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What are opiates?
One of the most addictive drugs, opiates are actually used to treat pain. They are also used to suppress coughs in severe lung conditions. They are derived from the opium poppy and include:
- Opium
- Morphine
- Codeine
- Fentanyl
- Hydromorphone
Are opiates and opioids the same? What is an opioid?
No they are not the same. While opiates are alkaloids derived naturally from opium poppy, opioids are synthetic drugs manufactured to work the same way as opiates. The two have similar molecules but the active ingredients of opioids are synthetically processed chemicals.
Types of opioids:
- Heroin
- Oxycodone
- Methadone
- Tramadol
- Fentanyl
- Hydromorphone
Are opiates and heroin the same?
No. Because heroin is synthetically processed, it is not an opiate but an opioid.
Lately, however, the terms opioids and opiates are used interchangeably. This is because they both have the same molecules, they both relieve pain and they both work in similar ways.
Opiates are very effective painkillers. So effective are they that the first known use of opiates was in 3400 BC when ancient Sumerians grew and harvested opium. Today, opiates are used medically to relieve pain during dental operations and during invasive surgical procedures.
Unfortunately, for all their medical benefits, opiates have a dark story. One that has destroyed thousands of lives, broken an equal number of families and even caused death; a story of addiction.
Opiate addiction in the United States
Opiates are one of the most abused drugs in the country because they are easy to get hold of, are very addictive and are relatively cheap.
According to the Center for Disease Control (CDC), the number of prescription opioids sold in the United States grew by 400 percent despite there being no changes in the amount of pain Americans reported.
In 2014, as many as 2 million Americans either abused or were dependent on prescription opioids.
In 2012, 259 million prescription opioids were prescribed in the country, enough to give every American a bottle of pills.
From 1999 to 2015, the number of drug overdose deaths linked to opioids quadrupled. In fact, out of the over 500,000 Americans who died from a drug overdose in that period, over 60 percent of the deaths involved opioids including prescription medications and heroin.
In 2015, over 15,000 Americans died from an opioid overdose, the most popular being narcotic pain meds methadone, hydrocodone and oxycodone.
More than 1,000 Americans are treated in emergency wards every day for overdosing on opioids.
Why are opiates so addictive? The path to opiate addiction
Aside from their pain relieving properties, opiates cause an intense euphoric "high." The feelings of euphoria are usually accompanied by sedation or drowsiness. Because many opiates have a short duration of action, they are able to cause a "feel good" high in a relatively short amount of time.
This is how opiates affect the brain to cause euphoria:
Once opiates are consumed, they release chemicals that bind onto opioid receptors in the brain's nerve cells, causing euphoria. The brain interprets euphoria positively and releases the feel good neurotransmitter dopamine as a reward for indulging. The two are responsible for the intense high. The more an addict indulges, the more the euphoria, the more dopamine is released and the more intense the high is.
Unfortunately, the more opiates an addict consumes over time, the more resistant the body becomes to its effects. Gradually, the brain develops more active opioid receptors. Therefore, to achieve euphoria, an addict has to consume more opiates. This is called drug tolerance.
To make matters worse, as addiction becomes more intense, the brain gets accustomed to flooding the body with dopamine. Over time, it begins to interpret unbound opioids as discomfort or pain, perpetuating a strong craving for the drug.
It gets to a point where dopamine is only released once high doses of opiates are ingested. This significantly affects the mood and motivation of an addict. At this point, he/she is fully dependent on the drug.
What are the negative effects of opioid addiction?
Opioid addiction has both long term and short term effects. Short term opiate effects include:
- Vomiting
- Diarrhea
- Sedation
- Slow reaction times
- Confusion
- Slow breathing
- Heightened sensitivity to pain
- Constricted "pinpoint" pupils
- Loss of consciousness
Because opiates cause delayed reaction times, many states have imposed strict laws against drivers who take to the road after using the drugs.
The long term effects of opiate addiction include:
- Weakened immune systems
- Gastric problems such as constipation or bowel perforation
- Severe respiratory depression
In cases of severe addiction, opioids do cause death. In fact, the CDC estimates that every day, 91 people die from opioid overdose . The New York Times estimates that more people die from opioid related complications than from any other drug.
How long a person stays before becoming an addict of opioids is relative. However, once dependence is established, stopping becomes very difficult. In fact, the person can suffer severe withdrawal symptoms if he/she stays long without consuming the drug.
What are the withdrawal symptoms of opioids?
They include:
- Agitation
- Muscle aches
- Sweating
- Insomnia
- Runny nose
- Vomiting
- Diarrhea
- Abdominal cramping
- Nausea
These symptoms may start anywhere from 12 to 30 hours since the addict last ingested the drugs.
Are you an opioid/opiate addict?
There are many telltale signs of prescription drug abuse. Here's a simple way to find out:
- Do you often find yourself craving opioids?
- When you get hold of the medication, do you use more than was medically prescribed?
- Are you taking higher doses to get the same "high" you'd get with smaller doses before?
- When you go a while without consuming heroin or other opioids, do you suffer withdrawal symptoms such as sweating, anxiety, muscle aches and agitation?
- Have you tried to quit but found yourself relapsing again and again?
- Have you neglected your responsibilities at school, home or work because of opioids?
- Are you burning through your financial savings or cash at hand to feed your opiate cravings?
- Have you committed illegal acts to get money to buy the substance?
- Have you gotten into legal trouble because of opioids?
If the answer is yes for a number of these questions, then it is likely you are addicted to a form of opioids.
What are the treatment options for opiate addiction?
The first step to recovery is admitting you have a heroin addiction and then seeking professional treatment. Opiate addiction treatment usually involves therapy, medication and counseling in a prescription drug rehabilitation center.
Many rehabs offer both inpatient and outpatient treatment programs. Inpatient programs have more recovery rates and typically last between 30-90 days.
At the rehabilitation center, medical professionals will usually start by conducting blood and urine tests to confirm the opioid addiction. They may also perform chest X-rays, blood analysis, liver examinations and cardiovascular tests to ascertain whether the opioid addiction has dealt a significant blow to vital body organs. These vitals will be monitored during the course of treatment.
After testing, treatment will usually begin with a drug detoxification program. A professionally conducted detox will rid the body of harmful traces of the addictive narcotic pain medication.
After detox, the addict will attend in-patient group and individual addiction recovery therapy. These will be moderated by a trained counselor. They will also attend 12-step meetings and engage in group activities such as yoga and meditation.
Because prolonged withdrawal has negative effects, patients in the recovery programs are prescribed FDA-approved medications to treat opiate addiction. These drugs include methadone, buprenorphine, clonidine and naltrexone.
Regardless of how bad or severe an addiction is, treatment is possible. With opioids, the earlier an addict commits to treatment, the better.
Opioid overdoses kill more Americans than any other drug. Do not let your loved one be a statistic.
Do you know anyone who has an opioid/opiate addiction? Ask them to take the test above to find out.


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By Jeff Fasano
Emptiness alone cannot be filled by gesture. It must be integrated within, for it simply is a space to be fulfilled
by spirit.
Physical beingness is shifting shape and form. By retracing steps to release what no longer
serves, a space is formed, a void. It is a memory of what was yet no longer can
be in divine spirit. As divine spirit evolves it abounds with joy and
fulfillment of self. It is replaced with integrated behaviors that serve the
many with love.
The peaceful warrior takes his place amongst the souls who
yearn for his reach and extends their arms to meet his. It is in this moment of
connection that joy transpires and the spark ignited to regain its form, the
form of love.
By itself one cannot exist, and the warrior sometimes laments
this. It is he who seeks fulfillment yet knows it comes with everlasting truth.
One abounds with love when one surfaces from hate. Hate of
self in purgatory of the mind. The mind deludes the truth, the everlasting
truth of love beyond thoughts and action.
The call to right action is the warrior's call. And he
accepts that call with open arms and exudes the love called forth when called
You are the Warrior of Love. Be soft, be gentle, be open, be
smart. The heart of the divine is upon you now and forever.
Forever the warrior walks amongst those who seek his
presence. They might not know his presence but when anointed with his heart,
they will then know his true presence is that of love in its purest form. This
is the energetic connection of spirit within. The energetic connection of love
that the warrior knows and always knows.
In this knowing sometimes comes doubt. Energize this with
love for the doubt is simply the unknowingness of time and space. It is with
love and acceptance that transforms doubt into reality. This the warrior knows. For it is this
knowingness that pervades in the warrior's heart that adjusts the right and
perfect path, the path to love.
And so it is… Love

subset: commoncrawl


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German hard rock veterans SCORPIONS performed in Paris, France on November 24, marking the first time the band has played the city since an extremist group orchestrated a terror attack on Paris that left 130 dead.
The sold-out concert at the Bercy arena included an emotional moment when SCORPIONS drummer James Kottak beat the rhythm of the French national anthem, "La Marseillaise", which the crowd sang a capella.
Speaking to Christian Platz of Agentinnen.net, SCORPIONS guitarist Rudolf Schenker stated about the band's decision to carry on their French tour (see video below): "I mean, for us, we called the promoter, the French promoter, and asked him what he thinks. And he said the people will go to the concert. Maybe five percent [will decide against] coming [to the gig] because [of continued terror threats] and stuff like this, but it would be very important if we go back to a normal life. And also, for us, it was important to please our fans. Because, we said, 'Okay, after this tragedy, we have to stick together and music is a bridge which can help people to overcome this tragedy.' It was like that — people were singing together. And it was not an easy decision, but, for us, it was important, especially [since] we have a very strong connection to France and [we wanted] to please [the fans] and be there. It was an amazing concert, and also Strasbourg and Lille, all the French concerts were fantastic. The people are looking for a new future and they wanna really go over it. And I think music is the best bridge to help people, and that's what we felt when we played there."
SCORPIONS singer Klaus Meine told DPA ahead of the concert: "Our France tour is overshadowed by these sad and terrible events. Of course we're also here to deal with the situation… this tragedy, respectfully."
He added: "We all feel threatened, we all feel attacked. This has hurt all of us."
However, he explained that people shouldn't live their lives on the knife's edge, somehow persuaded that a terrorist's bomb or bullet has their name on it.
"It's a rock show," he said. "We simply want to have a wicked night with our fans and make a statement in favor of life."
The new fully authorized SCORPIONS documentary "Forever And A Day" wrapped up its theatrical run and will come to DVD, Blu-ray, and digital platforms on November 27 (in German with English subtitles). The movie takes a look at the German hard-rock legends' long career, while focusing on the band's "Final Sting" trek, which initially was intended to be a farewell tour.
SCORPIONS recently completed the 2015 U.S. leg of their 50th-anniversary tour, which also is in support of their latest studio album, "Return To Forever".
Performance footage:
Source: Blabbermouth


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A tire blowout happens when you least expect it. It can also lead to a serious car accident, injuries and a trip to the auto repair shop. According to the Texas Department of Transportation, defective or slick tires caused 68 traffic fatalities in 2015. Maintaining and replacing tires is an expense, but not maintaining them and having a blowout can cost someone's life.
There are a few steps every car owner should do frequently to maintain the quality and life of the tires, and in the process, prevent serious collisions on the road.
Check Tire Tread
The amount of tire tread shows the life remaining on each tire. If your tires begin to look smooth and less rugged, it is time to replace the tire.
A good trick to use to measure tire tread is to insert a quarter into the tread with George Washington's head facing down. If you can see the top of his head, you need new tires.
Maintain Proper Air Pressure
Most newer model vehicles within the past decade feature tire pressure monitors that alert the driver if tire pressure is low. Do not rely only on the monitors. Checking tire pressure on all four tires once a month is a good habit.
If a tire is under-inflated, it can lead to tire damage. An over-inflated tire can cause a blowout, especially on long trips or in hot temperatures. Check your car owner's manual or the inside of the door frame for the correct amount of tire pressure. Also remember to have your tires rotated according to the manufacturer's specifications.
Poor Alignment and Balance Wears Tires
The air and wear are just two factors that affect tire quality and can prevent a blowout if maintained. On any vehicle, proper alignment and balance can prevent the tire from wearing faster.
At ProCare Collision, a local body shop, we hope all car owners take care of their vehicles to prevent serious accidents. If you do happen to get into an accident, contact our team to work with a personal service consultant who will help you through the entire repair process and get you back on the road.


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' Mr. Verma takes the reader back to the roots of the Indian culture, to the ideals and aspirations that energize it I highly recommend in his or her own societal context or in learning more about the moral values that lie at the heart of the Indian culture.'
RUTH H. AXELROD, GEORGE Washington University, USA.
'The Avatar Way of Leadership is a stroke of genius The book is a joy to read and to recommend.'
Dr. KLAUS K. KLOSTERMAIER, Fellow of the Royal Society of Canada
' the most valuable achievement of this book is to vindicate the oft overlooked qualities and values that the great, and successful, leaders of our epics seem to share - humility, strength of conviction, steadfast pursuit of moral goals, concern for the greater good of society, and occasional flexibility tempered by steely firmness.'
DR. ASHIS GUPTA, HASKAYNE SCHOOL OF BUSINESS, The University of Calgary, Canada
From the Back of the Book:
The Avatar Way of Leadership builds an Indian model of leadership by using insights on Jungian psychology, tales of the Avatars of Hindu Mythology and real examples of contemporary Indian leaders. It offers a unique perspective of leadership as a process comprising three successive stages: developing character, building relationships, and devising good strategies. Character attracts people. Relationships turn attraction into loyalty. Good strategies lead to victory and help sustain attraction and loyalty.
Three Avatars have been chosen for this model: Rama, Krishna and Draupadi, representing different leadership archetypes. Each archetype of leadership is explained with references to Indian leaders like president A.P.J. Abdul Kalam, Ratan Tata, Dhirubhai Ambani, Narayan Murthy, Azim Premji, among others, who have shown the same kind of leadership pattern in their life. Find out who represents which Avatar and you will know how to be the same kind of leader yourself.
Harsh Verma has lectured on Indian philosophy and leadership at international conferences and universities across the US. He is currently a consultant with Indian institute of Forest Management, Bhopal. Read his blog http://indianheroes.blogspot.com and email him at email@example.com.
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The community that the Union and Confederate soldiers approached on December 28, 1862, was a small but prosperous city.
Centered around a primary street that led from the hills beyond down to the banks of the Arkansas River, Van Buren was a center of commerical and political activity during the years leading up to the war.
The town's militia took part in the seizure of Fort Smith in 1861 and large numbers of the community's men and boys and marched off to fight for the Confederacy. Despite the fact that heavy fighting had taken place across the mountains at Pea Ridge, Cane Hill and Prairie Grove in Northwest Arkansas, most of the residents of Van Buren considered their community safe from attack in late December of 1862. Winter had settled across the region and it was not expected that combat would resume before the spring.
In fact, only a token force was maintained in and around the town by Confederate Gen. Thomas C. Hindman. Most of his army had crossed back over the Arkansas River and was camped in the area surrounding Fort Smith.
As the day warmed on the morning of December 28, 1862, the people of Van Buren were going about their business, shopping and gathering along the main street and at the old courthouse. The fighting would come upon them so quickly that most would not have a chance to flee.
Our series on the Battle of Van Buren, Arkansas, will continue. Until the next post, you can read more by visiting www.exploresouthernhistory.com/vanburenbattle1.


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Lindsay Lohan Gets MTV Reality Show Called 'Lohan Beach Club'
Lindsay Lohan Watch Me Do My Biz Thang in Greece!!!
Lindsay Lohan is snapping back to reality ... as in a new reality show, cause she's doing one for MTV.
The "Mean Girls" star will show what it's like to run her club biz when MTV launches "Lohan Beach Club" in 2019. The show will center around Lohan Beach House in Mykonos. It's the same hot spot where LiLo partied with Tiffany Trump over the weekend to raise money for victims of the massive Greek wildfires.
MTV cameras will follow Lindsay as her team of handpicked brand ambassadors prove their expertise and ambition over the course of the season ... all set at LiLo's day and nightclub on the Greek isles.
This ain't the first time Lindsay's dipped her toe into reality TV. Remember, her family did "Living Lohan" for a short-lived season in 2008 -- and "Lindsay" had an 8-episode run on OWN back in 2014.


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Health Canada approves an extended indication for KISQALI® (ribociclib) in combination treatment
- Breast cancer is the most common female cancer in Canada.1
- Advanced breast cancer is the leading cause of cancer death in women 20-59 years old.2,3
- While overall 5-year survival rates for female breast cancer are relatively high, at 87%, women with advanced breast cancer face a 22.0% survival rate over 5 years.4
DORVAL, QC, April 16, 2020 /CNW Telbec/ - Novartis Pharmaceuticals Canada Inc. (Novartis) is pleased to announce that KISQALI® (ribociclib) is now indicated when used in combination for the treatment of women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer regardless of their menopause status and in combination with various approved hormonal treatment options.
Health Canada has approved an extended indication for KISQALI®: in combination with fulvestrant for the treatment of postmenopausal women with HR-positive, HER2-negative advanced or metastatic breast cancer, as initial endocrine-based therapy or following disease progression on endocrine therapy, as well as in combination with an aromatase inhibitor (and luteinizing hormone releasing hormone [LHRH] agonist) for the treatment of pre/perimenopausal women with HR-positive, HER2-negative advanced or metastatic breast cancer as initial endocrine-based therapy.5 The approval is based on results from the pivotal MONALEESA-3 and MONALEESA-7 trials.
For women living with metastatic breast cancer, also known as Stage IV breast cancer, the cancer has spread beyond the breast to other areas of the body, such as the lungs, liver, bones or brain.6 It may happen before or after treatment, or it may develop from reoccurring breast cancer.7 Although there have been advancements in early detection and treatment, there is still no cure for metastatic breast cancer.8
"The availability of a new treatment option for more women living with metastatic breast cancer is an important milestone," said Dr. Christine Brezden-Masley, Medical Oncologist, Mount Sinai Hospital and Medical Director, Cancer Program at Sinai Health System. "This option now brings the possibility of delayed disease progression and improved quality of life to a broader patient community."
"We've learned over the years of working with young women with metastatic breast cancer that they want to live as well as they can for as long as they can. Disease stability and quality of life are extremely important. HR-positive breast cancer is the most common type in younger women, and we are thrilled that this new option is now available and will help many more women," said MJ DeCoteau, Founder and Executive Director, Rethink Breast Cancer.
KISQALI® first received Health Canada approval for use with letrozole on March 2, 2018, for the treatment of postmenopausal women with HR-positive, HER2-negative advanced or metastatic breast cancer as first-line endocrine-based therapy based on findings from the pivotal MONALEESA-2 trial.
"At Novartis, we are at the forefront of driving scientific advancements and are proud to contribute to research in metastatic breast cancer," said Daniel Hébert, Country Medical Head Oncology, Novartis Pharmaceuticals Canada Inc. "The newest indication expansion for pre-, peri-, and postmenopausal women is testament to our long-standing commitment to bringing innovative therapies that can improve the quality of life to those impacted by breast cancer."
About KISQALI® (ribociclib)
KISQALI® is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 may play a role in ensuring that cancer cells do not continue to replicate uncontrollably. KISQALI® was developed by the Novartis Institutes for BioMedical Research (NIBR) under a research collaboration with Astex Pharmaceuticals.
About Novartis in Advanced Breast Cancer
Novartis tackles breast cancer with advanced science, collaboration and a passion for transforming patient care. We've taken a bold approach to our research by including patient populations often neglected in clinical trials, identifying new pathways or mutations that may play a role in disease progression and developing therapies that not only maintain, but also improve, quality of life for patients. Our priority over the past 30 years and today is to deliver treatments proven to improve and extend lives for those diagnosed with advanced breast cancer.
About Novartis Pharmaceuticals Canada Inc.
Novartis Pharmaceuticals Canada Inc., a leader in the healthcare field, is committed to the discovery, development and marketing of innovative products to improve the well-being of all Canadians. In 2018, the company invested $52 million in research and development in Canada. Located in Dorval, Quebec, Novartis Pharmaceuticals Canada Inc. employs approximately 1,000 people in Canada and is an affiliate of Novartis AG, which provides innovative healthcare solutions that address the evolving needs of patients and societies. For further information, please consult www.novartis.ca.
KISQALI is a registered trademark.
1 | World Health Organization. Cancer Population Fact Sheet – Canada. Available at: http://gco.iarc.fr/today/data/factsheets/populations/124-canada-fact-sheets.pdf. Accessed on March 5, 2020. |
2 | Benz CC. Impact of aging on the biology of breast cancer. Crit Rev Oncol Hematol. 2008;66:65-74. |
3 | World Health Organization. Top cancer per country, estimated age-standardized mortality rates (world) in 2018, females, all ages. 2018. Available at: http://gco.iarc.fr/today/home. Accessed on March 5, 2020. |
4 | Canadian Cancer Society. Canadian Cancer Statistics, a 2018 special report on cancer incidence by stage. Available at: www.cancer.ca/Canadian-Cancer-Statistics-2018-EN. Accessed on March 5, 2020. |
5 | KISQALI®, Product Monograph, February 6, 2020. Available at: www.novartis.ca/kisqalimonograph. Accessed on March 5, 2020. |
6 | Canadian Cancer Society. What is Metastatic Cancer? Available at: http://www.cancer.ca/en/cancer-information/cancer-type/metastatic-cancer/metastatic-cancer/?region=on. Accessed on March 5, 2020. |
7 | Canadian Breast Cancer Network. What is Metastatic Breast Cancer? Available at: https://www.cbcn.ca/en/what_is_mbc. Accessed on March 5, 2020. |
8 | Canadian Breast Cancer Network and Rethink Breast Cancer. Living with Metastatic Breast Cancer in Canada. Available at: https://www.cbcn.ca/web/default/files/public/Reports/Metastatic%20Breast%20Cancer%20In%20Canada%20Report%20June%202013%20-%20English.pdf. Accessed on March 5, 2020. |
SOURCE Novartis Pharmaceuticals Canada Inc.


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Yellowknife, NWT – The MLA for the Sahtu says a federal bill has been introduced to formally establish the Nááts'ihch'oh National Park Reserve in the Northwest Territories' Sahtu Region.
Norman Yakeleya says it's an area of spiritual and cultural significance to the people of the Tulita district and an important calving ground for mountain caribou.
Yakeleya says the new national park reserve is the result of almost a decade's work.
"We had a number of barriers that the Sahtu people were up against and we had to work through all of this to make what we have today. A historical piece of our history is being preserved and is going to be operated one day by the people in the Sahtu. Hopefully people in the Northwest Territories will have the opportunity to get jobs there."
Yakeleya says the territorial government is committed to a balanced approach that creates prosperity for the N.W.T and Canada, while ensuring that the natural heritage of the territory is protected and conserved.
He says the people of the Sahtu, the G.N.W.T and the federal government have yet to decide when the park will open to northerners and the rest of the world.
CJCD Moose FM News


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Zilnic oferim programe licențiate GRATUITE pe care altfel ar trebui să le cumpărați!
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este Chilipirul Zilei!
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iPhone, iPad, iPod touch


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Xbox Boss Addresses Toxicity and Hate Speech, Says "Gaming Is for Everyone"
Microsoft's head of Xbox, Phil Spencer, shared an op-ed on Monday that addressed various topics [...]
Microsoft's head of Xbox, Phil Spencer, shared an op-ed on Monday that addressed various topics like safety in video games, hate speech, and Microsoft's plans to protect its users in an online world. Spencer laid out his thoughts about video games as a whole and the benefits that they offer to the billions who partake in the hobby while also commenting on misconceptions held by some who equate video games to violence-inducing products or timewasters.
In a blog post on Microsoft's site, Spencer called video games "a unifying force for the world." He also said that, despite what some people might have led themselves to believe, nobody "owns" gaming and asserted that the medium was open to anyone regardless of race, gender, politics, or any other factor.
"If you imagine gamers as predominantly men and specifically teen boys, think again," Spencer said. "We are a 2.6 billion-person strong community of parents playing with our kids, adventurers exploring worlds together, teachers making math wondrous, grandmothers learning about their grandchildren through play, and soldiers connecting with their folks back home. Most gamers today are adults; nearly half are women."
For everyone to take part in gaming, Spencer said "gaming must promote and protect the safety of all" and be a safe environment for players. He said the rise and embrace of gaming around the world has also happened at a time when "digital life includes a growing toxic stew of hate speech, bigotry and misogyny." To combat that toxicity, hate speech, and other issues, Spencer said the Xbox Safety team is committed to expanding so that it may identify and solve safety problems.
"We will identify potentials for abuse and misuse on our platform and will fix problems quickly," he said. "We are also intent on expanding the composition of our safety team so wide-ranging perspectives can help us identify future safety problems and solutions.
Gaming has the power to become one of the most significant unifying forces for the world. Together, the entire gaming industry can make this a reality by answering the fierce urgency to make gaming safe and inclusive of everyone. I hope you'll join me: https://t.co/O68DLj0d5X
— Phil Spencer (@XboxP3) May 20, 2019
Microsoft updated its community standards not long ago with more clarifications and guidelines, some of which showed users how to properly and respectfully trash talk. Though the Xbox Ambassador program and "new programs for the health of our entire gaming community," Microsoft will continue looking for more ways to protect gamers. It also plans on sharing safety innovations with others in the industry.
"Because we intend to protect all gamers, we will openly share safety innovations with our industry the same way Microsoft has made PhotoDNA technology universally available to everyone from the police to the tech industry to fight the spread of child pornography," Spencer said. "Today, multiple teams working in areas like moderation, user research, data science, and others are already aligning with industry partners to share insights, and best practices in areas of safety, security and privacy."
Spencer's full post about Microsoft's role in keeping gamers safe can be seen here.


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I thank god that I found this British college slut. This 19-year-old girl with little rack gets super horny and she decides to ride her massive pink dildo on her today's live cam show. When she is not busy with the college stuff, she absolutely loves to do a solo session and have a chat and fun with the crazy strangers.
I know that she is a big fan of masturbation and she masturbates even a three times a day. Holy fuck, she is a one very wild model.


text:
New forms of automation are radically transforming society. Advanced robotics and artificial intelligence are increasing productivity and improving lives. However, what will happen to our jobs and what skills will we need to perform them? In the following talk, David will provide answers to these questions and explain why we should look at technological developments with hope, rather than fear. David Timis is a EU Civics Outreach Fellow at Google and the Co-Founder of European Heroes, an initiative aimed at encouraging civic engagement among young Europeans.
Quelle: YouTube - - David Timis | TEDxLuxembourgCity


text:
I'm just going to say it, I would like to completely blow up employment classification as we know it. I do not think that defining full-time work as the place where you get benefits, and part-time work as the place where you have to fight to get a full-time job, is an appropriate way of addressing this labor market.
Google just has to grow. It has to keep growing. But Google grows at its own peril. Google grew so much that what happened? It outgrew Google. Google had to become what? Alphabet. Now what is Alphabet? Alphabet is not Google. Alphabet is a holding company. So Google's new business as Alphabet is to do what? It's to buy and sell technology companies. So, once a company becomes just too big to flip anymore, it becomes a flipper of other companies.
We are a communal animal that's developed to believe that it's the center of the universe. And we behave as such. You know, we want to conquer, because our brain is wired to want to eat and fuck another day, you know what I mean. That's what we're wired to do. That's where our evil comes from. It's our animal roots that cause us to need things, and desire things.


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Home |
Apparition of Our Lady of La Salette
Excerpt from book:
Account of the EventLate on the evening of Saturday, the 19th of September, 1846, two children, servants of two of these farmers, returned from the mountain where they had been engaged all day in keeping cows, and told their masters a very wonderful story. The eldest of the children was a girl of fifteen years of age, who had been out at service ever since she was nine or ten years old, and had been with her present master for the last six months. We have seen and conversed with this girl, and shall have occasion to speak more particularly of her by and by. The other child was a boy of eleven, who was quite a stranger in the village, having been brought from the town of Corps, a distance of three or four miles, only on the previous Monday, as a temporary substitute for a cowherd that was ill. These two children, then, told the following tale: — They said that about midday they had driven their cows, according to their usual practice, to a certain rivulet to drink; that they had at the same time consumed the store of provisions which had been given them when they left home in the morning, and that after wandering about a little, they lay down on the grass and fell asleep near a fountain which was at that time dry; that the girl, Francoise Melanie Mathieu, was the first to awake, and seeing that the cows had strayed, she immediately awoke her companion, Pierre Maximin Giraud; that they went together to look for their cattle, and from the brow of the hill almost immediately discovered where they were ; but before going to reclaim them and drive them to their proper pastures, they turned back to the place where they had slept to fetch their empty provision bags; that their eyes were at once arrested by the appearance of a very extraordinary brilliance, dazzling as the sun, yet not of the same colour; and that this was presently succeeded by the more distinct vision of a lady radiant with light, sitting on the stones at the head of this dry fountain, in an attitude of the most profound grief. She was clothed in a white robe studded with pearls, and a gold-coloured apron; white shoes, and roses of every variety of colour about her feet; a wreath of roses around her head-dress, which was high and a little bent in front; upon her breast was a crucifix, suspended by a small chain from her neck ; on the left of the crucifix was a hammer, and on the right the pincers; another and larger chain encircled all these instruments of the Passion, and this again was within a still larger wreath of roses. When she stood upright, she was of a tall and majestic appearance, — so tall, Melanie assured us, that she had never seen any one of equal height; the children, however, were unable to gaze steadfastly upon her countenance because of its brightness. At present her elbows rested on her knees, and her face was buried in her hands, whilst tears flowed copiously from her eyes. The girl was frightened, and dropped her stick; but the boy bade her pick it up again, adding that he should take care of his, for that if it (meaning the figure which they saw) offered to do them any harm, he would give it a good blow. The lady then rose, crossed her arms, and in a gentle voice bade the children not be afraid, but to come forward, for that she had great news to tell them. The children obeyed the summons, and the lady advanced to meet them. Presently she stood between them, and addressed the following words to them, weeping as she spoke: "If my people will not submit themselves, I must let the hand of my Son fall upon them; it is so strong, so heavy, that I can keep it up no longer. How long a time have I suffered for you! If I wish my Son not to abandon you, I am obliged to pray to Him without ceasing; and yet you pay no regard to all this. However much you may pray, whatever you may do, yet you never can recompense all the trouble that I have taken in your behalf. I have given you six days to labour in, I have reserved the seventh for myself; yet they will not give it me. - It is this which makes the hand of my Son so heavy. Wagoners cannot swear without introducing the name of my Son. These two things are what make the hand of my Son so heavy. If the harvest is spoilt, you yourselves are the only cause of it. I made you feel this last year in the potatoes, but you took no account of it; on the contrary, when you found the potatoes were spoiled, you swore, and you took the name of my Son in vain. They will go on as they have begun, and by Christmas there will be none left." Thus far the lady had spoken in French, and the girl had not understood what she was speaking of in this last sentence, because in the patois of that country potatoes are not called pommes de terre, but truffes. Melanie, therefore, was going to ask Maximin what was the meaning of this word, pommes de terre; but she had not yet spoken, and the lady knowing her thoughts, anticipated her words by saying, "Ah, my children, you do not understand me, I will speak differently;" and she then went on to repeat the very same sentence — beginning with the words, "If the harvest is spoilt,—" using the patois of the neighbourhood. This she also continued to use in the following: "If you have corn, you must not sow it; all that you sow the beasts will eat; any that comes up will fall to powder when you thresh it. There will come a great famine; and before the famine the children under the age of seven years will be seized with a trembling, and will fall in the hands of those that hold them; the rest will do penance by the famine. The nuts will become bad, the grapes will rot; but if they be converted, the stones and the rocks will change into heaps of corn, and the potatoes shall be self-sown in the earth." Here the lady paused, and it seemed to Melanie that she was speaking to the boy, but she heard nothing of what was said; then, in like manner, she spoke to Melanie, and the boy saw that she was speaking, or seeming to speak, but could not hear what was said, or whether any thing was really being said at all. Only afterwards, when the vision had disappeared, the children spoke to one another about this mysterious silence, and each declared to the other that the lady had at this juncture confided to them a secret, which they were on no account to reveal to any one until the time came for so doing. Neither knew any thing about the secret of the other, whether it was the same as his own or different. The lady then resumed her discourse to the two children together, asking, in the patois of the country, "Do you say your prayers well, my children?" "Not very well, ma'am." The lady replied, "Take care always to say your prayers, my children, every night and morning. When you can do nothing else, say only a Pater and an Ave Maria; but when you have time, say more. Only a few old women go to Mass, the others work on Sundays during the summer; and in the winter, when they know not what to do, the youths go to Mass only to make a mockery of religion. In Lent they go to the shambles (butcher shops) like dogs. Did you ever see corn that was spoiled, my child?" Maximin answered, "No, ma'am." Melanie too gave the same answer, but in a gentle tone, for she was not sure whether or not the question had been addressed to her as well as to her companion. The lady then spoke to Maximin, and said, "You have seen it, my child, once when you were with your father at Coire. The owner of a piece of ground there told your father to go and see his wheat that was spoilt. You went, both of you, and you took two or three ears of corn in your hands; you rubbed them, and they crumbled into dust. Then you went home; and whilst you were about half an hour's walk from Corps, your father gave you a piece of bread, and said, 'Take this, my child, let us eat it this year whilst we can get it; I don't know who will be able to eat any next year, if the wheat goes on like that.'" Maximin answered, " Oh, yes, ma'am, I remember now; just now I had forgotten all about it." Then the lady spoke once more in French, and said, "Well, my children, you will cause this to be told to all my people;" and with these words, she passed on before the children and crossed the rivulet, and ascended the short but steep side of the opposite slope; then she turned back again and repeated the very same words; and again she walked forward to the spot where the children had gone when they were in quest of the cattle. She did not touch the ground as she walked, but moved along on the tops of the grass; the boy and girl followed in her track. Then the girl moved forward a little in advance, and the boy walked on one side of the lady; and presently the lady seemed to rise in the air about three or four feet from the ground, after which the children lost sight of her head, then of her arms and body, and lastly of her feet, and there was nothing left but a great brilliance; by and by even this too was gone... And Melanie and Maximin began to speculate as to who this stranger could have been. Hearing her speak of the weight of her Son's arm, they had at first imagined that it was some woman who had been ill-treated by her son; but now Melanie said that she thought it must be some great saint, and Maximin said, that if he had known this, he would have asked her to take them along with her; and both wished that they could bring her back again. Maximin stretched out his hand to catch some of the bright light and of the roses which had seemed to surround her feet, but he found he had grasped nothing. Still they gazed and gazed, hoping they might see something more, but nothing returned; whereupon they came to the conclusion that the lady had made herself invisible on purpose that they might not see whither she went. So they gave up the search and went to look after their cows. There were other boys and girls on different parts of the mountain engaged in the same occupation as themselves; but the children had not exactly understood who 'mon peuple' were of whom the lady had spoken, and to whom she had desired them to communicate what she had said; so they thought it their duty to hold their tongues, and they told nobody what they had seen until they got down into the village, when they immediately told it to their respective masters. They came first to the house of Melanie's master, and both went in together and told it to him; then the boy alone went on to the farm to which he belonged, and as soon as his master came home, he communicated to him the same story. ... We must not omit to mention another circumstance also which tended greatly to give credibility to the children's words, viz. that an intermittent fountain at the spot where this "lady" first appeared, and which on that day and for some time previously had undoubtedly been dry, was found to be flowing copiously on the following morning, and had never since ceased; nor has it ceased up to the present day, though previously to the apparition it flowed only at rare intervals, after a heavy fall of rain or the melting of snow upon the mountains.
James Spencer Northcote,
A Pilgrimage to La Salette, ... See also


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ETJ Kagoshima:
What is Red?
Date: Sunday, March 28th, 2010 Time: 2:00 PM - 4:30 PM
Speaker: David Lisgo
David Lisgo will explore the areas of pre-reading and initial reading skills through the use of simple materials, songs, games and activities for their practical use in the classroom. Participants will have the opportunity to share their own ideas and experiences, should they wish to do so.
Organization: ETJ Kagoshima (English Teachers in Japan) (ETJ Kagoshima)
Cost: ETJ Members: 500 yen
Non-members: 1000 yen
Venue: International Exchange Conference Room, 1st floor Kagoshima Kenmin Kohryu Center, Yamashita-cho, Kagoshima-shi
Location: Kagoshima City, Kagoshima Prefecture, Japan
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2019 has been a bit of a rollercoaster ride for those in the crypto sphere, and one thing that is on the mind of many is the upcoming Ethereum fork in January. As everyone knows, a hard fork is one of the most crucial events in the lifetime of any cryptocurrency, and when it happens to be the world's second-biggest cryptocurrency, then there is going to be a lot of anticipation.
Key Details
The reason behind choosing to do a hard fork on January 1 is a bit ignominious for the people behind the network.
The whole thing has its basis in the Istanbul fork, which took place a few weeks earlier. At the time, the team of developers who had been responsible for the whole operation had forgotten to close the difficulty creep. The hard fork is being done on January 1 since it is a well-known fact that New Year's Day is a relatively quiet period when it comes to crypto trading activities. That being said, it should be noted that this is still a significant event for all those who are invested in Ethereum.
However, the developers will need to update a whole node in order to complete the fork, and that might require them to stay up all night. Such a job may not be everyone's cup of tea on New Year's Day, and hence, it remains to be seen if the network can complete the whole operation without any glitches.
>> Libra Has 'Failed' in Its Current Form Says Swiss Finance Minister
If there is even the smallest of errors, then the hard fork will go into a tailspin, and it would be very difficult for Ethereum to recover. It is quite clear that people who are invested in the crypto token are going to watch the event closely.
Featured image: DepositPhotos © sadsadang


text:
Stacchezzini, Riccardo, Melloni, Gaia and Lai, Alessandro (2016) Sustainability management and reporting: the role of integrated reporting for communicating corporate sustainability management. Journal of Cleaner Production, 136 (Part A). pp. 102-110. ISSN 0959-6526
Full text not available from this repository.Abstract
According to the International Integrated Reporting Council (IIRC), integrated reporting (IR) should disclose the leading indicators that managers use in their sustainability decision processes and thus overcome traditional silo thinking. In this respect, IR could favor the integrative management of sustainability. Yet some scholars are more critical and argue that IR cannot contribute to sustainability management. This article contributes to the debate by analyzing how IR adopters communicate managerial aspects of corporate sustainability. Drawing on impression management studies, this study seeks to detect manipulations in this disclosure practice. A manual content analysis of reports available on the IIRC website and a multivariate statistical analysis reveal that firms offer biased IR disclosures. Firms not only provide limited forward-looking and quantitative disclosure of their actions to achieve sustainability outcomes but also avoid providing information about their sustainability performance when their social and environmental results are poor. The evidence suggests pessimistic conclusions about the capability of this reporting process to encourage the integrative management of corporate sustainability.
Item Type: | Article |
Uncontrolled Keywords: | integrated reporting,sustainability management,sustainability reporting,sustainability accounting,leading indicators,impression management,sdg 12 - responsible consumption and production ,/dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production |
Faculty \ School: | Faculty of Social Sciences > Norwich Business School |
UEA Research Groups: | Faculty of Social Sciences > Research Groups > Accounting & Quantitative Methods |
Related URLs: | |
Depositing User: | Pure Connector |
Date Deposited: | 24 Sep 2016 00:55 |
Last Modified: | 21 Oct 2022 06:33 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/60279 |
DOI: | 10.1016/j.jclepro.2016.01.109 |
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Klerksdorp - The emergency services in the North West has received an extra boost with the graduation of 24 students from the emergency care technician training programme from the North West Emergency Medical Rescue Services (EMRS) College.
These emergency care technicians will help ensure that appropriate and efficient quality care is given to patients, particularly in rural areas. The graduates are qualified to make decisions as practitioners, but with limited independent practice.
The graduates will also form part of the team which will be working during this year FIFA Confederations Cup and the 2010 FIFA World Cup.
Speaking at the graduation ceremony held in Orkney at Klerksdorp, the Deputy Minister of Health, Dr Molefi Sefularo said: "The2009 FIFA Confederations Cup in June this year and the 2010 FIFA World Cup will also benefit from the in-depth knowledge and skills of these new emergency care technicians.
"They will add to those health professionals who will be able to respond effectively to emergency medical care and disaster situations during the main two soccer event."
One of the graduates, Daphne Josopi, told BuaNews said she would avail herself for the two main soccer events to be hosted in Rustenburg,
"I completed my two years in this programme which was challenging because we had to do a lot of practical work, but even though it was challenging, I learnt a lot of stuff that will help me do my job in a very professional manner," said the 25-year-old.
She added that she was looking forward to helping her community.
There are currently 392 learners in the programme at the North West EMRS College.
They are funded by the provincial Department of Health through a bursary contract. The two-year National Certificate Programme is National Qualifications Framework (NQF) level 5, registered with the South African Qualifications Authority.
The introduction of the programme by the department forms part of an initiative to introduce a new mid-level worker qualification for an emergency care technician and addresses the pressing human resources challenges facing health delivery in the country.
There are other EMRS colleges in Orkney in the North West, Lebone in Gauteng, another in KwaZulu-Natal as well as the South African Military Health Services.


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Engineering firm Pryme Group has confirmed it has started a redundancy process at its base in Newcastle following "continued losses".
The Dundee-headquartered manufacturer said it had taken the decision to relocate some of its machining capability to other parts of the UK.
Pryme did not say how many people would be made redundant, but eight of the 18 machines at the Newcastle site will be relocated to Morecambe and Dundee.
The firm said the redundancies only affect the Newcastle site at Tyne Tunnel Estate, North Tyneside but did not elaborate on how long the process is expected to take.
There are thought to be around 50 workers at the facility.
It comes as the company posted a £7.8million pre-tax loss for 2019, which it blamed on the effect of the "protracted oil and gas downturn" on trading conditions.
Chief executive Angus Gray said: "As part of the restructuring plan for our business in Newcastle following continued losses, we have taken the decision to relocate some of the group's machining capability to other locations in the UK.
"After careful consideration, it was determined that the needs of our clients in the Newcastle area could be best met by focusing on our heavy machining capabilities.
"There are currently 18 machines able to handle 300mm to 2000mm in diameter at our Newcastle operation, located in the Tyne Tunnel Estate, North Tyneside. Eight small-to-medium-sized ones will be relocated to Morecambe and Dundee to further enhance profitability in these business units.
"Unfortunately, as a result, we have begun a redundancy process in Pryme Group Newcastle. All those impacted have been communicated to and the company will be in a position to provide a further update once this process has been finalised."
Last year the group announced it would be expanding its footprint with the creation of a new engineering services division on Tyneside, with a new 58,000ft2 workshop in North Shields, built at a cost of £9.5m.
At the time Mr Gray described it as a strategy of "continuous investments" to "capitalise on opportunities as the recovery in oil and gas gains traction".
Pryme Group also owns Dundee-based GA Engineering Scotland and Ellon-based SengS.


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I've kept a journal off and on since I was a junior in high school, which is quite a feat for a guy like me. They're all stacked in an old steamer trunk I keep in the corner of my office, a hodgepodge of spiral notebooks, leather journals, and batches of loose leaf notebook paper bundled with crumbling rubber bands.
I seldom dig through them. Any thoughts of those scribblings being anything that resembles writing fodder would be cast aside by the briefest of glances. In those books are pathetic attempts at poetry and even worse tries at art. There are song lyrics by everyone from Jimmy Buffett to Axl Rose, love letters to forgotten sweethearts, and at least one ticket from many high school dances.
But though I never care to venture in there, I can't seem to throw any of it away. That seems a little strange when I think about it, since the majority of those pages represent periods in my life that I tried for years to forget or—at the very least—put behind me. Years that I wandered through my days with neither faith nor hope, not living but merely existing.
When I sit here at my table during those small hours of the night, I often glance up from my computer screen to take fleeting look at that trunk. I try to tell myself I do this to make sure the trunk is still there, but that's not the reason. Not really.
The real reason? Well, the real reason is that I need all of those journals. No matter how painful some of those memories may be, I need to remember where I've been before if I'm to be reminded of where I am now. Even if it means carrying my share of regrets.
It wasn't supposed to be like this. That's what I once told myself. I was supposed to be the man who lived his life with the sort of balls to the wall, take no prisoners sort of mentality that guaranteed a regret-free existence. Didn't turn out that way. I can look back on my life and find more that I did wrong than I did right.
Erasing my regrets can't be done, of course. They are like pencil marks that have been rubbed out. Some are light and barely seen, and some are so deep that their impressions remain. Either way, the end result is the same—the blank sheet of my life, the one that was to be filled with beauty and perfection, is now smudged. I can cover those smudges up. I can cover them with lines and words and pictures so that they're invisible to most who bother to look. But I can still see them, and in the end I suppose that's all that matters.
The other cheek we're told we should turn to others is very often the one we refuse to turn to ourselves, just as the burdens we place on ourselves are always greater than the ones the world places on us. It is a battle, this life. One fought not on the battlefields of distant countries, but inside each of us. The world is a mess because we are a mess.
I say all of that so I can say this:
Our lives are not one long and straight line with birth at one end and death at the other. It is instead a line that curves and dips and sometimes even doubles back upon itself in not one birth or death, but many. Some parts of our lives must end so others can begin. We must say goodbye to some so that we may say hello to others.
In the end our lives are a process by which God both guides and prods in order to make us into the people he wishes us to be, people still flawed and still fallen, but with hearts ready to love and a purpose to help cast aside the shadows of this world. It is a long process. Painful at times and at times confounding. But it is a holy process, a hardening of coal into diamonds, and one we must be faithful to.
Because it's true that God loves us just the way we are, and it is also true that He loves us too much to leave us that way.
(This post is part of the One Word at a Time blog carnival on Faithfulness. To read more entries, please visit Bridget Chumbley)


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The COVID-19 coronavirus has taken the world by surprise, but adaptation is man's best quality. After an initially harsh lockdown throughout Pakistan, the system seems to be relaxing slowly. Even though practicing social distancing and other precautionary measures remain important, life must go on.
Similarly, one of the most immensely important elements of our lives, our favorite food has returned to our homes as well. Yes, you guessed it correctly. foodpanda is back and every one of us knows how much we've missed it!
The past few weeks have been so tough for us, right? From our mental health to the lack of physical activities, the times sure have been tough. But you know what makes everything better? Our favorite food items that almost instantly cheer us up.
Oh, how we've missed the burgers, the pizzas, the barbecued food, and everything else we are so used to. Yes, we do love food cooked at home, but there's something about eating from our favorite restaurants that have become so important for us.
Finally, after the federal government eased lockdown restrictions, restaurants will now operate again and foodpanda will bring us what we need. Apart from getting our favorite items, the company has made sure that sanitary precautions are taken both for riders and gear used during orders.
The immense demand for foodpanda's return was evident on social media…
Yaar mahina hogia ha.. blast hogai ha, @faisalahmadj bhai, @foodpanda_pk to khulwado!!
— Syed Zahir (@sXahir) April 16, 2020
I miss you @foodpanda_pk
— saeen. (@saeen_rafay) April 14, 2020
Missing @foodpanda_pk ??? pic.twitter.com/yDtMl5716B
— م ہ ر و ?جام شیریں ? (@Itz_Mehru) April 14, 2020
It looks like our prayers were heard by the Almighty and the government because foodpanda is back and all you have to do is order now.
Not just fulfilling our craving, foodpanda is also looking after our unsung heroes during such testing times. The delivery app has taken up its mission of corporate social responsibility (CSR) in a bid to provide relief to people struggling with this pandemic in Pakistan.
foodpanda has come out with a plan and teamed up with multiple NGOs including Saylani Welfare, UNAP, Shaukat Khanum, Indus Hospital and others. This service will support and raise money for the daily wagerers of Pakistan who have been affected most by the pandemic.
So how will it work? Simple. The foodpanda app will feature NGOs stated above as restaurants to raise funds. All you have to do is open the NGO you find most suitable and donate generously for the noble cause. The amount you donate will be added as a menu on the NGO's respective landing page. The mode of payment can be online payment or cash on delivery.
Furthermore, the second phase of foodpanda's CSR focuses on providing free meals to our warriors, the frontline workers. This includes all types of medical staff who have been fighting the coronavirus tirelessly.
Not just medical professionals, but law enforcement agencies working for a smooth flow of operations are included in this activity as well. foodpanda is providing free meals to all these professionals, so they too feel that we care!
So, what are you waiting for? Order now for yourself and others who need our support in these tough times.


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If you ever dreamed of waving goodbye to the city in exchange for the quiet farm life up north, this St. Helena home might be the ticket. It has all the bucolic vibes but with polished amenities and no pesky farm animals.
An all new construction, this four-bedroom home is fashioned after the iconic farmhouse (it has a classic board and batten exterior and a corrugated metal roof) but is designed for modern life.
Olive trees and rose bushes surround the home and its ample spaces for outdoor entertaining, including a pool, patio and backyard where an outdoor kitchen is primed for Wine Country summer parties.
Inside, meanwhile, it's all R&R. In the master suite, vaulted ceilings lend the feeling of country charm; deep pile carpet feels plush between your toes; the bathroom has a luxurious freestanding tub, dual-sink vanity, and walk-in shower; and French doors open onto the pool.
For the chef of the house, the contemporary kitchen has all new stainless steel appliances, a built-in refrigerator, and a large custom island just waiting to be piled high with snacks. Sounds just perfect for settling down and making babies, no?
If you decide to go that route, call mom and dad and ask them to come and stay for a bit. The one-bedroom guesthouse has ts own bathroom and plenty of space (536 sq. ft.). It's nicer than most San Francisco million-dollar homes.
Location: 1217 Allyn Ave., St. Helena
Bedrooms: 4
Bedrooms: 5
Asking Price: $3,550,000
Square Footage: 2,322 sq. ft.
// Listed by Nicole Needham, Sotheby's International Reality, nicolejneedham.com


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First flap. Issued 1 per life no trading. Used from 1954-1963.
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President-elect Joe Biden has said he will put democracy front and centre of US foreign policy. But after the turbulence of recent years, reversing the global trend towards autocracy will need a strategy and strong alliances. What do we know about his plans?
It is tempting to think that the Biden administration will simply turn back the clock in its foreign policy – re-joining the WHO, re-committing to the Paris Climate Accords, re-starting the Iran agreement, and renewing U.S. support for NATO and the rules-based international system. But the global context has evolved since Biden was last in the White House and his pledge to host a Summit of Democracies is a clear signal that he sees a decline in democratic values as a threat to US and Western interests. If the Summit is held while the UK is chairing the G7 and COP26 next year, then transatlantic collaboration will be key to its success.
Join us in this live online event as our top guests unpack and explain the key pillars of Biden's plans to rebuild global democracy and the transatlantic dynamics. Our panellists are either directly engaged in this planning or close observers and can shed light on the key priorities, including human rights, corruption, countering hostile states, and tackling climate change. They can also discuss the mechanics of the transition from the Trump administration and what we can expect over the coming months.
- Dr Frances Z. Brown, Senior Fellow, Carnegie Endowment for International Peace
- Alex Thier, Senior Democracy Fellow, Freedom House
- Anthony Smith, Chief Executive, Westminster Foundation for Democracy (Chair)


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photo credit: Getty Images
Offset found himself in some heat when he smacked away a fan's phone and now the police are after him. Travis Scott and Kylie Jenner celebrated La Flame's birthday by getting matching tattoos, Cardi B makes noise for her BBMA's acceptance speech and social media.
This week, Bryhana also fills you in with the news that Offset wasn't the only one in trouble with the law, but Souljaboy was sentenced to 240 days in slammer for violating his probation.
While some of your favorite rappers are in trouble with the law, there was a lot of new music that dropped this week as well, including Blueface's "Stop Cappin", new music from YG, Tyga, Mustard, and Logic featuring Eminem.
Bryhana also shares how Taylor Swift was getting dragged on social media since most of the Beyhive was saying the country singer ripped off Beyonce's 'Homecoming' Coachella performance.
Peep all the interview highlights featuring Julio Macias, Sean Paul, and more below in this week's Power On installment.


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Ready to give rehab a try? Maybe it's been quite a difficult struggle for you to get to this point. But if you have made the decision that getting clean and sober is definitely on your agenda, this is quite a singular accomplishment. Still, your motivation for recovery is faltering. Now is when the hard work begins. Before you get cold feet and make a rash decision to chuck the idea of rehab and put it off for another time, consider that there really is no better time than the present. You might think that you don't have the motivation to stick with rehab, rationalizing that you'll probably quit halfway through, so what's the point? You might, on the other hand, force yourself into rehab for better or worse, either because others will make your life a veritable nightmare if you don't, or you just feel like you have to get this monkey off your back. Guess what? Rehab isn't really an all or nothing proposition. In fact, it isn't a proposition at all, but rather a process. And the best part is that a more moderate approach may very well work the best for you in rehab. Confused about what this means? Worried that is sounds more complex than you bargained for? Put your confusion and worry aside. Here is some information that will help ease your mind and make you feel better about your decision to go into treatment. Remember, your motivation in recovery comes from small success, not an all-at-once finish line (which is impossible).
Choose a Rehab Facility that Motivates Your Recovery Journey
There are lots of sites offering advice on how to choose the best rehab facility for your particular addiction or addictions. While much of what is written is very good to consider — whether it centers on getting a good feel for what the treatment center has to offer and whether or not you feel it is a good fit for you, to finding out if your insurance will pick up the cost or most of the cost of rehab, to what kind of leisure time activities are offered, to your living accommodations while you are in treatment – all of these are ancillary to the key point about choosing a rehab facility. It has to be the right one for you. What does this mean? How can you know if a rehab facility is the best one for you? In a way, you have to go with your gut. Does one particular facility inspire you toward recovery? That's after you've put in the time and done your research to get answers to all the pertinent questions, like those listed above. Why all the fuss about getting it right as to your selection of treatment facility? Actually, there's a very good reason for it. You will be spending some time in rehab, first to detoxify and get all the toxic substances out of your body, and then to go into therapy – the crux of the rehab process – to learn how to overcome your addiction. Note that nowhere is there any guarantee of success. You can go to the most celebrated treatment center there is, one with stellar credentials and a terrific track record. But if you don't do the work and put yourself 100 percent out there, the results may not be what you want or expect. How successful your rehab is will depend on you. That's it in a nutshell.
Choose a Rehab Like You'd Choose a University
But this doesn't mean that you can just go anywhere and the process will work the same. Rehab centers are like people in that they each have different personalities. As such, doesn't it make more sense to select one that is more in tune with yours? Once you start looking into what's available, you'll come to some conclusions pretty early on. It won't be all that tough to single out several that you'll want to check out further. From there, it's a weeding out process to arrive at the one rehab facility that offers the best of all your requirements. It may not be the most expensive or it might be. It may be more Spartan than luxury. It may be in state or several states away or on the other side of the country. It may specialize in many different areas, including the one you seek treatment for, or it may be a facility dedicated to your particular addiction alone. Think of this as similar to choosing the right university or college. This is a significant investment, both in time, money and effort. You want to get it right. What you will learn during rehab will help establish your foundation to begin recovery. Keep your options open until you need to make a decision. Then, make your choice and don't look back.
Finding Rehab Too Tough To Handle
Once in rehab, you may find recovery motivation drops again. Let's say that you enter rehab, go through detox, and begin the one-on-one therapy sessions with the counselor assigned to you. At first, it may seem strange and not all that comfortable to be in the presence of a stranger and to talk about your life in addiction. You may be tempted to keep things back and, if you're like many first-timers to rehab, you probably do. But somewhere along the way during these sessions with your therapist, you may find that it's getting just a little too tough for you to handle. You don't like the line of questioning. You really don't want to go through the exercises and homework. And you most definitely don't want to revisit painful memories of your past. What you do feel like doing is bolting out of there. Before you ditch rehab, however, take the time and make the effort to talk with your therapist about your discomfort. This is, after all, your rehab. Your therapist isn't in this to see how much he can dig out of you or to make your life miserable while you're in treatment. The whole purpose is to help you gain some insight into why you've been doing what you've been doing, to encourage you to look at alternatives, to make better choices, and to have hope that your life in sobriety can be fulfilling and stable.
Make a Therapy You're On Board With
Working with your therapist, you can come up with a plan and decide upon an approach that works better for you. This is what it's like to adopt a more moderate approach in rehab. It isn't all gung-ho and there's only one way to proceed. Rehab doesn't work that way – at least, effective rehab isn't like that. Ask yourself, though, if you are rebelling against the questions your therapist is asking because you don't want to go there, or is it that it is truly painful and you need to take a slower pace? You might be engaging in self-denial, telling yourself and your therapist that you don't have a problem with this or never struggled with that, when in fact, you really have and do need help with this area of your recovery process. Remember that one-on-one counseling is one of the most important parts of the rehab process, but it isn't the only one. There is also group counseling or group sessions, where you'll participate along with others who are also in rehab. From time to time, there may be some personality conflicts or clashes during these sessions, but these too should not deter you from sticking with rehab. Talk with the group facilitator, your therapist, or someone of authority at the rehab facility if things get out of hand. Just make the decision to remain in rehab. It isn't all that much time away from your life, but what you learn during rehab may very well be some of the most important information you've ever learned.
Don't Give Up When Things Don't Seem to Be Working
When you enter rehab, you'll probably hear about a number of different therapies that the facility uses. Most addiction treatment facilities use a multi-disciplinary approach that combines many therapies, all tailored to the patient's particular needs. That is because this has been proven to be the most effective in helping individuals learn to overcome addiction. There is no single approach that works for everyone. That said, it is important that you recognize that your personalized treatment plan may call for you to start off with one or two therapies, in combination with one-on-one counseling, group sessions, recovery literature reading and some leisure activities. You may also be prescribed medication to help counteract or minimize the effects of withdrawal, to help ease your anxiety or for some other reason. The combination of your prescribed medication and the various therapies may not be as effective as they could be. It isn't that there is anything wrong with them, just that the results aren't forthcoming. Again, working with your assigned therapist, who will be doing regular reviews of your progress, some changes can be made to substitute other forms of therapy or to add to what you currently have.
Exercise Patience in Your Recovery
The point is that there are many therapies available to help you in rehab. You don't have to worry that if one doesn't work, all is lost or that you've wasted your time at the facility. If you have a problem or if you don't think you're getting anywhere with the therapy or therapies, discuss it with your therapist. Something can always be worked out. Remember that it isn't an all or nothing approach when it comes to the therapies you participate in. There may be something standing in the way of your being able to make progress. You might, for example, have experienced significant trauma in the past or suffer from post-traumatic stress disorder (PTSD). One therapy that's been proven effective in dealing with both is eye movement desensitization reprocessing (EMDR). Such a therapy can help you move past those painful memories and begin to get on with your life. This is just one example of the many different therapies and therapeutic approaches that are available in rehab.
Recovery Motivation Reminder: Rehab Is Only the Beginning
Another critical area in rehab is how you believe you are doing. For many who are experiencing rehab for the first time, it often seems as if things aren't moving along as fast as they should. What people don't realize, however, is that rehab is just the beginning of the process of overcoming addiction. It takes time to learn how to manage your life once you are clean and sober. You have a lot of bad choices that you need to learn how to substitute healthier choices for. When you feel like rehab is a waste of time or that you should be able to "get it" quicker than you are — remember this: what you are doing here during rehab is just the beginning. No one really walks out of a treatment facility with absolutely everything figured out as to how they're going to live the rest of their lives. How could they? For one thing, they've just gone through rehab. For many, this is the first time being sober in many years. There is a lot they have to learn and rehab is just the start of the process. This doesn't mean that you should shortchange your expectations of what rehab can do for you. Give yourself every opportunity to learn as much as you can while you are in the safe and secure environment of the rehab facility. Take advantage of the time you have with your therapist. Use your precious sessions to delve deeply into what's been troubling you. While you may come away with many more questions that you came into the session with, this is good because it motivates you to begin thinking more strategically about your part in your recovery. Will you know everything you need to know at the conclusion of rehab? No, of course you won't. But you will know a great deal, even if you've only gone into rehab because you were more or less forced to or felt you didn't really have a choice. Everyone who goes through rehab comes away from the experience with more than they entered with. The question is, after rehab is over, what are you going to do with what you have learned? How will you take it to the next level so that you continue making progress in recovery?
Don't Get Off the Emotional Roller-Coaster of Healing
One particular area of rehab that may be somewhat confusing is how you deal with it emotionally. And, let's be frank about it, going through rehab can put you on an emotional roller coaster. For one thing, as the toxic substances begin to leave your body, your senses may be heightened. You may feel emotions you haven't felt for a long time. The sensations may not be all that welcome or pleasant. After all, you've been deadening and numbing yourself with your drug of choice for so long that this flood of emotions may be a bit disconcerting. Keep in mind that you need to be able to feel emotion. Joy, sadness, pain, satisfaction, love, contentment – life is less than complete without being able to experience the full gamut of emotions. Instead of being fearful of your emotions, learn how to welcome their return. Granted, learning how to get a handle on your emotions so that you don't go off the deep end, act inappropriately, or be so afraid of them that you want to revert to your drug of choice just to stop them will take some time. Again, use the time that you have during rehab to talk with your therapist about any emotions that you find troubling or want help with. Above all, remember that rehab is the beginning of your overall healing journey. Emotions play a big part in your healing process. Bottom line: Forget about rehab being an all or nothing, one-time, get-it-right-or-go-home trial to be endured. The best approach for you may very well be a more moderate one – keeping the ultimate goal of getting clean and sober front and center, and picking up as much knowledge about how to live a healthier lifestyle in sobriety along the way. Your motivation for recovery will grow with each small success. And you definitely can do this.


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The courts in the US today have delivered the ruling in the case of Lenz v. Universal. The facts of the case are quite simple. The Plaintiff posted a home movie of a toddler dancing in a kitchen to a song by Prince entitled 'Let`s Go Crazy' on YouTube with the aim of sharing the video with her friends and relatives. Universal Music Corporation ('Universal'), the owner of the copyright in the song, sent a DMCA takedown notice to the user in question. The user contended that the use amounted to fair use and sued Universal on the grounds of misrepresentation under s. 512 the Digital Millenium Copyright Act ('DMCA') and tortious interference with her contract with YouTube.
Universal`s defence was that it had no obligation to consider whether or not the use by the use amounted to 'fair use' before sending the notice.
The main question which the Courts had to answer was whether 17 U.S.C. § 512(c)(3)(A)(v) required a copyright owner to consider the fair use doctrine in formulating a good faith belief that 'use of the material in the manner complained of, is not authorized by the copyright owner, its agent, or the law.'
The courts rejected the defence of Universal and ruled that copyright owners need to determine whether or not the use in question is fair use, before sending a take down notice. This is because the DMCA requires copyright owners to act in 'good faith belief that the material in the manner complained of is not authorized by the copyright owner, its agent, or the law.' Hence to do this, the owner must evaluate whether the material makes fair use of the copyright.
This ruling is one that is grounded in logic and correct application of the legal principles as otherwise copyright owners can send takedown notices even in cases where the use in question does not infringe their copyright.


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The Izu Peninsula in Shizuoka is mostly famed for its hot spring and beach resorts, pulling in huge crowds from nearby Tokyo on weekends and holidays. However, Izu has a lot more to it than meets the eye.
If you look further, you'll find it's the home of one of Japan's most famous exports, the well-known sushi complement — wasabi. If you go deeper into the mountains, you'll find so much more.
Kawazu-zakura: One of Japan's Earliest Blooming Cherry Blossoms
If you time your visit right, you may catch the Kawazu-zakura cherry blossom when it's in full bloom. This particular type of cherry tree is native to Kawazu town in Izu and is one of the earliest blooming cherry blossom varieties in Japan. The blossoms come in a lovely blushing pink color and generally bloom between early February to early March. The blossoms can last up to a month and when in full bloom they are a true sight to behold.
Good Food, Good Views
Being close to the ocean, Kawazu and other cities dotted along the coast have plenty of good seafood. Zendokodokaien, run by two sisters, is no exception. The restaurant not only serves a selection of locally-caught fish (so local that you can see the fishing harbor from the restaurant) but also has a great view of the Izu islands while you eat. If you're a fan of an ocean view and great food, you may even want to stay there—there is a traditional-style Japanese inn in the same building.
Wasabi: The Real Deal
Chances are that although you may think you've had wasabi before, you probably haven't. Fresh wasabi is completely different from most packaged wasabi that you find abroad, which is usually just horseradish with a coloring agent added. True wasabi is spicy, but also has a mild sweetness to it. If you want to try the real thing, then Izu is your best bet. The area is Japan's number one wasabi growing region and it's not only because of market share, or volume—the area has a longstanding history of cultivating the green root, as well as natural resources perfect for creating a quality product. Wasabi needs plenty of fresh, clean water and the right balance of sunlight.
Why not try your hand at picking your own wasabi, then eating a dish with it at Kawasemi Honkan in Shimizu city? Or, stop by Amagi Wasabi no Sato service area for soft serve ice cream with a dollop of wasabi on it so fresh that you can actually watch the lady behind the counter grate it before she adds it to your ice cream. The spicy burn is softened by the sweet vanilla ice cream and is quite the treat if you're brave enough!
Architectural Masterpieces
Famed for hosting a slew of notable authors, artists, and film stars, Ochairou Murakami is no ordinary ryokan. While other traditional-style Japanese inns may boast lovely views, great food, hot baths, and a comfortable stay, Ochairou Murakami offers that and much, much more. Architect nerds, in particular, will find this inn a stunning and rare example of Japanese ingenuity and craftsmanship. The inn boasts several cultural heritage and architectural designations. Shoji screens like the one pictured above are constructed by hand and allow only a 0.1-millimeter margin of error — a truly stunning feat. Not only that, but many of the designs featured are very rare, some hailing their influence from the art nouveau movement. And that's only the tip of the architectural iceberg — there are so many other amazing design aspects they simply must be discovered in person. If you're looking for a Japanese inn that excels in everything, this is the place to be.
Cyclist Wonderland
But Izu isn't all food and flowers. Izu city is the home of the Tokyo 2020 cycling races and has a velodrome (cycling arena) designed by world-renowned architect Ralph Schuermann, who also constructed velodromes used for the Rio Olympics in 2016 and the 2008 Beijing Olympics. Izu's velodrome was finished as recently as 2011 and was the first wooden track cycling arena to be built in Japan. Visitors can stop by anytime during opening hours, even when a race isn't on. If you're lucky, you may spot some future Olympic athletes training on the track!
Izu city plans to make the area more cyclist-friendly over the next few years by creating cycle route maps, as well as constructing roadside service areas exclusively for cyclists.
Tofu and Wasabi — A Match Made in Heaven
Sitting beside the Kakitagawa river — known for its fresh, clear waters — is Kakitagawa Usuinomichi, a mini wonderland of delicious tofu and soy products, as well as rich cultural experience. The area not only offers a spectacular view of the cool waters of Kakitagawa, visitors are also welcome to drink some of the water firsthand. Kawasemi Honkan, the main restaurant the, makes use of this clean river water when cooking its delicious (and very reasonable) tofu set lunches. For those lucky enough to go wasabi harvesting the day before, guests can eat their tofu seasoned with freshly grated wasabi that they picked themselves.
Great Views of Mount Fuji
If you love landscape photography, then Izu is the perfect place for you. Not only does the peninsula have the previously mentioned beaches and hot spring resorts, it also has a multitude of viewing points of Mount Fuji. Izunokuni Panorama Park offers a stunning view of the mountain, together with Suruga Bay. It also has a tiny shrine that has been there since the Heian period, as well as a hot spring to dip your feet in as you take in the view.
Also, the recently-opened Mishima Sky Walk boasts another great view of Mount Fuji and Suruga Bay, coupled with fields of beautiful flowers, all viewable from a 400-meter long pedestrian suspension bridge—the longest in Japan! The nearby shops are also chockablock with souvenirs and local delicacies, including a giant ichigo daifuku—that's a strawberry wrapped in mochi—and a seriously luxurious public bathroom; complete with scented toilet paper! Don't believe me? Go see for yourself—you can thank me later.


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Naming this bakery after the road name couldn't be more appropriate to characterize this modernized coffee shop. (Didn't Tiong Bahru Bakery do the same few years back?)
Keong Saik Bakery showcases glimpse of traditional vibes through their contemporary bakes and coffee.
Upon stepping into the place, you will be greeted by a huge mural wall which contains historical information that would shed some light on Keong Saik Road's heritage.
While updating yourself on history lessons, your sense of smell will then be tickled by the buttery fragrance from the bakes together with aroma of Nanyang Old Coffee.
For those who need your traditional coffee, kopi-o and teh-o are available.
There is also the option of extracting traditional blends using espresso machine to achieve a darker roast version of "flat white" aka kopi-susu.
Power caffeine fix, I like.
Their range of bakes comes with interesting naming and oriental flavors.
For instance, XO Lap Cheong (Cured Sausage) with cheese, Orh Tao Roti (Yam), and Pineapple Melon Pan.
I went for their signature item, Sor Hei ($3.60), which was named after the traditional ceremony 梳起 (Combing-up) as a tribute to the previous shop owner who was a Majie (妈姐) – traditional women who worked as domestic workers and vowed not to get married.
This was represented by the black and white Danish pastry with chocolate chip, which was molded into the shape of hair combed in a bun.
I liked its flaky crust which came in an abundance of buttery fragrance together with melted chocolate chips. But I secretly wished for more chocolate chips which would provide additional bite texture.
Another creation which caught my attention was the Cute Green Egg Bun ($2.80), a soft fluffy bun which encased oozing matcha salted egg fillings. *slurps*
The lava filling was not overly sweet, and I liked that they sprinkled the bun with a layer of matcha power for a hint of bitterness.
The bakery cafe has also caught up with food trends, and has launched its version of Dirty Breads 脏脏包 – which is supposed to make a mess around your mouth after eating them.
The Matcha Dirty Bread ($4.50) contains drizzles of matcha sauce and Uji Matcha powder sprinkled on top. Also available is a chocolate version.
But if I were to recommend, it would be the Matcha Swiss Roll – soft fluffy sponge cake rolled up with fresh matcha cream in the middle, with matcha powder to create that 'dirty' effect.
Liked that it was not too sweet as well, best paired with their strong kopi.
On a side note, Keong Saik Bakery offers all-day breakfast set which comes with a selected bread of choice, coffee and 2 soft-boiled egg at $5.
For the quality of bakes, I would say it is quite value for money.
Other than bread, they also have a selection of cakes which carries a slight Asian touch. Flavors such as Gula Jawa Sticky Rice (Coconut Sugar), Lucy (Pandan Cheesecake) and Golden Blossom are (Chrysanthemum) available from $5.50 onwards.
Their best seller Chendol Delight ($6.50) probably resonated well with the locals with its rich and smooth coconut custard embedded with red bean, attap chee and topped with pandan jelly.
Flavorsome, but it does gets heavy on the palate after a few mouthful. Maybe they can consider going easy on the sweets?
I love how they incorporate localized ingredients into cakes to give a new leash of life to the product.
Keong Saik Bakery
33 Keong Saik Road, Singapore 089140
Opening Hours: 8am – 6:30am (Mon), 8am – 8:30pm (Tues – Sun)
Keong Saik Bakery – Holland Village
44 Jalan Merah Saga, 01-42, Singapore 278116
Opening Hours: 8am – 6pm (Sun – Thurs), 8am – 9:30pm (Fri – Sat)
Other Related Entries
Tai Cheong Bakery Singapore (Takashimaya)
Out Of The Cakebox (Our Tampines Hub)
Salt And Delight (Yio Chu Kang)
April's Bakery Singapore (Tampines)
Nesuto (Tras Street)
* Written by Lewis Tan @juicyfingers, a self-proclaimed coffee addict. Daniel's Food Diary pays for food reviewed unless otherwise stated.


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Friday, September 27, 2019 at 2:38pm.
CX Obsession
Someone will be stationed at the front door of the Vacasa office to let you in and badge you up the elevator.
CX Obsession is a meetup for Customer Experience professionals and a showcase of brands doing awesome, innovative work in CX.
In Hospitality, experience is everything. So what can we learn from the industry that all but invented Customer Experience? AskNicely presents CX Obsession, an evening with four customer-obsessed hospitality brands relentlessly focused on delivering amazing experiences. Hear from the experts what sets them apart in their quest for the ultimate experience. You will walk away inspired and with a few new ideas to apply in your own practice, whatever your industry.
Taking place in Vacasa's beautiful Pearl District office space, come to CX Obsession ready to exchange questions, stories, and ideas with those just as customer-obsessed as you are. We'll provide the drinks and snacks.
Here's what we have planned:
5:30pm - 6:00pm Registration, Drinks & Appetizers: Check in and network with the CX Obsession community while you grab a bite to eat and drink.
6:00pm - 6:50pm Inspiring talks and a panel discussion/Q&A with our speakers:
Liz Walker, Product Lead — Airbnb Nate Tomlinson, Director of Customer Experience — Vacasa Chris Bebo, Director of Operations — Provenance Hotels Sean O'Connor, General Manager & Partner — KEX Portland
6:50pm - 7:00pm Debrief: In small groups, take a moment to reflect on what you've heard and share your observations. Write down one action item or takeaway that you will take back to your organization.
7:00pm - 7:30pm More Drinks, Apps, and Networking: Grab a few more nibbles and chat with your peers as we close out the evening (or take a peek at the view from the gorgeous rooftop patio!).


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Anti-Alemtuzumab ELISA Assay Kit
The Anti-Alemtuzumab ELISA Assay Kit is For Research Use Only
Size: 12×8 wells
Sensitivity: <10 ng/mL
Standard Range: 10-640 ng/ml
Incubation Time: 2.25 hours
Sample Type: Serum, Plasma, Cell Culture Supernatants
Sample Size: 100 µL
Alternative Name: Lemtrada
Assay Background
Alemtuzumab is a fusion protein produced by recombinant DNA. It fuses the TNF receptor to the constant end of the IgG1 antibody. First, the developers isolated the DNA sequence that codes the human gene for soluble TNF receptor 2, which is a receptor that binds to TNFα. Second, they isolated the DNA sequence that codes the human gene for the Fc end of immunoglobulin G1 (IgG1). Third, they linked the DNA for TNF receptor 2 to the DNA for IgG1 Fc. Finally, they expressed the linked DNA to produce a protein that links the protein for TNF receptor 2 to the protein for IgG1 Fc. It has U.S. F.D.A. approval to treat rheumatoid, juvenile rheumatoid and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis. TNFα is the "master regulator" of the inflammatory (immune) response in many organ systems. Anti-Drug Antibodies (ADA) may induce unwanted side effects in biopharmaceuticals. Hence, ADA has been subjected to increase in scrutiny by the regulatory authorities using immunogenicity safety studies. ADA has been observed in pre-clinical and clinical studies, resulting in significant changes in toxicology, pharmacokinetics and efficacy. These effects result from the generation of drug-induced (neutralizing) autoantibodies against Alemtuzumab and can be responsible for allergic reaction, or even anaphylactic shock. This ELISA kit detects antibodies for Anti-Alemtuzumab and may be used for monitoring immunogenicity.
Related Products
Alemtuzumab ELISA Assay Kit
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Anti-Ustekinumab (Stelara) ELISA Assay Kit