text:
L. G. Biesecker, et al
Includes from NHGRI: L. G. Biesecker, M. J. Lindhurst, J. C. Sapp, J. K. Teer, J. J. Johnston, K. Peters, J. Turner, P. L. Schwartzberg, J. C. Mullikin
Proteus syndrome manifests mosaic overgrowth in skin, connective tissue, brain, and other tissues. It was hypothesized to be caused by a mosaic mutation, lethal in the non-mosaic state. We tested this hypothesis using massively parallel sequencing of DNA from Proteus syndrome tissues, comparing affected to unaffected tissues. Seventeen samples from 11 patients were sequenced using targeted exome capture. These samples included four affected-normal sample pairs, two affected samples from a fifth patient, one pair of samples from discordant monozygotic twins, and five unaffected parents. We generated ~1.6 Gb of sequence data, with >87% coverage of exons with a high quality genotype. A novel variant was initially identified in a single affected sample using an affected-unaffected filter. Upon manual examination, we found this variant in three additional affecteds but not in the parents of affecteds or the unaffected identical twin, 1000 genomes (n=634), or ClinSeq (n=401). The sequence variant data were confirmed and extended by a custom restriction enzyme assay of >150 samples from 29 patients. Most affected samples were specimens removed from clinically abnormal areas at surgery. Twenty-seven of 29 patients with Proteus syndrome were found to have the identical mutation in this gene, but it was not present in >20 cell lines and tissues from persons with unrelated disorders. Tissues and cell lines from patients with Proteus syndrome harbored admixtures of mutant alleles that varied from 1% to ~50%. Patient-derived cell lines with the mutation showed evidence of activation of this gene product using anti-phosphoprotein antibodies and western blot analyses. We also show that a pair of single cell clones established from the same starting culture and differing only by their mutation status had differential activation of this protein. We conclude that a somatic mosaic activating mutation in this gene causes Proteus syndrome, validating the Happle mosaicism hypothesis. That this mutation is the same in all patients, mosaic, and not in a CpG dinucleotide explains the rarity of this disorder. These data show the power of massively parallel sequencing to identify causative genes in disorders that are not amenable to positional cloning. Further, these results provide a therapeutic target for this severe and progressive disorder. (The author confirms that the gene and mutation will be disclosed at the ICHG meeting, should the abstract be selected).
T. Vilboux, et al
Includes from NHGRI: C. F. Boerkoel, Y. Huang, D. Maynard, H. Dorward, K. Berger, J. C. Mullikin, M. Huizing, W. A. Gahl, M. Gunay- Aygun
Gray Platelet Syndrome (GPS) is a rare autosomal recessive disorder characterized by bleeding tendency, myelofibrosis, thrombocytopenia, and large platelets that lack ±-granules. The causative gene has been sought for decades. We mapped the locus for GPS to a 9.4Mb interval on 3p21.1-22.1 that included 197 protein-coding genes. We sequenced these genes using a combination of next generation and Sanger sequencing in 15 independent GPS families. We identified 15 different mutations in NBEAL2 (neurobeachin-like 2); 5 missense, 4 frameshift, 3 nonsense and 3 splice site mutations. The protein encoded by NBEAL2 has no known function, yet; however, it belongs to a family of proteins that contains 3 domains (BEACH, ARM and WD40) that are crucial for protein-protein interactions, membrane dynamics and vesicle trafficking. Another protein from this family, LYST, a lysosomal trafficking regulator protein, is defective in Chédiak-Higashi syndrome, a disorder associated with platelet dense granule abnormalities in addition to giant secretory granules in leukocytes and other cell types. RNA analysis showed that at least 7 NBEAL2 mRNA transcripts are expressed in hematopoietic cells, including megakaryocytes and platelets. Mass spectrometry of discontinuous sucrose gradient platelet fractions localized NBEAL2 protein to the platelet dense tubular system (endoplasmic reticulum). Microarray data in GPS fibroblasts showed overexpression of fibronectin, essential for proplatelet formation in cultured megakaryocytes and critical for megakaryocyte-matrix interactions. This could explain the myelofibrosis seen in GPS patients and therefore can be explored as a therapeutic target. Understanding NBEAL2 function will likely lead to the discovery of novel pathways of organelle formation and maturation.
K. V. Fuentes Fajardo, et al
Includes from NHGRI: M. Huizing, M. Nehrebecky, F. Gill, C. F. Boerkoel, A. R. Cullinane, W. A. Gahl
Advances in Next Generation Sequencing technology (NGS) have made transcriptome sequencing a practical reality for clinical research applications. Exome sequencing as a tool for finding genetic causes of diseases has become prominent in the literature, and is chosen as the major NGS technology when following up cases in the NIH Undiagnosed Diseases Program (UDP) Protocol. To date, no diagnosis has been arrived at through leads from transcriptome research. The UDP's first attempt at transcriptome sequencing in a clinical setting involved a 50 year-old Caucasian woman with a unique phenotype that included widespread spiny follicular hyperkeratosis resulting in scarring alopecia, follicular plugging and skin abscesses. Her initial milder lesions were exacerbated by a combination of UV-A light treatment and oral retinoids. Thorough dermatologic and medical evaluations to rule out infectious, endocrinologic and paraneoplastic etiologies were unhelpful in delineating an etiology and in clearing the skin problem. Histology and candidate gene sequencing were not diagnostic. Here we present the analysis of transcriptome sequence variations found in RNA from keratinocytes and fibroblasts from involved skin contrasting and comparing them to those found in RNA from fibroblasts and keratinocytes from unaffected skin, blood, and the reference human genome sequence. We identified 18 mutations unique to the keratinocytes and fibroblasts from affected areas, including two genes that indicate a "second-hit," causing additional damage to a gene already harboring a missense mutation. We also observed that deleterious germline mutations were enriched for genes in cell adhesion, cell transport and immune response (p=0.00002, Bonferroni). These data demonstrate the ability to use RNA-Seq to find genes that carry deleterious mutations and demonstrate dysregulation of expression. These findings can then guide follow-up targets for diagnostic and treatment decisions.
J. L. Sloan, et al
Included from NHGRI: J. J. Johnston, I. Manoli, R. J. Chandler, C. Krause, N. Carrillo-Carrasco, S. D. Chandrasekaran, J. R. Sysol, K. O'Brien, N. S. Hauser, J. C. Sapp, H. M. Dorward, M. Huizing, N. I. H. Intramural Sequencing Center, L. G. Biesecker, C. P. Venditti
Combined methylmalonic and malonic aciduria (CM a.m.MA) is characterized by increased urinary methylmalonic acid (MMA) and malonic acid (MA), with MMA>MA, and normal malonyl-CoA decarboxylase activity. CM a.m.MA was first reported in a child with failure to thrive, seizures and immunodeficiency and a dog with neurodegeneration but the molecular etiology was unknown. We performed exome sequencing of a patient with CM a.m.MA and her parents and filtered variants to identify 12 candidate genes. One of these genes had a putative mitochondrial leader. We sequenced this gene in 9 patients and found two mutations in this gene in 8 of 9 patients. DNA from the dog also had a homozygous mutation in this gene. Mutations included 9 missense, 1 in-frame deletion and 1 nonsense mutation. Eight missense mutations and the in-frame deletion were in functional motifs conserved among members of this enzyme family. One patient with 2 mutations was identified in an exome cohort of subjects not ascertained for metabolic disease and had the distinct biochemical features of CM a.m.MA. The age of diagnosis and symptoms in the nine subjects with CM a.m.MA were highly variable. MMA and MA were elevated in plasma and urine using a new GC-MS assay developed to measure MA. Fibroblasts from 4 subjects had a cellular metabolic defect; increased production of MMA (2.4- to 6-fold) compared to controls, after loading with 5 mM propionate. Viral overexpression of the candidate gene, but not GFP, corrected the metabolic defect. Immunostaining of fibroblasts overexpressing a C-terminal GFP fusion protein or the native enzyme showed a mitochondrial distribution and co-localized with a mitochondrial antibody. These data establish the causative gene for CM a.m.MA and describe the first disease association with a member of this enzyme family. Mutant alleles occur with a minor allele frequency (MAF) of 0.0058 in ~1,000 control individuals predicting a CM a.m.MA population incidence of ~1:30,000. This predicts that CM a.m.MA is one of the most common forms of MMAemia, and perhaps, one of the more common inborn errors of metabolism. The spectrum of symptoms and natural history of this disorder are highly variable and require further delineation. The identification of an affected using exome sequencing highlights an interesting and alternative diagnostic approach because CM a.m.MA is not identified through routine newborn screening by elevated propionylcarnitine.
C. Rotimi NHGRI/NIH
Large-scale genomics research projects — especially those that involve plans for the broad release of samples and data — raise many ethical issues. These issues are heightened in the context of international collaborations (for example, the International HapMap Project, the 1000 Genomes Project, and The Cancer Genome Atlas, and the International Human Microbiome Consortium), where different sets of cultural values and norms, and different legal and regulatory requirements, may have to be reconciled. For example, approaches to recruitment, informed consent, and individual autonomy and privacy vary considerably in different parts of the world. Attitudes about the role (if any) for community consultation or engagement and the appropriateness of particular research governance mechanisms can also differ. In addition, people in different parts of the world (and often even in the same part of the world) may have very different views about whether, or how, research results or incidental findings should be returned to participants in genomics research studies (where the samples and data have not been anonymized). The scope of the right to withdraw samples or data from repositories or databases is also an area of potential difference-especially where full realization of a project's end goals depends on having the samples and data available through a central repository to multiple researchers over an extended period of time. This session will explore these and other ethical issues that arise in large-scale international genomics research collaborations. Perspectives will be presented from several continents and countries.
E. Manoli, et al
Includes from NHGRI: J. R. Sysol, J. L. Sloan, R. J. Chandler, C. P. Venditti
We generated mice that express methylmalonyl-CoA mutase (Mut) cDNA under the control of a liver-specific promoter on a knockout background (Mut-/-;TgINS-Alb-Mut) to model extrahepatic manifestations, study pathophysiology and examine therapeutic interventions. Low-level hepatic Mut expression conferred complete rescue from the neonatal lethality displayed by Mut-/- mice and allowed disease-associated renal pathology to be induced with a high-protein diet. Ingestion of a high-protein chow for 2 months resulted in elevated plasma methylmalonic acid levels (¼M) in the Mut-/-;TgINS-Alb-Mut mice (1500 620) compared to similarly-treated Mut+/- littermates (7.4 ±0.6), growth failure and increased mortality. Mut-/-;TgINS-Alb-Mut mice developed tubulointerstitial nephritis associated with a decreased glomerular filtration rate (GFR) [37.6 3.9% of Mut+/- GFR, p<0.0001] and elevated creatinine levels. Mitochondria of proximal tubular epithelial cells were enlarged and had shortened cristae; kidney immunohistochemistry showed increased succinate dehydrogenase and decreased cytochrome c oxidase staining. Expression analysis using whole kidney RNA from the protein-challenged Mut-/-;TgINS-Alb-Mut mice compared to age, sex and diet matched littermates revealed differentially expressed mRNAs from several pathways including immune response, lipid metabolism, ketone biosynthesis and cell survival. One significantly up-regulated gene encoding a secreted glycoprotein was also increased in the plasma and urine of Mut-/-;TgINS-Alb-Mut mice and the concentration correlated inversely with GFR (r=-0.45; p<0.01). This protein was further studied in the plasma of 46 mut MMA patients (NCT00078078); levels were strongly associated with renal indices (patient plasma creatinine and cystatin-C values; p<0.01 for both). The inclusion of ubiquinol and vitamin E in the high protein diet for 2 months ameliorated the loss of GFR in the Mut-/-;TgINS-Alb-Mut mice (37.6 ±3.9% [pre-] vs. 60 ±4.8% of Mut+/- GFR [post-treatment], p<0.01) and normalized urinary and plasma disease-associated biomarkers despite persisting metabolite elevations induced by the dietary challenge. This novel mouse model has allowed identification of new biomarkers using genomic approaches and provided evidence for a therapeutic effect of antioxidants on the renal disease of MMA. These results should have broad extension to other metabolic disorders manifesting mitochondrial dysfunction.
M. J. Lindhurst, et al
Includes from NHGRI: J. K. Teer, J. J. Johnston, E. M. Finn, J. C. Sapp, J. C. Mullikin, L. G. Biesecker
Detection of mutations in mosaic samples is challenging due to the variability in the level of the mutant allele that can occur in various tissues. Recently, we have shown that Proteus syndrome is caused by a somatic mutation that results in constitutive activation of a key signaling pathway in affected tissues. The variant was initially identified using next gen sequencing of 17 samples. To confirm and extend these findings, we screened 158 samples by Sanger sequencing. Seventy-one of these samples had clear evidence of the mutant allele on the electropherograms, 17 had electropherograms that suggested a low level of the mutation, and 70 were apparently negative. However, it was challenging to distinguish low levels (<1%) of mosaicism from background signals or noise in the electropherogram traces. We next developed a PCR/restriction endonuclease assay (MboII) that could be separated on the ABI3130 and was designed such that MboII digested only the mutant amplicon. Areas under the curve for the mutant and wild-type peaks on the instrument were assessed quantitatively. A validation experiment using dilutions of cloned mutant and wild-type DNA showed a correlation of r2=0.9993 with a lower limit of 1% mutant allele sensitivity. Using this assay, the mutant allele was detected in all 71 of the positive samples, 15 of the above 17 samples that were suggestive and 15 samples of the 70 samples that were negative by Sanger. This increased the number of patients with at least one positive sample from 23 to 27. The level of mutation in these samples ranged from 1% to ~50%. We screened 75 samples from non-Proteus individuals; all were negative for the mutation. While the PCR/MboII assay increased sensitivity compared to sequencing, variation increased at low mutant allele levels (again, <1%). To address this, we PCR-amplified the mutation from 12 samples using indexing primers and used next-gen sequencing to generate ultra-deep coverage. These samples were pooled, and sequenced on a single GAIIx lane (76 bp paired-end). 28,568,780 total reads were generated, and 335,378-1,649,523 reads were assigned to each sample. Allele frequencies were calculated at the variant position, and agreed well with the MboII results. Additional optimizations will be performed and have the potential to further improve sensitivity. (The authors confirm that the gene and mutation will be disclosed at the ICHG meeting should the abstract be selected for presentation).
S. Hahn, et al
Includes from NHGRI T. Vilboux, W. Gahl
PURPOSE: There are many genetic diseases that would benefit from early diagnosis but that have no population screening platform. Examples include primary immunodeficiency disorders such as X-linked agammaglobulinemia (XLA), Wiskott Aldrich Syndrome (WAS), and Severe Combined Immune Deficiency (SCID), as well as nephropathic cystinosis. BTK, WASP, CD3 µ and cystinosin are low abundance proteins deficient in these conditions. They are localized in cell membranes, cytoplasm, or on the cell surface and are not detectable in plasma. We propose that these proteins can be observed in proteolytically digested extracts of WBCs and will be absent or significantly reduced in affected cells, making diagnosis possible. METHODS: Candidate peptides were screened by in silico trypsin digestion modeling followed by a BLAST search to insure that the sequences are unique within the human genome. The final signature" peptides were selected by evaluating the MRM chromatogram for the isotopically labeled peptide and the WBC digest peptide in control (n=20) and patient samples. Five lymphocyte cell lines were used to establish the absence of signature peptides for primary immunodeficiencies. Three PBMC samples from XLA were blindly analyzed. WBCs from 10 cystinosis patients with known genotypes were also tested. The amount of each peptide in the WBC was determined by taking the ratio of the peak area for the signature peptide to that of the labeled peptide and reported as normalized to actin. RESULTS: Three blinded samples lacked only BTK peptides, confirming that these samples were from XLA patients. All five cell lines clearly showed the biochemical phenotype of each cell line. Cystinosin was non-detectable in 9 cystinosis patients. One patient showed a cystinosin peak but at a very low concentration compared to control. CONCLUSION: Our method quantified the proteolytic peptides for the target proteins, BTK, WASP, CD3 µ and cystinosin in various cell lines and patient samples. Targeted proteins from these conditions were either absent or significantly diminished. This approach can be potentially utilized as part of a multiplex analysis for many genetic conditions in which the protein of interest is significantly reduced. While the transition from white blood cells to dried blood spots will be challenging, we believe that with further enrichment and optimization, this method can be potentially applied to newborn screening.
For a full list of NHGRI presentations at ASHG, including abstracts of research, please go to Participation from the National Human Genome Research Institute (NHGRI)
To view the PDF document(s) on this page, you will need Adobe Reader.
Last Reviewed: May 24, 2012


text:
What if William Shakespeare had written Star Wars? Well now we know!
Ian Doescher, author of "William Shakespeare's Star Wars: Verily, A New Hope" pulls back curtain on the eternal question: what does a wookie sound like in Elizabethan English?
Book Excerpt: 'William Shakespeare's Star Wars'
By: Ian Doescher
BIGGS: Make haste, O Luke. Methinks they do approach
E'en faster than before. I shall not hold
Them back for long!
LUKE: —Now, R2, straight increase
The pow'r.
R2-D2 —Beep, whee.
BIGGS: —Make haste, Luke. O, alas!
[Darth Vader shoots. Explosion. Biggs dies.
LUKE: That ever I should see this day, O woe!
My childhood friend from Tatooine now slain
Protecting me from harm. Thou ow'dst a life— 285
Dear Biggs, sweet Biggs—and thou hast paid. And now
'Tis down to me: the boy turn'd warrior.
Be still, my errant heart, and seek the Force.
VADER: The leader now is mine.
R2-D2: —Meep, beep.
C-3PO: —Take care
Sweet R2-D2! Come thou back, I pray! 290
CHORUS: Luke's ship comes closer to the little port
While Vader and his crew draw all too near.
Young Luke to his computer doth resort
Until he hears the voice speak in his ear.
Enter Ghost of Obi-Wan Kenobi.
GHOST: O use the Force, dear Luke. Let go and trust! 295
VADER: I sense the Force in this one here, almost
As if I did my younger self espy.
GHOST: I prithee, trust me, Luke. All shall be well.
LUKE: The hearing of these words is like a balm
Unto my soul. So shall I trust the Force 300
And not this fallible computer here.
[Luke turns off computer.
COMPUTER: What is this, Luke? Thy targeting machine
Hath been turn'd off. What can be wrong? Pray tell!
LUKE: Nay, all is well. Fear not, good friends.
R2-D:2 —Beep, squeak.
[Darth Vader shoots. R2-D2 is hit.
Ahh hoo!
LUKE: —Small R2-D2 hath been lost! 305
COMPUTER: The Death Star now has come within our range.
TARKIN: Commander, thou may'st fire when thou hast made
All goodly preparation thereunto.
VADER: Now face thy death, thou rebel.
PILOT: —Sir, take heed!
CHORUS: Now in a trice brave Han is on the scene! 310
The smuggler hath return'd on errand kind.
With sly approach he makes his way unseen
And slays th'Imperi'l pilots from behind.
[Enter Han Solo with Chewbacca, firing on
Darth Vader and Imperial Pilots. Explosion.
Imperial Pilots 1 and 2 die.
VADER: But how?—
[Darth Vader exits in confusion, his ship spinning
out of control.
HAN: —Thy path is clear, young Luke. Now do
Thy deed and let us all make way back home. 315
LUKE: I stretch my feelings out and use the Force,
And on the instant seems the porthole vast—
Not small or difficult to strike, but large.
The ship is arm'd, and now I take the chance—
The blast's away, and with it all our hopes! 320
[Luke shoots and hits the target.
CHORUS: The laser hits its mark with certain aim,
And as the Death Star arms to strike the base
The chain reaction sets the orb aflame:
The Death Star hath exploded into space.
HAN: Thy timely blast hath hit the perfect mark— 325
One in a million was thy Force-fill'd shot!
GHOST: Remember me, O Luke, remember me,
And ever shall the Force remain with thee.
Excerpted from the book WILLIAM SHAKESPEARE'S STAR WARS. Copyright © 2013 by Ian Doescher. Reprinted with permission of Quirk Books.
It's HERE AND NOW.
What if you took two cultural touchstones, both with devoted followings, and mash them together, say, Shakespeare and "Star Wars"?
DANNY DAUPHIN: (as Darth Vader) In time, thy powers have weak become, old man.
JON W SPARKS: (as Obi-Wan Kenobi) And yet thou canst not win, I'll warrant, Darth. For if thou strike me down, e'en now, e'en here, I shall more great and powerful become than e'er thou hast imagine possible.
HOBSON: That's a clip from the book trailer for "William Shakespeare's Star Wars: Verily, A New Hope." Ian Doescher is the author. The plot is pretty straightforward. It's "Star Wars Episode IV: A New Hope," the first of the "Star Wars" films to be released, written in Shakespearean English. Ian joins us from the studios of Oregon Public Broadcasting. And, Ian, where did this idea come from?
IAN DOESCHER: It was really a combination of events that happened last year. I read "Pride and Prejudice and Zombies," and I re-watched the "Star Wars" trilogy with a group of friends, then went to the Oregon Shakespeare Festival with my family. And it was while I was at the Oregon Shakespeare Festival that I sort of had this idea to combine "Star Wars" and Shakespeare.
HOBSON: All right. So just to give people a sense of what you're doing here, let's hear how things translate from the movie. This is the famous scene where Han, Luke, Leia and Chewbacca are being chased and shot at by Stormtroopers while they were trying to rescue Leia, and then they jumped into the rash compactor. Here is how it plays out in the movie.
HARRISON FORD: (as Han Solo) Let's get out of here. Get away from there.
MARK HAMILL: (as Luke Skywalker) No, wait.
HAMILL: (as Luke Skywalker) Will you forget it? I already tried it. It's magnetically sealed.
CARRIE FISHER: (as Princess Leia) Put that thing away. You're going to get us all killed.
FORD: (as Han Solo) Absolutely, your worship. Look, I had everything under control until you led us down here. You know, it's not going to take them long to figure out what happened to us.
FISHER: (as Princess Leia) It could be worse.
FORD: (as Han Solo) It's worse.
HOBSON: All right. So that's the scene from the movie, 1977, "A New Hope." Now, this is the trash compactor scene as you have rewritten it.
DOESCHER: (Reading) I'll blast the door. Swift get thee hence.
HOBSON: (Reading) Nay, prithee, shoot thou not.
HOBSON: (Reading) Thou arrant knave, wouldst thou undo us all? I have already tried to exit thus, but lo, as thou now plainly seest, thou brute, the passageway is sealed magnetically.
(Reading) Now rid us of that blaster, quickly too, else shall thine edgy trigger finger mean the certain death of all of us herein.
DOESCHER: (Reading) O, aye, thy Worship. Ha. 'Twas all in my control till thou'st didst lead us to this heap, nor shall the Stormtroopers need any time to calculate where all of us have flown.
YOUNG: (Reading) And yet, I say to you, it could be worse.
DOESCHER: (Reading) 'Tis worse. I'll warrant, something lives in here.
HOBSON: So how did you do that?
DOESCHER: I spent the better part of three months with the movie, going through sort of a minute or two at a time. And it was really almost like a translation job. Translating it into iambic pentameter and into something that at least sounds a little more like Shakespeare's idiom.
HOBSON: Were there things that were hard to translate that it just took you a while to figure out what exactly Shakespeare would say?
DOESCHER: The hardest things to translate have sort of become part of "Star Wars" lore, you know, things that I knew that people would be turning to first thing to see how I handled it. So things like whether or not Han shot Greedo first, for instance, that moment or things like Luke's sort of whiny line about going to Toshi Station to pick up power converters.
All of those things played on my mind heaviest because I knew that there are a lot of people out there who were going to be concerned about how I handled them.
HOBSON: Now, you're exploring two different worlds here that have fanatics, both of them. I mean, there are "Star Wars" fanatics who know everything about every episode of "Star Wars," and there are Shakespeare-ophiles who know everything about every work of William Shakespeare. Which did you find would be harder to please as you did this?
DOESCHER: I think the "Star Wars" fans probably have more sort of invested. I think it's easier for the people who love Shakespeare to sort of laugh and write this off although, ultimately, I hope that won't be the case once they take a look at it. It's the "Star Wars" fans who are going to, you know, call you bad names in the street, you know, for messing something up. They're the ones who are harder to please.
HOBSON: Now, for most of the book, you're rewriting the script in Elizabethan English, but sometimes you create these scenes that are Shakespearean. And I want to listen to one. This is an example of Luke Skywalker giving what feels like a riff on the Yorick speech from Hamlet. Let's listen.
ANDREW CRIGLER: (as Luke Skywalker) Alas, poor Stormtrooper, I knew ye not. Yet have I ta'en both uniform and life from thee. What manner of a man wert thou? A man of inf'nite jest or cruelty? A man with helpmate and children too? A man who hath his Empire serv'd with pride? A man, perhaps, who wish'd for perfect peace? Whate'er thou wert, good man, thy pardon grant unto the one who took thy place: e'en me.
HOBSON: So tell us about that.
DOESCHER: Visually, when we think about Shakespeare, the image that sort of culturally brings Shakespeare right to mind is a person standing there, holding a skull. And so I wanted to have that same scene, and it works really well into the storyline of "A New Hope" because there is that scene. Actually right after the trash compactor scene, they've been dressed up as Stormtroopers and then they're changing out of those clothes. And so it seemed a perfect time for Luke to sort of wax poetical about who the Stormtrooper might have been.
There are different references to Shakespeare throughout the book. Some of them are crystal clear. Some of them are just sort of using literary devices, but that, obviously, is a - it's a pretty clear one.
HOBSON: What do you think Shakespeare would make of what you've done?
DOESCHER: I think he would think it's fun emulation. I think he'd probably look at it and say, well, you know, don't quit your day job.
DOESCHER: He'd say, you're no Shakespeare. But I do think he would enjoy it. Shakespeare had a great sense of humor and I think would have enjoyed sort of the spirit behind this book and also just some of the ways in which I played with the movie.
HOBSON: Shakespeare is difficult for many people just to read and understand. You have to read it at a sort of slower pace than you would read anything else because the words are so different. Could you have picked another author that would have made it even more difficult for you to translate it?
DOESCHER: I suppose you could try Chaucer. I think Shakespeare in middle - I'm sorry - "Star Wars" in Middle English would be a lot more difficult than Shakespearean "Star Wars." There is this sort of idea in our culture that Shakespeare is hard to get into. And I think a lot of students actually come up against a brick wall mentally when they are about to be studying Shakespeare because they just assumed that they won't be able to get it because of the vocabulary, because of this weird thing called iambic pentameter, whatever that is.
I really ultimately hope that this book will maybe even help kids get into Shakespeare some. Maybe it'll be sort of a bridge by which they can get into Shakespeare, not be so intimated by Shakespeare. If they've been exposed to the meter, have been exposed at least to a little bit of the language and some of the devices that Shakespeare uses, then maybe it'll be easier when they move into "Romeo and Juliet" or "Hamlet" to follow along.
HOBSON: Ian Doescher is the author of "William Shakespeare's Star Wars: Verily, A New Hope." Ian, thank you so much.
DOESCHER: Thank you.
HOBSON: And now, because you deserve it, one last reading from "Verily, A New Hope." Here's Ian, reading his version of the opening text from the beginning of the movie.
DOESCHER: (Reading) It is a period of civil war. The spaceships of the rebels, striking swift from base unseen, have gain'd a vict'ry o'er the cruel Galactic Empire, now adrift. Amidst the battle, Rebel spies prevail'd and stole the plans to a space station vast, whose pow'rful beams will later be unveil'd and crush a planet: 'tis the DEATH STAR blast. Pursu'd by agents sinister and cold, now Princess Leia to her home doth flee, delivering plans and a new hope they hold: Of bringing the freedom to the galaxy. In time so long ago begins our play, in star-crossed galaxy far, far away.
HOBSON: And special thanks, Robin, to our HERE AND NOW players Jonathan Peck, Emiko Tamagawa and Jack Lepiarz.
YOUNG: You know, we haven't heard from the players since "Downton Abbey," the video game...
YOUNG: ...which was also completely ridiculous, and I bought it.
HOBSON: This is HERE AND NOW from NPR and WBUR Boston. I'm Jeremy Hobson.
YOUNG: I'm Robin Young. Transcript provided by NPR, Copyright NPR.

subset: commoncrawl


text:
Get your groove on with one of GigMasters authentic, eclectic world music bands. A talented world music artist can make your next event truly unforgettable. Search GigMasters today and find a one-of-a-kind world music band for your next party.
Copyright © 2018 GigMasters, Inc. All rights reserved.
Use of this site constitutes acceptance of the user agreement.


text:
Commerce Announces Final Grant Awards from First Funding Round
WASHINGTON, April 27, 2010 – The Commerce Department has announced nine broadband investments totaling more than $114 million in grants, in more than a dozen states. The announcement marks the final grant awards from the first round of BTOP applications. Keep Reading


text:
Meet thousands of Alhambra singles through one of the best Alhambra online dating sites. Matchmaker.com has great instant messenger and live video Alhambra chat service for our members. Alhambra dating has never been easier with our show interest feature that will allow you to break the ice with attractive local singles.
Matchmaker.com has some great services for Alhambra singles looking for a longer term relationship. Besides our great Alhambra chat product with live video matchmaker users can send email messages to people in the area. The Alhambra dating scene can be hard to find the right person at times; however, we are here to help and our Alhambra online dating service is free to register.
AlhambraJoin Now Free!
Alhambra Girls | Alhambra Men | Alhambra Gay | Alhambra Lesbians
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
More Alhambra Links:
Alhambra Personals | Alhambra Speed Dating | Alhambra Chat | Alhambra Singles | Alhambra Love
Senior Dating | Catholic Dating | Christian Dating | Muslim Dating
Black Singles | Asian Singles | Latin Dating
Try our Alhambra dating service today. Matchmaker.com is one of the oldest Alhambra online dating services on the Internet and has brought thousands of couples together from the area. Test drive our Alhambra Chat room with one of the best online communities for the Alhambra single person. Also, keep in mind that we have a huge member base of Alhambra singles and that we also cater to members of the many backgrounds.
Still not convinced that matchmaker is the free Alhambra dating service for you? Once you've filled out the quick registration process you will be to see full size photos and profiles of thousands of Alhambra singles. Did you know that free Alhambra dating is a few clicks away? Find love and romance in Alhambra at matchmaker today!


text:
Rose Ring
Regular price
This ring is a copy of a gold ring found during the excavation of the Rose Theatre on Bankside. The piece is engraved with the French inscription 'PENCES POVR MOYE DV'. The letters 'DV' stand for the Latin words 'Deo Volente' and the inscription translates as 'Think of me God willing'.
The ring is also decorated with a heart and two crossed arrows. Please note that the ring is a copy of a very old piece of jewellery and although the inside of the ring is perfectly round the outside has all the imperfections and markings of the original which adds to the piece's charm and history.
This ring makes a truly special gift for a loved one or for yourself and comes in a gift box with a brief history of the ring inside.
Available in Sterling Silver and Gold Plated Copper
Small (approx. 16mm diametre, UK size K, US size 5.5)
Medium (approx. 18mm diameter, UK size P, US size 8)
Large (approx. 20mm diametre, UK size U, US size 10.5)


text:
This take on Minted was made by
undefined from , a member of Minted's
community of independent artists.
Enjoy 15% off everything + FREE shipping year-round. JOIN MINTED MORE >
This Mother's Day show the mother in your life how much you love and appreciate her with a beautiful and unique gift of independent design. Personalized stationery is the perfect gift for any mom who loves to jot down notes or mail stunning correspondence. Choose from a selection of brilliant colors, style, shapes and flat or folded designs. Add your mother's name or initials to complete the look of her custom note cards.
At Minted we also have a stunning collection of non-stationery Mother's Day gifts that can both compliment your stationery choice, or stand on their own as a beautiful gift. Visit our favorite Mother's Day gifts to find stunning options and inspiration. From leather accessories for a chic on the go look, to cocktail napkins and custom art we have a style for every mother.
Accompany your selection with custom Mother's Day cards perfect for not only completing your gift, but for sending to all the mothers you know and love. Personalize your lovely sentiment with a photo, or many photos, and a Mother's Day greeting. Or select a non-photo stationery design and express your appreciation with the work of a Minted artist. No matter what you select, you cannot go wrong gifting independent design this Mother's Day.
We uncover design genius through ongoing design competitions. At
Minted, all that matters is good design. Designers submit, and the
Minted community votes to tell us what to sell.
"Our purpose in life is to uncover exceptional design from
all over the world and bring this to savvy consumers who won't
accept anything else."
Copyright © , MINTED LLC, all rights reserved


text:
Security and Privacy
are Your Rights!
CCP Inc. comprises a group of lawyers and sister companies, officially licensed as agents in all offshore jurisdictions offered. Count on us for professionally designed tax-advantaged solutions offshore!
In October, 2016 – CCP Inc. had acquired operations of the Offshore Company Incorporation Ltd. (OCI Ltd.) and will provide offshore company formation and maintenance services for former clients of OCI Ltd. at the same or better prices.
We accept:
Please check our low-cost Offshore Incorporation Prices for:
Peace of mind and security can be yours. Maximize profits with tax-sheltered trade and investment offshore corporations, while planning inheritance, succession and taxes with foundations and trusts. Unbeatable Prices and Experienced Service Guaranteed!
We have carefully chosen and established long-standing relations with banks in the Caribbean, Europe and USA and as a result you can have the best Offshore Bank Account options.
We also offer Offshore Bank Licensing services in Dominica.
CCP Inc. has more than 15 years of exceptionally successful experience working with Second Citizenship Programs.
We process applications for second citizenships by way of real estate and economic investments under robustly regulated programs. Each country offers two routes:
CCP Inc. is your Reliable Gateway to Second Citizenship, Offshore Banking Professional Offshore Foundation, Offshore Trust and Offshore Company Formation Services!
"All human beings have three lives: public, private and secret."


text:
Just as marketers are getting a handle on Facebook, Twitter, and YouTube, a fresh group of social media networks are poised to make a splash in 2010.
These networks have not reached mass adoption yet, so it's not necessary to get active on all of them immediately. But remember, Facebook only took 6 years to reach 400 million registered users. You should keep an eye on these five upstarts to see if their innovative services attract large audiences in the near future.
Why You Should Pay Attention
Learning the ropes on new services before they gain mass traction can help you get value from them faster once they catch on. Monitoring the innovations in the social media space also gives you an indication of how the market is changing and will evolve over the next few years. Marketers should stay abreast of broader market trends to assure their messages stay relevant.


text:
Daniel Franzese and Amanda Seyfried in Mean Girls. (Photo: Paramount/Courtesy Everett Collection)[/caption]
Of course, helping those affected by the Las Vegas massacre is the human, compassionate thing to do, but now it's the grool thing to do, too. Mean Girls cast members Amanda Seyfried, Lacey Chabert, Daniel Franzese, and Jonathan Bennett starred in a video released Tuesday, Oct. 3 — known as Mean Girls day, because the of the date's significance in the 2004 flick — asking fans to donate as little as $3 to the cause.
"Guys, look. We know fetch is never gonna happen," Chabert (aka Gretchen Wieners) says. "But we can make this happen."
The origins of Mean Girls Day, of course, stem from the scene in the movie in which Bennett's Aaron Samuels — the crush of Lindsay Lohan's Cady Heron — asks her for the date in class.
As of late Tuesday morning, the clever campaign, hosted at GoFundMe.com/october3, had raised nearly $10,000 of the $300,000 goal. Many of the donations were small, just $5 or $10, but more than 500 people donated. (Too bad the movie's star, Lindsay Lohan, has been out of the country, and missed the chance at a mini reunion, since she's long wanted a sequel. She marked the day with a meme.)
The message on the campaign website: "We are working directly with the National Compassion Fund, a program in the National Center for Victims of Crime. This organization collected and distributed funds to victims of the Pulse Nightclub shooting, the Aurora shooting, and even 9/11. 100% of funds raised will be distributed to the victims of Las Vegas through the NCF at the completion of this campaign."
And celebs in the Mean Girls crew weren't the only ones supporting victims. A separate GoFundMe page, organized by Clark County Commission Chair Steve Sisolak, collected more than $3.6 million from 51,000-plus people in its first day. Kid Rock was a big part of that; the rocker contributed $10,000, as did the bands Florida Georgia Line and The Chainsmokers, and Vegas mainstay Mike Tyson. Today show host Hoda Kotb kicked in another $1,000.
Read more from Yahoo Lifestyle:
- 'I got just one life': 8 Tom Petty quotes that'll inspire you to seize every moment
- Why the federal 20-week abortion ban is up for a vote — again
- Full screen fever: Tom Petty's most iconic music video moments
Follow us on Instagram, Facebook, and Twitter for nonstop inspiration delivered fresh to your feed, every day.


text:
No, but not everyone here is willing to engage in quite your level of pants-shitting before the season has even begun. We may be the same, we may be improved, we may be a disaster in waiting. Who the heck knows? You don't. I don't.Rumsfeld wrote:Holy crap, you'd think this was the website for the Chicago Blackhawks based on the doe-eyed optimism and complete refusal to criticize core players or management decisions.
I get that this is a hockey chat board and a place to exchange opinions. I just don't get how married folks here get to their own personal prediction of the future. You don't own a crystal ball.


text:
If one ever doubts that full moons somehow have the ability to create bizarre or strange occurrences, look no further than Sunday night's Coca-Cola 600 at Charlotte Motor Speedway.
If one ever doubts that full moons somehow have the ability to create bizarre or strange occurrences, look no further than Sunday night's Coca-Cola 600 at Charlotte Motor Speedway.
On lap 121 of the 400-lap race on the 1.5-mile track, one end of a drive line on a FOX Sports camera high above fell from the grandstands and landed on the racing surface. That meant the long loose apparatus was right in the path of third-place Kyle Busch, who hit it head on at 180 miles per hour and sent it flying.
NASCAR red flagged the race for 27 minutes and allowed teams to repair their cars.
As one end broke loose and dangled, the rope acted as a whip of sorts with part of it being thrust into the grandstands. Ten fans suffered cuts and bruises from being struck by or dodging the wild snake-like cord. Thankfully, all those injured were treated and released in the infield care center or a nearby hospital.
Fox Sports released a statement Sunday night saying it hasn't determined why it broke loose. Company officials were sincerely concerned for those injured and for disrupting the race.
"At this time, we do not have a cause for the failure of the camera drive line that interrupted tonight's Coca Cola 600 at Charlotte Motor Speedway, and our immediate concern is with the injured fans," the statement said. "The camera system consists of three ropes — a drive rope which moves the camera back and forth, and two guide ropes on either side. The drive rope failed near the Turn 1 connection and fell to the track. The camera itself did not come down because guide ropes acted as designed. A full investigation is planned, and use of the camera is suspended indefinitely.
"This camera system had been used successfully at this year's Daytona 500, last week's NASCAR Sprint All-Star Race and other major events around the world. We certainly regret that the system failure affected tonight's event, we apologize to the racers whose cars were damaged, and our immediate concern is for the race fans. We also offer a sincere 'thank you' to the staff at CMS for attending to the injuries and keeping us informed on this developing situation. When we have more information on the cause of the equipment failure, we will share it with you immediately."
Drivers parked on pit road for 27 minutes while crews repaired damage to their cars. Many received damage enough to eliminate their chances for the win.
Busch received the most damage at the front of his car but eventually fell out with a bad engine on lap 253. Busch thanked NASCAR for allowing all teams a 15-minite period to fix their cars.
"I just heard a big thunk on the right-front side tire and thought the right-front tire blew out,'' Busch said. "That's how hard it felt. ... It did have an effect slowing my car down and I could feel it like, 'Whoa, that's weird.' I don't know that anybody has ever seen that. Maybe now we can get rid of that thing."
Kasey Kahne said he thought his eyes were playing tricks on him when he saw something strange on the track.
"I have never seen anything like it," Kahne said. "I came off turn four and I saw it wrapped around Kyle's car and it hit mine and I thought I had to be seeing things because there's no way there could be a cable on the race track. By the time we got to turn one I saw it again and saw Kyle's fender and saw his car go down a little. That's when I knew I wasn't seeing things."
Marcos Ambrose suffered massive damage to his Richard Petty Motorsports Ford when the nylon wrapped around the rear end housing.
"It was like getting attacked by a giant squid," Ambrose said. "It was just flapping and I didn't know what was going on. I thought it was cords coming out of maybe one of (Mark Martin's) tires or something, but I could just hear it flapping. And then it got caught up in the rear end and I lost my brakes, so it was a nightmare but we got through it.
"NASCAR did a great job of actually handling a crisis there because we were hard-done by and they gave us our laps back and we were able to stay in the race and duke it out."
Kevin Harvick, a driver for Welcome's RCR Enterprises, won his second race of the season and second-career 600 win at Charlotte. He discovered Sunday night's race was a matter of first surviving the weird and unthinkable before entertaining any ideas of racing for the win.
Ben White is a motorsports columnist for The Dispatch.


text:
NEW YORK–Can training really make corporate cultures dominated by white men more inclusive? For years, critics have debated its impact, but a new Catalyst study with employees of the global engineering company Rockwell Automation, Calling All White Men: Can Training Help Create Inclusive Workplaces? shows training can produce a measurable shift in workplace attitudes and behavior—and begin to create an environment where women and minorities can advance.
Catalyst surveyed Rockwell employees—mostly white male managers—who participated in leadership development programs run by the organization White Men as Full Diversity Partners. In an industry dominated by white men, Rockwell hoped the programs would equip and inspire its white male employees to play a more central leadership role in creating an inclusive work environment.
The study supports Catalyst's belief in the importance of engaging men as champions of gender diversity. Catalyst recently launched MARC—Men Advocating Real Change—an online learning community for professionals committed to achieving gender equality in the workplace.
Key findings of the Catalyst study include:
An increase in workplace civility and decline in gossip (e.g., snide remarks and behind-the-back comments). In some workgroups, participants' colleagues rated the incidence of workplace gossip as much as 39 percent lower after the labs, signaling improved communication and respect.
Managers were more likely to acknowledge that inequities exist. After the labs, there was a 17 percent increase in how much managers agreed that white men have greater advantages than women and racial/ethnic minorities.
Managers improved on five key behaviors for inclusion. From seeking out varied perspectives to becoming more direct in addressing emotionally charged matters, managers improved on critical skills for leading in today's diverse marketplace.
Having cross-racial friendships mattered. Managers without many prior cross-racial relationships changed the most after the labs when it came to thinking critically about different social groups—a 40 percent increase in ratings vs. a 9 percent increase for those with more of these relationships.
Those who cared the least about exhibiting prejudice changed the most. After the labs, managers who initially were the least concerned about appearing prejudiced were the ones who registered the most significant change in taking personal responsibility for being inclusive, as evidenced by a 15 percent increase in ratings.
"Companies can see a major shift in inclusive behavior when white men acknowledge inequalities and accept that while they didn't cause the problem, it's their responsibility as leaders to be part of the solution," said Ilene H. Lang, President & CEO of Catalyst. "We can't rely only on women and minorities to advocate for culture change. The results are much more powerful when white men, who are most often in leadership positions, are also role models."
For information on the study's methodology, visit Calling All White Men: Can Training Help Create Inclusive Workplaces?.
For a video introduction, please click here.
Interviews available.
Founded in 1962, Catalyst is the leading nonprofit membership organization expanding opportunities for women and business. With offices in the United States, Canada, Europe, and India, and more than 500 preeminent corporations as members, Catalyst is the trusted resource for research, information, and advice about women at work. Catalyst annually honors exemplary organizational initiatives that promote women's advancement with the Catalyst Award.


text:
STUART KIDMAN learns about the many ways up Snowdon and gives one of the lesser-travelled routes a try
Someone once told me there are 100 ways to climb Snowdon.
* Compared to two non-member adults sharing a pitch
†Based on the assumption that both members have accredited age concession. ACR is available on pitch fees in all seasons except high season
Back to top


text:
The Office Platform Team released two new Microsoft Office 2010 Accessibility Add-ins on March 17th. While comparatively small add-ins, they enable big things! Try them yourself by downloading via the below links.
The Subtitling Add-in for Microsoft PowerPoint (STAMP)helps Microsoft PowerPoint 2010 users add closed captions to the video and audio files included in their presentations, which boosts their impact for those with hearing disabilities. This also enables video and audio in PowerPoint to be localized in different languages.
The DAISY Consortium, Save as DAISY for Office 2010 helps Microsoft Word users convert Word Open XML files to the Digital Accessible Information System (DAISY) format, which powers digital talking books and compatible software & braille readers for this with print disabilities. This version now supports Office 2003, 2007 and 2010.
To get a full picture of all the Office 2010 Accessibility features, you can do here


text:
Please let us know if you have suggested content to add, and visit later to see how the page develops. Send your contributions and comments to us here...
3D Archaeology Sites and Virtual Tours
Interactive Web Sites for Kids
On-a-Slant Virtual Mandan Village Game
This game involves 3D reconstructions of a Mandan Village located on the ground of the Fort Abraham Lincoln State Park in North Dakota. It is based on scholarly research of the site, the native population, and the era (circa 1776-1781). It was created by the North Dakota State University Archeology Technologies Laboratory (ATL). The downloadable game runs via the Java Web Start delivery system. By using webstart, the WWWIC is able to provide quick internet updates to the software every time you use the program.Webstart is part of the Java JRE installation, and version 1.5 or higher is required for the On-A-Slant Virtual Village client. Includes link for an Install/upgrade of Java 1.5.
RealArcade is an online gaming site. It has a lot of fun games with archaeology characters and archaeology themes. Archaeologist and Blogger Anita Cohen-Williams says, "the games I enjoy are Jewel Quest, Jewel Quest Solitare (both of these are about Mayan lost citiies), 7 Wonders (of the World), Acropolis (word game), Luxor Mahjong, Scarabs of Pharaoh, The Legend of El Dorado, Treasures of Montezuma, Zuma, and many others with ancient themes".
Eternal Egypt: Solve the Stela (Field Museum, Chicago, Illinois)
Cleopatra: Solve the Puzzle (Field Museum, Chicago, Illinois)
Mystery of the Bones Exploration (digNubia- Exploring the Science of Archaeology)
In this exploration, you will learn how to determine sex based on skull characteristics and height based on femur length. What else can you learn by examining skeletal remains?
Where am I? [Global Positioning and Archaeology Sites] (digNubia- Exploring the Science of Archaeology)
The Global Positioning System (GPS) is a system of 24 satellites that orbit the Earth. This 'tool' is especially useful to locate archaeological sites.
How do we known when? The Technique of Seriation (digNubia- Exploring the Science of Archaeology)
Learn about the Seriation which is a technique archaeologists use to figure out how old an archaeology site is.
How do we Excavate? Plan an Excavation (digNubia- Exploring the Science of Archaeology)
In this game, you are the archaeologist -- you decide what tools to buy, which experts to hire, and how to dig. This excavation simulation game was developed by Learning Sites for the digNubia- Exploring the Science of Archaeology project.
Updated 04/04/2007


text:
You are here
Home » Overview » Exhibitions
Unlikely Angel: Dwight Ripley & the New York School
On view February 9 through March 18, 2006
A rare glimpse into the archives of Dwight Ripley, little-known figure behind the pivotal Tibor de Nagy Gallery.
Showplace for New York School painters, the gallery also published a series of chapbooks by many of those who later became known as the New York School of Poets. Among the items on display are John Ashbery's first book, Turandot; a rare copy of Frank O'Hara's Oranges (original cover by Grace Hartigan); a painting by Helen Frankenthaler; and samples of Ripley's own drawings.
Curated by Douglas Crase
Date and Time:
Thursday, February 2, 2006 (All day) to Saturday, March 18, 2006 (All day)


text:
Washed Away
Menacing waves left us clinging to the boat as we made our way towards the reef.
Despite roughly bobbing on the waves and dreading the thought of dispelling the contents of our tummies in the most unflattering way, everyone was high spirited and laughter rocked the boat even more. The enthusiasm of witnessing these ancient creatures had gripped us.
And as anticipated, lo and behold, we came across four on the surface close to a seagrass bed near the island.
Adding to the excitement was the prospect of finding nesting sites on Yadua Island.
Much to our disappointment, the reality of the absence of nesting sites was hard to stomach. A key nesting site where the turtle monitors (DauniVonu) had tagged a nesting Hawksbill turtle, had been washed away, leaving an impenetrable bedrock along the beach and a steep terrain close to the vegetation zone.
"The nesting turtles find it hard to even find a place to nest, as this beach is gradually being washed away," said Pita Qarau, a DauniVonu from Yadua.
On another nesting beach on the island sanctuary of YaduaTaba, a nest we inspected had been inundated with 100% unsuccessful eggs. "There go 145 baby turtles," were the first words of Barry Hill, another DauniVonu from Yadua, resounding the sinking sentiments shared by the team.
The plight of sea turtles in Fiji is not only attributed to its high exploitation, but also because of natural occurrences. These situations have encouraged us to address these impacts even more. The WWF South Pacific Programme Office has been working very closely with the Department of Fisheries, to make ammendments to the Turtle Moratorium to make provisions for the relocation of vulnerable nests.
The Dau Ni Vonu's will also require special training in relocating the nests keeping in mind the need for properly handling turtle eggs and choosing appropriate sites to relocate these nests to.
Collaborations on a communal level, as well as a more unified approach in trying to save these species can ensure these ancient, gentle creatures continue to return to these nesting sites in years to come.
Written by Thomas Tui, the Marine Species Coordinators at WWF South Pacific


text:
SHELBY COUNTY, TX (KTRE) - An earthquake of moderate magnitude was detected in Shelby County early Friday morning, according to the U.S. Geological Survey.
Seismometers detected a 4.1 magnitude temblor around 1:01 a.m., about 2 miles west of Timpson.
"It looks like now that this is going to be the norm for us," Sharon Hamilton, a Huber resident, said Friday.
For Hamilton, time seemed to stand still. She said at 1:04 a.m., she felt an intense shaking and heard a loud crash.
"My whole bed was trembling, my whole floor and everything," Hamilton said.
As a result of the shaking, a weight fell, shattering the bottom of Hamilton's grandfather clock.
Larry Burnes, Timpson's emergency management coordinator, said even though last night's quake wasn't the strongest in the last year in the last year and a half, it lasted the longest.
"Probably 30 to 40 seconds maybe a minute, one of the charts that I pulled the information off of showed it about a minute long," Burnes said.
After the quake, Burnes drove through town looking for major damage.
John Spinuzzi, who owns a business in downtown Timpson called Remote World Computer, says the unexpected quakes are affecting his building.
"Every time we have an earthquake the crack gets a little wider," Spinuzzi said.
Spinuzzi said the building was built in the 1900s, and the lateral motion of last night's quake shifted the brick about half an inch.
"When I got up on my feet the house was moving back and forth," Spinuzzi said.
So now, there's more anxiety as folks in the Timpson area wonder when the next earthquake will shake their foundations.
The USGS reported the tremor's depth was measured about 4 kilometers below the surface of the Earth.
The Shelby County and Rusk County Sheriff's offices confirm no injuries have been reported. Homeowners reported minor cracks in drywall and a dollar store in Timpson was cleaning a mess after merchandise fell from shelves, according to Sheriff's officials.
Viewers from Mount Enterprise, Center, and Garrison to Shreveport reported feeling the shaking. Sheila Hardey, of Mount Enterprise, said she felt the quake for at least 10 seconds. "It was scary honestly. I was like oh my gosh is my house going to collapse? Because I live in a trailer house and I was like is it going to move off the foundation? I was in the chair and my kitchen chair was moving me back and forth."
Friday's tremor follows a weaker 2.8 magnitude earthquake reported in the same area in December. Seven quakes have been detected in the region since May 2012.
•May 10, 2012 - (3.9) NW of Timpson.
•May 17, 2012 - (4.8) ENE of Timpson.
•May 20, 2012 - (2.7) SSW of Timpson.
•May 26, 2012 - (2.5) SE of Timpson.
•June 16, 2012 - (2.1) SSW of Timpson.
•December 7, 2012 - (2.8) SW of Timpson.
•January 25, 2013 - (4.1) W of Timpson.
The Texas State Historical Association cites a 80-kilometer segment of the Mount Enterprise fault system which caused earthquakes in 1891 and 1981, in Rusk and Center and Jacksonville, respectively.
Another series of moderate earthquakes hit Sabine County on April 23, 1964. According to the USGS, Hemphill was near the epicenter of the 4.4 magnitude earthquake. Aftershocks were reported in Pineland, Hemphill, and Milam. Cracked wallpaper and plaster were the only damage reported. More tremors, reaching 4.2 in magnitude, were reported in May, June, and August of that year.
In 1957, several shocks were reported at 4.7 in magnitude in the Gladewater area in Northeast Texas.
You can receive instant alerts about earthquakes in East Texas by downloading our StormTracker Weather app, free for iPhone, Android, and iPad. For existing users, check the "earthquake" selection in the settings tab.
Copyright 2013 KTRE. All rights reserved


text:
Midyear Joins - Long Version
RENEWALS – PROCESSING PAYMENTS WITH " MID YEAR JOIN" - Long Version
(this selection is located in the "create invoice" screen under the billing tab at bottom of main screen and is used when a member is adding a division/section/round table to an existing record where the basic dues were previously paid)
Open the XTENDER and put a check in the box to the left of the item(s) being added to the current record. Go to CREATE INVOICE , select NEW, RENEWALS and scroll down to MID YEAR JOIN (no ALA dues) then click on RUN. System will bill the correct amount of dues according to the member type.
Go to the PAYMENT screen and enter the payment for the item being added. Don't forget to double click on the free items with the asterisk if it is applicable at this time. Make sure the expiration date of the new item matches the ALA expiration date.
There is a great possibility that you might have to manually change this date because the system will give it a date to match the cash batch date instead of the membership renewal date. EX: Member with 12/08 expiration adding YALSA for the first time to their record in a June batch will automatically be given an expiration date of 5/31/09 for YALSA.
To manually change this date to match the ALA expiration date; put the cursor in the "paid thru" box in the middle of the screen, enter the correct expiration date 12/31/08. The system will open a box at the top of the screen with the following prompt "adjust effective date/or a renewal month 06/01/08 change date to 12/31/08 and the effective date will change to 01/01/08 (which is the correct start date for a December item) Click on SAVE.
Go to ACTIVITIES at the bottom of the screen, double click to the left of the BASIC DUES category for the current year, select EDIT and remove the "card sent" date. (removing the card sent date must be done every time a member is adding something to an existing current record so they will get an updated membership card. This does not have to be done when a person is paying their basic dues because the system automatically prints a card for every record processed that included a basic dues payment.
Eap 5/28/08


text:
APEC Certificate Program for undergraduates and high school studentsUniversity of Hawaiʻi at Mānoa
Posted: Mar 9, 2011
Under the banner of Advancing Asia-Pacific, and in advance of Honolulu's hosting of the Asia-Pacific Economic Cooperation (APEC) summit in November 2011, University of Hawai'i at Mānoa Summer Sessions, administered by Outreach College, presents the APEC Certificate for Undergraduate Students and the APEC Certificate for High School Students. Completion of the certificate program will provide students with an advanced understanding of international issues and relationships specific to Asia-Pacific, and provide benefits for further educational goals and future employment. APPLICATIONS ARE NOW BEING ACCEPTED. For further information, including how to apply, visit www.outreach.hawaii.edu/summer or call 956-2026.
The APEC Certificate Program is intended for students interested in international relations, geopolitics, political science, economics, business, ethnic studies, the environment, and leadership, and provides a multi-faceted approach to understanding the issues and challenges facing the Asia-Pacific region. The Certificates combine college courses with lectures, films and opportunities for interaction with distinguished faculty and experts to provide a rich and unique learning experience. Certificates will be issued by the University of Hawai'i APEC Study Center.
In advance of Honolulu's hosting of the Asia-Pacific Economic Cooperation (APEC) summit in November 2011, University of Hawai'i at Mānoa Summer Sessions, administered by Outreach College, plans an array of programs focusing on the region's potential for peaceful, inclusive and sustainable growth.
Drawing from the diverse resources of the university and community, Outreach College presents a dynamic summer of lectures, films, performances, noncredit workshops, and certificate programs for high school and university students. These programs will provide venues for learning about the issues, discussing a wide variety of viewpoints, and cooperating toward greater international understanding.


text:
Kadell Womens Large Capacity Matte PU Leather Tote Handbags Purse Shoulder Satchel BagsSilver Silver -
?TOP MATERIAL? PU Leather Handbag with durable polyester lining and gold-colored hardware.
?FASHION DESIGN? This shoulder bag contains 1 main zipper section compartment, 1 inner zipper pockets and 2 small pockets, 1 outside zipper pockets. [Dimensions](L)13.38\" x (W)4.72\"x (H)9.45\" ; Shoulder belt: 22.05\"
?LARGE CAPACITY? Elegant design. It can easily hold your iPad mobile phones, wallets, cosmetics, sunglasses and any other small necessities, keeping all of them neat and clean.
?MULTIFUNCTION? Suitable for females of all ages on any occasions, including working, shopping, traveling and meeting.
?ATTENTION? Kadell is an US Registered Trademark and our ONLY Authorized dealer is Helresk. Please pay attention to avoid purchasing those COUNTERFEITS from other sellers, 100% genuine guarantee from Helresk. Unauthorized sale without permission.


text:
The U.S. Comex gold futures fell 1% on Thursday, ending at $1,669.90. During the early Asian hours on Friday, the gold futures have dipped a further 0.2%. While the gold futures dropped 1.01% this week, the S&P 500 index and the Euro Stoxx 50 index rose 0.59% and 0.49% respectively. The Dollar index touched 80 again on Thursday while ending the day at 79.949. For the week, the Dollar Index actually fell 0.11%.
Gold Ran into Resistances
The gold futures shot up to a recent high of $1,697.80 on Jan. 17 during New York hours, but are now trading 1.64% below that level. Several reasons are offered for the weakness. First, on Jan. 23, the U.S. House voted on suspending the debt ceiling until May. The Bill is expected to be passed by the Senate in late January, and approved by President Obama. Once the borrowing limit is raised, gold price will likely resume its climb due to further fiscal spending by the government. The rise in the December leading indicators in the U.S., and the higher January PMI data than the previous month in the Euro-area, China and the U.S. lead to expectations of stronger growth and higher real interest rates, therefore hampering gold prices. On Thursday, gold also fell in response to the lower U.S. initial jobless claims, which fell by 5,000 to 330,000. The gold market has been sensitive to any news suggesting an earlier-than-expected end to the Fed's quantitative easing.
Some traders believed that gold price fell because speculators liquidated their long positions when they saw that gold price could not break $1,700. The CFTC gold net non-commercial combined positions, as reported by Bloomberg, are still about 48% lower than the latest peak reached on Aug. 2, 2011, indicating the positions are not that crowded.
What We are Watching Next Week
Important data to watch will include the U.S. durable goods orders on Jan. 28, the U.S. FOMC interest rate decision and the U.S. preliminary Q4 GDP estimate on Jan. 30, Germany's January unemployment change on Jan. 31, and the Euro-17 January unemployment rate and the January U.S. non-farm payrolls on Feb. 1.


text:
Some features of this site are not compatible with your browser. Install Opera Mini to better experience this site.
|by Annette Varani
1996 was a record year for tropical cyclones. Of 43 such storms, 20 intensified to typhoons, and six more to super-typhoons. The storms levy lasting devastation, claiming lives, inflicting injuries and causing millions of dollars in property damages.
(Image courtesy of NASA) Typhoon Violet, on September 20, 1996, taken by the crew of STS-79.
NSCAT measures near-surface wind speed and direction over Earth's oceans at high resolution. Winds over the oceans are retrieved because the water's surface roughens rapidly with increasing wind speed, which increases the backscatter detected by this specialized radar instrument. NSCAT scans two 600 km bands of the Earth one band on each side of the instrument's orbit path, separated by a gap of 330 km. The instrument also provides data over land and ice surfaces under all weather conditions. NSCAT ocean wind products are available from the Jet Propulsion Laboratory (JPL) Physical Oceanography DAAC (PO.DAAC).
NSCAT wind speed and pseudo streamlines for June 24 through June 26, 1997. (Image courtesy of NASA Jet Propulsion Laboratory) Click here for full image (101kb)
Typhoon Olga winds viewed by SeaWinds August 9, 1999. (Image by Liu, Tang, & Xie, NASA Jet Propulsion Laboratory) Click here for more information
For more information, visit the Jet Propulsion Laboratory DAAC (now named the Physical Oceanography DAAC) and the NSCAT Home Page. (A new browser window will open.)
Also see the QuikSCAT Fact Sheet
Tropical cyclones with maximum sustained surface winds less than 39 mph are called "tropical depressions." Once a tropical cyclone attains winds of at least 39 mph, it is designated a "tropical storm" and assigned a name. If winds reach 74 mph, the storm is called a "hurricane" or, in the Northwest Pacific Ocean west of the dateline, a "typhoon." Typhoons that reach sustained surface winds of 150 mph are known as "super-typhoons."
For instance, September 22, 1996, Typhoon Violet slammed Tokyo with winds up to 78 miles per hour. Deluged by ten inches of rain in 24 hours, train, air and ferry services shut down. According to news reports, at least 80 landslides resulted from the flooding, and wind and mud combined to take three lives. Another 28 people were injured in the storm, 41 homes were destroyed, and more than 2,000 homes were flooded.
Typhoon Tom was born in the tropical Pacific at the same time as Violet. But instead of making landfall, Tom engulfed a low pressure system, became a mid-latitude storm carrying gale-force winds and proceeded out across the most well-trafficked of Pacific shipping lanes.
Although over the last decade reasonably accurate numerical weather prediction models have been developed to forecast typhoon movement, the models' predictive abilities are only as good as the input data. "We don't know much about typhoons, and we know even less about the thermodynamics during a typhoon's transition into a mid-latitude storm, because essentially we don't have data," said Timothy Liu, NASA Scatterometer (NSCAT) project scientist and team leader of the Air-Sea Interaction and Climate group at the Jet Propulsion Laboratory.
Mid-latitude storms, which meteorologists generally call "extratropical cyclones" or more simply, "lows," form through very different processes than hurricanes and typhoons. However, as typhoons and hurricanes leave the tropics and enter the westerly wind belt, they often change their character and evolve into strong mid-latitude storms. Understanding this dynamic requires data on wind currents.
Wind observations are usually made by merchant ships, Liu said, "but nobody goes to measure a typhoon in the ocean." Satellite imagery may help to locate storms, but do not reveal surface intensity, he said. Models are similarly inadequate.
"Simulations by numerical models do not help our understanding significantly because the models do not have the right physics or sufficient resolution," Liu said. "Yet mid-latitude storms resulting from typhoons usually have gale-force winds and heavy precipitation. Storm transition is a fascinating science problem, with important economic consequences. Transitions occur over the busiest trans-ocean shipping lanes, and if resulting storms ever hit land, they usually devastate populated areas."
Launched aboard the Japanese ADEOS satellite in August 1996, the scatterometer takes 190,000 wind measurements each day, mapping more than 90 percent of the world's ice-free oceans every two days. The instrument is expected to provide more than 100 times the amount of ocean wind information currently available from ship reports. A radar instrument, the scatterometer is capable of taking data day or night, regardless of sunlight or weather conditions.
NSCAT was activated on September 15. In October, data from the scatterometer began to pour in. The early images clearly displayed Typhoons Tom and Violet. The scientific community at NASA was elated at the prospect of using NSCAT data to possibly save human lives or mitigate potential disasters.
To learn about the typhoons' growth process and thermodynamics, Liu said, "we combined data from two different DAACs to show the relationship between the dynamics, which is the wind, and the thermodynamics, the moisture, which is given by the water vapor."
Applying the NSCAT wind vectors to the SSM/I precipitable water color image was particularly revealing of the physics in action, Liu said. "You can see Violet, just before it hits Japan, changing. Shear and frontal systems develop, dry air enters the picture. Similarly with Tom, you can see the storm's evolution very well."
Liu expects NSCAT winds, with their high spatial resolution, when combined with SSM/I precipitable water measurements, to improve storm diagnostics, vorticity, divergence, heat sources, and moisture sinks, without which it's hard to know, for instance, whether a typhoon will continue straight ahead and strike land, or whether a low pressure trough is present to send it back out to sea. Will a storm continue as a typhoon, or will it gather force and evolve into an even more dangerous system?
The next step for Liu's team is quantitative analyses. "With NSCAT winds and other satellite data, we can develop physical parameters to describe the thermodynamic transitions and calculate the convergence and heat balance to try to understand what happens in the storm transitions," he said.


text:
Guillermo Calderon was born in Mexico City in 1983. As a son of two pilots, he enjoyed taking pictures while traveling and began earning money from photography since he was 16. He started teaching photography to kids when he was 18 and gives at least one workshop a year since then. In 2003 he purchased his first DSLR and never returned to film, he indeed, never looked back at the pictures he had made with film.
He loves to photograph people. In 2009 started Nunu Bodas a Wedding and Portrait Photography studio, which was named in several occasions as one of the Top Choices for Wedding Photography and Video in Mexico City. Meanwhile, he has done a bunch of personal photography projects, including 230 shoots of different people on a bathtub, and many portraits of people he had just met.
Since switching to FUJIFILM entirely in 2015, Guillermo left the Wedding business, and began doing photography solely as a hobby, he is an amateur again. He is now capturing his moments in life, those Little pieces that where lost while making memories for other people.
Since his first years with a camera, he seeks for simple shapes and composition. Portraying defined elements in which light has the staring role.
When I first discovered the Fujifilm X-Series, I felt I had "less machine" between me and my subject. I didn´t care if people saw me with a camera or reacted to it, but then again the equipment felt less intrusive… to me. At that time, most of my work was in wedding photography, and as we know, the X-Series are praised for their small size and weight. So just as other photographers, my body thanked I ditched some kilograms in equipment.
Fujifilm's X-Series made me go out again and look for new shots. For me, photography is about giving order to the world out there, and the X-Series translates that world better than any other camera before did.


text:
Gisele Bundchen swung by Terry Richardson's studio recently for a quick photo sesh and here is a look at the Brazilian beauty as captured by the photographer. She's looking great as usual keeping it simple here sporting a white tee. Of course, the token "______ as me" photo was captured, too. Check out the snaps in our gallery.
- Source: terrys diary


text:
March 23. 2013 9:36PM
Dave D'Onofrio's Sox Beat: Buchholz is key for Red Sox
By DAVE D'ONOFRIO
Boston Red Sox starting pitcher Clay Buchholz throws in the first inning during a March 7 spring training game against the Minnesota Twins at Hammond Stadium. (Steve Mitchell-USA TODAY Sports)
Red Sox fans were so eager to put a woeful season in the past, and rightfully so, they probably weren't paying much attention this winter when Clay Buchholz was named the club's pitcher of the year for 2012.
It was an award that seemed to distinguish the right-hander only as the best of a bad lot, really. Buchholz finished with a record of 11-8, posting a 4.56 earned run average, and striking out only six batters per nine innings, while opponents managed a .757 on-base plus slugging against him. His numbers were all average, or below-average, so that he was deemed the ace of the staff presents a primary reason explaining why the team finished in the basement of the American League East.
Though look not at the sum, but rather the parts, and you'll also find reasons to think Buchholz could be key to a Red Sox resurgence in 2013.
Remember, at the start of last season he was historically bad. He allowed seven runs over four innings in his first outing, and it didn't get better for more than a month, as he was charged with at least five earned runs in each of his first six starts. He was the first pitcher in major league history to open a year that poorly, and his 33 were the most earned runs allowed by a Sox pitcher over his first six appearances in at least a century.
When Buchholz left the mound after yielding seven hits, four walks and five runs in 3 2/3 innings against the Orioles on May 6, his ERA stood at 9.09 - and there were legitimate questions about whether his next start would be in the big leagues. Or at least when it would come. There was speculation that if Buchholz wasn't actually hurt, the Red Sox might say he was in order to press the reset button and let him try to figure things out with some rehab starts in the minors.
Things didn't get that far. Though things didn't turn around instantly, either. Three starts later, his ERA was still 7.84, and opponents were hitting .330 against him with a .954 OPS.
But then came the correction. And cause for optimism this year.
Beginning with seven quality innings on May 27, Buchholz - who to that point could barely make it through surrendering five runs - allowed that many over his next four outings combined. Included therein was a four-hit shutout of the same Orioles team that had bounced him in the fourth inning just a month earlier, and that stretch proved a springboard.
Over his next 19 starts, Buchholz's ERA was 2.93, while foes hit just .229 with a .644 OPS against him. Eleven times he allowed two earned runs or fewer, eight of which were games in which he was charged with one or no runs. Fifteen times over that stretch he completed at least seven innings.
And what might be most encouraging moving forward is the evidence that he could've been even better. Just as he started to find his groove, he was hospitalized with internal bleeding from esophagitis and spent almost a month on the disabled list. Then there were a few more hiccups in his performance, as he was roughed up for five innings by the Marlins, seven runs by the Angels, and eight runs by the Yankees in a dreadful season finale where he recorded only four outs while allowing three home runs.
Ultimately that disaster of a finish, combined with his dreadful start, left his numbers looking wholly mediocre. Though for the better part of the three months in the middle, Buchholz was indeed the Red Sox' best pitcher - and, in fact, he was one of the best pitchers in the American League. He looked like the guy who just two seasons earlier had posted the AL's second-best ERA (2.33) and carried legitimate Cy Young hopes into September.
He looked like the pitcher the Sox have long expected him to be. And he looked like the pitcher who, at 28, could be the difference between them contending and them merely getting back to mediocre this season.
Ryan Dempster throws enough strikes and eats enough innings to think he'll be serviceable as Boston's No. 3 starter. If healthy, and seemingly so, John Lackey and Felix Doubront are capable in the Nos. 4 and 5 roles. And based on his career record and reunion with now-manager John Farrell, it's reasonable to think Jon Lester will bounce back and regain his status as the ace after what so far seems a brutal aberration.
But it's tough to contend with one top-tier stud followed by serviceable arms. Good teams have at least two good starters, so if Buchholz can fit that bill there's a decent chance the Sox could legitimately reenter the mix in the up-for-the-taking AL East - and at this point in his career, good should be a minimum expectation for Buchholz.
He's been that in the past, he was that for the majority of last season, and he's been that this spring. Entering Saturday's start against the Pirates and North Conway's Jeff Locke, he had allowed just a single run, and more importantly a hamstring strain sustained early in camp has proven no issue.
On Saturday, Buchholz threw 88 pitches over 5 1/3 innings, allowing just one run as Pittsburgh beat the Red Sox, 5-3.
Pirates' starter Jeff Locke of Conway, N.H., allowed three runs in four innings and retired the last six batters he faced.
Buchholz's results are encouraging in part because last year he struggled his way to a 5.23 ERA over spring training - and it's not a reach to say that slump bled into the regular season, or that it was a precursor to his pitiful start. A solid March this year doesn't necessarily mean his April will be any better, but the longer it lasts the clearer it becomes that he figured something out last season.
And the more likely it is that if he wins that same award this season, it'll be with a whole different meaning.
Dave D'Onofrio covers the Red Sox for the New Hampshire Union Leader and Sunday News. His e-mail address is


text:
The dcom rpc Vulnerability bring great damgae to a host,when we use the exploit to test the Vulnerability,the service of the host will be crashed or we will get a shell.
But ,these result is not what I want.
I want to make a tool to scan,to test whether a remote host has the Vulnerability or not,whithout crashing the services or getting a shell.
Can I?and how to do?
Sorry for my poor english.


text:
Nordstrom Rack Tustin Market Place
Contact2882 El Camino Real, Tustin, CA 92782
Store #168
Store HoursMon-Fri: 10am-9pm
Sat: 10am-8pmSun: 11am-7pm
Special Store Hours
Sep 24: 10am-6pm
Sep 24: 10am-6pm
Have you visited Nordstrom Rack Tustin Market Place lately?Tell us what you think
New Opportunities
Careers at Nordstrom
We're always looking for people who have a passion for fashion, who love helping people and who have that special knack for combining the two. If you're motivated, enthusiastic and ready to take your career to a whole new level, explore Nordstrom Careers today! Learn more
New Store Openings
Is a brand-new Nordstrom or Nordstrom Rack coming to a shopping mall near you? Check our list of all stores slated to open from now until 2021. View Openings


text:
Just read this on CNN.
There is more to the article if you click the link above.Found at: http://www.cnn.com/2006/TECH/interne...ing/index.html
ATLANTA, Georgia (CNN) -- It's just the news that hardworking taxpayers want to see in their inbox: an update on their refund from the Internal Revenue Service.
But instead of clicking on that e-mail's links, federal officials advise you to hit the delete key.
That's because dozens of scams, known as "phishing" schemes, are making the rounds, poised to steal your personal information.
"This phishing scheme is exploding," said IRS Commissioner Mark Everson.
"Last year we got wind of seven different kinds of schemes. That was in all of 2005. This year we've already seen 65."
Even the commissioner of the New York State Department of Taxation and Finance got one of the phishing e-mails -- on his government computer.
"It's a reflection of how brazen these crooks have become," Commissioner Andrew Eristoff said.
"Here they are targeting a tax administrator with a tax refund scam. Unbelievable," he said.
Phishing is an e-mail trick that "lures" users with a promise of money or an urgent security warning that asks users to update their information. But instead of going to a financial institution or the government, the precious personal data goes to identity thieves.
I think I'm moving off email. Maybe communication all together.


text:
Signs of Life :: Act Two for Clean Water
Act Two for Clean Water
The U.S. Senate may be poised to undo a Bush-era policy that undercut protection of the nation's waterways.
Until 2002, the U.S. EPA and the Army Corps of Engineers had the authority to keep pollution out of creeks and stop builders from paving over small wetlands.
But two rulings on the Clean Water Act by the U.S. Supreme Court took a narrow reading of the law's language, limiting the Act's jurisdiction to "navigable waterways" and the small streams and rivers that are connected to them.
The rulings stripped protection from 20 million acres of wetlands and 60 percent of the nation's stream miles, such as the Los Angeles River and nearly all of Arizona's small streams.
Now 24 senators have sponsored a bill that would restore those protections. The Clean Water Restoration Act has passed the Senate Environment and Public Works Committee, and is headed for the Senate floor. The act has the support of a large number of environmental, wildlife, and fishing and hunting groups, along with the Water Environment Federation, which represents the water treatment industry, though the law is meeting resistance from big agriculture and developers.
—Madeline Ostrander
Bundanoon, Australia, May be First to Legally Ban Bottled Water
In a July 4 vote, Bundanoon, Australia, may have become the first community in the world to legally ban bottled water. The ban was promoted through the grassroots "Bundy On Tap" campaign. The town plans to implement the law by September, once it sets up bottled water alternatives, such as several new free filtered "water stations" to be placed around the community.