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Journal of Agricultural Chemistry and Environment
Vol.07 No.01(2018), Article ID:81996,11 pages
Stereospecific Degradation of Diastereomers by Plant Associated Bacteria Influences the Antifungal Performance of Dodemorph*
Gyula Oros
Plant Protection Institute, Hungarian Academy of Sciences, Budapest, Hungary
Copyright © 2018 by author and Scientific Research Publishing Inc.
This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).
Received: December 14, 2017; Accepted: January 22, 2018; Published: January 25, 2018
Morpholine fungcides have certain antibacterial side effect, dodemorph being the most active among them. The diequatorial (cis-) form of dodemorph expressed higher antibacterial activity than the axial-equatorial (trans-) form, and no synergy in their joint action could be revealed in this respect. Moreover, the partition of diastereomers between cells and medium strictly correlated to their toxicity. Considerable differences were detected among degradation rates in various bacteria, and the meso-(RS)-diastereomer was deteriorated more intensively, then the trans-(SS and RR)-forms in Corynebacterium betae, Erwinia uredovora and Pseudomonas fluorescens. As a result, the stereospecific degradation of diastereomers changed their ratio in the medium, thus this metabolic step could influence the antifungal performance of dodemorph based preparations against filamentous fungi. It was demonstrated that due to synergic joint action, the fungistatic effect of morpholine derivatives noticeably increased against Botrytis cinerea by changing the ratio of diastereomers.
Fungicide, Diastereomer, biodegradation, bacteria, fungi, Synergy, stereoselectivity
1. Introduction
The morpholine derivatives have been introduced against powdery mildews [1] . These compounds inhibit steroid biosynthesis [2] [3] and lipid peroxidases [4] [5] , moreover, they can disturb the semipermeability of plasmalemma by selectively coupling to phospholipids [6] and alter the activity of Mg2+-dependent ATP-ases as well [7] . Their use was declined after discovery of benzimidazole [8] [9] and triazole fungicides [10] , however, due to rapid development of acquired tolerance to highly specific monosite inhibitors in populations of target microbes, the importance of morpholines is recently increasing. The morpholine fungicides exhibit activity against Gram positive bacteria [2] and some Gram negative species [11] [12] being stereospecific in most of cases [13] .
The aim of these studies was to elucidate the importance of stereochemistry of the methyl groups on morpholine ring (Figure 1) with special regard to possible consequences in fungicidal performance of dodemorph.
2. Materials and Methods
2.1. Compounds and Microbes tested
Marketed products, Calixin 75 ec (tridemorph, CASN: 24602-86-6), Corbel 75 ec (fenpropimorph, CASN: 67564-91-4) and Meltatox 40 ec (dodemorph, CASN: 1593-77-7) as well as their active substances were used for testing antimicrobial activities. The analytical standards were gifted by producer (BASF, Ludwigshafen, BRD).
The diastereomers were isolated as follows: Appropriate amount of formulation (4 g of suspected active substance) was added to aqueous sodium carbonate (15% w/v; 100 mL) and the mixture shaken with ethylacetate + cyclohexane (1:1 v/v; 200 mL). The organic phase was removed and treated with active carbon (200 mg) and magnesium sulphate (5 g), then the volume was reduced to 15 mL in rotary evaporator. This mixture was subjected to column chromatography on Kieselgel H, the diastereomers being eluted with dichloroethane + cyclohexanone + ethylacetate + acetone (48 + 50 + 10 + 2 by volume), and were identified by their physicochemical characteristics [10] .
The microbes used in toxicity were of the collection of Plant Protection Institute HAS (WDCM824).
Figure 1. Enanthiomers of dodemorph. ACD ChemScetch 2012 was used as graphic tool for drawing and stereochemical labeling. Only one enanthiomer (RS) exists in the case of cis-(diequatorial)-diastereomer (meso-form) due to inner symmetry at N → O axis in mor- pholine ring, contrary to trans-(axialequatorial)-form, which has two enanthiomers (SS and RR, respectively).
2.2. Toxicity Tests
The bacteria (listed in Table 1) were maintained on nutrient agar slants and cultured in nutrient broth containing Bacto peptone, Yeast extract (Difco), glucose and glycerol (10, 1, 3 and 1 g∙L−1, respectively) and KH2PO4, KCl, MgSO4, CaCl2, NaCl and Fe3+ citrate (0.55, 0.425, 0.125. 0.125, 0.1 and 0.005 g∙L−1, respectively). Hoagland Arnon's micoelement solution was also added (1 mL pro 1 L). Solid media were prepared by incorporating agar-agar (Oxoid; 15 g∙L−1) into this solution.
Standardized bacterial suspensions for minimal inhibitory concentrations (MIC), and "degradation" tests were prepared by washing cells from 20 h old culture on solid medium (5 mL in a tube) with sterile liquid medium (5 mL). The optical density of the suspensions was determined (520 nm; Unicam SP 800) and water than added to give a final OD600 of 0.4 - 0.5. Such suspensions were prepared for each species tested, and added to wells of multipoint inoculator cooled to 1˚C - 4˚C.
Minimum inhibitory concentrations for bacteria were determined by adding the appropriate compound in sterile distilled water to nutrient agar (30 mL; 45˚C), mixing well and dispensing aliquots of the resultant mixture into each of two Petri dishes. These were inculcated with the standard suspension of the appropriate bacteria using a multipoint inoculator. Dishes were incubated (25˚C ± 2˚C) and bacterial growth evaluated after 48 and 96 hours on the scale 1 - 4, where 1 represented stimulation, 2 similar to and 3 retardation of growth com- pared with that on the control and 4 represented no growth. A series of concen- tration (1000/2n mg∙L−1, n = 0, 1, 2, ..., 21) were tested.
The fungi, Aspergillus niger van Tiegh., Fusarium graminearum Schwabe, F. oxysporum Schlechtendahl, Chaetomium globosum Kunze, Botrytis cinerea Pers., Thielaviopsis basicola (Berk. & Broome) Ferraris, Rhizoctonia solani Kühn, Trametes versicolor (L.) Lloyd, Pythium irregulare Buisman and Phytophthora cactorum Pethyb. were maintained and cultured on home prepared potato dextrose agar (PDA) slants amended with mineral salts listed above and sodium nitrate (2 g∙L−1). The broth was prepared from peeled potato tubers (200 g) cut into pieces (approx. 1 ´ 1 ´ 1 cm) and cooked in 1 litre of distilled water (20 min) then filtered through a Perlon meshwork (No. 500) and the filtrate was then made up to 1 litre with distilled water.
The fungictoxicity of compounds was characterized by ED50 values (mg∙L−1), calculated from radial growth inhibition rates expressed as percentage of control grown on poison free medium. The synergetic character of joint action of diastereomers was tested according to either Colby [14] or Sun [15] . The comparative toxicity index (Co.T.I.) was calculated using ED50 values as follows: Co.T.I. = (1/F)/((a/C) + (b/T)), where F, C and T are the ED50 values of the commercial product (F) and single diastereomers (T = trans- and C = cis-, and a and b their weight ratios in the active ingredient of marketed fun- gicide.
2.3. Degradation experiments
Standard suspension of bacteria (5 mL) was added to nutrient broth (150 mL) in 500 mL Erlenmeyer flask and the whole incubated on a rotary shaker at 24˚C for 22 hours (A tumefaciens, E. uredovora, P. fluorescens and X. vesicatoria) or 44 hours (C. betae). The resulted suspensions were centrifuged (10 min, 9000 g), the pellet washed with sterile medium (without peptone and yeast extract), and the residue weighed. All operations were performed at 0˚C - 1˚C, and the medium was adjusted to pH 6.8 prior use. A portion of the cells (500 mg) was added to the medium (25 mL, without peptone and yeast extract) to give the working suspension used for studies of partition coefficient and degradation.
The acetonous stock solution of the appropriate compound (500 μg) as added to the working suspension, mixed well, and the suspension incubated on a rotary shaker at 27˚C ± 1˚C for 5 hours. The suspension was then cooled melting ice bath to 0˚C and centrifuged (10 min, 9000 g) at 0˚C - 1˚C. The supernatant and residual bacteria were analyzed separately.
2.4. Analytical techniques
Silufol UV254 plates (Cavalier, Votice, Bohemia) with benzene + ethylacetate (78 + 22 v/v) as mobile phase were used for purity test, where diastereomers were visualized with iodine vapor as well, the minimum quantity detectable being 0.1 μg (10−6 mM).
Packard series 7400 instrument equipped with a flame ionization detector, and 180 × 2 mm I.O. glass column packed with 3% OV-1 + 1.5% OV-225 on Gaschrom Q (80 - 100 mesh) were used for separation of diastereomers. The detector and injector temperatures were 235˚C. The column temperature was changed at 10˚C min−1 from 150˚C to 220˚C after 4 min initial hold and 9 min final hold. 5 × 10−6 g of compound were injected in 5 microlitre, final resolution power 3 × 10−9 as the final point of the calibration curve.
For determination of the quantity of test compounds in medium of degra- dation experiments 0.5 mL acetone and 2 mL saturated sodium sulphate con- taining 5% v/w sodium carbonate was added to the supernatant, which was then extracted with 1.0 mL of cyclohexanone + ethylacetate + toluene (5 + 1 + 5 v/v) and the organic phase used for GC analysis immediately. The degradation rate was calculated from the analytical data as a difference of test substances applied and that in the supernatant and in the bacteria after 5 hours incubation.
The bacterial residue was suspended in distilled water (0.5 mL), then acetone (0.5 mL) added and the mixture kept in boiling water for 3 min. Distilled water saturated with sodium chloride (4 mL) were than added, and the resulting suspension extracted as above. The organic phase was subsequently analyzed by GC. The distribution of test chemicals between bacterial cells and medium was expressed as K;
K = [concentration (microg/g) in the cell]/[concentration (microg/mL) in the medium]
and K was a measure of uptake of the investigated substance into the cells.
2.5. Data treatment
All experiments were carried out at least in triplicates. Student's t was used to evaluate significance of differences between average values, and Fisher's test was applied to reveal impact of alterations in structure of test compounds at P = 5% level.
3. Results and Discussion
3.1. Toxicity
Meltatox proved to be most effective against bacteria surpassing Calixin or Corbel (Table 1). In general, the Gram positive bacteria were essentially more sensitive to morpholine fungicides than Gram negatives. Although, no data are available for the intrinsic activities of formulants, seemingly all test microbes tolerated well the carriers used for preparation as only at high concentrations were revealed minuscule differences between commercial products and their active ingredients. The diastereomers had different toxicities (Table 1). The most effective cis-form seems to be responsible for the toxicity of formulated product, Meltatox 40 ec, Agrobacterium, Erwinia and Pseudomomas spp. The cis-form is also more toxic to Xanthomonas species, while Gram positives exhibited differential sensitivity.
Differential sensitivity was also demonstrated among fungal species investigated in vitro (Table 2). Calixin 75ec was most toxic to the majority of fungi, while Meltatox 40ec and the constituent dodemorph diastereomers proved to be the least toxic. Although, in several cases significant difference of activity could not be revealed between diastereomers, their mixtures always exhibited higher toxicity. The synergy varied within large limits, and it was outstanding in the case of B. cinerea. The stereoselective antifungal activity is not a proper character of dodemorph as it was similarly elucidated in the case of tridemorph diasteremers as well.
3.2. Uptake of diastereomers intobacterial Cells
Uptake of diastereomers into bacterial cells was very different with the representatives of the five genera tested and seems to be proportional to their sensitivity (Table 3). The trans-form was accumulated much more than the cis-form and the ratio varied a little. This enrichment with a particular diastereomer was inversely correlated with lipophilicity over a range of pH. The cis-form is 2 - 4 times more lipophilic than the trans one. Cells of these bacteria are surrounded with a hydrophilic capsule having acidic character. This capsule is clearly the first barrier to permeation of the molecules into the cells. Perhaps this is the cause of the inverse correlation between the lipophilicity of dodemorph isomers and their accumulation in the cells. The effect of cell wall and mucous capsule can be possibly influenced by the change of the pH which depending on the
Table 1. Growth inhibitory effect of morpholine derivatives towards bacteria.
Code numbers of Agrobacterium, Bradyrhizobium, Rhizobium, Erwinia, Pseudomonas, Xanthomonas and Corynebacterium strains were given by identifiers. n.t. = not tested.
Table 2. Inhibitory effect of morpholine fungicides and their diastereomers on the radial growth of fungi.
The body of the table comprises ED50 values (mg∙L−1) and comparative toxicity indices characterizing the joint action of diastereomers. Corbel 75ec containes only cis-fenpropimorph. Example for calculating Co. T.I = (1/0.33)/((0.6/7.8) + (0.4/14.8)) = 28.9 in the case of B. cinerea. The joint action is synergic when Co. T.I. > 1.0, and antagonistic when Co. T.I. < 1.0, while the effect is considered to be additive when Co. T.I. = 1 ± 0.05.
Table 3. Uptake and degradation of dodemorph diastereomes in bacterial suspension.
aA. tumefaciens C58, E. carotovora, P. fluorescens, X. vesicatoria and C. betae were used for experiments. bThe medium was acidified during the incubation at species dependent manner. The pH of the bacterium suspensions was 6.8 at the start of incubation, and the degree of ionization was 50 and 28.9 % of cis- and trans-diastereomers, respectively.
species drops during the incubation from the original 6.8 to 4.1 - 5.5. We can suppose the existence of pH gradient (changing during incubation) via medium/outside of mucous capsule to inner side of plasmalemma, which can change the degree of ionization of capsule-cell wall and both diastereomers. In the last case the change of pH in the medium moves the ratio of cationic form from about 25% to 80% - 99% in dependence of the species and diastereomeric form concerned (pKb values for cis- and trans-forms are 6.66 and 6.29, respectively). As the difference between accumulation of cis- and trans-forms much higher than the difference between their ionization in each proper case, we can suppose, that the selective "accumulation" observed was not due to the fact, that the increased ionization upraises the possibility of bounding a cation, so the inverse "lipophilicity" correlation is not an artifact.
3.3. Degradation
The quantity of both diastereomers was diminished by bacteria in the incubation system during a 5 hours incubation. This phenomenon we could detect only in case of intact cells. For this we suggest that it is the result of the transformation, character of what we did not investigate, because of the instability of the compounds of degradation, however, the original molecules we could resolve with high degree. This made possible to extract information from the analytical data about degradation as the diminishing of quantity can be calculated, that means, the lack of the total quantity of the substance is an indirect characteristic of the transformation activity in bacteria. Degradation rates in absence of stereo- specificity should correspond to the original ratio of diastereomers.
Differences in accumulation of individual isomers per se cause alteration in ratio (cis[RS]/trans[RR]/trans[SS]) of (3 + 3 + 2 + 2) or (cis[R,S] versus trans [RR, SS]) of 3:2. The ratios calculated from the measured values did not correspond to the original one that was altered to the side of lower values speaking about the more rapid transformation of the more active cis(R,S)-form (Table 3). This suggests that the degradation in bacteria means detoxification. The transformation systems of investigated bacterial species distinguished the diastereomers in various degrees, unfortunately, we could not determine the possible change of ratios of RR/SS enanthiomers of trans-form. From measured values after 5 hours incubation it can be supposed, that one of them is more rapidly transformed during 5 hrs of incubation because of the absence of transformation rate significantly more than 50% of transformation.
The cis-isomer was significantly more active than the trans one (tC,T = 7.72, p < 0.05), nevertheless, their ratio in commercial product (3C + 2T) resulted sy- nergic effect in the case of numerous fungi (Table 2) that can influence sig- nificantly the fungicidal performance of marketed product.
The biodegradation not only diminishes the quantity of dodemorph applied, but this stereoselective metabolic process also leads to changes in the ratio of synergicaly interacting diastereomers. Two optimal mixtures with dominating either cis- or trans-diastereomers were found as evaluated with B. cinerea (Figure 2). The growth inhibitory effect of 9:1 and 3:7 cis/trans mixtures did not differed significantly (47.1 ± 2.4 and 45.6% ± 3.2%, respectively, t = 0.74, p > 0.1), and the increase was economically acceptable in both cases. Thus, the most rapid degradation of cis-form as compared to trans-form does not result decreased efficacy of treatment, as the alteration of their ratio of 3:2 to domination of trans-form leads to increase of fungicidal activity, that means, the stereoselective deterioration by bacteria may be presumed as a special type of biactivation. Similar interaction could be revealed between N-alkyl derivatives as well, and the mixtures of corresponding dodemorph and tridemorph diastereomers also formed synergic compositions.
3.4. Future prospects
The development of molecular design opened possibility to reinvestigate the structure/activity relationships of morpholine derivatives, which have special place among systemic fungicides due to lack of acquired tolerance in populations of target phytopathogens. The main targets in filamentous fungi are in steroid metabolism, however, their antimicrobial activity relates also to inhibition of
Figure 2. Evaluation of joint action of dodemorph diastereomers against benomyl tolerant Botrytis cinerea. The experimental model of Horsfall (1945) was applied at 5 mg∙L−1 of active ingredient in the PDA. Lines C and H mark additive effect calculated according to Colby [14] and requested minimum increase in efficacy of mixture requested by re Lemin's case [16] , respectively. IL is the maximum increase in efficacy of mixtures evaluated by Horsfall's model [17] and accepted by US Patent Office as economically approved synergy, while IC is the part of efficacy over additive that does not add significant economic benefit when the two compounds applied in mixture (tC10, C7 + T3 = 0.15, tC5, C3 + T2 = 1.57, tC10, C5 + T5 = 1.36, tC3 + T2 = 0.65, tC10, C1 + T9 = 1.36 < t0.1 = 2.35), according to decision of Worley et al. [16] . Example for evaluation expected activity of Meltatox 40 ec (3cis+2trans diastereomers) at 5 mg∙L−1 by Colby's model [14] : The expected activity = C + T − (C ´ T/100) = 24.3 + 1.5 − ((24.3*1.5)/100) = 25.4%, but the measured one was 30.9% that is 5.5% more than the expected. However, this synergic increase in efficacy does not result economic benefit because the cis-form resulted 34.2% inhibition when applied alone.
various other target sites in metabolism and cell membrane, which can explain their antibacterial activity. Moreover, tridemorph applied in combination with P450 inducer changed the character of host/parasite relationship converting the symptomless sensitive state of plant cells to hypersensitive [7] in the case obligate endoparasites. The mechanisms of cell/cell interaction and nutrition of archeas residing in plants are white fields, but these pathogens might be target organisms to morpholine derivatives as phospholipids selectively interact with these compounds [6] . The special advantage of this group is the lack of their accumulation in the environment or in the food chain due to rapid biodegradation of morpholine derivatives.
4. Conclusion
Interaction between dodemorph disastereomers against bacteria could not be revealed, while the synergic joint action essentially influences the fungitoxic action of the formulated product (Meltatox 40ec) containing their mixture. The stereoselective biodegradation of diastereomers in the case of these compounds is a special type of activation that significantly improves the antifungal performance of dodemorph.
This research work was supported by Chinoin Pharmaceutial Company, Budapest, Hungary.
Cite this paper
Oros, G. (2018) Stereospecific Degradation of Diastereomers by Plant Associated Bacteria Influences the Antifungal Performance of Dodemorph. Journal of Agricultural Chemistry and Envi- ronment, 7, 10-20. https://doi.org/10.4236/jacen.2018.71002
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- 9. Delp, C.J. and Klopping, H.L. (1968) Performane Attributes of New Fungicide and Mite Ovidie Candidate. Plant Disease Reporter, 52, 95.
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*Strereospecific degradation of dodemorph by bacteria.


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The 2nd edition of the UK guidelines for diagnosis, referral and management of CRPS in adults in primary and secondary care has been launched July 2018.
The guidelines originally published in 2012, have been revised to contain updated information and recommendations from a UK panel of experts representing a variety of healthcare specialties and professions.
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The Pain Relief Foundation was pleased to support the revision of the guidelines and was invited to the launch event organised by the CRPS Network and the Royal College of Physicians held on 23rd July 2018 at the House of Commons, Westminster to celebrate their publication. The Chairman of the Foundation Mr David Cain was able to attend alongside Dr Andreas Goebel, Chair of the CRPS Guideline Development Panel and Director of the Pain Research Institute. The event was hosted by Iain Stewart MP and was also attended by other representatives of the professional organisations, patient charities and sponsors who were involved in the development of the guidelines.
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A full copy of the 2nd edition of the CRPS guidelines is available here

subset: commoncrawl


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SANTA CLARA, Calif.—Feb. 17, 2016 — Nexenta (@Nexenta), the global leader in Open Source-driven Software-Defined Storage (OpenSDS), today announced that Adrian Ionel, Founder of Restack, and former CEO and co-founder at Mirantis, has joined the Nexenta Advisory Board.
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Journal of the Masonic Society. Issue 39. Ancient Egyptian sketches by Travis Simpkins |
Thanks to the Journal of the Masonic Society for including my work in the latest issue (Issue 39, Winter 2017). Two of my Ancient Egyptian pieces appear on page 38: a pastel of the famous bust of Queen Nefertiti and a Cat figurine that I sketched at the Worcester Art Museum.
For more info, please visit:


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Today, Reps. Sean Patrick Maloney (NY-18) and Paul D. Tonko (NY-20) introduced legislation to reauthorize two of New York's National Heritage Areas, the Maurice D. Hinchey Hudson River Valley National Heritage Area Reauthorization Act and the Erie Canalway National Heritage Corridor Commission Reauthorization Act. Funding for these heritage areas is set to sunset at the end of this Fiscal Year.
"Maurice Hinchey lived to serve others and protect our environment – he was a model public servant who inspired my own service to the people of the Hudson Valley. It was my honor to immortalize a true legend by passing legislation to rename the area in the 116th Congress. I am proud to be working with Rep. Tonko to reauthorize theses Heritage areas through 2036, allowing them to continue receiving the funding and resources necessary to maintain similar environmentally significant sites across the country. These sites contribute to our local economy and make up the fabric of our community. We can't afford to lose them," said Rep. Maloney.
"America's National Heritage Areas have long stood as historic and treasured sites that support countless jobs, drive economic growth through tourism, foster community activities and child and family education and fun even while they instill in us a deeper connection to the places we visit or call home," Rep. Tonko said. "In our own Capital Region, these legendary sites include the Erie Canalway National and Hudson River Valley National Heritage Corridor. As we continue the work of rebuilding our communities and our economy from the hardships of the COVID pandemic, I am proud to stand shoulder to shoulder with my fellow New York colleagues to push for this needed legislation to maintain a critical lifeline for two of New York's most treasured historic and cultural assets, opening doors for that renewed economic opportunity and a rebirth of community engagement for our Capital Region and beyond."
"We appreciate the leadership of Congressmen Tonko and Maloney in cherishing our interconnected Erie Canal and Hudson Valley heritage. Their visionary efforts are fostering new opportunities for recreation, tourism and economic development that create long-term value for upstate New York communities," said Erie Canalway National Heritage Corridor Executive Director Bob Radliff.
Rep. Maurice D. Hinchey died in November of 2017, after serving the Hudson Valley in Congress and in the New York State Assembly. One of Hinchey's greatest legacies is his commitment to cleaning up the Hudson River and protecting the environment, including authoring the bill that established the Hudson River Valley National Heritage Area in 1996.
The Hudson River Valley National Heritage Area is one of the now 55 federally recognized National Heritage Areas throughout the United States. Through a partnership with the National Park Service, the Hudson River Valley National Heritage Area collaborates with residents, government agencies, non-profit groups and private partners to interpret, preserve, and celebrate the nationally significant cultural and natural resources of the Hudson River Valley. The heritage area is managed by the Hudson River Valley Greenway. More information on the heritage area is available here.


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"Eco is not a bank." – a recurring message one sees on the website of the three-year-old startup building a personal finance app for saving and spending money. Yet Eco takes in deposits, lends them to reap high yields and offers customers savings accounts paying 2.5-5% interest. It also doesn't want to position itself as a cryptocurrency business, yet its revenue model directly depends on the volatile market.
"Sometimes the best way to explain what you are is to explain what you're not. And when you're building something new, like what Eco is, there aren't always the best words for it," says Andy Bromberg, Eco's chief executive.


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DiRT Rally is one of the best modern racing games on PC. It's brutally difficult, but that just makes a flawless run even more satisfying to pull off. The game's latest update might make things a little easier, putting you in the actual driver's seat and letting you more accurately judge distances with Oculus Rift.
For more hot car action, check out our list of PC's best racing games.
We've known VR has been in the works for the racing sim for a while, but it's finally here.
"As you'd expect with VR, the update will immerse players into the world of rally like never before – with the challenge of DiRT Rally taking on a whole new dimension," says the official blog. "You'll be absorbed even further into the game as you take on some of the most challenging real life rally locations in the world, battling the elements in glorious VR.
"And it's not just rally that the VR experience will heighten, either. Ever wondered what it's like to peer over the edge at Broadmoor Pikes Peak International Hill Climb, or look around you on the starting grid of an FIA World Rallycross Championship race? This update will bring Oculus users even closer to these situations and settings, putting them into the heart of the action like never before."
It sounds like it'll be quite the experience. Now we just need a steering wheel that fights back and a chair that throws us around the living room.
DiRT Rally went live on the Oculus Store yesterday, July 11, and the update also went live for existing owners at the same time. There's no mention of Vive support on the blog.
Here's a trailer to get you in the mood:


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Blatsara pie
1kg leaves of green onions
300 gr grated feta cheese
3 tablespoons dill finely chopped
1 cup corn flour (white)
1 cup sweet trahanas (cracked wheat)
1 cup oil
For the porridge:
lukewarm water
a pinch of salt.
Blatsara pie
Wash the onions, chop finely and mix in a bowl with the other ingredients (grated feta-flour-cracked wheat- dill-oil- salt). Prepare the mash, which will take the place of phyllo dough. In a bowl, add 4 glasses of lukewarm water. Slowly add the flour and a little salt, tapping with a fork, until it becomes a mash-like consistency. (not too thick).
Blatsara pie
Baste the pan (which must be dry) with oil and pour in half the mash. Add the filling. Pour the remaining mash on top and spread evenly by sprinkling the pie with enough oil. Bake in medium oven until brown (about 3/4 hour).


text: WATCH: Ex-Brexit minister Steve Baker blasts 'childish' Number 10 over Chequers briefings John Johnston @johnjohnstonmi 3 min read09 July 2018 Steve Baker has accused Downing Street of using "childish nonsense" to pile pressure on Brexiteers, hours after he followed his boss David Davis in quitting the Government. The ex-Brexit minister - who resigned overnight - said he had been left "furious" by a series of heavy-handed briefings from Number 10 ahead of last week's crunch Chequers summit, which triggered the overnight walkout by Brexit Secretary Mr Davis. Ministers were warned that replacements had been lined up for an emergency reshuffle, and journalists were told that resigning ministers would lose the use of their official cars - forcing them to take a taxi back to London from the Prime Minister's Buckinghamshire estate. Mr Baker told the Daily Politics he had almost been pushed to resign over those briefings. "I was furious at the childish nonsense being issued by Number 10," he said. "Absolutely unequal to the task at hand. "Frankly, I was furious, I could have almost resigned over the childishness of that briefing. "There was an untruth told about whether or not I had had promotion dangled in front of me. No such conversation was had. I checked with other colleagues and they had not had conversations about their ambitions tested for promotions." The ex-minister - who exchanged cordial letters with the Prime Minister as he handed in his resignation - also hit out at the Government's sidelining of his department as the crucial Brexit White Paper is drawn up. "I don't think it is too indiscrete to point out that what has happened is that we have all been blindsided by this policy," he said. "We were preparing a White Paper that did not accord with what has been put to the Cabinet at Chequers. "The White Paper we were working on reflected a series of speeches the Prime Minister made, and as has been said, this is a significant evolution from those speeches. "Things have changed considerably this week, and they have changed considerably in a way that I will not be able to represent as my own policy and therefore I cannot be in the government." Asked whether the Department for Exiting the European Union if his department had been cut out of the loop, he said: "There is no way of getting around it. Yes. I mean the Secretary of State and I have resigned for reasons, and these are amongst the reasons. "The reality here is that leaving the European Union is a very difficult process. The establishment in this country doesn't want to leave the European Union." Mr Baker took the opportunity to welcome the "clever and determined" Dominic Raab to his new role as Brexit Secretary, and he cooled talk of a backbench challenge to Mrs May, urgin every member of parliamentto "pause and think about the delicacy of the political situation". The arch-Brexiteer added: "There can be no questions of letters going in, no questions of challenges to the Prime Minister, what we need is a change of policy and not challenging the Prime Minister. "If people think it's a good idea to get into a three-month leadership contest, followed by the necessary general to fix the numbers, when exit day is so close, then they really are on another planet. "It is time for everyone to simmer down, work out what they believe in, and to offer constructive solutions." Related Rishi Sunak Promises "New Framework" To Tackle Extremism As Political Division Hots Up By Zoe Crowther 01 Mar PoliticsHome Newsletters PoliticsHome provides the most comprehensive coverage of UK politics anywhere on the web, offering high quality original reporting and analysis: Subscribe Read the most recent article written by John Johnston - MP Warns That Online Hate Could Lead To More Real World Attacks On Parliamentarians


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Yes the rumors are true; the MotoringFile garage is hosting one of Randy Webb's last ever Pulley parties today. From 9am to 11pm Randy will be in the garage installing everything from 15% Pulleys to full Miltek exhausts and everything in between. And yes, that includes adding a certain 15% magic bullet on my own MCS. If all goes well I should have pics on the MotoringFile Flickr pool throughout the day.
[ MotoringFile Flickr Pool ] Flickr


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Year-end report 2021
Fourth quarter 2021 (Q4 2020)
- Order intake decreased 10 percent, totaling SEK 74 million (82)
- Sales increased 10 percent to SEK 130 million (118)
- Operating profit totaled SEK 30 million (22), corresponding to 23 percent (19) of revenue
- Adjusted operating profit totaled SEK 32 million (27)
- Earnings after tax totaled SEK 21 million (13)
- Earnings per share before and after dilution amounted to SEK 0.35 (0.26)
- Cash flow from operating activities totaled SEK 33 million (32)
Jan–Dec 2021 (Jan–Dec 2020)
- Order intake decreased 20 percent, totaling SEK 377 million (470)
- Sales decreased 3 percent to SEK 405 million (415)
- Operating profit totaled SEK 38 million (60), corresponding to 9 percent (15) of revenue
- Adjusted operating profit totaled SEK 60 million (65)
- Earnings after tax totaled SEK 20 million (33)
- Earnings per share before and after dilution amounted to SEK 0.37 (0.65)
- Cash flow from operating activities totaled SEK 11 million (53)
Events during the fourth quarter of 2021
- On October 15, 2021, Permascand announced that the company had signed a framework agreement with one of the largest global players in chloralkali and diaphragm technology. The value of the agreement is estimated at between SEK 30–50 million per year during the three-year contract period.
CEO comment: Continued strong profitability despite supply chain disruptions
The fourth quarter of 2021 is testament to the fact that we are on the right path in our continued journey of growth, in which we will continue to deliver profitable growth by capitalizing on rapidly growing markets being driven by megatrends in environment and sustainability.
During the quarter, we continued to be affected primarily by a volatile supply chain that affected customers' decision-making processes in the short term. We thus found many of our customers holding off on placing orders during the quarter. We still displayed strong total figures for the quarter. Sales increased 10 percent to SEK 130 million, and once again we achieved a robust gross profit of SEK 47 million, which corresponds to a gross margin of 36 percent. This is proof that the investments we made in automation has resulted in improved production processes. We delivered an adjusted operating profit of SEK 32 million during the quarter, compared with SEK 27 million in the year-earlier period. This, despite a larger cost base as a result of the investments we made for future growth.
We are experiencing a historically high level of activity, with several customer inquiries in all three of our business segments. The high level of activity is a prerequisite for a strong commercial order intake and sales in the future, which is originating from smaller project orders. To maximize performance and sustainability, Permascand's solutions are to a great degree tailored to the end customer through dialogue, testing and adaptation. There is no doubt that the underlying demand in the market remains high, given the significant interest from customers looking to initiate discussions and partnership agreements.
Our ambitions in green hydrogen – a sub-segment under Electrification & Renewables – are high. Our largest innovative effort, the construction of a full-scale technology and innovation center and investments in the company's research team, proceeded according to plan during the quarter. There are strong opportunities in the market for green hydrogen produced via electrolysis, a market in which Permascand has delivered electrodes for electrolysis for over 20 years.
The level of activity in Industrial Solutions remains healthy, and numerous interesting dialogues are in progress. This indicates a strong underlying demand driven by increased awareness of the climate gains that are generated by the use of dimensionally stable anodes. We have also been working intensely on a new type of high-efficiency coating technology that is planned to be put into operation in the second quarter of 2022. The higher efficiency leads to lower costs and a more sustainable production.
Water Treatment was relatively unchanged during the quarter. The pandemic continued to have a short short-term dampening effect on the shipping industry and the growth in the field. The need for systems that can efficiently purify ballast water remains, and we believe that market conditions beyond the pandemic remain unchanged.
Using a flexible approach, we have been highly successful in adapting our operational activities to the prevailing situation. In combination with improvements in automation and robotisation, we will continue to increase our efficiency in the various parts of our operation so that we will be ready when the market situation returns to normal. We look forward to the remainder of 2022, where we will be well positioned to capture additional market shares and strengthen our profitability to increase our lead over our competitors.
Peter Lundström, CEO
Report presentation
CEO Peter Lundström and CFO Linda Ekman will present the report in a conference call today 10 February at 10:30 CET. The presentation will be held in English and will be concluded with a Q&A session.
Link to the presentation: https://tv.streamfabriken.com/permascand-top-holding-q4-2021
Telephone numbers for the conference call:
US: +1 631 913 1422 (Pin: 27301922#)
Link to report
The report is attached to this announcement and can be found at: https://permascand.com/investors/financial-reports/


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High memory usage when opening the lock menu
Like the title says, when I click the lock icon at the left of the URL the menu appears bugged and firefox starts using all the RAM in the system until I kill the process. This does not happen on Safe Mode.
Isisombululo esikhethiwe
Found out that the "Refresh Firefox" button doesn't delete bookmarks and history and tried it. For now the problem appears solved. Thanks for the help.
Funda le mpendulo ngokuhambisana nalesi sihloko 👍 0All Replies (5)
It could be the work of one of your add-ons, or it could be Hardware Acceleration. How to disable Hardware Acceleration {web link}
Type about:addons<enter> in the address bar to open your Add-ons Manager. Hot key; <Control> (Mac=<Command>) <Shift> A)
In the Add-ons Manager, on the left, select Extensions. Disable a few add-ons, then Restart Firefox.
Some added toolbar and anti-virus add-ons are known to cause Firefox issues. Disable All Of them.
If the problem continues, disable some more (restarting FF). Continue until the problem is gone. After, you know what group is causing the issue. Re-enable the last group ONE AT A TIME (restarting FF) until the problem returns.
Once you think you found the problem, disable that and re-enable all the others, then restart again. Let us know who the suspect is, detective.
No. Disabled Hardware Acceleration and the problem continues. Also, I don't have any addons.
parodper said
This does not happen on Safe Mode.
Safe Mode is a troubleshooting mode that temporarily turns off hardware acceleration, resets some settings, and disables add-ons (extensions and themes). If the problem goes away, that tells us one thing. If it does not, that tells us something else.
Have you tried the default theme?
You can create a new profile as a quick test to see if your current profile is causing the problem.
See "Creating a profile":
If the new profile works then you can transfer files from a previously used profile to the new profile, but be cautious not to copy corrupted files to avoid carrying over problems.
Isisombululo Esikhethiwe
Found out that the "Refresh Firefox" button doesn't delete bookmarks and history and tried it. For now the problem appears solved. Thanks for the help.


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So East Hampton Village beach passes went on sale just a few days ago. So, how is it going? Um, it's sick. My best friend's sister's boyfriend's brother's girlfriend heard from this guy who knows this kid who's going with the girl who saw Ferris at 31 Flavors last night and he said they sold a crazy number of passes already. So, I guess it's pretty serious. According to the friend of Ferris, 2500 beach passes were gone after only two days of sales. In a normal year, that number would be closer to 200. So if you're looking forward to sunning in the sands of any of the village beaches, you better run to Village Town Hall (86 Main St., East Hampton) with your license, registration or check and get your permit. You can also try going on line by clicking here:
Meanwhile, the real estate market is expected to do very well in 2021, with mortgage rates that are hovering at historic lows and forecasted by experts to remain favorable throughout the year. One challenge to the housing industry especially here in the Hamptons, is the lack of homes available for sale today. Last week, the National Association of Realtors (NAR) released their Existing Home Sales Report, which shows that the inventory of homes for sale is currently at an all-time low. The report explains:
"Total housing inventory at the end of December totaled 1.07 million units, down 16.4% from November and down 23% from one year ago (1.39 million). Unsold inventory sits at an all-time low 1.9-month supply at the current sales pace, down from 2.3 months in November and down from the 3.0-month figure recorded in December 2019. NAR first began tracking the single-family home supply in 1982."
What Does This Mean for You?
If You're a Buyer:
Be patient during your home search. It may take time to find a home you love. Once you do, however, be ready to move forward quickly. Get pre-approved for a mortgage, be prepared to make a competitive offer from the start, and know that a shortage in inventory could mean you'll enter a bidding war. Calculate just how far you're willing to go to secure a home and lean on your real estate professional as an expert guide along the way. The good news is, more inventory is likely headed to the market soon, Lawrence Yun, Chief Economist at NAR, notes:
"To their credit, homebuilders and construction companies have increased efforts to build, with housing starts hitting an annual rate of near 1.7 million in December, with more focus on single-family homes…However, it will take vigorous new home construction in 2021 and in 2022 to adequately furnish the market to properly meet the demand."
If You're a Seller:
Realize that, in some ways, you're in the driver's seat. When there's a shortage of an item at the same time there's a strong demand for it, the seller is in a good position to negotiate the best possible terms. Whether it's the price, moving date, possible repairs, or anything else, you'll be able to request more from a potential purchaser at a time like this – especially if you have multiple interested buyers. Don't be unreasonable, but understand you probably have the upper hand.


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The fact is most us feel awkward about having our pictures taken. Where do I put my hands, where do I look, how should I stand? I don't know what to do! These are things that I often hear from my couples during their portrait session (Funny, but I, too, feel pretty strange when someone takes a picture of me!) And you know what, that's alright. We're not used to being in front of a camera for hours at a time. Sure, an occasional good-looking selfie here and there is fun, but what about your wedding pictures where you absolutely have to look great regardless of weather conditions and strict timelines?
As in any situation, I have tried-and-true tricks in my tool kit to get you looking your best, especially on your wedding day. One of the basic tricks to looking great in any pictures is giving your body a shape. This can be achieved by slightly lifting one of your shoulders, by putting one of your legs forward, or allowing all of your weight to fall on only one leg with a slight bend in the other. The former is especially true when taking pictures with your back turned to a photographer. It gives a flattering "S" curve to your whole shape and adds instant elegance to the look. Bringing one leg forward is great when taking front full-length portraits. The same is true for grooms. Bring your weight to one foot and slightly bend your other leg in knees. Put your hands in pockets and DANG! You look like a pro.
Every couple's dynamic is different and I love when the pictures show this off and it comes out naturally. That is why you will see me gently modifying your natural stance as opposed to full on directing. The greatest thing for me is to see your personality shine through. Allow yourself to live in the moment, after all it is your wedding day. Bask in the happiness and excitement of your day and try to forget about the camera. I strive to capture beautiful wedding imagery full of intimacy and raw emotions. Therefore, I opt to guide my couples while staying true to their unique nuances. There are endless ways to capture excitement, energy and joy that comes with the wedding day, and my role is to capture them ever so truthfully. Even when you pose.
As seen on WedLuxe
Venue: Liberty Grand
Florist: Forget Me Not Flowers
Gown: Inbal Dror


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The mid-face of this patient and her upper eyelids were her areas of concern. Dr. Weintraub performed a mid-face suspension to remove her jowls and he gently repositioned her cheeks to create a more youthful appearance. In addition, he removed the skin and excess fat of her upper eyelids with unseen incisions to youthen her eye area to produce a natural – not a "deer in the headlights" – result.
Click here to set up your consultation with Dr. Weintraub


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Hover over the slide show to pause it.
orTel: 01566 451299
Or visit us on Facebook at www.facebook.com/DartmoorViewDogRescue
This is Fred the Shih-tzu x Cairn who will be 3 in July. His elderly owner died and Fred found himself in kennels and I think that is why he was in such a state when he came in and would bite anything that went near him. Had him in my bedroom so I could talk to him and reassure him and well, he is a totally different dog now. Playful, happy and a total nutcase. He has been totally spoilt and let do what he wants in his old home so whoever takes him on has some work to do, but will have a fun loving boy who has us in stitches. His problem is he has what is called "queen Ann legs" so I cannot say if they will play him up later. At the moment he is jumping on everything. He is good with other dogs although over the top and I would not put him with children as he still mouths. He is neutered and vaccinated. If you think you are the right home for Fred please message me.
UPDATE Well Fred is back. Got on with other dog, and loved his walks with him, but kept chasing and nipping the little girl. A home without children and someone who is used to little dogs who like their own way, but have to be taught otherwise.
All of the dogs that come through our doors go through a period of assessment and medical treatment as required, this will enable us to discuss with you the current needs of the dog.
By default the dog will be:
For guidance only:
We advise you spend time with the dog. Please be aware that it's personality will change over time as they/you interact.
You will be asked to complete a pre adoption/home check form.
When we have received this we will make contact with you and arrange a home visit, where we will verify your home check paperwork.
You will then be asked to complete the adoption paper work and you will need to sign the declaration to say that you accept the terms and conditions.
If at any stage in the adoption process, we feel that the situation is not right for our dog, you may be turned down. We don't have regimented rules on what homes are suitable.
If you decide to adopt one of our dogs we ask for an adoption fee of £175 - £200 (to cover some of our costs), this depends on the age and breed of the dog.
Sometimes we have older dogs looking for homes which we lovingly call our 'doggy pensioners' and for these dogs we ask for a reasonable donation. Older dogs make wonderful pets.


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Stop abusing child refugees (says illegal immigrant from Darkest Peru)
Paddington creator and other authors and actors send letter to Downing Street
Stop abusing child refugees (says illegal immigrant from Darkest Peru)
Show all 2They are stern words that doubtless come accompanied by a trademark hard stare from Britain's most famous illegal immigrant.
Some 51 years ago, Paddington Bear arrived on these shores after surviving on marmalade as a stowaway from Darkest Peru and was given sanctuary at 32 Windsor Gardens by Mr and Mrs Brown, two paragons of traditional British hospitality towards foreign minors in need of a decent home.
Now the stray bear, who came to Britain accompanied with a note from his ailing aunt asking that he be looked after, is spearheading a campaign – along with more than 60 children's authors and illustrators – to highlight the Government's continued arrest and detention of hundreds of child asylum-seekers in prison-like conditions.
Michael Bond, the creator of the much-loved blow-in from South America, has harnessed Paddington's experience to contrast his good fortune in finding a home in Windsor Gardens – a thriving, inclusive community in west London, with the exception of the Browns' grumpy neighbour, Mr Curry – with the fate of up to 2,000 children who are held each year in detention centres by the UK Border Agency (UKBA).
The poet laureate, Carol Ann Duffy, Quentin Blake and Philip Pullman, along with the actors Emma Thompson and Colin Firth, are among those who have added their signatures to a letter to the Prime Minister condemning the detention policy and supporting calls by leading doctors for its immediate cessation.
The letter is accompanied by a special message written in the words of Paddington Bear. It said: "Whenever I hear about children from foreign countries being put into detention centres, I think how lucky I am to be living at number 32 Windsor Gardens with such nice people as Mr and Mrs Brown.
"Mrs Bird, who looks after the Browns, says if she had her way she would set the children free and lock up a few politicians in their place to see how they liked it!"
Although the UKBA itself has admitted that there is no evidence that families with young children abscond in significant numbers, the agency arrests and detains between 1,000 and 2,000 asylum-seeking children every year.
David Wood, UKBA director of criminality and detention, told a parliamentary committee in September: "Whilst issues are raised about absconding, that is not our biggest issue. It does happen but it is not terribly easy for a family unit to abscond."
The policy of keeping hundreds of children in secure conditions at immigration removal centres is the subject of increasing concern among health professionals and campaigning groups amid evidence that minors are suffering long-term harm.
Two Anglican priests, one of them dressed as Father Christmas, were this month barred from entering the Yarl's Wood detention centre in Bedfordshire to deliver £300-worth of presents to children which had been donated by several London churches.
The Royal Colleges of Paediatrics and Child Health, alongside two other professional bodies – General Practitioners and Psychiatrists, and the Faculty of Public Health – last week issued a joint statement condemning the Government's detention policy and calling for it to end "without delay".
In October, NHS paediatricians and psychologists reported in the international peer-reviewed journal, Child Abuse & Neglect, that children locked up at Yarl's Wood were "clearly vulnerable, marginalised, and at risk of mental and physical harm as a result of state-sanctioned neglect".
The doctors recorded children's "sexualised behaviour" and older children's tendency to wet their beds and soil themselves, citing the "increased fear due to being suddenly placed in a facility resembling a prison" and the "abrupt loss of home, school, friends and all that was familiar to them".
Nearly 100 MPs have also signed a parliamentary motion put forward by the Labour MP Chris Mullin urging the Government to stop detaining children.
The petition to Mr Brown reads: "As writers and illustrators of books for children, we urge you to stop detaining children whose families have sought asylum in the UK. These children have already had their worlds torn apart and witnessed their parents in turmoil and in stress. No wonder that paediatricians and psychologists report that child detainees are confused, fearful, unable to sleep, suffer headaches, tummy pains and weight loss and exhibit severe emotional and behavioural problems."
The document adds: "The UK Border Agency says that 'treating children with care and compassion is a priority', but it continues with the policy of child detention which has been shown to harm children. The Government must end child detention, now."
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Exploring Chinese History is a site all about the history of China, from ancient times to present day. It is broken down into five eras and includes information about Chinese culture, politics, and geographical regions. You can also view the website's source list for further reading and learning! Here is an overview of each section:
The historical content of the site is divided into five sections: prehistory to 1279, 1279 to 1912, 1912 to 1949, 1949 to 1976, and 1976 to present. Each section is more thoroughly broken down into specific periods with comprehensive information on traditions, scholars, dynasties, wars, trading, and more! Study notes and outlines are available for students and interested learners.
Information about Chinese literature, language, philosophy, and religion can be found on the culture page. If you want to learn about Daoism, the Qin Mausoleum and Terracotta Army, or modern Chinese writers, start by visiting the culture section! There is also an image gallery dedicated to the art of calligraphy. For more images, visit the supplemental website The Art and Images of China to see photographs of architecture, history, people, and more.
The politics section discusses government structure, important figures, rebellions, important documents, conflicts, and human rights issues. Most of the content focuses on 19th and 20th century politics and international relations. The politics sections pairs well with the modern era history content and covers events like the Opium Wars, World War I, and World War II.
Other East Asian Regions are described on the site, including Hong Kong, Japan, Korea, Mongolia, and Taiwan. You can explore each region in detail to learn geographic information and facts about culture, religion, demographics, economics, and politics.
The site contains special guides about Chinese New Year and Chinese Characters that can be found on the features page. If you are interested in visiting other ibiblio sites, the Chinese tag in the Language & Culture section has many resources including music, ancient texts, and cultural exploration. If you enjoyed Exploring Chinese History, make sure to check out the tag!


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A book by any other name doesn't necessarily smell as sweet. Or sell as well. Or sell as poorly. How much does a title matter on a blog post? On a movie? With that being so, I'm interested in the impact of the title shown here, on Bob Sutton's extremely successful latest book. It's an excellent book, by a well-liked and respected Stanford business school professor who's written a number of important business books. It's had a lot of impact too, as in buzz, reviews, commentary; and lots of published praise. It won a Quill Award for the best business book of 2007.
But the title puts me in a bind. Think about spiders, Web crawlers, quirky little programs that run around the Web scanning for words in the html code, and blacklisting sites that have those words. This is how the spam filter functions. What if you want to email a friend recommending this book. The spam filter says no.
There is no due process for Internet blacklists. Google "Internet blacklist" and you'll find 17,600 items, most of them caught in the net and flailing desperately to get out. Get blacklisted on AOL, for example, and you're cut off for a long time. You can't email anybody with an AOL address. Try doing business like that. No due process means in extreme cases it's one bad word combined with a word filter and, context be damned, you're out in the cold.
For a moment let's give the spam filters and Web crawlers and the like a break. Do you think they enjoy spending all day every day scanning for so-called "bad" words? Thankless job, but there is so much junk to be filtered … do we have to ask them to actually read and discriminate in context, now, so we can talk about a great book with a trigger title? We're dealing with code here, and algorithms, and word screening. Don't ask those program routines to evaluate context.
Earlier this evening I posted Do You Want to Fire Your Client on Up and Running. It's about a common problem. Guy Kawasaki posted Is Your Client A Certified Orifice, which links to the Client from Hell Exam and Bob Sutton's post on his blog about how to fire a bad client. I came up with my own story on dealing with bad clients; but that's not the point of this post.
I wrote around that trigger word in the title. Guy called them "orifices." As I'm doing with this post, I showed a graphic of the title, and I hope that keeps me safe.
Bob Sutton, meanwhile, has a two-part post on Huffington Post that is both hilarious and chilling. He titles it Title Tales: Weird Censorship. And it makes me feel small for not just using the title, like the Huffington Post does, and The New Yorker, and Time magazine, and several others. He has a list of 13 responses, from "we like the book but are afraid to say anything about it" to "repeat the word over and over again because listeners would enjoy it." Unfortunately, his list makes me fill silly for making a point of it. His post in Huffington isn't the only one around; he's had several thoughtful posts on this issue, one from Publisher's Weekly that goes into court ramifications. It's a real issue.
It bothers me, however, to call euphemisms for specific screen words censorship. Fear of spam-filter and word screening problems is not the same as wanting to keep thoughts or ideas or information away from people. I'm not really saving you from the word a**hole by putting asterisks in, and we both know it. Spam filters have a real problem to solve, and word screening helps.
Still, this is one of my longer posts, and it's related to that other post. So it obviously bothers me. Fear of blacklists. And I can't help but wonder, is the attention-grabbing title good for sales? Would the book have been better off with a different title? I don't know. I'm just asking.
Somewhere in this discussion is the question of whether or not the language is worth the drawbacks. There is no asterisk-filled public dialog or bleeped out video as profane as fourth grade boys on the school playground. So why bother? If you need authentic dialog for your screenplay, then I get it, because that's the way some people talk. But in the printed word, and especially the filtered and word-screened words, using another word instead is not such a bad thing. I think.
Brilliant P.S.: TypePad's antispam filter has flagged that comment of mine as potential spam.
And I didn't even say anything!
: )
Tim, this reminds me of a related issue we ran into yesterday, less profane but no less problematic.
Chelle recommended a new video sharing site she called "vee-mee-oh." We were in a meeting, so no spelling was involved. I entered my best guess — vemio.com — into my browser and got a site promoting the "micro mini thong bikini." Add that one to Great Moments in Meeting History.
It turns out the video site is http://www.vimeo.com, though it could just as easily have been VmeO or veemeeoh or half a dozen other variants.
In the quest for company and product names that make unique keywords online, businesses are increasingly failing on the basic requirement of making their domains verbally communicable.
In fact, misbehavior here has become almost hip, with companies embracing willful obfuscation in names like XLR8R.com and mixxstr. (And does anyone remember, without Googling, where the dots are supposed to go in Del.icio.us?)
As a marketer, I'm certainly aware of the difficulty of finding unique space to stake out online — and of promoting a plain-English-titled product like, in our case, "Business Plan Pro" that faces a lot of keyword competition. But I don't think ambiguous nonsense words or aggressive misspellings offer a reasonable solution.


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(Moscow) Russia has imposed sanctions on nine Canadians in response to Canadian restrictions on Russian officials accused of playing a role in the imprisonment of dissident Alexei Navalny.
The Russian Foreign Ministry has announced that several senior Canadian officials will be denied entry, including Minister of Justice and Attorney General David Lamty, Police Commissioner Brenda Lockey and Canadian Corrections Commissioner Ann Kelly.
Russia's sanctions also target Intergovernmental Affairs Minister Dominique LeBlanc, Prime Minister Marcy Sorex, Deputy Commissioner of the Royal Canadian Mounted Police Brian Brennan, and Deputy Chief of Defense Staff Mike Rouleau.
Moscow imposed similar sanctions on European and American officials for the same reason.
Alexei Navalny, the most vocal opponent of Vladimir Putin's presidency, was arrested in January after returning from Germany, where he had spent five months recovering from a poisoning he attributed to the Kremlin.
In February, Navalny was sentenced to two and a half months in prison for violating his suspended sentence while in Germany. This punishment came against the backdrop of accusations of embezzlement in 2014 for political reasons, according to the accused.
Russia has rejected the blatant criticism of the United States and the European Union over the imprisonment of Mr. Navalny and the repressive measures taken by Moscow against his opponents.
The tensions arising from the Navalny affair have exacerbated an already strained relationship between Russia and the West, which has been marred by the annexation of Crimea, accusations of election interference, and cyber attacks.
Foreign Ministry spokeswoman Maria Zakharova said in a statement that Russia is open to "developing relations on the basis of mutual respect, focusing on cooperation on issues such as the Arctic, inter-regional relations and economic issues where interests converge."
"Subtly charming problem solver. Extreme tv enthusiast. Web scholar. Evil beer expert. Music nerd. Food junkie."


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Wilson Creek Area Trail Improvement Timeline
Highlights of our work in Wilson Creek and the Grandfather District of Pisgah National Forest
The Alliance has been advocating for trails in Pisgah since our inception, and starting in 2020, the Mortimer Trails Project has become a key piece in our work in the forest.
The plans all of these projects are to provide better functioning trails, with a strong focus on environmental sustainability and user needs.
The chapter has been leveraging resources to make all of this happen, through Forest Service collaboration, grants, and partnerships with other organizations.
Listed below are just some of the many highlights of our work in Pisgah National Forest.
Trail Segment or Event
Work Completed
What to expect
The future is strong for our relationship with USFS and Wilson Creek will continue to get the love it deserves for years to come.
These projected dates are likely to change, and this page will continue to be updated.


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Due to the importance of dental health in an individual's life, one is advised to visit a dental clinic at one point for dental checkup. Visiting a dentist is a very good decision that you can ever make because it will help you to monitor your dental health and be able get the treatment on time if there is any problem with your teeth. Make sure that that your oral health is in the hands of a profession because your dental and oral health depend on it. When it comes to health matters, it is very important to ensure that you do not just visit any dentist but be sure that your dental and general dental health is in the hands of a professional.
You must use any available avenue for you to ensure that you get all the information about the dentists around you in order to ensure that you get the right dentist. Making enough inquiry about the dentists in your area will help you to decide which dentist you can work with. A good cosmetic dentist weybridge should be able to take care of all your dental and general oral health issues and guide you accordingly as far as your oral health is concerned. A qualified and experienced dentist should have necessary equipment for your dental and general oral health checkup and treatment.
The other thing that you need to do is to make sure that you work with a dentist that is within your reach whenever you need them. This kind of situation means that you will end up suffering in one way or the other if you choose to work with a dentist who does not operate in your neighborhood. The nearer the dentist the better for you because it means that you will be able to see your dentist whenever need arises.
The next step after getting a good and qualified dentist is the cost aspect as many dentists might decide to charge for their services more than others. The availability of many dentists in your area is an added advantage for you because it means that you have room to bargain for quality yet affordable services. Get the services of the best dentist in weybridge you can find in your area but make sure you can afford the charges in order to avoid problems.
This information will help you to be psychologically prepared whenever you require to go through any dental health process. Having prior knowledge about what you are expected to go through will help you to prepare in advance and make the necessary arrangement before you undergo the dental health procedure. A qualified and experienced dentist should be careful enough when undertaking any dental or general oral procedure on you.
Gather more facts by clicking here: http://www.dictionary.com/browse/dentist


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Agitation kit – three
June 26, 2020
Agitation set of all necessary components and accessories for three standard GL45 laboratory bottles. Maximum twelve additional agitators can be ordered and easily connected in series to the existing agitation kit – three.
The kit includes:
3 multifunctional brushless DC motors
1 motor controller
3 long motor signal cables
3 power couplings
3 mixing rods and plastic caps
1 24V power adapter
Article number 14-0101-03


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The Square Root of Summer
Harriet Reuter Hapgood
Age 12 +Synopsis
My heart is a kaleidoscope, and when we kiss it makes my world unravel . . .
Last summer, Gottie's life fell apart. Her beloved grandfather Grey died and Jason, the boy to whom she lost her heart wouldn't even hold her hand at the funeral. This summer, still reeling from twin heartbreaks, Gottie is lost and alone and burying herself in equations. Until, after five years absence, Thomas comes home: former boy next door. Former best friend. Former everything. And as life turns upside down again she starts to experience strange blips in time - back to last summer, back to what she should have seen then . . .
During one long, hazy summer, Gottie navigates grief, world-stopping kisses and rips in the space-time continuum, as she tries to reconcile her first heartbreak with her last.
The Square Root of Summer is an astounding and moving debut from Harriet Reuter Hapgood.
The must-read of the summer... a new twist on coming-of-age, told with vibrance, intelligence, and beautyBuzzFeed
a buzzy debutMarie Claire
Love, loss and heartbreak told in a wholly authentic teenage voiceThe Bookseller


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The Black Lives Matter (BLM) movement continues to be a thorn in the side of Democratic politicians. BLM activists recently managed to secure a meeting with presidential candidate Hillary Clinton, where they asked her some pointed questions about her past policy decisions.
The group was initially barred from entering a community forum on drug abuse being hosted by Clinton at Keene Middle School in New Hampshire. The event was sealed by the former first lady's security. Clinton later met with BLM activists in an overflow room.
The group – affiliated with Black Lives Matter organizations in the Boston area — told reporters afterwards that they asked Clinton about her family's history with the war on drugs, both at home and abroad. Specifically, activist Daunasia Yancey (who has been described as "the new face of Boston's civil rights movement" by Boston Magazine) told reporters they asked Clinton about her family's history with the war on drugs both at home and abroad and "how she felt about her involvement in that violence that has been perpetuated, especially against communities of color and against Black folks."
"Can you give at least one tangible example of how you expect to reverse the health and human services disaster you orchestrated in impoverished, urban, non-white communities through the domestic [war on drugs] policy you've championed as FLOTUS and senator?" BLM activists asked.
The meeting with Clinton lasted about 15 minutes and included some contested questioning. Clinton also offered advice to BLM activists.
Black Lives Matters activists have been a vocal presence at campaign events hosted by Democratic politicians. They stormed the stage at the Netroots Nation conference interrupting speeches by Democratic candidates former Gov. Martin O'Malley and Sen. Bernie Sanders. Activists who claimed to be involved with the BLM movement also stormed the stage and prevented Sanders from giving a speech at a campaign event in Seattle, Wash., drawing criticism from some Black liberals.
However, BLM protestors' actions seem to be working. Sanders recently hired Symone Sanders, a Black social justice activist, to be his press secretary. He also released a racial justice manifesto outlining how he planned to address some of the issues BLM activists have raised, such as demilitarizing the police and ending the war on drugs.
"Sandra Bland, Michael Brown, Rekia Boyd, Eric Garner, Walter Scott, Freddie Gray, Tamir Rice, Samuel DuBose. We know their names. Each of them died unarmed at the hands of police officers or in police custody," said Sanders on his campaign site. "We should not fool ourselves into thinking that this violence only affects those whose names have appeared on TV or in the newspaper. African Americans are twice as likely to be arrested and almost four times as likely to experience the use of force during encounters with the police."
For Clinton's part, she recently gave a speech calling for an end to mass incarceration, noting that a large percentage of the more than two million Americans currently in prison are low-level offenders.


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@nellyja said in Growling at dogs during walk:
Read best tips for dog training is to think growing dogs
best tips? Not even close. Tie a collar and leash to pup while it eats? Beyond that, nonsense. I wonder how many sites you go to in order to spam with that site?


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Reading pilot James D'Silva and TV presenter Denise Van Outen became the first two people to pose for a souvenir cockpit picture at the launch of British Airways' (BA) new photo app.
Mr D'Silva is one of BA's 4,000 pilots who now have the 'View From The Flight Deck' app installed on their iPads and are offering to take photos of passengers who visit the cockpit before take-off or after landing.
The app automatically sends all snaps, which include graphics displaying flight facts, to passengers who want a memento of their trip.
After getting snapped Denise said: "I love travelling with my family and want to remember all those precious moments with Betsy as she grows up.
"I think this a great new way to create another fun holiday memory, and it's a bit different to the photos you'd normally bring back from a trip.
"As souvenirs go it beats a fridge magnet by a mile."
BA is now encouraging all passengers to pay a visit to the cockpit and pose for a picture.
Captain Charlie Maunder, head of flight operations, said: "As pilots we love flying and naturally want to share that with everyone, so we all enjoy welcoming customers up to the cockpit whenever possible.
"We're always looking for new ways to make sure everyone has a memorable flight every time they fly and our new souvenir photo flight app is a great way to help us do just that."
The app was developed by one of British Airways' pilots and is another initiative in the airline's bespoke 'Beyond the Flight Deck' programme, which is designed to help its flight crew best serve customers before, during and after their flight


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LEGENDARY crooner Tony Bennett has travelled all over the world to perform but for him a visit to Scotland is always special.
Whether it's an official gift from the city of Glasgow or comical trouble with the local accent, the singer could talk all day about his visits.
He is back later this month, performing at the Glasgow Royal Concert Hall, where he is expecting the usual audience singalong, not something he experiences in the south of England.
He said: "I love Scotland. I've noticed the audiences become warmer as I head further north.
"London is highly sophisticated and it's a wonderful experience but as soon as I go up to places like Manchester and Glasgow, the friendlier it gets – it's thrilling.
"They sing along to my songs with me in unison, which I absolutely love, whereas I'd say the London crowd is a bit more restrained."
He still treasures a gift from the Lord Provost of Glasgow, given to him more than 30 years ago.
He said: "The first time I went to Scotland, the Provost gave me an oil paint set. He found out I was interested in painting and wanted to encourage me. I couldn't believe it. I have it to this day and still work with it."
The singer's frequent trips have also meant that he is now used to even the strongest Scottish brogue but it wasn't always the case.
"In the early days it seemed like a foreign language," Tony smiled.
"I remember asking a lady the time in Glasgow and she said 'Nine' – to me, it sounded like German for 'No'.
"I'm just so happy I'm coming back again and I'm looking forward to it. I've been touring Britain for 60 years now and the Brits have always been beautiful to me. I've got a lot of good friends there."
Tony, who performs in Glasgow on June 25, has won 15 Grammys and sold more than 50million albums during his career.
He is now a very wealthy man and could afford to take it easy but he continues to record and tour. He can't wait to get on stage again and points to the Queen as an example of why age should never be a barrier.
"I love to perform and make people feel good, I'd never retire," he said. "Why be negative about getting older? Look at your Queen. She's unbelievable for her age and I love her. I've met her at quite a few Royal command performances and I've always thought she was an incredible asset to your country.
"I watched the Jubilee coverage in New York and I was glued to the TV.
"It was phenomenal. Even when it rains, you folks carry on."
Remarkably, the US singer has managed to move with the times, while still continuing to satisfy his long-time fans.
On last year's hit album Duets II, he performed with some of the world's top contemporary singers like Lady Gaga and the late Amy Winehouse. The album debuted at No1 in the US, which was a first for Tony and also made him the oldest living artist to do it.
Tony and Amy's jazz song Body and Soul was on the album and was released as a single. It turned out to be the last recording the tragic singer ever made.
"I loved working with Amy. She was such an honest singer and when she was singing, she really meant it. There was amazing depth to her voice."
Her premature death last July came as a terrible shock to Tony, who was something of a mentor to Amy.
"It was tragic what happened. I wanted her to be with me when I celebrated my 85th birthday at the Palladium.
"She should have been around a long time. She was as good as Billie Holiday or Ella Fitzgerald.
"From Elvis Presley on, I kept listening to all younger performers and was always saying, 'Who's got it?' And Amy was one who had it. It was a terrible experience when my son called me up and told me she had just died. It was a complete shock."They first met following one of his Royal Albert Hall concerts in 2009. He said: "Amy and her father popped into my dressing room and we hit it off straight away. She said she had always been a fan of mine, which was so nice.
"We kept in touch and I suggested she appear on my Duets II album."
After her death, he led moving tributes to her at last year's MTV Video and Music Awards and, as he talks about her, it's obvious he still feels a sense of loss.
"She put so much care into our song and I respected her for that."
Did he give Amy any advice about how to handle fame and its pitfalls, given his own, well-documented battles with cocaine in the 70s?
"I was so busy at the time and I regret not saying anything," he said.
"I was going to tell her to slow down and tell her to take care of herself because she was such an important singer but I never got a chance to do it.
"I'm still in touch with Mitch (Amy's dad). I was on stage with him when he received her Grammy award. The work he's doing to help young addicts is wonderful."
Amy was not the only artist to be in awe of Tony. He recalls even Lady Gaga relinquished control in their over-the-top version of The Lady Is A Tramp.
"I didn't know what to expect," he said. "She's such a big media superstar, I figured she would say, 'This is how I'd like to do it', but she looked me in the eye and said 'Anything you want me to do, I'll do.' I loved that. She's dynamite."
The singer, who spoke exclusively to the Record before jetting off for a break in Italy prior to his UK tour, has the energy levels of a man half his age.
A contemporary of singers like Frank Sinatra, during his heyday in the 50s he enjoyed huge success with best-selling albums like Basie Swings, Bennett Sings, and his signature tune I Left My Heart In San Francisco. But after the rock era took off, his classic jazz style was suddenly unfashionable and he was left without a manager or recording contract. He was also struggling with debt, a drug problem and his marriage was failing.
But he never lost hope. He said: "I'm a Leo so I'm always an optimist. Life has ups and downs and you have to accept that. When things do go down, I will just go, 'This too will pass.' Everything comes back – sometimes you have to fight for it but you always get it back."
• Tony Bennett plays Glasgow Royal Concert Hall on June 25.


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1.New and high quality
2.Energy-saving and environmentally friendly, high brightness
3.Low heat generating, no UV or IR light radiation
4.Seismic, impact resistance, non-thermal radiation, safe and stable, reliable
5.Ultra bright LED light
6.Portable, easy to install on a bike or used as camping, hiking light source
7.Adjustable headstrap
8.keep lamp from bouncing
9.Ultra bright LED light
10.High intensity LED
11.5 LED headlamp is new and never used. It is a LED light bulb with a long lifespan.Very low heat generating, besides saving light power. No IR or UV light radiation.
1.Light source: 5LED
2.Material: plastic
3.battery: 3 X AAA batteries(not included)
4.LED bulb lifespan: 100,000 hrs
5. Light Color: white
6. Dimensions: 2.44 x 2.76 x 1.57in/6.2 x 7 x 4cm(L X W X H)
7. Weight: 1.52 oz/43 g
Package include:
1 x 5 LED headlamp
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The Association Board normally meets monthly at different Board members' homes. All residents and owners are invited to attend any Board meeting. All Board meetings have an agenda item for "Homeowners Forum" for members to speak to the board on any topic.
Please contact email@example.com if you plan to attend and/or have a special topic you would like to place on the agenda. All meetings begin at 7PM unless otherwise noted.
The Association has an annual membership meeting in early-mid May of each year. Notice and agenda for the meeting are provided in the annual newsletter which is sent out in April. The meeting is required by the Bylaws. A quorum of 25% of owners is required for the meeting to be official. If an owner is unable to attend the meeting, then the Board recommends that they submit a proxy for their vote to another member of the association who may attend and vote for them. A copy of a proxy is attached.
The Association hosts a variety of events each year. If you are interested in learning more or volunteering to help organize a HOA sponsored event, please contact us to learn more.
- Spring Clean Up
- Summer Party
- Board Appreciation Dinner