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Alex TorresSan Francisco Giants
Relief Pitcher | Ht: | Wt: 175
Access our free Fantasy Baseball coverage for more!
|Padres | Joaquin Benoit may land on DL
Thu, 21 Aug 2014 06:05:04 -0700
San Diego Padres CL Joaquin Benoit (shoulder) may land on the 15-dayd disabled list with a sore right shoulder. The team could wait a few more days before making a decision.
Fantasy Tip: Kevin Quackenbush is expected to fill in for Benoit. Pick him up in all leagues if you need a short-term saves fix. Dale Thayer and Alex Torres could also fill in on occasion and are NL-only targets.
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|| Source: MLB.com - Corey Brock
|Padres | Four acquired
Sat, 19 Jul 2014 04:35:57 -0700
Updating previous reports, the San Diego Padres acquired SS Jose Rondon, 2B Taylor Lindsey, RP R.J. Alvarez and a player to be named from the Los Angeles Angels of Anaheim for CL Huston Street and P Trevor Gott.
Fantasy Tip: The Padres will likely go with Joaquin Benoit at closer, but the team is shopping him as well. Alex Torres could also figure into the mix. Grab Benoit in mixed leagues immediately and pick up Torres in NL-only leagues.
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|| Source: MLB.com
|Padres | Alex Torres wears protective headgear during game
Sun, 22 Jun 2014 10:06:23 -0700
San Diego Padres RP Alex Torres became the first player in MLB history to wear the newly-approved headgear for pitchers Saturday, June 21, during a relief appearance against the Los Angeles Dodgers. He ordered it last month and began wearing it occasionally while playing catch last week. "The difference between how this hat and the regular hat feels isn't much," Torres said. "I tried it before using it in the game, playing catch. It doesn't feel really bad. It doesn't feel like how it looks on my head."
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|| Source: MLB.com - Will Laws
|Rays | Logan Forsythe deal completed
Wed, 22 Jan 2014 10:53:06 -0800
The Tampa Bay Rays acquired 2B Logan Forsythe, INF Maxx Tissenbaum and Ps Matt Andriese, Brad Boxberger and Matt Lollis from the San Diego Padres Wednesday, Jan. 22, in exchange for SP Alex Torres and P Jesse Hahn.
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|| Source: FOXSports.com - Ken Rosenthal
|Padres | Alex Torres coming aboard
Wed, 22 Jan 2014 06:09:35 -0800
The San Diego Padres acquired SP Alex Torres from the Tampa Bay Rays in the deal involving 2B Logan Forsythe.
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|| Source: Tampa Bay Times - Marc Topkin
|Rays | Logan Forsythe acquired
Wed, 22 Jan 2014 01:58:07 -0800
The Tampa Bay Rays acquired 3B Logan Forsythe from the San Diego Padres on Tuesday, Jan. 21. The deal is rumored to involve up to five players; the other players were not disclosed, but SP Alexander Torres is rumored to be in the deal.
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|| Source: MLB Daily Dish - Chris Cotillo
|Rays | Alexander Torres called up
Sat, 01 Jun 2013 09:37:32 -0700
The Tampa Bay Rays recalled SP Alexander Torres from the minors Saturday, June 1, and optioned RP Josh Lueke in a corresponding move.
Fantasy Tip: Torres will be used out of the bullpen once again. Chris Archer has been called up to make the start Saturday.
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|| Source: CBSSports.com
|Rays | Alex Colome called up
Wed, 29 May 2013 14:09:02 -0700
The Tampa Bay Rays recalled RP Alex Colome from the minors Wednesday, May 29, to help out their bullpen. The team will need another starter for Saturday, June 1, and SPs Alexander Torres and Chris Archer are the candidates.
Fantasy Tip: Torres was called up recently, but he was used out of the bullpen. Archer is probably the more realistic option after Jake Odorizzi was sent down. Look to add whoever gets the call in AL-only leagues, at least.
|Comment (0)
|| Share:
|| Source: Tampa Bay Times - Marc Topkin
|Rays | David Price to DL
Thu, 16 May 2013 11:44:07 -0700
The Tampa Bay Rays placed SP David Price (triceps) on the 15-day disabled list with a left triceps strain Thursday, May 16, and recalled SP Alexander Torres from the minors in a corresponding move.
Fantasy Tip: Torres could be used to help out in the bullpen in the meantime, so Chris Archer remains a candidate to come up to start Monday and for however long Price is out. Jake Odorizzi pitched Wednesday, so he's on turn, but he pitched poorly in his outing. Archer is the best bet to fill the vacant rotation spot for the short term, and he'll be a popular waiver wire target in AL-only leagues. He's worth a look in deep mixed formats, as well, depending on the matchups.
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|| Source: Tampa Bay Times - Joe Smith
|Rays | Alexander Torres recalled
Thu, 16 May 2013 11:33:25 -0700
The Tampa Bay Rays recalled SP Alexander Torres from Triple-A Durham Thursday, May 16.
Fantasy Tip: Torres could make a spot start in place of David Price (triceps) Monday, but the Rays might be bringing him up to help out in the bullpen in the meantime. Chris Archer remains a possibility to come up for a spot start or two. Both pitchers are worth owning in AL-only leagues, even if it's temporary.
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|| Source: The Sports Network


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Google Unveils Online Health Record Pilot Program
Google and the Cleveland Clinic agreed to partner on a program to store patient health records online. The patients, who volunteered for the electronic transfer of their records, will be able to access their own records. Though all health profiles will be password-protected, critics have accused the program of raising more problems than it solves.
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subset: commoncrawl


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LOS ANGELES (AP) — A federal judge awarded $3 million Wednesday to the parents of a Southern California teen who was fatally shot by Drug Enforcement Administration agents in plainclothes three years ago.
U.S. District Judge Michael Fitzgerald said Wednesday that the DEA agents had reason to believe they were in danger, but it was unreasonable for them to fire at the moving car driven by Zachary Champommier.
The 18-year-old was driving through a Studio City parking lot on June 24, 2010, where members of a drug task force were discussing a search warrant they had just served. Authorities said the agents fired at the teen after he tried to run down a Los Angeles County sheriff's deputy who was a member of the task force.
Champommier's parents claimed in a wrongful-death lawsuit that the agents recklessly shot at their son, who they contended posed no reasonable threat and had no way of knowing whether he was encountering law enforcement officers.
They said Champommier drove his mom's car to the parking lot to meet someone he befriended on a social networking website. The friend went looking for Champommier's white Corolla and became a suspect when he looked into an agent's light-colored vehicle, which had seized guns and drugs.
Agents were in the process of arresting the friend when the deputy approached the scene with his gun drawn.
Champommier's parents claimed the deputy stepped in front of their son's car and "vaulted" on top of its hood like a Hollywood stuntman.
Fitzgerald wrote that within two seconds of the "low-speed impact" of the collision, DEA agent Peter Taylor LoPresti fired through the driver side of the window from about 2 feet away, killing Champommier.
The judge noted that LoPresti "did not articulate at trial exactly how shooting the driver of a moving vehicle while another officer was on the hood would be helpful to the besieged officer."
He found that five subsequent shots fired by LoPresti and the deputy "unquestionably lacked justification."
Champommier's parents said they were gratified by the ruling.
"The finding that the shooting was unjustified was what we wanted; we wanted justice in this case," said Cara Eisenberg, an attorney for the teen's mother, Carol Champommier.
The government said it was reviewing the ruling and will consider whether to file an appeal.
"The ruling does not change our position that Champommier struck an LASD deputy with his car, and Agent LoPresti reasonably used deadly force to deal with the dangerous situation," the U.S. Attorney's office said in a statement.


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"The Amazing Race" took its final three teams on a frantic scramble through Atlanta during Sunday's conclusion of the CBS competition show.
In the end, it was Ernie Halvorsen and his fiancee Cindy Chiang, both from Chicago, who crossed the finish line at Atlanta's historic Swan House to win the $1 million prize.
In second place were Californians Jeremy Cline and Sandy Draghi. In third place were former NFL player Marcus Pollard and his wife Amani, from Pine Mountain, Ga.
During this last leg of the round-the-world race, the couples were required to land a jetliner in a flight simulator, find "Gone With the Wind" author Margaret Mitchell's home, and plot their 40,000-mile odyssey on a giant world map erected high above the parking lot at Turner Field.
But interviewed after the broadcast, the winners said their most unnerving moment was the basic task of getting a cab at Atlanta's airport.
"Nobody wanted to take us," Ernie said. "That was the most stressful thing as we saw the other teams departing."
Finally a driver volunteered, "and we give him all the rest of our money as a tip," said Cindy.
The episode's most comic scene: when Jeremy and Sandy went in search of "the Dump," the name for Mitchell's famous residence, but instead were delivered by their driver to a huge department store called The Dump, where they wasted precious time prowling its aisles in vain to find the clue that wasn't there.
"This is so nerve-racking," said Draghi when they were back on the road. "I have to get on Prilosec when I get home."


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I have been after a wicker basket for quite a while. I really liked the look of the Laura Ashley Kubu Storage Trunk as it's both beautiful and practical. However I could not afford the £80 price tag so I carried on looking.....
Well look what I found for £12 at my local indoor market!
I'm really pleased, this will be very useful for storing linens and look great on top of my wardrobe (when I get round to painting the wardrobe). Plus I have saved an awful lot of money! It shows that it pays to be patient and to keep on looking.
Whilst browsing I also noticed this duck jug. How cute! I couldn't resist and he came quacking home with me and is now proudly sitting on my window sill. This was only £8 so another bargain!
It's sometimes easy to forget how good markets are. My local market has an indoor and outdoor section that sells vintage goods, as well as modern furniture, electricals, toys, clothing and food. I always find it more satisfying to buy goods from a market stall rather than a national chainstore or supermarket. In terms of food produce the chain from farm to consumer is reduced which can only be a good thing both environmentally and in terms of quality due to the stall owner having more knowledge of where the produce came from in the first place. Plus it's helping small businesses to survive in an economic environment that is incredibly tough. So if you've never been to a market, have a go as you'll find it fun and you'll be amazed at what your pennies can get you!


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Assistive Technology for Access and Participation in Typical Early Childhood Settings
PaTTAN - Online Course
Event Type: On-line Courses
Credit Type: (5 hours)
Registration Contact: Molly Martz, firstname.lastname@example.com, 800-360-7282
Content Contact: Heidi Wettlaufer, firstname.lastname@example.com, 800-446-5607
This online course provides a sequenced training on using assistive technology (AT) with young children birth to age five in order to increase their participation in typical early childhood settings. Topics covered include types of AT, evaluating functional use of AT, using AT for communication and emergent literacy and making adaptations. You will need to complete the course within a four week time period.
Participants will be able to:
Module 1: Overview of Assistive Technology
Participants will:
- Explore the legal basis for providing assistive technology (AT) to children
- Examine the types of AT used with young children
- Describe the routines, activities and environments in which AT can be used
- Identify recommended practices for using AT with young children
Module 2: Determining the need for Assistive Technology/integrating into activities
Participants will:
- Describe ways to identify how AT may assist a child
- Define universal design for all children
- Determine how to monitor whether a trial device is effective
- Examine the use of AT in existing routines and functional activities using a collaborative approach.
Module 3: Communicating using Assistive Technology
Participants will:
- Examine the types of AT used for communication
- Discuss communication message selection
- Explore integration of opportunities to communicate into existing activities in home, school, child care and community settings.
Module 4: Emergent Literacy
Participants will:
- Define research based strategies for developing literacy skills in children using AAC
- Explain the importance of developing literacy skills in children with disabilities
- Develop strategies to increase a child's ability to participate in literacy activities
Module 5: Practical Strategies
Participants will:
- Discuss switch selection and use for children who are developmentally delayed
- Explore adaptations to common play materials
- Identify devices and adaptations that allow children to access the computer
- Examine hands-on directions and activities to develop adapted materials
Target Audience
Early Intervention staff and Early Childhood teachers, and parents
Individuals attending this course must arrive on time and stay the duration of the course in order to receive Act 48 Professional Education hours. Requests for exceptions are to be brought to the attention of the individual´s Superintendent or IU Director prior to the course.
Topics Covered: Assistive Technology, Early Intervention, Parent/Family
There are no comments currently available
- You must be logged in to comment.
Please use the comments for discussion and to contribute your reviews, perspective and thoughts. Your colleagues and other visitors will appreciate it! If you need help, please contact us. Requests for help will not be answered in comments.
- Nan Rodgers
Reasonable efforts will be made to accommodate individuals who have special needs as addressed by the Americans with Disabilities Act and who need assistance at this training. Contact: name, at phone, or email.
Registration Deadline
Registration is available until the 25th of the month prior to each offering. Registration for each offering is only available in the month immediately proceeding the start date.


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I warn you-- I used four sticks of butter, 8 Tablespoons of Dutch Processed Cocoa and 1 pound of powdered sugar. This is no time to be counting calories, or fat grams.
This is the BEST chocolate sheet cake ever! I have to give most of this away, tomorrow. Otherwise, I will be looking for bigger bathing suits to wear to my water aerobics classes.
I'll tell you all about Pioneer Woman (if you don' t know her, yet) at the end of this post. I want you to stick with me, long enough to see how easy this cake is to make.
2 sticks of butter are melted with Dutch Processed Cocoa (use any kind of unsweetened); I found this stuff at Trader Joe's and I love it.
Boiling water is added to the melted butter and cocoa and then poured into the mixture of flour, sugar and salt.
A little tip-- do all the mixing in your kitchen sink. Cocoa makes a mess!
Next, buttermilk, eggs, vanilla and baking powder makes their appearance.
Whisk the batter together and get read to pour:
I love that I could use one of my commercial baking sheets, and I didn't have to grease it or prepare with parchment paper! Bake this for about 20 minutes at 350F (I underbaked for 18 minutes and it was perfect).
In the meantime, it's time to make frosting:
Chop pecans (you can omit these, which my son wish I had...but I love pecans and I was feeling selfish)
Measure your thighs and repeat the melted butter and cocoa process again. You can exercise in the morning....
Pour the melted butter and cocoa into powdered sugar and then add the pecans.
Here's another thing that makes this cake easy-- you don't have to remove it from the pan, and you don't cool it!
And I took the fastest photo shots ever.... and I dug in...and my eyes filled with tears.
OMG. I have sinned. I have met the devil on a plate.
You have to make this. If you do, I want to know if you have fallen for this recipe the way that I have.
I need chocolate detox. This will be my "secret weapon recipe" at an upcoming potluck.
Excuse me, while I go hide my bathroom scale.


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- Your selections:
Database Results for Your Selections
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Georgia Historic Books
The Georgia Historic Books database contains full-text, fully searchable books related to Georgia's history and culture. Most are from the 19th to early 20th century and focus on Georgia history, biography, and literature.Expand
The database will contain approximately 300 selected books when complete. These have been selected using bibliographies on Georgia history and in consultation with historians, librarians, and other experts on the literature and history of Georgia. The focus of the selection favors history, biography, and literature, but other subject areas related to Georgia are also included. The books may deal with Georgia history as a subject, or they may have been important for the cultural and intellectual development of the state.
In the database, to see a list of all books currently available, choose the option for "Browse by Title, Author, or Date."
Subjects: Archives and Primary Sources, English and American Literature, Georgia, History US
German Literature Collections
Brings together five individual ProQuest German literature resources: Goethes Werke, Schillers Werke, Kafkas Werke, Brechts Werke and Die Deutsche Lyrik. Each author database is searchable and contains complete works in full-text format.Expand
The Deutsche Lyrik covers German poetry from the 15th-20th-centuries, including all volumes published within Reclam's Universal-Bibliothek since 1945.
Subjects: Comparative Literature, English and American Literature
Godey`s Lady`s Book
Published from 1830 to 1898, Godey's was the most popular 19th century women's magazine. Known for its illustrations, including hand-colored fashion plates, and literary works by Harriet Beecher Stowe, Edgar Allen Poe, and other celebrated authors of the day.Expand
Part of the Accessible Archives database.
Subjects: Archives and Primary Sources, English and American Literature, History Modern 1800-, History US, Womens and Gender Studies


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|1. Ticketing Date
|2. Departure Date
|3. Blackout date
|4. Stopover
|2 stopovers in BKK, 1 in each direction
|5. Ticket validity
|2 months
|6. Penalty
|Before Departure
|- Change Reservation
|permitted free of charge in the same RBD
|- Rerouting
|Not permitted
|- Reissuing
|permitted free of charge within ticket validity
| - Refunds/ Cancellations
|After Departure
|- Change Reservation
|- Rerouting
|Not permitted
|- Reissuing
|- Refunds/Cancellations
|Partially used ticket:Not permitted
|7. Children and Infant
|Accompanied child age 2 to 11 years; discount 25 pct of the applicable adult fare
Infant under 2 years with seat - discount 25 pct of the applicable adult fare
Unaccompanied minors are not permitted on these fares.
|8. Mileage Accrual
|9. Seat per flight
|Limited seat per flight.
** This promotion cannot be used in conjunction with other promotions including all upgrades
** TG reserves the right to change fares and conditions without prior notice.


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By Doug Palmer
WASHINGTON (Reuters) - A senior Republican U.S. lawmaker on Friday urged President Barack Obama to "go big" and "go smart" in pursuit of new trade agreements in his second term in office.
Representative Kevin Brady, chairman of a key trade subcommittee in the House of Representatives, also urged Obama to seek legislation known as "Trade Promotion Authority" to facilitate the negotiation and approval of trade deals.
Republicans accuse Obama, who was re-elected to a four-year term last week, of dragging his feet on trade deals because of opposition from labor unions who are concerned that U.S. jobs would be lost.
"We need to go big. We need to go smart. But above all we need to go on trade," Brady said at an event organized by the Global Business Dialogue and the Washington law firm of McDermott Will & Emery.
Brady outlined an agenda that includes many initiatives already being pursued by the Obama administration, including a regional free trade agreement in the Asia-Pacific region and possible free trade talks with the European Union.
Beyond that, he said, "America needs to lead again on trade" through projects such as a bilateral investment treaty with China and "an honest assessment" of ways to boost trade with two other major developing countries, Brazil and India.
The call for Obama to vigorously engage on trade comes amid expectations of new leadership in 2013 at the U.S. Trade Representative's office. Current U.S. Trade Representative Ron Kirk has said he does not expect to serve a second term.
U.S. business and congressional sources say a number of Obama administration officials appear to be under consideration for the job, including White House international economic affairs advisor Michael Froman, U.S. Ambassador to the World Trade Organization Michael Punke and Deputy U.S. Trade Representative Demetrios Marantis.
Brady also urged the Obama administration, in consultation with Congress, to weigh free trade talks with additional countries such as Egypt, Turkey and Georgia.
The United States should also consider bringing additional Latin America countries into the Trans-Pacific Partnership (TPP) agreement currently being negotiated with Mexico, Peru, Chile, Canada, Australia, New Zealand, Singapore, Vietnam, Malaysia and Brunei, he said.
Brady said it was vital for conclusion of the TPP that the White House has TPA, which would allow it to submit trade deals to Congress for a straight yes-or-no vote without any amendments.
The legislation, which expired in June 2007, is generally considered essential to ensure that other countries put their best offers on the table in trade talks with the United States.
"I think it's important that we move on TPA next year. Every president needs to have negotiating authority," Brady said.
Congress and the Obama administration are currently focused on negotiations to avert the "fiscal cliff," a package of tax hikes and spending cuts that are set to be triggered at the beginning of 2013.
Obama, during his first four years in office, did not ask for TPA. Brady said the time is right now for the White House and lawmakers to start talks on the topic.
Brady also said he is open to the Obama administration's idea of reorganizing government trade agencies to help companies increase export sales and create jobs.
But he said he did not support burying the USTR inside a large government bureaucracy, as the White House plan proposes.
"We ought to be cautious not to turn a nimble cheetah into a lumbering rhinoceros," Brady said of the USTR.
(Editing by Will Dunham and Paul Simao)


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nalor We are 25/ f, looking for a third person to join our June 1st-August 1st (maybe longer) trip in South America. Countries of interest include but are not limited to: Peru, Bolivia, Chile, Argentina, Brazil Goals include: to be in nature, to camp as much as possible, to have a good time, to live modestly while pinching pennies, to meet some good people, to speak in Spanish, to not over plan and to make the best of any and all situations that may arise Boy scouts encouraged to apply.
6 years ago


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text:
First Ski School in AmericaMay 23. 2013 4:10PM
Junction of Route 117 and Lover's Lane Road
Sugar Hill, NH
Marker Number: 73
Name and date established: Sugar Hill 1971
Description: In 1929, on the slopes of the hill to the east, Austrian-born Sig Buchmayr established the first organized ski school in the United States. Sponsored by Peckett's-on-Sugar-Hill, one of the earliest resorts to promote the joys of winter vacationing in the snow, the school provided an initial impetus to the ski sport America knows today.
Location: Located at the junction of Route 117 and Lover's Lane Road, about five miles south of the junction of Routes 117 and 118.
* e-Edition subscription required


text:
SALT LAKE CITY — When the 2014 Legislature begins meeting Monday, lawmakers will face a pressure familiar to Utah families: trying to make sure there's enough money to keep up with expenses.
While revenues are up, there's increasing pressure to look at raising taxes for transportation and education. But legislative leaders say there's little chance tax hikes will be approved during the 45-day session.
This is an election year for most lawmakers, and other issues are expected to surface, particularly dealing with religious freedom and potential antidiscrimination legislation.
The Legislature will address other key issues, including the Wasatch Front's poor air quality, the state's liquor laws, early education, college readiness and intergenerational poverty, each an issue of importance for Utah's families.
Gov. Gary Herbert, whose $13.3 billion budget does not contain any tax increases, expressed frustration over the lack of urgency to deal with transportation funding this session.
"I understand politics, and usually gasoline taxes have historically been done in an off-election year. But we need to have the discussion as far as how we're going to pay for the billions of dollars of needs in infrastructure and roads going forward," Herbert said.
Even the governor acknowledged that it may take time to come up with either a way of tying the first increase in the 24.5-cent gas tax since 1997 to inflation or an alternative fee for drivers.
"I think between now and the next session, there will probably be a serious attempt to modify the gas tax or find a funding mechanism," Herbert said. "I'm anxious to hear any and all proposals."
House Speaker Becky Lockhart, R-Provo, said there could be some action this session on how the gas tax is distributed among government entities, but any change would have to be revenue-neutral.
"It's really difficult to see any increase implemented," Lockhart said. The speaker said she expects most of the discussion about transportation funding to take place during the legislative interim session.
Senate President Wayne Niederhauser, R-Sandy, said he doesn't expect any proposal to increase the gas tax to even come up for a vote, let alone pass this session.
"It can wait a year. It's just every year you decide not to do it, the harder it gets. The cure becomes more extreme and more difficult," Niederhauser said, as revenues decline because more vehicles on the road use less or even no gas.
But the Senate leader acknowledged it's a tough decision for lawmakers seeking re-election this year. "I don't think anybody wants to be pegged with increasing revenues," he said.
Money for schools?
Democrats are going to try again this session to bring in more income tax dollars for schools. Senate Minority Assistant Whip Pat Jones, D-Holladay, is looking at limiting income tax exemptions for individuals and their dependents.
"Utah voters support tax increases to pay for education," House Minority Whip Tim Cosgrove, D-Murray, said.
Only 15 percent of Utah voters polled recently for Weber State University and the Exoro Group said they would not be willing to give up an income tax exemption to increase school funding.
Niederhauser said any attempt to collect more income taxes faces an uphill battle. He said that's the reason Jones is looking at reducing exemptions rather than simply raising tax rates, "which would be dead on arrival."
His solution for finding more money for schools is raising the gas tax to free some of the general fund revenues now being steered into road maintenance and construction.
"If we want to be competitive economically, we can't be out raising the income tax," the Senate president said. "If we solve the general fund problem, we can get quite a bit more for education."
Herbert and lawmakers have agreed the state should expect $338 million more in revenues in the budget year that begins July 1, including $132 million left over from the current budget year.
But there's already a long list of needs next session, including $64 million for the 10,300 new public school students anticipated next year, a proposed addition to the state prison at Gunnison, and addressing air quality.
Add in boosts in spending to maintain ongoing efforts such as the governor's goal of ensuring 66 percent of Utah's adults having advanced degrees by 2020, and much of the new money is gone.
"This is the new normal unfortunately," the House speaker said. "It feels like we're coasting."
The forecasted 3.8 percent increase in revenue over the next budget year may be positive, but economic growth is being hampered by the federal government's regulatory policies, Lockhart said.
She said state lawmakers may have no control over what Washington does, but they can avoid raising taxes to bring in more cash by trying "to find new and more innovative ways to leverage the revenue we do have."
That includes relying more on technology in the classroom, the speaker said. House Republicans are "looking very seriously" at legislation to ready educators to shift away from paper and textbooks, she said.
Mounting costs
Lawmakers also have to tackle mounting expenses from the House's special investigation into former Attorney General John Swallow that could reach as much as $4 million or more.
There's also the costs of defending Amendment 3 to the state constitution after a federal judge struck down the amendment in December, and mounting a defense against a new lawsuit over recognition of same-sex couples who married before a stay in the case was issued.
None of those items were anticipated when lawmakers put together the state's current budget a year ago, but legislative leaders said they have no choice but to find the money.
"Afford it or not, we've got the bill," the Senate president said of the Swallow investigation costs. The House committee is expected to wrap up its work during the session.
Niederhauser was more enthusiastic about picking up the tab for defending the state's voter-approved constitutional definition of marriage as between a man and a woman, struck down last month by a federal judge.
While new Attorney General Sean Reyes had told lawmakers it could cost as much as $2 million for outside counsel to take the case to the U.S. Supreme Court, he announced recently the attorneys involved agreed to cap their fees.
"The Senate is very supportive of us defending our jurisdiction over marriage, so we feel like this is our duty to see this through," Niederhauser said. "The people have spoken. It's in our constitution."
The House speaker said the Swallow investigation price tag was not out of line with the House's expectations, and she praised the attorney general for keeping the costs down in the Amendment 3 case.
Lockhart said the state's appeal of the case may mean legislation won't go forward on related issues including the preservation of religious freedom and a statewide ban on housing and employment discrimination against the lesbian, gay, bisexual and transgender community.
"We're still evaluating what the best course of action is. And the best course of action may be to do nothing. And I'm OK with that," the speaker said. "The answer may be stand down. Let's let this run its course in the courts."
Medicaid expansion
There will be a plan to expand Medicaid coverage this session, the governor said. He announced last week he had ruled out "doing nothing" about the extension available under the Affordable Care Act, but he wasn't ready to provide details.
While the federal government will pick up the initial costs of the expansion, Lockhart has called for the state to start setting aside now whatever funds would be needed in the future.
Herbert said such a fund is a possibility, but there are many ways to handle the expansion.
"In the next 45 days, we'll have a decision," the governor said. "We just want to make sure we're not doing something that will come back and bite us in the behind."
Email: [email protected]
Twitter: DNewsPolitics


text:
Managed by Jonathan Tinn, the USA distributor of DarTZeel, a Swiss electronics company that makes amplifiers and preamplifiers. This is the forum to discuss, ask questions and review DarTZeel products.
Use this control to limit the display of threads to those newer than the specified time frame.
Allows you to choose the data by which the thread list will be sorted.
Order threads in...
Note: when sorting by date, 'descending order' will show the newest results first.
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text:
hi..can sum1 help me wid smartftp..whenever i try a connection it shows the error mssg ' A socket operation was attempted to an unreachable host'..plz help..
Hi there, welcome to Ao
The way this site works my friend is everything is broken down into different forums. When you want to post a thread select the correct forum that best suits your needs and post there. That way the people who know that subject best will be looking in that forum and you will get an answer quicker and probable a more helpful one too! General Chit Chat aint the place for this!
But since its here, it says the host(computer/site etc) you are trying to connect to is unreachable. Amongst other reasons this could be because it is not there, will not accept connections from you or has a firewall running to block connections. Or you could be typing the address in wrong.
What is it you are trying to connect to?Try and include as much info as possible.
//Dont double post, I will PM a mod for you and ask if they can move this.
Drugs have taught an entire generation of kids the metric system.
Forum Rules


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Steve Granitz/WireImage
It's a boy!
Ali Landry and her husband, director Alejandro Monteverde, welcomed son Marcelo Alejandro on Saturday, Oct. 8 in Los Angeles, the actress's rep tells PEOPLE exclusively.
Baby boy was born at 5:40 p.m. and weighed in at 8 lbs. and 21 inches long.
Shortly after announcing her pregnancy, the former Doritos spokeswoman, 38, told PEOPLE that she was using grilled cheese sandwiches to battle morning sickness.
Landry and Monteverde, 34, also have a daughter, 4-year-old Estela Ines.
— Liz Raftery and Jennifer Garcia


text:
Wellington, Florida, United States
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I create unique and colorful personalized birthday invitations, shower invitations, baby announcements, and diy party printables. I can easily make custom designs too, just ask me. I am dedicated to 100% customers satisfaction. I work fast and make edits until your product is absolutely perfect! I hope you will find exactly what you need to make your party fabulous.


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Government wants 12% of public servants working from home
REGIONAL Australia could be the big winner from a Federal Government push to have more people working from home.
Prime Minister Julia Gillard announced on Monday the government was committed to having 12% of Australian public servants working from home within eight years.
She announced the target, an 8% increase on the current number, on Monday to launch National Telework Week.
The government obviously sees telework as the perfect vehicle to promote the benefits of the National Broadband Network, which is being rolled out around the country at a cost of close to $40 billion.
Telework, which Ms Gillard described as a "big part of the future of work in Australia", is a flexible work arrangement where employees are able to work from home or other locations away from the office, using broadband and digital technology.
Ms Gillard also used the launch to reveal the findings of research by Colmar Brunton and Deloitte Access Economics, which found teleworking could create the equivalent of an additional 25,000 full-time jobs, including 10,000 in regional Australia, by 2020-21, as well as boosting annual GDP by $3.2 billion.
The researchers also found 70% of people living in regional and remote parts of Australia not currently employed would take up telework if it was available to them.
Ms Gillard said Australia, and regional areas in particular, were in a "dynamic time of change".
She cited examples of the way technology was already being harnessed outside the cities.
"Based in regional Australia, a clothing story that saturated its own market in its regional town and now trades around the nation and around the world," Ms Gillard told the Telework Congress in Melbourne via videolink from Canberra.
"These are the kind of things that we wouldn't have imagined as job possibilities in regional Australia five, 10, 15 years ago but are there now for people to get those jobs and get that work and have that highly skilled work in regional Australia. We can't see all of these future possibilities but we certainly can get ready for them."
And she did not miss the opportunity to spruik the benefits of the NBN, which she said would make working from home increasingly viable and allow people to stay in regional areas without harming their careers.
"The NBN will help unlock the potential of telework to boost productivity in the workplace, reduce commuting time and urban congestion and allow employers to compete for the best employees, no matter where they are located," Ms Gillard said.
The Prime Minister said companies such as Cisco, Telstra, Westpac, Medibank Health Solutions, Microsoft and KPMG were already using telework to retain and attract skilled staff and make cost savings by reducing pressure on office accommodation.
The inaugural National Telework Week runs until Friday, with more than 130 companies and organisations having committed to the week as official partners.
A series of teleworking trials will begin in the first half of next year across a number of Australian Public Service departments.
Research by Colmar Brunton and Deloitte Access Economics found:
- 66% of people with disabilities who are not in the labour force would take up telework if it was available to them;
- 74% of people with family or carer responsibilities who are not in the labour force would take up telework if it was available to them;
- 60% of people nearing retirement age would take up telework if it was available to them, and;
- 70% of people living in regional/remote Australia who are not in the labour force would take up telework if it was available to them.


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LOS ANGELES, CA AND CAMBRIDGE, UK – July 23, 2003 – ARM [(LSE:ARM); (Nasdaq:ARMHY)], the industry's leading provider of 16/32-bit embedded RISC processor solutions, and Innovics Wireless Inc., today announced that Innovics has licensed the ™ microprocessor core. Focused on developing solutions for 2.5G and 3G wireless terminals, Innovics will use the ARM922T core in its range of baseband signal processors which will increase the capacity of wireless network cells by between two and four times.
In existing 2.5G or 3G network cells, there is typically more download data traffic than upload traffic, requiring base station transmitters to work harder and use more power in order to support quality of service demands. Until now, the solution to this problem has been to add more base station cells. Innovics has developed unique Diversity Processing technology that helps alleviate this power and quality of service problem.
"As we move through service generations into the 3G domain, we will see a proliferation of data intensive services which will put huge demands on the networks that carry them," said Tom Willey, president and CEO, Innovics Wireless Inc. "Not only is it important to develop base station technology, it is also the responsibility of wireless terminal developers to play their part. Innovics technology will play a critical role in maintaining and improving quality of service on these networks and the ARM922T core will provide us with an excellent platform around which we can build our leading baseband solutions."
Innovics' technology-enabled wireless terminals utilize two antennas to combine two sets of data signals to get the best possible signal which enables faster processing at the terminal, thus requiring no modifications to the base station or network infrastructure. With its excellent low power and high-performance credentials, the ARM922T core will play an important role in enabling Innovics to continue its development of power and performance sensitive baseband devices.
"The ARM922T microprocessor core is ideally suited to a range of wireless devices including terminal technology," said John Rayfield, VP of US Marketing, ARM. "To date, more than a dozen Partners have licensed the core for use in a range of wireless applications, testament to the core's ability to fulfil the low power and high performance requirements of such solutions. Innovics' use of the ARM922T core in its baseband products will prove a valuable contribution to the roll out of 3G networks."
Innovics will gain access to the ARM922T core via the ARM® Foundry Program. The Foundry Program offers a flexible partnership model that accelerates the time-to-market for ARM core-based designs, and enables companies which do not have access to fabrication facilities to work directly with an approved ARM semiconductor foundry, thus building a three-way Partnership between ARM, an approved silicon foundry, and Innovics.
About Innovics Wireless
Innovics Wireless Inc. is a semiconductor company with strong expertise in wireless communications. Founded in 2000, Innovics is a privately held semiconductor company located in West Los Angeles, California. The company is focused on providing advanced baseband signal processing solutions to the emerging 2.5G and 3G cellular markets. The company supplies integrated circuits and licenses semiconductor intellectual property cores that deliver unprecedented improvements in data transmission to the wireless handset.
Innovics Wireless is committed to providing its customers with a complete solution with enhanced capabilities that enable high-speed data communications under the most demanding of channel and environmental conditions. This is achieved purely at the mobile terminal and does not require any modifications to the base station and infrastructure. The company's patented architecture provides a standard independent platform that can be applied to any one of the existing or emerging 2.5G and 3G cellular systems.
About ARM
ARM is the industry's leading provider of 16/32-bit embedded RISC microprocessor solutions. The company licenses its high-performance, low-cost, power-efficient RISC processors, peripherals, and system-chip designs to leading international electronics companies. ARM also provides comprehensive support required in developing a complete system. ARM's microprocessor cores are rapidly becoming a volume RISC standard in markets such as portable communications, hand-held computing, multimedia digital consumer and embedded solutions.


text:
Legal Status
Document Details
Published Document
Office of the Acting Deputy Under Secretary for Food Safety, USDA.
Notice of public meeting and request for comments.
The Office of the Acting Deputy Under Secretary for Food Safety, U.S. Department of Agriculture (USDA), and the U.S. Food and Drug Administration (FDA), Center for Veterinary Medicine, are sponsoring a public meeting on April 29, 2009. The objective of the public meeting is to provide information and receive public comments on agenda items and draft U.S. positions that will be discussed at the 18th Session of the Codex Committee on Residues of Veterinary Drugs in Foods (CCRVDF) which will be held in Natal, Brazil from May 11-15, 2009. The Acting Deputy Under Secretary for Food Safety and the FDA recognize the importance of providing interested parties the opportunity to obtain background information on the 18th CCRVDF session and to address items on the agenda.
The public meeting is scheduled for Wednesday, April 29, 2009, from 10 a.m.-1 p.m.
The public meeting will be held at the USDA, J.L. Whitten Building, Room 107-A, 1400 Independence Avenue, SW., Washington, DC 20250.
Documents related to the 18th session of the CCRVDF will be accessible via the World Wide Web at the following address: http://www.codexalimentarius.net/current.asp.
The U.S. Delegate to the 18th Session of the CCRVDF, Dr. Steven Vaughn, and the FDA invite U.S. interested parties to submit their comments electronically to the following e-mail address: firstname.lastname@example.com.
For Further Information About the 18th Session of the CCRVDF Contact: Steven Vaughn, D.V.M., Director, Office of New Animal Drug Evaluation, Center for Veterinary Medicine, FDA, 7500 Standish Place, Rockville, MD 20855 Telephone: (240) 276-8300, Fax: (240) 276-8242, e-mail: email@example.com.
For Further Information About the Public Meeting Contact: Jasmine Matthews, Program Analyst, USDA, Food Safety and Inspection Service, U.S. Codex Office, 1400 Independence Avenue, SW., Room 4861, Washington, DC 20250. Telephone: (202) 690-1124, Fax: (202) 720-3157, e-mail: email@example.com Preamble Start Supplemental Information
The Codex Alimentarius (Codex) was established in 1963 by two United Nations organizations, the Food and Agriculture Organization (FAO) and the World Health Organization (WHO.) Through adoption of food standards, codes of practice, and other guidelines developed by its committees, and by promoting their adoption and implementation by governments, Codex seeks to protect the health of consumers and ensure that fair practices are used in trade.
The CCRVDF is responsible for determining priorities for the consideration of residues of veterinary drugs in foods; to recommend maximum levels of such substances; to develop codes of practice as may be required; and to consider methods of sampling and analysis for the determination of veterinary drug residues in foods.
The Committee is hosted by the United States.
Issues To Be Discussed at the Public Meeting
The following items on the agenda for the 18th Session of the CCRVDF will be discussed during the public meeting:
- Matters Referred by the Codex Alimentarius Commission and Other Codex Committees and Task Forces.
- Matters Arising from FAO and WHO and from the 70th Meeting of the Joint FAO and WHO Expert Committee on Food Additives (JECFA).
- Report of the World Organization for Animal Health (OIE) Activities, Including the Harmonization of Technical Requirements for Registration of Veterinary Medicinal Products.
- Draft Maximum Residue Limits (MRLs) for Veterinary Drugs (at Step 7).
- Proposed draft MRLs for Veterinary Drugs (at Step 3).
- Draft Guidelines for the Design and Implementation of National Regulatory Food Safety Assurance Programs Associated with the Use of Veterinary Drugs in Food Producing Animals.
- Discussion Paper on Consideration of Methods of Analysis and Sampling in the CCRVDF (Report of the Electronic Working Group on Methods of Analysis and Sampling).
- Draft Priority List of Veterinary Drugs Requiring Evaluation or Re-Evaluation by JECFA and the Working Document Listing Veterinary Drugs of Potential Interest (Report of the Electronic Working Group on the Priority List of Veterinary Drugs Requiring Evaluation or Re-evaluation).
- Discussion Paper on Current Practices and Needs for Further Work by the Committee (Report of the Electronic Working Group on Risk Management Topics and Options).
Each issue listed will be fully described in documents distributed, or to be distributed, by the Secretariat prior to the meeting. Members of the public may access copies of these documents (see ADDRESSES).
Public Meeting
At the April 29, 2009, public meeting, draft U.S. positions on the agenda items will be described and discussed, and attendees will have the opportunity to pose questions and offer comments. Written comments may be offered at the meeting or sent to the U.S. Delegate for the 18th Session of the CCRVDF, Dr. Steven Vaughn (see ADDRESSES). Written comments should state that they relate to activities of the 18th session of the CCRVDF.
Additional Public Notification
Public awareness of all segments of rulemaking and policy development is important. Consequently, in an effort to ensure that minorities, women, and persons with disabilities are aware of this notice, FSIS will announce it online through the FSIS Web page located at http://www.fsis.usda.gov/regulations/2009_Notices_Index/. FSIS will also make copies of this Federal Register publication available through the FSIS Constituent Update, which is used to provide information regarding FSIS policies, procedures, regulations, Federal Register notices, FSIS public meetings, and other types of information that could affect or would be of interest to constituents and stakeholders. The Update is communicated via Listserv, a free electronic mail subscription service for industry, trade groups, consumer interest groups, health professionals, and other individuals who have asked to be included. The Update is also available on the FSIS Web page. Through the Listserv and Web page, FSIS is able to provide information to a much broader and more diverse audience. In addition, FSIS offers an electronic mail subscription service which provides automatic and Start Printed Page 16354customized access to selected food safety news and information. This service is available at http://www.fsis.usda.gov/news_and_events/e-mail_subscription/. Options range from recalls to export information to regulations, directives and notices. Customers can add or delete subscriptions themselves, and have the option to password protect their accounts.Start Signature
Done at Washington, DC on: April 6, 2009.
Paulo Almeida,
Acting U.S. Manager for Codex Alimentarius.
[FR Doc. E9-8181 Filed 4-9-09; 8:45 am]


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FORT COLLINS, Colo.--(BUSINESS WIRE)--VetDC, Inc., a veterinary cancer therapeutics company, today announced that the Company has received three major technical section complete letters for TanoveaTM (rabacfosadine) from the U.S. Food and Drug Administration's Center for Veterinary Medicine (FDA-CVM). Upon approval, Tanovea will be the first on-label therapeutic option for use in dogs with lymphoma, one of the most common cancers afflicting companion animals today.

 The three major technical section complete letters are required to file an administrative New Animal Drug Application for approval with the FDA-CVM. VetDC plans to submit the administrative filing later this year. Once Tanovea receives FDA approval, VetDC intends to commence commercialization in early 2017.

 "This is a significant milestone for VetDC, as we are one step closer to introducing the first FDA-approved drug for use in dogs with lymphoma," stated Steven Roy, VetDC's President and CEO. "There is a clear unmet need for new therapeutic alternatives to address this common and devastating cancer in pets. Given Tanovea's demonstrated anti-tumor effects, rapid onset of action, generally well–tolerated profile and a substantial reduction in pet owner visits to the veterinarian, our market research suggests that Tanovea has the potential to achieve peak sales of at least $40 million annually in a rapidly growing market."

 About Tanovea

 TanoveaTM (rabacfosadine) is a novel small molecule drug designed to preferentially target and attack cancer cells implicated in lymphoma, one of the most common and deadly cancers impacting pets today. In multiple clinical studies in over 300 client-owned dogs with naturally occurring lymphoma, Tanovea has consistently demonstrated substantial anti-tumor activity in both naïve and relapsed cases, with a generally well-tolerated safety profile. Tanovea has a rapid onset of action, with responses observed in as few as 7 to 21 days. Tanovea is being investigated as a convenient, every-three-week treatment for up to five doses, representing a substantial reduction in client visits relative to non-approved 'human' generic chemotherapy regimens commonly utilized in dogs.

 VetDC has an exclusive North American license from Gilead Sciences to develop and commercialize Tanovea for companion animal cancer.

 About VetDC, Inc.

 VetDC (www.vetdc.com) is changing the way new cancer medicines are developed for companion animals, leveraging novel advancements from human biotechnology that have demonstrated success in animal studies. VetDC currently has two programs in development, Tanovea for lymphoma and VDC-597 for multiple cancers.

Contacts

 VetDC
Steven Roy, 303-859-2072

 - Includes Clinical Data from the Phase 2a Influenza Virus Challenge Study of VIS410 and Preclinical Data that Demonstrated VIS410 Does Not Cause Antibody-Dependent Enhancement -

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Visterra, Inc., a clinical-stage biotechnology company, today announced that two posters and one oral presentation related to the Company's lead product candidate, VIS410, a novel monoclonal antibody in development for the treatment of seasonal and pandemic influenza A, will be presented at the Options IX for the Control of Influenza Conference in Chicago, Illinois, on August 24 – 28, 2016.

 The data presented at the Options IX Conference will detail efficacy, resistance testing, and pharmacokinetic results from a Phase 2a influenza viral challenge study of VIS410. Data also will be presented that demonstrates that, in preclinical mouse models, VIS410 did not cause antibody-dependent enhancement, which is a phenomena where non-neutralizing antibodies can bind to the virus and enhance the disease.

 "We look forward to sharing these encouraging clinical and preclinical data on VIS410 at this important international meeting of leaders in the influenza field," said José Trevejo, MD, PhD, Vice President of Development of Visterra. "We are very pleased by the results of our Phase 2a influenza viral challenge study, which we believe support the continued development of VIS410 as a single administration treatment for hospitalized patients with influenza A infection. Furthermore, our clinical progress to date with VIS410 demonstrates the potential value of our innovative drug discovery and development platform and its ability to create novel therapeutic candidates aimed at meeting important unmet medical needs."

 The Options for the Control of Influenza Conference is held every three years and is the largest international scientific conference exclusively devoted to influenza. The VIS410 data presentations at the Options IX Conference are as follows:

 Poster Number P-33: Pharmacokinetics of the Hemagglutinin (HA) Stalk-Binding Antibody, VIS410, in a Human Challenge Model of Infection with a p2009 H1N1 Virus
Date: Thursday, August 25, 2016
Location: Exhibit Hall A & B, Sheraton Grand Chicago Hotel
Viewing Time: 10:30 am – 12:30 pm; 3:30 pm – 7:30 pm
Presentation Time: 6:00 pm – 7:30 pm

 Poster Number P-422: Treatment with a Hemagglutinin (HA) Stem-binding Monoclonal Antibody, VIS410, Does not Cause Antibody Dependent Enhancement (ADE) in Preclinical Models of Influenza A Virus Infection
Date: Friday, August 26, 2016
Location: Exhibit Hall A & B, Sheraton Grand Chicago Hotel
Viewing Time: 10:30 am – 12:30 pm; 3:30 pm – 7:30 pm
Presentation Time: 6:00 pm – 7:30 pm

 Oral Presentation Title: Evaluation of Efficacy and Emergence of Resistance to VIS410, a Human Monoclonal Antibody, in a Human Challenge Model of Infection with a p2009 H1N1 Virus
Publication Number: O-71
Date: Saturday, August 27, 2016
Session: Oral Abstract Session: Clinical Science
Session Time: 11:00 am – 12:30 pm
Presentation Time: 11:15 am

 About VIS410
VIS410 is a monoclonal antibody that Visterra is developing as a single-dose administration for the treatment of hospitalized patients with influenza A, regardless of the viral strain. Visterra is planning to advance VIS410 into additional clinical trials in patients with influenza A to further evaluate efficacy and safety. Visterra believes that VIS410 has the potential to effectively treat severe disease caused by all strains of influenza A, including those caused by mutated and recently emerged strains. VIS410 is directed against a Hierotope on hemagglutinin, which is a surface protein of influenza viruses used for binding and entry into cells. VIS410 is designed to prevent fusion of the virus cell membrane with the membrane of infected cells by binding to hemagglutinin and thereby terminating the viral replication cycle.

 About Influenza
Influenza is an infectious disease that causes illness in humans worldwide with symptoms that range in severity from mild to life-threatening. The majority of seasonal influenza infections result in mild illness; however, some infections result in severe disease, which can involve rapidly progressive pneumonia, respiratory failure and, in some cases, death. Severe disease is more commonly observed in high-risk groups, including infants, pregnant women, the elderly, patients with underlying medical conditions, and patients with disease- or treatment-related immunosuppression. According to the CDC, approximately 35 million people suffer from influenza infections in the United States each year, resulting in as many as 400,000 hospitalizations and as many as 49,000 deaths. The World Health Organization reports that globally there are as many as five million severe influenza cases annually, leading to as many as 500,000 deaths. In addition to seasonal infections, epidemics that spread across countries and continents, or pandemics, are caused by influenza strains that have high rates of human-to-human transmission and, if the strain causes severe disease, can lead to a high mortality rate. Evolving avian influenza viruses (bird flu), such as H5N1 and H7N9, which have a high associated mortality rate and the potential to infect and readily transmit in humans, pose a major health risk. The avian H7N9 influenza strains that emerged in 2013 have mortality rates as high as 42% in infected individuals.

 About Visterra
Visterra is a clinical-stage biopharmaceutical company that uses its novel Hierotope™ platform to identify unique disease targets and to design and engineer innovative antibody-based therapies. Visterra's technology enables the design and engineering of product candidates which target a specific region of an antigen, or Hierotope, on a pathogen that is common across all strains of the pathogen and is resistant to mutation. The company believes these Hierotopes are critical to the structural and functional integrity of the pathogen, making them highly attractive therapeutic targets. The company is currently focused on developing therapeutics for infectious and non-infectious diseases and its lead product candidate, VIS410, is a human monoclonal antibody being developed for the treatment of hospitalized patients with influenza A, regardless of viral strain. The company's second product candidate, VIS513, is a human monoclonal antibody for the treatment of dengue that has been shown in preclinical studies to be effective against all four serotypes of the dengue virus. Visterra was founded on the research into the fundamentals of viral evolution and epitope characterization by our scientific founder, Dr. Ram Sasisekharan at MIT. For more information, please visit www.visterrainc.com.

Contacts

 Media contact:
The Yates Network
Barbara Yates, 781-258-6153

 Biothera's Imprime PGG and Merck's anti-PD-1 inhibitor KEYTRUDA® (pembrolizumab) to be evaluated in combination for patients with either advanced melanoma or metastatic triple negative breast cancer (TNBC)

 Under previous agreement, Big Ten Cancer Research Consortium (BTCRC) plans to initiate a Phase 1b/2 Imprime PGG/KEYTRUDA trial in patients with non-small cell lung cancer (NSCLC)

EAGAN, Minn.--(BUSINESS WIRE)--#Biothera--Biothera Pharmaceuticals, Inc. today announced a collaboration with Merck, known as MSD outside the United States and Canada, to expand the companies' ongoing clinical program evaluating KEYTRUDA® (pembrolizumab), Merck's anti-PD-1 inhibitor, in combination with Biothera's Imprime PGG, a Pathogen Associated Molecular Patterning molecule, or PAMP. Imprime PGG acts as an immunological "ignition switch" enlisting the innate immune system to enhance the therapeutic efficacy of tumor targeting, anti-angiogenic, and immune checkpoint inhibitor antibodies.

 Under this new collaboration, a Phase 2 clinical trial is anticipated to enroll up to 95 patients who have either advanced melanoma no longer responding to initial treatment with a checkpoint inhibitor therapy or TNBC whose disease has progressed following treatment with one or more lines of therapy for metastatic disease. Biothera will be the sponsor of the study, which is planned to begin in the fourth quarter of 2016. Merck will provide clinical supplies of KEYTRUDA for the planned studies. Other terms of the collaboration were not disclosed.

 Biothera previously announced an agreement in December 2015 for Merck to supply KEYTRUDA for a Phase 1b/2 clinical study testing combination therapy with Imprime PGG in NSCLC patients. The Big Ten Cancer Research Consortium will conduct the multi-center trial, which is expected to commence this fall.

 Barry Labinger, Chief Executive Officer of Biothera, stated, "Combination therapies with breakthrough medicines such as KEYTRUDA are potentially the next major advance in the treatment of cancer. We believe that Imprime PGG is uniquely suited to complement immune checkpoint inhibitor therapy and meaningfully enhance patient outcomes. The trial will assess safety and efficacy, as well as provide biomarker and pharmacodynamic data that will inform the design of potential Phase 3 pivotal studies."

 Eric Rubin, M.D., Vice President and Therapeutic Area Head, Oncology Early-stage Development, Merck Research Laboratories, commented, "As a leading innovator in the field of immuno-oncology, Merck is dedicated to advancing breakthrough science by continuing to identify novel combinations with potential to improve the care for people with cancer. We are pleased to expand our partnership with Biothera as we explore the potential for combining KEYTRUDA with their lead candidate."

 About Biothera Pharmaceuticals, Inc.
Biothera Pharmaceuticals is a privately held biotechnology company developing Imprime PGG, a first-in-class, mid-clinical stage cancer immunotherapy that orchestrates an integrated anti-cancer immune response in combination with checkpoint inhibitors and tumor-targeting and anti-angiogenesis monoclonal antibodies. Imprime PGG has been well-tolerated in trials in over 400 subjects and has established proof of concept in multiple clinical studies, including single-arm and randomized phase 2 studies in NSCLC, colorectal cancer, and chronic lymphocytic leukemia.

 KEYTRUDA® is a registered trademark of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.

Contacts

 Biothera Pharmaceuticals, Inc.
David Walsh, 651-256-4606
SVP Communications
firstname.lastname@example.com


text:
Thanks to Nissan for finding the story via LA Times:
The Dodgers today acquired veteran pitcher Greg Maddux in a trade with the San Diego Padres, according to a person familiar with the deal, speaking on condition of anonymity because the deal had not been announced.
It was not immediately known who was sent to San Diego in exchange for Maddux, a future Hall of Famer who is 6-9 this season with a 3.99 earned-run average.
I'll keep this updated as news breaks.
Edited by SaintNicholasVanExel, August 18, 2008 - 05:00 PM.


text:
USD Students Develop Clean Water to Go
This event occurred in the past
Thursday, April 10, 2014
U-T San Diego -- In the aftermath of disaster, clean water is first on the list of necessities. So a group of University of San Diego engineering students are building a portable water purification system that can run on solar or human power.
The project will be on display at the university's 24th annual Undergraduate Research Conference on Thursday, April 10.
The portable water purifier was proposed by five engineering students, who tailored it for use by relief agencies in events such as last year's Philippine typhoon. (Full Story)


text:
Spurred by 9/11, Willrich explored individual and collective rights
The vehicle: An early 20th century smallpox epidemic. The result: An award-winning book.
As with many Americans, the balance between individual and collective rights occupied Michael Willrich's mind in the aftermath of Sept. 11.
In that period of unease and uncertainty, there was also a renewed fear that the smallpox virus – which has been eradicated in the United States since 1949 – could become a primary weapon of biological warfare against the U.S.
From amidst those converging concerns, Willrich, a Brandeis professor of history since 2000, drew inspiration for his latest award-winning book, "Pox: An American History," which traces the smallpox epidemic at the turn of the 20th century and the country's reaction to efforts to control it. The book won critical praise and earned him honors from professional groups like the Organization of American Historians and publications like the New Yorker.
"I was sort of preoccupied, as many Americans were, with the age-old tension between individual liberty and collective interest," he recalls, "especially in the rise of a more powerful security apparatus in the United States."
"Pox," focuses on late 1890s and early 1900s, when a smallpox epidemic swept the United States and threatened public health. The disease spread quickly. Panicked government officials quarantined those suspected of it, and ordered mandatory vaccinations for the population at large. Many ordinary Americans rejected state governments' claims to have the right to order vaccinations and Willrich recounts scenarios in which citizens were held down, handcuffed or even vaccinated at gunpoint. The civil liberties battle that ensued between the officials and the anti-vaccination contingent drew him into the story, he says.
"There was a surprising amount of resistance from workers, parents, religious groups," in large part due to the lack of vaccine regulation that Americans now take for granted. Cases of illness and death were reported in people who had been vaccinated.
"One of the challenges in writing this was to think about and be able to talk about the history of science and medicine in a way that is aware of what we know now, but with an appreciation for what we knew then," Willrich says. "I wanted to draw analysis without doing an injustice to the fact that public health officials on the ground in 1901 had to fight the disease with the knowledge at their disposal."
Willrich, who earned a bachelor's degree in history from Yale and master's and doctoral degrees from the University of Chicago, says he's interested in the way ordinary people interact with the law.
He previously taught at Rice University, but said Brandeis was "very much on my mental map," having been a student and colleague of various Brandeis history program alumni.
His expertise is in urban, legal and, now, medical history, though he never attended law or medical schools.
"I'm largely self-taught," Willrich says, adding that he had assistance from friends and experts in the medical field. "I have a deep respect for the field – it's technical but deeply fascinating."
Willrich previously authored "City of Courts: Socializing Justice in Progressive Era Chicago." He says he did much of the research for the second book in 2003, as a Radcliffe Institute for Advanced Study fellow at Harvard University.
It wasn't until 2007, when he took on a Charles A. Ryskamp Research Fellowship at the American Council of Learned Societies, that he began writing it.
Willrich has taught a variety of courses at Brandeis, including the two-semester "History of Legal Studies," "Crime and Punishment in History" and "America in the Progressive Era." In the fall, he'll teach "Introduction to Doctoral Studies."
Before pursuing his graduate degrees, Willrich worked as a journalist in Washington, D.C., writing for The New Republic and Washington Monthly, among other publications. But he says teaching and writing history were always on his radar. Taking a cue from his father, who at one time was a writer and law professor, he says he liked what he "imagined that lifestyle to be." Not only was the diversity of skills attractive, but he also enjoyed seeing the way his father got to interact with students, and the time he had to spend with family in the summer.
In that sense it's no surprise Willrich has focused on building relationships with his own students. In 2011, he received the Dean's Award for Outstanding Mentoring of Students in the Graduate School of Arts and Sciences.
The two processes – teaching and writing – reinforce each other, Willrich says. His research informed the reading he assigned his students, adding more depth to discussions of public health and civil liberties. Likewise, teaching helped him mold complex, technical arguments into laymen's terms.
With the concerns about the safety of vaccination resurfacing as a contemporary issue, however, Willrich has been invited to speak about the topic at a variety of institutions, including medical schools and societies.
"Some of these issues have returned with a vengeance today. There's a lot of fear and a lot of indifference. Because vaccines have been so successful, they've been a victim of their own success," Willrich says. "It's been a launching point for writing op-eds and doing radio interviews."
Willrich lives in Wellesley with his wife and two children. He's looking forward to sniffing out a topic for his next book this summer, and come fall, he will become the director of graduate studies in history, which he says has been an important part of his Brandeis experience, and the acting director of the Mandel Center for the Humanities.
Categories: Humanities and Social Sciences, Science and Technology