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Emerging Disease-Modifying Therapies in Cystic Fibrosis Author's Note: REPORT FROM NACFC 2017 Editor's Note: Dr. Clancy attended this year's NACFC and has provided this report. Many of the emerging disease-modifying therapy presentations at the most recent NACFC (North American Cystic Fibrosis Conference) — held November 2017 in Indianapolis — focused on addressing the F505del CFTR defect. This mutation, heterozygous in the large majority of persons with CF, has proved particularly difficult to correct, with defects in folding, opening, and stability at the cell membrane. Taylor-Cousar and et al reported the results (since published in NEJM)1 of a large phase 3 study of tezacaftor/ivacaftor in patients > 12 years and homozygous for F508del. After 24 weeks, tezacaftor/ivacaftor increased FEV1 percent predicted by 4% over placebo, and lowered the rate of pulmonary exacerbation by 35%. The incidence of adverse events was similar in both the treatment and placebo groups, with serious adverse events less frequent with tezacaftor/ivacaftor. Rowe et al reported the results (also published in NEJM)2 of a phase 3 study of tezacaftor/ivacaftor vs ivacaftor alone vs placebo in CF patients with one copy of F508del and a second mutation predicted to have some residual function. Improvement in the absolute FEV1 percent predicted was 6.8% for tezacaftor/ivacaftor and 4.7% for ivacaftor alone (compared with placebo), with adverse events similar across the intervention groups. In addition, scores on the respiratory domain of the Cystic Fibrosis Questionnaire-Revised were also significantly increased in the tezacaftor/ivacaftor and ivacaftor groups compared with placebo. Clinical trials continue on "next generation correctors" — CFTR modulators added to tezacaftor/ivacaftor. Early evidence has shown efficacy in both F508del/F508del and F508del/minimal CFTR function genotypes. Addressing F508del from another direction were reports on the phase 1 open label, proof of concept studies of QR-010, a first-in-class RNA-based oligonucleotide designed to target the mRNA in patients with the F508del mutation. This inhaled therapy seeks, in essence, to introduce a short stabilized RNA template that instructs F508DEL CFTR airway cells to produce normal CFTR. Results in patients homozygous for F508del showed early evidence of QR-010 tolerance and potentially restored CFTR activity. References:
Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Drugs that restore CFTR function are termed CFTR modulators, and currently approved CFTR modulators include the potentiator ivacaftor and the combination F508del corrector lumacaftor + ivacaftor. Prior randomized, placebo controlled trials have demonstrated benefits of these therapies in patients with gating and conductance mutations (ivacaftor) and patients with two copies of the common F508del mutation (lumacaftor combined with ivacacftor). In this issue, Dr. John P. Clancy from the Cincinnati Children's Hospital Medical Center examines recent research regarding CFTR modulation, including:
After participating in this activity, the participant will demonstrate the ability to:
The data in the articles summarized in this issue teach us quite a bit about the clinical use of CFTR modulators, including long term effects in different groups, activity in younger patients, limitations to modulator use based on genotype, relationships between sweat chloride and a clinically relevant biomarker used regularly in care (lung function), and a novel mechanism that may contribute to CF lung disease and the rapid benefits observed with CFTR modulation. Two of the studies address questions of long-term experience with CFTR modulation, including the impact of chronic ivacaftor treatment in patients with the G551D mutation (Sawacki et al), and the impact of chronic lumacaftor/ivacaftor treatment in patients with two copies of the F508del mutation (Konstan et al). Important similarities and differences in these two articles impact their interpretation and clinical application. First, both examined data from open label extension studies that followed definitive placebo-controlled trials of ivacaftor (in patients with G551D mutations) and lumacaftor/ivacaftor (in patients with F508del/F508del mutations), respectively. They also compared data from each study with historical controls from the US Cystic Fibrosis Patient Registry (CFFPR), attempting to match each modulator-treated subject with several CFFPR subjects controlled for age, sex, chronic therapies, etc. It is important to note that this type of analysis can potentially introduce bias, as the data from the subjects within the open label extension modulator trials were part of a research dataset. Participation in research may influence patient motivations or select for subjects more capable of adhering to therapies. With this in mind, important observations were similar across the two groups, despite different levels of acute modulator efficacy. Specifically, both ivacaftor treatment in patients with G551D and lumacaftor/ivacaftor treatment in patients with F508del/F508del reduced the decline in lung function over time compared with their respective control groups. What was remarkable was the similarity in this effect, which ranged from 40%-50% across both drugs and both study populations. These results provide data supporting the notion that CFTR modulators can indeed modify CF lung disease. The term "CF disease modification" has recently been highlighted in connection with the development of CFTR modulators. This term (when applied to new therapies) implies that the trajectory of CF disease has been fundamentally changed. While disease modification is most directly demonstrated when describing the impact of therapies on loss of lung function over time (change in the rate of FEV1 decline), it can also be demonstrated by other effects such as reduced mortality. This type of analysis is beneficial when discussing the use of CFTR modulators with patients. Although acute effects on lung function and weight may be modest (particularly for patients with F508del/F508del starting lumacaftor/ivacaftor), data is emerging that the long-term benefits of lung function stability are significant. This ultimately may have a much greater impact on outcomes and survival and therefore is an important consideration with modulator therapy. Results from the manuscript by Rowe et al demonstrated some of the limitations in extending CFTR modulators into new populations. Specifically, CF patients with one copy of F508del CFTR and moderate lung disease were treated for two months with lumacaftor/ivacaftor and compared with placebo. No benefits were observed as measured by FEV1 percent predicted, but there was clear evidence of drug bioactivity (11 mMol/L eduction in sweat chloride) and improvements in pulmonary symptoms. The results do raise the question of whether there would be some clinical benefits (eg, perhaps such as those described above) if F508del CFTR heterozygous subjects received prolonged lumacaftor/ivacaftor therapy. The study also highlights the need for sensitive disease biomarkers that would predict disease modification. Some of these novel biomarkers were evaluated in the article by Milla et al, which summarized results of an open label study of lumacaftor/ivacaftor in young children (aged 6-11 years) with CF and preserved lung function. It was reassuring to find that the drug was well tolerated in this younger population, particularly since respiratory symptoms are not infrequently reported on initiation of therapy in older patients. Despite the study's open label nature, the impact of treatment on sweat chloride and the lung clearance index were remarkable and provide support for the use of CFTR modulators in young patients without easily detected lung disease. The investigations summarized by Fidler et al examined relationships between changes in sweat chloride concentrations and FEV1 across several CFTR modulator trials. The results of this comprehensive review indicated that negative changes in sweat chloride were associated with positive changes in lung function (FEV1 percent predicted) in aggregate but could not predict individual patient responses. This is an important consideration for clinical application, as relying on changes in patient sweat chloride concentration is not clearly beneficial in determining responsiveness to modulator treatment. Finally, the studies reported by Adam and et al examined smooth muscle and small airway distensibility following initiation of ivacaftor therapy. These studies build on prior investigations of CFTR activity and smooth muscle function in newborn piglets with CF (ie, Fidler et al, reviewed herein). The studies ask whether some of the ivacaftor benefits observed in patients with the G551D CFTR mutation may reflect effects on smooth muscle function. The results provide evidence that some of the acute changes (within 48 hours of starting ivacaftor) are due to smooth muscle dilation rather than reflecting only the restoration of mucociliary clearance. These studies identify a novel mechanism contributing to airflow obstruction in CF, which may be beneficial to advancing new therapies and to improving patient management. CFTR modulators are typically well tolerated, but regular monitoring of lung function tests for patients treated with either ivacaftor or lumacaftor/ivacaftor, and for cataracts (for children treated with ivacaftor or lumacaftor/ivacaftor) is recommended. These drugs can have interactions with other CF therapies (eg, rifampin and antifungals), which should be considered during cotherapy and may require adjustment in dosing. Finally, treatment with lumacaftor/ivacaftor can produce chest tightness in some patients with CF, which can usually be managed with inhaled bronchodilators and/or slow dose escalation. These symptoms usually resolve within one to two weeks of starting treatment. Overall, the results of these studies provide several key points relevant to CF care. First, in addition to the short term benefits measured in clinical trials, CFTR modulators appear to affect the long term trajectory of lung decline. This is seen with both highly active CFTR modulators (eg, ivacaftor treatment of patients with CF with the common gating mutation G551D), and modestly active CFTR modulation (eg, lumacaftor/ivacaftor in patients with CF with two copies of the F508del CFTR mutation).Second, patients with one copy of F508del CFTR mutation and a second mutation that has minimal function do not receive clear benefits from lumacaftor/ivacaftor treatment, despite some improvements in sweat chloride and symptoms. This highlights the need for more effective therapies for this population, and the need for more sensitive, clinically relevant biomarkers of restored CFTR activity. Third, the lung clearance index (LCI) may serve as a more sensitive biomarker of lung function improvement than FEV1 percent predicted, as young patients with two copies of F508del CFTR and normal baseline lung function demonstrate improvements in LCI (and sweat chloride), despite no improvements in FEV1. Finally, a novel mechanism of action of CFTR modulators may include relaxing bronchial tone, helping to reduce airway obstruction. |
G551D Mutation Modification by Ivacaftor |
Sawicki GS, McKone EF, Pasta DJ, et al. Sustained Benefit from ivacaftor demonstrated by combining clinical trial and cystic fibrosis patient registry data. Am J Respir Crit Care Med. 2015 Oct 1;192(7):836-842.
Clinical trials in patients with CF possessing at least one G551D mutation and treated with ivacaftor have demonstrated clear pulmonary and nutritional benefits,1 raising the question whether prolonged ivacaftor treatment might produce sustained improvements in both lung function and nutritional parameters compared with controls. In the current study, the investigators compared the impact of prolonged ivacaftor therapy on pulmonary function and nutritional status in patients with CF caused by the G551D mutation compared with CF patients homozygous for the F508del mutation. The research team designed a propensity scoring process to match patients ≥ 6 years of age and a G551D CFTR mutation treated with ivacaftor in clinical trials for up to 144 weeks. They compared those scores with data from F508del homozygous patients in the U.S. Cystic Fibrosis Foundation Patient Registry. The matching was based on a variety of variables that included age, sex, weight for age, height for age, body mass index for age, FEV1 percent predicted, and conventional chronic therapies commonly used to treat CF (including dornase alfa, inhaled antibiotics, and inhaled and oral corticosteroids). The study team showed that the ivacaftor-treated subjects had a rapid increase in FEV1 of 8.29 percentage points above controls. Importantly, this difference increased one and two years after initiating the drug, and the loss of lung function for the ivacaftor-treated group was reduced to -0.91% per year, while the F508del/F508del group demonstrated a loss in lung function of -1.72% per year. Treatment with ivacaftor also led to improvements in body mass index and weight-for-age z scores for the ivacaftor-treated patients with G551D over the three-year period of observation. These findings provided support for the notion that ivacaftor is a disease-modifying therapy for the treatment of cystic fibrosis. References:
Lumacaftor/Ivacaftor in F508del Homozygous Patients — Long Term Benefit |
Konstan MW, McKone EF, Moss RB, et al. Assessment of safety and efficacy of long-term treatment with combination lumacaftor and ivacaftor therapy in patients with cystic fibrosis homozygous for the F508del-CFTR mutation (PROGRESS): a phase 3, extension study. Lancet Respir Med. 2017 Feb;5(2):107-118.
Two randomized, blinded, placebo-controlled trials have demonstrated safety and efficacy of lumacaftor/ivacaftor combination therapy in patients with cystic fibrosis ≥ 12 years of age and homozygous for the F508del-CFTR mutation.1 In the current trial, the study team aimed to assess the long-term safety and efficacy of lumacaftor/ivacaftor treatment in this group of patients during open-label extension. This PROGRESS study was a phase 3, parallel-group, 96-week evaluation of patients who completed the placebo-controlled portion of the study (TRAFFIC or TRANSPORT) across 191 study sites in 15 countries. Patients who had previously received active treatment in TRANSPORT or TRAFFIC remained on the same dose in the subsequent trial, while patients who had received placebo were randomly assigned (1:1) to receive either lumacaftor (400 mg every 12 hours)/ivacaftor (250 mg every 12 hours) or lumacaftor (600 mg once daily)/ivacaftor (250 mg every 12 hours). The primary outcome focused on demonstrating the safety of prolonged combined therapy. The estimated annual rate of decline in FEV1 percent predicted in the lumacaftor/ivacaftor-treated patients was compared with that of a matched cohort from the U.S. Cystic Fibrosis Foundation Patient Registry. Some 1030 patients from the TRANSPORT and TRAFFIC studies enrolled in this active treatment study: 340 patients continued treatment with lumacaftor 400 mg/ivacaftor 250 mg every 12 hours, and 176 patients who had received placebo during the placebo-controlled studies initiated treatment with lumacaftor 600 mg daily/ivacaftor 250 mg every 12 hours. During the active treatment study, the most common adverse events included infective pulmonary exacerbations, cough, increased sputum, and hemoptysis. Modest increases in blood pressure were also observed during the extension study. For patients continuing treatment, the mean change from baseline in FEV1 percent predicted was 0·5% (95% CI -0.4 to 1.5) at extension week 72 and 0.5% (-0.7 to 1·6) at extension week 96. In this group, the change in BMI was 0.69 (0.56 to 0.81) at extension week 72 and 0.96 (0.81 to 1.11) at extension week 96. The yearly rate of pulmonary exacerbations in patients who continued treatment through 96 weeks (0.65, 0.56 to 0.75) was lower than that observed in the control arm from the placebo-controlled trials. Yearly decline in FEV1 percent predicted was reduced by 42% in lumacaftor/ivacaftor-treated patients compared with matched controls (-1.33% per year, -1.80 to -0.85 vs -2·29, -2.56 to -2.03). Similar benefits were observed in the patients treated with lumacaftor 600 mg once daily/ivacaftor 250 mg every 12 hr. The long-term safety of lumacaftor/ivacaftor combination therapy was similar to that observed during the randomized, placebo-controlled trials. These findings provided support for the notion that lumacaftor/ivacaftor is a disease-modifying therapy for the treatment of cystic fibrosis in patients homozygous for the F508del CFTR mutation. References:
Pulmonary Benefit of Ivacaftor/Lumacaftor in Adults Heterozygous for a F508del CFTR Mutation |
Rowe SM, McColley SA, Rietschel E, et al; VX09‐809‐102 Study Group. Lumacaftor/Ivacaftor Treatment of Patients with Cystic Fibrosis Heterozygous for F508del-CFTR. Ann Am Thorac Soc. 2017 Feb;14(2):213-219.
Short term (28 days or less) treatment of patients with one copy of the F508del mutation with lumacaftor/ivacaftor did not improve lung function.1 This study was designed to evaluate a lumacaftor/ivacaftor dosing regimen based on large studies and a longer treatment duration in a cohort of patients with one copy of F508del. One hundred twenty-six patients were enrolled and 119 completed the study. Lumacaftor/ivacaftor was generally well tolerated, but an increased incidence of chest tightness and dyspnea was observed more frequently with the active drug compared with placebo (27.4% vs 14.3%, and 14.5% vs 6.3%, respectively). The baseline FEV1 percent predicted was 62.9 (14.3) in the lumacaftor/ivacaftor group and 60.1 (14.0) in the placebo controls. The absolute change in FEV1 percent predicted (least squares mean [SE]) at day 56 of treatment was -0.6% (0.8) in the lumacaftor/ivacaftor cohort and -1.2% (0.8) in the placebo controls (P = .60). Respiratory symptom scores improved by 5.7 points (mean) compared with a decrease of -0.8 in the placebo controls (P < .01). Body mass index (BMI) did not change in either group, but sweat chloride concentrations increased significantly from baseline in the lumacaftor/ivacaftor group. Sweat chloride in lumacaftor/ivacaftor-treated subjects dropped -11.8 mMol (1.3) (least-squared means, SE) by day 56, while there was no change in the placebo arm [-0.8 mMol (1.2); (P < .0001)]. However, despite significant changes in sweat chloride and pulmonary symptoms, lumacaftor/ivacaftor treatment failed to produce measurable benefits in lung function or BMI in adult CF patients heterozygous for the F508del CFTR mutation and moderate lung disease. References:
Ivacaftor/Lumacaftor in Patients Aged 6-11 Years with Two F508del CFTR Mutations |
Milla CE, Ratjen F, Marigowda G, Liu F, Waltz D, Rosenfeld M; VX13-809-011 Part B Investigator Group. Lumacaftor/Ivacaftor in Patients Aged 6-11 Years With Cystic Fibrosis Homozygous for F508del-CFTR. Am J Respir Crit Care Med. 2016 Nov 2.
Prior studies have demonstrated that the combination of lumacaftor/ivacaftor improves lung function and other clinical outcome measures in patients > 12 years of age with two copies of the F508del mutation.1 This open-label phase 3 trial was designed to evaluate the safety, tolerability, pharmacodynamics, and efficacy of lumacaftor/ivacaftor treatment in pediatric patients with CF aged 6-11 years with two copies of the F508del mutation. Fifty-eight patients were treated with 200 mg lumacaftor/250 mg ivacaftor orally every 12 hours for 24 weeks. All patients continued their baseline CF therapies. Lumacaftor/ivacaftor treatment was generally well tolerated, and the safety profile was similar to that reported in the larger TRANSPORT and TRAFFIC trials conducted in older CF patients. Four pediatric patients discontinued the study drug, with two due to drug-related adverse events (elevated liver transaminases, n = 1; rash, n = 1). No pulmonary function safety concerns were observed. There were no significant changes in FEV1 percent predicted over the study (change from baseline at week 24, +2.5 percentage points; 95% CI, -0.2 to 5.2; P = .067). However, at week 24, significant reductions from baseline were observed for sweat chloride concentration (-24.8 mMol; 95% CI, -29.1 to -20.5; P < .0001) and lung clearance index (-0.88; 95% CI, -1.40 to -0.37; P <.002). Significant improvements also occurred in BMI z score (+0.15; 95% CI, 0.08 to 0.22; P < .0001) and respiratory symptoms as reported by the Cystic Fibrosis Questionnaire-Revised respiratory domain score (+5.4; 95% CI, 1.4 to 9.4; P < .01). The results of this study provide evidence that lumacaftor/ivacaftor treatment is well tolerated in younger CF patients, with no new safety concerns observed. While a control group was not included, the study provided evidence for drug bioactivity (changes in sweat chloride) and potential clinical benefits (improvements in BMI, LCI, and respiratory symptoms). References:
Sweat Chloride and FEV1 in Patients Treated with Ivacaftor |
Fidler MC, Beusmans J, Panorchan P, Van Goor F. Correlation of sweat chloride and percent predicted FEV1 in cystic fibrosis patients treated with ivacaftor. J Cyst Fibros. 2017 Jan;16(1):41-44.
Ivacaftor is a well described CFTR potentiator that improves the gating function of CFTR. It has been extensively evaluated in CF patients with various CF-causing mutations and has demonstrated its greatest clinical impact in CF patients with gating mutations. Previous reports have examined whether relationships exist between changes in sweat chloride values and changes in lung function as measured by FEV1 percent predicted in patients receiving ivacaftor treatment.1,2 To date, no statistical correlation has been demonstrated between these parameters. The primary goal of the post hoc analysis in this manuscript was to expand on prior studies and explore correlations between changes in sweat chloride concentrations and FEV1 percent predicted, using data from multiple study cohorts with different CF-causing mutations treated with ivacaftor. During examination of individual studies, changes in sweat chloride levels and improvements in FEV1 percent predicted failed to correlate for individual patients. However, when the data from all studies were evaluated together, clear and statistically significant correlations between changes in sweat chloride concentrations and FEV1 percent predicted were observed (P < .0001). This data analysis indicates that changes in sweat chloride concentrations produced by potentiation of CFTR with ivacaftor predict lung function changes on a population level, but do not clearly predict treatment benefits in individual patients. References:
Acute Benefits of CFTR Modulation |
Adam RJ, Hisert KB, Dodd JD, et al. Acute administration of ivacaftor to people with cystic fibrosis and a G551D-CFTR mutation reveals smooth muscle abnormalities. JCI Insight. 2016 Apr 7;1(4):e86183.
It is well established that airflow obstruction is a frequent manifestation of CF lung disease, but the causative factors remain incompletely defined. In addition to mucus plugging, airway hyperresponsiveness is a common occurrence in CF, but its relative contribution to airflow obstruction is unclear. Recent studies have provided evidence that CFTR is expressed and functional in airway smooth muscle (ASM), with increased ASM tone observed in newborn CF pigs.1 These observations suggest that CFTR dysfunction produces a primary defect in ASM function (ie, prior to the development of infection and inflammation). In the current study, the research team tested the hypothesis that restoring CFTR activity via potentiation with ivacaftor would decrease smooth muscle tone in people with CF caused by the G551D mutation. Twelve adults with the G551D mutation were enrolled prior to initiating ivacaftor treatment. Patients were studied before and soon after starting ivacaftor (48 hours), with the goal of minimizing the secondary consequences of CFTR restoration. Smooth muscle function was assessed via spirometry, airway distensibility, and vascular tone testing. As anticipated, ivacaftor rapidly improved CFTR function and reduced sweat chloride concentration. Airflow obstruction and air trapping also rapidly improved. While small airways increased their distensibility, these changes were not seen in the larger airways. Smooth muscle function outside of the lung was measured via vascular pulse wave velocity (PWV) and augmentation index. Both of these smooth muscle parameters decreased following the initiation of ivacaftor. On comparison of changes in the lung and the vascular smooth muscle, the change in distensibility of < 4.5 mm airways demonstrated a correlation with changes in PWV. The results of this small study provide evidence that CFTR potentiation rapidly improved two markers of smooth muscle tone and suggest that ASM dysfunction may contribute to airflow obstruction in CF. References:
All rights reserved - The Johns Hopkins University School of Medicine. Copyright 2018. This activity was developed in collaboration with DKBmed. |


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Award-winning local news executive Rob Elmore has been named the president and general manager of ABC11/WTVD-TV Raleigh-Durham, announced Wendy McMahon, president, ABC Owned Television Stations, to whom he will report. In this new role, Mr. Elmore has overall management responsibility of the station's operations and its ancillary businesses.
Elmore is a seasoned news executive bringing extensive experience leading teams in the multiplatform space including ABC7/KABC-TV Los Angeles which serves the second largest market in the United States. As the vice president of KABC's news division for the past five years, Elmore has helped cement the station's status as Southern California's leading source for local news and information, expanding coverage to serve audiences across broadcast, digital and social platforms. Prior to KABC, Elmore spent 17 years at WTVD where he held the position of news director serving the Research Triangle Region of Durham, Raleigh, Chapel Hill and Fayetteville with the most trusted news information, entertaining content and inspiring storytelling.
"Rob has been an extraordinary and transformational leader for the ABC owned television stations, building next-generation newsrooms at ABC11 in Raleigh-Durham and ABC7 in Los Angeles," said McMahon. "Rob leads with a sharp vision for modernization and an uncompromised commitment to our communities and audiences. As ABC11 continues to press forward in innovation and growth to serve our viewers across even more platforms, we're thrilled for Rob's leadership as he returns to his Raleigh-Durham roots."
"After a great five years in Los Angeles, returning to central North Carolina and the team at ABC11 in many ways feels like a homecoming. I spent one of the most formative periods of my life and career in Raleigh-Durham, during which time I came to know and love the resiliency and the vibrancy of the community," said Elmore. "Especially with the health and economic impact of the pandemic felt so broadly, there is never a more important time for local news to support our community and business partners by keeping our audiences informed and connected. ABC11 has been there for our viewers for every step of the journey, and I'm thrilled to be coming back to this amazing team as we see our community back onto its feet."
At KABC, Elmore specialized in creating and executing content and format strategies to increase multiplatform viewership and engagement, helping to secure ABC7's position as the No. 1 station in the country on digital and social. Most recently, KABC was honored in 2020 with four Regional Edward R. Murrow Awards for Overall Excellence, Breaking News Coverage, Excellence in Video, and Best Newscast in large-market television in Region 2 of the Radio Television Digital News Association (RTDNA).
As news director of WTVD, Elmore spearheaded the opening of the first and only downtown Raleigh street-level studio, The Raleigh Eyewitness News Center, in 2005. In 2008, his team was the first in the country to deploy a live broadband mobile unit, Breaking News 1, for spot news and severe weather coverage. In 2011, he and the team created the Happening Now at 5 p.m. format, which has been replicated at local stations across the country.
Before joining ABC Owned Television Stations, Elmore was news director and assistant news director at News 10 NBC in Rochester, New York. Earlier in his career, he was a news producer at WSMV in Nashville, Tennessee, where produced the 6 p.m. and 10 p.m. newscasts; and WHAM-TV in Rochester, New York, where he produced the 6 p.m. and 11 p.m. newscasts. He began his television career as a reporter at WWNY-TV in Watertown, New York, during summer and college breaks.
Elmore graduated magna cum laude from SUNY Geneseo with a Bachelor of Arts in speech communication.
About ABC11/WTVD-TV Raleigh-Durham
ABC11/WTVD-TV Raleigh-Durham is an ABC owned television station serving the Research Triangle Region of Durham, Raleigh, Chapel Hill and Fayetteville, an area collectively known for its technology companies and scholarly institutions. In 2017, WTVD transformed into a multiplatform newsroom as the first stations selected for the UNC Knight-Lenfest Newsroom Initiative, modernizing the station and maximizing its reach and engagement across linear broadcast and streaming video on demand. ABC11 is proudly the broadcast partner for the Raleigh Christmas Parade, the largest local event in the region, and the news gathering partner with the News & Observer, the region's paper of record.
Twitter: https://twitter.com/ABC11_WTVD
Instagram: https://www.instagram.com/
Facebook: https://www.facebook.com/
About ABC Owned Television Stations
The ABC Owned Television Stations includes WABC-TV New York, KABC-TV Los Angeles, WLS-TV Chicago, WPVI-TV Philadelphia, KGO-TV San Francisco, KTRK-TV Houston, WTVD-TV Raleigh-Durham and KFSN-TV Fresno. The eight owned stations reach 23% of all U.S. television households. The stations are consistently market leaders in multiplatform local news, collectively No. 1 in local news among Adults 25-54 for 11 consecutive broadcast seasons, and in overall digital audience, video consumption and social reach and engagement. In 2018, the Stations further expanded their content portfolio and reach with the launch of the digital-first national lifestyle brand Localish that in its first year produced over 650 pieces of digital video content, totaling more than 240 million video views. The Live Well broadcast channel was rebranded as Localish in February 2020, delivering locally sourced yet nationally relevant storytelling as long-form linear programming to more than 14 million viewers across America.

subset: commoncrawl


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Little G Weevil: The Teaser.
There's a whole stratum of US bar bands which has no equivalent here in the UK. In such a huge country, with a live blues joint to fill in every sizable city and a host of local festivals too, any band worth its salt can rack up a steady 200 gigs a year. Those tough enough to survive the process emerge with a practiced showmanship and proven set-list which few British pub bands can match.
Somewhere at every one of those 200 gigs, you'll find a merchandise table selling CDs much like this one. They're expertly played and thoroughly enjoyable throughout, but stick rather too closely to the circuit's required formula to provide any real surprises. In Little G's case, that means 12 good solid blues songs, veering from John Lee Hooker to BB King in their style, and split eight/four between full band and solo arrangements.
Weevil himself provides guitar and vocals, offering up a solo in just about every number, but keeping these tight enough to avoid pointless pyrotechnics. The whole album's pitched very much towards the blues end of the blues-rock spectrum, with Bob Page and Maurice Nazzaro adding enjoyable texture on piano and harmonica respectively.
Page switches to organ for Big City Life, giving this London-inspired song a touch of soulful funk in keeping with the band's Georgia base. Other highlights among the full-band performances include the opening rocker Real Men Don't Dance, the brooding Highway 78 and Liquor Store's twitchy stop-start harmonica riff. I'm less keen on the slow blues of Apple Picker, the one track where Weevil does drift into a fancy-pants solo, but no doubt it keeps the casual Clapton fans in his audience happy.
Weevil acknowledges John Lee Hooker as one of his heroes, a fact we might have guessed from the solo tracks here. With their remorselessly hypnotic riffs and the metronome-steady tap of Weevil's foot for percussion, these four songs keep us firmly locked into their tales of good love gone bad. Losing Cool's sense of subdued violence and Which Way Shall I Go's bottleneck work stand out.
What we have here, then, is an accomplished, dependable blues album. It's a little short on innovation, perhaps, but get a couple of beers inside me at one of Weevil's gigs, and I'll be first in the queue at that merchandise table.
This review first appeared in fRoots 347. For more details, visit the magazine's website here.


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Daily Bulletin | Thursday
White Day
Tomorrow will be a Gear Day! Visible SJA Gear on top, with dress code appropriate bottoms!
A final reminder that Jenks Studio is here taking photos on the Fuller Hall stage. Juniors- please remember to stop by Fuller Hall today if you haven't already! Any Freshman or Sophomore who missed their scheduled time earlier in the week are also encouraged to stop by Fuller today. As a reminder, even if you do not plan to order photos, we still need you to have your picture taken, as these are the photos we use for the yearbook.
Attention all students taking this Saturday's SAT exam. There are certain items you must have with you in order to be admitted. You must have a valid photo ID issued either by the school or your home state. You may also use your passport. You must have a printed version of the official College Board admission ticket (it may not simply be saved on a smart phone – it must be a hard copy). That ticket must also have your photo on it. In addition to bringing those essential items, you will want to bring the following: a scientific calculator with extra batteries, number two pencils (mechanical pencils are not allowed), and some snacks to eat during your breaks. Cell phones will be collected in all testing rooms. If you can do without your phone, it might just be better not to bring it. Please dress comfortably. If it's raining in the morning or if it's especially cold, be sure to dress accordingly for the wait outdoors. Finally, you must wear a mask at all times. The doors to Colby Hall will open at 7:45. The doors will lock at 8:00. We look forward to greeting you there.
Calling all College Bound Hilltoppers! The following colleges have visits today: Plymouth State University at 10am —Colby Conference Room; University of Southern Maine—Zoom at 10:30am; Lincoln Technical Institute – East Windsor at 11am—CTE Department; Dean College at 11:30am—R112; University of Maine at Farmington at 12:30pm—Colby Conference Room; Gettysburg College—Zoom at 1pm; University of Vermont (Seniors Only) at 1:30pm—Colby Conference Room; and Wheaton College-Massachusetts at 2pm—Colby Conference Room. Please be sure to sign up for their visits on Naviance and to view all details. If you are scheduled to be in class during the time of the visit, please check in with your teacher before coming to the college visit.
The following colleges will have virtual Zoom visits tomorrow: Colgate University, University of California-Riverside, and Emmanuel College. Be sure to visit Naviance to sign up for all college visits.
Juniors and seniors that are applying to join the Colwell Scholars (or are thinking about applying) should meet with Mr. Ehrean after school on Thursday in Ranger 115.
If you're interested in attending the virtual visit with Dr. Spoon tonight, please RVSP at bit.ly/SpoonZoom by 3:00 or see Ms. Drew.
All St. Johnsbury Academy students are invited to attend tap-sensation, Dorance Dance, in concert at Lyndon Institute on Tuesday, October 5th. All students may attend this show for free, which includes younger siblings not yet at SJA. There is no charge, but all students will need tickets to be admitted. Free student tickets can be found at: https://tickets.catamountarts.org/shows/dorrance%20dance/events or by calling the Catamount Arts box office at 802-748-2600 ext. 3. Please see Mrs. Hraibi in the Dance Studio – Morse 101 if you have questions. And please do a "Dorance Dance" Google search and enjoy the super-tap dancing you can see live and for free this Tuesday. Masks, proof of vaccination (or PCR Test), and valid ID are required to attend this show.
Are you interested in civil discussion and debate? Do you want to talk with people you may not agree with about issues that matter to you? Do you want to build empathy and understanding while connecting in a fun and safe environment? If so, Discussion and Debate club is for you! We meet in Colby 209 on Thursdays from 3:30 to 4:30. That's today! In Colby 209 at 3:30. See Mr. Weiss with any questions or for more details.
Happy Birthday today to Erin Conley, Indigo Farlice, Shinnosuke Inasawa, and Madeline Woodson!
JV-B BOYS SOCCER vs. SOUTH BURLINGTON 4:30, please release the team at 3:00
Girls Varsity Soccer lost to Colchester, 3-1, and the JV team lost, 2-0.
Varsity Volleyball lost to South Burlington, 3-1; however, the JV team beat South Burlington, 2-1.


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Published on: 03/09/2020
He Retired the Week the Dow Slid 12%. Consider It a Wake-Up Call to Check Your Portfolio.
Tracy Donaldson, of Orlando, Fla., had an inauspicious start to retirement. The Dow Jones Industrial Average plunged 12% in the week he retired. "This is very disconcerting and very bad timing," says Donaldson, 66 years old, who retired on Feb. 28 after a 38-year career at Walt Disney in travel and logistics coordination. "I decided not to look at my investments so I wouldn't be depressed and upset."
See Full Article


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The film portrays the origin story of the initial encounters between the humans and the orcs, with an emphasis upon both the Alliance's and the Horde's sides of their conflict. Featuring characters such as Durotan and Lothar, the film will take place in a variety of locations established in the video game series. Enjoy our #Warcraft wallpapers hd for widescreen monitors, tablets, dualscreens and iphones/mobile phones :]
For multiple download simply select the walls you want using the tick and then go to your download cart.


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We're a little late with this, but...
Dave will be conducting a brief sort-of workshop on Travel Photography this Saturday, July 11 at 2pm in Kuala Lumpur, at the MPH Bookstore in Utama 1. His (illustrated) presentation will last about an hour, and he'll hang around a bit afterwords if want to chat about photography. If you'd like to check out Dave's work beyond this blog (and beyond food) hop over to his photography website (recently updated) or his photo blog.
Dave's presentation is in conjunction with a pretty neat photo contest being put on by CIMB Bank, in which you can earn up to RM100,000 for your favorite charitable cause. (The photos on the site are Dave's.) Stop by to listen and watch or just to say 'hi'. He'd love to meet you.
UPDATE July 10: The previously posted time of 1030a is wrong -- Dave's talk is at 2pm. Hope to see you there!


text: Logility Inc. and AdapChain, a certified SAP integration partner, have simplified the process of connecting SCM-to-ERP applications. Pre-built integration templates eliminate the need to specify, develop, test, and debug new components. These templates contain detailed mappings of associated processing logic, creating a comprehensive framework for successive integration efforts. Because the template itself sets the design direction, it is easier for developers to create enhancements that can be understood and further extended by others.


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Our houses are filled with appliances. Appliances are like the backbone of the house. Once they start malfunctioning, it gets a very difficult day. For instance, having leakage in pipes or a blockage in the sink can be a real pain for the day. One would start to feel frustrated if it was not repaired as soon as possible. Moreover, the longer it is dysfunctional, the likely it can ruin other things in your house as well. For example, leakage in pipes can cause sealing in your walls and wooden furniture, especially.
Blockages especially are super hard to deal with. Once a drain is blocked, your drain water gets stagnant, making the place more unsuitable. It must be cleaned up and repaired as soon as possible.
What causes blockage?
So what ideally causes blockage? It is very much expected that blockage can result from all the unnecessary material that gets filtered in the sink, has entered the pipe, and has choked the pipe. As a result of that, the water that was supposed to pass through it, unable to complete the course and move out to the outlet.
Remedies for a clogged drain
To avoid blockages, one must take precautionary methods such as installing a filter above the pipe inlet. This shall filter all the necessary waste from entering the pipe. Moreover, keep cleaning the filter regularly. Ensure that the filter is cleaned frequently so that it can function well. Generally, things such as food material, hair strands, small plastic pieces, grains, sand, or anything small can enter the pipe and clog the opening.
How to get started with fixing?
One of the primary rules you can make in your house is to avoid wasting down any waste material down the drain; you prefer throwing things in the dustbin rather than shoving it into the drain. This will help in decreasing the frequency to waste accumulating at the drain. Even if it is liquid waste such as a paste or wax, it is always better to dispose of it in the dustbin than in the drain.
If you find your drain clogged by some thick liquid, for instance, wax or clay, and you cannot remove it, you can try to get rid of it using a very basic home remedy. Take a pan of hot water and add some vinegar or baking soda to the water. Pour the water over the clogged area. This will help the thick liquid melt and either pass through till the sink's outlet easily, or even you can scrap it off well without applying much effort.
Likeliest places to suffer from blockages
Your drain of the bathroom and the kitchen are the likeliest places that can suffer blockage as these are the two most used areas of the house. No matter how many people live in a house, even if only one person is living, such unfortunate instances can happen anytime.
Call maroussi blockages
If you are suffering from a blockage, it is understandable how much of a struggle your day can be. But there is something that can be done about it. Pick up your phone and call an expert, call αποφραξεις μαρουσι. They have a team of professionals that help you get rid of the clogged drain so that it can start being functional as soon as possible. They can help you fix your drain in the house anywhere, in the parking area, bathroom, kitchen, balcony, etc., at a reasonable price.
So, therefore, now you know, if it's a blockage, call maroussi blockages. They are the experts to solve all your blockage related issues within no time and with professionalism.


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Massachusetts Gov. Charlie Baker signed a pro-abortion bill Friday to keep the killing of unborn babies legal in the event that the U.S. Supreme Court overturns Roe v. Wade.
"It's a good day for Massachusetts," Baker said, prior to signing the bill, Patch reports.
Surrounded by abortion activists, the pro-abortion Republican celebrated the N.A.S.T.Y. (negating archaic statutes targeting young) Woman Act, which repeals several century-old state laws that ban abortions. The legislature approved the bill last week.
"Today, we formally repeal a number of antiquated laws, some of which could lead to denying young women reproductive health care," Baker wrote on Twitter afterward. "These laws do not represent Massachusetts' leadership on these issues or the shared goal of protecting women's access to health care."
Pro-abortion lawmakers pointed to President Donald Trump's nominee to the U.S. Supreme Court, Brett Kavanaugh, as a reason for their urgency in passing the legislation. If confirmed, Kavanaugh could swing the court to a 5-4 conservative majority and be a deciding opinion on vital issues like abortion restrictions and Roe v. Wade.
House Judiciary Committee Co-chair Rep. Claire Cronin told the State House News Service as much in an interview.
"We have both a president and a vice president who have expressed an intent to overturn Roe v. Wade and we take them at their word," Cronin said. "We must ensure that if this occurs, in Massachusetts we have taken the necessary steps to protect the right to choice and to protect the right to access to health care and access to the information need to make private medical decisions. These will be upheld."
Anne Fox of Massachusetts Citizens for Life said abortions would still be legal in Massachusetts post-Roe, even without the legislation.
"They claim, that, if or when Roe v Wade is overturned, those old laws will kick in and abortion will be illegal in Massachusetts. That would be wonderful but it is exactly the opposite of the truth," Fox wrote on the pro-life organization's blog.
"The truth is that Massachusetts is one of the 15 states which have abortion enshrined in their state Constitutions. Overturning Roe v. Wade will change nothing in the state," she continued.
She said Massachusetts cannot pass abortion restrictions unless it amends the state constitution.
In an interview with One News Now, Fox said state lawmakers had political motivations for the legislation.
"Obviously it's part of their talking points," Fox said. "They're all saying the same thing, but it raises money for them – it chins up their supporters, so they do it."
Boston Magazine, a liberal, pro-abortion news outlet, also highlighted the political motivations of the legislation, writing:
It's largely symbolic, and designed to make a loud political statement—which it has, as the cleverly named law has attracted plenty of national attention. The state hasn't enforced its anti-abortion or anti-contraception laws in a very long time, a state Supreme Judicial Court decision in 1981 backed up the right to an abortion, and our deep-blue leadership is unlikely to try to restrict access anytime soon, Roe or no Roe.
Still, good riddance.
Though the situation is discouraging, Fox has not given up hope. She said pro-lifers in the state must double their efforts to restore protections for unborn babies.


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A cover crop is a crop specifically planted to:
protect the soil from erosion
suppress weeds
maintain soil moisture
increase organic matter in the soil
recycle soil nutrients
Cover crops or "green manures" are not harvested, but rather contribute to soil improvement in the place where they are grown. Most gardens benefit from the use of cover crops when not planted, instead of leaving the garden fallow (unplanted). If the garden is in use for most of the year, arrange crops into warm- and cool-season groups. This makes it possible to rest a portion of the site for cover cropping. Cover cropping is a valuable component within a crop rotation plan for pest and disease management. Cover crops are divided into two primary groups: legumes and non-legumes.
Legumes have the ability to "fix" atmospheric nitrogen gas into "soil nitrogen", which is available to plants. The fixed nitrogen will be available in the soil after the legume is terminated and starts to decompose. This fixed nitrogen allows the garden to rely less on added synthetic fertilizer. Cover crops will not supply all of the nitrogen needed for the following year, but over time will improve soil structure and nutrient levels for long-term sustainable growth.
Non-legumes are planted primarily to provide biomass, i.e. carbon-based plant material that includes stems, roots and leaves. This biomass improves the structure and water holding capacity of the soil while feeding beneficial soil microbes. Non-legumes consist mostly of grain crops such as oats, rye, and buckwheat, but several brassica crops like mustard, turnip, and daikon radish are also valued non-leguminous cover crops. Natural chemicals (glucosinolates) produced in the roots of particular brassica crops have shown promise for the management of some soil borne pathogens like nematodes, but results are inconsistent and research is ongoing.
Proper use of cover crops will improve the overall productivity of the soil. While the cover crop is growing, it will help prevent soil erosion and assist in weed control. The organic matter provided when a cover crop decomposes will improve soil structure and aeration, water and nutrient-holding capacity, and supply a portion of the nutrient requirements for subsequent crops. The type of cover crop and the length of time it is growing will determine how much organic matter and nutrients are returned to the soil. A legume may provide more nitrogen, but less total organic matter than a vigorously growing non-legume like sorghum-sudangrass.
Cover Cropping Basics
Before sowing the cover crop, turn over the garden with a rotary tiller. Clear the area of weeds and any remaining refuse from the vegetables or flowers that were not previously removed from the site. Level the soil with a garden rake. Sow seed by hand for small areas, broadcasting as evenly as possible. Broadcast back and forth over the area several times in an attempt to distribute the seed evenly. Lightly cover seeds by raking to ensure good seed to soil contact. Larger areas may require seeding equipment. In some years, irrigation may be necessary to ensure a good stand.
For maximum benefit, a cover crop should be terminated (killed) while in the flowering stage. At this point, the crop will return the greatest amount of biomass and nutrients to the soil. If cover crops are not terminated before seed formation, then their seeds may become weeds in a later crop. Once terminated, the cover crop can either be left on the soil surface to decompose as a mulch (known as "no-till"), or it can be tilled into the soil where it will decompose below the soil surface. If the no-till option is used, the cover crop will need to be mowed or crimped down prior to planting of the vegetable crop.
Cover crops that are tilled into the soil will usually need to be mowed or otherwise chopped prior to tilling. Time cover crop seeding so that the cover crop is terminated and tilled under about three weeks to a month prior to planting the vegetable crop. This will provide adequate time for the cover crop residue to breakdown before planting the vegetable crop.
Soil microbes convert the decomposing cover crop into organic matter for addition to the soil profile. Regular use of cover crops over a period of years will slowly raise the organic matter level in the soil and increase the activity of soil organisms such as earthworms and fungi in the soil. As these organisms decompose the organic materials, they help improve soil structure and tilth, making the soil a more favorable place for root development. It is important to understand that organic matter is continually decomposing and cannot be built up permanently in the soil. Soil building is a continual process in the garden.
Things to consider when choosing a cover crop:
Growing season
Nitrogen fixation for the following crop
Reduction of synthetic fertilizer costs
Addition of organic matter
Improvement of soil health resulting in increased yield
Weed control
Reduction of herbicide use
Prevention of soil erosion
Conservation of soil moisture
Water quality protection
Pollution reduction
Habitat for beneficial organisms
LayLa Burgess, Urban Horticulture Extension Agent, Clemson University Bob Polomski, Extension Consumer Horticulturist, Clemson University Debbie Shaughnessy, HGIC Information Specialist, Clemson University Cory Tanner, Horticulture Extension Agent, Greenville County, Clemson University


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Summer is upon us and that means boating, fishing and swimming! Find your place on the water this year but know what you are buying… Lake types are determined by how water enters the lake. The water sources include groundwater, surface water, the watershed and direct precipitation.
A seepage lake does not have an inlet or outlet. They are landlocked bodies of water whose main source is precipitation, runoff and groundwater. Water levels fluctuate with rainfall patterns, when there is a drought the water level drops. Seepage lakes are the most common lake type in Wisconsin.
A spring lake has an outlet, but no inlet. Groundwater flowing into the bottom of the lake from the immediate drainage area is the main source of water for these lakes. Spring lakes are often the headwaters of many streams. Lac Vieux Desert, a 4600 acre lake in Vilas County is the headwaters of the Wisconsin River.
Like spring lakes, these lakes have an outlet, but no inlet. Their main source of water is from precipitation and drainage.. Drained lakes are the least common type lake in Wisconsin.
Drainage lakes have both an inlet and outlet. Most major rivers in Wisconsin have drainage lakes along their course. An example is the Eagle River Chain of Lakes and Lake Mohawksin in Tomahawk which are part of the Wisconsin River.
An impoundment is an artificial lake created by a dam or other structure. These are also considered drainage lakes since they have an inlet and an outlet with its main source of water coming from a stream or river. Lake Nokomis in Lincoln County is an impoundment of the Tomahawk River.
When considering lake property in Wisconsin, be sure to ask your agent what the lake type is.
Article provided by Sandy Ebben, Vice President and Manager of First Weber's Rhinelander office, is a Lake Mildred resident in Northwoods Wisconsin.
First Weber sells real estate throughout Wisconsin: Metro Milwaukee and Southeastern WI, South Central Wisconsin, Southwest Wisconsin, Central Wisconsin, Northeast Wisconsin, Western Wisconsin, parts of MN, Michigan's UP and Wisconsin's great Northwoods. You can start searching for Wisconsin real estate and Wisconsin real estate agents at firstweber.com
Thanks for reading the First Weber Wisconsin real estate & Wisconsin living blog.


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Provolone Piccante Cheese - 10 Months - 1 lb
Italy - Caseificio Montorso
A sharp version of the classic Provolone cheese, Provolone Piccante is made in the same way as regular provolone, from cow's milk cheese, using a pulled curd method that's similar to mozzarella. Known as pasta filata or "stretched out" curd, Provolone Piccante is left to age and mature, in this case 10 months. The aged provolone cheese develops a great spiciness and sharpness, with that classic saltiness and full-bodied milky flavor.
Unlike American Provolone cheese, which is soft and more "deli" like, Italian Provolone Piccante is drier and, saltier, and much more flavorful. It's perfectly suitable for grating, so feel free to grate over pizzas, pannini, or grilled cheese. It's great for melting – grating makes it even easier to melt – so incorporate it to cassserolles, baked potatoes, fondue, pasta, and risotto. In Argentina, this type of cheese is used in a grilled "provoleta", a melted, golden-crusted Provolone disc that's melted on the hot grill.
Ingredients: Milk, salt, rennet.


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Back in 2012, Fostex released their flagship audiophile headphone, the Fostex TH900. Since then, Fostex has developed the second version and has been releasing special, limited edition colors. This year, they're releasing the beautiful Sapphire Blue version, which reminds me of these awesome headphones. I heard them for the first time last year and I was blown away, so I'm excited to revisit them with this Fostex TH900mk2 headphones review.
Review of Fostex TH900mk2 Headphones
In the Box
-Fostex TH900mk2 headphones
-detachable cable (2-pin to 6.3 mm connector with OFC cable)
-carrying pouch
-headphone stand
-Driver: dynamic, 50 mm
-Type: closed-back
-Impedance: 25 ohms
-Sensitivity: 100 dB (@1 kHz, 1 mW)
-Frequency Response: 5 Hz- 45 kHz
-Maximum Power Input: 180 mW
The Fostex TH900mk2 is made with high quality materials to ensure both longevity and beauty. For example, the frame of the headphones seems to be made of aluminum so it is both strong and light. Additionally, it's striking earcups and driver housings are made of Japanese Cherry Birch. This wood is coated with a special Japanese "Urushi" lacquer. Furthermore, both the headband and earcups are coated in eggshell membrane leather.
The audiophiles in the room will be happy to know the Fostex TH900mk2 has gold-plated 6.3 mm connectors. These are attached to a high quality OFC cable.
A Quick Tangent on OFC Cables
OFC, or oxygen free copper, cables are controversial in the science world. Some engineers claim their benefits are just a marketing scheme because they have the same conductivity and impedance measurements as common copper cables. On the other hand, other electrical engineers argue their benefits due to their ability to deliver phase linearity. In other words, they they deliver all the frequencies of the audio signal at the same time. In my humble opinion based on my experience with the headphones, the OFC cable is great and delivers a quick transient response and wide dynamic range. It helps bring the music to life and is really quite important to the quality of headphones.
The Fostex TH900mk2 has a dynamic driver with a Neodymium magnetic circuit. It has a magnetic repulsion system with 1.5 tesla of magnetic flux density. This, in addition to its bio-cellulose and inorganic fiber admixer of its diaphragm contributes to its wide dynamic range and reproduction of the full frequency spectrum.
I am mentioning the soundstage of the Fostex TH900mk2 first because it impressed me so much. They had a remarkably impressive sense of spatial depth and width, especially for a pair of closed-back cans. Their quick transient response and dynamic range really set instruments apart from each other top-to-bottom as well. Midrange heavy instruments in particular expand outwards toward the edge and leave lots of space in the upfront and center position for the vocal.
Low Frequencies
The low frequencies of the Fostex TH900mk2 are dynamically quick and expansive. They have a real sense of extension and subbiness which makes them extraordinary for electronic, pop, and hip-hop music
The low synth pads of Lorde's The Louvre, creates this giant bed underneath the tune with lots of space between those subby synths and the rest of the low-midrange synth layers. Additionally, the all encompassing bass of Biggie's Machine Gun Funk provides even more energy to the already dynamic track. The headphones' quick transient response also makes that low low bass have great detail in the pitch of the bass so it has a sense of clarity and confidence that other headphones don't quite offer.
Middle Frequencies
The middle frequencies feel a bit scooped in the Fostex TH900mk2. However, they are clear and make room for details in the low mids and high mids alike. The emphasis and clarity in the low mids provide thickness and energy to otherwise midrange heavy instruments like guitars
For example, Weezer's song, Getchoo, has good separation between the kick and bass but those big, wide electric guitars blend (in a good way) with the bass to make it feel huge. However, there is just about as much emotional energy in the high mids which is particularly emphasized for vocals and can sometimes feel a bit spikey depending on the mix.
For example, Amos Lee's song, One Lonely Light, clearly demonstrates that vocals sit louder in the mix with these headphones than others. But it doesn't feel harsh, it just feels more present.
This high-mid emphasis consequently sometimes takes away from jazz music like John Coltrane's Expression. His sax doesn't balance as well with the piano and cymbals as with headphones with a flatter response. Therefore, jazz, classical music, and other genres dependent on flat midranges aren't the right tunes for these cans.
High Frequencies
The high frequencies, like the lows, are nice and extended. For example, when listening to Cyndi Lauper's Girls Just Want to Have Fun with the Fostex TH900mk2, the bright, wide synths had a real sense of air. Additionally, the gated reverbs also had a lot of detail and space; very tight, very precise. Likewise, Michael Jackson's Human Nature had lively air on his vocal and the shakers with lots of brightness and detail smoothly and consistently from left to right. Additionally, the delays and reverb of the background vocals were loud and clear, adding energy to their sections of the song.
In conclusion, the Fostex TH900mk2 is a really awesome set of headphones. It has a wonder soundstage, impressive low end extension, and shimmering highs. This is a headphone that responds best to electronic and synthesized music with vocals, so pop, hip-hop, and EDM are the best for them.
The Fostex TH900mk2 is available for the best price here:
Fostex TH900mk2 Special Edition Sapphire Blue at Audio 46
Fostex TH-900 MK2 Limited Edition Pearl White
Fostex TH900mk2 Limited Edition Emerald Green on Amazon
MajorHiFi may receive commission through retail offers.
Compare the ranking of various headphones, earbuds and in-ear monitors using our tools.
Discuss this, and much more, over on our forum.
---MAJORHIFI may receive commissions from retail offers.


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- Nov 10, 2017
- 3,280
Today, Nvidia announced a new wave of laptops featuring its GeForce RTX 30 series of graphics cards, many of which are available today. Among the announcements are two new GPUs that have been teased a few times in the past, the GeForce RTX 3050 Ti and RTX 3050. These are naturally the cheapest of the RTX 30 series lineup, and they bring the power of RTX to the "most mainstream audience yet", according to Nvidia, with prices starting at $799.
According to Nvidia's product page, the GeForce RTX 3050 Ti packs 2560 CUDA cores with clock speeds ranging between 1035MHz and 1695MHz, while the RTX 3050 has 2048 CUDA cores running anywhere between 1057MHz and 1740MHz. VideoCardz also reports that the RTX 3050 Ti has 20 RT cores and 80 Tensor cores, while the RTX 3050 has just 16 RT cores and 64 Tensor cores. Both have 4GB of GDDR6 RAM with a 128-bit memory channel interface, and a TDP that can range between 35W and 80W.
Full article, the laptops name/models and images
Nvidia announces the RTX 3050 Ti and 3050 GPUs for laptops, coming this summer
Nvidia has announced a new wave of laptops based on RTX 30 series GPUs is available today, but the company also revealed that the new RTX 3050 Ti and RTX 3050 will be available this summer.


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It's hard to beat a comforting Italian dish such as this. Hearty, delicious and only takes minutes to get ready for the oven. Then you can do something else 😉
Simple Chicken Cacciatore Casserole
4 chicken pieces, your choice, uncooked
2 cans (15 oz) Italian style diced tomatoes, I like Muir Glenn
2 jars (6 oz) sliced mushrooms, drained or 1 pkg. fresh, sliced
1 Tbsp. dry Italian seasoning mix
1 Tbsp. dried parsley
Some fresh basil leaves and black olives for garnish, if desired
Cooked rice or gluten free pasta for serving
Preheat the oven to 350 degrees. Lightly oil a casserole dish that will fit the chicken pieces. It should be at least 2″ deep to hold the tomatoes and juice.
Place the chicken in the casserole dish. Pour the 2 cans of diced tomatoes over the top, spread them around to cover the chicken and then add the sliced mushrooms on top.
Sprinkle the dry Italian seasoning mix and the dried parsley over everything.
Cover tightly and bake in preheated oven for 1 hour (more or less depending on your choice of chicken pieces), until chicken is cooked thoroughly.
Take out of the oven and sprinkle with fresh basil leaves and black olives.
Serve with cooked rice or gluten free spaghetti. There should be plenty of sauce.
Will serve 2 to 4 (depending on what kind of chicken you choose. Drumsticks or thighs will feed two people, chicken breasts will feed four).
Go all out and add some garlic bread or gluten free rolls spread with butter and warmed in the oven.
A nice red wine would be good too….. just sayin'.
Your Gluten Free Kitchen


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Haugarth to Lead Supervalu Merchandising, Logistics
In the latest move of the ongoing executive shuffling at Supervalu Inc., Janel Haugarth has been named executive vice president of merchandising and logistics.
Haugarth, who had been an EVP and the president and COO of the Minneapolis-based grocer's supply chain services organization, succeeds merchandising EVP Steve Jungmann, who will leave the company effective immediately.
In her new role, Haugarth will be responsible for all merchandising activities across the company's traditional retail and independent retail businesses. This move consolidates the leadership of all of the company's merchandising activities, with the exception of Save-A-Lot, under the leadership of a single executive vice president. Haugarth will continue to oversee all of the company's supply chain and logistics operations, and will report directly to Craig Herkert, Supervalu's president and CEO.
"By consolidating responsibility of our merchandising activities under Janel's leadership, we will accelerate progress on our company's business transformation," Herkert said. "This new structure will enable us to better leverage our scale with the supplier community and meet our customers' needs with the right products at the right time and at the right price."
Haugarth is a 30-year veteran of the company. "Janel is a proven industry leader, with a strong track record for delivering results," Herkert said. "Janel's experience working closely with both suppliers and independent retailers gives her a unique point of view in our industry. She has a deep understanding of what it means to be a successful hyperlocal retailer and her leadership will be critical to helping Supervalu realize its vision to become 'America's Neighborhood Grocer.'"
In addition to the numerous executive changes over the past year, Supervalu this week announced the closing of at least 20 of its stores across its divisions nationwide, including Shaw's in New England, Acme in Pennsylvania and Albertson's on the West Coast.
Supervalu Inc. operates 1,160 traditional retail stores, including 813 in-store pharmacies; 1,210 hard-discount stores, of which 876 are operated by licensee owners; and 1,910 independent stores serviced primarily by the company's traditional food distribution business.


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Mold removal is considered to be really essential in our homes and offices for couple of reason:
- Mold can cause potential health effects and symptoms associated with mold exposures include allergic reactions, asthma and other respiratory complaints.
- If mold is a problem in your home or school, you must clean up the mold and eliminate sources of moisture.
- Fix the source of the water problem or leak to prevent mold growth.
- Reduce indoor humidity (to 30-60%) to decrease mold growth by:
- Venting bathrooms, dryers and other moisture-generating sources to the outside
- Using air conditioners and de-humidifiers
- Increasing ventilation
- Using exhaust fans whenever cooking, dishwashing and cleaning.
- Molds can be found almost anywhere; they can grow on virtually any substance, providing moisture is present. There are molds that can grow on wood, paper, carpet, and foods.
Our technicians are well trained to handle any mold remediation service using our special product that is not a chemical preparation, but a biological preparation and not only removes mold from the walls, but also prevents resistance. By adding to paints, it has a lasting effect and thus makes a significant contribution to the treatment of residential, manufacturing or storage premises. it is possible to prevent the health risks that molds create in living areas. Fungi shoot millions to billions of spores into the air that can cause health problems – allergies, breathing difficulties, eye inflammations, rashes. As they grow, and as a result of their metabolism, they release ketones, aldehydes, ethers and more into the environment. They can allergy, cause headache, fatigue, bronchitis and conjunctivitis, pulmonary mycetomas and mycotoxicoses, exogenous allergic alveolitis, otomycosis, gastroenterotoxicosis.


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Here is the first teaser of Inception…
We don't know much about this film, it's so well done, so much so that Nolan has created a film of "phew", so it is good.
In the meantime a trailer worthy of the name, we offer you the first trailer. It is not so bad.
The pitch : The film is described as a feature-length film of action and science-fiction, which will take place in the dédalles of the spirit. Better, we can unfortunately tell you nothing.
Inception was directed by Christopher Nolan (The Dark Knight – The Dark Knight, The Prestige) with Leonardo DiCaprio (The Wedding Rebels, official Lies), Marion Cotillard (The Last Flight, Public Enemies) and Ellen Page (Rebellious Teen, Smart People).
Date of French release : 04 August 2009
Inception : Teaser / trailer (VF)
sent by LeBlogDuCinema. – Watch web series and movies.


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Sunday was originally supposed to be an off-day for the Detroit Tigers and New York Yankees as the series shifted to Detroit. Due to rain on Friday pushing the final seven and a half innings of Game 1 to Saturday, Game 2 was pushed back to Sunday afternoon. The game will get started at 3:07 p.m., and after it is finished, the two teams will head to Detroit for Game 3 on Monday.
Although it's not an ideal situation to have Game 2 on what was supposed to be an off-day, the good news is the Tigers can quickly put the 9-3 loss in Game 1 behind them. The turnaround from Game 1 to Game 2 is very quick, and the panic that fans are starting to feel could be eliminated with a good start on Sunday. All the Tigers really needed from the first two games was a split, and they can achieve that with a win in Game 2.
Here is a look at the Game 2 lineup for the Tigers:
1. Austin Jackson, CF
2. Magglio Ordonez, RF
3. Delmon Young, LF
4. Miguel Cabrera, 1B
5. Victor Martinez, DH
6. Alex Avila, C
7. Jhonny Peralta, SS
8. Wilson Betemit, 3B
Pitching: Max Scherzer
And here is the Yankees lineup:
1. Derek Jeter, SS
2. Curtis Granderson, CF
3. Robinson Cano, 2B
4. Alex Rodriguez, 3B
5. Mark Teixeira, 1B
6. Nick Swisher, RF
7. Jorge Posada, DH
8. Russell Martin, C
9. Brett Gardner, LF
Pitching: Freddy Garcia
For more on the Detroit Tigers, check out Bless You Boys. For more on the Tigers-Yankees series, check out SB Nation Detroit's ALDS StoryStream.


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Time to put on your dancing shoes! We are covering some of Austin's best entertainers, from live bands to solo harpists – and all the music in between! We all know how important it is to have a music guru on hand to keep your party going after your vows are exchanged! With these entertainment pros, your guests will be dancing all night long. Just you wait! Scroll through and read about what makes each of these artists top-notch.
Plush Party Band – Consider the intimate ambiance that live music can bring to a wedding. Plush Party Band knows how to make your reception a memorable one with their dynamic stage chemistry, fantastic musicianship, impressive technical production and choreographed light show. Plush Party Band is a true variety band, playing music from today's hits all the way back to jazz standards from the 1940's, which allows them to cater to all ages and demographics.
Photo: Fulleylove Photography
Dart Collective – Dart Collective consists of passionate live musicians and performers, all sharing the same goal of offering a more customized and personal approach to wedding music. Dart Collective began as a DJ collective in 2013 with the goal of enhancing experiences with fun, inclusive music. Dart's artists want to connect with your guests, keeping the event exciting while connecting with them on a different level.
Harpistry by Sarah Hall – Harpistry by Sarah Hall graces guests with her unique and romantic instrument for a magical evening with your closest family and friends. Sarah is extremely versatile when it comes to playing elegant or contemporary pieces. Whatever your style is, a harpist can amplify the the experience you wish to deliver to your family and friends!
Photo: Taylor Nicole Photo
Hype Rhythm DJ – Hype Rhythm DJ is blowing us out of the water with their musical talent! Having 500+ weddings under their belt, you are sure to have the best of the best performing at your wedding. They also recently added "Hype Rhythm Live," which pairs a drummer with a live DJ – the perfect compromise of having a DJ and a band!
Photo: Carhart Photography
Royal Dukes Band – The Royal Dukes Band is a premium, customizable 3- to 14-piece band specializing in high-energy music, at a sensible price. Their expansive song lists cover everything from Top 40 and classics to rock, country, dance and jazz. The Royal Dukes Band has regular showcases where you can see and hear them perform before deciding to book!
Photo: Brooke Taelor Photography
LeForce Entertainment – LeForce Entertainment is more than just a DJ. They bring your reception to a whole new level with a team of talented, music-adoring individuals. Offering a variety of different entertainment services, LeForce can be considered industry experts. From setting the mood with that romantic spotlight for your first dance as a married couple, to choosing only the best playlists that will keep your guests on their feet – this team is the secret to a successful party.
Byrne Rock Mobile DJ Service – With a massive selection of music, Byrne Rock knows music. This self-confessed audio addict will pack the dance floor at your reception, and create the soundtrack for your dream day. Whether you need help finding that perfect tune to walk down the aisle to, or someone to curate a custom mashup of songs to keep dinner conversation lively, Byrne Rock will make sure your wedding entertainment is as unique as you and your other half.
Photo: April Mae Creative
Looking for reception entertainment beyond music? View our Entertainment page to see our favorite photo booths and live illustrators, too!
Featured in this Post
Other Local Vendors: Byrne Rock Mobile DJ Service, Plush Party Band, April Mae Creative, Hype Rhythm, Leforce Entertainment, Harpistry by Sarah Hall, Brooke Taelor Photography, Taylor Nicole Photography, Fulleylove Photography


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FERPA: Family Educational Rights and Privacy Act
What is FERPA? It stands for the Family Educational Rights and Privacy Act of 1974. Also known as the Buckley Amendment. FERPA is enforced by the Family Policy Compliance Office of the U.S. Department of Education.
FERPA is not: A law that only pertains to public institutions. A law that is only applicable to offices that handle grades.
Rights granted to Students under FERPA include:
The right to inspect and review their own education records. The right to request to amend their education records. The right to have some control over the disclosure of information from the education records. The right to file a complaint with the Dept. of Ed. These are the main issues addressed in the FERPA policy. We will go into the specifics to clarify this further
What are Education Records?
All records that directly relate to a student and are maintained by an institution. These records can be in any media form: handwritten, print, tape, film, electronic, etc.
What Education Records are not:
"Sole Possession Records"– personal notes kept by a faculty/staff member as a memory aid if not shared with anyone else Law Enforcement Records – maintained solely for law enforcement purposes & revealed only to law enforcement agencies. Employment Records – of those whose employment is not contingent upon being a student.
What Education Records are not: continued
Medical Records - created by a health care professional used only for the medical/health treatment of the student. Alumni Records – most information collected after the student has left the institution (donations, etc). Classroom activity and homework that does not become part of the student's permanent record.
Why Comply with FERPA? It's the Law!
Failure to comply could result in the withholding of federal funds including student Financial Aid. Lawsuits caused by violations cost time and $$$. It is our ethical responsibility to hold student records in confidence in order to protect their privacy. Why comply? It's the Law. Being an institution of integrity – we want to maintain our witness to our students as well as the world at large. Failure to comply could result our losing the ability to participate in federal financial aid programs. By not complying lawsuits could arise which would cost the college time and money. It gives the college credibility when we are able to handle student information in a confidential and professional manner.
Who is and is not covered under FERPA?
Students who are or have been in attendance at a postsecondary institution and for whom the institution maintains education records are covered under FERPA. Applicants who are denied admission or who never attend are not covered under FERPA.
When do FERPA rights begin for a student?
When the student is "in attendance" as defined by the institution. For Regent University that means the student is registered for at least one class at 12:01 a.m. on the first day of the student's first term, as determined by the official university academic calendar. Our definition changed this year. Because of how we define "in attendance" you admissions folks probably do not need to worry too much that you may inadvertently violate FERPA.
What information might need to be handled in a secure way?
Any part of a student's record that is not listed as "directory" information. Registration forms Financial Information Social Security Numbers Transcripts Student information displayed on your computer screen Grades Student schedules Class assignments Class Rosters
What information can be released?
Directory Information (unless the student has placed a confidentiality block on his/her record). Information that the student has given written consent to release. Information needed by employees who have a legitimate educational interest. Information needed by certain government agencies. Forward all requests for student information to the Registrar's Office! You'll hear this phrase many times – we don't want you to have to be responsible for making the decision about whether or not it's OK to give it out. Let us handle that!
What is "directory information"?
It is information that may be released without the student's written consent (unless they have placed a confidentiality hold on their record). Institutions determine what they will classify as directory information.
Directory Information at Regent University includes:
Name Address address Telephone number Date and Place of Birth Major Field of Study Dates of Attendance Degrees and Awards Received Most Recent Previous Institution Attended Photograph Participation in Officially Recognized Activities Remember that FERPA says institutions MAY release directory information. At Regent we take a very conservative approach – we don't provide lists to anyone. It's part of our job to verify enrollment and provide transcripts, etc. but we only do this with proper authorization.
Providing Directory Information
In order to protect the privacy of our students, Regent University generally does not provide lists of directory information to outside parties. Please forward all requests for such information to the Registrar's Office.
Who can access Non-Directory Student Information?
ONLY Regent University employees who have a legitimate educational interest. Legitimate Educational Interest: A school official's "need to know" information from a student's education record in order to fulfill job responsibilities
Who else can access Non-Directory Student Information?
FIRST, Remember to forward all requests for student information to the Registrar's Office! Financial Aid Lenders. Agents of the court when the college has been issued a subpoena or court order. Schools in which the student seeks to enroll
Access to Non-Directory Student Information, continued
Certain State & Federal Agencies. Appropriate individuals in an emergency in order to protect the health & safety of the student or other persons. Under the Solomon Amendment – military recruiters.
Access to Non-Directory Student Information, cont.
Under FERPA parents may obtain non-directory information (grades, GPA, etc.) if the child is a legal dependent or the student gives written consent; however… At Regent no one, including parents and spouses, may obtain non-directory information without written consent from the student.
TAKE NOTE: Access to student records via Genisys or other computer software does not authorize unrestricted use of that information. Information on a computer should be treated with the same confidentiality as a paper record. Curiosity is not a valid reason to view student information. Records should only be used in the context of official business.
When in doubt – don't give it out
When in doubt – don't give it out! Forward all requests for student information to the Registrar's Office! REMEMBER!
IMPORTANT REMINDERS!!!! Do not leave confidential information displayed on an unattended computer. Cover or put away papers that contain confidential information when you step away from your desk.
Verify identity before discussing protected information with a student by phone. (see FERPA FAQs document to learn how) Only use students' Regent address when ing protected information. Hide recipients' names using the Bcc field when ing non-directory information to groups of students. (see FERPA FAQs document
Record Disposal Records containing Social Security Numbers, grades or any non-directory information about a student should be shredded, not just thrown in the trash.
Special Hints for Faculty
To Avoid FERPA Violations – Please: Do Not use the SSN/Student ID to post grades. Do Not leave graded tests in a stack for students to sort through. Do Not circulate a printed class list with the Student Name and SSN/Student ID.
Faculty Hints, continued ….
To Avoid FERPA Violations – Please: Do Not provide anyone with student schedules. Do Not provide anyone with lists of students enrolled in your classes. Do Not include confidential information (i.e. grades, #of credits) in a recommendation letter without the written consent of the student.
Thank you for your attention and cooperation in protecting the privacy of our students!
If you have further questions, please contact the Registrar's Office at
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Management Training in Jax Beach, FL
SuperPagesSM - helps you find the right local businesses to meet your specific needs. Search results are sorted by a combination of factors to give you a set of choices in response to your search criteria. These factors are similar to those you might use to determine which business to select from a local SuperPages directory, including proximity to where you are searching, expertise in the specific services or products you need, and comprehensive business information to help evaluate a business's suitability for you. SuperPages advertisers receive higher placement in the default ordering of search results and may appear in sponsored listings on the top, side, or bottom of the search results page.
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Oct. 26, 2013
Natural Gas Delivery Vans Support McShan Florist (Text Version)
This is a text version of the video segment Natural Gas Delivery Vans Support McShan Florist, which aired on Oct. 26, 2013.
JOHN DAVIS: Our success story this week takes us to an east Dallas, Texas, florist that has used alternative fuel in their delivery vans since 1990. McShan Florist added compressed natural gas vans to their fleet more than 20 years ago to address the growing problem of urban air pollution. In fact, they were a pioneering stakeholder in the Dallas-Fort Worth Clean Cities coalition.
The 64-year-old company delivers flowers in seven counties. Compared to diesel, the company finds CNG also reduces repair costs and produces a longer engine life. Now they're looking forward to more CNG fueling stations in their area.
BRUCE McSHAN: The infrastructure isn't the best in the world in this area. We are hoping to have a public station online next door to us within the next two months.
JOHN DAVIS: The family-owned business, which at one point had the area's largest privately owned CNG fleet, now has 38 dedicated CNG Ford E350 vans, with more in the pipeline. This flower shop certainly knows a lot about green offerings—being environmentally conscious from design to delivery.


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Dr. Julia Locke, EMEA
Targeted cancer treatment provides the best possible outcomes
Some cancer treatments can be non-discriminatory, causing damage to healthy tissues and lengthening the recovery time of the individual. It is important to give people the best possible outcome, and to minimise the side-effects of treatment that they receive. Targeted treatments are positive step forward towards this aim.
Targeted Radionuclide Therapy (TRT), or molecular radiotherapy employs radiopharmaceuticals, comprised of a radionuclide (radioactive atom) and cell-targeting molecule, which readily interacts with the malignancy, in order to diagnose and treat diseases such as cancer. The delivery of radionuclides to specific sites is much less damaging to healthy tissue than chemotherapy. Radiation is delivered in a specified dose, in the form of α, β−, and Conversion/Auger electron-emitters, to antigens or receptors and act by damaging tumours, at a genetic level, so that they are unable to spread.
New method of producing platinum radionuclides
In a recent study, Obata et al. (2019) provided details of a new method for producing platinum radionuclide, 191Pt, from an iridium target. There are challenges in producing radionuclides, which are succinctly explained in their paper. Obata et al. (2019) have addressed making the dissolution of irradiated iridium easier and demonstrated the chemical separation of platinum (IV) chloride and iridium (IV) chloride complexes through methods involving solvent extraction and ion exchange chromatography.
The researchers prepared and irradiated the target in a vertical beam irradiation system. The target then underwent dissolution. Chemical separation followed with selective reduction and solvent extraction and anion exchange chromatography, before final preparation of the Pt(IV) and Pt(II) products for use in the synthesis of platinum drugs.
Chemical separation was successfully achieved by reducing IrIVCl62- with acetaldoxime, to leave PtIVCl62- in solution. Further purification, to remove trace iridium species, was undertaken in an Omnifit® EZ Glass Column (12cm x 10mmid) connected to a peristaltic pump. The column was loaded with a 37–55 μm silica-based anion exchanger, followed by the PtIVCl62- solution, and a MeCN / HCl eluting agent. HPGe Gamma-ray spectrometry was used to analyse fractions in order to separate the platinum from the iridium. It was found that PtIVCl62- was strongly retained within the column whilst IrIVCl62- moved through with relative ease. As a result, a pure fraction was obtained.
Cole-Parmer products used in the research
Obata et al. (2019) recommend that anion exchange chromatography is performed relatively early in the process. These methods utilised an Omnifit EZ Glass Column and Peristaltic Pump, which can be purchased from Cole-Parmer.
The Diba® Omnifit EZ Glass Column is ergonomically designed, easy to use and are ideal for low- to medium-pressure applications and are resistant to many solvents used in liquid chromatography. The modular design gives you the flexibility to mix and match column sizes with different endpiece types to meet your specific requirements depending on whether media swell/contract or not. The columns are made from precision borosilicate glass which provides inertness, visibility, and performance. PEEK™ column threads support their multiple re-use, whilst superior frit placement provides good bed support and even distribution of sample and solvent flow. These columns are easy to repack and reuse due to their design and the accessories that are available.
The Peristaltic Pump of choice for this application would ideally come from the Masterflex® Ismatec® pumps that offer precise, repeatable and accurate dispensing at low flows of 0.0001 µL to 45 mL. Within this range are the IPC-N low-flow, high-accuracy models that can transfer 0.0004 mL to 11 mL per minute, which is more than ideal for pumping a dose of 0.5 to 1.0 mL/min as suggested by Obata et al. (2019). These multichannel programmable pumps feature planetary gears that drive eight stainless steel rollers in unison for smooth rotation and accurate liquid flow. The number of channels that are available are 4, 8, 12, 16, and 24. Click'n'go™ cartridges feature automatic occlusion for simplified use, fewer tubing changes, and reproducible results. Adjustable occlusion cartridges are available separately. Cartridges can be installed in one direction for low pulsation; or in the opposite direction for higher counter pressure. These models have remote control capabilities to allow operators to separate themselves from the procedure. Programming ensures that back-steps can be included to ensure drips are prevented.


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The Ranch Fire, in Azusa Canyon, northeast of Monrovia, seemed to have burned low today. Fire helicopters were still dropping water but no smoke was visible from Azusa Canyon, as you can see in the top photo here, which was taken Saturday morning. But the fire apparently kicked up again, as you can see from the bottom photo, taken Saturday evening from Monrovia. The City of Monrovia says there is "no immediate threat to our community."
- Brad Haugaard


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The day of the child in El Salvador is a national celebration that seeks to recognize the rights of the children of our country. Children's day is celebrated every October 1, although the entire month of October activities dedicated to children. In other countries of the world children's day is celebrated on dates different to ours.
In El Salvador the day of the child relates to a resolution of the Organization of the United Nations (UN), which adopted the Declaration of the rights of infants and in 1989, ratified the International Convention on the rights of the child, in 1959. Both events took place on November 20 and he was established as that day in which held international children's day, but each country held it on a different date.
How is it celebrated the day of the child
On the day of the Salvadoran children various activities to bring joy to children and to pass an unforgettable day. Usually these celebrations are accustomed to be performed in schools where they are hosts with a party full of clowns, cake, Piñatas and food.
There are also other places where is held as in the hospitals (especially at Bloom Hospital, where children are met), municipal markets, national parks, and municipal authorities.
The neighboring country of Guatemala also celebrates the day of the child on October 1.


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Integral Aura Workplace First Aid Kit Medium
The first new standard for Statutory First Aid Kits in the workplace since 1997, these kits reflect the changes in both workplace practice and risks, making them demonstrably more 'fit for purpose' in todays environment. For peace of mind, the provision of a kit with this updated content is now the only clear and definitive way for employers to demonstrate they are serious about meeting their legal obligations under the Health and Safety First Aid Regulations. Contents: 1 x First aid leaflet 1 x Contents list 6 x Medium sterile dressings 2 x large sterile dressings 3 x Triangular bandages 12 x Safety pins 3 x Sterile eyepads 60 x Waterproof plasters 30 x Alcohol-free wipes sterile 1 x Adhesive tape 9 x Nitrile disposable gloves (pairs) 3 x Finger dressing sterile 1 x Resusciade 2 x Foil blankets 2 x Hydrogel burn dressing 1 x Shears 1 x Conforming bandage