text:
In California, as in other states, the legal concept of premises liability imposes a duty to maintain the premises in such a way as to minimize the risk of injury to anyone legally on the property. This requirement has broad scope, covering all aspects of real property, from steps, stairs, ramps and decks to hallways, floors and elevators. The duty also extends to sidewalks, driveways, parking ramps and lots. The duty does not extend to trespassers, and anyone legally on the property must use the property for normal purposes or for a purpose reasonably foreseeable by the owner or occupier of the property.
But a key question can focus on just who has the duty, particularly if the property is owned by one party and occupied by another. When there's a commercial or residential lease, who has the duty to keep the property maintained and safe for visitors? As with most situations, the answer is "it depends." It's good practice, though, to notify both the owner and the tenant of any injuries you have suffered on residential or commercial property.
Injuries on Commercial Property
Most commercial leases address the issue of liability for injury on the premises. It's not your responsibility to determine, however, who has responsibility. If you notify the tenant (business owner), they'll likely pass the matter on to the building owner if their agreement imposes liability on the owner.
Injuries on Residential Property
One of the key considerations with injuries on residential property is where the accident occurred. As a general rule, the tenant has responsibility for anything moveable inside the apartment and the landlord has responsibility for everything outside the apartment, in common areas and everything immovable inside the apartment. There may be exceptions, though. If the tenant knows of a dangerous condition involving something immovable inside the apartment or something outside the apartment, if the condition is known and the tenant has not notified the landlord.
Contact the Law Offices of J. Lewis & Associates
To discuss your legal needs with an experienced Riverside personal injury lawyer, contact our office online or call us toll-free at 1-800-228-0507. There is no charge for your initial consultation. Se Habla Espanol.


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SOURCE: DryShips Inc.
November 19, 2009 20:43 ET
ATHENS, GREECE--(Marketwire - November 19, 2009) - DryShips Inc. (NASDAQ: DRYS) (the "Company"
or "Dryships"), a global provider of marine transportation services for
drybulk cargoes and off-shore contract drilling oil services, today
announced the pricing of its previously announced public offering of
convertible senior notes. The offering size was increased from $300 million
to $400 million. The sale of the convertible notes is expected to close on
November 25, 2009, subject to customary closing conditions.
The convertible notes, which are being issued at a price equal to 100% of
their face value, will have an interest rate of 5%. The convertible notes
will be senior unsecured obligations of the Company. The initial
conversion price for the convertible notes will be $7.19 per share.
The underwriter for the offering will also have the option to purchase up
to $60 million principal amount of additional convertible notes solely to
cover any over-allotments. The Company estimates that the net proceeds
from the offering will be approximately $387 million after deducting
underwriter discounts and commissions and estimated offering expenses
payable by the Company assuming the over-allotment option is not exercised.
The Company intends to use the proceeds from the offering for vessel
acquisitions and other general corporate purposes.
Concurrently with the offering of the convertible notes, the Company has
entered into a share lending agreement with Deutsche Bank AG, London Branch
("Deutsche Bank AG"), under which it will loan to Deutsche Bank AG 26.1
million shares of its common stock. The Company has also entered into an
equity underwriting agreement with Deutsche Bank Securities Inc. pursuant
to which Deutsche Bank AG or its affiliates intend to sell shares of the
Company's common stock that they will be entitled to borrow from the
Company under the share lending agreement.
These shares will be offered in an underwritten offering registered under
the Securities Act of 1933, as amended, pursuant to the Company's existing
shelf registration statement in order to facilitate hedging transactions
undertaken by the purchasers of the convertible notes. The Company will
not receive any of the proceeds from this sale of common stock but will
receive a nominal lending fee from Deutsche Bank AG under the share lending
agreement. Deutsche Bank AG will be required to return the borrowed shares
on or about the maturity of the convertible notes or, if earlier, upon the
conversion, repurchase, cancellation or redemption of all of the
convertible notes and upon the occurrence of certain other events. The
delivery of common stock pursuant to the share lending agreement will be
contingent upon the closing of the convertible notes offering, and the
closing of the convertible notes offering will be contingent upon the
delivery of common stock pursuant to the share lending agreement.
Deutsche Bank Securities Inc. is acting as Sole Book-running Manager for
the offerings.
This announcement does not constitute an offer to sell or the solicitation
of an offer to buy the convertible notes, common stock or any other
securities, nor will there be any sale of convertible notes, common stock
or any other securities in any state or jurisdiction in which such offer,
solicitation or sale would be unlawful prior to registration or
qualification under the securities laws of any such state or jurisdiction.
The convertible notes and the common stock will be offered only by means of
a prospectus, forming a part of the Company's shelf registration statement,
related prospectus supplements and other related documents. You may obtain
these documents for free by visiting EDGAR on the Securities and Exchange
Commission website at www.sec.gov. Alternatively, copies may be obtained
from Deutsche Bank Securities Inc., Attention: Prospectus Department, 100
Plaza One, Jersey City, NJ 07311 or at 800-503-4611. Before you invest,
you should read the prospectus supplements and accompanying base prospectus
along with other documents that the Company has filed with the Securities
and Exchange Commission for more complete information about the Company and
these offerings.
About DryShips Inc.
DryShips Inc., based in Greece, is an owner and operator of drybulk
carriers and offshore oil deep water drilling that operate worldwide. As of
the day of this release, DryShips owns a fleet of 39 drybulk carriers
comprising 7 Capesize, 30 Panamax and 2 Supramax, with a combined
deadweight tonnage of over 3.4 million tons, 2 ultra deep water
semisubmersible drilling rigs and 4 ultra deep water newbuilding
DryShips Inc.'s common stock is listed on the NASDAQ Global Market where
trades under the symbol "DRYS".
Visit our website at www.dryships.com.
Forward-Looking Statements
Matters discussed in this release may constitute forward-looking
statements. Forward-looking statements reflect our current views with
respect to future events and financial performance and may include
statements concerning plans, objectives, goals, strategies, future events
or performance, and underlying assumptions and other statements, which are
other than statements of historical facts. The forward-looking statements
in this release are based upon various assumptions, many of which are
based, in turn, upon further assumptions, including without limitation,
management's examination of historical operating trends, data contained in
our records and other data available from third parties. Although DryShips
Inc. believes that these assumptions were reasonable when made, because
these assumptions are inherently subject to significant uncertainties and
contingencies which are difficult or impossible to predict and are beyond
our control, DryShips Inc. cannot assure you that it will achieve or
accomplish these expectations, beliefs or projections. Important factors
that, in our view, could cause actual results to differ materially from
those discussed in the forward-looking statements include the strength of
world economies and currencies, general market conditions, including
changes in charterhire rates and vessel values, changes in demand that may
affect attitudes of time charterers to scheduled and unscheduled
drydocking, changes in DryShips Inc.'s operating expenses, including bunker
prices, drydocking and insurance costs, or actions taken by regulatory
authorities, potential liability from pending or future litigation,
domestic and international political conditions, potential disruption of
shipping routes due to accidents and political events or acts by
terrorists. Risks and uncertainties are further described in reports filed
by DryShips Inc. with the US Securities and Exchange Commission.
Investor Relations / Media:Nicolas BornozisCapital Link, Inc. (New York)Tel. 212-661-7566E-mail: email@example.com
See all RSS Newsfeeds

subset: commoncrawl


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Spot-on Guide for New Players in Bitcoin Casinos
Bitcoin gambling debuts in the online gaming scene with little fanfare, but it has escalated to a continually expanding industry as more people become acquainted and enter the world of bitcoin and digital currency.
The beauty of it lies on the simple fact that it is not too distant from how one plays online casino games using real money. However, it boasts its own unique characteristics that require even the seasoned players in fiat-operated casinos to take time and learn the basic rules before gambling in a Bitcoin casino.
Rule#1: Understand Bitcoin and Gambling
Bitcoin and gambling are two separate entities that are already interesting on their own; that is why combining them creates a rather new dimension that may seem alienating to some, but revolutionary to many. It is for this very reason that a solid grasp of the fundamentals of bitcoin is necessary as lack of understanding is the main cause of resistance against it.
Moreover, gambling should be perceived as a form of entertainment, not as a profit-making activity. Therefore, it becomes the players' sole responsibility to control their gambling habits, which can be done by following a strict schedule for playing Bitcoin games, limiting the bankroll, and simply knowing when to stop.
Rule#2: Check Reputation of Bitcoin Casinos
Scams and threats have become prevalent in the online gaming sector, so it is only logical to guarantee the reputation of the bitcoin casinos before playing. However, sometimes, online reviews can only go so far; thus, it is also advisable to check the interface and have a tour around the platform to help assess the website's reliability.
Rule#3: Ready Bitcoins and Wagers
New players must never deposit and wager large amounts of bitcoin right away. Instead, allotting a small portion of the bankroll is advised. This is a great way to test the platform, especially the payment system. When it comes to the payment processes, taking note of the number of confirmations required, the deposit and withdrawal limits, and the transaction fees involved.
Rule#4: Ensure Security of Account and Wallet
Keeping the funds in the wallet instead of storing them in the accounts in casinos is the smartest thing to do in order to safeguard funds from possible threats and losses. This is but one way to guarantee security while playing in a Bitcoin casino online. Another is to choose a wallet that offers more features catered to protect bitcoins. A multi-sig wallet is a good option or keeping the bulk of bitcoins in a cold storage and having another wallet with bitcoins specifically for gambling is a good practice.
Rule#5: Be Open to New Bitcoin Casino Games
One of the charms of Bitcoin gambling is it is flexible. It manages to introduce games that present innovations and still offer high levels of entertainment. Thus, adapting to the different games, be they Bitcoin slots, roulette, dice, and many other card and table games, will be the key to fully enjoy the experience in gambling in a Bitcoin casino.


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Description: This is my new energetic corporate soft modern rock loop track with positive bright mood, which contain bright electric guitars, live rock drums, bass…This driving track can be used anywhere – as a motivational musical background for websites, in computer arcade games, tv or radio jingle, advertisement and commercial video etc…Enjoy and thanks for buying!:)
Genres: Royalty Free Music , Variety
Description: Summer Adventure is a feel-good song inspired by the arrival of the summer sun. The fun melodies and happy vocals give a feeling of a fresh start with the sun shining on a hot summer's day. Ideal for adverts or a short video montage, Summer Adventure makes the perfect accompaniment to scenes with joyous content, such as active children playing/exploring, a couple in love smiling and having fun, or a group of happy friends travelling to a music festival.
Description: beautiful pop instrumental rich in piano & strings.
Description: This is my new inspiring motivational, positive soft pop rock track with corporate mood, which can be used in business commercial promo slideshows, happy joyful video, holiday and celebration events. Track included soft rock drums, electric guitars solo and bright bass…These track can be also used in wedding photo and video, arcade computer games and emotional movies, nice events – birthday, christmas, valentine cards, as a musical background for advertisement, websites etc…Enjoy! and thanks for buying!:)
Description: energetic, walking melodic bass line, congas.
Description: beautiful instrumental with piano & strings ideal for a wedding as the bride & groom walk down the aisle.
Description: This is a short version of a well known traditional Scottish song.Ideal for Scottish setting or having a jig.
Description: great electronic track, dramatic synth, guitar, heavy beat.
Description: french song pop.
Description: instrumental featuring piano, drums & orchestration.


text:
It's easy to fall in love, what's difficult is to stay in it. One must be aware of all the ups and downs a relationship will face being together. Two individuals when fall in love, mostly unaware of this fact forgets about the basic necessity of it which is-Expressing Love For Each Other. Compliment each other, devote some quality time together and trust us you'll get the true essence of love in your life. Couple Goals –
1. Wearing Same Tees Together
Source: Pinterest
That will surely melt your heart as the world will know you're together and indulged into each other.
2. Gym Is A Happy Place When You Both Are Together
Source: livestrong
Who wouldn't mind working out with "bae" and getting his utmost attention.
3. Hugging And Cuddling As If Nothing Going To Separate You Both
Source: Instagram
Hug each other like no one cares!!
4. Surprising Each Other – Couple Goals
Source: Pinterest
Ain't we all love surprises?
5. Not Caring About How We Look – Couple Goals
Source: creativefan
Silly faces, with or without makeup. Who cares? Look doesn't matter anymore when you know you both are made for each other.
6. Kissing Is Your Favorite Task Together – Couple Goals
Source: flickr
And that's my favorite too.
7. Travelling Together – Couple Goals
Source: myfatpocket
That makes your bond stronger than ever before. #CoupleGoals
8. Getting Inked Together
Source: tattooblend
Isn't this is the best feeling of getting each other's name written on each other.
9. Cooking Together
Source: Pinterest
Meals made from love. *Point Justified*
10. Raising A Pet Together
Source: lonacardaro
Your love will grow along with your pet.
11. Reminding Each Other How Much You Love
Source: Pinterest
Through shallow path to deep dives, you're truly into each other. Tell what you feel or how you feel about him/her.
12. Couple Goals Are Incomplete Without Some Memories Captured At The Right Time
Source: tumblr
Adorable Pictures will revive those memories.
13. Sleep Together – Couple Goals
Source: Pinterest
As a person who can love your morning face is definitely a "keeper".
14. A Romantic Dance On "Thinking Out Loud" By Ed Sheeran
Source: Pinterest
That's truly the most romantic song ever made.
15. And Last But Not The Least- Grow Older Together
Source: Pinterest
I will love you till my last breath.
These couple goals are something that you must fulfill if you're in love. Truly, Madly, Deeply!!


text:
Benefit from varicose veins treatment before the holiday!
Benefit from the excellent method for varicose veins removal, a perfect solution for the summer – endovascular adhesive varicose vein procedure. Varicose veins are much more than just a cosmetic problem. This is also a serious and health problem, its severity increases over time. A feeling heaviness, leg pain and swelling after all dayRead more →


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Les Hamilton joins Hyland's
LOS ANGELES — Hyland's on Monday named Les Hamilton as its VP sales. In his new role, Hamilton will be responsible for guiding the company's sales organization and developing and implementing sales strategy.
"I have known Les for many years and I am confident that he brings to Hyland's the right mix of experience, accomplishment and culture that aligns perfectly with our core values," Hyland's president Dale Nepsa said. "Les will be working closely with our outstanding sales teams in both natural foods and food, drug and mass merchandisers. He will be a valued member of our senior management team, providing a comprehensive sales perspective to the operations of our company."
Hamilton joins Hyland's from The Emerson Group, where he served as field sales manager. While with The Emerson Group, Hamilton managed accounts of all sizes, most recently managing the Target business for all of Emerson's over-the-counter products. Hamilton's prior experience includes almost 10 years at Target, where he held different positions, including category manager for numerous pharmacy categories and all OTC private-label items.
Hamilton graduated from Indiana University with a Bachelor of Science degree in both marketing and management.
Bristol-Myers Squibb to present at The Liver Meeting
PRINCETON, N.J. — Bristol-Myers Squibb will present 22 study abstracts next month at the 62nd annual meeting of the American Association for the Study of Liver Diseases in San Francisco, the company said.
Key presentations set to take place at the meeting, called The Liver Meeting, include studies on the hepatitis B drug Baraclude (entecavir) and drugs under development for hepatitis C and liver cancer.
"Bristol-Myers Squibb is at the forefront of innovation in researching the treatment of liver diseases," Bristol-Myers Squibb SVP global development and medical affairs for research and development Brian Daniels said. "In hepatitis C, where there remains considerable unmet medical needs, our goal is to increase treatment options for patients by developing a portfolio of compounds with different mechanisms of action."
Interested in this topic? Sign up for our weekly Retail Health Provider e-newsletter.
Overseer of Target's Canadian expansion quits
MINNEAPOLIS — Michael Francis, Target's EVP and chief marketing officer, and the person charged with leading the retailer's expansion into Canada, has left the company, Target announced Monday.
"We would like to thank Michael for his many contributions and wish him the best in his future endeavors" said Target chairman, president and CEO Gregg Steinhafel said.
Francis will continue his career as president of JCPenney, effective Oct. 4, where will be responsible for all merchandising, marketing, planning and allocation, and product development and sourcing functions for the retailer. He will report to incoming JCPenney CEO Ron Johnson.
Regarding his new position, Francis said, "This is a tremendous opportunity for me to get back to department store retail. I began my career working on the sales floor of the State Street Marshall Field's in Chicago. It was there where my passion for retail began and my understanding of the power and potential of the department store was formed. I am delighted to join JCPenney and work with Ron and the talented JCPenney team to help accelerate the momentum already taking place."
Back in January, Francis was named the executive committee sponsor of Target's entrance into the Canadian market. In this role, Francis was to oversee the extension of Target's brand as part of the corporation's first-ever expansion of its stores beyond the United States.
At the time of the announcement, Steinhafel said, "With more than 25 years of experience with this corporation, Michael has a deep understanding of Target and the retail industry. His responsibility for corporate brand and reputation including our community relations efforts uniquely position him to lead this effort."
Target intends to open its first Canadian stores in 2013 and has yet to provide details on who will continue Francis' efforts after his departure.


text:
Armed man forces woman to hand over car in Gentilly, police say
Armed man forces woman to hand over car in Gentilly, police say
A woman was carjacked by a gun-wielding man Tuesday evening in Gentilly, police said.
According to the New Orleans Police Department, the incident was reported around 11 p.m. in the 2500 block of Lavender Street.
The initial NOPD report says that a 38-year-old woman was in her car when an unknown man armed with a gun got inside through the passenger side door.
Police said the perpetrator pointed the gun at the woman's face and told her to get out of the vehicle. She complied, and the man left with her car.
No description of the suspect or the stolen vehicle was provided.
Anyone with information is asked to call Crimestoppers at 504-822-1111.


text:
Did you know that Natural Nail Polish Colours is most likely the most popular topics on this category? This is exactly why we're showing this topic at this moment. We took this picture from the net that we consider would be one of the most representative pictures for Natural Nail Polish Colours.
We know everyone's opinion will be different from each other. Similarly to this graphic, within our viewpoint, this is one of the greatest picture, now what is your opinion?
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Any content, trademark/s, or other material that might be found on the Jcpronet.com website that is not Jcpronet.com's property remains the copyright of its respective owner/s.
In no way does Jcpronet.com claim ownership or responsibility for such items, and you should seek legal consent for any use of such materials from its owner.


text:
Viewer Tips Help Catch Fugitive
Viewer Tips Help Catch Fugitive
A fugitive was arrested thanks to local tips, including those from WMUR viewers.
The U.S. Marshals Service said Michell Durgin was arrested Wednesday afternoon.
Click Like For NH News Updates:
He was wanted for probation violation stemming from a sexual assault conviction.
Authorities said he also failed to register as a sex offender.
Durgin was featured as a fugitive on Most Wanted Wednesdays on WMUR.com.
"The public continues to be the eyes and ears of law enforcement. We are very fortunate to have so many people on the lookout for these dangerous people in our communities," said U.S. Marshal David Cargill, Jr.


text:
The Unpracticality of Beauty is one of two duets, made as reflections on a man-hood and women-hood with their different aspects in the Middle-Eastern and Western culture.
In the frame of Cairo Downtown International Arts Festival (D-CAF) The100Hands have created for two subsequent years performances for downtown public space. The Unpracticality of Beauty is one of the two duets Jasper and Mojra made after their working experience in Egypt. It reflects on the image of a woman's body in our different societies, the covered and the exposed, the hidden and showed-off. It is looking at the universality of being a woman, exposing her strength, her fragility, her hips, her hair and their expression – it all seems to be complex and often rather unpractical.
Tender Violence is danced by two man: a Dutch and an Egyptian dancer, while The Unpracticality of Beauty is danced by two women: a Slovene and an Egyptian. Both duets invite men and women alike to watch, experience and share opinions.
Premiere: 20 Mar 2015 in D-CAF Cairo, Egypt
Concept: Jasper Džuki Jelen and Mojra Vogelnik-Škerlj
Choreography: Jasper Džuki Jelen, Mojra Vogelnik-Škerlj
Performed by: Jasper Džuki Jelen, Khadija Usef, Mohamed El Deep and Mojra Vogelnik-Škerlj
Music: Mohamed Shafik
Costumes: Jasper Džuki Jelen and Mojra Vogelnik-Škerlj with the cast
Production: Orientproductions / D-CAF International Contemporary Arts Festival Cairo, Egypt. 2015
Support: The Dutch Embassy in Egypt, Studios Emat Eddin


text:
Ivory and Co Clementine Tiara
£135.00Code: THR080
Clementine tiara by Ivory and Co using swarovski crystal and cubic zirconia. A stunning low height tiara influence by Victorian design incorporating curls offset with solitaire stones.
- Centre height: 2.8cm approx.
- Silver Plated
- Also available to order in 14ct Gold Plating
- Presented in a luxury, Ivory and Co tiara box
A beautiful, vintage style tiara in a classic design - ideal if you want to create subtly elegant bridal look!
Other similar products in this category...


text:
Jack Chambers (Success, Elite) was scouted in late 2012, while shopping with his dad in his hometown of Oxford, and has since made quite an impact. He made his runway debut in January 2013 opening Topman's Fall/Winter 2013 show, and went on to walk for J.W. Anderson, Burberry, Jil Sander, Dior Homme, Raf Simons, Kris Van Assche, Dries Van Noten, and Louis Vuitton, among others. He has appeared in the Topman Lux Spring/Summer 2013 ad campaign and Christopher Kane's Spring/Summer 2014 lookbook, and has graced the pages of Grit magazine, AnOther Man, Fucking Young!, and Harper's Bazaar China - just to name a few. And in case that's not enough, Models.com named him one of the Top Men's Newcomers for the F/W 14 season. We caught up with Jack, who spoke us about music, why he didn't think he was model material, models.com and more ...
The Fashion Law - How old are you now?
Jack Chambers - I'm 20. Turning 21 in July.
The Fashion Law - And you are originally from Oxford, right?
Jack Chambers - Yeah. I'm from a large village just north of Oxford. It's all picturesque colleges and discount-hunting tourists.
The Fashion Law - Are you still currently in university?
Jack Chambers - I'm actually taking some time out of Uni to focus on modelling and just living! I was studying English and Media at Southampton Solent.
The Fashion Law - Prior to being discovered did you think you were "model material"?
Jack Chambers - I can't say I really thought about it at all before I was scouted. I got the standard comments from my parents about my appearance but, as lovely as they were, they sort of went straight over my head. Every parent says their kids are beautiful! I've never been overly confident with my looks, particularly my skinny frame, so that was another reason I never thought about my look being something people would be interested in. I guess no would be the short answer to that question!
The Fashion Law - What is the best part, in your opinion, about being a model? (Other than travelling - which is usually everyone's first answer)
Jack Chambers - I guess it'd be the lessons you learn along the way. I've been modelling for over a year now and I've already grown up and learnt a lot through it. Learning to manage your time efficiently, dealing with rejection, making new friends, coping in foreign surroundings. Everything you go through, especially for someone around my age, is another lesson to take with you forever.
The Fashion Law - What has surprised you the most about the fashion/modelling industries?
Jack Chambers - Just how much work goes into it! So many people say to me "Oh it's not a real job, you just get paid ridiculous money to walk up and down in a straight line or pull a few poses then go home" and, although I was never quite that ignorant, I never would've expected just how many hours go into a single fashion show, for everyone involved.
The Fashion Law - How do you think you are different from other models?
Jack Chambers - I'm struggling to answer this question without coming across sounding arrogant but I guess I'm a bit more humble than some other models. I've met so many great guys in this job but when I see some models having a bit of a moan or a 'diva moment' over certain things I realise that I'm very happy to sit back, be nice and friendly and never adorn the sense of entitlement that some guys seem to have. Even then, I'm referring to 1% of models I've come across, the majority have been amazing people. I'm not that fashionable unlike a lot of models. I love the high end labels I get to wear but if you see me walking around Southampton on a Thursday afternoon then I'll be head to toe in street wear brands.
My music taste is pretty different too! I'd much rather go to an intimate hardcore show at the Underworld than a warehouse rave.
The Fashion Law - Do you feel like modeling is something you just kind of fell into or is it something you are passionate about?
Jack Chambers - I'd definitely say I just fell into it to begin with but it seems like the more I immerse myself into the fashion world, the more passionate I become about it. I'm more intrigued by the work I'm doing and the work going on around me and I'm definitely appreciating the whole industry a lot more than I ever would've done if I hadn't had this opportunity.
The Fashion Law - You had a really great season. In fact, Models.com named you one of itsTop Men's Newcomers for the F/W 14 season. Any thoughts on this?
Jack Chambers - I was over the moon when I saw that I was on the list of top newcomers. I think it's kind of hard to gauge just how well you're doing as a model. So, to be recognised by Models.com was really great. A nice bit of recognition after all the early starts and late nights spent casting!
The Fashion Law - You said that you've never really been super confident with your looks. Have you changed your mind since you started modeling?
Jack Chambers - That's a hard one to answer. I think I'll always be conscious of my size. After years of being picked on and labelled as "the stick insect" at school, I think I'll always have a niggling issue with my skinny frame. The job has given me a bit more confidence, not necessarily about my looks but just in general. It's definitely nice knowing that no matter how you feel about yourself, someone out there clearly likes you if you're still managing to get work!
The Fashion Law - Last one ... what are you obsessed with right now?
Jack Chambers - Re-learning to skateboard, Schoolboy Q and, as always, hardcore and street wear!


text: I'm sure this has been answered before, and I've already read the guides to soft-modding a Wii. I just wanted to know the difference between what a hard modded Wii can do versus a soft modded Wii. I think I will attempt to soft mod my Wii later just because it seems pretty simple and harmless, but what can a soft modded Wii actually do? Is it a huge pain in the ass to get pirated games to work? Are there risks for bricking?


text:
Japan 2X Moisturizing Facial Tissue
After two years of research and developments, the world's first moisturizing tissues are extremely soft and smooth to the skin. The patented tissues contain moisturizing ingredients often found in cosmetics such as glycerin and sorbitol that absorb moisture from the air. As a result, each tissue contains about twice the amounts of moisture as regular tissues. With small amounts of oil and emulsifier added to every single piece of Kawano's best-selling tissue, it soothes the skin with every touch. Those with sensitive skin and who **** their noses often can use this product with full confidence. A good replacing/alternative product for your Kleenex or Puffs.
1. Moisturizing ingredients and emulsifier are perfect for those suffering from nasal inflammation, hay fever, and seasonal allergies
2. Contains twice as much moisture as regular tissues (weight per pack will change due to varying amount of moisture in the air)
3. Less lint to prevent sneezing; 100% virgin pulp guaranteed
ten tissues per pack, 16 packs per order; compact-size, perfect for traveling
4. Patented formulas from Japan; world's first moisturizing tissues
I received complimentary product.


text:
Customer Relationship (Kuala Lumpur)
Hi I'm looking for a motivated CRM person, you have to be driven, have a good appointment generation history and good contacts within Malaysia. You maybe a Wife with a background in sales who would like to get back to work!
If this sounds like you call me now on Protected content let's have n informal chat.


text:
I have came to the conclusion I suck at keeping a blog. To make this worse, I read hundreds of the damn things, I just really struggle to sit down and go, yup, thats worth putting down.
Anyways, exhibition is now up in Clon and a great opening night was had by all (It did take the few days to recover from that one)
I have also updated a few of the galleries, just a few new bits and pieces here and there. Again, I sat down and looked at the back log of work that had never made it onto the site and wanted to kick myself.
Things like this, from a amazing weekend I had in Clare a few months back
And this
Twas a lovely Sunday afternoon for a walk on the beach, it was not a lovely afternoon for swimming about the place.
Or EVEN this one, Lunch at the bar. It hurt to be working that day I can tell you...
I do have quite a bit coing up in the next couple of months but as always, Im terrified to announce anything until I know its going to happen, but once I do, I will put it up here. Soon, I swear.
On a unrelated note, I want to try organise a bit of a different photo shoot, soooo, does anyone out there in the www wide world, know where I could get my hands on a mermaid tail? If you know someone willing to wear it, even better, but at the moment, Im just going to start with the tail.
And just cos there's reems of these gone into the galleries lately, here's a wave, froze in time.
And just in case anyone really likes what they see, the shop is now back open on the gallery pages, I try to print everything on hahnemuhle bamboo archival grade paper (the bamboo just gives these amazing creamy warm tones), so you are getting absolutely amazing value for amazing pieces of art!
January February March April May (2) June (2) (1) July (1) (2) August (2) (2) September (2) (2) October (2) (3) November (3) December
(1) January (1) (2) February (2) March (2) April (2) (4) May (4) June July August September (1) October (1) November December
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Traffic Does Not Equal Audience
Making coffee this morning with one of the network news shows on in the background, I caught the tail end of an interview with Michael Wolff. Wolff, the provocative essayist, author, and columnist, was promoting his latest book, "Television Is the New Television". Something he said reminded me of Pamela Anderson.
Ok. I'm hooked… let me read the full article →


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EUDRAC is a European specialised regulatory affairs and pharmacovigilance consultancy company providing support to our clients to drive products through development, registration, market launch and post-approval activities across all EU countries.
EUDRAC is based in Germany, France and the UK, since 2002.About us
Taking several years of hard work and effort to get to a point where a product can enter the market, it is crucial to...Learn more
EUDRAC manages our clients' Marketing Authorisation Applications submitted via both the Centralised and Decentralised/...Learn more
During the lifecycle of a medicinal product, the Marketing Authorisation has to be maintained according to up-to-date...Learn more
Being aware of regulatory requirements that are being developed, or discussed, by Regulators provides insight into the...Learn more
Pharmacovigilance (PV or PhV), also known as drug safety, is the science and activities relating to the detection,...Learn more
New regulations for medical devices entered into force on 25 May 2017. EUDRAC provide services for the development and...Learn more
The EUDRAC team have partners in all European Union countries and other regulatory regions. We undertake specialist...Learn more
EUDRAC Ltd is extremely proud to have won a 2018 Queen's Award for Enterprise in the International Trade category.
The Queen's Awards for Enterprise are the UK's most prestigious business awards, recognising and celebrating business excellence across the UK
Our customised packages aim to meet the needs requirements of both small and large healthcare companies. We have become valued and integral members of our clients' project teams.
This has lead to a high level of repeat business and ongoing long–term assignments with our clients and is proof of the excellent service EUDRAC provides.
Contact us below to help you to achieve your goals!Contact
It has been over a year since the EMA implemented Policy 0070 on the Publication of Clinical Trial Data; the EMA have published a guidance document...Read more
Carole Pugh and Karen Goode of EUDRAC attended the recent reception hosted by Prince Charles at Buckingham Palace to celebrate the winners of the...Read more
EUDRAC will be exhibiting at the annual DIA Annual Meeting in Boston, United States of America from 24th to 28th June 2018. Our team would be pleased...Read more


text: Left Out Festival LGBT Photograph: Joel Bischoff Left Out Festival: NSA (pictured, from left: Casey Burden, Afrim Gjonbalaj, Kevin Pérez) 0 Add review Time Out says Details Users say Time Out says This LGBT festival includes work by Rory Lance, Manuel Igrejas, Elise Forier Edie and others. Proceeds benefit Bailey House. Details Event website: http://stageleftstudio.net Users say LiveReviews|02 people listeningSign inWrite reviewMost helpfulMost helpfulHighest ratingLowest ratingNewestOldestLoadingundefinedNew CommentsRefreshShow More Share Tweet


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Make gifts of Stocks & Securities, transfer ownership of Life Insurance Policies or donate property.
Make an endowed gift or create a scholarship.
Many employers sponsor matching gift programs and will match any charitable contributions or volunteer hours made by their employees.
Each year, thousands of Queen's graduates return to campus to reunite and celebrate with classmates.
Find information on your class reunion and how you can get involved in Homecoming.
Learn more
Queen's is more than a collection of bright minds—it is made up of people who want to learn, discover, think and do. Learn about ways you can support Queen's.
Queen's University is situated on traditional Anishinaabe and Haudenosaunee Territory.
Queen's UniversityKingston, Ontario K7L 3N6
Phone: 613-533-2060Toll free: 1-800-267-7837Email: email@example.com
© 2018 Queen's University. All Rights Reserved.


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This wonderful photo has been all over the Internet lately. It truly captures the loving connection between twin toddlers and their beautiful new set of twin sisters.
A photographer named Juliet Cannici captured this adorable shot of her first set of twins welcoming in the second. What a beautiful moment! ❤ (Credit: Facebook/West on Jade Photography) #9Today
Posted by TODAY on Friday, February 17, 2017
Some have wondered why both pairs of twins are naked in the picture. After all, it's not unusual for newborns to appear without clothing in photos like this, but toddlers are another story.
While some have assumed this is an artistic choice, the real story behind it is far sillier.
Apparently it's time to get them a bike…
Posted by Nikki And Juliet Cannici on Tuesday, December 29, 2015
When photographer Juliet Cannici welcomed a second set of twins named Gia and Gemma into her family, she wanted to capture the moment by taking photos of them with their older siblings, Nico and Siena.
Initially, she had planned for her toddlers to wear fancy outfits rented from a local boutique, but Nico and Siena hated the clothes, which unfortunately came through clearly in the photos.
Posted by Nikki And Juliet Cannici on Monday, July 18, 2016
"I was so set on capturing Nico and Siena holding the babies in the outfits I had rented. Nico and Siena were SO bored with me, the photos looked terrible. The babies just sagged lower and lower until they were practically on the ground instead of in their arms," Cannici told PopSugar.
"You should've heard me and my bribery tactics: 'Do you want M&Ms? Jelly beans! I'll give you four jelly beans each! What do you mean you don't like jelly beans? They are your favorite!' It was not my finest parenting moment."
Disappointed, Cannici decided to give her kids a break, hoping they'd have an easier time with the shoot after a bit of playtime. She took off their clothes so they could run around happily and comfortably.
Posted by Nikki And Juliet Cannici on Thursday, March 9, 2017
When it was time to shoot again, the toddlers got into position, laying on the ground, each of them holding a baby in one hand while high-fiving with the other hand. It was the perfect shot, except they still weren't clothed!
Still, Cannici ran with it. She told her kids to "act goofy" to get the big beautiful smiles she was looking for.
Now that photo has been shared across multiple websites. The TODAY post alone has over 16,000 reactions! It just goes to show that sometimes things don't go according to plan.
In this case, it seems the Cannici family is better for it!


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The IABC Regional Leadership Institute will be held in Sydney, Australia, from 27-29 November 2015.
This is the first Leadership Institute to be held in our region since 2012, and is a great opportunity to bring together Chapter Leaders and volunteers to share ideas, develop leadership skills, strengthen connections, and build a stronger network across the Asia Pacific region.
We are very pleased that IABC Chair, Michael Ambjorn, will be attending the Leadership Institute. View the full program.
Get tickets here
Join us for the key event and meet IABC's International Chair as well as colleagues from across the region. We'll have great guest speakers, an engaging program, and the chance to network and exchange views with Chapter leadership colleagues from the Asia Pacific region.
Leadership Institute
- 9.00am to 5.00pm Saturday 28 November
- 8.30 to 12.00 midday Sunday 29th November
Social program
A social program with a Welcome Reception on Friday 27th November from 5.00pm and a Dine Around on Saturday 28th November. Registration details for these events will be sent following booking.
Delegates from Asia will be eligible to apply for a scholarship to assist with travel costs. Sponsorships are limited and to qualify members must be good standing order and be able to demonstrate merit, need, their contribution to the region. Further information is here. Please apply by Friday 30th October.
Our thanks go to volunteers from IABC NSW for assisting with local arrangements, as well as Randstad for their generous support.
Saturday, 28 November 2015 at 9:00 AM – Sunday, 29 November 2015 at 12:00 PM (AEDT)
Sydney – 123 Pitt Street Sydney, NSW 2000 AU – View Map


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- Flexibility. Choose your payment date.


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Library Depository Retrieval Facility (LDRF)
Collections @ The LDRF
How To Access Materialslocated at the Library Depository Retrieval Facility
General Library Materials
Search our catalog
(filter location: 'Library Depository Retrieval Facility')
or Call to visit
Archives & Special Collections
Search our catalog
(filter location: 'SPEC')
to view archival materials
Library Depository Retrieval Facilityoff-site storage & reading room
about "LDRF"
The Library Depository Retrieval Facility (LDRF) houses Archives & Special Collections materials and general library materials identified by "Available at Library Depository Retrieval Facility" in our catalog. Although these materials are not housed at one of our branch locations, you can still view and use these materials.
about Archives & Special Collections
For more information about scheduling an appointment to view materials, searching and browsing our collections, and any other ways we can help you access Archives & Special Collections materials, visit Using Archives & Special Collections.


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Are you ready to build your own driving school website? This is fast and easy! In fact, we believe it cannot be made any quicker, simpler or cheaper than this.
This is an opportunity to attract more learner driver students to your school of motoring (SOM). Whether you operate your business alone or you manage a team of driving instructors, this website will scale up or down to meet your requirements. What's more, the end result looks highly professional and it can be customised to suit the needs of your local business.
1) Start
So, you start here: Driving Instructor Website Templates.
2) Finish
And when you are finished, you can have your own driving instructor website: Driving School Website.
This is a website builder and we offer two main methods for you to create a website:
1) Web Design Template
This option is ideal if you are just getting started and you need a website solution with the minimum amount of fuss. Just tell us the name of your business - and using our unique web templates, you can be up and running on the internet in no time at all. To get started, you can buy this web design template and the price starts at only £7 per month (other currencies on offer: US $11; Euro €9; Canadian $14; Australian $16).
The cost is very cheap, but the end result looks slick and professional. You can actually turn off the link to QuickontheNet.com (a.k.a. 'No footer bar') and hide the fact that this is a low-cost solution.
2) Create your own Website Design
You can take it a stage further and use our site builder for building your own website from scratch. This option is perfect if you have your own business logo and branded design scheme.
Either way, it doesn't matter which option you choose, because you still get full access to our web builder toolkit, whether or not you choose to purchase one of our creative 'click and buy' templates, or build your own site from scratch.
Key Features List
The key features are listed below:


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This is the first of many! Aunt Stephanie and I are going to review my family's history on back to Europe. This will serve as a record for me to share with my family now and in the future. Please feel free to listen, you may want to do the same some day! Life goes by way to quick and the "spoken word" gets lost. So that is our plan, to save the "spoken word" and pass it down. Have a great day!
Podcast: Play in new window | Download


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Results 81 - 100 of 345rss feed
High-status project managers perform worse and fail more often than the average employee
18 Jan 2017
Doctoral research carried out by Amsterdam Business School assistant professor Balazs Szatmari (Entrepreneurship & Innovation section) concluded that projects carried out by high-status project managers were more ...Read more
New Director of ABS Research Institute
10 Jan 2017
The Amsterdam Business School (ABS) is pleased to announce that Prof. Deanne den Hartog has commenced as Director of the Amsterdam Business School Research Institute as of 1 January 2017. At this time ABS would like ...Read more
Martijn Dröes wins VOGON/PropertyNL Research Award 2016
13 Dec 2016
Martijn Dröes (Amsterdam Business School, Finance Group) has won the VOGON/PropertyNL Research Award 2016.Read more
Lack of tolerance undermines diversity-training effectiveness
12 Dec 2016
Many organisations today employ diversity training as a way to effectively manage an increasingly diverse workforce. Despite its noble objectives, however, such training is often ineffective and can even exacerbate ...Read more
New Amsterdam School of Data Science offers wide range of courses
7 Dec 2016
The Amsterdam School of Data Science is a new initiative offering a wide range of courses in data science. The school has much to offer to anyone interested in studying Data Science and it also facilitates training ...Read more
Amsterdam Business School first CFA Approved Prep Provider in the Netherlands
6 Dec 2016
The Executive Master in International Finance Programme at the University of Amsterdam's Business School (ABS) was recently chosen as the first CFA Approved Prep Provider in the Netherlands. A CFA qualification is ...Read more
Research into ethical leadership within projects
30 Nov 2016
The University of Amsterdam is conducting research on integrity and ethics within projects and project management in collaboration with IPMA-NL, the industry association for project management.Read more
EIAP recognised as a Center for Internal Audit Excellence
29 Nov 2016
The Amsterdam Business School's Executive Internal Auditing Programme (EIAP) participates in the Internal Auditing Education Partnership (IAEP) of the worldwide Institute of Internal Auditors (IIA).Read more
The Analytics Academy selected as ICT training provider of the year
2 Nov 2016
The Analytics Academy, a joint initiative of the UvA's Amsterdam Business School, Amsterdam Data Science, and Ortec has won the Computable Award in the category 'ICT-training provider of the year'.Read more
Tsvi Vinig named Kuang Yaming Professor at China's Jilin University
18 Oct 2016
Tsvi Vinig of Amsterdam Business School's Entrepreneurship and Innovation section has been appointed the Kuang Yaming Professor at Jilin University. This appointment is granted for making a distinctive contribution ...Read more
New ABS course Financial Regulation and Shadow Banking
14 Oct 2016
The ABS is offering a new two-day course on Financial Regulation and Shadow Banking, with the first edition scheduled for 30 November and 1 December at the Amsterdam Business School.Read more
Prof. Arnoud Boot presents report 'Balancing Society and the Financial Sector' to Dutch Minister of Finance
13 Oct 2016
On 12 October, Prof. Arnoud Boot of the University of Amsterdam and member of the Scientific Council for Government Policy (WRR), presented the report 'Samenleving en financiële sector in evenwicht' ('Balancing ...Read more
Minor Entrepreneurship: Startup Market
4 Oct 2016
On Thursday 6 October 24 student startups will present their product and business during the 'Minor Entrepreneurship Startup Market'.Read more
ABS researcher to speak at European Crowdfunding Convention
4 Oct 2016
Liang Zhao, a PhD researcher in the Amsterdam Business School's Entrepreneurship and Innovation section, has been invited to speak at the upcoming European Crowdfunding Network Convention on 3-4 November in Paris.Read more
Arnoud Boot (UvA) appointed Chairman of the European Finance Association per January 2017
16 Sept 2016
At the Annual Meeting of the European Finance Association (EFA) in Oslo last month, Arnoud Boot (University of Amsterdam/Amsterdam Center for Law & Economics) was appointed as Chairman of the EFA per 1 January 2017. ...Read more
UvA Economics and Business obtains 'Triple Crown' status
15 Sept 2016
UvA Economics and Business' Amsterdam Business School (ABS) has been accredited by the Association of MBAs (AMBA). This means UvA Economics and Business has officially acquired triple crown status.Read more
Willemijn van Dolen appointed as member of the AFM Supervisory Board
6 Sept 2016
Dutch Minister of Finance Jeroen Dijsselbloem appointed Willemijn van Dolen, professor of Marketing at the Amsterdam Business School, a member of the Supervisory Board of the Netherlands Authority for the Financial ...Read more
UvA Economics and Business launches new a Master in Finance and a revamped Master in Business Economics
2 Sept 2016
Starting 1 September the Amsterdam Business School of UvA Economics and Business will offer a new Master's programme in Finance with four specialisations tracks. The revamped MSc Business Economics will continue with ...Read more
Why and how does a RA acquire RE knowledge?
12 July 2016
It is possible for Register Accountants (RA's) to complete an abbreviated RE programme at the Amsterdam Business School (UvA). NOREA, the professional association for IT-auditors in the Netherlands has accredited ...Read more
Winners of the minor in Entrepreneurship Start-up Pitch Finale
8 July 2016
This past semester students in the UvA minor in Entrepreneurship, a collaboration of the Amsterdam Business School, Amsterdam Center for Entrepreneurship (ACE) and ACE Venture Lab, developed promising start-ups. On ...Read more


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Jan 30
From the early days of dating B, it was beyond clear that if our relationship was going to progress, HE would be the better chef in our family. I love to cook and I think I'm okay at it, but B is INCREDIBLE. Cooking is like art to him–he loves to research, mix and match, and work to come up with something amazing. I tend to stick to a recipe, where B looks at a recipe and says, "How can we make this even better?"
Needless to say, cooking a meal for him is slightly intimidating.
Monday night, I had my biggest cooking fail in our marriage. I set out to make turkey meatloaf muffins, but realizing I had forgotten the eggs, I had to improvise and attempted to make a "Mexican Ground Turkey Quinoa Bake" I stumbled upon in Pinterest. Not only did it not look appetizing, but it tasted bland and yucky.
In an attempt to salvage the debacle that was our dinner, I went for three instant upgrades: oil, cheese, and corn tortillas. I transformed the "quinoa bake" into quesadillas, and I will say on a scale of 1 to 10, our dinner jumped from a 1.5 to a 5–not too shabby!
Still, we were left with tons of leftovers that none of us, including Little B, wanted to go near.
In an attempt to be resourceful and salvage the quinoa bake, yet again, yesterday I decided to transform them into enchiladas.
I googled "simple enchilada red sauce" and stumbled upon a quick and easy recipe to whip up a sauce to hopefully add some flavor.
I then proceeded to layer the sauce, tortillas, quinoa bake, and cheese until the dish was full.
I put it in the oven for 25 minutes and waited…
At long last, after three attempts, I FINALLY had a dish that we could fully enjoy eating and even look forward to eating again. (Note: cooking anything with quinoa leaves you with leftovers for days)
I don't know about you, but I hate to fail. Let's be honest, who doesn't?
Often failure paralyzes me, causing me to retreat and hide, afraid to try again.
For me, this little escapade in the kitchen was a tiny reminder that sometimes, we're not going to get the results we're hoping for on the first try, but even when we fail, we can't be afraid to get up and try again. We need to be willing to keep trying, get creative, and think outside the box. Just because your first attempt is a total bust, does not mean everything is over.
The end-result might look different than we initially expected, but we will only enjoy and appreciate it that much more!
Do you not know that in a race all the runners run, but only one gets the prize? Run in such a way as to get the prize.
1 Corinthians 9:24


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NHS management in Scotland of GP prescribing has improved
The NHS in Scotland has improved how it manages prescribing in general practice during a period when it has faced considerable pressures. Spending on drugs has fallen in real terms over the past seven years despite the volume of prescriptions rising significantly.
GP prescribing accounts for 70 per cent of all NHS spending on drugs in Scotland. This amounts to almost £1 billion a year. Audit Scotland has today published Prescribing in general practice in Scotland, its third report on the subject.
The report says the health service has improved its management of GP prescribing, and family doctors are getting more support and guidance on their prescribing. Spending fell by 11 per cent in real terms between 2004 and 2011, despite the volume of prescriptions rising by a third during that time.
The report says there is scope for further improvements and potential to save up to £26 million a year without affecting patient care. This could mostly be done through reducing waste and cutting the use of less suitable medicines.
Auditor General for Scotland, Caroline Gardner, said:
'Most people in Scotland get a prescription from their family doctor at some point to treat or prevent an illness or help sustain a good quality of life. The NHS spends almost £1 billion a year on drugs prescribed in general practice. Since we last looked at GP prescribing, the volume of drugs prescribed has continued to rise but the NHS has significantly improved how it manages spending. This was during a period when there have been considerable pressures and constraints on the health service.
'It has achieved this through providing doctors with more support and guidance and using better information about what GPs are prescribing. Demand for prescriptions is likely to increase further and it's important that the NHS continues to work with GPs to make sure patients get the drugs they need and spending is well managed.'
The health service now has better quality information on GPs' prescribing than in the past. The report recommends NHS boards use this to target areas for further improvement, such as identifying where particular drugs are over- or under-prescribed and supporting GPs to review patients who take a number of different medicines.
In coming years a number of factors will affect prescribing and its associated spending, and it is difficult to forecast and quantify their long-term impact. These factors include new medicines and cheaper versions of existing drugs becoming available, Scotland's ageing population, and lifestyle issues such as obesity, smoking and alcohol misuse and associated illnesses. The unclear long-term picture means it is important the NHS continues supporting cost-effective prescribing to get the most from the significant investment.


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jeans: h&m top: primark sunglasses: façonnable
I only had a 3 hour Spanish exam today, (which I finished within an hour and a half, yay for that!) so I wanted to wear something comfortable but still nice. Now I am still very much in love with my ripped boyfriend-like jeans, but I just can't find the perfect tops to wear with them! Whatever I wear, I always feel like I look like I shrunk 10cm. Obviously, wearing them with heels would be one option, but since I'm not too keen about wearing heels in daily life, I'd like to find other ways to lenghten my apperance. This is where I'm going to ask you guys, do you have any ideas on what to wear with this kind of pants best? I might even go ahead and google it, hmm..


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Research Center of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zhejiang University, Hangzhou, China
Received date: February 23, 2014; Accepted date: February 24, 2014; Published date: February 26, 2014
Citation: Shihua W (2014) Targeting Aromatase and Estrogen Signaling for Breast Cancer. J Nanomedine Biotherapeutic Discov 4:e128. doi:10.4172/2155-983X.1000e128
Copyright: © 2014 Shihua W. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Journal of Nanomedicine & Biotherapeutic Discovery
Although there are significant advancements in human health prevention and treatment, breast cancer is still the most frequently diagnosed form of cancer and is the second leading cause of death for women [1], particularly in western countries. About 75% of breast cancers are positive for the estrogen receptor (ER) and/or progesterone receptor (PR) [2,3]. Estrogen, which acts through the estrogen receptor alpha (ERα), is the major stimulus in both pre- and postmenopausal patients who exhibit hormone-dependent breast cancer [3,4].
Generally speaking, estrogen is synthesized from cholesterol in a multiple-step biosynthetic process [5,6]. This process is regulated by aromatase, a key enzyme involved in aromatization of C19 androgen precursors such as androstenedione and testosterone into estrogens [7,8]. As shown in Figure 1, aromatase first converts the androgenic substrates androstenedione and testosterone to estrogens: estrone and estradiol (E2), respectively. and then these produced fat-soluble estrogens diffuse through the plasma membrane and bind to the ERα; hence,leading to the dissociation of heat shock proteins and dimerization of the receptor [3]. This conformation change allows ERα to be phosphorylated at several serine residues within its N-terminal domain. The receptor dimer then translocates to the nucleus and binds to the estrogen response element (ERE) located upstream of the proximal TATA box. ERα then recruits coactivators such as steroid receptor coactivator-1 (SRC-1), amplified in breast cancer-1 (AIB-1), and cAMP response element bind (CREB) protein (CBP). This allows activation of estrogen-responsive genes such as progesterone receptor (PgR), pS2, cyclin D1 and c-myc. These events lead to cell cycle entry and progression [3,9]. Therefore, deprivation of estrogenic signaling pathways has been the main and key therapeutic form of hormonal therapy for patients with ER-positive and/or PR-positive disease [10].
There are three main approaches to the deprivation of estrogenic signaling pathway. One approach is to affect the supply of estrogen to the breast tumor by surgical procedures such as oophorectomy, adrenalectomy, and even hypophysectomy. Oophorectomy was first suggested by George Beatson for the treatment of metastatic breast cancer more than 100 years ago [11]. These surgical procedures have demonstrated efficacy and survival benefit for women with advanced breast cancer by reducing systemic estrogens. However, because these procedures are irreversible and are associated with potential morbidity and mortality, pharmacological means of estrogen inhibition remains as the primary method of treatment [8].
The second approach is to counteract the effects of estrogen by blocking the estrogen activity at the receptor level. This is typically performed by targeting ER using the selective estrogen receptor modulators (SERMs) [12]. The first pioneer of the SERM drugs is tamoxifen, which has been used to block the binding of estrogen to its receptor by the competitive inhibition of the ER [13]. For the past three decades, tamoxifen has been the standard for prevention and for adjuvant and first line metastatic therapy in women with hormoneresponsive breast cancer [8].
The third approach is to inhibit the production of estrogen. Due to key role of aromatase in the biosynthesis of estrogens from the androgen precursors (Figure 1), aromatase inhibitors and inactivators may represent interesting options in this setting in spite of the fact that SERMs are currently being approved for breast cancer prevention in several countries [7,14]. There is an increasing interesting on inhibiting aromatase enzyme expression or activity to reduce the estrogen production to achieve an endocrine response in ER-positive breast cancer.
Both experimental and clinical data show that aromatase inhibitors, in ER-positive breast cancer, achieve greater response compared with the non-steroidal ER antagonist tamoxifen. This difference might be related to the partial agonist effects of tamoxifen, which limits its clinical effectiveness. Clinical trials have confirmed that aromatase inhibitors are more effective and better tolerated than tamoxifen in postmenopausal women with early or advanced ER-positive breast cancer [15-17]. Hence, aromatase inhibitors are set to replace tamoxifen as the standard of care for these patients [7].
Throughout the years, a large numbers of aromatase inhibitors have been developed and have been available for clinical and preclinical therapy, specifically for ER-positive breast cancer patients. Currently, in the United States, there are three-generation aromatase inhibitors including type I steroidal aromatase inactivators and type II non-steroidal inhibitors, which have been approved by the FDA for the treatment of ER-positive breast cancer [7,8,18,19] (Figure 2). Aminoglutetimide, a first-generation aromatase inhibitor, was first introduced in the 1970s for the second-line treatment of advanced breast cancer; however, its use was limited due to its toxicity and its lack of selectivity towards the aromatase enzyme. The second- (formestane and fadrozole) and third-generation (exemestane, anastrozole, letrozole) aromatase inhibitors have a lower overall toxicity and higher degree of selectivity towards the aromatase enzyme. Unlike the first- and second-generation aromatase inhibitors, the third-generation inhibitors have a greater oral bioavailability and are available as one dose per day [8,18].
Figure 2: Reprehensive aromatase inhibitors: the first (1), second (2), and the third-generation aromatase inhibitors (3). Among the listed aromatase inhibitors, formestane and exemestane (circled) are irreversible steroidal aromatase inhibitors (Steroidal inactivators), whereas the others are nonsteroidal reversible aromatase inhibitors (Non-steroidal inhibitor).
Recently, a phase III trial showed that exemestane reduced the risk of developing breast cancer in high-risk, postmenopausal women [20]. This is the first evidence that an aromatase inhibitor reduces the risk of a breast cancer, and it leads to exemestane becoming an option for high-risk, postmenopausal women [21]. In addition, exemestane exhibits weak agonistic activity towardsERα; thus, this eliminates some side effects associated with aromatase inhibition such as the loss in bone mineral density (BMD) and increase in bone fracture rates [22].
Besides the developed synthetic aromatase inhibitors [18,19], natural aromatase inhibitors is an attracting option for many people and also researchers alike [23,24]. Currently, many natural products have been found to possess aromatase inhibitory activity. Typically, flavonoid compounds such as flavones, flavanols, flavanones, flavonols and isoflavones exhibit a steroidal structure and they are the most common natural aromatase inhibitors [23,24]. Other natural aromatase inhibitors include: coumarins, lignans, stilbenoid, anthraquinones, diterpenoids, steroids, triterpenoids, alkaloids and peptides [23,24].
Despite these synthetic and natural aromatase inhibitors improved preclinical and clinical outcome, in both the adjuvant and metastatic setting for postmenopausal women with breast cancer [8], their inefficient systemic delivery, poor solubility and bioavailability have severely limited their use. In addition, these drug candidates undergo fast oxidation under basic conditions and first pass metabolism before reaching to systemic circulation. Thus, novel strategies are needed to enhance the bioavailability and reduced perceive toxicity associated with the long-term use [25].
In the last few decades, nanotechnology had an enormous impact on medical technology, significantly improving the performance of drugs in terms of efficacy, safety and patient compliance. Nanotechnology manifests wide range of materials which can be smartly designed with chemically modifiable surfaces to tag variety of chemical, molecular and biological entities. Modulation of surface properties offers advantageous properties like increased solubility and biocompatibility. Nanoscale materials and devices with unique therapeutic properties can be engineered to deeply infiltrate tumors with a high level of specificity [26]. Drug-loaded polymer nanoparticles or micelles are promising drug delivery systems for the treatment of severe diseases including cancer. Attaching polymers such as polyethyleneglycol (PEG), polyvinylpryrrolione and ployvinylaclcohol increase the solubility and provide protection to the degradation of proteins during in vivo applications. Encapsulation in nanoparticles allows the drug to be protected from destabilization and/or rapid clearance from the body, while protecting healthy tissues from the drug's inherent cytotoxicity. Another strategies, derived from the prodrug concept, also wide use to alleviate some of drabakcs witnessed with polymeric nanoparticulate systems. Drugs have been covalently linked to preformed amphiphilic copolymers, leading to a sustained anticancer drug release from the nanoparticles by hydrolysis [27].
For instance, PLGA nanoparticles in enhancing the tumor uptake of letrozole [28], hyaluronic acid-bound letrozole nanoparticles restore sensitivity to letrozole-resistant xenograft tumors in mice [29]. Targeted delivery [30] and combination therapy [31] can drastically improve the intracellular retention and transcytosis of drugs across the epithelial and endothelial barriers.


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Roll damping and pitch damping by RotorSwing Marine
Roll damping and pitch damping by RotorSwing Marine is now offered to smaller yachts starting at 12 meters (38').
RotorSwing Marine works closely together with Quantum Controls Holland, who are the manufacturers of the Maglift systems for mega yachts (the big brother of the RotorSwing Magnus). They have over 30 years of knowledge in yacht stabilizers based around the Magnus effect. RotorSwing now also offers the WING Yacht Stabilizers for roll damping and pitch damping for faster yachts.
If you are looking for roll damping, pitch damping, or stabilization while at anchor, take the first step to stabilize your vessel by emailing us, calling us or by simply filling in the contact form below.
RotorSwing Marine Holland
Schuttersstraat 26B
The Netherlands
Telephone NL: +31(0)46.423.42.06
E-mail: email@example.com
RotorSwing Marine USA
Telephone US: 480.862.3533
E-mail: email@example.com
RotorSwing Marine England
Telephone US: +44 (0)1481 726 267
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text: Hi! This is easy method i found out few hours ago and im starting getting cash now. It's really simple: go to this: http://www.blackhatworld.com/blackhat-seo/youtube/489779-method-20k-views-5-minutes-work.html thread and follow instructions to get 20k credits at u2bviews. All tools you will need: "easy hide ip" (3 days trial and then uninstall with revo uninstaller and get another trial) and "ccleaner" (free). You can also get some spinning software to make one spun comment and use it multiple times. Just clear your browsing data with ccleaner and get new ip with easy hide ip. Create youtube account (you may pucharse some, you can get 100 youtube phone verified accounts at BST for 25$) and post comment (read below what kind of) at some popular video. Then go to u2bviews and add 15 thumbs up to your comment and wait for traffic coming in. Comment: it has to look natural and promote some offer (for example cpa). Pick some offer that you can find videos releated to and write a comment like you would be responding someone like: "@andrew124 sure, you can get an iphone for free. You just have to enter some contests and have some luck. For example you can get it here: {your "get free iphone" cpa link} Good luck" That's all. Post more comments every day and watch more traffic and money coming in every day. Good luck! PS: feel free to ask any quesions here but please don't pm me about this method. Thanks


text:
Photon Netw Commun (2016) 31:183–185
DOI 10.1007/s11107-016-0626-3
Optical networks special issue based on selected IEEE ICOCN
2014 papers
Gangxiang Shen
· Calvin C. K. Chan
· Jie Zhang
· Jason P. Jue
Published online: 5 April 2016
© Springer Science+Business Media New York 2016
The 13th International Conference on Optical Communica-
tions and Networks—IEEE ICOCN 2014 (http://www.ontrc.
org/icocn/) was held in Suzhou on November 9–10, 2014.
IEEE ICOCN aims to provide a premier opportunity for
professionals, experts, engineers, scientists, and industrial
people worldwide in the field of research, development, and
applications of photonics to share and exchange their expe-
rience. IEEE ICOCN 2014 included three technical tracks:
(1) optical networks, (2) optical transmission subsystems and
techniques, and (3) photonic devices and integration.
IEEE ICOCN 2014 was a two-day event organized by
Optical Network Technology Research Center (ONTRC) in
School of Electronic and Information Engineering, Soochow
University. IEEE ICOCN 2014 was technically sponsored
by IEEE Photonics Society. The conference was also sup-
ported by National Natural Science Foundation of China
(NSFC), Zhongtian Broadband Technology, Electronic Insti-
tute of Suzhou, and the City Government of Suzhou.
We accepted more than 120 papers by the authors from
more than 13 countries and regions, among which 59 are
invited talks. All the papers were carefully reviewed by more
than 30 Technical Program Committee (TPC) members and
external reviewers, with each paper evaluated by at least two
Gangxiang Shen
Soochow University, Suzhou 215006,
People's Republic of China
The Chinese University of Hong Kong, Shatin, N.T.,
Hong Kong
Beijing University of Posts and Telecommunications,
Beijing 100876, People's Republic of China
The University of Texas at Dallas, 800 West Campbell Road,
EC 31, Richardson, TX 75080-3021, USA
reviewers. All these papers and talks are organized into eight
lecture-style oral sessions and one interactive poster session.
Based on the comments received from the reviewers, the
authors of nine accepted papers that are in the area of opti-
cal networks were invited to submit an extended version of
their work for possible publication in this Optical Networks
Special Issue of the Springer Photonic Network Communica-
tions (PNET) journal. After a thorough review process, eight
papers have been selected for publication. In addition, this
Special Issue includes invited papers that went through the
same review process of the other accepted papers. A brief
summary on the accepted papers is provided next.
In "Backup Reprovisioning with Partial Protection for
Disaster-Survivable Software-Defined Optical Networks," S.
S. Savas, C. Ma, M. Tornatore, and B. Mukherjee propose
a Backup Reprovisioning with Partial Protection (BRPP)
scheme supporting dedicated path protection, where backup
resources are reserved but not provisioned (as in shared-
path protection), such that the amount of bandwidth reserved
for backups as well as their routings is subject to dynamic
changes, given the network state, to increase utilization.
In "Optical Quorum Cycles for Efficient Communica-
tion," C. J. Kleinheksel and A. K. Somani propose to apply
the distributed efficiency of the quorum sets to route optical
cycles based on light-trails. With this new method of topology
construction, unicast and multicast communication requests
do not need to be known or even modeled a priori.
In "Correlation-based Virtual Machine Migration in
Dynamic Cloud Environments," L. Liu, S. Zheng, H. Yu, V.
Anand, and D. Xu establish a service level agreement (SLA)-
based soft migration mechanism to significantly reduce the
number of virtual machine (VM) migrations, and develop
two algorithms to solve the VM and server selection issues,
in which the correlation between the VMs and the servers is


text:
Scott Line is on a roll.
Line, a 15-year-old from Howey-in-the-Hills, was a double winner last week.
He won the Indigo Lakes Junior Invitational's boys 16-under division in Daytona Beach last Thursday by defeating Mike Braunstein of Ormond Beach in the finals, 6-4, 6-1. Line proved it wasn't a fluke by winning the Central Florida Summer Classic at the Orlando Tennis Center Sunday, again defeating Braunstein, 6-3, 6-4.


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The tadpoles are taking too long to develop their little bodies, which is making the frogs crazy and thinking that they should do something about it. With a special cannon, they need your help to crush the ones that look the same, so they can match and release their sons.
use your mouse to play.


text:
The Wardrobe: For the love of Prints
Lately I really enjoy mixing prints! I find it so much fun to pair different shapes and colors and create interesting outfits. With this one here I went all out by pairing a full printed skirt with a top that already has a mix of prints on it's own! I didn't hesitate whether I should wear these two for a moment! The muted, earth tones make the outfit settle, the light fabrics give it the perfect dose of femininity I need and the prints make it interesting without being too much out there or annoying for the eye.
Skirt: Made by me / Top: Made by my mom / Purse: Handmade / Bracelets: Vintage / Ballerinas, Sunnies & Feather earring: H&M
Do you follow any rules when mixing prints?