text:
Daniel Mancinelli knows the ropes
Daniel Mancinelli and One Racing have clearly understood exactly how the New Formula Renault 2.0 works. Picking up from where he left off in Valencia and Barcelona, the Italian has set another fastest time here at Magny-Cours. After two invaluable days of collective testing, which gave all the drivers the opportunity to put in plenty of laps and gather a wealth of precious information, Daniel Mancinelli set the fastest time ahead of Miguel Otegui (Epsilon Euskadi) and Arthur Pic (SG Formula).
The Eurocup Formula Renault 2.0 field assembled at the Magny-Cours circuit, where the French round of the World Series by Renault is to be held this season, for these two days of testing. This gave teams and drivers the chance to do further development work on the New Formula Renault 2.0.
On Monday, the sun was shining in Magny Cours, allowing the drivers to clock up a good number of laps out on track and gradually up the tempo. For many of them, it was first and foremost a question of getting to know the Magny-Cours circuit. Lap times soon started to improve very rapidly and, at the close of the morning session, it was Luciano Bacheta (Interwetten) who had set the fastest time with a lap in 1'38"483. Having already looked comfortable in Barcelona, the Interwetten driver proved he knows just how to handle the New Formula Renault 2.0. At the end of the day on Monday, he was still fastest ahead of Daniel Mancinelli, the in-form driver in these collective testing sessions, followed by André Negrao (Cram Competition) and Daniel de Jong (MP Motorsport).
As the drivers moved onto fresh rubber as the Monday afternoon session drew to a close, lap times started to dip under the 1'38 mark. This time, it was the turn of a Rookie driver, Alex Riberas (Epsilon Euskadi), to show what he could do. The young Spaniard, at just 16 years of age and fresh back from a Karting competition, set the fastest time of the day with a lap in 1'37"350. Despite having practically no experience in single-seater racing, this put him faster than Luciano Bacheta, Arthur Pic and Giovanni Venturini (Epsilon Euskadi), another young recruit to the ranks of Epsilon Euskadi.
On Tuesday, it was down to 'old hands' in Eurocup Formula Renault 2.0 to try and regain the upper hand. Luciano Bacheta and Daniel Mancinelli were to dominate for most of the session. But, in the end, it was André Negrao who finished the morning at the top of the timing screens, with a lap in 1'37"552. At this point, the Brazilian was fastest ahead of Daniel Mancinelli, Miguel Otegui and Kal Oscar Liiv (MP Motorsport).
The afternoon session was interrupted by its fair share of red flags, with each of the three SG Formula cars running off track at some point. Kal Oscar Liiv, one of the first drivers to switch onto fresh tyres, soon set the fastest time. But Miguel Otegui and then Daniel Mancinelli took it in turns to hit back as the session drew to a close. With a lap in 1'37"067, the Italian not only set the best time for both these days of collective testing, but also smashed the Formula Renault 2.0 lap record in the process, held previously by Jules Bianchi. It was left to Arthur Pic and Miguel Otegui to fight it out for second spot right until the chequered flag. At the close, the Spaniard finally got the better of the Frenchman. Next stop, Motorland Aragón, for two more days of collective testing.
Quote, unquote:
Daniel Mancinelli: "We are trying to find out as much as possible about how the New Formula Renault 2.0 responds to different settings and we've gathered quite a bit of information. At a circuit like Magny-Cours, the new gearbox is something that you really appreciate. For me, this car is a real pleasure to drive."
Luciano Bacheta: "In Valencia, we hardly put in any track time at all, but in Barcelona and here, we really got our development programme rolling. We were constantly up there with the leaders, which always helps you to relax and focus on the real job in hand. With the Interwetten team, we have high hopes for this season."
Alex Riberas: "I only drove a single-seater for the very first time this December! So I have hardly any experience at all. Obviously, I am satisfied with my performance. I felt very good in this car right from the word go. I'm only just 16 years old, so I am still very young. I want to do another season in Karting and then come and try my hand in Eurocup Formula Renault in 2011. That is something we are going to be talking to Epsilon Euskadi about."
Official Renault Sport Press Release


text:
Break-In at Parker Apartments
At approximately 3:22 a.m. on April 19, Campus Safety received a call about a reported break-in at the Parker Apartments. After Campus Safety officers investigated the apartment, they determined that entrance was most likely gained through an open window.
Campus Safety contacted the Hamilton Police to help out with the investigation of the crime, which is considered a felony. According to Special Assistant to the Vice President for Campus Safety Dick Matte, the lead officers of the investigation are Detective Wood from the Hamilton Police Department and Detective Sergeant Paul from Campus Safety.
Matte also reported that the case is still active and thus not much information is currently being revealed.
"We don't want to handicap our chances of successfully solving the case," Matte said.
However, Matte was able to disclose the approximate value of the stolen goods.
"Several thousand dollars of personal property has been reported missing and presumed stolen," Matte said.
Matte encouraged students to secure their rooms at all times and to contact Campus Safety if they notice any suspicious activity or have any information relevant to the break-in.

subset: commoncrawl


text:
They were decorated soldiers, sailors, airmen and marines who fought for their country and returned from overseas to build rich civilian lives.
The Holyoke Soldiers' Home Coalition has posted a virtual tribute to dozens of veterans who died after contracting coronavirus during the pandemic. (Relatives who would like their loved ones included in the tribute can visit the coalition's website, holyokesoldiershomecoalition.org.)
The pictorial — which went live in advance of Veterans Day on Nov. 11 — also honors five more who died of other causes while at the state-run care facility for veterans, and one resident who still resides there.
The coalition is a grassroots network of veterans' advocates, family members and other supporters of the Soldiers' Home since its patients and staff were ravaged by the outbreak this spring.
At least 76 veterans died of the virus while under the care of the Holyoke Soldiers' Home. Many more were sickened.
"Our Coalition hopes the public takes the time this Veterans Day to remember all of these veterans — all were sons and daughters of our Commonwealth who left home at an early age to serve our great nation. For those who died during this pandemic, we ask that you think not only of their passing by also remember their glory and spirit," an announcement by the coalition read.
The veterans featured in the tribute fought during World War II, the Korean War and in the jungles of Vietnam. Some were radio operators, aerospace engineers and specialists.
One late veteran, Emilio "Leo" DiPalma of Springfield, was a World War II sergeant in the Army and served as Sergeant of the Guard during the Nuremberg Trials. His likeness is memorialized with a wax figure in the Holocaust Museum in Virginia.
"Leo was a kind, humble family man. His top priority was caring for his wife and four daughters," DiPalma's post reads.
The men who lost their lives to the virus went on to become teachers, carpenters, members of law enforcement, civil servants and more. They married and had children, grandchildren and great-grandchildren. Some of the tributes touch upon the late veterans' hobbies, senses of humor and endearing quirks.
Robert Lapinski, 75, of Montague, was an avid train enthusiast. Samuel Lococo, 96, of Northampton, was called "Poppy" by his eight grandchildren, with whom he liked to "play silly, made-up games." James Mandeville, 83, teased his daughter by stacking the deck when they played cards.
"He always made me feel like I was the most important person in the world," Mandeville's daughter, Laurie Mandeville Beaudette, wrote in his tribute.
The Holyoke Soldiers' Home Board of Trustees will hold its monthly meeting tonight. On the board's public agenda for discussion are plans for both a temporary and permanent memorial for COVID-19 casualties.
(c) 2020 MassLive.com
Distributed by Tribune Content Agency, LLC.


text:
Dr.-Ing. | Dipl.-Wirt.-Ing. | M. Sc.
The design of modern production and work environments – this is what drives and inspires us at GREAN. No solution is the same – and still, with a systematic approach, future-proof solutions for customer-specific challenges can be found.
Dr. Serjosha Wulf studied industrial engineering with a focus on mechanical engineering at the universities of Paderborn and Linköping (Sweden). Afterwards he worked as a research assistant at the Institute for Factory Systems and Logistics at the Leibniz University of Hanover and received his doctorate (Dr.-Ing.) in 2011. Since 2018 he has been a lecturer at the Leuphana University of Lüneburg on the subject of "Industrial Planning Procedures".
Special expertise in the areas of strategic plant development and master planning as well as factory planning and implementation. In addition, he is interested in topics such as new work, digitalization and the design of efficient and lean production and logistics processes. Project experience inter alia for the Sartorius Group, the Böllhoff Group, thyssenkrupp Steel Europe and ExxonMobil Production Germany. International project experience i.a. for the Sartorius Group in the UK and Finland and for thyssenkrupp Steel USA.
New construction on a greenfield site or expansion of existing buildings - we offer you comprehensive advice and sophisticated planning services for a well conceived factory. For us, this includes basic master and factory structure planning as well as support for your project right through to implementation. Whether new or reorganisation planning - we are experts in factory planning.
In many factories, high inventories, long travel, search or lead times are a major cost factor, which at the same time massively reduces production efficiency. This is what we do: Our customers benefit from well-founded, systematic and analytical consulting. In this way, we work with you to increase the efficiency of your production.
High and ever increasing material and energy costs are becoming an efficiency problem in many factories. We systematically investigate where potential is lying dormant and then identify meaningful and economical measures for improvement. In this way we increase the material and energy efficiency in your factory - and at the same time reduce your energy bill.
© 2021 GREAN GmbH. All rights reserved.


text:
This stunning and bold colorful tagua nut slices and rings woven bib has all the shades of green , from forest green, to lemon and teal interlaced with grays. It is one of my best sellers designs since 2018.
The idea down on me after watching the Broadway play Wicked and enjoying the use of the different shades of greens in the artist wardrobe when Glenda and Elfaba, the witch of the west visited the Emerald city. So if you are like Elfi or Elfaba, independent, free spirited and a fighter, this necklace is definitely the right one.
For spring and summer 2020 we have released new colors combos: pinks, berry & peach combo and also the blues or aqua combo also pictured.
Rainbow is also one of our best sellers in this unique bib necklace. Released in 2019 rainbow is the favorite between our customers.
The design is made of tagua nut slices, and hollow rings interpolated in a very unique array of contrasting colors and shapes. Adaptable length with pull leatherette or suede strings
5-7 business days
I'll do my best to meet these shipping estimates, but can't guarantee them. Actual delivery time will depend on the shipping method you choose.
Buyers are responsible for any customs and import taxes that may apply. I'm not responsible for delays due to customs.
Just contact me within: 7 days of delivery
Ship items back to me within: 14 days of delivery
Buyers are responsible for return shipping costs. If the item is not returned in its original condition, the buyer is responsible for any loss in value.
Organic Jewelry by Allie web site or shop has a Blog section giving you tips about how to take care of your tagua jewels.
Contact us trough our message center in ETSY for wholesale inquires


text: Home Surname List Name Index Sources Email Us | Jacob BOWLBY188,5443,5444,5552 was born on 28 June 1806 in Hunterdon Co., NJ.5444 He died on 28 March 1899 at the age of 92. He was buried in the old Valley Burying Ground, near Junction, later Hampton, Hunterdon Co., NJ.188 Jacob and his family appear in the 1850 census for Washington Township, Warren County, New Jersey. Parents: John "Uncle Jack" BOWLBY Sr.-40673 and Anna Catherine "Ann" WAGNER-122646. Spouse: Abigail "Abba" HIGGINS-122795. Abigail "Abba" HIGGINS and Jacob BOWLBY were married on 17 February 1831 in Hunterdon Co., NJ. Children were: James J. BOWLBY-122796, Elizabeth Ann BOWLBY-122797, Mary BOWLBY-122798, John BOWLBY-122799, William BOWLBY-122800, Morris BOWLBY-122801, Elisha BOWLBY-122802, Stewart BOWLBY-122803. Jacob BOWLBY188,5276 was born about 1830. Parents: Peter BOWLBY-122672 and Leah H. WELCH-122674. Jacob BOWLBY2585,5396 was born about 1859 in Ohio. Parents: Joseph BOWLBY-13232 and Mary WILLIAMSON-13233. Jacob A. BOWLBY1100,4215,4216,5278,5413 was born on 20 December 1824 in Somerset Co., PA. He was living in 1884. He died on 18 August 1907 at the age of 82. Parents: James A. BOWLBY-13527 and Sarah GROSS-13528. Spouse: Catherine A. BEALES/BAILS/BALES-33165. Catherine A. BEALES/BAILS/BALES and Jacob A. BOWLBY were married in 1846. Children were: Jahile/Jehiel/Jahiel C. BOWLBY-33168, Marietta E. "Mary" BOWLBY-33169, William King BOWLBY-33170, James Albert BOWLBY-33171, Francis M. "Frank" BOWLBY-33172, Dora Jane BOWLBY-33173, Emaline "Emma" BOWLBY-33176, John W. BOWLBY-33177, Elmer J. BOWLBY-33178. Jacob M. BOWLBY188,1026 was born on 19 January 1804 in Washington Twp., Warren Co., NJ.188 He died on 21 May 1864 at the age of 60 in Hunterdon Co., NJ.188 Parents: Thomas BOWLBY Jr.-40674 and Hannah (WIFE OF BOWLBY, THOMAS, JR.)-122354. Spouse: Effa WAGNER-122457. Effa WAGNER and Jacob M. BOWLBY were married. Children were: Lydia BOWLBY-122458, Hannah BOWLBY-122459, Emeline BOWLBY-122460, Henry S. BOWLBY-122461, Samuel BOWLBY-122462, Robert S. BOWLBY-122463, Mary BOWLBY-122464, John W. BOWLBY-122465, William L. BOWLBY-122936. Jacob McKinney BOWLBY188,189 was born in 1826 in Hunterdon Co., NJ. He died from angina pectoris on 27 April 1899 at the age of 73 in Ovid, Clinton Co., MI. He was buried at North Maple Grove Cem. in Ovid, Clinton Co., MI.189 Parents: George "Gage" BOWLBY-40678 and Anna CRISSMAN-123460. Spouse: Charlotte HALSTEAD-123513. Charlotte HALSTEAD and Jacob McKinney BOWLBY were married. Children were: Matilda BOWLBY-123514, Elmer A. BOWLBY-123515, Anna BOWLBY-123521, Charlotte "Lottie" BOWLBY-123522. Spouse: Elizabeth HALSTEAD-123523. Elizabeth HALSTEAD and Jacob McKinney BOWLBY were married. Jacob W. BOWLBY5388 was born in February 1863 in New Jersey. Parents: Robert M. BOWLBY-13707 and Anna J. MITCHELL-13708. Spouse: Arminty M. (WIFE OF BOWLBY, JACOB W.)-53631. Arminty M. (WIFE OF BOWLBY, JACOB W.) and Jacob W. BOWLBY were married. Children were: Robert M. BOWLBY-53381, Annie J. BOWLBY-53633, Mildred BOWLBY-53634. Living (private). Parents: Living and Beverly Anderson SOUTHALL-124580. Jahile/Jehiel/Jahiel C. BOWLBY1100,4213,4215,4216,5336 was born on 8 September 1848 in Pierceton, Kosciusko Co., IN.2590 He died on 26 November 1907 at the age of 59 in Pierceton, Kosciusko Co., IN.2590 He was buried on 29 November 1907 at Ryerson Cem. in Pierceton, Kosciusko Co., IN.2590 Parents: Jacob A. BOWLBY-13599 and Catherine A. BEALES/BAILS/BALES-33165. Spouse: Clara/Clarissa YOHN-41081. Clara/Clarissa YOHN and Jahile/Jehiel/Jahiel C. BOWLBY were married on 12 March 1874 in Kosciusko Co., IN.5553 James BOWLBY5225 was born (date unknown). Parents: James Artemus "Art" BOWLBY-122827 and Sadie M. PARKS-125169. James BOWLBY1240 was baptized on 30 July 1598 in Helmsley, North Riding, Yorkshire, England, UK. Parents: James BOWLBY-13057 and Anne THOMPSON-135411. James BOWLBY341 was born (date unknown). Parents: John BOWLBY III-40656 and Rachel SWAYZE-155091. James BOWLBY1238,1239,1240,1241 was born about 1567 in Helmsley, North Riding, Yorkshire, England, UK.1242 He signed a will on 28 February 1607/8.1242 His will was proven at York on 21 DEC 1608/1609. He died before 2 March 1608 at the age of 41.1242 James was buried on 2 March 1607/8 in Helmsley, North Riding, Yorkshire, England, UK.1240,1242 Parents: John BOWLBY-13048 and Elizabeth (WIFE OF BOWLBY, JOHN)-13049. Spouse: Anne THOMPSON-135411. Anne THOMPSON and James BOWLBY were married on 20 January 1589/90 in Helmsley, North Riding, Yorkshire, England, UK. Children were: Elizabeth BOWLBY-135412, John BOWLBY-135414, Anne BOWLBY-135415, James BOWLBY-135416, Thomas BOWLBY-135417, Jane BOWLBY-135418, Anne BOWLBY-135420. James BOWLBY Sr.1245,1246,3482,5350,5554 was born on 27 September 1765 in near Mansfield, Sussex Co., NJ.1246,5555 He died on 28 May 1842 at the age of 76 in Monongalia Co., VA, now WV.1246 Parents: John BOWLBY Jr.-13085 and Catharine/Katherine HORNBAKER-40655. Spouse: Lydia CARHART-75215. Lydia CARHART and James BOWLBY Sr. were married in 1787 in Mansfield, Sussex Co., NJ. Children were: Samuel Coleman BOWLBY-75218, Rebecca BOWLBY-75219, Williampe Carhart BOWLBY-75220, Robert Lanning BOWLBY-75217, John Harold/Herod BOWLBY-75221, Catherine/Catharine "Catey, Caty" BOWLBY-75222, James BOWLBY Jr.-135154. James BOWLBY1244,5265,5556 was born on 2 March 1779 or 21 March 1779.5556 He died on 14 September 1862 at the age of 83 in Bath, Steuben Co., NY.5556,5557 He was buried at Grove Cem. in Bath, Steuben Co., NY.4969,5265 Parents: Richard BOWLBY Sr.-13082 and Mary DRAKE-40905. Spouse: Catherine MAYBURY-41106. Catherine MAYBURY and James BOWLBY were married on 8 February 1807 in Sussex Co., NJ.1246,5558 Children were: Mary BOWLBY-41107, Sophia BOWLBY-41108, Eliza Ann BOWLBY-41109, Marllau or Matthew BOWLBY-41110, Sarah N. BOWLBY-41111, Nancy Amelia BOWLBY-41112, Catherine Alceste BOWLBY-41113, Kitturah Desdemona BOWLBY-41114, James Newbold Woolston BOWLBY-41115, John Alverman BOWLBY-41116. James BOWLBY Jr.693 was born on 6 November 1803 in Monongalia Co., VA, now WV. He died on 29 April 1823 at the age of 19. Parents: James BOWLBY Sr.-40658 and Lydia CARHART-75215. James BOWLBY4331,5399,5528 was born about 1818.1614 He lived in Lebanon, Hunterdon Co., NJ in 1839.5238 Parents: John S. BOWLBY-13631 and Elizabeth MILLER-13633. Spouse: Sarah SMITH-14752. Sarah SMITH and James BOWLBY were married on 27 June 1839 or 29 June 1839.1614,5238 They1614,5238 were married by Rev. T. Barrass5238 Children were: Julia Ann BOWLBY-91160, Harriet Isabel BOWLBY-14750, Noah BOWLBY-91166, Reeder BOWLBY-91167, James BOWLBY-91168, Rachel Bethier BOWLBY-91169. James BOWLBY801,1428 was born on 26 July 1824.1428 Parents: Robert Lanning BOWLBY-75217 and Margaret SMITH-75223. Spouse: Nancy EVANS-134042. Nancy EVANS and James BOWLBY were married in 1848. Children were: Emiline BOWLBY-134044, Martha BOWLBY-134045. Spouse: Anna V. POOLE-134043. Anna V. POOLE and James BOWLBY were married on 24 December 1857. Children were: Cora W. BOWLBY-134046, Jennie E. BOWLBY-134048, Laura Augusta BOWLBY-134049, Theophilus Poole BOWLBY-134050. Squire James BOWLBY1100,4594,5278,5286,5559 was born on 8 December 1831 in Wayne Co., OH.1552 He was also known as James A. BOWLBY.1552 He appeared in the census in 1880 in Ridge Twp., Wyandot Co., OH.5281 1880 Census Ridge, Wyandot Co,OH NA film # T9-1079 James died from uremic poisoning on 27 January 1913 at the age of 81 in Carey, Crawford Twp., Wyandot Co., OH.5560 Obituary, Daily Chief Jan 27, 1913: I have acquired a death certificate (#6300) for James Bowlby from the Ohio Historical Society. Most of the info transcribed below: He was buried on 29 January 1913 at Lutheran Ridge Cem. in Ridge Twp., Wyandot Co., OH.5561 He was a Justice of the Peace. He moved to Wyandot Co., OH in 1852. He purchased a saw mill west of Carey which was destroyed by fire twice at eight year intervals. After rebuilding the second time, he sold the mill, moved to Carey, and became foreman for Watson & Company in their saw mill department. Parents: James A. BOWLBY-13527 and Sarah GROSS-13528. Spouse: Amanda R. GRINDLE-13603. Amanda R. GRINDLE and Squire James BOWLBY were married on 1 January 1857.1552 Children were: Ellen BOWLBY-13604, Emma L. BOWLBY-13605, Alice A. BOWLBY-13606, Hattie BOWLBY-13607, Roland DeVere BOWLBY-13608, Orville C. BOWLBY-13609, Noland H. BOWLBY-13610, Violetta A. BOWLBY-55946, Alfred Barton BOWLBY-13611, Joseph Weldon BOWLBY-13612, Bert BOWLBY-56007. James BOWLBY155,1244,3841 was born on 24 July 1835 in Clement, Nova Scotia, Canada.5562 He died on 1 July 1918 at the age of 82 in Herscher, Kankakee Co., IL.5562 He was buried at Pilot Cem. in Herscher, Kankakee Co., IL.3841,5562 James immigrated to the United States in 1855, and located in Kankakee Co., where he purchased unimproved land in Norton and Pilot Townships, and farmed until 1880. He moved to Herscher where he built a business house and was a merchant for ten years. In 1889 he engaged in the hotel business and was a hotel keeper until the fall of1892. His biography appears in PORTRAIT AND BIOGRAPHICAL RECORD OF KANKAKEE COUNTY ILLINOIS, 1893. Parents: George BOWLBY Jr.-40969 and Sarah DEWITT-41171. Spouse: Mary Jane BARBER-41187. Mary Jane BARBER and James BOWLBY were married on 3 December 1860 in Kankakee Co., IL.3841,3842 Children were: Charles William BOWLBY-147371, Norman Lindley BOWLBY-147374, Elmer Harris BOWLBY-147381, Rhoda Clara BOWLBY-147413. James BOWLBY1614 was born about 1850 in New Jersey. Parents: James BOWLBY-14751 and Sarah SMITH-14752. James BOWLBY5290,5291,5375 was born on 11 January 1868 in Stark, Stark Co., OH. Parents: Emanuel BOWLBY-13531 and Sarah STAHL/STALL-170168. Spouse: Lillian Elsie "Lilly or Lillie" KRICHBAUM-57231. Lillian Elsie "Lilly or Lillie" KRICHBAUM and James BOWLBY were married on 31 December 1892. Children were: James Emanuel BOWLBY-57235, (Child of Lillian Elsie and James BOWLBY) BOWLBY-57234, Clara BOWLBY-57233. Living (private). Parents: James Orlando BOWLBY-91676 and (Wife of BOWLBY, James Orlando) -125180. James A. BOWLBY4164,5103,5563,5564 was born on 11 September 1796 in Hunterdon Co., NJ. He died from apoplexy, after falling in the Necada Depot, Wyandot Co., OH on 22 November 1870 or 23 November 1870 at the age of 74 in Crawford Co., OH.5563 From Mrs. Randi K. Webber, Deputy Clerk Crawford Co.: Be advised that I have checked the death records, but find nothing for the above mentioned parties. The early death records were kept by the tax assessors; therefore they are incomplete. (Death records do not begin until 1867.) ***** The census of 1820 of Milford Twp., Somerset Co., PA. lists a "BOWLSPREY, James" as a family of four: 1 male between 15-26; 1 female between 16-26; 1 male under 10; and 1 female under 10. James BOWLBY and wife, Sarah, were in Somerset Co. 15 MAR 1828, when they disposed of two parts of his grandfather's estate, one part having been released to him previously by his brother, Henry BOWLBY. James and Sarah moved from PA. to OH. in 1831. They raised most of their family in Stark Co., then in 1852 moved to Crawford Co., and lived somewhere near Galion and Bucyrus, both are given as their address. They are said to have had 14 children, 13 of whom they raised to maturity, one died as an infant. Nine of the 13 children were living in 1884. Mrs. Cordelia KELLY writes: "We do not know James' wife's maiden name but they called her Aunt Sarah. Her weight was 300 and James had a carriage made for her and a ladder to get in and out of the carriage. My father and his brother, Samuel CARBAUGH, visited them in 1849." Later Mrs. KELLY gives Sarah's last name as "GROOSE". Her companion in family research, Mrs. GRIZZELLE, gives Sarah's last name as "CROSS". Spouse: Sarah GROSS-13528. Sarah GROSS and James A. BOWLBY4164 were married in Somerset Co., PA. The census of 1820 of Milford Twp., Somerset Co., PA. lists a "BOWLSPREY, James" as a family of four: 1 male between 15-26; 1 female between 16-26; 1 male under 10; and 1 female under 10. James BOWLBY and wife, Sarah, were in Somerset Co. 15 MAR 1828, when they disposed of two parts of his grandfather's estate, one part having been released to him previously by his brother, Henry BOWLBY. James and Sarah moved from PA. to OH. in 1831. They raised most of their family in Stark Co., then in 1852 moved to Crawford Co., and lived somewhere near Galion and Bucyrus, both are given as their address. They are said to have had 14 children, 13 of whom they raised to maturity, one died as an infant. Nine of the 13 children were living in 1884. Mrs. Cordelia KELLY writes: "We do not know James' wife's maiden name but they called her Aunt Sarah. Her weight was 300 and James had a carriage made for her and a ladder to get in and out of the carriage. My father and his brother, Samuel CARBAUGH, visited them in 1849." Later Mrs. KELLY gives Sarah's last name as "GROOSE". Her companion in family research, Mrs. GRIZZELLE, gives Sarah's last name as "CROSS". THE HISTORY OF WYANDOT COUNTY, OHIO, published by Legett, Conaway & Company, in 1884, gives three biographies of members of this family. Children were: Joseph BOWLBY-13529, Rachel BOWLBY-13530, Emanuel BOWLBY-13531, John BOWLBY-13580, Jacob A. BOWLBY-13599, Hannah BOWLBY-13600, Elizabeth BOWLBY-13615, Maria/Mariah BOWLBY-13601, Squire James BOWLBY-13602, Mary Jane BOWLBY-13613, Catharine BOWLBY-13616, Samuel BOWLBY-13614, Sarah BOWLBY-13617. James A. or L. BOWLBY5103,5295 was born in 1843 in Ohio. Parents: Joseph BOWLBY-13529 and Elizabeth Catharine TEEPLE-40643. James Albert BOWLBY1100,4215,5413 was born on 17 April 1856 in Hancock Co., OH.5566 He was also known as Albert J..5566 He died on 22 May 1937 at the age of 81.5566 James was buried at Salem Cem. in Noble Co., IN.5566 Parents: Jacob A. BOWLBY-13599 and Catherine A. BEALES/BAILS/BALES-33165. Spouse: Zillah BENTON-155090. Zillah BENTON and James Albert BOWLBY were married in 1875. Children were: Nora BOWLBY-156353. James Artemus "Art" BOWLBY188,5225,5567 was born on 17 December 1882. He died on 24 November 1951 at the age of 68 in Lambertville, Hunterdon Co., NJ. He was buried at Musconetcong Valley Cem. in Hampton, Hunterdon Co., NJ. Parents: David B. BOWLBY-122814 and Mary Jane CASE-122815. Spouse: Sadie M. PARKS-125169. Sadie M. PARKS and James Artemus "Art" BOWLBY were married. Children were: David BOWLBY-125170, James BOWLBY-125179. Living (private).5314 Parents: Arthur Francis BOWLBY-34807 and Mildred Arlene MCLOUD-34808. Spouse: Living. Children were: Living, Living, Living. James B. BOWLBY190 was born (date unknown). Parents: James P. BOWLBY-134460 and Irene BOYLES-134461. Spouse: (Wife of BOWLBY, James B.) -134471. (Wife of BOWLBY, James B.) and James B. BOWLBY were married. Children were: Bessie L. BOWLBY-134472. James B. BOWLBY188,2687,2760,2761,2762,2763 was born on 1 August 1825 in Ohio. He was a cooper in Dayton, Montgomery Co., OH. Parents: David BOWLBY-40681 and Catharine Elizabeth BEATY-74245. Spouse: Susan Malinda AGENBROAD-74247. Susan Malinda AGENBROAD and James B. BOWLBY were married in 1845. Children were: Thomas BOWLBY-74248, Elizabeth BOWLBY-148075, Nathan J. BOWLBY-148076, Martha BOWLBY-148576. James Bradford BOWLBY5249 was born on 21 September 1850 in Bear River, Nova Scotia, Canada. He died about 1939 at the age of 89. Parents: William Barnaby BOWLBY-147172 and Rebecca Maria VAN BOEHLER-147173. Spouse: Frances Isabella CHAPMAN-147175. Frances Isabella CHAPMAN and James Bradford BOWLBY were married on 13 May 1874. Children were: Lillian May BOWLBY-147186, Chester Elmor BOWLBY-147188, Elnora Etta BOWLBY-147190, Zedeska Louvell "Dick" BOWLBY-147192, Rebecca Ellen BOWLBY-147196, Ada Amanda BOWLBY-147198, Eva Grace BOWLBY-147200, Hilda Iona BOWLBY-147202, Elsie Ora BOWLBY-147203, William Sidney BOWLBY-147205. James E. BOWLBY1827 was born on 20 February 1863. Parents: Henry Jackson BOWLBY-13261 and Sarah BOWLBY-13260. James Edward BOWLBY486 was born on 13 August 1862. He died on 3 June 1936 at the age of 73. Parents: George Freeman Allen BOWLBY-41184 and Clarissa MCMEAHEN-41185. Spouse: Elizabeth BUTLER-147350. Elizabeth BUTLER and James Edward BOWLBY were married. Children were: Norman Allen BOWLBY-147353. James Edward BOWLBY338,5361 was born on 13 April 1882. He died on 24 January 1963 at the age of 80. He was buried at Nondaga Cem. in Bath, Steuben Co., NY.5568 Parents: George King BOWLBY-47495 and Sarah Elizabeth HARDENBROOK-47496. James Emanuel BOWLBY5569 was born about 17 May 1890 in Antrim Twp., Wyandot Co., OH. He died from cholera on 12 August 1892 at the age of 2 in Antrim Twp., Wyandot Co., OH. Parents: James BOWLBY-13572 and Lillian Elsie "Lilly or Lillie" KRICHBAUM-57231. Living (private). Parents: James Fitzgerald BOWLBY-125333 and Alberta Grace LIKEFIELD-125334. James Fitzgerald BOWLBY5389 was born on 19 July 1928. Parents: Robert Oswald BOWLBY-125241 and Christine Margot LEONARD-125242. Spouse: Alberta Grace LIKEFIELD-125334. Alberta Grace LIKEFIELD and James Fitzgerald BOWLBY were married in July 1949. Children were: Living, Living, Living. James Franklin BOWLBY188,3140 was born on 24 November 1859 in Tipton Co., IN. He died in 1925 at the age of 66 in Tipton Co., IN. He was buried at Sharpsville Cem. in Sharpsville, Tipton Co., IN.188,3140 Parents: William BOWLBY-123621 and Rebecca Jane LINDSAY-123622. Spouse: Viola Jane KELLY-123635. Viola Jane KELLY and James Franklin BOWLBY were married on 15 February 1880 at East Hopewell Presbyterian Church in Tipton Co., IN. Children were: Viola BOWLBY-123636. Spouse: Mary Elizabeth HORTON-123637. Mary Elizabeth HORTON and James Franklin BOWLBY were married on 20 August 1885. Children were: Rebecca Ellen Horton "Ella" BOWLBY-123638. James Franklin BOWLBY5570 was born on 1 October 1923 in Clallam Bay, Clallam Co., WA. He served in the military in the U. S. Navy between 17 September 1941 and 13 November 1946. He served in the military in the U. S. Air Force between 28 August 1950 and 17 August 1951. Parents: William Henderson BOWLBY-123650 and Beatrice May SANDS-129481. Spouse: Zada Alene ROBERTS-129522. Zada Alene ROBERTS and James Franklin BOWLBY were married on 16 March 1946. Children were: Living, Living. James H. BOWLBY4934 was born on 8 April 1814. He died on 5 January 1892 at the age of 77 in Metropolis, Massac Co., IL. He was buried at Hallaway Cem. in Murphysboro, Jackson Co., IL. Parents: Samuel Barker BOWLBY-13026 and Hulda MESSENE/MESZENE-13027. Spouse: Mary Lelia MORGAN-13235. Mary Lelia MORGAN and James H. BOWLBY were married. James H. BOWLBY3839 was born about 1857 in Murphysboro, Jackson Co., IL.5537 Parents: Henry Clay BOWLBY-13251 and Angeline WARD-13256. James Harold BOWLBY4525 was born (date unknown). He died as an infant. Parents: Harold Burton BOWLBY-146984 and LaVaughn Frances Willard WOODWORTH-146985. James Hervey BOWLBY2574,5362 was born on 6 August 1865 in Indianapolis, Marion Co., IN.2574 He died on 26 May 1953 at the age of 87 in Parsons, Labette Co., KS.2574 He was buried in Savonburg, Allen Co., KS.5571 James was also known as Harvey.5571 Parents: Elisha Hess "Hurst" BOWLBY-13903 and Elisa/Eliza Jane ANDERSON-15149. Spouse: Martha A. PRICE-36867. Martha A. PRICE and James Hervey BOWLBY were married on 6 March 1886 in Wichita, Sedgwick Co., KS.5571 Children were: Martha Edna BOWLBY-36868. Spouse: Lula Maria DANIELS-36869. Lula Maria DANIELS and James Hervey BOWLBY were married on 28 February 1889 in Savonburg, Allen Co., KS.5571 Children were: Albert Daniel BOWLBY-91662, Elsie Ellen BOWLBY-91701, Ernest Hervey BOWLBY-91728, Alice Lula BOWLBY-91753, Leonard Harley BOWLBY-91754, Nellie Gertrude BOWLBY-91772, Alta Marie BOWLBY-91820, Robert William BOWLBY-36870. James Hubbard BOWLBY338 was born in Steuben Co., NY. He died in Savon, Steuben Co., NY. Parents: James Newbold Woolston BOWLBY-41115 and Emily Aubert KING-47494. James I. BOWLBY188,5572 was born in 1851. He died in 1931 at the age of 80. He was buried at Musconetcong Valley Cem. in Hampton, Hunterdon Co., NJ. Parents: George W. BOWLBY-123270 and Sirena LINCOLN-123275. James J. BOWLBY188,5443 was born about 1831 in Hampton, Hunterdon Co., NJ.5444 Parents: Jacob BOWLBY-122794 and Abigail "Abba" HIGGINS-122795. James Keith BOWLBY5411 was born on 30 August 1941. He graduated in 1959 from Galion High School, Crawford Co., OH. He died on 23 April 2010 at the age of 68 in rural Bucyrus, Crawford Co., OH. James was cremated. He was buried at Brokensword Cem. in Bucyrus, Crawford Co., OH.5411 He was a member of the Evangelical Pietist Church in Bucyrus, Crawford Co., OH. Parents: Donald Eugene BOWLBY-68339 and Lucille HOLTSHOUSE-68340. Spouse: Living. James Llewelyn BOWLBY5254 was born on 2 March 1899 in Paradise, Nova Scotia, Canada. He is the twin brother of William Lawrence BOWLBY He died on 12 January 1957 at the age of 57. Parents: Burton Francis BOWLBY-146978 and Annie Laurie FOSTER-146979. James Newbold Woolston BOWLBY338,1244 was born on 25 October 1826 in Dryden, Tompkins Co., NY.1246 He was also known as James Newbold Wilson BOWLBY.1246 He died on 20 October 1910 at the age of 83.5510 James was buried at Nondaga Cem. in Bath, Steuben Co., NY.5510 Parents: James BOWLBY-41105 and Catherine MAYBURY-41106. Spouse: Emily Aubert KING-47494. Emily Aubert KING and James Newbold Woolston BOWLBY were married on 22 February 1853.5361 They lived almost their entire life on the BOWLBY farm in Babcock. Children were: George King BOWLBY-47495, James Hubbard BOWLBY-147826. James Orlando BOWLBY1689 was born on 23 October 1913 in Omaha, Douglas Co., NE. Parents: Albert Daniel BOWLBY-91662 and Nancy E. MILLER-91663. Spouse: (Wife of BOWLBY, James Orlando) -125180. (Wife of BOWLBY, James Orlando) and James Orlando BOWLBY were married. Children were: Living, Living. |


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Nurses are multi-skilled professionals that rely on a breadth of knowledge and experience to perform their jobs effectively. The demanding position requires them to have a range of both hard and soft skills, along with certain personality traits that help them succeed.
Understanding which skills nurses possess can help you develop the necessary skill set to excel in your own nursing career. In this article, we explore some of the most important skills for nurses to help you understand what it takes to do the job effectively.
Top 11 skills for aspiring nurses to develop
Regardless of where you are in your nursing journey, whether you're in the process of doing an RN to BSN online or you're already a fully qualified nurse, understanding the most important skills in nursing can help you improve and advance your career. Here are some of the most important skills these professionals rely on:
Being a team player and knowing how and when to support your colleagues is an essential skill for nurses, as smooth-running clinical environments depend on effective cooperation. Relying on your team for support and advice also helps you make correct decisions under pressure, as nurses often find themselves in stressful and time-sensitive situations. Offering emotional support to your colleagues also helps you establish support networks that you can also rely on, as it's important to maintain your mental, emotional and physical wellbeing. Working well with others also helps you deliver the best possible care to patients and ensure care continuity.
Nurses frequently have to evaluate situations and decide what's best for their patients, weighing up the various factors and proceeding intelligently. Critical thinking is essential for effective decision making, problem solving and learning new skills and information. To ensure the best possible outcomes, nurses need to think logically and consider all variables in front of them, as ineffective thinking can lead to mistakes. The five pillars of critical thinking for nurses are problem recognition, prioritization, clinical decision making, clinical implementation and reflection. Be sure to write things down and closely analyze situations to develop your critical thinking.
Empathy is another vital skill in nursing, as it helps you understand not only the thoughts and feelings of your patients, but also those of your colleagues and your patients' families. This can help you tailor your actions towards what's best for the emotional wellbeing of those around you, leading to more effective and compassionate care provision. Empathy can also help you identify your patients' needs, as they might not always be able to communicate them for various reasons. Placing yourself into the shoes of others can help you identify with their suffering and make decisions that benefit them.
As recent events have emphasized, nurses can get seriously busy at times, so being an effective multitasker is a valuable skill. Nurses often deal with several patients at once and it's necessary for them to be able to handle multiple tasks simultaneously. Being able to multitask also increases the speed and efficiency of caregiving, enabling you to help more people in a given day. If you execute several tasks simultaneously in an organized way, you can maintain high quality standards while also boosting your productivity. This is often a requirement for nurses, who rely on multitasking skills to deliver care.
This is one personality trait and skill that nurses can't do without, as establishing trusting relationships with patients requires a sound moral compass and honesty. Nurses with integrity can encourage people to open up to them about their thoughts and feelings, as patients can trust that the information is in safe hands. It's also important for patients to express themselves openly and honestly to nurses, as this helps guide care decisions. Because nurses are in positions of authority and they witness things that are highly sensitive to people, integrity is an absolutely essential quality.
Nurses also need integrity because they have a lot of important responsibilities, and it's essential for them to be accountable for their actions for the good of those in their care. For example, if a nurse makes an error, or their colleague makes an error in front of them, this needs to be reported so the proper corrective actions can take place. Even a small mistake, such as incorrectly filing documents, can have drastic repercussions, because it may affect a patient's continuity of care. This means nurses must have integrity and be honest in such circumstances.
Nurses often act as leaders, and when they lead effectively, they can deliver better outcomes for patients. This is because stronger, better organized teams achieve greater outcomes in terms of safety and quality, and overcome challenges much more easily. When assuming leadership roles, nurse leaders inspire, motivate and support their peers, offering high-quality feedback and promoting ongoing improvement. As such, it's important for nurses and aspiring nurses to develop their charisma, rapport-building abilities and public speaking skills, as these all enable you to lead effectively. Forming good relationships with your colleagues and being able to delegate effectively are also traits of a good leader.
Attentiveness is a valuable skill in nursing, as nurses must be aware of their patient's needs at all times. When looking after multiple people simultaneously, this is especially important, because you might miss something important if you're focusing disproportionately on one person. Spreading your attention out equally amongst patients is essential to ensure the best outcomes. Attentiveness is also vital when communicating with patients, as small details can often give away important facts. Being attentive to body language, for example, may help you extract deeper meaning when discussing things with patients.
Nursing involves interacting with people constantly, including organizational leaders, other healthcare professionals and patients. As such, it's vital to be an effective communicator and have great interpersonal skills. Nurse practitioners communicate in various ways, and the job requires them to have strong writing, speaking and listening skills. Effective communication in all these areas is imperative, as miscommunications can lead to serious problems, such as patients being confused about how to follow treatment plans or other staff receiving unclear directions.
Being a competent practitioner is an obvious skill, but it can't be neglected, even as the years go by. There's always more to learn in this field and always areas in which you can prove, so be sure to maintain your competence in all relevant areas. Once you are entirely competent in your respective area, you can more confidently practice independently. Overestimating your competence can put patients at risk, so it's important to be realistic and highly self aware. Never practice outside your realm of expertise, as it's essential to be fully trained and experienced before attempting new things.
You can develop your competencies in various ways, such as by attending courses and completing certification programs in relevant areas, or by shadowing more senior employees. Always ask questions if you're uncertain, and constantly develop your knowledge through self study and research. Many organizations also host seminars and conferences for nurse practitioners, and these are certainly worth attending.
Nurse practitioners are busy people and the demands placed on them are increasing constantly. For these reasons, knowing how to manage your time effectively so you can dedicate it to people fairly is crucial. The way you manage your time can directly impact the experiences of patients, as they may have to wait unnecessarily if you don't complete tasks with acceptable windows. This is not to say that nurse practitioners should rush however, but it's crucial for them to use the time they spend with patients wisely. Learning how to control conversations to avoid digression is a good time-management skill.
Diagnosing illnesses and prescribing effective treatments can be viewed as a form of complex problem solving, so it's great for nurses to have advanced analytical skills. This helps them analyze the evidence they have and make sensible conclusions for the betterment of their patients. Nurses must gather and analyze complex data, solve problems and make intelligent decisions. Having such skills helps nurses treat patients not only quickly, but effectively, and both are essential for helping patients in the best possible way. Being analytical means challenging assumptions, asking questions, considering potential outcomes, exercising critical thinking skills and making evidence-based decisions.


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Are you looking for a practical umbrella base for your outdoor time? This modern and concise heavy-duty umbrella base is suitable for various outdoor places, such as the backyard, patio, poolside, and so on.
- Excellent Material and Stability: Delicately crafted with high-quality heavy-duty steel, this patio umbrella base features great durability to ensure long-term service life. The powder-coated surface is rustproof and corrosion-resistant. Besides, the square base increases the contact area with the ground for added stability.
- Hand Tightening Knob: The umbrella base is designed with a hand-turn knob, which provides secure fastening for the position of the umbrella pole even on windy days. You can turn it one way to tighten it into place and the opposite way to loosen it, which is easy to operate saving your time and energy.
- Suitable for Most Umbrellas: Equipped with 3 plastic adapters of 1.4'', 1.5'', and 1.9'' diameter, this multifunctional umbrella base matches well with most market umbrellas of different sizes and brands. In addition, this versatile umbrella base can be used in both commercial and residential use.
- Modern and Practical Design: With a thickness of less than 1'', this umbrella base stand is perfect for an outdoor patio table with an umbrella hole while remaining enough foot space under the table. Featuring a stylish and concise appearance, this umbrella base with a flat design will add more glamour to your outdoor space.
- Wide Application and Simple Assembly: This multi-function umbrella base stand is perfect for various umbrellas, which allows you to enjoy leisure time with your family and friends while out of harmful sun rays. It is perfectly suitable for outdoors, patios, balconies, poolside, backyard, and so on. What's more, with clear instructions and all the parts required, you can finish the installation in a short time.
- Color: Black
- Material: Steel & Plastic
- Product Dimension: 25''x25''x15'' (L x W x H)
- Pole Dimension: 14''x2.4'' (H x D)
- Pole Holder Size: 1.4'', 1.5'', 1.9''
- Net Weight: 40 lbs
Package Includes
- 1 x Square Umbrella Base
- 3 x Adapters
- 1 x Instructions


text: 14 miles east of Pereira can visit the Otún Quimbaya Flora and Fauna Sanctuary, a protected area of 489 hectares characterized by rainforest vegetation and sub-Andean forest. This place, where there are 259 species of flora (including oak, cherry and romerón), is ideal for bird watching and butterflies. There cane skunks, tapir and other animals inhabit the zone.


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Proud Dad Curt Schilling 'Sons' Twitter Trolls; Could Charges Follow?
You mess with the bull, you get the horns. Some Twitter trolls messed with proud papa Curt Schilling after he tweeted congratulations to his daughter her acceptance to college.
Schilling responded by tracking down and exposing a few choice commenters, one of whom has already been fired, and may follow up by pursuing criminal charges or a civil lawsuit.
Sweet Tweet, Sour Responses
Last week, Schilling congratulated his daughter Gabby on her acceptance to Salve Regina University and her future collegiate softball career:
Congrats to Gabby Schilling who will pitch for the Salve Regina Seahawks next year!!
-- Curt Schilling (@gehrig38) February 25, 2015
Pretty standard for proud fathers on social media. But as we've all learned by now, the Internet has the unique ability to make anything, even a harmless dad tweet, into a feeding frenzy for twits.
Many of the responses to Schilling's tweet were more vile than we'd like to post here, but if you'd like to peruse some of the more disgusting lowlights you can find them on the former pitcher's blog.
Schilling Smack-Down
Schilling had apparently had enough of the sex and rape references and decided to single out two of the more repugnant responders. And, according to NJ.com, one has already been fired from his recently acquired job selling tickets for the New York Yankees. Both of the outed harassers' Twitter accounts have since been deleted, along with others that Schilling highlighted.
And Schilling is hinting that there may be more consequences for trolls. The retired pitcher called the tweets "a crime," promised to "pursue all legal options," and said he had already been contacted by local law enforcement and the FBI.
Are Idiots Illegal?
So what charges could Schilling be talking to the cops about? While your average comment section clash isn't criminal, online activity can become harassment if it is intended to alarm, annoy, torment, or terrorize another party. Many states have also enacted strict cyber bullying laws outlawing online targeting and bullying.
While these are state statutes, when harassment crosses state lines (as the Internet is wont to do) the feds can get involved, which may explain Schilling's conversation with the FBI.
Schilling may also have some recourse in civil court. Suits for online defamation are becoming more and more common as Internet trolling incidents increase.
It is unclear where Schilling's case will go, but the lesson is clear -- don't make bomb threats on Twitter, don't make death threats on Twitter, and maybe don't make daughter jokes to a dad on Twitter either.
Follow FindLaw for Consumers on Facebook and Twitter (@FindLawConsumer).
Related Resources:
- Curt Schilling takes action against daughter's online bullies (CBS News)
- Man Arrested for Post-Zimmerman Facebook 'Threat' (FindLaw's Blotter)
- Twitter Threats Can Lead to Restraining Orders (FindLaw's Blotter)
- Are You an Internet 'Troll'? Legal Consequences to Consider (FindLaw's Law and Daily Life)


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Heinz Mutant Turtles Snap Pots Pasta Shapes 2 X190g
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Heinz Pasta Shapes
Heinz has a range of pasta shapes which appeal to younger children. Licences include kids' favourites Peppa Pig and Minions. We keep our licensed range of pasta shapes fresh and exciting to keep mealtimes fun and engaging; you may have seen our latest new shapes including Scooby Doo and DC Super Friends.
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Without a coherent structure to your writing, the piece will be difficult to follow w. Know that I really struggled with this at the beginning of the year. My essays were jumble d and the members of my writing group often told me that needed to focus more on keeping my information in order. For example, after reading the book petty by Ben Mislabels we were asked to pick any essay form we wanted and write about something that stuck with us. My essay y was about not judging a book by its cover, and how most people saw Petty as nothing but a n idiot. Undo it very difficult to keep the focus on my thesis, and it showed in my writing, With help from the corrections made by my peers and my teacher, I can score perfect on organize action in my essays. Another concept of writing that I struggled with was word choice. This is just a important in an essay as organization, and can make or break your entire sass moment. When I look back on my writing I don't really think I have actually improved on word choice, but now it is something that I can focus on and try to do better with in my future writing g.
My final improvement this year has been the consideration towards my audio once. While I never really notice a point system for this concept in the grading rubrics, I can tell simply by going over my essays from this year that there has been significant change. At the beginning of the year, I was stuck in the mindset that what I write is mine, and if people do NT like it they can read something else. This isn't the best way to think though, and no matter w hat I end up writing in life it will always be for a specific audience, and I need to take careful cons duration in how rite for that specific audience.
Reading our essays outlook to our writing grog ups has really helped me learn this, and I now find myself constantly asking myself "who am writing this for? " While I am nowhere near a "professional" writer, feel like this course has Greg tally improved my skills In more ways than one. Coming back from summer break was rusty and my writing was jagged incoherent. With the vigorous writing assignments I have if noshed, I can now confidently say that my organization, word choice, and attention to whom my audience is has increased greatly, and will benefit my writing from now on.


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Surgeon perception is not a good predictive indicator of intraoperative performance and subsequent functional outcome in robot-assisted radical prostatectomy.
Munich, Germany-Surgeon perception is not a good predictive indicator of intraoperative performance and subsequent functional outcome in robot-assisted radical prostatectomy, say researchers from the University of Pennsylvania, Philadelphia.
That conclusion was based on a study of 39 consecutive patients in which a single experienced surgeon used a scoring sheet to prospectively capture his subjective opinion of how well individual elements of the robot-assisted procedure were completed. In a number of cases, patients with "bad" perceived results did well in terms of postoperative continence when compared with patients whose procedures were graded as "good."
"Continence recovery after robotic prostatectomy is a complex mechanism," said senior author David Lee, MD, assistant professor of surgery/urology at the University of Pennsylvania. "No one factor or nuance makes a large difference in continence results.
The study came about, Dr. Lee said, because he and his team "have found it frustrating that some patients do very well and others not so well early on after the robotic prostatectomy operation. I do about 10 to 12 prostates per week and have done more than 2,000 in my career, and I still can't accurately predict, based on intraoperative factors, who will do well continence-wise after the operation."
Dr. Lee performed the procedures and graded his work as "good," "average," or "bad" in each of seven intraoperative factors:
Of the 273 recorded responses (39 patients multiplied by seven variables), 59% were "good," 32.5% were "average," and 8.5% were "bad." There were no significant differences among the variables in reaching zero or one pad per day (p>.05) at both the 1- and 3-month time points.
"We did this study to see if there would be any particular factor that might lead to better early continence outcomes," Dr. Lee noted. "And patients who had a very good bladder neck-sparing operation did seem to have a slightly quicker continence recovery.
"But all in all, while we had hoped for something more definitive, we're not really surprised by the results."
'Bad' grades may mean good outcomes
Patients whose results were graded as "bad" in some variable outcomes did, in fact, have quicker continence recoveries, with a median time to reach social continence of 7 weeks versus 10 weeks for those patients whose results were graded as "good."
The authors noted that while surgeons "have always used their cognitive intuitive skills for execution of skilled tasks and real-time perception of the intraoperative outcomes," inter-surgeon perception can vary and may therefore warrant further investigation as it relates to functional outcomes.


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In this lesson, you will consider two ideas that seem to contradict.
Firstly, there's the belief clearly taught in scripture, that God is a just and righteous Judge who will punish sinners.
Secondly, there's the belief taught in certain creeds, that sinners are what they are by God's decree, and cannot change themselves.
The creeds seem to contradict the scriptures. How can God be a just and righteous judge, yet condemn and punish people for being as he unchangeably made them?
The scriptures clearly represent God as a righteous judge who is always just and fair.
The creeds agree entirely with this. Notice how the Westminster Confession, like the Bible, attributes justice and mercy to God...
"There is but one only, living, and true God, who is infinite in being and perfection, a most pure spirit, invisible, without body, parts, or passions; immutable, immense, eternal, incomprehensible, almighty, most wise, most holy, most free, most absolute; working all things according to the counsel of his own immutable and most righteous will, for his own glory; most loving gracious, merciful, long-suffering, abundant in goodness and truth, forgiving iniquity, transgression, and sin; the rewarder of them that diligently seek him; and withal, most just, and terrible in his judgments, hating all sin, and who will by no means clear the guilty." [WCF 2.1]
The scriptures are very plain that God will punish all who do not obey him.
Again, the creeds agree with the scriptures on this point...
"The end of God's appointing this day [wherein he will judge the world, in righteousness] is for the manifestation of the glory of his mercy, in the eternal salvation of the elect; and of his justice, in the damnation of the reprobate, who are wicked and disobedient. For then shall the righteous go into everlasting life, and receive that fullness of joy and refreshing, which shall come from the presence of the Lord: but the wicked, who know not God, and obey not the gospel of Jesus Christ, shall be cast into eternal torments, and be punished with everlasting destruction from the presence of the Lord, and from the glory of his power." [WCF 33.2, insertion 33.1]
When certain creeds give a reason for God's condemnation of sinners, they appear to completely contradict the very principle of divine justice that they have asserted.
Before we look at what the creeds say, let's see what reason is given in the Bible as to why God condemns people...
These examples show that it was God's purpose that people obey him, and they were able to do so, but they neglected or rejected God's counsel, making themselves deserving of punishment. That is a plain and simple reason for God's wrath.
Now I'd like you to note carefully how, in contrast, the creeds make God's reason obscure and unsearchable...
"The rest of mankind God was pleased, according to the unsearchable counsel of his own will, whereby he extendeth or witholdeth mercy, as he pleaseth, for the glory of his sovereign power over his creatures, to pass by; and to ordain them to dishonour and wrath for their sin, to the praise of his glorious justice." [WCF 3.7]
Note that God passes by many people, witholding mercy from them, and ordains them to wrath. These cannot be saved. The creed further says that even if people want to be saved, and try to be, they cannot be saved...
"Others, not elected, although they may be called by the ministry of the Word, and may have some common operations of the Spirit, yet they never truly come unto Christ, and therefore cannot be saved" [WCF 10.4]
The creeds admit that it is not even the fault of the damned that they are in this hopless state. They were born this way and cannot help themselves...
"[Adam and Eve] being the root of all mankind, the guilt of this sin was imputed and the same death in sin, and corrupted nature, conveyed to all their posterity descending from them by ordinary generation. From this original corruption, whereby we are utterly indisposed, disabled, and made opposite to all good, and wholly inclined to all evil, do proceed all actual transgressions." [WCF 6.3-4]
In fact the creeds hold God himself responsible for the condition of the damned, because God himself unconditionally decreed it.
By the decree of God, for the manifestation of His glory, some men and angels are predestinated unto everlasting life; and others foreordained to everlasting death. These angels and men, thus predestinated, and foreordained, are particularly and unchangeably designed, and their number so certain and definite, that it cannot be either increased or diminished. Those of mankind that are predestinated unto life, God, before the foundation of the world was laid, according to His eternal and immutable purpose, and the secret counsel and good pleasure of His will, has chosen, in Christ, unto everlasting glory, out of His mere free grace and love, without any foresight of faith, or good works, or perseverance in either of them, or any other thing in the creature, as conditions, or causes moving Him thereunto; and all to the praise of His glorious grace." [WCF 3.3-5]
So we have a God, supposed to be just, who unchangeably decrees that many should be sinners, and then punishes them eternally for being so. The lovely final invitation of the Bible (Revelation 22:17) would be meaningless if this creed were true.
Be confident that God made you good, not evil, and made you able to choose between good and evil. If you have disobeyed God, you can be forgiven by accepting his invitation in belief, repentance, and baptism (Mark 16:16; Acts 2:38-39). Jesus is able to take away the sins of "the whole world" (1John 2:1-2). This certainly includes you.
[Creed quoted: THE WESTMINSTER CONFESSION OF FAITH - 1646.]


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Absolutely no alcohol or recreational drugs for 24 hours before ceremony, and no food for ten hours beforehand. Do not over-hydrate; drink only what you need the day of ceremony as you will be required to drink two litres of water before the kambo is applied. Drinking too much water before the ceremony can lead to hyponatremia, which can be deadly.
It is recommended to take good care of yourself in the days and weeks leading up to your kambo ceremony. Eat healthy, nourishing food, and stay hydrated as you'll need your strength for the ceremony. Think about your intentions – what is drawing you to sit with kambo? What would you like to get out of your experience? How would you like to feel? What would you like to heal in your body, heart, and mind? Taking time to journal, meditate, or take a relaxing walk alone to ponder your intentions can help lend clarity to your process.
In a group kambo will be applied one by one; each person will receive ample one on one time with me or one of my assistants to help guide them through the initial effects.
Those receiving kambo for the first time will receive a basic treatment – three to nine points on the arm or leg. Initial treatments always begin with a test point – a single dot of kambo applied to gauge the person's reaction before moving forward with a full dose. Traditionally this would be on the left arm for men and the right ankle for women. Subsequent sessions may involve placement of the kambo points on chakras, meridians, acupuncture points, auricular (ear) points, or marma points as dictated by your individual intentions and needs. Each person will have to drink two litres of room temperature water within 15 minutes of taking kambo. The water acts as a depository for the toxins that kambo releases and gives you something to purge when the time comes.


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SOUNDPlay 2002
Artist Biographies
Christian Calon
Sound and Radio artist
His sound installation projects, radio or stage works are rooted in a common exploration of the listening experience. Spatial sound projection, the acousmatic conception of sound forms and the importance of listening contexts are at the heart of his creative research leading to a on-going process of investigation of new technologies.
His first works emerged in Canada and soon brought him international attention. In 1991 he was appointed to the musical direction of the GMEM (France) and in 1995, he was a guest of the DAAD in Berlin where he lived for several years. His artistic research lead at that time to the development of a widely used graphical multi-channel spatialisation system based on the principle of holophony.
In parallel in order to further his interest in the narrative forms through sound he turned to writing for the radio medium. His present work focuses on the ideas of Time, Presence and Transformation. A free-lance artist, he now lives in Montréal and develops his creation projects across the Atlantic.
Some recent landmarks
The Ulysses project (1997-00), radio and stage work for voices and multi-track sound projection. It was awarded the prestigious Lynch-Staunton prize (Canada Council) and at the unanimity of the jury, won the Grand Prix Marulic of the European Broadcasting Union (UER/EBU) 1999.
Die Zimmer der Erinnerung (The rooms of memory) (1997), radio essay (Hörspiel) on Time and creation, after the life and works of Marcel Proust. Commissionned by the German National Radio (DLR).
The standing man (1994-96), architectural sound installation for a child's voice and three-dimensional acoustical fields (24-channel spatialization). After François Villon's Epitaph. Commission of the Inventionen Festival, Berlin.
Les corps éblouis(1994), acousmatic concert work (exploration of the the guitar instrument), was awarded the 2nd prize at the Bourges International Competition ( 1994) and Distinctions at the 1995 and 1997 Ars Electronica.
His work is presented worldwide and received honours in major international competitions : Italy - Prix Russolo, USA - Newcomp Prize, UER /EBU - Prix Marulic, Germany, Austria - Ars Electronica, France - Bourges Competition. His work received assistance from the Canada Council and le Conseil des Arts et des Lettres du Québec. His music is published by Empreintes Digitales (Montréal).
Darren Copeland
Composer, sound designer, artistic director
Darren Copeland is a soundscape composer, radio artist, sound designer and concert producer. He has studied electroacoustic composition under Barry Truax (Simon Fraser University) and Dr. Jonty Harrison (University of Birmingham). His concert works have received mentions in competitions (Vancouver New Music, Luigi Russolo, Hungarian Radio, La Muse en Circuit, and Phonurgia Nova) and appeared on compilation CD releases (Storm of Drones, Radius #3, DISContact I & II, Lieu - Non Lieu, and Soundscape Vancouver). Rendu Visible, a CD devoted to his work, is available on the empreintes DIGITALes label. Other works combine his electroacoustic and theatrical backgrounds to break open disciplinary boundaries between electroacoustics, radio art, and theatre. Highlights include the adaptation of August Strindberg's A Dream Play (first radio drama at CBC conceived for broadcast in Surround 5.1), the soundscape documentaries Life Unseen and The Toronto Sound Mosaic, and a DORA nominated soundtrack for Samuel Beckett's That Time.
In addition to composing, he has written articles about listening and environmental sounds for Electronic Cottage, Musicworks Magazine, eContact! (CEC), Soundscape: Journal of Acoustic Ecology, and The Journal for Electroacoustic Music (Sonic Arts Network) as well as CD, concert and book reviews for Musicworks Magazine, The Whole Note, and Soundscape: The Journal of Acoustic Ecology.
As a producer and administrator, fond memories lie with Wireless Graffiti, a live-to-air radio extravaganza in 1993 co-produced by Rumble Theatre and Vancouver Pro Musica. After active histories with Vancouver Pro Musica, the Standing Wave Ensemble, and the Communauté Électroacoustique Canadienne/Canadian Electroacoustic Community (CEC) from 1990 to 1996, he now serves on the board of the Canadian Association for Sound Ecology (CASE) and is the Artistic Director for New Adventures in Sound Art
Shelley Hirsch
Vocalist, Composer, Performance Artist
Shelley Hirsch is a vocalist, composer, performance artist, whose written and improvised work for stage, concert, record, film, television and radio has been presented on 5 continents. Hirsch has been called "enormously inventive, scathingly satiric and virtuosic... a brilliant overwhelming presence on stage" by the NY Times. Her work incorporates extended vocal techniques, real and imaginary language, international music styles, stream of consciousness, electronics, characterizations, storytelling, movement and mixed visual media.
She has performed improvised music with musicians Anthony Coleman, Christian Marclay, Ikue Mori, Hans Reichel, Elliot Sharpe, Joey Baron, Konk Pack, Paul Lovens, Toshio Kajiwara, Fred Frith, DJ Olive among others and can be heard on dozens of CDs including her fall releases of her Solo CD "The Far In Far Out Worlds of Shelley Hirsch" on Tzadik (Nov 2001), and "Duets" with guitarist Uchihashi Kasuhisa on Innocence Records and "States" on Tellus; her storytelling CD "O Little Town of East New York" on Tzadik; "Haiku Lingo" on No Mans Land (both with keyboardist David Weinstein) and with the groups September Band and X-Communication (both on FMP). She can also be heard on CDs by Richard Teitelbaum, Jon Rose, Elliot Sharp, Nicolas Collins, John Zorn, David Moss, Sven Ake Johannson and Alexander Von Schlippenbach, Butch Morris, Jim Staley, Hans Koch and Martin Schutz and many compilation CDs.
Hirsch has presented her mostly staged solo pieces at prestigious festivals, theaters and museums around the world including The Hebbel Theater (Berlin), WienerFestWochen (Vienna), The Zurcher TheaterSpektakel (Zurich) Adelaide State Theater (Australia) The Whitney Museum (NYC). She is the subject of 2 short films made for German TV and is a lead actor in the award winning "Wild Sound" and "OrianienStr" a feature film produced for ZDF television Hirsch is the recipient of many grants, fellowships, awards and residencies in music composition, performance art, new forms, and interdisciplinary categories.
Nilan Perera
Nilan Perera has been an active member of the Canadian creative music and performance scene since 1983. He has been involved in some of the most forward-looking, influential and radical ensembles of the past 19 years including NOMA, Bill Groves Not King Fudge, Handslang and the Excalceolators. He has also performed and recorded with Vinnie Golia, Don Preston, Mary Margaret OHara, Glen Hall, John Oswald, Vinx, Al MacDowell and Michael Ondaatje.
His decade long association with guitarist/composer and iconoclast, Rainer Wiens has led him into the world of Dance/Theatre as a composer/performer/instrumentalist with Wiens and Jan Komarek in Sound Image Theatre and most recently, with Susanna Hoods hum dansoundart.
He is currently a member of trip-hop group Lalâ prepared guitar trio Ferrobaci (with Wiens and Bill Parsons), electroacoustic/improv duo Smash and Teeny (with Sara Peebles),Susanna Hoods hum dansoundart and radio art duo FaMished AMerica (w/Susanna Hood) as well as performing and composing as a soloist on guitar.
Nilan is featured on several recordings.
He can also speak in sentences and can nearly dress himself
Sarah Peebles
"Sarah Peebles has one of the most careful and subtle ears of any composer of musique concrète working today." -- Terra Nova Journal (MIT Press)
Composer/performer Sarah Peebles integrates sounds she has gathered from natural habitats and cityscapes in North America and Japan into her improvisations and sound works - often exploring alternate performance settings, such as museums, bamboo groves, temples and parks. Her work with electroacoustics focuses heavily on sampled sounds, which are called forth and manipulated on the fly, using a Macintosh computer running Max, Sample Cell and other programs. She gathers and alters her own sounds, which run the gamut from dust pans, home-made reeds and bullroarers, to hummingbirds, ignited vapors, cicadas and water. Peebles also draws upon the sustained tones of the shoh - a free-reed mouth-organ noted for its unique timbre and tendency to 'throw' sound in unexpected ways.
Uniting her music with diverse arts, she has collaborated with spoken word, dance, video and installation artists, artificial intelligence researchers and other musicians. Additionally, she is a member of Cinnamon Sphere trio (calligraphy performance by Chung Gong Ha, with improvised soundscapes by Peebles and guitarist Nilan Perera), active in performing as well as producing video and audio works.
Peebles' work in new music has included performances in Canada, U.S.A., Australia, Japan, and the U.K. at such venues as The Kitchen, Roulette Intermedium (NYC), Studio Kinshicho (Tokyo), SIGGRAPH Electronic Theater Evening, Adelaide Festival of Arts-The Listening Room (ABC), and production/performance for Sonic Circuits festivals in Toronto and Minneapolis. She is published on a variety of labels, including innova, Barooni (with David Toop), MusicWorks, Hornblower, The Aerial and others. Peebles has also studied and performed traditional and contemporary music in Japan independently and as a Japan Foundation Uchida Fellow.
David Toop
Writer & Sound Artist
Musician, writer and music curator, born in 1949 near London. He lives in London. Recent books include: Ocean of Sound: Aether Talk, Ambient Sound and Imaginary Worlds (Serpent's Tail, 1995), Exotica: Fabricated Soundscapes in a Real World (Serpent's Tail, Autumn/winter 1998) and a short story: Acid Burns - published in Intoxication: An Anthology of Stimulant Based Writing, (Serpent's Tail, 1998). Past work includes: The Rap Attack in 1984 (now in its second edition as Rap Attack 2). He has also written for many publications, including The Wire, GQ, The Face, Arena, The Times, Mojo, Vogue, Dazed and Confused, The Sunday Times, Billboard, Spin and the Cambridge Companion to Singing.
David recently composed the music for the Aqua Matrix outdoor show, closing each day at Lisbon Expo 98 from May until September. Recent solo albums include: Screen Ceremonies (Wire Editions, 1995), Pink Noir (Virgin Records, 1996) and Spirit World (Virgin Records, 1997). Recent compilation albums include: an accompanying double CD Ocean of Sound (Virgin Records), followed by Crooning On Venus, Sugar and Poison, Booming On Pluto and Guitars On Mars. Past albums include: New and Rediscovered Musical Instruments, released on Brian Eno's Obscure label in 1975, and Buried Dreams (with sound sculptor Max Eastley), released on Beyond in 1994. In 1978 he recorded Yanomami shamanistic ceremonies in Amazonas, southern Venezuela. Examples of these recordings have been released on Quartz, Touch and, in 1995, Sub Rosa.
In 1994 he wrote database material on shamanism, trance, etc. for The Shamen's ongoing multimedia project. David has also recorded collaborations with Paul SchÙtze, Jon Hassell, Evan Parker, Talvin Singh, Robert Hampson, Bedouin Ascent, Amelia Cuni, Max Eastley, Kaffe Matthews, Twisted Science, Scanner, Witchman, Prince Far I, John Zorn, Flying Lizards, and many improvising musicians, including Evan Parker, Lol Coxhill, Toshinori Kondo and Hugh Davies. He has collaborated with artists in many other fields, including theatre music for Steven Berkoff, Japanese Butoh with dance innovator Mitsutaka Ishii, plus performance art, sound art, sound poetry and television soundtracks.


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KUALA LUMPUR: A total 2.2 million documented migrant workers in Malaysia will be fully covered under the Socso Act for employment-related injury starting Jan 1, 2020.
The move further signals Malaysia's adherence to international labour laws that guarantee basic human rights and decent living for all workers.
In a statement today, Malaysian Trades Union Congress (MTUC) secretary-general, J. Solomon, said the Act was in the best interest of migrant workers who have contributed immensely to this nation.
The government announced the Act's implementation in January 2019, but due to the insurance policies purchased under the Workmen Compensation Act, its true effect will only be felt from next year.
Migrant workers were initially protected under the Socso Act 1969, but in 1993, the Malaysian government placed them under the Workmen Compensation Act 1952, which resulted in unequal treatment compared to national workers, Solomon said.
A complaint then arose at the International Labour Organisation (ILO) in 1996 and the plight of millions of migrant workers who had limited or no Socso coverage came under scrutiny.
In June 2018, the world body dispatched a high-powered direct contact mission (DCM) to assist the government and other stakeholders in implementing recommendations by a committee and to ascertain Putrajaya's adherence to Convention 19 (C19).
It compels countries to ensure equality of treatment (accident compensation) for national and foreign workers.
Solomon said although the government had announced that migrant workers with permits will enjoy Socso coverage from this year, many of them faced difficulty in receiving medical care and compensation, among other things.
"Apart from this, MTUC is also very concerned about the fate of millions of undocumented workers in Malaysia who are denied any form of coverage in the event of an industrial accident at the workplace.
"By providing such coverage to undocumented workers, the government will not only be complying with C19, but can implement the necessary mechanism to legalise these workers," he said.
During the three days the seven-member DCM was here, the matter of effective access to healthcare in case of a workplace injury, was studied.
Despite the government announcing foreign workers would have Socso coverage, teething problems arose including Putrajaya's role in ensuring every migrant worker -- legal or undocumented – enjoys Socso benefits on par with local workers.
The problems are not being effectively addressed largely because of the absence of good consultation with the tripartite social partners, Solomon said.
This was also one of the DCM's findings, and it was concluded that the tripartite consultative and communication process may benefit from their insights in the implementation and work plan, with effective follow-up.
Solomon said the DCM would report its findings on Malaysia's compliance with C19 and make the necessary recommendations to the ILO, which would then take up the relevant issues with the Malaysian government.
MTUC has been relentless in pursuing this matter, Solomon said, to ensure migrants do not remain vulnerable in Malaysia. — Bernama


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Ballard Power Systems (Vancouver, Canada) announced that it will supply Richmond, B.C.-based General Hydrogen (Canada) Corp. with more than 100 Mark9 SSL® fuel cells. The fuel cells will range in power from 4.8 kilowatts to 21.1 kilowatts, and will be integrated into General Hydrogen's power units for early commercial sales in the lift-truck market.
"We are now into commercial sales and this agreement with Ballard provides a solid foundation going forward, as we have secured a source of product that will allow us to be extremely competitive in the Class 1 forklift truck market," said Frank Trotter, General Hydrogen's president and CEO. "The lift truck market for battery replacement technology is here and now and represents a major market opportunity for General Hydrogen. The market is driven not only by the economic need to be as efficient as possible, but also the requirement to meet ever-increasing environmental standards in the workplace for the health and safety of workers."
Source: Ballard Power Systems


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Two 12-residue peptides were synthesized by the solid-phase method as structural analogs of a Ca2+-binding loop of rabbit skeletal troponin C. The sequence of the analogs corresponds to the binding loop of the Ca2+-specific low affinity binding site II (residues 63-74) but with two amino acid substitutions. In one analog, Phe-72 was replaced by tyrosine. In the other Gly-66 was substituted by serine and Phe-72 by tyrosine. The intrinsic fluorescence of the peptides was enhanced upon addition of Tb3+ or large excess of Ca2+. From the enhancement of Tb3+ emission association constants in the range (2-3) × 105m-1 and a binding stoichiometry of 1 were determined for Tb3+ binding to the peptides. Large excess of Ca2+ displaced Tb3+ from the Tb3+-peptide complexes and from these results apparent stability constants of 500-700 m-1 were deduced for Ca2+ binding. Preliminary proton nuclear magnetic resonance results on one of the peptides indicated that La3+ induced considerable perturbation of the amide proton resonances of several residues, including the aspartate at position 3, the tyrosine at position 10, and the two glutamates at the C-terminus. The results suggest involvement of these residues in cation coordination.
Original language | English (US) |
Pages (from-to) | 530-540 |
Number of pages | 11 |
Journal | Archives of Biochemistry and Biophysics |
Volume | 220 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 1983 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology


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FDA Approves ALECENSA® (alectinib) for Anaplastic Lymphoma Kinase (ALK)–positive, Metastatic Non-Small Cell Lung Cancer (NSCLC)
On December 11, 2015, the United States Food and Drug Administration (FDA) approved ALECENSA (alectinib) for the treatment of patients with ALK-positive metastatic NSCLC who have progressed on or are intolerant to crizotinib. The recommended dose of ALECENSA is 600 mg orally twice daily (BID) with food until disease progression or unacceptable toxicity.
Mechanism of Action (MOA), General Pharmacokinetics (PK) and Pharmacodynamics (PD)
- MOA: Alectinib and its major active metabolite M4 are tyrosine kinase inhibitors that target ALK and RET. M4 is a major circulating metabolite with similar in vitro potency and activity to alectinib.
- Dose proportionality: Alectinib exhibited dose-proportional increases in systemic exposure over the dose range of 460 mg to 900 mg (i.e., 0.75 times to 1.5 times the approved recommended dosage).
- Accumulation: The geometric mean accumulation is ~6-fold for both alectinib and M4 at steady-state.
- Plasma protein binding: Both alectinib and M4 are greater than 99% bound to human plasma proteins and independent of plasma concentrations.
- Terminal half-life (mean): The geometric mean elimination half-life is 33 hours for alectinib and 31 hours for M4.
- Metabolism: Alectinib undergoes metabolism by CYP3A4 to its major active metabolite M4; the geometric mean metabolite to parent exposure ratio at steady-state concentrations is about 0.40. M4 is subsequently metabolized by CYP3A4.
- Excretion: Ninety-eight percent of the radioactivity was excreted in feces following oral administration of a single radiolabeled dose of alectinib under fed conditions. Eighty-four percent of the dose was excreted as unchanged alectinib and 6% of the dose was excreted as M4. Excretion of radioactivity in urine was less than 0.5% of administered radiolabeled dose of alectinib.
- Exposure-efficacy and Exposure-safety: No significant exposure-response (E-R) relationships were identified for the best overall response (BOR), BOR in the central nervous system (CNS), grade 3 or higher adverse events, serious adverse events or adverse events of special interest of any grade at a dose of 600 mg BID.
Drug Interaction Potential
- No clinically meaningful effect on the combined exposure of alectinib plus M4 was observed in clinical studies following co-administration of ALECENSA with a strong CYP3A inhibitor (posaconazole), a strong CYP3A inducer (rifampin), or an acid-reducing agent (esomeprazole).
- No clinically meaningful effect on the exposure of midazolam (sensitive CYP3A substrate) or repaglinide (sensitive CYP2C8 substrate) is expected following co-administration with ALECENSA.
Use in Specific Populations
No dose adjustment is recommended for patients with mild and moderate renal impairment or with mild hepatic impairment (defined by National Cancer Institute). Age, body weight, mild hepatic impairment, mild to moderate renal impairment (CLcr 30 to 89 mL/min), race (White, Asian and Other), and sex had no clinically meaningful effect on the systemic exposure of alectinib and M4. The pharmacokinetics of alectinib has not been studied in patients with severe renal impairment, end-stage renal disease or moderate to severe hepatic impairment.
Safety and Efficacy
The safety and efficacy of ALECENSA were established in two single-arm, multicenter clinical trials conducted in patients with locally advanced metastatic ALK-positive NSCLC, who have progressed on crizotinib. The objective response rate (ORR) was 38% (95% CI: 28%, 49%) by IRC and 46% (95% CI: 35%, 57%) by Investigator for patients in study 1 after a median follow-up of 4.8 months and 44% (95% CI: 36%, 53%) by IRC and 48% (95% CI: 39%, 57%) by Investigator for patients in study 2 after a median follow-up of 10.9 months. The median duration of response was 7.5 months (95% CI: 4.9, not estimable (NE)) by IRC and NE (95% CI: 4.9, NE) by Investigator for Study 1 and was 11.2 months (95% CI: 9.6, NE) by IRC and 7.8 months (95% CI: 7.4, 9.2) for study 2.
An assessment of the ORR and duration of response for central nervous system (CNS) metastases was completed in 51 patients with measurable lesions in the CNS at baseline enrolled into these studies. The ORR in the central nervous system was 61% (95% CI: 46%, 74%) with a median duration of response of 9.1 months (95% CI: 5.8, NE).
The most common adverse reactions (incidence ≥ 20%) were fatigue, constipation, edema and myalgia. Warning and Precautions include hepatotoxicity, interstitial lung disease/pneumonitis, bradycardia, severe myalgia and creatine phopsphokinase elevation and embryo-fetal toxicity.
Full prescribing information is available at http://go.usa.gov/ckX7b.
Healthcare professionals should report all serious adverse events suspected to be associated with the use of any medicine and device to FDA's MedWatch Reporting System by completing a form online at http://www.fda.gov/medwatch/ report.htm, by faxing (1-800-FDA-0178) or mailing the postage-paid address form provided online, or by telephone (1-800-FDA-1088).
The Office of Clinical Pharmacology (OCP) regulatory reviews for new drugs or biologics are often available for viewing shortly following approval at the Agency's Drugs@FDA website (http://go.usa.gov/ckXH2).
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Refugee camps in crisis areas depend on energy for powering the public infrastructure (including medical facilities), refugee households (for cooking, washing, heating), and for the needs of small enterprises. An average camp hosting around 20,000 people needs up to 20 megawatt hours of energy per day. This is roughly the same amount as is used by the energy-related infrastructure of a small town. Most refugee camps, however, are located in remote areas at the periphery of their country, and are not connected to the local grid. This is why virtually of the electricity used in camps like these – if there is any electricity at all – comes from expensive and environmentally harmful diesel generators. And these camps tend to operate for a long time, with the average one closing after 17 years, and some a lot longer.
Save on electricity bills and spend money more wisely
There are much more efficient, sustainable and cost-effective ways of powering up refugee camps. A study commissioned by the UN Refugee Agency (UNHCR) has found that some 323 million US dollars could be saved in fuel costs, simply by replacing inefficient cooking stoves with better ones and by switching to solar lamps. This money could then be used for other humanitarian purposes, notably to improve the lives of the people living in refugee camps. As an added benefit to this, these measures would also cut carbon emissions by some 7 million tonnes.
This is why the UNHCR and Chatham House have formed a joint initiative to promote a sustainable energy supply for refugee camps, which is to be based upon a high share of renewables in the energy mix and energy efficiency standards twice as high as the current ones. Very often, the geography of the camps is favourable to renewables, with many camps located in sunny areas where hybrid installations (PV installations with back-up diesel generators) are the method of choice for electricity generation.
A fresh campaign for renewables in refugee camps
In mid-January, representatives of UNHCR, UNITAR, the UN Foundation, the International Organization for Migrants (IOM) and of GIZ came together in Berlin for an international conference that took place under the motto "Energy for Displaced People: A Global Plan of Action for Sustainable Energy Solutions in Situations of Displacement". Participants had set themselves the task of preparing a strategic plan for action as to how the various challenges, ranging from cooking to recharging mobile phones to setting up much bigger electricity installations, could be addressed. A number of small working groups were established at the conference. They now have until June 2018 to draft a roadmap complete with specific projects and timelines.
German Energy Solutions Initiative supports quest for energy solutions
The Federal Ministry for Economic Affairs and Energy supports the initiative for sustainable energy solutions for displaced people as part of its German Energy Solutions Initiative. The ministry has had the energy needs of refugee camps analysed and fields for action outlined (click here to read the study; in German only). Furthermore, 65 German companies capable of delivering suitable energy solutions for refugee camps have been identified. This was done in response to work conducted by GIZ, which showed that there already are technical solutions that are both reliable and economically viable and which could be used in refugee camps. These include battery storage containers, distributed water and electricity stations, mobile solar installations, and solar home systems solutions. These technologies were presented by German companies at an event organised by the Ministry and coinciding with the international conference mentioned above (for further information in German, please click here).


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In a season that seems certain to reach at least 50 losses in regulation, Sunday's in Chicago might have been the most demoralizing for the Colorado Avalanche. Regulation loss No. 48 (they have three in OT) saw the Avs jump out to a 3-1 second-period lead, only to fall 6-3 after giving up five goals in the third.
Mikhail Grigorenko had the Avs feeling optimistic through the first period when his pair of goals gave Colorado a 2-1 lead. Patrick Kane scored his 32nd of the year to open the scoring. Sven Andrighetto would double Colorado's advantage at 16:24 in the second, the frame's only goal. Jeremy Smith stopped 19 of 20 shots he faced through two periods.
But Smith and the Avalanche could not contain the relentless Chicago attack. The Blackhawks exploded halfway through the third period with three goals in a span of 34 seconds. Jonathan Toews scored twice in the period and Marcus Kruger scored an empty-netter to double up Colorado.
This was the fourth of five meetings between the Central Division teams this year. Chicago has earned points in each meeting, winning three handily and suffering an overtime loss. Colorado has surrendered 17 goals to the Hawks through the first four meetings. They will square off one final time this season at Pepsi Center on April 4.