having to worry about running out of juice.
This smartphone comes with a 13MP primary camera and a 5MP secondary camera. Enjoy capturing your best memories, moments, landscape, and selfies in high-resolution and high-quality, and reliving them whenever.
The phone has an internal memory of 16GB and comes with an expandable microSD card slot as well. You can use the expandable memory to store your pictures, movies, videos, music, and important data.
This dual-SIM smartphone supports 4G connectivity and comes with WiFi and Bluetooth technology. Stay connected and enjoy high-quality video and audio calling wherever you are.
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Another hot day outside (and inside) today, and as we do not dare yet to go for a little trip outdoor we set up a little artificial forest and a very tiny super small swimming pool inside my room...I like it, and I hope that some day (soon) I will be able to do a trip outside, see and touch flowers, trees, clouds...sun.
Until then I'm enjoying my staying at home and I'm grateful that nothing wrong has happened. My parents learned how to take care of my trach, how to change the bandage, the trach holder and maybe it does not sound like a big deal but believe me it is!
Picnic :) ?


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The good old days – when a guy could go into a cigar shop, buy a stogie, play cards, or place a bet. That was the face of Omaha's crime syndicate in the early 20th Century.
Blecha's new book, Cigars and Wires, recounts Omaha's criminal past. In those days, Tom Dennison was the crime boss and Mayor James, "Cowboy Jim", Dahlman was his political cohort. Organized crime was alive and well in Omaha! The author has opened a window into Omaha's shady past, showing the reader why political reform was a dire necessity.
Cigars and Wires is a well-researched history of Omaha's criminal underworld from 1911 to the late 1970's, filled with seldom-seen photos of criminals and their locales. A must for the dedicated researcher as well as crime buffs.


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Tuesday, September 15, 2009
What Blog?
Step by step
- Step1
Get started by choosing a site that hosts blogs, often free of charge. Blogger.com, Typepad and LiveJournal are just a few places to get acquainted with.
- Step2
Buy blogging software if you'd like a more involved blog, or would like to learn more. The software isn't necessary to get your blog started, but it can be an added element down the line.
- Step3
Consider registering a domain name that redirects others to the URL of your blog page. You may get more visitors this way.
- Step4
Start writing. A blog can be a great way to share your opinions and tell stories. The more frequently you write, the more visitors you'll tend to receive. Some bloggers try to write daily if possible.
- Step5
Remember that a blog is made public. Never share anything that is too personal or you risk having regrets.
- Step6
Add graphics, animation, polls and other features as you become more acquainted with the world of blogging.


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Construction is putting the brakes on a lot of our commutes.
A portion of River Drive will be closed entirely to traffic from Wednesday morning until Friday.
"We're always excited to get traffic down here," said DeEtte Sexton, who rings up sales and wraps up gifts at Blue Sky gift shop in the Village of East Davenport.
On the minds of shop workers like DeEtte, is construction along River Drive, which has already been affecting business here.
"Some people are not sure how much of a mess it'll be and I don't think it's been a big deal, but I think some people have been afraid of it," said Sexton.
Starting Wednesday at 8 a.m., the portion of River Drive from Bettendorf's border to the Village is closed down to make way for construction crews and equipment there to fix a sewer pipe that's located beneath River Drive.
Drivers going west should take Kimberly Road in Bettendorf to Locust Street, then south on Harrison Street to River Drive.
Anyone going east is recommended to take River Drive, then north on Bridge, then north to Locust.
"We have great, loyal customers and hopefully it'll keep going that way."
Meanwhile, businesses like Blue Sky hope any traffic diverted their way along Mound Street, will result in more customers coming through their doors.
"Any business that potentially drives past us can be very, very helpful. Even after five years, there are people who didn't know we're here. We're always happy when new people find us."
Traffic was reduced down, with some lanes still open initially, but because of the placement of the sewer line, crews will have to shut the entire stretch of road down.
(editor's note: Davenport city officials originally planned to close River Drive Tuesday evening, May 8, following afternoon rush hour. That plan later changed to close the road after Wednesday morning's rush hour.)


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Members' Events
For WAG Members only!
Related Programming
Inuit Fantastic Art
Member's Opening: Inuit Fantastic Art
Thursday, June 12, 2014 from 2pm to 7pm
Members are invited to an exclusive preview of Inuit Fantastic Art. Curator Darlene Coward Wight will be offering guided tours of the exhibition at 3pm and at 5:30pm.
Members may bring a guest but the guest must pay admission.
Gallery Hours
- Tuesday 11am-5pm
- Wednesday 11am-5pm
- Thursday 11am-5pm
- Friday 11am-9pm
- Saturday 11am-5pm
- Sunday 11am-5pm
- Closed Monday


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It's been gloomy around here, folks. And quite frankly, so has my mood. Every time fall daylight savings rolls around and I leave work at 5 pm as the night sky turns black, I start to get edgy. I would appreciate the ability to eat dinner and not feel as though the midnight hour is upon us... … Continue reading Gray Matters
Bad to the Bone
Herringbone, that is. I love incorporating a good herringbone pattern in my designs. Tile, barnwood, décor/accents… I'll take it all. And in honor of Halloween this week, I am offering you a guided tour of these herringbone designs and how you can add in a little zig-zag of your own without breaking the bank. … Continue reading Bad to the Bone
Interior Design is like Scallops.
I ate scallops last night for the first time in my life. It's kinda late in the game, I know. I figured I better make my bucket list a little more attainable now that I have a baby. Fiji is kinda out… therefore, trying scallops. Dream big, right? Anyway, just call me Rachael Ray. I … Continue reading Interior Design is like Scallops.
Say 'shiplap' one more time
It was one of those days. You know the one, fellow mommas. The night before, my six month old daughter chewed up a purple carrot flavored (read: BLUE colored) teething cracker and I discovered about three hours too late that a huge chunk had been stuck in my pony tail for my entire evening group … Continue reading Say 'shiplap' one more time


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Shares of Chicago Mercantile Exchange Holdings Inc. posted their largest single-day fall Tuesday after a Merrill Lynch analyst lowered his rating on the nation's largest futures exchange.
Shares of the Merc fell $7.19, or 5.6 percent, to $122.01, on the New York Stock Exchange.
Colin Clark dropped the Merc's rating to "neutral" from "buy," noting that millions of shares that had to be kept off the market will become eligible for trading on Friday. The Merc became a publicly traded company in December 2002, when shares began trading at $35. Since then, trading of some members' shares has been restricted.


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|Faith on a Walk
My little girl is enjoying her quality time on the leash, though I suspect it's mainly because she gets to nibble on all of the best weeds when we're out. She particularly enjoys poison ivy. I believe that subject is explored in the book "Never Kiss Your Goat on the Lips", though I haven't actually read it. It's on my list!
By the way: poison ivy apparently gives Faith a little...ummm...gas. She's not in the least bit self conscious about it, either. As we were passing the barn, where there were a few people standing around, chatting, she relieved herself...loudly. I was hoping they didn't think it was me! Silly goat.
She's very nervous around Alfie the pot-bellied pig, and Micah the German Shepherd, but otherwise does well. The horses don't seem to bother her, and she actually enjoys greeting people! And when I return her to the herd, she always seems so proud of herself. She always looks up for praise (or treats!) before I unclip her collar.
My goal is to get her to ride in the truck...then to take her through a fast-food drive through. I'll bet THAT would give her gas! I'd also love to take her to school. We'll see!


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I used Mike Angelini for counsel from time to time. I found him very accessible when I needed him and very competent in the field he covered. I recommend him for your legal needs.


text:
The F#.NET Journal just published an article about performance:
"The ability to convert values into legible strings efficiently, a process known as generic pretty printing, has a variety of uses including debugging and serialization. This article takes a look at the characteristics of the built-in pretty printer before considering alternatives including combinators and reflectors with a view to improving performance. Ultimately, a generic solution is proposed that runs 7,600× faster than the built-in F# solution on our test case..."
To read this article and more, subscribe to The F#.NET Journal today!
Background reading on the reference counting vs tracing garbage collection debate - Eight years ago I answered a question on Stack Overflow about the suitability of OCaml and Haskell for soft real-time work like visualization: "*for real-ti...
6 months ago


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|Budget Statement and its Implications for Wales
Mr. Gareth Thomas (Clwyd, West) (Translation): Thank you, Mr. Jones, for your work as Chair of the Committee during this Parliament. As I may not have another chance to do so before the general election, whenever it will be, I thank you for being such a support and inspiration to several hon. Members, especially those who entered the House in 1997. You are an excellent ambassador for your area, and especially Flintshire.
I know that time is against me, but I welcome the Budget. I thank my right hon. Friend the Secretary of State for speaking so eloquently and with such feeling about the social history of this area. One point that came through clearly was that the economy and society of these industrial valleys have had to embrace change. There is a lesson there. We are living in a world that is changing at a fast pace, and not just in our industrial communities. Those of us who live in and love our rural communities must accept the need for change there. Insufficient work has been done in that regard, especially in agriculture. People accept that agriculture is in crisis, and that the Government are dealing with foot and mouth in a practical way, but a long-term strategy for agriculture is needed. I know that the Government are giving priority to that.
I also congratulate my hon. Friend the Member for Cardiff, Central. His point about paying off the national debt in order to invest in youngsters today was original; I had not heard it made in such an effective way before. The main principle of this Government is to create social justice and a fairer society, and that is a strong principle. We should embrace and create a strong economy and control interest rates, which are low now due to the Government's economic success. We now have a much stronger economy than the one that we inherited from the Tories.
I emphasise the significance of the new deal. In my constituency, it has been of great benefit to hundreds of young people. The Government have made strong inroads into unemployment by moving people from dependency on benefit into work. That is a strong point of the Government's policies, which are on the right track, but we must also create jobs that make it pay to work. The Government can be proud of having introduced the minimum wage.
My constituency is highly dependent on tourism, in which pay has traditionally tended to be low. There is a problem with implementing the minimum wage policy that I hope that my right hon. Friend will note. I met a woman in Colwyn Bay who was working in a pub who told me that she was not getting the minimum wage. That was a disappointment and concern to me. Will my right hon. Friend assure me that enough is being done to police the minimum wage?
I understand that time is of the essence. I am happy that emphasis has been placed on measures that will renew and regenerate our community. Tax rebates and tax credits could be of benefit to areas such as Abergele and Colwyn Bay. The Government have achieved a great deal and more will be done if they are re-elected. If we can spread the word about their wonderful record, we can be confident that that will happen.
3.16 pm
Mr. Paul Flynn (Newport, West) (Translation): I have bittersweet memories of this place, where three of us spent time in the 1970s and 1980s. I want to consider changes in education in the context of the Budget. Welsh lessons are held in this building, so Welsh education is another matter that comes to mind. My hon. Friend the Member for Monmouth referred to Caerleon school. I was there on Friday and a group of teachers are teaching children Welsh enthusiastically; for the first time, in my opinion. In the early 1970s, brave parents fought a long battle for their children to receive education in Welsh. We can now celebrate their success with the opening of a new school in the shadow of the Severn bridge, which I believe will be called ``Ysgol y Ffin''the border school. If money comes from the Budget to the Assembly, it is important to ensure that the present generation of Gwent children regain their inheritance, which has been denied them for decades.
I want to refer to the Budget's effect on people in the third world who face suffering each day of their lives. It is possible for the Chancellor to give £1 billion from the Budget to get rid of third world debt. Our Government's success means that we can repay debt. Next year, more debt will be paid back than has repaid during the past 50 years.
[Continued in English] People's jobs will collapse soon. A new atmosphere descended last weekend; hope is disappearing fast. I want to make a strong point to my friends in government. I read this morning that consequential compensation will be paid. Paradise has arrived. We are in the days of socialism when individuals or businesses that lose money are compensated by the Government. Is that happening? I welcome it. However, I want to put in a bid. I shall not talk for long about farmers, but one of the perverse things that could happen is that my steelworkers on modest incomes will lose their livelihood, may never work again and will receive redundancy pay that could be as little as a fifth of what is on offer in other countries in the European Community. At the same time, Sir Brian Moffat, who is a farmer, may receive compensation for losses that he may have suffered in the present crisis. Those are the two extremes of what is happening.
[Continued in Welsh] I wish to refer to people on small farms who speak Welsh. After the job losses in anthracite-producing areas, we must battle for the little farms in Wales.
[Continued in English] Eighty per cent. of the subsidies go to 20 per cent. of the farmers, some of whom are the richest and are running businesses worth many millions of pounds. There must be compensation, but it should be given on the basis of justice and not to save every business in the rural areas. Rural areas have a rich future, but great change will be required.
Tourism is not confined to rural areas; it is an industry also in urban areas. Tourism suffers ups and downs, feast and famine, as a result of weather changes and so on. If there is to be consequential compensation to one industry, it should not be provided for rural areas only. If we are now saying that compensation is for everyone who experiences losses that are not their fault, people in the steel industry should be eligible. What has happened to them is not their fault and, over the years, they have sacrificed, reskilled and done everything that they possibly can; as you know, Mr. Jones, from your experience. For internal, selfish reasons, the company has kicked them in the teeth.
The only way to tackle such behaviour is for unions to work multinationally against multinational companies. The Government should be working with the Dutch and German Governments to ensure at least an equality of standards within the steel industry. What is happening at Llanwern and Ebbw Vale is not happening in Holland or Germany, although our standards of productivity are higher than theirs. If there are to be handouts, they should not go to one industry or group of industries, or to an industry in one area only. They should be given to everyone.
For years, I have represented people in urban areas. We know that the money goes to the squeaking wheel; perhaps we have not squeaked enough. Perhaps we should have demonstrated, protested and blocked the Severn bridge. If multi-millionaires who have vast businesses are to be compensated because they are threatened with bankruptcyeven though such threats are idleour steelworkers should be compensated as well.
The Chairman: Order. Three hon. Members are trying to catch my eye. The winding-up speeches will begin at 3.30 pm.
3.23 pm
Mrs. Jackie Lawrence (Preseli Pembrokeshire): I will keep my comments brief.
I welcome the money for extra public spending in Wales, particularly for education. We have heard banter about facts, figures and GDP. I wish to compare my experiences since becoming a Member of Parliament in 1997 with what happened during the previous 18 years, when I was a county councillor, a governor for two county schools and a parent in Pembrokeshire with three children. I care about children because they are our future.
There were occasions during those 18 years when I was almost in despair. I was a member of the parent-teacher association when my daughter and son were in junior school in Pembroke. We raised money for the school because of our concerns about the Conservative Government's cuts in education spending; only as a result of that fundraising was the school able to afford a new copy of the maths scheme for its pupils. I had to buy my daughter's literature book when she was studying for her GCSEs, because there were only four copies of that book for about 30 children. When I was a councillor, a ceiling in Neyland primary school fell down because of lack of maintenance. When I was a school governor in Pembroke dock, a school with 410 pupils had cardboard walls and difficulties with maintenance and heating.
On Friday, I visited the construction site of a new school in St. Davids. It is being built in partnership with the church in Wales. I used to be a governor in Pembroke dock, which is in the constituency of my hon. Friend the Member for West Carmarthen and South Pembrokeshire (Mr. Ainger). Again, there is a new school for that community.
Fishguard school in my constituency is gaining a new technology block and £750,000 worth of investment. Tasker Milward school in Haverfordwest has had a new sports hall and a new 10-classroom extension. Such things do not come about out of the blue. They come about because of a stable economy and investment by Government in public services. It is important because the children are our future.
My hon. Friend the Member for Cardiff, Central spoke about the repayment of debt, about which some hon. Members complained this afternoon. It is only as a result of the repayment of debt that we have this money for spending on public services. For every £1 of extra public spending in 1997, 42p went on repayment of debt. That is now down to 16p. That is where the money is coming from for our children and their future. That must be good for Wales.
3.26 pm
|©Parliamentary copyright 2001
|Prepared 12 March 2001


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I know what it's like to be frozen and powerless to fear... you may want to laugh, but the Daddy-long-legs spider had a terrifying grip over my life for far too many years.
I'm not quite sure when it all started, but the humble Mr. Long-Legs would cause major turmoil if it crossed my path. I still remember my poor mum having to catch and/or squash every single one before I could enter bedrooms and even toilets. You can imagine then what happened when one crawled right down my face once.
With this in mind, I've been sympathetic, yet extremely keen to see my youngest daughter's fear of 'all things medically related' conquered. Her fear started way back with an injection as a baby, and from that point on any person dressed in a white coat or a white sterile room would send her into a panic. I don't think her need for grommits, and two trampoline accidents needing glue and stitches helped either (here and here).
Anyway, our Doctors have been amazing over the last few years, making sure that her medical experiences have been as stress free as possible, allowing her to visit and just play with the toys, letting her hear her own heartbeat etc. I didn't think this would make much difference but I can honestly say that it has.
The GIANT fear has been striped back to what it really is... reality. Often in reality, the things we fear aren't so horrendous as we imagine them to be. They are like a pack of tiny chihuahuas with megaphones... scary to hear, until you know what they look like.
Yesterday we visited the Doctors once again for her pre-school injections, and although there were a few tears because of the pain (and red jelly bean juice dribbled down my top as she cried softly with her head snuggled into my chest), she made her Mamma super proud.
Unrealistic fears can be overcome with patience, support and prayer. I know this myself too, because Mr Daddy-long-legs doesn't scare me any more either.
Whitetails on the other hand...


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The purpose of this study is to compare the effects, good and/or bad, of a new drug, either alone or in combination with the drug rituximab, with the standard treatment for this disease. The standard treatment is chemotherapy with the drug bendamustine in combination with the drug rituximab. The effects on you and your leukemia will be looked at to find out which treatment is better. Both bendamustine and rituximab are approved by the FDA to treat chronic lymphocytic leukemia (your leukemia type), but the study drug is considered investigational. In this study, you will get either the study drug alone, or study drug with rituximab, or bendamustine with rituximab. If you are in the group that receives bendamustine with rituximab and your disease returns, you will have the option to receive the study drug.
Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.


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Ping is used to check network connectivity and it makes use of the _____________ protocol.
The unit of measurement on a data link layer is _________________
The ___________ command is used to check the connection status to and from your computer.
Port number 88 is used for which of the below protocols?
_______________ is a unique identifier assigned by the manufacturer to a network adapter. This is written in hexadecimal and is of 6 octets.
Switches store the MAC to port translation mapping in a table know as MAC table. It is also known as CAM table. What does CAM stand for?
________________ is a device that regenerates the signal and every time data is sent via broadcast to other connected devices.
The IEEE standard 802.3j is used for ___________________
The 802.3an Ethernet network runs at a speed of ____________
After you configure an IP address and subnet mask on a Windows 7 PC, you want to check the configuration and confirm that the IP and subnet is configured, which of the below command is used.
Question 1 of 10


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Thor 2 Dark World news, speculation and pictures possible Spoilers - Part 8
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Join Date: Oct 2012
Posts: 1,429
Re: Thor 2 Dark World news, speculation and pictures possible Spoilers - Part
and just one or two more little things here. take a look at the scene with Odin and the two boys again. Odin says..
"Only one of you can ascend to the throne, but both of you were born to be kings."
Only one of
those two
boys can ascend to the throne. In other words, Balder is NOT in the picture here. So either little boy Loki already killed Balder, which is *highly unlikely*, or Balder was never there.
Also, note, at the beginning of all of that, Odin does give the impression that it has been some time since he defended Midgard from the Frost Giants. Certainly more than 10 or so years. There has been enough time for them to have "fallen into man's myths and legends". So no, I do not go along with the idea that Asgardian children grow up on a similar timeline to humans. I would agree with hundreds of years to mature (physically at least
). I definitely dont get the impression that Thor has been an "adult" for 1000 years at the beginning of Thor 1.
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Delivering Automated Transactional E-mail
Ensure transactional messages are delivered every time.
Ensure transactional messages are delivered every time.
A ClickZ subscription confirmation e-mail recently wound up in a subscriber's spam folder. Regrettably, this is an all too common situation.
A few years ago, there was no problem getting automated, transactional messages delivered directly from the server that generated them. Volume was low enough and ISP delivery requirements relaxed enough that e-mail got through. There was no need for authentication, whitelisting, or feedback loop registration. Often, delivery was even possible without reverse DNS (define) entries or MX (define) records for response e-mail.
Three things occurred that changed this situation. The first, as I explained last month, is that across-the-board requirements for successful e-mail delivery are getting stricter as ISPs fight to keep spam out of user inboxes. The second is the increasing use of botnets (define) for spam, where many machines send only a small amount of spam each. This means low-delivery rates no longer get a free pass from ISPs. Finally, widespread abuse of Web forms, CGI (define) scripts, and unsecured servers mean many spam-filtering systems now view autogenerated messages with extra suspicion.
Many organizations put a significant amount of effort into managing e-mail marketing campaigns. They monitor, analyze, and track deliverability and negative and positive response data and work hard to ensure lists are properly managed and campaigns are effective. Transactional messages generated for customer service, sales, product support, subscription confirmation, and so forth often come from a variety of sources within an organization and slip under the organizational radar. This is unfortunate, as it means they often don't get the same level of analysis and support even though they're often some of the most important e-mail a company generates.
Failure to follow up on a sales inquiry or customer service request can directly lead to lost revenue. Failure to deliver subscription confirmation requests leads to smaller lists. Failure to deliver subscription notifications can lead to increased complaints and delivery problems for subsequent marketing messages.
The difficulty in most large organizations is political. Transactional messages are often generated by disparate parts of the organization, each of which doesn't wish to surrender control of what it views as essential pieces of their operation. Fortunately, there are steps you can take to address these issues.
Determine what e-mail is sent, what the purpose of each is, and what part of the organization sends it.
Common e-mail sources include:
Determine how well the messages are managed. The simplest approach is to generate and analyze each message type. This should be done from technical, compliance, and messaging perspectives. The same analyses you apply to bulk marketing messages in regard to RFC (define) compliance, authentication, bounce and response handling, and permission management apply to most transactional messages.
Having clear data in hand that demonstrates delivery, legal, or corporate compliance issues is the strongest argument for intervention.
Centralize Delivery
Having many different systems sending e-mail from different sources and with different configurations is a substantial management headache. Yet it's important that different units are able to generate the e-mail they require. Centralize e-mail delivery without necessarily centralizing e-mail generation. This can be achieved in numerous ways, including using an e-mail smart host, routing transactional messages, and standardizing on an API (define) for sending from a single system.
You'll probably wish to keep transactional and bulk e-mail separate, but by having all transactional messages go through a single source with consistent authentication, whitelisting, effective bounce processing, and subscription management, you'll have a much clearer handle on what is and isn't delivered. It will be possible to both identify and resolve delivery issues before they affect your business.
As you would with any bulk mail server, ensure your transactional servers are registered on ISP whitelists and feedback loops. Monitor what's going out, what's coming back in, and how the e-mail is received at major ISPs. In short, treat your transactional e-mail servers the same way you do your marketing servers.
Given transactional messages' importance and the increasing frequency with which they're blocked, they deserve at least as much attention as bulk e-mail. Centralize delivery, then apply the same principles and techniques as you do to marketing campaigns to ensure transactional messages are delivered every time.
Until next time,
Want more e-mail marketing information? ClickZ E-Mail Reference is an archive of all our e-mail columns, organized by topic.


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We all have the picture of our perfect home, but have you really thought about what you want?
Let's look past the distractions and everything we are promised on HGTV. Deciding on your home is a very important process.
First things first your location and size play a huge factor of what you are looking to get. Perhaps you don't need the large home in suburbia, especially for empty nesters. Perhaps it is a good choice to settle for a smaller place in the city. You don't need all the space, however, you are in the heart of it all and can walk out your front door to nearby attractions, places to eat, shop and more. Recent studies have shown even millennials prefer the city life or more urban lifestyle than out in the suburbs. Of course, everyone's opinion is different so make sure to consider what would fit you best.
Also, let's get serious about space and how you want to use it. Is a two-car garage on your new home wish list? What if you and your partner could get by just as well with a spacious carport set beside a mature rose and organic vegetable garden all ready for your enjoyment? And does your family of four really need that spare guest bedroom when you never have overnight guests?
Finally, let's talk bells and whistles! We all get blown away when we see the newest smart home. You can control everything from a panel on the wall or your smartphone. But is it necessary? Homes like that add in extra costs and could max out your budget. Perhaps you want to consider a home that may need a little DIY fixer-upper work, however, the cost may be cheaper.
Just remember it is your home and you want to make it work for you!


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There is a question that should be directed at the republican presidential candidates.
How many people would you hire if you were told you no longer had to pay income tax???
This should put an end to the myth that lowering taxes for the wealthy creates jobs.
Herb Rosen, Margate


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The Mathys Law Group's new debt rebuilding plan is now helping customers reduce debt faster than ever. Full details are available online at www.themathyslawgroup.com.
Los Angeles, CA (PRWEB) August 27, 2013
With a fast track post debt-rebuilding plan, Los Angeles debt relief law firm Mathys Law Group, PC, has created a user-friendly system that allows clients to reduce their debt in a swift and efficient manner. Those seeking debt reduction or bankruptcy protection can log on to The Mathys Group, PC website. Potential clients can supply their debt information and both receive an instant estimate of what might be possible and trigger a free consultation for the law firm's service. After speaking to a representative over the phone, potential clients facing impending financial peril have the power to have the law firm file for immediate bankruptcy for the client. Alternative, the best option may be to enter into a debt relief program. This process allows clients to rebuild their credit in a rapid and pragmatic fashion. The welfare of the client is the firm's top priority.
Marc Mathys has been a licensed bankruptcy attorney since 1982. Mr. Mathys has made it his mission to help clients find relief from debt and financial burdens. Bankruptcy issues differ among clients. Marc Mathys and his trusted team of attorneys and support staff work to ensure that each client is provided the specific care he or she may need. The Los Angeles debt relief law firm offers many services including reducing liability, increasing cash flow, and positioning clients for a fast financial rebuilding process.
Filing for bankruptcy is different for each individual. While some people may need to file bankruptcy, others may be advised to enter into one of the law firm's legal debt resolution programs. This process allows clients to improve their future financial position. Those individuals looking for a bankruptcy attorney in Ventura or a bankruptcy attorney in Camarillo can trust that they have the Mathys Law Group on their side.
Creditors have a history of severely harassing clients. The law firm's staff has a history and detailed knowledge of consumer protection laws and will inform clients about their rights with respect to over debt collectors. The staff will handle all incoming communication and phone calls from debt collectors to ensure that collection is handled in a legally sound manner. The Mathys Group, PC website offers links to educate potential clients about federal collection guidelines, debt collector tactics, and the fair debt collector's act.
The Mathys Group, PC is a bankruptcy law firm and a member of the National Association of Consumer Bankruptcy Attorneys. The Los Angeles bankruptcy law firm is also a Better Business Bureau accredited business.
For more information please visit, http://www.mathyslawgroup.com or call to speak to an expert bankruptcy customer service representative at (877) 404-0572.


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Rybka Opening BooksProduct Code: 10-103
Rybka Opening Books
Product Code: 10-103
Information from Chessbase website:
THIS IS NOT A STANDALONE PRODUCT. You must use this with Rykba 4.
The Rybka 4 opening book is a high-class compilation of opening theory. It was developed for the world�s strongest chess program Rybka3 and will maximize the program�s playing strength. The choice of variations in the book is well suited to the style of the program, and the book has been fine-tuned and checked in thousands of games.
The Rybka Book has a high value outside of computer chess. It reflects the state of current opening knowledge as played in master, correspondence and 100,000 top computer games (up to June 2008). And this is only the starting point: the value of the book lies in its deep original analysis and move choices, which lead to a re-evaluation in many critical points of modern theory. This makes it useful for tournament and correspondence players alike. The book contains a lot of computer-checked analysis never published anywhere before.
The author of the Rybka 4 book is Jeroen Noomen, one of the world�s leading experts in computer opening theory. Jeroen Noomen has been on the Rybka team since the very start, and his preparation has been used in all official events tat Rybka has competed in, including the World Championship 2007 which Rykba won. In his long career as an opening analyst he has discovered many fine novelties in top computer chess events.
Number of positions in the book: 3,387,966. Size 260 MB.
Technical Support on chess software is very limited. Please contact chessbase directly with any installation or technical help.
*This item may ship separately from your order, and expedited shipping may not be available. Please feel free to contact us if you have any questions at all about your order or delivery times.
Customer Ratings & Reviews
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Marvel released yet another teaser poster for the big X-Men event. Please read into it what you will…
Uncanny X-Men #540 arrives in July.
6 Comments
Head scratching to say the least. I am not liking these promos. All my brain is saying is, "…and nothing will ever be the same!"
I wonder if Marvel realizes that the constant revamping of their titles is what keeps making them have to revamp their titles. The books are practically unrecognizable every six months, and then we start the whole mess over again.


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Articles by Gavin Brooks
In JoVE (1)
Other Publications (27)
- Journal of Virology
- Journal of Virology
- Journal of Virology
- The Journal of Biological Chemistry
- The Journal of Pharmacy and Pharmacology
- The Journal of Pharmacy and Pharmacology
- The Biochemical Journal
- Methods in Molecular Biology (Clifton, N.J.)
- Methods in Molecular Biology (Clifton, N.J.)
- Biochemical and Biophysical Research Communications
- Journal of Virology
- Circulation Research
- Journal of Molecular and Cellular Cardiology
- Cardiovascular Research
- The Journal of Pharmacy and Pharmacology
- Free Radical Biology & Medicine
- Molecular Biology of the Cell
- Current Opinion in Pharmacology
- International Journal of Pharmaceutics
- PloS One
- The Journal of Pharmacy and Pharmacology
- Developmental Biology
- Macromolecular Bioscience
- The Journal of Pharmacy and Pharmacology
- BioMed Research International
- Circulation
- Free Radical Biology & Medicine
Articles by Gavin Brooks in JoVE
Inyección de contraste percutánea guiada por ecocardiografía intramiocárdica y entrega de celular en un modelo preclínico grande Alejandro Giraldo*1, Jesús Talavera López*2, Maria Josefa Fernandez-Del-Palacio2, Obdulio García-Nicolás3,4, Juan Seva4, Gavin Brooks1, José María Moraleda5 1Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, 2Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria, Universidad de Murcia, 3Institute of Virology and Immunology (IVI), 4Departamento de Anatomía y Anatomía Comparada, Facultad de Veterinaria, Universidad de Murcia, 5Unidad de Trasplante Hematopoyético y Terapia Celular, Departamento de Hematología, Hospital Universitario Virgen de la Arrixaca, IMIB, Universidad de Murcia Nuevas estrategias terapéuticas en medicina regenerativa cardiaca requieren extensos y detallados estudios en modelos animales preclínicos grandes antes que pueden ser considerados para el uso en seres humanos. Aquí, demostramos una técnica de inyección de contraste percutánea guiada por ecocardiografía intramiocárdica en conejos, que es valiosa para la hipótesis que prueba la eficacia de estas nuevas terapias.
Other articles by Gavin Brooks on PubMed
The Coronavirus Infectious Bronchitis Virus Nucleoprotein Localizes to the Nucleolus Journal of Virology. | Pubmed ID: 11119619 The coronavirus nucleoprotein (N) has been reported to be involved in various aspects of virus replication. We examined by confocal microscopy the subcellular localization of the avian infectious bronchitis virus N protein both in the absence and in the context of an infected cell and found that N protein localizes both to the cytoplasmic and nucleolar compartments.
Localization to the Nucleolus is a Common Feature of Coronavirus Nucleoproteins, and the Protein May Disrupt Host Cell Division Journal of Virology. | Pubmed ID: 11533198 The subcellular localization of transmissible gastroenteritis virus (TGEV) and mouse hepatitis virus (MHV) (group I and group II coronaviruses, respectively) nucleoproteins (N proteins) were examined by confocal microscopy. The proteins were shown to localize either to the cytoplasm alone or to the cytoplasm and a structure in the nucleus. This feature was confirmed to be the nucleolus by using specific antibodies to nucleolin, a major component of the nucleolus, and by confocal microscopy to image sections through a cell expressing N protein. These findings are consistent with our previous report for infectious bronchitis virus (group III coronavirus) (J. A. Hiscox et al., J. Virol. 75:506-512, 2001), indicating that nucleolar localization of the N protein is a common feature of the coronavirus family and is possibly of functional significance. Nucleolar localization signals were identified in the domain III region of the N protein from all three coronavirus groups, and this suggested that transport of N protein to the nucleus might be an active process. In addition, our results suggest that the N protein might function to disrupt cell division. Thus, we observed that approximately 30% of cells transfected with the N protein appeared to be undergoing cell division. The most likely explanation for this is that the N protein induced a cell cycle delay or arrest, most likely in the G(2)/M phase. In a fraction of transfected cells expressing coronavirus N proteins, we observed multinucleate cells and dividing cells with nucleoli (which are only present during interphase). These findings are consistent with the possible inhibition of cytokinesis in these cells.
Interaction of the Coronavirus Nucleoprotein with Nucleolar Antigens and the Host Cell Journal of Virology. | Pubmed ID: 11967337 Coronavirus nucleoproteins (N proteins) localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. The nucleolus is the site of ribosome biogenesis and sequesters cell cycle regulatory complexes. Two of the major components of the nucleolus are fibrillarin and nucleolin. These proteins are involved in nucleolar assembly and ribosome biogenesis and act as chaperones for the import of proteins into the nucleolus. We have found that fibrillarin is reorganized in primary cells infected with the avian coronavirus infectious bronchitis virus (IBV) and in continuous cell lines that express either IBV or mouse hepatitis virus N protein. Both N protein and a fibrillarin-green fluorescent protein fusion protein colocalized to the perinuclear region and the nucleolus. Pull-down assays demonstrated that IBV N protein interacted with nucleolin and therefore provided a possible explanation as to how coronavirus N proteins localize to the nucleolus. Nucleoli, and proteins that localize to the nucleolus, have been implicated in cell growth-cell cycle regulation. Comparison of cells expressing IBV N protein with controls indicated that cells expressing N protein had delayed cellular growth. This result could not to be attributed to apoptosis. Morphological analysis of these cells indicated that cytokinesis was disrupted, an observation subsequently found in primary cells infected with IBV. Coronaviruses might therefore delay the cell cycle in interphase, where maximum translation of viral mRNAs can occur.
Inhibition of E2F Abrogates the Development of Cardiac Myocyte Hypertrophy The Journal of Biological Chemistry. | Pubmed ID: 12682052 Growth of the post-natal mammalian heart occurs primarily by cardiac myocyte hypertrophy. Previously, we and others have shown that a partial re-activation of the cell cycle machinery occurs in myocytes undergoing hypertrophy such that cells progress through the G1/S transition. In this study, we have examined the regulation of the E2F family of transcription factors that are crucial for the G1/S phase transition during normal cardiac development and the development of myocyte hypertrophy in the rat. Thus, mRNA and protein levels of E2F-1, 3, and 4 and DP-1 and DP-2 were down-regulated during development to undetectable levels in adult myocytes. Interestingly, E2F-5 protein levels were substantially up-regulated during development. In contrast, an induction of E2F-1, 3, and 4 and the DP-1 protein was observed during the development of myocyte hypertrophy in neonatal myocytes treated with serum or phenylephrine, whereas the protein levels of E2F-5 were decreased with serum stimulation. E2F activity, as measured by a cyclin E promoter luciferase assay and E2F-DNA binding activity, increased significantly during the development of hypertrophy with serum and phenylephrine compared with non-stimulated cells. Inhibiting E2F activity with a specific peptide that blocks E2F-DP heterodimerization prevented the induction of hypertrophic markers (atrial natriuretic factor and brain natriuretic peptide) in response to serum and phenylephrine, reduced the increase in myocyte size, and inhibited protein synthesis in stimulated cells. Thus, we have shown that the inhibition of E2F function prevents the development of hypertrophy. Targeting E2F function might be a useful approach for treating diseases that cause pathophysiological hypertrophic growth.
Non-steroidal Anti-inflammatory Drugs (NSAIDs) Inhibit Vascular Smooth Muscle Cell Proliferation Via Differential Effects on the Cell Cycle The Journal of Pharmacy and Pharmacology. | Pubmed ID: 12803774 Abnormal vascular smooth muscle cell (VSMC) proliferation plays an important role in the pathogenesis of both atherosclerosis and restenosis. Recent studies suggest that high-dose salicylates, in addition to inhibiting cyclooxygenase activity, exert an antiproliferative effect on VSMC growth both in-vitro and in-vivo. However, whether all non-steroidal anti-inflammatory drugs (NSAIDs) exert similar antiproliferative effects on VSMCs, and do so via a common mechanism of action, remains to be shown. In this study, we demonstrate that the NSAIDs aspirin, sodium salicylate, diclofenac, ibuprofen, indometacin and sulindac induce a dose-dependent inhibition of proliferation in rat A10 VSMCs in the absence of significant cytotoxicity. Flow cytometric analyses showed that exposure of A10 cells to diclofenac, indometacin, ibuprofen and sulindac, in the presence of the mitotic inhibitor, nocodazole, led to a significant G0/G1 arrest. In contrast, the salicylates failed to induce a significant G1 arrest since flow cytometry profiles were not significantly different from control cells. Cyclin A levels were elevated, and hyperphosphorylated p107 was present at significant levels, in salicylate-treated A10 cells, consistent with a post-G1/S block, whereas cyclin A levels were low, and hypophosphorylated p107 was the dominant form, in cells treated with other NSAIDs consistent with a G1 arrest. The ubiquitously expressed cyclin-dependent kinase (CDK) inhibitors, p21 and p27, were increased in all NSAID-treated cells. Our results suggest that diclofenac, indometacin, ibuprofen and sulindac inhibit VSMC proliferation by arresting the cell cycle in the G1 phase, whereas the growth inhibitory effect of salicylates probably affects the late S and/or G2/M phases. Irrespective of mechanism, our results suggest that NSAIDs might be of benefit in the treatment of certain vasculoproliferative disorders.
Targeting the Cell Cycle Machinery for the Treatment of Cardiovascular Disease The Journal of Pharmacy and Pharmacology. | Pubmed ID: 12831500 Cardiovascular disease represents a major clinical problem affecting a significant proportion of the world's population and remains the main cause of death in the UK. The majority of therapies currently available for the treatment of cardiovascular disease do not cure the problem but merely treat the symptoms. Furthermore, many cardioactive drugs have serious side effects and have narrow therapeutic windows that can limit their usefulness in the clinic. Thus, the development of more selective and highly effective therapeutic strategies that could cure specific cardiovascular diseases would be of enormous benefit both to the patient and to those countries where healthcare systems are responsible for an increasing number of patients. In this review, we discuss the evidence that suggests that targeting the cell cycle machinery in cardiovascular cells provides a novel strategy for the treatment of certain cardiovascular diseases. Those cell cycle molecules that are important for regulating terminal differentiation of cardiac myocytes and whether they can be targeted to reinitiate cell division and myocardial repair will be discussed as will the molecules that control vascular smooth muscle cell (VSMC) and endothelial cell proliferation in disorders such as atherosclerosis and restenosis. The main approaches currently used to target the cell cycle machinery in cardiovascular disease have employed gene therapy techniques. We will overview the different methods and routes of gene delivery to the cardiovascular system and describe possible future drug therapies for these disorders. Although the majority of the published data comes from animal studies, there are several instances where potential therapies have moved into the clinical setting with promising results.
Forced Expression of the Cyclin B1-CDC2 Complex Induces Proliferation in Adult Rat Cardiomyocytes The Biochemical Journal. | Pubmed ID: 15253691 Repair of the mature mammalian myocardium following injury is impaired by the inability of the majority of cardiomyocytes to undergo cell division. We show that overexpression of the cyclin B1-CDC2 (cell division cycle 2 kinase) complex re-initiates cell division in adult cardiomyocytes. Thus strategies targeting the cyclin B1-CDC2 complex might re-initiate cell division in mature cardiomyocytes in vivo and facilitate myocardial regeneration following injury.
The Mammalian Cell Cycle: an Overview Methods in Molecular Biology (Clifton, N.J.). | Pubmed ID: 15576929 In recent years, we have witnessed major advances in our understanding of the mammalian cell cycle and how it is regulated. Normal mammalian cellular proliferation is tightly regulated at each phase of the cell cycle by the activation and deactivation of a series of proteins that constitute the cell cycle machinery. This review article describes the various phases of the mammalian cell cycle and focuses on the cell cycle regulatory molecules that act at each stage to ensure normal cellular progression.
Cyclins, Cyclin-dependent Kinases, and Cyclin-dependent Kinase Inhibitors: Detection Methods and Activity Measurements Methods in Molecular Biology (Clifton, N.J.). | Pubmed ID: 15576940 The cyclin/cyclin-dependent kinase (Cdk) complexes and the Cdk inhibitors (CDKI) are crucial regulators of cell cycle progression in all eukaryotic cells. Using rat cardiac myocytes as a model system, this chapter provides a detailed account of methods that can be employed to measure both cyclin/Cdk activity in cells and the extent of CDKI inhibitory activity present in a particular cell type.
Nucleolin is Regulated Both at the Level of Transcription and Translation Biochemical and Biophysical Research Communications. | Pubmed ID: 15925566 Nucleolin is a multi-functional protein that is located to the nucleolus. In tissue culture cells, the stability of nucleolin is related to the proliferation status of the cell. During development, rat cardiomyocytes proliferate actively with increases in the mass of the heart being due to both hyperplasia and hypertrophy. The timing of this shift in the phenotype of the myocyte from one capable of undergoing hyperplasia to one that can grow only by hypertrophy occurs within 4 days of post-natal development. Thus, cardiomyocytes are an ideal model system in which to study the regulation of nucleolin during growth in vivo. Using Western blot and quantitative RT-PCR (TaqMan) we found that the amount of nucleolin is regulated both at the level of transcription and translation during the development of the cardiomyocyte. However, in cells which had exited the cell cycle and were subsequently given a hypertrophic stimulus, nucleolin was regulated post-transcriptionally.
Cell Cycle Perturbations Induced by Infection with the Coronavirus Infectious Bronchitis Virus and Their Effect on Virus Replication Journal of Virology. | Pubmed ID: 16571830 In eukaryotic cells, cell growth and division occur in a stepwise, orderly fashion described by a process known as the cell cycle. The relationship between positive-strand RNA viruses and the cell cycle and the concomitant effects on virus replication are not clearly understood. We have shown that infection of asynchronously replicating and synchronized replicating cells with the avian coronavirus infectious bronchitis virus (IBV), a positive-strand RNA virus, resulted in the accumulation of infected cells in the G2/M phase of the cell cycle. Analysis of various cell cycle-regulatory proteins and cellular morphology indicated that there was a down-regulation of cyclins D1 and D2 (G1 regulatory cyclins) and that a proportion of virus-infected cells underwent aberrant cytokinesis, in which the cells underwent nuclear, but not cytoplasmic, division. We assessed the impact of the perturbations on the cell cycle for virus-infected cells and found that IBV-infected G2/M-phase-synchronized cells exhibited increased viral protein production when released from the block when compared to cells synchronized in the G0 phase or asynchronously replicating cells. Our data suggested that IBV induces a G2/M phase arrest in infected cells to promote favorable conditions for viral replication.
Myostatin Regulates Cardiomyocyte Growth Through Modulation of Akt Signaling Circulation Research. | Pubmed ID: 16763166 Myostatin is a highly conserved, potent negative regulator of skeletal muscle hypertrophy in many species, from rodents to humans, although its mechanisms of action are incompletely understood. Transcript profiling of hearts from a genetic model of cardiac hypertrophy revealed dramatic upregulation of myostatin, not previously recognized to play a role in the heart. Here we show that myostatin abrogates the cardiomyocyte growth response to phenylephrine in vitro through inhibition of p38 and the serine-threonine kinase Akt, a critical determinant of cell size in many species from drosophila to mammals. Evaluation of male myostatin-null mice revealed that their cardiomyocytes and hearts overall were slightly smaller at baseline than littermate controls but exhibited more exuberant growth in response to chronic phenylephrine infusion. The increased cardiac growth in myostatin-null mice corresponded with increased p38 phosphorylation and Akt activation in vivo after phenylephrine treatment. Together, these data demonstrate that myostatin is dynamically regulated in the heart and acts more broadly than previously appreciated to regulate growth of multiple types of striated muscle.
Can the Cardiomyocyte Cell Cycle Be Reprogrammed? Journal of Molecular and Cellular Cardiology. | Pubmed ID: 17362983 Cardiac repair following myocardial injury is restricted due to the limited proliferative potential of adult cardiomyocytes. The ability of mammalian cardiomyocytes to proliferate is lost shortly after birth as cardiomyocytes withdraw from the cell cycle and differentiate. We do not fully understand the molecular and cellular mechanisms that regulate this cell cycle withdrawal, although if we could it might lead to the discovery of novel therapeutic targets for improving cardiac repair following myocardial injury. For the last decade, researchers have investigated cardiomyocyte cell cycle control, commonly using transgenic mouse models or recombinant adenoviruses to manipulate cell cycle regulators in vivo or in vitro. This review discusses cardiomyocyte cell cycle regulation and summarises recent data from studies manipulating the expressions and activities of cell cycle regulators in cardiomyocytes. The validity of therapeutic strategies that aim to reinstate the proliferative potential of cardiomyocytes to improve myocardial repair following injury will be discussed.
Developmental Expression of Myostatin in Cardiomyocytes and Its Effect on Foetal and Neonatal Rat Cardiomyocyte Proliferation Cardiovascular Research. | Pubmed ID: 17368590 Myostatin, a member of the transforming growth factor-beta (TGF-beta) family, plays a key role in skeletal muscle myogenesis by limiting hyperplastic and hypertrophic muscle growth. In cardiac muscle, myostatin has been shown to limit agonist-induced cardiac hypertrophic growth. However, its role in cardiac hyperplastic growth remains undetermined. The aim of this study was to characterise the expression of myostatin in developing myocardium, determine its effect on cardiomyocyte proliferation, and explore the signalling mechanisms affected by myostatin in dividing cardiomyocytes.
The Use of Proteomics to Identify Novel Therapeutic Targets for the Treatment of Disease The Journal of Pharmacy and Pharmacology. | Pubmed ID: 17524226 The completion of the Human Genome Project has revealed a multitude of potential avenues for the identification of therapeutic targets. Extensive sequence information enables the identification of novel genes but does not facilitate a thorough understanding of how changes in gene expression control the molecular mechanisms underlying the development and regulation of a cell or the progression of disease. Proteomics encompasses the study of proteins expressed by a population of cells, and evaluates changes in protein expression, post-translational modifications, protein interactions, protein structure and splice variants, all of which are imperative for a complete understanding of protein function within the cell. From the outset, proteomics has been used to compare the protein profiles of cells in healthy and diseased states and as such can be used to identify proteins associated with disease development and progression. These candidate proteins might provide novel targets for new therapeutic agents or aid the development of assays for disease biomarkers. This review provides an overview of the current proteomic techniques available and focuses on their application in the search for novel therapeutic targets for the treatment of disease.
Nox2 Regulates Endothelial Cell Cycle Arrest and Apoptosis Via P21cip1 and P53 Free Radical Biology & Medicine. | Pubmed ID: 17697942 Endothelial cells (EC) express constitutively two major isoforms (Nox2 and Nox4) of the catalytic subunit of NADPH oxidase, which is a major source of endothelial reactive oxygen species. However, the individual roles of these Noxes in endothelial function remain unclear. We have investigated the role of Nox2 in nutrient deprivation-induced cell cycle arrest and apoptosis. In proliferating human dermal microvascular EC, Nox2 mRNA expression was low relative to Nox4 (Nox2:Nox4 approximately 1:13), but was upregulated 24 h after starvation and increased to 8+/-3.5-fold at 36 h of starvation. Accompanying the upregulation of Nox2, there was a 2.28+/-0.18-fold increase in O2.- production, a dramatic induction of p21cip1 and p53, cell cycle arrest, and the onset of apoptosis (all p
Regulation of Cell Cycle and Stress Responses to Hydrostatic Pressure in Fission Yeast Molecular Biology of the Cell. | Pubmed ID: 17699598 We have investigated the cellular responses to hydrostatic pressure by using the fission yeast Schizosaccharomyces pombe as a model system. Exposure to sublethal levels of hydrostatic pressure resulted in G2 cell cycle delay. This delay resulted from Cdc2 tyrosine-15 (Y-15) phosphorylation, and it was abrogated by simultaneous disruption of the Cdc2 kinase regulators Cdc25 and Wee1. However, cell cycle delay was independent of the DNA damage, cytokinesis, and cell size checkpoints, suggesting a novel mechanism of Cdc2-Y15 phosphorylation in response to hydrostatic pressure. Spc1/Sty1 mitogen-activated protein (MAP) kinase, a conserved member of the eukaryotic stress-activated p38, mitogen-activated protein (MAP) kinase family, was rapidly activated after pressure stress, and it was required for cell cycle recovery under these conditions, in part through promoting polo kinase (Plo1) phosphorylation on serine 402. Moreover, the Spc1 MAP kinase pathway played a key role in maintaining cell viability under hydrostatic pressure stress through the bZip transcription factor, Atf1. Further analysis revealed that prestressing cells with heat increased barotolerance, suggesting adaptational cross-talk between these stress responses. These findings provide new insight into eukaryotic homeostasis after exposure to pressure stress.
Reprogramming the Cell Cycle Machinery to Treat Cardiovascular Disease Current Opinion in Pharmacology. | Pubmed ID: 18243794 Coronary artery disease is one of the most common heart pathologies. Restriction of blood flow to the heart by atherosclerotic lesions, leading to angina pectoris and myocardial infarction, damages the heart, resulting in impaired cardiac function. Damaged myocardium is replaced by scar tissue since surviving cardiomyocytes are unable to proliferate to replace lost heart tissue. Although narrowing of the coronary arteries can be treated successfully using coronary revascularisation procedures, re-occlusion of the treated vessels remains a significant clinical problem. Cell cycle control mechanisms are key in both the impaired cardiac repair by surviving cardiomyocytes and re-narrowing of treated vessels by maladaptive proliferation of vascular smooth muscle cells. Strategies targeting the cell cycle machinery in the heart and vasculature offer promise both for the improvement of cardiac repair following MI and the prevention of restenosis and bypass graft failure following revascularisation procedures.
Effect of Acyl Chain Length on Transfection Efficiency and Toxicity of Polyethylenimine International Journal of Pharmaceutics. | Pubmed ID: 19501146 Polyethylenimine (PEI) is an efficient nonviral gene delivery vector because of its high buffering capacity and DNA condensation ability. In our study, the amino groups on the polymeric backbone were acylated using acetic or propionic anhydride to alter the protonation behaviour and the hydrophilic/hydrophobic balance of the polymer. The concentration of acylated primary amines was determined using trinitrobenzene sulphonic acid assay. Results showed that our modified polymers had lower buffering capacities in solutions compared to PEI. The polymers were complexed with plasmid encoding enhanced green fluorescent protein at three different ratios (1:1, 1:2 and 1:10 w/w DNA to polymer) to form polyplexes and their toxicities and transfection efficiencies were evaluated in HEK 293 cells. Acylation reduced the number of primary amines on the polymer and the surface charge, improving haemocompatibility and reducing cytotoxicity. The reduction in the concentration of amino groups helped to optimise DNA compaction and facilitated polyplex dissociation in the cell, which increased transfection efficiency of the modified polymers compared to the parent polymer. Polymers with buffering capacities greater than 50% and less than 80% relative to PEI, showed higher transfection efficiencies than PEI. The propionic anhydride modified polymers had appropriate interactions with DNA which provided both DNA compaction and polyplex dissociation. These systems interacted better with the cell membrane because of their slightly higher lipophilicity and formed polyplexes which were less cytotoxic than polyplexes of acetic anhydride modified polymers. Among the vectors tested, 1:0.3 mol/mol PEI:propionic anhydride in a 1:2 w/w DNA:polymer composition provided the best transfection system with improved transfection efficiency and reduced cytotoxicity.
Over Expression of Plk1 Does Not Induce Cell Division in Rat Cardiac Myocytes in Vitro PloS One. | Pubmed ID: 19707596 Mammalian cardiac myocytes withdraw from the cell cycle during post-natal development, resulting in a non-proliferating, fully differentiated adult phenotype that is unable to repair damage to the myocardium, such as occurs following a myocardial infarction. We and others previously have shown that forced expression of certain cell cycle molecules in adult cardiac myocytes can promote cell cycle progression and division in these cells. The mitotic serine/threonine kinase, Polo-like kinase-1 (Plk1), is known to phosphorylate and activate a number of mitotic targets, including Cdc2/Cyclin B1, and to promote cell division.
Limitations of the MRL Mouse As a Model for Cardiac Regeneration The Journal of Pharmacy and Pharmacology. | Pubmed ID: 21492166 Myocardial repair following injury in mammals is restricted such that damaged areas are replaced by scar tissue, impairing cardiac function. MRL mice exhibit exceptional regenerative healing in an ear punch wound model. Some myocardial repair with restoration of heart function has also been reported following cryoinjury. Increased cardiomyocyte proliferation and a foetal liver stem cell population were implicated. We investigated molecular mechanisms facilitating myocardial repair in MRL mice to identify potential therapeutic targets in non-regenerative species.
Cellular and Molecular Investigations into the Development of the Pectoral Girdle Developmental Biology. | Pubmed ID: 21741963 The forelimbs of higher vertebrates are composed of two portions: the appendicular region (stylopod, zeugopod and autopod) and the less prominent proximal girdle elements (scapula and clavicle) that brace the limb to the main trunk axis. We show that the formation of the muscles of the proximal limb occurs through two distinct mechanisms. The more superficial girdle muscles (pectoral and latissimus dorsi) develop by the "In-Out" mechanism whereby migration of myogenic cells from the somites into the limb bud is followed by their extension from the proximal limb bud out onto the thorax. In contrast, the deeper girdle muscles (e.g. rhomboideus profundus and serratus anterior) are induced by the forelimb field which promotes myotomal extension directly from the somites. Tbx5 inactivation demonstrated its requirement for the development of all forelimb elements which include the skeletal elements, proximal and distal muscles as well as the sternum in mammals and the cleithrum of fish. Intriguingly, the formation of the diaphragm musculature is also dependent on the Tbx5 programme. These observations challenge our classical views of the boundary between limb and trunk tissues. We suggest that significant structures located in the body should be considered as components of the forelimb.
A Comparison of Thiolated and Disulfide-crosslinked Polyethylenimine for Nonviral Gene Delivery Macromolecular Bioscience. | Pubmed ID: 23749760 Branched polyethylenimine (25 kDa) is thiolated and compared with redox-sensitive crosslinked derivatives. Both polymers thiol contents are assessed; the thiolated polymers have 390-2300 mmol SH groups/mol, whereas the crosslinked polymers have lower thiol contents. Cytotoxicity assays show that both modified polymers give lower hemolysis than unmodified PEI. Increased thiol content increases gene transfer efficiency but also elevates cytotoxicity. Crosslinking improves plasmid DNA condensation and enhances transfection efficiency, but extensive crosslinking overstabilizes the polyplexes and decreases transfection, emphasizing the need to balance polyplex stabilization and unpacking. Thus, at low levels of crosslinking, 25 kDa PEI can be an efficient redox-sensitive carrier system.
Ibuprofen Inhibits Migration and Proliferation of Human Coronary Artery Smooth Muscle Cells by Inducing a Differentiated Phenotype: Role of Peroxisome Proliferator-activated Receptor γ The Journal of Pharmacy and Pharmacology. | Pubmed ID: 24438071 The search for agents that are capable of preventing restenosis and reduce the risk of late thrombosis is of utmost importance. In this study we aim to evaluate the in vitro effects of ibuprofen on proliferation and migration of human coronary artery smooth muscle cells and on endothelial cells.
An Upgrade on the Rabbit Model of Anthracycline-Induced Cardiomyopathy: Shorter Protocol, Reduced Mortality, and Higher Incidence of Overt Dilated Cardiomyopathy BioMed Research International. | Pubmed ID: 26788502 Current protocols of anthracycline-induced cardiomyopathy in rabbits present with high premature mortality and nephrotoxicity, thus rendering them unsuitable for studies requiring long-term functional evaluation of myocardial function (e.g., stem cell therapy). We compared two previously described protocols to an in-house developed protocol in three groups: Group DOX2 received doxorubicin 2 mg/kg/week (8 weeks); Group DAU3 received daunorubicin 3 mg/kg/week (10 weeks); and Group DAU4 received daunorubicin 4 mg/kg/week (6 weeks). A cohort of rabbits received saline (control). Results of blood tests, cardiac troponin I, echocardiography, and histopathology were analysed. Whilst DOX2 and DAU3 rabbits showed high premature mortality (50% and 33%, resp.), DAU4 rabbits showed 7.6% premature mortality. None of DOX2 rabbits developed overt dilated cardiomyopathy; 66% of DAU3 rabbits developed overt dilated cardiomyopathy and quickly progressed to severe congestive heart failure. Interestingly, 92% of DAU4 rabbits showed overt dilated cardiomyopathy and 67% developed congestive heart failure exhibiting stable disease. DOX2 and DAU3 rabbits showed alterations of renal function, with DAU3 also exhibiting hepatic function compromise. Thus, a shortened protocol of anthracycline-induced cardiomyopathy as in DAU4 group results in high incidence of overt dilated cardiomyopathy, which insidiously progressed to congestive heart failure, associated to reduced systemic compromise and very low premature mortality.
P22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels Circulation. | Pubmed ID: 27162237 The NADPH oxidase, by generating reactive oxygen species, is involved in the pathophysiology of many cardiovascular diseases and represents a therapeutic target for the development of novel drugs. A single-nucleotide polymorphism, C242T of the p22(phox) subunit of NADPH oxidase, has been reported to be negatively associated with coronary heart disease and may predict disease prevalence. However, the underlying mechanisms remain unknown.
Aging-associated Metabolic Disorder Induces Nox2 Activation and Oxidative Damage of Endothelial Function Free Radical Biology & Medicine. | Pubmed ID: 28499911 Oxidative stress attributable to the activation of a Nox2-containing NADPH oxidase is involved in the development of vascular diseases and in aging. However, the mechanism of Nox2 activation in normal aging remains unclear. In this study, we used age-matched wild-type (WT) and Nox2 knockout (KO) mice at 3-4 months (young); 11-12 months (middle-aged) and 21-22 months (aging) to investigate age-related metabolic disorders, Nox2 activation and endothelial dysfunction. Compared to young mice, middle-aged and aging WT mice had significant hyperglycaemia, hyperinsulinaemia, increased systemic oxidative stress and higher blood pressure. Endothelium-dependent vessel relaxation to acetylcholine was significantly impaired in WT aging aortas, and this was accompanied by increased Nox2 and ICAM-1 expressions, MAPK activation and decreased insulin receptor expression and signaling. However, these aging-associated disorders were significantly reduced or absent in Nox2KO aging mice. The effect of metabolic disorder on Nox2 activation and endothelial dysfunction was further confirmed using high-fat diet-induced obesity and insulin resistance in middle-aged WT mice treated with apocynin (a Nox2 inhibitor). In vitro experiments showed that in response to high glucose plus high insulin challenge, WT coronary microvascular endothelial cells increased significantly the levels of Nox2 expression, activation of stress signaling pathways and the cells were senescent, e.g. increased p53 and β-galactosidase activity. However, these changes were absent in Nox2KO cells. In conclusion, Nox2 activation in response to aging-associated hyperglycaemia and hyperinsulinaemia plays a key role in the oxidative damage of vascular function. Inhibition or knockout of Nox2 preserves endothelial function and improves global metabolism in old age.


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Tessera in Latin is the individual tile, usually formed in the shape of a cube used in creating mosaics. It is also number 4 in Greek. Tessera is a handcrafted line of products built with leather-bound walnut units of 4x4x4cm. Tessera questions rigidity, flexibility, assemblage, pattern, and modularity. Increasingly more defined, detailed, and fragile, but at the same time progressively more three-dimensional.
Carwan commission, produced in Lebanon 2012
About Marc Baroud
Lebanese architect and product designer Marc Baroud has an extensive oeuvre, ranging from furniture and luxury product design to corporate building projects. After completing his degrees in interior architecture and furniture design from the Académie Libanaise des Beaux-Arts (where he has been teaching since 2004 and is now head of the design school), as well as studying industrial design in Paris, Baroud established a brand development company in Beirut and later, co-founded RGMB-ad, a multidisciplinary architecture and design firm that designs domestic homes in addition to corporate, retail, and office spaces. As a furniture designer, Baroud is concept-driven and innovative; his "Tessera" series is constructed of 4 x 4 x 4 cm circular units that are bound by a band of leather and formed into furniture. Confronting the idea of fragility, his Tessera Lounge Chair is in fact a fully functional recliner.
Lebanese, based in Beirut, Lebanon


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Varscona Theatre
10907 Whyte Avenue NW,
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The Odeon chain opened the Varscona Theatre on July 6, 1940. The single-screen theatre seated 499. Famous Players took over running the Varscona Theatre in 1982.
The Varscona Theatre was closed in 1986 and it was demolished in 1987. A Shoppers Drug Mart now stands on the theatre site.
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A photo of the Varscona can be seen here.
Lawrence Herzog's brief article on the Varscona Theatre (the last listing on this web page) says that it was opened on July 6, 1940, and was designed by the architectural firm of Rule, Wynn, & Rule (John Rule, Gordon Wynn, and Peter Rule) in a Streamline Modern style. The Varscona Theatre was demolished in 1987.
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KPMG in Slovakia is proud partner of the TREND TOP 2016 Manager of the year and Investor of the year.
8 November 2016, 7:00PM - 10:00PM, CET
Manager of the year is a traditional award established by TREND weekly in 2005. Investor of the year will be awarded for the first time. The winners will be announced on November 8, 2016 at a gala event TOP TREND 2016.


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In this HP Pavilion 500-590 review, let's take a good look at the latest addition to the Pavilion series from HP. This desktop computer comes with a decent price tag and targets mainly light and mid range users who might require little power to get things done.
If you are searching for a computer with latest specs within a budget, then this one might be worth considering. Read this full review and see if this is the desktop PC you've been waiting for.
The HP Pavilion 500-590 desktop PC comes with a glossy design in the front. This gives the desktop a premium look. There are a number of ports in the front which is great for accessibility. Rest of the ports can be found at the back. Ventilation is enabled through the sides and works as expected.
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This might not be the smallest desktop you've seen. With dimensions of 15.35 x 6.91 x 14.48 inches, the device weighs around 15.8 pounds which isn't that light. But that doesn't matter as we're not going to keep on moving it as if it is a laptop. Overall, it's a pretty good design and not that bad at all for a budget PC.
HP Pavilion 500-590 Specs
The HP Pavilion 500-590 is not a very powerful desktop. Yes it can get things done but not high end system intensive stuff. It was made that way which is why they have chosen the Intel core i3 processor to power. This is a 4th gen processor that clocks at 3.4GHz and has a 3MB cache.
Don't get me wrong. You can still get a boatload of stuff done. You can stream videos online, play games, browse the web, work on your office docs and even edit some photos every now and then. If you are a light or a mid range user who needs a machine for home, this PC will not falter.
Not many people will be amused when we say this device comes with 4 gigs of RAM. Some will even ask what the point of 4GB is in 2015 which is a good question. But the truth is you can do a lot of stuff at the same time even with a 4GB SD RAM.
You can multiple applications at the same time. You can play music; work on your office stuff while downloading software that you need urgently. All these can happen without any lag in performance. Do you want to run a virtual machine? Well, that's not possible with this kind of memory. Sorry about that.
The hard drive of this HP Pavilion 500-590 computer comes with a capacity of 1TB. The drive has a rotational speed of 7200RPM which is faster than the 5400RPM drives. This drive gives you both space and speed which is a great thing.
Great news for people who absolutely hate Windows 8. The operating system here is Windows 7 professional which is loved by people. It comes pre-installed in the hard drive. You can upgrade to Windows 10 for free if you wish. You'll be able to do that once it releases this summer.
The next thing we'll see in this HP Pavilion 500-590 review is the graphics card. The GPU here is an integrated Intel HD 4400 graphics card. This is a decent graphics card for both rendering and moderate gaming. If you are a hardcore gamer, then you might find this setup a bit on the lower side. We recommend you to look at some full-fledged gaming desktops.
There are 4 USB 3.0 ports which can transfer data in seconds and also help in external connectivity. There desktop offers support for 802.11b/g/n wireless standard. There is also a super multi DVD drive which can be very handy of course.
HP Pavilion 500-590 Review: Verdict
This new addition to the Pavilion series from HP is a very good computer for the price. It offers good flexibility and will get things done for both the light and mid range users. Without doubt, this desktop is perfect for day to day activities. If you need an everyday desktop without paying a lot of money, this is good choice.
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Of course you do, it's a Friday afternoon! Most of you have mere hours to go until you're free from work and staring lovingly into the open arms of the weekend, where time with Dead Island and Warhammer 40K: Space Marine are a reality. Isn't being a gamer awesome?
Until the weekend officially lands, let's mutilate the last few hours of our Friday afternoon work day by watching twenty glorious minutes of upcoming action RPG Kingdoms of Amalur: Reckoning. We had hands-on time with the game at Gamescom, and Geoff got the chance to interview the game's lead designer, Ken Rolston, a while back.
It's shaping up to be one of my most anticipated titles for 2012. Once Skyrim has successfully molested my social life and I've freed myself from its clutches, I'll have Amalur to look forward to in February next year. After watching this in-depth look at the game, you will too![youtube]E_WEkRTSzqQ[/youtube]


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Kecoughtan's Mike Niemotka pitched a four-hit shutout and drove in a run with a double as the Warriors handed visiting Menchville a 2-0 defeat. It was the first Peninsula District loss for the Monarchs (4-1, 5-2).
Stevie Pabst singled with one out in the third inning and advanced to second on a wild pitch, and Niemotka promptly doubled him home. Andy Shat . 0000.00tuckthen hit an RBI single for the game's only other run.