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Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
Michael H. Askenase, Brittany A. Goods, Hannah E. Beatty, Arthur F. Steinschneider, Sofia E. Velazquez, Artem Osherov, Margaret J. Landreneau, Shaina L. Carroll, Tho B. Tran, Victor S. Avram, Riley S. Drake, G. James Gatter, Jordan A. Massey, Saravanan S. Karuppagounder, Rajiv R. Ratan, Charles C. Matouk, Kevin N. Sheth, Wendy C. Ziai, Adrian R. Parry-Jones, Issam A. Awad, Mario Zuccarello, Richard E. Thompson, Jesse Dawson, Daniel F. Hanley, J. Christopher Love, Alex K. Shalek, Lauren H. Sansing
Opportunities to interrogate the immune responses in the injured tissue of living patients suffering from acute sterile injuries such as stroke and heart attack are limited. We leveraged a clinical trial of minimally invasive neurosurgery for patients with intracerebral hemorrhage (ICH), a severely disabling subtype of stroke, to investigate the dynamics of inflammation at the site of brain injury over time. Longitudinal transcriptional profiling of CD14+ monocytes/macrophages and neutrophils from hematomas of patients with ICH revealed that the myeloid response to ICH within the hematoma is distinct from that in the blood and occurs in stages conserved across the patient cohort. Initially, hematoma myeloid cells expressed a robust anabolic proinflammatory profile characterized by activation of hypoxia-inducible factors (HIFs) and expression of genes encoding immune factors and glycolysis. Subsequently, inflammatory gene expression decreased over time, whereas anti-inflammatory circuits were maintained and phagocytic and antioxidative pathways up-regulated. During this transition to immune resolution, glycolysis gene expression and levels of the potent proresolution lipid mediator prostaglandin E2 remained elevated in the hematoma, and unexpectedly, these elevations correlated with positive patient outcomes. Ex vivo activation of human macrophages by ICH-associated stimuli highlighted an important role for HIFs in production of both inflammatory and anti-inflammatory factors, including PGE2, which, in turn, augmented VEGF production. Our findings define the time course of myeloid activation in the human brain after ICH, revealing a conserved progression of immune responses from proinflammatory to proresolution states in humans after brain injury and identifying transcriptional programs associated with neurological recovery.
Science Immunology, 2021; 6 (56): eabd6279
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Genomic and evolutionary classification of lung cancer in never smokers
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Mapping single-cell data to reference atlases by transfer learning
Stretchable and bioadhesive gelatin methacryloyl-based hydrogels enabled by in situ dopamine polymerization
Novel assessment of leukocyte-rich platelet rich plasma on functional and patient reported outcomes in knee osteoarthritis: a pilot study
Mapping the dynamic transfer functions of eukaryotic gene regulation
Transcriptional control of brain tumor stem cells by a carbohydrate binding protein
3D bioprinted multicellular vascular models
Neuronal spreading and plaque induction of intracellular Aβ and its disruption of Aβ homeostasis
Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro
Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery
Detection and characterization of lung cancer using cell-free DNA fragmentomes
Topography and permeability analyses of vasculature‐on‐a‐chip using scanning probe microscopies
Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting
Sphingosine-1-phosphate interactions in the spleen and heart reflect extent of cardiac repair in mice and failing human hearts
A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope
Why exercise builds muscles: titin mechanosensing controls skeletal muscle growth under load
Engineering aligned human cardiac muscle using developmentally inspired fibronectin micropatterns
Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4 endothelial cells
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Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state
Quantifying frequency content in cross-sectional retinal scans of diabetics vs. controls
Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites
Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice
Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts
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A proteogenomic portrait of lung squamous cell carcinoma
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Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids
Reinforcement learning links spontaneous cortical dopamine impulses to reward
Drug‐eluting endotracheal tubes for preventing bacterial inflammation in subglottic stenosis
Therapeutic anticoagulation with heparin in noncritically ill patients with COVID-19
Therapeutic anticoagulation with heparin in critically ill patients with COVID-19
Opportunities for biomanufacturing in low earth orbit: current status and future directions
Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells
TROPHY-U-01: a phase II open-label study of sacituzumab govitecan in patients with metastatic urothelial carcinoma progressing after platinum-based chemotherapy and checkpoint inhibitors
Modeling sporadic Alzheimer's disease in human brain organoids under serum exposure
Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis
Association of statin use with clinical outcomes in patients with triple-negative breast cancer
Missing selfinduced microvascular rejection of kidney allografts: a population-based study
Microglia provide structural resolution to injured dendrites after severe seizures
Magnetic assembly of a multifunctional guidance conduit for peripheral nerve repair
PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity
Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques
Unstable regulatory T cells, enriched for naïve and Nrp1neg cells, are purged after fate challenge
Human tumor microenvironment chip evaluates the consequences of platelet extravasation and combinatorial antitumor-antiplatelet therapy in ovarian cancer
Genomes for Kids: The scope of pathogenic mutations in pediatric cancer revealed by comprehensive DNA and RNA sequencing
Fibroblast growth factor receptor 3 alterations and response to immune checkpoint inhibition in metastatic urothelial cancer: a real-world experience
Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing
Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype
An epigenetic switch regulates the ontogeny of AXL positive/EGFR-TKI resistant cells by modulating miR-335 expression
Analysis of high‐risk pedigrees identifies 12 candidate variants for Alzheimer's disease
Modulation of amyloid-β aggregation by metal complexes with a dual binding mode and their delivery across the bloodbrain barrier using focused ultrasound
Complex II subunit SDHD is critical for cell growth and metabolism, which can be partially restored with a synthetic ubiquinone analog
Complex I protein NDUFS2 is vital for growth, ROS generation, membrane integrity, apoptosis, and mitochondrial energetics
Association of monogenic and polygenic risk with the prevalence of open-angle glaucoma
Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer
Restoring endogenous repair mechanisms to heal chronic wounds with a multifunctional wound dressing
Structure-guided microbial targeting of antistaphylococcal prodrugs
Autoantibodies stabilize neutrophil extracellular traps in COVID-19
Transcriptional regulation of N6-methyladenosine orchestrates sex-dimorphic metabolic traits
Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation
Hepatocyte nuclear factor 4 alpha 2 messenger RNA reprograms liver-enriched transcription factors and functional proteins in end-stage cirrhotic human hepatocytes
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
A SNAI2-PEAK1-INHBA stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting subpopulations of tumor cells positive for antiapoptotic and stress signaling markers
Biochemical characteristics and clinical result of bone marrowderived fibrin clot for repair of isolated meniscal injury in the avascular zone
GABA-receptive microglia selectively sculpt developing inhibitory circuits
Huntingtin silencing delays onset and slows progression of Huntingtons disease: a biomarker study
Down-regulation of A20 promotes immune escape of lung adenocarcinomas
Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fiber type transition in soleus muscle during space flight
De-scattering with Excitation Patterning enables rapid wide-field imaging through scattering media
Gut microbiome heritability is nearly universal but environmentally contingent
Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock
Dose-response meta-analysis on tooth loss with the risk of cognitive impairment and dementia
Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine
Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors
An acellular biologic scaffold treatment for volumetric muscle loss: results of a 13-patient cohort study
Matrix bound nanovesicle-associated IL-33 activates a pro-remodeling macrophage phenotype via a non-canonical, ST2-independent pathway
Immunogenicity of COVID-19 vaccination in immunocompromised patients: an observational, prospective cohort study interim analysis
When the human brain goes diving: using near-infrared spectroscopy to measure cerebral and systemic cardiovascular responses to deep, breath-hold diving in elite freedivers
Pervasive inflammatory activation in patients with deficiency in very-long-chain acyl-coA dehydrogenase (VLCADD)
Therapeutic ultrasound triggered silk fibroin scaffold degradation
Pharmaceutical design and development of perfluorocarbon nanocolloids for oxygen delivery in regenerative medicine
A single stiffened nucleus alters cell dynamics and coherence in a monolayer
Pelvic floor shape variations during pregnancy and after vaginal delivery
The immune response is a critical regulator of zebrafish retinal pigment epithelium regeneration
Partial recovery of visual function in a blind patient after optogenetic therapy
A brain-computer interface that evokes tactile sensations improves robotic arm control
Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke
B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers
Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity
Retinal imaging demonstrates reduced capillary density in clinically unimpaired APOE ε4 gene carriers
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
Left atrial appendage occlusion during cardiac surgery to prevent stroke
Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation
Lysine demethylase 5A is required for MYC-driven transcription in multiple myeloma
Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation
Selection of metastasis competent subclones in the tumor interior
Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk
Impact of bamlanivimab monoclonal antibody treatment on hospitalization and mortality among non-hospitalized adults with SARS-CoV-2 infection
Tympanostomy tubes or medical management for recurrent acute otitis media
Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate
Antibody response to 2-dose SARS-CoV-2 mRNA vaccine series in solid organ transplant recipients
Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition
Feeling younger as a stress buffer: Subjective age moderates the effect of perceived stress on change in functional health
ALIX and ceramide differentially control polarized small extracellular vesicle release from epithelial cells
The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
Engineering of diseased human skin equivalent using 3D cell printing for representing pathophysiological hallmarks of type 2 diabetes in vitro
Prognostic value of lower bone mineral density in predicting adverse cardiovascular disease in Asian women
Inner hair cell stereocilia are embedded in the tectorial membrane
Cardiovascular risk factor trajectories since childhood and cognitive performance in midlife: The Cardiovascular Risk in Young Finns Study
AIF3 splicing switch triggers neurodegeneration
A molecular single-cell lung atlas of lethal COVID-19
Mimicking associative learning using an ion-trapping non-volatile synaptic organic electrochemical transistor
Minimally invasive electroceutical catheter for endoluminal defect sealing
Intranasal vaccination with influenza HA/GO-PEI nanoparticles provides immune protection against homo- and heterologous strains
Thresholds of polarization vision in octopuses
Studying tumor angiogenesis and cancer invasion in a three‐dimensional vascularized breast cancer micro‐environment
Engineering T cells to express tumoricidal MDA-7/IL-24 enhances cancer immunotherapy
Roughness and dynamics of proliferating cell fronts as a probe of cellcell interactions
Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration
Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction
VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
Perivascular macrophages regulate blood flow following tissue damage
Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers
Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects
Single virus inductively coupled plasma mass spectroscopy analysis: A comprehensive study
Intra‐operative bioprinting of hard, soft, and hard/soft composite tissues for craniomaxillofacial reconstruction
Fabrication of cartilage-inspired hydrogel/entangled polymerelastomer structures possessing poro-elastic properties
Loneliness and social isolation increase cancer incidence in a cohort of Finnish middle-aged men: a longitudinal study
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome
Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
Combination of polycarboxybetaine coating and factor XII inhibitor reduces clot formation while preserving normal tissue coagulation during extracorporeal life support
The biphasic and age-dependent impact of Klotho on hallmarks of aging and skeletal muscle function
A stromal progenitor and ILC2 niche promotes muscle eosinophilia and fibrosis-associated gene expression
Modular complement assemblies for mitigating inflammatory conditions
Assessment of cumulative incidence and severity of primary open-angle glaucoma among participants in the ocular hypertension treatment study after 20 years of follow-up
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing
Activity-regulated synaptic targeting of lncRNA ADEPTR mediates structural plasticity by localizing Sptn1 and AnkB in dendrites
Integrated computer-aided engineering and design for DNA assemblies
An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function
Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms
PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response
Safety and improved efficacy signals following gene therapy in childhood blindness caused by GUCY2D mutations
Treatment patterns and clinical outcomes after the introduction of the Medicare sepsis performance measure (SEP-1)
Outcomes after sentinel lymph node biopsy and radiotherapy in older women with early-stage, estrogen receptorpositive breast cancer
Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia
Stabilization of damaged articular cartilage with hydrogel‐mediated reinforcement and sealing
Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly
A bacterial small RNA regulates the adaptation of Helicobacter pylori to the host environment
Vascular smooth muscle-derived Trpv1 progenitors are a source of cold-induced thermogenic adipocytes
Bisphenols exert detrimental effects on neuronal signaling in mature vertebrate brains
Epidemiology and risk factors for the development of cutaneous toxicities in patients treated with immune checkpoint inhibitors: A United States population-level analysis
Direct continuous electromyographic control of a powered prosthetic ankle for improved postural control after guided physical training: A case study
Integration of multiomics data with graph convolutional networks to identify new cancer genes and their associated molecular mechanisms
Suboptimal response to COVID-19 mRNA vaccines in hematologic malignancies patients
Antibody responses in elderly residential care persons following COVID-19 mRNA vaccination
Intracellular action potential recordings from cardiomyocytes by ultrafast pulsed laser irradiation of fuzzy graphene microelectrodes
The NIH Somatic Cell Genome Editing Program
All-trans retinoic acid induces synaptic plasticity in human cortical neurons
High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohns disease-associated Escherichia coli
Whole‐genome sequencing reveals new Alzheimer's diseaseassociated rare variants in loci related to synaptic function and neuronal development
DeepTCR is a deep learning framework for revealing sequence concepts within T-cell repertoires
PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications
Incremental change versus disruptive transformation: COVID-19 and the cardiovascular community
Avoiding the coming tsunami of common, chronic disease: what the lessons of the COVID-19 pandemic can teach us
Soluble α-synuclein/antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
Specific populations of basal ganglia output neurons target distinct brain stem areas while collateralizing throughout the diencephalon
Examining sleep deficiency and disturbance and their risk for incident dementia and all-cause mortality in older adults across 5 years in the United States
Open-source, 3D-printed peristaltic pumps for small volume point-of-care liquid handling
Material characterisation and stratification of conjunctival epithelial cells on electrospun poly(e-caprolactone) fibres loaded with decellurised tissue matrices
Impact of monoclonal antibody treatment on hospitalization and mortality among non-hospitalized adults with SARS-CoV-2 infection
Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies
Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment
Reciprocal control of obesity and anxietydepressive disorder via a GABA and serotonin neural circuit
Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging
Cardiac effects of repeated weightlessness during extreme duration swimming compared with spaceflight
Massively parallel sequencing of esophageal brushings enables an aneuploidy-based classification of patients with Barretts esophagus
Active carpets drive non-equilibrium diffusion and enhanced molecular fluxes
Structural insights into the function of the catalytically active human Taspase1
Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction,...
Enrichment of skeletal stem cells from human bone marrow using spherical nucleic acids
Healthy aging and the bloodbrain barrier
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis
Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro
Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions
Are recent cohorts getting worse? Trends in U.S. adult physiological status, mental health, and health behaviors across a century of birth cohorts
trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo
Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling
Identification of bacteria-derived HLA-bound peptides in melanoma
Neuronal circuits overcome imbalance in excitation and inhibition by adjusting connection numbers
US hospital capacity managers experiences and concerns regarding preparedness for seasonal influenza and influenza-like illness
Physiologic improvement in respiratory acidosis using extracorporeal Co2 removal with Hemolung Respiratory Assist System in the management of severe respiratory failure from coronavirus disease 2019
Allogeneic adipose‐derived stem cells mitigate acute radiation syndrome by the rescue of damaged bone marrow cells from apoptosis
Chemical pumps and flexible sheets spontaneously form self-regulating oscillators in solution
TLR3-activated monocyte-derived dendritic cells trigger progression from acute viral infection to chronic disease in the lung
Potent and selective knockdown of Tyrosine Kinase 2 by antisense oligonucleotides
In-vivo sub-diffraction adaptive optics imaging of photoreceptors in the human eye with annular pupil illumination and sub-Airy detection
ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells
Link between mild traumatic brain injury, poor sleep, and MRI-visible perivascular spaces in Veterans
Chemotherapy induces senescence-like resilient cells capable of initiating AML recurrence
A primary care agenda for brain health: a scientific statement from the American Heart Association
Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort study
Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7
Cellular plasticity balances the metabolic and proliferation dynamics of a regenerating liver
Brain microvasculature has a common topology with local differences in geometry that match metabolic load
Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack
Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing
Discovery and validation of a urinary exosome mRNA signature for the diagnosis of human kidney transplant rejection
Association between vision impairment and mortality: a systematic review and meta-analysis
Patient-derived xenografts and organoids model therapy response in prostate cancer
In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury
Machine learning identifies candidates for drug repurposing in Alzheimers disease
Circulating tumour DNA from the cerebrospinal fluid allows the characterisation and monitoring of medulloblastoma
Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment
Inhibition of ATGL in adipose tissue ameliorates isoproterenol-induced cardiac remodeling by reducing adipose tissue inflammation
Induction of four‐dimensional spatiotemporal geometric transformations in high cell density tissues via shape‐changing hydrogels
Transdermal electroosmotic flow generated by a porous microneedle array patch
A sparse multiscale nonlinear autoregressive model for seizure prediction
Estimating risk of mechanical ventilation and in-hospital mortality among adult COVID-19 patients admitted to Mass General Brigham: The VICE and DICE scores
Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies
Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization
SARS-CoV-2 causes a different cytokine response compared to other cytokine storm-causing respiratory viruses in severely ill patients
Exacerbation of epilepsy by astrocyte alkalization and gap junction uncoupling
Reversible self-assembly of superstructured networks
Superstructured biomaterials formed by exchange dynamics and hostguest interactions in supramolecular polymers
Association of hypertensive disorders of pregnancy with left ventricular remodeling later in life
Self‐assembling nanofibers inhibit inflammation in a murine model of Crohn's‐disease‐like ileitis
Structural basis for differential recognition of phosphohistidine-containing peptides by 1-pHis and 3-pHis monoclonal antibodies
A unifying framework for mean-field theories of asymmetric kinetic Ising systems
Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification
The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters
Functional skeletal muscle regeneration with thermally drawn porous fibers and reprogrammed muscle progenitors for volumetric muscle injury
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
Mechanism of membrane-tethered mitochondrial protein synthesis
Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders
Massive expansion of human gut bacteriophage diversity
Macrophages provide a transient muscle stem cell niche via NAMPT secretion
Use of the MyProstateScore test to rule out clinically significant cancer: validation of a straightforward clinical testing approach
Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas
Genome evolution and the emergence of pathogenicity in avian Escherichia coli
Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis
Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
Lenvatinib plus pembrolizumab or everolimus for advanced renal cell carcinoma
Agonist-antagonist myoneural interface amputation preserves proprioceptive sensorimotor neurophysiology in lower limbs
Neural interfacing architecture enables enhanced motor control and residual limb functionality postamputation
Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors
Tibiofemoral bony morphology features associated with ACL injury and sex utilizing three-dimensional statistical shape modeling
A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance
Nrf2 and β-catenin coactivation in hepatocellular cancer: Biological and therapeutic implications
Scaffolding protein IQGAP1 is dispensable but its overexpression promotes hepatocellular carcinoma via YAP1 signaling
Barriers to kidney transplantation in racial/ethnic minorities
Social determinants of health and race disparities in kidney transplant
ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism
TALEN outperforms Cas9 in editing heterochromatin target sites
The association of dilated perivascular spaces with cognitive decline and incident dementia
Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance
AIM2 in regulatory T cells restrains autoimmune diseases
Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses
Somatic reversion of pathogenic DOCK8 variants alters lymphocyte differentiation and function to effectively cure DOCK8 deficiency
Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration
Differentiation of the 50B11 dorsal root ganglion cells into NGF and GDNF responsive nociceptor subtypes
Clinical performance and utility of a comprehensive next-generation sequencing DNA panel for the simultaneous analysis of variants, TMB and MSI for myeloid neoplasms
Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models
AMPK induces regulatory innate lymphoid cells after traumatic brain injury
Gut-licensed IFNγ NK cells drive LAMP1 TRAIL anti-inflammatory astrocytes
Targeting OCT3 attenuates doxorubicin-induced cardiac injury
Association of ambient air pollution with age-related macular degeneration and retinal thickness in UK Biobank
The Apex bileaflet mechanical heart valve
Soft subdermal implant capable of wireless battery charging and programmable controls for applications in optogenetics
Bacterial and fungal profiles as markers of infliximab drug response in inflammatory bowel disease
Synthetic bone‐like structures through omnidirectional ceramic bioprinting in cell suspensions
Evolution of antibody immunity to SARS-CoV-2
Extracellular vesicles promote transkingdom nutrient transfer during viral-bacterial co-infection
Adaptive remodeling in the elastase-induced rabbit aneurysms
Actin-binding protein profilin1 promotes aggressiveness of clear-cell renal cell carcinoma cells
Prioritized research for the prevention, treatment, and reversal of chronic disease: recommendations from the Lifestyle Medicine Research Summit
In-vivo efficacy of biodegradable ultrahigh ductility Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction
EGR1 is a gatekeeper of inflammatory enhancers in human macrophages
Cabozantinib for neurofibromatosis type 1related plexiform neurofibromas: a phase 2 trial
Referral rates for cardiac rehabilitation among eligible inpatients after implementation of a default opt-out decision pathway in the electronic medical record
Epigenetic targeting of Waldenström macroglobulinemia cells with BET inhibitors synergizes with BCL2 or histone deacetylase inhibition
Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient C. elegans
Targeting cartilage EGFR pathway for osteoarthritis treatment
Emergency response for evaluating SARS-CoV-2 immune status, seroprevalence and convalescent plasma in Argentina
Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice
Learning the language of viral evolution and escape
Post-transcriptional gene regulation by microRNA-194 promotes neuroendocrine transdifferentiation in prostate cancer
Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche
The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6
Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse model
A pro-carcinogenic colon microbe promotes breast tumorigenesis and metastatic progression and concomitantly activates Notch and βcatenin axes
How do the blind 'see'? The role of spontaneous brain activity in self-generated perception
The SIRPαCD47 immune checkpoint in NK cells
Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities
A single immunization with spike-functionalized ferritin vaccines elicits neutralizing antibody responses against SARS-CoV-2 in mice
Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin
Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates
ECM hydrogel improves the delivery of PEG microsphere-encapsulated neural stem cells and endothelial cells into tissue cavities caused by stroke
Smaller regional brain volumes predict posttraumatic stress disorder at 3 months after mild traumatic brain injury
Oral azacitidine maintenance therapy for acute myeloid leukemia in first remission
Metastasis and immune evasion from extracellular cGAMP hydrolysis
Stopping renin-angiotensin system inhibitors in patients with advanced CKD and risk of adverse outcomes: a nationwide study
The neural mechanisms underlying processing speed deficits in individuals who have sustained a spinal cord injury: a pilot study
STING agonist promotes CAR T cell trafficking and persistence in breast cancer
Blocking pro-inflammatory platelet-activating factor receptors and activating cell survival pathways: A novel therapeutic strategy in experimental ischemic stroke
Distinct developmental pathways from blood monocytes generate human lung macrophage diversity
Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity
Identification and characterization of novel bronchodilator agonists acting at human airway smooth muscle cell TAS2R5
IspH inhibitors kill gram-negative bacteria and mobilize immune clearance
Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils
Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue
Glycoengineering of NK cells with glycan ligands of CD22 and selectins for B‐cell lymphoma therapy
Long-range phase synchronization of high-frequency oscillations in human cortex
Gene dosage manipulation alleviates manifestations of hereditary PAX6 haploinsufficiency in mice
A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus
Extraembryonic endoderm (XEN) cells capable of contributing to embryonic chimeras established from pig embryos
Rheological investigation of collagen, fibrinogen, and thrombin solutions for drop-on-demand 3D bioprinting
Quinine copolymer reporters promote efficient intracellular DNA delivery and illuminate a protein-induced unpackaging mechanism
Synergistic combination of calcium and citrate in mesoporous nanoparticles targets pleural tumors
Neurologic syndromes predict higher in-hospital mortality in COVID-19
Dissociating antibacterial from ototoxic effects of gentamicin C-subtypes
Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy
Revealing nanoscale mineralization pathways of hydroxyapatite using in situ liquid cell transmission electron microscopy
Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study
Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study
Pharmacological reversal of synaptic and network pathology in human MECP2 ‐KO neurons and cortical organoids
The trans-kingdom battle between donor and recipient gut microbiome influences fecal microbiota transplantation outcome
Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system
Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells
Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade
Durable suppression of acquired MEK inhibitor resistance in cancer by sequestering MEK from ERK and promoting anti-tumor T-cell immunity
Human‐specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression
Survival and recurrence after intraperitoneal chemotherapy use: Retrospective review of ovarian cancer hospital registry data
Developmental remodelling of non-CG methylation at satellite DNA repeats
Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling
Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis
COVID-19 severity is tripled in the diabetes community: a prospective analysis of the pandemics impact in type 1 and type 2 diabetes
Integration of genomics and transcriptomics predicts diabetic retinopathy susceptibility genes
Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
Senescence-associated secretory phenotype determines survival and therapeutic response in cervical cancer
CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimers disease
Structural basis for α‐helix mimicry and inhibition of proteinprotein interactions with oligourea foldamers
Targeted deubiquitination rescues distinct trafficking-deficient ion channelopathies
Gene regulatory network analysis and engineering directs development and vascularization of multilineage human liver organoids
Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation
PD1 blockade enhances K channel activity, Ca2 signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer
Optimized OPA1 Isoforms 1 and 7 provide therapeutic benefit in models of mitochondrial dysfunction
Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase ρ
RNA-mediated control of cell shape modulates antibiotic resistance in Vibrio cholerae
Mucosal immunity in COVID-19: a neglected but critical aspect of SARS-CoV-2 infection
Inhibition of 3-phosphoinositidedependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts
Accelerating bone healing in vivo by harnessing the age-altered activation of c-Jun N-terminal kinase 3
Gut microbiota depletion by chronic antibiotic treatment alters the sleep/wake architecture and sleep EEG power spectra in mice
Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma
Associations between physical activity and changes in depressive symptoms and health-related quality of life across 7 years following roux-en-y gastric bypass surgery--a multicenter prospective cohort study
FRESH 3D bioprinting a full-size model of the human heart
Mavacamten favorably impacts cardiac structure in obstructive hypertrophic cardiomyopathy: EXPLORER-HCM CMR substudy analysis
Time, pattern, and outcome of medulloblastoma relapse and their association with tumour biology at diagnosis and therapy: a multicentre cohort study
Acceleration of biomolecule enrichment and detection with rotationally motorized opto-plasmonic microsensors and the working mechanism
Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs
Cancer-associated gain-of-function mutations activate a SWI/SNF-family regulatory hub
Pharmacological validation of targets regulating CD14 during macrophage differentiation
Tissue topography steers migrating Drosophila border cells
Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells
Increasing kinase domain proximity promotes MST2 autophosphorylation during Hippo signaling
Bone marrow adipogenic lineage precursors (MALPs) promote osteoclastogenesis in bone remodeling and pathologic bone loss
Three-dimensional directional nerve guide conduits fabricated by dopamine-functionalized conductive carbon nanofibre-based nanocomposite ink printing
Viscoelastic properties of biopolymer hydrogels determined by Brillouin spectroscopy: A probe of tissue micromechanics
Suppression of DNA double-strand break formation by DNA polymerase β in active DNA demethylation is required for development of hippocampal pyramidal neurons
Bundle analytics, a computational framework for investigating the shapes and profiles of brain pathways across populations
Integrated morphoelectric and transcriptomic classification of cortical GABAergic cells
Whole-genome sequencing and gene network modules predict gemcitabine/carboplatin-induced myelosuppression in non-small cell lung cancer patients
Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation
Repetitive elements trigger RIG-I-like receptor signaling that regulates the emergence of hematopoietic stem and progenitor cells
JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
The potassium channel subunit Kvβ1 serves as a major control point for synaptic facilitation
Effect of hydroxychloroquine on clinical status at 14 days in hospitalized patients with COVID-19--a randomized clinical trial
Variant-to-gene-mapping analyses reveal a role for the hypothalamus in genetic susceptibility to inflammatory bowel disease
A randomised controlled feasibility trial of E-health application supported care vs usual care after exacerbation of COPD: the RESCUE trial
Network-based machine learning in colorectal and bladder organoid models predicts anti-cancer drug efficacy in patients
Changes in membrane dielectric properties of porcine kidney cells provide insight into the antiviral activity of glycine
An epicardial bioelectronic patch made from soft rubbery materials and capable of spatiotemporal mapping of electrophysiological activity
Bacterial retrons function in anti-phage defense
Heterozygous cystic fibrosis transmembrane regulator gene missense variants are associated with worse cardiac function in patients with Duchenne Muscular Dystrophy
Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription
3D bioprinted highly elastic hybrid constructs for advanced fibrocartilaginous tissue regeneration
Diagnostics of melanocytic skin tumors by a combination of ultrasonic, dermatoscopic and spectrophotometric image parameters
Evolving trends in adult heart transplant with the 2018 heart allocation policy change
Visualizing a protonated RNA state that modulates microRNA-21 maturation
Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases
Tunable dynamics of B cell selection in gut germinal centres
A human tissue screen identifies a regulator of ER secretion as a brain size determinant
Physical traits of cancer
IL6 fuels durable memory for Th17 cellmediated responses to tumors
Conditional protein tagging methods reveal highly specific subcellular distribution of ion channels in motion-sensing neurons
Structural neuroplastic responses preserve functional connectivity and neurobehavioural outcomes in children born without corpus callosum
Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2
Early emergence of T central memory precursors programs clonal dominance during chronic viral infection
Development and validation of a clinical prognostic stage group system for nonmetastatic prostate cancer using disease-specific mortality results from the international staging collaboration for cancer of the prostate
Predicting drug response and synergy using a deep learning model of human cancer cells
Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells from protective bone marrow niches
Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer
The DEL-1/β3 integrin axis promotes regulatory T cell responses during inflammation resolution
Somatic mutations in UBA1 and severe adult-onset autoinflammatory disease
Exploring high aspect ratio gold nanotubes as cytosolic agents: structural engineering and uptake into mesothelioma cells
Bilateral distance partition of periventricular and deep white matter hyperintensities: performance of the method in the aging brain
Metabolomics profiling of critically ill coronavirus disease 2019 patients: identification of diagnostic and prognostic biomarkers
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression
Validation of a core patient-reported outcome measure for fatigue in patients receiving hemodialysis
The VASP-profilin1 (Pfn1) interaction is critical for efficient cell migration and is regulated by cell-substrate adhesion in a PKA-dependent manner
TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin
Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study
Long‐term survival of participants in the CENTAUR trial of sodium phenylbutyrate‐taurursodiol in ALS
Positive selection within the genomes of SARS-CoV-2 and other Coronaviruses independent of impact on protein function
Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation
Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices
The nucleus acts as a ruler tailoring cell responses to spatial constraints
Dynamic bio‐barcode assay enables electrochemical detection of a cancer biomarker in undiluted human plasma: a sample‐in‐answer‐out approach
eIF2α controls memory consolidation via excitatory and somatostatin neurons
Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip
Disease trajectory browser for exploring temporal, population-wide disease progression patterns in 7.2 million Danish patients
Gene regulatory networks controlling vertebrate retinal regeneration
High‐throughput magnetic actuation platform for evaluating the effect of mechanical force on 3D tumor microenvironment
Silk fibroin nanofibers: a promising ink additive for extrusion three-dimensional bioprinting
Fine structural tuning of the assembly of ECM peptide conjugates via slight sequence modifications
Monoclonal immunoglobulins promote bone loss in multiple myeloma
MP-Pt(IV): A MAOB-sensitive mitochondrial-specific prodrug for treating glioblastoma
Expansion of the phenotypic spectrum of de novo missense variants in kinesin family member 1A (KIF1A)
Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants
Nonfatal opioid overdoses at an urban emergency department during the COVID-19 pandemic
Excess deaths from COVID-19 and other causes, March-April 2020
Excess deaths from COVID-19 and other causes, March-July 2020
Theory of mechanochemical patterning and optimal migration in cell monolayers
A pathoconnectome of early neurodegeneration: Network changes in retinal degeneration
Tumoural activation of TLR3SLIT2 axis in endothelium drives metastasis
Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells
Maresin-1 and Resolvin E1 promote regenerative properties of periodontal ligament stem cells under inflammatory conditions
Real-world data from a molecular tumor board demonstrates improved outcomes with a precision N-of-One strategy
Systolic blood pressure reduction and acute kidney injury in intracerebral hemorrhage
Combinational therapy with antibiotics and antibiotic-loaded adipose-derived stem cells reduce abscess formation in implant-related infection in rats
Non-invasive molecularly-specific millimeter-resolution manipulation of brain circuits by ultrasound-mediated aggregation and uncaging of drug carriers
Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity
Progressing the field of Regenerative Rehabilitation through novel interdisciplinary interaction
Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation
Protein aggregation and immunogenicity of biotherapeutics
Untethered control of functional origami microrobots with distributed actuation
Brain-first versus body-first Parkinsons disease: a multimodal imaging case-control study
Enhanced treatment strategies and distinct disease outcomes among autoantibody-positive and -negative rheumatoid arthritis patients over 25 years: A longitudinal cohort study in the Netherlands
Patient trajectories among persons hospitalized for COVID-19
Obesity is associated with reduced plasticity of the human motor cortex
A role for astroglial calcium in mammalian sleep and sleep regulation
Extracorporeal membrane oxygenation support in COVID-19: an international cohort study of the Extracorporeal Life Support Organization registry
Ethnic differences in alpha‐1 antitrypsin deficiency allele frequencies may partially explain national differences in COVID‐19 fatality rates
Regulatory T cells suppress Th17 cell Ca2 signaling in the spinal cord during murine autoimmune neuroinflammation
Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
Enabling early detection of osteoarthritis from presymptomatic cartilage texture maps via transport-based learning
Mesoscale diffusion magnetic resonance imaging of the ex vivo human hippocampus
Fully oxygen-tolerant atom transfer radical polymerization triggered by sodium pyruvate
Point-of-care platform blood biomarker testing of glial fibrillary acidic protein versus S100 calcium-binding protein B for prediction of traumatic brain injuries: a transforming research and clinical knowledge in traumatic brain injury study
Cells from discarded dressings differentiate chronic from acute wounds in patients with Epidermolysis Bullosa
Glial metabolic rewiring promotes axon regeneration and functional recovery in the central nervous system
Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates
Increased antioxidant capacity and pro-homeostatic lipid mediators in ocular hypertensiona human experimental model
Astrocytes are necessary for bloodbrain barrier maintenance in the adult mouse brain
Identification of a nanomolar affinity α-synuclein fibril imaging probe by ultra-high throughput in silico screening
Epineural optogenetic activation of nociceptors initiates and amplifies inflammation
Machine learning guided 3D printing of tissue engineering scaffolds
Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination
Heterochromatin-driven nuclear softening protects the genome against mechanical stress-induced damage
Excess patient visits for cough and pulmonary disease at a large US health system in the months prior to the COVID-19 pandemic: time-series analysis
Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes
A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinsons disease
Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer
Most commonly mutated genes in high-grade serous ovarian carcinoma are nonessential for ovarian surface epithelial stem cell transformation
Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in myofibroblast differentiation
Determinants of telomere length across human tissues
GFI1 functions to repress neuronal gene expression in the developing inner ear hair cells
Porous microneedles on a paper for screening test of prediabetes
Microfluidic label-free bioprocessing of human reticulocytes from erythroid culture
Decidual vasculopathy identification in whole slide images using multiresolution hierarchical convolutional neural networks
Improved testing and design of intubation boxes during the COVID-19 pandemic
Effect of hydrocortisone on mortality and organ support in patients with severe COVID-19. The REMAP-CAP COVID-19 corticosteroid domain randomized clinical trial.
Synthetic immunomodulation with a CRISPR super-repressor in vivo
ACTIVATE: Randomized clinical trial of BCG vaccination against infection in the elderly
Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors
Multiphase assembly of small molecule microcrystalline peptide hydrogel allows immunomodulatory combination therapy for long‐term heart transplant survival
An in vitro model of chronic wounding and its implication for age-related macular degeneration
Smad7 enhances TGF-β-induced transcription of c-Jun and HDAC6 promoting invasion of prostate cancer cells
A cell-autonomous signature of dysregulated protein phosphorylation underlies muscle insulin resistance in type 2 diabetes
Structure of a human 48S translational initiation complex
Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations
Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients
Association of anticholinergic medication and AD biomarkers with incidence of MCI among cognitively normal older adults
Host lymphotoxin-β receptor signaling is crucial for angiogenesis of metanephric tissue transplanted into lymphoid sites
Kidneyinalymph node: A novel organogenesis assay to model human renal development and test nephron progenitor cell fates
Ex vivo cell therapy by ectopic hepatocyte transplantation treats the porcine tyrosinemia model of acute liver failure
Single-cell transcriptome analysis of colon cancer cell response to 5-fluorouracil-induced DNA damage
Sustained release of a GLP-1 and FGF21 dual agonist from an injectable 2 depot protects mice from obesity and hyperglycemia
Phase 1 study of TTC-352 in patients with metastatic breast cancer progressing on endocrine and CDK4/6 inhibitor therapy
Atomistic structure and dynamics of the human MHC-I peptide-loading complex
SARS-CoV-2 infectivity and neurological targets in the brain
3D printed patient-specific aortic root models with internal sensors for minimally invasive applications
2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease: The Task Force on sports cardiology and exercise in patients with cardiovascular disease of the European Society of Cardiology (ESC)
IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome
A synthetic synaptic organizer protein restores glutamatergic neuronal circuits
Engineered spider silk-based 2D and 3D materials prevent microbial infestation
Development of ectopic livers by hepatocyte transplantation into swine lymph nodes
High‐protein diet more effectively reduces hepatic fat than low‐protein diet despite lower autophagy and FGF21 levels
Immune-modulatory alginate protects mesenchymal stem cells for sustained delivery of reparative factors to ischemic myocardium
Distinct regulatory programs control the latent regenerative potential of dermal fibroblasts during wound healing
Engineered off-the-shelf therapeutic T cells resist host immune rejection
PKD1-dependent renal cystogenesis in human induced pluripotent stem cell-derived ureteric bud/collecting duct organoids
A single-dose intranasal ChAd vaccine protects upper and lower respiratory tracts against SARS-CoV-2
Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA foldsmall molecule interactions
EEF1A1 deacetylation enables transcriptional activation of remyelination
1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation
The gut virome database reveals age-dependent patterns of virome diversity in the human gut
Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis in mice
Sex differences in pharmacokinetics predict adverse drug reactions in women
Integrated metabolic and epigenomic reprograming by H3K27M mutations in diffuse intrinsic pontine gliomas
Co‐occurrence of antibiotic, biocide, and heavy metal resistance genes in bacteria from metal and radionuclide contaminated soils at the Savannah River Site
Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
Immune monitoring facilitates the clinical decision in multifocal COVID‐19 of a pancreas‐kidney transplant patient
Enabling and promoting walking rehabilitation by paired associative stimulation after incomplete paraplegia: a case report
Prognostic gene expression signature for high-grade serous ovarian cancer
Mitochondrial dynamics in postmitotic cells regulate neurogenesis
Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk
Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
Differential recovery rates of fitness following U.S. Army Ranger training
Hydrogel−solid hybrid materials for biomedical applications enabled by surface‐embedded radicals
Temporal pressure enhanced topical drug delivery through micropore formation
Cxcl9l and Cxcr3.2 regulate recruitment of osteoclast progenitors to bone matrix in a medaka osteoporosis model
Insulin2Q104del (Kuma) mutant mice develop diabetes with dominant inheritance
DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke
The association between biomarkers and clinical outcomes in novel coronavirus pneumonia in a US cohort
A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein
Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive Faecalibacterium prausnitzii in continuous culture
Abnormal liver tests in COVID‐19: a retrospective observational cohort study of 1827 patients in a major U.S. hospital network
A short de novo synthesis of nucleoside analogs
Flexible usage and interconnectivity of diverse cell death pathways protect against intracellular infection
DNA capture by a CRISPR-Cas9guided adenine base editor
VRK-1 extends life span by activation of AMPK via phosphorylation
The architecture and stabilisation of flagellotropic tailed bacteriophages
A unified catalog of 204,938 reference genomes from the human gut microbiome
Identification of an anti-diabetic, orally available small molecule that regulates TXNIP expression and glucagon action
Surface tension nanogates for controlled ion transport
PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas
Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase
The optic nerve lamina region is a neural progenitor cell niche
Breast reconstruction using a 3-dimensional absorbable mesh scaffold and autologous fat grafting: a composite strategy using tissue engineering principles
Characterization of astrocytic response after experiencing cavitation in vitro
The cytokine IL-17A limits Th17 pathogenicity via a negative feedback loop driven by autocrine induction of IL-24
Phage therapy for limb-threatening prosthetic knee klebsiella pneumoniae infection: case report and in vitro characterization of anti-biofilm activity
Asymmetric clustering of centrosomes defines the early evolution of tetraploid cells
Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia
Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells
Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors
CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells
Temporal signatures of criticality in human cortical excitability as probed by early somatosensory responses
Developmental attenuation of neuronal apoptosis by neural-specific splicing of Bak1 microexon
3D printing of microgel‐loaded modular microcages as instructive scaffolds for tissue engineering
Depicting brighter possibilities for treating blindness
A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma
Standard gastroenterologist versus multidisciplinary treatment for functional gastrointestinal disorders (MANTRA): an open-label, single-centre, randomised controlled trial
Microrheological characterization of covalent adaptable hydrogel degradation in response to temporal pH changes that mimic the gastrointestinal tract
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development
Reliability and validity of an enhanced paper grip test; a simple clinical test for assessing lower limb strength
Magnetic vortex nanodiscs enable remote magnetomechanical neural stimulation
Maltotriose conjugated metalorganic frameworks for selective targeting and photodynamic therapy of triple negative breast cancer cells and tumor associated macrophages
Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
Encouraging results from phase 1/2 COVID-19 vaccine trials
Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomized, double-blind, placebo-controlled, phase 2 trial
An mRNA vaccine against SARS-CoV-2 -- preliminary report
Sensory restoration by epidural stimulation of the lateral spinal cord in upper-limb amputees
Heart transplantation from biventricular support in infant with novel SMYD1 mutation
Evaluation of a simulation-based mini-elective on medical student interest in cardiac surgery
Young eosinophils rejuvenate ageing adipose tissues
Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age
Suprachoroidal gene transfer with nonviral nanoparticles
Excessive astrocytic GABA causes cortical hypometabolism and impedes functional recovery after subcortical stroke
Synaptic plasticity induced by differential manipulation of tonic and phasic motoneurons in Drosophila
Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles
A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination
Extrapulmonary manifestations of COVID-19
Quantitative cellular-resolution map of the oxytocin receptor in postnatally developing mouse brains
Positional isomers of a non-nucleoside substrate differentially affect myosin function
Reduced-intensity single-unit unrelated cord blood transplant with optional immune boost for nonmalignant disorders
Remote nongenetic optical modulation of neuronal activity using fuzzy graphene
In situ electrochemical generation of nitric oxide for neuronal modulation
Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression
Abnormal scaffold attachment factor 1 expression and localisation in spinocerebellar ataxias and Huntingtons chorea
Chemical gradients in human enamel crystallites
Repeated FIB-4 measurements can help identify individuals at risk of severe liver disease
Single-dose mRNA therapy via biomaterial-mediated sequestration of overexpressed proteins
Type V collagen in scar tissue regulates the size of scar after heart injury
PARGT: a software tool for predicting antimicrobial resistance in bacteria
Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease
Relationship between oxygen consumption and neuronal activity in a defined neural circuit
Enhancement of abiraterone acetate oral bioavailability by supersaturated-silica lipid hybrids
Mesencephalic astrocytederived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart
Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
Targeted delivery of mitochondria to the liver in rats
Serum urate lowering with allopurinol and kidney function in type 1 diabetes
Economic evaluation of Faecal microbiota transplantation compared to antibiotics for the treatment of recurrent Clostridioides difficile infection
Studies on the mechanisms of anti-inflammatory activity of heparin- and hyaluronan-containing multilayer coatingstargeting NF-κB signalling pathway
Infectability of human brainsphere neurons suggests neurotropism of SARS-CoV-2
Epicardial transplantation of atrial appendage micrograft patch salvages myocardium after infarction
Hybrid gene origination creates human-virus chimeric proteins during infection
Fibroblasttumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways
Patient genetics is linked to chronic wound microbiome composition and healing
Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
Deconstructing sarcomeric structurefunction relations in titin-BioID knock-in mice
Use of the prevented fraction for the population to determine deaths averted by existing prevalence of physical activity: a descriptive study
Partitioning of cancer therapeutics in nuclear condensates
The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides
Targeted phototherapy for malignant pleural mesothelioma: near-infrared photoimmunotherapy targeting podoplanin
Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin
Very fast CRISPR on demand
Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death
Lipidomics and RNA sequencing reveal a novel subpopulation of nanovesicle within extracellular matrix biomaterials
A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies
ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function
Retinal ganglion cells with a glaucoma OPTN(E50K) mutation exhibit neurodegenerative phenotypes when derived from three-dimensional retinal organoids
MHC class I and II peptide homology regulates the cellular immune response
Skeletal muscle antagonizes antiviral CD8 T cell exhaustion
Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature
Association of circadian abnormalities in older adults with an increased risk of developing Parkinson Disease
Bioresorbable, miniaturized porous silicon needles on a flexible water-soluble backing for unobtrusive, sustained delivery of chemotherapy
Tumour predisposition and cancer syndromes as models to study geneenvironment interactions
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
Untangling the potential of carbon quantum dots in neurodegenerative disease
TMEM16A deficiency: a potentially fatal neonatal disease resulting from impaired chloride currents
Photoenzymatic enantioselective intermolecular radical hydroalkylation
Cephalopod-inspired optical engineering of human cells
Restoring light sensitivity using tunable near-infrared sensors
Development of CRISPR as an antiviral strategy to combat SARS-CoV-2 and influenza
Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer
Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice
Magnetoelectric materials for miniature, wireless neural stimulation at therapeutic frequencies
Nucleosides rescue replication-mediated genome instability of human pluripotent stem cells
PIRs mediate innate myeloid cell memory to nonself MHC molecules
Biological and clinical characteristics of gene carriers far from predicted onset in the Huntington's disease Young Adult Study (HD-YAS): a cross-sectional analysis
PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function
Hepatic NADH reductive stress underlies common variation in metabolic traits
Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism
Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
Characterization of the development of the mouse cochlear epithelium at the single cell level
Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with high-dose methotrexate plus intrathecal chemotherapy for newly diagnosed intravascular large B-cell lymphoma (PRIMEUR-IVL): a multicentre, single-arm, phase 2 trial
Americans COVID-19 stress, coping, and adherence to CDC guidelines
Synaptic actions of Amyotrophic Lateral Sclerosis-associated G85R-SOD1 in the squid giant synapse
STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy
Assembly and function of a bioengineered human liver for transplantation generated solely from induced pluripotent stem cells
Use of ECCO2R with the Hemolung RAS in the treatment of severe hypercapnic respiratory failure caused by SARS-CoV-2 acute lung injury
Decellularization techniques and their applications for the repair and regeneration of the nervous system
Control of ecological outcomes through deliberate parameter changes in a model of the gut microbiome
Reconfigurations within resonating communities of brain regions following TMS reveal different scales of processing
De novo protein design enables the precise induction of RSV-neutralizing antibodies
Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance
Toward neuroprosthetic real-time communication from in silico to biological neuronal network via patterned optogenetic stimulation
Acetylation of Aβ42 at lysine 16 disrupts amyloid formation
Exploring theoretical and experimental optimization towards high-performance triboelectric nanogenerators using microarchitecture silk cocoon films
Triterpenoid acids isolated from Schinus terebinthifolia fruits reduce Staphylococcus aureus virulence and abate dermonecrosis
Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomized, first-in-human trial
Common germline variants of the human APOE gene modulate melanoma progression and survival
In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET
Variants that affect function of calcium channel TRPV6 are associated with early-onset chronic pancreatitis
Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomized controlled trial
Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data
Targeting two-component systems uncovers a small-molecule inhibitor of Salmonella virulence
Multimodal coherent imaging of retinal biomarkers of Alzheimers disease in a mouse model
Influence of pre-freezing conditions of octacalcium phosphate and collagen composite for reproducible appositional bone formation
Cardiovascular complications in COVID-19
MicroRNA-9 fine-tunes dendritic cell function by suppressing negative regulators in a cell-type-specific manner
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimers disease
General anesthetics activate a potent central pain-suppression circuit in the amygdala
Examination of food consumption in United States adults and the prevalence of inflammatory bowel disease using National Health Interview Survey 2015
Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease
Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells
Mitochondrial fission mediates endothelial inflammation
Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets
ST2 as checkpoint target for colorectal cancer immunotherapy
An occult HPV-driven oropharyngeal squamous cell carcinoma discovered through a saliva test
Real-time tracking of self-reported symptoms to predict potential COVID-19
A non-canonical inhibitory circuit dampens behavioral sensitivity to light
Upregulating Lin28a promotes axon regeneration in adult mice with optic nerve and spinal cord injury
Dual-functional plasmonic photothermal biosensors for highly accurate severe acute respiratory syndrome coronavirus 2 detection
B-type natriuretic peptide is upregulated by c-Jun N-terminal kinase and contributes to septic hypotension
Separase-triggered apoptosis enforces minimal length of mitosis
Region-specific transcriptional control of astrocyte function oversees local circuit activities
Pandemics and the great evolutionary mismatch
3D characterisation of dry powder inhaler formulations: Developing X-ray micro computed tomography approaches
Hippocampal synaptic plasticity, spatial memory, and neurotransmitter receptor expression are profoundly altered by gradual loss of hearing ability
Cathepsin S regulates antigen processing and T cell activity in non-Hodgkin lymphoma
Structural basis for transcriptional start site control of HIV-1 RNA fate
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
Can keratin scaffolds be used for creating three-dimensional cell cultures?
Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells
A segregated cortical stream for retinal direction selectivity
Tuft cell formation reflects epithelial plasticity in pancreatic injury: implications for modeling human pancreatitis
Molecular and cellular differences in cardiac repair of male and female mice
Selective PP2A enhancement through biased heterotrimer stabilization
Deep learning method for mandibular canal segmentation in dental cone beam computed tomography volumes
Circulating cell-free DNA is predominantly composed of retrotransposable elements and non-telomeric satellite DNA
Evaluation of host-based molecular markers for the early detection of human sepsis
Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin
Identification of calcium and integrin‐binding protein 1 as a novel regulator of production of amyloid β peptide using CRISPR/Cas9‐based screening system
An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs
Vascular supply of the human spiral ganglion: novel three-dimensional analysis using synchrotron phase-contrast imaging and histology
FABP4: a new player in obesity-associated breast cancer
A CRISPR-based assay for the detection of opportunistic infections post-transplantation and for the monitoring of transplant rejection
Loss of ELF5FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling
Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity
Minimum epistasis interpolation for sequence-function relationships
Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4 T cells to cytokines
Single-dose, intranasal immunization with recombinant parainfluenza virus 5 expressing middle east respiratory syndrome coronavirus (MERS-CoV) spike protein protects mice from fatal MERS-CoV infection
Activity in grafted human iPS cellderived cortical neurons integrated in stroke-injured rat brain regulates motor behavior
Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1
Optimizing the trade-off between learning and doing in a pandemic
Fusing randomized trials with big data the key to self-learning health care systems?
The randomized embedded multifactorial adaptive platform for community-acquired pneumonia (REMAP-CAP) study: rationale and design
Cardiac myosin promotes thrombin generation and coagulation in vitro and in vivo
Cysteine depletion induces pancreatic tumor ferroptosis in mice
Application of mild hypothermia successfully mitigates neural injury in a 3D in-vitro model of traumatic brain injury
Recapitulating the human segmentation clock with pluripotent stem cells
Myosin II filament dynamics in actin networks revealed with interferometric scattering microscopy
A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination
Ligand-mediated targeting of cytokine Interleukin-27 enhances its bioactivity in vivo
SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells
Grip strength cut points for diabetes risk among apparently healthy U.S. adults
Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2
Twist again: Dynamically and reversibly controllable chirality in liquid crystalline elastomer microposts
Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development
Deep remission at 1 year prevents progression of early Crohns disease
Discovery of a novel integron-borne aminoglycoside resistance gene present in clinical pathogens by screening environmental bacterial communities
Regulation of biomolecular-motor-driven cargo transport by microtubules under mechanical stress
Association between cardiovascular disease and long-term exposure to air pollution with the risk of dementia
The pan-cancer landscape of prognostic germline variants in 10,582 patients
Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA
Sugar-induced obesity and insulin resistance are uncoupled from shortened survival in drosophila
Effect of different exercise programs on non-specific chronic low back pain and disability in people who perform sedentary work
Ultrasensitive detection of nucleic acids using deformed graphene channel field effect biosensors
Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
New systematic therapies and trends in cutaneous melanoma deaths among US whites, 19862016
Defining epidermal basal cell states during skin homeostasis and wound healing using single-cell transcriptomics
Identification of nonsmall cell lung cancer sensitive to systemic cancer therapies using radiomics
Precontrolled alignment of graphite nanoplatelets in polymeric composites prevents bacterial attachment
Potently cytotoxic natural killer cells initially emerge from erythro-myeloid progenitors during mammalian development
Human dental pulp stem cells exhibit enhanced properties in comparison to human bone marrow stem cells on neurites outgrowth
Ameloblastomas exhibit stem cell potential, possess neurotrophic properties, and establish connections with trigeminal neurons
Short-term modulation of the lesioned language network
Functional recombinant apolipoprotein A5 that is stable at high concentrations at physiological pH
Multi-scale predictions of drug resistance epidemiology identify design principles for rational drug design
Microbiome analyses of blood and tissues suggest cancer diagnostic approach
Treg-inducing microparticles promote donor-specific tolerance in experimental vascularized composite allotransplantation
In situ recruitment of regulatory T cells promotes donor-specific tolerance in vascularized composite allotransplantation
Impacts of Intralipid on nanodrug Abraxane therapy and on the innate immune system
AAV gene therapy prevents and reverses heart failure in a murine knockout model of Barth Syndrome
Multi-omics analysis of the intermittent fasting response in mice identifies an unexpected role for HNF4alpha
Generation of human endothelium in pig embryos deficient in ETV2
Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM
Cardiopoietic stem cell therapy restores infarction-altered cardiac proteome
Analysis of DNA methylation associates the cystineglutamate antiporter SLC7A11 with risk of Parkinsons disease
Tough ordered mesoporous elastomeric biomaterials formed at ambient conditions
Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling
Pan-cancer diagnostic consensus through searching archival histopathology images using artificial intelligence
Serial interval of COVID-19 from publicly reported confirmed cases
Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices
Photobactericidal activity activated by thiolated gold nanoclusters at low flux levels of white light
Perivascular osteoprogenitors are associated with transcortical channels of long bones
Biphasic chemotaxis of Escherichia coli to the microbiota metabolite indole
Local targeted memory reactivation in human sleep
Full-waveform inversion imaging of the human brain
Structural basis of nucleosome assembly by the Abo1 AAA ATPase histone chaperone
Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina
A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure
A regenerative peripheral nerve interface allows real-time control of an artificial hand in upper limb amputees
Toll‐like receptor 4 signaling in neurons enhances calcium‐permeable α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor currents and drives post‐traumatic epileptogenesis
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
Dual microglia effects on blood brain barrier permeability induced by systemic inflammation
A cell atlas of human thymic development defines T cell repertoire formation
Perceived healthiness of food items and the traffic light front of pack nutrition labelling: choice‐based conjoint analysis and cross‐sectional survey
Complex human adenoid tissue-based ex vivo culture systems reveal anti-inflammatory drug effects on germinal center T and B cells
Physiological tolerance to ssDNA enables strand uncoupling during DNA replication
Early transmission dynamics in Wuhan, China, of novel coronavirusinfected pneumonia
COVID-19: Navigating the uncharted
Knockdown of long noncoding RNAs hepatocyte nuclear factor 1α antisense RNA 1 and hepatocyte nuclear factor 4α antisense RNA 1 alters susceptibility of acetaminophen-induced cytotoxicity in HepaRG cells
Acetaminophen-induced liver injury alters expression and activities of cytochrome P450 enzymes in an age-dependent manner in mouse liver
Lamina-dependent stretching and unconventional chromosome compartments in early C. elegans embryos
A drug discovery platform to identify compounds that inhibit EGFR triple mutants
Experimental glaucoma model with controllable intraocular pressure history
Trypanosoma brucei Pex13.2 is an accessory peroxin that functions in the import of peroxisome targeting sequence type 2 proteins and localizes to subdomains of the glycosome
High-throughput identification of post-transcriptional utrophin up-regulators for Duchenne muscle dystrophy (DMD) therapy
Oral delivery of novel human IGF-1 bioencapsulated in lettuce cells promotes musculoskeletal cell proliferation, differentiation and diabetic fracture healing
Continuous wearable monitoring analytics predict heart failure hospitalization
Dysbiosis-induced secondary bile acid deficiency promotes intestinal inflammation
Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits
A cell atlas of human thymic development defines T cell repertoire formation
A deep learning approach to antibiotic discovery
Deformation of transvaginal mesh in response to multiaxial loading
Urinary auto-brewery syndrome: a case report
Opto-chemo-mechanical transduction in photoresponsive gels elicits switchable self-trapped beams with remote interactions
Changes in smoking behavior before and after gastric bypass--a 7-year study
Emerging patent landscape for non-viral vectors used for gene therapy
Teprotumumab for the treatment of active thyroid eye disease
The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer
Comparative molecular life history of spontaneous canine and human gliomas
Human textiles: A cell-synthesized yarn as a truly bio material for tissue engineering applications
Hyaluronic acid-based hydrogels with independently tunable mechanical and bioactive signaling features
Analysis of interactions stabilized by Fusicoccin A reveals an expanded suite of potential 1433 binding partners
Glial remodeling enhances short-term memory performance in Wistar rats
High-dimensional analysis of intestinal immune cells during helminth infection
Pan-cancer analysis of whole genomes
Patterns of somatic structural variation in human cancer genomes
The repertoire of mutational signatures in human cancer
How nurse practitioners spend their time in nursing facilities: revisited 20 years later
A mechanochemical model of transcriptional bursting
ATP13A2 deficiency disrupts lysosomal polyamine export
Asymmetry in kinematic generalization between visual and passive lead-in movements are consistent with a forward model in the sensorimotor system
Assisted reproduction mediated resurrection of a feline model for Chediak-Higashi syndrome caused by a large duplication in LYST
BIG-TREE: base-edited isogenic hPSC line generation using a transient reporter for editing enrichment
In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis
Signalling architectures can prevent cancer evolution
Gamma visual stimulation induces a neuroimmune signaling profile distinct from acute neuroinflammation
Tobacco smoking and somatic mutations in human bronchial epithelium
Zucchini consensus motifs determine the mechanism of pre-piRNA production
Tissue mechanics drives regeneration of a mucociliated epidermis on the surface of Xenopus embryonic aggregates
GPR108 is a highly conserved AAV entry factor
Blood contains circulating cell‐free respiratory competent mitochondria
Identification of lineage-specific transcription factors that prevent activation of hepatic stellate cells and promote fibrosis resolution
Tractions and stress fibers control cell shape and rearrangements in collective cell migration
NP03, a microdose lithium formulation, blunts early amyloid post-plaque neuropathology in McGill-R-Thy1-APP Alzheimer-like transgenic rats
A brief history of human disease genetics
Effects of the microalgae Chlamydomonas on gastrointestinal health
Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy
iPSC modeling of young-onset Parkinsons disease reveals a molecular signature of disease and novel therapeutic candidates
Long-gap peripheral nerve repair through sustained release of a neurotrophic factor in nonhuman primates
Hybrid erythrocyte liposomes: functionalized red blood cell membranes for molecule encapsulation
Cerebellar neurodynamics predict decision timing and outcome on the single-trial level
Enhancing hematopoiesis from murine embryonic stem cells through MLL1-induced activation of a Rac/Rho/integrin signaling axis
A proteomic atlas of senescence-associated secretomes for aging biomarker development
TBK1 is a synthetic lethal target in cancer with VHL loss
Ribonucleotide reductase inhibitors suppress SAMHD 1 ara‐ CTP ase activity enhancing cytarabine efficacy
Age-related alterations in inhibitory control investigated using the minimally delayed oculomotor response task
Aluminum and amyloid-β in familial Alzheimers disease
mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress
VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours
Effect of vitamin D3 supplementation on vascular and metabolic health of vitamin Ddeficient overweight and obese children: a randomized clinical trial
EasyPass: combating IoT delay with multiple access wireless side channels
Global, regional, and national sepsis incidence and mortality, 19902017: analysis for the Global Burden of Disease Study
89Zr-immuno-PET: toward a noninvasive clinical tool to measure target engagement of therapeutic antibodies in vivo
In vivo sequestration of innate small molecules to promote bone healing
A large size-selective DNA nanopore with sensing applications
Repression of phagocytosis by human CD33 is not conserved with mouse CD33
Mitochondrial DNA stress signalling protects the nuclear genome
Chemical functionality of multidomain peptide hydrogels governs early host immune response
Nicotinamide pathway-dependent Sirt1 activation restores calcium homeostasis to achieve neuroprotection in spinocerebellar ataxia type 7
Primary cilia signaling promotes axonal tract development and is disrupted in Joubert syndrome-related disorders models
A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus
Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice
Prospective longitudinal atrophy in Alzheimers disease correlates with the intensity and topography of baseline tau-PET
Prevention of tuberculosis in macaques after intravenous BCG immunization
Braiding topology and the energy landscape of chromosome organization proteins
The 111 study: a single-arm, phase 3 trial evaluating one cycle of bleomycin, etoposide, and cisplatin as adjuvant chemotherapy in high-risk, stage 1 nonseminomatous or combined germ cell tumours of the testis
Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a di-heptamer macromolecular assembly
Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway
Multiyear follow-up of AAV5-hFVIII-SQ gene therapy for Hemophilia A
Proteomic analyses of decellularized porcine ovaries identified new matrisome proteins and spatial differences across and within ovarian compartments
Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis
Cranial irradiation mediated spine loss is sex-specific and complement receptor-3 dependent in male mice
Relaxin reverses maladaptive remodeling of the aged heart through Wnt-signaling
Neural stem cell extracellular vesicles disrupt midline shift predictive outcomes in porcine ischemic stroke model
Polymeric sheet actuators with programmable bioinstructivity
Cancer statistics, 2020
Translational regulation of non-autonomous mitochondrial stress response promotes longevity
Outcomes of adult heart transplantation using hepatitis Cpositive donors
Extracellular matrix-based biomaterials and their influence upon cell behavior
BPA: have flawed analytical techniques compromised risk assessments?
External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomized controlled trial
Nongenic cancer-risk SNPs affect oncogenes, tumor-suppressor genes, and immune function
Molecular profiling of single neurons of known identity in two ganglia from the crab Cancer borealis
Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut
Carboxylated branched poly(β-amino ester) nanoparticles enable robust cytosolic protein delivery and CRISPR-Cas9 gene editing
NAIL-MS reveals the repair of 2-methylthiocytidine by AlkB in E. coli
Unified mechanism of local drivers in a percolation model of atrial fibrillation
Structure of the human metapneumovirus polymerase phosphoprotein complex
CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence
Distinct tumor microenvironments of lytic and blastic bone metastases in prostate cancer patients
Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor
Achieving spin-triplet exciton transfer between silicon and molecular acceptors for photon upconversion
Functional organization of motor networks in the lumbosacral spinal cord of non-human primates
Group A streptococcal S protein utilizes red blood cells as immune camouflage and is a critical determinant for immune evasion
Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection
Proliferating transitory T Cells with an effector-like transcriptional signature emerge from PD-1 stem-like CD8 T cells during chronic infection
MOWChIP-seq for low-input and multiplexed profiling of genome-wide histone modifications
Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state
Specific inhibition of the NLRP3 inflammasome as an anti-inflammatory strategy in Cystic Fibrosis
Effects of total sleep deprivation on procedural placekeeping: More than just lapses of attention
Peritumoral activation of the Hippo pathway effectors Yap and Taz suppresses liver cancer in mice
CRISPR/Cas13a‐powered electrochemical microfluidic biosensor for nucleic acid amplification‐free miRNA diagnostics
Oral ionic liquid for the treatment of diet-induced obesity
PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies
Fructose-1,6-bisphosphatase 2 inhibits sarcoma progression by restraining mitochondrial biogenesis
How many rare diseases are there?
A Tppp3 Pdgfra tendon stem cell population contributes to regeneration and reveals a shared role for PDGF signalling in regeneration and fibrosis
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
Nucleolar dynamics and interactions with nucleoplasm in living cells
Protective immunity against severe malaria in children is associated with a limited repertoire of antibodies to conserved PfEMP1 variants
Rab5-mediated endosome formation is regulated at the trans-Golgi network
P. aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling
Transcriptional regulatory model of fibrosis progression in the human lung
Topology, geometry, and mechanics of strongly stretched and twisted filaments: solenoids, plectonemes, and artificial muscle fibers
Positive and negative chemotaxis of enzyme-coated liposome motors
Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures
A functional link between nuclear RNA decay and transcriptional control mediated by the polycomb repressive complex 2
Metabolic modifier screen reveals secondary targets of protein kinase inhibitors within nucleotide metabolism
Generation of complex human organoid models including vascular networks by incorporation of mesodermal progenitor cells
Dopamine D2 receptor modulates Wnt expression and control of cell proliferation
Bioscaffold-induced brain tissue regeneration
Lipid signaling drives proteolytic rewiring of mitochondria by YME1L
Incorporation of biomarkers into risk assessment for allocation of antihypertensive medication according to the 2017 ACC/AHA high blood pressure guideline: a pooled cohort analysis
Metabolic effects of JAK1/2 inhibition in patients with myeloproliferative neoplasms
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35
Integrative transcriptomics reveals sexually dimorphic control of the cholinergic/neurokine interface in schizophrenia and bipolar disorder
CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumor growth
Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration
Combined electrostatic and air driven electrospinning for biomedical applications
Is running associated with a lower risk of all-cause, cardiovascular and cancer mortality, and is the more the better? A systematic review and meta-analysis
Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex
Transcriptional signature derived from murine tumor-associated macrophages correlates with poor outcome in breast cancer patients
Wearable sensors for estimation of Parkinsonian tremor severity during free body movements
Loading dependent structural model of polymeric micelles encapsulating curcumin by solid-state NMR spectroscopy
Dynorphin‐based release on demand gene therapy for drug‐resistant temporal lobe epilepsy
Dental epithelial stem cells as a source for mammary gland regeneration and milk producing cells in vivo
Non-enzymatic roles of human RAD51 at stalled replication forks
A mechanism for increased sensitivity of acute myeloid leukemia to mitotoxic drugs
Structure of the RSC complex bound to the nucleosome
RhoA controls axon extension independent of specification in the developing brain
Broadly protective human antibodies that target the active site of influenza virus neuraminidase
PilT and PilU are homohexameric ATPases that coordinate to retract type IVa pili
Search-and-replace genome editing without double-strand breaks or donor DNA
Association between cardiovascular health and cognitive performance: a twins study
Individualized recovery of gut microbial strains post antibiotics
Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm
Overall mortality after diagnosis of breast cancer in men vs women
Peptoid nanotubes: bioinspired peptoid nanotubes for targeted tumor cell imaging and chemo‐photodynamic therapy (small 43/2019)
Association of acquired and heritable factors with intergenerational differences in age at symptomatic onset of Alzheimer disease between offspring and parents with dementia
Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection
Regulation of lifespan by neural excitation and REST
Fusing randomized trials with big data: the key to self-learning health care systems?
Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation
Phenolic compounds from coffee by-products modulate adipogenesis-related inflammation, mitochondrial dysfunction, and insulin resistance in adipocytes, via insulin/PI3K/AKT signaling pathways
Patient-tailored, connectivity-based forecasts of spreading brain atrophy
Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity
TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision
Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimers disease
Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes
1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding
Global impact of somatic structural variation on the DNA methylome of human cancers
Analysis of old proteins unmasks dynamic gradient of cartilage turnover in human limbs
Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study
Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease
Cannabidiol counteracts the psychotropic side-effects of δ-9-tetrahydrocannabinol in the ventral hippocampus through bi-directional control of ERK1-2 phosphorylation
Amyloid-beta impairs TOM1-mediated IL-1R1 signaling
The use of biologics for the elbow: a critical analysis review
The role of biologic agents in the management of common shoulder pathologies: current state and future directions
Dietary sugars alter hepatic fatty acid oxidation via transcriptional and post-translational modifications of mitochondrial proteins
Global trends in antimicrobial resistance in animals in low- and middle-income countries
Structures of the rhodopsin-transducin complex: insights into G-protein activation
Ultralow-threshold, continuous-wave upconverting lasing from subwavelength plasmons
A triple drug combination targeting components of the nutrient-sensing network maximizes longevity
Preclinical performance of a pediatric mechanical circulatory support device: The PediaFlow ventricular assist device
Impact of the 2016 revision of US pediatric heart allocation policy on waitlist characteristics and outcomes
Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment
American Society for Bone and Mineral Research‐Orthopaedic Research Society Joint Task Force report on cell‐based therapies
Effects of high glucoseinduced lysyl oxidase propeptide on retinal endothelial cell survival
Fatty liver disease caused by high-alcohol-producing Klebsiella pneumoniae
Targeted delivery of CRISPR interference system against Fabp4 to white adipocytes ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance
Structural insight into eukaryotic sterol transport through Niemann-Pick type C proteins
Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery
Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma
Impact of the 2016 revision of US pediatric heart allocation policy on waitlist characteristics and outcomes
Fungal biofilm morphology impacts hypoxia fitness and disease progression
N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells
Monitoring the formation of amyloid oligomers using photoluminescence anisotropy
A neuroD1 AAV-based gene therapy for functional brain repair after ischemic injury through in vivo astrocyte-to-neuron conversion
A cell fitness selection model for neuronal survival during development
Machine learning analysis of DNA methylation profiles distinguishes primary lung squamous cell carcinomas from head and neck metastases
Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease
Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma
B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma
Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy
Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-Tfh cells
Induction of immunological tolerance to myelinogenic glial-restricted progenitor allografts
PSEN1ΔE9, APPswe, and APOE4 confer disparate phenotypes in human iPSC-derived microglia
Interrogating Parkinson's disease associated redox targets: potential application of CRISPR editing
Complex oscillatory waves emerging from cortical organoids model early human brain network development
Electronic skin to feel pain: detecting prick and hot pain sensations
Comparable rates of integrated myofibrillar protein synthesis between endurance-trained master athletes and untrained older individuals
Notch coordinates periodontal ligament maturation through regulating Lamin A.
Transplantation of kidneys from hepatitis Cinfected donors to hepatitis Cnegative recipients: Single center experience
Position B57 of I-A controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset
Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy
OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo
A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research
A cell-penetrating scorpion toxin enables mode-specific modulation of TRPA1 and pain
MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers
MiR322 mediates cardioprotection against ischemia/reperfusion injury via FBXW7/notch pathway
Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis
Mechanical stabilization of the glandular acinus by linker of nucleoskeleton and cytoskeleton complex
Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction
A mechanism for statin-induced susceptibility to myopathy
Nab-paclitaxel: a new standard of care in neoadjuvant therapy of high-risk early breast cancer?
Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study
Structure, function, and ion-binding properties of a K+ channel stabilized in the 2,4-ionbound configuration
Organ-on-e-chip: Three-dimensional self-rolled biosensor array for electrical interrogations of human electrogenic spheroids
Optimization of silicone 3d printing with hierarchical machine learning
Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy
Pro-survival lipid sphingosine-1-phosphate metabolically programs T cells to limit anti-tumor activity
Abemaciclib is effective against pancreatic cancer cells and synergizes with HuR and YAP1 inhibition
MEK inhibition modulates cytokine response to mediate therapeutic efficacy in lung cancer
Remote post-ischemic conditioning promotes stroke recovery by shifting circulating monocytes to CCR2+ pro-inflammatory subset
Energy‐mediated machinery drives cellular mechanical allostasis
Genetic liability to insomnia and cardiovascular disease risk
Interaction of α carboxyl terminus 1 peptide with the connexin 43 carboxyl terminus preserves left ventricular function after ischemia‐reperfusion injury
Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve
Downgrading of regulation in regenerative medicine
Adenosine kinase inhibition augments conducted vasodilation and prevents left ventricle diastolic dysfunction in heart failure with preserved ejection fraction
Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer
A robotic neck brace to characterize head‐neck motion and muscle electromyography in subjects with amyotrophic lateral sclerosis
Molecular structure of an N-terminal phosphorylated β-amyloid fibril
A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier
Neuronal BC RNA transport impairments caused by systemic lupus erythematosus autoantibodies
In vivo restoration of myocardial conduction with carbon nanotube fibers
A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea
Wireless optofluidic brain probes for chronic neuropharmacology and photostimulation
Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimers disease
Development of a clinically relevant chemoresistant mantle cell lymphoma cell culture model
Long-term host immune response trajectories among hospitalized patients with sepsis
Generation of human fatty livers using custom-engineered induced pluripotent stem cells with modifiable SIRT1 metabolism
High-dose spironolactone when patients with acute decompensated heart failure are resistant to loop diuretics: a pilot study
Metal oxide semiconductor nanomembranebased soft unnoticeable multifunctional electronics for wearable human-machine interfaces
Modeling steatohepatitis in humans with pluripotent stem cell-derived organoids
Meta-weighted gaussian process experts for personalized forecasting of AD cognitive changes
An artificial intelligence-enabled ECG algorithm for the identification of patients with atrial fibrillation during sinus rhythm: a retrospective analysis of outcome prediction
Structural redundancy in supracellular actomyosin networks enables robust tissue folding
Repressive gene regulation synchronizes development with cellular metabolism
Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells
Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors
3D bioprinting of collagen to rebuild components of the human heart
The AMPK-related kinases SIK1 and SIK3 mediate key tumor suppressive effects of LKB1 in NSCLC
RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats
Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis
Biomimetic sensory feedback through peripheral nerve stimulation improves dexterous use of a bionic hand
Modular and tunable biological feedback control using a de novo protein switch
De novo design of bioactive protein switches
AEBP1 expression increases with severity of fibrosis in NASH and is regulated by glucose, palmitate, and miR-372-3p
Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2
Adenylyl cyclase 5generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia
Predicting bacterial infection outcomes using single cell RNA-sequencing analysis of human immune cells
Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease
A case report of clonal EBV-like memory CD4 T cell activation in fatal checkpoint inhibitor-induced encephalitis
Targeting seizure-induced neurogenesis in a clinically relevant time-period leads to transient but not persistent seizure reduction
Potential roles of gut microbiome and metabolites in modulating ALS in mice
Optogenomic interfaces: bridging biological networks with the electronic digital world
Persistent gamma spiking in SI nonsensory fast spiking cells predicts perceptual success
Damage sensor role of UV-DDB during base excision repair
Association between state-mandated protocolized sepsis care and in-hospital mortality among adults with sepsis
Adult living donor versus deceased donor liver transplant (LDLT Versus DDLT) at a single center. Time to change our paradigm for liver transplant
Using a continuum model to decipher the mechanics of embryonic tissue spreading from time-lapse image sequences: An approximate Bayesian computation approach
Enhanced CART cell activity against solid tumors by vaccine boosting through the chimeric receptor
Targeting IDH1 as a prosenescent therapy in high-grade serous ovarian cancer
Forward genetic screen for Caenorhabditis elegans mutants with a shortened locomotor healthspan
Biocide resistance and transmission of Clostridium difficile spores spiked onto clinical surfaces from an American healthcare facility
Electrocardiomatrix facilitates accurate detection of atrial fibrillation in stroke patients
Protein interaction networks revealed by proteome coevolution
Sheath-run artificial muscles
Structure and mechanism of pyrimidinepyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotide excision repair complex
DNA translocation mechanism of the MCM complex and implications for replication initiation
Nerve injury drives a heightened state of vigilance and neuropathic sensitization in Drosophila
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis
Single-cell analysis reveals T cell infiltration in old neurogenic niches
Designer artificial membrane binding proteins to direct stem cells to the myocardium
Inhibition of HER2-positive breast cancer growth by blocking the HER2 signaling pathway with HER2-glycan-imprinted nanoparticles
Crystal structure of the mitochondrial protein mitoNEET bound to a benze-sulfonide ligand
An ultrafast system for signaling mechanical pain in human skin
Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7
National and state estimates of lost earnings from cancer deaths in the United States
Self-organized synchronous calcium transients in a cultured human neural network derived from cerebral organoids
Sequential LASER ART and CRISPR treatments eliminate HIV-1 in a subset of infected humanized mice
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis
Single-cell analysis reveals T cell infiltration in old neurogenic niches
Designer artificial membrane binding proteins to direct stem cells to the myocardium
Inhibition of HER2-positive breast cancer growth by blocking the HER2 signaling pathway with HER2-glycan-imprinted nanoparticles
Crystal structure of the mitochondrial protein mitoNEET bound to a benze-sulfonide ligand
An ultrafast system for signaling mechanical pain in human skin
Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7
National and state estimates of lost earnings from cancer deaths in the United States
Self-organized synchronous calcium transients in a cultured human neural network derived from cerebral organoids
Sequential LASER ART and CRISPR treatments eliminate HIV-1 in a subset of infected humanized mice
Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1
BACH1 stabilization by antioxidants stimulates lung cancer metastasis
Human intestinal enteroids with inducible neurogenin-3 expression as a novel model of gut hormone secretion
Structure of the Cdc48 segregase in the act of unfolding an authentic substrate
LC3-associated endocytosis facilitates β-amyloid clearance and mitigates neurodegeneration in murine Alzheimers disease
The x-linked DDX3X RNA helicase dictates translation reprogramming and metastasis in melanoma
Infection as a stroke trigger
SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility
Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells
Noninvasive neuroimaging enhances continuous neural tracking for robotic device control
Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy
De novo lung biofabrication: clinical need, construction methods, and design strategy
Patterns of opioid administration among opioid-naive inpatients and associations with postdischarge opioid use: a cohort study
Vitamin K status and mobility limitation and disability in older adults: the health, aging, and body composition study
Comparative virtual biopsies of normal skin and skin lesions using vibrational optical coherence tomography
Cartilage binding antibodies induce pain through immune complex mediated activation of neurons
Improved outcomes after autologous hematopoietic cell transplantation for light chain amyloidosis: a Center for International Blood and Marrow Transplant Research study
Viral capsid trafficking along treadmilling tubulin filaments in bacteria
Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids
Long-duration hippocampal sharp wave ripples improve memory
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
Identifying brain tumors by differential mobility spectrometry analysis of diathermy smoke
Stabilization of the cardiac sarcolemma by sarcospan rescues DMD-associated cardiomyopathy
Preimplant phosphodiesterase-5 inhibitor use is associated with higher rates of severe early right heart failure after left ventricular assist device implantation: an INTERMACS analysis.
Spatiotemporal structure of cell fate decisions in murine neural crest
Mitochondrial dysfunction causes Ca2 overload and ECM degradationmediated muscle damage in C. elegans
Single-cell transcriptomics unveils gene regulatory network plasticity
Pre-existing commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumor cell dissemination in hormone receptor-positive breast cancer
Cooperation between constitutive and inducible chemokines enables T cell engraftment and immune attack in solid tumors
Tau binding protein CAPON induces tau aggregation and neurodegeneration
Age mosaicism across multiple scales in adult tissues
Cell-based therapy restores olfactory function in an inducible model of hyposmia
Tissue-engineering the intestine: the trials before the trials
Establishment of porcine and human expanded potential stem cells
New neural activity patterns emerge with long-term learning
Fatty acid transport protein 2 reprograms neutrophils in cancer
Association of net ultrafiltration rate with mortality among critically ill adults with AKI receiving continuous venovenous hemodiafiltration
Propagation and selectivity of axonal loss in Leber hereditary optic neuropathy
Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation
Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment
The cell-wide web coordinates cellular processes by directing site-specific Ca2 flux across cytoplasmic nanocourses
Translation affects mRNA stability in a codon-dependent manner in human cells
A randomized trial evaluating bioimpedance spectroscopy versus tape measurement for the prevention of lymphedema following treatment for breast cancer: interim analysis
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations
The viral protein corona directs viral pathogenesis and amyloid aggregation
Artificially enhancing and suppressing hippocampus-mediated memories
Solution processable liquid metal nanodroplets by surface-initiated atom transfer radical polymerization
Reward-driven changes in striatal pathway competition shape evidence evaluation in decision-making
Electric field based dressing disrupts mixed-species bacterial biofilm infection and restores functional wound healing
Egg consumption, cholesterol intake, and risk of incident stroke in men: the Kuopio Ischaemic Heart Disease Risk Factor Study
BRD4 regulates metastatic potential of castration-resistant prostate cancer through AHNAK
Epigenetic dysregulation of enhancers in neurons is associated with Alzheimers disease pathology and cognitive symptoms
Light entrains diurnal changes in insulin sensitivity of skeletal muscle via ventromedial hypothalamic neurons
Bioactive site-specifically modified proteins for 4D patterning of gel biomaterials
Charting cellular identity during human in vitro β-cell differentiation
Insufficient sleep is associated with a pro‐atherogenic circulating microRNA signature
Coordinated conformational processing of the tumor suppressor protein p53 by the Hsp70 and Hsp90 chaperone machineries
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway
Treatment of volumetric muscle loss in mice using nanofibrillar scaffolds enhances vascular organization and integration
Early neuromuscular blockade in the acute respiratory distress syndrome
Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis
Targeted and persistent 8-oxoguanine base damage at telomeres promotes telomere loss and crisis
Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells
Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma
Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibitionresistant triple-negative breast cancer cells
Prospective comprehensive genomic profiling of primary and metastatic prostate tumors
Non-self Mutation: Double-stranded RNA elicits antiviral pathogenic response in a Drosophila model of expanded CAG repeat neurodegenerative diseases
Aβ oligomer elimination restores cognition in transgenic Alzheimers mice with full-blown pathology
Osteoblasts are educated by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment
Rare protein-truncating variants in APOB, lower LDL-C, and protection against coronary heart disease
A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip
Rapid invariant encoding of scene layout in human OPA
A prospective, single-arm, multicenter trial of catheter-directed mechanical thrombectomy for intermediate-risk acute pulmonary embolism--the FLARE study
A high-throughput platform to identify small-molecule inhibitors of CRISPR-Cas9
Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation
Neural population control via deep image synthesis
Human salivary amylase gene copy number impacts oral and gut microbiomes
Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor
Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease
Inhibition of MYC by the SMARCB1 tumor suppressor
Chromatin three-dimensional interactions mediate genetic effects on gene expression
Direct induction of the three pre-implantation blastocyst cell types from fibroblasts
A compact synthetic pathway rewires cancer signaling to therapeutic effector release
Pericyte transplantation improves skeletal muscle recovery following hindlimb immobilization
Neural control of body-plan axis in regenerating planaria
A niche-dependent myeloid transcriptome signature defines dormant myeloma cells
Lung cancer in never-smokers: a hidden disease
TET enzymes augment AID expression via 5hmC modifications 1 at the Aicda superenhancer
Cross-sectional study of HPV testing in self-sampled urine and comparison with matched vaginal and cervical samples in women attending colposcopy for the management of abnormal cervical screening
A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Why does Clostridium difficile infection recur?
Catalytic antimicrobial robots for biofilm eradication
An integrated microfluidic flow-focusing platform for on-chip fabrication and filtration of cell-laden microgels
Collaboration and competition between active sheets for self-propelled particles
Cost-effectiveness of the US Food and Drug Administration added sugar labeling policy for improving diet and health
TRIM9-mediated resolution of neuroinflammation confers neuroprotection upon ischemic stroke in mice
Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and oncogenic properties
A single-cell atlas of the tumor and immune ecosystem of human breast cancer
CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML
A novel, widespread qacA allele results in reduced chlorhexidine susceptibility in Staphylococcus epidermidis
Clinical credence SGLT2 inhibitors, diabetes, and chronic kidney disease
Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM
Working memory revived in older adults by synchronizing rhythmic brain circuits
3D printing of personalized thick and perfusable cardiac patches and hearts
Association of closed-loop brain stimulation neurophysiological features with seizure control among patients with focal epilepsy
Quiescence modulates stem cell maintenance and regenerative capacity in the aging brain
Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination
Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond
Diagnostic and prognostic potential of AKR1B10 in human hepatocellular carcinoma
The antiangiogenic activity of naturally occurring and synthetic homoisoflavonoids from the Hyacinthaceae (sensu APGII)
Immunization with components of the viral fusion apparatus elicits antibodies that neutralize Epstein-Barr virus in B cells and epithelial cells
Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species
Outcomes after proton therapy for treatment of pediatric high-risk neuroblastoma
Genetic testing and results in a population-based cohort of breast cancer patients and ovarian cancer patients
cisTopic: cis-regulatory topic modeling on single-cell ATAC-seq data
Patient behaviors and characteristics related to weight regain after Roux-en-Y gastric bypass: a multicenter prospective cohort study
The emerging relationship between regenerative medicine and physical therapeutics
GRASP55 and UPR control interleukin-1β aggregation and secretion
MYC recruits SPT5 to RNA polymerase II to promote processive transcription elongation
Association of in vitro fertilization with childhood cancer in the United States
Skin-inspired, open mesh electrochemical sensors for lactate and oxygen monitoring
Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice
Ultrasensitive hyperspectral imaging and biodetection enabled by dielectric metasurfaces
Tendinosis develops from age‐ and oxygen tension‐dependent modulation of Rac1 activity
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer
Prediction of premature all-cause mortality: A prospective general population cohort study comparing machine-learning and standard epidemiological approaches
A common embryonic origin of stem cells drives developmental and adult neurogenesis
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion
p190RhoGAP filters competing signals to resolve axon guidance conflicts
Ptpn21 controls hematopoietic stem cell homeostasis and biomechanics
The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis
Stimuli-responsive injectable cellulose thixogel for cell encapsulation
Cell-free gene-regulatory network engineering with synthetic transcription factors
Proposed percutaneous aortic valve prosthesis made of cryogel
L-sepiapterin restores SLE serum-induced markers of endothelial function in endothelial cells
Genome-wide association meta-analysis of functional outcome after ischemic stroke
Targeting senescent cells alleviates obesity‐induced metabolic dysfunction
High-fructose corn syrup enhances intestinal tumor growth in mice
Total pancreatectomy with islet autologous transplantation: the cure for chronic pancreatitis?
Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest
Novel insights from uncultivated genomes of the global human gut microbiome
Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells
Effects of icosapent ethyl on total ischemic events: from REDUCE-IT
A nuclear phosphoinositide kinase complex regulates p53
Role of human ventromedial prefrontal cortex in learning and recall of enhanced extinction
GARP dampens cancer immunity by sustaining function and accumulation of regulatory T cells in the colon
Biomaterials-aided mandibular reconstruction using in vivo bioreactors
Infection drives long-term meningeal engraftment by inflammatory monocytes that impair central nervous system immunity
Using a deep learning algorithm and integrated gradients explanation to assist grading for diabetic retinopathy
Restoration of high-sensitivity and adapting vision with a cone opsin
Intrahepatic fibrin(ogen) deposition drives liver regeneration after partial hepatectomy in mice and humans
HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms
PARP inhibition enhances tumor cellintrinsic immunity in ERCC1-deficient nonsmall cell lung cancer
Associations between vascular risk factors and brain MRI indices in UK Biobank
Retinal microvascular and neurodegenerative changes in Alzheimers disease and mild cognitive impairment compared with control participants
68Ga-FAPI PET/CT: Biodistribution and Preliminary Dosimetry Estimate of 2 DOTA-Containing FAP-Targeting Agents in Patients with Various Cancers
Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome
Successful genetic transfection of the colonic protistan parasite blastocystis for reliable expression of ectopic genes
Interactions between a pathogenic Blastocystis subtype and gut microbiota: in vitro and in vivo studies
Label-free Raman spectroscopy reveals signatures of radiation resistance in the tumor microenvironment
Association of muscular strength and incidence of type 2 diabetes
Fabrication of 3D-nanofibrous fibrinogen scaffolds using salt-induced self-assembly
ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
Foxg1 antagonizes neocortical stem cell progression to astrogenesis
Impact of sarcopenia in patients with advanced nonsmall cell lung cancer treated with PD-1 inhibitors: A preliminary retrospective study
Tapered InP nanowire arrays for efficient broadband high-speed single-photon detection
Fibroblasts activation and abnormal extracellular matrix remodelling as common hallmarks in three cancer-prone genodermatoses
Identification of PKD1L1 gene variants in children with the biliary atresia splenic malformation syndrome
Tubuloids derived from human adult kidney and urine for personalized disease modeling
Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers
RNA binding antagonizes neurotoxic phase transitions of TDP-43
Real-time targeted genome profile analysis of pancreatic ductal adenocarcinomas identifies genetic alterations that might be targeted with existing drugs or used as biomarkers
The Society of Thoracic Surgeons Intermacs database annual report: Evolving indications, outcomes, and scientific partnerships
Transplanting hepatitis C virus‐infected hearts into uninfected recipients: A single‐arm trial
The ATP-binding cassette gene ABCF1 functions as an E2 ubiquitin-conjugating enzyme controlling macrophage polarization to dampen lethal septic shock
Structure of Calcarisporiella thermophila Hsp104 disaggregase that antagonizes diverse proteotoxic misfolding events
H4K20me0 recognition by BRCA1BARD1 directs homologous recombination to sister chromatids
Bisulfite-free direct detection of 5-methylcytosine and 5-hydroxymethylcytosine at base resolution
Intracellular bacteria engage a STINGTBK1MVB12b pathway to enable paracrine cGASSTING signalling
Isolation of circulating tumor cells in non-small-cell-lung-cancer patients using a multi-flow microfluidic channel
Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2
Cognitive and physical activity and dementia
A neuron-optimized CRISPR/dCas9 activation system for robust and specific gene regulation
Young bone marrow transplantation preserves learning and memory in old mice
Concentric organization of A- and B-type lamins predicts their distinct roles in the spatial organization and stability of the nuclear lamina
The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction
Neurons with complex karyotypes are rare in aged human neocortex
Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle
Avelumab plus Axitinib versus Sunitinib for advanced renal-cell carcinoma
Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis
Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy
Fibroblasts and alectinib switch the evolutionary games played by non-small cell lung cancer
Gene-by-sex interactions in mitochondrial functions and cardio-metabolic traits
A novel combinatorial technique for simultaneous quantification of oxygen radicals and aggregation reveals unexpected redox patterns in the activation of platelets by different physiopathological stimuli
Diabetes relief in mice by glucose-sensing insulin-secreting human alpha-cells
Intracortical neural stimulation with untethered, ultrasmall carbon fiber electrodes mediated by the photoelectric effect
Obstructive sleep apnea and inflammation: proof of concept based on two illustrative cytokines
eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes
Measles vector as a multiple genes delivery platform facilitating iPSC reprogramming
Hearing impairment and cognitive decline in older, community-dwelling adults
Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration
Species-specific maturation profiles of human, chimpanzee and bonobo neural cells
Dynamically stiffened matrix promotes malignant transformation of mammary epithelial cells via collective mechanical signaling
Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
Estrogen improves insulin sensitivity and suppresses gluconeogenesis via the transcription factor Foxo1
CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex
A human gut bacterial genome and culture collection for improved metagenomic analyses
SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer
CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary
Predictors of symptomatic kidney stone recurrence after the first and subsequent episodes
Codon stabilization coefficient as a metric to gain insights into mRNA stability and codon bias and their relationships with translation
HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses
Physical activity of UK adults with chronic disease: cross-sectional analysis of accelerometer-measured physical activity in 96,706 UK Biobank participants
Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation
Wild-type p53 promotes cancer metabolic switch by inducing PUMA-dependent suppression of oxidative phosphorylation
Energy harvesting: flexible porous piezoelectric cantilever on a pacemaker lead for compact energy harvesting
Inhibiting glutamine-dependent mTORC1 activation ameliorates liver cancers driven by β-catenin mutations
Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study
NFIL3 mutations alter immune homeostasis and sensitise for arthritis pathology
Astrocytes regulate the development and maturation of retinal ganglion cells derived from human pluripotent stem cells
Skeletal muscles do not undergo apoptosis during either atrophy or programmed cell death-revisiting the myonuclear domain hypothesis
The endoplasmic reticulum chaperone glucose-regulated protein 94 is essential for proinsulin handling
Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice
Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging
Allogeneic ex vivo expanded corneal epithelial stem cell transplantation: a randomized controlled clinical trial
EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains
Cholecystokinin and Alzheimers disease: a biomarker of metabolic function, neural integrity, and cognitive performance
Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration
COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease
Functional synaptic architecture of callosal inputs in mouse primary visual cortex
Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury
Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data
Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated dont-eat-me signal
Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice
Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's Disease
Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones
High Rac1 activity is functionally translated into cytosolic structures with unique nanoscale cytoskeletal architecture
Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer
Cell number in mesenchymal stem cell aggregates dictates cell stiffness and chondrogenesis
Disruption of coronin 1 signaling in T Cells promotes allograft tolerance while maintaining anti-pathogen immunity
Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila
3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice
An interferon-driven oxysterol-based defense against tumor-derived extracellular vesicles
Genetic liver-specific AMPK activation protects against diet-induced obesity and NAFLD
Synapse-selective control of cortical maturation and plasticity by Parvalbumin-autonomous action of SynCAM 1
Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon α-cells
WISP-1 drives bone formation at the expense of fat formation in human perivascular stem cells
Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study
Lactosylceramide synthase β-1,4-GalT-V: A novel target for the diagnosis and therapy of human colorectal cancer
Maternal choline supplementation ameliorates Alzheimers disease pathology by reducing brain homocysteine levels across multiple generations
Antigen-specific TCR signatures of cytomegalovirus infection
Arginine citrullination at the C-terminal domain controls RNA polymerase II transcription
A collicular visual cortex: Neocortical space for an ancient midbrain visual structure
Inhaled nanoformulated mRNA polyplexes for protein production in lung epithelium
Biologically inspired, cell‐selective release of aptamer‐trapped growth factors by traction forces
Calcium activation of cortical neurons by continuous electrical stimulation: Frequency dependence, temporal fidelity, and activation density
Designing self-propelled, chemically active sheets: Wrappers, flappers, and creepers
Identification of genes required for eye development by high-throughput screening of mouse knockouts
Disruption of the interaction of RAS with PI 3-kinase induces regression of EGFR-mutant-driven lung cancer
Harnessing genetic complexity to enhance translatability of Alzheimers disease mouse models: a path toward precision medicine
A novel alkaliphilic streptomyces inhibits ESKAPE pathogens
Identifying cis elements for spatiotemporal control of mammalian DNA replication
Targeted muscle reinnervation technique in below-knee amputation
A novel form of JARID2 is required for differentiation in lineage‐committed cells
Parity and risk of maternal cardiovascular disease: A doseresponse meta-analysis of cohort studies
Effects of a hydrophilic/hydrophobic interface on amyloid-β peptides studied by molecular dynamics simulations and NMR experiments
Effective wound healing enabled by discrete alternative electric fields from wearable nanogenerators
Mitochondria modulate programmed neuritic retraction
Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice
Integrative functional genomic analysis of human brain development and neuropsychiatric risks
Geographic disparities in lung transplant rates
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology
Portraits of communication in neuronal networks
Tryptophan 32 mediates SOD1 toxicity in a in vivo motor neuron model of ALS and is a promising target for small molecule therapeutics
TAC-seq: targeted DNA and RNA sequencing for precise biomarker molecule counting
Commensals suppress intestinal epithelial cell retinoic acid synthesis to regulate interleukin-22 activity and prevent microbial dysbiosis
A host-produced quorum-sensing autoinducer controls a phage lysis-lysogeny decision
Identifying the pathways required for coping behaviours associated with sustained pain
HIPPO signaling resolves embryonic cell fate conflicts during establishment of pluripotency in vivo
Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation
Quantifying single-cell secretion in real time using resonant hyperspectral imaging
Importin α5 regulates anxiety through MeCP2 and Sphingosine Kinase 1
Jamming of deformable polygons
Relationships between indicators of cardiovascular disease and intensity of oil and natural gas activity in northeastern Colorado
Multivariate computational analysis of gamma delta T cell inhibitory receptor signatures reveals the divergence of healthy and ART-suppressed HIV aging
Tau monomer encodes strains
Dual inhibition of the lactate transporters MCT1 and MCT4 is synthetic lethal with metformin due to NAD depletion in cancer cells
Livebirth after uterus transplantation from a deceased donor in a recipient with uterine infertility
Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat
Mycoplasma promotes malignant transformation in vivo, and its DnaK, a bacterial chaperon protein, has broad oncogenic properties
Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis
Active wrinkles to drive self-cleaning: A strategy for anti-thrombotic surfaces for vascular grafts
Topography-driven surface renewal
Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy
Assembly of a pan-genome from deep sequencing of 910 humans of African descent
Prion seeds distribute throughout the eyes of sporadic Creutzfeldt-Jakob disease patients
Injectable macroporous hydrogel formed by enzymatic cross-linking of gelatin microgels
Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery
Large-scale preparation of extracellular vesicles enriched with specific microRNA
Alginate-graphene oxide hydrogels with enhanced ionic tunability and chemomechanical stability for light-directed 3D printing
Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis
The fibrinolytic factor tPA drives LRP1-mediated melanoma growth and metastasis
Convective forces increase CXCR4-dependent glioblastoma cell invasion in GL261 murine model
Genetic analysis reveals AMPK is required to support tumor growth in murine kras-dependent lung cancer models
DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury
Dissociation between urate and blood pressure in mice and in people with early Parkinson's disease
Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium
LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages
Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion
Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival
Inhibition of amino acid metabolism selectively targets human leukemia stem cells
Shape selective bifacial recognition of double helical DNA
Organophosphate exposures during pregnancy and child neurodevelopment: Recommendations for essential policy reforms
Association of obesity subtypes in the longitudinal assessment of bariatric surgery study and 3‐year postoperative weight change
Statins attenuate outgrowth of breast cancer metastases
Magnetocardiography on an isolated animal heart with a room-temperature optically pumped magnetometer
Mutational landscape of secondary glioblastoma guides MET-targeted trial in brain tumor
Variation in TMEM106B in chronic traumatic encephalopathy
A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy
Antifibrotic synergy between phosphodiesterase type 5 inhibitors and selective oestrogen receptor modulators in Peyronie's Disease models
Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a
Evaluating the evidence on sitting, smoking, and health: is sitting really the new smoking?
A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice
Detailed visual cortical responses generated by retinal sheet transplants in rats with severe retinal degeneration
The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care
Wireless resonant circuits for the minimally invasive sensing of biophysical processes in magnetic resonance imaging
A histone acetylome-wide association study of Alzheimers disease identifies disease-associated H3K27ac differences in the entorhinal cortex
Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon α-cells
MUC5B promoter variant and rheumatoid arthritis with interstitial lung disease
Antiphospholipid antibodies in patients with myocardial infarction
Gut microbiota in the first 2 years of life and the association with body mass index at age 12 in a Norwegian birth cohort
BacCapSeq: a platform for diagnosis and characterization of bacterial infections
A microfabricated nerve-on-a-chip platform for rapid assessment of neural conduction in explanted peripheral nerve fibers
Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis
Programmed assembly of synthetic protocells into thermoresponsive prototissues
Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration
Colonic epithelial miR-31 associates with the development of Crohns phenotypes
NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients
The lineage-defining transcription factors SOX2 and NKX2-1 determine lung cancer cell fate and shape the tumor immune microenvironment
Reservoir computing with a single delay-coupled non-linear mechanical oscillator
Small-molecule-based regulation of RNA-delivered circuits in mammalian cells
Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment
Mammographic breast density assessment using deep learning: clinical implementation
ERBB2 signaling drives supporting cell proliferation in vitro and apparent supernumerary hair cell formation in vivo in the neonatal mouse cochlea
Comparison of the performance of common measures of weight regain after bariatric surgery for association with clinical outcomes
Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis
Modeling and prediction of clinical symptom trajectories in Alzheimers disease using longitudinal data
Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage
Complement component C3 is highly expressed in human pancreatic islets and prevents β cell death via ATG16L1 interaction and autophagy regulation
Conformational dynamics of the ABC transporter McjD seen by single‐molecule FRET
Genome-wide identification of structure-forming repeats as principal sites of fork collapse upon ATR inhibition
Electric fieldinduced release and measurement liquid biopsy for noninvasive early lung cancer assessment
ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis
Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase
Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids
Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program
Lifetime risk of common neurological diseases in the elderly population
The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20
Consumption of red and processed meat and breast cancer incidence: a systematic review and meta-analysis of prospective studies
Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas
Adult spinal motoneurons change their neurotransmitter phenotype to control locomotion
NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
Combination therapy with anti-HIV-1 antibodies maintains viral suppression
Fisetin is a senotherapeutic that extends health and lifespan
Biofabrication of autologous human hepatocytes for transplantation: how do we get there?
Preclinical performance of a pediatric mechanical circulatory support device: The PediaFlow ventricular assist device
Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells
An inhibitor of GSK3B and HDACs kills pancreatic cancer cells and slows pancreatic tumor growth and metastasis in mice
Brain endothelial erythrophagocytosis and hemoglobin transmigration across brain endothelium: implications for pathogenesis of cerebral microbleeds
MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons
Active wetting of epithelial tissues
Aging suppresses skin-derived circulating SDF1 to promote full-thickness tissue regeneration
Structure of the human epithelial sodium channel by cryo-electron microscopy
Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells
Changing dynamics of the drug overdose epidemic in the United States from 1979 through 2016
Functional classification of long non-coding RNAs by k-mer content
Serum biomarker signature-based liquid biopsy for diagnosis of early-stage pancreatic cancer
Genome-edited skin epidermal stem cells protect mice from cocaine-seeking behaviour and cocaine overdose
Membrane-induced hydroelastic migration of a particle surfing its own wave
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature
MicroRNA-141-3p negatively modulates SDF-1 expression in age dependent pathophysiology of human and murine bone marrow stromal cells
A high throughput screen for next-generation leads targeting malaria parasite transmission
Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate
Disease-associated short tandem repeats co-localize with chromatin domain boundaries
Experimental evaluation of the importance of colonization history in early-life gut microbiota assembly
Biodegradation of ECM hydrogel promotes endogenous brain tissue restoration in a rat model of stroke
Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy
Large-scale plasma lipidomic profiling identifies lipids that predict cardiovascular events in secondary prevention
Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration
Susceptible period for cardiovascular complications in patients recovering from sepsis
COMRADES determines in vivo RNA structures and interactions
Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology
Mood variations decoded from multi-site intracranial human brain activity
A fluid-to-solid jamming transition underlies vertebrate body axis elongation
In vivo reprogramming of wound-resident cells generates skin epithelial tissue
Direct generation of human cortical organoids from primary cells
Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway
RandomiSed clinical trial assessing Use of an anti-inflammatoRy aGent in attenUating peri-operatiVe inflAmmatioN in non-meTastatic colon cancer the S.U.R.G.U.V.A.N.T. trial
SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix
Epistatic control of intrinsic resistance by virulence genes in Listeria
Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis
Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction
Visual rehabilitation training alters attentional networks in hemianopia: An fMRI study
Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy
Time-restricted feeding prevents obesity and metabolic syndrome in mice lacking a circadian clock
Minimizing context dependency of gene networks using artificial cells
Discovery of novel cell surface markers for purification of embryonic dopamine progenitors for transplantation in Parkinsons disease animal models
Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes
SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling
Small molecules co-targeting CKIα and the transcriptional kinases CDK7/9 control AML in preclinical models
Digitally tunable microfluidic bioprinting of multilayered cannular tissues
County-level air quality and the prevalence of diagnosed chronic kidney disease in the US Medicare population
The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space
Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort
Intestinal metabolism and bioaccumulation of sucralose in adipose tissue in the rat
Telomere shortening is a hallmark of genetic cardiomyopathies
Association of variants in BAG3 with cardiomyopathy outcomes in African American individuals
Lack of Sprouty 1 and 2 enhances survival of effector CD8 T cells and yields more protective memory cells
Circulating tumor DNA measurements as early outcome predictors in diffuse large B-cell lymphoma
A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT)
Correlation between polar surface area and bioferroelectricity in DNA and RNA nucleobases
Electrostatic lock in the transport cycle of the multidrug resistance transporter EmrE
Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector
Progressive massive fibrosis resurgence identified in U.S. coal miners filing for black lung benefits, 19702016
Integrated phosphorescence-based photonic biosensor (iPOB) for monitoring oxygen levels in 3D cell culture systems
Huntingtin aggregation impairs autophagy, leading to Argonaute-2 accumulation and global microRNA dysregulation
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells
KIM-1 as a blood-based marker for early detection of kidney cancer: a prospective nested case-control study
Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors
Dysregulation in actin cytoskeletal organization drives increased stiffness and migratory persistence in polyploidal giant cancer cells
Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis
Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression
Photochemical 'in-air' combinatorial discovery of antimicrobial copolymers
Wireless control of cellular function by activation of a novel protein responsive to electromagnetic fields
Dysregulation of neuronal iron homeostasis as an alternative unifying effect of mutations causing familial Alzheimers disease
Multisensory bionic limb to achieve prosthesis embodiment and reduce distorted phantom limb perceptions
The environmental sensor AHR protects from inflammatory damage by maintaining intestinal stem cell homeostasis and barrier integrity
Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders
Effect of platelet-rich plasma on chondrogenic differentiation of adipose- and bone marrow-derived mesenchymal stem cells
Stretchable, implantable, nanostructured flow-diverter system for quantification of intra-aneurysmal hemodynamics
Impact of edible cricket consumption on gut microbiota in healthy adults, a double-blind, randomized crossover trial
Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion
Optical imaging of metabolic dynamics in animals
Evaluation of a novel rule-out myocardial infarction protocol incorporating high-sensitivity troponin T in a US hospital
Orthogonal self-assembly of an organoplatinum(II) metallacycle and cucurbit[8]uril that delivers curcumin to cancer cells
18F-fluoroestradiol tumor uptake is heterogeneous and influenced by site of metastasis in breast cancer patients
Hematopoietic cell-derived RELMα regulates hookworm immunity through effects on macrophages
Prioritizing the needs of children in a changing climate
Kinetic basis for DNA target specificity of CRISPR-Cas12a
Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for β cell recovery
Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift
Combining H-FABP and GFAP increases the capacity to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
Kidney-targeted inhibition of protein kinase C-α ameliorates nephrotoxic nephritis with restoration of mitochondrial dysfunction
A reliable murine model of bone metastasis by injecting cancer cells through caudal arteries
Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimers disease brain
An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimers disease
Magnetic drug targeting: a novel treatment for intramedullary spinal cord tumors
Glial acetate metabolism is increased following a 72-h fast in metabolically healthy men and correlates with susceptibility to hypoglycemia
Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-β on microglial accumulation
A three-dimensional human neural cell culture model of Alzheimer's disease
A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimers disease
Repeated exposure to heat stress induces mitochondrial adaptation in human skeletal muscle
Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates
Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures
Gene exchange drives the ecological success of a multi-host bacterial pathogen
Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory
Topical curcumin nanocarriers are neuroprotective in eye disease
Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3
Ex vivo biomechanical characterization of syringe-needle ejections for intracerebral cell delivery
Compressed collagen enhances stem cell therapy for corneal scarring
Human limbal biopsy-derived stromal stem cells prevent corneal scarring
Concise review: stem cells in the corneal stroma
Association between the New York sepsis care mandate and in-hospital mortality for pediatric sepsis
Smart surgical catheter for c-reactive protein sensing based on an imperceptible organic transistor
Human pluripotent reprogramming with CRISPR activators
Smart bandage for monitoring and treatment of chronic wounds
Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells
ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma
Anti-tumour necrosis factor therapy for Dupuytren's disease: a randomised dose response proof of concept phase 2a clinical trial
Thermal proteome profiling in bacteria: probing protein state in vivo
Ras and rap signal bidirectional synaptic plasticity via distinct subcellular microdomains
DNA-induced liquid phase condensation of cGAS activates innate immune signaling
Unique Francisella phosphatidylethanolamine acts as a potent anti-inflammatory lipid
Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein
Discovery of UDP-glycosyltransferases and BAHD-acyltransferases involved in the biosynthesis of the anti-diabetic plant metabolite montbretin
Changes in pain intensity following discontinuation of long-term opioid therapy for chronic non-cancer pain
Sampling molecular conformations and dynamics in a multiuser virtual reality framework
Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance
Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program
Continuous biomarker monitoring by particle mobility sensing with single molecule resolution
Control of spreading depression with electrical fields
Human embryonic stem cellderived cardiomyocytes restore function in infarcted hearts of non-human primates
Costs and benefits of provocation in bacterial warfare
Sympathetic neuronal activation triggers myeloid progenitor proliferation and differentiation
A Ca2 -stimulated exosome release pathway in cancer cells is regulated by Munc13-4
Multiscale analysis of independent Alzheimers cohorts finds disruption of molecular, genetic, and clinical networks by human herpesvirus
Locally coordinated synaptic plasticity of visual cortex neurons in vivo
Resistance to enediyne antitumor antibiotics by sequestration
Newfound effect of N -acetylaspartate in preventing and reversing aggregation of amyloid-beta in vitro
How diverse retinal functions arise from feedback at the first visual synapse
Precision therapeutic targeting of human cancer cell motility
A naturally occurring antiviral ribonucleotide encoded by the human genome
Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vessels
The Drosophila immune deficiency pathway modulates enteroendocrine function and host metabolism
Therapeutic luminal coating of the intestine
Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure
Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir
Potent laminin-inspired antioxidant regenerative dressing accelerates wound healing in diabetes
BAFF neutralization aggravates atherosclerosis
Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis
Hippocampal calcifications: risk factors and association with cognitive function
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinsons disease
Human plasma and serum extracellular small RNA reference profiles and their clinical utility
Association between systolic blood pressure and dementia in the Whitehall II cohort study: role of age, duration, and threshold used to define hypertension
Cost-effectiveness analysis of biopsy strategies for endometrial cancer diagnosis in women with postmenopausal bleeding: Pipelle sampling curette versus dilatation & curettage
Gestational changes in buprenorphine exposure: a physiologically based pharmacokinetic analysis
Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion delivery to neuroinflammation of the sciatic nerve in rat
PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis
Clinical trials in a dish: a perspective on the coming revolution in drug development
Ultra-protective mechanical ventilation without extra-corporeal carbon dioxide removal for acute respiratory distress syndrome
Testosterone is an endogenous regulator of BAFF and splenic B cell number
Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance
TMS-induced neuronal plasticity enables targeted remodeling of visual cortical maps
BigSCale: an analytical framework for big-scale single-cell data
Computationally identified novel agonists for GPRC6A
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer
Extracellular matrix-based materials for regenerative medicine
Assessment of follow-up care after emergency department presentation for mild traumatic brain injury and concussion: results from the TRACK-TBI study
A randomized trial of a family-support intervention in intensive care units
Restoring vision
Expanded autologous regulatory T-lymphocyte infusions in ALS
A causal mechanism for childhood acute lymphoblastic leukaemia
Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response
Xenoprotein engineering via synthetic libraries
Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria
3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk
Analysis of red blood cell partitioning at bifurcations in simulated microvascular networks
Associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults
Microfluidics-enabled multimaterial maskless stereolithographic bioprinting
Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke
The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development
Procalcitonin-guided use of antibiotics for lower respiratory tract infection
Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS O-antigen
S-nitrosylation of β-arrestins biases receptor signaling and confers ligand independence
Spatial mutation patterns as markers of early colorectal tumor cell mobility
Staphylococcus aureus utilizes host-derived lipoprotein particles as sources of fatty acids
Sheathless inertial cell focusing and sorting with serial reverse wavy channel structures
Benefits and safety of dietary protein for bone healthan expert consensus paper endorsed by the European Society for Clinical and Economical Aspects of Osteopororosis, Osteoarthritis, and Musculoskeletal Diseases and by the International Osteoporos
Dual-wavelength 3D photoacoustic imaging of mammalian cells using a photoswitchable phytochrome reporter protein
Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis
Have we made progress with educational services for students with TBI
NDF, a nucleosome destabilizing factor that facilitates transcription through nucleosomes
Sharpening of hierarchical visual feature representations of blurred images
Human gut microbiota predicts susceptibility to Vibrio cholera infection
Negative feedback phosphorylation of Gγ subunit Ste18 and the Ste5 scaffold synergistically regulates MAPK activation in yeast
Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2MPER region
Bone marrow is a major parasite reservoir in Plasmodium vivax infection
Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis
TAR DNA-binding protein 43 and disrupted in schizophrenia 1 coaggregation disrupts dendritic local translation and mental function in frontotemporal lobar degeneration
Coarse particulate matter (PM2.510) in Los Angeles Basin air induces expression of inflammation and cancer biomarkers in rat brains
Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning
Validating the concept of mutational signatures with isogenic cell models
Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling
Impact of healthy lifestyle factors on life expectancies in the US population
Enzymatic or in vivo installation of propargyl groups in combination with click chemistry for the enrichment and detection of methyltransferase target sites in RNA
Oral administration and detection of a near-infrared molecular imaging agent in an orthotopic mouse model for breast cancer screening
Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP PS1 double transgenic rat model of Alzheimers disease
DNA methylation and regulatory elements during chicken germline stem cell differentiation
Spatial heterogeneity and evolutionary dynamics modulate time to recurrence in continuous and adaptive cancer therapies
Multifunctional biophotonic nanostructures inspired by the longtail glasswing butterfly for medical devices
Precise multimodal optical control of neural ensemble activity
Shared strategies for β-lactam catabolism in the soil microbiome
Radiomic features on MRI enable risk categorization of prostate cancer patients on active surveillance: preliminary findings
Training a cell-level classifier for detecting basal-cell carcinoma by combining human visual attention maps with low-level handcrafted features
A deep-learning classifier identifies patients with clinical heart failure using whole-slide images of H&E tissue
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis
Long ncRNA A-ROD activates its target gene DKK1 at its release from chromatin
Proton-pump inhibitors and long-term risk of community-acquired pneumonia in older adults
A new method for the high-precision assessment of tumor changes in response to treatment
Cardiac mTORC1 dysregulation impacts stress adaptation and survival in Huntington's disease
Drought-sensitivity of fine dust in the U.S. Southwest: Implications for air quality and public health under future climate change
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
Neuropsychological predictors of long-term (10 years) mild cognitive impairment stability
Age is relativeimpact of donor age on induced pluripotent stem cell-derived cell functionality
An exome-wide sequencing study of lipid response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort
In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design
Neoadjuvant PD-1 blockade in resectable lung cancer
High-speed live-cell interferometry: a new method for quantifying tumor drug resistance and heterogeneity
The long non‐coding RNA Paupar promotes KAP1‐dependent chromatin changes and regulates olfactory bulb neurogenesis
An in vivo model of functional and vascularized human brain organoids
A single injection of crystallizable fragment domainmodified antibodies elicits durable protection from SHIV infection
Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M diffuse midline gliomas
Risk and prognosis of cancer after lower limb arterial thrombosis
The dynamics of concussion: mapping pathophysiology, persistence, and recovery with causal-loop diagramming
Artificial intelligence estimation of carotid-femoral pulse wave velocity using carotid waveform
Use of antiepileptic drugs and dementia risk-an analysis of Finnish health register and German health insurance data
Highly scalable generation of DNA methylation profiles in singles cells
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector
Hemodynamic forces tune the arrest, adhesion, and extravasation of circulating tumor cells
Adipocyte p62/SQSTM1 suppresses tumorigenesis through opposite regulations of metabolism in adipose tissue and tumor
Simultaneous lineage tracing and cell-type identification using CRISPR-Cas9-induced genetic scars
Machine learning detects pan-cancer ras pathway activation in The Cancer Genome Atlas
State estimation for a penicillin fed-batch process combining particle filtering methods with online and time delayed offline measurements
Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency
Proprioceptive and cutaneous sensations in humans elicited by intracortical microstimulation
Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding
APC inhibits ligand-independent Wnt signaling by the clathrin endocytic pathway
Evaluation of 1C-Me-NB1 as a potential PET radioligand for measuring GluN2B-containing NMDA receptors, drug occupancy, and receptor cross talk
A global transcriptional network connecting noncoding mutations to changes in tumor gene expression
Nanoengineered injectable hydrogels for wound healing application
MicroRNA-17-92 is required for T-cell and B-cell pathogenicity in chronic graft-versus-host disease in mice
Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis
Transcatheter laceration of aortic leaflets to prevent coronary obstruction during transcatheter aortic valve replacement
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD in healthy middle-aged and older adults
Complete biosynthesis of noscapine and halogenated alkaloids in yeast
Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion delivery to neuroinflammation of the sciatic nerve in rat
Large volume syringe pump extruder for desktop 3D printers
Referral regions for time-sensitive acute care conditions in the United States
Genome-wide somatic variant calling using localized colored de Bruijn graphs
Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice
SpdC, a novel virulence factor, controls histidine kinase activity in Staphylococcus aureus
Mutations in PMPCB encoding the catalytic subunit of the mitochondrial presequence protease cause neurodegeneration in early childhood
Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A
Design and syntheses of highly potent teixobactin analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in vitro and in vivo
Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids
Suppression of diabetes by accumulation of non-islet-specific CD8 effector T cells in pancreatic islets
Thyroid disrupting chemicals and brain development: an update
Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
Reconfigurable paramagnetic microswimmers: Brownian motion affects non-reciprocal actuation
A bit-encoding based new data structure for time and memory efficient handling of spike times in an electrophysiological setup
Dynamic protein assembly by programmable DNA strand displacement
Phase 1 clinical study of an embryonic stem cellderived retinal pigment epithelium patch in age-related macular degeneration
Intracranial metastasis in fibrolamellar hepatocellular carcinoma
Genetically encoded lipidpolypeptide hybrid biomaterials that exhibit temperature-triggered hierarchical self-assembly
EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans
Linear assembly of a human centromere on the Y chromosome
Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis
Apixaban in patients at risk of stroke undergoing atrial fibrillation ablation
Capture Hi-C identifies putative target genes at 33 breast cancer risk loci
Mid-infrared imaging in breast cancer tissue: an objective measure of grading breast cancer biopsies
Antibiotic-induced population fluctuations and stochastic clearance of bacteria
Nanofibrous peptide hydrogel elicits angiogenesis and neurogenesis without drugs, proteins, or cells
A breathing atom-transfer radical polymerization: fully oxygen-tolerant polymerization inspired by aerobic respiration of cells
Solid-phase synthesis of protein-polymers on reversible immobilization supports
Learning by neural reassociation
Balanced crystalloids versus saline in noncritically ill adults
4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses
Skin electronics from scalable fabrication of an intrinsically stretchable transistor array
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms
Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor
Sexual dimorphism in the behavioral responses and the immuno-endocrine status in D-galactose induced aging
Cognitive functioning after hematopoietic cell transplantation for hematologic malignancy: results from a prospective longitudinal study
Association of epidural stimulation with cardiovascular function in an individual with spinal cord injury
RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells
Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice
Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumor growth
Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription
A vitamin B12 conjugate of Exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents
Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles
The polyploid state plays a tumor-suppressive role in the liver
Rehealable, fully recyclable, and malleable electronic skin enabled by dynamic covalent thermoset nanocomposite
Intra-atrial dyssynchrony during sinus rhythm predicts recurrence after the first catheter ablation for atrial fibrillation
Positively selected enhancer elements endow osteosarcoma cells with metastatic competence
Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells
Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins
Programming of Schwann cells by Lats1/2-TAZ/YAP signaling drives malignant peripheral nerve sheath tumorigenesis
Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood
Aggressive triple negative breast cancers have unique molecular signature on the basis of mitochondrial genetic and functional defects
Ribosome incorporation into somatic cells promotes lineage transdifferentiation towards multipotency
Ibrutinib inhibition of ERBB4 reduces cell growth in a WNT5A-dependent manner
Cataract in patients with diabetes mellitusincidence rates in the UK and risk factors
Bioresorbable optical fiber Bragg gratings
Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia
Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics
Differential association of microvascular attributions with cardiovascular disease in patients with long duration of type 1 diabetes
In vivo wireless photonic photodynamic therapy
Relaxin reverses inflammatory and immune signals in aged hearts
Mimicking embedded vasculature structure for 3D cancer on a chip approaches through micromilling
De novoexpression of human polypeptideN-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium
Chromosomal instability during neurogenesis in Huntington's disease
Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo
Specific expression of PD-L1 in RELA-fusion supratentorial ependymoma: Implications for PD-1-targeted therapy
Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease
Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes
Structures of human PRC2 with its cofactors AEBP2 and JARID2
Male-specific IL-33 expression regulates sex-dimorphic EAE susceptibility
Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response
Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration: Vitamin B2 (Riboflavin) in cancer therapy
Sensitization of hypoxic tumors to radiation therapy using ultrasound sensitive oxygen microbubbles
Tumor-specific T-Cells engineered to overcome tumor immune evasion induce clinical responses in patients with relapsed Hodgkin lymphoma
Safety and efficacy of immunotherapy with the recombinant B-cell epitopebased grass pollen vaccine BM32
Primary cilium-mediated retinal pigment epithelium maturation is disrupted in ciliopathy patient cells
Removal of oral biofilm on an implant fixture by a cavitating jet
Modeling the ACMG/AMP variant classification guidelines as a Bayesian classification framework
Detection and localization of surgically resectable cancers with a multi-analyte blood test
Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay
Loss of an androgen-inactivating and isoform-specific HSD17B4 splice form enables emergence of castration-resistant prostate cancer
Co-activation of GR and PPARγ in murine skin prevents worsening of atopic march
Structures of β-klotho reveal a zip code-like mechanism for endocrine FGF signalling
Genomic and proteomic resolution of heterochromatin and its restriction of alternate fate genes
Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning
Polygenic contribution in individuals with early-onset coronary artery disease
Multi-day rhythms modulate seizure risk in epilepsy
Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice
Reprogramming the activatable peptide display function of adeno-associated virus nanoparticles
Hedgehog pathway drives fusion-negative rhabdomyosarcoma initiated from non-myogenic endothelial progenitors
Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells
TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
A TFIID-SAGA perturbation that targets MYB and suppresses acute myeloid leukemia
Glial responses to implanted electrodes in the brain
Enhancing recovery from sepsis, a review
Endogenous reprogramming of alpha cells into beta cells, induced by viral gene therapy, reverses autoimmune diabetes
Reversible retinal vessel closure from VEGF-induced leukocyte plugging
A tunable microfluidic 3D stenosis model to study leukocyte-endothelial interactions in atherosclerosis
Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
Programmed platelet derived growth factor‐bb and bone morphogenetic protein‐2 delivery from a hybrid calcium phosphate/alginate scaffold
Modern therapeutic approaches for noninfectious ocular diseases involving inflammation
TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis
Food-grade cationic antimicrobial ε-polylysine transiently alters the gut microbial community and predicted metagenome function in CD-1 mice
Interferon-beta represses cancer stem cell properties in triple-negative breast cancer
EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer
Substrate-driven chemotactic assembly in an enzyme cascade
The Std1 activator of the Snf1/AMPK kinase controls glucose response in yeast by a regulated protein aggregation
Direct electrical stimulation of the amygdala enhances declarative memory in humans
The oncolytic virus, MG1, targets and eliminates latently HIV-1-infected cells: implications for an HIV cure
ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs
Sphingosine and dihydrosphingosine as biomarkers for multiple sclerosis identified by metabolomic profiling using coupled UPLC-MS
Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
Efficacy of educational video game versus traditional educational apps at improving physician decision making in trauma triage: randomized controlled trial
Effect of high-intensity treadmill exercise on motor symptoms in patients with de novo Parkinson disease: a phase 2 randomized clinical trial
Injecting instructions into premotor cortex
Simple detection of telomere fusions in pancreatic cancer, intraductal papillary mucinous neoplasm, and pancreatic cyst fluid
Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation
Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle
Higher blood urea nitrogen is associated with increased risk of incident diabetes mellitus
Efficient protein production by yeast requires global tuning of metabolism
Clinical implications of Plasmodium resistance to atovaquone/proguanil: a systematic review and meta-analysis
Runx3 programs CD8 T cell residency in non-lymphoid tissues and tumours
mTORC2 promotes tumorigenesis via lipid synthesis
Do viruses exchange genes across superkingdoms of life?
Second-degree burns with six etiologies treated with autologous noncultured cell-spray grafting
Nitro-oleic acid (NO2OA) release enhances regional angiogenesis in a rat abdominal wall defect model
Heart valve scaffold fabrication: Bioinspired control of macro-scale morphology, mechanics and micro-structure
A melanin-mediated cancer immunotherapy patch
TDP-43 accelerates age-dependent degeneration of interneurons
Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
Thermostable exoshells fold and stabilize recombinant proteins
Nonimmune cells equipped with T-cell-receptorlike signaling for cancer cell ablation
Inhibition of TRF1 telomere protein impairs tumor initiation and progression in glioblastoma mouse models and patient-derived xenografts
ER-associated degradation regulates Alzheimers amyloid pathology and memory function by modulating γ-secretase activity
A data-driven modeling approach to identify disease-specific multi-organ networks driving physiological dysregulation
Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
Inflammation-induced IgA cells dismantle anti-liver cancer immunity
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer
A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy
Single-cell virology: on-chip investigation of viral infection dynamics
Near-infrared remotely triggered drug-release strategies for cancer treatment
Regeneration of the entire human epidermis using transgenic stem cells
Clinical decision support for in-hospital AKI
Understanding tissue-specific gene regulation
Fibroblast activation protein augments progression and metastasis of pancreatic ductal adenocarcinoma
Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling
Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice
Isoform‐specific localization of DNMT3A regulates DNA methylation fidelity at bivalent CpG islands
Virtual reality improves embodiment and neuropathic pain caused by spinal cord injury
Long term effect of intensive lifestyle intervention on cerebral blood flow
Modulation of inflammation in brain: a matter of fat
Synthetic beta cells for fusion-mediated dynamic insulin secretion
Safety and efficacy of focused ultrasound thalamotomy for patients with medication-refractory, tremor-dominant Parkinson Disease
Aptamer-functionalized neural recording electrodes for the direct measurement of cocaine in vivo
Transcription factor ISX mediates the cross talk between diet and immunity
PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Atopic asthmatic immune phenotypes associated with airway microbiota and airway obstruction
Synergistic malaria vaccine combinations identified by systematic antigen screening
Small GTPase ARF6 controls VEGFR2 trafficking and signaling in diabetic retinopathy
Isolation of exosomes from whole blood by integrating acoustics and microfluidics
Validation of a metastatic assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy
Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets
Synthetic hydrogels for human intestinal organoid generation and colonic wound repair
Novel nanoparticles with Cr3 substituted ferrite for self-regulating temperature hyperthermia
PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals
Genetic effects on gene expression across human tissues
Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data
Sensitivity to BUB1B inhibition defines an alternative classification of glioblastoma
CCND2 overexpression enhances the regenerative potency of human induced pluripotent stem cell-derived cardiomyocytes: remuscularization of injured ventricle
A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells
Bioinspired flexible microfluidic shear force sensor skin
Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche
Is abdominal hypopressive technique effective in the prevention and treatment of pelvic floor dysfunction? Marketing or evidence from high-quality clinical trials?
Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma
Determination of the impact of melanoma surgical timing on survival using the National Cancer Database
Cbfβ governs osteoblast−adipocyte lineage commitment through enhancing β-catenin signaling and suppressing adipogenesis gene expression
Angiopoietin-like 4 induces a β-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen expression
A synthetic DNA-binding inhibitor of SOX2 guides human induced pluripotent stem cells to differentiate into mesoderm
Induced pluripotent stem cell-derived neural stem cell therapy enhances recovery in an ischemic stroke pig model
Tension creates an endoreplication wavefront that leads regeneration of epicardial tissue
Effects of autogenous bone marrow aspirate concentrate on radiographic integration of femoral condylar osteochondral allografts
Prevention of Alzheimer's Disease: lessons learned and applied
Chemical modulation of in vivo macrophage function with subpopulation-specific fluorescent prodrug conjugates
Prostaglandin E1 and its analog misoprostol inhibit human CML stem cell self-renewal via EP4 receptor activation and repression of AP-1
A novel neural prediction error found in anterior cingulate cortex ensembles
O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking
Deletion of interleukin 1 receptor-associated kinase 1 (Irak1) improves glucose tolerance primarily by increasing insulin sensitivity in skeletal muscle
Model-based design of RNA hybridization networks implemented in living cells
Mechanistic investigation of the specific anticancer property of artemisinin and its combination with aminolevulinic acid for enhanced anticolorectal cancer activity
A recombinant human ADAMTS-13: first-in-human study evaluating pharmacokinetics, safety and tolerability in cTTP patients
A cargo-sorting DNA robot
A predictive model for selective targeting of the Warburg Effect through GAPDH inhibition with a natural product
Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells
Locally induced adipose tissue browning by microneedle patch for obesity treatment
Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans
Shape-specific nanoceria mitigate oxidative stress-induced calcification in primary human valvular interstitial cell culture
In vivo induction of regulatory T cells promotes allergen tolerance and suppresses allergic contact dermatitis
Tau exacerbates excitotoxic brain damage in an animal model of stroke
Distinct mesenchymal lineages and niches promote epithelial self-renewal and myofibrogenesis in the lung
Optical coherence tomography identifies outer retina thinning in frontotemporal degeneration
A functional genomics predictive network model identifies regulators of inflammatory bowel disease
High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling
The burden and etiology of diarrheal illness in developing countries
Taxane-mediated radiosensitization derives from chromosomal missegregation on tripolar mitotic spindles orchestrated by AURKA and TPX2
Human plasma metabolomics study across all stages of age-related macular degeneration identifies potential lipid biomarkers
Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella
Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis
A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study
β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinsons disease
LMO1 synergizes with MYCN to promote neuroblastoma initiation and metastasis
Signals from the adipose microenvironment and the obesitycancer linka systematic review
Pharmacological inhibition of the DNA damage checkpoint prevents radiation-induced oocyte death
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
CNPY2 is a key initiator of the PERKCHOP pathway of the unfolded protein response
Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice
Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms
The deacetylase HDAC6 mediates endogenous neuritic tau pathology
Synthetic quorum sensing in model microcapsule colonies
Microbial regulation of microRNA expression in the amygdala and prefrontal cortex
Peripherally derived FGF21 promotes remyelination in the central nervous system
Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis
Feeding releases endogenous opioids in humans
Anti-inflammatory therapy with canakinumab for atherosclerotic disease
Stimulation of functional neuronal regeneration from Müller glia in adult mice
Microglia turnover with aging and in an Alzheimer´s model via long-term in vivo single-cell imaging
Prolonged human neural stem cell maturation supports recovery in injured rodent CNS
Proteasome activity regulates CD8 T lymphocyte metabolism and fate specification
Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche
Neuroprotective effects of trigeminal nerve stimulation in severe traumatic brain injury
Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells
BACE inhibition-dependent repair of Alzheimer's pathophysiology
Mesoscopic adaptive resolution scheme toward understanding of interactions between sickle cell fibers
Transcriptomic biomarkers to discriminate bacterial from nonbacterial infection in adults hospitalized with respiratory illness
Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy
Cell segregation and border sharpening by Eph receptorephrin-mediated heterotypic repulsion
Computational integration of nanoscale physical biomarkers and cognitive assessments for Alzheimers disease diagnosis and prognosis
The role of retinal carotenoids and age on neuroelectric indices of attentional control among early to middle-aged adults
Structural and functional substitution of deleted primary sensory neurons by new growth from intrinsic spinal cord nerve cells: an alternative concept in reconstruction of spinal cord circuits
Necroptosis activation in Alzheimer's disease
Functional annotation of chemical libraries across diverse biological processes
Inverted battery design as ion generator for interfacing with biosystems
Genome editing abrogates angiogenesis in vivo
Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish
Triggerable tough hydrogels for gastric resident dosage forms
Synthetic quorum sensing in model microcapsule colonies
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Comparison of algorithms for the detection of cancer drivers at subgene resolution
Deformation correction for image-guided liver surgery: An intraoperative assessment of fidelity
Dll4 and Notch signalling couples sprouting angiogenesis and artery formation
Transancestral mapping and genetic load in systemic lupus erythematosus
Prosthetic valve endocarditis after surgical aortic valve replacement
Dynamic responses of the adrenal steroidogenic regulatory network
Infant gut microbiome associated with cognitive development
Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis
Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies
Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction
RNA stores tau reversibly in complex coacervates
Comparison of the VA and NIDILRR TBI model system cohorts
Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis
Pretreatment fasting plasma glucose and insulin modify dietary weight loss success: results from 3 randomized clinical trials
Tumor-targeted and clearable human protein-based MRI nanoprobes
Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis
Recruitment of Epac2A to insulin granule docking sites regulates priming for exocytosis
Surface chemistry for cytosolic gene delivery and photothermal transgene expression by gold nanorods
Cellular prion protein (PrPC) in the development of Merlindeficient tumors
High-speed and scalable whole-brain imaging in rodents and primates
Nanonet force microscopy for measuring forces in single smooth muscle cells of the human aorta
Comorbid conditions delay diagnosis of colorectal cancer: a cohort study using electronic primary care records
Lutein exerts anti-inflammatory effects in patients with coronary artery disease
Whole-body profiling of cancer metastasis with single-cell resolution
Microglial inflammatory signaling orchestrates the hypothalamic immune response to dietary excess and mediates obesity susceptibility
Inhibition of IKKɛ and TBK1 improves glucose control in a subset of patients with type 2 diabetes
Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging
Cell-cycle dynamics of chromosomal organization at single-cell resolution
Risk of hospitalization with neurodegenerative disease after moderate-to-severe traumatic brain injury in the working-age population: A retrospective cohort study using the Finnish national health registries
An immunogenic personal neoantigen vaccine for patients with melanoma
Direct imaging of protein stability and folding kinetics in hydrogels
Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma
Sculpting neurotransmission during synaptic development by 2D nanostructured interfaces
A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay
Selective optogenetic control of purkinje cells in monkey cerebellum
Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock
A calcium- and light-gated switch to induce gene expression in activated neurons
Landscape of innovation for cardiovascular pharmaceuticals: from basic science to new molecular entities
Adaptive capacity: an evolutionary neuroscience model linking exercise, cognition, and brain health
Rat intersubjective decisions are encoded by frequency-specific oscillatory contexts
Zolpidem for the treatment of neurologic disorders: a systematic review
Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts
Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices
Left ventricular dysfunction switches mesenchymal stromal cells toward an inflammatory phenotype and impairs their reparative properties via toll-like receptor-4 clinical perspective
Ratchet-like polypeptide translocation mechanism of the AAA disaggregase Hsp104
Microbial genetic composition tunes host longevity
Antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase
A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasite
Three mutations switch H7N9 influenza to human-type receptor specificity
Hypothalamic regulation of distinct adult neural stem cells and neurogenesis
Tropism, intracerebral distribution, and transduction efficiency of HIV- and SIV-based lentiviral vectors after injection into the mouse brain: a qualitative and quantitative in vivo study
Sequential self-assembly of DNA functionalized droplets
Atopic dermatitis and risk of hypertension, type-2 diabetes, myocardial infarction and stroke in a cross-sectional analysis from the Canadian Partnership for Tomorrow Project
Pulsed cavitational ultrasound softening
Potent inhibitor of drug-resistant HIV-1 strains identified from the medicinal plant Justicia gendarussa
A genetic polymorphism repurposes the G-protein coupled and membrane-associated estrogen receptor GPER to a transcription factor-like molecule promoting paracrine signaling between stroma and breast carcinoma cells
In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs
Drag reducing polymers decrease hepatic injury and metastases after liver ischemia-reperfusion
Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes
HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia
A novel strategy to engineer pre-vascularized full-length dental pulp-like tissue constructs
Polarity of varicosity initiation in central neuron mechanosensation
Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa
Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations
Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham Study
A scalable platform to identify fungal secondary metabolites and their gene clusters
Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis
ACK1/TNK2 regulates histone H4 Tyr88-phosphorylation and AR gene expression in castration-resistant prostate cancer
A systems biology approach identifies FUT8 as a driver of melanoma metastasis
Impact of vitamin A and carotenoids on the risk of tuberculosis progression
Obesity accelerates Alzheimer-related pathology in APOE4 but not APOE3 mice
Tactile defensiveness and impaired adaptation of neuronal activity in the Fmr1 knockout mouse model of autism
Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)
Use of prescribed opioids before and after bariatric surgery: prospective evidence from a U.S. multicenter cohort study
Adult murine cardiomyocytes exhibit regenerative activity with cell cycle reentry through STAT3 in the healing process of myocarditis
Perirhinal firing patterns are sustained across large spatial segments of the task environment
Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation
JunB is essential for IL-23-dependent pathogenicity of Th17 cells
Childhood predictors of cardiovascular disease in adulthood. A systematic review and meta-analysis
Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia
Protein-free formation of bone-like apatite: New insights into the key role of carbonation
GLUT 1 receptor expression and circulating levels of fasting glucose in high grade serous ovarian cancer
Specification and diversification of pericytes and smooth muscle cells from mesenchymoangioblasts
Contralesional braincomputer interface control of a powered exoskeleton for motor recovery in chronic stroke survivors
Use of a pedicled omental flap to reduce inflammation and vascularize an abdominal wall patch
Endothelial TLR4 and the microbiome drive cerebral cavernous malformations
Mutant KRAS promotes malignant pleural effusion formation
Light-inducible antimiR-92a as a therapeutic strategy to promote skin repair in healing-impaired diabetic mice
SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production
Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation
TIAM1 variants improve clinical outcome in neuroblastoma
Quantitative erythrocyte omega-3 EPA plus DHA levels are related to higher regional cerebral blood flow on brain SPECT
Targeting latency-associated peptide promotes antitumor immunity
Neonatal expression of RNA-binding protein IGF2BP3 regulates the human fetal-adult megakaryocyte transition
Maintenance of persistent activity in a frontal thalamocortical loop
The complex genetics of hypoplastic left heart syndrome
Compositional changes in the gut mucus microbiota precede the onset of colitis-induced inflammation
The host ubiquitin-dependent segregase VCP/p97 is required for the onset of human cytomegalovirus replication
Outcomes of patients with double-hit lymphoma who achieve first complete remission
A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis
Evaluating the safety of β-interferons in MS
Humoral immune reconstitution kinetics following allogeneic hematopoietic stem cell transplantation in children: a maturation block of IgM memory B cells may lead to impaired antibody immune reconstitution
Gut microbiome function predicts response to anti-integrin biologic therapy in inflammatory bowel diseases
Topical delivery of anti-VEGF drugs to the ocular posterior segment using cell-penetrating peptides
The single-parameter, structure-based IsoPSA assay demonstrates improved diagnostic accuracy for detection of any prostate cancer and high-grade prostate cancer compared to a concentration-based assay of total prostate-specific antigen
Photosensitization priming of tumor microenvironments improves delivery of nanotherapeutics via neutrophil infiltration
Identification of targetable ALK rearrangements in pancreatic ductal adenocarcinoma
Impact of genomic profiling on the treatment and outcomes of patients with advanced gastrointestinal malignancies
Platelets subvert T cell immunity against cancer via GARP-TGFβ axis
Meeting report for NIH 2016 progenitor cell biology consortium cardiovascular tissue engineering 2016
Signalome-wide assessment of host cell response to hepatitis C virus
Role of Akt-independent mTORC1 and GSK3β signaling in sublethal NMDA-induced injury and the recovery of neuronal electrophysiology and survival
High-throughput, low-loss, low-cost, and label-free cell separation using electrophysiology-activated cell enrichment
Identification of cardiac hemo-vascular precursors and their requirement of sphingosine-1-phosphate receptor 1 for heart development
County-level cumulative environmental quality associated with cancer incidence
CHD4 has oncogenic functions in initiating and maintaining epigenetic suppression of multiple tumor suppressor genes
Red blood cells for glucose-responsive insulin delivery
Cell-specific pallidal intervention induces long-lasting motor recovery in dopamine-depleted mice
Population-based stroke and dementia incidence trends: age and sex variations
Interaction of 12/15 lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved post-myocardial infarction healing
Birinapant sensitizes platinum-resistant carcinomas with high levels of cIAP to carboplatin therapy
Brd4 modulates the innate immune response through Mnk2eIF4E pathway-dependent translational control of IκBα
The future of asthma research and development: a roadmap from the European Asthma Research and Innovation Partnership (EARIP)
Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models
MicroRNA-210 enhances fibrous cap stability in advanced atherosclerotic lesions novelty and significance
Evidence of strain structure in Plasmodium falciparum var gene repertoires in children from Gabon, West Africa
Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila
Trial of transplantation of HCV-infected kidneys into uninfected recipients
MAN2A1FER fusion gene is expressed by human liver and other tumor types and has oncogenic activity in mice
Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene
Data-driven modeling for precision medicine in pediatric acute liver failure
Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors
The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB
Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations
Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control
Differentiation of V2a interneurons from human pluripotent stem cells
Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors
Raft-based sphingomyelin interactions revealed by new fluorescent sphingomyelin analogs
Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells
iPSC-derived human microglia-like cells to study neurological diseases
Ultrafast laser-probing spectroscopy for studying molecular structure of protein aggregates
Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer
Access granted: iRGD helps silicasome-encased drugs breach the tumor barrier
PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8 T cells
Detection of interferon alpha protein reveals differential levels and cellular sources in disease
IL-36γ signaling controls the induced regulatory T cellTh9 cell balance via NFκB activation and STAT transcription factors
mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert)
HGFA is an injury-regulated systemic factor that induces the transition of stem cells into GAlert
Dynamic range adaptation in primary motor cortical populations
In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein
Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche
Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis
Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance
Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia
Report on the National Eye Institute audacious goals initiative: replacement of retinal ganglion cells from endogenous cell sources
Increasing efficiency of preclinical research by group sequential designs
Technology versus biology: the limits of pre‐implantation genetic screening
Early-life antibiotic treatment enhances the pathogenicity of CD4 T cells during intestinal inflammation
Melanoma cells undergo aggressive coalescence in a 3D Matrigel model that is repressed by anti-CD44
Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming
Flexible and stretchable nanowire-coated fibers for optoelectronic probing of spinal cord circuits
The burden of neurological disease in the United States: a summary report and call to action
ANGPTL3 deficiency and protection against coronary artery disease
CRISPRCas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome
Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells
In vitro and in vivo evaluation of a novel integrated wearable artificial lung
Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimers-like impairment in mice
Confined space facilitates G-quadruplex formation
Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix
Reduced DNA methylation and psychopathology following endogenous hypercortisolism a genome-wide study
Hybrid inorganic-organic capsules for efficient intracellular delivery of novel siRNAs against influenza A (H1N1) virus infection
Rehabilitation for people living with dementia: A practical framework of positive support
Microscopic characterization of the Brazilian giant samba virus
Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle
Therapy of primary and metastatic liver cancer by human iPS cell-derived myeloid cells producing interferon-β
Proteogenomic integration reveals therapeutic targets in breast cancer xenografts
Inflammation boosts bacteriophage transfer between Salmonella spp.
Classification and adaptive behavior prediction of children with autism spectrum disorder based upon multivariate data analysis of markers of oxidative stress and DNA methylation
Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer
Germline mutations in the Kallikrein 6 region and predisposition for aggressive prostate cancer
Randomized trial of a hypofractionated radiation regimen for the treatment of localized prostate cancer
Stable and potent selenomab-drug conjugates
Electroacupuncture promotes CNS-dependent release of mesenchymal stem cells
Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation
An adipo-biliary-uridine axis that regulates energy homeostasis
Structure of the active form of human origin recognition complex and its ATPase motor module
Reduced regional grey matter volumes in pediatric obstructive sleep apnea
Eosinophils are key regulators of perivascular adipose tissue and vascular functionality
Phase separation of C9orf72 dipeptide repeats perturbs stress granule dynamics
Inclisiran in patients at high cardiovascular risk with elevated LDL cholesterol
Safety observations with three years of denosumab exposure: comparison between subjects who received denosumab during the randomized FREEDOM trial and subjects who crossed over to denosumab during the FREEDOM extension
Targeting glutamate signalling in depression: progress and prospects
A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome
Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism
Piloting a remission strategy in type 2 diabetes: results of a randomized controlled trial
Vision loss after intravitreal injection of autologous stem cells for AMD
Structural basis of substrate recognition by the multidrug resistance protein MRP1
Systematic mapping of RNA-chromatin interactions in vivo
Tracking the fate and origin of clinically relevant adoptively transferred CD8 T cells in vivo
The cumulative effects of intravenous antibiotic treatments on hearing in patients with cystic fibrosis
Dietary prebiotics and bioactive milk fractions improve NREM sleep, enhance REM sleep rebound and attenuate the stress-induced decrease in diurnal temperature and gut microbial alpha diversity
Enhanced dynamics of hydrated tRNA on nanodiamond surfaces: a combined neutron scattering and MD simulation study
Analysis of the T cell response to Zika virus and identification of a novel CD8 T cell epitope in immunocompetent mice
Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas
Abnormal capillary vasodynamics contribute to ictal neurodegeneration in epilepsy
Host genotype and gut microbiome modulate insulin secretion and diet-induced metabolic phenotypes
Low serum vitamin D during remission increases risk of clinical relapse in patients with ulcerative colitis
Transient auditory nerve demyelination as a new mechanism for hidden hearing loss
Correlation of long-term results of imatinib in advanced gastrointestinal stromal tumors with next-generation sequencing results
A macrophage relay for long-distance signaling during postembryonic tissue remodeling
Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice
PAK4 interacts with p85 alpha: implications for pancreatic cancer cell migration
RUNX1 cooperates with FLT3-ITD to induce leukemia
Mining the human gut microbiota for immunomodulatory organisms
Titanium dioxide nanoparticle ingestion alters nutrient absorption in an in vitro model of the small intestine
Harnessing catalytic pumps for directional delivery of microparticles in microchambers
Macromolecularly caged carbon nanoparticles for intracellular trafficking via switchable photoluminescence
A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-l-proline
Neuronal activity in ontogeny and oncology
The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein
Perturbations of the anti-ageing hormone Klotho in patients with type 1 diabetes and microalbuminuria
Perinatal nicotine exposure impairs the maturation of glutamatergic inputs in the auditory brainstem
Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy
Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2
Synchrotron x-ray fluorescence nanoprobe reveals target sites for organo-osmium complex in human ovarian cancer cells
Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntingtons disease
Arsenic promotes NF-Κb-mediated fibroblast dysfunction and matrix remodeling to impair muscle stem cell function
A rapid screening method to evaluate the impact of nanoparticles on macrophages
Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA
Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist
IL-27 limits type 2 immunopathology following parainfluenza virus infection
MCT8 deficiency in Purkinje cells disrupts embryonic chicken cerebellar development
Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy
Chemopreventive potential of in vitro fermented nuts in LT97 colon adenoma and primary epithelial colon cells
Comparative effectiveness of vancomycin and metronidazole for the prevention of recurrence and death in patients with Clostridium difficile infection
Alterations in the gut microbiota can elicit hypertension in rats
Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c
External size but not aBMD predicts structural and mass changes for women transitioning through menopause
Experimental measurement of binding energy, selectivity, and allostery using fluctuation theorems
Bone marrow-derived mesenchymal stem cells-derived exosomes promote survival of retinal ganglion cells through miRNA-dependent mechanisms
A non-canonical mismatch repair pathway in prokaryotes
Discovering novel phenotypes with automatically inferred dynamic models: a partial melanocyte conversion in Xenopus
Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke
Feasibility study on cardiac arrhythmia ablation using high-energy heavy ion beams
Wall teichoic acids mediate increased virulence in Staphylococcus aureus
Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment
MicroRNA-194 promotes prostate cancer metastasis by inhibiting SOCS2
Data-driven modeling for precision medicine in pediatric acute liver failure
Noninvasive targeted transcranial neuromodulation via focused ultrasound gated drug release from nanoemulsions
Hysterectomy-corrected cervical cancer mortality rates reveal a larger racial disparity in the United States
Nutritional considerations for healthy aging and reduction in age-related chronic disease
Cryoelectron microscopy maps of human papillomavirus 16 reveal l2 densities and heparin binding site
Pediatric nonDown syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes
An extended fatty liver index to predict non-alcoholic fatty liver disease
Micromotors spontaneously neutralize gastric acid for pH-responsive payload release
Zika virus disrupts molecular fingerprinting of human neurospheres
3D bioprinting of functional human skin: production and in vivo analysis
Post-Ebola reforms: ample analysis, inadequate action
Hyperspectral phasor analysis enables multiplexed 5D in vivo imaging
IL-6 controls resistance to radiation by suppressing oxidative stress via the Nrf2-antioxidant pathway in oral squamous cell carcinoma
The descending diencephalic dopamine system is tuned to sensory stimuli
Sleepiness and sleep-related breathing disorders in myotonic dystrophy and responses to treatment: a prospective cohort study
Health-care-associated infections in neonates, children, and adolescents: an analysis of paediatric data from the European Centre for Disease Prevention and Control point-prevalence survey
Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells
Prevention of dietary-fat-fueled ketogenesis attenuates BRAF V600E tumor growth
The ubiquitin ligase Smurf1 functions in selective autophagy of mycobacterium tuberculosis and anti-tuberculous host defense
Flavivirus infection uncouples translation suppression from cellular stress responses
A comparison of surrogate endpoints for all cause mortality in men with localized unfavorable-risk prostate cancer
Therapeutic targeting of MLL degradation pathways in MLL-rearranged leukemia
Evidence for opposing roles of Celsr3 and Vangl2 in glutamatergic synapse formation
Insights into the mechanistic basis of plasmid-mediated colistin resistance from crystal structures of the catalytic domain of MCR-1
Biomarker signatures of aging
Modular immune organoids with integrin ligand specificity differentially regulate ex vivo B cell activation
MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas
Bortezomib for treatment of therapy-refractory anti-NMDA receptor encephalitis
APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress
Detection of viral RNA in tissues following plasma clearance from an Ebola virus infected patient
Acute plasma tau relates to prolonged return to play after concussion
GelMA encapsulated hDPSCs and HUVECs for dental pulp regeneration
Whole genome relationships among Francisella bacteria of diverse origin define new species and provide specific regions for detection
Nonsteroidal anti-inflammatory drugs and endometrial carcinoma mortality and recurrence
Vav proteins are key regulators of Card9 signaling for innate antifungal immunity
Cancer cell hyperactivity and membrane dipolarity monitoring via raman mapping of interfaced graphene: toward non-invasive cancer diagnostics
Electrically oscillating plasmonic nanoparticles for enhanced DNA vaccination against hepatitis C virus
Mechanisms of bacterial persistence during stress and antibiotic exposure
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease
Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence
Protective immunity elicited by oral immunization of mice with salmonella enterica Serovar Typhimurium Braun Lipoprotein (Lpp) and Acetyltransferase (MsbB) mutants
Influence of donor age on induced pluripotent stem cells
Free serum hemoglobin is associated with brain atrophy in secondary progressive multiple sclerosis
Clonal variation in drug and radiation response among glioma-initiating cells is linked to proneural-mesenchymal transition
A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development
ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice
Sex and race differences in the association between statin use and the incidence of Alzheimer disease
NLRC3 is an inhibitory sensor of PI3KmTOR pathways in cancer
Sentinel lymph node biopsy for patients with early-stage breast cancer: American Society of Clinical Oncology clinical practice guideline update 2016
Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome
Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity
Intrinsic subtype switching and acquired ERBB2/HER2 amplifications and mutations in breast cancer brain metastases
Redefining the invertebrate RNA virosphere
5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients
G-CSF-induced sympathetic tone provokes fever and primes anti-mobilizing functions of neutrophils via PGE2
Reparative effects of interleukin-1 receptor antagonist in young and aged/co-morbid rodents after cerebral ischemia
Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11
eEF2K/eEF2 pathway controls the excitation/inhibition balance and susceptibility to epileptic seizures
Obesity: fermentable carbohydrates increase satiety signals
3D-CLEM reveals that a major portion of mitotic chromosomes is not chromatin
Chronology of onset of mental disorders and physical diseases in mental-physical comorbidity - a national representative survey of adolescents
Structure of a human astrovirus capsid - antibody complex and mechanistic insights into virus neutralization
Synthetic recording and in situ readout of lineage information in single cells
Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer
Fear reduction without fear through reinforcement of neural activity that bypasses conscious exposure
A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood
Association of 3 different antihypertensive medications with hip and pelvic fracture risk in older adults: secondary analysis of a randomized clinical trial
Relationship of lutein and zeaxanthin levels to neurocognitive functioning: an fMRI study of older adults
p15 expression differentiates nevus from melanoma
Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy
ChromoplecticTPM3ALK rearrangement in a patient with inflammatory myofibroblastic tumor who responded to ceritinib after progression on crizotinib
Lactobacillus plantarum attenuates anxiety-related behavior and protects against stress-induced dysbiosis in adult zebrafish
Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Proteomic profiling reveals a specific role for translesion DNA polymerase η in the alternative lengthening of telomeres
Structural analysis of X-Linked Retinoschisis mutations reveals distinct classes which differentially effect retinoschisin function
Functional and genomic architecture of Borrelia burgdorferi-induced cytokine responses in humans
Systemic therapy for previously untreated advanced BRAF-mutated melanoma
Neuroplasticity following anterior cruciate ligament injury: a framework for visual-motor training approaches in rehabilitation
Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimers pathology
Genome dynamics and molecular infection epidemiology of multi-drug resistant Helicobacter pullorum isolates obtained from broiler and country chickens in India
Next-generation sequencing diagnostics of bacteremia in septic patients
Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model
Kidney function after the first kidney stone event
Oxidative guanine base damage regulates human telomerase activity
The spatial structure of correlated neuronal variability
A topical mitochondria-targeted redox cycling nitroxide mitigates oxidative stress induced skin damage
Sensory dynamics of visual hallucinations in the normal population
Shifts in macrophage phenotype at the biomaterial interface via IL-4 eluting coatings are associated with improved implant integration
Statements of agreement from the targeted evaluation and active management (TEAM) approaches to treating concussion meeting held in Pittsburgh, October 15-16, 2015
Inflammation following traumatic brain injury in humans: insights from data-driven and mechanistic models into survival and death
Characterisation of a flavonoid ligand of the fungal protein Alt a 1
NAD replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair
Prospective longitudinal analysis of 2-hydroxyglutarate magnetic resonance spectroscopy identifies broad clinical utility for the management of patients with IDH-mutant glioma
Pharmacologic activation of estrogen receptor increases mitochondrial function, energy expenditure, and brown adipose tissue
Protective effects of mitochondria-targeted antioxidants and statins on cholesterol-induced osteoarthritis
Association between androgen deprivation therapy and risk of dementia
Molecular classification of Crohn's disease reveals two clinically relevant subtypes
Evolution of protein phosphorylation across 18 fungal species
Sustained virologic control in SIV macaques following short term ART and 47-mAb treatment
Is a normal TSH synonymous with euthyroidism in levothyroxine monotherapy?
Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice
Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms
Neuropeptide Y as a biomarker and therapeutic target for neuroblastoma
Defective transcytosis of APP and lipoproteins in human iPSC-derived neurons with familial Alzheimers disease mutations
Validation of a clinical-grade assay to measure donor-derived cell-free DNA in solid organ transplant recipients
Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection
Stretchable materials for robust soft actuators towards assistive wearable devices
Calcium intake from diet and supplements and the risk of coronary artery calcification and its progression among older adults: 10‐year follow‐up of the Multi‐Ethnic Study of Atherosclerosis (MESA)
The p53 pathway controls SOX2-mediated reprogramming in the adult mouse spinal cord
Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells
Aberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development
Circulating CXCR5 PD-1 ICOS follicular T helper cells are increased close to the diagnosis of type 1 diabetes in children with multiple autoantibodies
The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials
The potential health effects of dietary phytoestrogens
Brain Modulyzer: interactive visual analysis of functional brain connectivity
An excitatory cortical feedback loop gates retinal wave transmission in rodent thalamus
Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry
Maternal milk T cells drive development of transgenerational Th1 immunity in offspring thymus
Motor cortex activity predicts response alternation during sensorimotor decisions
Cosmic radiation exposure and persistent cognitive dysfunction
Intracortical microstimulation of human somatosensory cortex
Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimers disease
Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2
A LRRK2-dependent EndophilinA phosphoswitch is critical for macroautophagy at presynaptic terminals
Measuring financial toxicity as a clinically relevant patient-reported outcome: The validation of the COmprehensive Score for financial Toxicity
Probiotics, fiber and herbal medicinal products for functional and inflammatory bowel disorders
Context processing and the neurobiology of post-traumatic stress disorder
The structure of the antibiotic deactivating,N-hydroxylating Rifampicin Monooxygenase
Mechanism of Rifampicin inactivation in Nocardia farcinica
Extensive migration of young neurons into the infant human frontal lobe
The calcium channel subunit alpha2delta2 suppresses axon regeneration in the adult CNS
Restoring mucosal barrier function and modifying macrophage phenotype with an extracellular matrix hydrogel: potential therapy for ulcerative colitis
Single-molecule imaging reveals that Rad4 employs a dynamic DNA damage recognition process
Bacterial abscess formation is controlled by the stringent stress response and can be targeted therapeutically
Spermidine suppresses age-associated memory impairment by preventing adverse increase of presynaptic active zone size and release
18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology inMAPTmutation carriers
Lack of P4H-TM in mice results in age-related retinal and renal alterations
Chemotherapy-induced IL-34 enhances immunosuppression by tumor-associated macrophages and mediates survival of chemoresistant lung cancer cells
TDP-43 stage, mixed pathologies, and clinical Alzheimers-type dementia
Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity
Autocrine BDNFTrkB signalling within a single dendritic spine
Mycoplasma pneumoniaetriggering the Guillain-Barré syndrome: A case-control study
Structure of myosin filaments from relaxed Lethocerus flight muscle by cryo-EM at 6 A resolution
Preventative vaccines for Zika virus outbreak: preliminary evaluation
Biomechanical and biochemical characterization of porcine tracheal cartilage
Stimulation-based control of dynamic brain networks
Discovery of a metastatic immune escape mechanism initiated by the loss of expression of the tumor biomarker interleukin-33
A global genetic interaction network maps a wiring diagram of cellular function
The impact of endurance training on human skeletal muscle memory, global isoform expression and novel transcripts
Preferential uptake of antioxidant carbon nanoparticles by T lymphocytes for immunomodulation
Bacteriome and mycobiome interactions underscore microbial dysbiosis in familial Crohns disease
Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin
Functional subclone profiling for prediction of treatment-induced intra-tumor population shifts and discovery of rational drug combinations in human glioblastoma
Clinical outcomes of melanoma brain metastases treated with stereotactic radiosurgery and anti-PD-1 therapy, anti-CTLA-4 therapy, BRAF/MEK inhibitors, BRAF inhibitor, or conventional chemotherapy
Leisure-time physical activity and the risk of suspected bacterial infections
Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration
Turning the fate of reprogramming cells from retinal disorder to regeneration by Pax6 in newts
Single-cell characterization of viral translation-competent reservoirs in HIV-infected individuals
Integrative modeling reveals Annexin A2-mediated epigenetic control of mesenchymal glioblastoma
Sertraline for preventing mood disorders following traumatic brain injury
Beyond Krabbe's disease: The potential contribution of galactosylceramidase deficiency to neuronal vulnerability in late-onset synucleinopathies
Bruton tyrosine kinase-dependent immune cell cross-talk drives pancreas cancer
Macrophage PI3K drives pancreatic ductal adenocarcinoma progression
PI3Kγ is a molecular switch that controls immune suppression
Effects of abaloparatide-sc on fractures and bone mineral density in subgroups of postmenopausal women with osteoporosis and varying baseline risk factors
Development of a three-dimensional bioengineering technology to generate lung tissue for personalized disease modeling
Epigenome wide association study reveals differential DNA methylation in individuals with a history of myocardial infarction
Effect of wearable technology combined with a lifestyle intervention on long-term weight loss: the IDEA randomized clinical trial
Suppressor of cytokine signaling-1 (SOCS1) peptidomimetic limits progression of diabetic nephropathy
Midlife physical activity and cognition later in life: a prospective twin study
Detection of therapeutically targetable driver and resistance mutations in lung cancer patients by next generation sequencing of cell-free circulating tumor DNA
Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling
Identification of altered metabolomic profiles following a Panchakarma-based Ayurvedic intervention in healthy subjects: the self-directed biological transformation initiative (SBTI)
Mutational signatures of ionizing radiation in second malignancies
Assessing intratumor heterogeneity and tracking longitudinal and spatial clonal evolutionary history by next-generation sequencing
Single-molecule dissection of stacking forces in DNA
Prefrontal responses to Stroop tasks in subjects with post-traumatic stress disorder assessed by functional near infrared spectroscopy
Interplay between up-regulation of cytochrome-c-oxidase and hemoglobin oxygenation induced by near-infrared laser
Synaptic mechanisms of pattern completion in the hippocampal CA3 network
On-target efficacy of a HIF2α antagonist in preclinical kidney cancer models
3D porous graphene by low-temperature plasma welding for bone implants
Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ)...
PRC2 enacts Wnt signaling in intestinal homeostasis and contributes to the instigation of stemness in diseases entailing epithelial hyperplasia or neoplasia
The orphan nuclear receptor RORα and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohns disease
Modulating neuronal competition dynamics in the dentate gyrus to rejuvenate aging memory circuits
Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein
Acquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in colorectal cancer
Gut bacteria metabolism impacts immune recovery in HIV-infected individuals
Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness
Pattern recognition with materials that compute
CRISPR-Cas9 nuclear dynamics and target recognition in living cells
Pathogenic shifts in endogenous microbiota impede tissue regeneration via distinct activation of TAK1/MKK/p38
Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies
A randomized, double-blind, placebo-controlled trial of low-dose sertraline in young children with fragile X syndrome
Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis
Low adoption of weight loss medications: A comparison of prescribing patterns of antiobesity pharmacotherapies and SGLT2s
Patient attitudes toward telemedicine for diabetic retinopathy
Recent evolution of the salivary mucin MUC7
Multi-organ mapping of cancer risk
Altered proliferation and networks in neural cells derived from idiopathic autistic individuals
Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding
Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomized, double-blind, placebo-controlled trial
Relationship between antihypertensive medications and cognitive impairment: part II. review of physiology and animal studies
Short term depression of gap junctional coupling in reticular thalamic neurons of absence epileptic rats
IL-1β is an innate immune sensor of microbial proteolysis
Genetic markers of pigmentation are novel risk loci for uveal melanoma
Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis
Cell boundary elongation by non-autonomous contractility in cell oscillation
Cellular resolution circuit mapping in mouse brain with temporal-focused excitation of soma-targeted channelrhodopsin
Complete unique genome sequence, expression profile, and salivary gland tissue tropism of the herpesvirus 7 homolog in pigtailed macaques
Biophysical insight into mechanisms of sonoporation
Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension
PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges
Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumor hypoxic regions
Targeted epigenetic remodeling of endogenous loci by CRISPR/Cas9-based transcriptional activators directly converts fibroblasts to neuronal cells
Punctuated copy number evolution and clonal stasis in triple-negative breast cancer
Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals
A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition
Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation
Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function
Risk and impact of pulmonary complications in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study
Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2 channelvesicle coupling
Neurometabolic disorders: potentially treatable abnormalities in patients with treatment-refractory depression and suicidal behavior
Stromal Hedgehog signaling is downregulated in colon cancer and its restoration restrains tumor growth
Neurons in macaque area V4 are tuned for complex spatio-temporal patterns
A conserved microRNA regulatory circuit is differentially controlled during limb/appendage regeneration
Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients
The airway microbiome at birth
Global distribution of businesses marketing stem cell-based interventions
The evolution of epigenetics: from prokaryotes to humans and its biological consequences
A dual molecular analogue tuner for dissecting protein function in mammalian cells
Olfactory receptors modulate physiological processes in human airway smooth muscle cells
OCT4 acts as an integrator of pluripotency and signal-induced differentiation
The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction
Curcumin sensitizes silymarin to exert synergistic anticancer activity in colon cancer cells
Age-dependent niche signals from the choroid plexus regulate adult neural stem cells
The macroecology of infectious diseases: a new perspective on global-scale drivers of pathogen distributions and impacts
An integrated genomic and transcriptomic survey of mucormycosis-causing fungi
A network of conserved synthetic lethal interactions for exploration of precision cancer therapy
Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity
Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity
The rhesus monkey connectome predicts disrupted functional networks resulting from pharmacogenetic inactivation of the amygdala
Spatial embedding and wiring cost constrain the functional layout of the cortical network of rodents and primates
Dysfunctional epileptic neuronal circuits and dysmorphic dendritic spines are mitigated by platelet-activating factor receptor antagonism
Comparison of ACC/AHA and ESC guideline recommendations following trial evidence for statin use in primary prevention of cardiovascular disease--results from the population-based rotterdam study
Matrix-bound nanovesicles within ECM bioscaffolds
Impact of volume change over time on trauma mortality in the United States
Intra-tumor heterogeneity affects gene expression profile test prognostic risk stratification in early breast cancer
An acellular biologic scaffold treatment for volumetric muscle loss: results of a 13-patient cohort study
ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells
Template-dependent nucleotide addition in the reverse (3'-5') direction by Thg1-like protein
Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression
Valproic acid induces antimicrobial compound production in doratomyces microspores
Automatic segmentation of Drosophila neural compartments using GAL4 expression data reveals novel visual pathways
Heart failure after myocardial infarction is associated with increased risk of cancer
In vivo bioorthogonal chemistry enables local hydrogel and systemic pro-drug to treat soft tissue sarcoma
Design of a genetically stable high fidelity coxsackievirus B3 polymerase that attenuates virus growth in vivo
Gray matter maturation and cognition in children with different APOEε genotypes
An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation
Extra-coding RNAs regulate neuronal DNA methylation dynamics
The mitochondrial unfoldase-peptidase complex ClpXP controls bioenergetics stress and metastasis
Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition
Adaptive randomization of veliparibcarboplatin treatment in breast cancer
Adaptive randomization of neratinib in early breast cancer
Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse
Pittsburgh Compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European Memory Clinic study
Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 44 million participants
DNA demethylation of inflammasome-associated genes is enhanced in patients with cryopyrin-associated periodic syndromes
Rapamycin suppresses microglial activation and reduces the development of neuropathic pain after spinal cord injury
Defining the clonal dynamics leading to mouse skin tumor initiation
Prevention of carcinogen-induced oral cancer by sulforaphane
Does the cancer risk in colonic polyps unsuitable for polypectomy support the need for advanced endoscopic resections?
Kataegis expression signature in breast cancer is associated with late onset, better prognosis, and higher HER2 levels
Identification of lesion subtypes in biopsies of ductal carcinoma in situ of the breast using biomarker ratio imaging microscopy
Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
Clinical relevance of brain atrophy assessment in multiple sclerosis. Implications for its use in a clinical routine
A powerful CRISPR/Cas9-based method for targeted transcriptional activation
Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease
Pathology of congenital Zika syndrome in Brazil: a case series
Electrical stimulation of visual cortex can immediately improve spatial vision
Machine perfusion of donor livers for transplantation: a proposal for standardized nomenclature and reporting guidelines
Longitudinal analysis of patient-reported outcomes and cosmesis in a randomized trial of conventionally fractionated versus hypofractionated whole-breast irradiation
MetaFast: fast reference-free graph-based comparison of shotgun metagenomic data
Hydroxyapatite coating on PEEK implants: biomechanical and histological study in a rabbit model
Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability
An engineered switch in T cell receptor specificity leads to an unusual but functional binding geometry
Cost-effectiveness of percutaneous closure of the left atrial appendage in atrial fibrillation based on results from PROTECT AF versus PREVAIL
Association of the extent of resection with survival in glioblastoma
Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring
Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly
Superresolution imaging reveals nanometer- and micrometer-scale spatial distributions of T-cell receptors in lymph nodes
Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic
Tumour resistance in induced pluripotent stem cells derived from naked mole-rats
Insulin-like growth factor-1 receptor deficiency in macrophages accelerates atherosclerosis and induces an unstable plaque phenotype in apolipoprotein Edeficient mice
The development of spasmolytic polypeptide/TFF2-expressing metaplasia (SPEM) during gastric repair is absent in the aged stomach
Microgeographic proteomic networks of the human colonic mucosa and their association with inflammatory bowel disease
Acrolein is a pathogenic mediator of alcoholic liver disease and the scavenger hydralazine is protective in mice
Shape transitions and chiral symmetry breaking in the energy landscape of the mitotic chromosome
Reversal of cognitive decline in Alzheimer's disease
Clinical outcomes of transplanted modified bone marrow-derived mesenchymal stem cells in stroke: a phase 1/2a study
α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinsons disease
Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomized controlled trial
Development and validation of endovascular chemotherapy filter device for removing high-dose doxorubicin: preclinical study
Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia
EGFR signal-network reconstruction demonstrates metabolic crosstalk in EMT
Human glia can both induce and rescue aspects of disease phenotype in Huntington disease
The risk of cancer with the use of recombinant human bone morphogenetic protein in spine fusion
Inflammasome-dependent induction of adaptive NK cell memory
Executive functioning and diabetes: The role of anxious arousal and inflammation
An E3-ligase-based method for ablating inhibitory synapses
Surgical therapies and tissue engineering: at the intersection between innovation and regulation
Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus
A diet mimicking fasting promotes regeneration and reduces autoimmunity and Multiple Sclerosis symptoms
Enhanced sympathetic nerve activity induced by neonatal colon inflammation induces gastric hypersensitivity and anxiety-like behavior in adult rats
Microbiota-derived phenylacetylglutamine associates with overall mortality and cardiovascular disease in patients with CKD
Dysregulation of RBFOX2 is an early event in cardiac pathogenesis of diabetes
A melanosomal two-pore sodium channel regulates pigmentation
Evidence for the role of microRNA 374b in acquired cisplatin resistance in pancreatic cancer cells
Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice
A cholesterol-based allostery model of T cell receptor phosphorylation
Zika virus infects human placental macrophages
Simultaneous scalp, skull, kidney, and pancreas transplant from a single donor
Na+ influx induced by new antimalarials causes rapid alterations in the cholesterol content and morphology of Plasmodium falciparum
A neuronal culture system to detect prion synaptotoxicity
Neuronal hyperactivity disturbs ATP microgradients, impairs microglial motility, and reduces phagocytic receptor expression triggering apoptosis/microglial phagocytosis uncoupling
Additional measurement of hCG distinguishes physiological high-normal thyroid function and reveals large differences in the risk of developing preeclampsia
Atrial arrhythmias after lung transplantation: Incidence and risk factors in 652 lung transplant recipients
A new method for preparing mesenchymal stem cells and labeling with Ferumoxytol for cell tracking by MRI
Effector T cells abrogate stroma-mediated chemoresistance in ovarian cancer
Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged ≥75 years
Combined treatment with epigenetic, differentiating, and chemotherapeutic agents cooperatively targets tumor-initiating cells in triple-negative breast cancer
Medical device approvals through the premarket approval pathway in obstetrics and gynecology from 2000 to 2015
Development of a 3D printed, bioengineered placenta model to evaluate the role of trophoblast migration in preeclampsia
Metabolic engineering of light-driven cytochrome P450 dependent pathways into Synechocystis sp. PCC 6803
The preventability of cancer: stacking the deck
Preventable incidence and mortality of carcinoma associated with lifestyle factors among white adults in the United States
A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus
Visual impairment and blindness in adults in the United States
Utilizing the dog genome in the search for novel candidate genes involved in glioma developmentgenome wide association mapping followed by targeted massive parallel sequencing identifies a strongly associated locus
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
Sitagliptin versus placebo in the treatment of nonalcoholic fatty liver disease: A randomized controlled trial
High lipoprotein(a) as a possible cause of clinical familial hypercholesterolaemia: a prospective cohort study
Greater hippocampal volume is associated with PTSD treatment response
Fc-receptor polymorphisms, cetuximab therapy, and survival in the NCIC CTG CO.17 trial of colorectal cancer
Bioengineered human acellular vessels for dialysis access in patients with end-stage renal disease: two phase 2 single-arm trials
Preliminary intraoperative validation of the nociception level index
Pharmacogenetic discovery in CALGB (Alliance) 90401 and mechanistic validation of a VAC14 polymorphism that increases risk of docetaxel-induced neuropathy
Subconcussive head trauma and near point of convergence
Association of football subconcussive head impacts with ocular near point of convergence
Nutritional supplementation to reduce child aggression: a randomized, stratified, single-blind, factorial trial
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs
Molecular mechanism of anesthetic-induced depression of myocardial contraction
Adult NG2-glia are required for median eminence-mediated leptin sensing and body weight control
Plasma biomarker analysis in pediatric ARDS: generating future framework from a pilot randomized control trial of methylprednisolone: a framework for identifying plasma biomarkers related to clinical outcomes in pediatric ARDS
Apolipoprotein E4 causes age-dependent disruption of slow gamma oscillations during hippocampal sharp-wave ripples
Simultaneous antibiofilm and antiviral activities of an engineered antimicrobial peptide during virus-bacterium coinfection
Real-time quantification of single RNA translation dynamics in living cells
DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity
Developmental acquisition of regulomes underlies innate lymphoid cell functionality
Climate change and the emergent epidemic of CKD from heat stress in rural communities: the case for heat stress nephropathy
Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein
Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
Impact of maternal glucose and gestational weight gain on child obesity over the first decade of life in normal birth weight infants
Higher C-reactive protein levels predict postoperative delirium in older patients undergoing major elective surgery: a longitudinal nested case-control study
Zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor TLR3
Rapid, low-cost detection of Zika virus using programmable biomolecular components
Defects in neuromuscular transmission may underlie motor dysfunction in spinal and bulbar muscular atrophy
Minihepcidin peptides as disease modifiers in mice affected by beta-thalassemia and polycythemia vera
Evaluation of a portable artificial vision device among patients with low vision
Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex
Mapping an index of the myelin g-ratio in infants using magnetic resonance imaging
The Clinical Research Office of the Endourological Society (CROES) multicentre randomised trial of narrow band imagingassisted transurethral resection of bladder tumour (TURBT) versus conventional white light imagingassisted TURBT in primary
Slx5/Slx8 promotes replication stress tolerance by facilitating mitotic progression
Chemical control of grafted human PSC-derived neurons in a mouse model of Parkinsons Disease
Sp7/Osterix is restricted to bone-forming vertebrates where it acts as a Dlx co-factor in osteoblast specification
Phenotypically distinct subtypes of psychosis accompany novel or rare variants in four different signaling genes
Regulators of metastasis modulate the migratory response to cell contact under spatial confinement
Factors associated with injurious falls in residential care facilities
Prioritizing variants in complete hereditary breast and ovarian cancer (HBOC) genes in patients lacking known BRCA mutations
A unified analytic framework for prioritization of non-coding variants of uncertain significance in heritable breast and ovarian cancer
Optical fiber LPG biosensor integrated microfluidic chip for ultrasensitive glucose detection
Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency
Age-dependent pancreatic gene regulation reveals mechanisms governing human β cell function
Residential radon exposure and risk of incident hematologic malignancies in the Cancer Prevention Study-II Nutrition Cohort
Tight junction protein 1 modulates proteasome capacity and proteasome inhibitor sensitivity in multiple myeloma via EGFR/JAK1/STAT3 signaling
Predictive features of ligand-specific signaling through the estrogen receptor
Interfacial geometry dictates cancer cell tumorigenicity
NAD repletion improves mitochondrial and stem cell function and enhances lifespan in mice
RNA splicing is a primary link between genetic variation and disease
Regulators of metastasis modulate the migratory response to cell contact under spatial confinement
Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model
Minimally invasive screening for colitis using attenuated total internal reflectance fourier transform infrared spectroscopy
Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV
Development and validation of a new prognostic system for patients with hepatocellular carcinoma
Fatty liver is an independent predictor of early carotid atherosclerosis
From sample to multi-omics conclusions in under 48 hours
Disentangling the association between statins, cholesterol, and colorectal cancer: a nested case-control study
Limit cycle oscillations in standing human posture
Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus
Efficient total syntheses and biological activities of two teixobactin analogues
Fracture healing: a consensus report from the International Osteoporosis Foundation Fracture Working Group
Will they participate? predicting patients response to clinical trial invitations in a pediatric emergency department
Intrauterine inflammation and maternal exposure to ambient PM2.5 during preconception and specific periods of pregnancy: the Boston birth cohort
Twist1 induces distinct cell states depending on TGFBR1-activation
Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity
Bacterial superglue enables easy development of efficient virus-like particle based vaccines
A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair
Percutaneous lymphatic embolization of abnormal pulmonary lymphatic flow as treatment of plastic bronchitis in patients with congenital heart disease clinical perspective
Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses
Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
Structural insights into the transport mechanism of the human sodium-dependent lysophosphatidylcholine transporter Mfsd2a
Magnifying smartphone screen using Google glass for low-vision users
Serum zinc concentration and C-reactive protein in individuals with human immunodeficiency virus infection: the positive living with HIV (POLH) study
The molecular basis of the genesis of basal tone in internal anal sphincter
The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression
Experimental treatment of Ebola virus disease with TKM-130803: a single-arm phase 2 clinical trial
Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells
An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
Primary prevention of cardiovascular disease in older adults
Multiscale origami structures as interface for cells
Competition between jagged-notch and endothelin1 signaling selectively restricts cartilage formation in the zebrafish upper face
Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure
Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions
Blue light reduces organ injury from ischemia and reperfusion
Genetic lineage tracing identifies endocardial origin of liver vasculature
Cholesterol analogs with degradation-resistant alkyl side chains are effective mycobacterium tuberculosis growth inhibitors
Novel 3D magnetic resonance elastography for the noninvasive diagnosis of advanced fibrosis in NAFLD: a prospective study
Population-based epidemiology and mortality of small malignant gastrointestinal stromal tumors in the USA
Epidermal growth factor suppresses intestinal epithelial cell shedding via a MAPK dependent pathway
Clinical exome sequencing in neurologic disease
Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 44 million participants
SOD-mimetic M40403 is protective in cell and fly models of paraquat toxicity: implications for Parkinson disease
Modulation of tissue repair by regeneration enhancer elements
Cortical contributions to the auditory frequency-following response revealed by MEG
Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization
X-ray structures and mechanism of the human serotonin transporter
Silicon nitride bioceramics induce chemically driven lysis in Porphyromonas gingivalis
Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
TAM receptors regulate multiple features of microglial physiology
Developing an animal model of Dupuytrens disease by orthotopic transplantation of human fibroblasts into athymic rat
Change in pain and physical function following bariatric surgery for severe obesity
Visualizing allele-specific expression in single cells reveals epigenetic mosaicism in anH19loss-of-imprinting mutant
3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: a novel class of potent tumor-selective cytotoxins
Parameter selection and verification techniques based on global sensitivity analysis illustrated for an HIV model
Role of p53, mitochondrial DNA deletions, and paternal age in autism: a case-control study
Development of the Biopen: a handheld device for surgical printing of adipose stem cells at a chondral wound site
Blocking synaptic removal of GluA2-containing AMPA receptors prevents the natural forgetting of long-term memories
Steric trapping reveals a cooperativity network in the intramembrane protease GlpG
Impact of prostate-specific antigen (PSA) screening trials and revised PSA screening guidelines on rates of prostate biopsy and postbiopsy complications
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation
Voluntary imitation in Alzheimers disease patients
Methionine and kynurenine activate oncogenic kinases in glioblastoma, and methionine deprivation compromises proliferation
Type I bHLH proteins Daughterless and Tcf4 restrict neurite branching and synapse formation by repressing neurexin in postmitotic neurons
Effective implementation of health information technologies in U.S. hospitals
Hedgehog pathway inhibition
Body temperature regulation in diabetes
Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis
Application of fluorescent protein expressing strains to evaluation of anti-tuberculosis therapeutic efficacy in vitro and in vivo
Large-scale imaging of cortical dynamics during sensory perception and behavior
Sequence features accurately predict genome-wide MeCP2 binding in vivo
Frequency and complexity of de novo structural mutation in autism
GABAergic neuron-specific loss of Ube3a causes angelman syndrome-like EEG abnormalities and enhances seizure susceptibility
Leptin controls parasympathetic wiring of the pancreas during embryonic life
Heterogeneity in Oct4 and Sox2 targets biases cell fate in 4-cell mouse embryos
Lysosomal disorders drive susceptibility to tuberculosis by compromising macrophage migration
Enhanced cancer immunotherapy by microneedle patch-assisted delivery of anti-PD1 antibody
A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy
A multicenter observational study of incretin-based drugs and heart failure
Curcumin enhances human macrophage control of Mycobacterium tuberculosis infection
Staphylococcus aureus toxin potentiates opportunistic bacterial lung infections
Primary cilium-autophagy-Nrf2 (PAN) axis activation commits human embryonic stem cells to a neuroectoderm fate
Harnessing surface-bound enzymatic reactions to organize microcapsules in solution
ECM hydrogel for the treatment of stroke: Characterization of the host cell infiltrate
Integrative single-cell transcriptomics reveals molecular networks defining neuronal maturation during postnatal neurogenesis
Gastric bypass surgery vs intensive lifestyle and medical intervention for type 2 diabetes: the CROSSROADS randomised controlled trial
Ethnicity and prevalence of multiple sclerosis in east London
Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury
Ultrasensitive antibody detection by agglutination-PCR (ADAP)
GT198 expression defines mutant tumor stroma in human breast cancer
Spinal cord stimulation (SCS) and functional magnetic resonance imaging (fMRI): modulation of cortical connectivity with therapeutic SCS
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of itaconate and to enable cytokine expression
Metagenomic sequencing with strain-level resolution implicates uropathogenic E. coli in necrotizing enterocolitis and mortality in preterm infants
Diurnal salivary cortisol patterns prior to pregnancy predict infant birth weight
Phase-selective entrainment of nonlinear oscillator ensembles
Effects of oral contraceptive use on anterior cruciate ligament injury epidemiology
Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging
Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds
Intestinal interleukin-17 receptor signaling mediates reciprocal control of the gut microbiota and autoimmune inflammation
Preoperative prealbumin level as a risk factor for surgical site infection following elective spine surgery
Mating-induced transcriptome changes in the reproductive tract of female Aedes aegypti
The effect of treatment of obstructive sleep apnea on glycemic control in type 2 diabetes
Structure- and function-based design of Plasmodium-selective proteasome inhibitors
Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis
A broad RNA virus survey reveals both miRNA dependence and functional sequestration
Declining bowel cancer incidence and mortality in Germanyan analysis of time trends in the first ten years after the introduction of screening colonoscopy
Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue
Snoo and Dpp act as spatial and temporal regulators respectively of adult progenitor cells in the Drosophila trachea
Surprising lack of liposome-induced complement activation by artificial 1,3-diamidophospholipids in vitro
Diagnostic screening for subclinical celiac disease using a rapid test in children aged 24
Individualized statin benefit for determining statin eligibility in the primary prevention of cardiovascular disease
ACEMg diet supplement modifies progression of hereditary deafness
Structural health monitoring (vibration) as a tool for identifying structural alterations of the lumbar spine: a twin control study
Drug harms in the UK: a multicriteria decision analysis
Longitudinal relationships between caloric expenditure and gray matter in the cardiovascular health study
Incidence and risk factors for food hypersensitivity in UK infants: results from a birth cohort study
Weekly vs. every-3-week paclitaxel and carboplatin for ovarian cancer
Structural hot spots for the solubility of globular proteins
NF-κB restricts inflammasome activation via elimination of damaged mitochondria
Functional segregation of cortical regions underlying speech timing and articulation
Age-dependent decrease of mitochondrial complex II activity in human skin fibroblasts
Bariatric surgery and emergency department visits and hospitalizations for heart failure exacerbation
Perineural expression of high-mobility group box-1 contributes to long-lasting mechanical hypersensitivity via matrix metalloprotease-9 up-regulation in mice with painful peripheral neuropathy
Hypothalamic leptin action is mediated by histone deacetylase 5
Targeting p38 or MK2 enhances the anti-leukemic activity of smac-mimetics
Down syndrome developmental brain transcriptome reveals defective oligodendrocyte differentiation and myelination
-specific PCR for diagnosis and therapeutic guidance for symptomatic Neoehrlichiosis in immunocompetent host
Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer
Prognostic impact of modulators of G proteins in circulating tumor cells from patients with metastatic colorectal cancer
Skin redox balance maintenance: the need for an Nrf2-activator delivery system
Constitutive modeling of ascending thoracic aortic aneurysms using microstructural parameters
Distinct structural pathways coordinate the activation of AMPA receptor-auxiliary subunit complexes
Association between objectively measured physical activity and mortality in NHANES
The BENEFIT trial: where do we go from here?
Strong components of epigenetic memory in cultured human fibroblasts related to site of origin and donor age
Positional proteomics reveals differences in N-terminal proteoform stability
Structural and molecular basis for Ebola virus neutralization by protective human antibodies
Protective monotherapy against lethal Ebola virus infection by a potent neutralizing antibody
Metabolomics-based discovery of small molecule biomarkers in serum associated with dengue virus infections and disease outcomes
Complete meiosis from embryonic stem cell-derived germ cells in vitro
Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum
Self-induced switchings between multiple spacetime patterns on complex networks of excitable units
A 3D bioprinting system to produce human-scale tissue constructs with structural integrity
Convective flow reversal in self-powered enzyme micropumps
The third international consensus definitions for sepsis and septic shock (sepsis-3)
A framework for the development and interpretation of different sepsis definitions and clinical criteria
Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress syndrome
Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress syndrome
Dental pulp stem cells: a new cellular resource for corneal stromal regeneration
Monodispersed calcium carbonate nanoparticles modulate local pH and inhibit tumor growth in vivo
RNA hairpin folding in the crowded cell
Correlated magnetic resonance imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis
The role of risk-reducing surgery in hereditary breast and ovarian cancer
Effect of acetazolamide vs placebo on duration of invasive mechanical ventilation among patients with chronic obstructive pulmonary disease: a randomized clinical trial
Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity
Chronic ampakine treatments stimulate dendritic growth and promote learning in middle-aged rats
Intracellular mGluR5 plays a critical role in neuropathic pain
Collagen and heparan sulfate coatings differentially alter cell proliferation and attachment in vitro and in vivo
MLL1 is essential for the senescence-associated secretory phenotype
Rapid dry-reagent immunomagnetic biosensing platform based on volumetric detection of nanoparticles on 3D structures
The kinetochore prevents centromere-proximal crossover recombination during meiosis
Divergent associations of height with cardiometabolic disease and cancer: epidemiology, pathophysiology, and global implications
Innate lymphoid cells are depleted irreversibly during acute HIV-1 infection in the absence of viral suppression
Are the symptoms of calcific tendinitis due to neoinnervation and/or neovascularization?
The root extract of the medicinal plant Pelargonium sidoides is a potent HIV-1 attachment inhibitor
Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins
Principles governing the self-assembly of coiled-coil protein nanoparticles
5-azacytidine enhances the mutagenesis of HIV-1 by reduction to 5-aza-2-deoxycytidine
Endomucin prevents leukocyteendothelial cell adhesion and has a critical role under resting and inflammatory conditions
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism
Functional malignant cell heterogeneity in pancreatic neuroendocrine tumors revealed by targeting of PDGF-DD
Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1
Acute changes in striatal microstructure predict the development of interferon-alpha induced fatigue
Highly robust crystalsome via directed polymer crystallization at curved liquid/liquid interface
SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex
Anthropogenic radio-frequency electromagnetic fields elicit neuropathic pain in an amputation model
Neural bases of orthographic long-term memory and working memory in dysgraphia
Understanding the association between chronic obstructive pulmonary disease and current anxiety: a population-based study
Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival
Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
On-chip construction of liver lobule-like microtissue and its application for adverse drug reaction assay
Non-catalytic roles for XPG with BRCA1 and BRCA2 in homologous recombination and genome stability
Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain
Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the copper-chaperone-for-SOD
Sustained Akt activity is required to maintain cell viability in seborrheic keratosis, a benign epithelial tumor
Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells
Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells
Life span extension by targeting a link between metabolism and histone acetylation in Drosophila
Post-translational control of the temporal dynamics of transcription factor activity regulates neurogenesis
High-resolution wavefront shaping with a photonic crystal fiber for multimode fiber imaging
Novel Wnt regulator NEL-like molecule-1 antagonizes adipogenesis and augments osteogenesis induced by bone morphogenetic protein 2
Safety and efficacy of plasmid DNA expressing two isoforms of hepatocyte growth factor in patients with critical limb ischemia
Differential toxicity of antibodies to the prion protein
Trim28 haploinsufficiency triggers bi-stable epigenetic obesity
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans
Spontaneous decoding of the timing and content of human object perception from cortical surface recordings reveals complementary information in the event-related potential and broadband spectral change
Lipofilling of the breast does not increase the risk of recurrence of breast cancer
An unprecedented mechanism of nucleotide methylation in organisms containing thyX
Cell-type-specific control of brainstem locomotor circuits by basal ganglia
Pathway-specific remodeling of thalamostriatal synapses in Parkinsonian mice
Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2
DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
Computational modeling of oscillating fins that catch and release targeted nanoparticles in bilayer flows
Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response
Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation
Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression ofCdkn2a
Predicting the risk of malignancy in adnexal masses based on the Simple Rules from the International Ovarian Tumor Analysis (IOTA) group
Transcriptomic analysis of the host response and innate resilience to enterotoxigenic Escherichia coli infection in humans
Bone microarchitecture in men and women with diabetes: the importance of cortical porosity
Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes
Association of asymptomatic bradycardia with incident cardiovascular disease and mortality: the multi-ethnic study of atherosclerosis (MESA)
Plug-and-display: decoration of virus-like particles via isopeptide bonds for modular immunization
Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2
Lactoferrin acts as an adjuvant during influenza vaccination of neonatal mice
Vitamin B12 status in older adults living in Ontario long-term care homes: prevalence and incidence of deficiency with supplementation as a protective factor
COMT and OPRM1 genotype associations with daily knee pain variability and activity induced pain
Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc
Sustained correction of FVII deficiency in dogs using AAV-mediated expression of zymogen FVII
Bioresorbable silicon electronic sensors for the brain
Functional genomic landscape of human breast cancer drivers, vulnerabilities, and resistance
Functionalization of C(sp3)-H bonds using a transient directing group
Reconfigurable chiroptical nanocomposites with chirality transfer from the macro- to the nanoscale
Lysyl oxidase is associated with increased thrombosis and platelet reactivity
WNT-SHH antagonism specifies and expands stem cells prior to niche formation
Bicarbonate concentration, acid-base status, and mortality in the health, aging, and body composition study
Local and global consequences of flow on bacterial quorum sensing
High Kellgren-Lawrence grade and bone marrow lesions predict worsening rates of radiographic joint space narrowing; the SEKOIA study
Obesity-induced colorectal cancer is driven by caloric silencing of the guanylin-GUCY2C paracrine signaling axis
TNF drives monocyte dysfunction with age and results in impaired anti-pneumococcal immunity
Fiber and saturated fat are associated with sleep arousals and slow wave sleep
Astrocytes assemble thalamocortical synapses by bridging NRX1α and NL1 via hevin
AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
Functional reorganization and prediction of motor recovery after a stroke: A graph theoretical analysis of functional networks
Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells
Objectively-measured sedentary time and cardiometabolic health in adults with severe obesity
Shared genetic predisposition in peripartum and dilated cardiomyopathies
Secreted factors from human vestibular schwannomas can cause cochlear damage
Proxy measures of vitamin D status season and latitude correlate with adverse outcomes after bariatric surgery in the Nationwide Inpatient Sample, 20012010: a retrospective cohort study
Prevention of premature menopause and preservation of fertility in young cancer survivors: hopeful though modest long-term results
Ovarian suppression with triptorelin during adjuvant breast cancer chemotherapy and long-term ovarian function, pregnancies, and disease-free survival: a randomized clinical trial
Transient acute kidney injury in the postoperative period: it is time to pay closer attention
Cardiovascular-specific mortality and kidney disease in patients undergoing vascular surgery
In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity
YAP is a critical inducer of SOCS3, preventing reactive astrogliosis
Organic and inorganic mercurials have distinct effects on cellular thiols, metal homeostasis, and Fe-binding proteins in Escherichia coli
Visualization of bacterial microcompartment facet assembly using high-speed atomic force microscopy
Warning symptoms are associated with survival from sudden cardiac arrest
In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer
Abnormal cell-intrinsic and network excitability in the neocortex of serotonin-deficient Pet-1 knock-out mice
Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA
In vivo single-particle imaging of nuclear mRNA export in budding yeast demonstrates an essential role for Mex67p
Patterns and functional implications of rare germline variants across 12 cancer types
Toll-like receptor 4mediated lymphocyte influx induces neonatal necrotizing enterocolitis
Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles
Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy
Aerobic fitness in late adolescence and the risk of early death: a prospective cohort study of 1.3 million Swedish men
Extreme vulnerability of IDH1 mutant cancers to NAD+ depletion
Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins
A fully human antibody to gp41 selectively eliminates HIV-infected cells that transmigrated across a model human blood brain barrier
SerpinB1 promotes pancreatic β cell proliferation
Electronic enhancement of tear secretion
Analytic models of oxygen and nutrient diffusion, metabolism dynamics, and architecture optimization in three-dimensional tissue constructs with applications and insights in cerebral organoids
Long-term outcome of a phase II trial using immunomodulatory in situ gene therapy in combination with intensity-modulated radiotherapy with or without hormonal therapy in the treatment of prostate cancer
Dnmt3a2: a hub for enhancing cognitive functions
Skeletal muscle and pediatric bone development
A cellular system for spatial signal decoding in chemical gradients
Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis
A human 3′UTR clone collection to study post-transcriptional gene regulation
Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target
The human pancreas as a source of protolerogenic extracellular matrix scaffold for a new-generation bioartificial endocrine pancreas
Valsartan/Sacubitril for heart failure reconciling disparities between preclinical and clinical investigations
Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR
Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis
Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment
Neuropathic ocular pain due to dry eye is associated with multiple comorbid chronic pain syndromes
Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5
Subtle CXCR3-dependent chemotaxis of CTLs within infected tissue allows efficient target localization
Oxygen enhanced MRI accurately identifies, quantifies, and maps hypoxia in preclinical cancer models
Re-opening the critical window for estrogen therapy
Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance
Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse
PTH induces systemically administered mesenchymal stem cells to migrate to and regenerate spine injuries
Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques
Delayed rod-mediated dark adaptation is a functional biomarker for incident early age-related macular degeneration
Detection of aberrant hippocampal mossy fiber connections: Ex vivo mesoscale diffusion MRI and microtractography with histological validation in a patient with uncontrolled temporal lobe epilepsy
Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division
AAV gene transfer delays disease onset in a TPP1-deficient canine model of the late infantile form of Batten disease
Simultaneous reprogramming and gene correction of patient fibroblasts
Human induced pluripotent stem cellderived podocytes mature into vascularized glomeruli upon experimental transplantation
rAAV-CFTRΔR rescues the cystic fibrosis phenotype in human intestinal organoids and CF mice
Panretinal photocoagulation vs intravitreous ranibizumab for proliferative diabetic retinopathy
The bioenergetic costs of a gene
C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation
Cell typespecific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors
Self-assembled 20-nm 64Cu-micelles enhance accumulation in rat glioblastoma
Super natural killer cells that target metastases in the tumor draining lymph nodes
Red blood cell dysfunction induced by high-fat diet
Combining suppression of stemness with lineage-specific induction leads to conversion of pluripotent cells into functional neurons
Prediction of drug-induced nephrotoxicity and injury mechanisms with human induced pluripotent stem cell-derived cells and machine learning methods
Transcriptional landscape of cardiomyocyte maturation
Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution
Harnessing cellular-derived forces in self-assembled microtissues to control the synthesis and alignment of ECM
Structural stability and local dynamics in disease-causing mutants of human apolipoprotein A-I: what makes the protein amyloidogenic?
MicroRNA expression profiling of human blood monocyte subsets highlights functional differences
RNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics
Mining retrospective data for virtual prospective drug repurposing: L-DOPA and age-related macular degeneration
Unproven stem cellbased interventions and achieving a compromise policy among the multiple stakeholders
A 3′ poly(A) tract is required for LINE-1 retrotransposition
Dynamics of cell generation and turnover in the human heart
No evidence for cardiomyocyte number expansion in preadolescent mice
Modeling of autosomal-dominant retinitis pigmentosa in Caenorhabditis elegans uncovers a nexus between global impaired functioning of certain splicing factors and cell type-specific apoptosis
Inhibition of cyclooxygenase-2 in hematopoietic cells results in salt-sensitive hypertension
Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress
Iroquois proteins promote skeletal joint formation by maintaining chondrocytes in an immature state
Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells
GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions
A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence
Rare variants in cardiomyopathy genes associated with stress-induced cardiomyopathy
Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly
Identifying an ovarian cancer cell hierarchy regulated by bone morphogenetic protein 2
Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7
Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line
De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies
Ultrasound ablation enhances drug accumulation and survival in mammary carcinoma models
HIP1 is an early-stage prognostic biomarker of lung adenocarcinoma and suppresses metastasis via Akt-mediated EMT
Efficient test and visualization of multi-set intersections
Multiscale embedded gene co-expression network analysis
Hydrogels with tunable stress relaxation regulate stem cell fate and activity
Multinucleated giant cells are specialized for complement-mediated phagocytosis and large target destruction
Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial
Stimuli-responsive behavior of composites integrating thermo-responsive gels with photo-responsive fibers
Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis
A versatile microarray platform for capturing rare cells
Long-term culture and expansion of primary human hepatocytes
CDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation
Dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity
The molecular karyotype of 25 clinical-grade human embryonic stem cell lines
Human umbilical tissue-derived cells promote synapse formation and neurite outgrowth via thrombospondin family proteins
Acquisition of portal venous circulating tumor cells from patients with pancreaticobiliary cancers by endoscopic ultrasound
Intravenous multipotent adult progenitor cell treatment decreases inflammation leading to functional recovery following spinal cord injury
Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade
Chemical modifications mark alternatively spliced and uncapped messenger RNAs in arabidopsis
New approaches to biological pacemakers: links to sinoatrial node development
Spontaneous activity of cochlear hair cells triggered by fluid secretion mechanism in adjacent support cells
Small cell lung cancer: recruitment of macrophages by circulating tumor cells
Type 1 diabetes immunotherapy using polyclonal regulatory T cells
Nucleosome stability distinguishes two different promoter types at all protein-coding genes in yeast
New details of the human corneal limbus revealed with second harmonic generation imaging
Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction
The interferon-induced transmembrane proteins, IFITM1, IFITM2, and IFITM3 inhibit hepatitis C virus entry
Perforin-positive dendritic cells exhibit an immuno-regulatory role in metabolic syndrome and autoimmunity
Distinct routes of lineage development reshape the human blood hierarchy across ontogeny
Advanced cell therapies: targeting, tracking and actuation of cells with magnetic particles
Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling
Invasive cell fate requires G1 cell-cycle arrest and histone deacetylase-mediated changes in gene expression
The ecology of the microbiome: Networks, competition, and stability
Noninvasive tracking of gene transcript and neuroprotection after gene therapy
Cell-selective arrhythmia ablation for photomodulation of heart rhythm
Lanosterol reverses protein aggregation in cataracts
Pharmacological chaperone for α-crystallin partially restores transparency in cataract models
A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs
Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder
Pericytes are progenitors for coronary artery smooth muscle
Atypical PKC-iota controls stem cell expansion via regulation of the Notch pathway
Comparison of human embryonic stem cell-derived cardiomyocytes, cardiovascular progenitors, and bone marrow mononuclear cells for cardiac repair
SoxC transcription factors are essential for the development of the inner ear
Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss
A pleiotropic RNA-binding protein controls distinct cell cycle checkpoints to drive resistance of p53-defective tumors to chemotherapy
Safe and bodywide muscle transduction in young adult Duchenne muscular dystrophy dogs with adeno-associated virus
RNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics
A lab-in-a-briefcase for rapid prostate specific antigen (PSA) screening from whole blood
Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids
Regeneration of thyroid function by transplantation of differentiated pluripotent stem cells
Carcinogenic parasite secretes growth factor that accelerates wound healing and potentially promotes neoplasia
The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes
Patrolling monocytes control tumor metastasis to the lung
Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma
Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic Lupus Erythematosus mice and humans
MSC transplantation improves osteopenia via epigenetic regulation of notch signaling in Lupus
Designing synthetic microcapsules that undergo biomimetic communication and autonomous motion
Arsenic promotes NF-κB-mediated fibroblast dysfunction and matrix remodeling to impair muscle stem cell function
Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs
Genetic sharing and heritability of paediatric age of onset autoimmune diseases
Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation
Particle dynamics and deposition in true-scale pulmonary acinar models
The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis
Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease
Clusterin seals the ocular surface barrier in mouse dry eye
The protein complex of neurodegeneration-related phosphoinositide phosphatase Sac3 and ArPIKfyve binds the Lewy-body-associated Synphilin-1 preventing its aggregation
Anesthesia-induced neuronal apoptosis in the developing retina: a window of opportunity
Oct1 and OCA-B are selectively required for CD4 memory T cell function
Practical experience of the application of a weighted burden test to whole exome sequence data for obesity and schizophrenia
Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 G93A mouse model of amyotrophic lateral sclerosis
Agonist antibody that induces human malignant cells to kill one another
Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality
Nephron organoids derived from human pluripotent stem cells model kidney development and injury
Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels
Is higher serum cholesterol associated with altered tendon structure or tendon pain? A systematic review
Identification and characterization of essential genes in the human genome
Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions
A basal stem cell signature identifies aggressive prostate cancer phenotypes
Neural stem cells rescue cognitive and motor dysfunction in a transgenic model of dementia with Lewy Bodies through a BDNF-dependent mechanism
An epigenetic pathway regulates sensitivity of breast cancer cells to HER2 inhibition via FOXO/c-Myc axis
Sleep disruption impairs haematopoietic stem cell transplantation in mice
A skin-inspired organic digital mechanoreceptor
Direct tumor recognition by a human CD4+ T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses
Myeloid dysregulation in a human induced pluripotent stem cell model of PTPN11-associated juvenile myelomonocytic leukemia
Blood-derived CD4 T cells naturally resist pyroptosis during abortive HIV-1 infection
Lack of neuronal IFN-β-IFNAR causes Lewy body- and Parkinsons Disease-like dementia
Partial loss of Rpl11 in adult mice recapitulates Diamond-Blackfan anemia and promotes lymphomagenesis
Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo
Galectin-1 prevents infection and damage induced by Trypanosoma cruzi on cardiac cells
Long-term outcome of patients with AL amyloidosis treated with high-dose melphalan and stem-cell transplantation
Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects
PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer
Childhood to early-midlife systolic blood pressure trajectories: early-life predictors, effect modifiers, and adult cardiovascular outcomes
Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice
Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP, TGFβ and Wnt signaling
A modular, DNA-based beacon for single-step fluorescence detection of antibodies and other proteins
Disruption of histone methylation in developing sperm impairs offspring health transgenerationally
An aminopeptidase in the Drosophila testicular niche acts in germline stem cell maintenance and spermatogonial dedifferentiation
Antioxidants can increase melanoma metastasis in mice
In vitro screen of a small molecule inhibitor drug library identifies multiple compounds that synergize with oncolytic myxoma virus against human brain tumor-initiating cells
Reconstruction and simulation of neocortical microcircuitry
Poroelastic foams for simple fabrication of complex soft robots
Plasticity-driven individualization of olfactory coding in mushroom body output neurons
A metabolome-wide association study of kidney function and disease in the general population
Functional classification of memory CD8+ T cells by CX3CR1 expression
Relationship between morphological and cytogenetic heterogeneity in invasive micropapillary carcinoma of the breast: a report of one case
Ratios of T-cell immune effectors and checkpoint molecules as prognostic biomarkers in diffuse large B-cell lymphoma: a population-based study
Human α7 integrin gene (ITGA7) delivered by adeno-associated virus extends survival of severely affected dystrophin/utrophin-deficient mice
Human endogenous retrovirus-K contributes to motor neuron disease
Structural basis for gene regulation by a B12-dependent photoreceptor
LRP2 acts as SHH clearance receptor to protect the retinal margin from mitogenic stimuli
SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef
HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation
A novel locus of resistance to severe malaria in a region of ancient balancing selection
Multiple repressive mechanisms in the hippocampus during memory formation
Mondo-Mlx mediates organismal sugar sensing through the gli-similar transcription factor Sugarbabe
Arrhythmogenic effects of mutated L-type Ca2+-channels on an optogenetically paced muscular pump in Caenorhabditis elegans
SiRHoechst is a far-red DNA stain for live-cell nanoscopy
Single cell RNA-sequencing of pluripotent states unlocks modular transcriptional variation
Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis
Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals
Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination
Excision of unstable artificial gene-specific inverted repeats mediates scar-free gene deletions in Escherichia coli
MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells
Human satellite cell transplantation and regeneration from diverse skeletal muscles
Remote control of therapeutic T cells through a small moleculegated chimeric receptor
Arterial blood, rather than venous blood, is a better source for circulating melanoma cells
Neurogenin 3 expressing cells in the human exocrine pancreas have the capacity for endocrine cell fate
Human pluripotent stem cell-derived neural constructs for predicting neural toxicity
Insulin demand regulates β cell number via the unfolded protein response
Hyaluronic acid-serum hydrogels rapidly restore metabolism of encapsulated stem cells and promote engraftment
Harnessing the multifunctionality in nature: a bioactive agent release system with self-antimicrobial and immunomodulatory properties
Systematic identification of factors for provirus silencing in embryonic stem cells
Three different pathways prevent chromosome segregation in the presence of DNA damage or replication stress in budding yeast
High mitochondrial respiration and glycolytic capacity represent a metabolic phenotype of human tolerogenic dendritic cells
Neuronal differentiation of human mesenchymal stem cells using exosomes derived from differentiating neuronal cells
Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans
MYC disrupts the circadian clock and metabolism in cancer cells
Co-culturing Escherichia coli O157:H7 with a non-pathogenic E. coli strain increases toxin production and virulence in a germ-free mouse model
The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development
Control of stochastic and induced switching in biophysical networks
Association between vitamin D status and age-related macular degeneration by genetic risk
Joint associations of diet, lifestyle, and genes with age-related macular degeneration
Frequent derepression of the mesenchymal transcription factor gene FOXC1 in acute myeloid leukemia
Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial
Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation
GITR subverts Foxp3+ Tregs to boost Th9 immunity through regulation of histone acetylation
Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats
Kinome-wide decoding of network-attacking mutations rewiring cancer signaling
Unmasking determinants of specificity in the human kinome
Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response
Single-cell in situ RNA profiling by sequential hybridization
Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons
Direct conversion of normal and Alzheimers disease human fibroblasts into neuronal cells by small molecules
Programmed synthesis of three-dimensional tissues
Nerve growth factor gene therapy--activation of neuronal responses in Alzheimer disease
Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
Sidekick 2 directs formation of a retinal circuit that detects differential motion
Restoration of vision with ectopic expression of human rod opsin
Peripheral lesions identified on ultrawide field imaging predict increased risk of diabetic retinopathy progression over 4 years
Rapid 3D extrusion of synthetic tumor microenvironments
Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics
Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death
Characterizing the DNA damage response by cell tracking algorithms and cell features classification using high-content time-lapse analysis
CD47 blockade triggers T cellmediated destruction of immunogenic tumors
Dally proteoglycan mediates the autonomous and nonautonomous effects on tissue growth caused by activation of the PI3K and TOR pathways
Fetal microchimerism and maternal health: A review and evolutionary analysis of cooperation and conflict beyond the womb
Polyol-silk bioink formulations as two-part room-temperature curable materials for 3D printing
SpDamID: Marking DNA bound by protein complexes identifies Notch-dimer responsive enhancers
Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis
Disease-associated single-nucleotide polymorphisms from noncoding regions in juvenile idiopathic arthritis are located within or adjacent to functional genomic elements of human neutrophils and CD4+ T cells
Adipose tissue-derived mesenchymal stromal cells protect mice infected with Trypanosoma cruzi from cardiac damage through modulation of anti-parasite immunity
IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis
Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer
Prostate sphere-forming stem cells are derived from the P63-expressing basal compartment
Type 2 fibroblast growth factor receptor signaling preserves stemness and prevents differentiation of prostate stem cells from the basal compartment
DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts
Distinct EMT programs control normal mammary stem cells and tumour-initiating cells
Polarized E-cadherin endocytosis directs actomyosin remodeling during embryonic wound repair
PE and PS lipids synergistically enhance membrane poration by a peptide with anticancer properties
Gene therapy fully restores vision to the all-cone Nrl−/−Gucy2e−/− mouse model of Leber Congenital Amaurosis-1
Exome sequencing analysis reveals variants in primary immunodeficiency genes in patients with very early onset inflammatory bowel disease
Platform technology for scalable assembly of instantaneously functional mosaic tissues
Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
Materials advances for next-generation ingestible electronic medical devices
Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord
Oscope identifies oscillatory genes in unsynchronized single-cell RNA-seq experiments
Elevated mitochondrial bioenergetics and axonal arborization size are key contributors to the vulnerability of dopamine neurons
Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity
Role of tumor pericytes in the recruitment of myeloid-derived suppressor cells
DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts
Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses
Dipeptide species regulate p38MAPKSmad3 signalling to maintain chronic myelogenous leukaemia stem cells
Cell-to-cell transmission of HIV-1 is required to trigger pyroptotic death of lymphoid-tissue-derived CD4 T cells
Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
Robust anti-viral immunity requires multiple distinct T cell-dendritic cell interactions
Association between vitamin D status and age-related macular degeneration by genetic risk
Clinical actionability of multigene panel testing for hereditary breast and ovarian cancer risk assessment
Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc−, the Na+-independent glutamatecystine exchanger
Preparation and characterisation of antibacterial silver-containing nanofibres for wound healing in diabetic mice
A gene-based association method for mapping traits using reference transcriptome data
Unjamming and cell shape in the asthmatic airway epithelium
Designing synthetic microcapsules that undergo biomimetic communication and autonomous motion
Characterization of a steroid receptor coactivator small molecule stimulator that overstimulates cancer cells and leads to cell stress and death
Real-time imaging reveals local, transient vascular permeability, and tumor cell intravasation stimulated by TIE2hi macrophagederived VEGFA
Complete biosynthesis of opioids in yeast
Pancreatic cancer metastases harbor evidence of polyclonality
AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer
Humanized mice reveal differential immunogenicity of cells derived from autologous induced pluripotent stem cells
Microbiota-dependent activation of an autoreactive T cell receptor provokes autoimmunity in an immunologically privileged site
Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells
Enhanced efficiency of genetic programming toward cardiomyocyte creation through topographical cues
Retinal angiogenesis effects of TGF-ß1, and paracrine factors secreted from human placental stem cells in response to a pathological environment
Exercise training causes differential changes in gene expression in diaphragm arteries and 2A arterioles of obese rats
LINE-1 expression and retrotransposition in Barretts esophagus and esophageal carcinoma
Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma
Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution
Matrix-metalloproteinase-9 is cleaved and activated by Cathepsin K
A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation
Cell typespecific manipulation with GFP-dependent Cre recombinase
Coacervate delivery of growth factors combined with a degradable hydrogel preserves heart function after myocardial infarction
Differential connexin function enhances self-renewal in glioblastoma
Embryonic stem cells license a high level of dormant origins to protect the genome against replication stress
Fate of distal lung epithelium cultured in a decellularized lung extracellular matrix
Commissural axonal corridors instruct neuronal migration in the mouse spinal cord
A hyaluronan-based injectable hydrogel improves the survival and integration of stem cell progeny following transplantation
Clonal deletion prunes but does not eliminate self-specific αβ CD8+ T lymphocytes
Advances in reprogramming-based study of neurologic disorders
Plasticity of the human visual system after retinal gene therapy in patients with Lebers congenital amaurosis
Metabolic rescue in pluripotent cells from patients with mtDNA disease
A multimaterial bioink method for 3D printing tunable, cell-compatible hydrogels
Three-dimensional printing of high-content graphene scaffolds for electronic and biomedical applications
FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders
The carbonic anhydrase inhibitor ethoxzolamide inhibits the mycobacterium tuberculosis PhoPR Regulon and Esx-1 secretion and attenuates virulence
Changes in genetic risk for emotional eating across the menstrual cycle: a longitudinal study
Single-cell migration chip for chemotaxis-based microfluidic selection of heterogeneous cell populations
NY-ESO-1specific TCRengineered T cells mediate sustained antigen-specific antitumor effects in myeloma
Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury
A microfluidic device for label-free, physical capture of circulating tumor cell clusters
The mouse brain metabolome: region-specific signatures and response to excitotoxic neuronal injury
PDGFB-based stem cell gene therapy increases bone strength in the mouse
Near-infrared emitting and pro-angiogenic electrospun conjugated polymer scaffold for optical biomaterial tracking
Cell therapy using human induced pluripotent stem cell-derived renal progenitors ameliorates acute kidney injury in mice
Adoptive transfer of activated marrow-infiltrating lymphocytes induces measurable antitumor immunity in the bone marrow in multiple myeloma
Reinforcement of hydrogels using three-dimensionally printed microfibers
Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates
Telomerase abrogates aneuploidy‐induced telomere replication stress, senescence and cell depletion
In vivo single-cell labeling by confined primed conversion
The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes
Vibrational imaging of glucose uptake activity in live cells and tissues by stimulated Raman scattering
Low-dose irradiation enhances gene targeting in human pluripotent stem cells
TLR-2 signaling promotes IL-17A production in CD4+CD25+Foxp3+ regulatory cells during oropharyngeal candidiasis
Kinetics of CO2 exchange with carbonic anhydrase immobilized on fiber membranes in artificial lungs
Acidic sweep gas with carbonic anhydrase coated hollow fiber membranes synergistically accelerates CO2 removal from blood
Endothelial NO-synthase gene-enhanced progenitor cell therapy for Pulmonary Arterial Hypertension: the PHACeT trial
Inducing stem cell myogenesis using NanoScript
Co-option of membrane wounding enables virus penetration into cells
Preconditioning allows engraftment of mouse and human embryonic lung cells, enabling lung repair in mice
The genetic landscape of hematopoietic stem cell frequency in mice
CNTF gene therapy confers lifelong neuroprotection in a mouse model of human retinitis pigmentosa
Metabolic rescue in pluripotent cells from patients with mtDNA disease
Retinoic acid differentially regulates the migration of innate lymphoid cell subsets to the gut
Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming
Loss of α(E)-catenin promotes Fas mediated apoptosis in tubular epithelial cells
Positively charged oligo[poly(ethylene glycol) fumarate] scaffold implantation results in a permissive lesion environment after spinal cord injury in rat
Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance
An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes
Targeting the microRNA passenger strand for regulating therapeutic transgenes
Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo
Recurrent fusion genes in gastric cancer: CLDN18-ARHGAP26 induces loss of epithelial integrity
Novel protein Callipygian defines the back of migrating cells
Infusion of human bone marrow-derived mesenchymal stem cells alleviates autoimmune nephritis in a lupus model by suppressing follicular helper T cell development
Spraying respiratory epithelial cells to coat tissue-engineered constructs
Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus
Long-lived plasma cells are contained within the CD19−CD38hiCD138+ subset in human bone marrow
Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion
Kinetochore-localized PP1Sds22 couples chromosome segregation to polar relaxation
Atomic goldenabled three-dimensional lithography for silicon mesostructures
Ets factors regulate neural stem cell depletion and gliogenesis in Ras pathway glioma
Therapeutic effects of glatiramer acetate and grafted CD115+ monocytes in a mouse model of Alzheimers disease
Mobile element insertions are frequent in oesophageal adenocarcinomas and can mislead paired-end sequencing analysis
Self-organizing human cardiac microchambers mediated by geometric confinement
Lymphatic vessels arise from specialized angioblasts within a venous niche
Distinct transcriptional programs underlie Sox9 regulation of the mammalian chondrocyte
Digital microfluidic immunocytochemistry in single cells
Quantification of retinogenesis in 3D cultures reveals epigenetic memory and higher efficiency in iPSCs derived from rod photoreceptors
Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves
Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression
Somatic mutations and clonal hematopoiesis in aplastic anemia
Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration
Are migraineurs naturally born well-hearted?
Nanotubes mediate nichestem-cell signalling in the Drosophila testis
Trophic effects of dental pulp stem cells on Schwann cells in peripheral nerve regeneration
Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells
Concentration- and chromosome-organization-dependent regulator unbinding from DNA for transcription regulation in living cells
Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome
Autoantibody-targeted treatments for acute exacerbations of idiopathic pulmonary fibrosis
A highly elastic and rapidly crosslinkable elastin-like polypeptide-based hydrogel for biomedical applications
A highly elastic and rapidly crosslinkable elastin-like polypeptide-based hydrogel for biomedical applications
Genetic analysis for a shared biological basis between migraine and coronary artery disease
Quantification of retinogenesis in 3D cultures reveals epigenetic memory and higher efficiency in iPSCs derived from rod photoreceptors
Broad anti-tumor activity of a small molecule that selectively targets the Warburg Effect and lipogenesis
Determination of the action spectrum of UVR-induced mitochondrial DNA damage in human skin cells
High IFN-γ and low SLPI mark severe asthma in mice and humans
Cell-cell communication in yeast using auxin biosynthesis and auxin responsive CRISPR transcription factors
Bivalent separation into univalents precedes age-related meiosis I errors in oocytes
Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression
HIV-specific immunity derived from chimeric antigen receptor-engineered stem cells
Magnetic levitation of single cells
Decay in survival motor neuron and plastin 3 levels during differentiation of iPSC-derived human motor neurons
T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection
MicroRNA-132 enhances transition from inflammation to proliferation during wound healing
A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort
Histone demethylases KDM4A and KDM4C regulate differentiation of embryonic stem cells to endothelial cells
MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging
Skipped-stimulus approach reveals that short-term plasticity dominates synaptic strength during ongoing activity
Three-year outcomes of bariatric surgery vs lifestyle intervention for type 2 diabetes mellitus treatment: a randomized clinical trial
Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy
Selective susceptibility of human skin antigen presenting cells to productive dengue virus infection
Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5+ stem cells
Cell death during crisis is mediated by mitotic telomere deprotection
Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization
Xenogeneic mesenchymal stromal cells improve wound healing and modulate the immune response in an extensive burn model
Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model
Quiescence of memory CD8 T cells is mediated by regulatory T cells through inhibitory receptor CTLA-4
Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus
Autologous olfactory lamina propria transplantation for chronic spinal cord injury: three-year follow-up outcomes from a prospective double blinded clinical trial
Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells
PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles
Krt19+/Lgr5−cells are radioresistant cancer-initiating stem cells in the colon and intestine
Preclinical and clinical evidence of mycobacterium tuberculosis persistence in the hypoxic niche of bone marrow mesenchymal stem cells after therapy
In vivo quantification of cochlin in glaucomatous DBA/2J mice using optical coherence tomography
DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis
SIV encephalitis lesions are composed of CD163+ macrophages present in the central nervous system during early SIV infection and SIV-positive macrophages recruited terminally with AIDS
Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation
Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal
ATM couples replication stress and metabolic reprogramming during cellular senescence
Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening
Siglec receptors impact mammalian lifespan by modulating oxidative stress
Massively parallel delivery of large cargo into mammalian cells with light pulses
Analysis of loss-of-function variants and 20 risk factor phenotypes in 8,554 individuals identifies loci influencing chronic disease
The basal transcription complex component TAF3 transduces changes in nuclear phosphoinositides into transcriptional output
Direct in vivo assessment of human stem cell grafthost neural circuits
Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors
Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells
Improvement and decline in vision with gene therapy in childhood blindness
Global developmental gene programing involves a nuclear form of fibroblast growth factor receptor-1 (FGFR1)
Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes
Federal regulatory oversight of US clinics marketing adipose-derived autologous stem cell interventions: insights from 3 new FDA draft guidance documents
Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies
Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: preliminary results in asian patients
Functional integration of human neural precursor cells in mouse cortex
Perinatal outcomes and unconventional natural gas operations in southwest Pennsylvania
Functional integration of human neural precursor cells in mouse cortex
Calcium release channel RyR2 regulates insulin release and glucose homeostasis
The innate immune system contributes to tissue-engineered vascular graft performance
A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis
G&T-seq: parallel sequencing of single-cell genomes and transcriptomes
Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteriaspecific CD4+ T cells
New self-assembling multifunctional templates for the biofabrication and controlled self-release of cultured tissue
Twenty-four-hour intraocular pressure patterns in patients with thyroid eye disease
Chemically fixed autologous feeder cell-derived niche for human induced pluripotent stem cell culture
Paternally contributed centrioles exhibit exceptional persistence in C. elegans embryos
Neurovascular crosstalk between interneurons and capillaries is required for vision
FOXO1 differentially regulates both normal and diabetic wound healing
Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism
ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation
siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown
Galanin modulates the neural niche to favour perineural invasion in head and neck cancer
Targeting breast to brain metastatic tumours with death receptor ligand expressing therapeutic stem cells
Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy
Ultrasound-induced modulation of cardiac rhythm in neonatal rat ventricular cardiomyocytes
Placental mesenchymal stromal cells rescue ambulation in ovine myelomeningocele
The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3
Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes
CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo
Intratumoral myeloid cells regulate responsiveness and resistance to antiangiogenic therapy
Evaluation of postural control in patients with glaucoma using a virtual reality environment
The basic helix-loop-helix transcription factor E47 reprograms human pancreatic cancer cells to a quiescent acinar state with reduced tumorigenic potential
An emerging era of clinical benefit from gene therapy
Outcomes following gene therapy in patients with severe Wiskott-Aldrich Syndrome
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo
Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure
Repression of SRF target genes is critical for Myc‐dependent apoptosis of epithelial cells
Molecular remodeling of the presynaptic active zone of Drosophila photoreceptors via activity-dependent feedback
A single epidermal stem cell strategy for safe ex vivo gene therapy
Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration
The role of multicellular aggregation in the survival of ErbB2-positive breast cancer cells during extracellular matrix detachment
Regulatory T cells are not a strong predictor of survival for patients with glioblastoma
Autologous adipose tissue-derived stromal vascular fraction cells application in patients with osteoarthritis
Innate lymphoid cells control early colonization resistance against intestinal pathogens through ID2-dependent regulation of the microbiota
A prevascularized subcutaneous device-less site for islet and cellular transplantation
The suture provides a niche for mesenchymal stem cells of craniofacial bones
Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells
Three-dimensional imaging of biological cells with picosecond ultrasonics
Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity
Real-time visualization of nanoparticles interacting with glioblastoma stem cells
Towards protein-based viral mimetics for cancer therapies
Serum- glucocorticoid-inducible kinase 1 confers protection in cell-based and in in vivo neurotoxin models via the c-Jun N-terminal kinase signaling pathway
In situ vascularization of injectable fibrin/poly(ethylene glycol) hydrogels by human amniotic fluid-derived stem cells
CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation
Plasticity of Hopx+ type I alveolar cells to regenerate type II cells in the lung
Trauma in silico: individual-specific mathematical models and virtual clinical populations
Faster T-cell development following gene therapy compared to haplo-identical hematopoietic stem cell transplantation in the treatment of SCID-X1
Modeling familial cancer with induced pluripotent stem cells
Functional analysis of the engineered cardiac tissue grown on recombinant spidroin fiber meshes
YAP1 regulates OCT4 activity and SOX2 expression to facilitate self-renewal and vascular mimicry of stem-like cells
High-resolution whole-brain staining for electron microscopic circuit reconstruction
A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells
KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth
Bending gradients: how the intestinal stem cell gets its home
Microencapsulated equine mesenchymal stromal cells promote cutaneous wound healing in vitro
Human iPSC-derived neural progenitors preserve vision in an AMD-like model
Enhancement of radiation effect on cancer cells by gold-pHLIP
Efficiency of conditionally attenuated Salmonella enterica serovar typhimurium in bacterium-mediated tumor therapy
Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration
Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth
Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness
Robust enumeration of cell subsets from tissue expression profiles
Genetic and functional characterization of clonally derived adult human brown adipocytes
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissueresident regulatory T cells
Predicting internal cell fluxes at sub-optimal growth
Microsecond scale vibrational spectroscopic imaging by multiplex stimulated Raman scattering microscopy
A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response
Patterned and functionalized nanofiber scaffolds in three-dimensional hydrogel constructs enhance neurite outgrowth and directional control
Novel advancements in three-dimensional neural tissue engineering and regenerative medicine
Telomerase mutations in smokers with severe emphysema
Telomere dysfunction causes alveolar stem cell failure
Label-free in vivo molecular imaging of underglycosylated mucin-1 expression in tumour cells
Antiaging treatment of the facial skin by fat graft and adipose-derived stem cells
Inflammatory dysregulation of blood monocytes in Parkinson's disease patients
Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice
Acoustic separation of circulating tumor cells
Mitochondrial alterations by PARKIN in dopaminergic neurons using PARK2 patient-specific and PARK2 knockout isogenic ipsc lines
Mitomycin-treated undifferentiated embryonic stem cells as a safe and effective therapeutic strategy in a mouse model of Parkinsons disease
Designing dual-functionalized gels for self-reconfiguration and autonomous motion
In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain
Long-term mechanical circulatory support (destination therapy): on track to compete with heart transplantation?
A computational, tissue-realistic model of pressure ulcer formation in individuals with spinal cord injury
Achieving synchronization with active hybrid materials: Coupling self-oscillating gels and piezoelectric films
Embryonic origin of postnatal neural stem cells
Embryonic stem cellderived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction
A new model for post-integration latency in macroglial cells to study HIV-1 reservoirs of the brain
The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing
Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer
Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions
Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy
Artificial membrane-binding proteins stimulate oxygenation of stem cells during engineering of large cartilage tissue
Diabetes primes neutrophils to undergo NETosis, which impairs wound healing
Single mammalian cells compensate for differences in cellular volume and DNA copy number through independent global transcriptional mechanisms
shRNA targeting α-synuclein prevents neurodegeneration in a Parkinsons disease model
A new technique for modeling neuronal connectivity using human pluripotent stem cells
MtDNA mutagenesis disrupts pluripotent stem cell function by altering redox signaling
A combined omics approach to generate the surface atlas of human naive CD4 T cells during early TCR activation
Decrease in cell volume generates contractile forces driving dorsal closure
Potent cell-intrinsic immune responses in dendritic cells facilitate HIV-1-specific T cell immunity in HIV-1 elite controllers
Optical imaging of the chorioretinal vasculature in the living human eye
Transcription factor PRDM8 is required for rod bipolar and type 2 OFF-cone bipolar cell survival and amacrine subtype identity
Generation of induced pluripotent stem cells from frozen buffy coats using non-integrating episomal plasmids
Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome
Real-time imaging of dendritic cell responses to sterile tissue injury
hESC differentiation toward an autonomic neuronal cell fate depends on distinct cues from the co-patterning vasculature
High graft CD8 cell dose predicts improved survival and enables better donor selection in allogeneic stem-cell transplantation with reduced-intensity conditioning
Dynamical system modeling of immune reconstitution after allogeneic stem cell transplantation identifies patients at risk for adverse outcomes
Human embryonic stem cell-derived progenitors assist functional sensory regeneration after dorsal root avulsion injury
A unique gene regulatory network resets the human germline epigenome for development
Cell fusion connects oncogenesis with tumor evolution
Myxoma virus suppresses proliferation of activated T lymphocytes yet permits oncolytic virus transfer to cancer cells
Modulation of cell function by electric field: a high-resolution analysis
Autologous bone marrow mononuclear cells reduce therapeutic intensity for severe traumatic brain injury in children
Aging-induced stem cell mutations as drivers for disease and cancer
A noisy linear map underlies oscillations in cell size and gene expression in bacteria
Can metabolic mechanisms of stem cell maintenance explain aging and the immortal germline?
Programming and reprogramming cellular age in the era of induced pluripotency
Stem cell aging and sex: are we missing something?
Single transcription factor conversion of human blood fate to NPCs with CNS and PNS developmental capacity
Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
Potential of systemic allogeneic mesenchymal stromal cell therapy for children with recessive dystrophic epidermolysis bullosa
Prmt5 is a regulator of muscle stem cell expansion in adult mice
3D printing of highly stretchable and tough hydrogels into complex, cellularized structures
Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1
Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces
Folding and imaging of DNA nanostructures in anhydrous and hydrated deep-eutectic solvents
Allogeneic neural stem/progenitor cells derived from embryonic stem cells promote functional recovery after transplantation into injured spinal cord of nonhuman primates
Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis
Chromothripsis from DNA damage in micronuclei
T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses
Sensitive detection of chromatin-altering polymorphisms reveals autoimmune disease mechanisms
KPC and NDM-1 genes in related Enterobacteriaceae strains and plasmids from Pakistan and the United States
Posttraumatic stress disorder and incident heart failure among a community-based sample of US veterans
Circulating tumor cell biomarker panel as an individual-level surrogate for survival in metastatic castration-resistant prostate cancer
Endogenous metabolites and inflammasome activity in early childhood and links to respiratory diseases
Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells
IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice
Characterization of host and microbial determinants in individuals with latent Tuberculosis infection using a human granuloma model
Incomplete immune reconstitution despite virologic suppression in HIV-1 infected children and adolescents
Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart
In vitro generation of human pluripotent stem cell derived lung organoids
Design and synthesis of a MAO-B-selectively activated prodrug based on MPTP: a mitochondria-targeting chemotherapeutic agent for treatment of human malignant gliomas
NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage
Fidgetin-like 2: a microtubule-based regulator of wound healing
Functional heterogeneity in the CD4+ T cell response to murine γ-herpesvirus 68
A novel risk score to predict cardiovascular disease risk in national populations (Globorisk): a pooled analysis of prospective cohorts and health examination surveys
Neuromedin S-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms
The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells
Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages
Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice
MG53-mediated cell membrane repair protects against acute kidney injury
Combination therapy of mesenchymal stem cells and serelaxin effectively attenuates renal fibrosis in obstructive nephropathy
A soluble biocompatible guanidine-containing polyamidoamine as promoter of primary brain cell adhesion and in vitro cell culturing
Transgenic mice with a diverse human T cell antigen receptor repertoire
Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice
Deletion of macrophage vitamin D receptor promotes insulin resistance and monocyte cholesterol transport to accelerate atherosclerosis in mice
Maturation of the proteasome core particle induces an affinity switch that controls regulatory particle association
Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling
High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells
In vivo study of magnesium plate and screw degradation and bone fracture healing
Collisions of deformable cells lead to collective migration
Targeting bacteria via iminoboronate chemistry of amine-presenting lipids
Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs
Image fusion of mass spectrometry and microscopy: a multimodality paradigm for molecular tissue mapping
Liver-directed lentiviral gene therapy in a dog model of hemophilia B
ChIP-nexus enables improved detection of in vivo transcription factor binding footprints
Mouse low-grade gliomas contain cancer stem cells with unique molecular and functional properties
Virus-specific T lymphocytes home to the skin during natural dengue infection
DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization
The Achilles heel of senescent cells: from transcriptome to senolytic drugs
Elucidating molecular phenotypes caused by the SORL1 Alzheimers disease genetic risk factor using human induced pluripotent stem cells
Lymphoid regeneration from Gene-corrected SCID-X1 subject-derived iPSCs
Surgery versus nonsurgical treatment of lumbar spinal stenosis: a randomized trial
Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window
A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication
Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium
Wireless magnetothermal deep brain stimulation
An autologous endothelial cell:peripheral blood mononuclear cell assay that detects cytokine storm responses to biologics
Disruption of DNA-methylation-dependent long gene repression in Rett syndrome
Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone
Human Ebola virus infection results in substantial immune activation
Systemic administration of epothilone B promotes axon regeneration after spinal cord injury
Human Leukocyte Antigen (HLA) A*1101-restricted Epstein-Barr virus-specific T-cell receptor gene transfer to target Nasopharyngeal carcinoma
Notch1Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration
Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population
Media Portray Unrealistic Timelines for Stem Cell Therapies
Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system
Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue
Interplay between population firing stability and single neuron dynamics in hippocampal networks
An aptamer-functionalized chemomechanically modulated biomolecule catch-and-release system
Mitochondrial membrane potential is regulated by vimentin intermediate filaments
Implantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistance
Immunological mechanisms of the antitumor effects of supplemental oxygenation
Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells
Cartilage repair using human embryonic stem cell-derived chondroprogenitors
Mouse mammary stem cells express prognostic markers for triple-negative breast cancer
Wnt7a is a novel inducer of β-catenin-independent tumor-suppressive cellular senescence in lung cancer
Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection
Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb
Retroviral vectors elevate coexpressed protein levels in trans through cap-dependent translation
Dynamic transcription of distinct classes of endogenous retroviral elements marks specific populations of early human embryonic cells
Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats
Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children
Hepatic stellate cell‐expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage
A small-molecule screen for enhanced homing of systemically infused cells
In vivo generation of a mature and functional artificial skeletal muscle
Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions
TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma
Genetic studies of body mass index yield new insights for obesity biology
Zyxin antagonizes the FERM protein expanded to couple F-actin and yorkie-dependent organ growth
Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia
An evolutionary role for HIV latency in enhancing viral transmission
A hardwired HIV latency program
DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior
Individual T helper cells have a quantitative cytokine memory
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells
Differentiation of hypothalamic-like neurons from human pluripotent stem cells
Th17 inflammation model of oropharyngeal candidiasis in immunodeficient mice
Visual impairment and blindness avoided with ranibizumab in hispanic and non-hispanic whites with diabetic macular edema in the United States
(-)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization (LMP)
Adipogenic differentiation of hMSCs is mediated by recruitment of IGF-1R onto the primary cilium associated with cilia elongation
Rational development and characterization of humanized antiEGFR variant III chimeric antigen receptor T cells for glioblastoma
Integrative analysis of 111 reference human epigenomes
Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema
Self-assembled hydrogels utilizing polymernanoparticle interactions
Engineering gold nanotubes with controlled length and near-infrared absorption for theranostic applications
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Mechanical stress and network structure drive protein dynamics during cytokinesis
Stem cell transplantation reverses chemotherapy-induced cognitive dysfunction
A conserved regulatory logic controls temporal identity in mouse neural progenitors
Resetting the transcription factor network reverses terminal chronic hepatic failure
Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
CRISPR-based self-cleaving mechanism for controllable gene delivery in human cells
Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy
Force-controlled patch clamp of beating cardiac cells
Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17producing CD4+ T cells
64Cu antibody-targeting of the T-cell receptor and subsequent internalization enables in vivo tracking of lymphocytes by PET
Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs
Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types
Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye
Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo
MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signaling in cancer
Pharmacological activation of myosin II paralogs to correct cell mechanics defects
Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack
Human umbilical cord blood cells induce neuroprotective change in gene expression profile in neurons after ischemia through activation of Akt pathway
A light-inducible CRISPR-Cas9 system for control of endogenous gene activation
Blood biocompatibility of surface-bound multi-walled carbon nanotubes
Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition
Monoterpene (−)-citronellal affects hepatocarcinoma cell signaling via an olfactory receptor
B-lymphocyte-mediated delayed cognitive impairment following stroke
Expenditures and health status among adults with back and neck problems
Repression of intestinal stem cell function and tumorigenesis through direct phosphorylation of β-catenin and Yap by PKCζ
Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems
Memory T cells specific for murine cytomegalovirus re-emerge after multiple challenges and recapitulate immunity in various adoptive transfer scenarios
Life-long in vivo cell-lineage tracing shows that no oogenesis originates from putative germline stem cells in adult mice
Class-switched memory B cells remodel BCRs within secondary germinal centers
HIV-1 integration landscape during latent and active infection
Human iPSC-derived hepatocyte-like cells support plasmodium liver-stage infection in vitro
NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival
Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo
Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis
Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells
Real-time deformability cytometry: on-the-fly cell mechanical phenotyping
Disruption of the head direction cell network impairs the parahippocampal grid cell signal
Variable expression of PIK3R3 and PTEN in Ewing Sarcoma impacts oncogenic phenotypes
Human dermal CD14⁺ cells are a transient population of monocyte-derived macrophages
Maturation of embryonic tissues in a lymph node: a new approach for bioengineering complex organs
Dental pulp stem cells: a new cellular resource for corneal stromal regeneration
Nanosecond laser therapy reverses pathologic and molecular changes in age-related macular degeneration without retinal damage
Brush-like polycarbonates containing dopamine, cations, and PEG providing a broad-spectrum, antibacterial, and antifouling surface via one-step coating
Modeling the natural history of PelizaeusMerzbacher disease
Common genetic variants influence human subcortical brain structures
Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells
Rapid formation of a supramolecular polypeptideDNA hydrogel for in situ three-dimensional multilayer bioprinting
Derivation of hair-inducing cell from human pluripotent stem cells
KLRG+ invariant natural killer T cells are long-lived effectors
Highly angiogenic peptide nanofibers
Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs
Differential prooxidative effects of the green tea polyphenol, ()-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling
FOXO1 promotes wound healing through the up-regulation of TGF-β1 and prevention of oxidative stress
Foxo1 inhibits diabetic mucosal wound healing but enhances healing of normoglycemic wounds
Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer
Hematopoietic stem cell transplantation for MS--extraordinary evidence still needed
Association of nonmyeloablative hematopoietic stem cell transplantation with neurological disability in patients with relapsing-remitting multiple sclerosis
Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy
Human neural stem cell intracerebral grafts show spontaneous early neuronal differentiation after several weeks
Human iPS cell-derived insulin producing cells form vascularized organoids under the kidney capsules of diabetic mice
Multiple myeloma
Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus
Time-resolved video analysis and management system for monitoring cardiomyocyte differentiation processes and toxicology assays
An intermittent rocking platform for integrated expansion and differentiation of human pluripotent stem cells to cardiomyocytes in suspended microcarrier cultures
Conjoint propagation and differentiation of human embryonic stem cells to cardiomyocytes in a defined microcarrier spinner culture
Considerations in designing systems for large scale production of human cardiomyocytes from pluripotent stem cells
A role of autophagy in PTP4A3-driven cancer progression
Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer
Loss of STAT3 in murine NK cells enhances NK celldependent tumor surveillance
A dominant mutation in hexokinase 1 (HK1) causes retinitis pigmentosa
Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy
Programming thermoresponsiveness of nanovelcro substrates enables effective purification of circulating tumor cells in lung cancer patients
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion
Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells
Variation in the human immune system is largely driven by non-heritable influences
Chimeric antigen receptor T Cells for sustained remissions in leukemia
Mutations in PNPLA6 are linked to photoreceptor degeneration and various forms of childhood blindness
Microfluidic device for stem cell differentiation and localized electroporation of postmitotic neurons
Amplifying the red-emission of upconverting nanoparticles for biocompatible clinically used prodrug-induced photodynamic therapy
Fast sorting of CD4+ T cells from whole blood using glass microbubbles
DNA brick crystals with prescribed depths
Clinical disease due to enterovirus D68 in adult hematologic malignancy patients and hematopoietic cell transplant recipients
Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential
Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells
Association of COMT and TPH-2 genes with DSM-5 based PTSD symptoms
Severity of age-related macular degeneration in 1 eye and the incidence and progression of age-related macular degeneration in the fellow eye
Proteome profiling of breast cancer biopsies reveals a wound healing signature of cancer-associated fibroblasts
Vascular channels formed by subpopulations of PECAM1+ melanoma cells
Treatment of chronic graft-versus-host disease with bortezomib
An α2-Na/K ATPase/α-adducin complex in astrocytes triggers noncell autonomous neurodegeneration
Generation of human striatal neurons by microRNA-dependent direct conversion of fibroblasts
Murine and human tissue-engineered esophagus form from sufficient stem/progenitor cells and do not require microdesigned biomaterials
EphA4 receptor shedding regulates spinal motor axon guidance
The cavefish genome reveals candidate genes for eye loss
Rapid modelling of cooperating genetic events in cancer through somatic genome editing
Nanoparticle tension probes patterned at the nanoscale: impact of integrin clustering on force transmission
DNA-based digital tension probes reveal integrin forces during early cell adhesion
Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease
Actin stress in cell reprogramming
CD8 T cells in innate immune responses: using STAT4-dependent but antigen-independent pathways to gamma interferon during viral infection
Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability
Activated CD4+CCR5+ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques
CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells
Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling
X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency
Innate lymphoid cells regulate intestinal epithelial cell glycosylation
Quantitative SD-OCT imaging biomarkers as indicators of age-related macular degeneration progression
BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs
Dendrimer-encapsulated naphthalocyanine as a single agent-based theranostic nanoplatform for near-infrared fluorescence imaging and combinatorial anticancer phototherapy
Engineered coiled-coil protein microfibers
The e-incubator: a magnetic resonance imaging-compatible mini incubator
Chronic hypertension increases susceptibility to acute IOP challenge in rats
Adipose fatty acid oxidation is required for thermogenesis and potentiates oxidative stress-induced inflammation
Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth
Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions
Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter
Enteric bacteria promote human and mouse norovirus infection of B cells
CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer
Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations
Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes
Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans
Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells
Nanoparticle-mediated binning and profiling of heterogeneous circulating tumor cell subpopulations
Transdifferentiation of human fibroblasts to endothelial cells: role of innate immunity
Cell-size control and homeostasis in bacteria
Comparable frequencies of coding mutations and loss of imprinting in human pluripotent cells derived by nuclear transfer and defined factors
A biodegradable tri-component graft for anterior cruciate ligament reconstruction
Crystal structure of Cas9 in complex with guide RNA and target DNA
A prognostic score for acute graft-versus-host disease based on biomarkers: a multicentre study
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity
Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion
Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes
Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9
Dynamic acoustic field activated cell separation (DAFACS)
An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator
Proteome adaptation in cell reprogramming proceeds via distinct transcriptional networks
Small RNA changes en route to distinct cellular states of induced pluripotency
Divergent reprogramming routes lead to alternative stem-cell states
Genome-wide characterization of the routes to pluripotency
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage
Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes
Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers
Human genetics shape the gut microbiome
Macrophages sense and kill bacteria through carbon monoxidedependent inflammasome activation
Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia
Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation
Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial
Global prevalence of glaucoma and projections of glaucoma burden through 2040
A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential
The common chymotrypsinogen C (CTRC) variant G60G (C.180T) increases risk of chronic pancreatitis but not recurrent acute pancreatitis in a North American population
Inhibiting EGFR clustering and cell proliferation with gold nanoparticles
Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction
Thy1 (CD90) controls adipogenesis by regulating activity of the Src family kinase, Fyn
Functional Toll-like receptors in primary first-trimester trophoblasts
Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state
Risk factors for developing thyroid-associated ophthalmopathy among individuals with Graves disease
Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways
Oligodendrocyte precursor cells modulate the neuronal network by activity-dependent ectodomain cleavage of glial NG2
SNAIL-induced epithelial-to-mesenchymal transition produces concerted biophysical changes from altered cytoskeletal gene expression
The progenitor state is maintained by lysine-specific demethylase 1-mediated epigenetic plasticity during Drosophila follicle cell development
An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA
PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis
A Wnt-TGFβ2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice
Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing
Prospective evaluation of teleophthalmology in screening and recurrence monitoring of neovascular age-related macular degeneration--a randomized clinical trial
Stem cell transplantation as a dynamical system: are clinical outcomes deterministic?
In silico derivation of HLA-specific alloreactivity potential from whole exome sequencing of stem-cell transplant donors and recipients: understanding the quantitative immunobiology of allogeneic transplantation
Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances
Parkin sensitizes toward apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1
Prostaglandin signaling suppresses beneficial microglial function in Alzheimers disease models
Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis
Cellular complexity captured in durable silica biocomposites
Mechanically encoded cellular shapes for synthesis of anisotropic mesoporous particles
Synthetic fossilization of soft biological tissues and their shape-preserving transformation into silica or electron-conductive replicas
A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells
Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells
Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic cluster
Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic variants
Activation of toll-like receptor-2 by endogenous matrix metalloproteinase-2 modulates dendritic-cell-mediated inflammatory responses
A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer
Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-α
Deconstructing transcriptional heterogeneity in pluripotent stem cells
Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B-cell activation and proliferation
Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis
Nanomimics of host cell membranes block invasion and expose invasive malaria parasites
Age-related variations in the methylome associated with gene expression in human monocytes and T cells
Topoisomerases facilitate transcription of long genes linked to autism
Topoisomerase 1 inhibition reversibly impairs synaptic function
Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound
Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins
Time-variant clustering model for understanding cell fate decisions
Cell fate inclination within 2-cell and 4-cell mouse embryos revealed by single-cell RNA sequencing
NanoScript: a nanoparticle-based artificial transcription factor for effective gene regulation
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow
The timing of upper-layer neurogenesis is conferred by sequential derepression and negative feedback from deep-layer neurons
Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors
Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
Nitric oxide mediates metabolic coupling of omentum-derived adipose to ovarian and endometrial cancer cells
Somatic transcriptome priming gates lineage-specific differentiation potential of human-induced pluripotent stem cell states
Human limbal biopsyderived stromal stem cells prevent corneal scarring
Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin
Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion
Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines
Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance
Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire
Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer
SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts
Selective conversion of fibroblasts into peripheral sensory neurons
Modulation of the maladaptive stress response to manage diseases of protein folding
Inorganicorganic hybrid nanoprobe for NIR-excited imaging of hydrogen sulfide in cell cultures and inflammation in a mouse model
Nanoprobes: inorganicorganic hybrid nanoprobe for NIR-excited imaging of hydrogen sulfide in cell cultures and inflammation in a mouse model
A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones
Nanosecond laser therapy reverses pathologic and molecular changes in age-related macular degeneration without retinal damage
Panel-based genetic diagnostic testing for inherited eye diseases is highly accurate and reproducible, and more sensitive for variant detection, than exome sequencing
The immune synapse clears and excludes molecules above a size threshold
Long-term safety and efficacy of factor IX gene therapy in hemophilia B
The angiogenic factor PlGF mediates a neuroimmune interaction in the spleen to allow the onset of hypertension
PHD3 regulates EGFR internalization and signalling in tumours
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR
Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection
An integrated catalog of reference genes in the human gut microbiome
A rare human syndrome provides genetic evidence that WNT signaling is required for reprogramming of fibroblasts to induced pluripotent stem cells
A proteome-scale map of the human interactome network
Protein tyrosine phosphataseσ regulates hematopoietic stem cellrepopulating capacity
Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimers disease mouse model
Phenylboronic acid modified mucoadhesive nanoparticle drug carriers facilitate weekly treatment of experimentallyinduced dry eye syndrome
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
Reversal of cognitive decline: A novel therapeutic program
Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells
The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells
Combining random gene fission and rational gene fusion to discover near-infrared fluorescent protein fragments that report on proteinprotein interactions
Salivary gland cancer in BRCA-positive families--a retrospective review
Magneto-fluorescent core-shell supernanoparticles
Molecular convergence of neurodevelopmental disorders
Stochastic variations of migration speed between cells in clonal populations
A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse
PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis
Life-long correction of hyperbilirubinemia with a neonatal liver-specific AAV-mediated gene transfer in a lethal mouse model of CriglerNajjar Syndrome
Direct cellcell contact with the vascular niche maintains quiescent neural stem cells
Clonal dynamics of native haematopoiesis
Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency
Cortical representations are reinstated by the hippocampus during memory retrieval
Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein
Gene expression-based enrichment of live cells from adipose tissue produces subpopulations with improved osteogenic potential
Quality assurance in diabetic retinal screening in South Africa
Mitochondrial haplogroups are associated with severity of diabetic retinopathy
Preservation of genetic and regulatory robustness in ancient gene duplicates of Saccharomyces cerevisiae
Gold nanoparticle-decellularized matrix hybrids for cardiac tissue engineering
Nanoscale resistive switching in amorphous perovskite oxide (a-SrTiO3) memristors
Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes
Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo
Solid-to-fluid DNA transition inside HSV-1 capsid close to the temperature of infection
Solid-to-fluidlike DNA transition in viruses facilitates infection
Pulmonary macrophage transplantation therapy
Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system
Cellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell population
Clinical cell therapy imaging using a perfluorocarbon tracer and fluorine-19 MRI
Regulated assembly and disassembly of the yeast telomerase quaternary complex
Anti-inflammatory therapy after selective laser trabeculoplasty
Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes
Bacterial quorum sensing molecule N-3-Oxo-Dodecanoyl-L-Homoserine Lactone causes direct cytotoxicity and reduced cell motility in human pancreatic carcinoma cells
Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal
Delivery of antibody mimics into mammalian cells via anthrax toxin protective antigen
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease
Systematic discovery of novel ciliary genes through functional genomics in the zebrafish
Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma
Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma
Resetting transcription factor control circuitry toward ground-state pluripotency in human
Hey1 and Hey2 control the spatial and temporal pattern of mammalian auditory hair cell differentiation downstream of Hedgehog signaling
MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM
The developmental potential of iPSCs is greatly influenced by reprogramming factor selection
Enhanced re-endothelialization of acellular kidney scaffolds for whole organ engineering via antibody conjugation of vasculatures
Specific roles for dendritic cell subsets during initiation and progression of psoriasis
A 5-gene classifier from the carcinoma-associated fibroblast transcriptomic profile and clinical outcome in colorectal cancer
The developmental potential of iPSCs is greatly influenced by reprogramming factor selection
Histone variant H2A.X deposition pattern serves as a functional epigenetic mark for distinguishing the developmental potentials of iPSCs
Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification
PAX7 expression defines germline stem cells in the adult testis
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
Diversification of TAM receptor tyrosine kinase function
Inhibition of JAK-STAT signaling stimulates adult satellite cell function
Optical assay of erythrocyte function in banked blood
The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum
Natively inhibited Trypanosoma brucei Cathepsin B structure determined by using an x-ray laser
A potential wound-healing-promoting peptide from salamander skin
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial
Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting
Live human nasal epithelial cells (hNECs) on chip for in vitro testing of gaseous formaldehyde toxicity via airway delivery
In vitro modeling of the neurovascular environment by coculturing adult human brain endothelial cells with human neural stem cells
Mechanochemical actuators of embryonic epithelial contractility
The effect of a connexin43-based peptide on the healing of chronic venous leg ulcers: a multicenter, randomized trial
Loss and dysfunction of Vδ2+ γδ T cells are associated with clinical tolerance to malaria
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma
Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma
Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma
An implantable microfluidic device for self-monitoring of intraocular pressure
Intrathecal gene therapy corrects CNS pathology in a feline model of mucopolysaccharidosis I
An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts
Cell separation using tilted-angle standing surface acoustic waves
Engineering patient-specific valves using stem cells generated from skin biopsy specimens
Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages
Improvement in spinal cord injury-induced bladder fibrosis using mesenchymal stem cell transplantation into the bladder wall
Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis
Assemblages: functional units formed by cellular phase separation
A toxic RNA catalyzes the in cellulo synthesis of its own inhibitor
UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity
28-day intraocular pressure reduction with a single dose of brimonidine tartrate-loaded microspheres
Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence
Molecular imaging reveals elevated VEGFR-2 expression in retinal capillaries in diabetes: a novel biomarker for early diagnosis
Communication through resonance in spiking neuronal networks
Bleb-driven chemotaxis of Dictyostelium cells
How blebs and pseudopods cooperate during chemotaxis
Native American ancestry is associated with severe diabetic retinopathy in Latinos
Adipose derived stem cells and nerve regeneration
Function of a Foxp3 cis-element in protecting regulatory T cell identity
Use of differentiated pluripotent stem cells as replacement therapy for treating disease
Synaptic dysregulation in a human iPS cell model of mental disorders
Preparing the ground for tissue regeneration: from mechanism to therapy
Partial restoration of cardiac function with ΔPDZ nNOS in aged mdx model of Duchenne cardiomyopathy
Hand-held and integrated single-cell pipettes
Generation of multipotent induced neural crest by direct reprogramming of human postnatal fibroblasts with a single transcription factor
Detection of minimal residual disease in B lymphoblastic leukemia by high-throughput sequencing of IGH
Integrin αvβ3 drives slug activation and stemness in the pregnant and neoplastic mammary gland
Novel fusion transcripts associate with progressive prostate cancer
Inhibition of Protein Phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells
Sequential histone-modifying activities determine the robustness of transdifferentiation
Collective and individual migration following the epithelialmesenchymal transition
Cytokinesis failure triggers Hippo tumor suppressor pathway activation
Dissecting engineered cell types and enhancing cell fate conversion via CellNet
CellNet: network biology applied to stem cell engineering
The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy
Forces driving epithelial wound healing
Protein competition switches the function of COP9 from self-renewal to differentiation
H3K4me3 breadth is linked to cell identity and transcriptional consistency
Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex
Interplay of matrix stiffness and protein tethering in stem cell differentiation
Multimonth controlled small molecule release from biodegradable thin films
Efficient CRISPR-Cas9mediated genome editing in Plasmodium falciparum
Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays
The role of stem cells in aesthetic surgery: fact or fiction?
Induced neural stem cells achieve long-term survival and functional integration in the adult mouse brain
Most genetic risk for autism resides with common variation
Control of the survival and growth of human glioblastoma grafted into the spinal cord of mice by taking advantage of immunorejection
Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients
Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells using a bacterial CRISPR/Cas RNA-guided endonuclease
Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1
Surviving extreme exposure to ionizing radiation: Escherichia coli genes and pathways
Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in embryonic stem cells
The relationship of central foveal thickness to urinary iodine concentration in retinitis pigmentosa with or without cystoid macular edema
Glial origin of mesenchymal stem cells in a tooth model system
Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process
Directing the behavior of active, self-oscillating gels with light
Mesenchymal stem cells augment the adaptive response to eccentric exercise
Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing
Molecular extraction in single live cells by sneaking in and out magnetic nanomaterials
Prevalence of age-related macular degeneration in a large European cohort: Results from the population-based Gutenberg Health Study
Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity
Network analysis of breast cancer progression and reversal using a tree-evolving network algorithm
Heterogeneous tumor subpopulations cooperate to drive invasion
Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators
Cell-specific translational profiling in acute kidney injury
Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility
The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells
Relationship between leukocyte telomere length, telomerase activity, and hippocampal volume in early aging
Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection
A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes
Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma
ABCB5 is a limbal stem cell gene required for corneal development and repair
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Histone chaperone ASF1A is required for maintenance of pluripotency and cellular reprogramming
Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway
Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling
Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aβ accumulation
Kit regulates HSC engraftment across the human-mouse species barrier
Gene therapy in patient-specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled-related protein defects
Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss
Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics
In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity
Two sides of the same coin: stem cells in cancer and regenerative medicine
Leukemia propagating cells rebuild an evolving niche in response to therapy
Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells
Abnormalities in human pluripotent cells due to reprogramming mechanisms
Spatio‐temporally precise activation of engineered receptor tyrosine kinases by light
Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression
Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy
Three-dimensional cell migration does not follow a random walk
Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers
Genetic analysis of tissue glutathione concentrations and redox balance
A combined magnetophoresis/dielectrophoresis based microbead array as high-throughput biomolecular tweezers
The transcription factor titration effect dictates level of gene expression
The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons
Galvanotactic control of collective cell migration in epithelial monolayers
Systematic screen of chemotherapeutics in Drosophila stem cell tumors
Common genetic variants modulate pathogen-sensing responses in human dendritic cells
Serpins promote cancer cell survival and vascular co-option in brain metastasis
Defining cell-type specificity at the transcriptional level in human disease
Micropattern width dependent sarcomere development in human ESC-derived cardiomyocytes
Vaccination with tumor cells expressing IL-15 and IL-15Rα inhibits murine breast and prostate cancer
A dedicated circuit links direction-selective retinal ganglion cells to the primary visual cortex
Clinical imaging in regenerative medicine
Human immunodeficiency virus-1 tat protein increases the number of inhibitory synapses between hippocampal neurons in culture
Cyclic AMP stimulates neurite outgrowth of lamprey reticulospinal neurons without substantially altering their biophysical properties
Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy
Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells
Increased cerebral activation after behavioral treatment for memory deficits in MS
Let's rehabilitate cognitive rehabilitation in multiple sclerosis
An RCT to treat learning impairment in multiple sclerosis: The MEMREHAB trial
Wharton's jelly stem cells: A novel cell source for oral mucosa and skin epithelia regeneration
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations
Ossifying fibroma tumor stem cells are maintained by epigenetic regulation of a TSP1/TGF-β/SMAD3 autocrine loop
Bovine lactoferricin B induces apoptosis of human gastric cancer cell line AGS by inhibition of autophagy at a late stage
Genome-wide consequences of deleting any single gene
Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis
CO2 directly modulates connexin 26 by formation of carbamate bridges between subunits
TH17 cell differentiation is regulated by the circadian clock
Pediatric fecal microbiota harbor diverse and novel antibiotic resistance genes
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Zero-dimensional single-walled carbon nanotubes
Reliable encoding of stimulus intensities within random sequences of intracellular Ca2+ spikes
Filaments in curved streamlines: rapid formation of Staphylococcus aureus biofilm streamers
Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity
A role for intrathymic B cells in the generation of natural regulatory T cells
miRNAs 182 and 183 are necessary to maintain adult cone photoreceptor outer segments and visual function
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1
IL-2inducible T cell kinase tunes T regulatory cell development and is required for suppressive function
Transcription factor induction of human oligodendrocyte progenitor fate and differentiation
Dental pulp stem cells, a paracrine-mediated therapy for the retina
Activity of broad-spectrum T cells as treatment for AdV, EBV, CMV, BKV, and HHV6 infections after HSCT
Plasmonic gold nanoparticles modified titania nanotubes for antibacterial application
Effect of marihuana on intraocular and blood pressure in glaucoma
Marijuana smoking and reduced pressure in human eyes: drug action or epiphenomenon?
A wireless intraocular pressure monitoring device with a solder-filled microchannel antenna
Electrophysiological analysis of biopsy samples using elasticity as an inherent cell marker for cancer detection
Cooperative, reversible self-assembly of covalently pre-linked proteins into giant fibrous structures
A multiscale agent-based in silico model of liver fibrosis progression
TRF2, but not TBP, mediates the transcription of ribosomal protein genes
Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent notch signaling
Direct Rho-associated kinase inhibition [correction of inhibiton] induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells
Transplantation of mesenchymal stem cells to the brain by topical application in an experimental traumatic brain injury model
Stem cells in neuroinjury and neurodegenerative disorders: challenges and future neurotherapeutic prospects
Cell therapy with G-CSF-mobilized stem cells in a rat osteoarthritis model
CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes
Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial
Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation
α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration
The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation
Lowest numbers of primary CD8+ T cells can reconstitute protective immunity upon adoptive immunotherapy
Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of Multiple Sclerosis
Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms
Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations
Identification of specific cell-surface markers of adipose-derived stem cells from subcutaneous and visceral fat depots
Introducing mixed-charge copolymers as wound dressing biomaterials
Association between intensification of metformin treatment with insulin vs sulfonylureas and cardiovascular events and all-cause mortality among patients with diabetes
Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection
APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development
Reactivation of multiple viruses in patients with sepsis
Numerical modelling of a healthy/malaria-infected erythrocyte in shear flow using dissipative particle dynamics method
Mechanisms of CFTR functional variants that impair regulated bicarbonate permeation and increase risk for pancreatitis but not for cystic fibrosis
Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells
The nanoscale geometrical maturation of focal adhesions controls stem cell differentiation and mechanotransduction
Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor
Self-assembly of amphiphilic Janus dendrimers into uniform onion-like dendrimersomes with predictable size and number of bilayers
Functional connectivity in the basal ganglia network differentiates PD patients from controls
Cell-to-cell transfer of M. tuberculosis antigens optimizes CD4 T cell priming
Mesenchymal stem cells increase hippocampal neurogenesis and neuronal differentiation by enhancing the Wnt signaling pathway in Alzheimers disease model
Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs
Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac disease
Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection
Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients
Alcohol-related brain damage in humans
Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state
Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study
Rare mutations in RINT1 predispose carriers to breast and lynch syndrome-spectrum cancers
Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression
Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance
High-fidelity reproduction of spatiotemporal visual signals for retinal prosthesis
Nucleic acid sensing by T cells initiates Th2 cell differentiation
Small molecule capture and release from PEI-functionalized single walled carbon nanotubes with endoscopic ultrasound
Preparation and evaluation of polyethyleneimine-single walled carbon nanotube conjugates as vectors for pancreatic cancer treatment
Mesenchymal stem cells, neural lineage potential, heparan sulfate proteoglycans and the matrix
Photoactivation of endogenous latent transforming growth factorβ1 directs dental stem cell differentiation for regeneration
Long-term health of dopaminergic neuron transplants in Parkinson's disease patients
Microbial profiling of combat wound infection through detection microarray and next-generation sequencing
Mutant huntingtin is present in neuronal grafts in huntington disease patients
Generation of organized germ layers from a single mouse embryonic stem cell
Prospective randomized phase 2 trial of intensity modulated radiation therapy with or without oncolytic adenovirus-mediated cytotoxic gene therapy in intermediate-risk prostate cancer
Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice
Identification of distinct ChAT+ neurons and activity-dependent control of postnatal SVZ neurogenesis
Epigenomic comparison reveals activation of seed enhancers during transition from naive to primed pluripotency
Reusable, robust, and accurate laser-generated photonic nanosensor
Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation
Aiolos promotes anchorage independence by silencing p66shc transcription in cancer cells
Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1dependent ABL1 activation in endothelial cells
Brain pericytes acquire a microglial phenotype after stroke
Molecular profiling of neurons based on connectivity
Fluorogenic probes for live-cell imaging of the cytoskeleton
The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro
Multi-enzyme complexes on DNA scaffolds capable of substrate channelling with an artificial swinging arm
A TrioRac1Pak1 signalling axis drives invadopodia disassembly
ALIX is recruited temporarily into HIV-1 budding sites at the end of Gag assembly
Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication
Inhibition of mitochondrial protein import by mutant huntingtin
Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo
The dynamics of signaling as a pharmacological target
Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-κB activation
Stem cells loaded with multimechanistic oncolytic herpes simplex virus variants for brain tumor therapy
A centrifugal fluidic immunoassay for ocular diagnostics with an enzymatically hydrolyzed fluorogenic substrate
Automated telecommunication-based reminders and adherence with once-daily glaucoma medication dosing: the automated dosing reminder study
Electronic monitoring to assess adherence with once-daily glaucoma medications and risk factors for nonadherence: the automated dosing reminder study
Ultrashort peptide nanofibrous hydrogels for the acceleration of healing of burn wounds
The role of indoleamine 2,3 dioxygenase in beneficial effects of stem cells in hind limb ischemia reperfusion injury
Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia
Transgene delivery via intracellular electroporetic nanoinjection
A self-reconfiguring metamorphic nanoinjector for injection into mouse zygotes
Precise patterning of silk microstructures using photolithography
Silk protein lithography as a route to fabricate sericin microarchitectures
Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer
Enhanced anticancer efficacy by ATP-mediated liposomal drug delivery
Mesenchymal stem cells derived from adipose tissue vs bone marrow: in vitro comparison of their tropism towards gliomas
Mesenchymal stem cells from human fat engineered to secrete BMP4 are nononcogenic, suppress brain cancer, and prolong survival
12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor
Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin
High-dose interleukin-2 therapy for metastatic renal cell carcinoma: a contemporary experience
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis
Functional outcome after anal sphincter injury and treatment with mesenchymal stem cells
Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis
Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation
Geographic atrophy--a histopathological assessment
Clonal selection in the germinal centre by regulated proliferation and hypermutation
Stretched cell cycle model for proliferating lymphocytes
Metastatic ovarian cancer cell malignancy is increased on soft matrices through a mechanosensitive Rho/ROCK pathway
A proliferative burst during preadolescence establishes the final cardiomyocyte number
Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function
Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging
Tear film dynamics with evaporation, wetting, and time-dependent flux boundary condition on an eye-shaped domain
Deficits in bioenergetics and impaired immune response in granulocytes from children with autism
Prevention and screening programs for anterior cruciate ligament injuries in young athletes
Exosomes as critical agents of cardiac regeneration triggered by cell therapy
Thermodynamic basis for engineering high-affinity, high-specificity binding-induced DNA clamp nanoswitches
Temporal perturbation of the Wnt signaling pathway in the control of cell reprogramming is modulated by TCF1
Intracerebral implantation of autologous peripheral blood stem cells in stroke patients: a randomized phase II study
Fate of iPSCs derived from azoospermic and fertile men following xenotransplantation to murine seminiferous tubules
DNA Ligase I is not essential for mammalian cell viability
APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition
Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells
Biodegradable polymeric nanoparticles show high efficacy and specificity at DNA delivery to human glioblastoma in vitro and in vivo
A 3D sphere culture system containing functional polymers for large-scale human pluripotent stem cell production
Astrocyte-encoded positional cues maintain sensorimotor circuit integrity
Contact angle at the leading edge controls cell protrusion rate
Enhancing adult nerve regeneration through the knockdown of retinoblastoma protein
Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages
Large, stratified, and mechanically functional human cartilage grown in vitro by mesenchymal condensation
Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors
Close-field electroporation gene delivery using the cochlear implant electrode array enhances the bionic ear
Neurogenic potential of dental pulp stem cells isolated from murine incisors
Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells
Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion
Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca2+ channel sulfhydration
E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells
An integrin β3KRASRalB complex drives tumour stemness and resistance to EGFR inhibition
A module of human peripheral blood mononuclear cell transcriptional network containing primitive and differentiation markers is related to specific cardiovascular health variables
Modular extracellular sensor architecture for engineering mammalian cell-based devices
RNA as a boiling-resistant anionic polymer material to build robust structures with defined shape and stoichiometry
Regulatory interactions maintaining self-renewal of human embryonic stem cells as revealed through a systems analysis of P13K/AKT pathway
Crosstalk and the evolution of specificity in two-component signaling
In vivo adaptive optics microvascular imaging in diabetic patients without clinically severe diabetic retinopathy
Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models
Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells
Extracellular O-linked N-acetylglucosamine is enriched in stem cells derived from human umbilical cord blood
Total artificial heart in the pediatric patient with biventricular heart failure
Tissue-engineered autologous vaginal organs in patients: a pilot cohort study
Histone modification analysis by chromatin immunoprecipitation from a low number of cells on a microfluidic platform
Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer
Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats
Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq
Glaucoma Diabetes of the brain: A radical hypothesis about its nature and pathogenesis
Size evolution of highly amphiphilic macromolecular solution assemblies via a distinct bimodal pathway
Three-dimensional printing of Hela cells for cervical tumor model in vitro
Isolation of T cells from mouse oral tissues
Designing bioinspired artificial cilia to regulate particlesurface interactions
Engineered autologous cartilage tissue for nasal reconstruction after tumour resection: an observational first-in-human trial
Carbon nanotube chemiresistor for wireless pH sensing
p53 activity is selectively licensed in the Drosophila stem cell compartment
Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus
The RhoA guanine nucleotide exchange factor, LARG, mediates ICAM-1dependent mechanotransduction in endothelial cells to stimulate transendothelial migration
Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7
SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel
Multifunctional wearable devices for diagnosis and therapy of movement disorders
Pretreatment-dependent surface chemistry of wood nanocellulose for pH-sensitive hydrogels
Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells
Episodic binge ethanol exposure impairs murine macrophage infiltration and delays wound closure by promoting defects in early innate immune responses
Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinsons Disease
Meta-analysis of preclinical studies of mesenchymal stromal cells for ischemic stroke
Estimating the effective density of engineered nanomaterials for in vitro dosimetry
Disruption of the methyltransferase-like 23 gene METTL23 causes mild autosomal recessive intellectual disability
Truncation of the E3 ubiquitin ligase component FBXO31 causes non-syndromic autosomal recessive intellectual disability in a Pakistani family
Induction of human embryonic and induced pluripotent stem cells into urothelium
Derivation of myogenic progenitors directly from human pluripotent stem cells using a sphere-based culture
Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency
p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion
Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape
Both contractile axial and lateral traction force dynamics drive amoeboid cell motility
Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer
Gene therapy for Wiskott-Aldrich Syndromelong-term efficacy and genotoxicity
Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule
A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice
Combination therapy of human umbilical cord blood cells and granulocyte colony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury
Transfection of the glial cell line-derived neurotrophic factor gene promotes neuronal differentiation
Human finger-prick induced pluripotent stem cells facilitate the development of stem cell banking
Cartilage tissue engineering application of injectable gelatin hydrogel with in situ visible-light-activated gelation capability in both air and aqueous solution
An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss
Perivascular stromal cells as a potential reservoir of human cytomegalovirus
Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells
Haematopoietic stem cells require a highly regulated protein synthesis rate
Growth and proliferation of human embryonic stem cells on fully synthetic scaffolds based on carbon nanotubes
Inhibition of miR-25 improves cardiac contractility in the failing heart
Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates
A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease
Pancreatic islet vasculature adapts to insulin resistance through dilation and not angiogenesis
Vascular endothelial growth factor-A and islet vascularization are necessary in developing, but not adult, pancreatic islets
Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding
Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes β cell regeneration
De novo formation of insulin-producing neo-β cell islets from intestinal crypts
Plasmonic interferometric sensor arrays for high-performance label-free biomolecular detection
Single-cell analysis of K562 cells: An imatinib-resistant subpopulation is adherent and has upregulated expression of BCR-ABL mRNA and protein
Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma
Two-photon-triggered drug delivery via fluorescent nanovalves
Mouse liver repopulation with hepatocytes generated from human fibroblasts
Robust nonenzymatic hybrid nanoelectrocatalysts for signal amplification toward ultrasensitive electrochemical cytosensing
Magnetic field-induced T cell receptor clustering by nanoparticles enhances T cell activation and stimulates antitumor activity
Restoring visual function to blind mice with a photoswitch that exploits electrophysiological remodeling of retinal ganglion cells
A Photochromic Agonist for μ-Opioid Receptors
The ecology in the hematopoietic stem cell niche determines the clinical outcome in chronic myeloid leukemia
The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons
The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity
Application of platelet-rich plasma and platelet-rich fibrin in fat grafting: basic science and literature review
Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering
Central memory CD8+ T lymphocytes mediate lung allograft acceptance
Responses of Staphylococcus aureus bacterial cells to nanocrystalline nickel nanostructures
Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response
Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism
Activation of multiple signaling pathways during the differentiation of mesenchymal stem cells cultured in a silicon nanowire microenvironment
Imaging dynamic molecular signaling by the Cdc42 GTPase within the developing CNS
Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy
Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease
Neurons have an active glycogen metabolism that contributes to tolerance to hypoxia
Transgenerational transmission of hyperactivity in a mouse model of ADHD
Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in Fragile X Syndrome
MicroRNAs located in the hox gene clusters are implicated in Huntington's disease pathogenesis
Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial
Hsp90-tau complex reveals molecular basis for specificity in chaperone action
Cytoneme-mediated contact-dependent transport of the Drosophila decapentaplegic signaling protein
Topical application of PPADS inhibits complement activation and choroidal neovascularization in a model of age-related macular degeneration
Human iPSC-based modeling of late-onset disease via progerin-induced aging
Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice
Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation
Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling
An effective approach to prevent immune rejection of human ESC-derived allografts
Antagonism of CD11b with neutrophil inhibitory factor (NIF) inhibits vascular lesions in diabetic retinopathy
Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury
HIV-1 persistence in CD4+ T cells with stem celllike properties
Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin
Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue
Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors
Generation of iPSC lines from archived non-cryoprotected biobanked dura mater
Long-term stability and safety of transgenic cultured epidermal stem cells in gene therapy of junctional epidermolysis bullosa
Identification of novel human leukocyte antigen-A*0201-restricted, cytotoxic T lymphocyte epitopes on CD133 for cancer stem cell immunotherapy
Retinal detachment after open globe injury
Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial
Cellular resolution maps of X chromosome inactivation: implications for neural development, function, and disease
Patients attitudes toward the donation of biological materials for the derivation of induced pluripotent stem cells
Engineering cells with intracellular agentloaded microparticles to control cell phenotype
Synergy between multiple microtubule-generating pathways confers robustness to centrosome-driven mitotic spindle formation
Accurate prediction of drug-induced liver injury using stem cell-derived populations
Collaborative care outcomes for pediatric behavioral health problems: a cluster randomized trial
Early intervention to preempt major depression among older black and white adults
Testing Turings theory of morphogenesis in chemical cells
Novel processing of iron-manganese alloy-based biomaterials by inkjet 3-D printing
Human placental trophoblasts confer viral resistance to recipient cells
A randomized trial of protocol-based care for early septic shock
Human muscle-derived stem/progenitor cells promote functional murine peripheral nerve regeneration
Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication
Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus
Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1
Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits
Optogenetic stimulation of VTA dopamine neurons reveals that tonic but not phasic patterns of dopamine transmission reduce ethanol self-administration
Human RPE stem cells grown into polarized RPE monolayers on a polyester matrix are maintained after grafting into rabbit subretinal space
Autologous mesenchymal stromal cell infusion as adjunct treatment in patients with multidrug and extensively drug-resistant tuberculosis: an open-label phase 1 safety trial
Feasibility of repairing glomerular basement membrane defects in Alport Syndrome
Stem cell quiescence acts as a tumour suppressor in squamous tumours
Glycolytic ATP fuels the plasma membrane calcium pump critical for pancreatic cancer cell survival
Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
Human natural killer cells prevent infectious mononucleosis features by targeting lytic Epstein-Barr virus infection
Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
Transcriptional targeting of primary and metastatic tumor neovasculature by an adenoviral type 5 roundabout4 vector in mice
Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state
Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation
Wnt7b is an important intrinsic regulator of hair follicle stem cell homeostasis and hair follicle cycling
Adult rat retinal ganglion cells and glia can be printed by piezoelectric inkjet printing
A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring
Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce antitumor activity in solid malignancies
Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror
Epithelial-to-mesenchymal transition enhances the cardioprotective capacity of human amniotic epithelial cells
Targeting β-secretase with RNAi in neural stem cells for Alzheimer's disease therapy
Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers
Copper-transporting P-type ATPases use a unique ion-release pathway
Genome-wide transcriptional analysis of differentially expressed genes in diabetic, healing corneal epithelial cells: hyperglycemia-suppressed TGFβ3 expression contributes to the delay of epithelial wound healing in diabetic corneas
Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells
Silencing of RB1 and RB2/P130 during adipogenesis of bone marrow stromal cells results in dysregulated differentiation
Giant Vesicle Arrays: A Simple and Versatile Method for the Formation of Arrays of Giant Vesicles with Controlled Size and Composition
Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing
Long-term efficient gene delivery using polyethylenimine with modified Tat peptide
Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes
Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue
IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV
Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
Epithelial bridges maintain tissue integrity during collective cell migration
In vivo reprogramming of adult somatic cells to pluripotency by overexpression of Yamanaka factors
Co-culture with mesenchymal stem cells results in improved viability and function of human hepatocytes
Distinct fibroblast lineages determine dermal architecture in skin development and repair
Adding spatial control to click chemistry: phototriggered dielsalder surface (bio)functionalization at ambient temperature
(Bio)molecular surface patterning by phototriggered oxime ligation
Spatially controlled surface immobilization of nonmodified peptides
Spatially controlled surface immobilization of nucleophiles via trapping of photo-generated thioaldehydes
Three-dimensional microscaffolds exhibiting spatially resolved surface chemistry
Controlled cell adhesion on poly(dopamine) interfaces photopatterned with non-fouling brushes
Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells
Salmonella Typhimurium impedes innate immunity with a mast-cell-suppressing protein tyrosine phosphatase, SptP
Pre- and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis imperfecta: a two-center experience
Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein-Barr Virus latent membrane proteins
Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies
Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA
Its time to bring dendritic cell therapy to type 1 diabetes
Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of Alpha-1-antitrypsin deficiency
Electrically controlled drug delivery from graphene oxide nanocomposite films
Decellularized allogeneic and xenogeneic tissue as a bioscaffold for regenerative medicine: factors that influence the host response
Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer
Biologically derived melanin electrodes in aqueous sodium-ion energy storage devices
Reaction-based fluorescent sensor for investigating mobile Zn2+ in mitochondria of healthy versus cancerous prostate cells
Marker-free phenotyping of tumor cells by fractal analysis of reflection interference contrast microscopy images
Quantifying cell-generated mechanical forces within living embryonic tissues
Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation
Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A
PKM2 regulates chromosome segregation and mitosis progression of tumor cells
Antiviral treatment for hepatitis C virus infection is associated with improved renal and cardiovascular outcomes in diabetic patients
Transcranial amelioration of inflammation and cell death after brain injury
Mapping eQTLs in the Norfolk Island genetic isolate identifies candidate genes for CVD risk traits
Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy
Motor excitability during movement preparation in Tourette syndrome
In vivo performance of a drug-eluting contact lens to treat glaucoma for a month
A special population of regulatory T cells potentiates muscle repair
Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis
Histology of CorMatrix bioscaffold 5 Years after pericardial closure
APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation
Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo
Strategies for expanding the operational range of channelrhodopsin in optogenetic vision
Structural basis for Ca2+ selectivity of a voltage-gated calcium channel
Nanowell-trapped charged ligand-bearing nanoparticle surfaces: a novel method of enhancing flow-resistant cell adhesion
c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface
Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny
Sca1-derived cells are a source of myocardial renewal in the murine adult heart
Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment
Efficient generation of lung and airway epithelial cells from human pluripotent stem cells
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation
Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure
Characterization of a biodegradable coralline hydroxyapatite/calcium carbonate composite and its clinical implementation
Microbial colonization influences early B-lineage development in the gut lamina propria
Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration
EMRE is an essential component of the mitochondrial calcium uniporter complex
Deficits in adult neurogenesis, contextual fear conditioning, and spatial learning in a Gfap mutant mouse model of Alexander disease
Metabolically active human brown adipose tissue derived stem cells
Mitochondrial retrograde signaling induces epithelialmesenchymal transition and generates breast cancer stem cells
Human Treg responses allow sustained recombinant adeno-associated virusmediated transgene expression
Design and formulation of functional pluripotent stem cell-derived cardiac microtissues
HiRIEF LC-MS enables deep proteome coverage and unbiased proteogenomics
The presenilin-1 ΔE9 mutation results in reduced -γsecretase activity, but not total loss of PS1 function, in isogenic human stem cells
Chromosomal contact permits transcription between coregulated genes
Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells
Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering
Ultrasound-triggered regulation of blood glucose levels using injectable nano-network
CD137 accurately identifies and enriches for naturally-occurring tumor-reactive T cells in tumor
Beta cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome
Activated ClpP kills persisters and eradicates a chronic biofilm infection
The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites
Parvalbumin interneurons mediate neuronal circuitryneurogenesis coupling in the adult hippocampus
Tension-oriented cell divisions limit anisotropic tissue tension in epithelial spreading during zebrafish epiboly
SERCA2a controls the mode of agonist-induced intracellular Ca2+ signal, transcription factor NFAT and proliferation in human vascular smooth muscle cells
SUMO1-dependent modulation of SERCA2a in heart failure
SUMO-1 gene transfer improves cardiac function in a large-animal model of heart failure
The cytotoxic necrotizing factor of Yersinia pseudotuberculosis (CNFY) enhances inflammation and Yop delivery during infection by activation of Rho GTPases
Psychobiotics: a novel class of psychotropic
Two-wave nanotherapy to target the stroma and optimize gemcitabine delivery to a human pancreatic cancer model in mice
JUNB/AP-1 controls IFN-γ during inflammatory liver disease
Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery
Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma
Sorafenib/regorafenib and phosphatidyl inositol 3 kinase/thymoma viral proto-oncogene inhibition interact to kill tumor cells
Intravenous multipotent adult progenitor cell therapy attenuates activated microglial/macrophage response and improves spatial learning after traumatic brain injury
Computed tomography-guided tissue engineering of equine upper airway cartilage
Nanotechnology in the regulation of stem cell behavior
Exome sequencing identifies distinct mutational patterns in liver flukerelated and non-infection-related bile duct cancers
Enrichment of human prostate cancer cells with tumor initiating properties in mouse and zebrafish xenografts by differential adhesion
Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis
Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis
Autologous transplantation as consolidation for aggressive non-hodgkin's lymphoma
Differentiated kidney epithelial cells repair injured proximal tubule
Plasmapheresis eliminates the negative impact of AAV antibodies on micro-dystrophin gene expression following vascular delivery
A genetic and developmental pathway from STAT3 to the OCT4NANOG circuit is essential for maintenance of ICM lineages in vivo
Fiber-optic two-photon optogenetic stimulation
Identification and rescue of α-synuclein toxicity in Parkinson patientderived neurons
Yeast reveal a druggable Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons
Protein phosphatase 4 and Smek complex negatively regulate Par3 and promote neuronal differentiation of neural stem/progenitor cells
Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency
Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease
Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment
High-throughput fingerprinting of human pluripotent stem cell fate responses and lineage bias
Targeted deletion of Vegfa in adult mice induces vision loss
Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting
Quantitative transcriptomics using designed primer-based amplification
Harnessing interfacially-active nanorods to regenerate severed polymer gels
Genome-wide association study of obsessive-compulsive disorder
Genome-wide association study of Tourette's syndrome
Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture
Failure of stem cell therapy to improve visual acuity in children with optic nerve hypoplasia
Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation
Positional information is reprogrammed in blastema cells of the regenerating limb of the Axolotl (Ambystoma mexicanum)
Molecular mechanisms of cellular mechanosensing
Magneto-electric nanoparticles to enable field-controlled high-specificity drug delivery to eradicate ovarian cancer cells
Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion
Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury
Biophysical regulation of epigenetic state and cell reprogramming
A nanopore machine promotes the vectorial transport of DNA across membranes
SCRIB and PUF60 are primary drivers of the multisystemic phenotypes of the 8q24.3 copy-number variant
Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury
Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults
Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects
Relationship between 17-alpha hydroxyprogesterone caproate concentration and spontaneous preterm birth
Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity
Smurf2 regulates the senescence response and suppresses tumorigenesis in mice
Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1
Multifunctional nanomedicine platform for concurrent delivery of chemotherapeutic drugs and mild hyperthermia to ovarian cancer cells
Lower HIV provirus levels are associated with more APOBEC3G protein in blood resting memory CD4+ T lymphocytes
Dielectrophoresis-based discrimination of bacteria at the strain level based on their surface properties
Early outgrowth cells release soluble endocrine anti-fibrotic factors that reduce progressive organ fibrosis
Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity
DGIdb: mining the druggable genome
Genome-wide sequencing of cellular microRNAs identifies a combinatorial expression signature diagnostic of sepsis
RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention
SLIT3ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo
Cytoplasmic genetic variation and extensive cytonuclear interactions influence natural variation in the metabolome
Automatic diagnosis of pathological myopia from heterogeneous biomedical data
Identification of neural connectivity signatures of autism using machine learning
Spatial organization within a niche as a determinant of stem-cell fate
Differentiated troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium
Sustained release of bone morphogenetic protein 2 via coacervate improves the osteogenic potential of muscle-derived stem cells
Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes
Sox2+ stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential
Induction and suppression of RNA silencing by an animal virus
Antiviral RNA interference in mammalian cells
RNA interference functions as an antiviral immunity mechanism in mammals
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome
DNMT1-interacting RNAs block gene-specific DNA methylation
Spontaneous lytic replication and epitheliotropism define an Epstein-Barr virus strain found in carcinomas
Retinal proteome alterations in a mouse model of type 2 diabetes
Klotho regulates retinal pigment epithelial functions and protects against oxidative stress
Mammalian cells preferentially internalize hydrogel nanodiscs over nanorods and use shape-specific uptake mechanisms
An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level
Aberrant dolichol chain lengths as biomarkers for retinitis pigmentosa caused by impaired dolichol biosynthesis
The housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) regulates multiple developmental and metabolic pathways of murine embryonic stem cell neuronal differentiation
Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors
5-HT2 receptors facilitate JC polyomavirus entry
Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors
Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance
Integrative annotation of variants from 1092 humans: application to cancer genomics
Addiction of t(8;21) and inv(16) acute myeloid leukemia to native RUNX1
Dendritic epidermal T cells regulate skin antimicrobial barrier function
Defining cell-type specificity at the transcriptional level in human disease
How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function
Simple, inexpensive technique for high-quality Smartphone fundus photography in human and animal eyes
Identifying division symmetry of mouse embryonic stem cells: negative impact of DNA methyltransferases on symmetric self-renewal
Directional tissue migration through a self-generated chemokine gradient
Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a nonhuman primate
CMX001 to prevent cytomegalovirus disease in hematopoietic-cell transplantation
Pan-cancer patterns of somatic copy number alteration
Paneth cells as a site of origin for intestinal inflammation
mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation
With an eye to low vision: optic flow enables perception despite image blur
The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch
Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload
Early human prostate adenocarcinomas harbor androgen-independent cancer cells
Deterministic direct reprogramming of somatic cells to pluripotency
Helicobacter pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses
Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1
Scalable spray deposition process for high-performance carbon nanotube gas sensors
Flexible carbon nanotube based gas sensors fabricated by large-scale spray deposition
Fabrication of carbon nanotube thin films on flexible substrates by spray deposition and transfer printing
Glassy dynamics in three-dimensional embryonic tissues
Targeting sonic hedgehog-associated medulloblastoma through inhibition of aurora and polo-like kinases
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
Generation of effector memory T cellbased mucosal and systemic immunity with pulmonary nanoparticle vaccination
Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota
Whole genome sequencing in patients with retinitis pigmentosa reveals pathogenic DNA structural changes and NEK2 as a new disease gene
Smart-seq2 for sensitive full-length transcriptome profiling in single cells
Biochemical and physical signal gradients in hydrogels to control stem cell behavior
Single-cell Hi-C reveals cell-to-cell variability in chromosome structure
Multifocal pupillography identifies retinal dysfunction in early age-related macular degeneration
Macrophage phenotype in the mammary gland fluctuates over the course of the estrous cycle and is regulated by ovarian steroid hormones
Hippocampal interneuron transplants reverse aberrant dopamine system function and behavior in a rodent model of schizophrenia
Reprogramming in vivo produces teratomas and iPS cells with totipotency features
Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival
CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance
Usp16 contributes to somatic stem-cell defects in Downs syndrome
Initiation of GalNAc-type O-glycosylation in the endoplasmic reticulum promotes cancer cell invasiveness
Network-based stratification of tumor mutations
Activated EGFR stimulates MUC1 expression in human uterine and pancreatic cancer cell lines
An experimental test on the probability of extinction of new genetic variants
Retinal angiogenesis suppression through small molecule activation of p53
Identification of a rare coding variant in complement 3 associated with age-related macular degeneration
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity
SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells
Human circulating PD-1+CXCR3CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses
Physical clustering of FLC alleles during Polycomb-mediated epigenetic silencing in vernalization
Early role for IL-6 signalling during generation of induced pluripotent stem cells revealed by heterokaryon RNA-Seq
Superpixel classification based optic disc and optic cup segmentation for glaucoma screening
Age of the donor reduces the ability of human adipose-derived stem cells to alleviate symptoms in the experimental autoimmune encephalomyelitis mouse model
Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene
Genome engineering of drosophila with the CRISPR RNA-guided Cas9 nuclease
Effects of sleep and wake on oligodendrocytes and their precursors
Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma
Cellular and synaptic architecture of multisensory integration in the mouse neocortex
Functional consequences of platelet binding to T lymphocytes in inflammation
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomised placebo-controlled trial
Adipose stem cell therapy for soft tissue reconstruction
Technology, trends, and the future for people with spinal cord injury
The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis
Probing red blood cell morphology using high-frequency photoacoustics
In vitro study of α-synuclein protofibrils by cryo-EM suggests a Cu2+-dependent aggregation pathway
Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation
Increasing the complexity of chromatin: functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis
Stomach cancer risk after treatment for Hodgkin lymphoma
Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)
Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas
Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function
Induced pluripotent stem cell intervention rescues ventricular wall motion disparity, achieving biological cardiac resynchronization post-infarction
In situ regulation of DC subsets and T cells mediates tumor regression in mice
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
Purification of cardiomyocytes from differentiating pluripotent stem cells using molecular beacons targeting cardiomyocyte-specific mRNA
Migraine and structural changes in the brain: A systematic review and meta-analysis
Genetic basis for in vivo daptomycin resistance in enterococci
Daptomycin-resistant Enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids
Chemoprevention of prostate cancer by D,L-sulforaphane is augmented by pharmacological inhibition of autophagy
Blocking macrophage leukotriene B4 prevents endothelial injury and reverses pulmonary hypertension
What can information-asymmetric games tell us about the context of Crick's frozen accident?
Topoisomerases facilitate transcription of long genes linked to autism
Self-assembled carbon nanotube honeycomb networks using a butterfly wing template as a multifunctional nanobiohybrid
GATA-3 regulates the self-renewal of long-term hematopoietic stem cells
Low-dose food contaminants trigger sex-specific, hepatic metabolic changes in the progeny of obese mice
Two cells are better than one: Optimizing stem cell survival by co-grafting helper cells that offer regulated trophic support
Neural progenitor cell survival in mouse brain can be improved by co-transplantation of helper cells expressing bFGF under doxycycline control
Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53
Generation and characterization of spiking and non-spiking oligodendroglial progenitor cells from embryonic stem cells
Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48
PET/MRI: applications in clinical imaging
Richness of human gut microbiome correlates with metabolic markers
Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity
A new role for histone deacetylase 5 in the maintenance of long telomeres
Potential protective effect of biphasic electrical stimulation against growth factor-deprived apoptosis on olfactory bulb neural progenitor cells through the brain-derived neurotrophic factorphosphatidylinositol 3′-kinase/Akt pathway
Cerebral organoids model human brain development and microcephaly
IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses
A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
Global comparisons of lectin-glycan interactions using a database of analyzed glycan array data
Specific glycoforms of MUC5AC and endorepellin accurately distinguish mucinous from non-mucinous pancreatic cysts
Marine omega-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behaviour and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD
Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia
Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide
Transplantation of human fetal-derived neural stem cells improves cognitive function following cranial irradiation
Deacetylase inhibition promotes the generation and function of regulatory T cells
Inhibition of p300 impairs Foxp3+ T regulatory cell function and promotes antitumor immunity
Patterned prevascularised tissue constructs by assembly of polyelectrolyte hydrogel fibres
Functional vascular endothelium derived from human induced pluripotent stem cells
Fruit and vegetable intakes are associated with lower risk of bladder cancer among women in the multiethnic cohort study
A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment
Molecular crowding shapes gene expression in synthetic cellular nanosystems
Mortality among patients admitted to strained intensive care units
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes
Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state
Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells
Mesenchymal stem cells enhance the engraftment and myelinating ability of allogeneic oligodendrocyte progenitors in dysmyelinated mice
Clinical and pathological effects of intrathecal injection of mesenchymal stem cell-derived neural progenitors in an experimental model of multiple sclerosis
Characterization of autologous mesenchymal stem cell-derived neural progenitors as a feasible source of stem cells for central nervous system applications in multiple sclerosis
Cerebrospinal fluid derived from progressive multiple sclerosis patients promotes neuronal and oligodendroglial differentiation of human neural precursor cells in vitro
Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis
MC1R is a potent regulator of PTEN after UV exposure in melanocytes
Population-based prognostic factors for survival in patients with Burkitt lymphoma: An analysis from the Surveillance, Epidemiology, and End Results database
Bacteria activate sensory neurons that modulate pain and inflammation
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitides
Muscle cells provide instructions for planarian regeneration
T follicular helper cell dynamics in germinal centers
Signatures of mutational processes in human cancer
Pediatric intestinal failureassociated liver disease is reversed with 6 months of intravenous fish oil
The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells
Polymalic acid nanobioconjugate for simultaneous immunostimulation and inhibition of tumor growth in HER2/neu-positive breast cancer
SCHEMA computational design of virus capsid chimeras: calibrating how genome packaging, protection, and transduction correlate with calculated structural disruption
Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy
Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection
Adult c-kitpos cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair
ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death
Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases
Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration
De novo mutations in epileptic encephalopathies
Molecular profiling supports the role of epithelial-to-mesenchymal transition (EMT) in ovarian cancer metastasis
Paternally expressed genes predominate in the placenta
The epidermis comprises autonomous compartments maintained by distinct stem cell populations
Onecut1 is essential for horizontal cell genesis and retinal integrity
Low CSF concentration of mitochondrial DNA in preclinical Alzheimer's disease
Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs
Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: Metabolic and immunologic features at baseline identify a subgroup of responders
Nano-imprinting lithography of P(VDFTrFECFE) for flexible freestanding MEMS devices
Obstructive sleep apnea and increased risk of glaucoma: a population-based matched-cohort study
Single-cell optoporation and transfection using femtosecond laser and optical tweezers
Rheumatoid arthritis increases the risk of deep vein thrombosis and pulmonary thromboembolism: a nationwide cohort study
Low-frequency (<100 kHz), low-intensity (<100 mW/cm2) ultrasound to treat venous ulcers: A human study and in vitro experiments
Spatial dynamics of chromosome translocations in living cells
Connectomic reconstruction of the inner plexiform layer in the mouse retina
Relationship between dry eye symptoms and pain sensitivity
Gingivae contain neural-crest- and mesoderm-derived mesenchymal stem cells
Epoxyeicosanoids promote organ and tissue regeneration
Efficient generation of human iPSCs by a synthetic self-replicative RNA
Transforming fusions of FGFR and TACC genes in human glioblastoma
The integrated landscape of driver genomic alterations in glioblastoma
Localization of magnetic pills
Can bioadhesive nanoparticles allow for more effective particle uptake from the small intestine?
Oral delivery of proteins by biodegradable nanoparticles
Unique insights into the intestinal absorption, transit, and subsequent biodistribution of polymer-derived microspheres
Regional localization within the bone marrow influences the functional capacity of human HSCs
SIGIRR, a negative regulator of TLR/IL-1R signalling promotes microbiota dependent resistance to colonization by enteric bacterial pathogens
Creating a false memory in the hippocampus
AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency gene
Increased sphingosine-1-phosphate improves muscle regeneration in acutely injured mdx mice
Combined alloreactive CTL cellular therapy with prodrug activator gene therapy in a model of breast cancer metastatic to the brain
A cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells
Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension
14-step synthesis of (+)-Ingenol from (+)-3-Carene
Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial
Adolescent behavior and dopamine availability are uniquely sensitive to dietary omega-3 fatty acid deficiency
The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance Imatinib-induced apoptosis
Motile axonal mitochondria contribute to the variability of presynaptic strength
Green biosynthesis of gold nanometre scale plates using the leaf extracts from an indigenous Australian plant Eucalyptus macrocarpa
The conditional nature of genetic interactions: the consequences of wild-type backgrounds on mutational interactions in a genome-wide modifier screen
Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation
Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells
Extended practice of a motor skill is associated with reduced metabolic activity in M1
Modeling the photoinduced reconfiguration and directed motion of polymer gels
hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury
Alzheimers disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production
Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion
Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia
Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients
Single molecular hyperbranched nanoprobes for fluorescence and magnetic resonance dual modal imaging
Correction of diabetic hyperglycemia and amelioration of metabolic anomalies by minicircle DNA mediated glucose-dependent hepatic insulin production
Interkinetic nuclear migration is a broadly conserved feature of cell division in pseudostratified epithelia
Epithelial junctions maintain tissue architecture by directing planar spindle orientation
Activated carbon cloth as support for mesenchymal stem cell growth and differentiation to osteocytes
Human umbilical cord stromal stem cell express CD10 and exert contractile properties
The importance of bystander effects in radiation therapy in melanoma skin-cancer cells and umbilical-cord stromal stem cells
Growth and spontaneous differentiation of umbilical-cord stromal stem cells on activated carbon cloth
Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix
Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis
Label-free detection of single protein using a nanoplasmonic-photonic hybrid microcavity
Optical control of mammalian endogenous transcription and epigenetic states
Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism
Premature cell senescence and T cell receptorindependent activation of CD8+ T cells in juvenile idiopathic arthritis
Reactivating head regrowth in a regeneration-deficient planarian species
Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells
Myeloid/microglial driven autologous hematopoietic stem cell gene therapy corrects a neuronopathic lysosomal disease
TGFβ receptor mutations impose a strong predisposition for human allergic disease
Gingivae contain neural-crest- and mesoderm-derived mesenchymal stem cells
Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells
Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development
Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina
Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease
Overcoming preexisting humoral immunity to AAV using capsid decoys
The antagonistic modulation of Arp2/3 activity by N-WASP/WAVE2 and PICK1 defines dynamic changes in astrocyte morphology
Special section guest editorial: optical methods of imaging in the skin
Translating dosage compensation to trisomy 21
Wnt/β-catenin signaling triggers neuron reprogramming and regeneration in the mouse retina
LRG1 promotes angiogenesis by modulating endothelial TGF-β signaling
Molecular crowding shapes gene expression in synthetic cellular nanosystems
Prospective randomized clinical evaluation of conventional single-bundle, anatomic single-bundle, and anatomic double-bundle anterior cruciate ligament reconstruction: 281 cases with 3- to 5-year follow-up
Transient B cell depletion combined with apoptotic donor splenocytes induces xeno-specific T and B cell tolerance to islet xenografts
Nanoengineering gold particle composite fibers for cardiac tissue engineering
TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transfer
Noncanonical autophagy promotes the visual cycle
Disturbed sleep and inflammatory cytokines in depressed and nondepressed pregnant women: an exploratory analysis of pregnancy outcomes
Systemic delivery of SapC-DOPS has antiangiogenic and antitumor effects against glioblastoma
Lentiviral hematopoietic stem cell gene therapy benefits Metachromatic Leukodystrophy
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich Syndrome
Passive joint forces are tuned to limb use in insects and drive movements without motor activity
SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice
Heart grafts tolerized through third-party multipotent adult progenitor cells can be retransplanted to secondary hosts with no immunosuppression
Magnetic targeting of human mesenchymal stem cells with internalized superparamagnetic iron oxide nanoparticles
Positive feedback between PU.1 and the cell cycle controls myeloid differentiation
Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity
Insulin and IGF1 modulate turnover of polysialylated neuronal cell adhesion molecule (PSA-NCAM) in a process involving specific extracellular matrix components
Reprogramming to pluripotency using designer TALE transcription factors targeting enhancers
Iron administration before stem cell harvest enables MR imaging tracking after transplantation
DNA computation in mammalian cells: microRNA logic operations
In vivo cardiac reprogramming contributes to zebrafish heart regeneration
Tunable touch sensor and combined sensing platform: toward nanoparticle-based electronic skin
A microparticle approach to morphogen delivery within pluripotent stem cell aggregates
Cell-based therapy for ischemic stroke
Engineered neural tissue for peripheral nerve repair
Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3′ UTRs
eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich Syndrome
Reversal of succinylcholine induced apnea with an organophosphate scavenging recombinant butyrylcholinesterase
Chemical communication of antibiotic resistance by a highly resistant subpopulation of bacterial cells
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming
Global epigenomic reconfiguration during mammalian brain development
Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation
Human placental trophoblasts confer viral resistance to recipient cells
Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay
Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events
5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint
Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children
Switchable telescopic contact lens
β-globin gene transfer to human bone marrow for sickle cell disease
Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy
Transplantation of autologous olfactory ensheathing cells in complete human spinal cord injury
A comprehensive assessment of gait accelerometry signals in time, frequency and time-frequency domains
In vitro integration of ribosomal RNA synthesis, ribosome assembly, and translation
Influence of surface features on the adhesion of Staphyloccocus epidermidis to AgTiCN thin films
Neurons within the same network independently achieve conserved output by differentially balancing variable conductance magnitudes
The relationship between diabetic retinopathy and cognitive impairment
Efficacy and safety of autologous bone marrow derived stem cell transplantation in patients with type 2 diabetes mellitus: a randomized placebo-controlled study
Rapid detection of bacterial resistance to antibiotics using AFM cantilevers as nanomechanical sensors
Regulatory dendritic cell infusion prolongs kidney allograft survival in nonhuman primates
Wnt activation in nail epithelium couples nail growth to digit regeneration
Gold nanorod vaccine for respiratory syncytial virus
Dapper antagonist of Catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain
Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntingtons Disease
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes
An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression
Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells
Combinatorial temporal patterning in progenitors expands neural diversity
A largely random AAV integration profile after LPLD gene therapy
Scalable nano-bioprobes with sub-cellular resolution for cell detection
MEK inhibitors selectively suppress alloreactivity and graft-versus-host disease in a memory stage-dependent manner
iPSC-derived β cells model diabetes due to glucokinase deficiency
Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis
Role of reduced-intensity conditioning allogeneic hematopoietic stem-cell transplantation in older patients with de novo myelodysplastic syndromes: an international collaborative decision analysis
Self-organization of bacterial biofilms is facilitated by extracellular DNA
Intravital FLIM-FRET imaging reveals dasatinibinduced spatial control of Src in pancreatic cancer
Awakened by cellular stress: isolation and characterization of a novel population of pluripotent stem cells derived from human adipose tissue
Pericytes derived from adipose-derived stem cells protect against retinal vasculopathy
In vivodirected evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous
Antigen-specific tolerance by autologous myelin peptidecoupled cells: a phase 1 trial in multiple sclerosis
Posttranscriptional control of T cell effector function by aerobic glycolysis
Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells
Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding
KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development
InVERT molding for scalable control of tissue microarchitecture
Geometric control of vascular networks to enhance engineered tissue integration and function
Identification of small molecules for human hepatocyte expansion and iPS differentiation
Mediation of protection and recovery from experimental autoimmune encephalomyelitis by macrophages expressing the human voltage-gated sodium channel NaV1.5
Intranasal antibody gene transfer in mice and ferrets elicits broad protection against pandemic influenza
Hypothermic storage of human hepatocytes for transplantation
Stepwise evolution of essential centromere function in a Drosophila neogene
Phase I/II trial of adeno-associated virusmediated alpha-glucosidase gene therapy to the diaphragm for chronic respiratory failure in pompe disease: initial safety and ventilatory outcomes
Targeting of the MNKeIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function
The perivascular niche regulates breast tumour dormancy
Identification of unsafe human induced pluripotent stem cell lines using a robust surrogate assay for pluripotency
WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs
11β-hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects
Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation
A preclinical xenograft model identifies castration-tolerant cancer-repopulating cells in localized prostate tumors
Recovery from overt type 1 diabetes ensues when immune tolerance and β cell formation are coupled with regeneration of endothelial cells in the pancreatic islets
Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model
Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP
High-performance, transparent, and stretchable electrodes using graphenemetal nanowire hybrid structures
Significant improvement in survival after allogeneic hematopoietic cell transplantation during a period of significantly increased use, older recipient age, and use of unrelated donors
CD4+CD73+ T cells are associated with lower T-cell activation and C reactive protein levels and are depleted in HIV-1 infection regardless of viral suppression
Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus
Nanoclays mediate stem cell differentiation and mineralized ECM formation on biopolymer scaffolds
Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics
An RNA aptamer provides a novel approach for the induction of apoptosis by targeting the HPV16 E7 oncoprotein
The role of gene therapy in regenerative surgery: updated insights
Estrogen reduces lipid content in the liver exclusively from membrane receptor signaling
Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies
Targeting immunosuppression for cancer therapy
Depleting tumor-specific Tregs at a single site eradicates disseminated tumors
Risk of cancer among workers exposed to trichloroethylene: analysis of three nordic cohort studies
First autologous cell therapy of cerebral palsy caused by hypoxic-ischemic brain damage in a child after cardiac arrestindividual treatment with cord blood
Percutaneous tibial nerve stimulation for the long-term treatment of overactive bladder: 3-year results of the STEP study
Structural basis of actin filament nucleation by tandem W domains
Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers
Adipose tissue-derived multipotent stromal cells have a higher immunomodulatory capacity than their bone marrow-derived counterparts
Zwitterionic hydrogels implanted in mice resist the foreign-body reaction
Matrix metalloproteinase-8 (collagenase-2) induces the expression of interleukins-6 and -8 in breast cancer cells
Bioresorbable airway splint created with a three-dimensional printer
Defining single molecular forces required to activate integrin and Notch signaling
Identification of candidate genes encoding an LDL-C QTL in baboons
Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis
Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response
Do findings on routine examination identify patients at risk for primary open-angle glaucoma?
Comment on ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning
A molecular roadmap of reprogramming somatic cells into iPS cells
Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids
Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation
VEGF induces TGF-β1 expression and myofibroblast transformation after glaucoma surgery
SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs
Hybrid equation/agent-based model of ischemia-induced hyperemia and pressure ulcer formation predicts greater propensity to ulcerate in subjects with spinal cord injury
Epigenomic analysis of multilineage differentiation of human embryonic stem cells
Young at heart
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later
Agent Orange as a risk factor for high-grade prostate cancer
Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development
Prefrontal microcircuit underlies contextual learning after hippocampal loss
Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes
Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria
Human embryonic stem cells derived by somatic cell nuclear transfer
Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients
Three-dimensional hydrogel constructs for exposing cells to nanoparticles
Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia
Cognate antigen directs CD8+ T cell migration to vascularized transplants
Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain
Engineering bone tissue substitutes from human induced pluripotent stem cells
Linear mesostructures in DNAnanorod self-assembly
Multicenter study of banked third party virus-specific T-cells to treat severe viral infections after hematopoietic stem cell transplantation
Nonmelanoma skin cancer is associated with reduced Alzheimer disease risk
Chromosome-specific nonrandom sister chromatid segregation during stem-cell division
Prospective evaluation of a molecular marker panel for prediction of recurrence and cancer-specific survival after radical cystectomy
SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
Epigenetic activation of AP1 promotes squamous cell carcinoma metastasis
Psl trails guide exploration and microcolony formation in Pseudomonas aeruginosa biofilms
Role of pericytes in skeletal muscle regeneration and fat accumulation
Long-term effects of vitamins C and E, β-carotene, and zinc on age-related macular degeneration: AREDS report no. 35
Lutein/Zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4
Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial
Highly elastic micropatterned hydrogel for engineering functional cardiac tissue
Evidence for a common mechanism of SIRT1 regulation by allosteric activators
A role for PVRL4-driven cellcell interactions in tumorigenesis
Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development
GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior
Liver preservation with machine perfusion under full oxygenation using a new cell-free oxygen-carrier solution
Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog
Roles of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice
3D printed bionic ears
Chitosan/poly(vinyl alcohol) hydrogel combined with Ad-hTGF-β1 transfected mesenchymal stem cells to repair rabbit articular cartilage defects
Generation of integration-free and region-specific neural progenitors from primate fibroblasts
Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila
The dual role of mesenchymal stem cells in tumor progression
The dual effect of mscs on tumour growth and tumour angiogenesis
MicroRNA-382 expression is elevated in the olfactory neuroepithelium of schizophrenia patients
Symptom severity predicts prolonged recovery after sport-related concussion, but age and amnesia do not
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimers disease
Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis
Screening of biochemical and molecular mechanisms of secondary injury and repair in the brain after experimental blast-induced traumatic brain injury in rats
Bone marrow tinctures for cardiovascular disease: lost in translation
Intracoronary injection of bone marrow derived mononuclear cells, early or late after acute myocardial infarction: effects on global left ventricular function four months results of the SWISS-AMI trial
Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOSNOnitrite signaling
Late-life depression and risk of vascular dementia and Alzheimers disease: systematic review and meta-analysis of community-based cohort studies
Generation of oligodendroglial cells by direct lineage conversion
Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis
Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer
Effect of shock wavefacilitated intracoronary cell therapy on LVEF in patients with chronic heart failure
Regulation of stem cell therapies under attack in Europe: for whom the bell tolls
A physical sciences network characterization of non-tumorigenic and metastatic cells
A systematic genome-wide analysis of zebrafish protein-coding gene function
Medial ganglionic eminencelike cells derived from human embryonic stem cells correct learning and memory deficits
Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration
Transcription factormediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells
Regeneration and experimental orthotopic transplantation of a bioengineered kidney
Intranasal delivery of pGDNF nanoparticles provides neuroprotection in the rat 6-hydroxydopamine model of Parkinsons disease
Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors
Lower baseline prostate-specific antigen is associated with a greater overall survival benefit from sipuleucel-T in the Immunotherapy for Prostate Adenocarcinoma Treatment (IMPACT) trial
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
Transcription factormediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells
Cardiopoietic stem cell therapy in heart failure The C-CURE multicenter randomized trial with lineage-specified biologics
Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration
Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon
Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model
Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial
CD24 and CD44 mark human intestinal epithelial cell populations with characteristics of active and facultative stem cells
Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells
Micromanaging hepatitis C virus
Treatment of HCV infection by targeting microRNA
Amplifying genetic logic gates
Rational design of a ligand-controlled protein conformational switch
Optically triggering spatiotemporally confined GPCR activity in a cell and programming neurite initiation and extension
Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration
Tissue engineering and regenerative medicine: recent innovations and the transition to translation
Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice
Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia
A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation
An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study
Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels
Autophagy in stem cells
FIP200 is required for maintenance and differentiation of postnatal neural stem cells
Mesenchymal stem cells engineered to inhibit complement-mediated damage
Stromal cell identity influences the in vivo functionality of engineered capillary networks formed by co-delivery of endothelial cells and stromal cells
Cellular and molecular basis of von Willebrand disease: studies on blood outgrowth endothelial cells
Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking
Intracellular aggregation of multimodal silica nanoparticles for ultrasound-guided stem cell implantation
Improved methods for reprogramming human dermal fibroblasts using fluorescence activated cell sorting
The circadian clock gates the intestinal stem cell regenerative state
Adhesion strengthbased, label-free isolation of human pluripotent stem cells
Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease specific patterns of cardiotoxicity
Keratocyte fragments and cells utilize competing pathways to move in opposite directions in an electric field
Assembly of complex cell microenvironments using geometrically docked hydrogel shapes
Chimeric antigen receptor T cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo
Laparoscopic pyeloplasty for ureteropelvic junction obstruction in infants
Cell-based therapeutics: the next pillar of medicine
CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
Regulation of stem cell fate in a three-dimensional micropatterned dual-crosslinked hydrogel system
A tissue-like printed material
Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4
Transgenic overexpression of ribonucleotide reductase improves cardiac performance
The human placenta methylome
Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44
Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons
Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo
A human pancreatic beta cell G1/S molecule cell cycle atlas
Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human beta cell replication: a revised model of human beta cell G1/S control
An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state
Generation of induced neurons via direct conversion in vivo
Self-deployable current sources fabricated from edible materials
Inflammatory bowel disease
Nonxenogeneic growth and retinal differentiation of human induced pluripotent stem cells
A localized Wnt signal orients asymmetric stem cell division in vitro
Disparate individual fates compose robust CD8+ T cell immunity
A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells
Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy
Four-part leukocyte differential count based on sheathless microflow cytometer and fluorescent dye assay
Genes for endosomal NHE6 and NHE9 are misregulated in autism brains
Induced pluripotent stem cell-derived neural cells survive and mature in the nonhuman primate brain
Temperature sculpting in yoctoliter volumes
Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology
Secondary T cellT cell synaptic interactions drive the differentiation of protective CD8+ T cells
Cytolytic nanoparticles attenuate HIV-1 infectivity
Targeting the intracellular WT1 oncogene product with a therapeutic human antibody
The human gene connectome as a map of short cuts for morbid allele discovery
Novel higher-order epigenetic regulation of the Bdnf gene upon seizures
EBF2 determines and maintains brown adipocyte identity
Synaptic plasticity by antidromic firing during hippocampal network oscillations
Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors
Rab11 regulates cellcell communication during collective cell movements
Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression
Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF
Mesenchymal stem cells derived from adipose tissue vs bone marrow: in vitro comparison of their tropism towards gliomas
Stromal cell-derived factor-1β mediates cell survival through enhancing autophagy in bone marrow-derived mesenchymal stem cells
A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy
Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci
Outcomes of transplantation using various hematopoietic cell sources in children with Hurler's syndrome after myeloablative conditioning
Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier
Dextran and protamine-based solid lipid nanoparticles as potential vectors for the treatment of X-linked juvenile retinoschisis
Interplay of LRRK2 with chaperone-mediated autophagy
Combination treatment of stroke with sub-therapeutic doses of Simvastatin and human umbilical cord blood cells enhances vascular remodeling and improves functional outcome
Improvement in poor graft function after allogeneic hematopoietic stem cell transplantation upon administration of mesenchymal stem cells from third-party donors: a pilot prospective study
Autologous bone marrow-derived cell therapy combined with physical therapy induces functional improvement in chronic spinal cord injury patients
Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future
See-saw expression of microRNA-198 and FSTL1 from a single transcript in wound healing
Topical administration of allogeneic mesenchymal stem cells seeded in a collagen scaffold augments wound healing and increases angiogenesis in the diabetic rabbit ulcer
Complement factor H variant increases the risk of age-related macular degeneration
Seven new loci associated with age-related macular degeneration
Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration
Relationship of age and body mass index to the expression of obesity and osteoarthritis-related genes in human meniscus
Lipid metabolism genes in contralateral unaffected breast and estrogen receptor status of breast cancer
Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds
Cell-free protein synthesis and assembly on a biochip
Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice
Independent category and spatial encoding in parietal cortex
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells