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Activate Your Longevity Genes: Five Natural Compounds Simulate Caloric RestrictionFebruary 2010
By Julius Goepp, MD
The most scientifically validated way to extend life span—from single-celled organisms to mammals—is caloric restriction.1 This technique has been shown to boost life span by nearly 100% in some species.2
Reducing the number of ingested calories—while maintaining healthy intake of essential nutrients—triggers a cascade of anti-aging mechanisms in the body. More than 70 years of research have established its life-extending power.3
Modern science has only recently begun to unravel the mystery behind how calorie restriction so radically extends life span. At its core lies favorable alterations in gene expression—one of the body's adaptive responses to reduced calorie intake. By activating certain genes and disabling others, caloric restriction dramatically slows aging.
This retardation of aging delays the onset of degenerative disease while improving biomarkers of youth, ranging from metabolic rate and insulin sensitivity to cardiac health and cognitive function.4
By the same token, the consequences of caloric overconsumption are equally profound. Every excess calorie brings you one step closer to age-related illness and death.
This is true at any stage of life, whether you're lean or overweight, regardless of your health or nutritional status.5-7
Eating more than your body needs (excessive energy intake) can load the blood with triglycerides, glucose, homocysteine, and pro-inflammatory chemicals. The results are accelerated aging processes, prompting deterioration across multiple biomarkers of health.8
Most humans find it difficult to submit to a sufficiently rigorous dietary regimen, leaving the benefits of calorie restriction tantalizingly out of reach. Until now!
In this article you will discover the most compelling evidence to date on the effects of caloric restriction. In a milestone 20-year study of Rhesus monkeys—our close genetic relatives—a modestly restricted diet resulted in a three-fold reduction in the risk of age-related disease!9
You will also learn about five natural compounds that favorably modulate gene expression to support a more youthful health profile. These "caloric restriction mimics" simulate many of the beneficial effects of caloric restriction through multiple pathways.
Aging individuals may now enjoy some of the youth-promoting, disease-fighting mechanisms of caloric restriction—without strict dietary measures.
A Milestone in Longevity Research
In 1989, a group of anti-aging researchers launched what would prove to be the most comprehensive study of caloric restriction (CR) to date.10 Rhesus monkeys were chosen as subjects because they exhibit biological and aging characteristics strikingly similar to humans. The results, published in 2009 in the prestigious journal Science,9 provide compelling evidence of CR's age-delaying, disease-fighting power.
The monkeys were split into two groups. Half were allowed to eat naturally, without restraint; the other half subsisted on a nutrient-replete diet 30% lower in total calories than they would normally consume. After 20 years, 37% of controls had died of age-related causes, as opposed to just 13% in the calorie-restricted group. In other words, caloric restriction cut degenerative disease risk by a factor of three.9
This study's findings are even more tantalizing when one sees that it did not require severe lowering of calorie intake to produce these striking results. Americans typically consume 100% more calories than they need. It only required a calorie reduction of 30% to achieve the remarkable benefits in this study.
The Rhesus monkey study also conclusively demonstrated caloric restriction's protective power. Over the course of 20 years, virtually all measured biomarkers of health were superior in the CR group.9
These findings have profound implications for humans. Rhesus monkeys are as vulnerable to chronic, age-related disease as we are. They lose their strength over time. Many become obese, fall prey to metabolic syndrome, and succumb to diabetes. They develop cardiovascular disease and cancer. And like aging humans, their brains shrink as they get older.
Yet among the calorie-restricted group, incidence of cardiovascular disease was half the rate ofcontrols. Not one member exhibited any symptoms of impaired glucose control or diabetes, whereas 40% of monkeys who ate as much as they wanted had become diabetic or pre-diabetic.9
Calorie-restricted monkeys lost fat weight, but did not sustain loss of muscle mass observed in the control group. CR also inhibited reduction in brain volume, especially in areas governing cognitive and motor function.9
The robust health of the CR group compared to controls is clearly evident in photographs of the monkeys from the control and CR groups.9 (See figure 1 below.)
Benefits of Calorie Restriction in Humans
All available data indicate that calorie restriction also slows aging and reduces the risk of killer diseases in humans as well. Individuals who impose a 20% reduction in their calorie consumption for 2-6 years lose fat weight and show significant improvement in their markers of aging, including blood pressure, cholesterol levels, and glucose control.11
Even brief periods of caloric restriction can temporarily improve core body temperature and insulin sensitivity, which happen to be markers of longevity.11,12 In clinical studies, short intervals of caloric restriction have reduced systemic inflammation—an underlying factor of so many chronic, degenerative diseases.
More youthful heart muscle performance13 has also been observed—caloric restriction appears to increase the number of vital energy-producing mitochondria in heart and skeletal muscle, reducing the oxidative damage that accelerates aging.14-16
No other intervention documented in the scientific literature can compete with caloric restriction as a candidate for slowing aging and supporting youthful health in humans.
It is regrettable that most aging individuals don't lower calorie intake by the 20-30% reduction required to reap the benefits of caloric restriction, as it can dramatically lower disease risk and add years to their lives.
Caloric Restriction "Mimics" and Gene Expression
The problem many people have in sufficiently reducing their calorie intake has led to a novel scientific solution.
Researchers have identified a select group of nutrients that trigger many of the same underlying mechanisms of action as caloric restriction. Among the most promising of these caloric restriction mimics and enhancers are resveratrol, pterostilbene, quercetin, and grape seed extract, along with black tea extract. These nutraceuticals have been shown to generate many of the same effects in the body as caloric restriction, without significant dietary modification. In particular, they "mimic" caloric restriction's favorable impact on genes that influence the aging process.
Genes have the capacity to directly affect life span by regulating a broad spectrum of aging factors, from inflammation and metabolic function to immune response. Calorie restriction exerts a beneficial effect on the activity of gene expression, supporting healthy cellular function through numerous physiological pathways. This includes:
Compounds that mimic caloric restriction bring about favorable changes in gene expression and improve the primary biomarkers of aging.
Controlling Nuclear Factor-Kappa B
Calorie restriction sharply limits expression of nuclear factor-kappa B (NF-kB). In the cells, NF-kB is a critical gene regulator that governs response to pro-inflammatory cytokines, free radicals, cholesterol levels, immune function, and cancer prevention.17-24
The nutrients that mimic caloric restriction also act to stabilize NF-kB regulation and help combat the age-related conditions associated with unfavorable NF-kB activity.
Resveratrol activates sirtuins,25 a powerful family of "information regulator" proteins that inhibit NF-kB, reducing inflammation throughout the body, such as that caused by second-hand cigarette smoke.24 Resveratrol also prevents inflammatory mast cells from releasing the histamines that trigger asthma and allergic reactions.26
Resveratrol radically decreases production of the adhesion molecules that attract inflammatory cells to vascular walls, one of the principal mechanisms of atherosclerosis.27,28 Adhesion molecules also permit cancer cells to invade tissue and metastasize. Resveratrol's influence over NF-kB has also enhanced beneficial UV-induced programmed cell death (apoptosis) in skin cancer cells.29
Found in blueberries, pterostilbene is a polyphenol closely related to resveratrol.30 It limits NF-kB activity through multiple complementary mechanisms.31 In vitro, pterostilbene suppresses invasive tumor activity and enhances therapeutic destruction of cancer cells.32,33
Quercetin's ability to protect against chronic inflammatory conditions such as asthma, inflammatory bowel disease, and arthritis is due in part to its capacity for NF-kB inhibition.34,35
Grape seed extract also disrupts cellular inflammation signaling by blocking NF-kB.36 Its effect on pro-inflammatory cytokine production in fat cells may even help combat obesity and type 2 diabetes.37
Black tea extract's influence on NF-kB activity has been shown to specifically protect cells from damage associated with inflammation,38 cancer,39,40 Parkinson's disease,41 and stroke.42
Suppressing Inflammatory Cytokines
Caloric restriction inhibits expression of genes that produce inflammatory cytokines—such as interleukins and tumor necrosis factor (TNF), as well as cyclooxygenase-2 (COX-2)—that are powerfully implicated in the onset of cancer, atherosclerosis, and chronic inflammation.43-46
Resveratrol and pterostilbene block the release of a host of inflammatory cytokines and enzymes found throughout the body—particularly tissues and organs stressed by environmental factors, infection, or trauma.22,47,48 Pterostilbene powerfully suppresses the expression of inflammatory COX-2,31,49 helping lower the risk of cancer as well as a host of inflammatory diseases.50,51
Quercetin inhibits the COX-2 enzyme involved in early-stage colon cancer, and suppresses numerous cytokines involved in allergies and autoimmune disorders.34,35,53
Grape seed extract specifically prevents fatty tissue from releasing inflammatory cytokines and adipokines that would otherwise provoke insulin resistance and atherosclerosis associated with metabolic syndrome.37 By downregulating reactive cytokines, grape seed extract has been shown in animals to protect organs from ischemia-reperfusion damage (injury caused by the return of blood flow after a period of restriction).54
Black tea extract reduces levels of STAT-1, a protein which "tells" the cell nucleus to activate genes that produce inflammatory cytokines.55


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Victorian Side Table — Free Plan
Subscribers should be receiving the December 2010 issue right now, with Senior Editor Glen D. Huey's impressive Line & Berry Chest on the cover. My mother saw the picture in last week's newsletter and immediately called to ask if I could build one for her. I responded, "We'll see" – which is the same answer she used to give me when I asked for something I wasn't likely to get.
As always, we've added the "I Can Do That" project from the issue to our web site, and it's available free.
The December project is a small Victorian-inspired side table that doubles as a book rack, with a V-shaped shelf below the tabletop. I have a period version of this table in my guest room and when I ran into it with my vacuum cleaner a few months back, I knocked it off the block of wood that's acting as a foot on the end of a broken side, to keep the top level. It was broken when I bought it, and I've been meaning to fix that foot for years. All I need to do is slice the broken bit cleanly off the side, and shape a 3″ or so piece to fix it – how long could that possibly take?!
So I brought the piece into our shop on a Saturday, when I came in to build the I Can Do That project for the December issue. It was supposed to be a rustic "barn bench," and I figured I could fit in the table repair as I waited for glue to dry. But when I turned the table over to get a better look at the area to be repaired, I realized it would make a good ICDT project, so I went rogue and built a reproduction of the table instead. It's an excellent exercise in pattern routing. You can read the story, and download a PDF, here.
I got the ICDT project done in time for the Monday photo shoot, but I did not, however, get around to fixing the period piece. And it was cluttering up my cube. So now it's back in my guest room, balanced atop the block of wood. One of these days, I should get around to fixing it. We'll see.
— Megan Fitzpatrick
• Not a subscriber? Whyever not?! You'll save 47 percent off the cover price!
• Want the December issue? You can buy it online here.
• Get all seven 2010 issues on one CD (it's 400+ pages of pure woodworking information that you can search by keyword, or browse issue by issue). It's just $15.96 – our everyday low savings off the retail price of $19.99.
I kind of love this ICDT. Glad you were inspired to throw caution to the wind and go with your inspiration.
Awesome job with the finish by the way. Looks gorgeous… I know you used pine… is it SYP? Pine in my area just doesn't seem to look that good. What color of gel stain did you use?


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It is not all that odd these days to see someone making a movie in Jamestown. But this week was a bit unusual because there were two different movies being created here on the island at the same time.
You can't miss the big budget Disney/Touchstone movie entourage. There are lots of signs pointing the way to "DIRL," which is short for "Dan in Real Life." The filming is taking place down the street from the Melrose Avenue School. A temporary trailer park has been created for the cast and crew in the parking lot of the Portuguese American Citizens Club.
Meanwhile, a shoestring budget documentary film crew had earlier this week taken over Ft. Getty. They were using the historic replica sloop Providence for shooting "American General." Actors in period colonial uniforms could be seen lounging on the wooden pier alongside the tall sailing ship. The anachronism in the scene was the hazy line of the Jamestown Bridge in the distance.
Yes, we've become somewhat immune to the movie cameras in Jamestown. This past summer Ft. Wetherill was the setting used by an independent movie maker. We all remember not all that long ago when the Farrelly brothers took over Narragansett Avenue and the village for "Me, Myself and Irene." They crashed a police car into the front of what is now the Conanicut Marine Ship's Store. East Ferry became a park with a fountain, and the kids went wild over actor Jim Carrey.
Before that Jamestown hosted dueling twelvemeter sailboats in the Dumplings for the movie "Wind." A film crew transformed a waterfront home with movie magic.
That same location, it is rumored, features the dock and blinking light made famous in the movie "The Great Gatsby."
Scenes for the recent television show "Providence" were filmed in Jamestown. Production crews for PBS and the History Channel have been here a few times. And over the years there have been other movie-makers and documentary crews that have filmed here.
There's no doubt that the Jamestown business community benefits from the local movie-making economics. And the Hollywood types certainly add zest to our sedate island life. Locals get hired as extras and you may occasionally recognize an actor or an actress at a local coffee shop.
Jamestown has become a regular Hollywood East. Maybe the Town Council should establish a Jamestown Film Commission to promote, assist and keep tabs on the movie making here.


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This Week In Island History
The news of 10 and 15 years ago is from the Jamestown Press. The news of 100 years ago came from the collection of the Newport Historical Society.
100 years ago
From the Newport Journal, Sept. 8, 1911
Arrangement have been completed for the play and concert to be given for the purpose of raising money for a new public drinking fountain to be put up by the Improvement Society, and the attendance bids fair to pack the hall to its full capacity.
With the appearance of the sun Friday morning things about the island grew lively again. That only a few of the summer guests had left soon became evident. The rainy weather has caused vegetation to put on a fresh green coloring, and it is doubtful if the island ever looked so well as this time of the year.
75 years ago
From the Newport Daily News, Sept. 8, 1936
The last dance of the season was held at the Beaver Tail (sic) country club Saturday evening, a large number of the summer colony attending. Mrs. Alfred Weeden sang several solos, and a number of Miss Gladding's pupils of Newport entertained with dancing. The Bob Bennett orchestra, which has played at the club during the summer, left Sunday for Philadelphia.
From the Newport Daily News, Sept. 9, 1936
The [Jamestown Garden Club] committee on caterpillar extinction reported that 30 hours of work have been done in removal of web nests and gave plans for interesting both children and adults in an effort to remove the webs this autumn and if necessary in the spring. Prizes will again be offered.
From the Newport Daily News, Sept. 10, 1936
Total elementary enrollment, 302. (The Carr school enrollment is 170; Thomas H. Clarke school, 132.)
Samuel W. Smith Jr., of Jamestown has taken up his duties as landscape engineer in the state division of roads and bridges.
50 years ago
From the Newport Daily News, Sept. 5, 1961
Scott Jones and Judy Zenie walked off with top honors in Jamestown's annual Mackerel Cove Labor Day swimming meet, scoring the most points among the boys and girls to gain the trophies.
From the Newport Daily News, Sept. 6, 1961
The right of 17 Jamestown residents to sue the Commerce Oil Corp. for $100,000 each was upheld today by Judge Edward A. Day in U.S. District Court in Providence.
From the Newport Daily News, Sept. 7, 1961
French will be taught after regular school hours at the Jamestown School by John E. Merker, instructor. Only children of grades 3, 4 and 5 are included.
25 years ago
From the Newport Daily News, Sept. 5, 1986
The state may have to provide residents near the new Route 138 cross-island road with outside drinking water during construction of a storm water drainage tunnel.
From the Newport Daily News, Sept. 8, 1986
(Photo caption) Renovations continue on historic Bay View Inn in Jamestown.
(Photo caption) Carpenter Jim Kennedy puts on cedar shingles.
15 years ago
From the Jamestown Press,
Sept. 6, 1996
Hurricane Edouard turned out to be not much more than a Northeaster, and while it ruined the Labor Day weekend, town officials this week had little damage to report. Harbormaster Sam Paterson said that a 35-foot sailboat off a private mooring went aground just north of Green's Pier in the East Passage. Four boats went aground in the West Passage, including two sailboats in the 30-foot range and two powerboats.
One of Jamestown's rare jewels will be polished this weekend when volunteers clean and repair the medical supplies storage closet this Saturday and Sunday. Town officials allocated $1,500 from the capital budget for repair to the building.
10 years ago
From the Jamestown Press, Sept. 6, 2001
Of the more than 2,000 homes on the island only seven of them are set aside for low income islanders. Rhode Island Housing community profile of the island last year said that 1.182 island families fall within the limits set for low and moderate income households and that the fair market rent for a typical two-bedroom apartment is $632 a month.
On Monday, the Town Council will be presented with a petition asking that the fire department's alarm horn be silenced.


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WASHINGTON — Congress approved legislation last week to fund the federal government for another six months, averting a shutdown and softening the impact of automatic across-the-board spending cuts required under sequestration.
The federal government has been operating under a series of short-term spending resolutions since the 2013 fiscal year began in October. The latest one expires Wednesday .
The $984 billion spending bill will keep the government funded through the end of the fiscal year on Sept. 30. It includes $85 billion in automatic spending cuts triggered earlier this month under a 2011 debt limit agreement.
The final bill, however, also eases the blow of the so-called sequestration cuts by including additional funding for military operations as well as a measure to ensure meat and poultry inspectors are not furloughed.
Despite lobbying from individual lawmakers, Congress did not restore funds to keep air traffic control towers open at smaller airports. It also did not provide funds to reopen public tours of the White House.
The Senate voted for the bill, 73-26. Sen. Harry Reid, D-Nev., voted in favor. Sen. Dean Heller, R-Nev., opposed it.
The House approved the bill, 318-109. Reps. Joe Heck, R-Nev., Steven Horsford, D-Nev., and Dina Titus, D-Nev., voted in favor. Rep. Mark Amodei, R-Nev., did not vote.
Debate over the 2014 budget took a partisan divide last week as the House and Senate disagreed on how to reduce future deficits.
The House approved a budget resolution by Rep. Paul Ryan, R-Wis., that would eliminate annual deficits in a decade through cuts in nondefense programs. It also called for a tax system overhaul and a restructuring of Medicare.
Republicans said the measure was tough but necessary to control government spending and foster economic growth. Democrats uniformly opposed the Ryan budget, calling it misguided and ruinous.
"Once again, House Republicans doubled down on a budget that will risk 2 million jobs next year, stall our economic recovery, raise taxes on the middle class, and end the Medicare guarantee. That is not a 'path to prosperity;' it is a 'path to pain' for working families, children, seniors and our economy," said Rep. Nancy Pelosi, D-Calif.
The House approved the resolution, 221-207, with 197 Democrats and 10 Republicans in opposition.
Heck, Horsford and Titus opposed the resolution. Amodei did not vote.
At about 5 a.m. EDT Saturday, the Senate voted 50-49 to pass a budget resolution proposed by Sen. Patty Murray, D-Wash., that would reduce — but not eliminate — annual deficits.
Reid voted for the Senate budget resolution. Heller voted against it.
The plan calls for about $1 trillion in spending cuts and $1 trillion in tax hikes over 10 years.
House Speaker John Boehner, R-Ohio, lashed out at Senate Democrats for considering a budget that "never balances — ever."
The Senate debate began Thursday and included votes on dozens of nonbinding amendments mostly designed to score political points ahead of the 2014 elections.
Among the amendments, the Senate voted against the Ryan budget, 40-59.
Reid and Heller opposed it.
The Senate voted against repealing President Barack Obama's signature Patient Protection and Affordable Care Act, 45-54.
Heller voted for repeal. Reid opposed repeal.
And, the Senate rejected, 45-54, a measure to prohibit tax increases when the unemployment rate exceeds 5.5 percent.
Heller voted for it. Reid voted against the proposal.
Contact Stephens Washington Bureau reporter Peter Urban at email@example.com or 202-783-1760.


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Summerlander wrote:
Scientists have phone that if people stop thinking too hard about solving a problem and just let the "unconscious" side take over, those eureka moments will come unexpectedly! We have to remember that the higher cortical areas do a lot of thinking but are slow to act (slow response). However, closer to the primordial layer, there is not much thinking (dead zone) but the response is fast and intuitional. While the neocortex is more constrained by thinking patterns, the lower one contains a subconscious see of information where anything goes, and this zone often makes associations between concepts that the logical side wouldn't normally do.
[ Post made via Android ]
Thanks for sharing that.
HAGART wrote:
I never thought of that, but I suppose you're right. It would get boring if they always knew it was a dream and your lucid powers and 'magic tricks' never impressed them. That's some of my favorite things to do when I become lucid around others in a dream. I like to show off my 'powers'. But I've had some dreams where they DC's are aware it's a dream, and they are not impressed.
Exactly. It's rare that I get to impress them, but it's fun! I wonder if I asked them to 'be dumb unless I tell you otherwise' what they would do. I enjoy the looks they give in those circumstances when you suddenly hover off the floor. However if I did that, I don't think it would be the same. I'd know they were just acting surprised based on how they are usually. That or they would just ask why and I would be like "Because I want to see your surprised face when I...Um, I mean I want to act all awesome and watch as you...freak out... OH YOU KNOW WHAT NEVER MIND!!!" . So to all of you who take them for granted, enjoy your 'zombies'! They're pretty darn fun!


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Barcelona delivered a masterclass to inflict another Champions League final defeat on Manchester United as Lionel Messi inspired an emphatic victory at Wembley.
Manchester United's hopes of emulating their first European Cup final success here against Benfica in 1968 foundered as Barcelona deservedly repeated their win against Sir Alex Ferguson's side in Rome two years ago. Continue reading


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Winter just got a little easier for Derry Public Works
July 10. 2013 8:21PM
DERRY — Thanks to a state grant program, the Department of Public Works could have a pair of new and efficient one-ton trucks before the snow starts falling this winter.
On Tuesday night, the Town Council voted, 6-1, to accept a state Department of Transportation grant that will cover 80 percent of the trucks' cost, with Mark Osborne the only councilor voting against the plan.
The DOT grant program dates back to 2010 and is intended to lower chloride levels from winter road salting in conjunction with the Interstate 93 widening project. Salem, Windham and Londonderry have also received funds through the program.
Public Works Director Mike Fowler said town generated a salt management plan in 2010, making the town eligible for the grants.
"Round one funding was approved by the town in January 2010 for the purchase of a five-ton truck with the town of Derry responsible for 20 percent of the cost and the state of New Hampshire reimbursing 80 percent of the cost," said Fowler. "Round two funding was approved by the Town Council in June 2012 for the purchase of two additional five-ton trucks under the same cost share formula."
The state will also pay for 80 percent of the cost of the two one-ton trucks, which are designed to reduce salt usage during the winter. The trucks are equipped with front plows, wing plows, ground speed control and spreaders that include brine saddle tanks for pre-wetting the road.
Fowler said the pre-wetting prevents the salt from bouncing off the road and onto the sides of the street. The ice and snow control methods are designed to reduce salt usage by 20 percent, said Fowler.
"The total cost for each truck is $81,500, for a total cost of $163,000," said Fowler. With the 80 percent reimbursement, the town will pay $32,600 for the new trucks.
"The town has greatly modernized its truck fleet through this grant program," said Fowler. "Five trucks that were originally scheduled for replacement in the fiscal years 2012-16 will be replaced sooner, utilizing the financial leverage of the grant funds."
The two trucks that will be replaced could either be auctioned off or used by another town department, said Fowler.
Town Councilor Al Dimmock said he wholeheartedly supported the grant, noting that the current one-ton trucks used by Public Works do not have the features of the proposed new trucks.
"If we do not get them now, we will not have the grant to get them later," he said. "Then we're going to have to pay for the whole shooting match."


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BRISTOL, Tenn. - King College head softball coach Jenn Testa recently announced the signing of five players from the state of Virginia.
Three of the five, Fallon Thomas (Bristol, Va.), Crystal Bullock (Bristol, Va.) and Adrianne Evans (Bristol, Va.) graduated from Virginia High School. Lauren Wilson (Abingdon, Va.) and Cassie Ringstaff (Richlands, Va.) completed the Virginia class.
Thomas was a four-time all-region selection and was the Region 'D' Player of the Year as a sophomore and junior. She also collected the Group 'A' Virginia Player of the Year honor in 2009 and was an all-state selection in 2008 and 2009. Four times she was on the all-district first team and earned district player of the year honors twice including the Clinch Mountain Player of the Year nod in 2009. Thomas was selected to play in both the FCA and VHSCA All-Star games this past season.
Evans was an All-Clinch Mountain District and All-Region 'D' first team selection in 2010. She won Virginia High's most improved player as well.
Bullock played on Virginia High's varsity squad for four seasons and collected the 2009 Virginia High's Most Improved honor.
The three was a part of Virginia High's winningest class in program history as the 2010 seniors went 84-18 with three trips to the VHSL Final Four, four VHSL State Tournament appearances, two region crowns and four district titles
Ringstaff, a member of Richlands High's softball squad was a four-time All-Southwest District selection. She also made the all-region squad first team twice and twice on the second team. Ringstaff played in the Virginia High School Coaches Association All-Star Game in 2010 at second base. She also added spots on the Associated Press All-Area Southwest Virginia team in 2007 and 2008.
Wilson played at Abingdon High and earned all-district and all-region honors in all four seasons of her prep career. She also won the Abingdon High School Best Offensive Player award from 2008 to 2010.
King finished the 2010 season with a trip to the NCCAA World Series where the team finished tied for fifth. The Lady Tornado posted a record of 22-17 which was the third straight 20-win season in the program's six-year history.


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2 days ago
NZ Residents pip Aussie Schoolboys at the post
An early try to Australian Pat Mata'utia in the opening minutes of the game, followed in quick succession by team mate Nene McDonald certainly did not dispel the NZ Resident 18s hunger for a win.
The youngsters, who only joined each other in camp for the very first time this week, fought hard in wet and windy conditions at Bruce Pulman Park in Papakura, with a come-back try by David Fusitu'a (Auckland Pride), which was successfully converted by Honeti Tuha (Counties Manukau). Only a few moments later Counties Manukau player Trent Bishop crossed the line to bring the score to 14 - 10 to Australia at half time.
An injury to star player Viliami Lolohea early in the 2nd half only pushed his team mates to play harder with Esera Esera (Auckland Pride), Trent Bishop and Kurt Robinson (Wellington Orcas) all crossing to score only moments apart.
Even with a last minute try to Australian Jake Trbojevic, when the final whistle blew, the NZ Resident side had proven to strong for the Australian Secondary Schoolboys, nudging them out of a win with a final score of 28 - 26.
Tony Kemp, NZRL Football Manager said,


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Oil ends week down 2 pct on tepid demand outlook
The Associated Press
May. 24, 2013
NEW YORK (AP) — The price of oil fell 2 percent this week, as oil traders worried about global demand and shared the stock market's concerns about possible changes to the Federal Reserve economic stimulus program.
The loss Friday was just 10 cents, to $94.15 a barrel. But four straight losses resulted in a weekly decline of $1.87 a barrel for the benchmark oil contract.
The global economic picture was clouded by weak manufacturing data from China. That raised questions about the strength of oil demand in the world's No. 2 economy. In the U.S., a report from the Energy Department showed the country is well-supplied with oil, and gasoline demand remains below year-ago levels.
One question overhanging the market is what the Federal Reserve's next moves will be with its monetary policy. Recent comments from Fed policy makers, including Chairman Ben Bernanke, raised concerns that the Fed will scale back its effort to support the economy sooner than traders had expected.
The uncertainty led U.S. stock markets to their first weekly loss in a month. Oil tracked stocks for most of the week, as oil traders looked to their equities counterparts for clues on how to react to the Fed.
Brent crude, a benchmark for many international oil varieties, rose 20 cents to $102.64 a barrel on the ICE Futures exchange in London.
In other energy futures trading on Nymex:
— Wholesale gasoline rose 1 cent to $2.84 a gallon.
— Heating oil was flat at $2.86 a gallon.
— Natural gas fell 2 cents to $4.24 per 1,000 cubic feet.
Pablo Gorondi in Budapest and Pamela Sampson in Bangkok contributed to this report.


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Zooey Deschanel to Star in Coal Miner's Daughter
On Broadway.
Zooey Deschanel will play Loretta Lynn in an upcoming Broadway staging of Coal Miner's Daughter, Lynn announced at a concert at the Grand Ole Opry last night. She then brought Deschanel onstage, and the two sang a duet together. ("There's a little girl backstage that's going to do the play of Coal Miner's Daughter," Lynn said by way of introduction.) The details of the show — like who's writing and directing it, or when it will be staged — haven't been announced yet, but this will mark Deschanel's Broadway debut.


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Committee Membership Information
Study Title:
Evaluating the Effectiveness of the Global Nuclear Detection Architecture
Primary Board:
Study Director:
Dr. Arden L. Bement, Jr.
- (Chair)
Purdue University
Arden Bement is the founding director of the Global Policy Research Institute and is the David A. Ross Distinguished Professor of Nuclear Engineering at Purdue University. He served as director of the National Science Foundation (NSF) from 2004 until 2010. Prior to his confirmation as NSF director, Dr. Bement served as director of the National Institute of Standards and Technology (NIST). He has held previous appointments at Purdue University in the schools of Nuclear Engineering, Materials Engineering, and Electrical and Computer Engineering, as well as a courtesy appointment in the Krannert School of Management. Dr. Bement joined the Purdue faculty in 1992 after a 39-year career in industry, government and academia where his positions included: vice president of technical resources and of science and technology for TRW Inc.; deputy under secretary of defense for research and engineering; director, Office of Materials Science at DARPA; and professor of nuclear materials at the Massachusetts Institute of Technology. He served as a member of the U.S. National Commission for UNESCO and as the vice-chair of the Commission's Natural Sciences and Engineering Committee. He is a member of the National Academy of Engineering, a fellow of the American Academy of Arts and Sciences, and a fellow of the American Association for the Advancement of Science. Dr. Bement has served on and has chaired numerous NRC studies, most relevant to this study chairing the Committee on the Scientific and Technical Assessment of Stockpile Stewardship. Dr. Bement is a retired lieutenant colonel of the U.S. Army Corps of Engineers, and a recipient of the Distinguished Civilian Service Medal of the Department of Defense. He received his B.S. in engineering of metallurgy from the Colorado School of Mines, his M.S. in metallurgical engineering from the University of Idaho, his Ph.D. in metallurgical engineering from the University of Michigan, and honorary doctorates from Cleveland State University, Case Western Reserve University, the Colorado School of Mines, the University of Idaho and the Korean Advanced Institute of Science and Technology, as well as a Chinese Academy of Sciences Graduate School Honorary Professorship. He has been awarded the Order of the Rising Sun, Gold and Silver Star, from the Empire of Japan and the Chevalier dans l'Ordre National de la L??gion d'Honneur from the French Republic.
Dr. Thomas C. Schelling
University of Maryland, College Park
Dr. Thomas Schelling is a Distinguished Professor of Economics at the University of Maryland. In 2005, he was awarded the Nobel Prize in Economics for enhancing the "understanding of conflict and cooperation through game-theory analysis." In 1990, he left the John F. Kennedy School of Government, where he was the Lucius N. Littauer Professor of Political Economy. He has also served in the Economic Cooperation Administration in Europe and has held positions in the White House and Executive Office of the President, Yale University, the RAND Corporation, and the Department of Economics and Center for International Affairs at Harvard University. Most recently, he has published on military strategy and arms control, energy and environmental policy, climate change, nuclear proliferation, and terrorism. Dr. Schelling is best known for his books The Strategy of Conflict and Micromotives and Macrobehavior. He is a member of the National Academy of Sciences, the Institute of Medicine, and a fellow of the American Academy of Arts and Sciences. In 1991, he was President of the American Economic Association, of which he is now a Distinguished Fellow. He was the recipient of the Frank E. Seidman Distinguished Award in Political Economy and the National Academy of Sciences award for Behavioral Research Relevant to the Prevention of Nuclear War. He has served on numerous NRC committees, most relevantly the Roundtable on Social and Behavioral Sciences and Terrorism. Dr. Schelling received his B.A. in economics from the University of California, Berkeley and his Ph.D. in economics from Harvard.
Dr. John Mattingly
North Carolina State University
Dr. John Mattingly recently joined the North Carolina State University (NCSU) where he is conducting basic research in radiation measurement and analysis methods applied to nuclear security applications, including nuclear materials control and accountability (NMC&A), arms control, safeguards, nonproliferation, counterterrorism, emergency response and forensics. Prior to joining the NCSU faculty, he worked for 15 years at two national laboratories, Oak Ridge National Laboratories (ORNL) and Sandia National Laboratories (SNL). At ORNL, he helped to develop measurement systems and analysis methods for active neutron interrogation of special nuclear material for NMC&A, safeguards, arms control, and nonproliferation applications. This work included conducting experiments at several facilities in the US nuclear weapons complex, and at foreign facilities including the Russian Institute of Experimental Physics (VNIIEF). At SNL, Dr. Mattingly was one of two lead developers of the Gamma Detector Response Analysis Software (GADRAS) which is commonly used by the on-call analyst community to simultaneously analyze gamma spectroscopy and neutron multiplicity counting measurements. At SNL, he also served as a 24/7 on-call analyst for the Department of Energy (DOE) and Department of Homeland Security. In this job, he learned to rapidly analyze gamma spectroscopy and neutron multiplicity measurements to assess the potential threat posed by a radiation source discovered in the stream of commerce and other settings. Dr. Mattingly received his B.S., M.S. and Ph.D. all in nuclear engineering at the University of Tennessee.
Mr. John M. Holmes
Port of Los Angeles, California
As deputy executive director of operations at the Port of Los Angeles, Capt. John M. Holmes oversees the Port Police, Port Pilots, Emergency Preparedness, Wharfinger and Homeland Security divisions at one of the busiest container ports in the nation. He works cooperatively with associated government and law enforcement agencies to uphold maritime laws, enforce safety and security regulations, and continually test and enhance emergency response and preparedness procedures to ensure the safety of the Port workforce and residents in the surrounding harbor communities. Capt. Holmes has 30 years of international management experience in a variety of positions that include a chief operating officer, Fortune 500 executive, senior level Coast Guard officer and industry renowned maritime security specialist. As Captain of the Port of Los Angeles, Holmes was at the helm on September 11, 2001, and has been credited with swift and decisive actions that ultimately led to the creation of a number of national security initiatives, including the Maritime Transportation Security Act (MTSA), Area Maritime Security Committee and Sea Marshal Program. He most recently served as a principal and chief operating officer of the Marsec Group, a full-service security consulting firm specializing in supply chain security, technology and operations. Prior to forming the Marsec Group, Holmes was vice president and director of business development for Science Applications International Corporation, where he assisted government and commercial customers with the development of technological solutions to homeland security challenges, with an emphasis on port, border and military solutions. His most relevant NRC committee membership was serving on the Committee on Evaluating Testing, Costs, and Benefits of Advanced Spectroscopic Portals. Capt. Holmes holds B.A. in English and education from Boston College, and an M.S. in business administration from Washington University???s John M. Olin School of Business.
Dr. Detlof von Winterfeldt
University of Southern California
Prior to returning to the University of Southern California (USC), where he is a professor of Industrial and Systems Engineering and a Professor of Public Policy and Management, Dr. Detlof von Winterfeldt served as the director of the International Institute for Applied Systems Analysis (IIASA) in Laxenburg, Austria. Concurrently with his term at IIASA, he was a Centennial Professor in the Operational Research Group of the School of Management in the London School of Economics and Political Science. In 2003 he co-founded the National Center for Risk and Economic Analysis of Terrorism Events (CREATE) at USC, the first university-based center of excellence funded by the U.S. Department of Homeland Security. He served as CREATE???s director until 2008. For the past thirty years he has been active in teaching, research, university administration, and consulting. His research interests are in the foundation and practice of decision and risk analysis as applied to technology development, environmental risks, natural hazards and terrorism. He is the co-author of two books, two edited volumes, and author or co-author of over 100 journal articles and book chapters on these topics. He is a former president of the Decision Analysis Society of the Institute for Operations Research and Management Science (INFORMS) and is an elected fellow of INFORMS and of the Society for Risk Analysis. In 2000 he received the Ramsey Medal for distinguished contributions to decision analysis from the Decision Analysis Society of INFORMS. In 2009 he received the Gold Medal from the International Society for Multicriteria Decision Making for advancing the field. He has served on numerous committees and panels of the NRC and the U.S. National Science Foundation; most relevant to this study was his service on the NRC???s Committee on Transportation of Radioactive Waste. He received his B.S. in psychology with a minor in philosophy and his M.S. in psychology from the University of Hamburg, Germany, and his Ph.D. in mathematical psychology from the University of Michigan.
Dr. Martha Crenshaw
Stanford University
Dr. Martha Crenshaw is a senior fellow at the Center for International Security and Cooperation (CISAC), a senior fellow at the Freeman Spogli Institute for International Studies (FSI), and a professor of political science by courtesy at Stanford University. She was the Colin and Nancy Campbell Professor of Global Issues and Democratic Thought and professor of government at Wesleyan University from 1974 to 2007. She chaired the American Political Science Association Task Force on Political Violence and Terrorism. She was also a lead investigator at the National Consortium for the Study of Terrorism and Responses to Terrorism (START), a center of excellence of the Department of Homeland Security based at the University of Maryland. She has long written extensively on the issue of political terrorism; in 2011, Routledge published Explaining Terrorism, a collection of her previously published work beginning with her 1972 article, "The Concept of Revolutionary Terrorism." She was a Guggenheim Fellow in 2005. Dr. Crenshaw has served on several NRC committees, most relevantly: the Committee on Determining Basic Research Needs to Interrupt the Improvised Explosive Device Delivery Chain. She received her B.A. from Newcomb College and an M.A. from Wesleyan University. She received her second M.A. and her Ph.D., both in political science, from the University of Virginia.
Dr. Roger L. Hagengruber
The University of New Mexico
Dr. Roger Hagengruber is the director of the Office for Policy, Security and Technology, the Institute for Public Policy, and a professor of political science at the University of New Mexico. Dr. Hagengruber previously served as senior vice president at Sandia National Laboratories. During his 30 years at Sandia, he concentrated on non-proliferation issues and served as a negotiator in Geneva and the Soviet Union. Most recently, he co-authored the report: ???Nuclear Power and Proliferation Resistance: Securing Benefits, Limiting Risk,??? which was published by the Nuclear Energy Study Group of the American Physical Society. His most recent and relevant NRC committee membership was serving on the Committee on Evaluating Testing, Costs, and Benefits of Advanced Spectroscopic Portals and the Committee on Risk-Based Approaches for Securing the DOE Nuclear Weapons Complex. He received his B.S., M.S and Ph.D. from the University of Wisconsin System. His Ph.D. is in nuclear physics.
Dr. Donald Prosnitz
The RAND Corporation
Dr. Prosnitz is presently a Sr. Principal Researcher (adjunct) at RAND Corporation, a visiting scholar at the physics department of the University of California, Berkeley, and an independent technical consultant. His current activities include research on free-electron lasers and a range of studies at RAND concentrating on the utilization of technology to solve national and homeland security issues. Dr. Prosnitz was previously the Deputy Associate Director (Programs) for Non-Proliferation, Homeland and International Security at Lawrence Livermore National Laboratory (LLNL) where he was responsible for overseeing all of the directorate???s technical programs. He spent two years as an assistant professor at Yale University before joining LLNL. Over the next three decades, he conducted research on lasers, particle accelerators, high power microwaves, free electron lasers, and remote sensing, and managed the design, construction, and operation of numerous research facilities. In 1990, he was awarded the U.S. Particle Accelerator Award for Achievement in Accelerator Physics and Technology. In 1999, Dr. Prosnitz was named the first Chief Science and Technology Advisor for the Department of Justice (DOJ) by Attorney General Janet Reno. He was responsible for coordinating technology policy and technology projects among the DOJ???s component agencies and with state and local law enforcement entities. In 2002, he was named a Fellow of the American Physical Society. He is a former chair of the American Physical Society Forum on Physics and Society. He recently served on the NRC Committee to Review the Department of Homeland Security???s Approach to Risk Analysis. Dr. Prosnitz received his B.S. from Yale University and his Ph.D. in Physics from the Massachusetts Institute of Technology. He is a licensed amateur radio operator and an active member of his community???s CERT (Community Emergency Response Team.)
Dr. Edward H. Kaplan
Yale School of Management
Dr. Edward Kaplan currently serves as the William N. and Marie A. Beach Professor of Management Sciences at the Yale School of Management, Professor of Public Health at the Yale School of Medicine, and Professor of Engineering in the Yale School of Engineering and Applied Sciences. He is an expert in operations research, mathematical modeling and statistics and studies problems in public policy and management. His recent research has focused on counterterrorism topics such as the tactical prevention of suicide bombings, bioterror preparedness, and response logistics in the event of a smallpox or anthrax attack. He has received three Koopman Prizes from the Institute for Operations Research and the Management Sciences (INFORMS) Military Applications Society, one for his work on smallpox , another for his models evaluating suicide-bomber-detector schemes and most recently for his paper ???Terror Queues,??? which was won in 2011. Dr. Kaplan co-directs the Daniel Rose Technion-Yale Initiative in Homeland Security and Counterterror Operations Research. He served twice as the Lady Davis Visiting Professor at the Hebrew University of Jerusalem???in the School of Public Health and Community Medicine in 1994, and in the Department of Statistics in 1997???and is also an elected member of the Board of Governors of the Technion-Israel Institute of Technology. For all of his contributions to the operations research profession, Kaplan was designated an INFORMS Fellow in November 2005 and is a member of both the National Academy of Engineering and the Institute of Medicine. He has served on numerous NRC committees, most relevently on the Committee on Behavioral and Social Research to Improve Intelligence Analysis for National Security. He obtained his B.A. from McGill University with First Class Honors in economic and urban geography, and proceeded to graduate study at the Massachusetts Institute of Technology where he completed three masters??? degrees (in operations research, city planning, and mathematics) in addition to his doctorate in urban studies.
Dr. James S. Dyer
The University of Texas at Austin
Dr. James S. Dyer holds the Fondren Centennial Chair in Business in the College of Business Administration at the University of Texas at Austin. In 1999, he received the College of Business Administration Foundation Advisory Council Award for Outstanding Research Contributions. He served as chair of the Department of Information, Risk, and Operations Management for nine years (1988-97). He was the Philip J. Rust Visiting Professor of Business at the Darden Business School at the University of Virginia in 1999. He is the former president of the Decision Analysis Society of the Operations Research Society of America (now INFORMS). He received the Frank P. Ramsey Award for outstanding career achievements from the Decision Analysis Society of INFORMS in 2002. He was named a fellow of INFORMS in 2006 and also received the Multiple Criteria Decision Making Society???s Edgeworth-Pareto Award in 2006. Dr. Dyer has consulted with a number of companies regarding the application of decision and risk analysis tools to a variety of practical problems, including the Jet Propulsion Laboratories, the RAND Corporation, and the Department of Energy. Dr. Dyer has published three books and more than 60 articles on risk analysis and investment science. His recent articles focus on decision making including a multi-attribute utility analysis for the disposition of weapon-grade plutonium in the United States and Russia. He received a B.A. with honors, Phi Beta Kappa, in physics with minors in mathematics and philosophy and his Ph.D. in business quantitative methods and management from the University of Texas at Austin.
Dr. Gregory Parnell
U.S. Army Military Academy
Dr. Gregory S. Parnell is a professor of systems engineering at the U.S. Military Academy at West Point and is now on sabbatical as a Distinguished Visiting Professor at the U.S. Air Force Academy. His research focuses on decision analysis, risk analysis, resource allocation, and systems engineering for defense; intelligence; homeland security; research and development; and environmental applications. He is Chairman of the Board and a senior principal with Innovative Decisions, Inc., a decision and risk analysis firm. Dr. Parnell is a former president of the Decision Analysis Society of the Institute for Operations Research and Management Science (INFORMS) and of the Military Operations Research Society (MORS). He has also served as editor of Journal of Military Operations Research. Dr. Parnell has published more than 100 papers and book chapters and has co-edited Decision Making for Systems Engineering and Management, Wiley Series in Systems Engineering (2nd Ed, Wiley and Sons, 2011). He has received several professional awards, including the U.S. Army Dr. Wilbur B. Payne Memorial Award for Excellence in Analysis, MORS Clayton Thomas Laureate, two INFORMS Koopman Prizes, and the MORS Rist Prize. He chaired the NRC Committee on Methodological Improvements to the Department of Homeland Security's Biological Agent Risk Analysis (2008) and was a member of the Improving Metrics for the Department of Defense Cooperative Threat Reduction Program (2011). He is a fellow of MORS, INFORMS, the International Committee for Systems Engineering, and the Society for Decision Professionals. He received his B.A. in aerospace engineering from the State University of New York at Buffalo, his M.E. in industrial and systems engineering from the University of Florida, his M.S. in systems management from the University of Southern California, his Ph.D. in engineering-economic systems from Stanford University. Dr. Parnell is a retired Air Force colonel and a graduate of the Industrial College of the Armed Forces.
Ms. Kelley S. Coyner
University of Maryland at Baltimore
As a senior researcher at the University of Maryland Center for Health and Homeland Security, Kelley Coyner serves as the Chief of Staff of the Senior Policy Group of the National Capital Region. In this capacity ,she creates and facilitates multi-agency teams to oversee the selection, implementation, and evaluation of federal funded projects across all levels of government and more than 20 disciplines. She is an expert in the development and implementation of strategic planning for technically and social complex fields; designing, implementing and evaluating, complex programs and policies across disciplines; and fostering innovation through public policy. Her previous work in emergency preparedness and response includes serving as the senior official in charge of emergency preparation and response at the Department of Transportation; civilian advisor to the U.S. Coast Guard Academy on coordinated disaster response (2001); visiting researcher at MIT's Center for Transportation Research (2001-2002); and observer, Executive Session on Domestic Preparedness at the Kennedy School of Government at Harvard University (2001-2003). Ms. Coyner???s six years as a senior official at DOT included service as the Senate-confirmed Administrator of the Research and Special Programs Administration. For her work in technology, transportation, and education, she received the Secretary???s Gold Medal. From 2001 to 2006, Ms. Coyner lived in Bolivia and Paraguay where she served as an advisor to local and international nonprofits on institutional development, conservation, community health, disaster relief, and risk mitigation. Ms. Coyner has served as an Ex-Officio member of the NRC???s Transportation Research Board. She received her B.S. from Georgetown University???s School of Foreign Service and the Dean???s award for outstanding public service. A graduate of University of Virginia School of Law, Ms. Coyner clerked for Hon. George P. Kazen, Chief Judge (ret.), U.S. District Court, Southern District of Texas and practiced with the Arent Fox law firm.


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Necrotizing Enterocolitis
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It's holiday season, and in the food blogging world that means only one thing: Menu for Hope.
Menu for Hope is an annual charity raffle hosted by Chez Pim for which food bloggers around the globe donate incredible food and drink-themed prizes. Proceeds from this year's auction will once again benefit the UN World Food Programme's school lunch programme in Lesotho.
You can help by choosing your favourite prizes, making a large donation here, then entering your raffle tickets in the draws for those prizes. For a complete list of prizes, including items from Canadian bloggers, visit the following sites:
Canada: Meena Agarwal of Hooked on Heat
US: West (Closer to SF than to NY.): Matt Armendariz of Matt Bites
U.S. East (Closer to NY than to SF.): Jaden Hair of Steamy Kitchen
Europe: Sara of Ms.Adventures in Italy
Asia Pacific, Australia, New Zealand: Ed Charles of Tomato
Special Wine Blog Host: Alder of Vinography
For complete information on how to make a donation, check out the instructions at the end of this post.
Rachel and I are proud to contribute an autographed copy of A Day at elBulli, the latest volume from Ferran Adria, the world's most famous chef. A Day at elBulli is a photo-essay of a service at elBulli interspersed with recipes, menus, and musings. Chef Adria autographed this copy during his visit to Toronto in October.
If you're looking for the perfect gift for the cookbook collector or molecular gastronomy geek in your life, look no further. Let it ride on prize CA02, the prize code for this autographed copy of a remarkable book that we will ship anywhere in Canada or the United States.
And please help a great cause in the process.
Donation Instructions:
1. Choose a prize or prizes of your choice from our Menu for Hope at http://www.chezpim.com/
2. Go to the donation site at http://www.firstgiving.com/menuforhope5 and make a donation.
3. Each $10 you donate will give you one raffle ticket toward a prize of your choice. Please specify which prize you'd like in the 'Personal Message' section in the donation form when confirming your donation. You must write-in how many tickets per prize, and please use the prize code.
For example, a donation of $50 can be 2 tickets for EU01 and 3 tickets for EU02. Please write 2xEU01, 3xEU02
4. If your company matches your charity donation, please check the box and fill in the information so we could claim the corporate match.
5. Please allow us to see your email address so that we could contact you in case you win. Your email address will not be shared with anyone.


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What is TV Genie?
TV Genie is a free application that allows you to turn off the lights when watching videos on your favorite websites.
How does it work?
When TV Genie is running you'll find a new light switch button on eligible websites, which looks like this:
What browsers do you support?
Internet Explorer 8+, and the latest few versions of FireFox and Google Chrome. We currently only support Microsoft Windows operating system (check back in the future for Mac support!)
Where can I get install instructions for my browser?
You can get a quick, simple set of instructions for installing TV Genie using your current browser via our Install Steps page.
Is TV Genie safe to use?
Yes, TV Genie is safe to use and was built with security and privacy as a primary concern.
Is TV Genie free?
Yes, TV Genie is entirely free to use. In order to keep TV Genie free, we've partnered with high-quality ad providers and you may see additional ads when TV Genie is installed. We do not allow any really annoying ads, sexual content, or intrusive media; we've only partnered with high-quality ad providers to deliver the best user experience possible, while also trying to help with some of our costs to keep TV Genie free. If you find any ads annoying, please let us know.
What exactly gets installed on my computer?
All of the files for TV Genie are installed in the standard program files location - there is no funny business or extra files added. Included in those files is an un-installer that is also registered to appear in your computer's 'Control Panel > Add/Remove Programs' section. There are also a few registry settings added to your Windows Registry that are required for the normal operation of your app, but there is nothing strange or out of the ordinary here, either.
What are additional offers?
In some cases, we may display product offers during your installation process. Of course, you will have the ability to accept or pass on these offers. We try our very best to make sure any product offering follows best practices and actually provides something of value to you. For example, you may be given the option to install a search toolbar during installation, which looks like this:
These offers make it more efficient to search the web by providing you with multiple places to search from (an additional search field, your home page or via opening a new browser tab). Included with these toolbars are typically widgets that provide new ways to access your favorite websites, social networking platforms and news sources. They also may offer general utility widgets like getting real-time weather data and streaming your radio station of choice. At any point, if you decide to uninstall TV Genie, instructions for how to uninstall additional offers will also be provided.
If I don't like it, is it easy to uninstall?
Yes, we strive to make uninstalling TV Genie as easy as possible (we hate annoying un-installers as much as you do). If you don't like TV Genie (but we're sure you will!), you can uninstall with no trace left behind. In order to do this, please follow these steps:
- Windows Control Panel: Click Start > Control Panel > Add / Remove Programs > TV Genie
What happens if I have a problem uninstalling?
We strive to make uninstalling TV Genie as simple as possible. Sometimes third party programs, such as security or uninstall utilities will prevent this from happening. This may cause error messages or prevent the uninstaller from opening. The easiest solution is to temporarily disable this software or use Windows Safe Mode to allow the uninstall process to complete.
If you still have issues, please let us know. The more details you can provide, the better we'll be able to assist you. This would include specific error messages and any steps you have already tried out.
Sounds Awesome! But, I have some more questions!
We'd love to help. For questions, comments or support, we provide the following options:
Email: email@example.com
Physical Mail Address:
1155 Camino Del Mar, Suite 129
Del Mar, CA 92014-2605


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Details are scarce, but we know for now that two dozen or more people have been injured in multiple bombing attacks in the eastern Ukrainian city of Dnepropetrovsk. The first bomb struck mid-day at a crowded trolleybus stop in the city center, and three more explosions are believed to have occurred in central locations soon afterward. Throughout the afternoon and evening, local residents and security services have been seen rounding up trashcans from public places, for fear they might be used to conceal another bomb.
How can these shocking acts be explained? More information will surely become available as an official investigation gets underway, but for now, there are several very troubling possibilities, each of which at least bears careful consideration by the Ukrainian authorities and the public.
The bombings could simply have been random acts of violence, or the work of criminal gangs. Last year, criminals set off smaller bombs in another eastern Ukrainian city, and threatened much larger explosions if a ransom of 4 million Euros was not paid. Bombings and shootings are relatively common in connection with Ukraine's criminal underworld and endlessly feuding oligarchs, however it is unlikely that such large and indiscriminate attacks were meant simply to assassinate any particular individual.
The chaos around these bombings might have helped to obscure a targeted killing, but it will also surely attract far greater police attention as a result. The attacks might also have been a message meant for one of Dnepropetrovsk's leading oligarchs, such as Viktor Pinchuk or Ihor Kolomoysky, but given the scale and indiscriminate nature of the explosions, that too seems unlikely.
It seems more likely—and the Ukrainian authorities, at least, have already concluded—that the bombings were acts of terrorism. Some Ukrainians are already suggesting that homegrown terrorists set off the bombs to disrupt the Euro 2012 Soccer championships, scheduled for June (though no matches are planned in Dnepropetrovsk). Ukraine has not previously been the victim of international terrorism, but Dnepropetrovsk, and Ukraine in general, may simply have appeared to opportunistic attackers as a soft target, with relatively lax security and police who could be easily paid off to ignore the warning signs of a plot.
To radicals from outside Europe, the subtle distinctions between EU members like Spain and the U.K. and former Soviet states like Ukraine may not matter much. In fact, on the eve of the Euro 2012 tournament, Ukraine may have seemed like an ideal high profile European target.
If international terrorists were responsible, they might have picked Ukraine for more specific political reasons. From 2003 to 2008, Ukraine had some 1,600 soldiers in Iraq, and it is one of only two post-Soviet countries contributing troops to the NATO mission in Afghanistan, though Ukraine's contingent numbers less than two dozen. Ukraine might also have been a victim due to its close association with Russia, a country on Islamic extremists' list of enemies because of the ongoing Islamist insurgency in the North Caucasus and Russia's staunch support for the al-Assad regime in Syria. Although Ukraine watchers see relations with Moscow as unusually strained right now, Al Qaeda's thinking on this point may be a bit less precise.
On the other hand, conspiracy theories are popular in Ukraine and some may imagine a more direct Russian role in this tragedy, precisely because of the two countries' strained relations. Ukraine has refused to join Russia's customs union with Belarus and Kazakhstan, and has erected barriers to prevent Russia's Gazprom from gaining control of Ukraine's network of transit pipelines. Moreover, although President Yanukovych has taken NATO membership for Ukraine explicitly off the table, he continues to push for EU integration.
Some Russians have argued that the infamous apartment bombings in 1999, on the eve of Putin's elevation to the presidency, were actually orchestrated by Russian security services to drum up public support for the war in Chechnya. If the authorities were capable of such brutality on Russian soil, why not use the same means to pressure and embarrass Ukraine, which might be forced to scale back the upcoming soccer tournament or turn to Russia for help?
On the theme of cynical political motivations, opposition politicians have already begun to lambast the government for failing to prevent the attack, and even to insinuate the involvement of government figures. For the embattled Yanukovych administration, there may actually be a silver lining to this tragedy, if fear and insecurity drive Ukrainians to back the president's Party of Regions in parliamentary elections planned for October.
That the attackers targeted a largely Russian-speaking eastern city that has been a Party of Regions stronghold might also stir up fears about western Ukrainian radical nationalism, as in the 2010 bombing of an orthodox church, and the attacks on World War II veterans by radical nationalists last year. At the very least, the bombings have already displaced this month's previous top story, the failing health of imprisoned opposition leader Yulia Tymoshenko, though neither headline is exactly good news for the government.
The tragedy that has struck Ukraine is a reminder that acts of terror are possible anywhere and at any time. When world leaders call to offer condolences and assistance, they should also remind Ukraine that the most powerful response to terrorism is to deny its desired effect. Despite recent setbacks, Ukraine has made progress toward reforms that will safeguard citizens' personal, economic and political freedom. In the aftermath of this tragedy, Ukraine has an opportunity to show that pursuit of justice, security, and freedom are not mutually exclusive.


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Managing Editor
When one hears what the Saskatchewan community of Fox Valley — with a population of 330 according to the last official census — had done to help, it really is inspiring.
It's exciting times for Jasper Homes' (sister company) Jade Homes, and its ownership by the Hiebert Group. Hiebert Group president John Hiebert and Chris Nickel who is Jasper's Masterbuilder can't be more pleased with a new development in Dunmore.
As humans we are all known to make stupid mistakes and commit major acts of non-intelligence.
The horror stories coming from the Oct. 17 fires which ravaged southern Alberta and southwest Saskatchewan are heartbreaking, even for the hardest of hearts.
The number 13 is usually considered an unlucky number for those who are superstitious or perhaps for any of the unsuspecting and naive characters who are part of the fictitious Friday the 13th movie victims.
There has been a lot of talk recently about the number of shocking and horrifying cases of sexual-related misconduct in Hollywood.
If you're friends with Devon Oman, the creative genius that is Swift Current's own Dead Prairies, and you didn't, he is in the midst of editing his non-profit horror film company's latest project: The B Squad.
Many people may have been caught off guard by Brad Wall's announcement on Facebook he would be stepping down as premier. After sober second thought, it may not be as surprising as it seems.
Mental health is no longer that phony, make-believe issue that critics used to chastise as a reason for people "having issues" or serious personality or behavioral flaws.
It could be called a blessing in disguise.


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With daily flights from many cities across North America, getting here is easier than you would imagine. Click below to see which flights are closest to you.
Get inspired for your trip.
Discover the past culture that still thrives today.
Explore our protected nature preserves.
Underwater adventures are everywhere, down here.
Book the perfect vacation with a Belize Specialist


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When you're making changes in your family's lifestyle that may involve everything from what you put on the dining room table to how often you allow the TV set to be turned on, don't be surprised if your preschooler and siblings are annoyed (or worse) at times.
If you're going to help your youngster manage her weight, you can expect some groaning and complaining and even some outbursts of anger. Whenever you make changes like whether there are fewer trips to fast-food restaurants or more physical activities for the entire family, there will probably be some grumbling. If you're not careful, you might be tempted to give in to this anger by letting your child have a doughnut or turning the TV back on. But that approach will undermine your other efforts to get her weight under control.
To reduce the likelihood that your child will react with anger, make sure that the changes you're making are applied to your entire family. If you serve your overweight child different foods than others at the dining room table, she'll feel singled out and isolated. If everyone is eating a healthy dish of fruit as a dessert, however, she's much more likely to accept it as the new way of doing things.
When angry outbursts do occur, it's good to already have a plan in place to deal with them effectively. Talk with the other adults in the home and agree in advance on how you all will respond to these temper tantrums about your family's lifestyle changes. Here are some suggestions.


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You can read Human Kinetics e-books on desktop, laptop, and various mobile devices, as long as you have authorized the device or e-reader app to read e-books protected by Adobe's digital rights management (DRM).
Format available: PDF
Reference for public health professionals, health promotion specialists, exercise physiologists, and fitness professionals who design, implement, and evaluate physical activity interventions. Also a resource for recreation and community centers and a supplemental text for physical education and health promotion curricula.
Lynda B. Ransdell, PhD, is a professor in the department of kinesiology at Boise State University.
Ransdell has dedicated her career and research to helping sedentary people increase their levels of physical activity. Ransdell has designed, implemented, and evaluated numerous physical activity interventions and has worked as a consultant to help others develop interventions in community settings.
Known for her research of physical activity patterns of women, Ransdell has conducted two well-respected studies, Daughters and Mothers Exercising Together (DAMET) and Generations Exercising Together to Improve Fitness (GET FIT), which detail some of the only family-based interventions known to be successful in increasing physical activity in typically inactive women.
Ransdell has published over 60 peer-reviewed articles and 14 book chapters, mostly related to increasing physical activity in sedentary individuals. She is also the author of Ensuring the Health of Active and Athletic Girls and Women, a popular text for courses examining the physiological and psychological implications of sport and physical activity participation for girls and women.
She is a fellow of the American College of Sports Medicine (ACSM) and the Research Consortium of the American Alliance for Health, Physical Education, Recreation and Dance. Ransdell has also served as president of the National Association for Girls and Women in Sport, editor of the Women in Sport and Physical Activity Journal, and coeditor of Physical Activity Today. She is the recipient of the ACSM Visiting Scholar award from University of South Carolina (1998) and Outstanding Alumni awards from Arizona State University and Eastern Kentucky University.
Ransdell resides in Boise, Idaho, where she enjoys participating in ice hockey, cross-country skiing, running, and mountain biking.
Mary K. Dinger, PhD, is a professor in the department of health and exercise science at the University of Oklahoma at Norman, where her teaching and research focus on promoting physical activity.
Working in a research, consulting, or community service capacity, Dinger has designed, implemented, and evaluated several physical activity interventions. She has published her research in more than 50 articles in peer-reviewed journals.
Dinger is a fellow of both the American College of Sports Medicine (ACSM) and the Research Consortium of the American Alliance for Health, Physical Education, Recreation and Dance (AAHPERD). She currently serves as epidemiology section editor for Research Quarterly for Exercise and Sport and on the editorial board of the American Journal of Health Behavior. She was previously an editorial board member of the American Journal of Health Education and an executive board member of the American Academy of Health Behavior and the Research Consortium of AAHPERD.
Dinger resides in Norman, Oklahoma. She enjoys staying physically active by playing with her daughter, biking, and hiking.
Jennifer Huberty, PhD, is an assistant professor in the department of health, physical education, and recreation at the University of Nebraska at Omaha, where she manages the graduate curriculum for physical activity in health promotion.
Huberty has designed, implemented, and evaluated numerous research- and community-based physical activity interventions. She is the creator of Women Bound to Be Active, a physical activity book club aimed at increasing the number of women who maintain healthy physical activity behaviors. This nine-month intervention provides women with the skills and tools for initiating and maintaining a physically active lifestyle. The rationale for this program and details on its feasibility have been published in Research Quarterly and Women and Health.
Based on research gathered in Women Bound to Be Active, Huberty also created a locally implemented weight management program, Fit for Life, which provides a no-cost opportunity for underserved people to learn healthy behaviors and be active within their communities. Huberty directs the physical activity component for Club Possible, a physical activity and nutrition education afterschool program focusing on prevention of childhood obesity. The program has been implemented in 18 afterschool agencies, including CampFire USA, YMCA, Boys and Girls Club, and Girl Scouts.
Huberty is a member of the Society of Behavioral Medicine and the American Alliance for Health, Physical Education, Recreation and Dance. For outstanding research and community service, Huberty was awarded the Varner Professorship for 2007. In 1999, she received a graduate student research award from the Southern Academy for Women in Physical Activity, Sport, and Health.
Huberty resides in LaVista, Nebraska, with her husband, Rodger. She enjoys Spinning, running, weight training, and scrapbooking in her free time.
Kim H. Miller, PhD, is an associate professor of health promotion in the department of kinesiology and health promotion at the University of Kentucky at Lexington, where she works with undergraduate and graduate students to design and implement health promotion interventions.
Miller received her doctorate in health education from Southern Illinois University in 2000. For over eight years, she has conducted research in the area of health and physical activity, publishing numerous research papers and presenting her findings at international conferences. Miller has also served as a consultant in designing physical activity and health promotion interventions for employee wellness programs in a variety of settings. She is a member of the American Academy of Health Behavior and the American Association for Health Education.
In her free time, she enjoys running, hiking, reading, and cooking. Miller resides in Lexington, Kentucky.
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The "Blessed" John Henry Cardinal Newman was beatified by Pope Benedict XVI at Cofton Park, Birmingham on 19 September 2010. This was the culmination of the Holy Father's visit to the UK. The miracle required for Cardinal Newman's beatification was officially recognised by the Holy See on 3 July 2009. In our Cardinal Newman section, you can read his biography, look at key teachings and reflect on Deacon Jack Sullivan's miracle cure from a serious spinal disorder.
Clifton Diocese has produced a series of excellent podcasts on Cardinal Newman.
Father Peter Cornwell, Newman scholar and Clifton priest, introduces us to the man Pope Benedict XVI's coming to England to beatify - helping us get to know the great Englishman whose ministry touched so many people.
This section of the website provides extracts from Newman's work on a variety of topics, including: The Catholic Church, The Pope, Education, Christian Praye... Read more
This section of the website provides information on the process of beatification, the cause for the beatification of Cardinal Newman, and Deacon Jack Sulliva... Read more
This section of the website provides information on Cardinal Newman, including a timeline, biographies and an article looking at the significance of Cardinal... Read more


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November 23. 2013 9:14PM
Ted Siefer's City Hall: Hold your horses, Tex; just how weird was it?
By TED SIEFER
New Hampshire Union Leader
Maybe it was because the aldermen felt less restrained in their first meeting since the election; maybe it was the lingering effects of Sunday's full moon. In any case, there was a weird energy at Tuesday's meeting of the Board of Mayor and Aldermen, starting with the guy in the cowboy hat who delivered a rambling monologue during the public comment period and several outbursts throughout the night.
The topic that seemed to dominate the evening, both the full board meeting and an earlier meeting of the Committee on Accounts, was itself kind of weird: the dog park. What started with complaints from a handful of disgruntled former park users about Manchester Dog Park Association (MDPA) has escalated into the latest feud involving Alderman-At-Large
Joe Kelly Levasseur
The dog park, of course, is largely the work of Ward 10 Alderman
Phil Greazzo
. Levasseur entered the fray by suggesting at the previous aldermen's meeting that the MDPA had let its liability insurance lapse, the key component of the agreement it had entered into with the city to use the land for the park.
The move has clearly lit a fire under Greazzo and he sought to throw the book at Levasseur, a Republican.
At Tuesday's meeting, Greazzo made his case that Levasseur should be referred to the conduct board, arguing that by obtaining the insurance information and gabbing about it at the previous meeting, he had violated a section of the charter concerning the disclosure of confidential information.
But the other aldermen would have no part in it. Greazzo couldn't even get a second for his motion.
"My position is that sending someone to the conduct board is very serious," said Ward 1 Alderman
Joyce Craig
. "To me, this is a 'he-said-she-said' situation."
This was essentially the view proffered by
Peter Chiesa
, a lawyer in the city solicitor's department. By way of disclosure, Chiesa also mentioned that he had once represented Levasseur in an unspecified "civil matter."
But Greazzo wasn't ready to let the issue lie. Later in the evening, acting on the suggestion of Ward 3 Alderman Pat Long, he invoked another section of the charter, 8.15, under which any alleged violation of the legal code "shall be referred to the mayor, who shall review the allegation with the official or officials involved."
And this request didn't require a vote of the aldermen.
The move essentially dropped the matter into the lap of Mayor
Ted Gatsas
, a man with whom Levasseur has had his share of quarrels of late.
Levasseur has indicated that he's not interested in participating in such a tribunal. "I'm not about to go into a hostile office, with a hostile mayor that did everything in his power to make sure I did not win reelection, and discuss anything that he can twist to his own political benefit and become a he said, she said ordeal," he said in an email.
And Greazzo has since made it clear that he intends to raise a laundry list of allegations against Levasseur, including that he lied to building inspectors and misrepresented an incident in which he accused a Manchester police officer of intimidating him.
Greazzo also noted that if Levasseur doesn't agree to meet with the mayor, "his refusal constitutes another violation" of the charter.
Gatsas has given no indication of how he'll proceed.
The charter states that if the mayor's review does not resolve the matter, it shall be referred to the city's chief legal officer, who in turn must make a report to the aldermen within 90 days. But speaking to the whole fracas over the dog park, Gatsas had some supportive words for Greazzo.
"I want to say you're someone who was very dogged in getting the dog park," he said at Tuesday's meeting. "We should thank you and commend you for it. You took money out of your pocket and did what you said you were going to do. . I know people in Manchester thank you, and I know the dogs thank you."
- - - - - -
So was there any legitimacy to the claims that the MDPA's insurance had lapsed? It doesn't look like it. This was the lukewarm conclusion of Deputy City Solicitor
Tom Arnold
at the Accounts Committee meeting earlier in the day. Greazzo had furnished documents indicating that the MDPA had been covered since before the dog park opened.
Still, Ward 12 Alderman
Patrick Arnold
wanted there to be a more thorough review, and the aldermen later passed a motion to this effect.
Arnold said he appreciated Greazzo's "candor" on the issue, but he wanted the review to put any concerns to rest.
"It seems we've spent more time on this item than a lot of other issues," he said.
- - - - - - -
Continuing the theme of novel occurrences, Tuesday's meeting also saw Welfare Commissioner
Paul Martineau
come hat in hand to the aldermen. He was projecting a $270,000 deficit for the year because of increased demand for emergency shelter, burials and other assistance. Martineau, as you may know, has made the savings he's brought to the department and his rigorous review process a central plank in his many campaigns for office, including the one he just won.
There won't be any adjustments to at least one line in the welfare budget: Martineau's $114,000 salary. The aldermen, by the narrowest of margins, rejected a motion from Levasseur to set the commissioner's salary at $80,000. The welfare commissioner post is an outlier in city government, it being the only elected position subject to annual steps and COLAs under the Yarger Decker system. Levasseur's proposal would have given the post a set salary like that for the mayor who gets a flat $68,000.
Gatsas said he believed the change would prompt Martineau to step down immediately to lock in his pension rate, and that would force the city to hold a special election.
But the city clerk said such a vacancy would be filled by the aldermen, not an election.
All the better, Levasseur said: Leaving the seat unfilled would go a long way toward plugging the budget hole.
In the end, Martineau avoided a haircut, but only by a hair. The vote was 6-6, with two abstentions.
Would Martineau have retired if the aldermen had passed the measure? He never returned a call last week.
But he did make his views known during the meeting about the prospect of a $34,000 pay cut.
"No, I'm not OK with that," he said. "When I took over the position, I also got on Yarger Decker. I just want to be treated like any other."
Ted Siefer may be reached at email@example.com. Follow him on Twitter @tbsreporter.


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Smashing Pumpkins' Billy Corgan 'Disappointed in America'
Billy Corgan's war of words against, oh, pretty much everything continues. This time, while appearing last week (June 29) on CNN's 'Piers Morgan Tonight,' the Smashing Pumpkins' auteur set his sights on the American public, according to the Hollywood Reporter.
"I'm very disappointed in my country right now because I think we've lost our moral compass," Corgan said. "At some point, we have to get out of this paternalistic churn we're in where we want Daddy to come save us and the banks to come and save us. We need to get back to a level of social responsibility that we haven't seen for a long time."
"I don't see the vigorous democracy that I was raised to believe in, and I don't understand where that went," he continued, while stating that President Obama "ran on a moral compass agenda, but what happened?"
Corgan has been getting as much publicity for his opinions as his music as he promotes Smashing Pumpkins' new album, 'Oceania.' His own strong moral compass allowed him to recently claim that nearly all the bands that he came up with are either "lazy or they're scared." He also slammed his ex-bandmates and said that he wanted to "piss on f—ing Radiohead" for what he perceives as their "pomposity."
Despite all his rage, 'Oceania,' debuted at No. 4 on the Billboard 200.


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MACON, Ga. (May 1, 2006) - For the second time in as many weeks, a member of the ETSU softball team has claimed Atlantic Sun Player of the Week honors, with junior Stephanie Gaynord (Manassas, Va.) picking up her first conference accolades of the season on Monday. Gaynord helped the Lady Bucs to a 3-1 week, hitting .500 for the week, including a trio of homeruns.
The junior shortstop went 7-for-14 over four games, with five runs batted in and five runs scored. Presently on a five-game hit streak, Gaynord recorded base knocks in each of the week's four games, including two-hit efforts in three contests. In the field, Gaynord committed only one error for the week, while posting seven putouts and 18 assists.
Gaynord currently leads the team in batting average (.304), runs scored (40), hits (49), doubles (12), and homeruns (8).
The Lady Bucs are currently amid a late-season hot streak, winning five of its last six, including A-Sun sweeps over Stetson and Belmont. Sophomore Amanda Haverman (Kirkwood, Mo.) garnered A-Sun Player of the Week honors on April 24, after playing a starring role in the Lady Bucs' upset of the league-leading Hatters.
ETSU, which is still in the running for a spot in the A-Sun Tournament, plays its final series of the season on Friday, traveling to Lipscomb for a two-game tilt. Game time is scheduled for 2 p.m. CST in Nashville, Tenn.


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I don't seem to find the time often, but recently I was able to fit in another visit to the ONETUG meeting. They've got a great venue, a large meeting room at Orlando City Hall, the only downside is finding your way to it the first time and finding parking (about $5 in the garage across the street). Standard pizza for food courtesy of Tews, good enough. Attendance was 30-35, a good showing. Their meeting runs from 7-9 pm compared to 6-8 pm for our SQL group, I like the later start but not the later ending. No good answer to that.
One new thing they are trying is a book swap/library, have users bring in some books and do some swapping, save some money on the Amazon bill. Not sure how it scales or if it will work, but seems like the perfect kind of thing for a user community. They are already starting to get ready for the next Orlando Code Camp scheduled for Mar/April next year, and that's really good news. Jessica Sterner just took over as President from Shawn Weisfeld in July, and while she was pretty involved in the earlier Code Camps, planning some extra time will cushion the lessons yet to be learned (there are always lessons!).
Featured speaker was Joe Healy of Microsoft talking about the new features added in Visual Studio SP1. I'm not a huge fan of adding features with service packs, but I get that the world is moving faster for better or worse. Decent presentation without only minimal marketing fluff, and he did a nice job of conveying his enthusiam about the value that the new features add. You can download the presentation deck from http://www.devfish.net/downloads.aspx. Also got a nice plug from Joe about the upcoming SQLSaturday #8 in Orlando during the presentation. One piece I had not seen before was about ASP.Net Routing - looks like URL rewriting plus, will have to read more on it.
We adjourned about 9 pm and made it to the after social bar by about 9:30, about 10 attending, light discussion about upcoming events in Florida but nothing too exciting.


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Fifteen Alzheimer patients were treated with increasing doses of vinpocetine
(30, 45, and 60 mg per day) in an open-label pilot trial during a one-year
period (Thal 1989). The study was done at VA Medical Center, in San Diego,
California. Vinpocetine failed to improve cognition at any dose tested. There
were no significant side effects from the therapy.
In a double blind clinical trial, vinpocetine was shown to offer significant
improvement in elderly patients with chronic cerebral dysfunction (Balestreri
1987). Forty-two patients received 10 mg vinpocetine three times a day for
thirty days, then 5 mg three times a day for sixty days. Matching placebo
tablets were given to another forty patients for the ninety-day trial period.
Patients on vinpocetine scored consistently better in all cognitive
evaluations. No serious side effects were reported.
Twelve healthy female volunteers received pre-treatments with vinpocetine 40
mg three times a day or placebo for two days according to a randomized,
double-blind crossover design (Subhan 1985). On the third day of treatment
and one hour following morning dosage, subjects completed a battery of
psychological tests. Memory was significantly improved following treatment
with vinpocetine when compared to placebo.
Vinpocetine is sold in 5 and 10 mg pills. Levels peak in the bloodstream
within an hour and a half after ingestion.
The Experience of Users
Dennis, a 72 year-old patient with age related cognitive decline says, "I
take 5 mg of vinpocetine at breakfast and lunch. I feel more focused and it
seems that I can make decisions quicker. I also notice colors to be more
vivid.." Other patients report similar positive effects.
Dr. Polimeni, a doctor in Rome, Italy, says, "Vinpocetine is a good cognitive
enhancer. It improves visual and auditory perception similar to pregnenolone.
My patients appreciate the effects better after a few days of therapy."
The Author's Experience
I like the effects from vinpocetine. On 10 mg, I notice improvement in
concentration and focus and enhancement of color perception peaking at about
two hours after dosing. Thereafter, the effects gradually decrease but
persist for a few hours. I do not notice any significant changes in mood or
energy levels.
Vinpocetine appears to be beneficial in cognitive disorders that are due to
poor blood flow to the brain. Therefore, individuals with atherosclerotic
vascular disease are probably the most likely to benefit from vinpocetine.
Until long-term studies are available, regular intake for prolonged periods
should be limited to 2.5 or 5 mg once or twice daily.