text:
Hello Readers!
I am just back from my virgin trip to Bali!
From our friends, Mrs SOL and I have heard good review about the beautiful beaches, resorts and even food that Bali has to offer. Therefore, we have been so looking forward to this trip since the day we booked our air tickets online.
Batam or Bali?
Bali indeed is a beautiful island and a beach-lover paradise. If you were to ask me to compare Bali to Batam based on my own experience, I would say Bali is more commercialised and touristy whereas Batam is more laid back and simple. To put it simply, I would like to put it this way:
1. Batam – Ideal for a short getaway. Family and friends' retreat. Price is reasonable.
2. Bali – A comprehensive holiday (4 to 7 days), Honeymoon, graduation trips etc. Prices are expensive.
We love Bali!
Ok let's go back to Bali. Although it is an island, but it is much larger than you can imagine.
Among Singaporeans and beach lovers, the popular spots will be Seminyak and Nusa Dua. Both areas can offer you a beautiful beach with famous resorts that you can sojourn in.
As for the rest not to worry, you can find yourself immerse in Balinese arts and culture in Ubud. For scenic seeker, you can visit Tanan Lot and Desa Candikuning.
Arrival in Ngurah Rai Airport
Frankly speaking, initially, I did not expect much for an Indonesia's airport. However, Nguarah Rai international airport changed this impression of mine, and I must comment that I was quite impressed with the layout of the airport and how it can provide a comfortable experience for the tourist despite much of the place is still having work in progress. I believe once they get the airport to be fully renovated, it will be able to provide tourists a greater premium feel, by having more shops and facilities opened for everyone.
I would like to advise all readers who are planning to visit Bali especially on a free and easy trip, to get a prepaid card in the airport. Once you have done with the passport and luggage check, you will walk to the arrival hall where you will see local drivers holding cards with names on it, seeking for their guest. At this hall, spot for a small counter located on the right just before you enter the DFS shopping. They are selling the card for Rup. 200,000 and this gives you 3.5 gb of data and 95,000 worth of calling credits.
You will find this card useful when you are trying to navigate your way, looking for any place of interest nearby. You will also find it handy when you need to call your driver/ tour agency to book a tour, etc. and yet not incurring a large amount of roaming calls charges.
IZE Seminyak Hotel
Traffic condition in Bali is quite bad. Somehow it will make you appreciate the COE bidding system in Singapore. The travelling speed can ranges from moving very slowly to not moving for a couple of minutes now and then. Seldom, you can drive more than 70km/hr especially during the narrow roads in Seminyak area.
Because of the traffic condition, the journey took us 1 hour to reach IZE Seminyak hotel from the airport, which according to Google map, it is 12 km apart, supposedly estimated to be just a 15 minutes drive.
It was quite a pain for both of us to endure the jerky ride. The good thing was that we were greeted by the friendly staff of IZE Seminyak when we arrived.
1. Location
IZE Seminyak markets itself as a chic and modern hotel, located strategically in the action of all the happening pubs and restaurants, and also in the heart of the lively and fashionable street of Seminyak. Indeed, they lived up to their promise, the location of this hotel is fantastic. Once you exit from the hotel, you will find yourself surrounded by restaurants and retail stores.
2. Room
The room we booked was the simplest – deluxe room. There are various other options that you can choose from such as a deluxe room with Jacuzzi, deluxe room pool (come with a separate swimming pool exclusive to all deluxe pool guest), club room and club suite.
For our stay, Mrs SOL and I had decided that a deluxe room will be sufficient as we will be spending most of our time outdoors. Therefore, we just need a comfy room for us to lodge in, to retire after each eventful day will be sufficed. Furthermore, we booked another accommodation for our second last day in Bali (which I will do a review with later subsequent post too~), which cost a bit higher than IZE Seminyak for its more resort setting (near to the beach, secluded and peaceful).
3. Facilities
Although being a relatively small hotel compare to those villas and resorts, it still has the necessary facilities cater to the general tourist which are Gym, Restaurant and a rooftop pool. What I felt IZE Seminyak is lacking is a spa salon although they do provide a free transport service to their sister hotel, The Amala, for spa treatments and related services.
4. Breakfast
Breakfast is something I felt IZE Seminyak could do better. Although they do provide limited selection of variety each day (on their buffet section offers local delights, breads and fruits), but your main dish (which you have to order with the staff on duty) remain the same for the 3 days that we stayed in there.
I would recommend IZE Seminyak if you decided to plan an economical trip. A deluxe room would probably cost you around SGD$130 per night, including breakfast and tax. This will save you quite a bit for your shopping, spa and massage expenses. It is situated in an ideal location, surrounded by retail shops and F&Bs.
However, do take note on the trade off for being surrounded by pubs. In the night, it will get a bit noisy (or happening if you like it) on the streets, which in your room you still can hear people singing and cars moving. The party can possible last till 1am! So if you are a light sleeper or you are a person who dislikes disturbance while you rest, you should really reconsider your choice.
Other than that, IZE Seminyak is definitely a good choice for the party lover, shopping addicts and beach lovers (15 min walk to the Seminyak beach).
That's all for part 1. Do stay tuned for part 2 in which I will share about our one day trip to Ubud. 🙂
IZE Seminyak Hotel
Jalan Kayu Aya (Laksmana – Oberoi) No. 68
Seminyak, Bali – Indonesia
Tel: +62-361 84 66 999
Fax: +62-361 84 66 988
Email: firstname.lastname@example.com
Website: www.ize-seminyak.com


text:
Stock and Shares – having mentioned them to quite a few people the usual response is, "Oh I'm not really sure about that, prefer to hold cash". I get it 100% – I wouldn't be pouring my money into something I didn't understand either. However, if that's you, you're missing out on the opportunity to make money two ways.
Now I'm sure most of us were told that we should save some money for a rainy day. Whether we do or not is another matter, however let's assume we do. So we go to work, earn money and save some money. As long as we have something set aside we should be alright surely? Possibly, but looking at the bigger picture we need to think about how our money will work for us over time.
If we want to be smart with our money and reach our goals – we need to get the most bang for our buck.
I have always set something aside from my salary even when earning a low income. Without any other financial safety net to fall back on it was essential to have some kind of emergency fund if that rainy day came.
Learning more about money increased my awareness of inflation. We all feel the effects, even if we don't know it by name.
Inflation= general increase in prices and fall in the purchasing value of money.
Older Millennials, like myself, will remember a time when a Snickers bar (my childhood go to chocolate bar) was 27p. Fast forward 15 years and that same bar is around 60p! Not only is that more than double the cost but the bar has shrunk in size (double blow!). This is inflation in action.
If we look at cash, £500 spent today will buy more than £500 spent in years to come.
If we assume inflation is around 2%, any interest on savings would need to be at least 2% to maintain its purchasing value (i.e. buy the same amount in future that it could buy today). You need an even higher interest rate to achieve a real return on your money.
Nonetheless cash does have its benefits – it's ready to use, therefore despite it not working so hard in the current climate, it serves a purpose. Be sure to hold some as your emergency fund.
Stocks & Shares
You can own a share of an individual company or invest in a fund that spreads its investments over multiple organisations (mutual fund).
I was late getting involved in stocks and shares. I'd never explored how and hadn't appreciated how they could help boost my financial position. As the saying goes, better late than never as the returns so far have well and truly exceeded inflation.
The journey with your investments won't all be one way. There will be downs as well as ups (as many who held portfolios during the Great Recession would testify). With the downs things may seem to get worse before they get better. The key is making regular investments.
"Be Fearful When Others Are Greedy and Greedy When Others Are Fearful" ― Warren Buffett
Think of purchases in down periods as a bargain sale in which you can pick up more units for less. Then enjoy the gains on these cheaper units when the market recovers. This is the complete opposite of what the most people do (buying when prices are high and selling low).
Time to get multiple baskets
As the saying goes don't put your eggs in one basket. Building wealth should involve different types of assets (e.g. cash, stocks/shares, property, business).
The average millionaire is said to have 7 streams of income. Why not have the same protection? As we all know jobs can go, value of currency can fall (think Brexit impact on GBP), interest rates can tumble…. you get the drift.
Make investing part of your financial journey.
For those in the UK you have the benefit of your stocks and shares ISA where gains are tax free. If you are still holding all your money in cash, take the leap into investing. You don't need huge amounts to get started. Start diversifying your income today!

subset: commoncrawl


text:
Ex-NYC cop pleads guilty to randomly firing 14 shots at car
WHITE PLAINS, N.Y. (AP) — A former New York Police Department officer pleaded guilty Tuesday to charges he randomly fired 14 shots into another car after downing 10 alcoholic beverages while off-duty.
Brendan Cronin, 28, pleaded guilty in Westchester County to attempted murder, assault and drunken driving in the April 29, 2014, shooting.
Prosecutors said Joseph Felice and Robert Borrelli were stopped at a red light in Pelham when Cronin started firing at them.
Felice was hit six times in the back, shoulder, arm and chest. The bullets missed Borrelli, who drove his friend to the hospital.
According to court documents, the 28-year-old Cronin told police he'd had 10 drinks of beer and whiskey before the shooting. He and fellow officers had gone out drinking after a day of training at a police shooting range.
The Yonkers resident is expected to be sentenced to nine years in state prison. Sentencing is scheduled for Sept. 29.
Felice and Borrelli have filed lawsuits against Cronin, New York City, the NYPD and the officers Cronin was drinking with.
Randolph McLaughlin, an attorney representing Felice and Borrelli, said they are relieved by Cronin's guilty plea and "look forward to the truth coming out in the course of the civil case."
Felice told The Journal News in an interview Monday that his life has been ruined by the shooting.
He said he can't lift his 5-year-old son and must rely on his wife to drive him to his job as a salesman.
Sorry we are not currently accepting comments on this article.


text:
Fridse 423 Sport2001 Stallion (Teunis 332 × Lolke Y)
|Teunis 332
|Lolke Y
|Nammen 308
Fridse was born in the Netherlands in 2001. After several years of breeding in the Netherlands he was imported to the USA where he stood at stud at Wish Upon A Ster Friesians (owner Steven Feys) through the 2011 breeding season. In December of 2011 Fridse was purchased in a partnership between Jim and Sally Bedeker and Louis and Julia Dorfman. The owners of Fridse have honored the Friesian Connection Stallion Station with the privilege of standing Fridse at stud.
Fridse is permanently approved on offspring. He is by the late, great Teunis 332 Preferent, and out of a Star mare who has also produced another KFPS approved stallion, Bente 412. Fridse has better than excellent KFPS test scores for his approval and his progeny test-offspring approval. The KFPS offspring judging resulted in comments regarding Fridse's impressive contribution to the breed with each foal he produces. The fact that, while in Holland and even after a late start to the 2005 breeding season (following the performance exam), Fridse bred the maximum number of mares clearly demonstrates the confidence breeders in Friesland had in this stallion.
During Fridse's progeny testing for permanent approval, two of the tested offspring earned above 80 on their IBOP tests. This was written up in the KFPS magazine (as well as on-line), as it was quite a remarkable accomplishment. Since then Fridse has had at least one daughter earn Crown status in Europe. Fridse's offspring most frequently achieve star status, more so than nearly any other stallion worldwide. His offspring foal scores and influence are off the charts, and when you have one Fridse baby --- you want another. They are personable, incredibly sweet natured and have a certain presence about them - a movie-star-like-confidence with a look at me showiness. Fridse foals are also correct in conformation and move incredibly well.


text:
The World Health Organization (WHO) recommends an average of 400g of fruits/vegetables daily for adults below 35years for good health. This translates to five servings of fruits and vegetables; potatoes, cassava and other tubers are excluded.
A recent study in India has shown that youths consume less of fruits/veggies, doing only about 3.5 servings daily due to pressure of work, tight schedules and the fact that they are always away from home. Also, the options for packaged fruits and vegetables are limited besides the knowledge that it is unhealthy to eat vegetables and fruits raw in India due to pesticides; they have to be thoroughly washed.
Consequently youths are more inclined to fast foods which are processed.
We all should endure to consume five servings or 400gs of fruits and veggies every day.


text:
- A little cute, a little creepy, but all awesome because it's a cat!
- Can totally trick your guests into thinking this is an actual cat with its real image print
- Fuzzy cats are the best ones. What's better? One that you don't need a litter box forCats - Don't we all love them? This Gray Cat Doorstop fits in perfectly well to a cozy little home. It looks adorable and even holds doors open for you - So long as you make sure to move it to where you need it to be..
- Description
- Reviews
- Shipping Information
If you're not so much a fan for pretty little gray cat, doorstops - You have a friend or family member who is! Show them some love and gift to them this Gray Cat Doorstop.
Gray Cat - Doorstop Features:
- Material: Cotton, Buckwheat
- Size: 9.5"L x 4"W x 12"
Customer Reviews
Shipping came a day early. Couldn't have asked for a better result. Thanks
For domestic (Contiguous US states) orders we now offer FREE Shipping on any order above $35 (after any discount and promotion has been applied, and before taxes and shipping).
While free shipping is great and cost effective, we realize that sometimes our customers only need fewer items. We therefore offer a low flat fee of $5 for Economy Shipping (5-10 Business Days) within the Contiguous US States) for all those orders that are not within the $35 threshold.
In most cases, we use USPS, FEDEX or UPS services to ship your order. Orders generally ship within 24 hours. Delivery time varies according to your choice of shipping method at checkout. Once your order ships, you will receive a shipping confirmation email with a tracking number so that you can follow the package wherever it is :).
IMPORTANT: Please be advised that some of the products are shipped directly by and from our manufacturers and may take slightly longer than the above mentioned times.
Your satisfaction is important to us. We offer a 30 Day Guarantee Return Policy. If you are not happy with your purchase, just return it in new condition for a refund/replacement. Please review our Return Policy for more details. Terms and Conditions may apply.


text:
Buttercream Frosting
- Total Time: 10 mins
- Hands-on Time: 10 mins
- Makes: 10 servings
An American classic, buttercream frosting features five simple ingredients to achieve the familiar flavor we all know and love. This simple lip-smacking recipe is one for the recipe box.
featured ingredient:
Frontier Organic Vanilla Extract 2 fl. oz.view product
- 1 teaspoon Frontier Organic Vanilla Extract 2 fl. oz.
- 1 dash Frontier Table Grind Sea Salt 5 lb
- 3 teaspoons butter
- 1/4 cup milk (more if needed)
- 2 cups powdered sugar
Place all ingredients in a mixing bowl and beat with an electric mixer until fluffy.
For chocolate buttercream frosting, add 2 squares (2 ounces) unsweetened chocolate, melted.
Calories: 130
Share your voice with our growing community!
Create an account and join our conversation. See our Community Guidelines.
Create an account and join our conversation. See our Community Guidelines.
No reviews have been submitted for this entry yet.
Please wait...


text:
Curly Maple Bullet style pen
These bolt action bullet pens are great gifts for the outdoors person.
They write great as well. Have a look on the Knots to Bowls website to see more like this handcrafted pen made with wood from Ontario, Canada.
The Mini bolt action style pen is new. There only 4inch's long.
The Making of a Wood Bowl
How Wooden Bowls Are Made – Step By Step
Visit Us at Knots to Bowls for more handcrafted wood products.
Need a Hand?
These days it's all about healthy eating and that means more greens, more salads. Gone are the days of a chunk of iceberg lettuce slathered with dressing. Today's salads are culinary works of art, colorful and enticing. What goes in them is limited only by your personal preferences and imagination. Whether a meal or a side, salads are playing a new role in our eating experience.
Presentation has much to do with the appeal of any food and that includes salads. With a lovely handcrafted wood bowl as the background the variety of colors in the salad pop and make the viewer want to dig in. Dig in how? There are numerous utensils designed to serve the salad, from plastic to high dollar gold plate. The regular servers have difficulty getting the small pieces, like onions or capers or sunflower seeds.
Salad hands to the rescue! They scoop the lettuce and keep the small pieces in place giving you the full benefit of all the goodies in the salad. They even come with a 'knobbie' that hooks over the edge of the bowl so the hands are readily available to serve. Salad hands come in different styles and wood types and are easy to care for. There's just no reason to serve a spectacular salad without a pair of hands to help out.
Heart Healthy Salad
2 tablespoons extra-virgin olive oil
2 tablespoons sherry vinegar
2 teaspoons Dijon mustard
1/4 teaspoon salt
1/4 teaspoon sugar
1/4 teaspoon freshly ground black pepper
1 (10-ounce) package gourmet salad greens
1/4 cup finely chopped dried apricots
1/4 cup chopped pistachios
1. To prepare dressing, combine all ingredients in a small bowl; stir with a whisk.
2. To prepare salad, combine all ingredients in a large bowl; add dressing.
Recipe from http://www.myrecipes.com/
Cheese Board Set
Rustic look extra thick cheese board made with curly maple, also a cheese planer and a cheese pick with cherry handles.
Your Favorite Handcrafted Pen
What kind of pens do you like the most, Ballpoints, Rollerballs or when was the last time you have tried a fountain pen?
I'm not the greatest writer but I like the rollerballs the best, they seem to just fly along the paper.
I have asked some people that really write good and most say they love their ball points.
I sure did love the wood I used with this rollerball pen.


text:
Top Ten Things Sports Fans Wear
Written by: Catalogs.com Editorial Staff
April 17, 2011
Filed Under Sports
Contributed by Tim Brugger, Catalogs.com Top 10 Guru
Sports fans love their teams, and there is a method to dressing in support of your team, whether you are watching the game at the stadium or in your man cave.
Colors are important, team jerseys essential and having enough spirit to go all out makes you a fan above the rest. Here are the top ten things sports fans wear. Be inspired:
10. Face paint
While many of us may not have the gumption to paint our face to match our team's colors, here's a quick shout out for those that do. I can only assume there are special face paints for this kind of thing; if not, it's going to be a long week at the office.
9. Authentic team jersey
Tried and true, there's no better way to show support than slapping on your team's jersey the day of the game. Of course, if things don't go well it can be a long drive home, but that's a chance we're willing to take. Win or lose, we have our team jersey and we're standing proud, dang it!
8. Body suit
Scary yes, but you've got to hand it to 'em. Anyone with the nerve to wear a spandex-like full body suit to a sporting event warrants a certain measure of respect. Well, maybe not respect, but at least dumb-struck admiration.
7. Chest painting to spell names
This certainly belongs on a Top Ten list of sports wear, if for no other reason than it promotes camaraderie. Pulling this one off requires several people, all of the same ilk, and precise seating arrangements. One quick trip to the restroom, and the whole group suffers. Now that's sacrifice.
6. Foam finger
Cheesy? Yes. But if you've ever been in a stadium packed full of people waving their over-sized foam fingers proclaiming "We Are Number One!" loud and proud, you know why The Finger has made the list. Not quite awe-inspiring, but a spectacle nonetheless.
And if a standard foam finger isn't big enough to show your team spirit, consider a full body custom foam finger! Now THAT'S spirit!
5. Headgear
Not the kind of headgear your Mom forced you to make certain the expensive teeth-straightening procedure took. No, this refers to the myriad of headgear options you see sports fans across the globe don on gameday. Green Bay has their cheeseheads, Pittsburgh their hard hats and Chicago their old-school, faux leather helmets, to name but a few.
4. Kids team outfits
What better way to make sporting events a day of family frivolity than getting the youngsters involved with miniature jerseys and cheerleading outfits. This actually serves a dual purpose; one is the aforementioned family fun, the other is you are less likely to get harassed by the opposing team's fans when there are kids around. Cheer together, and avoid instigating a riot, a perfect combination.
3. Old school jersey
Sporting your team's jersey, Top Ten list #9, is undoubtedly a step in the right direction. Going old school takes jersey-wearing to an entirely different level. You've immediately differentiated yourself, saying to the masses "don't talk to me about bandwagons; I've been following my team since the advent of radio."
2. Nothing (or very little anyway)
Wearing little or nothing to a sporting event instantly sets you apart, doing so when its 14 degrees below zero should earn you the right to free beer throughout the contest; and that includes overtime. Though, if you're cheering on your team while close to naked in the freezing cold, there's a good chance additional beers will do more harm than good.
1. Team jewelry
Sports fans – real fans – live, breathe, and dress their team spirit, even when it's not game day. Team logo jewlery, from necklaces and bracelets, to handsome sports cufflinks for him, are a great way to add a touch of "go team" to work and meetings.


text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Steve Lewis <lordjoe2...@gmail.com>
|Re: I need help building Hadoop 2.0 for windows
|Fri, 17 Jan 2014 02:41:23 GMT
1) I have included the text when I build as described in the document 2) I included my patches to a couple of files in the hadoop jars which fix issues - essentially Hadoop tries to set permissions which I find is really unneeded under Windows and the fix is not to do that if running under windows. I add these to my project earlier in the classpath than the standard Hadoop jars and things run well without needing winutils.exe or hadoop.dll 3) The real issue is that my experience is that jobs need to be debugged in single node mode on a local machine before testing on the cluster. There are issues which only emerge on the cluster but most of the logic can be tested with the support of good debugging tools on a single machine. 4) A larger issue may be that on the cluster bash calls are handled by forking. If Hadoop jobs require significant memory, mine need 2-3 gb, the fork requires the same memory and I get failures when multiple jobs fork at the same time. These failures are not repeatable but if jobs are large enough there is a significant probability the job fails when a failure happens 3 times. A good long term fix is to use a small server on the slaves to handle bash callouts. On Thu, Jan 16, 2014 at 10:00 AM, Chris Nauroth <firstname.lastname@example.com>wrote: > Steve, I'm responding to your email from 1/6/2014 asking for help with > building on Windows. > > > http://mail-archives.apache.org/mod_mbox/hadoop-mapreduce-user/201401.mbox/%3CCALEj8ePTj6hZjqA%3D8sVG6J-%2BvMOYNn15vcYv1aAA%3DYhP-gKLwQ%40mail.gmail.com%3E > > I lost the original thread, so I'm pasting the full contents from the > archived message below. > > Sorry that this isn't available as a binary distribution yet. That's > definitely a TODO. > > It sounds like you've already followed the instructions in BUILDING.txt > and had a successful build for winutils.exe, but not hadoop.dll. Can you > provide more details about the problem you're seeing with the hadoop.dll > build? > > Chris Nauroth > Hortonworks > http://hortonworks.com/ > > I usually run Hadoop on a linux cluster but do most of my development in > single machine mode under windows. > This was fairly straightforward for 0.2. For 1.0 I needed to copy and fix > FileUtils but for 2.0 I am expected to build 2 files from source - > WinUtils.exe and hadoop.dll. There is really only ONE serious windows > configuration: 64 bit intel and NO good reason why these files could not be > available in a binary distribution - > Is anyone using Hadoop 2.X and developing under windows whi can help. > My configuration builds WunUtils.exe but not hadoop.dll and fails trying to > set permission on a staging > file file:/tmp/hadoop-Steve/mapred/staging/Steve2116067144/.staging > > I could use help and advice > > -- > Steven M. Lewis PhD > 4221 105th Ave NE > Kirkland, WA 98033 > 206-384-1340 (cell) > Skype lordjoe_com > > > > CONFIDENTIALITY NOTICE > NOTICE: This message is intended for the use of the individual or entity > to which it is addressed and may contain information that is confidential, > privileged and exempt from disclosure under applicable law. If the reader > of this message is not the intended recipient, you are hereby notified that > any printing, copying, dissemination, distribution, disclosure or > forwarding of this communication is strictly prohibited. If you have > received this communication in error, please contact the sender immediately > and delete it from your system. Thank You. -- Steven M. Lewis PhD 4221 105th Ave NE Kirkland, WA 98033 206-384-1340 (cell) Skype lordjoe_com
|View raw message


text:
Fundación Punta de Mita invites you to their FAIR 2015! – The Photos!
26. March, 2015 by Tere Events, Community Comment this Article →
Fundación Punta de Mita celebrated a fantastic community strengthening and fundraising event benefiting the Punta de Mita Sports Center this past Saturday, March 28th.
With this event, Fundación Punta de Mita reunited all the sectors of the community, inviting those who live in and visit Punta Mita, the inhabitants of the surrounding towns, and the businesses of the region. Each one is an important part of the life in this region and, in one way or another, all benefit from the Sports Center.
Additionally to reuniting the entire community in a fun event, the foundation was looking to raise funds for the Sports Center Punta de Mita, and at the same time generate an awareness of the maintenance needs of the Sports Center. This location has become an important community space and an attraction, not only in Punta de Mita, but for the entire north side of the bay. The Sports Center facilities benefit hundreds of people each week through various physical activity classes, space for training, and sports gatherings.
The funds raised from this event will be used directly for the daily maintenance and upkeep of the sports center, the instructors' salaries, and the necessary equipment for all its activities.
The Fair-themed party took place last Saturday, March 28th, inside the Sports Center, and it was an excellent opportunity for new people to get to know your business and recognize the support you provide the Sports Center and the community in general.
It was a fun event, with series of small booths offering food, games and activities for the attendees, and they all seemed to have a great time and we have the photos!


text:
You have no items in your shopping cart.
Earring Display
Earring Display
New Tech Display takes a special care for our valued clients with great display of things around. You can make a better reason of finding the great scopes of action like Earring Display that is custom made! It is right here that you can order at New Tech Display for Hanging Earring Display or the special Crystal Clear Boxes for best presentation to your fiancée, wife or anyone closed to your heart. It is really going to make a special impact if the Jewelry Display is all done properly for a jeweler's shop obviously. You can make a better deal with our specially designed Earring Display for best use in fact.


text:
Warby Parker Home Try-On ProgramMonday, July 28, 2014
If you're anything like me, you live in a pair of sunglasses during the summer. I usually always have this weird tan line across the bridge of my nose from wearing glasses so much in the summer. Ah, well. There are worse problems to have. My style of sunglasses hasn't changed very much through the years. Well, except for that one time when I was 10 and wore a pair of sunglasses with red-tinted lenses everywhere. I lost them in Union Station one day, thank the good Lord! Other than that unfortunate style choice, I tend to stick to an aviator or ray ban style. They're both easy classic styles to pull off and look so summery.
After our beach trip a few weeks ago, my sunglasses were struggling. They had seen the bottom of a beach bag one too many times and kept falling off my face whenever I would slightly move my head. I had heard bits and pieces about Warby Parker and their Home Try-On program before, but now that my sunglasses had bit the dust it seemed like a good time to try it out.
Here's how it works:
You pick out the glasses you like. Warby Parker ships them straight to your door for free. You try them on, take photos, and play around with the PartyParty app (oh, just me?) until you've found the pair you like the best. Then you pack them up in their pretty little box and send them back to Warby Parker with the order slip of which ones you want. For people like me, who are skeptical of buying products online without seeing them first, this is huge! Another thing worth noting is that for every pair of glasses sold, Warby Parker will give a pair to someone in need. Pretty cool, huh?


text:
SOURCE: Adoption Council of Canada
December 16, 2013 15:35 ET
OTTAWA, ON--(Marketwired - Dec 16, 2013) - Today, the Adoption Council of Canada (ACC) is releasing three monographs, completing the series "Towards special needs parenting: Working together towards success", which began with a four- part video in August 2013. These short booklets for parents, professionals and service providers offer practical information on issues and strategies, as well as a resource list.
Each monograph examines a theme from a Canadian study of parenting adopted children (aged 1-12) with disabilities, disorders, medical conditions or prenatal substance exposure. These monographs were created from Dr. Alice Home's 26 interviews with parents, adoption associations and social workers, and from group discussions during 2012 workshops with adoption and disability communities held in Ottawa, London and Victoria. This dissemination project, which aims to make research accessible in the community, is supported by a grant from Social Sciences and Humanities Research Council awarded to Dr. Home and her team: ACC Past President Sandra Scarth and University of Windsor researcher Dr. Irene Carter.
The first and second monographs will be useful for any family dealing with child disability and for all those who help them. The third is geared specifically to the adoption community. These free monographs are available for download via the ACC website:
Monograph 1 - What's Going On? Disentangling Children's Disabilities and Getting Support
Monograph 2 - Advocacy for Children with Disabilities: Issues and Strategies
Monograph 3 - Addressing Culture and Disability in Special Needs Adoption: Challenges and Strategies
In addition to the featured monographs, the project team has released a French-version of the second video on the Stakeholder study findings. Each monograph includes a summary in French to better serve the Canadian adoption community.
"The Adoption Council of Canada is proud to add these monographs and videos to our website," says Executive Director Sarah Pedersen. "The rich content, coupled with the resource lists, are most valuable in helping us understand the complexity faced by these parents whose children have special needs. More importantly, these tools will be easily accessible anytime parents and professionals want to consult them". Pedersen adds that ACC's recent survey on special needs adoptive parenting in BC and Ontario supports the relevance of the monographs: "Our preliminary findings support the importance of the core themes and echo both the difficulty in accessing services and the ongoing need to advocate for resources".
This work is an important step in ensuring that our Canadian adoption professionals and adoptive parents are equipped with the right tools as they support our most precious gifts: our children.
This press release is also available in French. To obtain a copy, please contact Sarah Pedersen (email@example.com) or Dr. Alice Home (firstname.lastname@example.com).
For more information:
Sarah Pedersen
Executive Director
Adoption Council of CanadaEmail Contact
Dr. Alice Home
Emeritus Professor
University of OttawaEmail Contact
For more information:
Sarah Pedersen
Executive Director
Adoption Council of CanadaEmail Contact
Dr. Alice Home
Emeritus Professor
University of OttawaEmail Contact
See all RSS Newsfeeds


text:
Victron Energy
Save on Victron Energy products at Thermo Electric Direct. Hurry! Limited time offers. Offers valid only while supplies last.
Victron VE.Net Battery Controller (VBC) 12/24/48Vdc
In Stock
mpn: VBC000300000 (R),
The VE.Net Battery Controller is a device that monitors your battery status. It constantly measures the battery voltage, battery temperature, and battery current, and uses this information to calculate the actual state of charge of your battery. The ...
Victron Digital Multi Control 200/200A
In Stock
mpn: REC020005010, ean: 8719076024354,
This panel is intended both for Multi's and Quattro's. It allows PowerControl and PowerAssist current limit setting for two AC sources: a generator and shore-side current for example.The GX version has a bevel to the front face which mirrors the beve...
Viewing Page 1 of 1
Feel free to Browse Our Catalog.


text:
Tobey Maguire And Andrew Garfield Talk About Spider-Man And Success Andrew Garfield is about to enter a whole new level of celebrity that will come along with the July 3rd release of The Amazing Spider-Man. Who better to prepare him for it than the last actor who played the friendly neighborhood superhero?Tobey Maguire recently sat down with the young man who is continuing the [...] [link]
Tobey Maguire Is Producing An Alien Invasion Flick Tobey Maguire is no longer getting massive paychecks for Sony to be Spider-man, but his next producing project may be just as profitable.The actor is producing an alien invasion flick called 5th Wave, which is described as follows:"When the human race is on the verge of extinction, one of the last survivors on earth, an [...] [link]
Tobey Maguire And Leonardo Dicaprio Spared Court Battle Over Poker Cash Famous best buddies Tobey Maguire and LEONARDO DiCAPRIO and Matt Damon and Ben Affleck have been saved from a revealing court showdown over their poker winnings. [link]
Tobey Maguire sued over poker games Tobey Maguire is being sued for $300,000 for his part in a number of poker games with jailed hedge fund manager Bradley Ruderman. Tobey Maguire is bei… [link]


text:
What is all this of Virtual Reality (VR) and 360 porn videos?
2016-07-25 08:28:24
Have you ever dreamed of becoming a PornStar? Stop dreaming and begin living. The porn industry has always lead the flag of video development and it is not any different in this case. With the Virtual Reality ( VR ) Experience you will feel that you are in the middle of the scene. It all began with the consumers, porn users were consuming traditional, flat, boring and not innovative videos so they asked for more, and technology gave them more.
This whole new way of consuming Porn videos is revolutionary and is definitely here to stay. With video in 360 degree in 4K resolution and surround audio you will feel every sultry moan from the direction it is made, is like living the movie, becoming a master of sex, you could actually learn techniques from the masters ;) Subscribe to www.Virtual360sexxx.com and have a boner like never before while watching porn ;)
To enjoy this experience you will only need ONE of the next devices:
- Smartphone ANDROID or IOS: You can watch ALL of our videos with only your Smartphone, You could aim in 360 degrees around you or simply sit, relax and swipe with your finger
- Cardboards: It is the cheapest device for consuming Virtual Reality (VR) Porn, just buy it on the internet (Suggest Google Cardboard) put your device on and plunge into a whole new world of sex.
- Oculus Rift: Inmmerse in a full HD screen video where your eyeballs will see something everywhere you are looking for! These VR porn videos are going to delight all your senses with the technology of the device.
- Samsung Gear VR: The Samsung bet for VR videos is a really nice piece. It is very easy to use with your samsung smartphone and let you use it for many hours before getting tired. If you want to sit on the coach and enjoy as many VR porn videos you want, this is for you.
- HTC Vive: In Difference with other devices, the HTC Vive allows you to watch 1100 of porn at the same time, yes, 1100 of pussy, ass, tits and really high quality porn. If you are a toy / gadget lover, this is for you. Best one in the market and many uses.
But stop wandering how it looks like. Click here and tell your friends. Here is a sneak peak.


text:
Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis
- 11k Downloads
- Citations
Intraarticular hyaluronan (HA) is used clinically for symptomatic relief in patients with knee osteoarthritis (OA); however, the mechanism of action is unclear. In this study, we examined the effects of a single injection of HA on joint tissue pathology, mechanical allodynia and gait changes (measured by stride times) in a murine model of OA.
OA was induced in the right knee joint (stifle) of 12-week-old male C57BL/6 mice by transforming growth factor β1 (TGFβ1) injection and treadmill running for 14 days. Gait parameters were quantified by using TreadScan, mechanical allodynia was evaluated with von Frey filaments, and joint pathology was evaluated by scoring of macroscopic images for both cartilage erosion and periarticular fibrosis. HA or saline control was injected 1 day after TGFβ1 injection but before the start of treadmill running.
OA development in this model was accompanied by significant (P < 0.01) enhancement of the stance and propulsion times of affected legs. HA injection (but not saline injection) blocked all gait changes and also protected joints from femoral cartilage erosion as well as tibial and femoral tissue fibrosis. Both HA injection and saline injection attenuated acute allodynia, but the HA effect was more pronounced and prolonged than the saline injection.
We conclude that videographic gait analysis is an objective, sensitive and reproducible means of monitoring joint pathology in experimental murine OA, since stance time appears to correlate directly with OA severity. A single injection of HA prevents acute and prolonged gait changes and ameliorates the cartilage erosion and periarticular fibrosis normally seen in this model. We speculate that the capacity of HA to prevent cartilage erosion results from its normalization of joint biomechanics and its inhibitory effects on periarticular cells, which are involved in tissue hyperplasia and fibrosis. This effect of exogenous HA appears to mimic the protective effects of ablation of Adamts5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) on experimental murine OA, and we speculate that a common mechanism is involved.
KeywordsGait Analysis Mechanical Allodynia Gait Parameter Stride Time Medial Tibial Plateau
bovine serum albumin
cell surface hyaluronan receptor
receptor for hyaluronan-mediated motility
- TGFβ1
transforming growth factor β1.
Progressive osteoarthritis (OA) of the knee is characterized by synovial inflammation, cartilage erosion, soft tissue fibrosis and subchondral bone sclerosis as well as pain and stiffness in the affected joints [1]. One widely used therapy for symptomatic relief of pain and stiffness is the intraarticular injection of hyaluronan (HA). A meta-analysis of clinical trials in which an aggregate total of 18 different commercial HA preparations were used summarized the results as "generally supporting the use of HA in the treatment of OA" [2] (page 3). Overall, the aforementioned analyses support the use of the HA class of products in the treatment of knee OA.
In a second meta-analysis [3], the conclusion was that HA injection led to a modest improvement in symptoms, including pain, relative to placebo. The variability in outcomes between these studies might be related to the different evaluation scales used (for example, the Western Ontario and McMaster Universities Osteoarthritis Index [4] and the Knee Injury and Osteoarthritis Outcome Score [5]) or to the finding that pain improvement with HA appears to be confined to individuals older than about 60 years of age [6].
In addition to potential symptomatic relief, there is ample evidence for statistically significant disease-modifying effects of intraarticular HA injection in both animal models and human OA [7]. For example, in rat and rabbit OA models, HA has been found to block inflammation and chondrocyte apoptosis and to prevent cartilage degeneration [8, 9, 10]. In the canine anterior cruciate ligament transection model [11], HA inhibited the formation of a fibroblast-like cell layer on the articular surface, reduced cartilage lesions and significantly improved both gross joint morphology and histopathology. In both canine and ovine OA models, subintimal fibrosis and hypervascularity of the synovium was reduced after intraarticular HA injection [12, 13]. The clinical relevance of such observations is underscored by reports of human OA in which HA has been found to reconstitute the superficial cartilage layer [14], reduce synovial inflammation and edema [15] and reduce the number and aggregation of lining synoviocytes [16], as well as to reduce the progression of joint space narrowing in patients with high joint space width upon entry into the study [17]. Although the cell biological mechanisms underlying the action of HA in both animal models and human OA are poorly understood, the capacity of HA to inhibit aberrant tissue remodeling in the joint appears to be related to its efficacy in postsurgical repair in other tissues and organs. For example, ocular, thoracic and plastic surgery all involve the use of HA to optimize tissue restoration and minimize scarring [18, 19], and HA is also used to prevent postoperative peritoneal and intrauterine adhesions [20, 21].
The overall objective in the current work was to examine the effect of intraarticular HA injection on well-defined stages of the initiation and progression of murine OA. We have utilized a nonsurgical murine model of OA [22] which has a highly reproducible disease course leading to overt pathology in 3 weeks. In addition to performing macroscopic and microscopic evaluations of joint tissue structure, we determined mechanical allodynia (pain caused by stimuli that do not normally evoke pain [23]) and locomotive function of the hindlimbs by using the TreadScan™ gait analysis system (CleverSys Inc., Reston, VA, USA). We describe statistically robust changes in gait parameters during the different phases of OA development and show ameliorative effects of HA injection. In brief, our data show that a single injection of HA during the early transforming growth factor β1 (TGFβ1)-induced inflammatory phase of the model prevents both acute and long-term gait changes. In addition, the normalization of gait by HA injection is accompanied by a marked reduction in both cartilage erosion and intraarticular soft tissue fibrosis.
Materials and methods
Hyaluronan preparation
HA (Durolane; Smith & Nephew Inc., London, UK) was prepared from purified staphylococcal HA at Q-Med AB, Uppsala, Sweden. Briefly, HA is dispersed in solution and cross-linked via hydroxyl groups with butanediol diglycidyl ether. About one cross-link is formed per 100 disaccharides, and the final HA concentration is 20 μg/ml. Ten microliters of HA (75% vol/vol in saline, pH 6.8) were injected through the patellar ligament into the joint space using an insulin syringe fitted with a 30-gauge needle. The accuracy of the injection procedure for HA was verified with untreated mice (n = 6) using an HA/India ink solution (10:1 vol/vol) for injection, and accurate delivery was verified by the presence of the dye exclusively in the synovial cavity on dissection.
Osteoarthritis model
Male mice (C57BL/6, age 12 weeks) were bred in-house, and all animal protocols were approved by the Rush University Medical Center Animal Care Committee. OA was induced as described previously [22]. Briefly, the procedure involves unilateral intraarticular injection of active TGFβ1 (200 ng in 0.1% (wt/vol) bovine serum albumin) at 0 and 48 hours, followed by daily enforced uphill treadmill running (17° gradient at 32 cm/second for 20 minutes) for 2 weeks.
Experimental groups and number of mice examined
Gait measurement using TreadScan
Gait analysis was done using TreadScan at the time points indicated in Figure 1. The treadmill and TreadScan equipment were housed in a designated light- and temperature-controlled room. Gait measurements were always taken before treadmill running on any particular day and were carried out by the same individual throughout the study. TreadScan data on each mouse were acquired for about 20 seconds of fast walking at 18 cm/second at a 17° uphill gradient. This configuration represented optimal conditions for achieving continuous walking and more regular stride times for the C57BL/6 mouse strain used in this study. The recorded walking activity was analyzed using TreadScan version 3.0 software, which calculates the mean value for 37 locomotion parameters for each mouse from about 1,500 high-quality video frames. For the present study, data analysis was restricted to the components of the stride cycle for the hindfeet. The stride cycle represents the sum of the stance and swing times. The stance time for a hindfoot is the elapsed period between the first contact ("heel strike") and the last contact ("liftoff") with the surface and is the sum of brake and propulsion times. The brake time is the elapsed period between heel strike and the instant at which the foot reaches a position which is 80% of the distance from the front to the rear of the mouse (excluding the tail). This position represents the normal still stance position for mice. The propulsion time is the stance time minus the brake time. Presently, TreadScan does not directly evaluate loading through force plates as is done routinely in large animal studies [24] and human gait studies [25].
Mechanical allodynia
Mechanical allodynia was determined by using von Frey filaments as described previously [23], with each 50% withdrawal threshold value (measured in grams) calculated as the average of three sequential measurements made at 5-minute intervals. Measurements were taken by the same individual for all mice and were done before treadmill running on any particular day as indicated in the schematic in Figure 1. A separate set of mice (n = 8) for each treatment group was used for measurement of mechanical allodynia only.
Joint pathology
Macroscopic cartilage erosion and fibrosis scoring was done essentially as described previously [22] with the inclusion of patellar groove analysis. On day 19, right (injected) knee joints were carefully opened and menisci were removed, and after rinsing them with phosphate-buffered saline, India ink was applied to all articular surfaces with a small paint brush, and then they were rinsed again. Surfaces were photographed under a Nikon dissecting microscope (SMZ1000) (Melville, NY, USA) at sixfold magnification and images were processed using SPOT Basic imaging software (Diagnostic Instruments, Inc., Sterling Heights, MI, USA) at 32-fold magnification. For each joint, cartilage erosion scoring was carried out with the investigator blinded to sample identity. The twelve areas scored were the proximal and distal regions of the lateral and medial patellar grooves, the anterior and posterior regions of the lateral and medial femoral condyles and the anterior and posterior regions of the lateral and medial tibial plateaus. Scores (1 through 8) for each of the twelve areas were based on a visual estimate of the percentage of the specific cartilage surface affected by lesions, where a score of 8 was equivalent to 100%. Individual joint data were calculated for the patellar groove (32 maximum), the femoral condyle (32 maximum) and the tibial plateau (32 maximum) areas separately. In OA joints, macroscopic fibrosis developed at one or more of six locations. These were the posterior half of the medial and lateral tibial plateaus, the anterior half of the medial and lateral femoral condyles and the distal half of the medial and lateral patellar groove. In each location, fibrosis appeared as a variably sized whitish rim to the articular surface. Scores (0 through 3) were done with the investigator blinded to sample identity and were based on a visual estimate of the area of the lesion relative to the area (set arbitrarily at 10) of the respective articular surface. A score of 3 (maximum observed) corresponded to a lesion with an area equivalent to about 30% of the total area being scored. Individual joint fibrosis data were calculated separately for the medial and lateral anterior femoral condyles (6 maximum), the distal medial and distal lateral patellar groove (6 maximum) and the posterior lateral and medial tibial plateaux (6 maximum).
Histology and immunohistochemistry
Following macroscopic evaluation, femoral joints were placed intact in 10% neutral buffered formalin for 48 hours, decalcified in 0.5 M ethylenediaminetetraacetic acid for 14 days, processed and embedded in paraffin. Whole joint sagittal sections (5 μm) were obtained from approximately 10 equidistant locations spanning the entire lateral and medial compartments. Sections were deparaffinized and stained with Safranin O/Fast Green. For immunohistochemistry, sections were treated with proteinase K (5 mg/ml at 37°C for 30 minutes; Sigma-Aldrich St. Louis, MO, USA) for epitope retrieval prior to primary antibody incubation. The type I collagen-specific antibody (ab34710; Abcam, Cambridge, MA, USA) was used at 10 μg/ml with incubation for 1 hour. The secondary antibody was peroxidase-coupled goat antirabbit immunoglobulin G (IgG). Preimmune rabbit IgG was used as a first antibody control.
Data normalization and statistical analysis
Gait analyses in pilot studies using this OA model showed that a statistical power >80% can be achieved with 10 mice per group. In the study reported here, the value (expressed in milliseconds) for each gait parameter (on days 5, 12 and 19) in each hindlimb of each mouse was normalized to the corresponding pretreatment value for that mouse. This was done to minimize animal variation, which, on a weight basis, ranged from approximately 23 g to 26 g. The significance of the difference between the mean (±SD) of the normalized values and unity was determined by using an unpaired Student's t-test and a signed two-tailed Wilcoxon rank-sum test. The allodynia data (in grams) are the means of the 50% withdrawal threshold values for each group at each time point, and the significance of the difference between treatment groups was determined by using Student's t-test only. For both statistical tests, P values < 0.05 were considered statistically significant.
Induction of murine OA causes an acute and prolonged increase in stance and propulsion times, and intraarticular HA injection prevents these gait changes
Effect of hyaluronan injection on the mean normalized stance and propulsion times of affected limbs in murine osteoarthritis modela
Day 5
Day 12
Day 19
Mean (±SD) b
Student's t-test
Mean (±SD) b
Student's t-test
Mean (±SD) b
Student's t-test
OA (n = 14)
1.18 (0.24)
1.40 (0.47)
1.43 (0.40)
OA + HA (n = 14)
1.05 (0.19)
1.10 (0.21)
0.99 (0.17)
OA + saline (n = 8)
1.29 (0.14)c
1.24 (0.26)
1.32 (0.30)
OA (n = 14)
1.46 (0.43)
1.28 (0.43)
1.61 (0.56)
OA + HA (n = 14)
1.19 (0.31)
1.26 (0.36)
0.94 (0.36)
OA + saline (n = 8)
1.78 (0.14)c
1.16 (0.43)
1.55 (0.18)
Effect of hyaluronan injection on the mean of normalized stance and propulsion times of contralateral limb in murine osteoarthritis model
Day 5
Day 12
Day 19
Mean (±SD) b
Student's t-test
Mean (±SD) b
Student's t-test
Mean (±SD) b
Student's t-test
OA (n = 14)
1.10 (0.34)
1.16 (0.29)
1.03 (0.13)
OA + HA (n = 14)
0.95 (0.15)
1.10 (0.20)
1.10 (0.20)
OA + saline (n = 8)
0.97 (0.06)c
1.23 (0.26)
1.21 (0.26)
OA (n = 14)
0.92 (0.41)
1.11 (0.42)
1.16 (0.46)
OA + HA (n = 14)
0.80 (0.21)
1.01 (0.19)
0.97 (0.20)
OA + saline (n = 8)
0.78 (0.25)c
1.05 (0.14)
1.17 (0.52)
Intraarticular HA or saline reduces allodynia in OA limbs, but only HA is effective for prolonged periods
Measurements for allodynia in both limbs of mice from the three treated groups (OA, OA + HA and OA + saline) at days 5, 12 and 19 are shown in Figure 3b. For the OA group at day 5, the mean allodynia score in the injected limbs was approximately 0.35 g, which represents a major increase in allodynia, and this score was maintained up to day 19. The OA + HA group exhibited a significant reduction (P < 0.0001) in allodynia (increase in gram value) relative to the OA group at days 5, 12 and 19. The OA + saline group also exhibited a significant reduction (P < 0.0001) at all times, showing that for this measurement, at least part of the effect of HA appears to be due simply to the dilution of the joint fluids. However, when the same data were analyzed in terms of differences from baseline scores, the OA + HA group showed normalization (that is, the difference between mean score and mean baseline score was not significant) at days 5 and 19 and a trend to normalization on day 12. However the OA + saline group did not exhibit such normalization at any time. The greater protective effect of HA relative to saline on allodynia in the OA limb was most evident at day 19. At this time, allodynia in the OA + HA group was markedly reduced relative to the OA group (P < 0.0001). Allodynia for the OA + saline group was also reduced relative to the OA group, but the reduction was minor relative to the HA effect, and a return to baseline levels did not occur at any time.
Finally, the contralateral limbs of animals in the OA group and the OA + saline group showed significantly increased allodynia relative to baseline (P < 0.006 and P < 0.05, respectively) at day 5 (Figure 3b). This increase did not occur, however, in the OA + HA group, showing that at this early time, only HA had a protective effect against allodynia in both OA and contralateral limbs. In addition, the increased allodynia in the contralateral limbs was not accompanied by any change in gait parameters.
Intraarticular HA, but not saline, protects against cartilage erosion and fibrosis in murine OA
The data presented here (Figures 4, 5, 7 and 8) support the results of previous studies on experimental OA in rabbits and dogs showing that intraarticular HA can suppress synovial hyperplasia [10] and fibroblastic encroachment onto the articular surface [11] while protecting against cartilage erosion [26, 27]. These therapeutic effects appear to be independent of the polymeric structure of HA, since the work described here was done with a cross-linked bacterial HA, whereas in other studies [8, 9, 10] non-cross-linked, high-molecular-weight preparations were found to be effective. The results of the histopathology in the current study suggest that HA blocks the ingress of activated periosteal and synovial cells and also protects against the loss of cells and matrix from femoral and patellar groove cartilages. While the precise mode of action of HA on these cells is unknown, our studies in the TTR and DMM models of OA have shown that ablation of Adamts5, prevents both cartilage erosion and fibrotic remodeling in challenged joints [20], just like HA injection in the TTR model. Since ADAMTS5 protein has been isolated in a complex with HA from both human OA cartilage [28] and degenerative equine ligaments [29], it is possible that injected HA may act primarily by blocking ADAMTS5-mediated activation of profibrotic pathways in periarticular cells.
In this regard, the current findings should provide a new framework for mechanistic studies on the effects of HA injection on OA pathology. This will be facilitated by the availability of a range of genetically modified mice in which HA-responsive components of well-established cellular pathways have been modified. For example, studies with knockout mice lacking HA-binding receptors, such as CD44 and RHAMM (receptor for hyaluronan-mediated motility) or Toll-like receptors 2 and 4, might illuminate the mechanism by which injected HA is retained in or near the joint space. Thus binding of exogenously delivered HA to such receptors might abrogate cell stress responses to joint injury, processes which might otherwise result in inflammation, cytokine release and accelerated tissue destruction [30, 31, 32].
Meta-analyses of clinical trials [3] have concluded that HA injection in humans has a real but modest effect over placebo on subjective patient pain measures. In the present work, we have used von Frey filaments to examine the potential pain-relieving effects of HA (or saline) injected during the early inflammatory phase. The most notable finding was that HA was superior to saline with regard to pain relief, but there was a marked difference only on day 19 of the model, when joint lesions were most advanced. This suggests that pain relief by HA injection includes both short-lived and longer-lived mechanisms. The short-lived effects appear to operate largely by dilution of the joint fluid, whereas the long-lived effects are probably specific to HA and may require its direct or indirect blockade of pain receptors [33]. The finding that HA, but not saline, injection eliminated the transient allodynia in the contralateral limb suggests that it may sequester factors which would otherwise enter the circulation. In this regard, Gomis et al. [33] suggested that HA reduces joint nociceptor activity in part because of its rheological properties but also by binding inflammatory mediators present in the joint tissues.
Probably the major contribution of the present work is the development and validation of gait analysis as an important tool in the evaluation of murine models of OA. In essence, we have shown that experimental murine OA is accompanied by no change in stride time but a consistent increase in percentage stance time (an increase from approximately 48% to about 75% in the present model) when measured at 18 cm/second on a 17° uphill gradient. Importantly, the magnitude of the percentage stance changes associated with this OA model is sufficient to readily examine the effects of therapeutic interventions. Further, the same OA mice exhibited a prolonged enhancement in mechanical allodynia in the affected limb, a readout which can also be readily monitored.
Notably, an association of OA joint damage and increased percentage stance time (at a standard velocity) was also recently reported in a study using 9-month-old type IX collagen-deficient (Col9-/-) mice [34]. The authors suggested as a possible mechanism for the increased stance time in this spontaneous OA model that the knockout mice adapted with an altered locomotion pattern (increased percentage stance time) to potentially reduce peak joint forces and thus protect the hindlimbs during walking. This idea is supported by the finding that a reduction in peak force across the normal mouse knee occurs as the total stance time increases [35].
The process that results in the increased percentage stance time in the present murine OA model remains to be investigated. An important clue may be provided by the observation that the maximum increase in percentage stance time (about 27% on day 19) was already increased by about 10% on day 5, which is before the start of treadmill running (see Figure 2 and Table 1). This indicates that the gait change can be initiated by TGFβ1 injection alone; however, it is not further increased or maintained in the absence of treadmill challenge (data not shown). It therefore may result from a loss of knee laxity due to the accompanying fibrosis of the soft tissues. Alternatively, inflammation and functional impairment in the biceps femorus, which lifts the lower hindleg during swing phase and stabilizes it during stance [36] might be a contributing factor.
Further mechanistic insight is provided by the finding in a previous study [37] that in collagen-induced inflammatory ankle arthritis, severe disease is accompanied by a decrease in stride time (due to decreases in both stance and swing times), a decrease in stride length and an increase in stride frequency (speed set at 15 cm/second). In another study [38], it was found that induction of OA by interleukin 1β injection into rat knees resulted in an asymmetric gait (measured at constant speed) in which the percentage stance time in the affected limb was reduced relative to the contralateral limb. The general finding that gait adaptations measured at constant speed are very different in ankle inflammation [37], knee inflammation [38] and knee injury (present study) illustrates the discriminatory power of gait analysis for different forms, stages and severities of murine arthritis. In this regard, the establishment of standardized procedures [39] for the evaluation of gait parameters in murine OA models should be added to existing methods, such as whole joint macroscopic pathology ([22] and present study), confocal laser-scanning microscopy [40] and histopathology [41].
Finally, it appears that the current murine study has clear clinical relevance, since human OA is also accompanied by increases in percentage stance time [42, 43]. In this case, the increase results directly from the fact that during voluntary locomotion, OA patients walk more slowly than normal controls [44]. This does not, of course, exclude the possibility that OA patients have a higher percentage stance time than normal individuals at the same walking speed. In either case, it is clear that OA patients adapt to achieve walking conditions which increase percentage stance time and thereby stabilize the affected limb; however, in patients with symptomatic OA, this strategy is accompanied by higher than normal peak loading and higher than normal loading throughout stance time [45]. In this regard, the current murine model appears to accurately mimic the gait adaptations seen in human OA, although it is unknown whether the increased percentage stance time in murine OA is accompanied by higher or lower peak loading and loading throughout stance time. Whether HA therapy in human OA is accompanied by a change in walking speed and/or a reduction in percentage stance time also remains to be determined.
In the present study, we have shown that a single injection of HA ameliorates both gait changes and the location-specific tissue destruction seen in the unilateral TTR murine model of OA. These findings are consistent with the conclusion that the gait change itself (that is, a major increase in percentage stance time), while apparently a protective response, may in fact be responsible for exacerbating the biomechanical and cellular biological processes which are responsible for disease progression.
We also conclude that gait analysis represents a valuable addition to the methods currently used for evaluation of the severity of joint changes in murine arthritis models. Gait analysis is particularly useful because it can provide multiple, objective, quantitative readouts on all limbs of individual mice throughout the time course of an experiment. When used in conjunction with genetically modified mice, gait analysis has a unique potential to provide mechanistic information on the relationship between locomotion and the tissue damage pathways of OA initiation and progression.
Author's information
AP holds the Robert S Katz, MD-Joan and Paul Rubschlager Presidential Professorship in Osteoarthritis Research at Rush University, Chicago, IL, USA.
We acknowledge the support of Smith & Nephew Inc. with regard to study design and statistical powering. We are grateful for the assistance of Sue Luergans, PhD, for statistical analysis. We also thank Anne-Marie Malfait for discussions of allodynia data, as well as Laura Thorp, PhD, Najia Shakoor, MD, Vincent Wang, PhD, and Markus Wimmer, PhD, for insightful discussion of human biomechanics and gait analysis. AP received funding from the Katz Rubschlager Endowment for Osteoarthritis Research.
Supplementary material
- 1.Keen HI, Mease PJ, Bingham CO, Giles JT, Kaeley G, Conaghan PG: Systematic review of MRI, ultrasound, and scintigraphy as outcome measures for structural pathology in interventional therapeutic studies of knee arthritis: focus on responsiveness. J Rheumatol. 2011, 38: 142-154. 10.3899/jrheum.100377.CrossRefPubMedGoogle Scholar
- 2.Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G: Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev. 2006, 2: CD005321-PubMedGoogle Scholar
- 3.Divine JG, Zazulak BT, Hewett TE: Viscosupplementation for knee osteoarthritis: a systematic review. Clin Orthop Relat Res. 2007, 455: 113-122. 10.1097/BLO.0b013e31802f5421.CrossRefPubMedGoogle Scholar
- 4.Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW: Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or the knee. J Rheumatol. 1988, 15: 1833-1840.PubMedGoogle Scholar
- 5.Roos EM, Roos HP, Lohmander LS, Ekdahl C, Beynnon BD: Knee Injury and Osteoarthritis Outcome Score (KOOS): development of a self-administered outcome measure. J Orthop Sports Phys Ther. 1998, 28: 88-96.CrossRefPubMedGoogle Scholar
- 6.Lohmander LS, Dalén N, Englund G, Hämäläinen M, Jensen EM, Karlsson K, Odensten M, Ryd L, Sernbo I, Suomalainen O, Tegnander A: Intra-articular hyaluronan injections in the treatment of osteoarthritis of the knee: a randomised, double blind, placebo controlled multicentre trial. Hyaluronan Multicentre Trial Group. Ann Rheum Dis. 1996, 55: 424-431. 10.1136/ard.55.7.424.PubMedCentralCrossRefPubMedGoogle Scholar
- 7.Goldberg VM, Buckwalter JA: Hyaluronans in the treatment of osteoarthritis of the knee: evidence for disease-modifying activity. Osteoarthritis Cartilage. 2005, 13: 216-224. 10.1016/j.joca.2004.11.010.CrossRefPubMedGoogle Scholar
- 8.Ando A, Hagiwara Y, Chimoto E, Hatori K, Onoda Y, Itoi E: Intra-articular injection of hyaluronan diminishes loss of chondrocytes in a rat immobilized-knee model. Tohoku J Exp Med. 2008, 215: 321-331. 10.1620/tjem.215.321.CrossRefPubMedGoogle Scholar
- 9.Zhou PH, Liu SQ, Peng H: The effect of hyaluronic acid on IL-1β-induced chondrocyte apoptosis in a rat model of osteoarthritis. J Orthop Res. 2008, 26: 1643-1648. 10.1002/jor.20683.CrossRefPubMedGoogle Scholar
- 10.Yoshioka M, Shimizu C, Harwood FL, Coutts RD, Amiel D: The effects of hyaluronan during the development of osteoarthritis. Osteoarthritis Cartilage. 1997, 5: 251-260. 10.1016/S1063-4584(97)80021-0.CrossRefPubMedGoogle Scholar
- 11.Smith G, Myers SL, Brandt KD, Mickler EA, Albrecht ME: Effect of intraarticular hyaluronan injection on vertical ground reaction force and progression of osteoarthritis after anterior cruciate ligament transection. J Rheumatol. 2005, 32: 325-334.PubMedGoogle Scholar
- 12.Cake MA, Smith MM, Young AA, Smith SM, Ghosh P, Read RA: Synovial pathology in an ovine model of osteoarthritis: effect of intraarticular hyaluronan (Hyalgan). Clin Exp Rheumatol. 2008, 26: 561-567.PubMedGoogle Scholar
- 13.Asari A, Miyauchi S, Matsuzaka S, Ito T, Kominami E, Uchiyama Y: Molecular weight-dependent effects of hyaluronate on the arthritic synovium. Arch Histol Cytol. 1998, 61: 125-135. 10.1679/aohc.61.125.CrossRefPubMedGoogle Scholar
- 14.Guidolin DD, Ronchetti IP, Lini E, Guerra D, Frizziero L: Morphological analysis of articular cartilage biopsies from a randomized, clinical study comparing the effects of 500-730 kDa sodium hyaluronate (Hyalgan) and methylprednisolone acetate on primary osteoarthritis of the knee. Osteoarthritis Cartilage. 2001, 9: 371-381. 10.1053/joca.2000.0398.CrossRefPubMedGoogle Scholar
- 15.Frizziero L, Govoni E, Bacchini P: Intra-articular hyaluronic acid in the treatment of osteoarthritis of the knee: clinical and morphological study. Clin Exp Rheumatol. 1998, 16: 441-449.PubMedGoogle Scholar
- 16.Pasquali Ronchetti I, Guerra D, Taparelli F, Boraldi F, Bergamini G, Mori G, Zizzi F, Frizziero L: Morphological analysis of knee synovial membrane biopsies from a randomized controlled clinical study comparing the effects of sodium hyaluronate (Hyalgan) and methylprednisolone acetate (Depomedrol) in osteoarthritis. Rheumatology (Oxford). 2001, 40: 158-169. 10.1093/rheumatology/40.2.158.CrossRefGoogle Scholar
- 17.Jubb RW, Piva S, Beinat L, Dacre J, Gishen P: A one-year, randomised, placebo (saline) controlled clinical trial of 500-730 kDa sodium hyaluronate (Hyalgan) on the radiological change in osteoarthritis of the knee. Int J Clin Pract. 2003, 57: 467-474.PubMedGoogle Scholar
- 18.Thirumalai B, Blamires TL, Brooker L, Deeks J: Heavier molecular weight ocular viscoelastic devices and timing of post-operative review following cataract surgery. BMC Ophthalmol. 2007, 7: 2-10.1186/1471-2415-7-2.PubMedCentralCrossRefPubMedGoogle Scholar
- 19.Chhetri DK, Mendelsohn AH: Hyaluronic acid for the treatment of vocal fold scars. Curr Opin Otolaryngol Head Neck Surg. 2010, 18: 498-502. 10.1097/MOO.0b013e32833f85d1.CrossRefPubMedGoogle Scholar
- 20.Schnüriger B, Barmparas G, Branco BC, Lustenberger T, Inaba K, Demetriades D: Prevention of postoperative peritoneal adhesions: a review of the literature. Am J Surg. 2011, 201: 111-121.CrossRefPubMedGoogle Scholar
- 21.Deans R, Abbott J: Review of intrauterine adhesions. J Minim Invasive Gynecol. 2010, 17: 555-569. 10.1016/j.jmig.2010.04.016.CrossRefPubMedGoogle Scholar
- 22.Li J, Anemaet W, Diaz MA, Buchanan S, Tortorella M, Malfait AM, Mikecz K, Sandy JD, Plaas A: Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models. J Orthop Res. 2011, 29: 516-522. 10.1002/jor.21215.CrossRefPubMedGoogle Scholar
- 23.Malfait AM, Ritchie J, Gil AS, Austin JS, Hartke J, Qin W, Tortorella MD, Mogil JS: ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization. Osteoarthritis Cartilage. 2010, 18: 572-580. 10.1016/j.joca.2009.11.013.CrossRefPubMedGoogle Scholar
- 24.Oosterlinck M, Pille F, Huppes T, Gasthuys F, Back W: Comparison of pressure plate and force plate gait kinetics in sound Warmbloods at walk and trot. Vet J. 2010, 186: 347-351. 10.1016/j.tvjl.2009.08.024.CrossRefPubMedGoogle Scholar
- 25.Andriacchi TP, Dyrby CO: Interactions between kinematics and loading during walking for the normal and ACL deficient knee. J Biomech. 2005, 38: 293-298. 10.1016/j.jbiomech.2004.02.010.CrossRefPubMedGoogle Scholar
- 26.Amiel D, Toyoguchi T, Kobayashi K, Bowden K, Amiel ME, Healey RM: Long-term effect of sodium hyaluronate (Hyalgan) on osteoarthritis progression in a rabbit model. Osteoarthritis Cartilage. 2003, 11: 636-643. 10.1016/S1063-4584(03)00119-5.CrossRefPubMedGoogle Scholar
- 27.Wenz W, Breusch SJ, Graf J, Stratmann U: Ultrastructural findings after intraarticular application of hyaluronan in a canine model of arthropathy. J Orthop Res. 2000, 18: 604-612. 10.1002/jor.1100180413.CrossRefPubMedGoogle Scholar
- 28.Plaas A, Osborn B, Yoshihara Y, Bai Y, Bloom T, Nelson F, Mikecz K, Sandy JD: Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages. Osteoarthritis Cartilage. 2007, 15: 719-734. 10.1016/j.joca.2006.12.008.CrossRefPubMedGoogle Scholar
- 29.Plaas A, Sandy JD, Liu H, Diaz MA, Schenkman D, Magnus RP, Bolam-Bretl C, Kopesky PW, Wang VM, Galante JO: Biochemical identification and immunolocalizaton of aggrecan, ADAMTS5 and inter-α-trypsin-inhibitor in equine degenerative suspensory ligament desmitis. J Orthop Res. 2011AGoogle Scholar
- 30.Huebener P, Abou-Khamis T, Zymek P, Bujak M, Ying X, Chatila K, Haudek S, Thakker G, Frangogiannis NG: CD44 is critically involved in infarct healing by regulating the inflammatory and fibrotic response. J Immunol. 2008, 180: 2625-2633.CrossRefPubMedGoogle Scholar
- 31.Tolg C, Hamilton SR, Nakrieko KA, Kooshesh F, Walton P, McCarthy JB, Bissell MJ, Turley EA: Rhamm-/- fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair. J Cell Biol. 2006, 175: 1017-1028. 10.1083/jcb.200511027.PubMedCentralCrossRefPubMedGoogle Scholar
- 32.Paun A, Fox J, Balloy V, Chignard M, Qureshi ST, Haston CK: Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice. Int J Radiat Oncol Biol Phys. 2010, 77: 1198-1205. 10.1016/j.ijrobp.2009.12.065.CrossRefPubMedGoogle Scholar
- 33.Gomis A, Miralles A, Schmidt RF, Belmonte C: Intra-articular injections of hyaluronan solutions of different elastoviscosity reduce nociceptive nerve activity in a model of osteoarthritic knee joint of the guinea pig. Osteoarthritis Cartilage. 2009, 17: 798-804. 10.1016/j.joca.2008.11.013.CrossRefPubMedGoogle Scholar
- 34.Allen KD, Griffin TM, Rodriguiz RM, Wetsel WC, Kraus VB, Huebner JL, Boyd LM, Setton LA: Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen. Arthritis Rheum. 2009, 60: 2684-2693. 10.1002/art.24783.PubMedCentralCrossRefPubMedGoogle Scholar
- 35.Clarke KA, Smart L, Still J: Ground reaction force and spatiotemporal measurements of the gait of the mouse. Behav Res Methods Instrum Comput. 2001, 33: 422-426. 10.3758/BF03195396.CrossRefPubMedGoogle Scholar
- 36.Schumann NP, Biedermann FH, Arnold D, Jinnah HA, Grassme R, Fischer MS, Scholle HC: Treadmill locomotion in normal mice: step related multi-channel EMG profiles of thigh muscles. Pathophysiology. 2006, 13: 245-255. 10.1016/j.pathophys.2006.09.002.CrossRefPubMedGoogle Scholar
- 37.Vincelette J, Xu Y, Zhang LN, Schaefer CJ, Vergona R, Sullivan ME, Hampton TG, Wang YX: Gait analysis in a murine model of collagen-induced arthritis. Arthritis Res Ther. 2007, 9: R123-10.1186/ar2331.PubMedCentralCrossRefPubMedGoogle Scholar
- 38.Allen KD, Adams SB, Mata BA, Shamji MF, Gouze E, Jing L, Nettles DL, Latt LD, Setton LA: Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist. J Orthop Res. 2010Google Scholar
- 39.Wooley CM, Xing S, Burgess RW, Cox GA, Seburn KL: Age, experience and genetic background influence treadmill walking in mice. Physiol Behav. 2009, 96: 350-361. 10.1016/j.physbeh.2008.10.020.PubMedCentralCrossRefPubMedGoogle Scholar
- 40.Moodie JP, Stok KS, Müller R, Vincent TL, Shefelbine SJ: Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity. Osteoarthritis Cartilage. 2011, 19: 163-170. 10.1016/j.joca.2010.11.006.CrossRefPubMedGoogle Scholar
- 41.Glasson SS, Chambers MG, Van Den Berg WB, Little CB: The OARSI histopathology initiative: recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage. 2010, 18 (Suppl 3): S17-S23. 10.1016/j.joca.2010.05.025.CrossRefPubMedGoogle Scholar
- 42.Al-Zahrani KS, Bakheit AM: A study of the gait characteristics of patients with chronic osteoarthritis of the knee. Disabil Rehabil. 2002, 24: 275-280. 10.1080/09638280110087098.CrossRefPubMedGoogle Scholar
- 43.Gök H, Ergin S, Yavuzer G: Kinetic and kinematic characteristics of gait in patients with medial knee arthrosis. Acta Orthop Scand. 2002, 73: 647-652.CrossRefPubMedGoogle Scholar
- 44.Kiliçoğlu O, Dönmez A, Karagülle Z, Erdoğan N, Akalan E, Temelli Y: Effect of balneotherapy on temporospatial gait characteristics of patients with osteoarthritis of the knee. Rheumatol Int. 2010, 30: 739-747.CrossRefPubMedGoogle Scholar
- 45.Thorp LE, Sumner DR, Block JA, Moisio KC, Shott S, Wimmer MA: Knee joint loading differs in individuals with mild compared with moderate medial knee osteoarthritis. Arthritis Rheum. 2006, 54: 3842-3849. 10.1002/art.22247.CrossRefPubMedGoogle Scholar
Copyright information
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


text:
There are two power triangles at play here. The first: people – process – technology,
defines the dependencies that underpin the project. The second: scope – time – cost,
is a relationship triangle that cannot be broken. If you are running out of time, you can
either reduce the scope or spend more money. Running out of money means you
reduce the scope and this impacts the timeframe. Increasing the scope in any way will
ALWAYS result in overspend and delay. The secret is to limit the initial scope to
something manageable, control the delivery to meet this initial scope and then launch
additional projects to drive the product deeper and more broadly into the organization.


text:
$3000 price reduction, owner wants it gone.The 260 Sea Ray Sundancer is a mid-cabin design with comfortable accommodations and a well arranged deck plan. Enter the boat to a cockpit with forward and aft seating for 6 on the Portside and the wet bar starboard. Moving forward to the helm area, there is a single helm seat and an additional L lounge with seating for 4. Going into the salon there is a fiberglass sliding door with built-in steps for easy access to the bow. The full-size galley is to port in the enclosed head is starboard. The dinette forward converts to a V Berth for sleeping. Aft in the salon is the double wide midship berth.
Breakwater Marina is located, on beautiful Puget Sound, near Point Defiance in Tacoma. We are dedicated to serving the needs of boaters throughout the Pacific Northwest and beyond. Our cruising waters extend from Olympia to the San Juan Islands, the Gulf Islands in British Columbia and North to Alaska. For information and viewing, contact Michael Marchetti, 253-752-6663 Office, Cell 253-381-2173, Email email@example.com
5603 N. Waterfront Drive *at Point Defiance
Tacoma, WA 98407
United States


text:
On this page:
Palaia is a comune in the Province of Pisa in the Italian region Tuscany, located about 45 kilometres southwest of Florence and about 30 kilometres southeast of Pisa.
- also known as Palaia, Italy
- part of Italy, Tuscany, Province of Pisa
- read more about Palaia (city/town/village)
Printed dictionaries and other books with definitions for Palaia
Click on a title to look inside that book (if available):
The Old Testament Pseudepigrapha (2010)
by James H. Charlesworth
Original language The Explanatory Palaia is a compilation from many sources, but nearly all of the component parts of variant redactions go back to the Old Church Slavonic translations made in the Cyrillo-Methodian period, A.D. 863-87, and ...
End of Days (2017)
An Encyclopedia of the Apocalypse in World Religions by Wendell G. Johnson
One major problem is that five of the six Abraham manuscripts have the book incorporated into a larger work, the Tolkavaja Paleja (Explanatory Palaia), an OCS expansion and interpretation of the Hebrew Bible with a distinctly anti- Semitic ...
The Encyclopaedia Britannica (1911)
A Dictionary of Arts, Sciences, Literature and General Information
{Phrygia, Palaia. W. P. C. WILLIAM, PRIDEAUx Court.NEY. Peterborough and Monmouth, See the article: Court.NEY, Baron. Earl of. W. R. M. WILLIAM RICHARD MoRFILL, ...
The New Encyclopedia of American Scandal (2001)
by George C. Kohn
Palaia Ashwinee Sadanand ...
shobDolara My Sylheti Dictionary
by Munayem Mayenin
baTash boysh/boyosh boyshi/boyoshi/burha/briDdho mas dhora/mas maraa kun/kuna firishTa/forishTa raag/gUsa biPoriT/ulta bEsrinkola/bisrikolPonTa bisrinkolabaDi/bisrinkolaPonTi biruP ProTikria Teaag Kora/ Palaia zaowa/ Palai Deowa ...
Historical Dictionary of Leibniz's Philosophy (2006)
by Stuart Brown, N. J. Fox
Palaia, Roberto. "The New System of the Nature of Substances in the Philosophical Journals of the Seventeenth Century." In Woolhouse, Leibniz's " New System," 113—22. Parkinson, G. H. R. "Substantial Forms in the Systeme Nouveau and ...
Encyclopedia of Plague and Pestilence (2007)
From Ancient Times to the Present by George C. Kohn
Palaia Rosalie C.
A dictionary of the economic products of India (1885)
by Sir George Watt
Kedoi' arak', SantaL; SatKiidra- palaia, ...
Online dictionaries and encyclopedias with entries for Palaia
Click on a label to prioritize search results according to that topic:
Photos about Palaia
Click on an item to view that photo:
- Palaia
Photo credit: fdecomite
- Palaia Perithia
Photo credit: cornelia.huck
- Palaia Epidavros, Greece
Photo credit: Anametheus
- Paula Bezerra entrevista o Coronel Palaia
Photo credit: OBORÉ / Projeto Repórter do Futuro
View more pictures about Palaia Fokaia.
Scrabble value of P3A1L1A1I1A1
The value of this 6-letter word is 8 points, but it's not an accepted word in the Official Scrabble Players Dictionary.
Anagrams of PALAIA
What do you get if you rearrange the letters?
See also the blanagrams of Palaia!
Share this page
Go to the thesaurus of Palaia to find many related words and phrases!


text:
Words that end in ainishly
Found 2 words that end in ainishly. Browse our Scrabble Word Finder, Words With Friends cheat dictionary, and WordHub word solver to find words that end with ainishly. Or use our Unscramble word solver to find your best possible play! Related: Words containing ainishly
- Scrabble
- Words With Friends
- WordHub
- Crossword


text:
Posts Tagged 'MySpace'
We Only Want the Freshest MCs
Posted December 10, 2008on:
Jermaine Dupri, the Core DJs and TAG Records are always looking for the finest MCs out there. If you think you're fresh enough, upload your hottest tracks onto our MySpace page, battle to be a Top MC and you could make history. Got it? Cool. Then step up and get in the battle.
MySpace – Q aka Q DA KID
Posted November 9, 2008on:
Visit Q da Kid's Official MySpace page for a look at the artist's life and music!


text:
For those who don't know it, VeraCrypt is the successor of the wildly popular encryption software TrueCrypt, whose development stopped a couple of years ago, apparently after the introduction of the BitLocker functionality in Windows 7 and 8.
The biggest advantage of something like TrueCrypt lied in the fact that it was multi-platform, unlike its Microsoft counterpart. VeraCrypt is also multi-platform (it's available on Windows, Mac and Linux) and has an additional advantage over TrueCrypt, being open source which, for a Security product, is always good news (for those of you who are wondering, TrueCrypt wasn't really open source as it had a very particular license, as you can read in its Wikipedia page).
Anyway, installing VeraCrypt on Windows is very straightforward (it's the typical Next-Next-Next-Finish process), but if you want to use it on Mac OS, you need an additional piece of software to make this work (not that it makes the process any more difficult anyway, but still it's good to have here for reference).
What you will need
Some of you might remember FUSE for OS X as that software necessary to acquire write capabilities on NTFS drives on a Mac machine. We will need it to use VeraCrypt and manage its encrypted volumes.
Installing VeraCrypt on Mac OS X
- Install Fuse for OS X first, and make sure you select the MacFuse Compatibility Layer option when prompted. By default, this is not selected.
- This is fundamental. If you skip this part, the VeraCrypt installer will complain later about this feature missing and installation will abort.
- Continue until the end of the installation process and enter your password when prompted to do so to complete the installation.
- You can now proceed with the installation of VeraCrypt without issues, as there are no options to choose from during the process.
You can now launch VeraCrypt and have all of its encryption goodness at your fingertips.


text:
With RSS feeds, you don't have to visit our site everyday to keep up to date. Simply subscribe to our blog via RSS or Email and our latest posts will come to you!
I just wanted to take a minute to THANK all of my customers, prospects, employee's (both past and present), vendors, friends and family for another wonderful year here at Agency 10 Insurance. I wish all of you and your families and … Continue reading


text:
Regarding the Swarovski 80 mm STS HD Spotting Scope: what is the difference between the STS and the STM scopes?
Thank you!
Hi Delphi,
Thanks so much for your inquiry.
The now discontinued STM and ATM bodies were made of magnesium. The current ATS and STS scope bodies are made of aluminum. The color of the focus wheel on the ATM/STM is green; they changed that to black in the newer ATS/STS models.
If you have any further questions, please let me know!
All the best,
Eagle Optics


text:
Show Summary Details
Quick Reference
Title given to fragments of an epic poem of the 9th c. written in Old Saxon alliterative verse (Stabreim). The view that its author also wrote the Heliand has been ...
Subjects: Literature.
Related content in Oxford Index
Reference entries
Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.


text:
Common law marriage in Spain
There is no "common law" marriage in Spain, that is, a couple may live together for many years as man and wife and have children together, but this establishes no legal rights for either the man or the woman.
If the man dies, the woman has no claim to inherit any share of his property or to collect his pension. In the eyes of the law, there is no legal relationship. Unless the man formally recognises the children as his own, he is not required to bequeath his property to them.
The law regards these children as offspring of a single mother. Their births must be registered as such and they take their mother's two last names because she is their only legal parent.
If the unmarried father of the children chooses to leave parts of his estate to his unrecognised children, they will not have the right to apply the lower inheritance tax rate enjoyed by children of married parents, except in some autonomous regions, such as Andalusia.


text:
Symposium Co-Chairs
Confirmed Invited Speakers
Symposium Sessions
Monday June 16
|Advanced Manufacturing Keynotes
|Sustainable Nanomanufacturing I
|Sustainable Nanomanufacturing - Posters 4:30
Tuesday June 17
|Sustainable Nanomanufacturing II
Symposium Program
Monday June 16
|↑ Back to Top
|Advanced Manufacturing Keynotes
|National Harbor 5
|Session chair: Fiona Case, NSTI, US (bio)
|An Innovation-Driven Strategy for Advanced Manufcturing (invited presentation)
W.B. Bonvillian, MIT Washington Office, US (bio)
|Addressing U.S. Advanced Manufacturing and Clean Energy Technology Challenges (invited presentation)
R.W. Ivester, DOE EERE Advanced Manufacturing Office, US (bio)
|Chemical manufacturing challenges of advancing micro- and nanoelectronic technologies into mass production (invited presentation)
J. Dalvi-Malhotra, Brewer Science, Inc., US
|3D printing: How emerging materials, applications, and business models will disrupt manufacturing and enhance future innovation
A.C. Vicari, Lux Research, US
|↑ Back to Top
|Sustainable Nanomanufacturing I
|National Harbor 2
|Session chair: Ahmed Busnaina, NSF Nanoscale Science and Engineering Center for High-rate Nanomanufacturing (bio)
|Frontiers of Nanomanufacturing (invited presentation)
J.A. Liddle, National Institute of Standards and Technology, US (bio)
|The 2014 NCMS-NSF Survey of Nanotechnology in the U.S. Manufacturing Industry
M. Mehta, National Center for Manufacturing Sciences (NCMS), US
|Nanomanufacturing: The Making of the Materials Revolution (invited presentation)
T. Earles, Lockheed Martin Corporation, US (bio)
|Nanoscale Offset Printing (invited presentation)
A. Busnaina, NSF Nanoscale Science and Engineering Center for High-rate Nanomanufacturing (NSEC), Northeastern University, US (bio)
|Continuous Extrusion Process for Preparation of Polymer Nanocomposites
J.D.M. Shearer, C.M.F. Barry, J. Mead, University of Massachusetts Lowell, US
|TBA (invited presentation)
M. Lilly, Northrop Grumman Corporation, US (bio)
|Environmental Net Benefit of Quantum Dot Components for Displays (invited presentation)
S. Coe-Sullivan, QD Vision, US (bio)
|↑ Back to Top
|Sustainable Nanomanufacturing - Posters 4:30
|Expo Hall C
|Novel Additive Manufacturing of Tooling with Micro and Nanostructured Surfaces
L.W. Sit, M. Kumbhani, J.A. Genera, J. Shearer, J. Mead, C. Barry, University of Massachusetts Lowell, US
|High-rate Manufacturing of 3D Products with Micro and Nanostructured Surfaces
C. Barry, J. Mead, University of Massachusetts Lowell, US
|Nano Particles formation on powder(NPP) Substrate in Physical Vapor Deposition
S-K Koh, C. Lee, J.H. Lee, B.K. Kang, H. Kaji, M. Hayashi, GL Materials, Inc., KR
|Preparation of Composite of ZnS Nanoparticles and Montmorillonite by Cavitation Deposition
P. Praus, R. Dvorský, L. Svoboda, B. Kostura, VŠB-Technical University of Ostrava, CZ
|Three-Dimensional High-order Nano-rod Formation Using a Hydrogen-assisted Deep Reactive Ion Etching
S. Soleimani, S. Zanganeh, S. Azimi, Z. Sanaee, S. Mohajerzadeh and H. Taghinejad, University of Tehran, IR
|What is Below the Support Layer Affects Carbon Nanotube Growth: an Iron Catalyst Reservoir Yields Taller Nanotube Carpets
E. Shawat, V. Mor, L. Oakes, Y. Fleger, C.L. Pint, G.D. Nessim, Bar-Ilan university, IL
|High-yield synthesis of "floating" three-dimensional carbon nanofiber mats using controllable substrate-catalyst detachment
E. Shawat, I. Perelshtein, C.L. Pint, G.D. Nessim, Bar-Ilan university, IL
|Green Chemistry of Carbon Nanomaterials
E.V. Basiuk, V.A. Basiuk, Universidad Nacional Autónoma de México, MX
|A Sustainable, Mechanochemical Synthesis of Nanoparticles Supported on Lignin
M.J. Rak, T. Friščić, A. Moores, McGill University, CA
|Electrospun Nanocomposite Nerve Guidance Conduits for Peripheral Neural Regeneration
W. Zhu, L. Zhang, The George Washington University, US
|Roll-to-Roll (R2R) ALD Thin Film Coatings at Atmospheric Pressure
M. Groner, J. Spencer, K. Buechler, ALD NanoSolutions, US
Tuesday June 17
|↑ Back to Top
|Sustainable Nanomanufacturing II
|Chesapeake 7-9
|Session chair: James Alexander Liddle, NIST; Michael Meador, NASA
|Graphene Ready For Prime Time (invited presentation)
J. Lettow, Vorbeck Materials, US (bio)
|Advancements in Microelectronics-Grade Carbon Nanotube Materials for NRAM® Device Manufacture and Analysis of Carbon Nanotube Mass in End User Devices (invited presentation)
J.E. Lamb, S. Gibbons, R. Trichur, Y. Jiang, K. Mangelson, K. Kremer, D. Janzen, Brewer Science, Inc, US
|TBA (invited presentation)
D. Arthur, SouthWest NanoTechnologies, Inc., US (bio)
|Industrialization of Boron Nitride Nanotubes: From Synthesis to Applications
K.S. Kim, M.B. Jakubinek, A. Hrdina, Y. Martinez-Rubi, B. Ashrafi, M. Plunkett, S. Lin, S. Denommee, C.T. Kingston, B. Simard, National Research Council Canada, CA
|Fluidic Devices for Nanoparticle Manufacturing (invited presentation)
S.M. Stavis, National Institute of Standards and Technology (NIST), US (bio)
This symposium will highlight challenges and opportunities related to Sustainable Nanomanufacturing and progress towards addressing them. In addition to oral presentations, a special poster session will be held where participating federal agencies will discuss Nanomanfacturing related programs, resources and facilities.
√ Nanotech Conference & Expo
√ Microtech Conference & Expo
√ Cleantech Conference & Expo*Sponsorship Opportunities: Contact Chris Erb