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Parcopa Prescribing Information
Package insert / product label
Generic name: carbidopa and levodopa
Dosage form: tablet, orally disintegrating
Drug class: Dopaminergic antiparkinsonism agents
Medically reviewed by Drugs.com. Last updated on Mar 25, 2024.
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Parcopa Description
PARCOPA® (carbidopa and levodopa orally disintegrating tablets) is a combination of carbidopa and levodopa for the treatment of Parkinson's disease and syndrome. PARCOPA® is an orally administered formulation of carbidopa and levodopa which rapidly disintegrates on the tongue and does not require water to aid dissolution or swallowing.
Carbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 244.24. It is designated chemically as (–)-L-α-hydrazino-α-methyl-ß-(3,4-dihydroxybenzene) propanoic acid monohydrate. Its empirical formula is C10H14N2O4∙H2O, and its structural formula is:
Tablet content is expressed in terms of anhydrous carbidopa which has a molecular weight of 226.23.
Levodopa, an aromatic amino acid, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 197.2. It is designated chemically as (–)-L-α-amino-ß-(3,4-dihydroxybenzene) propanoic acid. Its empirical formula is C9H11NO4, and its structural formula is:
PARCOPA® is supplied as tablets in three strengths:
PARCOPA® 25/100, containing 25 mg of carbidopa and 100 mg of levodopa.
PARCOPA® 10/100, containing 10 mg of carbidopa and 100 mg of levodopa.
PARCOPA® 25/250, containing 25 mg of carbidopa and 250 mg of levodopa.
Inactive ingredients are aspartame, citric acid, crospovidone, magnesium stearate, mannitol, microcrystalline cellulose, natural and artificial mint flavor and sodium bicarbonate. PARCOPA® 10/100 and 25/250 also contain FD&C blue #2 HT aluminum lake. PARCOPA® 25/100 also contains yellow 10 iron oxide.
Parcopa - Clinical Pharmacology
Parkinson's disease is a progressive, neurodegenerative disorder of the extrapyramidal nervous system affecting the mobility and control of the skeletal muscular system. Its characteristic features include resting tremor, rigidity, and bradykinetic movements. Symptomatic treatments, such as levodopa therapies, may permit the patient better mobility.
Mechanism of Action
Current evidence indicates that symptoms of Parkinson's disease are related to depletion of dopamine in the corpus striatum. Administration of dopamine is ineffective in the treatment of Parkinson's disease apparently because it does not cross the blood-brain barrier. However, levodopa, the metabolic precursor of dopamine, does cross the blood-brain barrier, and presumably is converted to dopamine in the brain. This is thought to be the mechanism whereby levodopa relieves symptoms of Parkinson's disease.
When levodopa is administered orally it is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system. For this reason, large doses of levodopa are required for adequate therapeutic effect and these may often be accompanied by nausea and other adverse reactions, some of which are attributable to dopamine formed in extracerebral tissues.
Since levodopa competes with certain amino acids for transport across the gut wall, the absorption of levodopa may be impaired in some patients on a high protein diet.
Carbidopa inhibits decarboxylation of peripheral levodopa. It does not cross the blood-brain barrier and does not affect the metabolism of levodopa within the central nervous system.
The incidence of levodopa-induced nausea and vomiting is less with carbidopa and levodopa than with levodopa. In many patients, this reduction in nausea and vomiting will permit more rapid dosage titration.
Since its decarboxylase inhibiting activity is limited to extracerebral tissues, administration of carbidopa with levodopa makes more levodopa available for transport to the brain.
Carbidopa reduces the amount of levodopa required to produce a given response by about 75 percent and, when administered with levodopa, increases both plasma levels and the plasma half-life of levodopa, and decreases plasma and urinary dopamine and homovanillic acid.
The plasma half-life of levodopa is about 50 minutes, without carbidopa. When carbidopa and levodopa are administered together, the half-life of levodopa is increased to about 1.5 hours. At steady state, the bioavailability of carbidopa from carbidopa and levodopa tablets is approximately 99% relative to the concomitant administration of carbidopa and levodopa.
In clinical pharmacologic studies, simultaneous administration of carbidopa and levodopa produced greater urinary excretion of levodopa in proportion to the excretion of dopamine than administration of the two drugs at separate times.
Pyridoxine hydrochloride (vitamin B6), in oral doses of 10 mg to 25 mg, may reverse the effects of levodopa by increasing the rate of aromatic amino acid decarboxylation. Carbidopa inhibits this action of pyridoxine; therefore, PARCOPA® can be given to patients receiving supplemental pyridoxine (vitamin B6).
Indications and Usage for Parcopa
PARCOPA® is indicated in the treatment of the symptoms of idiopathic Parkinson's disease (paralysis agitans), postencephalitic parkinsonism, and symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication and/or manganese intoxication. PARCOPA® is indicated in these conditions to permit the administration of lower doses of levodopa with reduced nausea and vomiting, with more rapid dosage titration, with a somewhat smoother response, and with supplemental pyridoxine (vitamin B6).
In some patients, a somewhat smoother antiparkinsonian effect results from therapy with carbidopa and levodopa than with levodopa. However, patients with markedly irregular ("on-off") responses to levodopa have not been shown to benefit from carbidopa and levodopa therapy.
Although the administration of carbidopa permits control of parkinsonism and Parkinson's disease with much lower doses of levodopa, there is no conclusive evidence at present that this is beneficial other than in reducing nausea and vomiting, permitting more rapid titration, and providing a somewhat smoother response to levodopa.
Certain patients who responded poorly to levodopa have improved when carbidopa and levodopa was substituted. This is most likely due to decreased peripheral decarboxylation of levodopa which results from administration of carbidopa rather than to a primary effect of carbidopa on the nervous system. Carbidopa has not been shown to enhance the intrinsic efficacy of levodopa in parkinsonian syndromes.
In considering whether to give PARCOPA® to patients already on levodopa who have nausea and/or vomiting, the practitioner should be aware that, while many patients may be expected to improve, some do not. Since one cannot predict which patients are likely to improve, this can only be determined by a trial of therapy. It should be further noted that in controlled trials comparing carbidopa and levodopa with levodopa, about half of the patients with nausea and/or vomiting on levodopa improved spontaneously despite being retained on the same dose of levodopa during the controlled portion of the trial.
Nonselective monoamine oxidase (MAO) inhibitors are contraindicated for use with PARCOPA®. These inhibitors must be discontinued at least two weeks prior to initiating therapy with PARCOPA®. PARCOPA® may be administered concomitantly with the manufacturer's recommended dose of an MAO inhibitor with selectivity for MAO type B (e.g., selegiline HCl) (See PRECAUTIONS, Drug Interactions).
PARCOPA® is contraindicated in patients with known hypersensitivity to any component of this drug, and in patients with narrow-angle glaucoma.
Because levodopa may activate a malignant melanoma, PARCOPA® should not be used in patients with suspicious, undiagnosed skin lesions or a history of melanoma.
When PARCOPA® (carbidopa and levodopa orally disintegrating tablets) is to be given to patients who are being treated with levodopa, levodopa must be discontinued at least twelve hours before therapy with PARCOPA® (carbidopa and levodopa orally disintegrating tablets) is started. In order to reduce adverse reactions, it is necessary to individualize therapy. See DOSAGE AND ADMINISTRATION section before initiating therapy.
The addition of carbidopa with levodopa in the form of PARCOPA® reduces the peripheral effects (nausea, vomiting) due to decarboxylation of levodopa; however, carbidopa does not decrease the adverse reactions due to the central effects of levodopa. Because carbidopa permits more levodopa to reach the brain and more dopamine to be formed, certain adverse CNS effects, e.g., dyskinesias (involuntary movements), may occur at lower dosages and sooner with PARCOPA® than with levodopa alone.
Levodopa alone, as well as PARCOPA®, is associated with dyskinesias. The occurrence of dyskinesias may require dosage reduction.
As with levodopa, PARCOPA® may cause mental disturbances. These reactions are thought to be due to increased brain dopamine following administration of levodopa. All patients should be observed carefully for the development of depression with concomitant suicidal tendencies. Patients with past or current psychoses should be treated with caution.
PARCOPA® should be administered cautiously to patients with severe cardiovascular or pulmonary disease, bronchial asthma, renal, hepatic or endocrine disease.
As with levodopa, care should be exercised in administering PARCOPA® to patients with a history of myocardial infarction who have residual atrial, nodal, or ventricular arrhythmias. In such patients, cardiac function should be monitored with particular care during the period of initial dosage adjustment, in a facility with provisions for intensive cardiac care.
As with levodopa, treatment with PARCOPA® may increase the possibility of upper gastrointestinal hemorrhage in patients with a history of peptic ulcer.
Neuroleptic Malignant Syndrome (NMS)
Sporadic cases of a symptom complex resembling NMS have been reported in association with dose reductions or withdrawal of therapy with carbidopa and levodopa. Therefore, patients should be observed carefully when the dosage of PARCOPA® is reduced abruptly or discontinued, especially if the patient is receiving neuroleptics.
NMS is an uncommon but life-threatening syndrome characterized by fever or hyperthermia. Neurological findings, including muscle rigidity, involuntary movements, altered consciousness, mental status changes; other disturbances, such as autonomic dysfunction, tachycardia, tachypnea, sweating, hyper- or hypotension; laboratory findings, such as creatine phosphokinase elevation, leukocytosis, myoglobinuria, and increased serum myoglobin have been reported.
The early diagnosis of this condition is important for the appropriate management of these patients. Considering NMS as a possible diagnosis and ruling out other acute illnesses (e.g., pneumonia, systemic infection, etc.) is essential. This may be especially complex if the clinical presentation includes both serious medical illness and untreated or inadequately treated extrapyramidal signs and symptoms (EPS). Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever, and primary central nervous system (CNS) pathology.
The management of NMS should include: 1) intensive symptomatic treatment and medical monitoring and 2) treatment of any concomitant serious medical problems for which specific treatments are available. Dopamine agonists, such as bromocriptine, and muscle relaxants, such as dantrolene, are often used in the treatment of NMS, however, their effectiveness has not been demonstrated in controlled studies.
As with levodopa, periodic evaluations of hepatic, hematopoietic, cardiovascular, and renal function are recommended during extended therapy.
Patients with chronic wide-angle glaucoma may be treated cautiously with PARCOPA® provided the intraocular pressure is well controlled and the patient is monitored carefully for changes in intraocular pressure during therapy.
Dopaminergic agents, including levodopa, may be associated with somnolence and very rarely episodes of sudden onset of sleep. In some cases, these episodes may occur without awareness or warning during daily activities. Patients must be informed of this and advised to exercise caution while driving or operating machines while being treated with dopaminergic agents, including levodopa. Patients who have experienced somnolence and/or an episode of sudden sleep onset must refrain from driving or operating machines (see Information for Patients).
Epidemiological studies have shown that patients with Parkinson's disease have a higher risk (2- to approximately 6-fold higher) of developing melanoma than the general population. Whether the increased risk observed was due to Parkinson's disease or other factors, such as drugs used to treat Parkinson's disease, is unclear.
For the reasons stated above, patients and providers are advised to monitor for melanomas frequently and on a regular basis when using PARCOPA® for any indication. Ideally, periodic skin examinations should be performed by appropriately qualified individuals (e.g., dermatologists).
Information for Patients
Phenylketonuric patients should be informed that PARCOPA® contains phenylalanine 3.4 mg per 25/100 orally disintegrating tablet, 3.4 mg per 10/100 orally disintegrating tablet, and 8.4 mg per 25/250 orally disintegrating tablet.
Patients should be instructed not to remove PARCOPA® Tablets from the bottle until just prior to dosing. With dry hands, the tablet should be gently removed and immediately placed on the tongue to dissolve and be swallowed with the saliva.
The patient should be informed that PARCOPA® is an immediate-release formulation of carbidopa and levodopa that is designed to begin release of ingredients within 30 minutes. It is important that PARCOPA® be taken at regular intervals according to the schedule outlined by the physician. The patient should be cautioned not to change the prescribed dosage regimen and not to add any additional antiparkinson medications, including other carbidopa and levodopa preparations, without first consulting the physician.
Patients should be advised that sometimes a "wearing-off" effect may occur at the end of the dosing interval. The physician should be notified if such response poses a problem to lifestyle.
Patients should be advised that occasionally, dark color (red, brown, or black) may appear in saliva, urine, or sweat after ingestion of PARCOPA®. Although the color appears to be clinically insignificant, garments may become discolored.
The patient should be advised that a change in diet to foods that are high in protein may delay the absorption of levodopa and may reduce the amount taken up in the circulation. Excessive acidity also delays stomach emptying, thus delaying the absorption of levodopa. Iron salts (such as in multi-vitamin tablets) may also reduce the amount of levodopa available to the body. The above factors may reduce the clinical effectiveness of the levodopa or carbidopa and levodopa therapy.
Patients should be alerted to the possibility of sudden onset of sleep during daily activities, in some cases without awareness or warning signs, when they are taking dopaminergic agents, including levodopa. Patients should be advised to exercise caution while driving or operating machinery and that if they have experienced somnolence and/or sudden sleep onset, they must refrain from these activities. (See PRECAUTIONS: General.)
There have been reports of patients experiencing intense urges to gamble, increased sexual urges, and other intense urges, and the inability to control these urges while taking one or more of the medications that increase central dopaminergic tone and that are generally used for the treatment of Parkinson's disease, including PARCOPA®. Although it is not proven that the medications caused these events, these urges were reported to have stopped in some cases when the dose was reduced or the medication was stopped. Prescribers should ask patients about the development of new or increased gambling urges, sexual urges or other urges while being treated with PARCOPA®. Patients should inform their physician if they experience new or increased gambling urges, increased sexual urges, or other intense urges while taking PARCOPA®. Physicians should consider dose reduction or stopping the medication if a patient develops such urges while taking PARCOPA®.
Laboratory Tests
Abnormalities in laboratory tests may include elevations of liver function tests such as alkaline phosphatase, SGOT (AST), SGPT (ALT), lactic dehydrogenase, and bilirubin. Abnormalities in blood urea nitrogen and positive Coombs test have also been reported. Commonly, levels of blood urea nitrogen, creatinine, and uric acid are lower during administration of carbidopa and levodopa than with levodopa.
Carbidopa and levodopa may cause a false-positive reaction for urinary ketone bodies when a test tape is used for determination of ketonuria. This reaction will not be altered by boiling the urine specimen. False-negative tests may result with the use of glucose-oxidase methods of testing for glucosuria.
Cases of falsely diagnosed pheochromocytoma in patients on carbidopa and levodopa therapy have been reported very rarely. Caution should be exercised when interpreting the plasma and urine levels of catecholamines and their metabolites in patients on levodopa or carbidopa and levodopa therapy.
Drug Interactions
Caution should be exercised when the following drugs are administered concomitantly with PARCOPA® (carbidopa and levodopa orally disintegrating tablets).
Symptomatic postural hypotension has occurred when carbidopa and levodopa was added to the treatment of a patient receiving antihypertensive drugs. Therefore, when therapy with PARCOPA® is started, dosage adjustment of the antihypertensive drug may be required.
For patients receiving MAO inhibitors (Type A or B), see CONTRAINDICATIONS. Concomitant therapy with selegiline and carbidopa and levodopa may be associated with severe orthostatic hypotension not attributable to carbidopa and levodopa alone (see CONTRAINDICATIONS).
There have been rare reports of adverse reactions, including hypertension and dyskinesia, resulting from the concomitant use of tricyclic antidepressants and carbidopa and levodopa.
Dopamine D2 receptor antagonists (e.g., phenothiazines, butyrophenones, risperidone) and isoniazid may reduce the therapeutic effects of levodopa. In addition, the beneficial effects of levodopa in Parkinson's disease have been reported to be reversed by phenytoin and papaverine. Patients taking these drugs with PARCOPA® should be carefully observed for loss of therapeutic response.
Iron salts may reduce the bioavailability of levodopa and carbidopa. The clinical relevance is unclear.
Although metoclopramide may increase the bioavailability of levodopa by increasing gastric emptying, metoclopramide may also adversely affect disease control by its dopamine receptor antagonistic properties.
Carcinogenesis, Mutagenesis, Impairment of Fertility
In a two-year bioassay of carbidopa and levodopa, no evidence of carcinogenicity was found in rats receiving doses of approximately two times the maximum daily human dose of carbidopa and four times the maximum daily human dose of levodopa.
In reproduction studies with carbidopa and levodopa, no effects on fertility were found in rats receiving doses of approximately two times the maximum daily human dose of carbidopa and four times the maximum daily human dose of levodopa.
Pregnancy Category C
No teratogenic effects were observed in a study in mice receiving up to 20 times the maximum recommended human dose of carbidopa and levodopa. There was a decrease in the number of live pups delivered by rats receiving approximately two times the maximum recommended human dose of carbidopa and approximately five times the maximum recommended human dose of levodopa during organogenesis. Carbidopa and levodopa caused both visceral and skeletal malformations in rabbits at all doses and ratios of carbidopa/levodopa tested, which ranged from 10 times/5 times the maximum recommended human dose of carbidopa/levodopa to 20 times/10 times the maximum recommended human dose of carbidopa/levodopa.
There are no adequate or well-controlled studies in pregnant women. It has been reported from individual cases that levodopa crosses the human placental barrier, enters the fetus, and is metabolized. Carbidopa concentrations in fetal tissue appeared to be minimal. Use of PARCOPA® in women of childbearing potential requires that the anticipated benefits of the drug be weighed against possible hazards to mother and child.
Adverse Reactions/Side Effects
The most common adverse reactions reported with carbidopa and levodopa therapy have included dyskinesias, such as choreiform, dystonic, and other involuntary movements and nausea.
The following other adverse reactions have been reported with carbidopa and levodopa:
Body as a Whole: chest pain, asthenia.
Cardiovascular: cardiac irregularities, hypotension, orthostatic effects including orthostatic hypotension, hypertension, syncope, phlebitis, palpitation.
Gastrointestinal: dark saliva, gastrointestinal bleeding, development of duodenal ulcer, anorexia, vomiting, diarrhea, constipation, dyspepsia, dry mouth, taste alterations.
Hematologic: agranulocytosis, hemolytic and nonhemolytic anemia, thrombocytopenia, leukopenia.
Hypersensitivity: angioedema, urticaria, pruritus, Henoch-Schonlein purpura, bullous lesions (including pemphigus-like reactions).
Musculoskeletal: back pain, shoulder pain, muscle cramps.
Nervous System/Psychiatric: psychotic episodes including delusions, hallucinations, and paranoid ideation, neuroleptic malignant syndrome (see WARNINGS), bradykinetic episodes ("on-off" phenomenon), confusion, agitation, dizziness, somnolence, dream abnormalities including nightmares, insomnia, paresthesia, headache, depression with or without development of suicidal tendencies, dementia, pathological gambling, increased libido including hypersexuality, impulse control symptoms. Convulsions also have occurred; however, a causal relationship with carbidopa and levodopa has not been established.
Respiratory: dyspnea, upper respiratory infection.
Skin: rash, increased sweating, alopecia, dark sweat.
Urogenital: urinary tract infection, urinary frequency, dark urine.
Laboratory Tests: decreased hemoglobin and hematocrit; abnormalities in alkaline phosphatase, SGOT (AST), SGPT (ALT), lactic dehydrogenase, bilirubin, blood urea nitrogen (BUN), Coombs test; elevated serum glucose; white blood cells, bacteria, and blood in the urine.
Other adverse reactions that have been reported with levodopa alone and with various carbidopa and levodopa formulations, and may occur with PARCOPA® are:
Body as a Whole: abdominal pain and distress, fatigue.
Cardiovascular: myocardial infarction.
Gastrointestinal: gastrointestinal pain, dysphagia, sialorrhea, flatulence, bruxism, burning sensation of the tongue, heartburn, hiccups.
Metabolic: edema, weight gain, weight loss.
Musculoskeletal: leg pain.
Nervous System/Psychiatric: ataxia, extrapyramidal disorder, falling, anxiety, gait abnormalities, nervousness, decreased mental acuity, memory impairment, disorientation, euphoria, blepharospasm (which may be taken as an early sign of excess dosage; consideration of dosage reduction may be made at this time), trismus, increased tremor, numbness, muscle twitching, activation of latent Horner's syndrome, peripheral neuropathy.
Respiratory: pharyngeal pain, cough.
Skin: malignant melanoma (see also CONTRAINDICATIONS), flushing.
Special Senses: oculogyric crises, diplopia, blurred vision, dilated pupils.
Urogenital: urinary retention, urinary incontinence, priapism.
Miscellaneous: bizarre breathing patterns, faintness, hoarseness, malaise, hot flashes, sense of stimulation.
Laboratory Tests: decreased white blood cell count and serum potassium; increased serum creatinine and uric acid; protein and glucose in urine.
Management of acute overdosage with PARCOPA® is the same as management of acute overdosage with levodopa. Pyridoxine is not effective in reversing the actions of PARCOPA®.
General supportive measures should be employed, along with immediate gastric lavage. Intravenous fluids should be administered judiciously and an adequate airway maintained. Electrocardiographic monitoring should be instituted and the patient carefully observed for the development of arrhythmias; if required, appropriate anti-arrhythmic therapy should be given. The possibility that the patient may have taken other drugs as well as PARCOPA® should be taken into consideration. To date, no experience has been reported with dialysis; hence, its value in overdosage is not known.
Based on studies in which high doses of levodopa and/or carbidopa were administered, a significant proportion of rats and mice given single oral doses of levodopa of approximately 1500-2000 mg/kg are expected to die. A significant proportion of infant rats of both sexes are expected to die at a dose of 800 mg/kg. A significant proportion of rats are expected to die after treatment with similar doses of carbidopa. The addition of carbidopa in a 1:10 ratio with levodopa increases the dose at which a significant proportion of mice are expected to die to 3360 mg/kg.
Parcopa Dosage and Administration
Instructions for Use/Handling PARCOPA® Tablets
Just prior to administration, GENTLY remove the tablet from the bottle with dry hands. IMMEDIATELY place the PARCOPA® Tablet on top of the tongue where it will dissolve in seconds, then swallow with saliva. Administration with liquid is not necessary.
The optimum daily dosage of PARCOPA® must be determined by careful titration in each patient. PARCOPA® is available in a 1:4 ratio of carbidopa to levodopa (PARCOPA® 25/100) as well as 1:10 ratio (PARCOPA® 25/250 and PARCOPA® 10/100). Tablets of the two ratios may be given separately or combined as needed to provide the optimum dosage.
Studies show that peripheral dopa decarboxylase is saturated by carbidopa at approximately 70 to 100 mg a day. Patients receiving less than this amount of carbidopa are more likely to experience nausea and vomiting.
Usual Initial Dosage
Dosage is best initiated with one tablet of PARCOPA® 25/100 three times a day. This dosage schedule provides 75 mg of carbidopa per day. Dosage may be increased by one tablet every day or every other day, as necessary, until a dosage of eight tablets of PARCOPA® 25/100 a day is reached.
If PARCOPA® 10/100 is used, dosage may be initiated with one tablet three or four times a day. However, this will not provide an adequate amount of carbidopa for many patients. Dosage may be increased by one tablet every day or every other day until a total of eight tablets (2 tablets q.i.d.) is reached.
How to Transfer Patients from Levodopa
Levodopa must be discontinued at least twelve hours before starting PARCOPA® (carbidopa and levodopa orally disintegrating tablets). A daily dosage of PARCOPA® should be chosen that will provide approximately 25 percent of the previous levodopa dosage. Patients who are taking less than 1500 mg of levodopa a day should be started on one tablet of PARCOPA® 25/100 three or four times a day. The suggested starting dosage for most patients taking more than 1500 mg of levodopa is one tablet of PARCOPA® 25/250 three or four times a day.
Therapy should be individualized and adjusted according to the desired therapeutic response. At least 70 to 100 mg of carbidopa per day should be provided. When a greater proportion of carbidopa is required, one tablet of PARCOPA® 25/100 may be substituted for each tablet of PARCOPA® 10/100. When more levodopa is required, PARCOPA® 25/250 should be substituted for PARCOPA® 25/100 or PARCOPA® 10/100. If necessary, the dosage of PARCOPA® 25/250 may be increased by one-half or one tablet every day or every other day to a maximum of eight tablets a day. Experience with total daily dosages of carbidopa greater than 200 mg is limited.
Because both therapeutic and adverse responses occur more rapidly with PARCOPA® than with levodopa alone, patients should be monitored closely during the dose adjustment period. Specifically, involuntary movements will occur more rapidly with PARCOPA® than with levodopa. The occurrence of involuntary movements may require dosage reduction. Blepharospasm may be a useful early sign of excess dosage in some patients.
Addition of Other Antiparkinsonian Medications
Standard drugs for Parkinson's disease, other than levodopa without a decarboxylase inhibitor, may be used concomitantly while PARCOPA® is being administered, although dosage adjustments may be required.
Interruption of Therapy
Sporadic cases of a symptom complex resembling Neuroleptic Malignant Syndrome (NMS) have been associated with dose reductions and withdrawal of carbidopa and levodopa. Patients should be observed carefully if abrupt reduction or discontinuation of PARCOPA® is required, especially if the patient is receiving neuroleptics. (See WARNINGS.)
If general anesthesia is required, PARCOPA® may be continued as long as the patient is permitted to take fluids and medication by mouth. If therapy is interrupted temporarily, the patient should be observed for symptoms resembling NMS, and the usual daily dosage may be administered as soon as the patient is able to take oral medication.
How is Parcopa supplied
PARCOPA® (carbidopa and levodopa orally disintegrating tablets) 25/100 are yellow, round, flat-faced, mint-flavored, scored and engraved "25/100" on the unscored side and "SP" above and "342" below the score on the other side. They are supplied as follows:
Bottles of 100 NDC 18860-342-01
PARCOPA® (carbidopa and levodopa orally disintegrating tablets) 10/100 are blue, round, flat-faced, mint-flavored, scored and engraved "10/100" on the unscored side and "SP" above and "341" below the score on the other side. They are supplied as follows:
Bottles of 100 NDC 18860-341-01
PARCOPA® (carbidopa and levodopa orally disintegrating tablets) 25/250 are blue, round, flat-faced, mint-flavored, scored, and engraved "25/250" on the unscored side and "SP" above and "343" below the score on the other side. They are supplied as follows:
Bottles of 100 NDC 18860-343-01
Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Protect from moisture and light.
Dispense in a tight, light-resistant container as defined in the USP/NF.
Distributed by:
Azur Pharma, Inc.
Philadelphia, PA 19103, USA
U.S. Patent Nos. 6,024,981 and 6,221,392.
PARCOPA® is a registered trademark of SRZ Properties, Inc.
Rev. 01/11
Principal Display Panel - 10/100 mg Bottle Label
100 tablets
(carbidopa and levodopa orally disintegrating tablets)
10 mg /100 mg
Rx only
orally disintegrating tablets
Each mint-flavored, orally disintegrating tablet contains 10 mg carbidopa and 100 mg levodopa.
Phenylketonurics: contains phenylalanine 3.4 mg per tablet.
USUAL DOSAGE: See package insert for further information. Do not remove PARCOPA® Tablets from the bottle until immediately before use.
Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Protect from moisture and light.
Dispense in a tight, light-resistant container as defined in the USP/NF.
Distributed by:
Azur Pharma, Inc.
Philadelphia, PA 19103, USA
U.S. Patent Nos. 6,024,981 and 6,221,392
PARCOPA® is a registered trademark of SRZ Properties, Inc.
Rev. 01/11 2E
Principal Display Panel - 25/100 mg Bottle Label
100 tablets
(carbidopa and levodopa orally disintegrating tablets)
25 mg /100 mg
Rx only
orally disintegrating tablets
Each mint-flavored, orally disintegrating tablet contains 25 mg carbidopa and 100 mg levodopa.
Phenylketonurics: contains phenylalanine 3.4 mg per tablet.
USUAL DOSAGE: See package insert for further information. Do not remove PARCOPA® Tablets from the bottle until immediately before use.
Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Protect from moisture and light.
Dispense in a tight, light-resistant container as defined in the USP/NF.
Distributed by:
Azur Pharma, Inc.
Philadelphia, PA 19103, USA
U.S. Patent Nos. 6,024,981 and 6,221,392
PARCOPA® is a registered trademark of SRZ Properties, Inc.
Rev. 01/11 2E
Principal Display Panel - 25/250 mg Bottle Label
100 tablets
(carbidopa and levodopa orally disintegrating tablets)
25 mg / 250 mg
Rx only
orally disintegrating tablets
Each mint-flavored, orally disintegrating tablet contains 25 mg carbidopa and 250 mg levodopa.
Phenylketonurics: contains phenylalanine 8.4 mg per tablet.
USUAL DOSAGE: See package insert for further information. Do not remove PARCOPA® Tablets from the bottle until immediately before use.
Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Protect from moisture and light.
Dispense in a tight, light-resistant container as defined in the USP/NF.
Distributed by:
Azur Pharma, Inc.
Philadelphia, PA 19103, USA
U.S. Patent Nos. 6,024,981 and 6,221,392
PARCOPA® is a registered trademark of SRZ Properties, Inc.
Rev. 01/11 2E
carbidopa and levodopa tablet, orally disintegrating |
carbidopa and levodopa tablet, orally disintegrating |
carbidopa and levodopa tablet, orally disintegrating |
Labeler - Jazz Pharmaceuticals, Inc. (135926363) |
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Sinemet, Rytary, Sinemet CR, Dhivy, Duopa


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Mortgages that are insured by the Federal Housing Administration. The FHA's 203(b) loan program provides low-rate mortgages to buyers who make a down payment as small as 3 percent. The agency also operates loan plans for investors and purchasers of rural property.
The part of a building facing the street or a courtyard.
A federal law that governs credit and charge card billing errors. If a credit or charge card company violates any provision, consumers can sue to recover damages.
A federal law passed in 1971 that regulates the activity of credit bureaus. It is designed to prevent inaccurate or obsolete information from staying in a consumer's credit file and requires credit bureaus to have reasonable procedures for gathering, maintaining and disseminating credit information. The act also requires credit bureaus to show a consumer their credit file if the consumer presents proper identification, although the bureau reserves the right to charge a fee for doing so.
A federal law passed in 1977 which outlaws debtor harassment and other types of collection practices. The act regulates collection agencies, original creditors who set up a separate office to collect debts, and lawyers hired by the creditor to help collect overdue bills. An original creditor–the company or individual that originally granted the credit–is not covered by the act, but may be covered by similar measures approved by state governments.
Landmark federal law passed in 1965 and amended in 1988 that makes it illegal to deny rent or refuse to sell to anyone based on race, color, religion, sex or national origin. The 1988 amendment expanded the protections to include family status and disability.
The official name of the Federal National Mortgage Association, it is a congressionally chartered, shareholder-owned company that buys mortgages from lenders and resells them as securities on the secondary mortgage market.
A U.S. Department of Agriculture agency that provides credit to farmers and rural residents.
A board that connects the ends of the roof rafters and provides a surface to support gutters.
The Federal Home Loan Mortgage Corporation, commonly known as Freddie Mac. The company buys mortgages from lending institutions, pools them with other loans and then sells shares to investors.
This government agency operates a variety of home-loan programs. Its most popular is the Sec. 203(b), program, which provides low-rate mortgages to buyers who make a down payment as small as 3 percent.
Now officially dubbed Fannie Mae, this federally chartered agency buys mortgages from lending institutions, pools them with other loans and sells shares to investors.
A group of economists and other experts who set the nation's monetary policy. Its chief tool to control inflation is the power to control interest rates.
The government agency responsible for regulating a variety of companies and industries, from credit bureaus and collection agencies to timeshare operators and certain types of creditors. National headquarters: Sixth and Pennsylvania Avenue NW, Washington, D.C. 20580. Phone: (202) 326-2222.
The all-American home architecture style that evolved after the Revolutionary War. Details include bigger windows and a front doorway surrounded by glass and topped with an arched window.
This type of ownership is the maximum interest a person can have in a piece of real estate. It entitles the owner to use the property in any manner they see fit, in accordance with state and local laws.
The owner of the property holds a fee simple title contingent upon certain conditions.
An ancient Chinese belief that the physical characteristics of a house and the positioning of the home will affect the fortunes of the owner.
The relationship of trust that buyers and sellers expect from a real estate agent. The term also applies to legal and business relationships.
Modifications made on the construction site that do not match blueprints.
Soil brought in to solidify a finished foundation.
An area where the ground has been raised by adding dirt, gravel or other fill material.
A fee in any amount that is paid to someone.
A finish that prepares a lot for landscaping.
A buffer composed of fire-resistant material.
A promise made by a lender when it agrees to loan money for the purchase of property.
The primary mortgage on a property that has priority over all other voluntary liens.
The monthly payment on a home loan.
The specific weeks in a year an owner of a timeshare arrangement has access to accommodations.
A home loan with an interest rate that will remain at a specific rate for the term of the loan. About 75 percent of all home mortgages have fixed rates.
A house that needs refurbishment or remodeling It usually sells at a below-market price.
Personal property permanently attached to a house, such as drapery rods, toilets, built-in bookcases or a furnace.
Metal strips placed around chimneys, skylights, vents, windows, doors, beneath shingles and along seams in the roof to prevent water seepage.
A set fee charged by a broker instead of a commission.
A roof with a level surface.
A drain that diverts water from the basement to a collection area. Water is then removed with a sump pump.
Walls built to withstand movement in the basement floor.
Hazard coverage that is required in designated flood areas.
Flat, flood-prone areas located along waterways.
The calculation of the floor area of all homes or buildings in a project. It is used in the planning and development of a site.
Enclosed porches built on the side or back of a home.
Concrete foundations that support a structure.
The owner acts as the agent to avoid paying a sales commission.
A course of action a lender may pursue to delay foreclosure or legal action against a delinquent borrower.
The legal process reserved by a lender to terminate the borrower's interest in a property after a loan has been defaulted. When the process is completed, the lender may sell the property and keep the proceeds to satisfy its mortgage and any legal costs. Any excess proceeds may be used to satisfy other liens or be returned to the borrower.
The relinquishing of property rights by a delinquent borrower.
The support structure of a house.
The entrance hall to a home or building.
The construction of the skeletal framework of a house.
The common name for the Federal Home Loan Mortgage Corporation, a congressionally chartered institution that buys mortgages from lenders and resells them as securities on the secondary mortgage market.
Owners of these types of lots may hire any builder to construct their home.
Two adjoining doors inlaid with glass that open from the middle.
The portion of property that borders a roadway or body of water.
A mortgage that amortizes, or pays down, the balance of a loan.
An enclosed heating device powered by coal, oil, propane or natural gas.
A device that allows power to be channeled into a home.

subset: commoncrawl


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Published on : Thursday, May 8, 2014
klia2 has now operated for 4 full days successfully with Malindo Airways, Lion Air, Tiger Airways International and Cebu Pacific Airways.
In the last 24 hours from 12.01am on 5 May until 12.01am on 6 May, a total of 46 flights movement and 6,140 passengers were recorded for both international and domestic, arrivals and departures. There were 30 total flights from Malindo Airways, 6 from Lion Air, 6 from Tiger Airways and 4 from Cebu Pacific Airways.
While the core operational systems at klia2 such as the check-in system, baggage handling system and the passenger boarding bridge (aerobridge) continues to operate efficiently, Malaysia Airports observed one or two isolated incidents whereby the airlines were having some resource issue on ground handling activities, particularly in the unloading of baggage from the aircraft. This had resulted in longer waiting time for the passengers to reclaim the baggages. Malaysia Airports is working closely with the airlines to assist them in improving on the response time.
The 4- day trend has shown that there are ample supply of public transportation systems at the Transportation hub including Taxi, Bus and Express Rail Link (ERL) with a total of 396 taxi trips and 254 bus passengers handled. The ERL services have also been running smoothly for passengers and staff alike, connecting the KL City Sentral, KLIA and klia2.
Passengers or public can approach Malaysia Airports' Information Counters that are strategically located at klia2 for any queries or assistance. Malaysia Airports has also placed ambassadors and customer service assistants at klia2 since 2 May to assist passengers during this transition period.
The passengers are reminded to contact their respective airlines in advance to confirm details of their flights, especially the departure and arrival terminal to avoid any inconveniences, and to continue observing proper time management to ensure they arrive at the terminal in timely manner for their flights. Check-in counters are open 3 hours prior to flight time and closed 1 hour before flight time.
AirAsia, AirAsia X, Indonesia AirAsia, Thai AirAsia and AirAsia Zest will start to operate at klia2 starting on Friday, 9 May when all their flights will arrive and depart from klia2.
Source:- Malaysia Airports
Tags: Malaysia Airports


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Feiyide Automatic Vertical Lift Rack Chrome Electroplating / Plating Equipment for Water Faucet
Product Description
This rack plating equipment is for screw, hinges, buttom plating.
The dimension can be flexibly modified according to your specific requirements.
Features of our plating machine:
1.High quality and reasonable price
2.PP plating barrels
4.Customer designed
5.Strong structure.
6.Easy to operate
1.Model No. | FYD-Al |
2.Raw Material | Polypropylene(PP),Stainless Steel, PVC, Copper, |
3.Features | 1.Anti-corrosion. 2.Protection and decoration. 3.Wear-resisting property. 4.Supply conductive and insulating coatings. 5.Process requirements |
4.Size | Customized, we make the machines based on the clients' project needs |
5.Application | Different kind of plating for metal and plastic products. |
6.Advantage | Flexible design, safe, stable and high strength |
7.Surrounding equipments | Rectifiers, Filters, Air blower, waste gas treatment system and so on |
8.Model | Automatic, Semi – automatic, Manual |
9.Warranty | 18 months (Considering the time for assemble and test. We extend the time from 12 month to 18 month. |
10.Packaging | Eco-friendly Wooden Crates |
11.Shipping | By sea or by air |
12.After-sale Service | 1 Year, if it's necessary our engineers will come directly |
13.Engineering Service | CAD or Sideworks(Computer - Aided Design) drawing, control panel layouts, full size plotting, fabrication drawing , equipment layout and design, piping schematics, complete factory design and layout, seismic calculations, permitting services |
14.Attention | We are customized machines and we often provide you with the EXW price. |
Company Information
Dongguan Feiyide Machinery Equipment Factory is a professional manufacturing enterprise of electroplating machine which collects together R&D, production and sale. Our company
aims to further research and development of plating equipment and provide customers with the most excellent and suitable service.
Why Choose Us
1. Advanced technology
We have a good cooperation with first class chemical liquid supplier, so we can provide environment-al, economic design and suitable process design for production.
2. Optimized electroplating products' design
We have optimized design system for plating tank, plating barrel and plating line, framework and control system. Over 15 years design and construction experience.
3. Using high-quality material and equipments
4. Provide process training
We offer training course of technical certification for customers and the directors are with over 10 yea-rs' experience.
5. Service assurance
We provide 7*24 hours multilingual services(Chinese, English, French, Russian, Arabic,
Global Location
Large storage warehouse
DMS equipments: online failure analysis and maintenance system.
Packaging & Shipping
Packing: According to the different products and quantity are packed in a wooden container, such as 20GP/40GP/40HQ.
Shipping: By sea or according to the special request of the buyer.
1.Q: We need plating machine for ×××, could you send me a quotation?
A: Because plating machine is always customized for different products, we'd like to send you
quotation and make the design for you based on knowing detailed information from you first.
2.Q: What is the necessary information you need for design?
A: The plating prosess you have had, The capacity of your per products, The material, weight,
size, and surface area of your per product, The thickness of plating layer, Your working hours
per day, Type of salt spray test and time, Workshop dimension and so on.
3.Q: What's the lead time for one project?
A: It usually would take about 15-30days days for production and the time is based on specific projects
4.Q: How can I carry out my work if I plan to set up a new plating line?
A:It would be better if we could communicate with your chemical liquid supplier on the process details first. Besides, professional engineer is also important for your project.
Contact Us
We guarantee 18months warranty after the equipment was passed test. Seller react during 48 hours after receive report. The warranty will be recounted if change the contract's equipment or the accessory is for repair. If the equipment stand or change after debug, the buyer can require return the equipment and seller have to move the equipment within 7 days.
We can provide you the following service:
1. Project design
2. Manufacturing
3. Installation and test
4. After-sale service


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Collections: Most Popular, New Items, Ready-to-Wear Jewelry
At Solid Oak, we aim to create products that go beyond just looking good - our goal is to make the process of creating handmade jewelry and decor magical. That's why most of our products are DIY.
We feature over 500 hand-picked jewelry and décor products perfect for a variety DIY projects. Browse all of our featured items, categorized by style and collection.
Shop All


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I'm back with my last birthday giveaway! Next week I'll return to regularly scheduled programming. I have a bunch of videos I've filmed recently that I'm excited to get up. Today i'll feature a product that I discussed in my previous skincare update, here. The Sirirus Skinsonic is an alternative to the Clarisonic for a really great price. It's really changed my skin and I'm super excited to give one of you the chance to try it out.
Click here for more!
Here's how I incorporate the Sirius Skinsonic in my skincare routine:
- Apply my face wash directly to the brush
- Turn on the brush (on and off switch, and battery operated) and move the brush in circular motions focusing on ten seconds per area of my face (chin, cheeks, nose, forehead)
- Wash off the facewash and return the brush to its holder to try
- I use this once a day because I think twice might be over-exfoliation
This is a nice dupe of the Clarisonic but it's way more affordable at the price of $49. I've tried cheaper versions before that didn't add up. I like that this is more of a vibrating tool rather than a fully rotating/spinning brush head which is too harsh on the skin. The actual brush head/bristles are also very nicer than some of the cheaper options.
It also comes with several other attachments - normal brush head, sensitive brush head, exfoliation brush head, hydration head and toning head. Honestly, I just stick with the sensitive brush head but I want to try the normal one for exfoliation. I do wish it came with a charger because right now it's battery operated, but i'm sure that would make it more expensive.
You can find these products at www.siriusbeauty.com retailing at only $49.
- Follow my blog
- Leave a comment telling me why you'd like to win
- Open internationally
- I'll pick a winner at random and announce it next week


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Thursday, November 10, 2011
Oven Roasted Cauliflower
From the kitchen of One Perfect Bite...I've been testing some new vegetable recipes for the Thanksgiving holiday. Most of them involve roasting vegetables that are topped with a separately prepared sauce just prior to serving. While they have all been delicious, I think they add an unnecessary layer of complication to an already busy meal. So, I kept refining my search and found a recipe for roasted cauliflower that had been developed by Emeril LaGasse. After an initial testing, I made a few modifications to his recipe and came up with the one I'm sharing with you today. Cauliflower prepared in this fashion is really delicious. I do, however, think the flavors are too strong to serve with turkey and the other elements of a traditional Thanksgiving meal. Having said that, I have no hesitation about serving it with pork, beef or lamb. I love the simplicity of this dish and the ease with which it can prepared. I will make it often. I hope you, too, will give it a try. Here's the recipe.
Oven Roasted Cauliflower...from the kitchen of One Perfect Bite inspired by Emeril LaGasse
1 medium head cauliflower (about 2-1/4 pounds), trimmed and cut into florets
3 large cloves garlic, thinly sliced
1/4 cup olive oil
2 tablespoons lemon juice
1/2 teaspoon salt
1/4 teaspoon black pepper
2 tablespoons grated Parmesan cheese
Heat oven to 450 degrees F. Combine cauliflower and garlic in a large bowl. Drizzle with olive oil, lemon juice, salt and pepper. Transfer, in a single layer, to a large rimmed baking sheet. Roast at 450 degrees F for about 25 minutes, stirring once. Sprinkle with cheese. Serve immediately Yield: 6 servings.
One Year Ago Today: The Colors of India
Two Years Ago Today: Polpettone - Tuscan Meatloaf
77 comments :
- Lifewithspices said...
Awesome i love baked cauliflowers they taste so good.. love this version..
- November 10, 2011 at 12:41 AM
- Ginny Hartzler said...
This looks really good! When I oven roast broccoli, half the time it turns out good, the other half it chars and is not edible!
- November 10, 2011 at 1:18 AM
- Elin said...
Mary...this is good :) I prefer oven baked ones with garlic and parmesan cheese. Thanks for sharing such a simple yet tasty preparation :)
Have a nice day,
Elin - November 10, 2011 at 1:48 AM
- Glamour drops said...
yum, yum, yum. Making my mouth water! I do a similar version, but with a few torn up pieces of sourdough bread sprinkled on the top, just before the olive oil goes on. So it goes crispy.
- November 10, 2011 at 1:55 AM
- Valerie Harrison (bellini) said...
It makes a perfect side dish Mary!!
- November 10, 2011 at 2:11 AM
- Purabi naha said...
Yummy, oven-roasted cauliflower! Loved this.
- November 10, 2011 at 2:21 AM
- Poornima Nair said...
That looks great, love the addition of cheese!
- November 10, 2011 at 2:35 AM
- Priya Suresh said...
Yum yum, wonderful looking delicious cauliflower..
- November 10, 2011 at 4:49 AM
- Lynn said...
I love cauliflower and usually steam it, I'll give roasting a try next time:@)
- November 10, 2011 at 5:02 AM
- Unknown said...
I think roasting cauliflower takes it to a whole new level! Yours looks wonderful - love the garlic and parmesan!
- November 10, 2011 at 5:08 AM
- Tracy's Living Cookbook said...
One of my very favorite things to eat - oven roasted cauliflower. We love it. Nice recipe today! Thanks for sharing it.
- November 10, 2011 at 5:34 AM
- That Girl said...
I seriously made a very similar version of this for dinner this week. It's the first time either my husband or I have liked cauliflower. I added a white sauce to the cauliflower instead of the lemon/garlic/olive oil.
- November 10, 2011 at 5:42 AM
- Clint said...
I'm very glad to see that you have iven recognition to a wonderful veggie that is so often overlooked. I like cauliflower, and usually eat it raw. But this dish looks like it can stand on it's own as a main dish---maybe with a little cornbread. Excellent.
- November 10, 2011 at 7:23 AM
- Jenni said...
I love roasted vegetables and cauliflower is no exception! I actually roast my broccoli very similarly to this, so I will have to try this with cauliflower, too!
- November 10, 2011 at 7:33 AM
- Kim said...
Roasted cauliflower is one of the sidedish I discovred a couple years ago. It changes the taste of this veggie and it is so good. I love the way you do it, with parmesan cheese!
- November 10, 2011 at 7:34 AM
- Tanna said...
Mary, I started making a very similar version of this over the summer and we LOVE it!! I'll have to try it with the parmesan! Thank you so much. Have a wonderful day. blessings ~ tanna
- November 10, 2011 at 7:45 AM
- Catherine said...
Dear Mary, That cauliflower looks so delicious. I would just love to pick one and try it. Blessings, Catherine xo
- November 10, 2011 at 7:47 AM
- Unknown said...
Mary, only you could make want to dig into a dish of cauliflower!! It looks amazing!
- November 10, 2011 at 7:51 AM
- Tasty Trix said...
Cauliflower is SO underrated - I love how it gets to shine here without a fattening creamy sauce (not that there's anything wrong with that, lol!)
- November 10, 2011 at 8:01 AM
- From the Kitchen said...
We like cauliflower and don't have it often enough. This sounds like a tasty and easily prepared side dish. I'm casting around for a different menu this Thansgiving--as I've often done in the past, only to return to the tried and true.
Bonnie - November 10, 2011 at 8:17 AM
- Cindy said...
Mary.....this is just how i make my vegies all the time, i do all my summer vegies this way now! I also roast squash and sweet potatoes all time and usually sprinkle brown sugar on them instead of the cheese :D....thanks for sharing
- November 10, 2011 at 9:06 AM
Lovely flavors and a perfect use for cauliflower :)
Mary x - November 10, 2011 at 9:36 AM
- Lauren @ hey, who cut the cheese? said...
Funny, I was going to roast some cauliflower tonight, but up until now didn't really have much of a game plan. Thanks for this! It sounds really tasty.
- November 10, 2011 at 9:55 AM
- Helene Dsouza said...
Your cauliflower looks very comforting... the garlic, the parmesan,...mhmmm *appetite*
- November 10, 2011 at 10:43 AM
- Sofia.Lopez said...
Hello Mary,
First of all i want to thank you for your kindness and visit to my blog...i´m really glad and i'm waiting for you next visit with open heart :)
Your roasted cauliflower looks amazing, i'm a vegetables lover and in the oven they smell and taste so so god...
Have a great day Mary!
A kiss for you
Sofia :) - November 10, 2011 at 12:00 PM
I could serve this with lamb for Christmas. :)
- November 10, 2011 at 12:01 PM
- Anu Menon said...
we have this one a week atleast minus the cheese and lemon juice. I should try this version out too!
- November 10, 2011 at 12:56 PM
- StephenC said...
I defer to your judgment, but don't exactly see where the flavors would be overwhelming. The color is certainly beautiful. We roast cauliflower, green beans, broccoli and brussells sprouts as our favorite way of preparing them.
- November 10, 2011 at 1:10 PM
- France@beyondthepeel said...
i love roasted cauliflower. I love how you combined the lemon and garlic. The flavors would be delicious on roasted veg.
- November 10, 2011 at 1:11 PM
- David said...
Mary, I love cauliflower and this recipe will help me convince my wife to eat her veggies! Great idea... Thanks and Take Care, Big Daddy Dave
- November 10, 2011 at 1:16 PM
- Joanne said...
With all the fuss of thanksgiving, the simpler the sides are, the better! Love this!
- November 10, 2011 at 1:48 PM
- Top Cuisine avec Lavi said...
Thank you, Mary, for the comment on my blog - Top Cuisine avec Lavi
- November 10, 2011 at 1:59 PM
- Margaret Murphy Tripp said...
Looks great....but my problem is oven space! I need a second oven for the holiday season! We love cauliflower, though and I'll try this on a "regular" day. Thanks for sharing the recipe!
- November 10, 2011 at 3:30 PM
- Stéphanie said...
This looks so good ! And thank you for your lovely comment !
- November 10, 2011 at 4:46 PM
- nannykim said...
Yum that looks so good. I agree with the person that said oven space is at a premium when you have only one oven and are cooking a large turkey. But I can cook this for other meals! Or...well.....could cook it while the turkey is cooling, I suppose.
- November 10, 2011 at 4:47 PM
- Manju @ Manjus Eating Delights said...
Mmmmmm this looks so yumm! Gonna try this next time I buy cauliflower :) thanks for sharing!
Http://manjuseatingdelights.blogspot.com - November 10, 2011 at 5:12 PM
- JG said...
I roast many veggies, but never have roasted cauliflower. Sounds really good!
~Judy - November 10, 2011 at 6:28 PM
- Red Nomad OZ said...
I've never tried cauliflower in this way before - but we'll soon fix that!! Have a great weekend!!
- November 10, 2011 at 6:36 PM
- Torviewtoronto said...
delicious looking roasted cauliflower wonderfully done
- November 10, 2011 at 7:52 PM
- Karen (Back Road Journal) said...
Hi Mary, I love to roast cauliflower. It adds a kind of nuttiness to the flavor. And I then like to add it to a pasta dish that I make.
- November 10, 2011 at 8:29 PM
- Claudia said...
Mary! I am doing the same thing! Testing vegetables for Thanksgiving - because I am not allowed to deviate from the way we do the turkey, the stuffing, the pumpkin pie... really - doesn't anyone want change? So am playing with cauliflower - which I thought I didn't like until I discovered better recipes - like this - this is a better recipe! End of thesis. Have a grand one.
- November 10, 2011 at 9:51 PM
- Rambling Tart said...
How I adore roasted vegetables, Mary! :-) I made a similar dish a couple years ago and seeing yours today reminded me how much I liked it! :-) I must make it again soon. :-)
- November 10, 2011 at 11:53 PM
- Chiara said...
I love cauliflowers, I'll try soon your recipe Mary!Thanks for sharing, have a good weekend...
- November 11, 2011 at 12:45 AM
- Stephanie said...
This looks great. Cauliflower is one of those vegetables I seem to forget about. But this would be perfect for Thanksgiving.
- November 11, 2011 at 6:43 AM
- Tender B. said...
Looks like a meal fit for a vegetarian king. I'll give it a try, if you insist...
- November 11, 2011 at 10:50 AM
- Guvi said...
As I said before, I'm on the lookout for vegetarian dishes for the Thanksgiving office lunch, so here is another one I bookmarked. Thank you so very much, Mary, I hope you'll have a wonderful weekend!
- November 11, 2011 at 5:25 PM
- The Single Nester said...
I love cauliflower and am always looking for ways to use it.
- November 11, 2011 at 5:30 PM
- Gisela said...
I love roasted cauliflower too! I love just putting cauliflower florets on a tray covered with tinfoil (for easy clean up) and just letting them brown (I like them really well done). I don't even use any oil. They taste great with just some salt and pepper (sometimes I'll also season with red pepper flakes or some cinnamon).
- November 11, 2011 at 9:16 PM
- Becki's Whole Life said...
I like this recipe because it adds some flavor but still let's the cauliflower flavor (which I really like) shine through. I would love to see this on the Thanksgiving table.
- November 12, 2011 at 7:00 AM
- Lori said...
What a lovely recipe. I have to admit I roast all kinds of veggies, but have yet to try cauliflower. Delicious!
- November 12, 2011 at 8:30 AM
- Monet said...
We eat cauliflower every week. I can't wait to add this to our monthly rotation. Simple yet delicious. Thank you for sharing your creativity with me. Your blog is a great way to start my weekend. I hope your weekend is relaxing and that you get to bake some yummy treats!
- November 12, 2011 at 10:14 AM
- Eternal Instants said...
This sounds so good! My kids love raw cauliflower, I would love to try this to see if they would like it cooked as well! Thanks for sharing :)
- November 12, 2011 at 10:38 PM
- DJ said...
I cant wait to try this out, it sounds absolutely delicious!! :)
- September 19, 2012 at 1:48 PM
- Life's a Bowl said...
This sounds great! I love roasted cauliflower + parm cheese but have never combined the two!
- October 3, 2012 at 5:55 PM
I made this recipe tonight minus the lemon juice because i forgot to buy it, and it was AMAZING! It tasted just like garlic bread, but it was cauliflower! Thank you soo much, and I will definitely be making this as a veggie side when I'm trying to impress people with my culinary skills! My husband who always just eats a bite of the veggies to be polite, ate a huge helping. Thank you!
- November 28, 2012 at 11:38 PM
- tspn said...
I tried this last night and it was great! My husband even said he liked it twice, that is huge for him. Will do this often. Thanks!
- January 17, 2013 at 6:49 AM
- Unknown said...
I made this tonight, I loved it! I had some left over brussels sprouts and added them to the cauliflower, they were good too. Love, love roasted veggies and will add this recipe to our family favorites.
- January 29, 2013 at 8:04 PM
- Unknown said...
what a great way to cook cauliflower! I made it tonight and added some leftover brussel sprouts. YUM!! I will never steam a veg again!
- January 29, 2013 at 8:08 PM
- Mary Bergfeld said...
I received an anonymous comment asking what this dish had been garnished with. I used Italian parsley for the photo. Please remember that anonymous comments - good or bad - are not published here.
Blessings...Mary - February 23, 2013 at 7:48 PM
- Unknown said...
Just wanted to give you the heads up that this website has your recipe and photos: http://www.quickneasyrecipes.net/oven-roasted-cauliflower/
- February 28, 2013 at 6:27 PM
- nicolepiper said...
I made this with dinner tonight and it was INCREDIBLE! Everyone loved it and you're totally right, I don't think I could make cauliflower any other way now! Thanks for sharing!
- March 13, 2013 at 6:44 PM
- Unknown said...
As much as I love cauliflower, I don't think I've ever enjoyed it more! Thanks so much for the recipe!
- May 2, 2013 at 6:08 PM
- Kelly said...
It is in the oven as I type. Love cauliflower and am excited to try this dish. Keep the healthy veggie ideas coming.
- August 31, 2013 at 4:26 PM
Thank you for a new way to cook one of my favourites, the humble Cauliflower. My main fare is Cauliflower au Gratin which is a staple for our "family roasts". Your recipe is on the agenda for this weekend, serving with Spiced Orange Roast Chicken and the regular potato mash with lashings of butter.
- September 13, 2013 at 3:27 AM
- Mel @ Trailing After God said...
Trying it tonight! It smells delicious already :)
- September 21, 2013 at 9:04 PM
- Sandy said...
Just made this, oh my word, so good!
- December 29, 2013 at 6:18 PM
- Kathy Kay said...
I made this tonight for my family and they loved it. My teen-age daughter decided it satisfies the craving for carbs, but isn't potatoes. I loved it because it was so easy! Clean up was easy too.
- January 27, 2014 at 8:29 PM
Just made this, so, so good!
- February 26, 2014 at 11:53 PM
- Unknown said...
Simple ingredients, delicious flavor. This recipe's a keeper! Thanks.
- May 29, 2014 at 10:52 PM
- Unknown said...
I add bite size pieces of bacon and it becomes a main dish. Thanks great dish! :)
- July 7, 2014 at 9:15 AM
- dilpreet said...
I like this recipe .its very simple yet delicious.
- August 19, 2014 at 2:04 AM
- Martha said...
This sounds delicious and simple! Will have to try it! I'm in the habit of only eating cauliflower raw with a dip and I think it's time to kick it up a notch! :) Thanks for sharing!
- October 31, 2014 at 8:39 AM
- Jampani Pickles said...
Good One. will try
- October 13, 2016 at 6:21 AM
- Jampani Pickles said...
Very Nice Will Try for Sure. I also Like cauliflower pickle andhra style
- October 13, 2016 at 7:03 AM
If you like raw cauliflower, try a piece before you bake it. I ate half mine raw. The dressing was amazing.
- August 1, 2017 at 4:44 PM
- KarenSTL said...
I just made this for a family dinner, and there wasn't anything left after people went back for seconds. This was the only recipe that was completely gone, so that's a big complement. I love the shaved garlic and the simplicity of the dish. I made it in a glass pan this time, so the veggies didn't get very browned. Next time I'll try it on a metal cookie pan or 9x11 and see if that has an impact on the roasted flavor. But either way, it's a winner.
- September 24, 2017 at 10:55 PM
- Kathy said...
I just mad this tonight for dinner and it was delicious! Thank-you for sharing!
- May 9, 2020 at 8:53 PM


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#7735 - VENOM T-10 PAINTED BODY (RED: M.GRY/200mm/WB255mm)
Completely finished body for Nitro 3 (RTR 3)
New from HPI is a pre-painted version of the Venom T-10 1/10th scale street truck body. The Venom T-10 has aggressive street truck styling, slammed to the ground for high performance, with a flat truck bed and a bolt-on spoiler for extra rear grip. This is a 200mm body that comes pre-painted in bright red with metallic grey, metallic silver and black flames. Highly detailed decals come pre-applied, with bold graphics and realistic lights and grills. This body is ready to go right out of the package, pre-trimmed with all of the holes for the body posts, cooling, antenna, glow starter and exhaust, making installation quick and simple. Available in clear and pre-painted versions: #17500 - VENOM T-10 BODY #7710 - VENOM T-10 BODY PRE PAINTED
The clear HPI Venom bodyshell is made from high quality polycarbonate and offers the same great features as all other HPI bodyshells: 1. Photorealistic pre-cut premium vinyl decals include window frames, headlight, grille, back lights, official logos and more.. > For a perfect finish with a lot of details. 2. Pre-cut vinyl window masks > For easy and precise window masking 3. Wheel centre point marks > For accurate wheel cutting 4. Overspray film > For a immaculate finish without overspray 5. High quality polycarbonate with excellent dimensional stability and impact resistance > For extra strength and longer life 6. Dimple marks for body post drill locations that fits all HPI and Tamiya cars (TL-01 size) > For easy drilling and accurate fitting to the chassis 7. Wings incl. winglets and mounting screws (not for all types) > For optimal down force and cool look 8. Decal and mounting instructions sheet > To make fitting as easy as possible Recommended for use on the HPI Nitro RS4 3 series of cars, but can be used on most 200mm touring cars with minor modifications.


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If you use Chrome, Firefox, Safari or Internet Explorer 8+, open google.com in a new tab, load Chrome's JavaScript console (Ctrl+Shift+J), Firefox's Web Console (Ctrl+Shift+K), Safari's Web Inspector (how to do that?) or IE's Developer Tools (press F12 and select the "console" tab) and paste the following code:
document.cookie="PREF=ID=03fd476a699d6487:U=88e8716486ff1e5d:FF=0:LD=en:CR=2:TM=1322688084:LM=1322688085:S=McEsyvcXKMiVfGds; path=/; domain=.google.com";window.location.reload();
Then press Enter and close the console. If you're not in the US and you're using a different Google domain, replace ".google.com" with your domain in the code (for example: ".google.co.uk" in the UK). Please note that this only works for the English interface, so you many need to adjust the language in the preferences page.
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SACRAMENTO, Calif. (AP) — Across the West, early miners digging for gold, silver and copper had no idea that one day something else very valuable would be buried in the piles of dirt and rocks they tossed aside.
There's a rush in the U.S. to find key components of cellphones, televisions, weapons systems, wind turbines, MRI machines and the regenerative brakes in hybrid cars, and old mine tailings piles just might be the answer. They may contain a group of versatile minerals the periodic table called rare earth elements.
"Uncle Sam could be sitting on a gold mine," said Larry Meinert, director of the mineral resource program for the U.S. Geological Survey in Reston, Va.
The USGS and Department of Energy are on a nationwide scramble for deposits of the elements that make magnets lighter, bring balanced hues to fluorescent lighting and color to the touch screens of smartphones in order to break the Chinese stranglehold on those supplies.
They were surprised to find that the critical elements could be in plain sight in piles of rubble otherwise considered eyesores and toxic waste. One era's junk could turn out to be this era's treasure.
"Those were almost never analyzed for anything other than what they were mining for," Meinert said. "If they turn out to be valuable that is a win-win on several fronts — getting us off our dependence on China and having a resource we didn't know about."
The 15 rare earth elements were discovered long after the gold rush began to wane, but demand for them only took off over the past 10 years as electronics became smaller and more sophisticated. They begin with number 57 Lanthanum and end with 71 Lutetium, a group of metallic chemical elements that are not rare as much as they are just difficult to mine because they occur in tiny amounts and are often stuck to each other.
Unlike metals higher up on the table such as silver and gold, there's no good agent for dissolving elements so closely linked in atomic structure without destroying the target. It makes mining for them tedious and expensive.
"The reason they haven't been explored for in the U.S. was because as long as China was prepared to export enough rare earths to fill the demand, everything was fine — like with the oil cartels. When China began to use them as a political tool, people began to see the vulnerability to the U.S. economy to having one source of rare earth elements," said Ian Ridley, director of the USGS Central Mineral and Environmental Resources Science Center in Colorado.
Two years ago, China raised prices — in the case of Neodymium, used to make Prius electric motors stronger and lighter, from $15 a kilogram in 2009 to $500 in 2011, while Dysprosium oxide used in lasers and halide lamps went from $114 a kilogram in 2010 to $2,830 in 2011. It's also about the time China cut off supplies to Japan, maker of the Prius, in a dispute over international fishing territory.
That's when the U.S. government went into emergency mode and sent geologists to hunt for new domestic sources.
"What we have is a clash of supply and demand. It's a global problem. A growing middle class around the world means more and more people want things like cellphones," said Alex King, director of the Critical Materials Institute of the Department of Energy's Ames Research Lab in Iowa. "Our job is to solve the problem any way we can."
At the University of Nevada-Reno and the Colorado School of Mines, USGS scientists used lasers to examine extensive samples of rocks and ore collected across the West during the gold rush days by geologists from Stanford University and Cal Tech.
"If we could recycle some of this waste and get something out of it that was waste years ago that isn't waste today, that certainly is a goal," said Alan Koenig, the USGS scientist in charge of the tailings project.
One sample collected in 1870 from an area near Sparks, Nev., where miners had searched for a viable copper vein, has shown promise and has given researchers clues in the search for more. They have found that some rare earths exist with minerals they had not previously known occur together.
"The copper mine never went into production, but now after all of this time we've analyzed it and it came back high with Indium, which is used in photovoltaic panels. It never economically produced copper, but it gives us insight into some associations we didn't previously recognize," Koenig said.
Indium also has been found in the defunct copper mine that dominates the artsy southern Arizona town of Bisbee.
Koenig and his colleagues are working to understand the composition of all of the nation's major deposits sampled over the past 150 years. In some cases, the mines were depleted of gold or copper, but the rocks left piled alongside mines and pits could hold a modern mother lode.
"We're revisiting history," he said.
They are compiling data from 2,500 samples to better understand whether it's possible to predict where rare earths might be hiding based on the presence of other elements there, too.
"If I had to venture a number, I'd say we have found several dozen new locations that are elevated in one or more critical metals," Koenig said. "With this project the goal would be to have this large data base available that would allow us to predict and to form new associations."
Currently there is only one U.S. mine producing rare earths— at Mountain Pass in the Southern California desert. Molycorp Inc.'s goal in reopening the defunct mine is 20,000 metric tons of rare earth elements by this summer, including cerium oxide used to polish telescope lenses and other glass.
The USGS is counting on companies like Molycorp to use the information they've gleaned to uncover other easy-to-reach deposits sitting on federal land and elsewhere.
"Without rare earths we'd be back to having black-and-white cellphones again," said the USGS's Ridley.


text:
How do I power reset my LCD / LED or Projection TV?
IMPORTANT: If you have an Android TV™ model, use the How do I power reset my Android TV article instead.
Follow these steps to perform a power reset.
- Turn off the TV.
IMPORTANT: For a projection TV that uses an internal lamp, wait 5 minutes after turning off the TV to allow the lamp to cool before continuing.
- Unplug the TV power cord from the electrical outlet.
- Let the television remain without power for 60 seconds.
- Plug the power cord back into the electrical outlet.
Note: If your TV was previously plugged into a power strip or surge protector, plug it directly into the wall outlet instead in case the power strip or surge protector was causing a problem.
- Turn on the TV.
Note: If the issue is not resolved, then check the BRAVIA TV Troubleshooting Guide article for additional troubleshooting options.


text:
Turning now to Russia. In Moscow, tens of thousands of people took to the streets today in dueling demonstrations for and against the government of Prime Minister Vladimir Putin. Putin is seeking to return to the presidency in next month's elections.
NPR's Corey Flintoff reports from the Russian capital.
COREY FLINTOFF, BYLINE: The anti-Putin demonstrators walked briskly over the ice and slush, facing into a stiff breeze that billowed the banners calling for fair elections. The marchers ranged from hip young urbanites to elderly Communists. Most were well and even fashionably dressed against the cold, a mainly middle-class crowd that was out to make a political statement rather than an economic one.
Pharmacist Mikhail Melikhov says he has attended all three of the major opposition rallies in Moscow.
MIKHAIL MELIKHOV: It's the voice of my soul, because I against this power, because I think this level of corruption is incredible.
FLINTOFF: Still, Melikhov, who's 32, says he's not sure who will get his vote next month. He only knows that it won't be Putin. Across town, the protesters' message was countered by a pro-Putin rally. Organizers said that rally was against the so-called Orange revolutions, like the people-powered demonstrations that reversed an allegedly rigged election in Ukraine. Speakers said that kind of revolution in Russia could lead to mob rule and even civil war. Both sides are claiming huge turnouts, and the opposition points to protest rallies across the county.
An independent count commissioned by the radio station Echo Moscow found that the anti-Putin rally drew almost 66,000 people. That count, based on aerial photographs, said the pro-Putin demonstration was bigger, mustering about 80,000. But at the edge of that rally, there were lines of yellow buses that had carried many people to the event from other parts of Russia. Some people said they'd been pressured by their employers to attend.
The numbers are important because each side wants to show that it has strong public support leading up to the election. They're appealing to Russian anxieties, discontent and patriotism. The anti-Putin rally ended with this song by popular singer Yuri Shevchuk.
FLINTOFF: The lyrics go: The motherland, even though she's deformed, we love her, a sleeping beauty. The opposition says it hopes to hold one more big rally shortly before the elections on March 4th, and the pro-Putin forces may do the same. Corey Flintoff, NPR News, Moscow. Transcript provided by NPR, Copyright NPR.


text:
Obama: 'Suspicious' GOP opposes immigration overhaul for political reasons
President Barack Obama charged Tuesday that some Republicans oppose comprehensive legislation to overhaul the nation's immigration policies because they are "suspicious" that the measure will swell the ranks of Democrats.
"I think some in the House who believe that immigration will encourage further demographic changes -- and that may not be good for them politically," he told Norma Garcia, of Telemundo's KXTX in Fort Worth, Texas.
Obama also rejected calls for a piecemeal approach to the problem – as advocated by some key GOP lawmakers – and said he hoped that the bill could reach his desk in the fall. The president had previously said he hoped it would be done before lawmakers head home next month -- and face voters potentially angry about the sweeping blueprint.
The president's comments came as he sat down for four question-and-answer sessions with Spanish-language TV interviewers, part of a White House push behind the measure, which has stalled in the Republican-held House of Representatives.
"I don't think that we're gonna see it before the August recess," Obama told Garcia. Republican struggles with the bill mean "we may have to go through several more weeks of work before we actually pass the bill. So it probably will -- hopefully happen in the fall."
And he told Maria Rozman of Telemundo's KDEN station in Denver that "Republican House members are wrestling with it."
"Many of their constituents are suspicious of this, suspicious of what immigration might mean for their political futures in some cases," he told Rozman.
(Obama's comments may have been directed at complaints from some Republicans, like Rep. Steve King of Iowa, who have described immigration reform as a way to give citizenship to "undocumented Democrats." But at least he wasn't concern-trolling Republicans, as some supporters of the overhaul have done.)
Obama rejected Republican calls for doing immigration reform piecemeal – notably by pressing ahead with tougher border security first, and only then taking up a potential "path to citizenship" for the estimated 11 million undocumented immigrants on U.S. soil today.
"The danger of doing it in pieces is that a lot of groups want different things. And you know, there's a tendency I think to put off the hard stuff until the end," he told Garcia. "And if you've eaten your dessert before you've eaten your meal, at least with my children, sometimes they don't end up eating their vegetables."
"So we need to, I think, do this as a complete package.," he said.
Obama also rejected the notion that legalizing the status of undocumented immigrants must wait until U.S. borders are perfectly secure.
"We can't make it perfect. You're never going to have zero people crossing the border without the proper papers," he told Rozman. "But we can't use that as an excuse not to solve the problem."
"If we know that what we're doing right now is not working as well as it should, then let's fix 80% of it, 90% of it," he said. "The fact that it might not fix 100% of it is not a reason not to significantly improve the system that we have right now."
Obama also sat down with two Univision stations, KMEX of Los Angeles and WXTV of New York/New Jersey.


text:
Rip Curl Aggrolite Long Sleeve Front Zip Jacket - Black
Rip Curl Aggrolite Long Sleeve Front Zip Jacket - Black
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