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LAS VEGAS — We are here! The Super Bowl! The Big Game!
And it's a wonderful, fantastic, simply a super matchup between two strong contenders with star players and coaches on every single unit.
On this week's edition of The Overhang, I will preview when both the San Francisco 49ers and the Kansas City Chiefs have the ball this Sunday. (Sorry special teams, you might still be important!) There will be a few numbers to note, players I'm keeping an eye on outside of the typical stars, an important matchup that can swing the game, as well as props. Lots of props.
[How to watch the Super Bowl: TV channels, streaming and mobile options]
All data via TruMedia unless otherwise noted. All betting odds via BetMGM.com at time of writing.
When the 49ers have the ball …
Numbers to know
That's where the 2023 49ers offense ranks in combined success rate and explosive play (rushes of 12-plus yards, passes of 16-plus yards) rate among the 766 NFL offenses since the 2000 season. Their 64.9% combined rate trails only the 2011 New Orleans Saints (when Drew Brees finished with over 5,400 passing yards) and the 2004 Indianapolis Colts (when Peyton Manning delivered one of the best, if not the best, seasons from a quarterback).
Those Saints and Colts teams were more efficient, at least in terms of success rate, than this 49ers offense, but this 49ers offense is far more explosive, especially in the run game. It's one of the best offenses we've seen since the turn of the millennium, no matter how you slice it up.
Head coach Kyle Shanahan has had several strong offenses before, but this season's version feels like his magnum opus. A run game with the best running back in the game and several other All-Pro caliber skill players, plus a quarterback driving with his pedal to the metal. It can feel unguardable because …
That is the combined target and designed rush per snap rate of Christian McCaffrey and Deebo Samuel on the 260 snaps the 49ers faced against Cover 2 and Cover 6, also known as "cloud coverages" that feature at least one Cover 2 side in the defensive structure. A "cloud" side will put two defenders over one outside wide receiver (like Brandon Aiyuk), with the cornerback underneath and a safety over the top for help. The "cloud" side also changes the angles in the run game, with the cornerback now part of the run support instead of the safety.
You know who loves running Cover 2? Blitz-happy defensive coordinator Steve Spagnuolo, using Cover 2 as the natural yin to the chaotic yang of pressure-heavy looks. The Chiefs have used Cover 2 at the fourth-highest rate in the NFL and used it on a season-high 40% of their snaps against the Miami Dolphins in their wild-card matchup, another offense from the Shanahan tree.
Even in the first game against the Dolphins in Week 9, the Chiefs used Cover 2 variations to disrupt the timing of the outside wide receivers and flow of the entire offense, with the Chiefs' cornerbacks constantly jamming outside wide receivers.
Shanahan is deliberate with how he attacks certain looks, and against cloud coverages, he uses McCaffrey and Samuel to do his point-hoarding bidding. No safeties in the box means that McCaffrey can get a matchup against a linebacker, where he is nearly going to be at an advantage every time, and it also creates space over the middle for Samuel to go to work underneath, putting Samuel on islands against those same linebackers and finding space to use his exceptional yards-after-catch ability.
Cover 2 defenses, at least against spread formation looks, will also put the slot defender in a bind, with that defender having responsibilities in the run game but also with inside leverage coverage on the slot. If Chiefs slot defender Trent McDuffie ever gets nosey against the 49ers' run game and looks to play the run first or Spagnuolo uses the Cover 2 base shell to bring McDuffie on a blitz look, then also look for Samuel to get peppered with quick-hitting flats, bubbles and screens to attack the void created. With players like Aiyuk and George Kittle being used more on chunk opportunities outside and on play-action.
76 (but really, just pick a number)
This is the best defense Spagnuolo has had during his tenure in Kansas City. Period. Underlying statistics indicate this (success rate, EPA per play, yards per play) but also just straight-up eye test.
This defense is the dividends of a flurry of investments this Chiefs franchise made recently, which blossomed into an upper-echelon unit that has Spagnuolo showing off his bag of tricks. Defensive lineman Chris Jones is the key cog of the unit, but all three levels have filled out with stars and valuable role players. They can impact the opponents through the disruptive two-man game that George Karlaftis has developed with Jones; the world's most interesting linebackers room; McDuffie on blitzes (he finished with 10 quarterback hits this season, the same amount as Jalen Carter, Arden Key and Daron Payne); or just the sound tackling from the entire Chiefs defensive backs room. Kansas City finished the regular season with 76 missed tackles, the fewest amount of missed tackles from a Chiefs defense under Spagnuolo and the sixth-best mark this season, according to Pro Football Reference.
I mean just look at this group erasing YAC opportunities and filling the run game time and again, particularly safety no. 20 Justin Reid:
Against any explosive offense, especially one with the sixth-highest explosive play rate in over two decades, tackling is the fundamental answer to limit big plays. With an aggressive defensive coordinator like Spagnuolo, where blitzes can create big plays for both sides, that sound tackling ability will be so important and well-tested by the 49ers throughout the game.
Key matchup: 49ers offense vs. Chiefs defense
Chris Jones and George Karlaftis vs. the right side of the 49ers' offensive line
There are incredible matchups everywhere on this side of the ball. L'Jarius Sneed against Brandon Aiyuk, McDuffie against Samuel, Spags against Shanahan.
But before this historically efficient offense can get cooking, it has to block up front. The right side of the 49ers' offensive line is a potential Achilles heel to be attacked by Jones and Karlaftis, who will invert their alignments, with Jones on the outside and Karlaftis on the inside, to pick at their biggest mismatches and create disruption with various twists or just simply beating the blocker across from them.
Right tackle Colton McKivitz in particular might need help throughout the night, especially if Jones is aligned across from him. But look to see how the 49ers plan to mitigate any damage from that side and keep their high-flying offense in the air. And keep Brock Purdy away from his chaotic adventures.
Player to watch: Leo Chenal, LB, Chiefs
The Chiefs have used four-defensive back personnel (i.e. base) at the highest rate ever since Spagnuolo's arrival, with Chenal becoming an interesting chess piece that Spagnuolo has loved to use this season.
Chenal is a uniquely skilled player who is strong and explosive, but best going forward and not side to side. The Chiefs might trot out the same base personnel on back-to-back plays, but they will align Chenal (and other players) throughout the defense based on what they're trying to accomplish.
There's No. 54 Chenal, effectively as an interior defensive lineman, creating a "bear" front and de facto 3-4 look out of the same personnel:
Or he can be used as a simple off-ball linebacker in a typical 4-3 look:
Or in other five-down looks, there's Chenal as an outside linebacker in a front, waiting to stonewall the wide receiver attempting to block him at the point of attack and blowing up the run play:
Chenal has limitations in coverage, which could lead to a mismatch against McCaffrey or Kittle, but his unique skills have been weaponized by Spagnuolo this season. Seeing where 54 aligns will be indicative of how the Chiefs want to attack.
Prop bets for 49ers offense vs. Chiefs defense
Brock Purdy over 20.5 pass completions (-135)
Brock Purdy over 31.5 pass attempts (+115)
Brock Purdy over 3.5 rush attempts (+110)
Brock Purdy over .5 interception throw (-120)
All of those quick-hitters on the bubbles and flats, plays packaged with runs to provide answers against box counts and blitzes, will lead to a pass-heavy game script from Purdy. The 49ers throw the ball over 70% of the time when facing Cover 2 as well, with the Chiefs punishing Purdy for one of his chaotic moments, something other teams weren't able to fully take advantage of during the playoffs. (If you're feeling particularly spicy, an anytime touchdown wager from the Chiefs' defense and special teams is currently at +600. If one of those Purdy throws heads the wrong way …)
With the varying coverage looks that the Chiefs will use, too, I can see Purdy calling his own number and trying to make a play with his legs when all else fails. Also, the Chiefs used Cover 2-man more frequently than any other defense this season. A natural answer for quarterbacks against two-man? Scramble.
As for who will be catching those passes:
Samuel over 4.5 receptions (-150, would be comfortable bumping this to 5.5 for better odds)
McCaffrey over 34.5 receiving yards (-115)
McCaffrey under 90.5 rushing yards (-115)
George Kittle over 21.5 yards longest reception (-115)
George Kittle anytime TD (+175)
Whether it's a soft coverage or blitz-heavy gameplan from the Chiefs, Samuel is going to get fed short throws again and again. I'm looking at touch props for Samuel and not just yards.
McCaffrey will have natural advantages through the air, too. But the Chiefs' game plan is going to make the 49ers' run game a bit more boom-or-bust, which might limit his yards on the ground, especially if it's a wonky game script. So, I'll also take the under on McCaffrey's rush yards as well.
I don't think Kittle will get a ton of touches, but he'll get big ones. A possible red-zone or big-play touchdown, taking advantage of a dropping defensive lineman or simply sprinting by a linebacker. I think Kittle will have a big play in this game.
When the Chiefs have the ball …
Numbers to know
That's the rate of explosive passes that the 49ers' defense has allowed this season, tied for best in the NFL with the Cleveland Browns.
San Francisco, particularly with linebackers Fred Warner and Dre Greenlaw along with Deommodore Lenoir when he's in the slot, thrive on squeezing underneath throws. Warner will quite literally run the routes for opposing players, forcing quarterbacks to get to a checkdown before the 49ers' pass rush gets home. Then Warner and his friends come down and clean up the mess and create another long third-down situation for the opposition.
This continuously makes quarterbacks be patient and keep grinding away with singles throughout the day, something most quarterbacks don't have the discipline (or ability) to do for dozens of snaps a game.
Patrick Mahomes, however, gets on base like the Splendid Splinter. Along with all of the exciting out-of-structure plays that litter his highlights, Mahomes is completely fine hanging in the pocket and peppering a defense, creating small profits on every single play before cashing it all in in the end zone, something the excellent Ravens defense saw firsthand in the first half of the AFC championship game.
The battle of wits between Mahomes and Warner is worthy of a rematch. Their first meeting in the Super Bowl brought out some cool moments between the two:
#Chiefs hit the Leak play (brilliant throw by Mahomes), but watch #54 Fred Warner communicate to the other #49ers after the motion. He has seen something on film and sniffs out that a PA shot is coming.
He doesn't even come up on the fake, just confirms and gets into coverage. pic.twitter.com/uks2xE6jlp
— Nate Tice (@Nate_Tice) February 4, 2020
That's how many yards teams have averaged when using tosses and pin-pull run schemes against the 49ers. It's something the Packers and Lions successfully leaned into this postseason:
The aggressive nature of the 49ers' defensive ends can create plenty of havoc against offenses, but can also be used against them when teams attack with surprise and angles like the Packers did by pinning Nick Bosa and Chase Young with their wide receivers from the outside.
Look for the Chiefs, who have had a bottom-five run game this season but have had much better stretches in the postseason, to use their time off and pick at this weakness of the 49ers because …
27th, 28th, 29th
That is how the 49ers' defense ranked this season in terms of explosive rush rate allowed, rush success rate allowed and first downs per rush allowed to running backs.
There is a trade-off for the ears-pinned-back style that the 49ers' defensive line plays, as well as how much anticipation the highly intelligent Warner wields. Once in a while he can take one step too many against a jet motion or some moving piece. The defensive line gets its pressures and moves the quarterback off his launch point, especially when the QB is forced to progress, but that "quarterback-first" mindset can hinder some consistency in the run game. Does Bosa see his matchup against Jawaan Taylor, lick his chops, and decide that he's going to take over? Perhaps negating some other responsibilities?
Offenses have had even more success when the 49ers are in their own version of base personnel, with linebacker Oren Burks on the field and Lenoir kicked back outside, something that is more pertinent because of Kansas City's frequent usage of multi-tight end looks. The Chiefs have leaned into those even more in the postseason, using multiple tight ends on 27 of 47 snaps against the Buffalo Bills in the divisional round and 13 personnel (three tight ends) at their highest rate ever in a game since Mahomes took over as the starting quarterback against the Dolphins.
Again, the Chiefs have not had the solid and efficient run game that we typically see with an Andy Reid offense. In fact, it's been downright bad at times this season. So this is kind of a stoppable force vs. movable object type of matchup. But there have been more flashes as the Chiefs tweaked which concepts they use (look for those outside hitters this week and perhaps some pullers), and Reid and offensive line coach Andy Heck have had a couple weeks to come up with a game plan. What they decide to poke at, outside of using the best quarterback in the game, will be interesting.
Key Matchup
Whoever is guarding Travis Kelce when the 49ers are in man coverage
Mahomes vs. Warner is a championship-caliber matchup, but the "covering Travis Kelce" riddle is something I'm curious to see how the 49ers solve. The 49ers will mix in man coverage on passing downs (their 29.6% Cover 1 rate on third and fourth downs ranked 12th in the regular season). They often like to create a five-man blitz look and single blocks for their talented defensive line and (typically) Warner, hoping to create a mismatch and win before the quarterback can get rid of the ball.
But that man coverage, especially against a quarterback who is comfortable extending plays, can be a dicey proposition for this 49ers, even if they want to use it as a changeup. Not only is there Mahomes to contain, but who will play man-up on Kelce is the first answer to solve if defensive coordinator Steve Wilks still wants to sprinkle it in. Perhaps we see a double-Kelce variation, which would then open up a one-on-one for a Chiefs wide receiver to win. And, well, that can be a dicey proposition for the Chiefs, too!
Players to Watch: Rashee Rice, WR, Chiefs; Chase Young, DE, 49ers
Look for Rashee Rice to get plenty of action early. The 49ers predominantly like to play in zone coverage looks on early downs, especially starting out of quarters shells. Like the earlier discussion of Deebo Samuel against the Chiefs' defense, this can make the slot defender the conflict defender, putting him in a bind to play the run or his coverage responsibilities. Offenses, like the Bengals earlier this season, loved using flats and bubbles throws to complement their run game. Look for the Chiefs to do the same with Rice.
Young is also an important X-factor for the 49ers' defense. The Niners traded for Young after a solid stretch to start the year for Washington, but he has since been inconsistent. Young needs to play sound against the run and make an impact of some sort to help Bosa and Javon Hargrave help corral Mahomes.
Prop bets for Chiefs offense vs. 49ers defense
Patrick Mahomes over 26.5 rushing yards (-125)
Patrick Mahomes over 1.5 passing touchdowns (-155)
Game script matters so much for Mahomes' end game stats, but I think there will be plenty of scrambling opportunities for him, whether it's against the late-down man coverage looks, which are great for scrambling opportunities, or zone coverage. It's worth noting that no quarterback scrambles more frequently against zone coverage than Mahomes.
Also think once the Chiefs get close, they're letting Mahomes go to work in the red zone. Particularly to …
Travis Kelce over 69.5 receiving yards (-120)
Travis Kelce 2+ touchdowns scored (+550)
The plays go through the stars in the biggest moments. I think Kelce gets fed early and often and gets several opportunities to score once the Chiefs get inside the 20-yard line.
Rashee Rice 33+ receiving yards in the first half (-115)
Rashee Rice anytime touchdown scorer (+125)
I think that opening script for the Chiefs sees plenty of action going Rice's way. If that sustains, or whether those touches to Rice turn into run plays once the box softens up, will depend on how the 49ers' defense adjusts. So I'm going to keep this for the early portion of the game.
Super Bowl LVIII pick: Chiefs 27, 49ers 24
I think this game will start off with some back-and-forth haymakers when both offenses are in their opening script. Kansas City's defense adjusts throughout the game to slow down the bleeding and even create an explosive play of its own, helping the Chiefs keep control of the game before a late drive helps them take the lead.
Either way, I expect this to be a barnburner. A super matchup worthy of the name. Enjoy!


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Today, Toyota has announced the all new GR 86 coupe, which is replacing the outgoing GT86 for the company's mid range, two door, four seater sports coupe. The GR 86 is sitting below the GR Supra in the line up.
Straight away, Toyota has made some much needed improvements. The general consensus was that the old GT 86 was underpowered, with 197bhp and 151lb ft torque. So Toyota has improved this as the new car now generates 232bhp and 184lb ft torque. The increased power means the GR 86 is faster from 0-60mph, at 6.3 seconds, 1.1 seconds faster.
Like last time, Toyota and Subaru are partnering up to make the GR 86 and the BRZ. Subaru announced the BRZ in November last year, and that car wont be coming to the UK, instead only in Japan and the US.
The GR 86 will be going on sale in Japan this autumn, with a release confirmed for the UK and Europe, with no date set yet.

subset: commoncrawl


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KBPE 10th Standard Biology Exam Question Paper 2020 with Solutions – Free Download
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Download Kerala Board SSLC 2020 Biology Question Paper
Download Kerala Board SSLC 2020 Biology Question Paper With Solutions
Kerala Board Class 10 Biology 2020 Question Paper with Solutions
1. The process that leads to the formation of impulses in photoreceptors is:
a. The dissociation of visual pigments in the presence of light
b. Formation of vitamin A in the presence of light
c. The transmission of impulses to cerebrum through the optical nerve
d. The reunion of retinal and opsin
Answer:(a) The dissociation of visual pigments in the presence of light
2. What are indicated by (i) and (ii) in the illustration of a DNA molecule given below?
(i) Guanine
(ii) Phosphate
3. Analyse the given symptoms and identify the disease
- Low metabolic rate
- Hypertension
- Inflammation in tissues
Answer: After analysing the given symptoms, we can identify that myxoedema is the disease.
4. Based on the given model, make a suitable pair from the following box:
Charles Darwin- The theory of natural selection.
HugodeVries, Lamarck,
Chemical evolution theory, Panspermia, Mutation Theory, Robert Malthus |
Answer: Hugo deVries – Mutation theory
5. In plants, which is the chemical substance that prevents the germs, that have crossed the cell wall from entering the cell membrane?
Answer: Callose
6. Select the correct pair from the following options:
Junk genes ─ | The functional genes take part in the synthesis of protein |
Interferons ─ | The genetic scissors used to cut genes |
Genome ─ | The complete genetic material present in an organism |
Endorphins ─ | The proteins used for the treatment of growth disorders |
Answer: Genome ─ The complete genetic material present in an organism
7. Suitably arrange the information under the given headings:
- Evokes sensation
- Co-ordinates the repeated movements during walking and running
- Impulses from different parts of the body and transmitted to and fro the brain
- Co-ordinates the muscular activities and maintains equilibrium of the body
Brain | Spinal Cord |
Brain | Spinal Cord |
Evokes sensation | Co-ordinates the repeated movements during walking and running |
Co-ordinates the muscular activities and maintains equilibrium of the body | Impulses from different parts of the body and transmitted to and fro the brain |
8. Analyse the following illustration and answer the questions:
a. What proof of evolution does this illustration give?
b. Does the study of homologous organs give similar proof? How?
Answer: (a) According to the illustration given, it proves that different species that exist today share a common ancestor.
(b) Homologous organs are the organs from various animals that have the same structure but different functions. Now, by studying these organs, it becomes evident that there was a common ancestor for all these living beings. Comparative morphology also indicates proof of evolution.
9. Analyse the following statements related to certain diseases and give the reasons for each.
(a) In hepatitis, dark yellow colour appears in the white portion of the eyes and the nails.
(b) In diphtheria, the ash-coloured thick coating forms in the throat.
Answer: (a) When the flow of bile secreted by the liver is blocked, it gives rise to an increase in the level of the bile pigment, called bilirubin in the blood. This leads to dark yellow colour of the mucus membrane, nails and white portion of the eyes.
(b) Diphtheria is a severe bacterial infection that affects the mucous membranes of the throat and nose producing toxins, which destroy the cells of the mucus membrane. These cells that are destroyed by the toxins produce ash-coloured thick coating in the throat.
10. Observe the picture and answer the following questions:
a. Name the part indicated as (i)
b. How does myelin sheath form?
Answer: (a) The part indicated by (i) in the illustration is Axon.
(b) Myelin sheath: Axon of many neurons are surrounded by a series of cells called Schwann cells. The plasma membrane of these cells contains myelin, a white fatty material. Schwann cells wrap their plasma membrane around the axon, forming an insulated covering called the myelin sheath.
11. Analyse the table related to human chromosomes and arrange the column B in accordance with column A.
Sex chromosomes | 22 + X |
Somatic chromosomes | 44 + XY |
The chromosomes in sperms | 22 pairs |
The chromosomes in ovum | X, Y |
Sex chromosomes | X. Y |
Somatic chromosomes | 22 pairs |
The chromosomes in sperms | 22 + X , 22 + Y |
The chromosomes in ovum | 22 + X |
12. The functions of the cells in specific defence are illustrated below. Identify (i), (ii), (iii) and (iv)
Answer: (i) B- Lymphocytes
(ii) Matures in the Thymus glands
(iii) Stimulates other defence cells
(iv) Disintegrate the cell membrane of bacteria or kill them / stimulate other white blood cells, which will help to destroy the pathogens
13. Analyse the following statement and answer the questions :
"Though haemophilia is not completely curable, temporary relief can bring in."
(a) How can temporary relief be brought in?
(b) Why is complete cure not possible?
Answer: (a) Temporary relief for haemophilia is to receive replacement of the deficient protein by injecting it
(b) Complete cure for this is not possible, as it is a genetic disease
14. Observe the given steps related to the experience of taste and arrange them properly.
- Impulses reach the brain through the nerves.
- The taste detecting chemo receptors are stimulated.
- The substances reach the taste buds through saliva.
- Substances responsible for taste dissolves in saliva.
- Forms the experience of taste.
- Impulses form in the chemical receptors.
- Substances responsible for taste dissolve in saliva.
- The substance reaches the taste buds through saliva.
- The taste detecting chemo receptors are stimulated.
- Impulses form in the chemical receptors.
- Impulses reach the brain through the nerves.
- Forms the experience of taste.
15. Analyse the part of an illustration related to genetic engineering and answer the following questions:
(a) Add further steps and complete the illustration.
(b) Mention any other advantages of genetic engineering.
Answer: (a) Other steps that are added to complete the illustration related to artificially preparing Plasmid includes
- Insert DNA in bacterial cell.
- Provide a favourable medium for multiplication of bacteria.
- Bacteria produce inactive form of insulin.
- Produce active insulin
(b) Some advantages of genetic engineering are as given below:
- Increased supply of food having longer shelf life at reduced cost.
- Produce genetically modified plants and animals that can manufacture medicines.
- Gene therapy is used to cure genetic diseases.
- Used in Forensic and DNA tests.
16. The hybridisation process of a tall round seeded plant with a dwarf wrinkled seeded plant is illustrated below:
(a) Identify and fill (i) and (ii)
(b) What may be the characters that will appear in the plants produced as a result of the self-pollination of the first generation?
Answer: (a) (i) TR and (ii) tr
(b) Meanwhile, the characters that will appear in the plants produced as a result of the self-pollination of the first generation are given below:
- Tall plants with round seeds (TTRR, TTRr, TtRR, TtRr) .
- Tall plants with wrinkled seeds (TTrr, Ttrr).
- Dwarf plants with round seeds (ttRR, ttRr).
- Dwarf plants with wrinkled seeds (ttrr)
17. Write a short note which explains the mode of transmission and precautions of rat fever to include in a pamphlet preparing for an awareness programme.
Answer: Here are some mode of transmission of Rat fever mentioned below to be included in any pamphlet informing of an awareness programme:
- Rat fever affects both humans and other animals
- The infection is generally transmitted to humans by water that has been contaminated by animal urine, which comes in contact with unhealed breaks in the skin, the eyes, or with the mucous membranes
- Leptospira interrogans spreads under conditions of stagnant water, flood water, humidity, and proximity between man and beast
Meanwhile, the precautions for rat fever are also given:
- Keep the surroundings clean and avoid dumping decaying substances
- Eliminate the rats
- Wear long gloves and gumboot while working in fields and streams and while stepping into stagnant water, prevent the multiplication of rat
- Diagnose and start the treatment early for best results
- Preventive vaccination is also the most effective method to fight this disease
18. Analyse the illustration and answer the following questions ?
- Write the names of (i) and (ii)
- Are all accidental responses controlled by (iii)? Explain with an example.
Answer: (a) In the given figure (i) is Sensory neuron and (ii) is Inter neuron
(b) Not all of our accidental responses are controlled by the spinal cord (iii). When light falls on our eyes or any object moves towards our eye we normally blink our eyes. This response is a cerebral reflex, under the control of the cerebrum.
19. An illustration related to human evolution is given. Analyse it and answer the following questions:
- Write the names of the categories (i) and (ii)
- Mention the two important characteristics of organisms that belong to (ii).
- How does the comparative study of haemoglobin help to identify the evolutionary relationship between man and chimpanzee ?
Answer: (a) Category (i) from the image is Cercopithecoidea and (ii) is Hominoidea
(b) The two important organisms that belong to (ii) Hominoidea are the developed brains and the freely moveable hands
(c) A comparative study of haemoglobin explains how an ancestral single-function molecule gave rise to descending molecules with varied functions. Haemoglobin is the molecule in red blood cells responsible for giving blood its colour and for carrying oxygen throughout the body. New functions of metallo-porphyrin rings or a kind of molecular cage embedded in proteins were developed with the appearance of atmospheric oxygen. The presence of haemoglobin in both oxygen-needing and non-oxygen needing organisms also suggests the same evolutionary roots. Meanwhile, you can see that there is no difference in the number of amino acids in the chain of haemoglobin found in the man or chimpanzee.
20. Select the suitable items from the box and complete the table related to the hormone defects.
Pancreas | ____(i)______ | Diabetes | ____(ii)___ |
Hypothalamus | Vasopressin | ______(iii)______ | _____(iv)____ |
Pituitary | ____(v)___ | ____(vi)____ | Growth of the bones on the face and jaw |
- Somatotropin
- Diabetes insipidus
- Acromegaly
- Presence of glucose in urine
- Frequent urination
- Insulin
- Hindrance in proper physical and mental development
Answer: (i) Insulin
(ii) Presence of glucose in urine
(iii) Diabetes insipidus
(iv) Frequent urination
(v) Somatotropin
(vi) Acromegaly
21. Identify the gland indicated in the picture and answer the following questions:
(a) Name the hormone produced by the part indicated as (i), which slows down the action of defense cells.
(b) Name the two hormones produced by the part indicated as (ii). Give their functions.
(c) Write two important functions of aldosterone.
Answer: (a) The hormone produced by the part (i) Cortex is Cortisole, which slows down the action of defense cells
(b) Part (ii) indicated in the image is the medulla. Meanwhile, two non-steroid hormones produced by the adrenal gland are adrenaline (also called epinephrine) and noradrenaline (also called norepinephrine). Meanwhile, Adrenaline is often called the "stress hormone" as it is a major hormone secreted in response to stress. At the same time, the hormones – adrenaline and noradrenaline also serve as excitatory neurotransmitters in the sympathetic nervous system.
(c) In the meantime, the two primary and linked functions of aldosterone are given here:
- It helps to control the blood pressure or helps in blood pressure regulation
- It also helps with osmoregulation, that is the process of regulating the amounts of water and mineral salts in the blood
22. Explain how the body will react to the situations described below :
(a) A foreign antigen reaches one's blood.
(b) The components of vaccines enter the body
Answer: a) The defense activity of the recipient is stimulated when a foreign antigen reaches their blood. Then, the antigen in the blood will react with the antibody in the recipient's blood, thus resulting in clotting of the blood. Thus, we can conclude that a person cannot receive all types of blood. They can only receive the blood that matches correctly.
(c) Alternatively, when the components of vaccines enter the body, then it will act as the antigens that stimulate the defense mechanism of the body. Antibodies are also formed in the body against them, which are retained in the body. Later these antibodies protect the body from the pathogen that is responsible for the particular disease.
23. Redraw the picture given below. Identify the name indicated and label the parts.
(a) The part refracts light rays into the eye.
(b) The part that adjusts its size as the intensity of light varies.
(c) The part of Retina where plenty of photo receptors are seen.


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For some, the search for the "Lost City of Gold" — aka the Eldorado General Store — ends on the corner next to Corktown's historic Tiger Stadium.
Step inside and you'll most likely be greeted by owner and "Chief Trinketeer" Erin Gavle — a self-proclaimed gypsy who left corporate life to turn a knack for finding antiques, art, and vintage clothing into her dream job.
After graduating from Michigan State University with a degree in advertising, Gavle found herself bouncing back and forth from the East and West coasts, but felt her calling was to do something bigger and more creative.
She's collected treasures all her life, but never knew it would become her business.
"For a long time I was sort of a cheerleader for Detroit from afar," Gavle says.
She returned home for a wedding in 2013 and ended up staying three weeks longer than anticipated, and wound up discovering the Detroit she'd always been intrigued by as a little girl.
"I just kind of drove around and sat in coffee houses and soaked in what was happening," she says. "It was really important to me to sit in these different neighborhoods and actually experience what was happening down here. … I thought, 'Wow, I can actually move back home, potentially start my own business, and instead of talking about how great Detroit is, I can show people.' "
And show people she did. With the help of her real estate broker cousin, she tracked down the owner of a historic Corktown fixer-upper.
It took almost a year's worth of work (including the fact that there were no windows), but in July 2014 she opened up shop.
Eldorado General Store is housed in a late-19th century building that used to be a Detroit Tigers souvenir shop. It looks like a mini Flatiron building, and also happens to have a loft upstairs, where Gavle lives.
During the year of waiting for the building to be ready, Gavle did what she loves most — she took a road trip.
"I bought this really big sketchy van and drove across the country," she says. "I got most of the (store) inventory from that trip."
Inside the store, natural light pours through the large windows, putting a giant chandelier and all of Gavle's treasures on display.
"A lot of these things are souvenirs or memories that I had," she says. "They represent little pieces of happiness to me, and it's been really exciting to share those things with other people."
Every corner of the store is filled with hand-picked gems like old horseshoes, Tigers paraphernalia, men's and women's vintage clothing, handmade jewelry, locally made goods, and more. The one thing that brings every item together is a price tag that lists the city where Gavle discovered it.
"I like to juxtapose two extreme differences of Parisian elegance, and a very classy sophistication, but also a sort of rustic, Southwestern, bohemian sort of vibe," she says.
"I really love the Southwest … the deserts are super magical. I think everyone needs to go … and scream really loudly and dance, and soak in the magic and wildness."
Customers find items they never knew they needed, such as a perfect suede-fringed jacket Gavle found in Wyoming or crystals from Venice Beach. They also tend to wander around longer than anticipated, and Gavle comfortably interacts with them.
A vintage flag is one of the first things you're drawn to when you walk into the shop. Gavle is quick to tell the story of how she acquired it, why it has 45 stars, and that it was hand-sewn in 1907.
Gavle says what brought her back to Detroit is a lot like her view on finding the perfect vintage pieces. "I really embrace the character flaws; I think they tell a story," she says.
While many of her customers are locals, she also gets a lot of international traffic.
"I keep calling them extreme tourists because they're coming from Australia and Europe, and I get a lot of people from Toronto," she says. "It's almost like an anthropological study to really be able to ask these people questions like, 'Why are you here in Detroit?,' 'Is this for work or for fun?,' 'What brought you here?'… It's been really interesting to see the shift of mindset on Detroit through my customers."
Open 12-7 p.m. Tues.-Sun. 1700 Michigan Ave., Detroit; 734-664-8633. eldoradogeneralstore.com


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Legal Coworking 101: What Kind of Office Services Are Best for My Legal Practice?
A Closer Look at How an All-in-One Office Provider Can Help Grow Your New Legal Practice
So, you're newly at the helm of your very own legal practice and are looking for office services to take your firm to the next level – but what's next?
Look no further than Carr Workplaces Aon Center, an all-in-one office provider that boasts a plethora of efficient office services that will fuel the success of your growing practice.
By Carr Workplaces – July 6, 2021
Scalability is defined as, "the capacity to be changed in size or scale."
I.E., "The scalability of Carr Workplaces' various office services presents you with the ability to select a plan that best fits your firms' s exact requirements and allows your firm to grow."
So, what services are offered by the number one office provider for legal professionals and how does it fit what I'm looking for?
An all-in-one office provider can help to:
Create a more professional image for your firm.
Virtual offices are ideal for solo legal professionals and smaller firms looking to instantly establish a prestigious, professional presence, especially in Chicago.
Utilize a virtual business address at the iconic Aon Center, where your mail and packages are received by our professionally trained, on-site team. You can even combine your business address with our business phone service, which comes with your very own dedicated business phone number and professional call answering by our team.
Utilizing one of our various virtual office services is an ideal alternative to using your home address and cell phone number to send and receive business collateral.
Conduct client meetings in a professional setting.
Instead of meeting at a noisy, local coffee shop, conduct your client meetings in our private day offices or spacious meeting rooms.These well-appointed meeting spaces come with unrivaled prestige, hospitality, and a fully serviced experience that will impress the best of your clients.
All meeting rooms include complimentary Wi-Fi access, telephone service, and are available to rent by the hour or by the day.
Maximize your billable hours.
It's easy to get caught up in administrative tasks, especially when you are just starting your practice. Instead, focus on your billable hours and leave the rest to our professionally trained administrative team.
Whether you need assistance with copying, scanning, and binding documents, preparing a brief, or need a witness and notary to finalize client's paperwork, our team is available on an as needed basis.
Improve your focus.
An elevator ride to the 51st floor of the Aon Center will take you to your own private office with four walls, a lockable door, and wide corridors.
Your new fully furnished, private office includes high speed WiFi, phone service with unlimited local and domestic long-distance calling, complimentary conference room hours, unlimited black & white copies, prints, scan and faxes, as well as access to all the amenities in our Community Café. Yes, freshly ground Starbucks coffee is included too.
Working from a private office at Carr Workplaces Aon Center isn't just the ideal next step for a new law firm, it's the best next step.
While the possibilities and ways for your new or growing firm to flourish with Carr Workplaces are endless, one thing is for sure – it's that our service offerings are conducive to firms and practices of all sizes.
No matter your desired setup, request, or need, we'll be here with you each step of the way.
Additionally, Carr Workplaces is proud to offer you a complimentary week in a private office space at the prestigious Aon Center during regular business hours for the month of August.
Get Started Today:


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Firefox Tab Reloader not saving tab reload options anymore
On FF 120.0.1 and Tab Reloader 0.6.1
I have FF set up with 7 tabs as home page, 6 of the tabs have tab reloader set to reload ever 1 hour. This has worked fine for years, the tab reload for the 6 tabs were saved after restarting FF. I didn't have to go back and tell tab reloader to reload after restarting FF. Maybe once and a while one tab didn't get the reload saved on a restart, usually always the same one.
Now when I restart FF none of the tabs have saved the setting to reload every 1 hour.
This has been going on for the last 2 releases of FF updates and there hasn't been any updates for tab reloader. Does anyone know why this is happening, I haven't changed anything in settings. I did uncheck hardware acceleration to see if that would fix another issue, but tabs weren't reloading after restart prior to that change on hardware accelation.
כל התגובות (3)
The tab reload interval is remembered across restarts for me as long as "Open previous windows and tabs" is enabled. Older versions of Firefox behave the same.
You could try removing the extension, restarting the browser and then reinstalling it.
I did that will see how it works. It would stop reloading some tabs even if I just disabled it then re enabled it. Wouldn't stop reloading all 6, just maybe a couple. Anyway, I removed it, restarted FF and then downloaded again. Will see how things go.
Didn't make any difference, sometimes none of the tabs save the reload and sometimes all but 2 save the reload time. I do have "Open previous windows and tabs" as enabled which is the first one under the General setting.


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Each week, Dr. Buzz Mingin dives into the minds of doctors, actors, and family members to gain more insight on mental and physical health and how each guest navigates through their lifestyle. These conversations Dr. Buzz has with his guests are not to be taken as medical advice, but rather a way to gain a new perspective. If you are considering taking any of the input the guests give from any of the episodes, please contact a medical professional before doing so.
Hire Dr. Buzz to Speak


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Unauthorised item in the bagging area
Sunday 17 February 2013
Scott Fraser is part of the the Weatherall studios bunker complex. His Life Of Silence 12" on Bird Scarer Records last year was a Bagging Area favourite. There's nearly two hours of Scott Fraser djing at Clandestino, all throbbing bass, moody synths, kick drums, oscillating wobbles and more besides. Well worth sticking on to brighten your weekend or to top it off if it's been a good one.
Henri Gaudier-Brzeska was an sculptor who died during the First World War, which dates this photo to pre-1914 i.e. one hundred years ago. Somehow photography has collapsed time because this photo does not look a century old, does it?
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Back pain, neck pain, arm pain and shoulder pain are often blamed on the chair. I've worked with a lot of people who spend thousands of dollars buying fancy "ergonomic" chairs and still don't see any change. Sound familiar?
Check out your monitor. How close do you have to be to really see what is on the screen? Are you looking over the top of your glasses? Squinting? You may start your day with good intentions, "sit up straight" is a mantra you chant to yourself in the morning. By the time you start typing you find yourself with your chin jutted forward, nose moving closer to the screen. These are all signs that your monitor is not in the right place.
Front, center, and within arm's reach. Is that where your monitor is? No. Move it. Go on, give it a try and see if I'm right. Doesn't that feel better? Learn more.


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The tools and resources listed here can help material handling and logistics professionals make a big difference on their companies' bottom lines. Consider this first page of the MHM Buyers Guide as the starting point of your information gathering process.
This Buyers Guide will help you sift through and identify the most appropriate solutions to your needs. Listings are organized by product category and by company to make your job easier.
Even if you're not ready to make an investment right now, keep this Guide on your shelf throughout the coming year as a ready reference. You'll be reading about these products and solutions in every issue of the new Material Handling & Logistics magazine.


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An 'alien' hand found on a Brazilian beach, forty cattle mysteriously killed in Colorado, and an Indian man who had 187 coins removed from his stomach were among the weird and wondrous stories to cross our desk this week.
This past week saw news of a strange mystery unfolding in Colorado, where wildlife officials are stumped by an odd incident wherein a whopping forty cattle were killed under mysterious circumstances. The peculiar puzzle started in October when a rancher found that 18 of his animals had been killed by what he thought was a pack of wolves. However, as the seemingly standard case was investigated, authorities wound up scratching their heads when another 22 dead cattle were discovered. They were further perplexed when an exhaustive search turned up no sign of wolves in the area, leaving them to wonder what exactly killed all of the creatures.
'Alien' oddities found their way into the news this past week by way of two stories featuring unusual objects that seemed to come from out of this world. First, in Brazil, a couple walking along a beach found the nightmarish skeletal remains of an appendage that they likened to the hand of an extraterrestrial being. After their video of the unsettling remains went viral, a marine biologist suggested that the strange find had likely been part of a dolphin. Later in the week, an anomaly hunter looking for possible signs of ancient aliens in NASA images of Mars spotted an unusual formation that bears an uncanny resemblance to a toppled alien statue, complete with two eyes, a nose, a mouth, and curious-looking crown.
By far the most bizarre story of the week came to us from India, where doctors treating a man for abdominal pain discovered a staggering 187 coins in his stomach. The jaw-dropping case began when the unnamed patient was rushed to the hospital by his family after he had complained of a persistent internal ache that had left him bloated and vomiting. When medical personnel set about solving the problem, they were stunned to see that tests showed a massive mound of metal inside of him. Rushing him into surgery, doctors spent the next two hours removing a veritable treasure of 187 coins, which they later found out that, due to a psychiatric condition, the man had eaten over the last two or three months.
For more strange and unusual stories from the past week, check out the Coast to Coast AM website.


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Show rundown for 4/24/2004
ResumePat Tillman Obit
Pat Tillman, a former NFL player who gave up a 3 million dollar contract with the Cardinals to join the U.S. Army was killed this week in Afghanistan.
NBA Playoffs with Eric Neel
The NBA's first playoff round of 2004 is proceeding at lightning pace. No, check that...it has been proceeding like molasses on a February morning in Siberia. Eric Neel, a columnist for ESPN.com, keeps us up to date on the latest doings of the big guys in shorts.
Hard Times in The Big Easy
The New Orleans Hornets have fallen behind two games to none against the Miami Heat in the first round of the NBA Playoffs. That's the last place the Hornets expected to be at the start of this season. And, as Ron Schachter reports, some fear the team's reversal of fortune may keep the fans from swarming to Hornets games.
Mmmmmm... Donuts!
Allow us to reinforce a stereotype and present the World Cop Donut Eating contest.
Mr. Irrelevant
It's not often a good thing to be dead last. But it's a pretty good deal if you are "Mr. Irrelevant" the name given to the last overall pick in the annual NFL Draft. We'll visit with 2003's "Mr. Irrelevant", Ryan Hoag.
Women on High...Redux
After reading Rebecca Brown's book, "Women on High: Pioneers of Mountaineering," modern-day adventurer Alison Gannet was inspired to honor the women who first climbed some of the world's most difficult peaks. In the next few days, joined by the author and four other women, Gannet will don period costume and make her way up Mont Blanc, to experience first-hand the challenges early women mountaineers faced. We'll talk to Gannet from Chamonix, France.
Bill dips into the "Only A Game" mailbag.
The NFL Draft 2004 and More with Charlie Pierce
Bill Littlefield and "Only A Game" analyst Charlie Pierce discuss: Draft wackiness, Clarett's last gasp, and the death of Pat Tillman.
Extreme Croquet
Only A Game first heard of Extreme Croquet through tales of matches played on snow with rubber balls and composite mallets, since traditional cricket equipment would shatter in the bitter cold. It was no accident that Only a Game visited the extreme athletes on a recent warm spring day.
This program aired on April 24, 2004.


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Dean's Lunchtime Clinical Club - 10 October 2017 - Catherine Carty
Catherine Carty, Resident in Bovine Health Management, presented on Vagal Indigestion to a large crowd in VET114 this week. Catherine recently passed the European College of Bovine Health Management Board Exams and is now a European Specialist in Bovine Health Management. Catherine outlined that vagal syndrome is a common clinical presentation, but that there is not much in the literature on it. She began her talk by describing the highly specialist functions of the forestomachs - absorption, transport, VFA metabolism. Catherine went on to describe primary and secondary rumen contractions and what needs to happen for them to occur; she also highlighted what can interfere with these processes. Looking at the classification of vagal indigestion is not just an academic exercise, but is important for figuring out what's wrong.
Catherine then presented a case example from the UCD Veterinary Hospital involving a 5 year old Holstein/Friesian cow, 1 week calved, with a 2 day history of inappetance and intermittent bloating of the left abdomen, mildly distended on the left, quite alert and responsive. Having access to the equipment available in a University teaching hospital is key when working with such cases, and in this case the team carried out blood tests, completed an ultrasound on the reticulum where they found a noteworthy pattern of hypermotility, and x-rays were also taken which showed multiple foreign bodies and fluid/gas interface; it was deemed likely the cow had a reticular abscess. Abdominocentesis was attempted but there was scant amount of fluid and no sample gained. The problem list was then reviewed: abdominal distension, bradycardia, hypermotile reticulum, pain, blood abnormality explained by abscess, chronic inflammation and impaired rumen motility. The diagnosis given as a result of this was traumatic reticuloperitonitis with associated type 2 vagal syndrome.
Catherine detailed the discussion with the owner that followed on from the diagnosis. One option in these cases is rest/physical restriction of movement – rest is a recognized salvage treatment, but was deemed unlikely to work in this case. The animal was prepped for a left flank laparotomy with distal paravertebral block. The cranial abdomen was explored, and the team identified one large adhesion of reticulum to ventral body wall. A rumenotomy was performed with a 3 layer approach to ensure seal.
Hardware was retrieved, and the abscess in the medial reticular wall was drained. Catherine then completed the procedure with a double layer closure of the rumen; closure is very important to ensure the animal does not get an infection. Post-operative care involved rest and antibiotics. There was a slight improvement in the animal for two days after the surgery, however, after a week she was euthanized; she had continued to worsen, and was not eating at all. Catherine detailed that the prognosis in these cases depends on the level of vagal damage pre-surgery and the timing of events. A post-mortem revealed reticular abscess closely adhered to liver abscess. As this was the third such case for this particular herd, the owner was advised to put a magnet in the diet feeder. In concluding her presentation, Catherine highlighted that this was a reasonably common presentation in UCDVH; exposure to such cases in the Clinical Club setting can only be useful for our pre-clinical students.


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John McCarthy decided to start his business when his employer asked him to put a used part on a system and charge the customer as if that part was new. He quit the job on the spot. "When I got home, I realized what I had done...quit my job that supported my wife, daughter, and newborn son," John said. "My mother-in-law looked at me and said, 'You're a smart man, why don't you start your own business?'"
John started McCarthy Heating & Air Conditioning as a one-man, one-truck operation.
He has proudly served the Omaha, Nebraska area since 1970, where he quickly built valuable relationships with the residents in his community. With its humble beginnings, the company relied on on-time service and getting the job done right the first time to build their reputation.
In 2003, John became one of the first operating franchises under One Hour Heating & Air Conditioning and served as a model operation and training center for many future One Hour franchises.
Over the course of his career, John has been awarded numerous recognitions, including:
- Better Business Bureau's Integrity Award for Service Excellence
- Best Contractor to Work For in the Upper Midwest Region
- One Hour's Spirit Award
We are proud to have John as one of the founding members of the One Hour Heating & Air Conditioning family and know his accomplishments are far from over.


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"The press would have us believe that criminals can do what they like and then merrily sue all and sundry for the unfortunate consequences of those actions. Sadly for tabloid journalists this is simply not true as the Court of Appeal recently remind us in Joyce v O'Brien [2012] EWHC 1324 (QB), [2012] All ER (D) 202 (May). The case is a useful reminder of the rule often shortened to "ex turpi", namely that the court will not allow a party to profit from a loss arising from that party's own criminal or immoral activity."
New Law Journal, 27th June 2013
Source: www.newlawjournal.co.uk


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Armenia's T. Barseghyan (R) vies with Kazakhstan's Sergei Maliy during their qualifying match of FIFA World Cup 2018 in Yerevan, Armenia, March 26, 2017. Armenia won 2-0. (Xinhua/Gevorg Ghazaryan)
YEREVAN, Armenia, March 26 (Xinhua) -- Armenia beat the 10-man Kazakhstan 2-0 at home on Sunday in a 2018 FIFA World Cup qualifier.
Following their incredible 3-2 comeback win over Group E leaders Montenegro last November, Armenia manager Artur Petrosyan was forced to make an early substation following a third minute injury of Gevorg Ghazaryan.
The home team kept pressing the opponents in their own half of the field, but Kazakhstan maintained a clean sheet and even created one or two decent chances.
Kazakhstan's Sergiy Malyi received his second yellow on the 64th minute. It took only 9 minutes for Armenia to get the upper hand when Henrikh Mkhitaryan scored.
Just two minutes later, Aras Oezbiliz doubled the score for Armenia, which picked up its second win in the group and is now in fourth place with six points behind Poland, Montenegro and Denmark.
Armenia will face Montenegro next in June.


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by Jennifer Hartley, Director, Invest Newcastle
Newcastle is a city region that thrives on fresh ideas. We really did event the lightbulb and since then we have continued to innovate. A hub for smart, digital, and sustainable technologies our city finds itself a test bed for new products and services that are helping to tackle some of the world's most pressing economic and social challenges.
Renowned for our approach to private and public sector collaboration, we have one of the fastest growing tech clusters in the UK, five world-class universities and 50,000 students studying STEM subjects. City Fibre's £50 million full-fibre installation project will place us in the top tier of UK cities for connectivity. A new 25-mile high-capacity fibre network will give Newcastle the best connections to businesses in America and Europe.
Newcastle Helix is playing a significant role our position as a 'smart city'. This 24-acre development brings together industry leaders, businesses, and top researchers. It's home to the National Innovation Centre for Data (NICD) who support organisations to gain insight from their data and the Urban Observatory, who host the largest set of publicly available real time urban data in the UK. Though over 700 million data points with everything from bin sensors, waste, and air quality to flooding, and traffic pollution, they are helping to shape the future of our city.
Back in 2019, Newcastle picked up an award as the UK's smartest city. The award recognised our innovative use of technology to deliver responsive services more effectively and to make life more liveable for our citizens through better transport and cleaner air.
The same year we led a delegation to the Smart City Expo in Barcelona, where the private and public sector came together to showcase and share learning with other influencers and innovators. Businesses joining our delegation included Newcastle-based Urban Foresight, the only dedicated smart city consultancy in the UK, CityFibre who are installing game–changing gigabit speeds in our city, and Cisco who worked with us on developing the UK's smartest street in 2018. Our delegation was testament to the strength of our digital transformation and the collaborative nature of our business community.
Since then COVID-19 has changed life for people, businesses, and cities. We are all facing complex economic, social, political and cultural challenges that will significantly change the shape of our future. Businesses and researchers based in Newcastle Helix have been collaborating and using real–time data to continue to support our economy and help people live well during these challenging times.
Newcastle University's Urban Observatory team has been collecting evidence of the effects of measures introduced in response to COVID-19 and they have partnered with the NICD to develop a new web-based application that uses real-time data to check how easy it is to maintain social distancing in our city centre.
Data from cameras not only helps to keep people safe but it is helping to build customer confidence and support city centre businesses. NICD has also been working with the public sector to explore data–sharing across the region and explore how this can help cities prepare and plan for a crisis like COVID-19, ensuring effective responses to similar global and societal issues in the future.
Our talent and unique approach to data and intelligence is continuing to attract investors. Despite a difficult end to the financial year we saw a record number of businesses investing in our city, including the BBC who are setting up a new tech hub. They describe our city as a place actively looking for fresh and innovative ideas, one where they can deliver a new generation of data scientists.
Through the power of smart technology, strong leadership, and continued collaboration, we are reimagining our new world. Newcastle is not just a place for business, it's a place you can live well. Be part of it.
Newcastle Helix: A eco-system of innovation
Invest Newcastle: Strong leadership and global assets
Newcastle: A place to invest
Working across the world from Newcastle
Newcastle: A gigabit city
Newcastle: Helping people to live well
Invest Newcastle: Talent, quality of life and innovation
To find out more about Newcastle as a smart place to locate or grow your business email firstname.lastname@example.com


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Terrilyn VanGorder, PA is proudly affiliated with KTS Homes, a 20-year veteran custom luxury home builder, headquartered in Naples, Florida. Acclaimed as the premiere Southwest Florida construction firm, Scott Kish II, principal and lead architect also serves in the role of builder, with oversight of each project from conception to execution and finish. The firm excels at new, luxury custom builds on new property acquisitions or in pre-purchased parcels, and is a leader in total home renovations and remodeling projects. Exquisite homes are currently under construction by KTS Homes in the most desirable and exclusive communities of Naples Club Estates and Naples Reserve.
Whether your style is traditional, coastal contemporary, modern, or farmhouse chic, or if you want a unique home design yet to be conceived, one that mirrors your personality to a tee, KTS Homes can make it happen - delivering the unimaginable.


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About Stoneledge Animal Hospital
Our dedicated, experienced staff combines compassion with the latest in veterinary technology to provide the highest level of care possible for your pet.
Our Hospital Mission
We understand that a pet is part of the family, and from the moment your pet enters our hospital, he or she becomes part of our family, too. It's our hope to partner with you in giving your pet as many happy, healthy years with you as possible. Our top-of-line facility is equipped to handle every aspect of veterinary care from preventative medicine to emergency services. From new puppies and kittens to graying seniors, we'll be here for you and your pet over a lifetime.
The team at Stoneledge Animal Hospital is proud to be part of the Westbrook, ME community.


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Try the online quiz, reading, listening, and activities on grammar, spelling and vocabulary for this lesson on Frustration. Click on the links above or see the activities below this article:
Frustration is a terrible thing. In fact, it's a frustrating thing. Getting frustrated is one of life's biggest frustrations. I wish I didn't get frustrated, but there are so many things in life that are frustrating. I think the biggest thing recently is computers. Getting a new computer out of the box can be frustrating. Understanding how everything works is doubly frustrating. And then there are all the frustrations with programmes that freeze, web pages that don't open, and things you lose. I wonder why we get so frustrated. I think we could do things better if we relaxed and did everything slowly. I wonder if animals and birds get frustrated. I'm sure a lot of the things we humans do causes them a lot of frustration. |


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The University of North Alabama Knows the Importance of the Cabela's Collegiate Big Bass Bash Presented by Berkley
By Cody Levy
The University of North Alabama Bass Team is no stranger to hard work and success in the world of college fishing. Standing as the reigning two-time Cabela's School of the Year, the UNA Lions are once again on the hunt for their third consecutive Cabela's School of the Year title, and they know exactly how they plan to get it.
The 2016 Cabela's Collegiate Big Bass Bash Presented by Berkley is the first of three Cabela's Collegiate Bass Fishing Series events and are the only events throughout the season that count for double points towards the Cabela's School of the Year. UNA Senior and Team Vice President, Andrew Tate shed a little light on how he and the rest of the team plan to once again gain control of this year's Cabela's School of the Year rankings.
"We're definitely going to be sending a lot of teams to the Big Bass Bash this year. It's important to do well at the Cabela's Collegiate Bass Fishing Series events to stay in the hunt for the Cabela's School of the Year. The points you can gain at these events are crucial and especially at the Big Bass Bash. This is the season opener and it's important to start it off right," said Tate.
The Cabela's Collegiate Big Bass Bash Presented by Berkley offers anglers a different style tournament that focuses on one big bite rather than five and mental strategy, which the UNA Senior can only enjoy at this event.
"I like that there's no pressure to have five quality bites," said Tate. "It's different in that you can kind of relax in this format and there seems to be less pressure. I can slow down and focus on getting one big bite and I really like this style format. It's nothing but strategy and you can win just off of beating somebody else's strategy."
This is a year that UNA looks forward to, not only in tournaments and events, but within the club as well. Leaving a legacy for future generation club members has been a key moral that the upperclassmen of the team have wanted to instill and this year, they feel as though their plan is gaining traction.
"We're pumped about this season. We have a lot of new young guys that are excited, smart, and eager to learn," said Tate. "Not a lot of guys say they want to get beat by freshmen, but personally I wouldn't hate to see any of these guys beat me just to know that once I leave from the club, it will be in good hands."
When asked about the team's preparation and enthusiasm for the 2016 Cabela's Collegiate Big Bass Bash Presented by Berkley, Tate stated that "our whole team looks forward to this event. Some teams look forward to a certain circuit or event, but I think that the whole team really looks forward to the Big Bass Bash every year and Paris, Tennessee and the hospitality that we find at this event just makes us keep coming back every year."
To register for the 2016 Cabela's Collegiate Big Bass Bash Presented by Berkley and to get in on the opportunity to win hundreds of Cabela's School of the Year points, click HERE.
About the ACA
The Association of Collegiate Anglers, a division of Careco TV, is a sanctioning body developed to facilitate growth, development, and structure within competitive collegiate bass fishing. The ACA provides support to dozens of school operated regional events nationwide and owns the Cabela's Collegiate Bass Fishing Series, the largest participatory collegiate tournament circuit in the country. With dedicated collegiate fishing programming on several television networks, three nationally televised collegiate bass fishing events, and thousands of members, the ACA is the leader in competitive collegiate bass fishing. For more information on the ACA, or the Cabela's Collegiate Bass Fishing Series, visit www.CollegiateBassChampionship.com. For more information on Cabela's visit Cabelas.com, for more information on CarecoTV, visit www.carecotv.com.


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What Rolf Method of Malibu Clients are saying…
There are Rolf Practitioners, and then there are Rolf Practitioners. John Baier's powerful and methodical delivery of traditional Structural Integration is not to be missed. The difference in my body and the quality of my life from his work is incomparable with the work of others. John has achieved a real mastery of Ida Rolf's techniques. His ability to see structure, and create powerful remedy is magical. I recommend his work to all who want more comfort in their body and to anybody who wants to evolve to a higher level of physical efficiency and grace of movement.
Dan Bienenfeld, 35-Year Hellerwork Practitioner
Yup - magic again! I just woke up and the 8+ level pain I've been feeling in my neck for the past months is gone. As someone who is extremely active (cycle the hills of Malibu, a ski patrol for 23 years and a former bodybuilder), my body gets kinked into very painful episodes often. Since moving to Malibu 20 years ago, I found John and he's my never-fail-go-to-fix-it-guy. Every single time he works on me, the issue is solved. Whether I've had a weird fall on my paddleboard and pulled a deep, difficult to explain muscle in my pelvis, to ergonomic anomalies that happen from sitting in front of a computer all day, the fascial system seems to be the culprit and he knows what to do. John is an amazing practitioner who works miracles.
Allison Dutch, Dutch & Dutch Marketing
I have had bodywork all over world as I have toured doing shows & there is nothing on the planet like John's delivery of Ida Rolf's genius. I've done many Rolf "ten series" with John over the last 7 years and will do more in the future. The results are always life changing and with every series I feel like I get to the next level possible for my body as a skate boarder, musician, surfer and and life long martial artist. John empowers your life in way you cannot imagine and that is why he works on my family and all of my friends and fellow musicians & always will as long as I live.
DJ, Composer, Producer, Touring Artist and Co-Founder LMFAO
Have seen John for almost 20 years. After a session the sense of relaxation and peace is amazing. I sleep well for days. There used to be times I could not drive to work because the pain in my legs and lower back were so bad I would have to stop and get out of my car. Best thing to happen to me, better than any pain pills.
Bata Mataji, The Big American Dream Company
As a physician, acupuncturist, and patient with Multiple Sclerosis, I have experienced and practiced many modalities in the endless pursuit of self-improvement and healing. Dr. Rolf's Structural Integration methods have been a mainstay for me, clearing out new stresses in my body-mind while improving my posture and providing ease, flexibility, lightness of being, and youthfulness, even as I age. After decades of bodywork I can say unhesitatingly that John Baier is one of the very, very best there is. His work is thorough, satisfying and effective. Personally, he is caring, intelligent, sensitive and a delight to work with. His therapeutic bag of tricks is enormous; he often does something no one else seems to know about and Wow! – Suddenly I'm released from some long-standing body issue that I had previously accepted as unfixable. John is simply wonderful.
Eliot Ivanhoe, MD, M.Ac.
As a mature formally competitive multidisciplinary female athlete (equine, surf, bike, run & ski) I am ever so grateful to have the opportunity to work with John regularly. I had my first 10 series 25 years ago, and have worked with many Rolf practitioners over the years and John is the best. I appreciate his intuitive understanding and his willingness to work with me to achieve my goals.
I am currently working through a TEN series of sessions which has brought total relief from chronic pain. It has also provided a deep new awareness in my body, increased breath capacity and opened my core. All critical for the level of competition and mastery I require in my activities. Very grateful for the pain relief & John's ability to keep my body functioning at it's highest level possible.
Sarah B
I thought I needed knee surgery because I could hardly walk. In spite of regular workouts, stretching and Pilates I saw no improvement. As I worked with John I realized to my horror that over many years my feet, shins, knees, upper legs and pelvis had all become rigid and locked. Over several ten series my whole body changed dramatically. I felt my "peg" leg become free, loose and comfortable. It was like having a teen leg again, and young knees. When we went back to Hawaii, we went up and down the Diamond Back trail. I realized when I got down that my leg had not bothered me at all, I called John and cried.
Melanie Flamenio
I discovered John Baier over ten years ago when deep tissue and sports massage did not work to relieve my overexerted muscles, tendons, ligaments and joints. I did a ten series and there is no doubt that John is a master of this manual therapy craft. His knowledge of the body brings blessed relief, and long-lasting change.
Nina Greenberg, Triathlete
Great Rolf practitioners are rare, and genuine traditional structural integration is getting harder & harder to find. Ida's work has become watered down & poorly delivered in many quarters. I am a certified advanced Rolfer and have known John since we took a class together 18 years ago. It takes many different aspects of a healthy human to deliver this work. John is the man, his work is amazing & powerful and we are lucky he is here. Go see him today.
Jeffrey Bohms, Certified Advanced Rolfer
After seeing other Rolf practitioners, I finally discovered John and understood what all the fuss is about. John's slow, deep, traditional manual therapy style is detail oriented and so, so extremely effective. People think Dr. Rolf's work hurts, in fact the opposite is true, the experience of working with John while occasionally momentarily painful is to feel the true ecstasy of years of painful suffering leaving your body for good. John is non-judgmental and kind and ALWAYS, ALWAYS gets the job done. My son now 19 has worked with John since he was 10 years old, as has my husband. John is in a category by himself, and we look forward to every session, several hours or more at a time are best. We would not want to live without him and I don't know what we will do if he ever retires.
Linda Hart, Mother
I had suffered for seven years with neck and back pain. I am an aerialist and do extremely intense workouts. I tried PT, Shiatsu, traditional massage, acupuncture, epidural, and even had a Doctor stab me with hypodermic needles filled with lidocaine in a process called "needling." The next step was to fuse my nerves to my spine with surgery! In a last-ditch effort to not have the surgery, I found John and the Rolf Method. After just two sessions, I had the most freedom of movement I've had in years. Over the ten series of sessions, the knots & movement restrictions I lived with like unwelcome in-laws have faded into the background. I am doing trapeze work again with no pain. John is skillful and knowledgeable. I recommend John to any extreme athlete who is muscle bound or anyone with chronic pain. Thank you, John, for giving me the lasting freedom of motion once again!
Heidi K
Sorry to sound like a televangelist, but I am HEALED! I came to Malibu for a 3 day yoga retreat and knew it was going to be tough going the first day. I have had hip issues for the last year and have been to orthopedists, doctors & chiropractors, and done specific training for this injury…all these helped somewhat, but not enough. After 90 minutes with John my hip completely opened up. I have passed his sign 100 times…so glad I finally came in to see him. If you have not tried his work….it's time.
Barbara H
I have worked with John for over ten years and have done Dr. Ida Rolf's full "ten series" with John several times. This progressive and powerful method of sequentially freeing up the fascial layers in the body truly creates results every session, and genuine lasting change over time. Dr. Rolf once said her work is something two people do together. It is hard to understand till you have had Rolf Manual Therapy the active role the receiver has. I have come to this awareness with John's work: John is a powerful facilitator in anyone's health, and I am an equally integral part in charge of my healing process. As an adult living with HIV, and now in my 50's I intend to always maintain the same kind of active life style I have always had. John has and continues to aide me in that goal through his work. John's bodywork is the best gift you can give yourself. John is terrific, dedicated and unique in his approach. Thank you John, as a friend and teacher. Namaste
Greg Louganis, 8 Gold Medal Winner Olympic Diver
John is a master listener to the body--where it's stuck, what it needs, and how to speak to it. His brilliant hands know exactly how to restore vivid function to structures that were just hanging out and taking a back seat on the ride.
There is an elegance, a patience, a deliberation and a grace to every single one of the healing gestures of John's Rolf Method bodywork. It is a poetry of physical restoration that will do nothing less than have you re-designing your concept of yourself as you suddenly inhabit a body that invites you to be MORE.
Life is movement, and when we can no longer move, our lives are over. This radiant work is nothing short of a reclamation of your birthright to be fully alive with that dazzling combination of both lightness and power that gives movement ease and embodiment its meaning. It is an energetic talisman that will set you up - like wow!! - for the next chapter of your life, whether you've been longing for it--or avoiding it.
In pain? In a pit? At a crossroads? Arising? John's work is the perfect healing gift, dialogue, undertaking for a profound sequence of transformation that will absolutely change your life.
Thank you, John, for delivering your gift!
Daphne Rose Kingma, Author (Comping Apart, The Future of Love, Ten Things To Do When Your Life Falls Apart, The Magical World of Madame Meiter - ASpiritual Fairy Tale for Adults)
I had a dropped foot and my neck and back were killing me. After multiple CT scans the doctors insisted they wanted to operate. The better choice was seven hundred dollars of weekly sessions (cheaper than my surgery co-pay) over several months with John and I am now back to hiking, biking and pain free living. I have had other deep tissue work over the last 15 years and John is unequivocally the best.
John Ingram, John Ingram Construction
By the time the first of a series of sessions was finished I felt like a different person. I felt entirely tension free, totally relaxed, my posture was upright again, and my neck had full range motion again. John is a miracle worker. I have had hundreds of sessions of bodywork over the course of my life – but nothing like this. I've even had "Rolf Method Work" but now I know what Ida's work is really all about. Consider yourself lucky if you get the opportunity to experience a session with John. He is amazing!
Stacy Cox, Therapist
I am so happy John came into my life. After 3 sessions I have had a dramatic transformation. I am 22 years old and have experienced over 10 years of migraines and severe neck and lower back pain. I have tried every kind of massage and nothing comes close to a Rolf Method session with John. He locates exactly where the root of the problem is coming from and works hard to eliminate the pain. The relief is not only instant it is long lasting. My first session I came to him after my lower back was in a severe spasm and I could barely move. After that session I have not had any lower back pain whatsoever (which is amazing as I sit at a desk all day).
My last 2 sessions I came in with my regular migraine and after ten minutes of him working on my scalp the pain is completely relieved and I left feeling clearer than ever. I can honestly say this is the best bodywork experience I have ever had as well as the most effective healing experience for my entire body.
Nicole C
Seriously amazing. I just can't even express what a life changer this is. I've had this chronic back & hip pain that has kept me from doing so many activities I enjoy. I just did my first session with John and I seriously walked out of his office pain free. He is incredibly knowledgeable in this field. I highly recommend him to anyone who has pain they want to work their way out of.
John worked his magic of Ida Rolf's Structural Integration method on my shoulder injury after a motorcycle accident. He is knowledgeable, professional and a wonderful human being ready to help with any injury or problem there may be. Thanks to John my shoulder has been finally relieved of constant pain and my mobility has significantly improved. I strongly recommend John to anyone looking for a highly skilled and authentic Rolf Practitioner.
Adriana S
I am a 22-years-old woman and have experienced over 10 years of migraines and severe neck and lower back pain. I have tried every form of bodywork and nothing even came close to a single Rolf Method session with John! After 3 sessions my life has changed dramatically. John locates exactly where the root of the issue is coming from and works hard to eliminate the pain. The relief that John work provides is not only instant, it is lasting and life changing.
Ashley A.
I have finally found the best Traditional Rolf Method practitioner and it is John. I am a huge fan of Rolfing. Over the years it has worked better for me than any other kind of treatment for back & hip problems as well as moving much more freely for sports and other forms of exercise, including a better posture. I have been to the top Rolf practitioners since the early 90s. John is the very best and I am so happy to have found him. I look for the Traditional Form of Structural Integration that really works, and John is it!! A practitioner like John is very hard to find and his is nice too! Thanks for being there for us.
Lori S
An incredibly talented practitioner, John has restored my flexibility with one powerful ten series, a dramatic life change for the better. I recommend you visit John for a series for one of the best series of treatments you will ever have received. It's been a long time since I've felt this good, and I have a new spring in my step.
Glen, Chiropractor


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Adolescents, Antibodies, and Cows – More Highlights from the IAS Conference on HIV Science
July 25, 2017 - HIV.gov Blog
TOPICS: NIAID, NIH, Prevention, Research, Women & Girls, Youth
New research findings were shared today at the International AIDS Society Conference on HIV Science (IAS 2017) in Paris. To learn about some of these developments, we caught up again with NIH's Dr. Carl Dieffenbach and Anne Rancourt in a Facebook Live event. Dr. Dieffenbach is the Director of the Division of AIDS at the National Institute of Allergy and Infectious Diseases (NIAID), and Ms. Rancourt is NIAID's Communications Section Chief. View their conversation below or on the HIV.gov Facebook page...[READ MORE]


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Go to new experiments and select the the template you wish to use.
Give the experiment a name and select a recorder type for your experiment. Webcam for testing with an online panel or Hardware for central location testing (at your office, outside the store or perhaps at the mall).
You are now ready to edit the template. Hit the "Design" button in the bottom right corner to get started.
Screening participants
The template begins with a couple of screening questions commonly used in packaging studies. Make sure to update them to fit your case before you begin fielding. For example, by changing [Product Category] to milk or liquid hand soap.
Hit the arrow in the corner to open the view below, then hit the edit button to update the question.
Explanation of the screen-out logic in the example above:
- Participants that do not select [Brand A, Your brand] will not move to the next question/task. They will be screened out.
- Participants that select [Brand A, Your brand] and additional brand/-s will move to the next question/task. They will not be screened out.
- None of the above cannot be combined with other choices, participants will be screened out.
By enabling Screen-out you can control and define your target audience. You are free to remove or add your own questions to the template. Just be mindful of the total number of questions; the more specific your target is the harder it will be to find your audience.
The first two questions regarding gender and age could be useful even without screen-out enabled. This will allow you to split your data based on age groups and/or gender.
Giving short and simple to understand instructions is key when it comes to webcam eyetracking. The goal is to get the participants through the instructions as soon as possible; to maximize the probability of successful eyetracking recordings for your experiment.
What should your instruction be? Consider your market strategy. Who is your target audience? What do you want to achieve or measure? Brand recall? Brand recognition? Salience?
There are three types of instructions that work well in a Sticky shelf test:
- Look at the shelf with or without intent (settings: 7 or 10 sec, advance on time)
- Click on the product you want to purchase (Settings: 10 or 15 sec, advance on click or time)
- Find and click on a specific brand/product. (Settings: 10 or 15 sec, advance on click or time)
Building your shelf
Placing your designs in a shelf reveals how well your design versions stand out amongst competitors and gives an indication of visual saliency.
Click on Add items to select your images from your folder and start building.
Tips and tricks
- Add PNG files that don't have any background, for a realistic look in the shelf.
- Crop your image to remove as much of the empty background as possible. This ensures that the AOI is focused on the product and not collecting irrelevant data.
- Keep the file size for each added pack as low as possible. (more items on the shelf means more time to load on the participants screens)
- Consider the number of items and rows you want in the shelf. The shelf and items inside it will be fitted to the participants screen. A 3000x3000 px image might be presented as 900x900 px once in a live shelf depending on number of rows and columns. Sticky will still need to load the full 3000x3000 px, taking longer to load the total shelf.
Packaging in isolation
A/B test different design versions to evaluate size, dimension and placement of key elements in your design.
Upload one or multiple designs to your experiment and randomly show each participant from your target audience one of the designs. recommended exposure is 5 or 7 seconds.
Right after the exposure the template follows up with a simple survey question to measure visual appeal, relevance and purchase intent.
Use the Link to Media drop down list to link the respondents answers to the image randomly seen.


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Independent Thinking: The Influence of Pitchfork
As someone who listens to a large amount of music, I am always looking for something that is a bit different. Trying to find music that doesn't sound like something I have heard before is a difficult task, but with the Internet, it has become somewhat less so.
Pitchfork Media, a website that is familiar to most independent music fans, has played a large role in influencing the type of music that I like today. The website certainly does have its quirks, reviewing albums in a fashion that many would find irritating. I, however, defend Pitchfork for a variety of reasons, even though I acknowledge much of the website's music is too obscure for people to enjoy.
Pitchfork Media is notorious for its harsh critics; chances are that your favorite band or artist has been criticized on their website many a time. Often, Pitchfork will review an album and give it a rating of 0.0. Many critics say that Pitchfork's reviews are publicity stunts and they hold little to no truth whatsoever. The reality of it is that Pitchfork reviews contain the individual biases of the writers in addition to the bias of the site, which favors lo-fi and independent music over almost all else.
Pitchfork supports artists such as LCD Soundsystem, The XX, The Very Best and Deerhunter, just to name a few. Although I can disagree with what Pitchfork says often, I cannot deny that they love the same bands I do. My musical taste will be linked with the site for quite a while, whether I like it or not. That is not to say that I never disagree with what they put on their site, however.
Pitchfork seems to have gotten away from its exclusively independent roots. One of the reviews that received the most hits on Pitchfork of 2010 was that of Kanye West's My Beautiful Dark Twisted Fantasy. The website gave the album a perfect ten (a rarity on the Pitchfork scale), describing the album as "a blast of surreal pop excess that few artists are capable of creating, or even willing to attempt."
The site is certainly worthwhile for those looking for new music and the pitchfork.tv section offers great videos and original content. It certainly has made its mark in an age where music popularity is controlled in large part by the Internet. As a traditional radio station, Pitchfork would likely fail because it would not play most of the popular music other radio stations play to get listeners. Instead, it would play an obscure variety of mainstream rap (Gucci Mane, Kanye West), alternative electronica (Animal Collective, Tanlines) and minimalistic pop (The XX), all of which have fan bases that are mutually exclusive for the most part.
Pitchfork has a way of reviewing albums in a fashion that always seems as if it is too harsh on the artists, yet they always back up their claims in a way that makes us think twice about the music we are listening to and what makes it special or likable. Check out the site and you will see things differently; I promise.