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Franconia Notch State ParkApril 21. 2011 3:38PM
Located in the heart of the popular White Mountain National Forest. Franconia Notch is a spectacular mountain pass traversed by a unique parkway which extends from the Flume Gorge at the south to Echo Lake at the north. For eight miles, I-93 winds between the high peaks of the Kinsman and Franconia mountain ranges.
Franconia Notch was the home of the famous Old Man of the Mountain, the same "Great Stone Face" immortalized by Nathaniel Hawthorne and Daniel Webster.
While you are here, stop at the Flume Gorge Visitor Center and walk through the renowned Flume Gorge, ride the exciting aerial tramway at Cannon Mountain, and visit the New England Ski Museum. Take your time, stop for a swim at Echo Lake, net a trout while fly fishing at Profile Lake, ride your bike on the Recreational Trail, watch for rock climbers, hawks, and falcons on Cannon Cliffs, or hike on the Appalachian Trail. Bring the family, stay awhile, and enjoy Franconia Notch State Park.
Activities: Camping, swimming, hiking, picnicking, fishing, boating, biking, skiing/snowboarding, cross country skiing, snowmobiling.
The Basin
The beautiful waterfall at the Basin, has at its base, a granite pothole 20 feet in diameter. It is believed to have been eroded 15,000 years ago while the North American ice sheet was melting. It has been smoothed by small stones and sand whirled around by the Pemigewasset River. Below the Basin is a water-eroded rock formation called the Old Man's foot.
Cannon Mountain
Cannon's 80-passenger aerial tramway quickly ascends 2,022' over a horizontal distance of more than a mile whisking you above the timberline to the 4,200-foot summit for spectacular views of the White Mountains, into Maine, Vermont and even Canada. Walking trails leave from the summit station to an observation tower with panoramic views of the valleys and mountains. Cafeterias and The New England Ski Museum.
Echo Lake Beach & Cannon Mountain RV Park
Beautiful Echo Lake, at an elevation of 1,931 feet, offers swimming, fishing, and small boat access, as well as views of Mt. Lafayette and Cannon Mountain. In a different watershed from Profile Lake, its waters flow westerly toward the Connecticut River.
Flume Gorge
A natural chasm takes visitors from the Flume Visitor Center on wide gravel paths and wooden walkways through covered bridges, past waterfalls and through the 800-foot long gorge with its sheer 90-foot walls. Scenic pools, glacial boulders, and mountain views. Free 15-minute movie at the Information Center provides an introduction to Franconia Notch State Park.
Lafayette Campground
98 sites, showers. Camp store. Excellent hiking, biking base with easy access to Appalachian Trail and nine-mile paved bike path.
Old Man of the Mountain
Also known as "The Profile" or the "Great Stone Face," an internationally known phenomenon, the Old Man was discovered in 1805 by workmen building the first road through Franconia Notch. The Old Man, which collapsed in May of 2003, was a natural, granite profile jutting from a sheer cliff 1,200 above Profile Lake. Carved by nature thousands of years ago, the profile was formed by five separate ledges and measured 40 feet from chin to forehead. For more information, go to the Old Man of the Mountain page.
Profile Lake
This small, clear body of water is the headwaters of the Pemigewasset River. Directly below where the Old Man of the Mountain was, it was often called the Old Man's Washbowl. The lake is well-known for its brook trout and is open to fly-fishing only. In the 19th Century Profile Lake was the entertainment center of the region, housing concerts and other events throughout each summer as New England society flocked to the White Mountains.
Boise Rock
In the early 1800s, Thomas Boise sought shelter under this large boulder when a blizzard blocked passage for him and his horse on the notch road. Near the boulder you can find a cool spring, picnic tables, and an exceptional view of Cannon Cliffs. Boise Rock is only accessible from the northbound side of the highway.
Hiking in Franconia Notch State Park
Briefly described below are a few of the more popular family hikes in Franconia Notch State Park.
- Bald Mountain and Artists Bluff, reached by a short hike, offer fine views of Cannon Mountain and Franconia Notch. The 1 1/2 mile loop begins in the parking area across Route 18 from Peabody Base Lodge. After 1/4 mile a short, steep path diverges left for 1/10 mile to the open summit of Bald Mountain. The main trail continues on from the junction and bears right, up and across the low ridge. A short, unmarked path diverges left to the open top of Artists Bluff. The main trail continues down to Route 18 near Echo Lake.
- Lonesome Lake, nestled in the mountains 1,000 feet above the floor of the notch, is a popular hiking destination. It is reached by a 1 1/2 mile (one way) trail that begins at Lafayette Place, just south of the cabin near the campground. A lakeside trail leads to the Appalachian Mountain Club (AMC) hut at the far end of the lake and passes by an inactive beaver lodge.
- Kinsman Falls, a beautiful, secluded and oft overlooked spot on Cascade Brook can be found by following the Basin-Cascades Trail for 1/2 mile from the Basin. Many potholes and ledges in the brook along the way make for an enjoyable twenty minute (one way) walk. A rough path diverges left off the trail to the cool base of the falls. Follow the main trail a short way to a brook crossing to the left that leads to Rocky Glenn Falls.
- The open ledges at the 2,557-foot summit of Mt. Pemigewasset (Indian Head) afford excellent views of Franconia Notch, the Franconia Range and the valley to the south. The 1.4 mile (one way) trail climbs moderately to the summit from the Flume Visitor Center parking area. Return can be made by the same route or via the Indian Head Trail that diverges from the Mt. Pemigewasset Trail just below the summit, and leads one mile to Route 3, one mile south of the Flume Visitor Center.
Location: On I-93/Route 3, Franconia Notch Parkway, Lincoln/Franconia
General Information: 603-823-8800
Flume Gorge & Visitor Center: 603-745-8391
Lafayette Campground: 603-823-9513
Cannon Mountain, Echo Lake Beach, Cannon RV Park: 603-823-8800
Amenities: Campground, RV campground, restrooms, cafeterias, gift shops, 8-mile paved recreation path, canoe, paddle boat and bike rentals, boat launch, covered bridges, hiker information center, New England Ski Museum, full service ski area
Operation Schedule:
Franconia Notch in General: Year-round
The Flume Gorge & Visitor Center: Early May to Late October
Cannon Mountain Aerial Tramway: Summer: Mid-May to Mid-October
Winter (skiing/snowboarding): Late November to Mid-April
Lafayette Campground: Mid-May to Columbus Day
Cannon Mountain RV Park: Year-round
NH State Parks Website
NH State Parks Pet Policy
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Nothing funny about this
Joe Knoedler (02-22-12) takes up argument against the premise that liberalism is turning young people's minds to mush. At Prince George's Community College in Maryland, President Obama told students "...every time prices start to go up...politicians dust off their 3-point plans for $2.00 gas." (Laughter) "Been the same script for 30 years. It's like a bad rerun." (Laughter) While laughing at his jokes, students weren't thinking about the long-standing practice of stifling energy production as a root cause for many of our economic problems. The comedian in chief certainly won't enlighten them. I see no humor in it whatsoever.
He told them that drilling advocates say "...if we just drilled more for oil then gas prices would immediately come down..." Truthfully, advocates believe pursuing a more aggressive energy policy and cutting federal regulations 30 years ago would have brought about lower, more stable fuel prices long before now. Perhaps far fewer manufacturing companies would have left the country. Obama's effort (alchemy) is turning borrowed money into failed "green energy" companies and Democrat campaign funds. We have lost billion$. Tell students that joke.
He repeated his diatribe that we have only 2% of the world's known oil reserves. This misleading figure doesn't include resources roped off by the government. According to industry experts, the U.S. has more than 1.4 trillion barrels of technically recoverable oil—enough to meet all U.S. needs for the next 200 years, without imports. Obama said, "Under my administration, America is producing more oil today than at any time in the last eight years." (Applause) This may be happening during his administration, but it is not because of anything he has done. The Bush blamer is taking credit for production on public lands (he couldn't stop) that was already approved by the previous administration. Drilling is occurring on private and state lands, in spite of Obama's moratoriums.
His administration claims that oil and gas leases on public land increased 20% in 2011. Leases issued in 2010 were at the lowest level since the Bureau of Land Management began publishing the data. A 20% increase from there is meaningless. Taxpayers collected 258 times less revenue ($9.4 billion) from off-shore lease sales in 2011 than the last year of the Bush administration. He joked, if Republican presidential candidates "...were around when Columbus set sail (laughter) they must have been founding members of the Flat Earth Society." (Laughter) The irony is, if his anti-energy policies and military budget cuts are allowed to continue, our navy will be the Nina, the Pinta and the Santa Maria.
Obama told students there is no "quick fix" for high gas prices, he is "drilling at a record pace" and his opponents are against alternative energy sources. Students (and adults) laughed throughout the speech and applauded at the end. They most likely left there accepting what the snake oil salesman said as fact, not bothering to research the truth on their own. Is that Mensa, or is it mush? You decide.
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Garmin GPS computers are one of the best available. With user-friendly interfaces and ergonomic buttons and outer casings, Garmin's GPS computers are a step above the competition. Here at ProBikeKit USA, we offer a wide selection of GPS units, suitable for running, cycling and triathlon. Read below to see the main features of a GPS computer.
One of the most standard features of all of Garmin's GPS computers is the heart rate monitor, a really useful tool that has quickly become an essential in the endurance training and sports world. If you don't use one, then adding this tool into your training can be really insightful and useful to help you measure your runs and rides, helping you to improve energy conservation, pacing and overall efficiency.
It goes without saying that GPS computers come with GPS, but what are the real benefits of being able to track yourself mile by mile? Firstly, you can see how long it took you do complete 10 miles over a 100 mile bike ride, or examine how fast you're running a mile in your triathlon training runs. Using this as 'live data', you can monitor your pace as you run/ride, and make changes there and then to conserve energy and improve overall performance. Back at home, you can download the data straight to your computer and look back over it to analyse where your strengths and weaknesses lie, pinpointing exactly where you were when you took a turn for the worse!
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Crash Kills One and Injures Well-Known Bangor Orthodontist and His Wife
A fatal crash remains under investigation after one woman was killed and three others were hurt.
The crash happened yesterday afternoon on Route 16 in Embden.
The Somerset County Sheriff's department says the victim as 22-year-old Jennifer Nile of Embden, a passenger in one of the vehicles involved in the crash.
Nile was in a car driven by 24-year-old Mark Schobel of North Anson, who tried to pass another eastbound vehicle, and collided with a westbound car driven by 67-year-old Leon Souweine of Bangor.
Nile was pronounced dead at the scene. Schobel, Souweine and his passenger, his wife Ruth, all required hospitalization.
Souweine, who is a well-known orthodontist in the Bangor area and a member of the rock band, Retrorockerz, was treated and released from Redington-Fairview Hospital in Skowhegan and his wife Ruth was transported to EMMC via life flight. EMMC is releasing no information on her condition.
There's no immediate word on Schobel's condition.
The crash remains under investigation but police say speed appears to be a factor.


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Saints Fall To Panthers, 17-13
For the second-consecutive week, the New Orleans Saints failed to lock up an NFL playoff berth, after falling to the Carolina Panthers, 17-13, at Bank of America Stadium in Charlotte, North Carolina on Sunday.
The win by Carolina gives them a one-game lead over New Orleans in the NFC South with one week to play in the 2013 NFL season.
The Saints can still win the division, but they would have to defeat the Tampa Bay Buccaneers in their season finale next Sunday, and hope for an upset win by the Atlanta Falcons over the Panthers.
New Orleans can clinch a wild-card entry with a win next week, or a loss by the Arizona Cardinals to the San Francisco 49ers.
The Saints would miss the playoffs entirely, if they would lose to the Bucs next Sunday, and the Cardinals would win over the 49ers.
In Sunday's game, the Saints took a 6-0 lead on two Shayne Graham second quarter field goals, from 40 and 24 yards away, before the Panthers grabbed the lead before halftime, on a 43-yard touchdown run by DeAngelo Williams.
Carolina scored the only points of the third quarter, on a Graham Gano 40-yard field goal, extending their lead to 10-6.
The Saints grabbed the lead at the 6:37 mark of the fourth quarter, when Drew Brees connected with Jimmy Graham on a 5-yard touchdown pass, giving them a 13-10 advantage.
It was the Panthers who would strike last however, when quarterback Cam Newton threw a 14-yard touchdown pass to Domenik Hixon with 23 seconds left, lifting them to the four-point win, before more than 70,000 rain-drenched fans.
New Orleans actually out-gained Carolina, in terms of total yards, 366-222, and also led in time of possession, 38:48/21:12, but suffered from two Brees interceptions, and from their inability to put the football in the end zone early in the game.
Brees finished the game completing 30-of-44 passes for 281 yards, along with one touchdown and two interceptions, while Mark Ingram carried the ball 13 times for 83 yards.
Meanwhile, Carolina was led by Newton, who completed 13-of-22 passes, for 181 yards, with a touchdown and an interception.
With the win, the Panthers, who can clinch the number two seed, and a first-round playoff bye with a win next week, improved to 11-4, while the Saints, who have now lost three of their last four games, dropped to 10-5.
New Orleans, who is still undefeated at home, at 7-0, finished their regular season with a road record of 3-5.


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Lithonia Georgia Loan Interest Rate
Take a few moments to browse Lithonia, GA loan interest rate options. It's a smart idea to compare all available schools in your target area, as well as consider taking some of your elective courses online. Check with each business school below for assistance with loan management certificate program requirements, degree prerequisites, and class registration. You may request Lithonia, Georgia loan interest rate information from several different schools below, without making a commitment.
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The US Small Business Administration (SBA) provides emergency loans to businesses, based on specific financial criteria of the business and its principals. The key factors of small business loan eligibility are based on how the business generates taxable income, the incorporation structure, and business location. The SBA outlines universal loan application requirements. To be eligible for financial assistance, businesses must operate for profit, conduct business in the US or its possessions, and make use of alternative financial resources, including personal assets, before seeking government loan assistance.
In fact, the business cannot have incurred a prior loss related to the current business debt. Special considerations may apply to some types of proprietorships and small businesses. Franchises, for example, are eligible except when a franchiser retains power to control business operations. An eligible company must use SBA loan proceeds to acquire (or lease) real property and must not make excess profit from outside its normal business activities. Beyond degree major requirements, you may consider Henderson Community College final exam schedule as a complementary elective.


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Serve this classic side dish with a crisp, mixed green salad and cooked lean meat, poultry or fish.
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Assemble recipe as directed. Refrigerate up to 24 hours. When ready to serve, bake (uncovered) in 350°F oven 45 to 50 min. or until heated through, topping with reserved onions for the last 5 min.
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Beaumont/Port Arthur
Early Friday morning, a Jefferson County Sheriff's Office deputy arrested two motorists for possession of two kilograms of cocaine.
Friday, Sept. 21, at about 4:18 a.m., the Jefferson County Sheriff's Office stopped a vehicle for a traffic violation at the 846 Mile Marker on Interstate 10. Both occupants of the vehicle appeared to be very nervous. The deputy asked for consent to search and was given consent by the individual that had rented the vehicle to search the vehicle. The deputy located two kilos of cocaine inside the passenger area of the vehicle.
While we harbor no disrespect for the Wall Street Journal who called us "that scrappy little paper from Southeast Texas," we prefer to think of ourselves as simple seekers of the truth. We're of the opinion that headlines and sound bites never tell the whole story. Our readers demand all the facts, facets and flavors of every story or event. And, they expect to be informed, educated and stirred to action.
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N-acetyl CysteineMay 2010
N-acetyl cysteine N-acetyl cysteine inhibits exercise-induced lymphocyte apoptotic protein alterations.
PURPOSE: To investigate the effect of strenuous exercise and antioxidant administration on pro- and antiapoptotic protein expression in intestinal lymphocytes. METHODS: Female C57BL/6 mice (N = 52) were randomly assigned to receive N-acetyl cysteine (NAC; 1 g.kg(-1)) or saline (SAL) 30 min before treadmill exercise (EX) for 90 min and 2 degrees slope (30 min at 22 m.min(-1), 30 min at 25 m.min(-1), and 30 min at 28 m.min(-1)) and sacrificed immediately (Imm) or 24 h (24 h) after exercise. Control mice were exposed to treadmill noise and vibration without running (nonexercised). Intestinal lymphocytes (IL) were isolated and pro- and antiapoptotic protein expression was evaluated by Western blot analysis. RESULTS: IL protein levels of proapoptotic (caspase 3 and cytosolic cytochrome c) and antiapoptotic (Bcl-2) were significantly different among groups. Relative to nonexercised mice, protein levels of caspase 3 (P < 0.001) and cytosolic cytochrome c (P < 0.005) were significantly elevated, whereas Bcl-2 (P < 0.05) was significantly lower immediately after exercise in mice receiving saline (EX + SAL + Imm) but not in animals receiving NAC (EX + NAC + Imm) or both 24 h postgroups (EX + SAL + 24 h and EX + NAC + 24 h). CONCLUSION: These results suggest that oxidative stress acting through a mitochondrial pathway may play a role in intestinal lymphocyte apoptosis after strenuous exercise.
Med Sci Sports Exerc. 2005 Jan;37(1):53-6
Exercise affects tissue lymphocyte apoptosis via redox-sensitive and Fas-dependent signaling pathways.
Intensive and exhaustive exercise induces an activation of blood T-lymphocytes, which seems to be terminated by apoptotic processes in the postexercise period. Here, we report that exercise-induced T-lymphocyte apoptosis is a systemic phenomenon occurring in various lymphoid and nonlymphoid tissues. The apoptosis rate could be related to exercise intensity and type. Although in some tissues, such as the spleen and Peyer's patches, an early start of apoptosis (1-3 h postexercise) could be detected, a delayed apoptosis (24 h postexercise) was observed in lung, bone marrow, and lymph nodes. Further analysis showed a similar apoptosis distribution among lymphocyte subpopulations. We tested whether components of the extrinsic or the intrinsic apoptotic pathways or both were involved in these processes. Elevated levels of lipid peroxidation-product malondialdehyde (MDA), indicating an increased production of reactive oxygen species (ROS), were found after exercise in Peyer's patches, lung, and spleen, but not in lymph nodes. Application of N-acetyl cysteine (NAC) prevented exercise-induced T-cell apoptosis completely in spleen and bone marrow, partially in lung and Peyer's patches, while it was ineffective in lymph nodes. Additionally, exercise addressed the Fas-mediated apoptosis. The percentage of Fas-receptor (Fas+) and Fas-ligand positive (FasL+) lymphocytes was enhanced in Peyer's patches after exercise. Moreover, FasL+ T cells were increased in the lung, while in lymph nodes Fas+ cells were increased. The critical role of Fas signaling in exercise-induced apoptosis was supported by using Fas-deficient MRL/lpr-mice. In Fas-deficient mice, exercise-induced T-lymphocyte apoptosis was prevented in spleen, lung, bone marrow, and lymph nodes, but not in Peyer's patches. These data demonstrate that exercise-induced lymphocyte apoptosis is a transient systemic process with tissue-type specific apoptosis-inducing mechanisms, whose relevance for the adaptive immune competence remains to be shown.
Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1518-27
The molecular basis for oxidative stress-induced insulin resistance.
Reactive oxygen and nitrogen molecules have been typically viewed as the toxic by-products of metabolism. However, accumulating evidence has revealed that reactive species, including hydrogen peroxide, serve as signaling molecules that are involved in the regulation of cellular function. The chronic and/or increased production of these reactive molecules or a reduced capacity for their elimination, termed oxidative stress, can lead to abnormal changes in intracellular signaling and result in chronic inflammation and insulin resistance. Inflammation and oxidative stress have been linked to insulin resistance in vivo. Recent studies have found that this association is not restricted to insulin resistance in type 2 diabetes, but is also evident in obese, nondiabetic individuals, and in those patients with the metabolic syndrome. An increased concentration of reactive molecules triggers the activation of serine/threonine kinase cascades such as c-Jun N-terminal kinase, nuclear factor-kappaB, and others that in turn phosphorylate multiple targets, including the insulin receptor and the insulin receptor substrate (IRS) proteins. Increased serine phosphorylation of IRS reduces its ability to undergo tyrosine phosphorylation and may accelerate the degradation of IRS-1, offering an attractive explanation for the molecular basis of oxidative stress-induced insulin resistance. Consistent with this idea, studies with antioxidants such as vitamin E, alpha-lipoic acid, and N-acetyl cysteine indicate a beneficial impact on insulin sensitivity, and offer the possibility for new treatment approaches for insulin resistance.
Antioxid Redox Signal. 2005 Jul-Aug;7(7-8):1040-52
Aminoacid support in the prevention of diabetes and diabetic complications.
Emerging evidence suggests that amino acids may be potentially important in the prevention of diabetes and diabetes-associated complications. The pathways involved in the pathogenesis of diabetic complications include increased polyol pathway flux, increased advanced glycation end products formation, activation of protein kinase C and oxidative and carbonyl stress. This review will discuss the modulatory effects of amino acids on insulin secretion and their action in concert with insulin as signaling molecules. Evidences for the role of some amino acids in controlling glycemia and glucose-triggered pathological pathways are also included. Individual amino acids, especially the ones bestowed with antioxidant property like N-acetyl cysteine and taurine seem to have beneficial effects by their ability to reduce intracellular oxidative stress generation and glycooxidation. Other amino acids like glycine and lysine may be good candidates for the prevention of glycation. Nutritional intervention with taurine, phenyl alanine or branched chain amino acids can improve insulin sensitivity and post-prandial glucose disposal. Deficiency of one or more amino acids has been observed in diabetes and the beneficial effects of amino acids in some studies are positively correlated with the increase in plasma levels of these amino acids. Inclusion of individual amino acids/mixture, perhaps as a combinational therapy with conventional treatment protocols could be of therapeutic interest.
Curr Protein Pept Sci. 2009 Feb;10(1):8-17
Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats.
OBJECTIVES: Methylglyoxal, a metabolite of the glycolysis pathway, may play an important role in the development of diabetes and hypertension, but the exact mechanism has not been fully elucidated. The present study was designed to investigate whether methylglyoxal could directly induce insulin resistance and salt sensitivity in Sprague-Dawley rats. METHODS: Rats were allocated to four groups: control (normal drinking water), 1% methylglyoxal in drinking water, 1% methylglyoxal plus N-acetyl cysteine (NAC) (800 mg/kg per day), a methylglyoxal scavenger, or TM2002 (100 mg/kg per day), an advanced glycation endproducts (AGEs) inhibitor. After 4-week treatment insulin resistance was evaluated by an euglycemic hyperinsulinemic glucose clamp technique. In another set of rats, either a high-salt diet (4%) alone, standard rat chow with 1% methylglyoxal in drinking water or high-salt diet plus methylglyoxal was given for 4 weeks. Immunohistochemistry was performed to measure nitrotyrosine and methylglyoxal-induced AGEs, N-carboxyethyl-lysine (CEL) in the kidney. RESULTS: Four-week treatment with NAC or TM2002 completely improved methylglyoxal-induced insulin resistance. Co-administration of methylglyoxal and high-salt diet significantly increased systolic blood pressure, urinary albumin excretion, urinary thiobarbituric acid-reactive substances excretion and the renal nitrotyrosine expression in the kidney (markers of oxidative stress) compared with methylglyoxal or high-salt diet alone. Renal CEL was significantly increased in methylglyoxal-treated rats compared with nonmethylglyoxal-treated rats. CONCLUSION: These results indicate that methylglyoxal-induced insulin resistance and salt sensitivity at least in part by increasing oxidative stress and/or AGEs formation in Sprague-Dawley rats. The present study provides further evidence for methylglyoxal as one of the causative factors in the pathogenesis of insulin resistance and salt-sensitive hypertension.
J Hypertens. 2009 Aug;27(8):1664-71
Chronic N-acetyl cysteine prevents fructose-induced insulin resistance and hypertension in rats.
We examined if administration of an antioxidant compound protects against the development of insulin resistance and hypertension. Male rats were assigned randomly into four groups, and treated for 12 weeks with normal chow, normal chow plus N-acetyl cysteine (1.5 g/day/kg), fructose (60% of diet), and fructose plus N-acetyl cysteine. After 10 weeks, plasma triglyceride and 15-F2t-isoprostane, and insulin sensitivity were measured, and after 12 weeks, pressor response to methoxamine (15-60 microg/kg min) was assessed. Relative to normal chow-fed controls, the fructose-fed rats had increased blood pressure, plasma insulin, triglyceride and 15-F2t-isoprostane, and decreased insulin sensitivity; these changes were inhibited by N-acetyl cysteine. Maximal pressor response to methoxamine was attenuated in the fructose-fed rats given N-acetyl cysteine relative to the other three groups. Therefore, chronic treatment with N-acetyl cysteine increases insulin sensitivity and prevents the blood pressure increase associated with fructose feeding in rats, the mechanism may involve the decrease of oxidative stress and alpha-adrenoceptor-mediated vasoconstriction.
Eur J Pharmacol. 2005 Jan 31;508(1-3):205-10
Prolonged treatment with N-acetyl cysteine and L-arginine restores gonadal function in patients with polycystic ovary syndrome.
Nitric oxide (NO) plays a wide spectrum of biological actions including a positive role in oocyte maturation and ovulation. Free radicals levels have been shown elevated in polycystic ovary syndrome (PCOS) and therefore would be responsible for quenching NO that, in turn, would play a role in determining oligo- or amenorrhea connoting PCOS. Eight patients with PCOS displaying oligo-amenorrhea from at least 1 yr underwent a combined treatment with N-acetyl cysteine (NAC) (1200 mg/die) plus L-arginine (ARG) (1600 mg/die) for 6 months. Menstrual function, glucose and insulin levels, and, in turn, homeostasis model assessment (HOMA) index were monitored. Menstrual function was at some extent restored as indicated by the number of uterine bleedings under treatment (3.00, 0.18-5.83 vs 0.00, 0.00-0.83; p<0.02). Also, a well-defined biphasic pattern in the basal body temperature suggested ovulatory cycles. The HOMA index decreased under treatment (2.12, 1.46-4.42 vs 3.48, 1.62-5.95; p<0.05). In conclusion, this preliminary, open study suggests that prolonged treatment with NAC+ARG might restore gonadal function in PCOS. This effect seems associated to an improvement in insulin sensitivity.
J Endocrinol Invest. 2009 Dec;32(11):870-2
N-acetyl cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome.
OBJECTIVE: To evaluate the effect of N-acetyl cysteine (NAC) on insulin secretion and peripheral insulin resistance in subjects with polycystic ovary syndrome (PCOS). DESIGN: Prospective data analysis. SETTING: Volunteer women in an academic research environment. PATIENT(S): Six lean and 31 obese subjects, aged 19-33 years. INTERVENTION(S): Patients were treated for 5-6 weeks with NAC at a dose of 1.8 g/day orally. A dose of 3 g/day was arbitrarily chosen for massively obese subjects. Six of 31 obese patients with PCOS were treated with placebo and served as controls. MAIN OUTCOME MEASURE(S): Before and after the treatment period, the hormonal and lipid blood profile and insulin sensitivity, assessed by an hyperinsulinemic euglycemic clamp, were evaluated and an oral glucose tolerance test (OGTT) was performed. RESULT(S): Fasting glucose, fasting insulin, and glucose area under curve (AUC) were unchanged after treatment. Insulin AUC after OGTT was significantly reduced, and the peripheral insulin sensitivity increased after NAC administration, whereas the hepatic insulin extraction was unaffected. The NAC treatment induced a significant fall in T levels and in free androgen index values (P<.05). In analyzing patients according to their insulinemic response to OGTT, normoinsulinemic subjects and placebo-treated patients did not show any modification of the above parameters, whereas a significant improvement was observed in hyperinsulinemic subjects. CONCLUSION(S): NAC may be a new treatment for the improvement of insulin circulating levels and insulin sensitivity in hyperinsulinemic patients with polycystic ovary syndrome.
Fertil Steril. 2002 Jun;77(6):1128-35
N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway.
N-acetyl cysteine (NAC) and penicillamine (PEN) have been shown to induce apoptosis in multiple types of human cancer cells; however, the molecular mechanism underlying this activity is unclear. This study was designed to identify the genes responsible for apoptosis induction by NAC and PEN. We found that glucose-regulated protein 78 (GRP78) was upregulated in HeLa cells following treatment with NAC or PEN. GRP78 is a central regulator of endoplasmic reticulum (ER) stress and has been used as a marker of ER stress. Additionally, both the activating transcription factor 6 (ATF6) protein and X box-binding protein 1 (XBP1) mRNA were processed, which facilitates the expression of C/EBP homologous protein (CHOP), a key-signaling component of ER stress-induced apoptosis. Furthermore, the PERK-ATF4 pathway, which also induces the expression of CHOP, was activated in NAC-treated cells. The role of the ER stress pathway was further confirmed through the small interfering RNA (siRNA)-mediated knockdown of CHOP, which attenuated NAC and PEN-induced apoptosis. These results demonstrate that NAC- and PEN-induced apoptosis in HeLa cells is mediated by the ER stress pathway.
Mol Carcinog. 2010 Jan;49(1):68-74
N-acetyl cysteine inhibits human signet ring cell gastric cancer cell line (SJ-89) cell growth by inducing apoptosis and DNA synthesis arrest.
BACKGROUND AND AIMS: In this study, we investigated the inhibitory effects of N-acetyl cysteine (NAC) on the growth of the human signet ring cell from the gastric-cancer cell line SJ-89 , via the induction of apoptosis and the arrest of DNA synthesis. MATERIALS AND METHODS: SJ-89 cells were regularly incubated in the presence of NAC at 5, 10 and 20 mmol/l, and with IMDM as untreated control. Trypan blue-dye exclusion analysis and 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide assay were applied to detect cell proliferation. Apoptotic morphology was observed by electron microscopy. Flow cytometry and terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling (TUNEL) assay were performed to detect NAC-triggered apoptosis. RESULTS: NAC could inhibit proliferation of human gastric cancer SJ-89 cells in a dose-dependent and time-dependent manner. The growth curve showed suppression by 15.8, 37.6, and 66.3% following 72 h of NAC treatment at 5, 10 and 20 mmol/l, respectively, similar to the findings of 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide assay. DNA synthesis was evidently reduced by 25, 39, and 91% after 24 h NAC treated at 20 mmol/l and 5 days at 10 and 20 mmol/l, respectively. Cell growth was inhibited by 100% with the treatment of 20 mmol/l NAC on day 6. NAC-treated SJ-89 cells were characterized by typical apoptotic alterations, including morphological changes by electron microscopy, typical apoptotic sub-G1 peaking observed by flow cytometry and increase of apoptotic cells with the elevation of the concentration of NAC in a clearly dose-dependent manner by TUNEL assay. Electrophoresis analysis showed typical 'DNA ladder'. CONCLUSION: The data above implicated that NAC inhibits human gastric-cancer SJ-89 cell growth by inducing apoptosis and DNA synthesis arrest. Although the exact mechanisms involved in NAC-induced apoptosis have not been known up to now, the ability to induce apoptosis in a tumor-cell population within 48 h is worth noting. It is also noteworthy that NAC can selectively inhibit the growth of tumor cells. Further studies are needed to elucidate the mechanisms.
Eur J Gastroenterol Hepatol. 2007 Sep;19(9):769-74
Antioxidants tiron and N-acetyl cysteine differentially mediate apoptosis in melanoma cells via a reactive oxygen species-independent NF-kappaB pathway.
Tiron and N-acetyl cysteine (NAC) have been recognized as potential antioxidants capable of inhibiting apoptosis induced by reactive oxygen species (ROS). Although the ROS-scavenging function of tiron and NAC is clear, the mechanism for their regulation of apoptosis is still elusive. Here we demonstrate that tiron increases nuclear factor-kappaB (NF-kappaB)/DNA binding and as a result enhances NF-kappaB transcriptional activity. In contrast, NAC inhibits NF-kappaB activation by reducing inhibitor of kappaB kinase (IKK) activity. Moreover, the expression of an NF-kappaB target gene, the chemokine CXCL1, is promoted by tiron and suppressed by NAC. Finally, tiron confers an antiapoptotic function, while NAC imparts a proapoptotic function in melanoma cells. These functions correlate with the alteration of mitochondrial membrane potential but not ROS production or induction of activating protein-1 (AP-1). This study underscores the potential benefits of regulating NF-kappaB activity in melanoma cells as a therapeutic approach.
Free Radic Biol Med. 2007 May 1;42(9):1369-80
N-acetyl cysteine fosters inactivation and transfer to endolysosomes of c-Src.
The non-receptor-protein tyrosine kinase c-Src is overexpressed and activated in a large number of human cancers, in which it is associated with tumor development and progression. Canonical regulation takes place by means of an alternative phosphorylation of tyrosine residues—Tyr419 for activation and Tyr530 for inactivation. An independent redox regulation mechanism, involving cysteine residues, has also been proposed, in which oxidation activates the enzyme. Here we present a kinetic analysis of the effect of N-acetyl cysteine (NAC) on c-Src, demonstrating that reduction reverts the oxidation-driven activation. In cancer cells, we show that NAC treatment produces an increase in specifically labeled reduced thiols of c-Src cysteines, thus confirming a redox transition. In addition to a decrease in Tyr419 phosphorylation, this leads to a massive shift of c-Src from plasma membranes—where its active form is located—to endolysosomal compartments. With the objective of deciphering the complex issue of c-Src regulation and of devising new strategies to revert its activation in cancers, redox regulation thus emerges as a promising area for study.
Free Radic Biol Med. 2008 Dec 1;45(11):1566-72
N-acetyl cysteine protects against ionizing radiation-induced DNA damage but not against cell killing in yeast and mammals.
Ionizing radiation (IR) induces DNA strand breaks leading to cell death or deleterious genome rearrangements. In the present study, we examined the role of N-acetyl cysteine (NAC), a clinically proven safe agent, for it's ability to protect against gamma-ray-induced DNA strand breaks and/or DNA deletions in yeast and mammals. In the yeast Saccharomyces cerevisiae, DNA deletions were scored by reversion to histidine prototrophy. Human lymphoblastoid cells were examined for the frequency of gamma-H2AX foci formation, indicative of DNA double strand break formation. DNA strand breaks were also measured in mouse peripheral blood by the alkaline comet assay. In yeast, NAC reduced the frequency of IR-induced DNA deletions. However, NAC did not protect against cell death. NAC also reduced gamma-H2AX foci formation in human lymphoblastoid cells but had no protective effect in the colony survival assay. NAC administration via drinking water fully protected against DNA strand breaks in mice whole-body irradiated with 1Gy but not with 4Gy. NAC treatment in the absence of irradiation was not genotoxic. These data suggest that, given the safety and efficacy of NAC in humans, NAC may be useful in radiation therapy to prevent radiation-mediated genotoxicity, but does not interfere with efficient cancer cell killing.
Mutat Res. 2009 Jun 1;665(1-2):37-43
Prevention of cigarette smoke-induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N-acetyl cysteine.
Lung cancer is the most important cause of death among neoplastic diseases worldwide, and cigarette smoke (CS) is the major risk factor for cancer. Complementarily to avoidance of exposure to CS, chemoprevention will lower the risk of cancer in passive smokers, ex-smokers, and addicted current smokers who fail to quit smoking. Unfortunately, chemoprevention clinical trials have produced disappointing results to date and, until recently, a suitable animal model evaluating CS carcinogenicity was not available. We previously demonstrated that mainstream CS induces a potent carcinogenic response when exposure of mice starts at birth. In the present study, neonatal mice (strain H) were exposed to CS for 120 consecutive days, starting at birth. The chemopreventive agents budesonide (2.4 mg/kg diet), phenethyl isothiocyanate (PEITC, 1,000 mg/kg diet), and N-acetyl cysteine (NAC, 1,000 mg/kg body weight) were administered orally according to various protocols. The experiment was stopped after 210 days. Exposure to CS resulted in a high incidence and multiplicity of benign lung tumors and in significant increases of malignant lung tumors and other histopathological alterations. All three chemopreventive agents, administered to current smokers after weaning, were quite effective in protecting both male and female mice from CS pulmonary carcinogenicity. When given to ex-smokers after withdrawal of exposure to CS, the protective capacity of budesonide was unchanged, while PEITC lost part of its cancer chemopreventive activity. In conclusion, the proposed experimental model provides convincing evidence that it is possible to prevent CS-induced lung cancer by means of dietary and pharmacological agents.
Int J Cancer. 2010 Mar 1;126(5):1047-54
N-acetyl cysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stage.
N-acetyl cysteine (NAC) and S-methylcysteine (SMC), water soluble organosulfur compounds contained in garlic, were evaluated for chemoprevention of hepatocarcinogenesis after 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) initiation in rats. Intergastric treatment with NAC or SMC five times a week resulted in decreased numbers and areas of preneoplastic, glutathione S-transferase placental form (GST-P) positive foci of the liver in a dose-dependent manner. Moreover, cell proliferation was reduced in GST-P positive foci by NAC and SMC. Insulin-like growth factor I (IGF-I) and inducible nitric oxide synthase (iNOS) mRNA expressions were found downregulated in the liver by NAC. The studies indicate that NAC can serve as a chemopreventive agent for rat hepatocarcinogenesis induced by MeIQx by reducing cell proliferation, which may involve IGF-I and iNOS downregulation.
Carcinogenesis. 2006 May;27(5):982-8


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Former Raiders wide receiver Tim Brown had some interesting observations regarding the return of Charles Woodson Thurdsay night as well as his own induction into the Bay Area Sports Hall of Fame.
Brown was a teammate of Woodson, who came back to the Raiders Tuesday as a free agent, and was also a fellow Heisman Trophy winner. When they played together, Brown was the consummate family man while Woodson was single and more of a man-about-town, someone who came to play on Sundays but wasn't necessarily as involved Monday through Saturday.
Yet Brown, in a late-January conversation, never had any issue with Woodson because he came to play every Sunday.
Dan Brown of this newspaper caught up with Brown at the BASHOF ceremonies Tuesday night, and this is how Brown reacted to Woodson's return to Oakland:
"I think it's great. I think for C-Wood, it was probably the only move that he could have made," Brown said. "Once you get up there in age, you saw what (Brian) Urlacher did. He just said, 'I don't want to put on another jersey.'
"I think when you get up there in age, you want look around and say, 'OK, I have to go some place where I'm comfortable. Because I'm not trying to learn new people at 36 years old.' That's why I chose to be with (Jon) Gruden because it was someone I knew and there were five or six players that I knew very well. So it was a comfortable environment for me.
"For him, coming back here is going to be great. He has a chance to kind of right some of those wrongs that he had while he was here. I don't know if he was the leader back then that he ended up being in Green Bay. So now he gets to come back here and fix everything he needs to fix and go out on a high level."
Brown, who has been denied in his first three attempts at the Pro Football Hall of Fame, conceded he hadn't given much thought about the signifcance of the Bay Area Sports Hall of Fame until given some perspective.
"Initially, I'm like, "OK. All right." Because at that time I was waiting to see about the Pro Football Hall of Fame.
"But somebody who is a baseball fan said, 'Dude, you're going to be in a friggin' Hall of Fame with Willie Mays.' I'm like, 'Whoa.' It just sort of changed the whole perspective of what this is about. This is not a football Hall of Fame. This is a Bay Area sports deal. And from that standpoint, we really started to look forward to this night."
Brown said the selection of Fred Biletnikoff to present him at the ceremony was an easy one.
"To me, it was the only choice. Freddy was, what did I play, 15-16 years with the Raiders, and he saw the whole maturation process," Brown said. "From struggling coming off my knee injury to being just happy be on the field to wanting to play hard and until the end of the 16 years.
"From that standpoint, I needed him to be part of the ceremony tonight. Whatever he's going to say, he's going to say because it's not or ever was about his words. It's just about him being part of the ceremony."
Brown's most cherished moment as a Raider?
"I think for me it was making it to the Super Bowl. We always felt it was us versus the world," Brown said. "Us winning 12 games felt like winning 20 games. So I think to overcome everything we needed to overcome and still make it there was quite a moment of accomplishment on all of our parts."


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AfriGeneas Genealogy and History Forum Archive
A Great Project
In Response To: County Genealogy Project - Champaign County, Ohio ()
Letters of support are coming in your direction, Art.
What a difference it would make if such a project could be initiated in all local communities across the nation.
Messages In This Thread


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Ratings: The Walking Dead Kills Cable Records
Bow before your zombie master.
The zombie takeover of TV continues: Sunday's season-three premiere of The Walking Dead drew a drop-dead amazing 10.9 million viewers to AMC at 9 p.m., shattering all sorts of records in the process. Not only was it the most-watched episode ever of the show, it was also the most-watched episode of any basic cable drama series ever. And among viewers under 50, Dead drew 7.3 million viewers, garnering higher Nielsen numbers than stalwarts such as Modern Family, The Voice, and The Big Bang Theory.
Want more superlatives? Okay: Not only did Dead beat every entertainment show on network TV Sunday, it was also up 20 percent from last spring's season two finale (9 million) and a jaw-dropping 50 percent versus last fall's season two debut (7.3 million). Also, if you toss in last night's encore telecasts, Dead actually reached 15.2 million viewers (with more to be counted via DVR and video on demand). But here's our favorite factoid about the show's ratings performance: If you add up tune-in for the most recent season-premiere episode of AMC's Mad Men (3.5 million), Breaking Bad (2.9 million), Hell on Wheels (2.5 million), and since-canceled The Killing (1.8 million), you get 10.7 million viewers — still 200,000 viewers below the ratings of last night's monster mash. AMC should be very, very grateful for Dead.


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Concerns about cloud security have helped dampen enthusiasm for cloud computing among some IT professionals, a perception that Microsoft hopes to reverse with some findings from a study it recently commissioned. The study was conducted in India, Hong Kong, Malaysia, Singapore, and the United States. Study participants consisted of small and mid-sized business (SMB) which were using (and not using) cloud services. Microsoft released the U.S. survey results today, and plans to release results from other countries in the next few weeks.
I spoke with Tim Rains, Director of Microsoft Trustworthy Computing, and he suggested that the survey results prove that security -- rather than being a negative for cloud computing adoption -- is actually turning into a positive for cloud computing adopters. "This study shows that businesses that use the cloud get savings in time and money, but they also get increased levels of security," Rains said. "Security [concerns] have been a barrier to cloud adoption, but the study shows that users are gaining security rather than losing it."
A Microsoft statement outlines some of the key findings of the study, namely:
The study shows that 35 percent of U.S. companies surveyed have experienced noticeably higher levels of security since moving to the cloud.1 In addition, 32 percent say they spend less time worrying about the threat of cyberattacks. U.S. SMBs using the cloud also spend 32 percent less time each week managing security than companies not using the cloud. They are also five times more likely to have reduced what they spend on managing security as a percentage of overall IT budget.
For more information on the Microsoft cloud security study, read a blog post on Technet by Adrienne Hall, General Manager of Microsoft's Trustworthy Computing Group, or peruse the details in the related Microsoft news release.
So what do you think of Microsoft's cloud computing security study results? Share your thoughts by adding a comment to this blog post or contributing to the discussion on Twitter.
- Follow Jeff James on Twitter at @jeffjames3 – Google+ add Jeff to your circles
- Follow Windows IT Pro on Twitter at @windowsitpro


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LAKEVILLE — The last time the Old Rochester girls tennis team lost a regular season match, George W. Bush was President of the United States, Manny Ramirez was batting cleanup for the Boston Red Sox and Kevin Garnett was still a member of the Minnesota Timberwolves.
LAKEVILLE — The last time the Old Rochester girls tennis team lost a regular season match, George W. Bush was President of the United States, Manny Ramirez was batting cleanup for the Boston Red Sox and Kevin Garnett was still a member of the Minnesota Timberwolves.
The Bulldogs' 111-match win streak was snapped when they fell to Apponequet 4-1 on Wednesday. ORR's last regular-season loss came in 2006, also to the Lakers, when the members of the current squad were in elementary school.
"I told the girls, 'It's better to lose a match like this than win 5-0 and not lose a game," said ORR head coach Bob Hohne. "We'll learn more about ourselves from this game than all of our other matches combined."
While the Bulldogs (7-1, 6-1 SCC) were dejected by the defeat, Apponequet was elated to finally be able to knock off ORR.
"These kids have wanted this for so long," said Lakers head coach Ken Lanyon. "I told them go out and play your best. I'm proud of all of them."
The Lakers (8-0, 7-0 SCC) secured the team win after sophomore Jenna Lahaie defeated Julia Nojeim 6-2, 2-6, 6-3 at second singles.
"It was Jenna's game to win," said Lanyon. "The match was in her hands. I told her, 'It's up to you. You can end it right here and she did.'"
Lanyon said Lahaie has grown three inches in the last year and it has made a noticeable difference in her tennis game.
"She's got a great serve," said Lanyon.
Hohne said while the Bulldogs still have top-notch players like senior Abby Offringa at first singles, they are not as deep as they have been in year's past. Offringa scored the lone win for ORR with a 6-0, 6-1 decision over April Locke.
"Over the years we've had better balance on the team, especially at doubles," said Hohne. "We've got two kids just starting to play tennis. (Haley) Dickerson and (Morgan) Middleton are brand new. They are not only learning strategies for doubles but strokes for doubles. In the two close matches that makes a difference."
Dickerson and Kristen Nascimento fell to Jen Vachon and Jenna Price 7-6, 7-6 at first doubles, and Middleton and Jillian Reichert lost to Emma Hays and Sally Greene 4-6, 6-1, 6-1 at second doubles.
For Vachon and Price, both seniors, this was the first win of their career against ORR.
"Both sets were tiebreakers," said Lanyon. "I haven't even thought about how well they played today."
Lanyon said since the ORR streak started, they have had a number of competitive matches, but typically could only register one victory. He knew his current squad could get over the hump if everyone played their "A" game.
"Old Rochester is tremendous," said Lanyon. "Bob does such a good job. Usually teams get intimidated by them because they are so good. My kids have worked very hard on strategies and they wanted to play this match. I couldn't be happier."
The good news for Old Rochester is the Bulldogs have another crack at the Lakers. The two squads will close out the regular season with a showdown at Old Rochester on May 23.
"We have a crack at them at our place and we'll have more experience at that point," said Hohne.
LAKERS HAVE TOUGH ROAD TO SCC CROWN: In addition to the rematch with the Bulldogs, Apponequet will have to beat a tough Fairhaven squad and a Case team with excellent players at first and second singles. "There's still a lot of work to be done," said Lanyon. "This is great, but we've got our work cut out for us."
MYSTIQUE DURING THE STREAK: Hohne feels that some of ORR's opponents have been intimidated by the Bulldogs, conceding defeat before the first serve of the match. He hopes this loss proves to his squad they cannot rest on their laurels. "We are spoiled by our success," said Hohne. "When we show up it's been an automatic win. These kids need to learn they've got to put the effort in to make sure they do win."
NOTES: Old Rochester has won every league title since 2004. The Lakers only lost two matches in 2012, both coming at the hands of ORR. At third singles, Apponequet's Addie Kendall defeated ORR's Casey Garstang 3-6, 6-2, 6-2.
UP NEXT: Old Rochester travels to Dighton-Rehoboth on Friday and Apponequet hosts the Falcons on Monday.


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TOKYO (AP) — Former Japanese Prime Minister Shinzo Abe said Wednesday that he will spearhead an economic recovery and strengthen Japan's military if his conservative party regains control in elections next month.
"We will recover Japan," Abe told a news conference at his party headquarters in Tokyo. "We will rebuild the economy."
Abe, head of the opposition Liberal Democratic Party, is considered the most likely candidate to become prime minister following the Dec. 16 elections. Polls indicate his party will win the most seats but will need to form a coalition to govern.
He promised to achieve 3 percent economic growth through intensive reform programs over the next five years. He also set a 2 percent inflation target, promising to introduce bold monetary policies to get the country out of deflation.
Prime Minister Yoshihiko Noda dissolved the lower house of parliament Friday, paving the way for elections. His ruling party is expected to give way to a weak coalition government divided over how to tackle Japan's myriad problems. The biggest tasks are reviving the stagnant economy, rebuilding after the crippling March 2011 earthquake and tsunami, and determining Japan's energy policy after the disasters-led Fukushima nuclear crisis.
Abe, 58, said he will introduce new economic measures to fight deflation and correct the strong yen, which is hurting Japanese manufacturers and exporters. He promised to compile a large-scale budget to create jobs, promote investment and make Japanese manufacturers more competitive.
Abe also said he would set up a national security council at the prime minister's office to beef up Japan's defense and security amid an escalating territorial spat with China over a set of East China Sea islands. He singled out North Korea, China and Russia as regional security concerns and said his party would increase the defense budget and strengthen the coast guard around the disputed islands.
Abe, the grandson of a World War II minister and convicted war criminal who later became prime minister, has angered China and South Korea because of his sympathetic views toward Japan's militaristic past.
A staunch supporter of the Japan-U.S. alliance, he renewed his call for a revision of Japan's war-renouncing constitution to allow Japanese troops to defend American troops in case of foreign attacks on Japan.
Abe resigned as prime minister in 2007 after a year in office due to a stomach ailment.
His party, which suffered a bitter defeat by Noda's Democratic Party of Japan three years ago, has led recent polls. The DPJ has lost support largely because of its handling of the Fukushima nuclear crisis and its doubling of the sales tax.
Due to party infighting and policy disagreements, the DPJ has lost dozens of members since the summer. Former DPJ Prime Minister Yukio Hatoyama announced his retirement from politics Wednesday after failing to gain the party's backing to run in next month's elections due to his opposition to tax reforms.
If Noda's centrist party loses the elections, Japan will get its seventh prime minister in six and a half years.
Japan is in political transition with a merry-go-round of leaders and mushrooming fringe parties. Nearly half of all voters are undecided and emerging "third force" groups are expected to affect post-election alliances.


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May 16, 2010 at 11:12 am
Hey bud thanks for sending me the summit / Bandit pics, those are way cool! I am going to try for the 2012 if things are still happening!
Great pics dude!
Great pics dude!
Feb 25, 2010 at 3:19 pm
awesome bird. It is great to see people out enjoying the cars they build. Welcome to the site I hope you enjoy it.
Feb 25, 2010 at 5:11 am
Love the stance on your 69! Welcome to Motortopia!


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Transformer Prime owners have been complaining about GPS issues basically since launch. As with most complaints of this kind there were many that didn't seem to experience the problem at all, while others found it intolerable. Prime owners in the UK were actually already given the option to return their Prime for a refund as a result of this issue or if they chose to keep it were given a six month extension on their warranty.
ASUS subsequently tried unsuccessfully to correct the problem with firmware updates, but the general issue as outlined by Anandtech back in January is the aluminum body of the Prime hindering the GPS reception. Not surprisingly it takes a hardware solution to deal with a hardware problem and that is exactly what ASUS will unveil on April 16th.
The rumor is that the dongle will attach via the proprietary dock connection on the Prime and that it is fairly unobtrusive[1]. If you make heavy use of the dock for the keyboard that would seem like a bit of an annoyance, but I suppose if you really need solid GPS performance out of your Prime that is probably a tradeoff you are willing to make.
Prime owners will be able to register on the 16th and according to the ASUS representative the dongle itself should be shipping approximately two weeks later.
I know we have a fair number of Prime owners around here; has this been a big problem for you and if so are you happy with ASUS's solution?
- Land of Droid captured the brief description of the dongle and the planned mid-April release from an XDA thread before it was taken down. ↩


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Business Travel Accident Insurance
Policy Information
- Issue Date: July 1, 1997
- Primary Contact: Director of Human Resources and EEO Officer
- Senior Administration: President and Director
- Responsible Office: Human Resources
ContentsPolicy Information
OverviewI. General
A. The Institution provides Business Travel Accident coverage for all employees while traveling on Institution business, Guest Divers who are properly certified and all other Guests while on a trip at the direction and expense of the Institution, and Senior Scientists who are retired and/or on the Supplemental Retirement Plan and who are traveling on behalf of the Institution. This insurance is paid entirely by the Institution.II. Coverage
B. This insurance covers the eligible individual when business travel is authorized or at the direction of the Institution, and requires the insured to be away from the premises to which s/he is regularly assigned. In addition to coverage while traveling by a traditional means (e.g. automobile, bus, train, commercial airline), coverage also includes travel on water conveyances as a pilot, passenger, crew member or member of a scientific party as well as travel as a pilot, passenger, crew member or observer in any aircraft owned, operated or leased by the Institution.
C. A business trip begins when the insured leaves her/his residence or place of regular employment (whichever occurs last), and continues until the insured returns to her/his residence or place of regular employment (whichever occurs first). Everyday travel between an insured's residence and place of regular employment or while on vacation or personal business is not covered.
A. All active employees are covered at three times the insured's Annual Base Salary rounded to the next higher $1,000 if not already at a multiple thereof. The minimum benefit is $50,000; the maximum benefit is $500,000.III. Benefits
B. Guest Divers who are properly certified and all other Guests while on a trip at the direction of the Institution are covered for $50,000.
C. Senior Scientists who are retired and/or on the Supplemental Retirement Plan, and who are traveling on behalf of the Institution, are covered for $250,000.
A. Death and Dismemberment - Each insured is covered for loss of life or bodily member. A "member" is defined as a hand, foot, eye, or one's speech or hearing. The loss must be as the result of a covered accident.
B. The Principal Sum applicable to an insured shall be based on the following percentages:
|Age at Loss
|Rate of Principal Sum
|Less than age 75
|Age 75 but less than 80
|Age 80 or more
C. Permanent Total Disability - Only active employees under age 70 are covered in the event of an injury which results in Permanent Total Disability. "Permanent Total Disability" is defined as the inability to engage in any substantial gainful occupation or employment for the remainder of the insured's lifetime. This benefit is payable to an insured who, within 180 days of a covered injury, is totally Disabled, whose Disability is continuous for one full year, and at the end of that year is Permanently Totally Disabled.IV. Exclusions
D. If a benefit is payable for more than one hazard, only the largest benefit payable as a result of a covered accident will be paid.
Coverage is not provided for any loss resulting from:
A. Illness or disease except bacterial infection arising out of an accidental cut or wound;
B. Committing or attempting to commit a felony or act of violence or participation in civil disobedience, civil disorder, riot or insurrection;
C. Suicide or self-inflicted injury whether sane or insane;
D. An accident occurring while serving in any military or other organized armed forces;
E. Travel or flight in any vehicle or device beyond the earth's atmosphere; in a rocket-propelled aircraft; in a craft being used for crop dusting, seeding, spraying, firefighting, pipe or power line inspection, hunting or banner towing; flying that requires a special permit or waiver from an authority having jurisdiction over civil aviation; acrobatic or stunt flying; or in any aircraft while giving or receiving any training or instruction.
[go back]


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Lorraine Warner, 77 - May 21, 2008
Lorraine Margaret Warner, 77, of Gothenburg died Sunday, May 18, 2008, at Gothenburg.
Services were held on Wednesday at 1:30 p.m. at the American Lutheran Church, 1512 Ave. G, Gothenburg with Lonna Grabenstein, PMA, officiating. Burial will be at Fort McPherson National Cemetery at 3 p.m.
Warner was born Oct. 15, 1930, at Freedom to Knowles and Lillian (Johnson) Bush. She grew up on a family farm northwest of Bartley and attended school at Farnam. She lived at Farnam and Lexington, and graduated from Lexington High School.
On Aug. 27, 1950, she was united in marriage to Ben Warner at Lexington. To this union, five children were born.
She was employed at Evans Bakery, Slacks Nursing Home and at Hilltop Estates.
Warner was a member of the American Lutheran Church.
She enjoyed spending time with family, crocheting and flowers, according to family members.
Warner was preceded in death by: her parents, Knowles and Lillian; a brother, Jerold; sister-in-law, Retha Johnson; grandson, Joshua Dale Warner.
?Survivors include: her husband, Ben of Gothenburg; sons—Lonnie (Sandy) Warner and Brad (Michele) Warner, all of Gothenburg; daughters—Patricia (Duane) Stevens of Sumner, Linda (Eldon) Rodine and Pamela (Michael) Houchin, all of Gothenburg; brother, Marion Johnson of Curtis; sister, Elaine (Bill) Holliday of Lexington; 10 grandchildren—Leigh Ann (Charles) Taylor, Derek Rodine, Kiel (Lacey) Stevens, Kasia Stevens, Adam and Caleb Warner, James (Mia) Houchin, Travis Houchin and Joseph and Raymond Warner; seven great-grandchildren; numerous nieces and nephews.
Memorials are suggested to the American Lutheran Church window fund and diabetes research.
Online condolences may be sent to the family at www.blase strauser.com. Arrangements have been placed in the care of Blase-Strauser Memorial Chapel of Gothenburg.
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text: Book | 2012 Strategic IQ: Creating Smarter Corporations John R. Wells In today's world, only the smartest survive. The competitive landscape is littered with graves of well-known firms whose revenues, profits and stock prices rose for decades until they suddenly imploded. In fast-changing business environments, firms must adapt their strategies and innovate to remain at the top. But many successful firms fail to do so. Instead, they succumb to inertia, hesitate, or stick blindly to their old strategies, until it is too late. The ability to adapt to change is a measure of intelligence; so why do firms demonstrate such low Strategic IQ? What causes inertia and why is it so deadly? How can leaders help their firms to act more intelligently? This book identifies the key sources of inertia—strategic, structural and human—and provides practical advice on how they can be overcome to create smarter corporations. It is both a wake-up call for successful firms and a lifeline for firms struggling to succeed. To successful firms—beware! You may already be dead! To struggling firms—have hope! It is possible to pass powerful competitors by raising your strategic, structural and human IQ. Keywords: Organizational Change and Adaptation; Change Management; Competition; Business Growth and Maturation; Adaptation; Corporate Strategy; Decision Making; Innovation and Invention; Citation: Wells, John R. Strategic IQ: Creating Smarter Corporations. San Francisco, CA: Jossey-Bass, 2012. View Details CiteView DetailsPurchase Related


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search.fantastigames.com/465 Redirect? When you open your browser and find that some weird icons and search bar have been added on the top of your favorite browser. This toolbar is added stealthily on your browser without your notice and permission. Like a normal search engine, there is a "search" bar on the midst of the site. On the upper left corner, some linkable letters shows up as Web,Images,Videos,News. Here is a question, is it a legitimate site or just something else associated with computer virus? There are so many evidences prove that it can be defined as redirect virus. It has been mentioned in extermination failure complaints posted by many PC users. In spite of most of the computers have installed anti-virus, none of them were able to identify and describe the problem; so, they did not succeed in exterminating components of the redirect virus. That's why PC users who have top antivirus installed on the infected PC but not seemingly have chance to remove the virus. Besides, you may find numerous problems in using your browser such as internet explorer and firefox, etc. after that weird icon added on your computer. It is opened more and more slowly. You can never use the search engine normally as usual. Even when you open some normal legitimate web sites, you are always redirected to search.fantastigames.com/465 Redirect or some strange advertisement pages. If you have those symptoms, unfortunately, your PC has infected with a browse hijacker search.fantastigames.com/465 Redirect.
search.fantastigames.com/465 Redirect
search.fantastigames.com/465 Redirect is a new released malicious browser hijacker which will redirect PC user's search results. Recently, many PC users were attacked by an annoying virus called Websearch.good-results.info Redirect Redirect. It was created by hackers aiming to spread some ads by infecting computers. People infected by this nasty virus by chance through drive-by download from the infected web pages. When you visited and downloaded things from the infected web pages, which will make you expose into highly danger situation and caught this virus. This browser hijacker which can modify the fault setting of your browser to take over the browser's authorization, change your homepage, block your resources, redirect the search engines to some malicious websites which contain lots of threats such as dangerous links and pop-ups. Once infected by it, every time you try to use your search engines such as Google, Firefox, and IE redirection, your results will always be forced search.fantastigames.com/465 or its related malicious websites, which would constantly molest your system with lots pop-ups and ads. If you think that it is not harmful with the advertisements on its site. Hackers just hope you to click on some of those advertisements on search.fantastigames.com/465 Redirect so that they can make more advertising fees. If you did that then it must be a big mistake you have done. You are definitely underestimated this annoying virus. Little by little, it will gradually slow down your PC and make it runs as a snail damaging you system completely. What is more, the worse news is that the virus is designed to collect user's personal information such as password, credit card number, email address, etc. It will access into your PC through Internet connection without your knowledge. It is confirmed to say that all of your personal information will exposed into a dangerous situation. It is highly recommended that you eliminate this infection as soon as possible before it further messes up your system.
If you failed to remove search.fantastigames.com/465 Redirect , please consult YooCare certified professionals to remove it completely.
A Screenshot of search.fantastigames.com/465 Redirect
Specific features of search.fantastigames.com/465 Redirect
1. search.fantastigames.com/465 Redirect might change your default DNS configuration and Windows hosts file. These actions may lead to the blocking access to particular web resources. As to the web viewer, it is as well exposed to impact of this hijacker.
2. All the settings, among them the default homepage, search system you use, personal bookmarks etc. may be easily and repeatedly customized, in the bad sense.
3. search.fantastigames.com/465 Redirect affects the web search navigation, once the person types a search request and presses the 'Search' button; he is forcibly rerouted either to fake search engines, or to phishing sites with lots of ads, dubious links.
How to Remove search.fantastigames.com/465 Redirect manually?
Please, be informed that manual removal of search.fantastigames.com/465 Redirect is a cumbersome procedure and does not always ensure complete deletion of the it, since some files might be hidden or may automatically reanimate themselves later. If you haven't sufficient expertise in dealing with program files, processes, dll files and registry entries, it may lead to mistakes damaging your system.
Steps1: launch your computer in Safe Mode with Networking
- Remove all floppy disks, CDs, and DVDs from your computer, and then restart your computer.
- After hearing your computer beep once during startup, start pressing the F8 key on your keyboard. On a computer that is configured for booting to multiple operating systems, you can press the F8 key when the Boot Menu appears.
- On the Advanced Boot Options screen, use the arrow keys to highlight SafeMode with Networking , and then press ENTER
Steps2:Press CTRL+ALT+DEL or CTRL+SHIFT+ESC. Open the Windows Task Manager.
If that didn't work, try another way. Press the Start button and click on the Run option. This will start the Run tool. Type in taskMGR and press OK. This should start the Windows Task Manager
Steps 3: Within the Windows Task Manager click on the Processes tab. Find the process by name. random.exe. Then scroll the list to find required process. Select it with your mouse or keyboard and click on the End Process button. This will kill the process.
Step 4: Delete associated files of search.fantastigames.com/465 Redirect:
Step 5: Remove registry entries of search.fantastigames.com/465 Redirect:
HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Policies\System "DisableRegedit" = "".exe.dll
Attention: As can be seen, search.fantastigames.com/465 Redirect thing is an annoying virus which definitely redirects PC browser's search results. Little by little, it will slow down your PC and further harm to mess up your files and damage you system completely. And please don't consider to remove this nasty virus automatically since it can escape all kinds of top antiviruses such as AVG, Norton, Mcafee, Avast, MSE, Spybox, etc. So, don't download unknown so called "free" antivirus, which won't resolve your problem and may lead you to another virus.All the instructions above are prepared for those who have much computer knowledge and are familiar with this kind for virus. If you haven't sufficient expertise in dealing with program files, processes, dll files and registry entries, it may lead to mistakes damaging your system. Before you begin to eliminate such infection, You should think it twice. On the other hand, all the instructions above is aim at the common infection situation. As for search.fantastigames.com/465 Redirect , there are many variables according to different computers. What's worse, as time goes by, search.fantastigames.com/465 Redirect may change itself to other versions, which adds more difficult to the removal . As we mentioned above, this virus infection is a cascaded infection. The related files or may be changed. Unless you specialize in virus removal, to remove a browser hijacker is a complex task.


text:
Booktopia's Romance Specialist asks
Molly McAdams
author of Forgiving Lies
Nine Naughty Questions
1. I wonder, is a romance writer born or made? Please tell us a little about your life before publication.
Haha, uh, great question! I definitely never thought I would be a writer. I failed out of Creative Writing in college. But I've always been a flirt and storyteller, and dated A LOT … and I write a lot of my real life in my books. So I guess born?
2. For all the glitz and the glam associated with the idea of romance novels, writing about and from the heart is personal and very revealing. Do you think this is why romance readers are such devoted fans? And do you ever feel exposed?
I do think so! They get a real-life feel along with the fantasy. And I probably should feel exposed, but I don't. I know if something has happened to me, then its most likely happened to someone else—and maybe by sharing my story, I can help that person.
3. Please tell us about your latest novel…
Forgiving Lies has a little bit of everything: comedy, romance, suspense, thrill factor. I'm so excited for my readers to get this one in their hands, it's different from anything I've written so far.
You can pick up a copy of Forgiving Lies by Molly McAdams here
4. Is the life of a published romance writer… well… romantic?
Read Forgiving Lies and From Ashes. Gage (From Ashes) and Kash (Forgiving Lies) are both made after my hubby. You tell me. 😉
5. Of all of the romantic moments in your life is there one moment, more dear than all the rest, against which you judge all the romantic elements in your writing? If so can you tell us about that special moment?
There is, and I so wish I could tell you … but, unfortunately, I can't. I plan on writing it into one of my stories … don't want to spoil it now.
6. Sex in romance writing today ranges from 'I can't believe they're allowed to publish this stuff' explicit to 'turn the light back on I can see something' mild. How important do you think sex is in a romance novel?
Romance doesn't equal sex. Romance is the love and the passion. Passion and love can both be displayed without sex. But I think its secretly something the readers crave, and for most of our story lines, it's what would happen in that time, so we're going to write it.
7. Romance writers are often romance readers – please tell us your five favourite (read and re-read) romance novels or five novels that influenced your work most?
I can't do five books so I'll do five authors, okay? Haha. (#cheater)
1. Nicholas Sparks
2. A L Jackson
3. Stephenie Meyer
4. Madeline Sheehan
5. Tara Sivec
8. Romance writing is 'so hot right now', do you have any thoughts on why?
I think it will always be hot. Women want an escape, and they want a romantic escape. Who doesn't? It started for us with the Disney fairytale princesses! Haha
9. Lastly, what advice do you give aspiring writers?
Never give up, and always write for yourself!
Thanks for joining us Molly!
Molly McAdams grew up in California but now lives in the oh-so-amazing state of Texas with her husband and furry four-legged daughters. When she's not diving into the world of her characters, she can be found hiding out in her bedroom surrounded by her laptop and cell, and fighting over the TV remote. Molly has published four New Adult novels and is a New York Times bestselling author.


text:
Facts101 is your complete guide to Biology of Humans. In this book, you will learn topics such as The Cell, Body Organization and Homeostasis, The Skeletal System, and The Muscular System plus much more. With key features such as key terms, people and places, Facts101 gives you all the information you need to prepare for your next exam. Our practice tests are specific to the textbook and we have designed tools to make the most of your limited study time.Humans in the World of Biology Chapter 2. Chemistry Comes to Life Chapter 3. TheCell Chapter 4.Body Organization and Homeostasis Chapter 5.The SkeletalSystem ... Evolution and Our Heritage Chapter 23.Ecology, the Environment, and Usanbsp;...
|Biology of Humans
|CTI Reviews
|Cram101 Textbook Reviews - 2016-07-23
You must register with us as either a Registered User before you can Download this Book. You'll be greeted by a simple sign-up page.
Once you have finished the sign-up process, you will be redirected to your download Book page.How it works:


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Saturday September 22, 2018; 11:16 pm EDT
Opposites not only attract, they also repel, making for a timeless comedy
Neil Simon's 1963 romantic comedy Barefoot in the Park was a box office smash on stage and screen, not merely because it starred dreamy Robert Redford but because it's packed with hilarious moments. What's not to get about newlyweds learning the hard lessons of why opposites not only attract but also repel? The story, as old as matrimony, roused braying guffaws of recognition from Compass Rose Studio Theater's mature audience on opening night.
Free-spirited Corie (Brianna Letourneau) and stuffed-shirt Paul (Brandon McCoy) are newlyweds in their first apartment, a decrepit fifth-floor walk-up. Typical for the time, he works hard all day while she pines for him at home, where diversion always rings the doorbell and complains of the climb. Corie's lonely mother Ethel (Lucinda Merry-Browne) drops by unannounced from the suburbs, huffing and puffing and biting her tongue in a most civilized manner. The wheezy telephone repairman (Thomas 'Toby' Hessenauer) dispenses marital advice with his dial tones, along with hilarious physical comedy. And Bohemian neighbor Victor Velasco (R. Scott Williams) accesses his attic garret via their bedroom window.
More than just a friendly inconvenience, the aging Victor presents a virile threat and challenge for Corie, who recognizes in him her own passion for life, which she feels is missing from husband Paul and mother Ethel. So she orchestrates a double date that succeeds too well with the elder set but threatens her own marriage.
It was a great premise for its time: The love-drunk little lady demanding adventure while craving security, the mother and drunken husband learning to loosen up, the drunken outdoorsman injuring himself. There's a lot of cocktail humor in this show, rather as in old Bewitched reruns. Add in the sexism of the era, and this classic feels dated to modern audiences. Judging from the reaction of at least one 20-something, newlyweds don't get excited about playing house anymore. They have babies and buy houses first. Thus, the set-up of Act I is less entertaining than the pay-off of Act II. Still, once the lovers start to quarrel, it's all barbed humor leading to the eternal message that love really is all you need.
This production is special for several reasons. It stars real-life newlyweds who know how to kiss with conviction; both are alumni of Catholic University's theater program, as is director James Phillips. Four of the five actors are Compass Rose veterans, including Merry-Browne, the founding artistic director of the teaching theater company. With its all-adult cast, this show's emphasis on professional performance makes for a smooth two hours of entertaining commentary on matrimony and human nature.


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Skip to comments.Seven Step Campaign To Get The Dem Memo Story Out
Posted on 11/05/2003 7:12:14 PM PST by jmstein7
Seven Step Campaign To Get The Dem Memo Story Out
This time, we the people will not stand for GOP spinelessness. We will not let the GOP simply Move On from the vicious, unethical Dem memo.
If you have not read it yet, click HERE.
If you have not read Zell Millers reaction, click HERE.
1) Click HERE to open the Send Fax window.
2) Cut and paste this phone number AS WRITTEN into the "The FAX Number" field:
1 202 224 3514
3) Address the fax to "Senator Pat Roberts" and don't forget to put your email address where it tells you to or your email will not be sent!
4) Write your own message to the Senator expressing your outrage at the Dem memo, or cut and paste this sample:
Dear Senator,
As a grassroots supporter, I am OUTRAGED at the unwillingness of Republican Senators, the MAJORITY party, to take on the Democrat party on the Democrat memo outlining a political strategy to use the power and resources of the Senate Intelligence Committee as a political tool against our President, and the leader of our party.
I am DISGUSTED by the repeated lack of testicular fortitude of my party's Senators. I am SICKENED by the way the Majority Republicans allow the Minority Democrats to continually steamroll them on EVERY ISSUE.
I, and my cohorts, are the people who put and keep Republican Senators in office. If our party's Senators will not represent and zealously advocate the interests of "we the people" who put you in office, then you can expect a well-funded (by a our various well-organized grassroots organization) primary challenge from a Republican who has what it takes to take on these acid tongued, vicious, partisan Democrats.
So, please, start fighting for us. Take the Democrats head-on. Take to the airwaves. Do what it takes to effectively represent us, your grassroots supporters, or you will risk losing our support.
We are fighters. We have fought hard over the years, collectively, to put you and your peers into office. Please don't forget that, and please return the favor by fighting for us.
Thank you.
5) Click "FAX IT!"
6) Here are other numbers you can fax this to:
Senator Frist 1 202 228 1264
Senator Kyl 1 202 224 2207
Senator McConnell (email) firstname.lastname@example.com
Senator Santorum (webform) santorum.senate.gov/emailrjs.html
7) Email your friends with a link to this page (copy the URL from the address bar at the top of your page and paste it into an email to your friends).
Great Job!!!
It already has. By Friday the Dems will be attacking Bush again like nothing happened. I made anumber of calls today to various Senators and Congressmen's offices. Every reaction was lukewarm at best.
It is vital that the National Republican Senatorial Committee NOT give the Democrats a pass on their planned use of the power and resources of the Senate Intelligence Committee as a political tool against our President!
There are no words strong enough that convey the urgency of this plea. We cannot let this wanton abuse of power and privilege stand. Were anyone save these people caught planning to use sensitive and classified information to the detriment of our government, it would be justly prosecuted for the crime of treason.
I cannot stress enough that the Republicans cannot give the Democrats a pass on this. This situation is absolutely untenable and must be addressed without delay.
Your failure to do take on this serious matter will do nothing to further your cause. If anything, any inaction on this issue will ultimately result in a crisis of confidence in your leadership capacity.
I heard that and wanted to throw up!!
Then Sean goes on about how we Republicans should stand up an make this a big issue. With Sean leading the way tonight on Hannity and Combs we had
3 minutes of John Corzine dodging the issue and 57 minutes of how nothing happened in the Laci Paterson case today (really nothing at all happened with the trial, Everybody had the day off yet they filled the whole program with it)
Way to go Sean! Maybe tomorrow the interview with Laci's dog groomer will be short and we could get a whole 5 minutes to this subject.
Seven Step Campaign To Get The Dem Memo Story Out Thanks, JMStein7 ! Great work ! Let's Freep 'em !!
Please let me know if you want ON or OFF my General Interest ping list!. . .don't be shy.
Thar she blows !! ...
This was a total outrage. I really liked Miller's memo too ! ...
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


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The Freshwater Biodiversity Unit of the IUCN's Species Programme aims to put in place a factual basis for efforts to conserve and manage freshwater biodiversity.
An estimated 126,000 described species rely on freshwater habitats, including species of fishes, molluscs, reptiles, insects, plants, and mammals. With the inclusion of undescribed species, this number could rise to over one million. Species richness in relation to area of habitat is extremely high in many freshwater groups. Freshwater fishes comprise almost 45% of all fishes and freshwater molluscs about 25% of all molluscs. An estimated 15,000 fish (including brackishwater species), 4,300 amphibians, 5,600 Odonata (dragonflies and damselflies), and 5,000 mollusc species depend on freshwater habitats. Other major groups dependent upon freshwater include reptiles, insects, plants, and mammals.
The importance of freshwater species, ecosystems and services to human livelihoods and wellbeing is increasingly being recognised, and the FBU works in a number of areas to provide the information to support decisions for the protection of wetland species and livelihoods.
To conserve and manage freshwater biodiversity, the FBU works in conjunction with the SSC's Specialist Groups (including the IUCN/SSC/WI Freshwater Fish Specialist Group, the Dragonfly Specialist Group and the Mollusc Specialist Group), the Species Information Service, the Global Amphibian Assessment Programme, regional scientists, experts in freshwater biodiversity and policy makers. We have a key partnership with Conservation International's Science & Knowledge division, with which we are working to undertake regional and global freshwater assessments.
For further information on any of our projects, please visit our website.


text:
Federal Financial Institutions Examination Council
|Press Release
|For Immediate Release
|October 7, 1998
Uniform Interagency Trust Rating System
The Task Force on Supervision, acting under delegated authority from the Federal Financial Institutions Examination Council (FFIEC), announced today that it has approved an updated Uniform Interagency Trust Rating System (UITRS), and is recommending that FFIEC member agencies adopt and implement the updated rating system effective January 1, 1999.
The UITRS is an internal supervisory tool used by FFIEC agencies to evaluate the soundness of fiduciary activities of financial institutions on a uniform basis, and to identify those institutions requiring special supervisory attention.
The updated rating system revises the definitions of the composite and component ratings to align the UITRS rating definitions with the language and tone of ratings definitions in the Uniform Financial Institutions Rating System (UFIRS), commonly referred to as the CAMELS rating system. For example, under the current UITRS, a composite 3 rated trust department is considered generally adequate, while under the UFIRS a composite 3 rated bank exhibits some degree of supervisory concern. The updated rating system brings the UITRS in line with the language and tone of the UFIRS.
The revised rating system also places more emphasis on risk management. Changes in the fiduciary services industry have broadened the range of products and services offered and accelerated the pace of transactions. These trends reinforce the need for institutions to have sound risk management processes. Accordingly, the revised rating system contains language in each of the components rated that emphasizes processes to identify, measure, monitor and control risks. The revised rating system takes into account that appropriate risk management practices may vary considerably, depending on the size, complexity, and risk profile of an institution's fiduciary activities.
The number of components in the revised rating system has been reduced from six to five. In addition, under certain conditions, assignment of two of the component ratings may not be required.
The updated UITRS modifies criteria for assigning an earnings component rating. An evaluation of earnings will be required of all institutions. However, a component rating will only be required to be assigned for institutions that have total trust assets in excess of $100 million, and for all non-deposit trust companies. The assignment of an earnings rating is not required for the remainder of institutions. Supervisory agencies may elect, however, to rate the earnings of these smaller departments under an alternate rating system. With this change, the FFIEC recognizes that many small institutions offer fiduciary services primarily as a service to their community, with profitability being a secondary consideration.
The revised UITRS also modifies the criteria for assigning an asset management rating. The rating may not be applicable for some institutions whose operations do not include activities involving the management of any discretionary assets. The rating would, however, still be applicable when the institution provides investment advice, even though it does not have discretion over the account assets.
The revised rating system eliminates the account administration and conflicts of interest components in the previous system. A new compliance component will be used to assess an institution's efforts to comply with applicable laws and regulations, accepted standards of fiduciary conduct including conflicts of interest and self dealing provisions, the terms of governing instruments, and internal policies and procedures.
The updated rating system will be published shortly in the Federal Register.
Maintained by the FFIEC. For suggestions regarding this site, Contact Us.
Last Modified: 08/29/2018 1:11 PM