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Synthetic Biology: Building Life (Potential & Dangers ...
But today, applications of our understanding of DNA in areas such as genetic engineering and cloning seem primitive compared to synthetic biology, a field in which the basic building blocks of life are pieced together from scratch to suit the needs of research, medicine, and the environment. Synthetic biology combines knowledge of genetics and cell biology with principles of engineering and is limited only by scientistsâ imaginations. But the field is still in its infancy, and initial ventures into figuring out how best to put the basic components of DNA together synthetically have [more...]
Date: 2009-03-10 17:15:19
Blog posts
DNA Transcription (Advanced)
Transcription is the process by which the information in DNA is copied into messenger RNA (mRNA) for protein production. Originally created for DNA Interactive ( http://www.dnai.org ). TRANSCRIPT The Central Dogma of Molecular Biology: "DNA makes RNA makes protein" Here the process begins. Transcription factors assemble at a specific promoter region along the DNA. The length of DNA following the promoter is a gene and it contains the recipe for a protein. A mediator protein complex arrives carrying the enzyme RNA polymerase. It manoeuvres the RNA polymerase into place… inserting it with [more...]
Date: 2010-10-03 03:02:09
Healing Dna With Light, Sound And Acupuncture
There are many other ways to enhance the torsion field in our body like sunlight, negatively charged fresh air, clean water, natural medicines, and healthy foods. Another way to improve and repair DNA on a cellular level is acupuncture. Acupuncture can be used on the pericardium and heart meridians to activate the thymus gland and improve immune function. This can be very useful in treating autoimmune diseases. Increased the energy in these meridians can activate higher frequencies. Higher frequencies lead to lower cellular oxidation rates and less cellular aging. Acupuncture on the Du [more...]
Date: 2010-09-07 12:05:19
Antibody Therapies and the New Generation of DNA Sequencing ...
Our antibody database targets protein-coding genes. Although they form only 1% of the total human genome, they account for 85% of the mutations that lead to disease. DNA sequencing (defining the sequence of the 4 base amino acids within the DNA strand) and then using antibodies specific to those sequences, is a vital part of disease research. Sanger sequencing is the standard for doing this. However, in 2007 a next generation (or next gen) sequencing technique was devised. Lauded as the biggest advancement in genomics since microarray technology, it has radically improved diagnostic [more...]
Date: 2010-09-27 10:34:46
Think Out Loud Sizing Up Your Genes · Oregon Public Broadcasting
Now, a host of startup companies are selling at-home kits that promise to unlock the secrets of customers' DNA in a matter of weeks. Intel employees, who get a discounts from two genetic testing companies, use the tests to reveal their genetic predisposition to everything from cancer to cellulite. But many in the medical community are skeptical of the tests' legitimacy, and the U.S. Government Accountability Office recently released a report calling the tests "misleading" and accusing the companies administering them of "questionable practices." Have you elected to use genetic testing? If [more...]
Date: 2010-08-11 16:00:00
Senior Software Engineer - SEQanswers
Complete Genomics is an emerging DNA sequencing technology with the promise of high throughput, low cost sequencing of human genomes. The technology has proven itself by sequencing of hundreds of human genomes for customers from research institutions to pharmaceutical giants to clinical researchers. Complete Genomics is aggressively pursuing innovations to aid its customers in the study of human disease and to push its service into vast new markets. It has filed an S1 for IPO. The assembly pipeline team is an amalgam of exceptional bioinformaticians and software engineers of diverse [more...]
Date: 2010-10-01 18:28:02
Popular Mechanics Posts 2010 BREAKTHROUGH Awards — The Gadgeteer
While working at the National Institutes of Health in the early 1990s, Venter developed a way to rapidly discover genes by exploiting snippets of DNA called expressed sequence tags. In 1992, he founded The Institute for Genomic Research, and, three years later, he and a team decoded the first genome of a free-living organism. That led to Venter's best-known breakthrough, mapping the human genome. Last May, he achieved a defining moment in the history of biology when he inserted digitally created DNA into a living bacterium, forming the first synthetic life. His ultimate goal is to design [more...]
Date: 2010-09-28 20:43:25
Job4Dev - Bioinformatics & Machine Learning Expert em DNAnexus ...
DNAnexus is recruiting an expert in bioinformatics and machine learning to help architect and implement the next generation of scalable, intelligent algorithms for DNA sequence analysis. Requirements: Practical experience with Bayesian modeling and inference, machine learning, statistics, and optimization Familiarity with DNA sequence data, Smith-Waterman, BLAST, etc., and the ability to implement the algorithms Comfortable working in distributed environments and architecting parallel algorithms Fluent in C/C++ and understand the implications of your coding style down to the level of machine [more...]
Date: 2010-09-25 13:09:24
IVF News - Sperm linked to ART-related genetic disorders
A process called DNA methylation is critical to imprinting. A team led by Dr Takahiro Arima from Tohoku University examined DNA methylation in 78 six to nine-week-old embryos and fetuses conceived using ART, and 38 conceived without ART. They also examined the father's sperm and DNA. In seven of 17 cases where there was abnormal DNA methylation in the ART sample, identical alterations were present in the father's sperm. The abnormal DNA methylation in the sperm was associated with variations in a gene coding for DNMT3L - a key enzyme in DNA methylation associated with abnormal imprinting and [more...]
Date: 2009-12-07 08:00:00
Evolution News & Views: When "Junk DNA" Isn't Junk: Farewell to a ...
In the Darwinist repertoire, a standard response to evidence of design in the genome is to point to the existence of "junk DNA." What is it doing there, if purposeful design really is detectable in the history of life's development? Of course this assumes that the "junk" really is junk. That assumption has been cast increasingly into doubt. New research just out in the journal Nature Genetics finds evidence that genetic elements previously thought of as rubbish are anything but that. The research describes tiny strands of RNA, previously thought to be junk, that now turn out to play a role in [more...]
Date: 2009-04-28 16:20:29
CIENCIASMEDICASNEWS: Researchers report MALAT1 gene regulates pre ...
Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing - a critical step in the earliest stage of protein production. Their study appears in the journal Molecular Cell. Nearly 5 percent of the human genome codes for proteins, and scientists are only beginning to understand the role of the rest of the "non-coding" genome. Among the least studied non-coding genes - which are transcribed from DNA to RNA but generally are not translated into proteins - are the long non-coding RNAs (lncRNAs). Before the human genome was [more...]
Date: 2010-10-01 22:18:00
Assassin's Creed II Cheats : Latest Game Cheat Codes
Bloody Sunday (30): Complete DNA Sequence 4. Undertaker (20): Discover the Assassin's Tomb inside the catacombs under Santa Maria Novella. The Conspirators (30): Complete DNA Sequence 5. An Unexpected Journey (30): Complete DNA Sequence 6. Bleeding Effect (30): Complete training and reenter the Animus. The Merchant of Venice (30): Complete DNA Sequence 7. The Impenetrable Palazzo (30): Complete DNA Sequence 8. Masquerade (30): Complete DNA Sequence 9. Bianca's Man (30): Complete DNA Sequence 10. The Prophet (30): Complete DNA Sequence 11. The Vault (30): Complete DNA Sequence [more...]
Date: 2010-10-06 01:05:17
Mutant gene discovery in Jews may stop brain damage | Sevarth
As the disease is both severe and common, testing for these mutations will probably soon become a routine prenatal genetic screening test in these two populations so that future cases can be prevented, by carriers either not marrying each other or having children together, or by abortion or pre-genetic diagnosis to choose healthy embryos for in-vitro fertilization. Prof. Ohad Birk and doctoral student Orly Agamy of the National Institute for Biotechnology in the Negev at BGU and colleagues at Soroka University Medical Center in Beersheba demonstrated the first human disease associated with a [more...]
Date: 2010-10-12 07:23:13
50. Gene Technology 3 of 6 : : Dna Test
Finally we look at some of the tricks that can be done using these tools and techniques – such as DNA profiling and fingerprinting; how to sequence DNA – from a molecule to a letter code we can interpret; and finally we look at how cloning genes and the use of recombinant DNA technology allows us to mix the DNA of different species together. Lots of information. Always a [more...]
Date: 2010-10-12 23:20:03
skin cancer mapping | Cancer Blog
Investigators are still analyzing parts DNA from patients who are non-coded, and can still find other mutations, said Dr. Elaine Mardis, co-director of Center Sequencing genome at the University of Washington, and co-lead author of the study. But as she explained: The role of these mutations Non-coding is more difficult to solve because we do not yet fully understand the function of this part of the genome. Another interesting finding in this study was that when they compared the 8 new mutations in the patient with the DNA of tumor samples from 187 AML patients others there were no matches: [more...]
Date: 2010-10-12 17:22:34
EveryDay Science » Blog Archive » New roles for new genes ...
Thanks to new technological advances in genomic sequencing , we know that much of the DNA genome is transcribed into RNA but only a small portion of this RNA (transcriptome ) contains sequences that encode for the synthesis of proteins. Thus, although long RNA fragments are non-coding transcriptome most mammals, their cellular functions are still unknown. Scientists have already described the role of small RNAs in gene regulation but we still know very little about the long fragments . The long noncoding RNAs are RNA fragments longer than 100 nucleotides. The authors of this paper have shown [more...]
Date: 2010-10-01 14:35:23
Because no one will win the debate on human evolution!
All persons have the same 100% human genes and DNA sequence-based links to an African matriarch. I refer readers to 11th January 1988 cover story in Newsweek that the DNA of humans navigate on the River. This article has been shown that evolutionists have to search, but we are afraidWrite: All people are a unique rainbow family combined. We have the saliva, the same blood type, the same shit and the same disgusting habits: we are not many, but One Race A dysfunctional family! The fact that some pre-human species changed, does not mean that all people have done things before the same thing? [more...]
Date: 2010-10-09 17:50:37
The effect of DNA signals on nucleosome formation, chromatin ...
Much of the human genome is non-coding and it seems likely that at least some of the non-coding DNA is functionally important. However, only little is known about the possible function of the bulk of the human genome. Since essentially all the nuclear DNA is packaged into chromatin, it is likely that functional effects of non-coding DNA are mediated by the chromatin structure. By making use of human genomic sequence information now available, we showed that a specific set of periodic DNA motifs (period-10 VWG/CWB) encoded in genomic DNA is predicted to influence human chromosome function. The [more...]
Date: 2010-08-25 23:15:17
University of California - UC Newsroom | State order alters DNA ...
In July, incoming students received a packet of information about the DNA testing program, a saliva kit, an anonymous bar code to attach to the sample, and a consent form authorizing the campus to test for three gene variants that would reveal aspects of how an individual metabolizes milk, alcohol and vitamin B9 (folic acid). The campus has scheduled a series of lectures, panel discussions and class sessions - which will go on as planned - around the subject of genetic testing. "Of the three million genetic differences that distinguish any two people, we are testing only three common [more...]
Date: 2010-08-12 16:00:00
DNA repair causes damage - The Scientist - Magazine of the Life ...
A supposedly accurate DNA repair mechanism employed by cells to fix double-strand breaks can surprisingly increase the nearby mutation rate by up to 1400 times, providing a possible explanation for the accumulation of tumor-causing mutations in cancerous tissues. Previously, "we saw that DNA breaks are present in precancerous legions," said molecular oncologist Thanos Halazonetis of the University of Geneva, who did not participate in the research. "These breaks, based on this finding now, could perhaps explain mutations in oncogenes that drive cancer progression." Cancer [more...]
Date: 2007-08-27 07:00:00
CIENCIASMEDICASNEWS: New Functions For New Genes, Non-coding RNAs ...
DNA regions have been known for many years to confer both negative and positive regulation of protein synthesis. "The fact that RNA is much easier to manipulate than DNA could mean that this discovery has a vast therapeutic potential" explains Ørom. The work has been led by Ramin Shiekhattar, group leader at the Centre for Genomic Regulation (CRG) in Barcelona and now at the Wistar Institute and co-authored by Cedric Notredame and Roderic Guigo from the Bioinformatics and Genomics Programme at the Centre for Genomic Regulation (CRG). Shiekhattar and collaborators have seen a new role for a [more...]
Date: 2010-10-08 13:03:00
O.N.L.Y 1 %: 10 Tips For Better DNA Gel Extraction Results
Nabi s.a.w bersabda, maksudnya: Jabir mengatakan bahawa Rasulullah s.a.w pernah bersabda, "Wahai manusia, aku telah meninggalkan untuk kalian 2 perkara. Jika kalian menggunakannya tidak akan tersesat selamanya iaitu Al-Quran dan Ahlul Bait keturunanku." (HR At-Tarmizi dan ia menghasankannya) What is it about gel extraction of DNA that makes it a pain? Maybe it's poor product yields or maybe it's because the process uses harsh chemicals (chaotropic salts, ethidium bromide, ethanol, heat) that will damage or denature DNA and potentially decrease cloning success. In this article I share some [more...]
Date: 2010-10-11 04:17:00
Welcome to Amino Acids: Amino Acid Translation
The process of copying genetic information from DNA into RNA is called____ protein synthesis replication transcription duplication translation DNA synthesis ___is unique to DNA. adenine cytocine uracil thymine guanine A mRNA sequence with 30 nucleotides codes for______ 15 amino acids 90 amino acids 10 amino acids 3 amino acids Translation is a process which converts the information in ____into ___ "DNA, mRNA" "mRNA, DNA" "protein, DNA" "mRNA, protein Get the answers... Missense mutation in which part of KRT5 gene does epidermolysis bullosa with mottled pigmentation form? (Answers: 1) [more...]
Date: 2008-01-19 08:00:00
Insights into watermelon genetic diversity
Insights into watermelon genetic diversity by Jeremy on September 29, 2010 There's no doubt that most of the time when we non-experts think of genetic diversity in DNA terms, we think about alterations in the actual DNA sequence. Change the genetic code and there's a chance you change the nature of a gene and as a result change the outward appearance, the phenotype, of an organism. There have been lots of studies relating the differences among species to differences in the DNA code of this sort, but far fewer looking at the differences among varieties of a single species. Amnon Levi and [more...]
Date: 2010-09-29 05:55:20
Junk DNA and Complexity Science: A Sad mix
A quote from an extremely mediocre book, Complexity: A Guided Tour. Like most people coming out of the 'complexity sciences', the author has a mediocre grasp of molecular biology, both current developments, and the history of the field. It's frustrating that these network people keep hyping supposedly new revolutionary discoveries made the past 10 years of the genome era - discoveries, that in fact have been known for decades. For people clearly new to biology, molecular biology before the year 2000 was a big black hole of ignorance. There are several claims that make me angry in this book, [more...]
Date: 2010-05-21 19:56:10
Blood tests for mitochondrial disease | MitoAction
MEDomics sequences the entire mitochondrial DNA genome thousands of times. That sometimes allows the diagnosis of mitochondrial disease to be made with a blood sample rather than with painful muscle biopsies. MitoDx is a test of unprecedented power for diagnosing mitochondrial genome disease, which is roughly "half the elephant" of mitochondrial disease. Interesting download here - "How does mitochondrial disease manifest itself?"Join us this Thursday, September 16th, at noon Eastern time (US) -- dial in at 1-866-414-2828, participant code 017921# -- as Dr. Sommer discusses: * [more...]
Date: 2010-09-14 17:39:35
The cancer holy grail: DNA test will allow doctors to create ...
The researchers at Johns Hopkins took six sets of cancerous and normal tissue from four bowel and two breast cancer patients and "sequenced" – or decoded – the complete set of DNA for each patient. By comparing DNA from healthy and cancerous tissue, the researchers could spot where large parts of genetic code had been altered. These changes occur only in cancer cells, making them ideal biomarkers for the disease. Once the researchers found areas where DNA had been rearranged, they looked for the same changes in DNA shed from tumours into the patients" blood. Using blood samples [more...]
Date: 2010-09-29 21:36:09
Human DNA : Surprisingly Diverse
Human DNA : Surprisingly Diverse Agençe France-Presse 23 November 2006 Source: www.abc.net.au New investigations into the code for life suggest the assumption that humans are genetically almost identical is wide off the mark, and the implications could be resounding. Current thinking, inspired by the results five years ago from the Human Genome Project, is that the 6 billion humans alive today are 99.9% similar when it comes to genetic content and identity. But research published today in the journal Nature suggests we are genetically more diverse. The repercussions could be far-reaching [more...]
Date: 2010-10-08 11:11:33
Genetic Technologies Ltd.?s Non-coding DNA Patent Upheld on ...
s (GTG's) patent for non-coding DNA technologies. U.S. Patent No. 5,612,179 titled "Intron sequence analysis method for detection of adjacent locus alleles as haplotypes" claims a method for facilitating the detection of specific gene variations. The third party initiated ex parte re-examination Control No. 90/010,318, was filed on October, 15, 2008 requesting that each of claims 26-32 be found invalid in view of a new reference, which was not previously cited in the prosecution of the '179 patent; namely a printed publication titled "Comparison of Multiple HLA-A Alleles at the [more...]
Date: 2010-07-13 16:50:00
Engineering Mini project: DNA COMPUTERS
After seven days of intensive laboratory work, Adleman's test-tube contained the answer to the problem, subsequently visible as a series of dark bands on a DNA sequencing gel. On the face of it, it might hardly seem worth the bother, especially as Adleman already knew the answer before he started the experiment. But this was much more than a curious laboratory stunt. During the initial 'linking-up' stage of the process, Adleman's test-tube computer effectively performed an astonishing 10^14 calculations. And it did so with the consumption of only a tiny amount of energy, and in a tiny [more...]
Date: 2010-10-12 10:10:00
Cyber-hugs and robot babies – a brave new world « Gleeful ...
Scientists in the US have just succeeded in developing the first living cell to be controlled entirely by synthetic DNA. The researchers copied an existing bacterial genome. They sequenced its genetic code and then used 'synthesis [more...]
Date: 2010-10-11 09:51:46
LinkNotes: The Science of Chocolate -- Preliminary Cacao Genome ...
Can science make chocolate taste (even) better? - The WeekScientists have cracked the DNA code of the cacao plant. Will our future selves be tempted by yet yummier sweets? Chocolate isn't an obvious candidate for a food that needs improving. But that hasn't deterred scientists at the candy conglomerate Mars, which recently announced they had nearly completed sequencing the cacao tree's genome. This could mean stronger, more resilient cocoa crops, and — perhaps down the road — better-tasting [more...]
Date: 2010-09-25 13:15:00
GeneDesign automates the process of determining which base pairs -- the building blocks of DNA -- should be linked together in a particular order to make a gene, according to Jef Boeke, Ph.D., professor of molecular biology and genetics and ... the tasks required to design and manipulate synthetic DNA sequences. The program allows the user to start with either the sequence of the amino acid making up the protein or the bases making up the gene that codes for that protein. [more...]
Date: 2006-02-15 08:00:00
FDA, Walgreens Puts Pathway Genetic Test Sales on Hold
FDA, Walgreens Puts Pathway Genetic Test Sales on Hold Walgreen's drug stores originally had plans to launch the retail sale of an at-home genetic test on Friday that allows the consumer to assess his or her risk for diseases such as breast cancer, heart disease, and Alzheimer's. The nation's largest drugstore chain has opted to put sales on hold after an FDA warning that the test is not approved and could put consumers at risk. The test requires FDA authorization because it involves a device that allows consumers to collect their own DNA. The agency is also concerned about the fine [more...]
Date: 2010-05-13 12:20:02
Claim of Having Created Synthetic Life Is Far Overblown
A valid claim of creating synthetic life would require that – Even absent an agreed-upon ethics-based definition of "synthetic life," a common sense definition would require that: (1) The synthetic DNA coding and sequencing not slavishly copy a known life form. Otherwise Life has done all the work in evolutionarily stumbling upon a coding sequence and organization that can self-replicate an organism on its own. (2) The synthesized DNA must either (a) code its own contents-enclosure (cell wall for bacteria) or (b) be placed in equally novel, human-created container, rather than [more...]
Date: 2010-06-18 13:37:40
MyJournals.org - 'Screening of the DNA mismatch repair genes MLH1 ...
Screening of the DNA mismatch repair genes MLH1, MSH2 and MSH6 in a Greek cohort of Lynch syndrome suspected families (BMC Cancer) Background: Germline mutations in the DNA mismatch repair genes predispose to Lynch syndrome, thus conferring a high relative risk of colorectal and endometrial cancer. The MLH1, MSH2 and MSH6 mutational spectrum reported so far involves minor alterations scattered throughout their coding regions as well as large genomic rearrangements. Therefore, a combination of complete sequencing and a specialized technique for the detection of genomic rearrangements should be [more...]
Date: 2010-10-11 16:25:57
William Hay, Writer: Da Vinci Code and Christian Flesh
Tom Hanks in Da Vinci Code finds the divine sequence in a DNA and that Divine sequence gets passed on through generations. The actual DNA gene studies suggest that we all have all the DNA but that certain areas are blocked and others are highlighted. It's more complicated than we once thought. We once thought that if we were missing a bit then we'd not have an eye per se but it turns out that the DNA like the Synapses are multi referenced and repeat so that really the 'code' is all there but it's not read for whatever reason. Indeed the whole human genome is in a bit of buccal smear. [more...]
Date: 2010-10-11 08:38:00
When the disease strikes – Who You Gonna Call?
Viruses can mutate (change their DNA or RNA structure), and therefore influenza strains provide researchers with the daunting task against the strain of the virus at their own gameTransfiguration, from different strains of the virus injection allows a vacation to make the body enough so that the antibodies in our immune system will not fall victim to a full-scale attack. Covering us with different strains in one shot, maybe some parts of the sequence of points in the immune system of our body, making these antibodies stimulated by these specific charges or other charges that some who have [more...]
Date: 2010-10-04 12:50:32
Medical Transcription From Home: What Is The Difference Between ...
DNA replication is the process by which one double helix of DNA is duplicated into two identical double helices which are also identical to the mother DNA. Translation is taking the RNA just made and using it to make a protein. Translation takes place after transcription of the genetic code into mRNA has been started. Translation refers to protein synthesis, in which proteins are made by reading the sequence information after the mature and processed mRNA by a ribosome. To me, transcription still refers to transcribing from a recording. But I thought you might want to find out why you're [more...]
Date: 2010-08-05 18:01:00
Obsessed With Genes (Not Jeans), This Teen Analyzes Family DNA ...
The Wests signed up in 2007 and gave 23andMe genetic testing as Christmas presents to family members. From that experience, Mr. West learned that Anne also inherited the mutation on the Factor V gene that increases the risk of a pulmonary embolism. He wanted to know more. By last year, whole genome sequencing was not only being offered to individuals, but the price had dropped enough that Mr. West raised the idea at dinner. "Dad got curious about the whole family," Anne says. Biology has been a passion of hers since the fifth grade. She works at the family computer in a room with a view [more...]
Date: 2010-10-01 18:33:20
Artificial Life Created in a Laboratory for the First Time ...
They manufactured a new chromosome from artificial DNA in a test tube, then transferred it into an empty cell and watched it multiply – the very definition of being alive. The man-made single cell "creature", which is a modified version of one of the simplest bacteria on earth, proves that the technology works. Now Dr Venter believes organism, nicknamed Synthia, will pave the way for more complex creatures that can transform environmental waste into clean fuel, vaccinate against disease and soak up pollution. But his development has also triggered debate over the ethics of "playing [more...]
Date: 2010-05-21 13:46:05
Dienekes' Anthropology Blog: mtDNA of Yemeni and Ethiopian Jews
The way I see it, only a large-scale study of all global Jewish populations may uncover verified ancient Jewish lineages for both Y-chromosomes and mtDNA. The recent studies on Jews have uncovered several genetic sub-clusters of Jews, and only lineages that occur in 2 or more of these clusters, and preferably geographically separated ones have a strong claim of representing original Jewish lineages. There is a limit on what can be uncovered about the past from the study of living populations. American Journal of Physical Anthropology doi: 10.1002/ajpa.21360 Mitochondrial DNA reveals distinct [more...]
Date: 2010-07-14 18:00:00
Al Fin: A Hint of Epigenetics
We are learning that the genetic code is only the short, first chapter in a very long book. The non-genetic "code" -- the non-coding DNA and RNA -- has a logic all its own. We are just beginning to decrypt the obscure cipher. The possibilities for the transformation of life as we know it seem just as grandiose as were the hopes of the early promoters of the human genome enterprise. Only this time, we are working at a deeper level of sophistication. How many more levels will we need to descend before we reach the promised land of genetic medicine? ... some 95 or 98 percent of human DNA was [more...]
Date: 2010-10-13 15:07:00
PLoS ONE: Analysis of Short Tandem Repeats by Parallel DNA Threading
Abstract TopThe majority of studies employing short tandem repeats (STRs) require investigation of several of these genetic markers. As such, we demonstrate the feasibility of the trinucleotide threading (TnT) approach for scalable analysis of STRs. The TnT method represents a parallel amplification alternative that addresses the obstacles associated with multiplex PCR. In this study, analysis of the STR fragments was performed with capillary gel electrophoresis; however, it should be possible to combine our approach with the massive 454 sequencing platform to considerably increase the [more...]
Date: 2009-11-13 08:00:00
Evolution News & Views: "Junk" DNA: Darwinism's Last Stand?
In 1980, Francis Crick and Leslie Orgel argued in Nature that "much DNA in higher organisms is little better than junk." The spread of junk DNA in the course of evolution "can be compared to the spread of a not-too-harmful parasite within its host." Since it is unlikely that such DNA has a function, "it would be folly in such cases to hunt obsessively for one." In a companion article, W. Ford Doolittle and Carmen Sapienza similarly argued that many organisms contain "DNAs whose only 'function' is survival within genomes," and that "the search for other explanations may prove, if not [more...]
Date: 2009-06-04 16:00:00
Genetic fingerprint | Courtesy, This, There, Some | Knowledge ...
DNA is composed of a chain of sequences consisting of the four bases , A, T, C, and G. Some of these sequences code for the manufacture of proteins : they are called genes . There are other sequences of DNA that do not code for any proteins. A number of these latter sequences are specific to each individual and, therefore, constitute a genetic signature. This signature is called a genetic fingerprint. Courtesy : http://www.cite-sciences.fr/lexique/definition1.php?idmot=54&rech_lettre=g&num_page=5&habillage=glp&lang=an&id_expo=2&id_habillage=64 Tags: genetic This entry was posted on [more...]
Date: 2010-10-06 18:25:08
UC Davis News & Information :: Brain Gene Shows Dramatic ...
In a computer-based search for pieces of DNA that have undergone the most change since the ancestors of humans and chimps diverged, "Human Accelerated Region 1" or HAR1, was a clear standout, said lead author Katie Pollard, assistant professor at the UC Davis Genome Center and the Department of Statistics. "It's evolving incredibly rapidly," Pollard said. "It's really an extreme case." As a postdoctoral researcher in the lab of David Haussler at UC Santa Cruz, Pollard first scanned the chimpanzee genome for stretches of DNA that were highly similar between chimpanzees, mice and rats. Then [more...]
Date: 2006-08-16 07:00:00
DNA: The Tree of Life ( Humanity Hacking Immortality )
Visit my website http Seek Knowledge for "Life" Music by korn (Evolution) Visit my blog key-universe.blogspot.com DNA en.wikipedia.org Nucleic acid en.wikipedia.org Genetics en.wikipedia.org Protein en.wikipedia.org RNA en.wikipedia.org Polymer en.wikipedia.org Nucleotide en.wikipedia.org Nucleobase en.wikipedia.org Genetic code en.wikipedia.org Amino acid en.wikipedia.org Chromosome en.wikipedia.org DNA replication en.wikipedia.org Eukaryote en.wikipedia.org Helix en.wikipedia.org DNA sequencing en.wikipedia.org Junk DNA en.wikipedia.org Triple-stranded DNA en.wikipedia.org History of [more...]
Date: 2010-08-27 22:27:16
Scientists Create First Living Synthetic Cell With Computer, Mix ...
TORONTO – In revolutionary research that may end up altering our definition of life, scientists have created the first synthetic cell powered by artificially created DNA. The achievement caps 15 years of work by a large team of researchers, led by Craig Venter of Human Genome Project fame, who engineered a chromosome and inserted it into a bacterium to create a new living entity. ``This is the first self-replicating species that we've had on the planet whose parent is a computer,'' Venter told a teleconference presented Thursday by the journal Science, which published the work. The [more...]
Date: 2010-05-21 14:21:11
Evolution News & Views: Guy Walks Into a Bar and Thinks He's a ...
Part of the reason for this is if one decides to take into account the plethora of species-specific DNA insertions and deletions ("indels") that are present along any segment compared between chimp and human, the percentage of identity drops. Another reason is that duplications, inversions, translocations, and transpositions at all scales uniquely characterize the two genome sequences -- these have to be untangled before aligning the sequences in order to measure their similarity. Also, the 99% identity figure is often derived from protein-coding regions that only comprise about 1.5% of the [more...]
Date: 2009-05-14 19:06:54


text:
Our Menus
Please see below our current menus
We also offer daily changing specials Monday - Saturday see sample menu here
Our Chef has created imaginative and creative menus for you to savour. From our sophisticated a la carte menu to our relaxed Daytime Bites Menu, we have something available for everyone. On Sundays we offer a traditional roast menu, our menu changes weekly (view a Sample Sunday Roast Menu)
The Bar & Terrace Menu offers everything from Light Bites to Scones with Cream and Jam something for a lighter, relaxed meal and is served Monday - Saturday from 12pm until 6pm.
Afternoon Tea, Morning Coffee and Pastries and Breakfast are also available
Private Dining is available in our Granary Area of the Restaurant
In line with our environmental policy the restaurant uses fresh, seasonal, locally sourced produce wherever possible, including vegetables and herbs grown on-site, and Trout which is farmed and caught in the grounds of Tewin Bury Farm.
Please mention any food allergies or special requirements at time of booking.
All beverages used in our restaurant are Fair Trade accredited.

subset: commoncrawl


text:
Miss Pinky mentioned this place the other day, and I realised that these guys follow me on Twitter, and I haven't made the effort to go and try them out. Well now I am, and this time I'm going to go with Miss Pinky and her new boyfriend who I am still stuck trying to give him a nickname. He looked offended when I suggested one name! (Yes, the new boyfriend knows I blog too!)... So I think I will call him Mr Picky, as he is apparently picky with food. (He might not appreciate this but I like it). (^_^)v Good thinking Geek!
I got there early and was sitting and waiting for them, plus passed a level in Candy Crush... It does start getting easy-ish by the way. Just have to work on your gaming skills.
Before I came here I had looked on the website beforehand just to see what the pancakes, desserts and savoury foods were like. They all sound great, but I wish there were pictures I could see. On the pancake section you can hover over the item and you can see a picture... That's not really a good design feature by the way, because it doesn't work properly on Google Chrome...
|Outside My Old Dutch
My Old Dutch in Holborn is very close to the station so you won't get lost at all. As we stepped in we got seated straight away...
|Sorry for fuzzy picture... The inside
We all needed time to decide what to eat because we haven't had a savoury pancake for a bit, and I have never been to My Old Dutch before. In the end this is what we had...
|Compote of Berries pancake with ice cream
I had the Banana, Nuts, Cream and Chocolate sauce Waffles. This tasted really good! However the cream melted too quickly (I wasn't quick enough to eat it!) and it wasn't filling... :( They should've put an extra waffle in for me!!
|Banana, Nuts,Cream and Chocolate Sauce Waffle
Miss Pinky had the Lamb Stew pancake... Interesting! This one tasted really good, and I just thought why didn't I order a savoury pancake in the first place?!
|Lamb Stew Pancake
After eating my waffles, I still felt hungry. I wanted a proper pancake... A Dutch pancake! :P And Miss Pinky wanted something sweet.... So we had this. Mr Picky was already full from what he had, so he didn't order anything else.
Miss Pinky decided to order a You Choose your own. It was basically the same as what Mr Picky had... ¬,¬"" Oh dear... she didn't finish it. It was way too big!
|Miss Pinky's pancake
And I had this... The My Old Dutch pancake. This was very filling, but I didn't attempt to finish it. I think I would have without the presence of Miss Pinky and Mr Picky!! It was almost like looking at a thin crust pizza heheheh...
|My Old Dutch pancake
Total cost came to £60 something... Expensive!!! Mine was about £16 worth not including the beer I had. If I need to come for dessert after a long day I think I would come here. It was a very peaceful restaurant for a Sunday!
My geeky rating: 4.5/5 (giving to a lot of places recently!!)
Good points:
- Massive pancakes both sweet or savoury
- Ok prices
- Good, spacious seating area
Bad points:
- Waffles didn't fill me up... and that's about it!
Address: 131-132 High Holborn, Holborn, London WC1V 6PS
Telephone: 020 7242 5200
Telephone: 020 7242 5200
Website: http://www.myolddutch.com/


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drake - black
We're sorry, this shoe is out of stock. Try another colour or, if your heart is set on this style, join our WAITLIST HERE and We will notify you if this product becomes available.
The 'Drake' unstructured bootie is an ultra wearable flat, crafted from supple black suede leather - a perfect everyday Winter neutral. First developed in Italy in the 1950s, this low ankle-skimming 'glove' style bootie ties at the front to create a small lace-up keyhole while the soft unstructured construction makes the 'Drake' accommodating for every fit. Includes cushioned mid-sole with breathable kid leather lining, full Italian kid leather uppers and leather sole. Italian made shoes.
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We happily accept returns on full priced items ordered from our web store within 14 days. If you are in any way unhappy with your goods you may send them back for an exchange, credit note or refund. All items must be unused and in original condition with original packaging. Please note all footwear must have original, undamaged shoeboxes with no sole markings or scratches.
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European Sizing. 35-42. B fitting. Fits true to size and unstructured nature suits all foot shapes. Heel height: 20mm. Click here to view size grid.
We do recommend applying a suitable 'protector' spray to the suede areas every 4-5 wears. Click here for more care info.


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Central Arkansas Christian's Lady Mustang golf team competed for its first team title in a district tournament Tuesday in the 7-4A District Tournament at Nashville Country Club.
The top two teams qualified for the Class 4A State Tournament, which will be at Thunder Bayou in Blytheville on Wednesday, Oct. 2.
Ashdown is the defending district champion, but the Lady Mustangs, though young, were the favorites in the district tournament.
"In district we've only seen Arkansas Baptist and Malvern," Lady Mustang coach Max Weiner said Monday. "Both are capable of doing well, but with golf, you never know. We haven't seen half the schools in our district play this season, so someone could show up and surprise us."
In Class 4A competition, teams play four golfers and count the best three. The CAC lineup included freshman Allie Weiner and sophomores Alexa Goodlow, Lauren Horton and Cheyenne Butler.
"Allie is playing very well right now," the coach said Monday. "In our nine-hole matches, she's averaging two- or three-over par. Alexa, the defending district medalist who made all-state last year, is also a very strong player and has had a low round of 81 this season at the North Little Rock tournament. Lauren Horton shot a 40 for nine holes the other day at Stonelinks, and Cheyenne Butler has made a huge improvement over the last few months."
Valley View, the defending state champion, has two seniors, both of whom will play Division I golf next year, Weiner said.
"I'm hopeful we do well at district and then head to Blytheville next week and give Valley View a run for their money," he said.
CAC has never won a state girls team title in golf.


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The bout Fujioka will see Fujioka moving down from Flyweight to Light Flyweight, whilst Valle will be moving up from Atomweight to Light Flyweight for the bout. If the experienced Fujioka wins she will create history by becoming the first Japanese fighter, male or female, to be crowned a 5-weight boxing world champion.
The show will also feature several other bouts of note, making it yet another A-Sign card worth some serious attention.
One of those bouts will see Kosuke Saka (16-3, 13) [坂晃典] defending the Japanese Featherweight title against Takenori Ohashi (14-4-2, 9) [大橋健典], in what will be Saka's first defense of the titlethat he won earlier this year against Shota Hayashi. Whilst another notable bout will see the heavy handed Keita Kurihara (9-5, 8) [栗原慶太] take on world ranked Filipino Ryan Lumacad (13-0-3, 7) in what should be an explosive encounter.
(Image courtesy of boxingnews.jp)


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WHILE some weddings are as quiet in spirit as an Edward Hopper painting, Brett Savage and Ryan Baker's wedding was like a parade, Super Bowl celebration, light show, disco party and black-tie dinner all at once.
Everything about the wedding was oversize, beginning with the invitations, which were so large that they could have been used to mark the bases in a softball game.
The couple, who love cities, jokes, sports and nice shoes, met two years ago in central Illinois. Both were working as anchors at small television stations, Mr. Baker at WCIA in Champaign and Ms. Savage at WICS in Springfield.
"There was nothing to do in Springfield," said Ms. Savage, who is 28 and grew up in New Rochelle, N.Y. "And I mean nothing. I was surrounded by cornfields."
Mr. Baker, 25, also had an empty social calendar until he saw Ms. Savage on television. "I thought, 'Wow, that's a fine-looking sister for central Illinois,' " remembered Mr. Baker, who grew up in Chicago. As soon as he could get up the courage, he called and asked her out on a date -- lunch in a nearly deserted diner in Springfield.Continue reading the main story
A year later, when they became engaged, they swore that their wedding would be no quiet ceremony in a cornfield. The bride quit her job last summer to begin planning an extravaganza that included everything from a light show to a four-foot-tall wedding cake.
On July 1, they were married at St. Catherine A.M.E. Zion Church in New Rochelle. Afterward, the couple and their wedding party traveled in a fleet of eight honking limousines to the Pierre Hotel in Manhattan. Motoring down East 61st Street, they looked like a school of great white sharks.
As they rode, the bride and the bridegroom stood together in the open sunroof of their car. Mr. Baker, now a sports anchor at WCPX-TV in Orlando, Fla., wore sunglasses and waved a foaming champagne bottle; the bride's veil flew in the wind like a flag on a speedboat.
"People on the sidewalks were screaming and clapping," said Rob Baker, a brother of the bridegroom and a groomsman. "It was like we'd won the world championships."
Inside the Pierre, drinks and shrimp as large as ankle weights were served in a room with paintings of formal English gardens on the walls. While the atmosphere was staid, the spirit was not, especially when everyone was invited to enter the ballroom for dinner.
It was like walking into a hot new nightclub, as if a ticket or a special hand stamp should be required. In the nearly dark ballroom, bright purple spotlights lighted the bride and the bridegroom's table while the wedding party's table, right behind it, was colored with pink lights and glowed like a sunset.
After the 250 guests were seated, the bridesmaids and the groomsmen were introduced like contestants in a beauty pageant, to disco music and spotlights. Just before the newlyweds appeared, the entrance filled with smoke, and they burst through it as if they were two people in a music video.
"What a night!" exclaimed Ruth Carter, a guest. "It was exquisite, funky and soulful. I don't think the Pierre has ever seen anything like it. You normally see those things at a discotheque or an extravaganza show with Michael Jackson. People got down. I saw someone with a cane -- they couldn't dance but they were shaking the cane."
The bridegroom was so jubilant during the reception that he was seen somersaulting on the dance floor at one point. Speaking from a bridal suite at the Pierre the next day, he recalled what it felt like to enter the ballroom through clouds of smoke.
"It was like a dream," he said. "It was surreal. In life, you don't have to search for bad things -- they find you without a problem. Disasters always seem to know your address, even if you move. But the good times, they're hard to find, and this one was one of those truly spectacular times."Continue reading the main story


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The Mentalist (2008)
11 pictures
Starring: Owain Yeoman, Robin Tunney, Simon Baker, Tim Kang
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Sun readers discuss military action in Syria, the woman who talked down a school shooter, the Florida Gator band, and other topics.
Unethical conduct
The Sun's Aug. 14 editorial about Beth LeClear was disheartening. It is sad when our leaders, especially educational leaders, engage in unethical conduct. It is also sad when the superintendent endorses questionable activities.
I wonder why the School Board has not investigated this matter. Maybe the attorney general should be involved.
Anthony Holland,
Same game plan
University Avenue and 13th Street are silent. The Plaza of the Americas is empty. There are no crosses on Northwest Eighth Avenue. Where in the world are all the anti-war, no-blood-for-oil types these days? Obviously they're at home or something, sitting on their hands as we march toward another war.
There is no United Nations resolution to fight a Baathist dictator who uses chemical weapons and slaughters his own people, yet we march toward war. Once again the shameless progressives who were so vocal when we went to war against Saddam are now silent as their president is following the exact same game plan as the dreaded evil Bush.
I guess it's all OK as long as the bombs, cruise missiles and combat boots have "Ds" painted on them. I always wondered why the Democrat party chose its logo. Now I know.
John Annarumma,
Amazing woman
Wayne Lapierre famously said "The only way to stop a bad guy with a gun is a good guy with a gun." Antoinette Tuffs, who talked down a potential school shooter, proved him wrong.
A better way to stop a bad guy with a gun is a good person with a brain and a heart. She couldn't have done better if she'd been a trained crisis counselor. What an amazing woman!
Kingsli Phillips,
Hard work
I just wanted to mention the University of Florida marching band and how dedicated its members are to entertain the fans at each game. The band directors are outstanding and do a wonderful job preparing the students for each show. It is a shame that the news does not recognize them for all their hard work and dedication.
They have practiced for weeks for about 12 hours a day, working in the blazing heat so they can be prepared to entertain Florida fans. I would like to give a shout out to the Gator band. Go Gators.
Cindy Amster,
Safe corridor
I have both ridden my bicycle and driven my car on the Northwest Eighth Avenue reconfiguration from my home. I have found the experience to be enjoyable, timely and safe.
While on my bicycle I have seen many others enjoying and using the new space along the side of the road to get to class, work and exercise. While in my car I have experienced a safe and timely commute towards the mall and the 34th Street corridor.
I want to thank the City Commission for helping make Eighth Avenue a safe and viable corridor for all road users, regardless of mode of transportation.
Tim Hayes,


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Court ruling backs webcam abortion ban
By JOANNE FOX, Globe editor
DES MOINES – A Polk County District Court judge ruled Aug. 19 in favor of the Iowa Board of Medicine's ban on webcam abortions.
Judge Jeffrey Farrell said Iowa regulators were within their rights when they voted to ban a first-in-the-nation, videoconferencing system that let physicians dispense abortion drugs to women in rural clinics.
Bishop Walker Nickless of Sioux City called the ruling, "a small, and yet, very important victory for the culture of life."
"The intentional killing of innocent human life, including webcam abortions, is always deplorable and intrinsically evil," he said. "No matter the intentions and circumstances, abortion always harms the lives of the mother and baby."
Bishop Nickless expressed his pleasure that Judge Farrell "saw the importance of insuring the health and safety of both the mother and baby."
"I attribute this victory to many the prayers of the people offered to our Lord and our Blessed Mother for an end to abortion and to the tireless work of the prolife advocates," he noted. "Along with today's ruling, we continue to see glimmers of hope, such as the closing of Planned Parenthood clinics in Storm Lake in 2012 and in Fort Dodge in 2013. We must persevere in offering prayers and support to build a culture of life, as this ruling provides more momentum for us all."
Webcam abortions
Last year, the Iowa Board of Medicine voted to adopt and file ARC 1034C to establish standards of practice for physicians who prescribe or administer abortion-inducing drugs to terminate a pregnancy via videoconferencing.
In a "webcam" abortion, a doctor first discusses the procedure via closed-circuit video with the patient. If the physician agrees it is appropriate for the woman to abort, the doctor enters a computer code that opens a drawer with the abortifacient drugs. The woman ingests the first pill while the doctor watches, then goes home, takes the remaining pills and waits for the abortion to take place.
"Women can die when life-ending drugs are carelessly administered," said Dr. Charmaine Yoest, president and CEO of Americans United for Life, headquartered in Washington, D.C. "Iowa's regulation and today's decision demonstrate that doctors agree that chemical abortion can be dangerous for women and requires a careful examination. Providing these drugs without a physical examination by a physician amounts to nothing less than reckless gambling with the lives of women."
The Iowa Board of Medicine voted 8-2 in 2013 to adopt language which would require doctors to be physically present when dispensing abortion pills and to provide follow-up exams.
The board stated at the time that "the goal of the new rule is to protect the health and safety of Iowans."
"The Board believes that all patients, including those in rural Iowa, deserve the highest level of care," the board stated. "The Board believes that a physician must establish an appropriate physician-patient relationship prior to the provision of a medical abortion. The physician's in-person medical interview and physical examination of the patient are essential to establishing that relationship."
Suit filed
Planned Parenthood of the Heartland, Des Moines, had sued the board, arguing its decision to not allow doctors the use of the video conferencing system would limit rural women's access to abortions. The agency began using the practice in 2008.
Iowa Right to Life alerted the public on webcam abortion when the practice was implemented.
"Over the last six years, we have worked tirelessly to educate Iowans about this dangerous practice that risks the health of women all over Iowa," said Jennifer Bowen, executive director of Iowa Right to Life.
"We welcome today's ruling by Judge Farrell in which he rules in favor of the Iowa Board of Medicine's decision to ban the dangerous practice of webcam abortion in the State of Iowa," she added. "While the plaintiffs have vowed to appeal this common-sense decision, we know, having reviewed the Iowa Board of Medicine's rationale behind the rule at question in the case and after hearing from women who have suffered complications and negative effects of the procedure, a ban on the practice was the only logical outcome in this case."
In his decision, Judge Farrell said the medical board has the authority to regulate this medical practice.
"There is no question that the board has the power to establish standards of practice for the medical profession," he said. "Those standards include the authority to adopt and enforce standards regarding the minimal standards of acceptable and prevailing practice."
Decision to be appealed
The system has remained in place during this time. The judge's ruling is set to take effect in 30 days. Planned Parenthood will appeal the ruling.
"While the board of medicine claims it is acting to protect women's safety and health, its true purpose is to prevent women from receiving an abortion if and when they need one. And the rule would actually jeopardize women's health by delaying their care," Penny Dickey, the agency's chief operating officer, said in a prepared statement. "Planned Parenthood of the Heartland will continue to fight for evidence-based medicine and a woman's right to make her personal health care decisions."
Tom Chapman, director of the Iowa Catholic Conference noted there was "ample" evidence presented leading up to the board's vote questioning whether providing a chemical abortion following a consultation only by videoconference was good medical practice.
"In every case, the drugs that cause a chemical abortion have serious effects," he pointed out. "If abortions are to take place, the safety and informed consent for the women involved should be among our chief concerns."
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The Licensing Information page was designed to give contractors and consumers easy access to the state regulatory agencies information. NASCLA has provided you direct access to the state's regulatory agency's website in order to access contact information, forms, applications and much more.
8/27/2018 » 8/30/2018
NASCLA 2018 Annual Conference
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SOURCE: BSH Bosch und Siemens Hausgerate GmbH
April 08, 2014 13:21 ET
Strategy for Accelerated Profitable Growth Introduced
Substantial Investments in Regional Presence, Innovation Power and Brands
Goal: Outperforming Market Growth and Expanding Global Market Position
Strategy for Accelerated Profitable Growth Introduced
Substantial Investments in Regional Presence, Innovation Power and Brands
Goal: Outperforming Market Growth and Expanding Global Market Position
MUNICH, GERMANY--(Marketwired - Apr 8, 2014) - BSH Bosch und Siemens Hausgeräte GmbH (BSH) raised its total revenue by more than 7% to EUR 10.5 billion according to the preliminary 2013 figures disclosed today. Double-digit growth in China and the USA, combined with the company's success in extending its market leadership in Europe, contributed to this record-setting revenue. With this performance, BSH has secured its position as the global no. 3 among household appliance manufacturers. EBIT topped EUR 500 million despite the costs of a voluntary safety measure for dishwashers. From this position of strength, BSH aligns its strategy toward long-term profitable growth, and will invest substantially in innovative products and the global implementation of its multi-brand strategy.
"We have reached an important milestone in our company's history with more than EUR 10 billion consolidated revenue, and are now poised at an excellent vantage point, poised for future international growth," says Dr. Karsten Ottenberg, CEO of BSH. R&D intensity remained high in 2013 at more than 3% of revenue while the headcount increased to around 50,000. A Euro bond issue in excess of EUR 500 million contributed to the company's long-term liquidity. "BSH is looking back on an extraordinary success story and we are to continue this story. We intend to extend our position on the global market and outpace the market with profitable growth," notes Ottenberg.
BSH's CEO states the firm will have to identify the challenges in diverse international markets for household appliances and consistently seize regional opportunities to achieve this target. BSH aims to maintain profitable growth in the years ahead by pursuing a strategy focused on the diversity of consumers' needs. The emphasis will be on expanding regional competencies as well as on investing in the firm's innovation capabilities, in the product portfolio and in the brands. Ottenberg adds "Our strategy builds on what made BSH strong and made us stand out: globally renowned brands, the experience and expertise of our people, and our proven technology skills." In the future, the prevailing technology in household appliances is to be combined with digital functions and design features.
Digitalization and regionalization -- crucial for success
"Consumer behavior is changing, and regional growth markets are shifting. The impact of digitalization on products and the value chain is playing an ever more prominent role in all this." Ottenberg adds, "We will be aligning our offer accordingly, and persistently taking advantage of and actively shaping the changes in the market. All along our value chain, from product development to marketing and service, we are redoubling the focus on consumers' needs and offering a solution to fit each need." As BSH's CEO sees it, regionalization will be the key to the company's future success.
Based on a solid financial position, BSH also aims to invest a high triple-digit million amount in R&D, in expanding its presence in the regions, and in its brands. Apart from Europe and China, the focus will be on North America, Turkey, Russia, the Middle East and Africa, as well as on Asia Pacific markets, including India and Southeast Asia.
The final figures for fiscal 2013 will be published in late May 2014 with the annual report.
Press photos are available at presse.bsh-group.de.
With annual sales of around EUR 10.5 billion in 2013 and more than 50,000 employees, BSH Bosch und Siemens Hausgeräte GmbH is one of the global leaders in the home appliance sector. BSH manufactures at 40 factories, operates over 80 companies and has a presence in 47 countries.
For more information, visit www.bsh-group.de.
Contact:BSH Bosch und Siemens Hausgerate GmbH
Corporate Communications
Fridolin Weindl
Tel.: +49 (0)89 4590-3391
E-Mail: firstname.lastname@example.com
Contact:BSH Bosch und Siemens Hausgerate GmbH
Corporate Communications
Fridolin Weindl
Tel.: +49 (0)89 4590-3391
E-Mail: email@example.com
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Focus Standards & Skills
Standard RL.9.2. – I can determine a theme or central idea of a text. I can analyze, in detail, the development of the theme, including how it emerges and is shaped and refined by specific details.
Standard W.9.4. - I can produce clear and coherent writing in which the development, organization, and style are appropriate to the task, purpose, and audience.
Standard W.9.2. - I can write informative/explanatory texts to examine and convey complex ideas and concept. I convey my explanation(s) clearly and accurately by selecting relevant supporting details, organizing my information, and analyzing my evidence in relation to the concept I am discussing.
Of Mice & Men - Themes as Symbols
M&M symbols
Class Handouts
Class Handouts
Of Mice & Men
Subpages (1): Of Mice & Men - Theme


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In a cockpit, functionality and comfort are key. This PME 333 Henley is inspired by traditional underwear, worn by the cargo pilots of yesteryear.The garment is constructed with a comfortable yet functional waffle or honeycomb fabric, woven with a special technique that makes it both very absorbent and quick drying.
100% Cotton
To choose the perfect size for you PME Legend blazer, it is the best option to measure up your own shoulder or chest width. You can also grab a T-shirt you already own and like. Sizes of different brands can vary, so it is always handy to measure your size instead of sticking to L or XXL. In doubt which size to choose? Pick the smaller one for a more slim look and the bigger size for a more relaxed and loose fit. Still in doubt? Just give our customer service team a call, we are happy to help you out.
Measure your full chest on the widest part below your armpit.
Measure the shoulder seam on the backside of your T-Shirts from one side to another.
Shipping costs are for free. Your order will be delivered within 2 working days and will be shipped by our reliable partner DHL.
You can easily return your order for free via a DHL Parcel shop. Find more detailed information about returns in our FAQ.
We accept numerous payment methods: iDeal, PayPal, VISA and Mastercard. All of our payments are secured by a Secure connection guaranteed by Comodo.
Our webshop service team is here to help you, we are open on Monday – Friday from 08:00 - 22:00 and on Saturday and Sunday from 09.00 - 21.00hrs. You can contact our team via phone +31 (0)88 05 30 550 or send an e-mail:


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Our youth advisor program is for anyone under 26 years old. Youth advisors help us in a number of ways. They can advise on what "big-picture" issues our office reviews. They can give us their opinions on these issues. They can help us work with other youth in their communities.
If you are interested in getting involved, please email us at firstname.lastname@example.com. Make sure to include the following information:
We look forward to hearing from you!


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The Irvies would not be possible or complete without the valued support of our wonderful sponsors. With four levels of sponsorship (Bronze, Silver, Gold, and Platinum), the following partners below are integral to the planning, promotion, and success of this event. Click HERE to download our sponsorship packet to learn more about opportunities, ROI, and putting a package together.
Hampton Designs
Irvington Jewelers
Tyner Pond Market
Ace Central Hardware
Lincoln Square Pancake House
The Mug
10 Johnson Avenue
Dairy Queen
Audrey's Place
Deering Cleaners
Simply Divine Cupcakes


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Words that end in agagh
Found 1 words that end in agagh. Browse our Scrabble Word Finder, Words With Friends cheat dictionary, and WordHub word solver to find words that end with agagh. Or use our Unscramble word solver to find your best possible play! Related: Words containing agagh
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Teacher for american nursery required!!!! (Kuwait City)
Dear American / European lady, if you are looking for a part time job and you love children, please contact me asap! A nursery between 1st and 2nd ringroad is looking for a teacher; very good pay, great team and wonderful babies are waiting for you!!!


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A new video has been launched to help people suffering from back pain in Birmingham.
The Heart of England NHS Foundation Trust has created a new animation which it hopes will reduce the need for hospital treatment at its Heartlands, Solihull and Good Hope sites.
The video is designed to show people some of the basic things they can do to aid their own recovery from back problems.
Julie Hunter, the trust's therapy lead for planned care acute and community services, said: "Evidence has shown that if we can encourage people with acute back pain to keep moving it will usually resolve within six weeks, unless there are other underlying factors.
"Keeping active can speed up recovery but if you don't and resort to something like bed rest instead you could have further trouble and more pain.
"It is simple advice but that education needs to get out there and that is why we have put this animation together.
"The more patients who take note of these messages the better their recovery will be and the less likely they will need to come into hospital."


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Potassium sulfate: 54% of the theoretical, generally 50%; is a chemical neutral, physiological acid fertilizer, has a good water-soluble, but long-term use, will increase the soil acidification, suitable for grape coloring to fruit ripening, Promote the fruit powder coloring, increase fruit sweetness.
Application of potassium sulfate in different soil reactions and should pay attention to matters:
(1) in the acidic soil, the excess sulfate will increase the acidity of the soil, and even increase the soil active aluminum, iron poisoning crops. In the flooding conditions, Potassium Sulphate too much sulfate will be reduced to generate hydrogen sulfide, so that the root damage black. Therefore, the long-term use of potassium sulfate and farm manure, alkaline phosphate and lime with the reduction of acidity, in practice should also be combined with drainage measures to improve ventilation.
(2) in the calcareous soil, sulfate and soil calcium ions in the soil is not easy to dissolve calcium sulfate.
(3) focus on the use of avoid chlorine crops, such as tobacco, tea, grapes, sugar cane, beet, watermelon, potato and other potash increase not only yield, but also improve the quality. Potassium Sulphate Potassium sulfate price is more expensive than potassium chloride, less supply, should focus on the use of chlorine sensitive and hi hi potassium on the economic crops, the benefits will be better.
(4) potassium sulfate should not be mixed with calcium-rich fertilizer application.
It is said that a lot of fruit area of manganese poisoning is caused by soil acidification, and the direct cause of soil acidification is the use of potassium sulfate year round. So, fertilizer, Potassium Sulphate nothing to change with the use, do not have been used, you have been eating something that will cause malnutrition, let alone the land.
Potassium sulfate effect:
Multi-nutrient, significant increase in production. And contains trace elements such as sulfur, iron, zinc, molybdenum, magnesium and other crops. At the same time, the product has the characteristics of uniform color, stable quality, good solubility and easy to be absorbed by crops. After application, Potassium Sulphate it can change the common Nutrient imbalance of the situation, compared with other production of compound fertilizer, with a fast absorption, loss of small, long-lasting fertilizer, yield significantly and so on.
Wide range of adaptation. The product has high active ingredient content and less than 3% chloride. The product is not only suitable for various crops such as wheat, rice, corn and peanut, Potassium Sulphate but also for fruit crops such as fruit trees, vegetables, tobacco, garlic and ginger. Do base fertilizer can be used for top dressing.
Improve soil, enhance soil fertility. The product is non-toxic side effects on the crop and soil and does not produce any adverse effects, after application, can quickly add the soil potassium, zinc, Potassium Sulphate boron and other elements, adjust the soil structure, enhance national strength, and drought resistance, lodging Long-term use can improve the soil, improve production.


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A series of Landscape (BW)
I love shooting landscape. Sometime landscape isn't just about colors! Some interesting landscape can be created by emphasizing contrast, and strong contrast can be produce by black and white image.
This Picture is taken just outside Likir Monastery, Ladakh. Using slow shutter speed to capture water movement. In the background is Himalayan mountain range on summer. Hot and fresh!
The Taj Mahal. Captured from across Yamuna river. An overcast afternoon at Agra, India.
A shot from top of hill where Stok Palace lies, Ladakh. Afternoon sun light coming from left, creating a fascinating contour on the mountain. It add some texture on it.
I just like the contrast of this shot. Very dark foreground combining with brighter background which is nice. A snap shot during my way to Alchi Monastery, Ladakh. Somewhere between Leh and little village of Alchi.
Getting back from Alchi, Ladakh, i found that the mountain texture is very pleasing. Kind of erosion effect look alike. Probably due to the snow or glacier. Just wondering what nature can bring something really beautiful. Shoot from a moving car with average speed.
This one i took at Polonnaruwa, Sri Lanka. What a beautiful ruin! Dying tree in the foreground and palace ruin in the background. A combination effecting on a very strange feeling. Morning sun coming from behind, adding some nice shadow of the tree.
The majestic Thiksey monastery. Another sample of Ladakh structure. Love the leading line created by the small tree, directing the eye to the hill monastery. Taken at midday. Hot and breezy.
Open blue sky, white cloud, hard wind. Shoot from top of Thiksey monastery, Ladakh.
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May 29, 2007
50 (First) Dates
Posted in: Life & Culture
Here are some ideas from my limited experience to help you meet, seduce, and hopefully-not-but-maybe-because-people-sometimes-grow-apart-and-that's-just-a-fact-of-life-okay? dump that special someone. Some people will carry out entire relationships over the course of doing problem sets together. That's cool, but for the adventurous type, here are additional suggestions:
Meet and greet -- spots on campus
18.03 recitation (but don't date your TA until after grades are in)
Barker Reading Room
Campus Preview Weekend
Career Fair -- alums come back and recruit for their employers; everyone looks better with a reversed brass rat and ironed shirt
Killian Court
Lecture Series Committee
MIT Museum -- what's more romantic than holography and free entry with MIT ID?
Music practice rooms -- serenade your special someone in a locking (!) piano room
Steam Cafe -- no, it's not a sauna or spa
Z Center -- the only place in the winter where I've consistently found skimpily dressed people; if you know of others, do share
Let's take this slow -- first date places
Athena cluster -- teach him/her about George Washington
Chilli Duck -- "if it's not working at Chilli Duck, it's not going to work" says Sam '07
Club Passim -- live music
Grendel's Den -- the turkey & havarti sandwich just might change your life
Middle East Restaurant & Club
Senior Ball -- pop quiz: which blogger inspired this one?
Star Market -- if you can't grocery shop with this person, you probably shouldn't marry him/her... and that is exactly what you should be thinking about on your first date
Toscanini's -- because I have a free ice cream coupon that I need to use soon
Out in Boston
Bank of America Pavillion -- I have been here exactly twice, junior year for a Clay Aiken concert and last Friday for a Keane concert; I am still deciding which rocked the house more
Black Ink in Beacon Hill -- where we found greeting card gems like this and this
Boston Common & Public Gardens
Boston Public Library
Boston Symphony Orchestra
Red Sox game
Mapparium at the Mary Baker Eddy Library
Mike's Pastry in the North End
Museum of Fine Arts
Wang Center -- I took someone here to see Jon Stewart perform, and I have yet to top it
Yum yum -- romantic dining
Aujourd'hui -- at the top of my list (and not just because it's alphabetical)
Enormous Room -- small platters, lounge atmosphere
Flour bakery -- high quality pastries, sandwiches are good too
L'Espalier -- French food, wine Mondays & cheese Tuesdays
Lala Rokh -- Persian food in Beacon Hill
Meritage -- amazing seafood, views of the harbor
Teuscher -- chocolates on Newbury
Top of the Hub -- views of Cambridge and Boston (food is okay)
Tangierino -- yes, hookah bar and belly dancer too
Go the distance -- far, but worth the trip
Apple picking in Nashoba
Ben & Jerry's factory in Vermont -- the Cabot factory has unlimited cheese samples, but Ben & Jerry's is easier to get to
Cape Cod -- or so I hear, I've never been; ask me in a week =)
Coolidge Corner Theater -- "the Boston area's only non-profit independent movie house"
Franklin Park Zoo
MIT Outing Club Cabin
New York City
It's not you, it's me -- best places to break up
Commencement -- if not now, then when?
Duck Tour -- all that quacking will drown out the sobs
Front desk of your dorm -- it's not so hard to find the way out from here
Park Street subway stop -- at the crossroads of the red line, the green line, and your future together
The Tech -- pop quiz: who did this? and are they back together? and if so, WHY???
TechTV video
(Of course, you can do many of these things by yourself, with friends, or with family)
Comments (Closed after 30 days to reduce spam)
Posted by: yg'11 on May 29, 2007
Lovely post.
Posted by: Viksit on May 29, 2007
Posted by: Sam on May 29, 2007
Posted by: 0 on May 29, 2007
Posted by: Mitra on May 29, 2007
Posted by: Sam on May 29, 2007
Posted by: Anonymous on May 29, 2007
I mean, Adam proposed in Killian in front of an Asian tour group (very stereotypically MIT), and I know you had that friend who proposed in Lobby 7. There have to be some more good proposal places.
Posted by: Mollie on May 29, 2007
Posted by: Hank R. on May 29, 2007
But seriously, all chocolate lovers must go to Teuscher. I still have a couple of bars left in my fridge.
Posted by: milena '11 on May 29, 2007
Posted by: Yuri on May 29, 2007
Posted by: Yuri on May 29, 2007
Posted by: Yuri on May 29, 2007
Posted by: 0 on May 29, 2007
Posted by: Timur on May 30, 2007
I've been trying for the past 5 hours, to access a post on one of the blogs by either Sam or Bryan (not Nance). I can't remember exactly who posted it and the date of post. But the topic is one the number 1024, the power of 2, how to know an MIT or the formula to gain admission into MIT.
I was so busy thinking about how to prove it that I forgot to take note of whose blog it was, and the date of post. I do know however that it was posted long ago. Now, I've got the proofs and I need to refer to it.
Posted by: Omorx on May 30, 2007
Omorx, It was Sam's entry, here: http://www.mitadmissions.org/topics/life/student_life_culture/power_of_suggestion.shtml
Posted by: Mitra on May 30, 2007
You were so fast in getting it.
That is the power of MIT.
Posted by: Omorx on May 30, 2007
This is what puzzled me two days ago as I thought hard about it, after reading it from Sam's blog. Although I was quick to recognize that it is really, but as a mathematician and a scientist, I need not believe things simply because somebody else said it no matter how noble or reputable the person is. (Remember what happened during Galiloe days when he said the world was flat and people believed him.) So I took it upon myself to prove that MIT is really a power of 2.
After 2 days, I was able to do it. And just 2 hours ago I started typing it. In the next 2 minutes, I would be 2ru with it and post it just 2 seconds to my alarm clock that is set to ring at 2. I'm beginning to write like Jess Kim.
Proof 1: The "Comparison" proof
Let the word
MASSACHUSETTS which is 13 Letters = x;
INSTITUTE which is 9 Letters = y;
TECHNOLOGY which is 10 Letters = z
But MIT stands for the Massachusetts Institute of Technology
M is the 13th letter of the alphabet
I is the 9th letter of the alphabet
T is the 20th letter of the alphabet.
The fact that Massachusetts Institute of Technology stands for MIT means
x * y * z = MIT
(13letters) * (9 letters) * (10 letters) = 13th * 9th * 20th
Introducing P as the power to be determined,
(13letters) * (9 letters) * (10 letters)* P = 13th * 9th * 20th
Which means:
(13*9*10)letters *P = (13*9*20)th
P = 13*9*20(th)
P = 2 (th/letters)
Hence, MIT is the Power of 2.
Where th/letters is a constant or an SI unit to be named after..who?? no not Omorx. (It can't be me). Sam of-course. It's been his dream. His ultimate life goal.
"My ultimate life goal is to have an SI unit of measurement named after me." That's his words pulled out from his blog.
Proof 2: Add first proof
The word
MASSACHUSETTS has 13 Letters. So M = 13;
INSTITUTE has 9 Letters so I = 9; and
TECHNOLOGY has10 Letters, so T = 10
MIT = MvI*T
= 22*10
If MIT should be a power of 2 and 1024 is a power of 2,
Then MIT should be = 1024 in someway which we should determine
22*10 = 10*24
22*10(vP) = 10*24 (where P is the Power to be determine)
22vP = 10*24
22vP = 24
= 2
Hence, MIT is the Power of 2
1.The operator v is +ve sign
2. 1024 agrees to be permuted only as 10*24 and not 10*2*4 for example.
Proof 3: Subtract first proof
The word
MASSACHUSETTS has 13 Letters. So M = 13;
INSTITUTE has 9 Letters so I = 9;
TECHNOLOGY has10 Letters, so T = 10
= 22*10
If MIT should be a power of 2 and 1024 is a power of 2,
Then MIT should be = 1024 in someway which we should determine
4*10 = 10*24
4*10*P = 10*24 (where P is the Power to be determine)
P = 2 (since 10 up cancels 10 down and 4 up cancels 4 down)
This is if we assume that 1024 is permuted only as 10*2*4
If we decide to permute 1024 as 10*24,
4*10*p = 10*24
And since MIT is 3 letters,
6/3 = 2
So, MIT is a power of 2 in both instances
1.The operator ^ is -ve
2. 1024 agrees to be permuted only as both 10*24 and 10*2*4 only.
Proof No 4: Logical Proof
3 proofs above have shown that MIT is the power of 2. Since MIT is 3 letters making 3 words of Massachusetts Institute of Technology, and 3 proofs show that MIT is a power of 2, then MIT is really a power of 2.
Posted by: Omorx on May 30, 2007
Posted by: milena '11 on May 30, 2007
Posted by: 0 on May 30, 2007
Posted by: Jess on May 30, 2007
Posted by: LOLA on May 31, 2007
Posted by: LOLA on May 31, 2007
Posted by: LOLA on May 31, 2007
Posted by: Mitra's mom on May 31, 2007
Posted by: 0 on May 31, 2007
PS This post was incredibly amusing. Thanks for your insight! (I disagree with the Red Sox suggestion, btw...lol )
Posted by: Kate on May 31, 2007
Posted by: Mom on June 1, 2007
Posted by: Mitra's Boyfriend on June 1, 2007
Posted by: Mitra's Boyfriend on June 1, 2007
Posted by: Muhammad Asim Shehzad on June 1, 2007
The power proof is really great- keep that work going. Truely nice blog. Good luck. MIT is truely a great institution and its students are truely one of the best indeed.
Posted by: 0 on June 1, 2007
The power proof is really great- keep that work going. Truely nice blog. Good luck. MIT is truely a great institution and its students are truely one of the best indeed.
Posted by: vivianne on June 1, 2007
Comments have been closed.


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Meet the Maker: Laura Smith
Glassblower Laura Smith draws on her childhood home in Bermuda as the inspiration for her exquisite glass creations, blended with precious metals
What's your background?
I'm based in London, but grew up in Bermuda, which is where I saw glassblowing for the first time – I found it mesmerising. I decided to study art and design, so I came to the UK in 2003 to do my foundation year at Chelsea College of Arts and then studied glassblowing at Edinburgh College of Art.
Can you tell us about your early designs?
At college, my first attempts at glass were tiny pieces that involved lots of different processes, from layering colour in the hot shop to cutting and fusing. Art school glass was more about concepts and exploring ideas and having the freedom to develop them.
Why did you choose to blend glass with precious metals?
Initially, it was for a college project inspired by the Lascaux cave paintings of ancient animals. I was captivated by the way copper reacted to the hot glass, turning black on the surface and orange and red on the interior. I loved playing with different ways of working the copper into the glass. Later, I started using silver and gold.
What are you working on at the moment?
I'm currently working on orders from professional trade fair Maison et Objet, where I debuted my Cascade lighting collection (as seen on page 37). It's a grouping of pendants in a chandelier, arranged in an organic flow of water droplets.
How has your childhood in Bermuda influenced your glass work?
The light and colours are so vibrant in Bermuda and, growing up on an island, the elements are very much a part of everyday life. Hurricanes, storms and water shortages all highlight a beautiful yet fragile ecosystem, which inspires my work.
Talk us through your process
To make a Cascade pendant, I gather molten glass from the furnace on a blowing iron – it's like honey at this point. I blow through the iron and, once a bubble appears and the glass is the right temperature, I apply the metal to the surface of the glass. Then I gather more glass over the bubble and metal leaf. The next stage is to shape it with a wooden block and wet newspaper, which allows me to get my hands close to the glass and mould it. I use my tools to create a weakness in the neck of the glass, where, with a tap against it, the piece is transferred to the solid iron. Then it's a matter of heating the glass, shaping the neck and sizing the piece so the light fitting can be placed inside.
What are your future plans?
I'm currently developing a new lighting range using hot cast glass and cast metal. I'd also like to establish an interactive glassblowing studio, which could include different disciplines, though it's very much at the beginning stages.
See more of Laura's glass designs at lauraelizabethglass.com. Prices start from £75.
Photographs: Jesse Wild
Interview: Sophie Hannam
- Article Categories: | Decorative |


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PC client by Ubisoft that allows the downloading and purchasing of games
Windows 8.1 / Windows 8 / Windows 7 / Windows Vista / Windows XP
UPlay is Ubisoft's client to download all of your favorite games right to your PC computer.
If you are looking for a wonderful software program where you can download all of your favorite games, you are going to want to utilize a program known as UPlay. This particular program is Ubisoft's client that can be used in order to download games that are available from this manufacturer. This makes it incredibly easy for you to have all of these games right at your fingertips when using your computer at home. It saves you a ton of time and hassle because you can finally have a platform where you can keep all of your games organized.
In order for you to begin using this particular program, you are going to want to download it to your computer right away. Once you download the software, you will be able to open it and create an account in order to have everything secured and easily accessible for yourself. Once you have created an account for yourself, you can browse the immense amount of games that you can download onto your PC computer. Some of these games are going to be available for free and others may cost you some money in order to download.
Like other clients out there, UPlay enables you to browse a wide selection of different games that you might be interested in trying for yourself. You are also going to be able to read reviews from other players who have played the same game you are interested in. This will help you to determine if a game is worth downloading or if you should continue looking for something else. UPlay is one of the best PC clients out there because it finally allows you to locate a wide range of different options available on the internet. All you need is an internet connection, and you will be able to quickly and effortlessly get the games that you have always wanted to download.
You will need a certain amount of space on your system in order to download UPlay. This ensures that the entire system is going to run to the best of its ability so that you can have smooth gameplay at all times. Once you have downloaded this particular program, you are going to need to make an account in order to log in and out as you see fit. This will also keep all of your information as secure as possible when downloading your favorite games. It is a wonderful program to utilize when you would like to download a wide range of different games directly to your PC computer without having to purchase hard copies of the same games from your local game store.
Most popular 'human vs zombies' mod for Counter Strike 1.6
Patch for parents and guardians who want to disable the game's "Hot Coffee" mode
UFO is a set of tools for Skyrim, this mod allows users to to have a better control on their followers.
The fourth installment in the beloved video game series
Counter Strike 1.6 Zombie Plague
Most popular 'human vs zombies' mod for Counter Strike 1.6
Grand Theft Auto: San Andreas
Patch for parents and guardians who want to disable the game's "Hot Coffee" mode
Skyrim UFO Ultimate Follower Overhual
UFO is a set of tools for Skyrim, this mod allows users to to have a better control on their followers.
Far Cry 4
The fourth installment in the beloved video game series


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Super 8 Cowan hotels are listed below. Search for cheap and discount Super 8 hotel rates in Cowan, TN for your upcoming individual or group travel. We list the best Super 8 Cowan hotels so you can review the Cowan Super 8 hotel list below to find the perfect place.
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How should we direct your call?
Located in Monteagle, Super 8 Monteagle TN is within the vicinity of Sewanee Golf and Tennis Club and University of the South.


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FAIRFIELD COUNTY, Conn. — Looking for work in Bridgeport, Fairfield, Westport, Weston, Shelton, Stratford, Monroe, Trumbull, Redding or Easton? Here are some recent openings:
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Family Practice in Trumbull is looking for a front desk/financial coordinator with treatment planning/financial presentation skills.
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text:
William, an ambitious Realtor in his early thirties wanted more listings. He was moderately successful in the San Fernando Valley, but after moving to Orange County he found the competition between Realtors for new listings to be almost overwhelming. After months of working very hard and not seeing much fruits for his efforts he finally asked a very successful Realtor in his office to help mentor him.
"Image is key one to getting new listings", his mentor told William. "You've got to promote yourself heavily here in Laguna Niguel so that everyone knows your name and hopefully, your face." Then he told William something about his personal appearance that shocked him! "William, your teeth and smile don't look their best. How can you expect people to have confidence that you're sharp and professional when your teeth are crooked, broken and yellow? Your business card needs to have a great photo of you smiling, and when prospective clients meet you for the first time they need to know that you care a lot about yourself. Your appearance says a lot about that. They need to know that you are going to take great care of them and you are the best professional that you can be."
When William looked at his teeth in the mirror and at some of his closeup photos, he knew his mentor was right. It was time to see a cosmetic dentist.
When William came to us he told us the story. He followed it up telling us that his short term goal was to get more listings in Laguna Niguel, but his long term goal was to be one of the most successful Realtors in Orange County. He was committed to doing the hard work, but wanted us to help give him a friendly, professional, great looking smile with cosmetic dentistry.
William had done his homework before coming in to see us. He had studied his teeth carefully and knew all his "smile flaws":
- He wanted whiter teeth. His were yellow and his front two teeth didn't match.
- He wanted all his teeth to be the same color. His right front tooth had a discolored bonding which was chipped.
- His teeth were all slightly crooked and he wanted them straight.
- Four of his left side and front teeth leaned inwards (called cross bite).
We looked closely at William's teeth and he showed ten of his upper teeth when he smiled. Based on his goals Dr. Huefner recommended that he make ten porcelain veneers for William. When William looked at his teeth he felt that he only really showed eight teeth when he smiled. He asked if he could just do the eight teeth, and if later on he felt he should do two more he would. Dr. Huefner agreed he could do it that way if that was what he really wanted.
When Dr. Huefner designed William's smile he chose a "masculine" smile design from the tooth shape library. Cosmetic dentists often impart gender in the size, shape and length of the teeth. For someone like William, a big masculine guy, Dr. Huefner recommended front teeth that were a little more square on the corners. For women, especially those who want to look younger or more feminine, Dr. Huefner often will recommend the design for the front teeth to be more rounded. The "enhanced" smile design is one of the most popular design utilized for women, which is a more feminine smile design, not something well suited for him. William also chose a BL2 shade from the tooth shade catalog.
After making William the eight porcelain veneers he had a much improved smile. His teeth were whiter and all uniform in color. They were straight and the cross bite on the left side corrected by making the veneers lean out instead of leaning inwards. He got a mature, very appropriate smile design that really enhanced his professional image.
Very pleased with the end result, William couldn't wait to show off his new teeth with his mentor. He also had an appointment with a professional photographer later that week and he couldn't wait to have a portrait of the new, improved William on his business card and professional advertising.
We couldn't guarantee that William will get more listings now that he has eight porcelain veneers. But we are absolutely convinced that his improved image is going to help his career and greatly improve his chances for success in a very competitive career over his professional lifetime!


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Go back in time
Weddings have been performed for thousands of years and the style has no doubt changed with the tradition. One thing that remains to be a must is having perfect hair . In March of 2013, I had my wedding in Key West in a beautiful historic garden. Being a stylist, I immediately knew how I …View


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Angel investors are unphased by bubble hype as 2012 valuations remain unchanged versus 2011. Median deal size down slightly from 2011, but trending up in Q4. Mobile doubles its share of investment dollars, while Healthcare slips to #2 behind Internet. California loses share.
We just released our year-end 2012 Halo Report in conjunction with Silicon Valley Bank and the Angel Resource Institute. The full 33-page report recaps the entire year of 2012, including quarterly trends as well as annual comparisons versus years prior.
Highlights of the 2012 angel investing report include:
- Median Deal Size Shrinks in 2012: medial deal size among angel groups and their syndicates falls to $600k in 2012, down from $625k in 2011. In good news, however, median deal size reaches a five-quarter high in Q4 at $690k.
- Early Stage Valuations Hold Their Ground: amidst all the recent talk of an early stage bubble, angel investors remain unphased as pre-money valuations hold steady with those of 2011 at $2.5M.
- California Loses Investment Share in 2012: while California still remains the top destination for angel group investment in 2012, it loses significant share to various regions including New York, New England, the Mid-Atlantic, and the Northwest.
- Mobile Dials Up, Healthcare Slows Pulse: Mobile more than doubles its share of investment dollars in 2012. Healthcare loses significant share in terms of deals and dollars slipping to the #2 spot behind Internet as a destination for angel investment.
- A New Face Atop the Leaderboard: New York Angels skyrocket up the charts to become the most active angel group in 2012. Tech Coast Angels slips to the two-spot.