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2nd thread in a series?
Well, here it is: The last several versions of Diskeeper have left me a little bit disappointed. First off, let me be clear: Diskeeper is still a fine product and I had no technical problems or corruptions, or anything like that. My biggest issue with Diskeeper is graphical. The latest UI design left me a bit confused and I longed for the older interface because I knew where everything was. Also, Diskeeper long ago removed the disk mapping graphics, which show the clusters on a given partition as individual cells, and in even older versions, you could "walk the map" and see the layout of individual files and how they might contribute to fragmentation. Mostly, that display wasn't necessary, and I'll acknowledge that. But I liked it because it allowed me to get my geek fix, and then Diskeeper removed it.
The overhanging question in all this is of course, "do we still need to defrag?" It's a valid question, especially in today's increasingly ubiquitous SSD climate, where defragging is neither needed nor a good practice. Personally, I am on the cusp at this time due to the sheer amount of data that I have. But a good decision could be made by going either way, and in the future, maybe I won't need a defragger either! However, I do still maintain several spinning hard drive partitions (currently only on one physical HDD), and some of them still get updated on a semi-frequent basis. Eventually I just used my good judgement and gut feeling to decide that "this time", I'd like to still use a defragger for this machine.
So I got the Diskeeper (15?) Trial about a month ago and started using it. I was actually not very excited by it; it has been so oversimplified in the last several versions, and this latest one was like a toy version of the product. My personal corruption as an end-user really began with a few idle Google searches, and I saw Raxco's Perfect Disk. So when my Diskeeper trial ended, I didn't do what I always used to do which was buy an upgrade license without really thinking about it. This time, I remembered Raxco and I decided to check it out. I de-installed the Diskeeper trial and I've been using Perfect Disk for about a week now.
Here's what I like:
1. PD doesn't force me into the generic end-user category by hiding the scheduling options and making up for it by saying "oh our product is so resource friendly you can just set and forget". PD actually allows me to set a schedule. Thank you for letting me fit this product in with my usage patterns and my backup strategy!
2. PD also has a walk-map. Yay! I probably won't use it very often but I like having it there, dammit!
3. PD has the other stuff that Diskeeper has. A facility to allow files to be written/re-written without being fragmented. An easy way to just analyze drives. A clear way to see the status of my drives (including SMART information), and an easy way to take one out of my defrag strategy, such as the recovery partition on my SSD or the 3 TB drive I use for my Macrium Reflect backups.
4. The documentation is well laid out, and Raxco actually provides a bit more detail regarding their defragging methodologies. This impressed me.
There are other features that I don't use, such as a duplicate file-finder and a recycle bin management tool, but it's easy to just leave those turned off, and it's nice to know they're there.
I haven't yet found anything I don't like, but then I've only just begun the trial. Only today did I finally figure out how to set the scheduler correctly (Duh!), so it will be a few weeks yet before I make a decision. But so far so good.
Disclaimer: I am not and never have been affiliated with either Raxco or Condusiv or their products. I'm just a mildly dissatisfied partially geeky end-user who gets annoyed when new software is either dumbed down or when useful features are mysteriously removed.


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Related Items
Trending Stories
Bruce Arena Elected To National Soccer Hall Of Fame Class Of 2010
Former U.S. Men's National Team Head Coach Named to Hall on Builder Ballot;
Arena Named on 78 Percent of the Ballots to Earn Election to Hall
Former U.S. Men's National Team Head Coach Named to Hall on Builder Ballot;
Arena Named on 78 Percent of the Ballots to Earn Election to Hall
Carson, Calif. (Jan. 23, 2010) – Bruce Arena, whose coaching record includes two FIFA World Cups with the U.S., two MLS Cup titles and five NCAA Championships, has been elected to the National Soccer Hall of Fame Class of 2010 on the Builder ballot.
Arena was named on 78 percent of the ballots. In 2009, Arena was the leading vote-getter on the Builder ballot, but did not meet the requirement of being named to 50 percent of the ballots to earn election.
"Bruce Arena's passion for the game, ability to build exceptionally competitive teams at the collegiate and the professional level, and his outstanding work with the U.S. Men's National Team are well known and highly regarded by his colleagues and opponents," HOF President Jonathan Ullman stated. "His tremendous record of service in soccer and success in the game has earned him election to the Hall of Fame."
One of the most successful coaches in the history of soccer in the United States, Arena has already left his mark on the collegiate, professional and national team levels. In 18 seasons at the University of Virginia (seven of which he was also an assistant men's lacrosse coach), Arena won five national championships, including a dynastic four in a row from 1991-1994 on his way to an overall 295-51-31 record that effectively built the Cavaliers' program.
Arena left Virginia to take the head coaching position at newly-created D.C. United in the inaugural MLS season in 1996. Along with the MLS Cup, the 1996 Lamar Hunt U.S. Open Cup title earned D.C. the "Double" for the year, cementing the club in U.S. Soccer history. D.C. United went on to repeat its MLS Cup win in 1997, earning Arena MLS Coach of the Year honors.
Named as head coach of the U.S. Men's National Team after a disappointing 1998 FIFA World Cup, Arena built one of the most successful stretches in U.S. Soccer history. The height of his success on the national level was leading the team to their best-ever finish at the FIFA World Cup, reaching the quarterfinals in 2002 before losing a controversial game to world-power Germany. During his eight years as head coach, Arena compiled a record of 71-30-29, earning a .658 winning percentage.
After his time with the national team, Arena moved back into MLS, coaching the New York Red Bulls for a year and a half before being named general manager and head coach of the LA Galaxy in August of 2008. A year later, Arena led the Galaxy to the 2009 MLS Cup, falling to Real Salt Lake in a shootout.
To be eligible for the Hall of Fame as a Builder, an individual in a non-playing capacity must have demonstrated a major, sustained and positive impact on U.S. soccer on a national or first division professional level for a minimum of 10 years.
The selection committee for the Builder election consists of select soccer administrators and all Hall of Famers. The committee members vote for up to five Builders from the list of eligible candidates an annual 10-person ballot determined by a screening committee. One Builder can be elected each year and must have appeared on at least 50 percent of the ballots
Arena joins Thomas Dooley and Preki Radosavljevic, the Player electees to the Class of 2010. Results of the Veteran Player ballot will be released at a future date. The 2010 induction ceremony will likely be scheduled for this summer. Details are still being finalized and will be announced at a later date.
2010 Builder Ballot Elections Results
|Bruce Arena
|Bob Gansler
|Tony DiCicco
|Chuck Blazer
|46.30 %
|Francisco Marcos
|Dr. Robert S. Contiguglia
|Don Garber
|Sigi Schmid
|Kevin Payne
|Fritz Marth
Head Coach/Manager/General Manager
University of Virginia (1978-1995)
D.C. United (1996-1998)
U.S. Men's National Team (1998-2006)
New York Red Bulls (2007-2008)
Los Angeles Galaxy (2009-current)
During a more than 30-year career as a player, coach and manager, Bruce Arena has served as one of the bedrocks of the advancement of soccer in the United States. His record of success at the collegiate, professional, and international level is unsurpassed amongst U.S. coaches, collecting numerous honors including becoming one of only two coaches to win MLS Coach of the Year honors twice.
Responsible for the meteoric rise of the U.S. Men's National Team after he took the reigns in 1998, Bruce Arena's tenure at the helm of the U.S. team is regarded as the most successful in U.S. Soccer history. Under his leadership, the U.S. advanced to the quarterfinals of the FIFA World Cup for the first time in 72 years, collecting victories against Portugal and in the Round of 16 against Mexico in the 2002 tournament in Korea/Japan. Also during his tenure, the U.S. reached its highest-ever world ranking when they were listed fourth by FIFA in April of 2006. He led the U.S. to two CONCACAF Gold Cup titles in 2002 and 2005, as well as first place in CONCACAF World Cup qualifying for the 2006 FIFA World Cup. That campaign included one of the best home records in qualifying history, as the U.S. went undefeated in five home games during the final round of qualifying without surrendering a single goal. During his eight years as head coach, Arena compiled a record of 71-30-29, earning a .658 winning percentage to become the all-time leader in wins amongst coaches in U.S. National Team history.
Domestically, Arena earned the chance to lead the U.S. with a legendary coaching career that began at the University of Virginia. In 18 seasons in Charlottesville, Arena won five national championships, including a dynastic four in a row from 1991-1994 on his way to an overall record of 295-51-31.
Arena left Virginia to take the head coaching position at newly created D.C. United in the inaugural MLS season in 1996. Charged with creating a team from scratch, Arena put together a championship caliber team in their first year while also coaching the U.S. Under-23 National Team through the 1996 Olympic Games. Along with the MLS Cup, the 1996 Lamar Hunt U.S. Open Cup title earned D.C. the "Double", cementing the club in U.S. Soccer history. D.C. United went on to repeat as MLS Cup winners in 1997, earning Arena MLS Coach of the Year honors. A third straight appearance in the 1998 MLS Cup defied all expectations in a league predicated on parity, but D.C. United went one step further by becoming the first U.S. club to shine in international competitions, collecting the 1998 CONCACAF Champions Cup and then defeating famed Brazilian team Vasco da Gama to capture the 1998 Interamerican Cup.
After returning to MLS as the Head Coach and Sporting Director of the New York Red Bulls, he was hired in August of 2008 to resurrect the Los Angeles Galaxy. Taking over at a club that had failed to reach the playoffs for three consecutive seasons, Arena guided the team in 2009 to a 12-6-12 record and a first place finish in the Western Conference.
Bruce Arena Coaching Record
U.S. Men's National Team
Year GC W L T Pct.
1998 1 0 0 1 .500
1999 13 7 4 2 .615
2000 17 9 2 6 .706
2001 15 6 6 3 .500
2002 20 12 6 2 .650
2003 16 10 4 2 .688
2004 15 8 1 6 .733
2005 20 13 3 4 .750
2006 13 6 4 3 .577
9-Year Totals 130 71 30 29 .658
MLS Record
Year Club GC W L T Pct.
1996 D.C. United*$ 38 21 17 0 .579
1997 D.C. United*@ 37 26 11 0 .703
1998 D.C. United 38 28 10 0 .737
2006 New York Red Bulls 12+ 4 6 4 .500
2007 New York Red Bulls 32 12 12 8 .500
2008 Los Angeles Galaxy 10^ 2 5 3 .350
2009 Los Angeles Galaxy 34 14 7 13 .603-MLS Coach of the Year
7-Year Totals 201 107 68 28 .602
*MLS Cup Champions
$ U.S. Open Cup Champions
@MLS Supporters' Shield for best regular season record
^Arena was hired on Aug. 18, 2008
+Arena hired in mid-August
University of Virginia
Year GC W L T Pct.
1978 13 9 2 2 .769
1979 17 12 4 1 .735
1980 18 8 9 1 .472
1981 18 10 6 2 .611
1982 20 16 2 2 .850
1983 21 16 5 0 .762
1984 23 19 3 1 .848
1985 20 15 4 1 .775
1986 21 17 2 2 .857
1987 22 17 3 2 .818
1988 22 18 1 3 .886
1989 25 21 2 2 .880
1990 24 12 6 6 .625
1991 22 19 1 2 .909
1992 24 21 2 1 .896
1993 25 22 3 0 .880
1994 26 22 3 1 .865
1995 24 21 1 2 .916
18-Year Totals 385 295 59 31 .806

subset: commoncrawl


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Given Komen's long association with Planned Parenthood, the move has stunned pro-lifers everywhere and infuriated some Catholic organizations. The obvious rub comes from Planned Parenthood's highly profitable abortion business, and pro-lifers say that the Here's Hope Bible could channel funds from the sale of Holy Scripture to fund abortion.
Wal-Mart, the chosen re-seller, provides the publisher's description on its website:
The Here's Hope Breast Cancer Bible is a reminder that God has not forgotten you, a friend, or loved one who has been impacted by breast cancer. Not only will you find encouragement and inspiration through testimonies from breast cancer survivors but more importantly you'll encounter God's life-sustaining words for you.
But pro-lifers have not failed to connect the dots between the sale of this Bible and the possible funding of abortion.
The website Catholicsistas.com carried this strong comment:
... [M]uch of Komen's rhetoric is aimed at "awareness". Aren't we all "aware" of breast cancer by now? You can ask almost anyone, male or female, and they will likely be able to recite, by rote, the ways to prevent breast cancer: regular mammograms, healthy eating, avoidance of the Pill, and of course not having abortions. We know about self exams and exercising and even genetic testing. So this "awareness" is not as urgent as it once was.
Komen seems simply to have found a titillating way to stir up sentiment — and reap the cash rewards — and now they have stooped to the shameless exploitation of scripture! How dare an organization with a loathsome alliance with abortion giant, PP [Planned Parenthood], associate themselves with "scripture for profit"? Especially since a part of their share of the purchase price will, most likely, find its way to a cause of breast cancer — abortion! After all, $1 of every purchase of the Here's Hope Bible goes to Komen. Additionally disgraceful is that Komen's support of PP does nothing to prevent breast cancer — PP does not provide even one mammogram in any of its facilities, nationwide!
This year Planned Parenthood has received nearly $700,000 from Komen affiliates. So critics found the partnership with Lifeway Resources, based in Nashville, Tennessee, especially offensive. Lifeway is a non-profit organization under the aegis of the Southern Baptist Convention (SBC) and counts B&H Publishing as one of its divisions. In her Found4Life blog, Susan Tyrell writes that the Southern Baptist Convention is generally a strong supporter of the right to life, and wonders whether "the acquisition of this project was a matter of ignorance of the connection rather than ill-intent." She continues:
I'm left with only two responses. First, obviously, we can't support this Bible. Second, my response is to ask Lifeway and its affiliate company B&H to do whatever they need to stop this project. Is that a lofty thing to suggest? Sure. As a writer I'm aware of the issues with contracts, publication, legal matters. Will it be easy? Of course not. Will it cost? Yes, probably a lot. Is it the right thing to do to pull out of funding death? That should be a question we don't need to ask.
And the State Deputy of the Michigan Jurisdiction of the Knights of Columbus (a Catholic fraternal service organization) has ruled that no Knights of Columbus councils in Michigan may raise money or affiliate themselves with Komen.
Found4Life blogger Tyrell added, "The bottom line here is that all Bibles are a reminder God has not forgotten you. God loves breast cancer survivors and He loves the unborn. He loves them all, and it's not likely He's encouraging anyone to fund death to support breast cancer. All Bibles hold God's life-sustaining words, but the Here's Hope Breast Cancer Bible sucks hope from the womb and helps fund the robbery of hope from the unborn."
Those concerned with right-to-life issues are warned by one pundit to "think before you pink."


text:
Showing {{searchResults.length}} results. Please try again with other keywords.
Showing {{searchResults.length}} results. More results may be available, please refine your search.
(59) Customer Reviews
Price Range: USD $66.99 to $247.99
Passenger Cars
All Season
Ultra High Performance
The RS3-A™ is the latest Ultra High Performance all-season tire within the Cooper performance family. This all-season performance tire provides the driver with a dynamic handling and inspires confidence and control.
Advanced Technology Mold Profile. Provides for a square tread footprint which means more tread-to-road contact. Asymmetric Design. Allows for tread pattern tuning. This design allows for cross-rotation which reduces heal-toe wear, promotes even wear, less noise and increased overall read life. More rubber on the outboard tread pattern equals exceptional dry handling and traction. The large outside shoulder and intermediate tread elements increase handling, stability control and ultimate cornering ability. The offset shoulder-to-intermediate grooves and large intermediate tread elements are joined together for stable cornering and noise reduction. Laterally oriented shoulder grooves, uniform element geometry and chamfered edges resist irregular or rapid tread wear. The continuous, solid rib on the outside of the center row of tread elements increases steering response. The inboard tread pattern is optimized for wet and light snow conditions. Two, wide circumferential grooves channel water away from the tire for hydroplane resistance. Even wear is achieved by the laterally oriented shoulder grooves and uniform elements. Winter traction performance is aided by the technical sweeping elliptical groove. 3-D Micro-Gauge Siping. Increases tread element stability, improves handling and tire control while reducing the possibility of stone retention. 3-D dimple sipes with interlocking geometry provide more sipe depth without sacrificing tread element stability. The 3-D dimple sipes are used in the center, intermediate and shoulder elements and provide increased length and more road biting edges as the pattern wears for maximum wet and light snow traction. Silica Formulated Tread Compound. Designed for exceptional all-season driving performance.
You'll receive an alert as soon as this item is available for order.
I never used them in snow, so cannot rate, but it would not let me submit unless I do. I was basically happy with them, except that they wore out way too fast, getting less than half the rated mileage. As they wore they also developed a tendency to squeal, even going around a roundabout generated ridiculous squealing. Would not buy again.
Size: 215/50R17
Vehicle: 2015 Kia Rondo 4 Dr Hatchback LX with 27000 KM of Tire Wear
made this review on 8/30/2017 and is a
Confident, Experienced Driver
I paid almost $800 for a set of four tires. I had checked up on the reviews of these tires before purchasing them. I had read many great reviews and I was in need of a good set of all terrain tires. Mainly something that would hold up for a snowy winter but hot summer. well i bought the tires in november, by march with less than 18 thousand miles on them, the tires have been worn down beyond belief they need to be replaced ASAP. I had to special order these tires at Americas Tire. Their tech was also surprised with how fast the tires tread life wore and said they would give me a $200 credit. I am extremely disappointed, we are starting summer and have long vacation road trips ahead of us and we are set back a few hundred dollars because we need to purchase a new set of tires.
Size: 245/45R18
Vehicle: 2007 Nissan Maxima 4 Dr Sedan SE 18" option with 28962 KM of Tire Wear
made this review on 5/20/2017 and is a
Confident, Experienced Driver
Very secure feeling in corners. Aquaplaning resistance is excellent. Stable overall. Noise is dependent on surface texture more than Toyo and Generals I had before.
Size: 205/50R17
Vehicle: 2008 Mazda 5 4 Dr Mini Passenger Van Sport with 1609 KM of Tire Wear
made this review on 5/15/2017 and is a
Confident, Experienced Driver
Good tire but my winter tire are quieter. Beside the noise they make, I like how they handle on the road. 20000 km and still about 3/4 of thread left.
Vehicle: 2014 Ford Focus 4 Dr Sedan SE 17" option with 20000 KM of Tire Wear
made this review on 4/10/2017 and is a
Confident, Experienced Driver
To see all 59 reviews on tire reviews page
Treadlife Warranty
Cooper Zeon RS3-A 40,000 miles/20,000 miles**. **Staggered fitments can be defined as different tire sizes on the front and rear axles. Due to the inability to rotate onto different axles, the 20,000/10,000-mile (32,000/16,000 km) warranty applies to the rear tires only.
Uniformity Warranty
First 2/32" of wear (1)
Workmanship Materials Warranty
See Manufacturer Warranty Brochure
Manufacturers Road Hazard Warranty
Manufacturer Warranty Brochure
Download Brochure (PDF)
Manufacturer Special Warranty
Special Notes:
Warranty information provided may be innacurate, or may be out of date. Please see official manufacturer's warranty brochure for specific details.
New vehicle Original Equipment tire warranties often differ from those covering replacement tires. Consult your vehicle documents to confirm Original Equipment tire warranty coverage.
All orders are verified for fitment guarantee
Verified by tire & wheel expert
We honor the fitment.
If your vehicle information is present on your order, we will verify fitment to qualify you for the 100% Fitment Guarantee. If your order arrives and the tires or wheels do not fit your vehicle, we will honor an exchange and pay for freight for the return and new set.If there are concerns about your order we will contact you about potential fitment issues.
Our Fitment Guarantee applies to orders that come with full vehicle information (Year, Make Model, Sub-Model). If you are confident that the vehicle information is not necessary for your order, we will proceed without checking fitment. However, in the event there is a fitment issue with your order, we will honor a return/exchange, as per our
return / refund policy.
You will be responsible for freight charges (both ways).


text:
Well the logical answer is no.
But the logical answer to the question
"is it realistic for the lakers to choose Mike D'Antoni over 11 time champion Phil Jackson who is ready to come back and coach?"
is also no. Yet that happened. Maybe we should test the Lakers sanity with a trade offer


text:
OrbitClock is a dramatic countdown visualizer that will help you celebrate any special moment in time, such as the beginning of a new year, a birthday, or an anniversary. Display this fascinating ballet of planetary physics on a big screen to add an unforgettable twist to your special countdown party.
A GUI client for Git, Mercurial, and SVN.
A C/C++ configuration file manipulation library.


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Bullpen falters, Astros remain winless vs. A's
HOUSTON -- Perhaps the Astros are getting to the point they need to break out a voodoo doll or the Ouija board when the face the A's. Nothing else seems to be working, even on a night when Oakland tried to give the game away early.
The A's continued their dominance over the Astros, capping a three-run comeback with a two-run homer by Josh Reddick off lefty Wesley Wright in the eighth inning on Monday night at Minute Maid Park to send Oakland to its 12th consecutive win over the Astros, 4-3.Full Game Coverage
HOUSTON -- Perhaps the Astros are getting to the point they need to break out a voodoo doll or the Ouija board when the face the A's. Nothing else seems to be working, even on a night when Oakland tried to give the game away early.
The A's continued their dominance over the Astros, capping a three-run comeback with a two-run homer by Josh Reddick off lefty Wesley Wright in the eighth inning on Monday night at Minute Maid Park to send Oakland to its 12th consecutive win over the Astros, 4-3.Full Game Coverage
The A's improved to 10-0 this season against their new division rivals, outscoring them 72-34. They lead the all-time series against Houston, 15-1.
"Whenever you go 10-0 against a team, you're definitely playing well," Wright said. "But they definitely had a few breaks go their way as well. It's hard to lose 10 games in a row to a team. I feel like we're close, but we're just not over the hump just yet. Myself, personally, and the rest of us have to figure out a way to do it."
Wright (0-4) suffered the loss after serving up the game-winning homer on a 3-2 pitch with one out in the eighth. It was a lefty vs. lefty matchup that manager Bo Porter felt played into the Astros' hands.
"That is the right matchup," he said. "It's the matchup we want. If you don't win that matchup, you don't deserve to win the game."
Wright, who's been with the Astros longer than any other current player (six seasons), said he prides himself in coming into tight situations late in games and being able to get the job done -- especially since starter Dallas Keuchel left with a 3-1 lead after six innings.
"I like the pitch we had called," Wright said. "The execution could have been better, and it's one of those things we've been right there on the cusp all season. For myself, I've let a couple of games get away in situations I feel like I should have gotten the job done. I feel awful for Dallas and those guys."
Reddick's blast helped the A's match their best record after 99 games (58-41) in the past 23 years, and improved their record to 20-11 in one-run games. Grant Balfour worked a 1-2-3 ninth for his 44th straight save (26 this season).
"I was trying to sit slider," Reddick said of the home run at-bat. "The last time I faced him, he threw me a lot [of sliders], so I was waiting for one of those. He tried to nibble away with his fastball, over and over, and after a 3-1 check swing, I got a little frustrated with myself and had to step out of the box and talk myself down a little bit. He threw one right down the middle, and fortunately I didn't miss it."
It was a rough start for Oakland, which committed three errors in the first three innings that helped the Astros take a 3-0 lead. A's pitching righted the ship, holding the Astros hitless over the last five innings. The only runner to reach for Houston in that span came on Jose Altuve's leadoff walk in the eighth. He stole second before being thrown out trying to take third.
"This is definitely a ballgame we feel like we should have won," Porter said. "We put ourselves in position to win early, getting the lead, and I felt late in the game we did not execute the right pitches we needed to make to close it out."
Oakland's shoddy defense benefited the Astros, who took a 1-0 lead in the second when Justin Maxwell doubled, stole third and scored when shortstop Jed Lowrie bounced a throw to first that Nate Freiman couldn't scoop out of the dirt.
Astros shortstop Jonathan Villar, batting leadoff in his Major League debut, put a bunt single down to start the third and promptly stole second. Chris Carter drove him home with a two-out single to make it 2-0.
The A's should have escaped the inning when they got Maxwell to hit a shallow pop to right-center field, but it fell between three players -- second baseman Grant Green was charged with an error -- and a hustling Carter scored all the way from first to make it 3-0.
Keuchel carried a shutout into the sixth before giving up a run after the A's loaded the bases with one out. Chris Young homered off Travis Blackley in the seventh to get the A's to within a run, 3-2.
"It always feel good leaving the game with the lead," Keuchel said. "Obviously, I like to do my job, first of all. It was a struggle early. In the bullpen [before the game] I didn't feel real good, so I told [pitching coach Doug] Brocail, 'Hey, you might have to get someone up pretty early.' I fought hard and I got lucky there for a few innings. That's a good team, and they're a good team for a reason. I felt lucky to escape with one run."
Brian McTaggart is a reporter for MLB.com and writes an MLBlog, Tag's Lines. Follow @brianmctaggart on Twitter.


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Avg.Rate: 4750,00 ZAR - 14364,00
Rating: 4 stars
Shepherds Tree Game Reserve is a lodge concession, located on the south western portion of the Pilanesberg Game Reserve and 18 km away from Sun City. The elegantly furnished rooms offer views of the reserve and come with en-suite bathroom, minibar, TV and tea-and-coffee making facilities. Guided game drives in open game viewing vehicles are offered in the morning and evening. The area is malaria-free. Shepherds Tree Game Reserve also includes a spa centre and outdoor pool. Guests can enjoy the on-site restaurant. The lodge is a 2.5-hour drive from Johannesburg. mas


text:
Participating Organization(s)
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
Funding Opportunity Title
Functional Restoration of Salivary Glands (R01)
Activity Code
R01 Research Project Grant
Announcement Type
Related Notices
Funding Opportunity Announcement (FOA) Number
Companion FOA
RFA-DE-12-005, R21 Exploratory/Developmental Grant
Catalog of Federal Domestics Assistance (CFDA) Number(s)
FOA Purpose
This Funding Opportunity Announcement (FOA) encourages research that will utilize a variety of approaches for restoring damaged salivary gland function, including repair and regeneration of host salivary gland, and replacement with a bioengineered gland.
Posted Date
August 1, 2011
Open Date (Earliest Submission Date)
October 29, 2011
Letter of Intent Due Date
October 29, 2011
Application Due Date(s)
November 29, 2011 , by 5:00 PM local time of applicant organization.
AIDS Application Due Date(s)
Not Applicable.
Scientific Merit Review
February-March 2012
Advisory Council Review
May 2012
Earliest Start Date(s)
July 2012
Expiration Date
November 30, 2011
Due Dates for E.O. 12372
Not Applicable
Required Application Instructions
It is critical that applicants follow the instructions in the SF 424 (R&R) Application Guide except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.
Part 1. Overview Information
Part 2. Full Text of the Announcement
Section I. Funding Opportunity Description
Section II. Award Information
Section III. Eligibility Information
Section IV. Application and Submission Information
Section V. Application Review Information
Section VI. Award Administration Information
Section VII. Agency Contacts
Section VIII. Other Information
The goal of this initiative is to stimulate multidisciplinary research in the development of models and tools for repairing and restoring damaged salivary gland function. This FOA seeks a variety of approaches for restoration of salivary gland function, including repair and regeneration of the host salivary gland, and replacement of a diseased or damaged gland with a bioengineered gland.
Salivary gland hypofunction significantly compromises the quality of life of millions of Americans through associated poor oral health. Saliva is essential for maintaining oral homeostasis and serves multiple functions including lubrication, digestion, protection of oral and dental tissues, and host defense. Salivary gland disorders, which result in xerostomia and reductions in salivary flow, increase the risk of dental caries, mucosal infections, dysgeusia (taste disorder), and difficulties in swallowing and speaking. The most common disorder involving the salivary glands is Sjögren's syndrome, an autoimmune disease affecting up to 4 million Americans, mostly middle-aged women. Although salivary gland tumors are rare, with approximately 3,300 new cases per year, surgical and radiation interventions can destroy the glands. Furthermore, radiation therapy to other head and neck cancers significantly damages the salivary glands in an estimated 40,000 individuals annually. Therefore, salivary gland hypofunction has diverse root causes, and restoration of function must address the underlying mechanisms of tissue damage.
Treatment options are limited and artificial saliva or saliva-stimulating agents provide only short-term relief management. Despite a wealth of knowledge in basic salivary gland biology, few breakthroughs have occurred which can be clinically applied toward restoration of compromised salivary gland function. Progress has been made in identifying and characterizing molecular, cellular, and cell-matrix interaction cues for salivary gland differentiation; putative salivary gland stem and progenitor cells; and bioactive scaffolds that may contribute to the design of an artificial salivary gland. While some studies have investigated the structural integrity of repaired or regenerated salivary glands, or tissue-specific gene expression, no studies have demonstrated an outcome of intact secretory physiology, such as rate, extent and direction of fluid movement, fluid composition, integrity of tight junction complexes, or transepithelial resistance. On the other hand, state-of-the-science technologies and approaches are utilized in the design and regeneration of other organ systems, which could be brought to bear on salivary gland repair. New multidisciplinary approaches with inclusion of investigators experienced in various aspects of soft/glandular tissue repair are needed to propel salivary research towards meeting clinical needs in tangible and meaningful ways.
Targeted research in response to this FOA should capitalize on cell-, protein/peptide-, small molecule-, gene-, and material-based approaches coupled with bioengineering to advance studies on stimulating salivary gland fluid secretion. As an example, studies could concentrate on increasing the activities of channels and transport proteins, or repairing and/or replacing defective acinar and ductal cells within secretory units. Current research is also hampered by the lack of relevant animal models, dynamic tools and reproducible methods to reliably examine salivary function. Therefore, this initiative also encourages the development of such models (e.g. in vivo animal models, ex vivo multiple tissue constructs and/or in vitro systems). Partnering of salivary researchers or secretory biologists, with investigators from other disciplines such as chemists, physiologists, structural biologists, radiation biologists, stem cell biologists, bioengineers, material scientists and clinical investigators through the use of a multiple-PI project format is strongly encouraged. Salivary gland performance must be assessed with functional assays and endpoints.
Research projects could include, but are not limited to, the following:
This FOA will not consider:
Funding Instrument
Application Types Allowed
The OER Glossary and the SF 424 (R&R) Application Guide provide details on these application types.
Funds Available and Anticipated Number of Awards
NIDCR intends to support five to six R01 applications solicited through this FOA. A companion FOA, RFA-DE-12-005, will support an additional three to four R21 exploratory/developmental grant applications. NIDCR intends to commit up to $3 million in FY2012 to support meritorious projects solicited through these two FOAs.
The number of awards is contingent upon NIH appropriations, and the submission of a sufficient number of meritorious applications.
Award Budget
Because the nature and scope of the proposed research will vary among applications, it is anticipated that the size and duration of each award will also vary. Although R01 applications are not limited, the amount should be appropriate for the proposed work.
Award Project Period
The total project period for an application submitted in response to this funding opportunity may not exceed four years.
NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.
Higher Education Institutions:
The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
Nonprofits Other Than Institutions of Higher Education
For profit Organizations
Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.
Foreign (non-U.S.) components of U.S. Organizations are allowed.
Applicant organizations must complete the following registrations
as described in the SF 424 (R&R) Application Guide to be eligible to apply
for or receive an award. Applicants must have a valid Dun and Bradstreet
Universal Numbering System (DUNS) number in order to begin each of the following
All Program Directors/Principal Investigators (PD/PIs) must
also work with their institutional officials to register with the eRA Commons
or ensure their existing eRA Commons account is affiliated with the eRA Commons
account of the applicant organization.
All registrations must be completed by the application due date. Applicant organizations are strongly encouraged to start the registration process at least four (4) weeks prior to the application due date.
Any individual(s) with the skills, knowledge, and resources
necessary to carry out the proposed research as the Project Director/Principal
Investigator (PD/PI) is invited to work with his/her organization to develop an
application for support. Individuals from underrepresented racial and ethnic
groups as well as individuals with disabilities are always encouraged to apply
for NIH support.
For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF 424 (R&R) Application Guide.
Because of the multidisciplinary nature of the projects, partnering of salivary researchers or secretory biologists with chemists, structural biologists, radiation biologists, stem cell biologists, bioengineers, material scientists, or clinical investigators through the use of Multiple Program Director/Principal Investigator project format is strongly encouraged. For details on submitting an application in this format, please see https://grants.nih.gov/grants/multi_pi/index.htm
This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.
Applicant organizations may submit more than one application, provided that each application is scientifically distinct.
NIH will not accept any application in response to this FOA that is essentially the same as one currently pending initial peer review unless the applicant withdraws the pending application. NIH will not accept any application that is essentially the same as one already reviewed.
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the "Apply for Grant Electronically" button in this FOA or following the directions provided at Grants.gov.
It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.
By the date listed in Part 1. Overview Information, prospective applicants are asked to submit a letter of intent that includes the following information:
Descriptive title of proposed research
Name, address, and telephone number of the PD(s)/PI(s)
Names of other key personnel
Participating institutions
Number and title of this funding opportunity
The letter of intent should be sent to:
Lynn Mertens King, PhD
Chief, Scientific Review Branch
6701 Democracy Blvd., Rm. 662
Bethesda, MD 20892-4878 (20817 for express deliveries)
Phone: 301-594-5006
The forms package associated with this FOA includes all applicable components, mandatory and optional. Please note that some components marked optional in the application package are required for application submission. Follow all instructions in the SF424 (R&R) Application Guide to ensure you complete all appropriate "optional" components.
All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed,
All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:
Research Strategy
Under Approach, in the Research Strategy section of the Research plan, applications must address how salivary gland performance will be assessed with functional assays and endpoints.
Resource Sharing Plan
Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies (GWAS) as provided in the SF424 (R&R Application Guide).
Do not use the appendix to circumvent page limits. Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide.
Foreign (non-US) organizations must follow policies described in the NIH Grants Policy Statement, and procedures for foreign organizations described throughout the SF424 (R&R) Application Guide.
Applications with Multiple PDs/PIs
Because of the multidisciplinary nature of the projects, partnering of salivary researchers or secretory biologists with chemists, structural biologists, radiation biologists, stem cell biologists, bioengineers, material scientists, or clinical investigators through the use of Multiple Principal Investigators project format is strongly encouraged. For details on submitting an application in this format, please see https://grants.nih.gov/grants/multi_pi/index.htm
When multiple PDs/PIs are proposed, NIH requires one PD/PI to be designated as the "Contact" PD/PI, who will be responsible for all communication between the PDs/PIs and the NIH, for assembling the application materials outlined below, and for coordinating progress reports for the project. The contact PD/PI must meet all eligibility requirements for PD/PI status in the same way as other PDs/PIs, but has no other special roles or responsibilities within the project team beyond those mentioned above.
Information for the Contact PD/PI should be entered on the SF424 (R&R) Cover component. All other PDs/PIs should be listed in the Research & Related Senior/Key Person component and assigned the project role of "PD/PI." Please remember that all PDs/PIs must be registered in the eRA Commons prior to application submission. The Commons ID of each PD/PI must be included in the "Credential" field of the Research & Related Senior/Key Person component. Failure to include this data field will cause the application to be rejected.
Multiple PD/PI Leadership Plan: For applications designating multiple PDs/PIs, the Research Plan section, and Multiple PD/PI Leadership Plan, must be included. A rationale for choosing a multiple PD/PI approach should be described. The governance and organizational structure of the leadership team and the research project should be described, and should include communication plans, process for making decisions on scientific direction, and procedures for resolving conflicts. The roles and administrative, technical, and scientific responsibilities for the project or program should be delineated for the PDs/PIs and other collaborators.
If budget allocation is planned, the distribution of resources to specific components of the project or the individual PDs/PIs should be delineated in the Leadership Plan. In the event of an award, the requested allocations may be reflected in a footnote on the Notice of Award (NoA).
Applications Involving a Single Institution
When all PDs/PIs are within a single institution, follow the instructions contained in the SF424 (R&R) Application Guide.
Applications Involving Multiple Institutions
When multiple institutions are involved, one institution must be designated as the prime institution and funding for the other institution(s) must be requested via a subcontract to be administered by the prime institution. When submitting a detailed budget, the prime institution should submit its budget using the Research & Related Budget component. All other institutions should have their individual budgets attached separately to the Research & Related Subaward Budget Attachment(s) Form. See Section 4.8 of the SF424 (R&R) Application Guide for further instruction regarding the use of the subaward budget form.
When submitting a modular budget, the prime institution completes the PHS398 Modular Budget component only. Information concerning the consortium/subcontract budget is provided in the budget justification. Separate budgets for each consortium/subcontract grantee are not required when using the Modular budget format. See Section 5.4 of the Application Guide for further instruction regarding the use of the PHS398 Modular Budget component.
Part I. Overview Information contains information about Key Dates. Applicants are encouraged to submit in advance of the deadline to ensure they have time to make any application corrections that might be necessary for successful submission.
Organizations must submit applications via Grants.gov, the online portal to find and apply for grants across all Federal agencies. Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH's electronic system for grants administration.
Applicants are responsible for viewing their application in the eRA Commons to ensure accurate and successful submission.
Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide.
This initiative is not subject to intergovernmental review.
All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
Pre-award costs are allowable only as described in the NIH Grants Policy Statement.
Applications must be submitted electronically following the instructions described in the SF 424 (R&R) Application Guide. Paper applications will not be accepted.
Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.
For assistance with your electronic application or for more information on the electronic submission process, visit Applying Electronically.
All PD/PIs must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile Component of the SF 424(R&R) Application Package. Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH.
The applicant organization must ensure that the DUNS number it provides on the application is the same number used in the organization's profile in the eRA Commons and for the Central Contractor Registration (CCR). Additional information may be found in the SF424 (R&R) Application Guide.
See more tips for avoiding common errors.
Upon receipt, applications will be evaluated for completeness by the Center for Scientific Review and responsiveness by NIDCR, NIH. Applications that are incomplete and/or nonresponsive will not be reviewed.
In order to expedite review, applicants are requested to notify the NIDCR Referral Office by email at email@example.com when the application has been submitted. Please include the FOA number and title, PD/PI name, and title of the application.
Applicants are required to follow the instructions for post-submission materials, as described in NOT-OD-10-115
Only the review criteria described below will be considered in the review process. As part of the NIH mission, all applications submitted to the NIH in support of biomedical and behavioral research are evaluated for scientific and technical merit through the NIH peer review system.
Reviewers will provide an overall impact/priority score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).
Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.
Does the project address an important problem or a critical barrier to progress in the field? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?
Are the PD/PIs, collaborators, and other researchers well suited to the project? If Early Stage Investigators or New Investigators, or in the early stages of independent careers, do they have appropriate experience and training? If established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD/PI, do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project?
Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed?
Are the overall strategy, methodology, and analyses
well-reasoned and appropriate to accomplish the specific aims of the project?
Are potential problems, alternative strategies, and benchmarks for success
presented? If the project is in the early stages of development, will the
strategy establish feasibility and will particularly risky aspects be
If the project involves clinical research, are the plans for 1) protection of human subjects from research risks, and 2) inclusion of minorities and members of both sexes/genders, as well as the inclusion of children, justified in terms of the scientific goals and research strategy proposed?
Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?
As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact/priority score, but will not give separate scores for these items.
Protections for Human Subjects
For research that involves human subjects but does
not involve one of the six categories of research that are exempt under 45 CFR
Part 46, the committee will evaluate the justification for involvement of human
subjects and the proposed protections from research risk relating to their
participation according to the following five review criteria: 1) risk to
subjects, 2) adequacy of protection against risks, 3) potential benefits to the
subjects and others, 4) importance of the knowledge to be gained, and 5) data
and safety monitoring for clinical trials.
For research that involves human subjects and meets the criteria for one or more of the six categories of research that are exempt under 45 CFR Part 46, the committee will evaluate: 1) the justification for the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials. For additional information on review of the Human Subjects section, please refer to the Human Subjects Protection and Inclusion Guidelines.
Inclusion of Women, Minorities, and Children
When the proposed project involves clinical research, the committee will evaluate the proposed plans for inclusion of minorities and members of both genders, as well as the inclusion of children. For additional information on review of the Inclusion section, please refer to the Human Subjects Protection and Inclusion Guidelines.
Vertebrate Animals
The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following five points: 1) proposed use of the animals, and species, strains, ages, sex, and numbers to be used; 2) justifications for the use of animals and for the appropriateness of the species and numbers proposed; 3) adequacy of veterinary care; 4) procedures for limiting discomfort, distress, pain and injury to that which is unavoidable in the conduct of scientifically sound research including the use of analgesic, anesthetic, and tranquilizing drugs and/or comfortable restraining devices; and 5) methods of euthanasia and reason for selection if not consistent with the AVMA Guidelines on Euthanasia. For additional information on review of the Vertebrate Animals section, please refer to the Worksheet for Review of the Vertebrate Animal Section.
Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.
Not Applicable.
Not Applicable.
Not Applicable.
As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact/priority score.
Applications from Foreign Organizations
Reviewers will assess whether the project presents special opportunities for furthering research programs through the use of unusual talent, resources, populations, or environmental conditions that exist in other countries and either are not readily available in the United States or augment existing U.S. resources.
Select Agent Research
Reviewers will assess the information provided in this section of the application, including 1) the Select Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select Agent(s).
Resource Sharing Plans
Reviewers will comment on whether the following Resource Sharing Plans, or the rationale for not sharing the following types of resources, are reasonable: 1) Data Sharing Plan; 2) Sharing Model Organisms; and 3) Genome Wide Association Studies (GWAS).
Budget and Period of Support
Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.
Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s) convened by the National Institute of Dental and Craniofacial Research (assignments will be shown in the eRA Commons), in accordance with NIH peer review policy and procedures, using the stated review criteria.
As part of the scientific peer review, all applications:
Applications will compete for available funds with all other recommended applications submitted in response to this FOA . Following initial peer review, recommended applications will receive a second level of review by the National Advisory Dental and Craniofacial Research Council . The following will be considered in making funding decisions:
After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement (written critique) via the eRA Commons.
Information regarding the disposition of applications is available in the NIH Grants Policy Statement.
If the application is under consideration for funding, NIH
will request "just-in-time" information from the applicant as
described in the NIH Grants
Policy Statement.
A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the grantee business official.
Awardees must comply with any funding restrictions described in Section IV.5. Funding Restrictions. Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs.
Any application awarded in response to this FOA will be subject to the DUNS, CCR Registration, and Transparency Act requirements as noted on the Award Conditions and Information for NIH Grants website.
All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities. More information is provided at Award Conditions and Information for NIH Grants.
Cooperative Agreement Terms and Conditions of Award
Not Applicable.
When multiple years are involved, awardees will be required to submit the Non-Competing Continuation Grant Progress Report (PHS 2590) annually and financial statements as required in the NIH Grants Policy Statement.
A final progress report, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the NIH Grants Policy Statement.
The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later. All awardees of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at www.fsrs.gov on all subawards over $25,000. See the NIH Grants Policy Statement for additional information on this reporting requirement.
We encourage inquiries concerning this funding opportunity
and welcome the opportunity to answer questions from potential applicants.
Customer Support (Questions regarding Grants.gov registration and
submission, downloading or navigating forms)
Contact Center Phone: 800-518-4726
Email: email@example.com
GrantsInfo (Questions regarding application instructions and
process, finding NIH grant resources)
Telephone 301-710-0267
Email: firstname.lastname@example.com
eRA Commons Help Desk(Questions regarding eRA Commons
registration, tracking application status, post submission issues)
Phone: 301-402-7469 or 866-504-9552 (Toll Free)
Email: firstname.lastname@example.com
Penny Wung Burgoon, Ph.D.
Director, Salivary Biology and Immunology Program
National Institute of Dental and Craniofacial Research (NIDCR)
Telephone: 301-594-4825
Email: firstname.lastname@example.com
Lynn Mertens King, PhD
Chief, Scientific Review Branch
National Institute of Dental and Craniofacial Research (NIDCR)
Phone: 301-594-5006
Email: email@example.com
Mary Daley Greenwood
Chief, Grants Management Officer)
National Institute of Dental and Craniofacial Research (NIDCR)
Telephone: 301-594-4808
Email: email@example.com
Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 45 CFR Parts 74 and 92.
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NIH... Turning Discovery Into Health®
Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.


text:
The H1N1 virus (swine flu) was a new flu virus strain that caused a worldwide pandemic in humans from June 2009 to August 2010.
The Centers for Disease Control and Prevention now call the virus 2009 H1N1.
Swine flu
Earlier forms of the H1N1 virus were found in pigs. Over time, the virus changed (mutated) and infected humans. H1N1 was a new virus in humans in 2009, and it spread quickly around the world. Most of the people who got the H1N1 flu were ages 5 - 24.
During the 2010-2011 flu season, H1N1 virus (swine flu) did not cause widespread infections as it had in 2009-2010. The 2010-2011 seasonal flu vaccine also protected against swine flu, and a separate vaccine was not needed. The same is true for the 2011-2012 seasonal flu vaccine
Any flu virus can spread from person to person when:
You cannot get H1N1 flu virus from eating pork or any other food, drinking water, swimming in pools, or using hot tubs or saunas.
See also: Influenza vaccine.
Centers for Disease Control and Prevention (CDC). Prevention and Control of Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2011. MMWR. 2011 Aug 26;60:1128-32.
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CRIMES & INCIDENTSPolice searching for man accused of kicking in real estate agency's window
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AROUND TOWNI support the city government efforts in working towards a possible Costco being built in Pleasanton.
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SCHOOLS & KIDSIs PUSD drinking water full of lead in Pleasanton and poisoning the kids?
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BOOKS & MOVIESSpring concert by Pleasanton Community Concert Band set for today at Firehouse Arts Center
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CRIMES & INCIDENTSFamily of teen fatally shot by Pleasanton police sues department, requests jury trial
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COMMENTS ON STORIESCostco seen as potential buyer of Pleasanton development Zone site
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Halle Berry + Olivier Martinez Wed in France
She once swore she'd never do it again, but hey, things change: Twice-married Halle Berry took her third stroll down the aisle this weekend and swapped vows with her boyfriend (and baby daddy), actor Olivier Martinez.
French website Pure People reports the pair married on Saturday evening, July 13, at the Chateau des Conde in Vallery, France, after having their legally-required civil union earlier in the day. (In Europe, all couples are first legally wed with a civil union — religious ceremonies are optional and held afterwards.)
About 60 people — mainly close friends and family — attended. It was Berry's third marriage and Martinez's first.
The 46-year-old pregnant Oscar winner and the French-born actor, 47, met three years ago while co-starring in the little-seen movie 'Dark Tide.' Back in April, they announced they were expecting their first child together (last month we found out it's a boy). Berry already has a 5-year-old daughter, Nahla, with model — and occasional sparring partner — Gabriel Aubrey.
Our best wishes to the newlyweds.


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Read the full story here Web Link posted Thursday, January 12, 2012, 11:51 AM
Town Square
Hospital workers vote to keep union
Original post made on Jan 12, 2012
Read the full story here Web Link posted Thursday, January 12, 2012, 11:51 AM
Comments (8)
a resident of Sylvan Park
on Jan 12, 2012 at 2:29 pm
Why is union membership forced upon employees? If it's such a wonderful thing shouldn't we have the choice to subscribe, or not?
a resident of Old Mountain View
on Jan 12, 2012 at 2:31 pm
SEIU is simply a joke. They are less interested in representing their members and more interested in pursuing their political agenda.
Having said that if the workers are stupid enough to vote to keep paying their hard earned money to these clowns, then it's on their heads.
a resident of Old Mountain View
on Jan 12, 2012 at 2:37 pm
@Steve from Sylvan Park.
You would be talking about a right to work state. Something that I doubt the People's Republic of California will ever become.
a resident of Waverly Park
on Jan 12, 2012 at 4:23 pm
The few times I have had people at the hospital be rude or delivered bad service they ALWAYS proudly wear their SEIU buttons.
SEIU needs to keep collecting dues so they can continue to buy politicians and elections and true reform from ever coming to California.
a resident of The Crossings
on Jan 13, 2012 at 6:17 am
They reap what they sow. They cannot complain about paying dues now. They can't complain about working with someone who always breaks rules and then hides behind the union and never gets fired. They can't complain about anything. The hospital let the union in. The hospital let the reps run around the wards and badger employees and patients and patient families. The hospital let the reps get away with anything. The hospital might as well let the union officially run the hospital and save a few more dollars by getting rid of the administrators.
a resident of another community
on Jan 17, 2012 at 10:51 pm
I have worked at ECH for more than 30 years. The Union has been here for about 10 years. Before the union came here we went 2 years with no pay increases, some people took pay cuts, job descriptions were changed without consulting the workers, and new positions or shift changes were done without regard to seniority. The union brought us improved healthcare for ourselves and family. They improved our pay so that it is comparable to what other hospitals workers in the area get. We have representation at disciplinary hearings. I am a steward and have represented many employees at disciplinary hearings and I know that employees who make grievous or repeated mistakes do get fired. Seniority is respected when there are open positions. My dues are 2% of my base salary and worth every cent. If we allowed some members to not pay dues, we still are obligated to represent them. I love ECH, I am not a disgruntled employee, both my wife and myself have had surgeries and been hospitalized there, my son was born there. I am better off being represented by a healthcare union.
a resident of another community
on Jan 17, 2012 at 11:06 pm
I too am an El Camino Hospital employee. I gladly pay my dues simply because I get what I pay for. I was here before employees had a contract and I was here when employees were allowed to be a member or not be a member. Now when there is a disagreement between workers and a manager, the disagreement is resolved by looking it up in the contract. If my work is changed, I have a chance to talk about it and present my own ideas. When people could be a member or not they got the same benefit as me and didn't pay for it.
a resident of Cuesta Park
on Jan 30, 2012 at 11:41 am
I think that the point is simply this: Why are employees being forced to be a part of this Union? Shouldn't there be a choice? I thought this was America. Right or wrong, good or bad, difference of opinions...whatever the reasons employess should be given a choice to choose and decide for themselves. This is forceful payment of dues. No payment = no job. we all answer to SEIU now, not ECH.
Last point...someone do the math...where are all the Millions of dollars in dues going? Look it up.
Thank you for the article.
Burger chain Shake Shack to open in Palo Alto
By Elena Kadvany | 16 comments | 4,260 views
The Cost of Service
By Aldis Petriceks | 1 comment | 972 views
Couples: When Wrong Admit It; When Right; Shut Up
By Chandrama Anderson | 0 comments | 450 views


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Hot wheels! Matchbox cars raced down orange plastic track, Tonka Toys in the sandpit, Dinky Toys left strategically on the stairs or preserved forever in a pristine box. All kinds of toy cars, from die cast collectibles to plastic monster trucks and wooden helicopters can be found in this section.
Brand: Sun Star / Type: Buses
* Prices may differ from that shown


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>News and Announcements>Automated Cool Running log import
Indy Half Marathon
Please do not post your password in public forums.
Lou, (aka Mr. predawnrunner), MD, USA | Lou's Brews | firstname.lastname@example.com
I never kept my log at coolrunning, but I do have an excel log I wouldn't mind importing.
Can you give a list of fields? What are the headers?
Thanks so much for all the effort, I imported my log with no problem, took only a few seconds.
The only thing that didn't quite make it right was my courses. The names are there in the drop down menu, but the distances don't automatically come up. I have now figured out how to edit the routes though so I am just doing it manually...not that big of a deal.
Again, a million thanks for all the work...now promise you won't sell to those bums at active.


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Name: Sasori
Nickname: Sasori of the Red Sand
Gender: Male
Age: 35
Team: Puppet Brigade
Looks: Without puppet armour, Sasori maintained the appearance of a teenage boy with wide brown eyes which he inherited from his mother, and short, red hair which he inherited from his father. As a child, Sasori wore green robes with a pale jacket around them. As an adult, he was mostly seen in his Akatsuki robe. Sasori's puppet form consisted of a pair of spinning claws attached to his lower back, a holder for four scrolls on his back, a stinger in the empty and open stomach cavity, a compartment in his right chest, and a 'core of living flesh' in the left which had the kanji for "Scorpion" painted on it. In his exposed state, Sasori's eyes would also be wide open in a maniacal way, as opposed to his normal calm looking eyes.
Sasori wore his Akatsuki ring on his left thumb. The ring bears the kanji for jewel or sphere. He also wore teal nail polish. Even though Sasori possessed a headband from Sunagakure that was slashed out in the middle, he never physically wore it, but instead kept it on his person.
Personality: Sasori grew up in a sad and lonely environment due to the absence of parental love. When introduced to the art of puppetry by his grandmother, Chiyo, he grew a little happier. He eventually created puppets in the likeness of his parents, but when he realised that the puppets couldn't give him the actual love that he desired, he became cold and aloof. This led to his maintaining little regard for human life. Sasori even went so far as to state that he would feel nothing if Chiyo died, as he claimed that his heart had become like his puppet body: without any emotions. Despite his cruel nature, Sasori was also known to possess a very down-to-earth outlook on life, rarely getting worked up over obstacles that impeded his way. He rarely gave way to any strong emotions, and such instances that happened were often short-lived.
Sasori was also known for his impatience, as he repeatedly noted that he did not wish to wait or keep others waiting.
Village Info:
Village of Birth:
Village of Alliance: N/A
Rank & Chakra Info:
Ninja Rank: Genin
Elements : (Needs training)
Your Ninjutsu:
(Hitokugutsu) - Human Puppet
Chakra Cost:N/A
Damage Points:N/A
Description:The user creates a puppet out of a living person.The puppet can be the user and well retain all jutsu the original knew.
(Bikoku Ninjutsu) - Shadow Stealth Technique
Chakra Cost:5
Damage Points:N/A
Description:This jutsu lets the user follow the target covert by concealing the users presence.
(Henge no Jutsu) - Transformation Technique
Damage Points:N/A
Description: Henge no Jutsu is a Ninjutsu technique, which every ninja learns at the Ninja Academy. Henge allows the ninja to transform themselves into any person or object. This allows the ninja to move with stealth or to trick their opponents.
(Gokan Sakusou) - 5 Senses Confusion Disorder
Chakra Cost:N/A
Damage Points:N/A
The user throws an explosive kunai at their target and the mist spreads threw the air.This jutsu causes the opponent to be hit by attacks even though they think they dodged it or countered it.This effect lasts for 2 turns.
(Kawarimi no Jutsu) - Change of Body Stance Technique
Chakra Cost:5
Damage Points:N/A
Description: Kawarimi no Jutsu is a basic Ninjutsu technique. When in danger the ninja will quickly substitute themselves with another nearby object. This can be a block of wood or even another person. This allows the ninja to quickly flee and hide while the original object takes the brunt of their opponents attack.
(Nawanuke No Jutsu) - Escape Skill
Chakra Cost:5
Damage Points:N/A
Description:Using chakra the user can escape from being tied down(only works with non-chakra ropes).
History: When Sasori was young, his father and mother were killed by Sakumo Hatake in battle, leaving him in the care of his grandmother, Chiyo. When Chiyo attempted to cheer him up by teaching him puppetry at age five, Sasori's innate aptitude for the art became apparent, and he even began to devise masterful ways of eliminating a puppet master's weaknesses in battle. His skills even allowed him to create two puppets in the image of his parents in an attempt to discard the terrible loneliness he felt. However, as the puppets were unable to give him the real parental love that he desired, Sasori lost interest in them, and they later fell into Chiyo's possession. Sasori created many other ingenious puppets, including Black Ant, Crow (puppet), and Salamander, which were later owned by Kankuro. During the Third Shinobi World War, the effectiveness of his puppets in spilling enemies' blood on the sand gave rise to Sasori's moniker Sasori of the Red Sand. However, motivated by his desire to make works that last forever, Sasori began experimenting to create puppets out of people.
Twenty years before his introduction in the series, Sasori left Sunagakure at age fifteen after he secretly kidnapped the Third Kazekage and made him into one of his human puppets. Sasori also transfered his heart into a puppet body modelled after himself to increase his own offensive capabilities and prolong his life. Some time after leaving the village, Sasori joined the Akatsuki and utilised his skills to create numerous spies like Yūra and Mukade in many nations as sleeper agents. Prior to being partnered with Deidara, Sasori was paired with Orochimaru, who shared his desire of an everlasting existence. However, when Orochimaru left the Akatsuki after his failed attempt to take Itachi Uchiha's body, Sasori bore a grudge towards his former partner and sent Kabuto Yakushi to be his spy in Otogakure. Nevertheless, Sasori was unaware that Kabuto was working for Orochimaru long before he posed as an Akatsuki spy, with him and the rest of the Akatsuki made to think that Kabuto joined Orochimaru's side after being dispelled of Sasori's brainwashing. Sasori and his second partner in Akatsuki, Deidara, both had conflicting views on art, and they frequently argued about their differing perspectives. Deidara maintained his belief that art was something transient that departs quickly, where as Sasori believed that fine art was everlasting and remained far into the future. This reflected their individual natures; Deidara made clay sculptures which exploded, while Sasori created long-lasting puppets out of humans that never died. Nevertheless, although Deidara outwardly seemed to respect Sasori's beliefs, Sasori never respected Deidara's.
Sasori's ambition was to become an exquisite piece of art himself by turning his body into one of his own puppet works. Sasori adhered so strongly to his belief that true art was ever-lasting that he even went as far as to have his spy, retrieve information on the Summoning: Impure World Reincarnation and human experiments. Sasori abandoned this ambition after Kankurō told him that it was his creations that he put his heart and soul into that would last forever. After accepting Kankurō's view on eternal art, he entrusted his Mother and Father puppets to Kankurō and told him to pass them on to the next generation after he dies. In this moment, Sasori is shown to have an emotional side as well.
Sasori was also willing to accept the views of others on certain topics in contrast to Deidara, who stubbornly stood by his beliefs until the end. Sasori spared Kankurō during their first confrontation after the latter made a last attempt to attack him, but he notes that Kankurō's envenomed state would eventually lead to his death.
Other: Trained by his powerful grandmother, Chiyo, in the art of puppetry, Sasori was an extremely powerful puppeteer and had great skill in creating and controlling his puppets. He created a number of ingenious ones including the three main puppets that Kankurō uses, which were made in Sunagakure before he fled. At the time of the battle that led to his death, Sasori had 298 human puppets in his collection. His status as a puppet master offered him a tremendous advantage against other puppeteer shinobi, especially if the puppets they were using happened to be ones that he created, as seen in his battle against Kankurō. As puppets are usually installed with long-range weapons, Sasori was an expert at fighting at long distances. Sasori can also control living people as puppets, even against their will, if they are weakened enough. His usage of puppets was at such a high level that he made mere techniques appear as an artistic performance.
Sasori was also apart of the Puppet Brigade of Sunagakure along with his grandmother, Chiyo.
Legacy: At the time of his death, Sasori had not yet captured his assigned tailed beast. A short dialogue between himself and Deidara suggested that Sasori did not even know what beast he had been assigned to target. However, after his death, Tobi took his place as Deidara's new partner and his ring in Akatsuki, and, later, he captured the Three-Tails, thereby suggesting that the beast was Sasori's target.
However, due to the preservation of his body, Sasori's influence on future events was not over with his death. Prior to the events at the Five Kage Summit, Kankurō recovered Sasori's body to replace his usual puppets. It seems that some modifications have been made to his body since Sasori's death, although it is unknown if certain mechanisms were previously installed, but were not shown prior to Sasori's death. Using Scorpion to fight the reincarnated Sasori, Kankurō manages to give Sasori closure by stating he achieved his immortality through all the puppets he made.
Won: Well, a lot
Lost: Why would he lose?


text:
Select Board endorses train study
In a one-time departure from the normal routine, the meeting was held at the new Park House at Dana L. Thompson Memorial Park.
Along with the board reorganizing itself following town meeting, the topic of passenger rail service coming to Manchester made a return stop.
"The presentation that was different from ones we have had previously throughout the years," said the board's chairman, Ivan Beattie, after the meeting. "What's great is the train would stop and then travel through Manchester, instead of just stopping and turning around like other studies have shown in the past,"
Beattie said that the board showed overwhelming support for train service and that it could not only bring more people to the area from as far away as New York City, but it would also bolster the downtown area and make it more pedestrian friendly.
"One thing that this area has been missing compared to other towns in the State is some form of public transportation," he said. "We don't have buses here anymore. We don't have an interstate that runs through and train service is something that people tend to enjoy traveling on."
Beattie said that the presentation explained how the train station would be located right next to R.K. Miles making it assessable to the downtown area.
The presentation was given by Wendy Woods of the Southwest Vermont Passenger Rail Committee. She was unable to be contacted by press time for further comment.
The Vermont Agency of Transportation and the New York State Department of Transportation, in cooperation with the Federal Railroad Administration, have been conducting a New York - Vermont Bi-state intercity passenger rail study to identify opportunities to provide access to passenger rail service to parts of southwestern Vermont, including Manchester.
The project study area covers Rutland and Bennington Counties in southwestern Vermont and adjacent areas in eastern central New York, including Schenectady, Saratoga, Washington, Rensselaer, and Albany Counties. In order to minimize environmental impacts, the study will focus on opportunities for providing intercity passenger rail service along existing established rail corridors.
According to the website, the purpose of this project is to identify and establish an efficient, intercity passenger rail-based transportation link that will benefit unserved and under-served communities in southwestern Vermont and eastern central New York. The project would also provide a key link along Vermont's "Western Corridor", with improved connections to passenger rail services in New York and beyond via Albany and Schenectady, N.Y. For more information on the study visit www.ny-vt-passengerrail.org.
With the first Select Board meeting since the elections took place being held at the new Park House, Beattie said that he thinks Town Manager John O'Keefe wanted a chance to showcase the new building, which he said was very impressive.
Beattie said that the building is still under construction and that it is not currently open to the public.
During the meeting Beattie was reelected as chairman, Wayne Bell was reelected as vice-chairman and Lisa Souls was elected as clerk.
If you'd like to leave a comment (or a tip or a question) about this story with the editors, please email us. We also welcome letters to the editor for publication; you can do that by filling out our letters form and submitting it to the newsroom.


text:
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I know there have been many issues with this subject - but I forgot which thread it was in. I am hoping that someone can help me with my issue. I have a new dell (less than a year old) - plenty of hard drive space, plenty of memory, XP SP3, I have been running ZoneAlarm for about 3 years with no issues (other than the vsmon flaking out every now and again). Now ZA has updated to the latest version (8.059) and my pc will not restart or shutdown without me doing a hard shutdown (I have not had this issue prior to version 8)
I have unistalled ZA according to the thread (http://forums.zonealarm.org/zonelabs...ssage.id=54068) and I am still having the same issue with restarting/shutdown. I have not reinstalled ZA yet.
Does anyone have any ideas?
Operating System:Windows XP Home Edition
Software Version:8.0
Product Name:ZoneAlarm Internet Security Suite


text:
Strikeouts give Yankees an October edge
In regular season, pitching staff topped AL with 1,260 K's
By Anthony DiComo / MLB.com
"I really wanted to get Cuddyer out on a strikeout because I got ahead of him real quick, and I had a couple pitches to waste," Robertson said. "I just didn't make a great pitch."
Moments later, Robertson escaped from the bases-loaded, no-out jam with a combination of good luck and fortunate pitches. But his approach was not lost on the Yankees.
For the first time in years, the Yankees have a power pitching staff. From CC Sabathia and A.J. Burnett all the way down the depth chart to Robertson, the Yankees are capable of striking out batters at almost any time. And like home runs and stolen bases, that's a skill that carries even more weight in October.
"It's always good to have a strikeout guy," backup catcher Jose Molina said. "It takes away from the big innings. A lot of people like contact guys. I say more a strikeout guy will take you away from a lot of big innings."
No doubt, finesse pitchers have their merits. But nothing raises hair quite as much as a power pitcher in October, which -- even more so than because of their high-octane offense -- is why the Yankees are currently a feared team.
Four years ago, on their way to the first of three straight first-round exits, the Yankees struck out 985 batters during the regular season. This year, due in large part to free-agent acquisitions Sabathia and Burnett, the Yankees struck out 1,260 batters -- tops in the American League.
It starts, quite naturally, with the starters -- namely Sabathia and Burnett. Last year, Yankees starting pitchers ranked 19th in the Majors with 618 strikeouts. This year, they ranked sixth with 777 punch outs, nearly a full strikeout more per game.
Sabathia displayed those skills during Game 1 vs. Minnesota, striking out eight batters and walking none. Then it was Burnett, who punched out six batters in Game 2 -- four of them with men on base.
Twice, Burnett put those runners on base via one of his five walks, only to end each of those innings with strikeouts.
"When A.J. is on, no one is going to hit him," first baseman Mark Teixeira said. "That's just the way he is. He's just got such incredible stuff that if he's on his game, it's going to be a boring day for the fielders."
"You guys saw it," Burnett said. "I was pitching out of the stretch every inning. During the season, you raise eyebrows walking five batters -- that's a lot, blah, blah, blah. But in the postseason, it doesn't matter. If you make pitches when they count, those runs don't score. It's always good to have that confidence in the back of your mind that hopefully you can get a strikeout when you need it."
It's a mindset that is hardly limited to the rotation. Yankees relievers have also struck out more than a few batters this season, including Phil Hughes -- 65 strikeouts in 51 1/3 relief innings -- Mariano Rivera and Joba Chamberlain, now back in the bullpen for October baseball. Then there is Robertson, who made the postseason roster largely because of his ability to rack up strikeouts when needed.
Robertson, who whiffed 63 batters in just 43 2/3 innings this season, said he generally doesn't look for a strikeout until he has two strikes on a batter. Then he'll try to expand the strike zone, ramp up his fastball velocity -- anything to generate a swing and a miss.
"There are times when it can be a huge help," Robertson said. "With the bases loaded, you're supposed to strike people out."
Many around baseball, however, aren't so keen on the K. Because strikeouts require three pitches and usually use up quite a few more, they are a surefire way to escalate pitch counts -- a major problem at times for Burnett.
"I prefer we don't strike as many out," Yankees pitching coach Dave Eiland said. "But when we need a strikeout, we have guys who are capable of doing it."
Again and again and again. Against the Angels, a club full of pesky hitters who do not whiff too often, the Yankees may not be able to strike out batters with such proficiency. But they will certainly try.
"I give up a lot of hits," Robertson said. "I give up a lot of walks, too. So I guess strikeouts are a good way to get yourself out of those jams."
Anthony DiComo is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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