text: I am new to flash kits, and I have just purchased a DSi, waiting for it to be delivered. After reading that the Action Replay DS wont work on the DSi, I began reading on flash cards, that the Acekard 2, and Acekard21 support Action REplay codes. And my question is, do those codes only work for games that are being loaded while the acekard is in, or will it work like an action replay ds does now where I load the codes then I can insert my own DS game and the codes will work for it. For example pokemon games. My other question is, can you play romz of games. I hope this is an ok question to ask but I am ordering my Ackard2i with an 8gb MicroSD HD card and was wondering if I would be able to just put all the games I own on that card instead of having to bring each individual cartridge?


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Amy Schumer
Bellco Theatre
700 14th St.
Denver, CO 80202
Bellco Theatre
700 14th St.
Denver, CO 80202
The boundary-pushing comedian-actress-writer-producer brings all her talents to the table in her popular Comedy Central television series, Inside Amy Schumer. The Train Wreck star's provocative—and often wicked—wit is on display again in her standup tour as she explores her usual cadre of topics: sex, relationships, love, and the weirdness of being an adult(ish) person right now. Sat 7, 10 p.m.
—Image courtesy of Amy Schumer Live
Visit amyschumer.com.
- Category:
- Performing Arts
- Date:
- Nov 05, 2016 07:00 pm - 10:00 pm
- Cost:
- $43-$113.

subset: commoncrawl


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Stock Cartoon of a Chubby Drunk Monk with Beers
Cartoon Clip Art © Cory Thoman
Royalty free stock cartoon of a chubby drunk monk with beers. This friar stock cartoon image #28257 was designed by Cory Thoman. Please note: this image is protected by copyright law and may not be used without buying a license. To acquire the license simply click on the 'Download Digital File' button.


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Archive for the 'Health' Category
Progesterone levels during Pregnancy
When a woman is pregnant having enough progesterone in her body is important. It helps to transform the size of the uterus to accommodate a full size baby. Estrogen also plays an important role. Both hormones are crucial, so that, a woman can undergo a successful pregnancy.
Relieving hormonal imbalance to increase progesterone levels during pregnancy with exercise can be hard for a pregnant woman. After 6 months, the uterus has grown to accommodate the baby. Therefore women are a great risk should they perform vigorous exercise during pregnancy. A good balance of hormones is important to achieve a healthy and safe pregnancy. Eating well and checking with your doctor are things that a woman can do when she is no longer able to exercise. A doctor can recommend supplements to relieve low progesterone. Wild yam cream is one supplement that can help a woman increase progesterone production naturally and restore the body's normal hormonal balance between progesterone and estrogen.
Recommends to check out more information on progesterone levels and successful pregnancy.
Reduce Fibromyalgia Symptoms
It is very vital to discover fibromyalgia in time so that it can be treated appropriately in order to reduce or totally eliminate the symptoms and unwanted side effects. Muscular pain is one of the symptoms identified with fibromyalgia and it can be very excruciating, radiating and burning. Other fibromyalgia symptoms include confusion, unstable blood pressure, nausea, lack of appetite, diarrhea etc. If all these disorder mentioned are not take care of on time, it will degenerate to other serious systems that can endanger the lives of the people affected.
So far, what causes fibromyalgia is not yet known, but many treatments are available for it to enhance daily activities of the patients.
Yalila Moreno try alternative therapies like acupressure or yoga to reduce fibromyalgia symptoms and muscle pain in the joints and tendons.
Forms of Testosterone Supplements for men
Testosterone supplements are an anti-aging therapy for men with deficient levels of the hormone. Testosterone supplements are generally available in three formats: pill, gel and booster. Testosterone injections are another kind of treatment which is the very fast acting. This is because the hormones are injected directly into the bloodstream and take effect within hours of the injection.
Natural testosterone boosters do not contain hormones. Instead they help to boost testosterone on the body. They work by suppressing production of estrogen or help to boost the production of the testosterones. Natural boosters may also contain plant sterols which increase the hormonal levels found in men. Natural boosters are found in plants, herbs, vitamins and minerals. Boosters are blended with different herbs and minerals and available in pill form.
Testosterone gel is another for a supplement that is fast acting. The gel is applied to the skin and quickly absorbed into the bloodstream.
Safe Herbal Anti-Menopause Dietary Supplement: Estroven
Estroven is different from the usual anti-menopause supplements since it contains a more comprehensive range of herbs aimed at promoting overall better female health apart from correcting menopause symptoms induced by menopause.
Estroven contains a potent herbal mixture that seeks to correct problems like mental fatigue, disturbed sleep, extreme mood swings, body pains and recurring fluctuations in body temperature. It is fortified with many rare minerals like Calcium and Boron. Calcium supplementation is vital for menopausal women since they have a disturbed calcium metabolism. Here, calcium isn't fully absorbed that impairs proper bone regeneration, making the bones softer—a condition called Osteoporosis. Boron is required for ensuring comprehensive uptake of calcium. This herbal supplement is impressive since its soy extracts are aimed at stimulating the natural production of estrogen hormone in the female body, meaning the product doesn't seek to induce dependency but promotes correction of disturbed hormonal balance in the body.
Why Estrogen dominance is essential to our body
Our bodies are made of hormones which contribute to each aspect of our growth. The major common hormone is estrogen dominance which is found in men and women. This intriguing hormone plays different roles in the two genders. This hormone has been known to be more effective in women than in men. People develop various changes of body character at different stages, from a child to a teenager till one becomes an adult. Men and women differ in body character. Estrogen is high in density in women. It enhances the physical change of a woman from the bone structure to the whole figure. Furthermore, it also attributes to the development for sexual characteristics for women since it is the main sex drive hormone. This chemical reaction takes place in the body in different timings and differs in effect depending with one's age. The efficiency could be high or low depending with the state of the woman.
Author recommends to check out more about estrogen levels and low estrogen symptoms.
What are Muscle Diseases
What are Muscle Diseases?
Muscle Diseases are also called myopathies. Many kinds of muscle diseases exist and they are widely grouped as Primary & Secondary muscle diseases. Primary muscle diseases are essentially myopathies where the muscular action is impaired by any irregularity among the muscles, such as metabolic activities responsible for maintaining basic nutrition supply for the muscles.
Secondary muscle diseases are myopathies that are precipitated due to another, principal cause such as problems in the nervous system that affects the action of the voluntary muscles. Different types of muscle diseases have been list below:
- Metabolic Muscle Diseases
- Neuromuscular Diseases
- Inflammatory Myopathies
Natural Progesterone
The term 'Natural Progesterone' refers to the hormone-Progesterone that is produced by the ovaries among females. Though progesterone is also synthesized among males in scant quantities, it plays a far more significant role in the metabolic, sexual and reproductive health of women and is thus, considered primarily a female hormone.
Natural progesterone is first produced around the teenage years in females and from here on, its overall concentration tends to rise steadily until the woman reaches the age of 45 years, i.e. from here on, the natural progesterone levels begin to dip as the woman enters menopause. Progesterone is the chief hormone responsible for regulating the menstrual cycles in women. It is produced in high concentrations during the early part of menopause and its concentration decreases as the woman nears ovulation and after the ovum or the female egg is released at the end of ovulation, natural progesterone levels tend to dip dramatically.
It should be noted that though many progesterone aids aim to replicate and promise to deliver a formulation that is at par with natural progesterone but most of these products cannot compete with the complex and unique biochemical formula that is at the heart of this critical, fertility hormone. Apart from the ovaries, natural progesterone is produced in scant quantities by the adrenal glands. Sufficient amounts of natural progesterone are important in the body since it is also the natural precursor for the balancing of other female hormones like Estrogen.
You can check out more information on progesterone.
Review on Hair Restoration
They say that hair is the crowning glory in a women but what if suddenly you experience hair fall and eventually leads to baldness? Thinning hair is the problem of several women today. Men also do experience such thing. Hair loss is common to both sexes.
Every one losses a certain amount of hair every day due to several reasons. If you have a healthy scalp, your hair will grow back and replace the loss hair. But what if it didnt grow back? Hair restoration is your option.
Hair restoration is one answer to thinning and balding problem.
There are lots of hair restorations that you can use if you are encountering this kind of problem. Hair treatments are widely available today. Some of these treatments involve the use of preparations which is taken orally such as pills and tablets. Others are offering external treatments which are applied and rubbed into the scalp. There are over the counter products that can be bought at the pharmacy.
Hair transplant is one way to get to grow your hair back. This method is expensive and mostly ordinary people cannot afford this kind of treatment.
Some people prefer the natural hair restoration method. They believe that this method is the best and safest way in combating hair loss. It might take some time before you see the results but it will be worth the wait.
Experts say that vitamins, herbs and even diet can help women to cope with hair loss. Eating healthy foods will not only help you deal with hair loss but will make you healthy also inside and out.
Finding the best hair loss products can take time. It is always best to consult your doctor before trying anything. What works for other people may not necessarily work for you.
You can check out more details on utah cosmetic surgery.
Symptoms of lung cancer
Lung cancer, like other forms of cancer is a breakdown of the cell balance maintained by our bodies. A system of checks and balances are maintained by the human body to generate new cells only when need. When this system is disrupted, cells grow uncontrolled to form a mass called a tumor. A tumor can be malignant or benign. A benign tumor is relatively harmless and does not spread. A malignant tumour, on the other hand, spreads to other parts of the body aggressively. Lunch cancer can either be small lung cancers (SCLC) and non-small lung cancers (NSCLC). Both these types of lung cancers spread differently.
In terms of symptoms, lung cancer can many times be detected during a routine chest X-Ray or CT Scan. The X-Ray or scan will show a solitary mass called a lesion. Patients with small lesions usually do not have any external symptoms. The presence of a lesion will usually lead to a series of tests to see if the lesion is benign or malignant.
A simple physical examination can also lead to the presence of lung cancer. If the patient is a regular smoker, doctors will look for signs such as breathing difficulties, obstructions or infections in the lungs. If the lung is deceased, insufficient oxygen in the blood will appear as a bluish colouring of the skin, a state call Cyanosis.
The growth of lung cancer will interfere with breathing, and lead to symptoms such as cough, shortness of breath, wheezing, chest pain, and coughing of blood. If the cancer invades nerves, it may lead to shoulder pain or paralysis of the vocal cords. Esophagus could also be affected making it difficult for the patient to swallow.
Lung cancer can also spread to the bones and is called metastasis. This will cause severe pain in the bone joints starting with the shoulder and moving to other parts of the body.
Lung cancer can also affect the brain, causing blurred vision, headaches, seizures, or weakness in sensation.
Then there is the Paraneoplastic Symptoms which result from the production of hormone like substances by the tumor. The most common type of harmone is called adrenocorticotrophic hormone (ACTH). This results in elevated levels of calcium in the bloodstream.
There could also be other symptoms such as weight loss, weakness, fatigue, depression, and mood changes.
Author also likes to share details on breast cancer statistics. You can also check out about breast cancer donation.
What Are FSH Levels
FSH — Follicle Stimulating Hormone, is the most vital sexual well being hormones in between females and males. However, in women FSH levels are far more crucial for ensuring appropriate reproductive health. FSH levels have a tendency to rise inside puberty stage onwards. FSH is responsible for some fundamental reproductive well being processes such as ovulation and menstruation in women and maturation of sperm in between men.
FSH levels are generally checked through normal urine and blood tests. One of the most common causes for conducting such diagnostic tests include delayed or premature onset of puberty traits. It has been established that FSH levels have a tendency to change in conjunction with Luteinizing Hormone or LH levels. These 2 hormones are principal responsible for ensuring appropriate ovulation and menstruation apart from doing sure how the female is able to sustain her pregnancy. Women who are about to reach or have entered menopause have a tendency to acquire higher than usual FSH levels. This makes it nearly impossible to conceive in a natural, unassisted manner.
Usually, LH and FSH levels have a tendency to rise exponentially from puberty onwards until the age of 40 years and inside age of 45 years onwards, the level of FSH tends to dip seriously with each progressing year. Apart from infertility, causes for which FSH level diagnostic tests is ordered include other hormonal disorders, such as Estrogen Dominance in between women. This really is because disturbed FSH levels have a tendency to impair the overall hormonal balance of reproductive/sexual hormones.


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Third Annual Railroad Square Music Festival: June 11, 2017
Sonoma County boasts a vibrant music scene, with the extra bonus that many concerts are free to the public. As the organizers of the Railroad Square Music Festival, one of the area's most popular events, explain, "the mission is to expand our local music community by bringing more music to new people, to encourage our local performers to shoot for the stars, and to show that the North Bay is a vibrant cultural and artistic hub."
Stars, indeed. So on Sunday, June 11, from noon to 7 p.m. music lovers of all kinds are invited to attend – for free – this celebration of the North Bay creative community being held in the heart of Santa Rosa. And because "free" isn't enough of a community gift already, RSMF proceeds will benefit West End Farmer's Market's EBT matching program, which is a 501c3 where patrons can double their EBT funds up to $25 to purchase locally grown organic produce.
Among its many highlights, the festival features the release of the Out There Sessions compilation CD, recorded at musician John Courage's all-analog Gremlintone studios in Santa Rosa. The album features 13 local performers, many of them RSMF alumni who are coming back as performers this year.
The line-up includes David Luning, John Courage, female lead powerhouses B and the Hive (formerly Girls & Boys), La Gente, Lungs and Limbs, Sharkmouth, Swingin' Dixie, Earles of Newtown, the Timothy O'Neil Band, soul trio Token Girl, and several local acoustic performers.
To keep the party going, guests can purchase "hoppy fuel" from Petaluma's Lagunitas Brewery, or Russian River Valley wines from Virginia Dare Winery, plus food from the West End Farmers Market. And because the event is family friendly, there will picnic areas, plus a stage for Sonoma County's premier circus troupe Circus Maximus.
Details: railroadsquaremusicfestival.com


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A Maghull Labour councillor is urging people in the western part of the town to have their say in Sefton Council's consultation on proposals to introduce 20mph speed limits on roads throughout the area.
Residents are being asked to give their view on the plans which would see a reduced speed limit on residential roads to the east of Northway, Liverpool Road North and Southport Road.
Sefton Council is having a drive to improve safety on the borough's roads by increasing the number of 20mph speed limit zones.
Before the decision is made whether the speed limit should be reduced on certain roads, or what roads should be changed, Sefton Council is conducting a survey of residents.
But time is running out for residents to have their say, so Maghull Town Council Labour councillor and newly elected Park Ward Labour councillor June Burns is urging people to have their say.
Cllr Burns said: "We all obviously want our roads to be safer, but how we make them safer is something that people who live in the roads need to be given the chance to decide on.
"That's why Sefton Council is holding this consultation, to ensure that residents have a say.
"For some, 20mph speed limits will be great, for people who live in other roads, 20mph wouldn't be appropriate. These are the details that the consultation will draw out.
"But people need to take the time to take part in the consultation."
Cllr Burns urged people to return the consultation document.
Cllr Burns said: "Every household should have received the consultation document, but if you didn't, then you can make representations online via the council website.
"The deadline for responses is this Friday (July 4) so time is running out. But please do take the time to take a look at the proposals and documentation and have your say.
"As a resident of Maghull I strongly believe that decisions affecting our community need to be made by the people who live here. This consultation allows us to do just that."
The deadline for the consultation is Friday, July 4. To see the documentation and to have your say go to www.sefton.gov.uk/trafficschemeconsultations


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If you are a barrister who wants to become a solicitor, see details below of what you need to do to be admitted to the roll.
Barristers who qualified in Ireland can transfer to become solicitors without the necessity of undergoing the full training programme prescribed for trainee solicitors - per Section 51 of the Solicitors (Amendment) Act, 1994.
You can apply if you have been called to the Bar of Ireland and for a minimum of three years have:
Your application consists of sending the following documentation and fee to the Law Society:
Send all required documentation and supporting information as detailed above, plus payment, to:
On receipt of the above documentation, the applicant may be called for interview by representatives of the Law School.
The next step is referral of your application to the Education Committee for a decision on whether the applicant is eligible to be admitted to the Roll of Solicitors and what conditions, if any, may apply. The Education Committee meets approximately 10 times annually.
All applicants are required to attend the next Essentials of Legal Practice course (ELPC). The deadline for receipt of applications for the Essentials Legal Practice Course is 12 June, 2018.
This course runs annually in August and/or early September each year.
The 2018 ELPC will run from Monday, 20 August until Friday, 7 September 2018 inclusive (weekdays only) - these dates may be subject to change.
The ELPC covers Professional Conduct, Solicitors' Accounts, Probate and Taxation and Conveyancing. Attendance at all modules is compulsory. There is no examination. The fee for the 2018 ELPC is €2,830 (bring your own iPad) or €3,100 (iPad mini included).
Applicants may be obliged to spend up to a maximum of six months in the office of a practising solicitor, for the purpose of receiving due instruction and obtaining experience in the practice and profession of a solicitor. This six month requirement may, in exceptional circumstances, be waived/modified - this is a matter for the interviewing panel and the Education Committee.
On completion of any in-office period, the applicant will be required to submit a letter from the practice confirming the period worked, whether it was full-time, the experience obtained and whether the work done was equivalent to that of a solicitor.
On completion of the ELPC, the in-office period and on satisfaction of any other conditions outlined by the Education Committee, the applicant may apply to be admitted to the Roll of Solicitors. The fee for enrolment is €300.
Download the privacy statement for admission to the roll.
Further details may be obtained from Dr. Rachael Hession, Law School, Law Society of Ireland, Blackhall Place, Dublin 7.Tel: 01 8815707Email: email@example.com


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KGHM Metraco S.A. is a seller of rock-salt mined by KGHM Sól. It has been extracted at the "Polkowice-Sieroszowice" Mining Facility since September 1991. The annual excavation output amounts to an estimated 1 million tons. KGHM Sól is characterized by a high NaCl and microelement content. It may be used in industries and market sectors including chemistry, foods, heat generation, dyeing, tanning, feed for animals and winter maintenance of roads
For detailed information on the offer, please visit www.kghmsol.pl


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God is never lost. In the midst of great evil, God is there. I have long wondered how Jonestown fits into such ideas. In the 1970s, Rev. Jim Jones and the Peoples Temple founded the settlement in the jungles of Guyana. After a few years of communal living, Jones led his followers to commit a […]
#51 / Jonestown Theology: Lenten Explorations in the Valley of Death
March 30, 2017 by
God Damn these Hate Crimes and the Institutions that Fail to Act to Prevent Them
November 2, 2015 by
Just a few months ago, trans woman of color Shade Schuler was murdered in this community. Shade's body was in a field over in the Medical District so long that it was difficult for the police to identify her when someone cutting grass found her. We forgot about Shade. When I heard about the horror […]
The Premeditated Murder of Lester Bower
June 2, 2015 by
God is in Hell
July 27, 2014 by


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Posts tagged with Video
A day in the life of... a motion designer
We're in the land of the creative for this week's 'day in the life'.
Lisa Ferrari is head of motion design at Silver Agency, a B2B specialist. We caught up with here to ask about her motivations and inspirations.
Ask the experts: Paid social media trends, challenges & strategy
Next up for our 'ask the experts' series is paid social media.
We've got some consultants and agency bods to give us their opinions on everything from Snapchat to strategy, video to influencers. There's quite a lot to digest so you can use the hyperlinks below to jump between questions.
A day in the life of... Head of Video at an agency
Video. The bête noire of marketers and advertisers. When it's good it's really good, when it's bad it's really bad.
Thankfully, there are at least a few in the industry that understand the medium in great detail. Abigail Howson, Global Head of Video at Jellyfish, is one of them.
Four ways marketers can increase conversions from social video
Brand videos now regularly feature in social media feeds, as marketers increasingly use the medium to engage consumers on Facebook and Instagram.
However, video can do more than increase general engagement on social platforms themselves.
61% of retailers offer 'lean back' content. But can retail brands succeed with 'TV shows'?
The main opportunity for brands to reach consumers via TV used to be advertising.
Now, thanks to the rise of digital streaming services, more and more brands are making TV-style content of their own.
Five successful brands on YouTube: From Adidas to Sarson's vinegar
When you think of brands on YouTube, you might automatically think of pre-roll ads or sponsored vlogs.
But this is just part of the story. Many big brands now recognise the power of creating an effective video marketing campaign specifically for the platform, with the best examples helping to build brand communities, further engagement across all social channels, and increase sales.
SME case study: How an auction house added Facebook Live to its digital strategy
A regional auction house might not sound like the most obvious example of digital transformation. However, Simon Charles Auctioneers has demonstrated how being digital-first can generate big results - even for the smallest of companies.
In the past year, the auction house has transferred its offline marketing activity online, using a combination of video content, social media and email marketing to target consumers.
Stories from SXSW 2017: ad blocking, content distribution, and Joe Biden
Although there will be plenty of summaries coming out of SxSW Interactive 2017, many of these will address broad trends and themes, without digging into the detail of specific sessions.
Because of this, I thought it would be interesting to provide a summary of some of the interesting debates I attended last week.
How travel brands are capitalising on YouTube adventure search trend
A new report by Hitwise has highlighted how travellers are increasingly searching for videos related to adventure destinations on social media.
For travel brands, this means greater opportunity to engage and capture consumer interest.
2016: The good, the bad and the future of digital marketing
It's not quite over yet, but 2016 has been busy. As I predicted last year, mobile has been a definite focus for almost every marketer and we're slowly starting to see VR and wearable technology take off.
I've found it interesting to see how businesses have started to scope out new and creative ways to incorporate all of these technologies and opportunities into their marketing strategies.
Facebook: A handy roundup of its latest developments and commercial opportunities
Although it is nearly seven years since Time Magazine observed that Facebook was 'the site that ate the internet', in the intervening years the social network has only increased its influence in the digital space and beyond.
How Barclays transformed its video content strategy
How has Barclays used video content to regain relevancy and trust?
Mark Brayton, content marketing director at Barclays, spoke at the Festival of Marketing on the transformation of Barclays' video strategy.


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Plot No. 32, Sector 5, IMT Manesar, Gurgaon, Haryana 122052, India
Email: firstname.lastname@example.com
For collaboration/partnership/services/feedback, we would like to hear your thoughts
LeadInvent has developed unique molecule simulation platform (christened LIDiscoverEngine). This simulation platform enables scientist to design and study molecules virtually on supercomputing platform before such molecules are synthesized and tested experimentally. This capability of virtual design and testing saves considerable experimental cost and reduces discovery time. More over LIDiscoverEngine provides atomic level insight and unravels the energetics of binding for a protein ligand system. This unique capability guides scientist to discover drugs through a rational approach rather than conventional hit and trial.
Understanding atomic level contacts, define essential pharmacophore , carve out unoccupied space within active site, suggest changes on molecule without affecting binding.
Estimating accurate binding between a target protein and small molecule is pivotal.
Built upon iterative experimental feedback, LeadInvent has developed unique simulation methodology and mathematical grading (scoring) functions that accurately docks and predict binding of a molecule to its target protein.
Predict experimental IC50 Prioritize synthesis of molecules
Accurate binding energy scoring is central to a simulation that predicts protein ligand interaction. However most current simulation methods rely on mathematical approximations to generate such scores.
LeadInvent's binding energy scoring platform is a unique approach. Our method is at the interface of quantum calculation and molecular mechanics. This has enabled us to estimate binding energies with unmatched accuracies and strong correlation with experimental IC50's.
The graph here depicts accuracy of a leading simulation software in comparison to LeadInvent's simulation package (LIDiscoverEngine). Each dot represents a molecule and its relative energy value predicted by respective simulation software. X axis represents experimental IC50 values for each molecule and Y axis represents the software predicted values.
It is quite evident that the prediction from the leading software is scattered with no correlation with experimental values . Where as results from LIDiscoverEngine are highly grouped. Because of such strong correlation between LIDiscoverEngine and actual experimental results. LeadInvent can upfront estimate potency of molecules even before they are chemically synthesized and tested. The dot highlighted with the red circle in the LeadInvent data graph was also successfully predicted by LIDiscoverEngine as a molecule with poor conformation to target protein.
Proteins are complex three dimensional bio molecule made up of hundreds of thousands of atoms. Typically a 3D structure of protein could be understood from crystallography technique. While this technique provides very useful information about a protein and its over all 3D shape. It typically represents one of the many low energy conformation available to a protein. Protein molecules are flexible bio molecules and subtle changes in their conformation dictate major functional roles for them. Hence while working with proteins as drug targets. It is important to have tools and capacities to understand and work with different conformations of a target protein from a drug design perspective. LeadInvent has developed extensive expertise and technology to simulate and handle various conformations sampled by a target protein. This capability of LeadInvent has been used extensively across multiple discovery programs executed by the company and has unraveled key understanding in such programs.
Case Study: LeadInvent worked on a target protein for which the data is represented above. According to experimental results. The mutated protein has a 20X higher activity for its substrate than the native protein. However the reason for such higher activity was unexplained. The graph here depicts different conformations of this target protein (average RMSD) . The red graph represents different conformations of the protein carrying the single amino acid mutation (mutated protein). Where as the black graph depicts native protein without mutation. The two protein conformations are shown in the panel to the right. It is clear that the mutated protein attains a specific conformation that opens up the protein structure giving early clue to the 20X higher activity of the protein for its substrate. This case study highlights the necessity for deconvulating protein conformations and establishes the capabilities of the team to use such information in its drug discovery endeavors
Small molecules are generally flexible molecules with certain degrees of freedom around their rotatable bonds. Because of this inherent structural freedom a molecule could exist in multiple shapes (conformations). When molecules are free (not bounded to their target proteins) they are able to sample multiple different confirmations. Where as when molecules are bound to their target proteins. They are restricted by the target protein and hence molecules exist in limited conformations.
LIDiscoverEngine provides key insight into such studies and guides scientist in designing conformationally stable molecules.
Here two molecules were designed and tested for activity against a target protein . The two molecules were almost identical except a single atom change at position A1 and A2. Compound with A1 change reported and experimental IC50 of approximately 50 nM where as compound with A2 change was found to have IC50 greater than 1 uM. In the right image panel unbound molecules are depicted by red ice sickle where as bound molecule conformations are depicted by green ice sickle.
It is clear that molecule with A2 change has almost 50% of the unbound molecule prearranged in the conformations that overlaps with the protein bound state. Where as molecule with A1 change has less than 10% free molecules conformations that over lap with bound conformations.
This clearly points out the subtle conformational energetic penalties paid by molecules as they go form an unbound state to a bound state and dictate their activity profile against a protein target.
Red well represent unbound molecule conformations. Green well represent the protein bound conformations of the same molecule
One of the biggest challenge in drug discovery is to design and develop molecules that selectively show activity against a particular target protein. A possible solution to this is to test activity of molecule across multiple targets for possible cross target activity. While experiments take several weeks and cost tens of thousands of dollars for testing cross target activity of molecules. LIDiscoverEngine is able to virtually simulate and test activity of a molecule across 8000 proteins within a single day. Built on top of 1 million literature reported bio activity data points for small molecule. This module of LIDiscoverEngine has been extensively tested.
Kinases are important proteins that act like molecular switches regulating important cellular functions making them important drug targets. However kinases are very similar to each other and share a common drug binding site (ATP binding site). Because of high similarity among different kinases it is known that kinase inhibiting molecules show activity across multiple kinases. LeadInvent team tested over 14 different kinase compounds and successfully predicted activity of all 14 molecules across 400 + kinases with an accuracy of ~ 80% when compared to experimental data.
A red dot depicts a kinase for which the test molecule shows experimental activity less than 10 uM.
A Blue dot depicts a kinase for which LIDiscoverEngine predicts activity of a molecule.
Whenever simulation technique predicts activity of a molecule against a kinase as predicted by experimental studies. Blue dot over lap the red dot. Hence each overlap of red and blue dot confirms computer prediction of experimental result.
A Red dot depicts a kinase against which CHIR265 has been experimentally reported to be active. The blue dot depicts a kinase against which LIDiscoverEngine has predicted activity of CHIR265. It is clear ( from the overlap of blue and red dots) that LIDiscoverEngine is able to predict activity of Chir265 across multiple kinases with above 80% accuracy
LIDiscoverEngine has built in module to screen large number of virtual molecules against a target protein. Implemented on a supercomputing architecture this technology harnesses the power of parallel computing along with seamless connectivity across LeadInvent's multiple simulation modules such as automated ligand preparation, protein conformation generators, parallel docking, and scoring among others.
LeadInvent currently maintains a virtual library of over 8 million compounds that are screened against a target for finding early hit compounds, define pharmacophore of binding and predicting chemical space suitable for a given proteins active site.
This technology focuses scientist on testing only the promising molecules saving significant cost and efforts as compared to hit and trial screening.
This module was used by LeadInvent for a Boston based cancer research company and resulted in 24 hit compounds that were reported positive in experimental studies.
LIDiscoverEngine combines the power of building novel molecules by attaching small molecule fragments along with unmatched parallel processing algorithms. Building block by block from over 2500 small molecule fragments. This technology build molecules in an automated fashion from within the active site.


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In a recent blog I discussed the incredible value that has been created by helping people communicate in new ways (e.g., inventions like the telephone, TV, AOL and Facebook). In this blog I follow up with two factors intrinsic in creating that value, personal connection and slipperiness.
Personal connection is something you should always try to include in your content, as it's a main ingredient in generating readership. Think about the content you now post, for example a notification about the enrollment period for the 401k program. By itself that's pretty dry stuff, particularly if it looks exactly like every other memo of that type.
But you can make it much more effective if you connect the reader to the subject. One way of doing this would be to call out that matching part of your 401k program (assuming you have one) that gives the employee a 100% return on that portion, in effect doubling their money instantly. Or how about a piece about a recent retiree who bought a cottage or boat with part of their savings? These treatments bring a dull subject alive and make the reader really start thinking about the subject.
Slipperiness is also important. What I mean by this is the reader's ease of finding and consuming the message. When TV was rolled out in the late 1940's it became an instant success because advertisers loved how easy it was to get people to watch their messaging. The reader didn't have to open a magazine or drive past a billboard… they didn't have to do anything except sit there and watch the tube. The advertisers could slip in ad after ad and watch their sales go up.
Those banners you see pulled behind planes along the shoreline in the summertime are another example. The reader doesn't have to do anything; the message literally appears before their eyes. Ads on buses and trains work the same way. The reader sits down and there's the ad. Very slippery. Examples of non-slippery content would be an ad buried in the back pages of a magazine or digital signage content swamped by dozens of other pieces running at the same time.
Is your content slippery? Or do you bury important points in multi-page PowerPoints, 10-minute talking-head videos, and memos crammed with hundreds of words in 8-point type? Assuming you're using a good workplace digital signage platform, you have a great vehicle for being slippery because people naturally walk by it or sit in front of it, that is, it takes very little effort to get people to see the content. Just be sure that, like those plane banners and TV ads, your messaging is concise, clear and well designed.
Content slipperiness comes down to just two factors: make it easy for the reader to find it, and then just as easy to consume.


text: Hey guys, I just installed Xubuntu on a Dell PII laptop. The install went well, but... .. and here's where I expose my Linux ignorance to the world... I've got a PCMCIA 56k modem I wanna use with it, a Zonex ZFM5600CF to be precise. It was listed as linux compatible, but I've no clue how to set it up in this thing. I've got my number and password in to the Network configuration dialog, but I don't even know how to dial this thing to connect. There were only windows drivers on the install disc, do I even need drivers for this modem? I've scouted around the Ubuntu site, but I've got the kids this week and can only study this in a piecemeal manner. Anybody wanna throw a clue my way, and narrow my research a bit? I'll check back, but right now the pressing issue for me is that Flash won't fit into Green Lantern's force shield... (oh noes!) edit: I think I've got the force shield thing figured out, but still having problems with the modem.


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Fashiongrail's Holiday Gift Guide For The Little Fashionista
November 21, 2011 by admin
Filed under Accessories
It's that time of year again and we're here to help! Check out Fashiongrail's Christmas faves for the little fashionista under $50!
Charm bracelets are a classic gift that every little girl loves – $20.09 at Cutey.com
This one is a favortie and something I wish was around when I was little! Fashion Boot Camp 101 workshop will give your budding fashionista all the information they'll need to learn what really goes on behind the fashion world scene – $50 for a three day crash course – Fashionbootcamp101.com
This Leopard Slouch Tunic is perfect for the little fashionista with flair! Pair with jeans, leggings or with bright tights and shorts – $37 at AE.com
Neon and patterns and diamonds, oh my! These DIY nail art pens are easy to use and a perfect stocking stuffer – $12.50 at Fredflare.com
The beauty in the Follow Your Dreams necklace by Dogeared is the simplicity! – $54 at Dogeared.com


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Friday, June 17, 2016
Instructor position - Rockville Senior Center English Program
The Rockville Senior Center English Program in Rockville, Maryland is seeking an enthusiastic instructor for the basic, beginning English class that meets Monday and Wednesday mornings during three, 10-week sessions from September through June.
The Program focuses on English for Everyday Life, using ESOL texts, newspapers and pronunciation resources to teach speaking, listening, reading, and writing skills to learners over age 60 from a variety of cultural, language and educational backgrounds.
This is an opportunity to work with dedicated students who appreciate the safe and supportive environment in which English becomes a valuable tool for making new friends, participating in the community and acclimating to a new culture.
Qualified applicants should have training and experience teaching ESOL and assessing learner progress at the appropriate level, be engaging communicators, and be comfortable working with a team serving a diverse senior population. Some experience with Color Vowel Chart pronunciation is desirable.
Note: this is a paid, contractor – not City of Rockville – position. Please send inquires and letters of interest/resumés by August 4, 2016 to Dunya Hecht, Program Manager:
Rockville Senior Center
1150 Carnation Drive
Rockville MD 20850


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Despite all the uncertainty and rancor surrounding November's U.S. presidential election, one thing is clear: Past trends indicate that the economy could be facing a recession — and could drag the market down with it.
So believes Sven Henrich of NorthmanTrader.com, who crunched the historical figures that suggest, regardless of who becomes the next president, the markets could be in trouble. According to Henrich's analysis, data show that since 1960, 70 percent of new presidents face an economic downturn very early in their first term.
"Historically, that's not good for markets, as they correct between 13 to 40 percent during a recession," Henrich said last week on CNBC's "Futures Now."
Henrich contended that much of the trend could have to do with consumers' uncertainty during transitions between presidents, but he also believes that the coming election differs from those of the past. This, in turn, doesn't bode well for markets, and may heighten the chance of an economic slump.
"In this particular cycle, we're seeing something that we've never seen before in any U.S. election, and that is neither candidate, whether it's Hillary Clinton or Donald Trump, have a majority support within the population," said Henrich. "So no matter who wins, in January Americans are faced with a president that the majority doesn't support."
The latest NBC/Wall Street Journal poll showed that the lead by Democratic presidential candidate Clinton over Republican nominee Trump was narrowing, this ahead of Monday's first presidential debate.
"I have no idea how this is reflected in consumer confidence, but it doesn't seem to suggest that consumers will be very confident with their new president," he added.


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Rhonda Malinsky-Rockwell, M.Ed. CCC-SLP
Business Name: Lumina Speech and Hearing Services
79 Charles St
Uniontown, Pennsylvania15401
Phone Number: (724) 366-1166
Email Address: email@example.com
Website: http://www.LuminaSpeech.com
Describe treatment approach used: - Recommend frequent sessions of shorter duration when possible.
- Begin with small number of words containing relatively successful motor sequences.
- Present random practice, present for imitation, cue , present for imitation, provide feedback.
- When target becomes evident, use of Dynamic Temporal and Tactile Cueing and manipulation cues (verbal cueing and PROMPT) to achieve progressively more accurate approximations of movement sequences.... then present blocked practice to reinforce.
- Provide feedback.
- Start with simple syllable shapes
Describe parent/caregiver involvement: Immediately following assessment, I discuss with parents the report and that treatment plan is based on Summary of Speech Behaviors based on Pre-treatment Assessments and Parent Report. Parents are trained from the beginning for cueing, strategies and rationale and interrelationships of CAS progress with other goals of child. Parents are enlisted to provide school based reading materials/ workbooks, assignments, etc due to the fact that Print–text will be a support for phonological awareness, and sequencing. It is explained that there is a high probability that their child will require explicit intervention to develop phonological awareness abilities for reading and spelling skills
Describe your past and current involvement in the Apraxia community? I have not yet been a member of CASANA or Apraxia-KIDS , but i look forward to attending the next Apraxia Walk and also becoming a contributor to CASANA. I intend to start an Apraxia parent support group in my geographic location at this time.
Do you provide consultation/collaboration with other professionals (for example, attending IEP meetings, co treating, etc.) Yes
Age range treated? birth to 22
Hours of operation: 9:00 A.M. - 7:00 P.M.
Locations where treatment is provided? Office/Clinic, Other
Insurance accepted? Yes


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Ronn Torossian
On the eve of the Independence Day holiday, as millions of American families were planning time together at the beach or backyard barbecues, New Jersey residents were busy canceling plans and trying to find an alternative.
That's because the state's Governor, Chris Christie, ordered the beaches closed. Subsequent to this order, an enterprising photojournalist captured incriminating photos of Christie and his crew sunbathing on an otherwise empty beach. Most people saw this as ultimate nepotism. Meanwhile, the governor's spokesman said his boss didn't get "any sun" because he was "wearing a hat."
The internet exploded. A meme war cut Christie out of a picture and placed him in a series of other photos, some famous and others just funny. The public, accustomed to mocking the New Jersey governor for other reasons, chose to respond to his apparent poor decision by ruthlessly slamming Christie online and in print. But perhaps nothing hit as close to the bone as an editorial in CNN by editor Chris Cillizza.
After detailing the governor's flippant response to reporters asking about the issue, Cillizza explains that those comments were made after Christie told reporters "I didn't get any sun today…" Which, subsequently lead to the "he wore a hat" quip. Christie did earn some points for tweeting that most of the New Jersey coastal beaches were open, however, a point Cillizza concedes, which didn't make it into most coverage of the public relations gaffe. But that admission didn't stop CNN from publishing the idea that Governor Christie just doesn't care anymore.
The opinion piece cites a series of political embarrassments for the governor, including dropping out of the Presidential race, then "traveling around with Trump perhaps in hopes of winding up as the vice-presidential pick or a member of the cabinet … neither happened." Named as head of the Presidential transition team, Christie was later "fired" by Trump, who then appointed VP Pence as his transition head.
The article goes on to point out Christie's approval rating in his state was falling for multiple reasons, some having to do with the campaign, others with his contentious leadership of the state and what some called his heavy-handed style. How bad was it? Well, a Quinnipiac poll cited by CNN put Christie's approval rating at 15 percent, the lowest for any governor of any state ever, according to Cillizza. Adding these facts with a few others, the piece assumes either Christie is actively trying to torpedo his political career, or he has just stopped caring. There is, of course, at least one more option, which has been heard loud and clear from Christie supporters in and out of the press. To wit, this is all much ado about nothing, that the guy got some sun and laughed it off … so what? Aren't there worse things in the world?
So, has Christie really stopped caring? And, if so, what will that charge do to his political aspirations beyond the Governor's office? Will it be a benefit or a detriment to his plans to secure a spot in a presumptive second Trump administration? Or is this, yet again, more red meat for partisans who love to hate New Jersey's brash leader?
Ronn Torossian is CEO of 5WPR.


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CPI Aerostructures Announces Second Quarter 2014 Results
August 7, 2014
CPI Aerostructures, Inc. ("CPI Aero®") (NYSE American: CVU) today announced financial results for 2014 second quarter and six months ended June 30, 2014.
Summary Highlights
Second quarter and six month 2014 results included a one-time, non-cash charge of approximately $47 million related to revised estimates of a significantly shorter lived and lower production quantity A-10 WRP. The net effect of the charge is a reversal in the quarter of a portion of the revenue recognized in prior periods dating back to the inception of the program in 2008.
The long-term future of the A-10 has been uncertain since March 2014 when the US Department of Defense released its 2015 Budget Request that called for the retirement of the entire A-10 fleet. More recent events have led us to conclude that our A-10 WRP will not continue to the full 242 aircraft as anticipated at the start of the program. For example, the 2015 Department of Defense Appropriations Act passed by the United States House of Representatives on June 20, 2014 provides no funding for A-10 operations in Government fiscal year 2015 that commences October 1, 2014. Further, this bill rescinds funding from the 2014 Defense Budget that was to have been used for the procurement of additional wings for the A-10. The Company has no information to support a different conclusion.
When adjustments are required for the estimated total revenue on a contract, these changes are recognized with an inception-to-date effect in the current period. When estimates of total costs to be incurred exceed estimates of total revenue to be earned, a provision for the entire loss on the contract is recorded in the period in which the loss is determined. The cumulative adjustment to revenue, from the inception of the program in 2008 through June 30, 2014, for this change in estimate is $44.7 million, all of which is adjusted in the three month period ended June 30, 2014.
There has been considerable public discourse on the future of the A-10 aircraft that has caused uncertainty as to the A-10 program's continuation. The environment has impacted CPI Aero's ability to achieve any of the normal program cost reductions at suppliers. In addition to the $44.7 million adjustment to revenue, we have recorded a $2.6 million adjustment to cost of sales as a result of the change in estimate on the A-10 WRP.
Since 2008, the Company has received firm orders for assemblies to produce 173 wings. The non-cash charge taken this quarter assumes that the contract will conclude no later than September 2015, the end of the 2015 Government fiscal year, and at less than the current 173 order quantity. This non-cash charge is included in both the cost of sales and revenue for the second quarter and six month periods ended June 30, 2014.
Douglas J. McCrosson, CPI Aero's President & CEO, stated, "Adjusted results for the second quarter of 2014 were in line with our expectations and we are on track to achieve our guidance for 2014, excluding the nonrecurring A-10 WRP charge. Adjusted revenue for the three month and six month periods ended June 30, 2014 was approximately $21.0 million and $42.9 million respectively, compared to approximately $21.1 million and $41.0 million respectively, for the same periods in 2013. Adjusted earnings per share for the three month and six month periods ending June 30, 2014 were $0.20 per share and $0.41 per share, respectively, compared to $0.21 per share and $0.41 per share for the same periods in 2013. In our 2015 forecast we discounted the contribution of the A-10 WRP to revenue and net income. The expected growth in revenue and net income for 2015 will be largely driven by growth in our commercial product lines. As such, our 2015 guidance is unchanged and reaffirmed."
Mr. McCrosson continued, "The decision to take this non-cash charge now was a difficult one, but given the current set of facts, it is the correct one. It is our belief that we will end production on the A-10 WRP at between 55% and 60% of the original planned quantity. As a result, the investments we made in the past to improve efficiency and lower supply chain costs are no longer able to realize the expected return. Our negotiating leverage with our suppliers was impacted by the constant media reports predicting the aircraft's retirement. Additionally, future cost savings initiatives are no longer worth pursuing on a program with limited life and instead will now be deployed in support of our longer lived commercial programs. For example, we had planned to invest in automation for assembling parts with significantly reduced manual labor and were developing alternative supply chain strategies to drive down procurement costs. Finally, this program has incurred significant tooling and non-recurring engineering and other labor costs associated with achieving the required technical specifications and production rate at the targeted labor cost. These tooling and other nonrecurring costs will now be amortized over a significantly shorter program life."
Mr. McCrosson added, "Due to the loss incurred in the quarter ended June 30, 2014, we were not in compliance with net income financial covenant contained in our Credit Agreement with Santander Bank and Valley National Bank. On August 6, 2014, the Company entered in an amendment and waiver to the Credit Agreement which, among other things, provided for a waiver of the covenant. Going forward, we believe that CPI Aero has an opportunity to lower its estimated loss on the A-10 WRP, either by equitable adjustment to our contract with Boeing or by a Government termination for convenience and we will be exploring all avenues to reduce our loss. The GAAP loss recorded in the second quarter of 2014 will allow us to claim a 2015 tax refund of over $9 million from prior years' tax payments and is expected to yield a more than $5 million tax credit that will offset our anticipated tax liability in future years. In total, this adjustment we are making to the A-10 WRP will improve 2015 cash flow by more than $14 million."
Guidance Discussion
For Full Year 2014
Adjusted revenue for the six month period ended June 30, 2014 was $42.9 million, compared to $41.0 million for the first half of 2013.
Commercial programs generated 14% higher revenue in the first six months of 2014 compared to the same period in the prior year. For the first half of 2014, revenue generated from commercial programs was approximately $15 million, or 35% of total adjusted revenue. This compares to approximately $13.1 million, or 32% of revenue for the first six months of 2013.
For the six month period ended June 30, 2014, we shipped products valued at approximately $38.2 million compared to $34.4 million of shipments in the first half of 2013, an increase of 11%.
For Full Year 2015
Production for existing programs and initial production for several new programs, including the recent $9 million Embraer order to manufacture engine inlet assemblies for the Phenom 300 business jet, are expected to ramp up in the coming months. Thus the 2015 guidance we provided during the 1Q14 earnings release remains unchanged. For 2015 we expect:
Backlog and Outlook
Total backlog at June 30, 2014 was $391 million, as compared to $431.4 million at December 31, 2013, with 43% of total backlog for commercial aerospace contracts. At June 30, 2014, funded backlog was $96.4 million compared to $110.4 at December 31, 2013. The value of our long-term contracts that has not been converted to funded orders we refer to as unfunded backlog. The value of the unfunded backlog at June 30, 2014 was $294.3 million, with 49% related to our long-term commercial aerospace programs. This figure does not include the recently announced $9 million amendment to our contract with Embraer for the Phenom 300 engine inlets that occurred in July 2014.
Mr. McCrosson commented, "As of June 30, 2014, we received approximately $19.2 million of new contract awards, $18.7 million of which were commercial. This is 45% greater than the total of $13.2 million of new contract awards, of all types, in the same period of 2013. It is our goal to finish 2014 with record funded backlog of greater than $110.4 million, the value at the end of 2013, which would give us a "book-to-bill" ratio greater than 1. Currently, we are in negotiations with Northrop Grumman to provide Outer Wing Panel Kits (OWP) to support both their recently announced $3.6 billion multi-year contract with the US Navy for 25 E-2D Advanced Hawkeyes and the long-term US Navy contract for wings for the C-2A Greyhound aircraft. CPI Aero has been under contract with Northrop Grumman since 2008 to provide OWP kits for both the E-2D and C-2A aircraft. We remain confident that we will have a very good second half of the year for new contracts."
He added, "We continue to seek opportunities in the global defense markets, particularly within the more complex aerospace pod systems for existing and potential new customers. For example, the DB-110 Reconnaissance pod program we perform for UTC Aerospace Systems has been exceptionally well received by our customer and we believe will serve as a great platform to grow our business with both UTC Aerospace and other customers in the Intelligence, Surveillance and Reconnaissance segment of the defense market. Similarly we are well established in the defense helicopter market with our relationships with both Sikorsky and Bell and we look to effectively compete on the newest vertical lift programs of strategic priority to the US Government such as the Future Vertical Lift program, the Combat Rescue Helicopter recently awarded to Sikorsky, and to grow our existing content on the CH-53K Super Stallion. Approximately 40% of our bid pipeline includes high value proposals in the commercial aerospace markets, including the business jet and large commercial airliner markets. We continue to improve our chances to succeed in this competitive market by making the needed investments in new automated manufacturing technologies and production floor software that will increase output, improve quality, and lower production costs."
Mr. McCrosson concluded, "Looking past today's non-cash charge related to the change in estimate to the A-10 WRP, we see a business that is as strong as it ever has been. We have a large funded backlog that is on track to reach an all-time high. Our strategy to diversify into commercial aerospace via the business jet sector is paying off now as the demand for business aircraft is showing every sign of recovery. We continue to earn a stellar reputation with customers for being a highly skilled manufacturer capable of producing even the most complex aerospace systems and structures. We are performing on many long-term contracts which will continue to generate significant revenues for years to come and we are bidding on larger and more complex programs than ever before that will enable our continued growth in 2015 and beyond."
Conference Call
CPI Aero's President and CEO, Douglas J. McCrosson, and CFO, Vincent Palazzolo, will host a conference call today, Thursday, August 7, 2014 at 10:00 am ET to discuss these results as well as recent corporate developments. After opening remarks, there will be a question and answer period. Interested parties may participate in the call by dialing (201) 493-6739. Please call in 10 minutes before the scheduled time and ask for the CPI Aero call. The conference call will also be broadcast live over the Internet. To listen to the live call, please go to www.cpiaero.com and click on the "Investor Relations" section, then click on "Event Calendar". Please access the website 15 minutes prior to the call to download and install any necessary audio software. The conference call will be archived and can be accessed for approximately 90 days. We suggest listeners use Microsoft Explorer as their browser.
About CPI Aero
CPI Aero is a U.S. manufacturer of structural assemblies for fixed wing aircraft, helicopters and airborne Intelligence Surveillance and Reconnaissance (ISR) pod systems in both the commercial aerospace and national security markets. Within the global aerostructure supply chain, CPI Aero is either a Tier 1 supplier to aircraft original equipment manufacturers or a Tier 2 subcontractor to major Tier 1 manufacturers. CPI also is a prime contractor to the U.S. Department of Defense, primarily the Air Force. In conjunction with its assembly operations, CPI Aero provides engineering, program management, supply chain management, and MRO services. Among the key national security programs that CPI Aero supplies are the E-2D Advanced Hawkeye surveillance aircraft, the UH-60 BLACK HAWK® helicopter, the F-16 Falcon fighter, the T-38C Talon trainer, the MH-53/CH-53 variant helicopters, the MH-60S mine countermeasure helicopter, the AH-1Z ZULU attack helicopter, the DB-110 reconnaissance pod, the ALMDS mine detecting pod, and the A-10 Thunderbolt attack jet. In the commercial aviation market CPI Aero manufactures products for the Gulfstream G650 ultra-large cabin business jet, the HondaJet advanced light jet, the Embraer Phenom 300 business jet, the new Cessna Citation X+, and the S-92® helicopter. CPI Aero is included in the Russell Microcap® Index.
The above statements include forward looking statements that involve risks and uncertainties, which are described from time to time in CPI Aero's SEC reports, including CPI Aero's Form 10-K for the year ended December 31, 2013 and Form 10-Q for the quarter ended March 31, 2014.
CPI Aero® is a registered trademark of CPI Aerostructures, Inc.
CPI Aerostructures, Inc.
Adjusted Earnings (arrived at by eliminating the affect of the change in estimate on the Company's A-10 Program with Boeing) is not derived in accordance with generally accepted accounting principles ("GAAP"). Adjusted earnings is a key metric CPI Aero is using in evaluating its 2014 financial performance. Adjusted earnings is considered a non-GAAP financial measure as defined by Regulation G promulgated by the SEC under the Securities Act of 1933, as amended. CPI Aero considers Adjusted Earnings important to evaluate its 2014 financial performance on a consistent basis across various periods. Due to the significance of the non-cash and non-recurring change in estimate in the quarter ended June 30, 2014, Adjusted Earnings enables the Company's Board of Directors and management to monitor and evaluate the business on a consistent basis. CPI Aero will use Adjusted Earnings as a measure, among others, to analyze and evaluate financial and strategic planning decisions regarding future operating decisions and investments. The presentation of Adjusted Earnings should not be construed as an inference that CPI Aero's future results will be unaffected by unusual or non-recurring items or by non-cash items, such as changes in estimates. Adjusted Earnings should be considered in addition to, rather than as a substitute for, pre-tax income, net income and cash flows from operating activities.
CPI Aerostructures, Inc.
Vincent Palazzolo
Chief Financial Officer
CPI Aero
(631) 586-5200
Jody Burfening/Sanjay M. Hurry
800 Third Avenue
New York, NY 10022
(212) 838-3777
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Who is Father Augustus Tolton?
"A colored child born April 1, 1854, son of Peter Tolton and Martha Chisley, property of Stephen Elliott."
That's all his baptismal record says. Born a slave to Peter Paul and Martha Tolton, of Brush Creek, Missouri, he grew up to become the first African American Catholic priest.
Ten years later, his father had gone to fight for the Union Army and was presumed dead in the Civil War. His heroic mother then risked her life to escape slavery. With her three young children, Martha Tolton crossed the Mississippi in a boat with one oar. After dodging Confederate bullets, she and her children then ran all the way to the town of Quincy, in the free state of Illinois. There they made a home, and Augustus Tolton grew in the Catholic Faith and in the conviction that God was calling him to be a priest.
Constantly the victim of racial prejudice, he was cast out of the local Catholic school and eventually, he went on to study for the priesthood in Rome. He was ordained on April 24, 1886 in the Basilica of Saint John Lateran, with the intention of heading for Africa as a missionary. However, God had other plans and Fr. Tolton was sent back into the hostile environment of his own hometown of Quincy, Illinois.
His sermons and presence there were inspiring and charismatic. White and black alike flocked to his church. This aroused the jealousy of the other Catholic priests in the area. Protestant black ministers were also envious and felt he was stealing people away from their congregations.
Finally, Fr. Tolton was transferred to Chicago where he set about establishing a parish in that city. First, his tiny congregation met in the basement of "Old Saint Mary's" Church. Then he began the work of building Saint Monica Church, named for the African mother of Saint Augustine. Fr. Tolton's reputation for holiness grew. The phenomenon of a black Catholic priest, who was a terrific preacher, placed a demand on him to travel the country. This he did tirelessly, evangelizing and raising money for his struggling congregation.
Returning from a priests' retreat, Fr. Tolton collapsed from heat exhaustion and was taken to Mercy Hospital. Tragically, he died there on July 9, 1897, at the age of 43.
Fr. Augustus Tolton's life here on earth was one of hidden holiness. His cause for canonization has been presented by Cardinal Francis George to the Vatican and is moving forward quickly. Bearing the insults of racial prejudice, he suffered with Christ, reminding us of these words of Psalm 118:
"The stone that the builders rejected has become the cornerstone."
Important Dates
Born: April 1, 1854, to Martha and Peter Tolton, in Brush Creek, MO
Escaped to freedom in Quincy, Illinois: about 1862
Civil War: 1861-1865
Confirmation & First Communion: 1870 (age 16) at St. Peter Church, Quincy, IL
Enrolled in St. Francis College, now Quincy University: 1878
Departure for seminary in Rome: February 15, 1880
Ordination: April 24, 1886, at St. John Lateran Basilica, Rome
First Mass: April 25, 1886 at St. Peter's Basilica, Rome
First Mass in Quincy, IL: July 18, 1886 at St. Boniface Church
Began Ministry in Chicago: December 19, 1889
Dedication of St. Monica Church in Chicago: January 14, 1894
Death: July 9, 1897 at Mercy Hospital in Chicago from heat stroke, age 43, interred July 13 in the cemetery in Quincy, Springfield Diocese, per his request
Cause for Sainthood: Opened February 24, 2011, under Francis Cardinal George of Chicago
Declared Servant of God: April 17, 2015


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When negotiating a contract the parties commonly think about what should happen in the event that the other party breaches a term of the contract. They may also wish to stipulate what should happen upon the occurrence of a certain event (which may not technically constitute a "breach" of the contract). The other party might […]
- When are agreed damages clauses in contracts unenforceable penalty clauses rather than enforceable liquidated damages clauses?
- $45,000 damages for republication of defamatory statement by third party: Milne v Ell [2017] NSWSC 555 (8 May 2017)
- Franchisors and holding companies beware: Fair Work Amendment (Protecting Vulnerable Workers) Bill 2017
- Protecting your brand & trade mark registration
- Does your business need a privacy policy?


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The Secret Life of Walter Mitty bares little resemblance to it's 1947 counterpart staring Danny Kaye, and that is a good thing. I vaguely remember watching the 1947 adaptation - probably as a Saturday or Sunday afternoon television movie as a child. I probably enjoyed it too as I watched a lot of Danny Kaye's movies in my youth. They were always funny and entertaining.
Ben Stiller's new adaptation of the story, both of which are inspired by the short story by James Thurber, not only updates the story for today's world but also turns it into much more of a funny, feel-good, inspirational journey. Stiller and the movie's writer, Steve Conrad, have elevated the idea to a whole other level.
2013's Walter Mitty movie is a commentary on life, that can be taken as just an entertaining, cinematic journey or it can move you to thinking about doing more to experience and live a real life yourself. Step away from the computer, stop experiencing life through a camera phone and start being in and creating real life memories.
I've never been a huge fan of Ben Stiller movies and I don't really know why. They can be a bit hit or miss with the humor, sometimes going into completely silly premises that cross some imaginary line in my brain that says "I can't believe you're watching this?". Of the Ben Stiller movies I've seen I can't say any were all bad and I think his humor is growing on me.
However, it was the trailer to Walter Mitty that really hooked me in. The epic leap Walter does from the railway station platform into the building window moments before the apartment explodes in a ball of fire, racing several levels down to the door, revealing Walter's exit, having saved the life of a dog owned by a very pretty woman... and then back to reality, where Walter zones back in having missed his train.
If you're not a Ben Stiller fan then this is the Ben Stiller movie for you. If you are, you don't need me to say go and see it.
I totally bought into Ben as Walter Mitty, from the very beginning, where he's struggling with the idea of whether or not to send a wink on an internet dating site. For anyone who lives in their head, that kind of thing can be a big deal. It may be a slow start to the film but that really sets up how uneventful Walter's life has been to this point.
Walter's journey throughout the film seems a little bit contrived as he attempts to track down a missing photograph negative, needed for the cover of the last edition of Life Magazine. However it's easy to forgive that because it's just great to see Walter having all these experiences that highlight how exhilarating real life can be.
I really don't need to talk up this movie at all. All you need to know is in the trailer. It's got a great supporting cast and Adam Scott's beard should be up for a best supporting actor nomination (I've never seen a manicured beard that screams 'BEARD!!' at you before).
Worth seeing in the cinema for both the special effects and the cinematography on location. This is a grown up Ben Stiller film, with some silly and childish moments that are well within the context of the overall story.
I enjoyed it a lot.
South Australian Artist, Writer, Video Producer and Animator, David Arandle working under the pseudonym 'The Extraordinary Tourist' or 'TET' for short, blogs about Art, Life, Social Issues, humor, Internet/Technology, Movies, Entertainment, World Issues, Business, People/Places and more.
The Secret Life of Walter Mitty - Movie Review
Posted Tuesday, December 31, 2013
In Posts About: Movies and Entertainment
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The team of the restaurant Las Aguas in the Bahía del Duque designs creates the official launch menu for the Spanish Royals.
Wednesday, April 26 2017.- The team that leads the restaurant Las Aguas in the Hotel Bahía del Duque, company owned by Compañía de las Islas Occidentales (CIO), was chosen to prepare and serve the official lunch menu for the Kings of Spain during their visit yesterday to the headquarters of the Presidency of The Canary Islands headquarters in Tenerife.
The team from Las Aguas, made up of 5 wait staff and 6 chefs, led by Canarian head chef Braulio Simancas, elaborated a complete menu that journeys through the most important ingredients, elaborations and wines of The Canary Islands, offering the diners, a culinary representation of each corner of the archipelago.
The menu began with a savoury starter of Shrimp from Alto with avocado and Masca onions; followed by a first course of spring watercress cream soup from La Gomera with vine beans, Canarian pork and cheese from La Gomera.
Wreck fish was the chosen product to star in the main course and was elaborated by the team of Las Aguas using a squid broth, Canarian potatoes and roasted onions.
Following the main course, the royals tasted a platter of cheeses from La Palma, Flor de Guía in Gran Canaria and Fuerteventura, which preceded the dessert, consisting of spongy cured goat cheese with guava and butter biscuits.
In the selection of wines, a Canarian representation was also chosen, starting with a 2015 Altos de Trevejos, sparkling rose D.O. Abona; 2015 white Paisajes de la Isla DOP Islas Canarias; 2015 Can Tinto D.O. Valle de la Orotava and a white Bermejo sweet malvasía, DO Lanzarote.
"As an anecdote from today we have to mention the request by Queen Letizia to try the traditional Canarian dish "Tollos", which was not planned, but that my team and I gladly prepared to satisfy her wishes" states Brualio Simancas, chef of the Restaurant Las Aguas of the Hotel Bahía del Duque.


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Ntb-National Tire & Battery is located at the address 8420 Lyra Dr in Columbus, Ohio 43240. Ntb-National Tire & Battery specializes in Autos, Trucks, Classic.
Ntb-National Tire & Battery has an annual sales volume of 2M – 4,999,999. .For more information contact Mike Doan, Manager or go to www.tirekingdom.com
Ntb-National Tire & Battery provides Rotations, Auto Repairs, Engine Work to it's...
National tire & battery is your complete automotive care experts featuring auto performance and light truck tires brake services alignments oil change tune-ups and a great selection of wheels!
NTB National Tire and Battery located at 8420 Lyra Drive in Columbus, OH services vehicles for Retail Tire. Call (614) 847-2145 to book an appointment or to hear more about the services of NTB National Tire and Battery.
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Purchase a set of tires, they had a great price and courteous people that help me. It was very fast, even with an alignment.
I was having an epically bad Monday and of course to top it off my car got a flat tire. NTB Polaris just turned my whole night around. The amazing service I got will definitely mean I will recommend this place to all my friends.
Automobile - Repairs & Services
Automobile - Repairs & Services
Ntb National Tire & Battery offers a number of services such as brake fluid exchange, oil change, coolant exchange, wheel alignment, tire rotation, battery inspection and more. The mechanics at Ntb National Tire & Battery are well trained and have a vast experience when it comes to car fixing. The tires available at Ntb National Tire & Battery are from leading brands like Goodyear, Hankook,...


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We couldn't be more excited to announce that we will be at Wilderness Festival! Our little bio can be found here :)
Come on down and grab a Vurger between the 3rd and 6th of August, we can't wait to see you there with these three.... which one will you have?
Read more about the festival here :- https://www.wildernessfestival.com/


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"You better start swimming or you'll sink like a stone. For the times they are a-changing."
2016 has brought forth the best tangible evidence in many years that Bob Dylan's lyrics from 1964 are as true now as they were 5 decades ago. Every election year brings, or at least promises, an inevitable shift, but it felt like 2016 was the year that was determined to truly show change. Either way the coin flipped.
Politically, in businesses, and industry sector specific changes, the world will look differently in 2017. At the end of each year, we naturally look towards transformation and evolution. Personally, and also in massive scale through business transformation. It only seems fitting that at the end of each year, we take stock both things accomplished and the fails, and then set our sights on what's next.
I can say with confidence that "change" and "transformation" were the 2 key words of which organizations requested most frequently to see in 2016, when considering prospective executives that would lead them through a shifting 2017. Hands-down. And for good reason. Smart businesses are looking to stay ahead of the curve and pushing towards versus resisting change. They have seen it on the horizon and know that the ways in which they plan now to embrace and lead this change, is critical... Industries are rapidly evolving themselves to meet the way products and services are being demanded by businesses and consumers alike, 2016 being tangible evidence of change in so many facets and the Health Care and Energy sectors standing center stage as 2 of the best industry examples. Technology is merging itself into more staunch, traditional roles and industries and the structured ways of past business success is cyclical and making a comeback to humble and merge with a rapidly evolving workforce. In 2017, the trend of change will continue, in greater force and maybe even lean more drastically towards becoming key words in business "revolutions".
But going back to it, the term "transformation" in it of itself is extremely subjective. What that means to one, is completely different to 2 others (and those 3 people with separate definitions, could be the combined hiring committee for your next prospective executive to lead this change). To define this and work towards the common goal of positive change in your business, a few key questions need to be asked:
What does transformation look like in your industry, as a whole?
Is the forecast in 2017 of growth, rebuilding, downsizing? What will it mean not to just change your business landscape to meet the industry's trend, but to be ahead of it?
What does transformation look like for your business (or business unit, product) specifically?
Is your business looking to make bold, public moves toward change or is the theme subtler, and under the radar? Think about the people employed today... will change affect the cultural employee dynamic as it existed in 2016? Are you combining products and business units to speak to an unanswered market demand?
How does this translate to tangible attributes of a leader?
By truly knowing the goals of the first 2 questions, this helps bring to life what has just been the theory of a new executive towards real, tangible attributes one will seek in prospective candidates which will speak best to the common goals. A growth focused, change-driven, and risk taking executive may be the perfect face of a business or product to the external market, with a strong presence and likeability. However, this may not align with the end goals of the business unit's operational complexity and vice versa. Understanding the critical components this executive will drive versus the superficial aspects will build the profile of your leader.
Answer these questions first, and you can take the next steps towards finding the right leader to elevate your organization in leading the pack and towards successful evolution, or even revolution in 2017.... For the Times They Are A-Changin'.
image credit mlive.com


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The Chinese Vice Premier, Wang Yang told the Sri Lankan foreign minister, Tilak Marapana who is currently visiting Beijing that the government expected the two countries to work more closely, reports Xinhua.
"China highly values its relations with Sri Lanka, and regards the country as an important cooperation partner in the Belt and Road Initiative, which aims to build a trade and infrastructure network connecting Asia with Europe and Africa along the ancient Silk Road trade routes and beyond," Mr Yang was reported by the Chinese state owned news site as saying.
"China expects to cement solidarity and cooperation with developing countries including Sri Lanka," he added.
Mr Marapana said, "Sri Lanka considers China a close friend and partner, and hopes to participate in the 21st Century Maritime Silk Road, and boost cooperation in ports, infrastructure and other areas."


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Class Schedule
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8am (B) Cami
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Yoga Nidra
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Takes the flow deeper, emphasizing core strength, fluid movement, creativity and a sense of play. This class is designed to leave you feeling balanced – strengthened, stretched, challenged and nurtured. Classes incorporate daily themes and meditations.
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Culture is the crux of the brand. An individual can try to locate Indian Oil's brand culture. Brand Identities are supposed to last. Brand Identity is intended for internal consumption. As a consequence, developing a brand identity is among the most significant steps a business may take to guarantee a consistent, enduring brand. Thus, when thinking about a brand name, consider the expert advice from image consultants and branding professionals who will assist you to really think of a decent brand identity. It is also helpful to set a brand identity that could be recognized at first glance.
Things You Should Know About Corporate Brand Identity
The more complicated The repeat orders, the bigger the variety of happy clients, Camper states. Understanding the customer's needs is the very first step to creating a good brand identity. Should itn't then this might be a great place to begin in defining or even sense checking your branding strategy. So it's a very good concept to consciously understand who that you want to be and the values you would like to communicate to the marketplace. Before defining your brand, you should have a thorough understanding of your brans purpose and set on the market. It produces a customer experience. In the industrial LPG segment the general Brand Experience has been excellent.
Even though a company may have several buyer personas, this is the very best kind of buyer. The companies which offer you a brand identity must also be certain that they're bringing the most recent goods in the digital showroom they've provided you. In this instance the business won't have adequate cash flow to fulfill financial obligations. All successful businesses evolve. Thus the business in case wants a different treatment concerning branding. It promises quality brand and company vision through a good brand symbol. Smart companies know about this and take time to consider their brand identity and who they would like to be.
To genuinely understand the way your branding is being interpreted, you must get to understand facts from the outside. Business branding isn't limited to a particular mark or name. Whether it's selling a cheap or a costly item branding is essential for all and should be presented in the very best manner. In the same way, there exist various media that can be effectively employed for advertising. Billboard advertising is quite popular. Billboard advertising Advertising uses several tools and methods to draw the customers outdoors. Radio advertising is among the oldest kinds of advertising.
A brand is among the most valuable assets of a company, and it has to be cautiously crafted to ensure it correctly and authentically represents the small business. Before you try to define your brand, you should do a little bit of exploration. The brand has in order to identify it. Amazing brands can easily be recognizable and to do this, it ought to be crafted carefully to make sure the brand properly and accurately represents the small business. Amazing brands like GoPro are simple to recognize. It's also essential for them to understand the merchandise in offering.
One that your customers are going to have major part in shaping. The customers have a tendency to perceive the issues are directly about the fuel. They were unable to recall the brand in spite of aiding. The client should be known completely about the benefits of branding.


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Lecture: 'From Einstein's Theory to Gravity's Chirp'
October 10, 2017
4:00 pm-5:00 pm
Hasbrouck Hall
Room: 20
UMass Amherst Campus
Published in 1915, Albert Einstein's theory of General Relativity appeared to imply the existence of gravitational waves: an entirely new form of energy and radiation. However, physical reality of these implied waves was doubted by many, including Einstein himself, for well over half a century.
A 1974 discovery made in the UMass Department of Physics and Astronomy, together with more detailed follow-up measurements extending over many years, has laid all such doubts to rest. Moreover, it provided persuasive justification for funding what became a successful billion-dollar experiment to detect gravitational waves directly.
The century-long effort to better understand some of Nature's most fundamental laws makes a fascinating and entertaining story. It is a superb example of the scientific method at work -- warts, blind alleys, and all.
This lecture is intended for a general audience: no pre-requisites required, beyond an interest in Nature's truths.
Joseph H. Taylor, Jr., is the James S. McDonnell Distinguished University Professor of Physics, emeritus, at Princeton University. B.A. 1963, Haverford College; Ph.D. 1968, Harvard University. Since weeks after their discovery in 1968, Taylor has studied the dense, rapidly spinning, neutron-star remnants of supernovae known as pulsars. Together with his students and colleagues, he has discovered hundreds of these objects, including a number that move in orbits around other stars. Studies of these binary pulsars have provided unique astrophysical clues regarding the origin and evolution of neutron stars, as well as the first conclusive evidence of the existence of gravitational radiation, as predicted by Einstein's general theory of relativity. Taylor was a research fellow at Harvard University (1968-1969) and taught at the University of Massachusetts, Amherst (1969-1980) before joining the faculty at Princeton in 1980. At Princeton, Taylor also served as dean of the faculty from 1997 to 2003. Taylor is co-author of the book Pulsars (1977). He won a MacArthur Fellowship in 1981. Other awards include the Wolf Prize (1992), the Einstein Prize (1993), and the Nobel Prize (1993). Taylor is a member of the American Philosophical Society, the National Academy of Sciences, and the American Academy of Arts and Sciences. He is also well known by his amateur radio call sign, K1JT.
Event CategoryLecture/Talk Physics


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Friday, October 14, 2011
Death Answers to God, and He Said No
|Like what you see?
10 comments:
Amazing....more evidence of how much he loves us and hears us when we cry out to him.ReplyDelete
I think he was granted a miracle others would love to have! So happy for him. sandieReplyDelete
Looking back they see the hand of God in it all; going through it I am sure through their trust they still had concerns, worry, touch of doubt, etc, but amazing how he did make a full recovery and years later be there to dance at his daughter's wedding! I eagerly await the next parts of the story!ReplyDelete
- AnonymousOctober 14, 2011 at 5:11 PM
I so needed to hear this. Wonderful timing to remind me of what I believe.ReplyDelete
Thanks, Margaret.
Amazing. Totally amazing.ReplyDelete
- FirenzeOctober 14, 2011 at 9:49 PM
Looking forward to the next blog. BTW, in 1988 the hospital was called Humana I believe.ReplyDelete
My memory is so bad, I would have never remembered it was ever named Humana! I think I remember that now, and "think" is the key word.ReplyDelete
The picture is just beautiful! God is faithful isn't He?! I lurve this!ReplyDelete
I'm glad I read this. yes. tissue was required so far.ReplyDelete
So I'm glad I know how the story ends since I see the picture! What a beautiful miracle.ReplyDelete
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NYU Dominican Club Hosts Gentrification Panel
By Miranda Levingston, News Editor
October 17, 2017
Filed under News, University News
The Kimmel Center hosted a panel on gentrification and what students can do to stop it.
181 Mercer Street Construction Begins
By Sherah Ndjongo, Contributing Writer
March 8, 2017
Filed under 2031 Expansion, News, Uncategorized, University News
Construction for NYU's 181 Mercer Street project has begun. Some students are looking forward to seeing the finished product, while others question the necessity of a new NYU building.
Despite Grievances, NYU Incomparable
February 27, 2017
Filed under Opinion, Top Stories
Although NYU offers its students an abundance of opportunities and resources, the university still has a lot of progress to make before it can reflect the values held by its student body and faculty.
NYU's Role in Gentrification
February 6, 2017
Filed under Opinion
While it is tempting to take a hard line for or against gentrification, it is important to acknowledge both the progressive changes and harmful effects in order to strike a balance that helps everyone.
Cities on Both Coasts Mishandle Homelessness
By Emily Fong, Deputy Opinion Editor
March 7, 2016
Filed under Opinion
As tensions and tempers flare between the encroaching walls of gentrification and those who find themselves forced out of their old homes, the parallels between San Francisco's issues with homelessness and New York's are clear.
The Perils of Technological Gentrification
By Shiva Darshan, Staff Writer
February 23, 2016
Filed under Opinion
Irresponsible expansion of the tech community has the potential to make the city unlivable for thousands, particularly if both the natives and the transplants establish lives entirely disconnected from one another.
'In Jackson Heights' director Frederick Wiseman talks gentrification
By Tony Schwab, Staff Writer
November 3, 2015
Frederick Wiseman's "In Jackson Heights" explores the intense cultural diversity of the Queens neighborhood. WSN spoke with Wiseman about gentrification robbing neighborhoods of local personality and his documentary style.
Anti-gentrification efforts need to stop targeting independent businesses
By Adnan Zarif, Contributing Writer
October 7, 2015
Filed under Opinion
Local stores and cafes in London's trendy East End are the wrong outlets for protest ire.
NYU must grow responsibly in NYC
By Abraham Gross, Contributing writer
September 22, 2015
Filed under Opinion
NYU cannot claim to be a responsible member of Greenwich Village when it does not act as a responsible steward to the area's history.
Harry's Take: Closing bookstores detract from city's vitality
April 21, 2014
Filed under Exclude From Homepage List, Opinion
Cutthroat competition and surging rent prices have forced many of New York's booksellers to abandon shop. For local bookstores, the price of rent has reached a level that has proven unsustainable. Despite residents who choose to buy their latest novels from local bookstores instead of online behemot...
Vittorio's Razor: Conversation on gentrification should fairly consider both sides
April 3, 2014
Filed under Exclude From Homepage List, Opinion
Use of the word gentrification has become taboo in New York City. A more nuanced analysis of the effects of gentrification, however, reveals a less critical judgment of its merits. Gentrification, like all agents of change, does much good, most of which counteracts the harm done to a neighborhood's or...


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