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Doctoral grads mark end of long journey
By Doug Boyd
ECU News Services
William Chappell, left, and Ossie Dyson completed their doctorates in microbiology and immunology this fall at the Brody School of Medicine at ECU. Photo by Cliff Hollis
GREENVILLE, N.C. (Dec. 15, 2011) — Now that he's finished his doctorate, Ossie Dyson might finally have time to take his wife on a honeymoon.
Classmate William Chappell will be glad to get some rest.
Dyson and Chappell are the two doctoral students who are completing their studies this semester at the Brody School of Medicine and are among the 1,100 graduate students who will receive master's or doctoral degrees at Friday's fall commencement exercises in Minges Coliseum. Both will receive doctorates in microbiology and immunology.
Doctoral students take courses for the first two years of their studies. After that, they concentrate on research. Altogether, Chappell has spent six years pursuing his doctorate; Dyson has spent five.
The Brody School of Medicine has doctoral programs in six scientific disciplines. Students pay tuition and fees and receive a research stipend for the work they do in the laboratory. Sixty-five students are working on their doctorates at the school.
The path to a Ph.D.
Chappell is from Sunbury, the one-stoplight town in the one-stoplight county of Gates in northeastern North Carolina. The rural setting had plenty of lessons for a young person interested in biology.
"I was always finding dead animals, bugs, stuff like that and picking them up and inspecting them," Chappell said. Family members warned him of the dangers, but he didn't stop. "They were like, 'Aw, you're gonna catch something.' It didn't matter."
In school, he wasn't much interested in most subjects. "I was a typical high school student who didn't want to do anything," he said. But science caught his attention.
After high school, Chappell attended Elizabeth City State University, graduating with a degree in biology. He chose ECU for his master's degree, where he got to do some research in labs at the Brody School of Medicine. "Once I got a taste of big-time science," he said, he knew he wanted to earn his doctorate.
Dyson, on the other hand, had his eyes on medical school. After growing up in Raleigh, he attended ECU, earning a bachelor's degree in biology and a master's in cell biology. He was working at the morgue at Pitt County Memorial Hospital, assisting on autopsies with ECU forensic pathologists. Pathology interested him as a medical specialty, and the research portion hooked him.
He decided that if research was what he wanted to do, a doctorate was the way to go rather than a medical degree.
Like Chappell, he explored other schools but stayed in Greenville. "When it came time for the Ph.D. program, I thought, 'What better place to go than ECU?'" he said.
Long hours in the lab
Dyson had gotten married, and his first child was born about the time he began his doctoral studies. His wife worked the second shift in the PCMH pathology department, so he would pick up their children in the late afternoon and care for them until his wife got home from work, around 11:30 p.m. On many nights, he would then head back to the Brody Building.
"The experiment would never end when I wanted it to," he said. "Every once in a while, you have moments where you have to spend the night in a lab, so I did that."
Chappell did, too. "I know we've passed each other at 12:30, 1 at night in the hall," he said. Like Dyson, he also got married while at ECU, to fellow student Vesna Chappell, who has since completed her doctorate in biochemistry and is working in a post-doctoral fellowship at ECU.
Encouraging young people to take an interest in science and pursue that interest is important, Dyson said. "My dad always encouraged me in science," he said, adding that he's worked with high school and college students who come to ECU to learn what laboratory research is like. He tells them to "take it in small pieces. You'll get it."
Chappell and Dyson represent what ECU is looking for in doctoral students, according to one faculty member: bright, ethical, hard-working and responsible students from a variety of backgrounds.
"Ossie and Will are a good example of this. In addition, they were very well-trained by their research mentors," said Dr. Rich Franklin, an associate professor of microbiology and immunology and graduate program committee chairman in the department. "I am certain that they will represent the department and university well as they enter the workforce."
Final steps
Both defended their dissertations in November. Chappell's is titled "p53 and NGAL: Dual Regulatory Roles in Advanced Prostate Cancer." At ECU, he has been mentored by Dr. James McCubrey, an internationally known cancer researcher. Chappell's step-father and two grandparents died of cancer, and he hopes to work in the pharmaceutical industry studying cancer, its causes and possible treatments and cures.
Dyson's dissertation is titled "Regulation of KSHV Replication by Glycoprotein B: Chronicles of a Virus and its Host." He has studied Kaposi's sarcoma-associated herpesvirus, which causes a form of cancer, in the lab of Dr. Shaw Akula at ECU. He wants to continue studying the virus and hopes to one day work for the Centers for Disease Control and Prevention. While at ECU, Dyson received the prestigious Ruth L. Kirschstein Predoctoral Fellowship from the National Institutes of Health.
Both have presented their research at major conferences; Dyson in Vancouver and Chappell as far away as Italy and Greece.
As they looked back on their studies, both said they if they could go back in time they would pursue doctorates all over again.
"My confidence level has increased dramatically," Dyson said. "I'm confident I can accomplish anything I want to now."
Doug Boyd
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PSE crews are hitting the streets every day of the year to provide you with safe and reliable electric service. More
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Learn how we maintain and inspect the PSE natural gas system — interconnected across some 2,900 square miles over six counties. More

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Edwards Center for Art and Dance
The Robert H. and Blythe Bickel Edwards Center for Art and Dance, named for Bowdoin's 13th president and his wife, opened in late August 2013 as the new home for visual art and dance at the College.
Located at the site of the former Longfellow Elementary School, the Edwards Center will provide space for modern art studios, classrooms, critique space, and student exhibitions in the visual arts and dance, including a state-of-the art digital media lab. The single location will, for the first time, enable faculty and students engaged in dance, painting, drawing, photography, sculpture, architecture, printmaking, woodworking, and digital media and design to work together under a single roof, creating a cohesive arts community and numerous new opportunities for artistic synergy.
Until now, the visual arts and dance have been scattered across campus and throughout the town of Brunswick. A $6.5 million renovation and an interior expansion of the 38,129 square foot school building (by creating a two-story space in the former gymnasium) will result in a facility of nearly 45,000 square feet that will consolidate in one location visual arts and dance programs now housed in six different locations.


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People > Faculty
Brian Otis
Dr. Brian Otis
Phone: 206.616.5998
Office: M430, Paul Allen Center
E-mail: email@example.com
University of California Berkeley, 2005 Ph.D.
University of California, Berkeley, 2002 M.S.
University of Washington, Seattle, 1999 B.S.
Brian Otis joined the University of Washington Department of Electrical Engineering in 2005. His M.S. and Ph.D. were completed at U.C. Berkeley with Prof. Jan Rabaey. He has worked previously at the University of Washington Kelly Tremblay Brain and Behavior Laboratory, the U.C. Berkeley Ralph Freeman Neuroscience Lab, Intel Corporation, Agilent Laboratories, and Google Inc. He is a member of the Technical Program Committee of the International Solid-State Circuits Conference (ISSCC) and is an Associate Editor of the Journal of Solid State Circuits (JSSC).
Research Interests
One of my passions is exploring the fundamental limitations of power and size of integrated circuits and systems. I run a chip design research lab that designs tiny, low power chips for a variety of applications (neural recording, implants, active contact lenses, wearable on-body wireless sensors, environmental monitoring, etc). To realize these systems, we work on low power radios, systems running off wireless power transfer, systems integrated onto non-traditional substrates, and many types of biosignal interfaces.
Click here for a video on our Encounternet project.
In general, the interface between electronics the outside world is of interest to me: we have published on RF transceivers, biosignal interfaces, MEMS sensor interfaces, intertial sensors, etc. Finally, I have a strong interest in time/frequency references. Through a longstanding collaboration with Avago Technologies, we are working on extremely small, low power, and pure frequency references and clocks.
Please visit the Wireless Sensing Group website to learn more and download papers.
Fall 2011: Undergraduate Radio Lab (ee400)
Spring 2011: Devices and Circuits II (ee332)
Winter 2011: Analog IC Design (ee473)
Fall 2010: Undergraduate Radio Lab. An Introduction to Wireless Circuits and Systems (ee400e)
Winter 2010: Devices and Circuits II (ee332)
Fall 2009: Linear Analog Integrated Circuit Design (ee473)
Spring 2009: Undergraduate Radio Lab. An Introduction to Wireless Circuits and Systems (ee400e)
Winter 2009: Devices and Circuits II (ee332)
Fall 2008: Linear Analog Integrated Circuit Design (ee473)
Spring 2008: Devices and Circuits II (ee332)
Fall 2007: Linear Analog Integrated Circuit Design (ee473)Spring 2007: Radio Frequency Integrated Circuit Design & Analysis (ee538)
Winter 2007: Topics in Low Power Microsystems (ee500)
Fall 2006: Linear Analog Integrated Circuit Design (ee473)
Spring 2006: Radio Frequency Integrated Circuit Design & Analysis (ee538)
Fall 2005: Linear Analog Integrated Circuit Design (ee473)
Interested in undergraduate independent study?
2011: U.W. College of Engineering Junior Faculty Innovator Award
2009: National Science Foundation CAREER Award
2008: University of Washington Electrical Engineering Outstanding Teaching Award
2007: University of Washington Electrical Engineering Outstanding Research Advisor Award
2004: Berkeley Sensor and Actuator Center Industrial Advisory Board Best Paper Award
2004: Analog Devices Outstanding Designer Fellowship
2003: U.C. Berkeley EECS Dept. Seven Rosen Funds Departmental Award for Innovation
2003: ISLPED Student Design Contest Competition Award
2002: ISSCC Jack Raper Outstanding Paper Award


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Sox ponder three criteria before promoting BradleyBy SCOTT LAUBER
Boston Herald
March 22. 2013 10:55PM
FORT MYERS, Fla. - The daily dispatches are beamed back to New England, each more breathtaking than the last.
A double? Two more hits? Another strong throw?
By now, Jackie Bradley Jr. must seem to anyone who hasn't seen him play like a cross between the second coming of Willie Mays and a superhero.
Bradley isn't quite so impressive. But the Red Sox' touted center field prospect has gotten positive reviews from several of the scouts who sit behind home plate and jot notes to take back to their teams.
"In my opinion, he truly does have a chance to be an above-average major league center fielder," a scout from one National League club said Thursday. "He's fun to watch. I think he's good enough that he could make (center fielder Jacoby) Ellsbury a nice trade chip for them later in the season."
Lately, though, any discussion of Bradley has been focused on the short term, specifically whether the 22-year-old is ready to merit a spot on the Opening Day roster despite having never played above Double A, a decision that goes beyond his .429 average this spring. (Friday, he played center field and left field, and doubled for one of Boston's two hits in a 1-0 loss to Toronto.
The Red Sox probably won't render their verdict until at least the middle of next week. General manager Ben Cherington, of Meriden, N.H., outlined three criteria that will be taken into account with regard to Bradley.
Will he play every day? Is he really ready for the majors? Does he make the Red Sox better?
"If we use that to guide us, we'll more often than not make the right decision," Cherington said. "We have to see how it plays out. There are other factors, but those are the most important."
One of those other factors: major league service time. If Bradley spends more than 172 days in the majors, the Red Sox would risk allowing him to reach free agency after the 2018 season rather than 2019. Bradley's prime competition, outfielder Ryan Sweeney, would require only a spot on the 40-man roster but offers less upside.
But the Sox also play their first 13 games against AL East rivals. Given the fact that David Ortiz is bound for the disabled list, Bradley would have an opportunity to play every day, likely in left field. And one team official admitted this week that Bradley could potentially bring youthful energy to the lineup early in the season.
"We have to consider all of the data points and remember that every year in Boston is important," Cherington said. "With a young player like this, is he really ready for it?"
Indeed, that may be the most pressing question. Another NL scout worried that sending any young player back to the minors after his initial call-up could lead to a "letdown" and stunt development. But he also said that a conversation before a game last season in the minors convinced him that Bradley can handle anything.
"I met him last year, and he made a comment that stuck with me," the scout said. "He said, 'Guys who know who they are are guys who are successful. I know who I am.' That puts him over that hump. He might be mature enough to make that (Double A to the majors) jump. He has all the intangibles that make a good player a really good player."
So, how good is Bradley?
The aforementioned scout compared Bradley to Red Sox outfielder Shane Victorino during his prime years with the Phillies. From 2006-11, between ages 26-30, Victorino batted .281 with a .795 on-base plus slugging percentage, averaged 14 homers, 30 stolen bases and 59 RBI, won three Gold Gloves, twice finished in the top 20 in the NL MVP balloting and twice was selected to the All-Star Game.
According to the scout, Bradley lacks Victorino's track star speed but possesses more discipline at the plate and better instincts in the outfield.
"I say that to myself, too," Victorino said. "I see a lot of the same attributes. He can run, he's a solid contact hitter, can hit with a little bit of power. I will definitely say he's better than me at 22 years old. I didn't become the player I am until 25, 26. It's exciting to have people comparing him to me."
Eventually, Victorino and Bradley will share the same outfield. Could it happen in the season opener at Yankee Stadium?
"It's hard to ignore what he has done this spring," Cherington said. "It's been fun to watch. One way or another, we know he's going to be a good player. We'll see when that starts for him. We're happy he's on our side."
Said the first NL scout: "I'm sure their expectations are to win this year because every team has a chance in (the AL East). It'll be interesting to see what they do. But he's the kind of kid, I don't think it'll hurt him either way."


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Featured News - Current News - Archived News - News Categories
The week will feature 2 nights of performances by Pearl Jam and special performances by Soundgarden frontman Chris Cornell, the Avett Brothers, Fleet Foxes frontman Robin Pecknold, Dierks Bentley
Continuing in its tradition of paying tribute to the best in music, NBC's "Late Night with Jimmy Fallon" (Monday-Friday, 12:35 a.m.) will highlight Pearl Jam's catalogue for the entire week of Oct. 21-25. The weeklong celebration is timed to the Oct. 15 release of the band's new album, "Lightning Bolt." Each night, the show's musical guest will perform a specially selected song from the band's expansive discography.
On Monday, Oct. 21, Fallon welcomes Soundgarden frontman Chris Cornell to perform the song "Footsteps" with the Avett Brothers. The instrumental of this song previously appeared in a different form as the track "Times of Trouble" in the 1991 self-titled album by Temple Of The Dog, which featured Cornell collaborating with the members of Pearl Jam.
Fleet Foxes frontman Robin Pecknold will give his first television performance in nearly two years when he covers "Corduroy" backed by special guests on Tuesday, Oct. 22.
Wednesday night, country music superstar Dierks Bentley will be joined by Pearl Jam lead guitarist Mike McCready and The Roots for a one-of-a-kind performance. Bentley previously covered "Wish You Were Here" as part of "Late Night's" Pink Floyd tribute week in 2011. His 2009 album "Feel That Fire" features a guest appearance by McCready on the song "Life on the Run."
Pearl Jam closes out the week with performances on Thursday, Oct. 24, and Friday, Oct. 25. These will be Pearl Jam's only television appearances in conjunction with the new album. The band has not appeared on network television since a two-night stand on "Late Night" in September 2011 in support of the retrospective film and book "Pearl Jam 20."
Separately, other guests scheduled to appear on "Late Night" during this themed week include Alec Baldwin and Kevin Connolly (Monday), Johnny Knoxville and Hailee Steinfeld (Tuesday), Julie Bowen (Wednesday), Javier Bardem (Thursday) and Penelope Cruz and Judd Apatow (Friday).
For more on "Late Night," visit NBC.com's official show site: http://www.latenightwithjimmyfallon.com/.


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Systems Biology of PNEUMOVAX®23 and PREVNAR 13®
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01307449
Recruitment Status : Completed
First Posted : March 3, 2011
Last Update Posted : December 13, 2017
- Study Details
- Tabular View
- Results Submitted
- Disclaimer
- How to Read a Study Record
Vaccination is the most effective way of preventing infectious diseases. Despite the success of vaccines in general, vaccines induce diminished antibody responses and lower protection in the elderly in particular. This could be explained by a defect in the early responses of an ageing immune system. A better understanding of the basic immunological mechanisms that mediate vaccine efficacy is incomplete. Such information is critical and could greatly decrease both the cost and the time to new vaccine development particularly for the geriatric population.
In this trial, the investigators will study the immunologic differences of two FDA approved licensed pneumococcal vaccines between a younger and an older group. Twenty two healthy volunteers between the age of 25-40 and sixty six healthy volunteers between the ages of 60-89 will be enrolled in the study. Each participant in the study will be given one pneumococcal shot. Blood work will be obtained prior to vaccination, one day, three days, seven days, fourteen days, as well as one month and six months after vaccination. Throughout the duration of the study, the participants will be monitored for safety.
|Condition or disease
|Pneumococcal Infection
|Biological: PNEUMOVAX and PREVNAR Biological: Pneumovax or Prevnar
|Not Applicable
RATIONALE: PCV13 [13-valent pneumococcal conjugate vaccine (Prevnar®13)] induces better functional immune responses when compared to PPV23 [23-valent pneumococcal polysaccharide vaccine (Pneumovax®23)] in older naïve adults. We hypothesize that this is due to intrinsic defects in innate responses that could explain the poor immunogenicity of PPV23 when compared to PCV13. Therefore, we propose to extensively study innate and adaptive immune responses generated after administration of either pneumococcal polysaccharide or conjugate vaccines in older adults.
STUDY DESIGN: Single center, open label study in which adult healthy volunteers will be vaccinated with either PPV23 or PCV13. Blood samples will be collected on Days D0 (at enrollment) and D1, D3, D7, D14, D30 and D180 post vaccination to study innate and adaptive immune responses.
Even though PPV23 and PCV13 are considered safe, volunteers will be asked to report any local or systemic AEs from Day 0 (vaccination) to Day 7 . Reactogenicity events will also be evaluated by injection site examination on visits at D0, D1, D3 and D7. Also volunteers are asked to report any local or systemic AEs for 30 days post vaccination and any SAEs for 180 days post vaccination. Volunteers are also asked to report local and systemic AEs developing the day of a blood draw.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|88 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Basic Science
|Official Title:
|Systems Biology of 23 Valent Pneumococcal Polysaccharide Vaccine (PNEUMOVAX®23) and 13-valent Pneumococcal Conjugate Vaccine (PREVNAR 13®)
|Actual Study Start Date :
|April 2014
|Actual Primary Completion Date :
|July 2017
|Actual Study Completion Date :
|July 2017
Experimental: Older Group
Participants between the ages of 60-89
Biological: PNEUMOVAX and PREVNAR
Give either 1 dose of PNEUMOVAX or PREVNAR to all participants
Other Names:
Biological: Pneumovax or Prevnar
Receipt of one vaccination at D0
Experimental: Younger Group
Participants between the ages of 25-40 years
Biological: PNEUMOVAX and PREVNAR
Give either 1 dose of PNEUMOVAX or PREVNAR to all participants
Other Names:
Biological: Pneumovax or Prevnar
Receipt of one vaccination at D0
- Number of participants with innate immunity signatures that correlate with the quality of antibodies after PNEUMOVAX and PREVNAR [ Time Frame: 2 years ]The primary outcomes will identify the number of participants with innate immunity signatures in the young and older groups that correlate with the quality of antibodies produced after PNEUMOVAX and PREVNAR
- Number of participants with specific B cell responses that correlate with the innate immune signatures after PNEUMOVAX and PREVNAR [ Time Frame: 2 years ]The secondary outcomes will identify the number of participants with a positive B cell response to PNEUMOVAX and PREVNAR particularly looking at the antibody repertoire, quantity of antibodies and plasmablasts
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|25 Years to 89 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Able to understand and give informed consent.
- Immunocompetent community dwelling subjects between the ages of ages of 25-40 and 60-89 years.
Exclusion Criteria:
- Prior vaccination with pneumococcal vaccine.
Receipt of any of the following products:
- Blood products within 3 months prior to study entry or expected receipt at any time after study entry*.
- Any live virus vaccines within 4 weeks prior to study entry or expected receipt within 4 weeks after study entry*.
- Any inactivated vaccine within 2 weeks or expected receipt within 2 weeks after study entry*.
Presence of co-morbidities or immunosuppressive states such as:
- Chronic medical problems including (but not limited to) insulin dependent diabetes, severe heart disease, severe lung disease, severe liver disease, cerebrospinal fluid leaks, severe kidney disease, autoimmune diseases, severe gastrointestinal diseases and grade 4 hypertension per CTCAE criteria** .
- Alcohol, drug abuse or psychiatric conditions that in the opinion of the investigator would preclude compliance with the trial or interpretation of safety or endpoint data.
- Impaired immune function or known chronic infections including, but not limited, to known HIV, hepatitis B or C; organ transplant; immunosuppression due to cancer; current and/or expected receipt of chemotherapy, radiation therapy, steroids*** (i.e., more than 20 mg of prednisone given daily or on alternative days for 2 weeks or more in the past 90 days , or high dose inhaled corticosteroids**** or any other immunosuppressive therapies (including anti-TNF therapy), functional or anatomic asplenia and congenital immunodeficiency.
Conditions that could affect the safety of the volunteers such as:
o Severe reactions to prior vaccinations.
o An allergy to any component of the study vaccines (phenol, aluminum, CRM197 protein, succinic acid, Polysorbate 80).
- History of Guillain-Barré syndrome.
- History of bleeding disorders.
- Volunteers with any acute illness* including, but not limited to, - fever (> 100.4 F [> 38 C], regardless of the route) within 3 days prior to study entry.
- Volunteers with social conditions or occupational conditions or any condition that in the opinion of the investigator might interfere with compliance with the study and vaccine evaluation.
Pregnant or breast feeding or women expected to conceive within 30 days after vaccination *****
An individual who initially is excluded from study participation based on one or more of the time-limited exclusion criteria (e.g., acute illness, receipt or expected receipt of live or inactivated vaccines ) may be reconsidered for enrollment once the condition has resolved as long as the subject continues to meet all other entry criteria.
Grade 4 hypertension per CTCAE criteria is defined as Life threatening consequences(e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis) urgent intervention indicated. ***Subjects receiving > 20 mg/day of prednisone or its equivalent daily or on alternate days for more than 2 weeks may enter the study after therapy has been discontinued for more than 3 months.
- High dose ICS is defined as: > 960 mcg/day of beclomethasone dipropionate or equivalent ***** Women of child-bearing potential (not surgically sterile via tubal ligation, bilateral oophorectomy or hysterectomy or who are not postmenopausal for ≥1 year) must agree to practice adequate contraception that may include, but is not limited to, abstinence, monogamous relationship with vasectomized partner, barrier methods such as condoms, diaphragms, spermicides, intrauterine devices, and licensed hormonal methods for 30 days before and 30 days after receiving PPV23 or PCV13.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01307449
|United States, Georgia
|Hope Clinic of the Emory Vaccine Center
|Decatur, Georgia, United States, 30030
|Atlanta VA Medical Center
|Decatur, Georgia, United States, 30033
|Principal Investigator:
|Nadine Rouphael, MD
|Emory University
|Responsible Party:
|Nadine Rouphael, MD, Emory University
|ClinicalTrials.gov Identifier:
|NCT01307449 History of Changes
|Other Study ID Numbers:
U19AI090023 ( U.S. NIH Grant/Contract )
IRB00078300 ( Other Identifier: Emory University IRB )
|First Posted:
|March 3, 2011 Key Record Dates
|Last Update Posted:
|December 13, 2017
|Last Verified:
|December 2017
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
Keywords provided by Nadine Rouphael, Emory University:
pneumococcal vaccine
immune responses
Additional relevant MeSH terms:
Pneumococcal Infections
Streptococcal Infections
Gram-Positive Bacterial Infections
Bacterial Infections
Heptavalent Pneumococcal Conjugate Vaccine
Immunologic Factors
Physiological Effects of Drugs


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EC of PL writes "Here is Play Legit's Top 5 Betrayals in Gaming."
The Biggest Betrayal in Gaming was on May 1991 CES when Nintendo betrayed another Japanese company Sony in favor of a foreign company Philips. It was considered a serious violation of the Japanese code of honor in Japan. Nothing can top that.
Leaving your husband for the Mailman and taking the kids with you.
"Sorry Flashbacks"
No Braid? In the end [SPOILERS] the princess we want to save spends a whole level trying to kill us. Of course, the game has all those meanings, nuclear bomb and whatnot, but looking for the princess for the whole game and end it with her running away and trying to kill me felt like a huge betrayal. [/SPOILERS]
I'd put Master Miller from MGS, to this day I still vote that as my #1 all time plot twist in any video game
Master Miller in MGS wasn't really a betrayal, it was just a plot twist since He was never really Miller to begin with, Miller was dead prior to the event of the Game and it was only until Liquid ripped off the shades and let his hair down that anyone realizes what had happened.


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text:
Laconia shop's ribbon candy a sweet holiday tradition for more than a centuryBy PAULA TRACY
New Hampshire Union Leader
December 09. 2012 10:38PM
LACONIA - The smell of peppermint was enough to sting your eyes in the basement of the Kellerhaus in Weirs Beach as a crew of three worked to preserve a Christmas tradition - making ribbon candy.
Kellerhaus, a small chocolate and ice cream shop, has been making this holiday treat for more than 100 years and attracts customers from as far away as Europe.
The temperature in the copper kettle of sugar and water reaches 300 degrees before Dave Dutton pours the 30 pounds of the confection onto a heated table. Dutton left the corporate life as a chief financial officer and, with his wife, Mary Ellen, a nurse, switched careers to buy the candy and ice cream shop he recalled visiting at Lake Winnipesaukee as a child.
The Duttons make more than 100 types of candy, but said many New Englanders wouldn't consider it Christmas without ribbon candy.
"It's not like it's the most delectable thing on earth," Dave Dutton said of the candy, which can have flavors of vanilla, spearmint, clove, licorice, wintergreen, cinnamon, peppermint, molasses or peanut butter.
Production is dictated by the weather. When temperatures and humidity drop, the Duttons call on Kim Olszak. She began working the circa-1886 crimper at age 14; this is her 23rd year making the candy.
On Thursday, Olszak used gloves to protect her from the hot candy as she kneaded it, while Mary Ellen Dutton took a large ball of it and added food coloring.
Dave Dutton lifted the 30 pounds of clear peppermint onto a hook. As he kneaded, it became opaque. He then laid the hot mass out on another hot table and added three long strips of the red-colored candy evenly onto the slab.
The antique crimping machine was turned on and began to whir as Dutton pulled and teased the candy so it could go through the machine. His wife kept the loops forming at the other end as it went down the production line to Olszak.
Four generations of Kellers, beginning with Otto Keller, have used the machines, which were originally hand-operated. Dutton noted that every time a candy operation went out of business, the Kellers would buy the machines, so there are several on the premises if parts are needed.
Dutton said he has been crafting the candy for seven years now. When done well, the candy is the consistency of a potato chip. Too thin and it can cut your tongue. Too thick and it is like a candy cane.
Kellerhaus makes about 1,000 boxes a year and sells it in four-flavor and eight-flavor packages.
Customers are loyal. One 94-year-old Newmarket woman sends a check each year for $60 to get her six boxes in the mail. The boxes have traveled to Europe and, in recent years, to troops serving in Iraq.
The Duttons said they have about eight runs a year of ribbon candy. When the sign goes up on Route 3 outside the store, the run on ribbon candy begins. It will take only a day or two to run out, the Duttons said.
The Duttons are thinking about making the ribbon room climate-controlled so that even on warmer days, they can keep the Christmas tradition alive.
Business Human Interest Food Holiday or vacation Photo Feature


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chuckeles wrote:How did you begin to lucid dream? What techniques did you use back then and what do you use now?
When I was a young girl, about five, I had some lucid dreams. But when I was a teenager, that is when I started having tons of lucid dreams. Of course, I didn't know what a luci dream was at the time. But the reason I was having them was because of meditation. It made me very self aware.
When I was finally able to research all of this I tried about every technique I could find. I was so interested, it was constantly on my mind.
My favorite techniques now are WILD, DEILD, and MILD. But I still enjoy trying other ones.
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Simulation of Thermal Sensor for Thermal Control of Satellite Using COMSOL MultiphysicsG. Mangalgiri
BITS Pilani K K BIRLA GOA CAMPUS
Goa, India
The actuator comprises of a temperature sensitive composite deflecting beam, a piezoelectric substrate and a field effect transistor. The temperature rise causes an expansion in the composite beam thereby causing it to deflect. The deflecting beam impinges on the piezoelectric crystal and generating voltage.
Response curves for the deflection versus temperature for temperature ranges considered in the safety limit of the spacecraft will be obtained by modelling the equations relating temperature rise and deflection considering laws of physics. The response for deflection versus voltage and deflection versus the final current output of the FET will be obtained.
- mangalgiri_presentation.pdf - 0.78MB
- mangalgiri_paper.pdf - 0.66MB


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Possible fake KH2 White Ouija
That guitar has a case originally, because it was sold here with one
However, I suspect you have purchased this
One was $9K, the other $300
And they have even used that same serial number on black ones
Dude if you buying something rare as that, you must know it coming with OEM case, COA, metal battery case, the whole shebang . And if new was around 9-10k , if you find it used for 5k it's steal, but if it's like 2k than it's 99% fake :)
Thanks for all of your input...I didnt pay that much for it so I knew it was most likely a copy...still enjoy the guitar so it is not going to kill me that much...just means it has no resell value...but I wouldn't have sold it if it was legit anyway.
I would dare contend that you would(should) have known the minute you picked it up that it wasn't the real deal?? I guess if you haven't seen a real one up close and have no point of reference then maybe....
Ok, wanna share what was asked/payed price :D ????
And it's not the point you will not sell it , the point is it does not sound even like entry 400$ KH202, let alone real custom shop KH2 , you you are missing 3/4 chunk of sound :/
I paid $800...I'm not a good enough player for me to really tell tonal differences....more of a Hammett and guitar fan...I have a LTD KH-602 which is about a lb heavier than the one I bought....should have ponied up another $200 for the LTD Ouija...but still enjoy the one I bought...plays nice enough for me.
eh, ok, 500$ is not (too) bad lesson ... be careful next time, fakes are all around ... post pictures of yours here ... usually there is narrow stickers A-Z . if i would be you, i would take back guitar where i bought it and offer payback or police ...
HAHAHAHA!!! You paid $800 for a $300 guitar, and now you're stuck with it!!!
Dumbass. Probably should have asked about it BEFORE you bought it.
I too have purchased a ouija white and would like it authenticated. It has coa and original case. Is there other ways I can tell?
Yep, all we need to know is the price to be able to tell if it's the real deal or not lol.


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26 U.S. Code § 2664 - Repealed. Pub. L. 111–312, title III, § 301(a), Dec. 17, 2010, 124 Stat. 3300]
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Section, added Pub. L. 107–16, title V, § 501(b), June 7, 2001, 115 Stat. 69, related to termination of applicability of chapter to generation-skipping transfers after Dec. 31, 2009.
Effective Date of Repeal
Repeal of section applicable to estates of decedents dying, and transfers made after Dec. 31, 2009, except as otherwise provided, see section 301(e) of Pub. L. 111–312, set out as an Effective and Termination Dates of 2010 Amendment note under section 121 of this title.
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


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I was going to post this in Druskin's thread below but I think it deserves a separate thread because it is frustrating to read replies that label the act of suicide as 'selfish' or immoral in the year 2011.
First, while some might argue it is selfish of the person committing suicide to do so, can't one likewise say that it is 'selfish' of the others who insist that a person must continue living when he is suffering beyond what he is willing to bear ? That person is just trying to shame the other into staying alive until it's more convenient to them for you to die. And aren't we all born without prior consultation anyway ? Additionally, I've always wondered why most people believe that suicide is acceptable if it is self-enacted euthanasia, a response to physical pain, but not as a response to emotional pain. Why do many assume psychological pain to have little importance? This attitude/ideal leads logically to the conclusion that rape should be punished according only to the physical injuries sustained.
There are a number of reasons why someone might commit suicide:
1) Social standing (shame or dishonor).
2) Physical pain or terminal illness.
3) Some instrumental reason -- to draw attention to a cause, or to free another person from their obligations.
4) Emotional pain or loneliness.
5) Mental illness (i.e. severe depression or body dysmorphic disorder).
Concerning emotional pain: to dismiss it as trivial or transient is a mistake; the person in best place to judge considers it overwhelming, and who ever chooses such a final solution to a temporary problem ? Those who commit suicide do not consider their problems transitory. If it can be the right decision for one in physical pain, maybe it is sometimes (often) the right decision for those in psychological pain. The determination of whether it is best to suffer through a miserable present in the hope of getting to a possibly better future is a value judgment. A person could legitimately decide a hopefully better future does not justify choosing to experience an unbearable present. No one should claim the right override, by force, a person's value judgments and decisions about something as personal as this.
Could it be that suicide reminds society that life is ephemeral and that there are some people who regard it as a crock of sh*t ?... THIS is taboo. We are supposed to think that life is great & we should cherish every minute of it, & when we die, we don't really die, we live on, etc, etc. So suicide is considered an act of betrayal of social conventions. People who are suicidal aren't killing themselves out of a desire to hurt those around them -- it's unreasonable to expect them to continue suffering because of that consequence, I think.
We don't know that life is a great gift. More likely it is an insubstantial little thing in the greater scheme of things; but as far as we know, it is all we have. Essentially life constricts us; gives us boundaries. If a person's life is going very badly and they can't deal with it, they should be able to liberate themselves from it. The reason we should in general let people take their own lives if they want to is simply that most people are experts in their own happiness and know better than anyone else what will, or will not, make them happy. So it isn't that we've got a basic right to destroy ourselves.... Rather, we have a unique perspective on our own lives and thus we are (normally) better-placed than others to make judgments about whether our lives are worth continuing. As for those who don't consider a person's life their own property, to do with as they wish, I challenge them to justify this perspective without falling back on religious dogma or a functionalist societal view that disregards the well-being of human beings.


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The bravery of his handlers may be all that saved Harness Jewels winner Franco Emirate from perishing in Thursday's fires in Canterbury.
The outstanding pacer was one of four horses that had to seek shelter in an aqua walking machine at the property of Brian Court as the fire bore down.
The quartet of horses couldn't be moved in time as the flames encircled Court's property near Prebbleton.
"If it wasn't for my staff, led by Annabel Tilson, this could have been horrific," Court told the Herald.
"They were very brave and put their lives at risk for the sake of the horses."
Court trains thoroughbreds but also uses his property to help standardbreds rehabilitate with an aqua walker, a machine which enables the horses to work in circles up to their waist in water.
"It is like a normal walking machine for horses but dug into the ground so they can walk around in about a metre of water to increase the resistance on their legs.
"But on Thursday the horses had to shelter there as the fire passed by."
Court was at the Magic Millions sales in Australia when the fires struck and he says his staff and neighbouring horsepeople helped to avert massive loss of equine life.
"We had people in paddocks rescuing horses that were only three or four metres from the treeline fences, which were on fire."
Court says 20 of the 24 horses were evacuated with great difficulty as police restricted the handlers' movements.
"Every time somebody left with a few horses the police were reluctant to let them back in because of the risk.
"But these are horsepeople and they were never going to leave the horses behind so they eventually wore the police down."
The fire raged on both sides of Court's property, destroying paddocks, fences and trees which shelter the property.
But the already dangerous situation became more precarious when Franco Emirate took fright and refused to be loaded onto a rescue transporter.
"We couldn't leave him behind so the staff took him and three other horses and walked them around in the water to keep them cool and safe."
Eventually the fire passed without getting to the main stabling area but any horses in the outlying paddocks could easily have been lost.
"We were fortunate but a lot of that comes down to the way Annabel handled the situation and the help of so many people.
"They had a real battle but they were willing to risk their lives for the horses."
Among the other well-known pacers on the property was last season's Miracle Mile contender Raglan, the winner of over $500,000.
Court says he has plenty of neighbours whose horses have had similar scares but heard no reports of horses dying.
"A lot of people worked hard and under amazing circumstances to save horses. We had three weanlings in a neighbouring paddock and I was sure they would be dead because our people couldn't get to them.
"But somebody got to their gate and opened it so they could run free and we have got them back safe and sound now."


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Selena Gomez Gets Her First Tattoo
Selena Gomez got inked! The singer recently went under the needle and got her first-ever tattoo!
Just like her boyfriend Justin Bieber, Selena Gomez is now a member of the tatted pop star club. The 19-year-old singer got a small heart inked on her wrist at a tattoo shop in Hollywood.
"She got a little heart tattoo at Under the Gun, in Hollywood by Louie Gomez," shop employee Jordan Sandoval tweeted about Sel stopping in for her first tat. He then wrote, "Phone blew up because I tweeted that @selenagomez got a #tattoo. Her fans get down! Gained some new followers too. Tiny Heart tat. Lol."
Selena's tattoo is subtle and cute, much like herself! While Selena didn't go crazy in the tattoo studio, her boyfriend Bieber is more daring when it comes to permanent body ink. The 'Never Say Never' singer has numerous tattoos, one of which is a large portrait of Jesus on his calf, in honor of Bieber's devout Christian faith.
What do you think of Selena Gomez's teeny tiny tat? Let us know in the comment section!