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Spark someone's attention by sending this absolutely radiant bouquet. Full of flowers and fiery beauty, it makes a beautiful gift for any occasion.
Features dark orange roses and orange asiatic lilies in a charming glass vase. It's fiery and it's fabulous!Approximately 15" W x 18" H
Orientation: One-Sided
The Bouquet you selected can be upgraded by our expert florist.
You May Also Like


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Well, i dont know if i am missing something, and if i am, tell me, but the only way i find i can get to forums to browse is to just thing of something to search for and link to it from there. why not just put a link on the main page to the forums.
Results 1 to 5 of 5
Thread: Forums

subset: commoncrawl


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You would discover Sierra Helada Natural Park with beautiful views from the cliffs, the Isla Mitjana just infront of them, and the Peñón de Ifach in Calpe in the horizon, hiddern Corners like Punta de Cavall, a very easy route for all the family with spectacular seafront views in the Nature, small beaches along the way with just a few visitors, even reaching the Lighthouse in Albir, where you can find Bombarda Tower, built in the 17th century to protect the village from pirates.
All these itineraries can be easily followed on our TAO Bikes. And now, during February child accesories are for FREE!!!
More info here


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Hopi House, Grand Canyon, Arizona. 12941
about 1908
Publisher Detroit Publishing Company, Publisher Fred Harvey Trading Company (American, 1897 - 1968)
Horizontal: 8.9 x 14 cm (3 1/2 x 5 1/2 in.)
Accession Number
Medium or Technique
Offset photomechanical print on card stock
Not On View
Front: Fred Harvey.
Back: divided. Mint.
Fred Harvey
"Phostint" Card Made only by Detroit Publishing Co.
Trade Mark - Reg. U.S. Pat. Off.
Between 1950 and 2011, acquired by Leonard A. Lauder, New York, from various postcard dealers in the United States, Canada and Europe; 2013, gift of Leonard A. Lauder to the MFA. (Accession Date: December 18, 2013)
Credit Line
Leonard A. Lauder Postcard Archive—Gift of Leonard A. Lauder


text: Toggle Clamp Upgrade (ep66) FerryQuickBuild, Shop Projects, Simple Builds 16 Comments Share this:FacebookGoogleTwitterTumblrPinterestReddit Toggle clamps are essential for woodworking jigs and fixtures. A lot of times they come with a rather small clamping foot. If you are using multiple clamps and/or securing the workpiece against a fixed fence, you may have no problem. It still bugged me that they seemed to let the wood move unless you had them set to an extremely high clamping pressure. Not to mention with a smaller surface area you are prone to denting your workpiece. I can dent projects on my own and don't need toggle clamps to help me do that. If you want to know how to remove dings and dents, I have a solution for that as well. It was mainly the narrow rubber foot on the clamp that flexed too much and acted as a pivot point that really got me thinking. I have used elevator bolts in the past to remedy similar problems, but wanted the slight cushion rubber would give me. That is when I looked at rubber feet for amplifiers and road cases. Many of them have an integrated metal washer in which the rubber is moulded around. They worked perfectly especially for my spline and tenon jig! If you want to buy these rubber feet, you can click here. Likewise, if you are in need of any toggle clamps, these are the ones I used for this project. The small, flexible rubber tip, that let wood sometimes move had to go. These are the feet I was going to use for the new clamp pad. They have a built in metal washer which is perfect to ensure I'll have a good connection with the hardware. You can purchase the feet here. At the time I got them, they were $4 for a pack of 8. They measure roughly 1.5″ in diameter and 3/4″ tall. Insert a 2″ x 1/4-20 machine screw into the rubber foot and add a fender washer. Thread on and tighten down a 1/4-20 nylon lock nut. This is what the clamp foot should look like at this point. After removing the old clamp pad (foot), I add a regular 1/4-20 nut for adjustment of different wood thicknesses. With the adjustment nut in place. Using the factory alignment washers, install and secure the new foot in place. The toggle clamp before and after. The newly modified toggle clamp can be mounted to a piece of plywood to cut smaller pieces on the table saw sled. If you are interested in my table saw sled with built in aluminum miter tracks, click here. The main reason I wanted to modify the toggle clamp, is to use it in a mitered spline/tenon jig I am making. It works like a charm! Much more clamping surface area and a much better hold on the workpiece. Can't ask for more than that! Well now I just need to modify a couple more clamps. Let me know in the comments below what you think and if this is something you are going to try. If you do, I'd love to hear what you think. Thanks for checking it out! Select list(s): Notify me weekly Notify me of every update Email * Share this:FacebookGoogleTwitterTumblrPinterestReddit 16 Responses Tony May 13, 2016 I like the idea. Rockler and Peachtree both sell larger pads that swivel. https://www.amazon.com/Large-Toggle-Clamp-Foot-Long/dp/B001ENSLW6/ref=sr_1_2?ie=UTF8&qid=1463158797&sr=8-2&keywords=toggle+clamp+foot Reply Nick May 13, 2016 yup – seen those before – haven't tried them yet, but I'm sure they do the trick Reply Steve Kinnaird May 13, 2016 Thanks Nick! I will definitely be putting a few of these together. Reply Nick May 13, 2016 awesome – let me know how you like them! Reply Keith E. Cooper May 17, 2016 Simple, yet handy! Thanks so much for posting! Reply Nick May 17, 2016 not a problem – work amazingly well for a quick cheap upgrade Reply daddywoofdawg May 18, 2016 What size are your toggle clamps,i have bought a few online and they are really small,I know they make larger ones but can't tell the size. Reply Nick May 18, 2016 did you check the link in the article? those are the ones I used – http://amzn.to/1sjvPXn – they are the regular size Reply Steve May 24, 2016 This is an awesome idea. Thanks for posting. Reply Nick May 24, 2016 no problem – thanks for checking it out Steve! Reply Cannon December 22, 2016 Thank you for the great info! I've ordered 4 of these clamps, and the replacement feet based off of your recommendation. Reply Nick December 22, 2016 nice – how are they working out for you so far? Reply Mike March 11, 2017 Hey Nick, Great stuff I tried 3 times to join your newsletter and never got anything, and yes, I checked the spam box. Here's my email ***********.net. TIA Mike Reply Nick March 12, 2017 I just confirmed you manually – you should get the next one which will probably be within a week – if you don't, let me know – thanks! Reply Matt Kessler January 26, 2018 This is great! I have been looking for longer bolts for my Toggle clamps for certain jigs, and this solves it! I did also find some already made on Rockler that I ordered, but in the future I will be using your idea. Great site and great videos Nick! Thanks Reply Nick January 26, 2018 thank you – glad you could get some ideas! Reply Leave a Reply to Nick Cancel reply


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Feeling rotten? This page can help you determine what you have, and what to do about it.
Symptoms of colds, flu, pneumonia and meningitis
Symptoms can be similar, and mistaking one for the other could mean an extended illness and serious complications. So how do you know what you have?
Colds are inconvenient but usually not serious and can be treated at home. Symptoms may last 4-14 days and include:
- Runny nose and/or sneezing
- Coughing
- Sore throat
- Head and body aches
- Low fever (less than 101° F or 38.3° C)
- Congestion of the ears, nose, throat and head
Flu typically hits in Michigan December-March. Acute symptoms last 3-4 days, and cough may linger for 3 weeks. Gastrointestinal symptoms are rare. Complications are uncommon in young, otherwise healthy adults. Symptoms include:
- Rapid onset of symptoms
- High fever (greater than 101° F or 38.3° C)
- Severe body aches and/or headache
- Dry cough
- Extreme fatigue
- Chills
Pneumonia can be serious and even fatal. See a clinician if you experience symptoms:
- High fever (greater than 101° F or 38.3° C)
- Cough that produces thick, brown or bloody phlegm
- Chills
- Chest pain while breathing
- Wheezing or shortness of breath
Meningitis requires immediate medical care. Early diagnosis and treatment is critical. Meningitis can be caused by viruses or bacteria, and bacterial meningitis can be fatal if untreated. If you experience meningitis symptoms, consult your clinician or go to an emergency room immediately. Symptoms include:
- High fever (greater than 101° F or 38.3° C)
- Severe, sudden headache accompanied by any of the following:
- Mental changes (e.g. agitation or confusion)
- Neck or back stiffness
- Rash on any part of the body (commonly the armpits, groin, ankles)
- Extreme sensitivity to light
When to seek medical care:
For sore throat:
Self-care is okay if you:
- Have a scratchy throat,
- Can swallow liquids
- Have minor swelling of neck glands.
Get medical care if you have:
- Difficulty swallowing liquids
- White or yellow spots in throat
- Increased pain after 3 days
For fever:
Self-care is okay for fever less than 101° F (38.3° C).
Get medical care if you have:
- Fever greater than 101° F (38.3° C) for more than 3 days
- Fever that fluctuates above 101° F (38.3° C) several times a day
- Shaking chills
For cough:
Self-care is okay for dry cough
Get medical care if you have
- Persistent cough
- Chest pain
- Wheezing
- Shortness of breath
- Foul smelling, brown or bloody phlegm
For runny nose and sneezing:
Self-care is okay for:
- Relatively clear drainage
- Mild sinus and/or facial discomfort
Get medical care if you have:
- Foul smelling, brown or bloody drainage
- Severe sinus and/or facial discomfort
For headache:
Self-care is okay for
- Mild pain
- Pain that improves with non-prescription pain reliever (e.g. acetaminophen, ibuprofen)
GET MEDICAL CARE IMMEDIATELY if you have headache with:
- Blurred vision
- Dizziness
- Nausea or vomiting
- Neck or back stiffness
- Mental changes (e.g. agitation or confusion)
- Severe headache with fever greater than 101° F (38.3° C) and rash anywhere on the body
For body ache:
Self-care is okay if you have general aches.
Get medical care if you have persistent pain in your abdomen.
For fatigue:
Self-care is okay if you have general aches.
Get medical care if you have excessive fatigue.
For earache:
Self-care is okay if you have stuffy or clogged ears.
Get medical care if you have pain in or discharge from ears.
Tips for treating yourself:
Listen to your body. If you feel well enough to exercise, it may help to counter fatigue that often accompanies a cold or flu. But don't overdo it - cut back on the intensity and duration of your usual workout until fatigue abates, then build up again slowly. Intense activity may increase discomfort and lower your resistance to additional infection.
Drink plenty of fluids. Drink as much water and juice as possible - preferably two quarts per day - to help counter the dehydration that causes much of the discomfort associated with fever. Fluids are also important for loosening and removing secretions and stuffiness from the body. Fluids may also help soothe a sore throat. Alcohol and caffeine tends to dehydrate, so try to avoid it.
Refrain from smoking. Smoking makes it difficult for your body to eliminate mucous from the lungs and may predispose you to bronchitis or pneumonia. This would be a good time to consider quitting! See Tobacco Cessation Help. If you choose not to quit, try not to smoke during the respiratory illness.
To relieve a sore throat, drink plenty of fluids.Gargle with warm water (you can add salt) to help reduce any inflammation. Keep your throat moist by using a vaporizer or sucking on throat lozenges or ice cubes made from fruit juice. See also Sore Throat? Here's What to Do.
For congestion, try sleeping on your back with your head raised on two or three pillows. You may find additional relief with oral and/or nasal decongestants.
For sore nose and chapped lips, apply petroleum jelly or emollient lotion. A 0.5-1% hydrocortisone cream applied three times a day may also provide relief to a red, irritated nose.
Tips for academic success when you are sick:
See Tips for Academic Success While You are Sick.
Non-prescription medications for colds and flu:
The UHS Pharmacy sells a variety of medications.
Some overall tips:
- It's usually best to take a single medicine targeted for a particular symptom rather than an all-in-one preparation.
- Generic versions are as effective and usually cheaper than brand-name versions.
- Use caution when combining medications. If you're taking more than one medication, consult your pharmacist or clinician.
- Be sure to read warning labels, follow instructions and use medications only when necessary.
Analgesics reduce body aches, headaches and fever:
- Acetaminophen (e.g. Tylenol, Panadol) is a painkiller and fever reducer. Doesn't irritate the stomach. Safe for people who are allergic to aspirin.
- Aspirin is a painkiller, fever reducer and anti-inflammatory with relatively few side effects. May irritate stomach, so take with food. Not recommended if under age 19 due to association with Reye's syndrome.
- Ibuprofen (e.g. Advil, Nuprin) is a painkiller, fever reducer and anti-inflammatory. May irritate stomach, so take with food.
- Ketoprofen (e.g. Orudis, Actron) is a painkiller, fever reducer and anti-inflammatory. Similar effect as ibuprofen. May irritate stomach, so take with food.
- Naproxen sodium (e.g. Aleve) is a painkiller, fever reducer and anti-inflammatory. Pain relief lasts 8-12 hours, about twice as long as other painkillers. May irritate stomach, so take with food.
Antihistamines (e.g Benadryl, Chlortrimeton, Claritin, Allegra, Xyzal and Zyrtec) dry mucous membranes and make breathing easier:
- May cause dryness of the nose and mouth.
- Often cause drowsiness, so should not be used while driving or operating machinery.
Decongestants (e.g. Sudafed, Afrin Nasal Spray) shrink swollen nasal membranes and make breathing easier:
- May act as a stimulant and increase heart rate in some people
- Most effective when taken orally but may also be taken as nose drops or sprays.
- Should be used with caution by people with high blood pressure.
- Nasal drops/sprays are not advised for more than 3 days because they may actually increase congestion (called "rebound effect").
Cough expectorants (e.g. Robitussin) may loosen secretions and make coughs more productive.
Cough suppressants (e.g. Diphenhydramine syrup, Robitussin DM, Delsym 12-hour) reduce sensitivity to the cough reflex so you cough less. Good for coughs that prevent sleeping.
Lozenges and throat sprays (e.g. Chloraseptic, Cepastat, Halls) temporarily relieve the pain of a sore throat. Dissolve lozenges slowly in the mouth. Continuous use may cause nausea.
Prescriptions for flu:
Antiviral drugs, available by prescription, may decrease the severity and duration of illness if taken within 48 hours of onset of symptoms.
Antiviral drugs may also be used during a local outbreak to prevent influenza in people who are at high risk of complications and who have not been previously vaccinated.
Antibiotics are not effective against the viruses that cause colds and flu. Viruses multiply within the body's cells where antibiotics generally cannot reach. And unnecessary antibiotic use disrupts the body's natural balance of organisms and increases resistance. For more information, see Antibiotics: Less is More.
Alternative treatments for colds and flu:
Alternative treatments include chicken soup, echinacea, zinc lozenges and vitamin C. These treatments may reduce duration and severity of cold symptoms, but their effects are not proven and they are not regulated by the US Food and Drug Administration, so purity and dosage of products is not ensured.
Note the following cautions:
- If you use zinc lozenges, make sure to reduce intake down to Recommended Daily Allowance (15 mg for men and 12 mg for women) after your cold. Over the long term, too much zinc (more than 50-100 mg per day) may weaken your immune system, interfere with absorption of other minerals and lower your HDL ("good") cholesterol.
- If you take vitamin C supplements, be aware that more than 500 mg per day may lead to cramps, diarrhea and kidney stones. Chewable vitamin C also erodes tooth enamel.
Please consult your clinician or the following resources for more information about alternative treatments:
- Office of Dietary Supplements, National Institutes of Health
- National Center for Complementary and Alternative Medicine, National Institutes of Health
Stop the spread of germs that make you and others sick!
- Get vaccinated. See Flu and Vaccination and Meningitis and Vaccination.
- Cover your nose and mouth with a tissue every time you cough or sneeze. Throw the used tissue in a wastebasket. If you don't have a tissue, sneeze or cough into your sleeve.
- Clean your hands with soap and water or an alcohol-based hand cleaner.
- Avoid touching your eyes, nose or mouth.
- Do not share eating utensils, drinking glasses, towels or other personal items.
- Stay home when you are sick.
- Avoid close contact with people who are sick, if possible.
For more information:
To use UHS, see Schedule an Appointment -- Appointments are required for most medical services, although options are available for urgent problems
Nurse Advice by Phone is available day and night, which may save a trip to UHS, the ER or an urgent care facility.


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You are here: Root > Programming Languages > Common Lisp > ANSI StandardGo directly to another tag
Conduit packages
Conduits are a generalization of packages. They allow the definition of packages that extend other packages in some way, such as having some symbols from another package. This is part of the Lisp hack...
Hierarchical packages
An implementation of hierarchical packages, i.e. packages with a hierarchically structured namespace. It is based on the Allegro CL hierarchical packages by Franz, Inc.. This is part of the Lisp hacks...
Read-time packages
A library that makes it possible to read an entire Lisp form in the context of a given package by switching packages at read time. This is part of the Lisp hacks collection by Tim Bradshaw.


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The following recall has been announced:
DETAILS: Falls Creek Kids infant and toddler denim jeans imported by Meijer Distribution Inc. of Grand Rapids, Mich.; sold exclusively at Meijer and HEB stores nationwide from June through November 2012. Falls Creek Kids infant and toddler, boys and girls denim jeans were sold in sizes 12M-5T. "Falls Creek Kids" is printed on a tag sewn on the inside back of the waistband. The jeans are denim; some have a pink star or heart graphic design stitched on the outside front and back of the jeans. The jeans also were sold with cargo-style pockets. There is label on the inside of the jeans near the front-left pocket that includes the date and location of production. The jeans were manufactured in China.
WHY: The snap on the front of the jeans may come loose and separate from the fabric, posing a choking hazard to young children.
INCIDENTS: None reported.
HOW MANY: About 140,500.
FOR MORE: Contact Meijer at 800-927-8699, or visit the firm's website at http://www.meijer.com .


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Gear Guide
Company: M-Edge
Website: www.MEdgeStore.com
Model: Slip Sleeve
Price: TBD
Compatible: iPad (2010)
M-Edge Slip Sleeve for iPad
By Charles Starrett
Senior Editor, iLounge
Published: Friday, March 12, 2010
Category: Cases - iPad, iPad (2010),
M-Edge, makers of cases and protective solutions for e-readers like the Amazon Kindle and Barnes & Noble nook, has announced a new line of cases for the Apple iPad. The Slip Sleeve is a horizontal canvas and leather case featuring a top-opening flap cover with an elastic strap closure and microfiber interior. M-Edge's line of new cases for the Apple iPad is listed as coming soon; pricing has yet to be announced.
Editors' Note: iLounge only reviews products in "final" form, but many companies now change their offerings - sometimes several times - after our reviews have been published. This iLounge article provides more information on this practice, known as revving.


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- المواصفاتتحويل المواصفات للمتريحجم عامود الدوران4 "X-Horiz TVL من الجدول63 "Y فير TVL من رئيس50 "القدرة15 hpRPM1600 rpmالجدول-W49 "الجدول-L55 "المغزل تفكره.30 "
- عن الشركة
the oldest existing machine tool manufacturer in Europe, and with over 180 employees, one of the largest employers in the region. True to the motto "Using technique with tradition and technology of the future", we use our know how from more than 160 years to solve the tasks of tomorrow. The UnionChemnitz brand stands for innovation, flexibility, quality and performance. With the un-compromising application of these values, we became one of the market leaders in the pro-duction of horizontal boring mills. Our machines are suitable for machining work pieces up to 40 m (131 feet) long, up to 10 m (33 feet) high and up to 250 tons. A wide network of agencies and service organizations throughout the world provides support for our customers and contributes to expanding and strengthening our market position. Our modular machines, made in Germany, surpass expectations with maximum power and high precision, and with an unbeatable price-performance ratio. This has enabled us to create a wide range of products which are applicable for a variety of technological requirements.
خدمة وإصلاح محلات
- خدمة وإصلاح محلات2Cahmac Machinery
2730 Brighton Road
Oakville, Ontario L6H-5T4
كنداProductivity Inc - Machine Tool Supplier
15150 25th Ave. N.
Plymouth, Minnesota 55447
الولايات المتحدة الامريكية


text:
Back to Main
Faculty Detail
Campus Address
MCLM 684 Zip 0005
Other websites
Medical School
University of Pecs, Medical School
University of Pecs, Medical School and Haynal Imre University of Health Sciences Budapest, Hungary
Pathologist, Histopathologist
Pathology and Histopathology
Faculty Appointment(s)
Appointment Type
Cell, Developmntl, & Integrative Biology
Cell, Developmntl, & Integrative Biology
Associate Professor
Comprehensive Diabetes Center
Comprehensive Diabetes Center
Associate Professor
Cystic Fibrosis Research Center
Cystic Fibrosis Research Center
Associate Professor
GL Ctr for Craniofacial, Oral, & Dental Disorders
GL Ctr for Craniofacial, Oral, & Dental Disorders
Associate Professor
Graduate Biomedical Sciences Affiliations
Cell, Molecular, & Developmental Biology
Genetics, Genomics and Bioinformatics
Medical Scientist Training Program
Pathobiology and Molecular Medicine
Biographical Sketch
Dr Bebok completed her medical degree and a residency program in Pathology and Histopathology at the University Medical School of Pecs, Hungary. As a student and later as faculty member, she worked under the guidance of Dr. Peter Nemeth at the Department of Immunology at the University Medical School of Pecs, Hungary. In 1993, she started a postdoctoral fellowship at the Department of Physiology, University of Alabama at Birmingham under the mentorship of Dr. Eric Sorscher. As junior faculty at the Department of Medicine at UAB, and associate scientist of the Cystic Fibrosis Research Center, she worked on the cellular and molecular mechanisms underlying cystic fibrosis. Dr. Bebok's research concentrates on cellular mechanisms that govern membrane protein biogenesis and how they contribute to the development of human disorders. She joined the Department of Cell Biology in 2002.
Research/Clinical Interest
Membrane protein expression regulation by the unfolded protein response (UPR) and mutations. The consequences of synonymous mutations on protein structure and function.
Our studies concentrate on 1) cellular mechanisms that reduce endoplasmic reticulum (ER) protein load during the unfolded protein response (UPR) to alleviate ER stress and 2) how mutations and single nucleotide polymorphism affect mRNA structure and co-translational protein folding. ER stress and activation of the UPR contribute to the pathogenesis of a wide range of human disorders including chronic obstructive pulmonary diseases (COPD), diabetes mellitus and neurodegenation. Thus, understanding the molecular pathways of the UPR will provide important clues for the development of molecular therapies. We are interested in genes that are repressed at the transcriptional and post-transcriptional levels by the UPR. We have shown that transcriptional repression, reduced translation and enhanced endoplasmic reticulum associated degradation (ERAD) contribute to decreased cystic fibrosis transmembrane conductance regulator (CFTR) function during ER stress. Reduced CFTR function and markers of UPR activity have been observed in patients with chronic bronchitis and COPD. To understand post-transcriptional gene repression during ER stress, we identified UPR induced miRNAs. We have shown that the UPR activated transcription factor XBP1, induces the expression of miR-346, defining a novel function for XBP1, and identified the targets of miR-346 as genes that regulate immune responses and ER peptide influx. We selected additional micro-RNAs that are regulated during the UPR and studies are in progress to define their ER stress associated regulators and understand their biological significance by characterizing their targets. Our second project investigates how mutations and synonymous single nucleotide polymorphisms (SNPs) affect mRNA structure and consequently, co-translational protein folding. We have demonstrated that one SNP in the CFTR gene alters mRNA structure and affects translation. We are investigating the functional consequences of this SNP and the role of other SNPs in CFTR folding. I have a strong background in pathology, immunology and for the past 15 years I studied membrane protein biogenesis in epithelial cells.
Selected Publications
Rab, A., R. Bartoszewski, A. Jurkuvenaite, J. Wakefield, J. F. Collawn, and Z. Bebok. 2007. Endoplasmic reticulum stress and the unfolded protein response regulate genomic cystic fibrosis transmembrane conductance regulator expression. Am J Physiol Cell Physiol 292:C756.
Bartoszewski, R., Rab, A., Twitty, G., Stevenson, L., Fortenberry, J., Piotrowski, A., Dumanski, J., Bebok Zs. The mechanism of CFTR transcriptional repression during the unfolded protein response. J. Biol.Chem. 283:12154-65, 2008. PMID:18319256
Bartoszewski, R, Rab A, Jurkuvenaite A, Mazur M, Collawn JF, and Bebok Z. Activation of the unfolded protein response by ΔF508 CFTR. Am J Respir Cell Mol Biol. 39: 448-57, 2008. PMID: 18458236
Bartoszewski, R., Rab, A., Fu L., Collawn JF. and Bebok, Z. Methods to Study Membrane Protein Expression Regulation by the Unfolded Protein Response. Methods in Enzymology, UPR and Cellular Stress. Methods Enzymol. 2011;491:3-24. PMID: 21329791
Bartoszewski, R., Brewer, J. W., Rab, A., Crossman, D. K., Bartoszewska, S., Kapoor, N., Fuller, C., Collawn, J. F., Bebok, Z. The unfolded protein response (UPR)-activated transcription factor XBP1 induces micro-RNA-346 expression that Targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes. J. Biol. Chem. 2011.DOI: 10.1074/jbc.M111.304956 22002058
The silent codon change I507-ATC->ATT contributes to the severity of the ΔF508 CFTR channel dysfunction.
Influenza virus M2 targets cystic fibrosis transmembrane conductance regulator for lysosomal degradation during viral infection.
Decoding mechanisms by which silent codon changes influence protein biogenesis and function.
Bartoszewski, R., Jablonsky, ZM., Stevenson, L., Dai, Q., Kappes, J., Collawn, J.F., and Bebok, Z. A synonymous single nucleotide polymorphism in ΔF508 CFTR alters the secondary structure of the mRNA and the expression of the mutant protein. J. Biol. Chem., 285:37, 28741-8, 2010. PMID: 2937902.
membrane proteins, ER stress, UPR, SNP, mutation, CFTR, micro-RNA
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text:
Indiana man faces charges in Maine after chase
Jul. 22, 2013
WINDHAM, Maine (AP) — An Indiana man who was allegedly drunk when he led Maine police on a high-speed chase that ended when he crashed his minivan into the rear of another vehicle is headed to court.
Jeremy Moon of Fortville, Ind., is expected to make his first court appearance Monday on charges including driving to endanger and operating under the influence.
Moon was arrested Saturday night after a chase that started in Raymond and ended a few miles away in Windham.
Police say they tried to pull over the 33-year-old Moon, but he took off and eventually crashed into an SUV, injuring two girls inside, ages 12 and 14. The girls were taken to a hospital.
Moon was held over the weekend and it's not clear if he has hired a lawyer.


text:
Market Keeps Truckin' Ahead of Economy
What a long, strange trip it's been.
Since stocks hit their bear-market low in March 2009, they have rallied nearly 145%. Yet the U.S. economy is scuffling along by comparison. That dichotomy, and fears that loose monetary policy is inflating financial assets, looms over Federal Reserve Chairman Ben Bernanke's testimony next week to Congress's Joint Economic Committee.


text:
Evidence stacks up that monolith at Gardom's Edge is astronomically aligned
Researchers at the Nottingham Trent University have gathered new evidence that a 4000-year-old monolith was aligned to be an astronomical marker. The 2.2 metre high monument, located in the Peak District National Park, has a striking, right-angled triangular shape that slants up towards geographic south. The orientation and inclination of the slope is aligned to the altitude of the Sun at mid-summer. The researchers believe that the monolith was set in place to give symbolic meaning to the location through the changing seasonal illuminations. Dr Daniel Brown will present the findings on Tuesday 27th March at the National Astronomy Meeting in Manchester.
The rare example of a monolith is located at Gardom's Edge, a striking millstone grit ridge less than an hour's drive from Manchester. The researchers have carried out a microtopography survey of the surface surrounding the monolith. Their findings indicate the presence of packing stones around the base of the monolith, evidence that it was placed carefully in position. They have also carried out 3-D modelling of illumination of the stone through the seasons, adapting for changes in the Earth's tilt to the ecliptic plane over four millennia.
The landscape surrounding the stone harbours many ancient monuments such as Bronze Age roundhouses, a late Neolithic enclosure, and other traces of a long lasting human occupation. The researchers believe that the stone is also late Neolithic, set in place around 2000 BC.
"Given the sensitivity of the site, we can't probe under the surface of the soil. However, through our survey, we have found a higher density of packing stones on one side, supporting the case that the stone has been orientated intentionally," said Dr Brown.
The 3-D modelling shows that during the winter half-year, the slanted side of the stone would remain in permanent shadow; during most of the summer half-year it would only be illuminated during the morning and afternoon; close to midsummer it would be illuminated all day. The researchers are currently backing up the modelling work by gathering contemporary photographic evidence of the stone.
"The stone would have been an ideal marker for a social arena for seasonal gatherings," said Dr Brown. "It's not a sundial in the sense that people would have used it to determine an exact time. We think that it was set in position to give a symbolic meaning to its location, a bit like the way that some religious buildings are aligned in a specific direction for symbolic reasons."
The researchers hope that the new evidence will support the case for a wider archaeological survey of the site.
"The use of shadow casting in monuments of this period is quite rare in the British Isles," said Dr Brown. "But there are some examples including New Grange, Ireland, and some Clava cairns in the north-east of Scotland that have been proposed to include the intentional use of shadows. Both are associated to burial sites using the symbolism of a cyclic light and shadow display to represent eternity. Given the proximity of the Neolithic enclosure and possible ritual importance of this site, the Gardom's Edge monolith could be another such example."
Dr. Daniel Brown
Physics and Mathematical Sciences
School of Science & Technology
Nottingham Trent University
Tel: 0115 848 3518
On Tuesday 27 and Wednesday 28 March, Dr Brown can be contacted through the NAM 2012 Press Office
NAM 2012 Press Office (0900 – 1730 GMT, 27-29 April; 0900 – 1630 GMT 30 April)
Room 3.214
University Place building
University of Manchester
Manchester UK
Tel: +44 (0)161 306 7313
Dr Robert Massey
Royal Astronomical Society
Mob: +44 (0)794 124 8035
Anita Heward
Royal Astronomical Society
Mob: +44 (0)7756 034 243
Dr Klaus Jaeger
Images can be found at: http://danielbrown.pbworks.com/w/page/27407022/Links
1. Gardom Monolith: Image from the team's photographic survey (Oct 2011), taken looking directly to the west. Note the triangular shape and flat north facing side. Credit: D Brown/Nottingham Trent University
2. Standing Stone Model: Illustration of the stone looking to the south-east in a moment in time (Summer half of the year 2000 BC) just after the north-facing side sees Sunlight for the first time after a brief spell of darkness during midday. The periods of darkness at midday will slowly decrease until around Midsummer when the north-facing side is illuminated during midday as well. Credit: D Brown/Nottingham Trent University
3. Monolith Profiles: This sketch gives an overview of the different profiles of the standing stone as they appear when viewing either to the north, east, south or west. Credit: D Brown/Nottingham Trent University
4. Gardom Monolith: View towards the south. This image shows how the north-facing side remains in shadow in the winter half year even during midday. Credit: D Brown/Nottingham Trent University
5. Microtopology: This contour map indicates the possible location of packing stones and their increase density towards the NW base of the Monolith. Credit: D Brown/Nottingham Trent University
The overall project website for the 3-D survey:
Bringing together more than 900 astronomers and space scientists, the National Astronomy Meeting (NAM 2012) will take place from 27-30 March 2012 in the University Place conference centre at the University of Manchester in the UK. The conference is a joint meeting of the Royal Astronomical Society (RAS) and the German Astronomische Gesellschaft (AG) and is held in conjunction with the UK Solar Physics (UKSP: www.uksolphys.org) and Magnetosphere Ionosphere Solar Terrestrial (MIST: www.mist.ac.uk) meetings. NAM 2012 is principally sponsored by the RAS, AG, STFC and the University of Manchester.
The Royal Astronomical Society
The Royal Astronomical Society (RAS: www.ras.org.uk), founded in 1820, encourages and promotes the study of astronomy, solar-system science, geophysics and closely related branches of science. The RAS organises scientific meetings, publishes international research and review journals, recognizes outstanding achievements by the award of medals and prizes, maintains an extensive library, supports education through grants and outreach activities and represents UK astronomy nationally and internationally. Its more than 3500 members (Fellows), a third based overseas, include scientific researchers in universities, observatories and laboratories as well as historians of astronomy and others.
The Astronomische Gesellschaft (AG)
The Astronomische Gesellschaft (AG: www.astronomische-gesellschaft.de), founded in 1863, is a modern astronomical society with more than 800 members dedicated to the advancement of astronomy and astrophysics and the networking between astronomers. It represents German astronomers, organises scientific meetings, publishes journals, offers grants, recognises outstanding work through awards and places a high priority on the support of talented young scientists, public outreach and astronomy education in schools.
The Science and Technology Facilities Council
The Science and Technology Facilities Council (STFC: www.stfc.ac.uk) is keeping the UK at the forefront of international science and tackling some of the most significant challenges facing society such as meeting our future energy needs, monitoring and understanding climate change, and global security. The Council has a broad science portfolio and works with the academic and industrial communities to share its expertise in materials science, space and ground-based astronomy technologies, laser science, microelectronics, wafer scale manufacturing, particle and nuclear physics, alternative energy production, radio communications and radar. It enables UK researchers to access leading international science facilities for example in the area of astronomy, the European Southern Observatory.
Jodrell Bank Centre for Astrophysics
The Jodrell Bank Centre for Astrophysics (JBCA: www.jb.man.ac.uk/) is part of the School of Physics & Astronomy at the University of Manchester. JBCA is split over two main sites: the Alan Turing Building in Manchester and the Jodrell Bank Observatory in Cheshire. At Jodrell Bank Observatory, the new Jodrell Bank Discovery Centre is a key focus for our work in public engagement and education. Jodrell Bank is a world leader in radio astronomy-related research and technology development with a research programme extending across much of modern astrophysics. The group operates the e-MERLIN national radio astronomy facility and the iconic Lovell Telescope, hosts the UK ALMA Regional Centre Node and is home to the international office of the SKA Organisation. Funded by the University, the Science & Technology Facilities Council and the European Commission, it is one of the UK's largest astrophysics research groups.


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The hotel's rooms Pullman Marseille Provence Airport
The hotel offers four levels of comfort: Classic, Superior, Deluxe and Suite. In the Deluxe Room, enjoy the zen-like decor with a king-size bed and sofa. The "Savane" Suite offers 807 sq. ft. (75 m²) for you to enjoy a luxury stay.
Equipment and servicesCollapse All
Some of the facilities listed below may not be available for every room.
At Pullman hotels we take connectivity seriously. It's not merely about plugging and playing. It's about getting and staying online with the utmost security.
- WIFI in your room
- High-definition televisionwith a wide variety of channels
- Internet access via Fiber Optics
A Pullman platform bed is more than just a bed. It's an environment for sleep, work and just lounging around. With memory foam pillows.
- Welcome tray
- Safe deposit box
- Free in-room mineral water
- Optimal accoustic isolation
- Blackout curtains
- Mini bar with free soft drinks
- Air conditionning with individual remote
- Minibar
- Nespresso experience offered
- Room service: From full meals to light refreshments, from local delicacies to international classics, our room service menu can suit any schedule or mood.
- During the week: 24 Hours
- At weekends: 24 Hours
The fragrance evokes a sense of peace, rich in lavender scents and mint freshness. With a head of zesty citrus on a floral rose body and a musky base, it has a hint of tobacco.
- Bathtub
- Hair dryer in bathroom
- Universal shaving plug
- Make-up/magnifying mirror


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Are you an Arenac County painter, photographer, pencil and pen artist, sculptor, writer, actor or actress, musician or filmmaker?
If so, are you looking for a way to promote your art and network with other artists?
"The Arenac County Independent's" Web site, arenacindependent.com, is in the process of launching a local artists page. This page will allow you to display and promote your art on the Independent's site, which is visited over 3,000 times a month, and still growing! Be a part of the growth, while also gaining credentials and exposure in the art realm.
To be a part of the local artists page, simply pick up a form to submit samples of your work as well as a short bio of yourself. Forms are currently available at the Independent office, 1010 West Cedar Street in Standish (formerly Dr. Ronald Schwab's veterinary clinic); the Northeast Michigan Arts Council, on the corner of US-23 and Grove Road in Standish; and from school art teachers.
A launch date has not been established for the artists' page, but the number of forms completed and submitted will serve as a guide as to how big the launch will be and how much space will be dedicated to local art.
As the artists' page grows, local artists may also be highlighted monthly, or more frequently, in editions of "The Arenac County Independent."
For more information, call 989-846-4531.
Please review our community guidelines before posting
Please keep comments on topic and appropriate for all ages. Remember that people of all ages read our website. Those that are not appropriate will be removed. Please read our full community guidelines before posting.


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Wadleigh State BeachApril 19. 2011 9:48PM
Wadleigh State Park offers swimming on beautiful Kezar Lake. Tall pine trees shade the picnic sites located adjacent to the beach, making it an ideal location for families and group outings. Amenities in the park include a bathhouse, picnic tables, and playing fields.
Location: Route 114, Sutton
Phone: 603-927-4724
Activities: Swimming, picnicking, fishing, biking, canoeing, kayaking, winter recreation
Amenities: Bathhouse, picnic tables, playing fields
Operation Schedule:
This park is unstaffed and open year-round for recreation.
Acreage: 43 acres
Waterfront: Kezar Lake


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Paulsen Rules Out Run for US Senate or Minnesota Governor
MINNEAPOLIS (AP) - Republican U.S. Rep. Erik Paulsen has ruled out a run for the U.S. Senate or for governor of Minnesota, saying he plans to seek a fourth term in the House instead.
Paulsen, whose district includes the western suburbs of Minneapolis, said in a statement Monday that he believes the House is where he can be most effective and best represent the people of his district and the state.
Paulsen says he finds the partisanship in Washington to be deeply frustrating, but he wants to continue working to solve problems.
No prominent Republicans have yet emerged to challenge Democratic U.S. Sen. Al Franken in 2014.
The most prominent GOP contenders hoping to challenge Gov. Mark Dayton so far are Orono businessman Scott Honor and Hennepin County Commissioner Jeff Johnson.


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Sometimes there is some sort of sea fog coming iin. It is quite rare because normally it is to windy for the fog to stay but about twice a year you get this really dense fog which makes the orange lights of Menai bridge illuminate it in a different way.
Wales (Cymru in the Welsh language) is part of the United Kingdom of Great Britain and Northern Ireland. The major cities are Cardiff, Swansea, Newport and Bangor. The city of St. Davids is the smallest city in the UK with a population around 2000. Wales itself has a population of around 3 million. The Welsh language is spoken by around 20% of the population.


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Alabama Rallies To Defeat LSU, 21-17
Alabama junior quarterback AJ McCarron
Quarterback AJ McCarron connected with T.J. Yeldon on a 28-yard touchdown pass with :51 remaining, to lift the top-ranked Alabama Crimson Tide to a 21-17 come-from-behind victory over the fifth-ranked LSU Tigers, on Saturday night, at Tiger Stadium in Baton Rouge, Louisiana.
The win increased Alabama's win streak to 13 games, dating back to the 2011 season, and ended LSU 22-game home field win streak, which was the longest in the country.
The Tigers took a 3-0 lead at the 6:11 mark of the first quarter, courtesy of a 38-yard field goal by Drew Alleman, before the crimson Tide scored 14 unanswered points in the second quarter, on a 7-yard run by Eddie Lacy at the 8:17 mark, and a 9-yard run by McCarron right before the end of the half, at the :11 mark.
LSU scored the only points of the third quarter, when Jeremy Hill capped off a 13-play, 56 yard drive, with a 1-run run, cutting the Alabama lead to 14-10 at the 3:35 mark of the third quarter.
The Tigers later grabbed the lead at the 12:58 mark of the final quarter when quarterback Zach Mettenberger hit Jarvis Landry on a 14-yard pass, making it 17-14, LSU.
LSU looked as though they were going to put the game away late in the gamey, driving into Alabama territory and forcing the Crimson Tide to call their remaining timeouts. But the drive stalled, and after a missed field goal, Alabama took over, and so did McCarron.
The junior completed three straight passes, accounting for 44 yards, to get the football to the LSU 28-yard line.
After an incomplete pass, McCarron teamed up with Yeldon for the game winner with only :51 left.
LSU out-gained Alabama, in terms of total yardage, 435-331, and held possession of the football for 39:15 in the game.
Mettenberger played the best game of his career for the Tigers, completing 24-of-35 passes, for 298 yards, and a touchdown, while Hill rushed for 107 yards, and a touchdown, on 29 carries.
For Alabama, McCarron threw for 165 yards, including a touchdown, while Eddie Lacy and Yeldon combined for 159 yards on 22 carries.
With the win, Alabama improved to 9-0 overall, and 6-0 in SEC play, while LSU fell to 7-2 overall, and 3-2 in league play.
View the game box score.


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The boycotts were threatened. The irate tweets were posted.
NHL fans were fed up with labour strife updates and they weren't coming back to the sport they loved once the lockout was lifted.
Except that they did. In most homes and arenas, they came in record numbers, unable to stay away for that first faceoff.
The fans partied in Nashville, Tenn., where $1 hot dogs helped woo Predators fans back to Bridgestone Arena.
In Ohio, the Columbus Blue Jackets came on the ice for warmups wearing jerseys numbered 1 with "Thank You Fans" printed where the player's name is. The jerseys were then given to fans.
In Philadelphia, a city that hasn't sniffed a Stanley Cup parade since 1975, a record 19,994 fans showed up for the season opener against Pittsburgh. That came on the heels of more than 2,000 fans at their practice facility for the first day of training camp and another 15,000 showed up for a free, open practice at the Wells Fargo Center.
Across the state in Pittsburgh, Consol Energy Center was packed during a free intrasquad exhibition last week, with a couple thousand fans turned away at the door. Just to make sure the fans will stay satiated—as if watching Sidney Crosby isn't enough—the Penguins are giving those in attendance during the first four home games vouchers for free food and dropping prices on team merchandise by 50 per cent.
Yes, there's a good deal to be found in the NHL, and it's not just the collective bargaining agreement. It's slashed prices and freebies all offered to hockey-starved fans as a way of saying thanks for sticking by the sport over the 113-day lockout.
Crosby, the league's most famous player, wasn't surprised at how fans stuffed arenas around the NHL.
"I think it's great to see that we're still getting the turnout that we're getting," he said.
Can't get a ticket? No worries. There's always the comfort of watching on the big screen TV. While the NHL will never attract the oversized ratings of the NFL or other marquee sports, the numbers from the first few days of action show fans will plop down on the sofa and watch on high definition just as much as from high in the upper deck.
NBC's broadcast Saturday earned the league's most-watched game for a non-Winter Classic in 14 years. It was regional coverage of the Chicago Blackhawks defeating the Stanley Cup-champion Los Angeles Kings, 5-2, and Pittsburgh's 3-1 victory over Philadelphia. All told, 2.77 million viewers tuned in.
It was the most-watched regular-season coverage on NBC since the network again began broadcasting the NHL in 2006, and the highest since Fox drew 3.09 million viewers for a three-game regional slate in April 1999.
NBC's coverage peaked at 3.82 million viewers in the final minutes of the broadcast when most viewers were watching the Penguins lead the Flyers, 2-1.
Eight markets set local ratings records or milestones for regular-season coverage—not counting Winter Classics—that aired either on NBC or NBC Sports Network from Saturday to Tuesday.
"It's good to talk about something else besides the lockout and actually talk about the game," Flyers captain Claude Giroux said. "It's obviously a pretty good feeling out there having the fans. They are unbelievable."
Maybe it helped the league said it was sorry: The NHL bought full-page ads in about 40 newspapers across the United State and Canada thanking fans for their patience and apologizing for the lost games. The ad said the league was "committed to earning back your trust and support" with "hard work and unwavering dedication."
The abbreviated 48-game season where games matter more, at least in perception, than the usual October, November snoozers has helped fuel interest. So has opening over a slow portion of the sports calendar. Outside of the scandals that have piled up at a daily clip, there's not much to grab the average viewer outside of the Super Bowl. March Madness and baseball could cut into the viewing audience, but the Stanley Cup chase will be full blast by then.
Fans are forgiving but, of course, some are still angry at the league for wiping out a slate of games. Others have continued to follow through on their preseason pledges of ignoring the league. NHL fan Steve Chase started the grass roots "Just Drop It" campaign that encouraged fans to skip one NHL game for every game cancelled after Dec. 21. Ten games total. He asked fans to pledge they would not spend a penny or a minute of their time on tickets, TV, merchandise, all things NHL.
More than 21,000 fans had clicked the "like" button on the group's Facebook page as of Wednesday.
The page features a sign that says, "10 Games! Be Strong!" Chase said members of the group have told him they are honouring their vow and not doing much more than checking scores on their mobile devices or in newspapers.
"We totally expected there would be a mass exodus because hockey fans are hockey fans," he said. "That's been pretty impressive to see."
With some teams having played three games already since Saturday, those 10 games will whizz by like a slap shot.
Chase said he hasn't bought a ticket for a game this season and acknowledges, "I probably won't go back this year."
But when he turns on the TV for Game 11, he'll see plenty of fans willing to go in his place.


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GREENVILLE, Ill. -- The men's basketball team was outplayed by Fontbonne on Saturday as the Griffins won 78-72. Jordan Smith was the game's leader with 18 points.
Fontbonne took a 41-34 advantage to the locker room at halftime and held on despite Greenville's rally in the second half. Greenville was hurt by 20 turnovers during the afternoon.
In addition to Smith's 18 point performance, MarQuel Jones posted 13 points, and Alex Mumphard added 12 points. The game's leading rebounder was Simon Martin with 11 boards in 14 minutes of action.
Greenville (7-10, 2-6 SLIAC) resumes their season next Saturday when they travel to Blackburn for a 3 p.m. tilt with the Beavers.


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The largest Wall Street banks and foreign-based financial companies won a six-month delay in some swap regulations for overseas trades, even as they must begin registering with U.S. regulators by year-end.
The Commodity Futures Trading Commission, the main U.S. derivatives regulator, voted 4-1 to leave the registration deadline in place while providing a delay until July 12 for capital and other requirements for overseas operations of JPMorgan Chase & Co., Goldman Sachs Group Inc. and other banks, the agency said in a statement today. The CFTC also reduced the number of overseas offices immediately registering.
"There is a lot of work to be done with international regulators," CFTC Chairman Gary Gensler said in a telephone interview. "It's my firm belief that if reforms were not to cover the branches and affiliates of U.S. entities either directly or through substituted compliance the public would be left without critical protections."
The international reach of CFTC swap rules has been one of the most controversial elements of the agency's Dodd-Frank Act rules, prompting opposition from financial companies including JPMorgan, Goldman Sachs and Barclays Plc. The agency has also faced criticism from European and Asian regulators over the reach of a rule requiring trades to be guaranteed at clearinghouses and traded on exchanges or other platforms.
'Better Coordination'
"It is important that the commission provide relief for better coordination with regulators in other jurisdictions to avoid unnecessary fragmentation, duplication and conflict among rules for derivatives markets," Tim Ryan, president and chief executive officer of the Securities Industry and Financial Markets Association, said in a statement. The CFTC is working with international regulators to determine when overseas rules can be used to substitute compliance with Dodd-Frank measures.
Under the exemptive order, foreign-based banks and overseas operations of U.S. banks don't need to count trades they have with non-U.S. clients to determine whether they cross the threshold requiring registration with the CFTC. The agency also sought additional public comment on how to define U.S. entities and foreign branches of U.S. companies.
"We think it's appropriate to give some more time on the issues of substituted compliance and the issues as to how the overseas branches and overseas guaranteed affiliates will be regulated with their outwardly facing trades, not the trades facing the U.S.," Gensler said in the interview.
Dennis Kelleher, CEO of Better Markets, a Washington-based organization advocating stricter financial regulation, said the delay fails to protect U.S. taxpayers.
"Wall Street and its army of lobbyists will use the additional time to continue their war on financial regulation that may hurt their profits, but which will protect the American people from having to bail them out again," Kelleher said in a statement.
Copyright 2014 Bloomberg. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.


text:
Kosher : Yes
Size : 1.25 OZ
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WASHINGTON (AP) — The Supreme Court will take up the pregnancy discrimination claims of a package delivery driver for UPS who was refused a light duty assignment so she could continue working while pregnant.
UPS driver Peggy Young lost her health benefits when UPS would not grant her light duty or allow her to continue her regular job. Young says the company allows employees with some medical conditions to perform jobs in which they can avoid lifting heavy packages. She returned to work after giving birth.
Lower courts ruled that UPS did not violate the Pregnancy Discrimination Act in dealing with Young.
The case will be argued in the fall or winter.
The Obama administration agreed with Young, but said recent changes in federal law could cause courts to rule in another way.


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5 things to know about the 2017 Land Rover Discovery
The all-new 2017 Land Rover Discovery is one of those vehicles you could write volumes about. There are so many neat features, and the fact it's a seven-passenger vehicle that fits real adults and can hit some pretty tough trails is pretty cool, too.
So, in case our full first-look review of the 2017 Land Rover Discovery was TL;DR, I'm breaking out five important features on this all-new full-size SUV.
Clever storage
Who doesn't love a super secret spy compartment? The Discovery has a couple of them, including deep center console storage hidden underneath the front cup holders and another secret cubby behind the HVAC controls on the center stack. The former will hold up to four tablets, while the latter is great for hiding a phone or wallet.
In total there are 21 separate stowage areas including row-three cup holders, two tablet pockets, front and rear door storage compartments, a cooled box storage area under the center armrest ($350) and a twin glove box.
Hands-free liftgate
The kick-activated liftgate was pioneered by Ford, and various manufacturers have tried their own versions of the hands-free hatch including Hyundai's Smart Trunk, which is activated by key proximity, and Lexus' Touch-Free power door, which is activated with a wave of the hand over the rear Lexus logo.
Land Rover goes back to the kick-activated technology, allowing someone who has the key fob to walk up behind the vehicle and kick under the rear bumper to open the rear liftgate without touching anything. This is a great feature – especially if your hands are full.
The "gesture tailgate," as Land Rover calls it, is standard on the base SE trim.
21 seat configurations
You want seating options? If you opt for the seven-seat configuration, Discovery has tons of 'em. You can raise or lower each rear seat individually or as a group, and in all there are 21 different configurations. Plus, you have options on how to lower the seats: from the front touch screen, from the rear switches or from your cell phone.
We also like that the configurations can be completed within 14 seconds, so you can swiftly switch between hauling cargo or people.
What we really love: The remote operation via your phone. Say you're in Home Depot or IKEA buying some bulky home product. While you're waiting in line, you can pull out your phone and drop the seats in preparation of loading the cargo.
Discovery is standard with five seats on the SE and HSE trims, and the seven-seat configuration is a $2,150 package option. The Intelligent Seat Fold Package is available at the HSE trim for an additional $1,070. Both are standard at the HSE Luxury trim ($64,945).
Yes, it has a diesel
The base engine for the Discovery is a 3.6-liter supercharged V-6. However, a 3.0-liter 6-cylidner diesel engine is available for a $8,960 upcharge. The extra cash isn't completely due to the engine – the gasoline model is available in a base SE trim, whereas the diesel model starts at the HSE trim level.
The diesel delivers 254 horsepower and 443 pound-feet of torque – so it's great for towing, but a little light on the acceleration. Zero to 60 mph is achieved in 7.7 seconds (as opposed to 6.9 seconds in the V-6).
This engine is quiet and steady, and though fuel economy numbers haven't been officially released, Land Rover estimates it will get 26 mpg in combined driving.
Set your cruise control to 1 mph
Wait, what? Shouldn't you add a zero to the cruise control number? Nope. The new Discovery offers a cruise control that can be set to 1 mph, and this is specifically designed for rock-crawling off-roaders.
The available All-Terrain Progress Control maintains a crawl speed chosen by the driver, which then allows the driver to concentrate on steering.
All-Terrain Progress Control along with Terrain Response 2 is standard on the top-tier First Edition model ($74,945).
The 2017 Discovery will have a base price of $50,985, and it will be arriving in dealers sometime in May.


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Crime Without Punishment
An American Dream
This is, to my mind, the most eccentric of the four novels Norman Mailer has written. It is far more eccentric, I think, than Barbary Shore—his second novel and a better one than literary opinion has generally taken it to be—which alienated readers not so much by personal singularity as by the extreme sectarianism of its political theme. In the case of that work it might well be said that the reader, wholly unprepared for that kind of statement, was in a certain sense quite as much at fault for its failure as the author. This latest book, however, has very few if any of the qualities that redeemed Barbary Shore as well as Mailer's other fictions.
There is nothing here like the brilliantly observed comic episodes in The Deer Park (involving Hollywood producers Teppis and Munshin) or the powerfully sustained narrative-sequence comprising the second part of The Naked and the Dead (the Sergeant Croft section). And the title, An American Dream, strikes me as a misnomer. It implies a generalization about the national life palpably unsupported: either by the weird and sometimes ludicrous details of the story or by the low-level private mysticism informing its imaginative scheme. That mysticism is more or less pseudonymously presented in Mailer's articles under the flashy and ostensibly impersonal heading of Hip. Now whatever the origin of the term in the underworld of jazz and narcotics, the explication of it that he has been engaged in for some years is at bottom scarcely a report on something that exists outside himself, but is basically a programmatic statement of his own desires, power-drives, and day-dreams. It amounts to a kind of personal mythology projected onto something he chooses to call Hip. I venture to say that real-life hipsters, not romantic youths reading Mailer with relish, would hardly recognize themselves in his free-wheeling description of their motivation and behavior.
The time of this new novel's action is thirty-two hours, and its frantic action consists of a great deal of sexual activity. It is centered on a murder—the protagonist's killing of his wife, a bitchy wealthy heiress—during a violent tussle in which hard words and harder blows are exchanged. It is true enough that the murder is unpremeditated, but it can not be said that this act of ultimate violence committed by Stephen Rojack, the protagonist, is merely an accident; in fact he commits it with enormous exhilaration. Already on page 8, before the episode of the killing is introduced, Rojack acknowledges that he had long known there was murder within him, and he speculates that the exhilaration accompanying it must come "from possessing such strength." "Besides," he adds, "murder offers the promise of vast relief. It is never unsexual." (How would he know that, since these thoughts occur to him prior to the experience itself?) Moreover, the long paragraph describing Rojack's choking Deborah to death is full of…
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|This company has recently been acquired or received a credible acquisition offer.
Wachovia was established in 2000 through the merger of First Union and the predecessor Wachovia Corporation. A series of mergers and acquisitions developed the basis of what the company is today. Recent transactions provided the firm with an increasing market share along the south-eastern United States. Before 2005, the company was known throughout the east coast as a premier commercial bank that focused on middle-market and small business banking. In 2006, the company acquired Golden West Financial and Westcorp is entering the west coast banking environment which has been predominantly served by Bank of America and Wells Fargo. In 2007, Wachovia also completed its acquisition of A.G. Edwards & Sons, Inc.
Wachovia's revenues are well diversified among its 4 key businesses:
With a presence in 21 states, Wachovia focuses on individuals, governmental agencies, small businesses, and commercial entities. Mortgage services are sold in 50 states, and auto financing is offered in 46 states. Small businesses have been a particular strong point in the company's recent financial press release. The bank provides a individualized level of service depending on a client's revenue.
Commercial banks typically make money by paying depositors a lower interest rate than they charge on the mortgages that they fund through their deposits. This becomes increasingly difficult in the current environment, in which short term interest rates are higher than long term interest rates.
Wachovia provides financial advisory services to high-net-worth clients, families, and enterprises. The company also provides insurance services which include risk management, employee benefits, and corporate insurance plans.
Capital raising, mergers and acquisitions advisory services are among the specialties offered in this division. The firm specializes in advising private equity shops, hedge funds, and other firms in the financial services sector. The Corporate & Investment Bank also engages in investments in start-up firms, asset-based lending, as well as cash-holding services to its clients among other offerings.
Investment retirement plan and brokerage services are provided under this arm of the Wachovia Corporation. With offices in 47 states and in Latin America, the firm is poised to take advantage of its strong asset management team based in Evergreen Investments. The asset management team focuses on institutions, endowments, as well as advising pension funds.
Loan defaults, particularly in the subprime market have increased dramatically in recent months. As interest rates rose many borrowers find themselves at the mercy of their once low adjustable rate mortgages. Moreover, higher interest rates raise the cost of borrowing for all lenders, dampening overall demand for mortgages and other home loan products.
Typically banks charge higher interest rates on loans which qualify as long term debt than they they pay on deposits (short term debt). With the yield curve inverted, long-term rates are lower than short-term rates, making deposit accounts left profitable.
Domestically, Wachovia has a strong presence on the east coast, and with the recent acquisitions on the west coast, it will enter California, Arizona, Nevada, Colorado, and Texas.
The firm has made strong progress in entering the Latin American markets which has seen very strong growth in the real Gross Domestic Product in the past couple of years.
Mobile Banking: Banks across the industry have made progress into mobile banking issues. In 2006, the major banks including J P Morgan Chase (JPM), Citigroup, and Commerz Bank launched a campaign to open as many ATMs as possible. The idea of convenience is extended to a new level by phone-based mobile banking. Basic services like account management and fund transfers are among the possible options for mobile banking. Most importantly, it represents an outlet for those lacking bank accounts, are undocumented, and poor.
Remittances: With Bank of America (BAC) taking the first move into the remittances market, competitors and start-ups are taking small steps into the industry. At present, this segment represents a significant source of untapped revenue with very little competition.
The major players in Wachovia's league are Citigroup (C), Bank of America (BAC), and SunTrust Banks (STI) These firms typically operate in a business model that gradually introduces clients to complex financial services and solutions as the client matures. In this way, these banking firms try to cater to the client's entire life span by offering as many products as possible. For this reason some have identified this strategy as building "banking supermarkets."
|Domestic Deposit Market Share (%)
|Bank of America (BAC)
|J P Morgan Chase (JPM)
|Wachovia (WB)
|Wells Fargo (WFC)


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Never Highlight a Book Again! Just the FACTS101 study guides give the student the textbook outlines, highlights, practice quizzes and optional access to the full practice tests for their textbook.Economics, Economics Cram101 Textbook Reviews. ANSWER KEY 1. d 2. d 3. b 4. b 5. b Take the Complete Practice Test Chapter 18. Global Economic ... Additional Facts101 eBooks and Tests Want More? JustTheFacts101.com.
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35% Cotton
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APACS SPORTS was established in year 2002 to promote and distribute high quality sports equipments in local and international market.
Copyright © 2014 Apacs Sports (M) Sdn. Bhd. All Rights Reserved. web design by : : syscomm : : All products and photos mentioned are trademarks or registered trademarks of their respective owners.


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William Gould has more than 44 years of architectural preservation and restoration experience. His company provides architectural planning and analysis, historic design and preservation consulting, dismantling and relocating historic structures as well as most aspects of restoration contracting. His range of experience covers the 17th, 18th, 19th centuries plus architecturally significant 20th century properties. From the woodshop comes all the architectural detail required for all his projects. These included Connecticut's Old State House, properties of the Antiquarian and Landmarks Society, Hartford's 350th anniversary replica, plus religious, public, private and institutional structures from Western Connecticut to Eastern Massachusetts.
Mr. Gould's workshop:


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The most significant findings of the impressions study show advertising specialties are less expensive per impression than most other media and are very affordable and effective when compared to other forms of media.
Key findings of the study include:
At $0.005, the average cost-per-impression (CPI) of an advertising specialty item is less than nearly any other media. According to data obtained by ASI the CPI for a national magazine ad is $0.045; for a newspaper ad, $0.029; for a prime-time TV ad, $0.018; for a cable prime-time TV ad, $0.005; for a syndicated daytime TV ad, $0.005; and for a spot radio ad, $0.058.
To complete its research, ASI conducted a total of 3,332 online and in-person surveys, including interviews with businesspeople in New York, Chicago, Los Angeles, Philadelphia, London, Sydney, Toronto and Montreal metro areas.
The 2.0 study, a follow-up to the definitive 2008 survey, includes new demographic information on politics, ethnicity, gender and age, since knowing the likely recipient of products is paramount for an advertiser. This year, the comprehensive report also adds global markets and includes more products, such as automotive accessories and food.


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quote:overhead lights blurring past, the sound of gurney wheels on shiny tiled floor. An eternal elevator ride with an orchestral version of Dear Prudence piped in from hell. Then a face in a spacesuit hanging over him, No, definitely not pneumonia, this is something new. Put him in isolation, 6C.
quote:Originally posted by Notwald: I remembered that the whole point is to try to improve the selection based on the comments!
quote:He blinked slowly, licked crusted lips.


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When I was packing my suitcase for Denver, I made sure to throw in a purple sweater.
One of the biggest threats to the well-being of our nation's women and families is poverty.
In a significant victory for workers in Philadelphia, the City Council voted 15-2 to pass a provision providing workers at businesses that contract with or receive financial support from the city to the right to earn paid sick days.
Hi, all. It's Helen, work and family policy associate at the National Partnership.
After 10 days of volunteering with the Campaign for a Healthy Denver, I am headed back to D.C.
We are just one week away from the deadline for Denver voters to turn in their ballots — and vote YES on Initiative 300.
Hi, everyone! I'm Katie, a legal fellow at the National Partnership.
One of the first questions I asked when I hit the ground here in Denver was "Where are we going to eat?"
Hi, everyone! I want to share a great letter published in the Denver Post this week.
Over the weekend, Sara and I delivered lawn signs to nearly every corner of Denver.
In a place this picturesque, it is hard to believe that some working families are facing grim challenges every day because they don't have basic paid sick days.
Hello again! I wanted to send a quick note to let you know that the Campaign for a Healthy Denver is on TV!
Hello from the Mile High City! This is Rachel Lyons, work and family government affairs manager at the National Partnership, reporting live from Denver — home of the Broncos, the unsinkable Molly Brown and, hopefully, the fourth citywide paid sick days law.
Hello, PaidSickDays.org! I'm Sara, an intern at the National Partnership for Women & Families and a proud volunteer with the Campaign for a Healthy Denver.
This year, we have achieved significant victories in our work to ensure more working people have the right to earn paid sick days.
|Items 21 - 40 of 93


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Delta Center renamed to honor Superintendent T.E. 'Jake' Fisher
On Sept. 2, MU Vice Chancellor and Dean Thomas Payne, College of Agriculture, Food and Natural Resources, announced the Delta Center would be renamed the T.E. "Jake" Fisher Delta Research Center to honor the dedication and leadership of retiring superintendent, T.E. "Jake" Fisher.
The Sept. 2, 2011, Field Day at the University of Missouri's Delta Research Center in Portageville, Mo., was like previous events with thousands across the region with friends and industry professionals dropping by to learn about the latest advances in regional agricultural research. It also saw two milestones: it was be the 50th field day held at the center, and will see the retirement of its long-serving supervisor, T.E. "Jake" Fisher.
Fisher has attended every one of the center's 50 field days. In 1961, the freshly-graduated Fisher started work there as an entry-level tractor driver. During his tenure, he helped the Delta Center mature from one greenhouse to a research complex helping Missouri's billion dollar soybean, wheat, cotton and rice industry be more productive. The center's commitment to community service that has made it and its Field Day a must-stop for governors, senators, industry leaders, farmers and kids.
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Campus: UMC
Key words: Agriculture, Teaching, Technology, UM System,
County: New_madrid


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AMD Wireless Display (AWD) supports the connection of an additional display without the need of a video interface cable. Experience games or watch videos on the big screen, wirelessly, by systems powered by select AMD Accelerated Processing Units (APUs)1.
The following recommended components are manufactured by AMD partners. Please consult with the manufacturer to ensure the devices meet your requirements.


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|Page (1) of 1 - 01/10/12
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4 dead in apparent murder-suicide in OhioSheriff: Ohio man killed himself, son and 2 in-laws; relatives say man's wife terminally ill
LOGAN, Ohio (AP) ' A family dispute and standoff with police ended when a man caring for his terminally ill wife apparently shot and killed her two sisters and his son before fatally shooting himself, authorities said.
A cousin said the man was upset that the relatives were keeping him from spending time alone with his cancer-stricken wife, who was not shot.
Deputies who stormed the home around 9 p.m. Monday found the man dead on the front porch and the three other bodies on the living room floor, Hocking County Sheriff Lanny North said.
Officers had been waiting outside for hours since being called about a possible hostage situation at the house amid rolling, wooded hills dotted with farmland near Logan, about 50 miles southeast of Columbus. A person who had been held hostage was able to flee, the sheriff told reporters.
The gunfire erupted after some type of family squabble, North said. It was over jealousy, said Matthew Henderson, 45, a cousin of the man.
"They ' the two sisters and his son ' were staying out there, and he said he couldn't spend any time with her," Henderson said.
A sheriff's dispatcher said Tuesday he had no information on the names of the victims and the shooter. The sheriff's office planned to issue a news release later in the day.
The Westerville school district in suburban Columbus identified the slain son as Leroy Gilkey, 38, a high school Spanish teacher.
Gilkey was "a very well loved and well respected teacher among students, among his colleagues and among the families that send their children to Westerville North (High School)," said Greg Viebranz, a spokesman for the school district.
Henderson said his own wife happened to call the home immediately after the shooting and spoke with the ailing woman, who said that her 63-year-old husband "shot everybody" and then went outside.
"I said, 'What's he doing?' (She said) 'I think he's waiting on more people to come so he could kill them,'" Henderson recounted.
The wife didn't say why she'd been spared, Henderson said. "I think he thought if he would kill her he would go to hell," he said.
Henderson said his cousin had recently bought two or three plots at a cemetery, though it didn't seem unusual for a man whose wife had terminal cancer. He described his relative as unpredictable and unstable and said that he might have taken some pills and been drinking before the shooting.
"I thought what would happen is that he would wait until she passed away and then he would shoot himself," he said. "I didn't think he would shoot other people, I thought he would take his own life."
Neighbors said they were shocked by the bloodshed. John Poling, who lives about a quarter-mile down the road, said he didn't know the couple but believed they had moved into their home within the past 10 years. He said he watched from a distance Monday night as law enforcement and SWAT officers closed in.
The killings have rocked the area, the sheriff said.
"This is normally a pretty quiet county," North said. "We have a few major crimes occasionally but nothing of this magnitude."
Associated Press writer Doug Whiteman in Columbus contributed to this report.
Kantele Franko can be reached at http://www.twitter.com/kantele10.
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Related Keywords:Hostage Standoff-Shootings,Suicides,Violent crime,Crime,General news,Hostage situations


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The U.S. Secretary of Education shares his back-to-school success secrets for your family.
For him, it's personal. As the parent of a first-grader and a third-grader, both of whom attend public school in Arlington, VA, U.S. Secretary of Education Arne Duncan (above) has a really big stake in this country's school system. He's got some serious priorities in Washington, but he's also set some goals for parents like you. Follow his five suggestions and watch your child's future soar:
1. Friend your child's teacher Have an ongoing conversation; don't chat just once or twice a year. If the only time you show up is on report-card day, something is wrong. "I am in awe of what teachers get done every single day," Duncan notes. "I would not underestimate the power of parents and students going to the teacher and saying 'Thank you.' They did not go into teaching to make a million dollars—they did it for that personal human connection."
2. Power down "Technology can accelerate learning, but it can also be a huge distraction that can make kids passive," Duncan says. "Parents are stressed and distracted, too, and it becomes too easy to turn on the TV. I grew up without a TV in my house—I used to sneak over to my friend's to watch it—and we try our best to keep the TV and video games turned off in our home now, too."
3. Make some time Even if you can't run the PTA fund-raising committee or be the class mom, there is a way to help. For loads of suggestions on simple ways to do your part, see "The Busy Mom's Guide to Helping at School," page 118.
4. Have family dinners often It doesn't matter what's on the table (yeah, even the Duncans have pizza night!); what matters is that parents and kids score time to unwind and chat without any distractions.
5. Read out loud—together "We sit in the living room and read as a family—sometimes it's twenty minutes, sometimes it's an hour. It depends on when I get home, soccer practice, if it's a weekend. It's about the routine, and it's something I loved as a kid," Duncan recalls fondly.
The U.S. Secretary of Education shares his back-to-school success secrets for your family.


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Published: 29 Jun 2015
Winner, 2014 Electronic Book Competition, New Rivers/Mankato State U. "We feast on ample setting and White's knack at character illumination. The author manages to build a solid story footing, trow... more info
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15 U.S. Code § 1272 - Publicity; reports; dissemination of information
The Commission may cause to be published from time to time reports summarizing any judgments, decrees, or court orders which have been rendered under this chapter, including the nature of the charge and the disposition thereof.
The Commission may also cause to be disseminated information regarding hazardous substances in situations involving, in the opinion of the Commission, imminent danger to health. Nothing in this section shall be construed to prohibit the Commission from collecting, reporting, and illustrating the results of the investigations of the Commission.
2008—Subsec. (a). Pub. L. 110–314, § 204(b)(4)(B), substituted "Commission" for "Secretary".
Subsec. (b). Pub. L. 110–314, § 204(b)(4)(B), (C), substituted "Commission" for "Department" after "investigations of the" and for "Secretary" wherever appearing.
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


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The Age of Intellectual Property?
Are we in the Age of Intellectual Property?
It's become a truism in IP scholarship to introduce a discussion by acknowledging the remarkable recent rise in popular, scholarly, and political interest in our field. Thus readers will recognize a familiar sentiment in the opening line of Amy Kapczynski and Gaëlle Krikorian's new book:
A decade or two ago, the words "intellectual property" were rarely heard in polite company, much less in street demonstrations or on college campuses. Today, this once technical concept has become a conceptual battlefield.
Only recently, however, has it become possible to put this anecdotal consensus to empirical test.
In December 2010, Google launched ngrams, a simple tool for searching its vast repository of digitized books and charting the frequency of specific terms over time. (It controls for the fact that there are many more books being published today.)
If you haven't already played around with this tool to explore your own topics of interest, you should. While you're at it, take a stab at explaining why writing on the Supreme Court rose steadily until approximately 1935 and has dropped just as steadily ever since!
Back to our topic, though. What does this data reveal about the prominence of intellectual property in published discourse?
I generated two graphs, both charting the terms "intellectual property," "copyright," "patent," and "trademark." First, the longview:
Read More


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In what seems to be the growing trend of motorcycle startups latching onto the growing EV market, the Agility Saietta debuted today at the Carole Nash MCN Motorcycle Show in London. The design is likely going to be a love or hate affair for most riders, and we doubt it'll do anything to convince petrol-heads that electrics are the future of this industry, but the Saietta packs some seriously dubious performance claims, which if true should impress performance geeks.
Engadget is reporting an ambiguous performance figure from Agility of 675 hp/ ton, which would work out to 169hp on a 500 lbs motorcycle, and 135hp on a 400 lbs machine. Spying the air-cooled brushed DC Agni motor nestled within, we imagine that figure is peak power rating, and as we've seen at the Isle of Man TT, those Agni motors are finicky about running at those power levels for extended periods of time.


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Preservative Tech In Retrospect
Last month, as you may recall, we talked our friend, John Fleming of Boulder City, Nevada, down from having us bodywork and refinish his cherry, original 1957 Chevy 210 two-door sedan—in Resale Red acrylic urethane. The reasoning behind our reasoning is that a car is only original once, and this old car's original lacquer finish has an honest weathered appeal worth preserving.
With bodywork and rust repair chores now behind us, we're back in the booth for the application of hard-to-find PPG Duracryl acrylic lacquer topcoats. The roof panel will be refinished in its entirety, while the silver on the sides will be blended and distressed to match the car's existing finish; and we'll get to use some old tech tools and materials that don't ordinarily come into play.


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Sofia Vergara attended the 2017 Golden Globe Awards on Sunday (January 8), then won Favourite Comedic TV Actress at the People's Choice Awards 2017 on Wednesday (January 18) in LA.
2017 Golden Globe Awards: Like so many other stars, the actress had on sheer and metallic for the evening in a Zuhair Murad Fall 2016 Couture design. The cold-shoulder gown and her sleek ponytail were a bit of a departure for the vivacious Colombian beauty who typically gravitates towards mermaid silhouettes and long bombshell locks.
2017 People's Choice Awards: The familiar silhouette near and dear to her heart was back in action with this seductively curve-hugging Marchesa Pre-Fall 2017 design with gold bustier top. While the mood of the dress was decidedly luxe, the platform stilts she wore on her feet were decidedly not. Sometimes looking seven feet tall simply isn't worth it.
Credit: Vogue.com & Getty