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CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene (CASPALLO)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00710892
Recruitment Status : Active, not recruiting
First Posted : July 8, 2008
Last Update Posted : October 4, 2017
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Patients are being asked to participate in this study because they will be receiving a stem cell transplant as treatment for their disease. As part of the stem cell transplant, they will be given very strong doses of chemotherapy, which will kill off all their existing stem cells. Stem cells are created in the bone marrow. They grow into different types of blood cells that we need, including red blood cells, white blood cells, and platelets.
We have identified a close relative of the patients whose stem cells are not a perfect match for the patient, but can be used. This type of transplant is called "allogeneic", meaning that the cells come from a donor. With this type of donor who is not a perfect match, there is typically an increased risk of developing graft-versus-host disease (GvHD) and a longer delay in the recovery of the immune system. Seventy to ninety percent (70-90%) of people who receive unchanged marrow or stem cells from this type of donor will develop severe GvHD.
GvHD is a serious and sometimes fatal side effect of stem cell transplant. GvHD occurs when the new donor cells recognize that the body tissues of the patient are different from those of the donor. When this happens, cells in the graft may attack the host organs, primarily the skin, liver and intestines, causing severe rashes, diarrhea, liver disease, and even death. GvHD is caused by a type of immune cell in the graft called T cells. Because there is a high risk of GvHD with the type of transplant the patient will receive, we will selectively remove the T cells from the graft that the patient will receive. This process, which is called "CD34 selection", is discussed in more detail in the separate consent form for the transplant.
While this stem cell selection procedure will reduce the risk of GvHD, it will also result in slower recovery of the immune system. As the immune system is responsible for fighting infections in the body, a longer recovery time after a transplant means that the patient may be at increased risk for infections which can become life threatening. In some patients, the immune system can also fight leukemia cells and reduce the risk of relapse.
In the laboratory, we have seen that cells made to carry a gene called iCasp9 can be killed when they encounter a specific drug called AP1903. To get the iCasp9 into the T cells, we insert it using a virus called a retrovirus that has been made for this study. The drug (AP1903) that will be used to "activate" the iCasp9 is an experimental drug that has been tested in a study in normal donors, with no bad side effects. We hope we can use this drug to kill the T cells. Other drugs that kill or damage T cells have helped GvHD in many studies. However we do not yet know whether AP1903 will kill T cells in humans, even though it has worked in our experimental studies on human cells in animals. Nor do we know whether killing the T cells will help the GvHD. Because of this uncertainty, patients who develop significant GvHD will also receive standard therapy for this complication, in addition to the experimental drug. We hope that having this safety switch in the T cells will let us give higher doses of T cells that will make the immune system recover faster. These specially treated "suicide gene" T cells are an investigational product not approved by the Food and Drug Administration.
|Condition or disease
|Acute Lymphoblastic Leukemia Non-Hodgkin's Lymphoma Myelodysplastic Syndrome Chronic Myeloid Leukemia
|Biological: Allodepleted T Cells
|Phase 1
Because the patient will receive cells with a new gene in them, they will be followed for a total of 15 years to see if there are any long-term side effects of the gene transfer.
Before the conditioning treatment for the transplant, we collected 30 mL (6 teaspoonfuls) of blood from the patient, which we made into a cell line that grows in the laboratory by mixing the blood with a virus called EBV. Some of the cells from this blood were mixed with T cells from the blood stem cell donor, to stimulate cells that might cause GvHD. We then added an investigational agent called RFT5-dgA. The RFT5-dgA helped to get rid of donor T cells that might cause GvHD. To get iCasp9 into the remaining T cells, we have to insert the iCasp9 gene into these cells. This is done with a virus called a retrovirus that has been made for this study, and will carry the iCasp9 gene into the T cells. The virus also has another gene called CD19, which will make the cells express the CD19 protein on their surface. We will not inject the virus directly into the patient, but only into the special T cells we have made in the laboratory. After we have put the virus into the cells, we will select the T cells that have CD19 on their surface, so we know these cells will also have the iCasp9 gene. We will perform tests on the specially treated cells before giving them to the patient, to ensure they only carry the iCasp9 gene, and not the virus itself. This should ensure that no virus can come out of the cells and infect other cells in the body.
To prepare the body for transplantation, the patient will be given high-dose chemotherapy. Further discussion of the treatment plan for the stem cell transplant will be discussed with the patient separately, and they will sign a separate consent form.
If the patient is doing well after the transplant, and they do not have serious GvHD, they will be eligible to receive the special T cells from Day 30 to 90 post-transplant. The specially selected and treated T cells will be given by vein, once. The cells will be given between Day 30 and day 90 after the patient receives their stem cell transplant. We will give special medicines before the IV starts to help prevent allergic reactions that might occur. Because there is a possibility that the specially treated T cells can cause or worsen GvHD, we will not be able to give these cells if the patient already has significant GvHD.
If the patient develops GvHD after being given the specially treated T cells, we will prescribe the new drug that has been shown to kill cells carrying iCasp9. The drug's name is AP1903. It has been tested in normal healthy volunteers, and has not caused any bad effects, but it is not approved by the FDA. Although the drug is not approved by the FDA, the FDA has allowed us to use the drug for this study. This drug will be given as a 2-hour intravenous infusion. We will take 10 mL (2 teaspoonfuls) of blood on days 2, 4, 7 and 14 after the infusion to check if the drug has been successful in killing the specially treated cells. If the patient has mild GvHD, and if the GvHD does not get better with AP1903, we will give the patient additional medicines that are usually used to treat GvHD. If the patient has serious GvHD, we will immediately give additional medicines that are usually used to treat GvHD, as well as AP1903. In some cases though, GvHD does not respond to treatments.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|10 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|CASPALLO: A Phase I Study Evaluating the Use of Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene After Haploidentical Stem Cell Transplantation
|Study Start Date :
|December 2008
|Actual Primary Completion Date :
|November 2011
|Estimated Study Completion Date :
|July 2026
Experimental: Dose Level 1-3
Administration of suicide gene-modified allodepleted T cells.
Biological: Allodepleted T Cells
Dose Level 1 = 1 x 10e6 T cells/kg; Dose Level 2 = 3 x 10e6 T cells/kg; Dose Level 3 = 1 x 10e7 T cells/kg.
Patients may be enrolled at the next dose level of T cells when all patients at the previous dose level have reached Day 42 post-T cell infusion without unacceptable toxicity.
- To determine the maximum number of suicide gene-modified allodepleted donor lymphocytes that can be given to recipients of haploidentical stem cell transplants that will result in a rate of Grade III/IV GVHD of 25% or less. [ Time Frame: 45 days ]Maximum tolerated dose of suicide gene-modified allodepleted donor lymphocytes up to a total of 1 x 10e7/kg per dose.
- To evaluate the biological effects of administration of AP1903, a dimerizer used to activate the suicide gene mechanism, and its clinical effects in patients who develop GvHD. [ Time Frame: 1 year ]
- To analyze the contribution of the gene-modified cells to immune reconstitution in these patients by measuring their survival, persistence and expansion. [ Time Frame: 15 years ]
- To measure the overall and disease-free survival at 100 days and at 1 year post-transplant. [ Time Frame: 1 year ]
- To obtain preliminary information on whether subjects receiving additional doses of cells show a cumulative rise in the percentage of circulating gene-modified cells. [ Time Frame: 15 years ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|up to 65 Years (Child, Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
At the time of transplant:
A. Patients (up to 65 years of age) with:
- ALL or high grade NHL that is Stage III or IV and has relapsed or is considered to be primary refractory disease.
- Myelodysplastic syndrome.
- AML after first relapse or with primary refractory disease.
- Hemophagocytic lymphohistiocytosis (HLH); familial hemophagocytic lymphohistiocytosis (FLH); viral-associated hemophagocytic syndrome (VAHS); patients with severe chronic active Epstein Barr virus infection (SCAEBV) with predilection for T or NK cell malignancy; X-linked lymphoproliferative disease (XLP)
B. Lack of suitable conventional donor (i.e. 5/6 or 6/6 related, or 5/6 or 6/6 unrelated donor) or presence of a rapidly progressive disease not permitting time to identify an unrelated donor.
At the time of allodepleted T cell infusion:
- Engrafted with ANC greater than 500.
- Must have greater than or equal to 50% donor chimerism in either peripheral blood or bone marrow, or relapse of their original disease.
- Life expectancy greater than 30 days
- Lansky/Karnofsky scores greater than or equal to 60
- Absence of severe renal disease (creatinine greater than 2X normal for age)
- Absence of severe hepatic disease (direct bilirubin greater than 2 mg/dL, or SGOT greater than 200
- Oxygen saturation greater than 94% on room air
- Patient/Guardian able to give informed consent
At the time of transplant:
1. Pregnancy*
At the time of allodepleted T cell infusion:
- GvHD
- Severe intercurrent infection
- Pregnancy*
Other investigational drugs in the prior 30 days
- Pregnancy test only required for at-risk individuals, defined as female patients of childbearing potential who have received a reduced-intensity conditioning regimen.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00710892
|United States, Texas
|Texas Children's Hospital
|Houston, Texas, United States, 77030
|The Methodist Hospital
|Houston, Texas, United States, 77030
|Principal Investigator:
|Malcolm K Brenner, MD
|Baylor College of Medicine
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Malcolm Brenner, Principal Investigator, Baylor College of Medicine
|ClinicalTrials.gov Identifier:
|NCT00710892 History of Changes
|Other Study ID Numbers:
|First Posted:
|July 8, 2008 Key Record Dates
|Last Update Posted:
|October 4, 2017
|Last Verified:
|October 2017
|Studies a U.S. FDA-regulated Drug Product:
|Studies a U.S. FDA-regulated Device Product:
Keywords provided by Malcolm Brenner, Baylor College of Medicine:
suicide gene-modified allodepleted donor lymphocytes
given to recipients of haploidentical stem cell transplants
Stage III
Stage IV
Myelodysplastic syndrome
AML after first relapse
primary refractory disease
Hemophagocytic lymphohistiocytosis (HLH)
familial hemophagocytic lymphohistiocytosis (FLH)
viral-associated hemophagocytic syndrome (VAHS)
Severe chronic active Epstein Barr virus infection (SCAEBV)
T or NK cell malignancy
X-linked lymphoproliferative disease (XLP)
Additional relevant MeSH terms:
Myelodysplastic Syndromes
Lymphoma, Non-Hodgkin
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia, Lymphoid
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pathologic Processes
Neoplasms by Histologic Type
Bone Marrow Diseases
Hematologic Diseases
Precancerous Conditions
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Leukemia, Myeloid
Myeloproliferative Disorders
Self-Injurious Behavior
Behavioral Symptoms


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(visited by Mike LeBlanc)
10-Jul-2001 -- I first visited www.confluence.org in February of 2001, and noticed that the nearest point to my house (50N, 97W) had not been visited. Alas, by the time I got hold of a reliable GPS unit (several months later), it had already been visited. I decided to find another, and noticed that this one lay just to the west of where my job often took me. Even though it is a secondary point, I decided to give it a try.
This confluence point is about 20 km west of the town of Elie, and about 5 km north of the Trans Canada Highway, the main east-west corridor through the whole country. Heading north on Route 430, I passed several "mile roads" leading off to the east and west. Taking the third mile road east brought me 500 meters north of my destination. As I was getting out of my truck, a farmer rolls by and asks what my purpose was. I tried to explain to him what the project was all about. He seemed a bit perplexed, asked me "are you a land surveyor?", and when I said that yes, that was pretty close to what I was doing, he said I could proceed, but not to destroy any crops.
I headed south through a carrot field (rare in this area, where the main crops are wheat and canola) but after 150 meters I found my path blocked by a ditch filled with about three feet of water. Back to the main road, and another path along a tree belt brought me pretty darn close, just 100 meters east of the point. I had to walk carefully through the crops (no longer carrots, but pumpkins) and finally I found it. Out comes the digital camera ....click click click. My first confluence point visited. Hopefully I can visit another (49N 97W) on the Canada/US border in a few days.

subset: commoncrawl


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CHARLOTTE, N.C. (AP) — Ten people who identified themselves as illegal immigrants are under arrest for blocking an uptown intersection in Charlotte, N.C., near the site of the Democratic National Convention.
Charlotte-Mecklenburg Police arrested the protesters late Tuesday afternoon during what officials described as a nonviolent act of civil disobedience. The five women and five men who staged the sit-in are members of a group calling for comprehensive immigration reform.
Police did not confirm the protesters' immigration status or say whether they would report them to federal authorities. It is the policy of the Mecklenburg County Sheriff's Office to report all detained illegal immigrants.
The group identified one of the protesters as an illegal immigrant from Chicago named Rosi Carrasco, who said she wanted to set an example for her two daughters by protesting mass deportations.


text:
Click here to print
URL: http://www.tbo.com/travel-beaches/disneys-oldest-cruise-ship-magic-gets-a-makeover-b82483896z1
Disney's oldest cruise ship Magic gets a makeover
By The Associated Press
Published: April 26, 2013
Disney Cruise Line's oldest ship, the Magic, is getting a makeover, with a new water slide and children's area themed on Marvel Comics superheroes, the company announced Friday.Other changes when the ship goes into drydock in Spain this fall include redesigning cabins, dining rooms, play spaces, and adult areas like bars and clubs. Changes will include upgrading audio technology and lighting and retheming decor.Disney Magic launched in 1998. The new slide, called AquaDunk, is similar to thrill rides that already exist on Disney's newest ships, the Dream and Fantasy.Fran Golden, a veteran cruiser who blogs for Porthole Cruise News, predicts that the new Marvel's Avengers Academy will be a big hit. "What kid can resist hanging with Captain America, Iron Man and Thor?" she said.


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Falling a game short of the NBA Finals last season, the clear goal for the Indiana Pacers is the No. 1 seed in the Eastern Conference and the home-court advantage that comes with it.
Keep this up, and they will have the best record in the whole league.
Paul George scored 24 points and the Pacers improved the NBA's only undefeated record and the best start in franchise history to 7-0 by beating the Brooklyn Nets 96-91 Saturday night.
David West added 18 points and hit the clinching free throws for the Pacers, who won their first six games in 1970-71, when they played in the ABA. They have the longest winning streak to open an NBA season since both the Lakers and New Orleans were 8-0 in 2010-11, according to STATS.
"I really don't get too caught up in the historical value of it, other than we're ahead of the race," Pacers coach Frank Vogel said. "We're trying to get the 1 seed to put ourselves in the position come playoff time with the best chance to come out of the East."
Roy Hibbert finished with 15 points and 11 rebounds, and Lance Stephenson also scored 15 points.
"We executed. That's the maturity for this team," George said. "Years ago we would have lost that game. We would have lost this game tonight just on not making shots and not executing and getting guys in spots to be aggressive at. But we're growing as a team. We're getting mature and we're finding ways to win games."
Deron Williams and Joe Johnson each had 17 points for the Nets, who fell to 2-4 and lost at home for the first time this season. Brook Lopez scored 16 and Paul Pierce had 15.
"We're just learning to play together. We didn't have everybody healthy for training camp and we're all coming together and trying to win a championship and it doesn't happen overnight," said Williams, who added 10 assists but had a costly late turnover and committed what he called a "stupid" foul on George Hill's 3-point attempt down the stretch.
"We're not panicking, we know it's going to come together, we're confident that we can overcome these little struggles and we're going to stay together no matter what's happening on the outside."
Brooklyn trailed by 10 midway through the fourth quarter, but got a 3-pointer from Pierce that bounced on the rim at least four times in a spurt that cut it to 94-91, and they got the ball back after George threw away a pass with 20 seconds left. But Johnson was just long on a 3-point attempt with about 11 seconds to go and West grabbed the rebound and hit both free throws after being fouled.
Vogel said the Pacers have made winning the East their priority after they lost Game 7 of the East finals on the road in Miami. The quick start has them well on their way.
"We're just going out, playing the game," George said. "We feel very prepped for the game. Everybody is dialed in. We're not worried about keeping the streak alive, we're just worried about going out there and playing our hardest and winning a ballgame."
Indiana beat Chicago and Brooklyn, two of the top teams in the East, this week. The Pacers brought back their starting five and improved their bench, realizing that gives them an early advantage over teams like the Bulls and Nets that made changes since last season.
"Can't take nothing away from Indiana. They're a pretty good team right now and we're still a team that's kind of learning on the fly in game-time situations," Johnson said.
The Pacers opened an early nine-point lead that the Nets wiped away thanks to a strong performance by their reserves. Brooklyn already had nine players score midway through the second quarter and took a 46-44 lead into halftime after Lopez's jumper with 11 seconds left.
Indiana, which has trailed at halftime in six of its seven games, then outscored Brooklyn 28-21 in the third quarter.
The Nets were without reserve Andrei Kirilenko, who has battled back spasms this season and woke up hurting Saturday.
NOTES: Pacers president Larry Bird was in Terre Haute, Ind., on Saturday, where Indiana State unveiled a statue in his likeness before its season-opening game. Bird led the Sycamores to the 1979 NCAA championship game. ... Indiana snapped a four-game losing streak against the Nets.
Follow Brian Mahoney on Twitter: http://www.twitter.com/Briancmahoney


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Sydney Hills Outdoor Cinema presents....
The Commuter Tickets
6:30pm, Thu 15 February, 2018
Castle Hill Showground, NSW
This event has passed and sales are now closed
Event Details
Sydney Hills Outdoor Cinema
Gates open @ 6.30pm. Film to commence from 8.00pm.
For one of the best seats on the lawn, SMOOTH VIP seating offers premium deck-chair seating on arrival and an all-inclusive package ($32), plus a Twisted Frozen Yoghurt Cup included!
Making its debut for the fourth season of Sydney Hills Outdoor Cinema is the all new CABANA CLASS, the ultimate in relaxation and luxurious viewing. Lay back under the stars in your very own king size cabana suite for up to four people ($150) including blankets, pillows and a private butler service catering to all your food and beverage needs.
Looking for something special for you and your friends or family?
Why not hire one of our exclusive VIP Bell Tents, the perfect combination of privacy, comfort and style (max 8 people).
No need to queue up for food or drinks with this option; your private butler will place all of your food and beverage orders on your behalf and deliver them to you at your tent.


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After much thought on what weapon to create i am now thinking of a Twashtar.
I have already done the 3 x weapons, 3 x triple stars, 3 x serra...
Before progressing further and commiting to any specific path i wanted to know if it is possible to duo or dual box Glavoid and if so how easy/hard is he... and where it is best to stand etc...
I was thinking of doing it 1 x BLU and 1 x RDM, is that a good choice?
If there is any advice on positioning and atma choice then please let me know, and ofcourse let me know how tough it is to duo please... ive only beat him once along time ago in an alliance for the win.


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When Ruben Bermudez, 31, found out that he had HIV more than a decade ago, he didn't want to take his medicine. He went on treatment for a few weeks, but said the intensive pill regimen made him feel dizzy.
He stopped treatment and tried to ignore the diagnosis, moving to Florida from Washington in pursuit of sunshine. In 2008, he learned that one of his best friends died of a brain tumor that couldn't be treated because his immune system has been debilitated by AIDS. Bermudez realized that his only chance at a relatively healthy life would depend on taking pills daily.
"With his passing I decided to wake up and take control of my health and my life," Bermudez says. "Because at that point my HIV was spiraling way downhill. I should have been dead."
But the pills for HIV that he's taken daily since then have come with a hefty price tag. Monthly HIV treatment regimens range from $2,000 to $5,000 — much of it for drugs. With the life expectancy for HIV patients increasing, the lifetime cost of treatment in today's terms is estimated at more than half-million dollars. And while many people qualify for public assistance programs, staying eligible for support is a constant balancing act.
According to the Centers for Disease Control and Prevention, around half the people diagnosed with HIV in the U.S. don't receive regular health care. Of those who do, 42 percent receive Medicaid and 24 percent are uninsured.
People who are uninsured can still qualify for health services through the federally funded and state-run Ryan White Care act, which pays for medication through the AIDS Drug Assistance Program, or ADAP.
While the Obama administration released $79 million in funding for ADAP last week — eliminating waiting lists in 10 states — the program's support has fluctuated with each annual congressional appropriations process.
Each state has an eligibility process to receive ADAP support, and Murray Penner, with the National Alliance of State and Territorial AIDS Directors, explains that in many places the income cut-off limit for aid is $22,000 annually.
"Individuals that are receiving their drugs for free through a program like ADAP or through Medicaid," he says, "are really concerned about earning more than what would then be eligible for that program."
For Bermudez, making sure he remains eligible for assistance with his HIV care has meant refusing offers of full-time employment and raises.
Still, he's grateful to have the support. "I'm really lucky to have those programs available to me, because without them I probably wouldn't — I would not — take medication," he says. "Because I would not be working just to pay for my medication. I probably couldn't even afford it."
Medicaid's recent expansion under the Affordable Care Act may also make it easier for people living with HIV to pay for care, and many hope that with patents expiring on vital drugs in the coming years, cheaper generics may bring down the price.
Expanding access to care has implications beyond treating the virus in the person – public health experts say it's also critical to stopping the disease from spreading. People taking AIDS drugs are much less likely to transmit the virus to someone else, which ameliorates the long-term burden to public assistance programs.
"When we can avert HIV infections," says David Holtgrave, a professor at the Johns Hopkins Bloomberg School of Public Health. "We're not only saving lives. We're also saving dollars as well."
Bermudez, whose health has stabilized since he started taking medications four years ago, hopes to eventually be able to buy private insurance and pay for his drugs himself.
"Hopefully in the future it would available at a reasonable cost for everyone that is working, so that they won't have to do the things that I had to do — to quit jobs or to lie about income or just cover it up or anything like that," Bermudez says. "Because it has to be a way of life that's comfortable for everybody."
The International AIDS Conference wraps up today here in Washington. All week, the discussion has focused on getting people treatment from the moment they're infected with HIV. Studies show that can improve health and dramatically slow the spread of the virus.
The treatment is expensive. In the U.S., only about half the people living with HIV can afford it. The federal government is trying to make treatment more accessible, as we hear from reporter Jessica Camile Aguirre.
JESSICA CAMILLE AGUIRRE, BYLINE: Ruben Bermudez didn't want to start taking HIV medication. He was diagnosed with the virus in 1999 when he was only 18 years old. After a few weeks on treatments that he said made him sick, he stopped taking them.
RUBEN BERMUDEZ: I was a young guy. I was having fun, going and partying, going to clubs, living a normal teenage young adult life and that's all my focus was.
AGUIRRE: But, when his best friend Vaughn died with AIDS after ignoring his HIV diagnosis, Bermudez decided to go on treatment. He started taking medications in 2008, which were paid for through Medicaid and something called the AIDS Drug Assistance Program, or ADAP, a state-run program funded by the federal government.
BERMUDEZ: I'm really lucky to have those programs available to me because, without them, I probably wouldn't - I would not take medication because I would not be working just to pay for my medication. I probably couldn't even afford it.
AGUIRRE: Almost half the people living with HIV who do receive regular care get it paid for through public assistance programs. That's welcome relief for people like Bermudez because treatment regimens run anywhere from $2,000 to $5,000 a month. But to qualify for assistance, you have to earn below a certain amount annually and many say those thresholds are too low.
Murray Penner is with the National Alliance of State and Territorial AIDS Directors.
MURRAY PENNER: In many states, income eligibility is about $22,000. It's two times the federal poverty level and so, if you make more than that, you would no longer qualify for ADAP.
AGUIRRE: The cutoff leads many people like Bermudez to limit their incomes in order to maintain health care.
BERMUDEZ: One cosmetic company that I worked for - at the time, they were offering me full time hours and, because of the hours, I had to refuse it because I knew that would put me over the bracket to receive free medicine.
AGUIRRE: Problems qualifying for Medicaid aren't unique to people with HIV, but because AIDS drugs are so expensive, access to insurance is even more important. ADAP is meant to cover people who make too much money for Medicaid, but it's faced funding shortages and gaps since it was created in 1990.
ADAP needs to get funding re-approved by Congress every year, though the Obama administration recently released $79 million of additional money for the program.
Medicaid's expansion under the Affordable Care Act may also make it easier for people to pay for the medication they need and many hope that, with patents expiring on vital drugs in the coming years, cheaper generics may bring down the price.
Caring for people with HIV goes beyond treating the virus in the person. It's also critical to stopping the disease from spreading. David Holtgrave studies public health policy at Johns Hopkins University. He says people taking AIDS drugs are much less likely to transmit the virus to someone else.
DAVID HOLTGRAVE: When we can avert HIV infections, we're not only saving lives, we're also saving dollars, as well.
AGUIRRE: And, in the long term, that eases the burden on public assistance programs. As for Ruben Bermudez, who started taking medications four years ago, he's been committed to staying on treatment and, with his health intact, he hopes to eventually be able to buy private insurance and pay for his drugs himself.
For NPR News, I'm Jessica Camille Aguirre.
This is NPR News. Transcript provided by NPR, Copyright NPR.


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China's Huaxia Bank Co Ltd <600015.SS> may face some liability after a rogue employee sold unauthorized wealth management products which weekend reports claimed had stopped making payments, a bank official said on Tuesday.
An employee at Huaxia's Jiading branch, in a Shanghai suburb, sold the instruments issued by the Zhongding Wealth Investment Center without permission, and a police investigation is underway, the bank said on Monday.
Continue Reading Below
A spokesman for the bank's Shanghai operations told Reuters that police investigators may assign some liability to the bank.
"Currently, investors think Huaxia Bank must take the responsibility and no matter what we argue, they won't listen to us. So we must let the police and judiciary decide the different responsibilities of all parties involved in this case," Huaxia's Shanghai division spokesman told Reuters.
"But it cannot be understood that the bank will pay for the default."
Huaxia has said it was "aware" of reports that the investments could not be repaid when the product matured, but has not confirmed those reports.
So far, there has not been a high-profile case of default by a Chinese wealth management product, many of which are marketed by banks and highly sought by retail depositors for their higher interest rates. Banks' liability for the performance of third-party instruments is therefore untested.
"We will take the responsibility that we should take, but there are some legal procedures to follow," Huaxia Bank's Shanghai division head Zheng Chao told investors assembled at door of his offices, according to the Securities Times on Tuesday.
Bankers and analysts worry that the proliferation of wealth management products, which promise higher interest rates than savings accounts, poses a danger to the Chinese banking system because of their opacity, and the risk that banks may have to cover any default.
Many of the products essentially channel money to the so-called shadow banking system, where they help fund real estate and other projects at very high interest rates.
Chinese investment bank CICC warned in an analyst report on Tuesday of the long-term reputational damage to Huaxia if its depositors lose money, although it acknowledged the Zhongding products were sold without principal or interest guaranteed.
CICC estimated the amount sold through the Jiading branch at 20 million yuan ($3.21 million), citing Chinese media reports. Even if Huaxia had handled all the full 160 million yuan raised by Zhongding, that would equal only about 1 percent of the bank's annual pre-tax profit, CICC said.
"Huaxia should take responsibility for lack of internal controls," CICC wrote. "Short-term pain is better than long-term pain."
Huaxia has not commented on how many depositors bought the products, the amount of money involved, nor what its exposure might be.
Investors' suspicions were raised when one of the wealth management products issued by the Zhongding Wealth Investment Center failed to pay out as scheduled on November 26, the Securities Times said. It said all four products issued by Zhongding have failed to make payments.
Zhongding wanted to raise up to 200 million yuan to invest in a pawn broking operation and an Audi sales company among other projects in Henan, and promised investors annual interest of 11-13 percent, according to its prospectus.
The company that guaranteed the product told Reuters on Monday that it would not honor that guarantee, claiming the documents provided by Zhongding were incorrect.
Huaxia's Shanghai-listed shares traded down 0.2 percent early on Tuesday, compared with a 0.4 percent fall in the broader market . ($1 = 6.2279 Chinese yuan)
(Reporting By Aileen Wang and Lucy Hornby, additional reporting by Hui Li; Editing by Daniel Magnowski)


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A suicide bomber detonated his explosive vest Saturday at a wedding in the northern Samangan province killing at least 22 people including the bride's father, a prominent Afghan parliamentarian, officials said.
Ahmad Khan Samangani fought against the Soviet occupation in the 1980s and represented his province in the lower house of the Afghan Parliament. Officials said he was killed when the suicide bomber approached to greet him.
Samangani was celebrating his daughter's wedding in the city of Aibak, the provincial capital. He was welcoming the guests at the gate of the wedding hall around 8 a.m., said Lal Mohammad Ahmadzai, the spokesman for the northern police force.
Among those killed was the provincial chief of intelligence who was attending the reception, Ahmadzai said.
At least 42 people were also wounded in the attack.
No group immediately claimed responsibility for the blast. "Afghans don't search guests at a wedding reception," Ahmadzai said. "We had security measures taken but no one searched the suicide bomber."
Mansour Sawiz, the director of Samangan's provincial hospital, told McClatchy that 15 of the injured were in critical condition and his hospital referred them for better treatment to the local base where coalition forces are stationed and to Mazar-e-Sharif, capital of northern Balkh province.
Afghan President Hamid Karzai condemned the attack and assigned a delegation to probe the incident.
Samangani, the parliamentarian, was reelected in the disputed 2010 parliamentary elections. He was the father of ten children, four daughters and six sons. The daughter whose marriage was taking place was 18.
"She was wearing a green costume and the couple were just to do nekah," the Arabic word for marriage, said Aziza Musleh, a female senator in the Afghan national assembly who was present at Samangani's house.
"The family of Ahmad Khan is deeply grieved now. The happiness was replaced by the bloodshed."
The attack followed a Friday that killed the director of women's affairs in eastern Laghman province and her husband. At least 10 civilians also were injured in the explosion.
Meanwhile, the U.S.-led NATO coalition said in a statement on Saturday that one of its soldiers had died in an insurgent attack in eastern Afghanistan but didn't provide details.


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TL;DR - Dear Ada, do you add in AVR109 to your Atmega32U4 BB's yourselves or not?
I have been using an Atmega32u4 breakout board from Adafruit for firmware development. I can't quite sum up how pleased I am with its simplicity and flexibility. But now I come to a critical junction - I need to know whether the AVR109 bootloader that comes with the breakout board is standard issue from Atmel or whether Adafruit programs in this bootloader prior to shipping their product. The datasheet for the Atmega32U4 indicates a default USB bootloader is preprogrammed by Atmel and each 32U4 is shipped with this bootloader, but what is not clear is whether this bootloader they refer to in the datasheet is indeed the AVR109 bootloader. It comes from somewhere! I'd like to know where and how your bootloader gets onto your breakout board.
Thank you!
edit: I am assuming the AVR109 is indeed the standard issue bootloader, as the BB has no indication of the soldering rework necessary to reprogram the chip with a new bootloader. Just adding that so I don't look that stupid... :p


text: Garage Music GARAGE TANGO! By Cristina Baccin • Aug 6, 2012 Carny Mon. Aug 6, 7p: Donatello Brida, Italian leader of the portuguese tango orchestra TANO BRANCAMENTA Y LA MISERIA DE LUXE talks with us about what his "GARAGE-TANGO". Enjoy this conversation about his love for Argentinian tango, playing it with the accordion in Lisbon and Europe. He is the accordeon player of O´questrada, popular Portuguese band. (Interview in Italian with voice over in English). Host: Cristina Baccin


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Obama-style canvassing with France's Socialists
Latest update : 2012-04-28
FRANCE 24 joined a group of Socialist Party canvassers this week on the streets of Nimes in southern France, the only region where far-right candidate Marine Le Pen came out on top in the presidential election's first round.
Across France teams of Socialist activists are knocking on doors and talking to voters, in a door-to-door campaign inspired by US President Barack Obama's successful 2008 campaign.
FRANCE 24 joined a small team of Socialist Party (PS) canvassers working the suburbs of Nimes in southern France as the country gears up for the second round of the presidential election on May 6.
Locally, there is much at stake for the PS. Nimes is the main city in the Gard – the only administrative region in France where far-right candidate Marine Le Pen came top in the first round of the presidential vote.
French elections 2012
- New Sarkozy Scandal and the French Queen of Wimbledon
- '100 days...now what?'
- Record number of women and minorities in new French parliament
- Saved! Oh no, wait...
- Greens secure 'historic' gains in French parliamentary poll
- Socialists free to push through reform agenda
- Hollande to pursue ambitious European growth plan
- Le Pen's niece leads National Front's return to French parliament
- Far right's Le Pen beaten, but niece stages upset
- Royal concedes bitter defeat in La Rochelle
- Hollande's Socialists secure majority in French parliament
- Record abstention clouds French parliamentary poll
Incumbent President Nicolas Sarkozy will face off against PS candidate Francois Hollande in the second round, and although polls give Hollande a ten-point lead, much still depends on how Le Pen's supporters choose to vote.
The PS activists are leaving nothing to chance.
Beaming optimism and big smiles
Their approach and strategy is surprisingly American in a country where door-to-door canvassing is virtually unknown. For the first time in a presidential campaign, the socialist-party has organised a large-scale effort to draw in left-wing sympathisers who might have otherwise abstained, drawing inspiration from the Obama canvassing method.
Activists are furnished with lists of households in overwhelmingly left-voting neighbourhoods that have abstained from voting in previous elections (not the names) and these form the core of the highly coordinated strategy to target undecided voters.
Each canvasser has been given sales-type training and approaches the work with beaming optimism and big smiles.
They follow strict guidelines on how many minutes to spend talking with each person, how to focus on listening rather than lecturing, and to provide as much information as they can as efficiently as possible.
"People who don't agree with us get two minutes and those who do get five," said Laurent Thomas, a council gardener who organises all canvassing in Nimes and has been out on the streets every night for the past four weeks.
"We are always polite and we never argue with people. If they don't want to talk to us we simply move on.
"Our mission is to educate as many people as possible about Francois Hollande. We are not here to convert people. Above all we want people to go out and vote on May 6."
Le Pen's coy voters
Out on the streets, householders seemed surprised at the presence of these red-jacketed Hollande supporters.
Activist Kevin Boucard, 31, said the method "that we studied from the Obama campaign" was working, and that the team had been able to cover most of the city in the run-up to the vote.
- Record number of women and minorities in new French parliament
- Greens secure 'historic' gains in French parliamentary poll
- Socialists free to push through reform agenda
- Hollande to pursue ambitious European growth plan
- Le Pen's niece leads National Front's return to French parliament
- Far right's Le Pen beaten, but niece stages upset
- Royal concedes bitter defeat in La Rochelle
- Hollande's Socialists secure majority in French parliament
- Record abstention clouds French parliamentary poll
- France's parliamentary runoff as it happened
- French Socialists aim for majority in election runoff
- Polls predict election doom for conservative UMP party
- 'Mortified' Royal hits back over First Lady's tweet
- Key politicians face defeat as Socialists eye victory
- French press pounces on first lady's Twitter mishap
"People aren't used to this direct approach in France," he said. "Many of our new activists are a little scared to approach people directly, but they soon get over their shyness."
In a region that saw 25% of voters cast their ballot for Marine Le Pen's National Front in the April 22 first round of the election, her supporters are surprisingly coy.
Peering round her front gate, one mother of two children leaning out of the house windows told FRANCE 24: "I voted for Le Pen in the first round. I'm abstaining in the second. I won't vote for either Hollande or Sarkozy."
She refused to be named or be photographed.
Canvassing finishes at 8.30pm sharp because "people are having dinner and we mustn't disturb them" and the team gets together for to debrief on the evening's work.
"It's an important part of the day's work, we learn from each other and it makes us feel good about what we've done," says Thomas.
They disperse after copious kisses on cheeks – they do it three times in the south. No high-fives in Nimes.
Laurent Thomas (right) organises all door-to-door canvassing in Nimes. He is joined by his father Claude (left) who has been a PS supporter since 1974.
Canvassers work their patch in pairs. Friends Laurence Choimet (left) and Leila Bekkaoui (right) feel they work best together.
This is social worker Kevin Boucard's first election as a PS activist. "Hollande may be ahead in the polls, but the game is not done by any stretch," he said. "Nicolas Sarkozy is extremely combative and I think the result will be much closer than anyone thinks."
Mohammed Snabi looks after disadvantaged youngsters. Canvassing is "all about convincing people to vote and not to be indifferent - too many people feel that the elections do not concern them and will change nothing."
Kheira Ghezali, of French Algerian origin, said that "most people who voted for [far-right leader] Marine Le Pen aren't racists, they're simply fed up with Sarkozy."
A resident in this affluent suburb seems surprised to see the red-coated activists. She will vote for Hollande, she says.
Leila Bekkaoui talks with a Hollande sympathiser who wasn't planning on voting because he thought the result was a foregone conclusion.
This resident refuses to say how she will vote, but seems to enjoy the attention.
Not everyone is at home, although canvassing takes place between 7.30 pm and 8.30 pm on weekdays to maximise the chance of direct contact.
Time to move on after a discussion with this couple exceeds the allotted five minutes.
At every door where there is no response, the canvassers leave their calling card with one simple message: "Vote."
Date created : 2012-04-28


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As AMC's Western "Hell on Wheels" rides back onto TV Sunday, star Anson Mount's character, Cullen Bohannon, is a shadow of the man so driven to avenge the murders of his wife and son.
Reeling after he killed the wrong man at the end of Season 1, the former Confederate soldier has hooked up with bandits who repeatedly rob the trains of his former employer, Thomas "Doc" Durant (Colm Meaney). He doesn't care if he lives or dies, Mount told reporters Wednesday during a conference call.
"I think he's to the point of just absolutely devil may care—absolutely," he said. Speaking as Cullen he added, "'If the Lord decides to take me now, or the devil, that's just fine with me.'
"He's absolutely gotten to that point, to the extent that I think at the beginning of the second season he's actually quite delusional."
It's a gloomy opening to a new season, but then "Hell on Wheels" went to some dark places in its freshman season last fall. The series follows the traveling town, called Hell on Wheels, that springs up to house the people building the westward-moving Transcontinental Railroad in the late 1860s, including Elam Ferguson (Common), a former slave who bonds with Bohannon despite their backgrounds.
The show became a hit in its first season, averaging 3 million viewers per episode, second only to "The Walking Dead" on AMC—and ahead of "Mad Men" and "Breaking Bad" in the Nielsen ratings. Critics weren't as pleased with the series from Joe and Tony Gayton, with many saying it focused too heavily on plot over character.
Mount said this season the show is more character-driven. "And strangely enough, it's led us into more interesting action because of that, because now the action is tied into character growth and character reversal," he said.
In that respect, audiences this season will see there's more to Cullen than his obsession with revenge. Mount said the season explores why he left home to fight in the Civil War, and why he continues to fight.
"The inner monster that ... took him away from his family during the Civil War rears its head in a different way," he said. "And the whole season I think is about defining what that thing inside of him is."
Mount talked more about the new season, Cullen's journey and his relationships with the other people in Hell on Wheels.
I was wondering if you could talk about where Cullen's head is at as we begin the season and going forward a bit.
He's faced with a life and death option. It's very clearly laid out on the table. He chooses life for obvious reasons. But then he ends up back in Hell on Wheels and then the ongoing question is why isn't he running? And that's a question for him as well throughout the entire season. That's a good question. And the answer to that is not what we're going to be led initially to believe, I don't think.
It's going to turn out to be for reasons that are deeply personal and have to do with the deeper motivations of the character, just like you find out starting in the second season of "Breaking Bad," it's a show about ego. You can't do a show about cooking crystal meth for six seasons. It just doesn't work. So it becomes a show about ego and everyone has their ego and they bump up against each other in different ways.
In the same way, this show is about ambition and that's what's going to be the driving force of the drama going forward.
Cullen and Elam's relationship is fascinating to me and it seems like there's a mutual respect and admiration. Can you tell me how approach that?
You know what? I agree with you. I think it's becoming the most interesting relationship in the series. Common and myself and the writers were very definite that we were not going to allow this to become Richard Pryor and Gene Wilder—you know, the black guy and the white guy are going to be buddies and everybody's going to love each other.
We wanted to be very true to the tropes and the stereotypes and the conflicts at that time, particularly between a former slave and a former confederate. And yet let them find themselves in situations where they have to meet each other on equal footing and situations where they end up needing something from the other person that's purely practical and yet forces them to really listen to the other person.
And I think we did a really good job with that in the first season and I think we've done an even better job of it in the second season because you end up with the two men in sort of the same position.
They're both in different ways in charge of security in Hell on Wheels and you have a man who's led men before and a man who hasn't. And that doesn't matter what color skin you are at a certain point. One has experience and the other one doesn't.
So will they be boxing each other this season?
[Laughs.] We're still shooting second season so maybe. There're some fights here and there, but I don't think between Elam and I yet.
The Swede (Christopher Heyerdahl) had it in for Cullen in the first season and now that he's in the lower position he's in, will these two still butt heads?
Oh yes, man, the Swede is going to be really interesting. Look, he's starting at a very low place, but of all the characters in the show, I would say the Swede is the most emotionally intelligent and, therefore, dangerous character. And he's going to some really interesting places this season that you're probably not even getting a glimmer of yet in the first two episodes.
Cullen was deeply affected by killing the wrong person at the end of Season 1, but was he ever all that happy or satisfied after killing any of the men who were responsible for the deaths of his family members?
That's a great question, man. I'm glad you asked that. I decided pretty much before ever finding out that Harper was going to turn out to be the wrong man, that at the end of the season, when and if Cullen does get to put his hands around the throat of someone, when he completes the deed, it's not going to be the release or the relief that he thought it was going to be. It's a deeper hollowing out of himself, that he finds there is actually nothing there.
And you've probably already seen in the second episode when Doc comes to see him before [he is to be executed] and Cullen makes the confession. He says, "You must feel awful about that," and [Cullen] says, "That's the thing. I don't feel nothing about it. Not a damn thing." And that's the real tragedy, I think, of Cullen in the first season.


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By Noel Randewich
SAN FRANCISCO (Reuters) - Applied Materials, the top manufacturer of equipment for chip makers, on Wednesday named a new executive to head up two poorly performing non-core businesses - solar and display - though it said the business groups are not themselves being combined.
Applied Materials said it hired KLA-Tencor veteran Ali Salehpour to head the two groups.
Chipmakers worried about the global economy and wrestling with declining PC sales have been spending less on new manufacturing equipment sold by Applied Materials.
Applied Materials' non-core businesses have also performed poorly, and the company said in October it would cut its work force by 6 percent to 9 percent to reduce costs.
The solar panel industry has more than enough capacity to meet demand, and manufacturers of displays for TVs and other devices also face supply gluts.
Although Salehpour will head the two business groups, they will remain separate, said Applied Materials spokesman Matt Ceniceros.
Shares of Applied Materials slipped 2.26 percent in after- hours trade, after closing 2.3 percent higher at $10.60 on Nasdaq.
(Reporting By Noel Randewich; Editing by Bernard Orr and Leslie Adler)


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Becca Jewel Dust (Erzulie, Luella, Erlina)
The Jewel of Your Eye with Becca
Becca Jewel Dust ($24.00 for 0.04 oz.) are loose multi-purpose powders made without talc or fillers. There are sixteen shades in the full range, from shimmering champagnes to baby blues. I picked up three shades when Becca was on HauteLook a few weeks back.
- Erzulie is a soft lavender with a gray cast and lighter lilac and blue shimmer.
- Luella is a gold shimmered green-toned turquoise with a deeper turquoise base.
- Erlina is a lightened, spring green with a strong yellow undertone with a near metallic, slightly frosty finish.
One thing I really enjoyed about these was that they work nearly as well dry as they do wet. When they are used wet, they do create a smoother, more solid color, but used dry, they hold together pretty well. They worked well over eyeshadow primers as well as cream eyeshadows.
All three shades I tried out are actually colors that I don't quite have in loose form, and the way they shimmer is very reflective and sophisticated, actually–particularly when used on eyes. I could see some of the lighter, more neutral shades being used as an all-over dusting on lids for a little oomph without doing much else.
The packaging is stylish and easy to store–small, mostly square, and just elegant. I really wish you received more for the price, though — 0.04 oz. is so underwhelming for a product that costs $24 — and it's a little less and a little more in cost than other loose shadows by high-end brands. I'm sure most of us will not get through a single container all that quickly, though, and like most loose colors, a little goes a long way.
If you want to know more about how products are evaluated, read out Rating System FAQ! 🙂
- Product: 28/30
- Value: 6/10
- Ease of Use: 4/5
- Packaging: 4/5
Recommendation: I wish you got a little more product in each container, but the colors I tried were beautiful and shades I haven't seen too often. The quality was lovely with smooth, rich color and beautiful shimmering finishes.
Availability: Becca


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Now this in my kind of hippity-hop. On Tuesday's "The Tonight Show," Jimmy Fallon and Anne Hathaway performed Broadway versions of famous rap songs.
They gave a show-tune makeover to Snoop Dogg's "Gin and Juice," 50 Cent's "In Da Club" and Kendrick Lamar's "Bitch Don't Kill My Vibe."
At the end of that last song, Hathaway offered a special message to all those "dirty, Hatha-hating, bitch-ass" folks.
Want more? Discuss this article and others on Show Patrol's Facebook page.


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A few months ago I purchased yardage of some Civil War commemorative fabric. Next year is the 150th anniversary of the war. There will be celebrations and festivities, programs and also a time for remembering. I have both Union and Confederate ancestors so my allegiance is split.
This weekend I decided it was time to do something special with the fabric. Using three different fabrics, plus the muslin for the lining, I started cutting fabric, batting and interfacing in anticipation of making a tote bag. Very seldom do I sew with a pattern, so this was just measure, cut with the rotary cutter and sew. My mother used to tell me that sewing is not done right if you don't have to rip. I ripped four times on my tote bag. Part of that was because I was thinking of Cherokee ancestry while I was sewing and just not paying attention. Somehow those Cherokees kept getting in the way!
On the front of the tote bag is a fabric photograph I made of my late husband's first cousin, three times removed, Richard Edmond Weathers (1836-1870). He was the son of Squire Beauchamp Weathers and Ruth Sharpe. Richard served in the Union Army, enlisting as a Quartermaster Sergeant on 13 August 1863 in Lamb's Independent Cavalry Regiment in Indiana. Less than a year later he was promoted to Captain in Co. H, 131st Regiment, 13th Cavalry, Indiana Volunteers. He was married to Elizabeth Shaw in 1859 and had two children when he enlisted. The 131st Regiment, 13th Cavalry was the last regiment from the state to be mustered out of the U.S. Army on 10 November 1865. The five oldest sons of Squire and Ruth Weathers served in the Union Army in the Civil War and fortunately all five came back to Indiana alive.
The background fabric behind the photograph is of a cannon and tiny labels saying "Remember Me." No genealogist will ever forget a Civil War ancestor or relative.


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The Best Quotes From ASAP Rocky and Alexander Wang's 'Interview' Mag Story
Uptown's favorite pretty boy has claimed yet another magazine cover. A$AP Rocky graces the front of Interview's April issue, flashing a mouth full of precious metals. The fashion fanatic, interviewed by fashion great Alexander Wang himself, dishes on mastering style and swag while still having substance.
Flip through for the accompanying flicks as well as the best quotes.


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Kissimmee, Florida
Even anglers who consider themselves saltwater-exclusive should take a ride to the fresh side on central Florida's Kissimmee Chain of Lakes. This network of 20 public lakes ranging from 200 to 44,000 acres and interconnected by rivers and canals provide some of the best fishing on the planet for largemouth bass, bluegill, shellcracker and black crappie. The largest of the chain is 44,000-acre Lake Kissimmee, where in February a Tennessee angler caught, weighed and released a 14-pound, two-ounce 'hawg' using a spinnerbait. Nearby Lake Tohopekaliga, known as Lake Toho or "West Lake," is where Dean Rojas, a professional angler from Arizona, made BASS tournament history in 2001 with a one-day total of five largemouth weighing 45 pounds, two ounces. A good central launching point is downtown Kissimmee's Lakefront Park on 18,000-acre Lake Toho, which has a large boat ramp and shore fishing. Bass anglers favor live shiners and artificial lures such as light-colored spinnerbaits; Texas- or Carolina-rigged plastic worms in colors of watermelon, black grape and junebug on bait-casting gear. Hot spots include Makinson and Little Grassy islands, Goblets Cove, North Steer Beach and Lanier Point. The Kissimmee Chain is close to a private fishery like none other in Florida and perhaps the country. Barramundi, a snook-like fish native to Australia, is being cultivated for food and catch-and-release in a small network of freshwater ponds on a private ranch in the small town of Holopaw. Visit osceolaoutback.com for fees and availability. This outstanding freshwater fishery is close to Disney World and features much cheaper lodging than can be found at the Mouse. Go to VisitKissimmee.com for lodging, fishing and other information.
Copyright © 2018, Orlando Sentinel


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#FollowJourn: @jamescridland / radio futurologist
August 24th, 2009Posted by Judith Townend in Broadcasting, Recommended journalists, Social media and blogging
#FollowJourn: James Cridland
Who? 'Radio futurologist' and director of MediaUK.com.
What? Currently working for BBC Future Media & Technology's Audio & Music team but will leave in early September. Full biog here.
Where? @jamescridland / james.cridland.net / mediauk.com / radioacademy.org
Contact? Via his blog.
Tags: BBC, director of MediaUK.com, James Cridland, mediauk.com, radio


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Skip to comments.Spencer: Corbett makes right call challenging NCAA
Posted on 01/05/2013 9:19:35 AM PST by FlJoePa
By GIL SPENCER firstname.lastname@example.com
So finally someone in a position of authority in this state is standing up to the late-hitters and pile jumpers that used the Penn State scandal for their own shameful and hypocritical purposes.
That someone is Gov. Tom Corbett, who has finally filed a lawsuit against the National Collegiate Athletic Association and its publicity-whore President Mark Emmert.
Better late than never.
Last summer, Emmert declared PSU in violation of the NCAAs regulations without citing a single concrete NCAA rule that the school had broken and imposed crippling sanctions on its storied football program including a $60 million fine.
Back then, Corbett suggested the school accept these draconian punishments and move on. Well, he has changed his mind. Good!
Whether the governor has done this because he thinks it will help him in his bid for re-election next year or because he truly believes a real injustice has been done and needs to be righted, is, to my mind, completely irrelevant.
I have a suggestion for those cynics who want to dismiss Corbetts action as nothing more than a political stunt and here it is: Read the complaint.
It isnt long, just 43 pages, doubled-spaced. But it is far more convincing in its assessment of the motivations of Emmert and the NCAA, than the Freeh Report ever thought of being concerning its sad targets.
One of the complaints authors is Melissa Maxman, an expert in antitrust law for the Washington firm of Cozen OConnor. Daily Times readers will remember her from her 2001 run for the state Senate as a Democrat from Swarthmore.
When I called her about the suit, she said she couldnt talk about it and referred me to the governors office. But the lawsuit speaks eloquently enough for itself. It lays out the case against the lazy and arrogant NCAA, clearly and damningly.
The NCAA has announced itself disappointed in Corbett for challenging its authority to arbitrarily and capriciously harm a member institution. Youd be disappointed too to have your shortcomings pointed out so accurately to the public at large.
Remember how the alleged cover-up of Jerry Sanduskys crimes was supposed to have been motivated by PSU officials fear of bad publicity? Well, thats something the NCAA well understands.
For years, the NCAA has been mocked in the press for its multiple failures to enforce its own actual rules and regulations.
So when this unprecedented case presented itself, it also provided the NCAA a chance to finally enhance its own public image.
As the lawsuit states, with Penn State still reeling from the scandal last July, the NCAA was not about to miss an opportunity to bring Penn State down even further, or to attempt to improve its own public image by asserting its relevance as a protector of student-athletes.
Never mind that the school hadnt violated a single, specific NCAA rule. And never mind that, in the past, the NCAA had steered clear of criminal matters far outside of its purview.
When in 2003 a Baylor University basketball player murdered another player and the coach was caught on tape arranging a cover-up, the NCAA imposed no penalties relating to the murder and cover-up.
In 2010, when a University of Virginia mens lacrosse player murdered his lacrosse-playing former girlfriend, the NCAA found no reason to sanction the school. And this, despite the victims mothers allegation that the university repeatedly ignored signs of the killers violent, erratic and threatening behavior.
According to the U.S. Justice Department, the University of Montana recently failed to investigate numerous allegations of rape by Montana football players. Sanctions from the NCAA? None.
All these cases show that the NCAA has held Penn State to a very different standard than other member schools.
Remember, its not as if the guilty parties in the case werent being punished. Sandusky was prosecuted and jailed. Others were charged with crimes and fired. Justice was being done without the help of the NCAA.
But the Sandusky scandal proved too tempting for the likes of Emmert and his fellow due-process-be-damned moralizers.
Ignoring their own protocols and procedures (well documented in the complaint) the NCAA put a gun to the head of Penn States accidental president, Rodney Erickson. Either he agree to their demands or the school could face the dreaded death penalty. Erickson agreed to all the penalties that the NCAA decided to inflict.
So what if thousands of completely innocent people were hurt in the process from waitresses and bartenders in Happy Valley, to students, athletes to just plain Nittany Lions fans and taxpayers? The hell with due process. And a bunch of outraged, drooling know-nothings were fooled into believing this is what justice is supposed to look like.
Even Emmert admitted last year that the sexual abuse of children on a university campus by a former university official and even the active concealment of that abuse, while despicable, ordinarily would not be actionable by the NCAA.
But this was different, according to Emmert. The culture of worshipping football at Penn State had to be changed, he said. That was his justification for his taking all these unprecedented powers and actions. This from the head of a $1 billion-a-year organization that makes its millions helping to create the very sort of sports-crazy culture it now claims is evil and must be destroyed. At least in Happy Valley.
Last July, right after Emmert held his now-famous press conference and admitted the lack of institutional precedents for his actions, one prescient wretch wrote:
In ignoring just about every one of its own procedures for handling disciplinary actions, Emmert has opened the NCAA up to a civil action from Pennsylvania taxpayers, some of whom dont like the idea of a publicly owned university ceding control of its future to a privately run association with an agenda geared to money-making and heavily greased with sanctimony.
Well, thank you Gov. Corbett, whatever your motives, for stepping up on behalf of not only Pennsylvania taxpayers, but for the students, athletes, football fans and the small business owners in Happy Valley that financially depend on the competitiveness of the Nittany Lions.
The NCAA now stands formally accused of violating Section 1 of the Sherman (Antitrust) Act.
Oh, and that prescient wretch? Well, youre looking at him.
But what I wrote then is nothing compared to the ugly truth exposed in this needed and poignant complaint.
Read it, Dr. Emmert. And weep.
Read it, the rest of you, and learn something.
My problem with the lawsuits concerns the cost. Presumably, Pennsylvania, like most states, is cash strapped. For example, we have crumbling roads and bridges, and public transportation systems are broke. I would rather see the money spent on transit matters than this lawsuit.
I thought it was pretty remarkable that after everything that happened to Penn State to include loss of some of their star players, scholarships and sanctions that they did as well as they did in 2012.I have never been a Penn State fan, but I think that the coaching staff deserves a lot of praise for the job they did. Well done Nittany Lions!
The lawsuit has merit but I think Corbett himself made the move to save face with PSU voters in time for reelection. He flip-flopped on the sanctions and faces a GOP challenger in Bruce Castor.
Nothing will ever go to court. If it does it will be the trial of the century as far as sports goes. The entire existence of the ncaa could be on the line.
Sure the state has spent money to prepare this suit - as has Corman and his suit, but if Judge Kane gives them standing, the ncaa is going to look for a way out. They can't even go into discovery with what they have - a deeply flawed freeh report and a direct 180 on their own rules and bylaws.
The suits left to come that I'm aware of are the Lettermen - looking for their wins restored, and the Paterno family - looking for the wins restored and massive, massive likeness damages.
Total Revenue 106,614,724
Total Expense 88,041,921
BO'B did a great job coaching and did a great job shaking down the cowards in Old Main the other day.
PSU has a top 25 recruiting class coming in and it includes the #1 drop back passer and the #1 tight end.
If it was all about football for these kids (Hackenberg and Brenneman), they wouldn't choose PSU.
The most appalling thing to me about the sanctions was the multi-multi-million dollar fine that Penn State had to pay to the NCAA!! Supposedly it was "for the children", but how much do want to bet that no more than 5% will ever be used for outreach, and the NCAA profits as they use the rest for "administrative purposes". The NCAA is so full of it.
Exactly. It's a $60 million slush fund. I would rather have seen the money earmarked for the investigation of Second Mile Foundation and the network of pedophiles it was involved with.
I believe there are dozens of high-level, prominent politicians and influential people involved in this. Except for internet blogs and an occasional article here and there, it's the story that will never see the light of day. IMHO, the state prosecutor who disappeared without trace a few years back paid with his life for having the names and the goods on these people.
google Greg Bucceroni sometime. I don't find him particularly credible. Yet.
I think the fellow poster was referring to the costs of filing and pursuing the suit to the state of Pennsylvania.
Penn State University has nothing to do with the filing of this lawsuit - in fact the milquetoast morons in charge have practically disavowed it.
Someone could make the case that the NCAA ruling will cost Pennsylvania more in the long run. Don't ask me for numbers!
Joe Paterno to the students who had assembled outside his home:
"I wish I had done more."
John - the exact quote was: "In hindsight, I wish I had done more". And it wasn't to the students, it was to the local media.
The key word is "hindsight". It is no more an admission of any sort of guilt than me wishing I had done something about 9-11.
Read Posnanski's book and it talks a lot about this quote and what the media (espn) did with it. Watch Ziegler's film and you'll see how a genuine act of sorrow and remorse (not guilt) is spun into some sort of confession.
Ridiculous. Especially when it comes from the mouth of an 84 year old man dying of lung cancer.
Pedo State should have been bulldozed to the ground and then nuked from orbit just to be sure.
The author actually describes you in his column (which you didn't read). Here's where you come in:
"The hell with due process. And a bunch of outraged, drooling know-nothings were fooled into believing this is what justice is supposed to look like."
Good move on the lawsuit....with Penn State being a "state funded school"...the PA govt has every bit of standing in this case. And, if the NCAA forced this agreement on PSU with intent to commit fraud or deceive....the courts will void the settlement
The NCAA should have kept out of the Sandusky matter.
They will lose the lawsuit brought by the Paterno family, as SCOTUS has already ruled in the 1991 case Tarkanian v NCAA that the NCAA must give "due process" to coaches when considering punishment (there was no hearing before the NCAA stripped JoePa's wins). I could be the lawyer for the Paterno family and win the case...that is how certain I am the NCAA loses that
The NCAA has a little more leeway with the member schools...but still...that Freeh Report and Agreement cannot withstand scrutiny under discovery and deposition. PSU should not settle with the NCAA without a massive reduction in the probation and other punishment.
What morons are doing the legal work and risk management for the NCAA?
And, I know the Sports Media (which is in bed with the NCAA) is not going to give proper analysis of any action favorable to Penn State. Sports Media is too busy cheering on their alma mater (Syracuse) and celebrating Jim Boeheim record setting win mark....but will never mention how Boeheim covered up child molesting by his long time buddy Bernie Fine...during SU basketball road trips
Thanks SeminoleCounty. Judge Kane (Harrisburg) could hold the future of the ncaa in her hands - that's how far they overstepped their bounds in this case.
As for the Paterno suit, if I was Mary Kay Paterno - who holds the licensing rights to her Father, I would sue the ncaa for $100 million. Then I would sue louis freeh and whats left of his tattered business for another $100 million.
Wick Sollers is no schlep. He's been waiting for the right time to pounce on the ncaa and that time is near. In addition the Lettermen will be filing as well. There is also rumor of a Centre County lawsuit - to be filed by local business owners.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


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- Briefing Paper - 2/1/07
Research Informing Message Strategy of Chronic Disease Prevention and Control Consumer Education Campaign.
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Literature Review
Brian Hensel, PhD, University of Missouri-Columbia, completed a comprehensive review of existing literature to inform development of a general thematic message and supporting sub messages for the media campaign, educational materials, and grassroots partners. Grounded in empirically based health communication theory, this research examined knowledge, beliefs, and social norms in the target market or general population related to the targeted health and health care behaviors. It also examined individual-level perceived self-efficacy or confidence in achieving these behaviors, recognizing the additional disproportionate structural barriers such as lack of health insurance that many members of the target market face. Additionally, several research-supported message strategies are recommended along with media and grassroots message channels utilized by the target market. The executive summary and full report can be found above.
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Joe Walsh needed to be just about perfect as the Blue Eagles could only muster four singles, and he was. He retired 17 Marshfield batters in a row and didn't give up a hit..
PLYMOUTH - What a difference a year makes.
By his own admission, Joe Walsh was rocked in his only start on the mound last season when he took a loss to New Bedford. Monday night, the Plymouth North sophomore was the one rocking and rolling as he needed just 80 pitches to spin an absolute gem of a no-hitter over Marshfield in the first night baseball game played on the new Henry Cryer Field.
He needed to be just about perfect as the Blue Eagles (2-0) could only muster four singles off Rams starter Greg Langner in the 1-0 win.
Walsh walked Nick DeGrenier in the first inning and then again to start the seventh, but in-between he was absolutely perfect, working flawlessly with Mike Hickey and Cullin Cosgrove behind the plate to retire 17 Marshfield batters in a row.
"Mike and Cullin did a great job with me," Walsh said. "I was a little too hyped at the start of the game and Mike calmed me right down when I needed it. From there I just tried to pound the zone with strikes and stay focused. I had the fastball working pretty well tonight, with a slider and a change thrown in when I needed them."
In every no-hitter there is always at least one play that keeps the dream going. That play came in the bottom of the second with two out when Pat Fey streaked in from center field for a diving catch on Jacob Maher's sinking line drive.
"What a great catch," Plymouth North Head Coach Dwayne Follette agreed. "It's always the little things that decide a game like this one. We've got to hit the ball better, but our pitching has been right on target so far."
Plymouth North did put some runners on base against Langner, but three double-plays over the first five innings shut the door on any rallies. They finally got something on the board in the top of the seventh. With two out and Colby Randall standing on second base, Ken Drew poked a clutch single to right field. Randall was off at the crack of the bat and beat the relay throw to the plate by the smallest of margins to score the only run of the game.
With Marshfield the home team of record for this game, they had a chance to answer back in the bottom of the frame. DeGrenier walked on four pitches, but Nick Pomella grounded out and John White hit one right back to Walsh for a 1-6-3 twin killing to end the game.
Email the reporter at firstname.lastname@example.com and follow him on Twitter, @davidwolcott1.


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DuPage County officials have identified the skeletal remains of a man found last month by two children in Woodridge.
Dental records identified the man as 37-year-old Anthony Scott Arcaro of Lisle. He'd been missing since 2007.
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NICOSIA, Cyprus (AP) — Cyprus' president said Wednesday he would refuse any request by international lenders to sell off state-owned companies as part of a finalized agreement to bail out the crisis-hit country.
A draft of the bailout deal by the rescue creditors — the European Commission, the European Central Bank and the International Monetary Fund — says Cyprus will have to consider privatizations if it's debt is deemed unsustainable.
But Dimitris Christofias said he won't consent to privatizations because he's "bound" by his party AKEL, which has communist roots, and by the government. Christofias suggested that should the bailout creditors insist on including privatizations in a deal, the accord would have to wait for the next government to sign it. Cyprus holds presidential elections on Feb. 17 and Christofias is not seeking reelection.
"I hope that when discussions conclude they won't ask us to privatize state-owned organizations because if they do, and I want to make this perfectly clear, I have no intention to proceed as president of the republic with such a move," he said.
Cypriot banks, which took huge losses on bad Greek debt and loans, are estimated to need up to €10 billion ($13.19 billion) in rescue money. That's more than half the value of the national economy and too much for the government to handle on its own.
It would also make the rescue one of the largest bank bailouts ever as a proportion of gross domestic product, second only to the 1997 Indonesian bailout, according to estimates by Cyprus' Central Bank.
If the Cypriot government were to spend the full €10 billion for the banks, plus €1.5 billion to cover government deficits over the bailout's four-year duration, public debt would rise as high as 140 percent of GDP.
Cypriot authorities contend that the banks' needs are notably less than €10 billion. An exact figure on the banks' needs is expected sometime in the middle of this month, when international investment firm PIMCO and auditors Deloitte finish looking through the lenders' books.
Cyprus' eurozone partners will decide on the country's bailout deal on Jan. 21.
The government says it has enough money to pay its bills until March, when it hopes to receive the first installment of bailout money once an accord is signed. A new government takes over March 1.
Cyprus' economy — the third smallest in the eurozone — is projected to shrink this year by 3.5 percent while the jobless rate is forecast to reach 13.7 percent.


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