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Beyond Fortified Foods: New Clinical Trial Affirms Softgel Sterol/Stanol Supplement Effective for Lowering Cholesterol Levels
Jan 08, 2013, 08:00 EST
As Part of the National Cholesterol Education Program (NCEP) Therapeutic Lifestyle Changes (TLC) diet, Sterol/Stanol Softgels Offer a Convenient Way to Improve Cholesterol Levels
NORTHRIDGE, Calif., Jan. 8, 2013 /PRNewswire-USNewswire/ -- The following is being released by Pharmavite LLC:
A research study published this month in the journal Nutrition demonstrates the effectiveness of a sterol/stanol ester-based softgel capsule for decreasing LDL cholesterol in individuals with high cholesterol levels. Few clinical trials have investigated the effect of plant sterols and stanols on cholesterol levels when administered in supplement form; most studies have examined the effect of plant sterols and stanols from fortified commercially available food sources such as margarine-type spreads, yogurt, and orange juice. Nature Made® provided the sterol/stanol esters in the form of its CholestOff® softgel dietary supplement.
Plant sterols and stanols occur naturally in plant-based foods and their physical structure resembles cholesterol in the body. Sterols and stanols have been shown to reduce cholesterol levels by reducing absorption in the intestinal tract. Throughout this study, all subjects followed a heart healthy diet (National Cholesterol Education Program TLC Diet). Subjects were divided into two groups. One group received a sterol/stanol softgel for 6 weeks while the other took a placebo. After the six weeks, the groups switched treatments while maintaining the same TLC diet. After taking the sterol/stanol softgels daily for six weeks, cholesterol changes, in the per protocol group,were statistically significant (P < 0.05) for LDL cholesterol (also known as bad cholesterol) (-9.2%), non-HDL cholesterol (-9.0%), total cholesterol (-7.4%), total cholesterol/HDL-C ratio (-5.4%), and triglycerides (-9.1%).
"This study is a significant contribution to our overall understanding of dietary supplements' role in the reduction of blood cholesterol levels," said Dr. Kevin Maki, lead author from Biofortis Clinical Research. "Our results show that a softgel capsule can be an effective and convenient way to deliver a therapeutic dose of sterol/stanol esters in a non-food matrix."
The softgel supplement used in this study provided 1.8 grams of esterified plant sterols and stanols (in two softgels taken twice daily) with meals. This dosage is within the range for which effective reduction of LDL cholesterol levels in individuals with high cholesterol have been observed in previous scientific studies. A typical Western diet includes roughly 150 to 400 milligrams of plant sterols and stanols, a level unlikely to change blood cholesterol levels.
"Nature Made developed the CholestOff dietary supplement to ensure that the dose provided was consistent with the scientific literature that showed an effective reduction in blood cholesterol levels," said Dr. James Brooks, Vice President, Science and Technology, Pharmavite, LLC and study co-author. "Previously, a study was published showing that the tablet form of CholestOff lowered cholesterol levels significantly so this new study of our softgels adds to the assurance consumers can have using this product."
The randomized, placebo-controlled, crossover trial lasted 17 weeks and involved 28 predominantly non-Hispanic, non-smoking overweight men and women. Study participants followed the National Cholesterol Education Program (NCEP) Therapeutic Lifestyle Changes (TLC) diet throughout the duration of the study, starting five weeks before the plant sterol/stanol capsules and placebo capsules were administered. The TLC diet is a low saturated fat, low cholesterol diet developed by the National Institutes of Health to lower cholesterol levels in an aim to reduce heart disease risk. Five weeks after starting the TLC diet, subjects were randomly assigned, in a double-blinded manner, to receive either Cholestoff softgels or a placebo softgel for six weeks each. After six weeks, study subjects crossed over to the opposite product for another six weeks. Participants were restricted from consuming dietary supplements and plant sterol and stanol fortified foods during the study and four weeks leading up to the study.
The study findings provide additional science on the effectiveness of a supplement delivery/form of plant sterols and stanols from CholestOff softgel capsules for lowering blood cholesterol levels as part of the NCEP TLC diet in subjects with high cholesterol. For some individuals, the capsules may be a more convenient and appealing option for individuals managing their cholesterol that could increase compliance during long-term use. Long term compliance is especially important when considering the potential usefulness of a product for lowering cholesterol. For more information about Nature Made® CholestOff, please visit NatureMade.com.
About Pharmavite LLC:
For more than 40 years, Pharmavite LLC has earned and maintained the trust of healthcare professionals, consumers, and retailers by manufacturing high-quality vitamins, minerals and other dietary supplements, and all-natural foods under its Nature Made®, Voots®Veggie Fruit Tarts and SOYJOY® brand names. Based in Northridge, California, Pharmavite LLC operates as a subsidiary of Otsuka Pharmaceutical Co., Ltd. For more information, please visit Pharmavite.com.
SOURCE Pharmavite LLC


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Langevin Makes the Case for Establishment of White House Cyber Security Director
WASHINGTON, July 20, 2011 – Despite bipartisan agreement over the need for effective cyber security legislation, members remain divided over authority and enforcement specifics. In an opinion piece in the Saturday edition of the Washington Post, Rep. Jim Langevin (D-RI) critiqued another article published early July in which Sens. Joe Liebermann (ID-CT), Susan Collins (R-ME) and Tom Carper (D-DE) recommended proposed legislation that would grant the Department of Homeland Security (DHS) statutory authority to work with industry to identify and evaluate critical cyber infrastructure and establish best practices between government and the private sector in order to improve security. Keep Reading

subset: commoncrawl


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*** (out of four)
Jane (Dree Hemingway) is a young L.A.-via-Florida girl who's as obnoxiously aloof as she is stick-thin. Sadie (Besedka Johnson) is an elderly widow who acts as if it's a huge hassle to give Jane tap water—sans ice—after Jane drives Sadie home from the store. There's no reason to think these two could be friends.
Yet director/co-writer Sean Baker makes the Independent Spirit Award-winning "Starlet" work better than it should, despite building on contrivances and too-blatantly rigging emotional turning points.
Jane drives Sadie home because Jane recently purchased a Thermos at Sadie's garage sale—only to find about $10,000 inside. Jane spends a bit and stashes the rest. Sadie doesn't seem to need it, and Jane doesn't confess her findings. For now, Jane just hangs with Sadie, who gradually believes the young girl isn't trying to scam her out of something—well, after Sadie sprays her with mace.
By the way, Jane and her roommate Melissa (Stella Maeve) are porn stars, but Baker does an even better job than the recent "About Cherry" in presenting the job as a job and not making a big deal out of it. (Google the recent study that found female porn stars actually have high self-esteem and positivity.) That said, Melissa is bad news—as Zara Valentine, she stars in "Hot Mess," a title Melissa deserves—and suffice to say there's only so long two roommates can live in peace when one has hidden a bunch of cash and the other is bananas.
An effectively sleazy turn from James Ransone (very funny in "Sinister") as Melissa's boyfriend Mikey, who demands Jane light his bowl so he can continue playing a video game, underlines the fragility of Jane's situation. Baker lets us fill in most of the gaps of how she got to this place. Hemingway's very good at taking a character who often seems like an insufferable L.A. stereotype and shading her with a range of values and feelings that exist somewhere in those thigh-high socks. She and Johnson help Jane and Sadie's relationship to develop hesitantly but tenderly, to the point where any secrets between them almost don't matter based on the role they play in each other's lives.
By the time Sadie "star-sits" for Jane's (male) dog, Starlet, Sadie cares enough to cry as she walks around town looking for the lost dog. "Starlet" succeeds because it makes us believe that she's not just tearing up over the four legs that got away.
Watch Matt on "You & Me This Morning," Friday at 6:55 a.m. on WCIU, the U
Want more? Discuss this article and others on RedEye's Facebook page.


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These are all the photos from the galleries for Dead or Alive 2. They are pulled from both convention galleries and albums not marked as photoshoots from our photographers. Click on a photo to view more details about it.
ACP, ACE, ACS are part of the ACParadise.com Network, Copyright © 2000-2018
""Con events! I've only ever done one and it kind of ATE MY SOUL (lololololol) but was totally worth it. Moar moar I say! <3""


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The netbook newbie's guide to Linux
'We're the Fukarwi'
I'm not just going to tell you to type mysterious command lines and take them on trust. I do think we need to know a little bit about what we're doing, although I'll try not to get bogged down in a lot of unnecessary detail. The command line you'll be typing now is as follows:
sudo yum list | less
Sudo is a command that says: OK, I don't have supervisor status on this machine - I'm not 'root' - but please treat the command that follows as if I did. Provided I'm on a list of approved
sudo users,
yum evokes the package manager, and the
list parameter tells
yum to give me a list of stuff.
I'll look at why you need
sudo, and what root is all about, in a future column.
The character,
| is a called a 'pipe'. It's an instruction to feed the outcome of the previous command into the command following the pipe.
Less works like
more in DOS - more or less - as a full-screen text display that allows you to step through the output, page by page. You can exit from
less by hitting the Q key. Try it.
Yum in the Terminal
Not all forms of Linux use
yum. The Eee PC, for one, uses
apt-get - short for Advanced Packaging Tool - which does the same job.
If you're already connected to the internet, you'll notice that the list you get isn't just an inventory of what's on your machine. It consists of three columns. The left-hand column lists the name of the program or component, the middle column gives you its version number and the third line confirms whether that component is installed or available elsewhere online. In this case, elsewhere is Fedora, an online repository of the version of Red Hat Linux on which Linpus is based. In theory, this means you can use
yum to install a new Fedora packages on your AA1, but I don't recommend trying that at this early stage.
There is one really useful thing we can do, however. If, like me, you have other machines attached to your network offering Windows fileshares, the AA1 will appear to know nothing about them. It can only browse files on the local machine. So what we're going to do now is 'mount' a Windows share as if it were part of the AA1's own local file system. Linux in general does a superb job of accessing Windows shares through a technology called Samba. Samba provides a Windows-compatible file system called cifs, and a utility to mount this file system called
mount.cifs. But don't worry about it. The ordinary
mount command knows to use
mount.cifs if you evoke it with the
-t cifs parameter. And
mount.cifs is smart enough to insert the relevant filesystem module (cifs.ko) into the OS' kernel automatically.
The user base for netbooks is growing fast. The following forums deal with the netbooks we've been discussing here:
The Asus Eee PC series: forum.eeeuser.com
The Acer Aspire One: www.aspireoneuser.com/forum/
The MSI Wind: forums.msiwind.net


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WASHINGTON (AP) — A federal appeals court ruled Friday that White House visitor logs for the president and most of his staff are not public information subject to disclosure requirements of the Freedom of Information Act.
The 3-0 decision would keep the visitor records confidential for up to 12 years after President Barack Obama leaves office.
The appeals court ruling dealt a defeat to a private group that asked the Secret Service for all White House visitor logs from Obama's first seven months in office.
"Congress made clear that it did not want documents like the appointment calendars of the president and his close advisers to be subject to disclosure" under the Freedom of Information Act, wrote Merrick Garland, chief judge of the U.S. Court of Appeals for the District of Columbia Circuit.
Judicial Watch, a conservative-oriented watchdog group that sued in an effort to get the records, said it is considering an appeal.
"Decisions like this turn the Freedom of Information Act from a transparency law to a secrecy law," said the group's president, Tom Fitton.
Disclosure battles over White House visitor logs have been a staple of both Democratic and Republican administrations.
In May 2006, the White House and the Secret Service asserted that the visitor records were presidential records, as opposed to agency records belonging to the Secret Service. Under federal law, presidential records can remain confidential for up to 12 years. As an executive branch agency, the Secret Service is subject to the Freedom of Information Act, which requires public release of material unless one of nine exemptions applies.
In Friday's ruling, the chief judge said that construing the term "agency records" to extend to White House visitor logs could substantially affect the president's ability to meet confidentially with foreign leaders, agency officials, or members of the public, which could make FOIA a potentially serious congressional intrusion into the conduct of the president's daily operations.
Garland is an appointee of President Bill Clinton. The other two appeals judges on the case were David Sentelle and Stephen Williams, both appointees of President Ronald Reagan.


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Sheriff: Threat with cordless drill leads deputies to 17 lbs of pot
WALDPORT, Ore. - A man accused of threatening his live-in girlfriend with a cordless drill faces drug charges after police found 17 pounds of marijuana in his home during a routine followup, the Lincoln County Sheriff's Office said.
The investigation started just after 1 a.m. Thursday, January 23, with a report of a domestic disturbance in Waldport.
The investigation led deputies to believe Ian Deenihan, 27, had pushed his live-in girlfriend down and threatened her with a cordless drill, the sheriff's office said.
Deputies located Deenihan around noon near Port Dock Seven in Newport and arrested him on one count of menacing.
Later that afternoon, deputies returned to Deenihan's home for a routine followup.
There they found more than 17 pounds of marijuana along with a scale and packaging and cultivation supplies in an upstairs storage closet, the sheriff's office said.
Deputies charged Deenihan, who was still in custody at the Lincoln County Jail, with unlawful manufacture of marijuana; unlawful delivery of marijuana; and unlawful possession of marijuana.
His total bail was set at $350,000.
Deenihan remained jailed as of Monday morning, according to jail records.


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January 23. 2013 10:58PM
NH women react to end of ban on combat
From Staff and Wire Reports
Combat veteran Nancy Young of Auburn was thrilled to hear other women will get the chance to serve on the front lines in the military.
A retired master sergeant with the Air National Guard, Young served as a gunner on a truck in Iraq. She said some women may want to think thoroughly about seeking posts previously limited to men, but she is glad there is finally going to be a choice.
"I think it's great that they're going to be given the opportunity to try," Young said Wednesday. "It's been a long time coming."
Defense Secretary Leon Panetta said Wednesday he has decided to lift the military's ban on women serving in combat, a move that could open thousands of front-line, war-fighting jobs to female service members.
New Hampshire Sen. Kelly Ayotte said she is pleased at the news.
"I've seen firsthand servicemen and women working together in a range of dangerous operations to achieve our military objectives - and today's announcement reflects the increasing role that female service members play in securing our country," the Republican said in a written statement. "As the Pentagon begins the review process, I'm also glad that military service leaders will provide guidance on how best to implement this policy change."
Carolyn Hodge of Goffstown enlisted in the Marines in 1978. Women going through boot camp were not able to qualify with weapons - as their male counterparts were required to do. Now a readiness NCO at the National Guard's Joint Force Headquarters in Concord, Hodge was excited to hear that women will be getting the same opportunities as men.
"I think it's going to create wonderful opportunities for some great female leadership," she said. "We've seen it come slowly a long way. I would have liked to have seen it move a little quicker."
Sen. Carl Levin, the head of the Senate Armed Services Committee, said the lifting of the ban reflects the "reality of 21st century military operations."
The American Civil Liberties Union had filed a suit in November seeking to force the Pentagon to end the ban.
The decision, expected to be formally announced later, would give the individual military services until 2016 to seek an exemption if they believe any jobs should remain closed to women, a senior defense official said. It was unclear when the change would go into effect.
"This policy change will initiate a process whereby the services will develop a plan to implement this decision, which was made by the secretary of defense upon recommendation of the Joint Chiefs of Staff," the official said.
The decision overturns a 1994 policy that prevents women from serving in small, front-line combat units.
It comes nearly a year after the Pentagon unveiled a policy that opened 14,000 new jobs to women, but continued to prohibit them from serving in infantry, armor and special operations units whose main function was to engage in front-line combat.
"If they want to become infantry, or tank duty, that's a full-time day-in, day-out training. That's all you do," Young said.
Asked last year why women who had served in Iraq and Afghanistan conducting security details and house-to-house searches were still being formally barred from combat positions, Pentagon officials said the services wanted to see how they performed in the new positions before opening up further.
About 2 percent of U.S. deaths in Iraq and Afghanistan have been women. Some 280,000 women have been deployed to the war zones over the past decade, about 12 percent of the U.S. total.
Defense officials noted that 10 years of combat had made it clear that some of the military's gender-based restrictions were obsolete because the battlefields faced by U.S. troops in Iraq and Afghanistan had no clear front lines and no obvious ways to limit exposure to the fighting.
"This policy has become irrelevant given the modern battle space with its nonlinear boundaries," the Defense Department said in a report to Congress.
More than 200,000 women serve as active-duty members of the military, including more than 37,000 officers.
New Hampshire Union Leader Staff Writer Doug Alden contributed to this report.


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This site might contain information that is painful for dogmatic people
The greatest secret/prophecy/miracle in history
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Nevertheless, without much using our reasoning faculty, we have an innate system that protects our body from harmful substances. Then, it is a mystery how we put information and assertions, especially the most bizarre ones, into our brains without subjecting them to rigorous test of critical thinking.
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Honda Ridgeline Real World MPG Numbers
Recent trip Minneapolis to Grand Forks 75-80 MPH going against the wind 95/5 HWY/City 17.5 MPG Return trip 75-80 MPH 100% HWY 19.38 Total for trip 18.24 MPG with speeds of 75-80. Total milegae on truck 3000 miles one month old.0
I have a 2006 Ridgeline and after almost 40,000 miles my mileage has improved rather dramatically versus new. In my normal (aggressive) driving on the highway, the vehicle delivers 21.5 MPG at approximately 700 feet above sea level in 50 degree F weather. Recently I tested it over a 400 mile stretch (Minneapolis to Chicago) at roughly this elevation, 60 degree F weather, at the posted 65 MPH limit using cruise control and the truck delivered 25.2 MPG. That's TWENTY FIVE POINT TWO miles per gallon.
For new Ridgeline owners, hang in there. A little mileage on the odometer, a steady foot, some attention to the posted speed limit, regular maintenance, and properly inflated tires should yield mileage that well exceeds that posted by the EPA.
By the way, I do not have a roof rack, and I do have a cargo bed tonneau cover....both of which likely contribute to the above-average mileage.0
A vehicle that size with the aerodynamics of a brick getting 25.2MPG. Wow. Did you have a 50MPH tail wind?0
I have another chance to test that one today with a similar trip, albeit shorter, from Chicago to St. Louis. I rarely drive the speed limit yet if this kind of mileage results, I'll be doing a lot more of it. Generally I am into a headwind when heading southbound on I-55 in Illinois, and it will be interesting to see the resulting mileage.
Regarding aerodynamics, not having a roof rack and covering the cargo area probably have something to do with this truck delivering somewhat better mileage than a brick. I just refilled my tank from a combination of city (90%), and Highway (10%), and the Ridgeline delivered that characteristic 15.4 MPG. Getting that mass to move from a standstill certainly requires that V6 to drink deeply...and the lower gears required certainly boost the RPMs.
I'll post after this next round-trip...which should total about 560 miles on flat terrain. My biggest challenge will be staying in the right lane for most of the trip.
I understand your skepticism. All I can do is report the facts...and will keep doing so.
I was also hauling about 500 LBs of college goods home plus 2 other passengers. I was happy getting 19.2 MPG on the way home at 75-80 MPH. I have taken other trips to Grand Forks with my wife Sonata and we will get 27-28 going to and 31-32 going home. I also drive to Chicago and find the same going to Chicago I get 2-3 MPG better than driving back to Minnepolis. In the Twin Cities I stay in the right lane and drive 55-60 on the HWY. In the suburban towns I time the lights and do slow acceleration, I hope to average 20 MPG on this next tank full 50/50 HWY/Cty. One thing I do not do is slow or impede the flow of traffic.0
what did you get on your trip to St louis?0
2 months old 4500 miles average since purchase 18.4 MPG consisting of 50/45/5 HWY/Suburban/City. Last tank 19.1 50/50 HWY/SUB. Changing the oil in the next week going to synthenic see what that brings.0
What kind of tonneau cover do you have? Is that very heavy? Thanks!0
What kind of tonneau cover do you have? Is that very heavy? Thanks!
I'm still looking for the right mix of tires, tire pressure, premium gas?, etc. to get me over 20 mpg. I just got a 2006 with 19k miles and so far my MPG is 19.75, 18, 17, and 18.75. And I'm driving it very easily!0
I borrowed my brother's Ridgeline to collect this info. Tested both pulling a trailer and without the trailer:
Details of the test can be found here.0
Just how far did you run this test? I read your link, but did not see this.
Your graph indicates at 74mph you achieved 24.7mpg.
I'm sorry, but I just don't believe this is 'real world'.
Mine gets about 19/19.5 at speeds around this. The very best I think I've gotten on mine was about 21.5.
My original tires indicate a max pressure of 35psi. The door tag has Honda's recommendation of 32psi. This small of an increase in tire pressure and a bed cover, in my opinion, would not increase milage by some 15% over my max milage. My milage was from fillup to fillup, which is usually 15 gallons or more.
If what you are reporting is a steady state mileage over a level 1 mile or so - I don't see what this has to do with any real world driving.0
eddiem Posts: 6The testing data documented may be true on that stretch of road, but I can tell you that "real world" driving will yield very different and varied results. I was considering the Ridgeline, but bought a Dakota. It has a digital mpg readout, and I can tell you that reaching 20, 21 or 22 mpg is relatively easy, but only on a flat stretch, without acceleration. Try this. Reset your mpg meter to zero, and take your vehicle out for a drive. If the engine is cold, and you take off from a dead start, climbing a slight hill, you may see 9, 10, 11 & 12's in the readout. It is very easy to decrease your actual mpg with something as simple as slowing down and accelerating in traffic. As mileage (on the tank, which is when I reset the display after refueling) accumulates, that has a smaller affect on the "tank mileage", but it still affects it. Reseting the display on the highway will show you your "instantaneous" mpg, not your average over that tank or over several tankfuls.
I have 20,000 miles on my 07 4x4 3.7l / 6 spd manual Dakota Quad Cab, and I drive like an old lady, trying to maximize my mpg's. It's a game, but it is much easier to drop your mileage than it is to increase it on any given tank. FYI, my readout is about 95% accurate when compared to the fill and record mileage data method, so I know it's accurate. These numbers may only be "snapshot", not what you are going to get unless you take it out and empty a tank on a long (highway) run at conservative (less than 70 mph) speeds.0
The figures in the graph are meant primarily to show the impact of speed VS fuel consumption.0
My '06 Ridgeline with 60,000 miles gets about 21 MPG (US) HWY at this speed. The graph is about right for my experiences if I'm careful in acceleration. Keep in mind I have no roof rack and a tonneau cover on the bed. Tires are filled to max recommended pressure (checked and rotated regularly).
Driven hard the Ridgeline sucks significantly more fuel. Its all in my driving habits. As some indication of my conservative driving, I still have plenty of tread left on my OEM tires and "just" had the rear brake pads replaced.0
stevedebi LAPosts: 4,098"Your graph indicates at 74mph you achieved 24.7mpg.
I'm sorry, but I just don't believe this is 'real world'. "
That was imperial MPG, not US MPG. The imperial gallon is larger.0
That is about 20.6 mpg to the US gallon.0
You are right. I apologize. I read the wrong entry in the data.
And, 20.6 mpg to US gallon I would agree is an attainable figure for a steady, level 74mph (I think this was the speed in the graph.)0
Comparing our 09 Ridgeline mileage to our 03 Pilot mileage is a little disappointing.
I don't recall what the Pilot's window sticker EPA Mileage was, but it got way better than advertised by the time the odometer hit the 1,000 mile mark.
Local driving, the Pilot returned 17-19 mpg. Highway mileage at 60 MPH would be 26-28 mpg depending on use of the AC. Increasing the speed to 70 would drop the mileage to the 22-24 mpg area. Again depending on use of the AC.
Ridgeline mileage in local driving is more in the 15-16 mpg range and highway mileage is a very disappointing 22+/- at 60 mph. with the AC OFF. I expect it would drop to 20 or less at 70 mph.
Realizing the window sticker is 15-20 and are grateful we are doing a bit better than that, I'm still in wonderment as to why it is so much worse than the Pilot.
Weight of the 2 vehicles is virtually the same, same engine displacement, similar frontal area, both AWD, same driver, same driving techniques, same fuel at the same pumps.
Must have something to do with the open bed at highway speeds, and transmission shifting preferences in local driving.
Other than that we really like the Ridgeline.
cyclone6 Posts: 8Don't forget that even though the Pilot has the same engine, it has the VCM (variable cylinder management) feature that causes the engine to only run with 3 cylinders when cruising or otherwise not under stress. I don't think the Ridgeline has this. My 2007 Pilot has gotten over 28 mpg's on a couple of different trips which is far more than it is rated.0
As I've probably stated in this segment before, I feel since ethanol has been introduced in the gasoline in my area a couple of years ago, I feel all 3 of my vehicles has lost about 2mpg. This includes my Ridgeline.
Ethanol is a huge failure because of its milage reductions and diversion of livestock food grain to a different purpose.0
ridgeline1959 Posts: 5I have a 2008 best I've done on the HWY 23.5 @ 73 MPH on a 400 mile trip. That was getting gas @ the highway and pulling off and getting gas again. City driving around the twin cities which is about 50/50 hwy/suburban driving the top I get is 19.5 in the summer about 17.5 winter. I'm a conservative driver and I do shut my car off @ intersections when the light will stay red longer than a minute.(about 2 times a day) Pulling a boat about 13 MPG. Now when my wife drives the Ridge she gets about 14 MPG, ie jack rabbit starts and race to the red line!!0
209flyboy Posts: 1Mileage on my new 2009 Ridgeline has been getting better with time. I have found a new trick for increasing mileage and that is to use the cruise control as much as possible, even in the city where there is ample road to do so. Just don't do jackrabbit starts. This will kill your mileage. You've got to remember your driving a truck with big tires which increase rolling resistance.
I have found that by setting the cruise control slightly higher than my desired speed and then, using the decelerate control bring the speed down to the desired speed. By doing this, you will see the mpg stay higher than if you just set the control at the speed you want and don't go over the\at speed first.
I have been getting 18.5 to 19.8 in the city using this technique. My highway mileage has shown 22.7 to 23.8 consistenly at 68mph on reasonably level interstates. Keeping the vehicle at 70mpg is max for me. I notice that speeds above 70 mpg start to take a toll on mileage because of wind resistance. There is a big trade off speed vs wind impact. Another thing to remember is not to use the cruise control when the road takes a steeper climb. This causes the tranny to downshift and the engine runs faster increasing fuel consumption.0
With about 8K on the clock the mpg is getting better. Local commuting is more in the 18+/- arena. When new, it was in the 15-16 mpg range.
Recently my wife and I took a 1 day road trip from south of Atlanta to Cherokee N. Carolina. Typical N. Georgia rolling hills most of the way with mountains the last 30 miles or so. One area was steep enough that the tranny dropped to 3rd gear. About half the trip was X-Way, 1/4 four lane roads with traffic lights, and 1/4 two lane roads with some small towns. Total trip was about 385 miles. Travel speed was posted speed limits and very little speeds over 65. Stopped to eat twice and once for a "Pit Stop". Spent about 2 hours at the destination.
Gauge in the car said we got 24.8 mpg. Gas pump and calculator showed 25.1 mpg. Filled up at the same pump before and after the trip. Let the nozzle run on the slowest setting and removed it on the first click both times. This is the first time the gauge has shown less than the calculated mileage. Might have something to do with the constant running vs my usual traffic type driving.
A week or so later I (alone) took a trip of about 175 total miles to north Georgia and back, but not into the mountains. There were constant rolling hills, for the entire trip. Ran the posted speed limits but not over 65 much at all. Measured the mileage going with a top speed of 62. Trip home had a top speed of 65. RL gauge showed 27.8 one way and 27.7 the other. Did not calculate at a fuel pump. Even if the gauge is optimistic by .5-.8 mpg, which is usually the case, that is still good mileage for a "brick".
Conditions were a pleasant day and AC was not required. Cruise was used when ever possible. FWIW I firmly believe that most RL will achieve this kind of mileage under similar conditions. In my heart of hearts I believe that if I had driven 70 mph the economy would have dropped 5-7 mpg. But I would have gotten there a few minutes quicker.
Problem with most drivers is a desire to buy cheap gas and run as fast or faster than everyone else. I buy Chevron or Shell 87 octane which have proven over and over to get better mileage than the economy fuels for us.
Check out the links at the top of this web site. -> http://www.toptiergas.com/
scottmpg Posts: 1I bought my 2008 Ridgeline used 4 months ago with 25K miles. I now have 32K and have been getting 15.5, 12.5, 13.5, and twice I got 16.5 mpg. I drive 50% highway & 50% city/suburban. I live in Houston, Texas. I don't haul anything. I'm fairly easy on the pedal and I don't see how fast I can get to the next light. The dealer said I'm getting normal mpg. Can any body tell me if this is true?0
To scottmpg, I had my 2006 Ridgeline for 6 months and put 10,000 miles on it. I didn't take any long trips but did a lot of short trip driving and I always stayed at 18 mpg or better. I drove it as you say you're driving. I read on one post that if we have a truck we're just pushing a brick down the road and shouldn't expect good MPG. I have had a 2005 Tundra 2wd double cab for 2 months and am bouncing between 17-18 mpg....just added a Extang bed cover and hope to see 1/2 of the 10% MPG improvement they advertised...but I'm not holding my breath. I will add new spark plugs (probably the NGK fine wire Iridium IX) next...oh and I still have to change from crude oil to my Amsoil 0w30. Maybe I will get another 1-2 mpg from these latest tweaks. Just this morning a buddy sent me this: "A good hot FORD plug is the best you can do on ANY internal combustion engine running 87 to 104 octane. All you do with a plug will be robbed by ONE under inflated tire.....im serious!!! Keep the air flowing into the engine.....run a good plug...keep the tires up....keep GOOD gas in it and its about all you can do. Slow starts and not going over 50 make an INCREDIBLE diff as well as high octane gas."
Sounds like your Ridgeline may need some tweaking also....maybe at the dealership after you do all you can do? Good luck!
You are getting about what I get.
I think I just filled up and it was 17, with a highway trip on that.
I feel all my vehicles lost around 2mpg where 10% ethenol was required. I've seen 21mpg on one highway trip in my 2006 Ridgeline, and this was on gas without ethenol. I doubt I will ever see this milage again.
I do drive fast, 70 or 75 depending on posted speed limit. I do try to keep air at 32pounds or more, but this truck does seem to leak or drop a lot of presssure in cold weather. I've had the low pressure warning come on twice since owning it. It comes on at 26#.0
rcummelin Posts: 184Your mileage seems low to me, but what do I know?
We had an '08 RTS that got about 16-17 in town and 19-21 on long freeway trips at 75-80 mph.
We traded our '08 for a new (leftover) 2010 RTL in December. It's not broken-in yet, but current mileage is 15-16 in town and 18-20 on the highway. I'm hoping it will improve after it gets a few thousand miles on it.
I agree that ethanol added to gas kills your mileage numbers. In my experience, 10% ethanol = 10% worse mileage. Almost like paying for something that doesn't even combust in the engine--weird. We are forced to buy gas with ethanol in the winter, but can get REAL gas in the summer here in Colorado, and the mileage numbers go up when the ethanol goes away.
On other Ridgeline forums, some owners claim to run 34-35 lbs. of air pressure in their tires to improve the mileage and it seems to work if they do lots of highway driving.0
dboe Posts: 69Actually, 34-35 lbs is only a couple above what Honda recommends. It should not be an issue at all. Mfrs have to compromise between mpg, tire life, and ride comfort.
I've noticed the slightest increase in ride firmness, about the only penalty driving a couple of psi over. Need more time to evaluate mileage.
With Ford's new ecoboost engine, and the mileage/hp ratings of some others, I have to wonder the direction Honda is going. Makes me think maybe another year for the RL and then no more.
I think there has been a slip in quality too, although over the long haul I think a Honda will always persevere. But I am concerned they are not as innovative anymore. It's great having tried and true models like Accords and Civics, but things have become pretty stale in light of the competition, including other imports. Oh well, just my rant!
Back to the mileage, on longer trips I try to hold to 65mph even in a 70 zone. It seems as soon as the tach starts to rise the slightest bit above 2K, mpg starts heading for the toilet. Don't get me wrong, overall still love the truck.0
Our 09 Ridgeline consistantly returns 25-27 mpg on the road at 60 mph. Depending on terrain and load. At 70 mph the mileage drops to 20 +/- mpg. Running the AC lowers those numbers by about 1 mpg.
I agree with dboe. When the tach hits 2000 the milesge drops fast.
stever Posts: 52,683A reporter is interested in talking with consumers about how fuel economy requirements are changing what people drive. He is looking for consumers who consider fuel economy their top consideration while shopping for vehicles that range from pickups to luxury cars to EVs. If you are interested in commenting on your experience, please reply with your name, phone number and email address to [email protected] no later than 5pm Pacific this Wednesday, September 21st.0


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Last Updated on Friday, 05 February 2010 14:46 Written by Elizabeth Barrett Friday, 05 February 2010 14:44
Senior prom first date for couple who plan to marry in June
Kristen Yilk and Joey Rubenthaler were members of the last class to stroll the halls of the old Gothenburg High School.
Shortly after they graduated with the Class of 2003, the building was demolished because a new one had been built.
Kristen and Joey shared many classes. They both played sports for the Swedes.
Joey, who attended country school until seventh grade, was also involved in FFA, band and student council while Kristen—who lived in town—played in the band and was also a member of student council.
At the time, they were just classmates.
Nothing more.
More than midway through their senior year, they were winter coronation candidates and walked together across the gym floor during the ceremony.
If there was a spark then, neither Kristen or Joey said they felt it.
Less then a month before they graduated, things changed.
"We had never really talked until then," Kristen said.
The two seniors were at a friend's house.
"We were just sitting outside and talking and we had our first kiss," Joey said.
At the time, Kristen was working at the Wellness Center as a receptionist and Joey would visit and keep her company.
"Shortly before prom on April 25, we made it official," she said. "It was probably our first real date. We were both excited."
Joey remembers being a bit nervous when he drove to Kristen's house.
"I think I was even shaking a little when I put on her corsage," he said.
After high school graduation, they both headed to the University of Nebraska-Lincoln where Kristen received a degree in dental hygiene and Joey an athletic training degree.
A little more than seven years later, the two classmates will start sharing a life together as husband and wife.
On June 12, Kristen will stroll down the aisle of Our Lady of Good Counsel Catholic Church to marry Joey.
Seven years may seem like a long time to date but while in college, both said they thought their paths would probably continue in the same direction.
"We weren't always positive it would end up this way," Joey said. "Like any young couple, we had some rough patches but we're happy everything turned out the way it did."
Kristen said they had talked about marriage but agreed that it needed to be after they graduated from college.
Joey said it's fortunate they have grown together and had time to learn about each other.
"I think that we are completely different people from when we started dating at age 18," Kristen said.
The marriage proposal came about on a cold day in January of 2009.
Kristen said she arrived in Lincoln for a weekend while Joey was at class.
He later called and said his car wouldn't start and asked if she could pick him up.
When she arrived, he called and said his car had started and he was driving home.
"When I got to Joey's house, all the lights were off and I thought that was pretty strange," Kristen said. "When I got to the front door, there was a single rose and inside he had several tea light candles lit all the way to his room."
Joey had more roses in his room which was where he knelt on one knee and proposed.
To make marriage work, Kristen said both people must be committed to making the relationship work.
Joey said it also helps to enjoy some of the same things.
"You must also know what it takes to make the other person happy," he explained. "Marriage is about just wanting to do whatever it is that will make the person's day better."
In addition, Kristen said a good marriage means maintaining a good balance of work, friends and family.
"You both also need a strong relationship with God," she said. "And you need to be able to laugh with each other and have a sense of humor."
These days, Kristen, 25, works as a dental hygienist in Shenandoah, IA, and Joey, 24, lives in Lincoln where he'll graduate with a masters degree in education administration in May.
He works for Nebraska Orthopaedic and Sports Medicine and is also the head athletic trainer at Norris High School.
Because they have had more than a year to work on wedding arrangements, Kristen said plans have been going well and have not felt rushed.
"I'm the only girl in my family so my mom is having a blast," Kristen said. "I don't think she's missed an episode of 'Say Yes to the Dress' on TLC since we've been engaged."
After the wedding, the couple will have a reception at Walker's Steakhouse & Lounge before traveling to Miami where they will embark on a five-day cruise of the Caribbean.
They are still figuring out where they will live although Kristen said it will more than likely be Glenwood, IA.
The couple plans on enjoying life and each other for a couple of years before starting a family.


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Love your blog and everything it stands for, bvs nko? I love them scatter. Anyway I am in dire need of advice and help. I am having a bit of issues in my relationship. My chronicle is a bit disjointed cause at the moment I am so down and depressed I am currently on anti-anxiety pills.
I am 26 years old married with a baby (18 months and we've been married for two years), my husband is a medical doctor and he works in a different state from me, firstly my hubby will not allow me visit (I haven't visited in 1 year and 8 months, he comes home once every 2 weeks), he always uses the excuse that he stays in a one bedroom there and it can't fit I and the baby (which is kind of true) but I believe that as a family, if there is love we can manage for just three days to one week, but he never bulges.
Secondly, our communication is zero, he only calls to check on me and the baby vaguely (in fact when he calls I can already predict the conversation, it's very rote and boring). The one that even killed me is when he said to my face last Sunday when we had a little argument 'you know I don't talk to you so you don't have to worry' Stella I cried so much cause I felt so little or best put like a nuisance.
On the Saturday before the Sunday I wanted to have a Heart to heart with him, he refused saying he is studying, I insisted on talking even though he pretended to not be listening, but I continued telling him how I feel, all he said was if I wanted to divorce him I should say it, I was really shocked (though in the past I've mentioned such cause I am just so tired).
Thirdly, He also doesn't trust me, he accuses me of cheating every time. If I tell him I'm at my girl friends place sef it's war, he just wants me to be at home even though he won't call or even keep me company. It's crazy!!!
Fourthly, he is the sole provider in our home, though I am a graduate with 3 different degrees from Universities abroad, i only recently got a job to start in the new year. I live very decently cause he gives us a good life, but those things can't comfort me I need my man to love and appreciate me.
My home is far from sweet at the moment, he is 38 and I'm 26. We dated for two years though I and everyone in his family know he's reserved and doesn't talk too much I never knew it will deteriorate like this. He is a calm man and but when he is on the phone with his doctor friends he will be so excited and all chatty. So he has it in him he doesn't just want to give me that side of him.
I am so tempted to cheat but I can't because I am a child of God and one of those people that fear Gods wrath so much. Guys are always asking me out, because I am very pretty with a lovely shape and very humble and friendly personality so anywhere I step men are always on my case.
Just to clarify I am one of those that have people flocking them, many of my friends won't even do stuff without consulting me for advise so I'm not dumb or boring. I really don't know.
Finally, my hubby will never compliment me, it's almost like I don't exist even if I fish for it, he looks at me and says 'you are ok, or the outfit Is ok' (Ive gotten informal awards on being the fashionista of the year and all, so I really take care of myself, in fact on the side I do make up and dress people for events, so I'm not razz or anything)
How can a young vibrant lady live like this for the rest of her life? I am so tired, dear bvs please help me on what to do.
I really don't know why my hubby hates me so much maybe there's something I can't see, I am annoying too but just minimally like every woman and if we fight and he just begs me once or twice and I've moved on. I don't know what else to do, is there anyone In This situation or overcame such? please help me, I've contemplated suicide so many times because of this emotional torture. There is nothing as painful as being loved and appreciated by the world but not by the one person that matters the most.
Thanks my cyber-family for your anticipated help on this issue.


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Re: Common Household Remedies Request
It depends on whether or not your water heater (and house) blows up before he gets there. If it does, its criminal incompetence, if your house is still standing, its merely utter cluelessness.
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[I'm going to sticky this because I'm still looking for an answer. --lambert]
So, modified rapture on the hot water heater! The plumber came and installed it, and the electrician came and wired it up. However, the plumber did not "stub down the PT valve":
During times of considerable use, the water heater has a great deal of steam and moisture inside. This amount of steam increases the amount of pressurization in the heater. You may find that it rumbles or shakes, and this is a sign that it is near its pressure overload point. When it reaches this amount of pressure, the relief valve opens, allowing steam and moisture to escape, thereby relieving the pressure inside the heater.
So, the valve is there (as it should be) but the pipe that should allow the steam and moisture to escape is not. The question:
The plumber's guy is coming tomorrow, but how bad is this? Minor fuck-up, utter cluelessness? Criminal incompetence?
UPDATE The plumber's guy came, and "stubbed down the PT valve." There is now a nice copper pipe angling angling out from the pressure valve on top of the heat and then down to within a few inches of the ground. So at least they're responsive! But again, how bad is the error?
It depends on whether or not your water heater (and house) blows up before he gets there. If it does, its criminal incompetence, if your house is still standing, its merely utter cluelessness.
The valve is going to open so the house is safe; it's a question of where the water goes. And if I want the value leaking on top of the tank where corrosiion will happen, or if the leakage is drained off the with the pipe.
i am no plumber,but i believe it is piped to the floor so that if it ever does open it will not blow piping hot water into someones face, but rather onto floor.
I dont think it was any big deal even without the pipe going down to the floor. It is a safety feature that seldom is needed. When my plumber installed my new gas water heater he didn't install the pipe either. There is no sign that it has ever opened to relieved the pressure in two years of use. The whole idea of the thermostat settings well below the boiling point of water keeps the water from boiling and building dangerous pressure. Only if the thermostat fails to do its job, would the water overheat and pressure need to be relieved. I just got an insulating wrap for my waterheater and was thinking that I ought to get a piece of pipe and extend it down to near the floor after I put the wrap on. I'll get a plastic piece with pipe threads and look for a chunk of plastic pipe of the right diameter at the local ReStore. If I don't get it done for 6 months or a year, I'm not concerned.
That's exactly what I needed to know. And of course it's a fail safe for thermostat failure because -- and I know this! -- the water is set to 120°!
People do make mistakes, and if he put the valve in the danger isn't in explosion but someone maybe being scalded if they're standing in the way when it releases.
If they come out quickly and don't charge (because it's probably code even though half of homeowners probably don't have it), then let it go.
P.S. a Captcha, while being logged in on an account i've had for something like two years. Minor Fuck-up, utter cluelessness, criminal negligence? Oh, here i'll do another one just to post a fucking comment to a blog.
I'm experimenting with them. You've got no idea of the crap that's been clogging my mailbox and demanding to be processed, and I should be blogging and not doing that. Fortunately, some new stuff I installed cut it back dramatically.
They're kinda cute, actually, and way easier than the ones on Blogspot.
I want to lower the barriers to commenting a little and see how it goes. But too many knobs and switches on the back end of this site ;-) I flipped one the wrong way.
Now I can keep giving these guys work...


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WASHINGTON (AP) — Tea party fervor has surged and waned in the past four years, Occupy encampments are long gone from parks in the nation's capital, and the crowd for President Barack Obama's second inauguration figures to be significantly smaller than the record-breaking turnout of 2009.
But spectators can still expect the customary tight security long associated with the event — not to mention protesters advocating assorted causes.
City and federal officials are implementing measures intended to prevent calamities, such as a terrorist attack, and to address more mundane concerns, like slow-moving security lines and cold weather. Flight restrictions are in place in the skies over Washington, with extra security on the city's waterways. Spectators will be limited in where they may drive and what they can bring.
The Secret Service, the lead law enforcement agency for the Jan. 21 event, isn't revealing specific precautions, though tactics in the past have included trained sharpshooters, bomb-sniffing dogs, air patrols and surveillance cameras with feeds streaming into a command center.
"We have a very robust, but standard, package that we put together for something like this. There is not any tool that any of the agencies have that will not be employed," said U.S. Senate Sergeant At Arms Terrance Gainer, who is involved in the planning.
Inauguration preparation is a constant balancing act of ensuring airtight security while simultaneously moving massive crowds around the city.
Officials say they're determined to correct some of the logistical headaches of 2009, when some visitors complained of slow-moving, chaotic lines outside security gates and thousands of people with tickets to the swearing-in were left waiting in a tunnel below the National Mall. This year, organizers say, spectators will encounter more magnetometers to speed security lines, along with more — and earlier — signs to get people to their destinations.
"Our biggest concern is making sure that folks can get from wherever their buses are to the events they want to see, and back," said Chris Geldart, director of the District of Columbia's homeland security and emergency management agency.
City officials are expecting between 600,000 to 800,000 inauguration spectators, far fewer than the 1.8 million people who packed the Mall for the inauguration four years ago. But the security measures will look familiar.
Thousands of police officers will be visible. Many roads around the U.S. Capitol, the Mall and the White House will be closed to vehicles, with bridge traffic diverted in some locations. Some Metrorail stations will be closed, others probably packed. Backpacks, large signs, bicycles, glass containers and weapons are prohibited along the parade route. Anyone who wants to see the swearing-in ceremony from the U.S. Capitol grounds needs a ticket.
Included in the crowd will be those looking to experience history, but also organized demonstrations, an Inauguration Day fixture. In 2009, a smattering of protest groups lined the parade route but no major incidents were reported. Four years earlier, demonstrators against President George W. Bush jeered his motorcade and some tried to rush a security gate blocks from the White House. Police briefly locked down the area, trapping some 400 to 500 spectators.
Many of the demonstrators this year aren't necessarily conventional Obama administration opponents, but nonetheless say they feel let down by his first term. Their causes vary from abortion to military drone strikes to the nation's unemployment rate.
Participants in one demonstration, the Arc of Justice Coalition, will meet at Meridian Hill Park about 1 1/2 miles north of the White House and march toward the parade route while criticizing the Obama administration's use of unmanned drones to attack targets abroad and the "influence of corporations in our lives," said Malachy Kilbride, one of the organizers.
"What a lot of us are concerned about is that the only people who are opposing Obama are on the right," Kilbride said. "The point is that Obama is being criticized from the progressive liberal left side also."
Kilbride said the demonstration could draw a few thousand people, but the group had no plans to cause trouble.
The ANSWER Coalition, a peace and social justice organization, is staging a demonstration in a small area of Freedom Plaza, along the Pennsylvania Avenue parade route.
"We'll be highlighting the fact that such a vast (percentage) of the national treasury goes to wars and militarism rather than to meet human needs, so we're going to be demanding jobs and justice — not war and occupation," said Brian Becker, the group's national coordinator.
District of Columbia officials, including Mayor Vincent Gray, will use their reviewing stand along the parade route to highlight the local government's lack of budget autonomy, statehood and congressional representation — Delegate Eleanor Holmes Norton cannot vote on the House floor. The movement gained recognition this week when the White House announced that President Barack Obama's limousine will soon carry D.C.'s "Taxation Without Representation" license plate.
A sign on the reviewing stand, at the D.C. government building, will read: "A More Perfect Union Must Include Full Democracy in DC."
"We think the statement out there hardly will be missed," Gray said. "It will be understood, and we hope it will serve as a catalyst for further action."
An Ohio-based anti-abortion group, Created Equal, is staging a demonstration, also around the parade route, executive director Mark Harrington said.
"He'll swear to protect the rights of future pre-born children while at the time same defending the injustice of abortion," Harrington said of Obama.
Though the anticipated crowd will be smaller than 2009, Gainer said security plans will be equally vigilant. There's never been an assassination attempt at any inauguration, and there's no specific or even generalized threat that officials are aware of this year, he said.
"The biggest security concern is there's some state-sponsored threat or individual threat, but we're kind of concerned about that every day over here," Gainer said. "I don't want to say the inauguration is a routine security event for us. But in our business, it's pretty close to business as usual."
Gainer acknowledged, however, "What we have learned over these years is this is an attractive nuisance" for people looking to cause problems.


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Reviewed By tim f (Anderson, SC) Reviewed for a 2000 Chevy Blazer —6/5/2016 1:38 PM
Well made,more like original lights in quality, these are the 3rd brand I've tried, best ones yet, finally satisfied. Not going to make the mistake of using factory bulbs again. Using red led's looks sharp.


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Here's Your New Dancing With the Stars Lineup
Dorothy Hamill and Lisa Vanderpump, together at last!
Dorothy Hamill, Aly Raisman, and Andy Dick are among this season's contestants for Dancing With the Stars. ABC announced the full lineup this morning, though it is sadly without Bobby Flay. (And without Lance Armstrong. And Lindsay Lohan. And Ann Romney. Man, there were a lot of rumors this season.) Anyway, your actual contestants for this sixteenth ridiculous season are:
- Shake It Up's Zendaya Coleman (apparently that is a Disney Channel show!)
- Comedian Andy Dick
- National treasure Dorothy Hamill
- Comedian D.L. Hughley
- Baltimore Raven Jacoby Jones
- Singer Wynonna Judd
- Boxer Victor Ortiz
- American Idol alum Kellie Pickler
- General Hospital's Ingo Rademacher
- Olympic gymnast Aly Raisman
- Real Housewife of Beverly Hills Lisa Vanderpump
Cha cha cha cha, etc.


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Since my last post about the spice behind Spice (and other smoking mixtures such as Smoke, Serenity Now, K2, Sence, etc), it has been brought to my attention that some initial toxicology testing has been done on the synthetic cannabinoid JWH-018. Before we get down to the details however, here's some pretty weird background information — the sponsor and provider of these studies wishes to remain anonymous! Unfortunately, this makes the whole thing a lot less credible, but since this is the only information we have right now, let's hope someone else can verify these things at a later date. So far, one professor (who also wishes to remain anonymous) thinks these are real, but as of yet, no one is willing to put their name down on any kind of formal statement. If you, or anyone you know, has the relevant expertise to look over these studies, please drop me a line!
(Quick Update — A lot of people have been discussing and linking to this post, but there remains some suspicion that I have something to gain by saying the JWH-018 isn't that harmful. Firstly, JWH-018 is now illegal in the UK. Secondly, as I mentioned just above this, if I have got anything wrong, please pick me up on it! If it turns out my analysis of the data is incorrect, I will correct it!)
Feel free to invent your own conspiracy theories, but for now, let's take a look at the data. You can download the PDF documents in this Zip file [2.04 MB]
CYP450 Inhibition Assay
This first assay looks at the effect of a drug on specific enzymes in your liver. These Cytochrome P450 enzymes are responsible for metabolising the vast majority of drugs you might put in your body, so if you've got too much of one drug in your system (ie paracetamol/acetaminophen), then other drugs that are also metabolised by these enzymes (ie alcohol) may compete for these enzymes and so hang around in your system for longer. As you can imagine, it's important to understand how one drug may affect the metabolism of another, in case of any disasterous drug-drug interactions.
Results: JWH-018 will probably interact with the metabolism of other drugs, so more in vivo work is necessary.
hERG Binding Assay
hERG stands for human Ether-à-go-go Related Gene. This gene codes for a particular type of potassium channel found on heart tissue. This channel pumps potassium ions out of the heart muscle cells and are critical in coördinating the heart's electrical activity. Unfortunately, these channels are a prime target for drugs to bind to, disrupting their function. This can lead to "Long QT Syndrome", associated with fainting and can lead to sudden death, so you can see why these kinds of tests are important. Here's a typical ECG recording showing what's called the "QT interval" shown in blue, which lasts for longer than it should do if these channels are disrupted.
Results: JWH-018 does not interfere with these channels. That's a good thing.
Cytotoxicity Assay
This simple test essentially looks at how many cells die when you perfuse them with a drug. The more cells that die, the more toxic the drug.
Results: JWH-018 is not cytotoxic at low concentrations.
GreenScreen HC Genotoxicity Assay
This assay looks at how much a drug will interfere with our DNA. Typically, anything that damages DNA is bad news, being potentially carcinogenic, making the rationale behind this test glaringly obvious. This test was also performed in the presence of a fraction taken from liver cells, which will break down the drug. This not only checks if the drug will damage DNA, but also its breakdown products.
Results: JWH-018 does not damage DNA, so shouldn't give you cancer.
Rat Repeat Toxicity Assay
Guess what happens in this experiment. A number of renagade lab rats looking for a bad time are rounded up and promised free drugs (kind of like Pleasure Island from Pinocchio; that shit was scary!). The rats are then dosed up and observed. Initially, they appear lethargic (read: totally baked) but a few of them died at higher doses. This appears to be down to problems breathing rather than organ toxicity, but only affected the male rats, who appeared more sensitive to the compound. The drug didn't appear to accumulate in their systems either, but they did lose some weight, probably because they couldn't be arsed to eat. JWH-018 showed a huge potency and was found to be tachyphylactic (my new favourite word — it means that more of a drug is required to reach the same state following an initial dosage).
Results: According to FDA guidelines, the human equivalent dose is 0.016 mg/kg but it should be tested in other species before this can be seen as reliable!
Rat Pharmacokinetics
Data is collected on a number of different "pharmacokinetic" aspects of the drug, such as how it is absorbed, distributed throughout the body, metabolised and excreted, which can help with the design of future clinical trials.
Results: JWH-018 is distributed well throughout the rat's tissues. Metabolism and excretion are normal, with a plasma half-life of approximately 2 hours
Well, from the looks of these tests, JWH-018 seems to be pretty safe, but unless you want to piss off Ben Goldacre, it would be wise not to rely on this "test tube data" entirely. Also, like I said before, we don't know where this data has come from, clouding the issue even further.
Feel free to ask any questions in the comments.
Big thanks to Alfa @ Drugs-Forum.com for letting me know about these studies. You can read all about JWH-018 on their Drugs Wiki.


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SANDY, Utah — When Real Salt Lake selected Ned Grabavoy in the 2009 MLS Waiver Draft, they obviously saw something in the midfielder that his previous clubs in LA, Columbus and San Jose had not. Because if any of those three clubs could have foreseen the level Grabavoy is now playing, there is no way any of them would have let him get away.
Grabavoy is either on pace or has already set career highs in goals scored, assists and minutes played. Those stats show just what everyone else within the club has seen, the 10th-year veteran has been all over the field making all kinds of plays in helping the team to the best record in MLS. So what has changed for the 30-year-old midfielder?
"I think part of it is with the departure of Will Johnson and that Ned knew he was going to have to take a bigger role," said RSL coach Jason Kreis. "Ned knew — I didn't hesitate to tell him — he's a lockdown in the starting lineup for us. I think some of that has just brought some more confidence out in him.
"He's also had a change in his life with having children. The best year of my entire career was when I had my first child, so I think it changes you a little bit. It makes you become a little more intently focused on how to get the best you can out of the little time that you have to play professional soccer."
What does Grabavoy think of his coach's assertion that perhaps it was the birth of his children that helped make the change?
"Maybe, I am getting less sleep so I don't know if that helps," he joked to MLSsoccer.com. "Look, it probably took me a while longer to figure some things out off the field. Which maybe I wish I would have figured out before, but it is important. Diet, sleep, getting on the right schedule, not being out, all those things are important, what you put in your body. Now, those things are important to me.
"I don't want to play Saturday-Wednesday and then have Jason say, 'He can't play three games in seven days.' I can play three games in seven days. I don't want to be asked. I just want to see my name up on the board. At the end of the day, my only job is to make Jason's job, when he goes to write the lineup, I should make it so I'm the first name that he pencils in. I should be up there every game. That's my job, and if I'm up there, then I am doing my job."
With his off-the-field work, Grabavoy has become indispensible. It isn't often that a player actually attributes things physically to being improved once he gets older.
"I think I'm doing a lot of things the same, but I would like to think fitness wise I'm at the top that I've ever been," said Grabavoy. "It was a tough stretch there to play three games in eight days, but I was feeling pretty good there even toward the end the game. I think it probably is just that extra 10-percent fitness to be able to make three or four 40-, 50-yard sprints into the box to try to make a play. I find myself now getting one or two goal scoring opportunities a game, where as maybe in year's past, I didn't have that."
Perhaps another reason why Grabavoy has been able to put in those extra runs is something Kreis and the coaching staff have done this season.
"I feel really good, I feel healthy. It is probably a number of different things," said Grabavoy. "When I was younger — I'm not going to say I don't go 100 percent in training — but I think we have probably looked at some of the older guys and everyone's been smarter about the training staff, the coaching staff to not kill some of the guys that are playing major minutes for you in training every week so I can feel at the top of my game come game time."
Many people have said this is Grabavoy's career-best season simply because they look at the fact that he has scored five goals. But his teammate for the last five seasons Chris Wingert said that is unfair.
"Yes and no," said Wingert of this being Grabavoy's best season. "I get a little defensive about it because people put so much importance on goals, and clearly that's the name of the game, so for him to have five goals is big, but what people don't always realize is the amount of work it takes to play that position on our team is incredible.
"It's no surprise to see Will Johnson scoring more this year because he has more freedom. The amount of work that these guys do when they play in front of me, outside midfield, is incredible. It is such a demanding position the amount of running they do. It is just not physically possible to be in the box quite as much. Ned is not really an outside shooter, but he has done an incredible job of getting in positions in order to score goals this year, which we've needed."
Grabavoy echoed his teammates thoughts.
"It isn't easy in the diamond [midfield]," he said. "You have a lot of defensive responsibilities in the diamond. You are usually playing against a winger who is not tracking back to double like we do. It is difficult sometimes in that diamond."
Wingert said although it has been better this season, Grabavoy hasn't always received the type of recognition he probably deserves.
- Get more Real Salt Lake news at RealSaltLake.com
"I'm glad he is finally getting his due because for me, it's a shame that he wasn't an All-Star this year, you could make the case he was the MVP of our team, and we were in first place at the time," said Wingert. "He has just been awesome and I'm just glad that people are starting to realize it."


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If you know any good jokes about programmers and tech people post them here
margarine and eggs
Wife sends her husband programmer to the store:
- please buy 1 package of margarine, and if they have eggs - buy 10
Husband comes back home with 10 packages of margarine. Wife gets angry:
- why so much margarine?!?
- you've said it yourself - to buy 10 if they have eggs.


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This Item is now Sold Exclusively through our Distributor MAGG Performance
2007-2013 Chevrolet Silverado Duraflex G-Force Hood – 1 Piece
Fits the following models: Fits All Models, Base Model, LS, LT, LTZ
As with all fiberglass products, especially at this price point, it WILL require PROFESSIONAL installation and body work (cleaning up in some places from the mold, block sanding, etc… any competent body shop should have experience in this).
MAKE SURE TO INSPECT THE PACKAGE UPON DELIVERY. If there is any damage in shipping you must refuse it when it arrives. If it is damaged WE WILL REPLACE IT AT NO COST TO YOU. If you wait a week to take it out of the box only to discover it is cracked in shipping we no longer have the option of replacing it for you.
We try to keep these in stock but please allow 2-3 weeks for shipping to be safe.
If you find it at a lower price CONTACT US FIRST and we will try and work with you (no guarantees as other vendors may get better discounts than we do, also the shipping price is non-negotiable unless you would like to pick it up in Fullerton, CA). You must contact us BEFORE you buy though.
Thanks for looking!
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Finally the truth about Sen. Mitch McConnell is coming out. With all the money from corporations and billionaires such as the Koch Bros., they are trying to buy the election. So far, it is not working. Even with all the dishonest ads, trying to connect Secretary of State Alison Lundergan Grimes to our President, Sen. Harry Reed and saying she is against coal, it isn't working, because truth wins out.
We are being bombarded with campaign ads that assault our intelligence. A single glance at the litter on the airwaves and in our mailboxes would have us believing that President Obama is on the ballot. He's not. Like him or not, he remains President of the United States for two more years – and will not be on the ballot again.
Our 24th District has an opportunity to elect Alex LaRue as state representative. Alex will bring a fresh point of view and needed business and financial experience to the Kentucky General Assembly.
Each election season, there is invariably a major issue or two that that becomes so distorted by the political process that it becomes almost unrecognizable. This year, the state's road funding is at the top of the list. Many of you have received political mailings that the proposed House budget raised the fuel tax. Nothing could be further from the truth.
I would like to reach out to the voters in District 2 before the Nov. 4 election.
Angela Carter is an intelligent, dedicated teacher and leader who cares deeply for the education of all children and would serve our district best as a member of the school board.
By Davette Swiney
President/CEO of Central Kentucky Community Foundation
Increasing the caliber of our community starts with a commitment to affecting the lives of individual citizens.
With recent rain showers and storms rolling through Kentucky as cool and warm weather mix, along with getting into the heart of football season and leaves turning and beginning to fall, autumn is officially here. Along with that, we are very close to an important election day as we go to the polls to choose our next U.S. Senator as well as many local and state officials who will shape policy over the next two to four years. Again, I want to encourage you to exercise your right to vote on Nov. 4 or call your clerk about voting via absentee ballot in the case you will be out of town.
This month, I will begin visiting schools throughout the district as part of the America's Legislators Back to School Program. My presentation includes teaching our form of government and explaining how our representative democracy works. The program is actually a nationwide event and is made available by the National Council of State Legislatures.
It's that time of year. The time when no matter where you go, you see it, even if you think it's too early to worry about.
That's right, it's political season ... although sometimes I wonder if it ever ends.
For many of us, politicking has been invading our mailboxes of late, too.
Over the last few weeks and months, I've come home to multiple pieces telling me that: - - Mitch McConnell is great for Kentucky
- McConnell is just another Washington insider
Born, raised in Kentucky
To the people of Kentucky, I am proud to be a fifth or sixth generation Kentuckian. I'm proud to be bred, born and raised a Kentuckian. My father's family, the Perrys, have been in Stamping Ground since the 1790s. My mother's family, the Abrams, has been in Frankfort since the 1800s. I am a Kentuckian from the top of my head to the bottom of my feet. So this is how I feel about the politicians.
By Jama Watts
Guest columnist
In the state of Kentucky, October is Archives Month, making it the perfect time to break out the shovels and dig up those ancestors! From 5- 7 p.m. Thursday, Oct. 16, the library is hosting a genealogy workshop with yours truly.
The wars military men and women fight on America's behalf are not always on the battlefield, or at least not what most of us envision when we hear the word "battlefield." I was vividly reminded of that when I heard the news last week that more than 60 airmen and women from Kentucky's Air National Guard were preparing to depart to Senegal. Their mission is to help establish a cargo-processing hub for Operation United Assistance, the international effort to battle Ebola in West Africa.
Switch to McDonalds and Grimes
Burger King recently moved their national headquarters to Canada from the United States. Senator Mitch McConnell failed again to close tax loopholes for when corporations move out of the country.
Each fall, the National Census of Domestic Violence Services takes a real-time, 24-hour look at the true impact domestic violence has on our country.
Nearly 90 percent of the United States' care and prevention programs participate, including Kentucky's. According to the survey's latest findings, they provided shelter to more than 36,000 victims on Sept. 13, 2013, the latest year in which information is available, and another 30,000 received non-residential help ranging from counseling to legal advocacy.
By Keith Anderson
Director of News, ECM Publishers
There are hundreds of beautiful towns in the United States. And each of them has a claim to fame. Whether it's the Fire Hydrant Capital of the world in Albertville, Alabama, the giant statue of Paul Bunyan welcoming visitors to Brainerd, Minnesota, or the giant ice cream sundae statue in LeMars, Iowa, every city has a desire to be known for something.
By Robert M. Williams, Jr.
National Newspaper Association President
What do you care most about in life?
Most of us would put family at, or near, the top of such a list. Friends would be there. So would our jobs or businesses, our livelihoods. Our homes. Maybe our pets. Our hobbies and pastimes. Add in those around us: Neighbors, the community, etc.
That's our world, our "sphere of influence." Whatever happens to those who inhabit that place in our hearts and lives means something to us.
We monitor.
It's a tradition for this newspaper to write an editorial the week after Marion County Country Ham Days to praise the Chamber of Commerce and the countless volunteers that make the annual fall festival such a huge success.
And, each year, it seems the festival continues to grow.
Copyright © 2018
The Lebanon Enterprise is your source for local news, sports, events, and information in Marion County and Lebanon, KY, and the surrounding area.


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When last we left them, the O.C. ladies were knee-deep in hairspray, legwarmers and inappropriate lace at Bunco. Bravo gave us the okey-doke with a snoozer of an episode, but all is forgiven with the epic blowout that ensues tonight! After inviting the drama and then stirring it up, Tamra is so elated that she declares "I think I need to eat some carbs!" so you know it must have been some kind of party!
We open with the dudes lookin' like ladies: Househusbands Slade, Eddie and Terry show up at the Bunco party in full-out wigs and spandex! Turns out Terry's late brother was the lead singer of Quiet Riot. Small world, this California.
If you think Slade has major marbles showing his face at this party after his Improv performance, then you are in for a treat: That was just the beginning! Slade actually has the nerve to start in with Ricky. (Slade's mullet got in the way, and he mistook Ricky for Vicki. But don't worry – he gets to Vicki in short order.) At one point in his tirade, Slade refers to Vicki derisively as "this" and that, my friends, is when the ish hit the fan. Under the weight of Slade's accusations, Vicki "exits stage left" but comes right back in for more. And Gretchen is just the one to serve it up. She calls Vicki out for accusing Slade of being a deadbeat dad when she is dating a man who has been jailed for not supporting his children. After screaming a lame defense to this, Vicki leaves the party for good this time.
While she will later explain to Vicki she was "in a fog" at this point of the party, Tamra does see clearly enough to call Alexis out for her "medically necessary – yeah, right" nose job. Honestly, I don't see why everyone keeps getting on Alexis about this. I mean – I know why I get on her about it, but I live in Baltimore. These chicks live in Orange County – instead of ridiculing her, shouldn't they be checking to see what gifts Alexis registered for on Rodeo Drive for her "new nose" shower?! Speaking of the nose job heard 'round the world, in this episode we get the pleasure of watching Alexis check in for rhinoplasty and check out of reality. Can we get this anesthesia to go?
Tonight's superlatives are all about hair bands and headbands:
The Milli Vanilli Award for Authenticity: Heather
Blame it on the rain or blame it on the Botox, but the perma-shocked expression that Heather wears in every episode is wearing thin. She acts so surprised at the drama and the arguments. C'mon Heather – it's Real Housewives! You knew what you were signing up for – drop the feigned astonishment and get on board or get out!
Toto-ly Off Base: Vicki
When her hypocrisy is laid out to her in no uncertain terms, Vicki's response is that Gretchen will understand "when a baby comes out of her vagina." In addition to this statement being a just a tad too gross clinical, it is also inaccurate. You don't have to be a mother or an obstetrician to know that Vicki is dead wrong on this one. Either ease up on Slade or bring the hammer down on Brooks. You can't have it both ways, Vick.
Toto-ly On Point: Gretchen
I am as skeptical of her judgment (as evidenced by her new friendship with Tamra) as anyone else, but Gretchen held it down this episode. She called everything like she saw it and she was right about it all – from Vicki's hypocrisy to Alexis' histrionics, she never wavered. Keep on keepin' on, Gretch!
Best Delivery of a Huey Lewis and the Newsflash: Briana
"Nothing is ever about me or anybody else when it comes to my mom – it always ends up being about her." From the mouths of babes …
Do you have '80's PTSD? Me, too. Let's talk it out in the comments below and be sure to follow me on Twitter @MutesVoice.


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reminiscing when the la raiders was in my home snap back fitted in my uncles dome and i don't condone dick riding im addicted to #westsiding
please add my social group and show support
Yeah, It was a really boring fight Rhodes is a joke, I dont know how he had 3 belts. Golden Boy is babing Alvarez, I bet if they give him a good fighter he would KO alvarez. Oh well we just keep watching what they give us... canelo is a joke by the way, other fighter would have KOed Rhodes...
Did you see the fight bruh?
Checkout da boxing forum when you get a chance bruh.
Vets Minimum


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Neurologists actively research causes, diagnostic tests and new treatments for many brain and blood vessel conditions (cerebrovascular diseases). Doctors conduct research and review medical histories to learn how diseases progress, how to treat them and which treatments may be most appropriate for people. Read more about research in stroke and vascular disease.
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What Foods Are Always In Your Fridge? The Fall 2009 Kitchen Cure
As the Fall Kitchen Cure progresses, we are seeing a lot of your refrigerators, freezers, and pantries. It's always a fascinating anthropological thing to peek in someone's else's fridge. We're curious: among the cleaning and de-cluttering, what are the things that stayed in the fridge, and what are the things that are always there?
What's always in the back of your fridge, ready to be used? Here are a few things always on hand in mine:
• At least half a dozen jams and marmalades
• Miso paste
• Ghee
• Butter and eggs
• Soy sauce
• Sesame, walnut, and other nut oils
What about you? What survived the Kitchen Cure purge? What always stays in your fridge?
Related: Tips for Organizing a Refrigerator and Freezer
Join the Fall 2009 Kitchen Cure.
It's easy and free.
Here's the assignment for this week; you have until Friday to get it all done!