text:
A/N: Hey this story is a work in progress about what happens after the movie. If you've read the book you'll recognize one of the scenes. It was too perfect not to include. I don't own anything.
As we drove through the deserted streets of the city I couldn't help but turn to stare at R and the vivid red blood flowing from various wounds on his body. Although I should've been horrified, I couldn't help the elation I felt at seeing the physical evidence of R's newfound humanity. The uneasiness began as we got closer to the stadiums' medical center and I realized this evidence of humanity was also a threat to R's new life. I wanted to protect him just as he protected me during that failed scavenge trip and the subsequent stay at the airport hive. I'm still not sure what made him want to keep me safe but it was my turn to keep him safe now.
"How are you feeling R?" I asked him.
"Dizzy. Cold" he replied still having trouble with his speech.
"Just keep your eyes open, stay with me! We're coming up on the med-center now and we'll get you patched up" I say as my heart starts to seize up. It's only been just over a week since I met R but I've come to rely on him so much I can't begin to imagine watching him die just as we found the cure. Not that we really know what the cure is yet. All I know is that after our kiss in the fountain his eyes dilated and turned a startling shade of blue. The next thing I knew my dad shot him and he started bleeding real blood.
"We're here son, let's go" my dad said as he got out of the SUV and started barking orders at soldiers and medics.
"Julie…" R rasped looking at me in panic as the soldiers started opening the car door.
"It's ok R. They're here to help you inside. The doctors are going to stop your bleeding and we'll get you a transfusion or something. I promise I'll stay with you. Don't worry." At my last words I could see R relax slightly. I don't know where his trust in me came from but as I followed the stretcher R was laid upon into the hospital, I could tell that he was still nervous about all the living soldiers surrounding him. I knew that my dad believed me about R's change but not everyone got to see the transformation first hand. It would take some time to convince the rest of the refugees but I knew the soldiers wouldn't disobey orders from my dad. And the blood still pumping from his recent bullet wound gave them pause enough to realize he was no longer part of the undead army we were trained to battle.
The next few hours went by in a blur as soldiers and medics worked over R's body. My dad made sure I was able to stay in the room but I had to stay out of the way. One of the doctors placed a mask over his face and started the anesthetic. Our eyes met as his began to droop and the fear I saw was heart-wrenching.
My limbs felt heavy when I opened my eyes a few hours later. It reminded me so much of waking for the first time as one of the undead that I nearly panicked until I realized I still had all my memories of the past week and a half. I wanted to sigh in relief until I realized that one of the side-effects of my recent change of lifestyle was the ability to feel pain. My shoulder was unbearable. I could feel various scrapes and bruises all over my body. Even my head felt like it was splitting open. I realized that falling into the fountain and protecting Julie most likely did cause my skull to literally split open. I'm not sure what happened but as we fell all I could think about was making sure Julie got away from those Boneys. In those few seconds I wondered if my body would break and I would finally get the permanent death I had wished for just as I found a reason to live. I wondered if I would just keep moving as I had all the other times I had been hurt while infected. I wondered if the changes I had started feeling ever since meeting Julie would continue if I died. I worried that I wouldn't be able to keep Julie safe from the effects of such a fall. I tried to wrap my body around her to create a cage of protection for her fragile body, but what if we landed the wrong way and she broke her leg. The boneys would surely get her then. I wanted Julie to live a long life. I wanted her to be happy.
As I slowly blinked the grogginess from my eyes, my fingers twitched and I felt a small, cool hand tighten around them. I looked to my right and there she was. Julies red rimmed eyes and tear-stained cheeks came into view and the watery smile she graced me with was enough to make all this pain worth it. While I knew the pain meant I was alive again, I realized I could still only manage the feeblest of smiles to return. It wasn't that my chest didn't tighten in response to her gaze, my muscles just couldn't function in the way required to show my emotions. I would have to re-learn these muscle-memory responses and work the stiffness out of my limbs.
"Hey there you" Julie said as her shoulders visibly relaxed. "I was getting worried."
"What… happ-end?" I asked.
"The medics removed the bullet and stitched you back up. You had quite a few fractured bones from the fall too. They stopped the bleeding and wrapped up the fractures then gave you some pain-killers, but they said you'll feel pretty groggy for a while after first waking."
"Still in… pain" I choked out my scratchy throat.
"Here," Julie offered me a glass of water and a pill. "It's one of the super drugs they came up with when this whole epidemic started. It should relieve the pain but you just have to be careful not to pull out the stitches. They said your bones were fusing back together surprisingly we'll have to be careful not to make them worse."
"Thank you" I said as she helps me sit up and take the pill. I realize how parched I was when the water relieves a fraction of the pain immediately.
"R," Julie sobbed as she cupped his face in her free hand. Her right hand still clenched tightly around his. "I was so worried."
I looked into her shining eyes and with the help of the super drug moving through my system, removed my hand from hers to slowly wrap around her shoulders. I pulled her into my embrace as she carefully laid her head on my uninjured shoulder. "It's ok. I'm going to be ok" I whisper into her ear as I kiss her hair.
"We both will" she says, pulling back to look at my face.
The next day I am ready to leave the medical center. The building has begun filling up with the newly exhumed coming in for medical attention. Julie tells me that the front gate has been opened up and search parties sent out to find those who were cured and needed help with wounds sustained during the battle with the boneys. I try looking for M and fear the worst when I don't see him. I begin to ask Julie in my dis-jointed speech but she answers before I finish.
"He came in earlier when you were still in surgery. Nora found him trying to ask one of the guards about you. She brought him in but he was pretty banged up and I think he's recovering now. We can find him later but right now they need us to clear room for new patients."
So we leave the medical center and as I squint into the harsh sunlight outside, Julie grabs my hand to stop me.
"Look at what you did R!" she exclaims gesturing to the exhumed populace that filled the area outside the med-center. They stared at us in the same way they did at the hospital and deep inside the stadium but with more light in their eyes than ever. "You're curing them somehow."
"We" I insist. "We're… curing them."
She pounces on me, wrapping herself around me and squeezing so hard I feel my semi-healed bones creaking. She kisses me and her warmth radiates into my body. I feel a rush of sensations as my own warmth pushes back.
Julie goes still. She releases me and pulls back a little, glancing downward. A wondering smile creeps across her face.
I look down at myself, but I don't need to. I can feel it. My hot blood is pounding through my body, flooding capillaries and lighting up cells like Fourth of July fireworks. I can feel the elation of every atom in my flesh, brimming with gratitude for the second chance they never expected to get. The chance to start over, to live right, to love right, to burn up in a fiery cloud and never again be buried in the mud. I kiss Julie to hide the fact that I'm blushing. My face is bright red and hot enough to melt steel.
As R and I walk through the streets inside the walled off refugee camp, I realize that he is now the closest thing this post-apocalyptic world has to a celebrity. The newly exhumed and survivors alike stare at us as if our story was already widely known. We hold hands as I steer him back towards my house not thinking twice about it. I don't want to let him out of my sight and with the way he took care of me while he was still infected, I felt it was my turn to care for him.
I was so confused with what was happening around us and for some reason it wasn't Nora or my Dad I wanted to be around. You would think they would provide me the most stability, I had grown up inside these walls with my Dad fighting those infected with the plague and Nora had been my closest friend for years now. But after everything that had happened these past few days, I just wanted to get R somewhere we could be alone.
While we were ensconced in that plane he called home, I had at first felt scared out of my mind. After realizing that he really wasn't going to kill me and eat my brains, I started to relax and have some of the most carefree moments of my teenage life. In the world of today, well of yesterday to be more specific as R had given us hope for a better tomorrow, 19 was not an age of carefree living. Kids couldn't just be kids. We all had responsibilities inside the walled off city of survivors. Once you were in your late teens you were expected to join the security detail, the construction crew, or scavenger parties. The younger kids were taught how to grow food, perform complex maintenance on houses and generators, and how to give standard medical attention.
Now with the corpses beginning to show signs of restored life, I wondered how life would change. Could we go back to how things were before this plague? Could we exhume the world and start restoring the cities and culture?
Part of me worried that it wouldn't be as easy with the other infected as it had been with R and his airport hive. It was as if R's determination to live had shown the others what they could become. I knew we had a dangerous path ahead of us and realized that R and I would have to go out into the dead zones to help exhume the rest of the infected.
All I wanted was to go back to the plane where I didn't have any responsibilities and R took care of all my needs. But again, it was I who needed to take care of him now. I could see he was struggling to hide the pain he was in and as his pace slowed I realized he was still tired. I wondered if he was hungry and if he would be able to keep any food down after not eating human food for who knows how long. I wished I knew how long he had been dead. How had he died? Did he have any family out there? As I concluded we probably wouldn't receive answers to these questions unless he began to recover the memories of his previous life, my hand tightened around his when another question hit me.
What if he had a girlfriend? Or a wife? Or even kids?
Although we hadn't spoken about what was between us, I had begun to assume we were together. I thought of him as a constant in a way I hadn't even thought of Perry as. Nora had joked about R being my 'zombie boyfriend' and I had laughed it off. But in reality she wasn't far off. I did have feelings for R even before his heart began to beat again. I had assumed he cared for me but what if it was just as little more than a friend.
I tried to control my emotions as he turned his head to look at me. He had saved my life. He took care of me and risked his un-life to keep me safe. I wasn't sure who had initiated the kiss in the fountain, but he had defiantly been an active participant. Plus if what she had felt against her stomach during the kiss outside the med-center, what he was feeling wasn't strictly friendly by any means.
"Julie?" R asked with a slight tilt of his head. Although is facial expression didn't change much except for the slight squint of his eyes, I knew he was asking me what was wrong. He had felt my grip tighten around his.
"It's nothing R. Just thinking about what's gonna happen now that you changed"
"Stay, together Julie" R stated. I felt his hand grip mine tighter in the same way I had when we faced down the boneys in the stadium and my dad outside.
I smiled. "Always" I said as we stopped at my door. I haven't heard R say more than a dozen syllables at most, but I find that what he does say is always special and with just those three words I felt myself relax. I shouldn't be worried about how he feels about me. I know that he cares about me and now that we've convinced my dad and the rest of the refugees that the cure is here, I don't have to hide R or my feelings for him.
I remember the last time R and I stood at this door. He had followed me inside the city walls to warn me about the boneys. He risked his life after I had just left him in those suburbs. It wasn't that I had run away from him but I didn't want my dad to find me and kill R permanently.
I lead R inside and helped him up the stairs and into my room. As I helped him lay on the bed, I could hear my father downstairs giving orders to a few of his generals and wanted to go see what the plan was. I also didn't want to leave R.
"Go" R rasped as he caught me glancing at the door and straining to hear the conversation. "I'll be, ok."
"I'll be right back R. I'll bring some soup and crackers up too if I can find them" I tell him as I back out of the room.
R closes his eyes and I see him take a deep breath, something that seems to fascinate me now. I walk down the stairs and into my father's office. He looks up and dismisses his generals with orders to get a few SUVs and supplies ready.
"I'll be leaving tonight Julie. We've decided to drive out to Clark County refugee camp and explain about the cure. We want to pull our resources and spread the word. Spread hope" my dad says to me as he starts to pack up some files and ammunition. He turns to look at me and smiles, "You did a brave thing today, standing up for R against me and the skeletons. I'm sorry I didn't see reason sooner. I'm sorry I shot him."
"I think he'll be ok. He's upstairs sleeping" I tell him.
"Well when I get back in a few days I look forward to meeting him. And we'll have to have a discussion about what's going to happen now" my father gives me a serious look and continues. "I don't know what caused this change, but we're seeing it in the others from R's airport hive. The skeletons aren't changing though. They keep attacking and I'm afraid they're just too gone."
"I think R and I will have to travel hive to hive to show them they could be more. You're probably right about the boneys. It might be too late for them to change back. I'll try talking to R tomorrow about what he thinks happened" I tell him giving him a hug and saying good-bye. I wish him a good trip and he tells me to take care of R. A few minutes later he's leaving the house on his way to Clark County. I grab some supplies and heat up a can of Campbell's soup I find in one of our rations boxes. As I make my way back into my room and place my load on my desk, I look at R. His eyes are open and he's staring at the quotes I have written on my ceiling.
"R, you're covered in dirt and grime," I say giggling. "Why don't I get a bath ready for you? It'll help sooth your muscles too. Here," I had him the soup and crackers I brought up, "Eat a little of this and I'll come get you when it's ready."
"Thank you, Julie" R says in a tired voice. The first time I've heard a clear inflection in his speech. I smile at him and walk into the bathroom as he begins to slurp the soup. I fill the tub with hot water and the last of the bubble bath I had saved from childhood. I was hoping to save it for a special occasion and couldn't think of a better time than now. As I got out a few towels, some rags and soap, I decided that I'd join R in the larger than average tub. While R was taller than the average male, He was also skinny as sin and couldn't see the dimensions of the tub becoming a problem. In fact, after thinking about it, I half wished the tub was smaller.
"Baths ready R," I say as I turn the corner into my room. He's sitting on the bed nibbling on a cracker with the soup only half finished beside him. "How are you feeling? Full?"
He shrugs.
"Come on," I sigh. "Let's get you washed up." He either doesn't realize my intentions to join him or he doesn't realize the significance of the gesture. I'm not nervous about him seeing me in my underwear as I know he was looking when I undressed in the suburbs, but I don't want to embarrass him or force him into an uncomfortable situation.
"Bubbles" R says with a slight smile looking at the tub.
"Yea, I was saving them ever since this whole plague thing started" I tell him as I shut the bathroom door and lead him closer to the tub. "With proof of the cure right here in front of me, I figured this would be a great occasion to use them."
"Uhhhhhh…" my speech seems to have fled me. As I hear Julie shut the bathroom door with her still in the room, I realize that there are an inordinate amount of towels sitting next to the tub for just one person. I realize she intends to join me in the warm fizz of the bubble bath. My mind returns to the kiss we shared outside the med-center and my body's reaction to her passion. I begin to blush again and turn towards Julie.
"Would you rather do this alone?" she asks me not quite meeting my eyes.
"No" I quickly tell her. "Stay together."
Julie smiles at me and stretches up to kiss the corner of my lips. "Let's get these bloody clothes off you."
My heart starts beating faster as her hands slide to the zipper on my hoodie. I pray that I'm able to control my body's reaction to her intimate movements. The zipper sounds like firecrackers to my ears. Loud and startling. Julie carefully pulls the hoodie from shoulders and looks at my face for signs of pain.
"We might have to cut the shirt off. I don't want you to pull the stiches out of your shoulder" Julie says. I can tell she's nervous but my brain can't put together the reasons why. She turns around and grabs a pair of clippers from the sink. As she begins gently cutting the fabric and peeling it away from my body, I can feel her breath on my chest. As amazing as it is now to have actual circulating blood flow, I curse the pounding of my heart as I'm sure she hears it. I feel the blood pumping through my veins and try to stop it but I just can't help redirect the flow from its' intended target. As my jeans get tighter I am surprised by the feel of her hands on my chest. She's tracing the scars that litter my frame and although it hurts I'm thankful when her hand slides over the bullet wound her father gave me. I know she didn't mean to hurt me so I try not to show how much it hurt. As the pain allows me to rein in my arousal she catches the slight grimace on my face.
"Sorry R. We'll have to clean that up a little more to avoid infection" Julie says pulling me by the hand closer to the tub. She kneels down and starts to work on my belt. The vision of her on her knees before me begins to stir my blood again. In a faster movement than I can ever remember having, I raise my hand and brush it over another wound to bring about a flash of pain. Again I'm able to push my passion down. I don't know why but I feel this isn't the right time to let Julie see that side of me. She pulls my jeans down, leaving my boxers on, and helps me to sit in the tub.
I'm not really sure what I should be doing in the the water so I look up at her. My heart pounds in my chest and I'm glad to finally be in the tub and under the cover of the pearly white soap bubbles. Julie already has her shirt off exposing her breasts covered by only a blue scrap of lace she calls a bra. She's working her jeans over her hips and exposing her pink panties covered in little red hearts. I realize I'm staring but can't seem to help it. My eyes are glued to her skin and when she bends over to remove her socks I can't help but rest a hand over the bulge she's inspired in my lap.
Julie gingerly steps into the tub, careful to avoid jostling the water or my outstretched legs too much. She sits on the opposite side of the tub facing me. Her legs are hooked over mine so that her calves are nestled on my thighs. I want to pull her closer and kiss her. I want to wrap her in my arms and hold her tight against my body.
"Ok R, let's get you clean again" Julie says as she dips a rag in the water and squirts some body wash on it. She begins gently rubbing the grim from my shoulders and arms, careful to avoid my injuries. She lets the water run over them to clear any loose dirt. She massages my arm muscles and as I start to relax I close my eyes. She gives my chest the same movement then my sides. Next she starts on my calves and moves up my thighs, sloshing the water around as she gets closer to me on her knees. I'm so relaxed it's with a jolt I realize she's getting closer to my lap and my reaction to her ministrations. I try to catch her wrists to stop her but I'm too slow. She brushes the rag over my hip bone and feels the tent my erection made of the boxers against her arm. She stops and stiffens for a moment before looking to my eyes with a surprised expression.
"I'm sorry" I say ineffectually. I don't know what I'm sorry about but I feel embarrassed.
"It's ok R" Julie smiles at me. "We're together yea?"
"Always" I say repeating her words from just an hour earlier. She sits back with her thighs now over mine and reaches up to place one hand gently over my heart and the wound her father had given me. She looks into my eyes as she feels its steady beating, and then pulls my head down to kiss my lips. As I begin to deepen the kiss her tongue slides into my mouth to explore. I place one hand on the back of her neck, tangled in her hair to keep her mouth on mine, and the other hand on her waist urging her closer.
She drops the rag into the water with a slight splash and runs her hand down my stomach and into my boxers to grip my shaft in her fist. As she slowly begins to move my speech seems to revert back to when I was infected. I can get out little more than grunts and moans in response to the pleasure I feel. Julie doesn't seem to care as she kisses down my neck then up to nibble on my earlobe. Her breath is hot in my ear and my mouth forms an 'o' as her hands cup my balls.
"Julie" I gasp as my hand falls from her hair to find her breast. With the hand not busy pleasuring me, she covers my hand and begins to knead her breast with my hand. In a flash she un-hooks her bra and lets it slide into the tub. I open my eyes to look down at her heaving chest and moan as a feel a tightening in my ball sack. Her breasts dip in and out of the water as her hand slides up and down. I place both hands on her breasts and slide my thumbs over her pebbled nipples. She moans and the sound goes straight to my dick. With a grunt my body relaxes and I soften in Julies' hand.
She kisses me one last time then reaches out of the tub for a towel. She stands up and wraps it around herself before grabbing one for me. I wrap it around myself and let my soaking boxers fall from beneath. "Come on," she smirks, "let's go to bed."
I smile and stand up to follow her. She grabs my hand and leads me to sit on her bed before looking around the room.
"I just realized I don't have any clothes that will fit you. I'll have to ask Nora to bring some stuff from the thrift place tomorrow" Julie says blushing a little. I don't know how she can blush after what we just did but it causes a faint pinkening of my cheeks as well. I reach out for her and when she places her hand in mine I pull her down onto the bed with me, removing her towel and mine in the process.
Our naked bodies are pressed together in her small twin bed and as I pull the quilt over us I kiss her forehead.
"Stay together" I whisper in her ear as she snuggles closer. She smiles up at me as she wraps an arm around my side and rests her head on my uninjured shoulder. I realize the pain has all but left my body and am thankful when I finally get what I've been longing for since watching her sleep on the floor of the plane. Julie falling asleep in my arms.


text:
Just started watching Hoodwinkee's last "Friday Live", where the great news have been announced...
The guy behind Bring a Loupe, a weekly fest of rancid hype, and the mastermind of the redial-and-frankenwatch-selling fleecer's den called the Hodinkee Shop, Louis, is no longer with Hoodwinkee. That being only weeks after the Donkeys have sold another franken! Coincidence, or justice?
For two weeks, there hasn't been a Bring a Loupe, which means two weeks of peace for the vintage watch market.
And only yesterday, there's this announcement...
I wonder if that's a coincidence, or could it be, that after months of heavy Bring a Brain barrage at WUS (with thousands of views - BaB XIV alone got north of 5600!), my wee crusade has finally brought some results?
I dearly hope, that whoever the successor to Louis might be, won't do the same thing, or at least will know certain limits on open lies and cons at the site (pronounce the S the Sean Connery way) and the Shop. Yes, sadly Hoodwinkee wants to continue Bring a Loupe, the piece to which Bring a Brain owes its name. I would find it odd if they didn't.
May I only announce this: should this be a sign of Hoodwinkee improving, there will be less Bring a Brains coming, since I only publish these when it's necessary, when shit hits the fan, and the community turns a blind eye, because "hey, it's Hodinkee, and they can't be wrong."
But to Jove I swear, that should it get worse, Bring a Brain shall give the Donkeys no quarter. If so, it will appear regularly, the bombardment will be heavier than ever, and the show will go on, presented to you by yours truly, in the best possible way- the Bring a Brain way.
Fare thee well and good riddance, Louis, I'm glad that thou no longer art in the business of fleecing, lies and hype. Go collecting like we do, experience the shit you've been fueling for so long, that fucking inferno that you've been putting out with high-octane bloody gasoline.
Meanwhile, we - we the WIS community - can enjoy the (hopefully not particularly) short period of peace.
End of communique.

subset: commoncrawl


text:
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D-Link DSL-2750U Wireless N 300 Router, Input Type RJ-11 (Telephone Line) supported by ISPs such as MTNL, BSNL, Airtel,Reliance Communication and Tata Indicom. Not compatible with cable broadband ISPs such as Hathway, ACT, Tikona, MyWorld, Nextra, Siti Cable, You Broadband, Spectranet etc Fast Internet transmission of up to 24 Mbps downstream, 1 Mbps upstream. Wireless speed: up to 54 Mbps (802.11g), 300 Mbps (802.11n)1. A wireless ON and OFF button is also included for user convenience. Device Interface: RJ-11 ADSL port, WPS button, Power on/off switch, Built-in 802.11n Wireless Lan and two 5 dbi antennas.
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text:
Play Golf AmarilloHome PlayGolf
Most Requested
Sherwin Cox
Head Golf Professional
DOB: October 20, 1950
Sherwin has been a PGA member since 1976. He began his golf career in 1971 as an Assistant Golf Professional at Pampa Country Club then moved to Amarillo in 1976 to work at Tascosa Country Club also as an Assistant. In 1980 he took the Head Professional position at Canyon Country Club before moving to Ross Rogers Golf Course January 1, 1981. Sherwin has completed 31 years of service to the City of Amarillo and the Amarillo Area golfing public. He has worked closely with Amarillo PGA Professionals, the media, tournament sponsors and amateurs to establish one of the strongest Amateur Tournament Programs in the country. Sherwin has been actively involved in the PGA for the past 36 years and has attended 24 National PGA Annual Meetings as a delegate. He along with Royal Oaks Country Club Professional Randy Smith of Dallas provided the influence behind the PGA of America establishing a National Junior Tour in 1996 that resulted in Sherwin being named National Junior Golf Leader.
Honors, Awards, Offices, and Committees
Northern Texas PGA
- 1988 Professional of the Year
- 1981, 1986, 2004 Merchandiser of the Year-Public
- 1992 Horton Smith Award
- 1993, 1994, 1995, 1996 Junior Golf Leader
- 2002 Quarter Century Club
- 1990 Section Liaison Amarillo Open-Ben Hogan Tour Event
- 1980-92,1996-1999 Section Board of Directors
- 1986-87 President
- 1985 Vice President
- Junior Golf Chairman
- Junior Golf Committee
- Membership Committee
- Education Committee
National PGA
- 1996 National Junior Golf Leader
- 1986 Merchandiser of the Year-Public
- National Junior Golf Committee
- National Education Committee
- National Awards Committee
West Texas Chapter PGA
- 1984 Professional of the Year
- 1992-93 Junior Golf Leader
- 1981,1986,1998 Merchandiser of the Year-Public
- 1993,1996 Bill Strausebaugh Award
- 1992 Horton Smith Award
- 1982-83 President
- 1981 Secretary-Treasurer
- Education Chairman
- Junior Golf Chairman
Other Awards
- 1988, 1989, 1990, 1991, 1992, & 1999 -100 Best Golf Shops in America as presented by Golf Shop Operations Magazine
- 1994 All-Pro Team – for Promotions as presented by Golf Pro Magazine
- 1989 Golf Coach of the Year-Panhandle Sports Hall of Fame
- Jenny, Wife 40 Years
- Ty, Son
- Teela Miesner, Daughter
- Marty Miesner, Son-in-Law
- Tucker Thomas Miesner, Grandson
- Hudson Deam Miesner, Grandson
James Stow
Golf Course Superintendent
DOB: September 10, 1982
James began his golf course maintenance career at the age of 13 at Oldham County Club and then as a seasonal worker at John Pitman in Hereford while in high school. He knew then that a Golf Course Superintendent was his career choice due to a love for the game and the reward of participating in the maintenance and detail of a golf course operation. Out of high school James went to Arizona and was hired as a spray tech /foreman at a 36 hole facility Superstition Mountain Golf and Country Club. During his time there he participated in preparing for Senior Tour major and the Senior Slam. While he was in Arizona he began his education in Professional Golf Turf Management from Rutgers University. James has been a golf course Superintendent ever since with most of his stint being in the Phoenix, Az. During his career as a Superintendent he has provided high-quality playing surfaces to a wide spectrum of golf enthusiasts including daily fee guests as well as ultra high-end private memberships. James has been married to his high school sweetheart (Tessa) since 2001. They have 2 beautiful children Taytum (daughter) and Kyler (son). He has been with the City of Amarillo @ Ross Rogers since February of 2011.
Pro-Shop Attendants
- Justin Lamberson
- Michael Sanchez
- Jared Miller
- Bill Smith
- Jordan Burkham
- Eric Frost
- James Downs
- Clay Lankford
- Brayden Cruth


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Building the Birding Community in New York's Hudson Mohawk Region
Do not use this form if you want to join the club for the first time. Instead, join here..
You must be registered on hmbc.net to pay your dues on-line. Register Here.
This is the first of three steps:
Dues at the Active, Sustaining and Life levels are a fixed amount per household, regardless of the number of persons.
Student memberships are for individuals not multiperson households.


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DAWG Working with EPWE?
Our office leak has informed us, that DAWG owner Dr. Lawrence Zirconium has entered into negotiations with the Championship Committee of Eastern Pennsylvania Wrestling Entertainment to bring the Dangerous Adrenaline Wrestling Gladiators top stars to a future EPWE Underground Event.
Professional Wrestling kicked into #Overdrive! — with Jonathan Padilla, Anthony Gangone, Sebastian Cruz, Sonjay Dutt, Alex Reyes, Tim Donst, Ricky Reyes, Panda Man, Marq Quen and Steve Off.
Leave a Reply.
June 2018


text: That's interesting thanks Doug, I will have to give it another shot. So Doug, what do you think about this whole St. Bonaventure thing :-) Mark Fugatt MCT, MCSE, Microsoft Exchange MVP Pentech Office Solutions Inc Rochester, NY Tel: 585 586 3890 Fax: 585 249 0316 www.4mcts.com www.exchangetrainer.com -----Original Message----- From: Stelley, Doug [mailto:DStelley@xxxxxxx] Sent: Monday, March 10, 2003 12:23 PM To: [ExchangeList] http://www.MSExchange.org/ Weird, I know, but it worked :-) (I also installed the .net on as well) Doug Stelley Asst. Network Administrator Olean General Hospital (716) 375-7320


text:
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Porting to Legals
Wednesday, October 25, 2006 at 9:50PM
In a post on the Open Laszlo forums, rcyeager of cooqy described his experience trying his Open Laszlo applications in the latest preview release, PR4:
The demos in the PR4 Explorer work...but my "real-world" code fails miserably. I expected DHTML conversion issues, but to lose support of SWF mode compatibility is scary...and this is with Legals supposedly going to Beta soon? In my case, 100% of my V3 apps don't work in either SWF mode or DHTML w/ Legals PR4. Is anyone getting better results with their real-world V3 apps running in Legals?? So far the attempt by Legals to pull the tablecloth out from under the dishes has left my lobster dinner strewn all across the floor...
Jim Grandy's post about Legals Preview Release 3 sets the stage. My perspective on porting existing applications to the multiple runtimes infrastructure is based on converting the calendar demo. A few highlights:
- swf assets won't work in DHTML. To display a swf asset, you'd need the flash player; we're not using the flash player in DHTML, so, swf assets just won't appear. The solution here is to use bitmap assets instead of swf's.
- We haven't made all the components work yet in PR4. We've got open bugs in JIRA for all the component problems.
- drawview support was just added in the last few days; it's not in PR4. Look for it in beta 1, at least for firefox. (IE support is still in progress, I think.)
- DHTML doesn't support embedding fonts; swf does. If you try to embed a font, you'll get a compile warning, and the text will look ugly, or it won't appear at all.
- The flash runtime is permissive about derefrencing a null reference and getting properties on an undefined object. DHTML blows up if you do this.Because it was permitted in swf, lots of code doesn't check for null. All the places that don't check for null need to be tracked down and fixed, both in the LFC, the components, and application code. This was the source of at least half of the problems I had.


text: Dr. Hansen is board certified in urology. He attended medical school at the University of Chicago and completed a residency in general surgery and urology at University of New Mexico School of Medicine in Albuquerque, N.M. He has performed hundreds of surgeries with the da Vinci S™ HD Surgical System, cutting his patients' recovery times and improving their outcomes. He practices at Central Wyoming Urological Associates in Casper.


text: As all small business owners know, achieving growth is critical to business success over the long term. But you may be asking yourself, what are the best growth strategies and how can I implement them to truly see progress? We've outlined several tips that we think are surefire ways to help you make the most out of the business opportunities that await you in 2018. Below are four tips. To get all nine tips, download the complete ebook here.


text:
Detmar Meurers
dm at julius.ling.ohio-state.edu
Sat Jun 3 14:36:00 EDT 2006
Hi, I'm using mod_python's publisher handler to load a .py file using the usual AddHandler python-program .py PythonHandler mod_python.publisher PythonDebug On .htaccess specification in the directory in which the .py file resides. That .py file imports some other modules, both standard ones and some auxiliary functions I wrote and put into a separate file. Usually the code executes fine, but every five or so times the page is loaded (without changing anything, e.g. just doing several reloads in a row), I get the error that mod_python for some reason cannot find one of the modules that is being imported (namely the file with the auxiliary functions, called tagarela_util.py, which is in the same directory). I'm including an example error message below. This error never seems to appear for the standard modules I import, (or when I put that file into the python2.4/site-packages which is in sys.path), so I suspect that it has something to do with the way mod_python seems to use the .htaccess files to determine which directory to add to the sys.path? I very much hope someone can explain this erratic behavior and how I can fix it - as it stands the only way I found to avoid these occasional errors arising when importing modules is to put everything into the same file, i.e. to avoid importing modules, which naturally leads to massive code duplication and non-modularity. Any suggestions would be much appreciated! Best, Detmar -- Detmar Meurers, Associate Professor, Dept. of Linguistics, OSU 201a Oxley Hall, 1712 Neil Avenue, Columbus OH 43210-1298, USA http://ling.osu.edu/~dm/ GnuPG key on web page ****Server used: 'SERVER_SOFTWARE': 'Apache/2.2.0 (Unix) mod_ssl/2.2.0 OpenSSL/0.9.8a DAV/2 mod_python/3.2.8 Python/2.4.2' (Errors appears with a variety of browsers, so seems to be independent of that.) ****Error message: Mod_python error: "PythonHandler mod_python.publisher" Traceback (most recent call last): File "/opt/local/lib/python2.4/site-packages/mod_python/apache.py", line 299, in HandlerDispatch result = object(req) File "/opt/local/lib/python2.4/site-packages/mod_python/publisher.py", line 204, in handler module = page_cache[req] File "/opt/local/lib/python2.4/site-packages/mod_python/cache.py", line 82, in __getitem__ return self._checkitem(name)[2] File "/opt/local/lib/python2.4/site-packages/mod_python/cache.py", line 124, in _checkitem value = self.build(key, name, opened, entry) File "/opt/local/lib/python2.4/site-packages/mod_python/publisher.py", line 77, in build return ModuleCache.build(self, key, req, opened, entry) File "/opt/local/lib/python2.4/site-packages/mod_python/cache.py", line 371, in build exec opened in module.__dict__ File "/home/dm/public_html/icall/tagarela/activities/Reading/index.py", line 3, in ? from tagarela_util import _get_session, _file2string ImportError: No module named tagarela_util


text:
Logix Blossom Zest Noida Expressway Sector 143 Price List with Floor Plan and Area Layout
|Studio Apartment (1BHK)
|470 sqft
|BSP : 23 lakhs (Rs. 3500/sqft)
|2 Bedroom + 2 Toilet
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|2 Bedroom + 2 Toilet
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Get 2BHK in Logix Blossom Zest @ Rs. 4100/sqft.
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|Studio Apartment , Area : 470 sqft
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text:
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text:
In Case You Missed: Worcester Restaurant Health Inspection Tracker
Saturday, September 14, 2013
INTERACTIVE Worcester Restaurant Health Inspection Tracker
Before you go out to dinner, what do you know about the cleanliness of the establishment?
GoLocalWorcester spent weeks going through the files of every health inspection in Worcester for nearly 700 restaurants, to report on health code violations in a series of stories. Now, this week GoLocal introduced a new, proprietary interactive map to check any restaurant before you go out to eat.
To check out GoLocalWorcester's Restaurant Health Inspection Tracker, go here.
To review the 50 restaurants with the worst health code scores in Worcester, go here.
Related Articles
- 50 Restaurants with Worst Health Code Scores in Worcester
- Experts Weigh in on Restaurant Inspections and Foodborne Illness
- INTERACTIVE: Worcester Restaurant Health Inspection Tracker
- Worcester Restaurant Inspections: How the Fast Food Chains Scored
- Worcester Restaurant Inspections: Lukes Calls for Letter Grades


text:
Fiery Lagos cleric and Pastor of Latter Rain Assembly Tunde Bakare has revealed that most political juggernauts in Nigeria politics will fall at the feet of women in 2018.
He said this during the early hour sermon at his church auditorium Monday morning, adding that the prophecy would come to pass to save the country from ruin.
Bakare did not mention names, he reminded the congregation how he predicted the death of a military head of state in the arms of two women in 1998 that came to pass.
He stated that those that were seen as the political superpower in Nigeria would be replaced and that God would raise new armies to direct the affairs of the country.
Bakare, a one-time vice presidential candidate to President Muhammadu Buhari said that God had revealed to him to contest for the presidential position.
He stated that though God did not tell him when to run for such position, he would make it public whenever the almighty does so.
The pastor of Latter Rain Assembly declared that 2018 would be a year when women would break stumbling blocks in most fields of human endeavours both in Nigeria and other countries.


text:
Articles by Brandon J. Henderson
Other Publications (16)
- The Journal of Pharmacology and Experimental Therapeutics
- The Journal of Pharmacology and Experimental Therapeutics
- PloS One
- Journal of Medicinal Chemistry
- ACS Medicinal Chemistry Letters
- Bioorganic & Medicinal Chemistry Letters
- ACS Chemical Neuroscience
- Bioorganic & Medicinal Chemistry
- The Journal of General Physiology
- Pharmacological Research
- The Journal of Biological Chemistry
- Neuropharmacology
- The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
- The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
- The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
- PloS One
Articles by Brandon J. Henderson in JoVE
Utilizing pHluorin-tagged Receptors to Monitor Subcellular Localization and Trafficking Ashley M. Fox-Loe1, Brandon J. Henderson2, Christopher I. Richards1 1Department of Chemistry, University of Kentucky, 2Department of Biomedical Sciences, Marshall University Labeling the extracellular domain of a membrane protein with a pH sensitive fluorophore, superecliptic pHluorin (SEP), allows subcellular localization, expression, and trafficking to be determined. Imaging SEP-labeled proteins with total internal reflection fluorescence microscopy (TIRFM) enables the quantification of protein levels in the peripheral ER and plasma membrane.
Other articles by Brandon J. Henderson on PubMed
Effect of Novel Negative Allosteric Modulators of Neuronal Nicotinic Receptors on Cells Expressing Native and Recombinant Nicotinic Receptors: Implications for Drug Discovery The Journal of Pharmacology and Experimental Therapeutics. Feb, 2009 | Pubmed ID: 18984653 Allosteric modulation of nAChRs is considered to be one of the most promising approaches for drug design targeting nicotinic acetylcholine receptors (nAChRs). We have reported previously on the pharmacological activity of several compounds that seem to act noncompetitively to inhibit the activation of alpha3beta4(*) nAChRs. In this study, the effects of 51 structurally similar molecules on native and recombinant alpha3beta4 nAChRs are characterized. These 51 molecules inhibited adrenal neurosecretion activated via stimulation of native alpha3beta4(*) nAChR, with IC(50) values ranging from 0.4 to 13.0 microM. Using cells expressing recombinant alpha3beta4 nAChRs, these molecules inhibited calcium accumulation (a more direct assay to establish nAChR activity), with IC(50) values ranging from 0.7 to 38.2 microM. Radiolabeled nAChR binding studies to orthosteric sites showed no inhibitory activity on either native or recombinant nAChRs. Correlation analyses of the data from both functional assays suggested additional, non-nAChR activity of the molecules. To test this hypothesis, the effects of the drugs on neurosecretion stimulated through non-nAChR mechanisms were investigated; inhibitory effects ranged from no inhibition to 95% inhibition at concentrations of 10 microM. Correlation analyses of the functional data confirmed this hypothesis. Several of the molecules (24/51) increased agonist binding to native nAChRs, supporting allosteric interactions with nAChRs. Computational modeling and blind docking identified a binding site for our negative allosteric modulators near the orthosteric binding site of the receptor. In summary, this study identified several molecules for potential development as negative allosteric modulators and documented the importance of multiple screening assays for nAChR drug discovery.
Negative Allosteric Modulators That Target Human Alpha4beta2 Neuronal Nicotinic Receptors The Journal of Pharmacology and Experimental Therapeutics. Sep, 2010 | Pubmed ID: 20551292 Allosteric modulation of neuronal nicotinic acetylcholine receptors (nAChRs) is considered to be one of the most promising approaches for therapeutics. We have previously reported on the pharmacological activity of several compounds that act as negative allosteric modulators (NAMs) of nAChRs. In the following studies, the effects of 30 NAMs from our small chemical library on both human alpha4beta2 (Halpha4beta2) and human alpha3beta4 (Halpha3beta4) nAChRs expressed in human embryonic kidney ts201 cells were investigated. During calcium accumulation assays, these NAMs inhibited nAChR activation with IC(50) values ranging from 2.4 microM to more than 100 microM. Several NAMs showed relative selectivity for Halpha4beta2 nAChRs with IC(50) values in the low micromolar range. A lead molecule, KAB-18, was identified that shows relative selectivity for Halpha4beta2 nAChRs. This molecule contains three phenyl rings, one piperidine ring, and one ester bond linkage. Structure-activity relationship (SAR) analyses of our data revealed three regions of KAB-18 that contribute to its relative selectivity. Predictive three-dimensional quantitative SAR (comparative molecular field analysis and comparative molecular similarity indices analysis) models were generated from these data, and a pharmacophore model was constructed to determine the chemical features that are important for biological activity. Using docking approaches and molecular dynamics on a Halpha4beta2 nAChR homology model, a binding mode for KAB-18 at the alpha/beta subunit interface that corresponds to the predicted pharmacophore is described. This binding mode was supported by mutagenesis studies. In summary, these studies highlight the importance of SAR, computational, and molecular biology approaches for the design and synthesis of potent and selective antagonists targeting specific nAChR subtypes.
Identification of a Negative Allosteric Site on Human α4β2 and α3β4 Neuronal Nicotinic Acetylcholine Receptors PloS One. 2011 | Pubmed ID: 21949802 Acetylcholine-based neurotransmission is regulated by cationic, ligand-gated ion channels called nicotinic acetylcholine receptors (nAChRs). These receptors have been linked to numerous neurological diseases and disorders such as Alzheimer's disease, Parkinson's disease, and nicotine addiction. Recently, a class of compounds has been discovered that antagonize nAChR function in an allosteric fashion. Models of human α4β2 and α3β4 nicotinic acetylcholine receptor (nAChR) extracellular domains have been developed to computationally explore the binding of these compounds, including the dynamics and free energy changes associated with ligand binding. Through a blind docking study to multiple receptor conformations, the models were used to determine a putative binding mode for the negative allosteric modulators. This mode, in close proximity to the agonist binding site, is presented in addition to a hypothetical mode of antagonism that involves obstruction of C loop closure. Molecular dynamics simulations and MM-PBSA free energy of binding calculations were used as computational validation of the predicted binding mode, while functional assays on wild-type and mutated receptors provided experimental support. Based on the proposed binding mode, two residues on the β2 subunit were independently mutated to the corresponding residues found on the β4 subunit. The T58K mutation resulted in an eight-fold decrease in the potency of KAB-18, a compound that exhibits preferential antagonism for human α4β2 over α3β4 nAChRs, while the F118L mutation resulted in a loss of inhibitory activity for KAB-18 at concentrations up to 100 µM. These results demonstrate the selectivity of KAB-18 for human α4β2 nAChRs and validate the methods used for identifying the nAChR modulator binding site. Exploitation of this site may lead to the development of more potent and subtype-selective nAChR antagonists which may be used in the treatment of a number of neurological diseases and disorders.
Structure-activity Relationship Studies of Sulfonylpiperazine Analogues As Novel Negative Allosteric Modulators of Human Neuronal Nicotinic Receptors Journal of Medicinal Chemistry. Dec, 2011 | Pubmed ID: 22060139 Neuronal nicotinic receptors have been implicated in several diseases and disorders such as autism, Alzheimer's disease, Parkinson's disease, epilepsy, and various forms of addiction. To understand the role of nicotinic receptors in these conditions, it would be beneficial to have selective molecules that target specific nicotinic receptors in vitro and in vivo. Our laboratory has previously identified novel negative allosteric modulators of human α4β2 (Hα4β2) and human α3β4 (Hα3β4) nicotinic receptors. The effects of novel sulfonylpiperazine analogues that act as negative allosteric modulators on both Hα4β2 nAChRs and Hα3β4 nAChRs were investigated. This work, through structure-activity relationship (SAR) studies, describes the chemical features of these molecules that are important for both potency and selectivity on Hα4β2 nAChRs.
Discovery of Novel α4β2 Neuronal Nicotinic Receptor Modulators Through Structure-Based Virtual Screening ACS Medicinal Chemistry Letters. Nov, 2011 | Pubmed ID: 24936233 We performed a hierarchical structure-based virtual screening utilizing a comparative model of the human α4β2 neuronal nicotinic acetylcholine receptor (nAChR) extracellular domain. Compounds were selected for experimental testing based on structural diversity, binding pocket location, and standard error of the free energy scoring function used in the screening. Four of the eleven in silico hit compounds showed promising activity with low micromolar IC50 values in a calcium accumulation assay. Two of the antagonists were also proven to be selective for human α4β2 vs human α3β4 nAChRs. This is the first report of successful discovery of novel nAChR antagonists through the use of structure-based virtual screening with a human nAChR homology model. These compounds may serve as potential novel scaffolds for further development of selective nAChR antagonists.
3D-QSAR and 3D-QSSR Models of Negative Allosteric Modulators Facilitate the Design of a Novel Selective Antagonist of Human α4β2 Neuronal Nicotinic Acetylcholine Receptors Bioorganic & Medicinal Chemistry Letters. Feb, 2012 | Pubmed ID: 22285942 Subtype selective molecules for α4β2 neuronal nicotinic acetylcholine receptors (nAChRs) have been sought as novel therapeutics for nicotine cessation. α4β2 nAChRs have been shown to be involved in mediating the addictive properties of nicotine while other subtypes (i.e., α3β4 and α7) are believed to mediate the undesired effects of potential CNS drugs. To obtain selective molecules, it is important to understand the physiochemical features of ligands that affect selectivity and potency on nAChR subtypes. Here we present novel QSAR/QSSR models for negative allosteric modulators of human α4β2 nAChRs and human α3β4 nAChRs. These models support previous homology model and site-directed mutagenesis studies that suggest a novel mechanism of antagonism. Additionally, information from the models presented in this work was used to synthesize novel molecules; which subsequently led to the discovery of a new selective antagonist of human α4β2 nAChRs.
Defining the Putative Inhibitory Site for a Selective Negative Allosteric Modulator of Human α4β2 Neuronal Nicotinic Receptors ACS Chemical Neuroscience. Sep, 2012 | Pubmed ID: 23019495 Neuronal nicotinic receptors (nAChRs) have been implicated in several diseases and disorders such as autism spectrum disorders, Alzheimer's disease, Parkinson's disease, epilepsy, and nicotine addiction. To understand the role of nAChRs in these conditions, it would be beneficial to have selective molecules that target specific nAChRs in vitro and in vivo. Our laboratory has previously identified a novel allosteric site on human α4β2 nAChRs using a series of computational and in vitro approaches. At this site, we have identified negative allosteric modulators that selectively inhibit human α4β2 nAChRs, a subtype implicated in nicotine addiction. This study characterizes the allosteric site via site-directed mutagenesis. Three amino acids (Phe118, Glu60, and Thr58) on the β2 subunit were shown to participate in the inhibitory properties of the selective antagonist KAB-18 and provided insights into its antagonism of human α4β2 nAChRs. SAR studies with KAB-18 analogues and various mutant α4β2 nAChRs also provided information concerning how different physiochemical features influence the inhibition of nAChRs through this allosteric site. Together, these studies identify the amino acids that contribute to the selective antagonism of human α4β2 nAChRs at this allosteric site. Finally, these studies define the physiochemical features of ligands that influence interaction with specific amino acids in this allosteric site.
Discovery of Benzamide Analogs As Negative Allosteric Modulators of Human Neuronal Nicotinic Receptors: Pharmacophore Modeling and Structure-activity Relationship Studies Bioorganic & Medicinal Chemistry. Aug, 2013 | Pubmed ID: 23757208 The present study describes our ongoing efforts toward the discovery of drugs that selectively target nAChR subtypes. We exploited knowledge on nAChR ligands and their binding site that were previously identified by our laboratory through virtual screenings and identified benzamide analogs as a novel chemical class of neuronal nicotinic receptor (nAChR) ligands. The lead molecule, compound 1 (4-(allyloxy)-N-(6-methylpyridin-2-yl)benzamide) inhibits nAChR activity with an IC₅₀ value of 6.0 (3.4-10.6) μM on human α4β2 nAChRs with a ∼5-fold preference against human α3β4 nAChRs. Twenty-six analogs of compound 1 were also either synthesized or purchased for structure-activity relationship (SAR) studies and provided information relating the chemical/structural properties of the molecules to their ability to inhibit nAChR activity. The discovery of subtype-selective ligands of nAChRs described here should contribute significantly to our understanding of the involvement of specific nAChR subtypes in normal and pathophysiological states.
Nicotine Exploits a COPI-mediated Process for Chaperone-mediated Up-regulation of Its Receptors The Journal of General Physiology. Jan, 2014 | Pubmed ID: 24378908 Chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nAChRs) in the brain. This up-regulation partially underlies addiction and may also contribute to protection against Parkinson's disease. nAChRs containing the α6 subunit (α6* nAChRs) are expressed in neurons in several brain regions, but comparatively little is known about the effect of chronic nicotine on these nAChRs. We report here that nicotine up-regulates α6* nAChRs in several mouse brain regions (substantia nigra pars compacta, ventral tegmental area, medial habenula, and superior colliculus) and in neuroblastoma 2a cells. We present evidence that a coat protein complex I (COPI)-mediated process mediates this up-regulation of α6* or α4* nAChRs but does not participate in basal trafficking. We show that α6β2β3 nAChR up-regulation is prevented by mutating a putative COPI-binding motif in the β3 subunit or by inhibiting COPI. Similarly, a COPI-dependent process is required for up-regulation of α4β2 nAChRs by chronic nicotine but not for basal trafficking. Mutation of the putative COPI-binding motif or inhibition of COPI also results in reduced normalized Förster resonance energy transfer between α6β2β3 nAChRs and εCOP subunits. The discovery that nicotine exploits a COPI-dependent process to chaperone high sensitivity nAChRs is novel and suggests that this may be a common mechanism in the up-regulation of nAChRs in response to chronic nicotine.
Pharmacological Chaperoning of NAChRs: a Therapeutic Target for Parkinson's Disease Pharmacological Research. May, 2014 | Pubmed ID: 24593907 Chronic exposure to nicotine results in an upregulation of neuronal nicotinic acetylcholine receptors (nAChRs) at the cellular plasma membrane. nAChR upregulation occurs via nicotine-mediated pharmacological receptor chaperoning and is thought to contribute to the addictive properties of tobacco as well as relapse following smoking cessation. At the subcellular level, pharmacological chaperoning by nicotine and nicotinic ligands causes profound changes in the structure and function of the endoplasmic reticulum (ER), ER exit sites, the Golgi apparatus and secretory vesicles of cells. Chaperoning-induced changes in cell physiology exert an overall inhibitory effect on the ER stress/unfolded protein response. Cell autonomous factors such as the repertoire of nAChR subtypes expressed by neurons and the pharmacological properties of nicotinic ligands (full or partial agonist versus competitive antagonist) govern the efficiency of receptor chaperoning and upregulation. Together, these findings are beginning to pave the way for developing pharmacological chaperones to treat Parkinson's disease and nicotine addiction.
Lynx1 Shifts α4β2 Nicotinic Receptor Subunit Stoichiometry by Affecting Assembly in the Endoplasmic Reticulum The Journal of Biological Chemistry. Nov, 2014 | Pubmed ID: 25193667 Glycosylphosphatidylinositol-anchored neurotoxin-like receptor binding proteins, such as lynx modulators, are topologically positioned to exert pharmacological effects by binding to the extracellular portion of nAChRs. These actions are generally thought to proceed when both lynx and the nAChRs are on the plasma membrane. Here, we demonstrate that lynx1 also exerts effects on α4β2 nAChRs within the endoplasmic reticulum. Lynx1 affects assembly of nascent α4 and β2 subunits and alters the stoichiometry of the receptor population that reaches the plasma membrane. Additionally, these data suggest that lynx1 shifts nAChR stoichiometry to low sensitivity (α4)3(β2)2 pentamers primarily through this interaction in the endoplasmic reticulum, rather than solely via direct modulation of activity on the plasma membrane. To our knowledge, these data represent the first test of the hypothesis that a lynx family member, or indeed any glycosylphosphatidylinositol-anchored protein, could act within the cell to alter assembly of a multisubunit protein.
Inside-out Neuropharmacology of Nicotinic Drugs Neuropharmacology. Sep, 2015 | Pubmed ID: 25660637 Upregulation of neuronal nicotinic acetylcholine receptors (AChRs) is a venerable result of chronic exposure to nicotine; but it is one of several consequences of pharmacological chaperoning by nicotine and by some other nicotinic ligands, especially agonists. Nicotinic ligands permeate through cell membranes, bind to immature AChR oligomers, elicit incompletely understood conformational reorganizations, increase the interaction between adjacent AChR subunits, and enhance the maturation process toward stable AChR pentamers. These changes and stabilizations in turn lead to increases in both anterograde and retrograde traffic within the early secretory pathway. In addition to the eventual upregulation of AChRs at the plasma membrane, other effects of pharmacological chaperoning include modifications to endoplasmic reticulum stress and to the unfolded protein response. Because these processes depend on pharmacological chaperoning within intracellular organelles, we group them as "inside-out pharmacology". This term contrasts with the better-known, acute, "outside-in" effects of activating and desensitizing plasma membrane AChRs. We review current knowledge concerning the mechanisms and consequences of inside-out pharmacology. This article is part of the Special Issue entitled 'The Nicotinic Acetylcholine Receptor: From Molecular Biology to Cognition'.
Nicotinic Receptor Subtype-selective Circuit Patterns in the Subthalamic Nucleus The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2015 | Pubmed ID: 25740504 The glutamatergic subthalamic nucleus (STN) exerts control over motor output through nuclei of the basal ganglia. High-frequency electrical stimuli in the STN effectively alleviate motor symptoms in movement disorders, and cholinergic stimulation boosts this effect. To gain knowledge about the mechanisms of cholinergic modulation in the STN, we studied cellular and circuit aspects of nicotinic acetylcholine receptors (nAChRs) in mouse STN. We discovered two largely divergent microcircuits in the STN; these are regulated in part by either α4β2 or α7 nAChRs. STN neurons containing α4β2 nAChRs (α4β2 neurons) received more glutamatergic inputs, and preferentially innervated GABAergic neurons in the substantia nigra pars reticulata. In contrast, STN neurons containing α7 nAChRs (α7 neurons) received more GABAergic inputs, and preferentially innervated dopaminergic neurons in the substantia nigra pars compacta. Interestingly, local electrical stimuli excited a majority (79%) of α4β2 neurons but exerted strong inhibition in 58% of α7 neurons, indicating an additional diversity of STN neurons: responses to electrical stimulation. Chronic exposure to nicotine selectively affects α4β2 nAChRs in STN: this treatment increased the number of α4β2 neurons, upregulated α4-containing nAChR number and sensitivity, and enhanced the basal firing rate of α4β2 neurons both ex vivo and in vivo. Thus, chronic nicotine enhances the function of the microcircuit involving α4β2 nAChRs. This indicates chronic exposure to nicotinic agonist as a potential pharmacological intervention to alter selectively the balance between these two microcircuits, and may provide a means to inhibit substantia nigra dopaminergic neurons.
Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2016 | Pubmed ID: 26740650 Retrospective epidemiological studies show an inverse correlation between susceptibility to Parkinson's disease and a person's history of tobacco use. Animal model studies suggest nicotine as a neuroprotective agent and nicotinic acetylcholine (ACh) receptors (nAChRs) as targets for neuroprotection, but the underlying neuroprotective mechanism(s) are unknown. We cultured mouse ventral midbrain neurons for 3 weeks. Ten to 20% of neurons were dopaminergic (DA), revealed by tyrosine hydroxylase (TH) immunoreactivity. We evoked mild endoplasmic reticulum (ER) stress with tunicamycin (Tu), producing modest increases in the level of nuclear ATF6, phosphorylated eukaryotic initiation factor 2α, nuclear XBP1, and the downstream proapoptotic effector nuclear C/EBP homologous protein. We incubated cultures for 2 weeks with 200 nm nicotine, the approximate steady-state concentration between cigarette smoking or vaping, or during nicotine patch use. Nicotine incubation suppressed Tu-induced ER stress and the unfolded protein response (UPR). Study of mice with fluorescent nAChR subunits showed that the cultured TH+ neurons displayed α4, α6, and β3 nAChR subunit expression and ACh-evoked currents. Gene expression profile in cultures from TH-eGFP mice showed that the TH+ neurons also express several other genes associated with DA release. Nicotine also upregulated ACh-induced currents in DA neurons by ∼2.5-fold. Thus, nicotine, at a concentration too low to activate an appreciable fraction of plasma membrane nAChRs, induces two sequelae of pharmacological chaperoning in the ER: UPR suppression and nAChR upregulation. Therefore, one mechanism of neuroprotection by nicotine is pharmacological chaperoning, leading to UPR suppression. Measuring this pathway may help in assessing neuroprotection.
Menthol Alone Upregulates Midbrain NAChRs, Alters NAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2016 | Pubmed ID: 26961950 Upregulation of β2 subunit-containing (β2*) nicotinic acetylcholine receptors (nAChRs) is implicated in several aspects of nicotine addiction, and menthol cigarette smokers tend to upregulate β2* nAChRs more than nonmenthol cigarette smokers. We investigated the effect of long-term menthol alone on midbrain neurons containing nAChRs. In midbrain dopaminergic (DA) neurons from mice containing fluorescent nAChR subunits, menthol alone increased the number of α4 and α6 nAChR subunits, but this upregulation did not occur in midbrain GABAergic neurons. Thus, chronic menthol produces a cell-type-selective upregulation of α4* nAChRs, complementing that of chronic nicotine alone, which upregulates α4 subunit-containing (α4*) nAChRs in GABAergic but not DA neurons. In mouse brain slices and cultured midbrain neurons, menthol reduced DA neuron firing frequency and altered DA neuron excitability following nAChR activation. Furthermore, menthol exposure before nicotine abolished nicotine reward-related behavior in mice. In neuroblastoma cells transfected with fluorescent nAChR subunits, exposure to 500 nm menthol alone also increased nAChR number and favored the formation of (α4)3(β2)2 nAChRs; this contrasts with the action of nicotine itself, which favors (α4)2(β2)3 nAChRs. Menthol alone also increases the number of α6β2 receptors that exclude the β3 subunit. Thus, menthol stabilizes lower-sensitivity α4* and α6 subunit-containing nAChRs, possibly by acting as a chemical chaperone. The abolition of nicotine reward-related behavior may be mediated through menthol's ability to stabilize lower-sensitivity nAChRs and alter DA neuron excitability. We conclude that menthol is more than a tobacco flavorant: administered alone chronically, it alters midbrain DA neurons of the nicotine reward-related pathway.
Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity α4β2, and Increases α5α4β2, Nicotinic Receptor Surface Expression PloS One. 2016 | Pubmed ID: 27336596 A number of mutations in α4β2-containing (α4β2*) nicotinic acetylcholine (ACh) receptors (nAChRs) are linked to autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), including one in the β2 subunit called β2V287L. Two α4β2* subtypes with different subunit stoichiometries and ACh sensitivities co-exist in the brain, a high-sensitivity subtype with (α4)2(β2)3 subunit stoichiometry and a low-sensitivity subtype with (α4)3(β2)2 stoichiometry. The α5 nicotinic subunit also co-assembles with α4β2 to form a high-sensitivity α5α4β2 nAChR. Previous studies suggest that the β2V287L mutation suppresses low-sensitivity α4β2* nAChR expression in a knock-in mouse model and also that α5 co-expression improves the surface expression of ADNFLE mutant nAChRs in a cell line. To test these hypotheses further, we expressed mutant and wild-type (WT) nAChRs in oocytes and mammalian cell lines, and measured the effects of the β2V287L mutation on surface receptor expression and the ACh response using electrophysiology, a voltage-sensitive fluorescent dye, and superecliptic pHluorin (SEP). The β2V287L mutation reduced the EC50 values of high- and low-sensitivity α4β2 nAChRs expressed in Xenopus oocytes for ACh by a similar factor and suppressed low-sensitivity α4β2 expression. In contrast, it did not affect the EC50 of α5α4β2 nAChRs for ACh. Measurements of the ACh responses of WT and mutant nAChRs expressed in mammalian cell lines using a voltage-sensitive fluorescent dye and whole-cell patch-clamping confirm the oocyte data. They also show that, despite reducing the maximum response, β2V287L increased the α4β2 response to a sub-saturating ACh concentration (1 μM). Finally, imaging SEP-tagged α5, α4, β2, and β2V287L subunits showed that β2V287L reduced total α4β2 nAChR surface expression, increased the number of β2 subunits per α4β2 receptor, and increased surface α5α4β2 nAChR expression. Thus, the β2V287L mutation alters the subunit composition and sensitivity of α4β2 nAChRs, and increases α5α4β2 surface expression.


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Rezoning recommended
Former ThedaCare site awaits council approval
By Bert Lehman
The Clintonville Plan Commission approved rezoning the former ThedaCare office property at 32 Hughes St. from B1 – Downtown Business District to R2 – Residential District.
The purpose of the rezoning is to allow Ricky and Shelley Liebman to convert the building into a single-family residence and eventually a duplex.
At a plan commission public hearing March 20, Clintonville City Administrator Chuck Kell said the property is currently zoned B1, which does allow for duplexes if certain criteria is met.
Kell said Liebman would like to have the property rezoned.
Kell added that duplex zoning requires 10,000 square feet. The lot in question is 18,000 square feet, Kell said. A duplex property must also have a minimum width of 80 feet. The lot in question is 120 feet by 149 feet.
"It meets all the area standards for a duplex," Kell said during the public hearing.
Kell said all the surrounding property is zoned R1 – single family residence. The exception is the property across the street, which is the Aster property.
Ricky Liebman told the plan commission that he and his wife would probably convert the building to a duplex sooner rather than later.
"The whole premise of us doing this is we're downsizing," Ricky Liebman said.
They currently own a large house in the Embarrass area, which they plan on selling.
He said they would start remodeling the former ThedaCare office building as soon as the property is rezoned.
The rezoning request will have to be approved by the Clintonville City Council.


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Doors Can be Opened by a Distance Learning Bachelors Degree
Post: #1
Doors Can be Opened by a Distance Learning Bachelors Degree
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Caroline Winberg began her modelling career at age sixteen, and a year later was booking local gigs and appearing in promotional spots for regional companies. She soon caught the eye of several well-known agencies – including Women Model Management, Why Not Milan and Dominique Brussels – and found herself in campaigns for designers such as Valentino, Versace, Oscar de la Renta, Escada, and Armani. She has also been … [Read more...]
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|Good For The Skin
Kitty has a problem with her skin and visits Dr Josh for some expert help. He finds that she has a lack of Zinc in her diet and advises her to get a boyfriend and encourage him to cum on her face as cum is rich in Zinc and anti-oxidants. Kitty is so desperate to clear up her problem she persuades the Doctor to give her a dose of his hot, white sticky jizz there and then. Dr Josh obliges and squirts jet after jet of his ball juice all over her face. Kitty is a lovely and beautiful girl but very shy. This was her first ever day in Porn and to my knowledge her last. Listen to the BTS at the end and decide for yourself if she enjoyed a faceful of spunk or not. Let me know via the comment button.
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Web Browsers
For optimal performance when when accessing the platform through a web browser we support the following browsers and versions:
Google Chrome - versions 25 and above
Safari - versions 6 and newer
Mozilla Firefox - versions 5 and newer
Microsoft Internet Explorer (IE) - versions IE11 and newer
- IE10 and older versions are currently not supported at all and may not allow you to execute core functions of the platform. If you are using one of the older IE versions through a corporate environment, we recommend you download another one of the above, newer, browsers and versions that is supported.
- Older versions of Chrome might also be supported although there could be some spotty performance. Since Chrome updates automatically in the background most users are already using a newer version.


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So I am going to buy the incubator today as my hen laid another egg yesterday and I am going to need it soon. I am told seramas are fussy, hard to hatch, and hard to raise. This attracts me like a moth to the flame. I like challenges. Still, what do you breed for in seramas? I know most people breed solely for size. Most use B sized breeding pairs and some are lucky enough to have A sized breeding pairs, although birds that small are notorious for fertility problems.
I am brought back to my older breeding ethics with the other animals I have dealt with. I have never bred for breed standard for anything and that's because health and temperament were always more important to me. I know the 'extreme seramas' fetch a high price ($100-500 a bird) but they look so unnatural I have a hard time believing such an altered stance doesn't do something to their health. Many extreme dog and cat breeds are riddled with health problems and I find that disturbing and preventable. For example flat-faced breeds of both dogs and cats often have breathing problems and get respiratory infections very easy because water goes straight up their nose whenever they drink water and their tongue hits it. I have found no reports of seramas having any issues due to their stance but I still can't rule it out.
Some breeders are trying to make seramas into a show breed. They have started by only breeding the white ones together for many generations, completely obliterating any other color genetics in their background that may cause chicks to come out looking different from their parents. This seems a dreadful idea to me. Part of the seramas charm is that they do come in every color under the sun and you never can predict with 100% accuracy what you are going to get. Other breeders have crossbred seramas with frizzled and silkie bantams in order to change their feathers. These can be quite charming, probably have a wider gene pool, and they intrigue me. Still other breeders are only allowing crow-less roosters into their breeding programs. These birds pop up naturally in the breed from time to time and are probably more suited to a pet environment as they are much quieter. Bizarrely some people think its cruel to breed for this quality, stating a rooster is an animal that needs to crow, as if they've been surgically de-crowed or something. We have at least one barkless dog breed, Basenjis, that are physically incapable of barking and they do not live miserable lives. Why would they? They never knew what it was like to bark in the first place. I think crow-less roosters could be a good thing, especially for pet hobbyists…
The last thing I found people breeding for was temperament. You'd think this would be higher up on the list! I found one breeder who stated if the seramas were not naturally friendly towards people without ever being handled or socialized then they were not worth allowing into abreeding program. I sort of agree… which makes my hen a lousy candidate but I have to start somewhere and she's not mean or anything. She's actually getting used to me and doesn't mind handling so much. She's just not super affectionate.
In any event I wish to make a nice little serama coop and run next week that will be a little more chicken friendly than the 4 level cat cage they're in now. I cart it outside and back in at night but with a coop they can manage that themselves and be able to peck at the grass. I really want to ship a few more hens in and am contemplating getting into contact with the guy who first imported them. He seems like the largest breeder out there and I think will have the best possibility of selling me exactly what I want – affectionate natural looking birds with good health and a high propensity for throwing many colors. They'll all likely be smooth but if that little project works I would just love to get into the frizzled ones as well. I have added photos of other people's birds to show you what I have been talking about here.
This is a micro serama – they are even smaller than a size A and I haven't found any accounts of them ever being fertile so they're hard to obtain!
This is a Size A serama, which also have a lot of fertility issues due to their size but some of them are able to produce offspring.
This is a frizzled serama (the the left) – as you can see the feathers are curled compared to the smooth serama on the right.
And here is a silkie serama, which in adulthood will still have mostly the down feathers of a newborn chick.
Finally this is an extreme serama – when he stand his head literally flings backwards and touches his tail.


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Cutting the cake
For him...
For her...
The wedding went well-thank you to those who have been praying for our family!!
Please continue to keep Jess and Katelyn in your prayers-Jess has gallbladder disease-and had been very sick-they might try to induce her about two weeks before little Katelyn's due date.
Caleb and his new bike-he can not ride it but he loves to just sit on it and smile for Mommy.
Truck rider-he saw this picture and told me about how he rode the truck at Walmart. He gets smarter by the minute!!
Monday, January 7, 2008
More Wedding Photos-2 and Caleb photos
Posted by Happy Homemaker And Momma at Monday, January 07, 2008
1 Lovely Comments:
- Tiffany said...
HI Kelly!
It was great hearing from you. I was looking on your site and saw your counter of how long you have been married...I can't believe you have been married over 4 years!! I still remember flying out to Ohio and doing your hair for your wedding!!! That walmart is about 35 minutes from us according to mapquest. Let us know when you would be able to get together and I am sure Josiah wouldn't mind. It would have to be a Saturday, though since he doesn't get home from work until 7pm.
Thanks for emailing me! Have a great day
- Friday, February 01, 2008 12:40:00 PM
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Tennis Lessons
Tennis lessons are free.
The tennis schedule for this year is below. Students may choose either a Monday/Wednesday lesson or a Tuesday/Thursday lesson. Fridays will be games for everyone. Our goal is to limit the numbers to 6 children per court in order to get students the individual attention they need
Monday/Wednesday Tuesday/Thursday Friday
9:45-10:35 6-8 year old 11-13 years old 6-8 year old games
10:45-11:35 9-10 year old 6-8 year old 9-10 year old games
11:45-12:35 11-13 year old 9-10 year old 11-13 year old games
On Friday morning, an hour-and-a-half clinic for adults will be offered from 8:00am-9:30 am for $20 per session. The clinic will involve drills, instruction, and some games. You will get a great workout. If you are interested, please sign up at the gatehouse or let Eric know.
Tennis Team
Fees for Tennis Team are the same as Swim Team:
First child: $45
Second child: $40
Third child: $35
Fourth child: Free
Varsity team practices will be held every day from 1:15-2:15
Junior Varsity team practices will be on Mondays and Wednesdays from 11:45-12:35 and 1:15-2:15.
Varsity team is intended for players aged 12 and over who are experienced at match play.
Junior Varsity is intended for players under 12 who are able to play and are almost ready for match play.
All inter-club matches start at 1:00 pm.
2018 schedule:


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Going back to the directory services well, Banyan Systems was this week scheduled to introduce a directory-enabled management tool to help companies give internal and external end users secure applications access via the World Wide Web.
The company's new SiteMinder product is not only designed to simplify a network manager's job, but also promises to make life easier for authorised end users by giving them single sign-on access to corporate applications across multivendor networks.
The directory services pioneer will also unveil Directory Advantage Services, a program under which the company will help customers plan, build and manage directory-enabled applications that take advantage of Internet technology.
The company best known for its StreetTalk directory is hoping to cash in on growing customer interest in using directory services to anchor corporate management and security schemes. Observers say Banyan, which has been on the financial comeback trail in recent months, is counting heavily on the services side of its business to generate new revenue and help complete its turnaround.
Exclusive agreement
Banyan declined to provide details on its upcoming announcements. However, the company did acknowledge that SiteMinder is based on technology from Netegrity in Massachussetts, with which Banyan recently signed an exclusive licensing agreement.
According to internal company documents, SiteMinder consists of policy server software that sits on a Windows NT or Unix box and provides ties to any Lightweight Directory Access Protocol (LDAP)-enabled directory service. Such services include StreetTalk, Novell Directory Services (NDS) and Microsoft's upcoming Active Directory Service.
The product will also ship with agents that reside on Web servers from Microsoft and Netscape, and the agents can communicate with the policy server software.
In addition, Banyan will ship an API tool kit that companies can use to build customised agents for connecting SiteMinder to their corporate applications.
One industry analyst says the usefulness of Banyan's SiteMinder could wear off quickly.
The product may provide a way for early extranet sites to establish a type of tiered access to corporate applications, says Jon Oltsik, a US-based analyst with Forrester Research. But the product could become redundant when corporate-wide directory services, such as NDS and Active Directory, begin to pick up similar capabilities.


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One-On-One Consulting (monthly)
One-On-One Consulting (monthly)
1x call per week (we will establish a regular call time each week - video calls optional)
bi-weekly homework and follow-ups ('homework' will be how we delve deeper into your specific set of business issues/problems and we will utilize this to move our work, creating solutions and options for problem solving)
We will establish the issues or problems you want to explore and/or solve through working together. Example topics such as developing your leadership and decision making, reflecting core values in business choices, team building and hiring, creating greater accountability as well as financial goals/objectives. I help you to develop possible strategies around the topic(s) we focus on and create clear, executable steps to create solutions.