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Science, Astronomy and Research News
March 2017 Volume 49, Issue 3
The creativity of immigrants p319 doi:10.1038/ng.3814
The road to precision oncology pp320 - 321 Andrew V Biankin doi:10.1038/ng.3796The ultimate goal of precision medicine is to use population-based molecular, clinical and other data to make individually tailored clinical decisions for patients, although the path to achieving this goal is not entirely clear. A new study shows how knowledge banks of patient data can be used to make individual treatment decisions in acute myeloid leukemia.See also: Analysis by Gerstung et al.
Convergence and divergence in sex-chromosome evolution pp321 - 322 Catherine L Peichel doi:10.1038/ng.3797A sequence assembly of the chicken W chromosome enables reconstruction of the gene content of the W chromosome across 14 bird species and shows striking similarities in the maintenance of broadly expressed and dosage-sensitive genes on highly degenerate sex chromosomes in both birds and mammals. However, the chicken W chromosome is not enriched for genes with expression in female-specific tissues, providing an intriguing contrast to the acquisition and amplification of genes with testis-specific expression on mammalian Y chromosomes and suggesting that the inheritance of chromosomes solely through females or males can lead to different evolutionary outcomes.See also: Article by Bellott et al.
Untangling the genetics from the epigenetics in pancreatic cancer metastasis pp323 - 324 Christopher R Vakoc & David A Tuveson doi:10.1038/ng.3798Comparative genomic analyses of primary tumors and metastases within individuals with pancreatic cancer have exposed the complex clonal dynamics that underlie the dissemination of cancer cells to distant sites. Recent studies implicate non-genetic mechanisms in this process, particularly fluctuations in chromatin states and metabolism, which can endow rare cells within a primary tumor with metastatic potential.See also: Article by Makohon-Moore et al. | Article by McDonald et al.
Case-control association mapping by proxy using family history of disease pp325 - 331 Jimmy Z Liu, Yaniv Erlich & Joseph K Pickrell doi:10.1038/ng.3766Jimmy Liu and colleagues perform genome-wide association by proxy (GWAX) in a large population cohort by replacing cases with their first-degree relatives. They apply GWAX to 12 common diseases and show its utility by identifying new risk loci for Alzheimer's disease, coronary artery disease and type 2 diabetes.
Precision oncology for acute myeloid leukemia using a knowledge bank approach pp332 - 340 Moritz Gerstung, Elli Papaemmanuil, Inigo Martincorena, Lars Bullinger, Verena I Gaidzik, Peter Paschka, Michael Heuser, Felicitas Thol, Niccolo Bolli, Peter Ganly, Arnold Ganser, Ultan McDermott, Konstanze Döhner, Richard F Schlenk, Hartmut Döhner & Peter J Campbell doi:10.1038/ng.3756Peter Campbell, Hartmut Döhner and colleagues present an analysis of genetic mutations and clinical information from 1,540 patients with acute myeloid leukemia, demonstrating the utility of clinical knowledge banks for personalized medicine. They show that use of their approach could reduce the number of hematopoietic cell transplants in patients with AML by up to 25% while maintaining survival rates.See also: News and Views by Biankin
A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers pp341 - 348 Dominik Glodzik, Sandro Morganella, Helen Davies, Peter T Simpson, Yilong Li, Xueqing Zou, Javier Diez-Perez, Johan Staaf, Ludmil B Alexandrov, Marcel Smid, Arie B Brinkman, Inga Hansine Rye, Hege Russnes, Keiran Raine, Colin A Purdie, Sunil R Lakhani, Alastair M Thompson, Ewan Birney, Hendrik G Stunnenberg, Marc J van de Vijver, John W M Martens, Anne-Lise Børresen-Dale, Andrea L Richardson, Gu Kong, Alain Viari, Douglas Easton, Gerard Evan, Peter J Campbell, Michael R Stratton & Serena Nik-Zainal doi:10.1038/ng.3771Serena Nik-Zainal and colleagues present a detailed analysis of somatic rearrangements in 560 breast cancers. They highlight 33 rearrangement hotspots characterized mainly by large tandem duplications and show that these hotspots are enriched in breast cancer germline susceptibility loci and breast-specific super-enhancer elements.
Systematic analysis of telomere length and somatic alterations in 31 cancer types pp349 - 357 Floris P Barthel, Wei Wei, Ming Tang, Emmanuel Martinez-Ledesma, Xin Hu, Samirkumar B Amin, Kadir C Akdemir, Sahil Seth, Xingzhi Song, Qianghu Wang, Tara Lichtenberg, Jian Hu, Jianhua Zhang, Siyuan Zheng & Roel G W Verhaak doi:10.1038/ng.3781Siyuan Zheng, Roel Verhaak and colleagues report an analysis of telomere lengths and somatic alterations in telomere-related pathways across 31 cancer types. Their study provides an overview of the molecular mechanisms driving TERT expression and activation of the ALT pathway, and identifies a subset of tumors with neither detectable TERT expression nor somatic alterations in ATRX or DAXX.
Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer pp358 - 366 Alvin P Makohon-Moore, Ming Zhang, Johannes G Reiter, Ivana Bozic, Benjamin Allen, Deepanjan Kundu, Krishnendu Chatterjee, Fay Wong, Yuchen Jiao, Zachary A Kohutek, Jungeui Hong, Marc Attiyeh, Breanna Javier, Laura D Wood, Ralph H Hruban, Martin A Nowak, Nickolas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein & Christine A Iacobuzio-Donahue doi:10.1038/ng.3764Christine Iacobuzio-Donahue and colleagues report a detailed analysis of whole-genome sequencing data from primary and metastatic tumors in four patients with pancreatic cancer. They find that in each patient primary tumors and metastases have identical mutations in known driver genes.See also: News and Views by Vakoc & Tuveson | Article by McDonald et al.
Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis pp367 - 376 Oliver G McDonald, Xin Li, Tyler Saunders, Rakel Tryggvadottir, Samantha J Mentch, Marc O Warmoes, Anna E Word, Alessandro Carrer, Tal H Salz, Sonoko Natsume, Kimberly M Stauffer, Alvin Makohon-Moore, Yi Zhong, Hao Wu, Kathryn E Wellen, Jason W Locasale, Christine A Iacobuzio-Donahue & Andrew P Feinberg doi:10.1038/ng.3753Andrew Feinberg, Christine Iacobuzio-Donahue and colleagues describe the epigenomic reprogramming that occurs during pancreatic cancer progression. They also show that hematogenous metastases co-evolve a dependence on the oxidative branch of the pentose phosphate pathway (oxPPP) and that oxPPP inhibition reverses chromatin reprogramming and blocks tumorigenic potential.See also: News and Views by Vakoc & Tuveson | Article by Makohon-Moore et al.
Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells pp377 - 386 Jin Xu, Ava C Carter, Anne-Valerie Gendrel, Mikael Attia, Joshua Loftus, William J Greenleaf, Robert Tibshirani, Edith Heard & Howard Y Chang doi:10.1038/ng.3769Howard Chang and colleagues use allele-specific ATAC-seq to profile active regulatory DNA across the genome in mouse embryonic stem cells and neural progenitor cells. They find that monoallelic DNA accessibility across autosomes is pervasive, developmentally programmed and composed of several patterns.
Avian W and mammalian Y chromosomes convergently retained dosage-sensitive regulators pp387 - 394 Daniel W Bellott, Helen Skaletsky, Ting-Jan Cho, Laura Brown, Devin Locke, Nancy Chen, Svetlana Galkina, Tatyana Pyntikova, Natalia Koutseva, Tina Graves, Colin Kremitzki, Wesley C Warren, Andrew G Clark, Elena Gaginskaya, Richard K Wilson & David C Page doi:10.1038/ng.3778David Page and colleagues report the sequence of the chicken W sex chromosome and compare ancestral W-linked genes across bird species. They find that the W chromosome did not acquire genes expressed exclusively in reproductive tissue, but retained genes through selection to maintain appropriate dosage levels of broadly expressed genes.See also: News and Views by Peichel
Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance pp395 - 402 Abigail L Manson, Keira A Cohen, Thomas Abeel, Christopher A Desjardins, Derek T Armstrong, Clifton E Barry III, Jeannette Brand, TBResist Global Genome Consortium, Sinéad B Chapman, Sang-Nae Cho, Andrei Gabrielian, James Gomez, Andreea M Jodals, Moses Joloba, Pontus Jureen, Jong Seok Lee, Lesibana Malinga, Mamoudou Maiga, Dale Nordenberg, Ecaterina Noroc, Elena Romancenco, Alex Salazar, Willy Ssengooba, A A Velayati, Kathryn Winglee, Aksana Zalutskaya, Laura E Via, Gail H Cassell, Susan E Dorman, Jerrold Ellner, Parissa Farnia, James E Galagan, Alex Rosenthal, Valeriu Crudu, Daniela Homorodean, Po-Ren Hsueh, Sujatha Narayanan, Alexander S Pym, Alena Skrahina, Soumya Swaminathan, Martie Van der Walt, David Alland, William R Bishai, Ted Cohen, Sven Hoffner, Bruce W Birren & Ashlee M Earl doi:10.1038/ng.3767Ashlee Earl and colleagues analyze whole-genome sequences from 5,310 Mycobacterium tuberculosis isolates from five continents. They find that resistance to isoniazid arises before rifampicin resistance across all of the lineages, geographical regions and time periods.
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk pp403 - 415 Helen R Warren, Evangelos Evangelou, Claudia P Cabrera, He Gao, Meixia Ren, Borbala Mifsud, Ioanna Ntalla, Praveen Surendran, Chunyu Liu, James P Cook, Aldi T Kraja, Fotios Drenos, Marie Loh, Niek Verweij, Jonathan Marten, Ibrahim Karaman, Marcelo P Segura Lepe, Paul F O'Reilly, Joanne Knight, Harold Snieder, Norihiro Kato, Jiang He, E Shyong Tai, M Abdullah Said, David Porteous, Maris Alver, Neil Poulter, Martin Farrall, Ron T Gansevoort, Sandosh Padmanabhan, Reedik Mägi, Alice Stanton, John Connell, Stephan J L Bakker, Andres Metspalu, Denis C Shields, Simon Thom, Morris Brown, Peter Sever, Tõnu Esko, Caroline Hayward, Pim van der Harst, Danish Saleheen, Rajiv Chowdhury, John C Chambers, Daniel I Chasman, Aravinda Chakravarti, Christopher Newton-Cheh, Cecilia M Lindgren, Daniel Levy, Jaspal S Kooner, Bernard Keavney, Maciej Tomaszewski, Nilesh J Samani, Joanna M M Howson, Martin D Tobin, Patricia B Munroe, Georg B Ehret, Louise V Wain, Louise V Wain, Ahmad Vaez, Rick Jansen, Roby Joehanes, Peter J van der Most, A Mesut Erzurumluoglu, Paul O'Reilly, Claudia P Cabrera, Helen R Warren, Lynda M Rose, Germaine C Verwoert, Jouke-Jan Hottenga, Rona J Strawbridge, Tonu Esko, Dan E Arking, Shih-Jen Hwang, Xiuqing Guo, Zoltan Kutalik, Stella Trompet, Nick Shrine, Alexander Teumer, Janina S Ried, Joshua C Bis, Albert V Smith, Najaf Amin, Ilja M Nolte, Leo-Pekka Lyytikäinen, Anubha Mahajan, Nicholas J Wareham, Edith Hofer, Peter K Joshi, Kati Kristiansson, Michela Traglia, Aki S Havulinna, Anuj Goel, Mike A Nalls, Siim Sõber, Dragana Vuckovic, Jian'an Luan, Fabiola Del Greco M, Kristin L Ayers, Jaume Marrugat, Daniela Ruggiero, Lorna M Lopez, Teemu Niiranen, Stefan Enroth, Anne U Jackson, Christopher P Nelson, Jennifer E Huffman, Weihua Zhang, Jonathan Marten, Ilaria Gandin, Sarah E Harris, Tatijana Zemonik, Yingchang Lu, Evangelos Evangelou, Nabi Shah, Martin H de Borst, Massimo Mangino, Bram P Prins, Archie Campbell, Ruifang Li-Gao, Ganesh Chauhan, Christopher Oldmeadow, Gonçalo Abecasis, Maryam Abedi, Caterina M Barbieri, Michael R Barnes, Chiara Batini, BIOS Consortium, Tineka Blake, Michael Boehnke, Erwin P Bottinger, Peter S Braund, Morris Brown, Marco Brumat, Harry Campbell, John C Chambers, Massimiliano Cocca, Francis Collins, John Connell, Heather J Cordell, Jeffrey J Damman, Gail Davies, Eco J de Geus, Renée de Mutsert, Joris Deelen, Yusuf Demirkale, Alex S F Doney, Marcus Dörr, Martin Farrall, Teresa Ferreira, Mattias Frånberg, He Gao, Vilmantas Giedraitis, Christian Gieger, Franco Giulianini, Alan J Gow, Anders Hamsten, Tamara B Harris, Albert Hofman, Elizabeth G Holliday, Marjo-Riitta Jarvelin, Åsa Johansson, Andrew D Johnson, Pekka Jousilahti, Antti Jula, Mika Kähönen, Sekar Kathiresan, Kay-Tee Khaw, Ivana Kolcic, Seppo Koskinen, Claudia Langenberg, Marty Larson, Lenore J Launer, Benjamin Lehne, David C M Liewald, Lifelines Cohort Study, Li Lin, Lars Lind, François Mach, Chrysovalanto Mamasoula, Cristina Menni, Borbala Mifsud, Yuri Milaneschi, Anna Morgan, Andrew D Morris, Alanna C Morrison, Peter J Munson, Priyanka Nandakumar, Quang Tri Nguyen, Teresa Nutile, Albertine J Oldehinkel, Ben A Oostra, Elin Org, Sandosh Padmanabhan, Aarno Palotie, Guillaume Paré, Alison Pattie, Brenda W J H Penninx, Neil Poulter, Peter P Pramstaller, Olli T Raitakari, Meixia Ren, Kenneth Rice, Paul M Ridker, Harriëtte Riese, Samuli Ripatti, Antonietta Robino, Jerome I Rotter, Igor Rudan, Yasaman Saba, Aude Saint Pierre, Cinzia F Sala, Antti-Pekka Sarin, Reinhold Schmidt, Rodney Scott, Marc A Seelen, Denis C Shields, David Siscovick, Rossella Sorice, Alice Stanton, David J Stott, Johan Sundström, Morris Swertz, Kent D Taylor, Simon Thom, Ioanna Tzoulaki, Christophe Tzourio, André G Uitterlinden, Understanding Society Scientific group, Uwe Völker, Peter Vollenweider, Sarah Wild, Gonneke Willemsen, Alan F Wright, Jie Yao, Sébastien Thériault, David Conen, Attia John, Peter Sever, Stéphanie Debette, Dennis O Mook-Kanamori, Eleftheria Zeggini, Tim D Spector, Pim van der Harst, Colin N A Palmer, Anne-Claire Vergnaud, Ruth J F Loos, Ozren Polasek, John M Starr, Giorgia Girotto, Caroline Hayward, Jaspal S Kooner, Cecila M Lindgren, Veronique Vitart, Nilesh J Samani, Jaakko Tuomilehto, Ulf Gyllensten, Paul Knekt, Ian J Deary, Marina Ciullo, Roberto Elosua, Bernard D Keavney, Andrew A Hicks, Robert A Scott, Paolo Gasparini, Maris Laan, YongMei Liu, Hugh Watkins, Catharina A Hartman, Veikko Salomaa, Daniela Toniolo, Markus Perola, James F Wilson, Helena Schmidt, Jing Hua Zhao, Terho Lehtimäki, Cornelia M van Duijn, Vilmundur Gudnason, Bruce M Psaty, Annette Peters, Rainer Rettig, Alan James, J Wouter Jukema, David P Strachan, Walter Palmas, Andres Metspalu, Erik Ingelsson, Dorret I Boomsma, Oscar H Franco, Murielle Bochud, Christopher Newton-Cheh, Patricia B Munroe, Paul Elliott, Daniel I Chasman, Aravinda Chakravarti, Joanne Knight, Andrew P Morris, Daniel Levy, Martin D Tobin, Harold Snieder, Mark J Caulfield & Georg B Ehret for The International Consortium of Blood Pressure (ICBP) 1000G Analyses, The CHD Exome+ Consortium, The ExomeBP Consortium, The T2D-GENES Consortium, The GoT2DGenes Consortium, The Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium, The International Genomics of Blood Pressure (iGEN-BP) Consortium & Michael R Barnes, Ioanna Tzoulaki, Mark J Caulfield & Paul Elliott for The UK Biobank CardioMetabolic Consortium BP working group doi:10.1038/ng.3768Mark Caulfield, Paul Elliott and colleagues use data from the UK Biobank to perform genome-wide association analysis for blood pressure traits. They identify and validate 107 novel loci and highlight new biological pathways for potential therapeutic intervention for hypertension.
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets pp416 - 425 Louise V Wain, Nick Shrine, María Soler Artigas, A Mesut Erzurumluoglu, Boris Noyvert, Lara Bossini-Castillo, Ma'en Obeidat, Amanda P Henry, Michael A Portelli, Robert J Hall, Charlotte K Billington, Tracy L Rimington, Anthony G Fenech, Catherine John, Tineka Blake, Victoria E Jackson, Richard J Allen, Bram P Prins, Understanding Society Scientific Group, Archie Campbell, David J Porteous, Marjo-Riitta Jarvelin, Matthias Wielscher, Alan L James, Jennie Hui, Nicholas J Wareham, Jing Hua Zhao, James F Wilson, Peter K Joshi, Beate Stubbe, Rajesh Rawal, Holger Schulz, Medea Imboden, Nicole M Probst-Hensch, Stefan Karrasch, Christian Gieger, Ian J Deary, Sarah E Harris, Jonathan Marten, Igor Rudan, Stefan Enroth, Ulf Gyllensten, Shona M Kerr, Ozren Polasek, Mika Kähönen, Ida Surakka, Veronique Vitart, Caroline Hayward, Terho Lehtimäki, Olli T Raitakari, David M Evans, A John Henderson, Craig E Pennell, Carol A Wang, Peter D Sly, Emily S Wan, Robert Busch, Brian D Hobbs, Augusto A Litonjua, David W Sparrow, Amund Gulsvik, Per S Bakke, James D Crapo, Terri H Beaty, Nadia N Hansel, Rasika A Mathias, Ingo Ruczinski, Kathleen C Barnes, Yohan Bossé, Philippe Joubert, Maarten van den Berge, Corry-Anke Brandsma, Peter D Paré, Don D Sin, David C Nickle, Ke Hao, Omri Gottesman, Frederick E Dewey, Shannon E Bruse, David J Carey, H Lester Kirchner, Geisinger-Regeneron DiscovEHR Collaboration, Stefan Jonsson, Gudmar Thorleifsson, Ingileif Jonsdottir, Thorarinn Gislason, Kari Stefansson, Claudia Schurmann, Girish Nadkarni, Erwin P Bottinger, Ruth J F Loos, Robin G Walters, Zhengming Chen, Iona Y Millwood, Julien Vaucher, Om P Kurmi, Liming Li, Anna L Hansell, Chris Brightling, Eleftheria Zeggini, Michael H Cho, Edwin K Silverman, Ian Sayers, Gosia Trynka, Andrew P Morris, David P Strachan, Ian P Hall & Martin D Tobin doi:10.1038/ng.3787Louise Wain, Ian Hall, Martin Tobin and colleagues report genome-wide association analyses of lung function, identifying 43 new signals associated with one or more lung function traits. A genetic risk score derived from these results was significantly associated with risk for chronic obstructive pulmonary disease in independent populations.
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis pp426 - 432 Brian D Hobbs, Kim de Jong, Maxime Lamontagne, Yohan Bossé, Nick Shrine, María Soler Artigas, Louise V Wain, Ian P Hall, Victoria E Jackson, Annah B Wyss, Stephanie J London, Kari E North, Nora Franceschini, David P Strachan, Terri H Beaty, John E Hokanson, James D Crapo, Peter J Castaldi, Robert P Chase, Traci M Bartz, Susan R Heckbert, Bruce M Psaty, Sina A Gharib, Pieter Zanen, Jan W Lammers, Matthijs Oudkerk, H J Groen, Nicholas Locantore, Ruth Tal-Singer, Stephen I Rennard, Jørgen Vestbo, Wim Timens, Peter D Paré, Jeanne C Latourelle, Josée Dupuis, George T O'Connor, Jemma B Wilk, Woo Jin Kim, Mi Kyeong Lee, Yeon-Mok Oh, Judith M Vonk, Harry J de Koning, Shuguang Leng, Steven A Belinsky, Yohannes Tesfaigzi, Ani Manichaikul, Xin-Qun Wang, Stephen S Rich, R Graham Barr, David Sparrow, Augusto A Litonjua, Per Bakke, Amund Gulsvik, Lies Lahousse, Guy G Brusselle, Bruno H Stricker, André G Uitterlinden, Elizabeth J Ampleford, Eugene R Bleecker, Prescott G Woodruff, Deborah A Meyers, Dandi Qiao, David A Lomas, Jae-Joon Yim, Deog Kyeom Kim, Iwona Hawrylkiewicz, Pawel Sliwinski, Megan Hardin, Tasha E Fingerlin, David A Schwartz, Dirkje S Postma, William MacNee, Martin D Tobin, Edwin K Silverman, H Marike Boezen, Michael H Cho, COPDGene Investigators, ECLIPSE Investigators, LifeLines Investigators, SPIROMICS Research Group, International COPD Genetics Network Investigators, UK BiLEVE Investigators & International COPD Genetics Consortium doi:10.1038/ng.3752Michael Cho and colleagues report a genome-wide association study of risk for chronic obstructive pulmonary disease (COPD) in a large, multi-ancestry cohort. They identify 22 genome-wide significant loci, including 13 not previously associated with COPD and 4 not previously associated with any lung function trait.
A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases pp433 - 437 Jian Zhao, Jianyang Ma, Yun Deng, Jennifer A Kelly, Kwangwoo Kim, So-Young Bang, Hye-Soon Lee, Quan-Zhen Li, Edward K Wakeland, Rong Qiu, Mengru Liu, Jianping Guo, Zhanguo Li, Wenfeng Tan, Astrid Rasmussen, Christopher J Lessard, Kathy L Sivils, Bevra H Hahn, Jennifer M Grossman, Diane L Kamen, Gary S Gilkeson, Sang-Cheol Bae, Patrick M Gaffney, Nan Shen & Betty P Tsao doi:10.1038/ng.3782Betty Tsao, Jian Zhao, Nan Shen and colleagues show that a common missense variant in NCF1 confers susceptibility to multiple autoimmune diseases. This variant, which leads to reduced production of reactive oxygen species, accounts for the strong association signal previously identified in the GTF2IRD1-GTF2I region at 7q11.23.
Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behcet's disease susceptibility pp438 - 443 Masaki Takeuchi, Nobuhisa Mizuki, Akira Meguro, Michael J Ombrello, Yohei Kirino, Colleen Satorius, Julie Le, Mary Blake, Burak Erer, Tatsukata Kawagoe, Duran Ustek, Ilknur Tugal-Tutkun, Emire Seyahi, Yilmaz Ozyazgan, Inês Sousa, Fereydoun Davatchi, Vânia Francisco, Farhad Shahram, Bahar Sadeghi Abdollahi, Abdolhadi Nadji, Niloofar Mojarad Shafiee, Fahmida Ghaderibarmi, Shigeaki Ohno, Atsuhisa Ueda, Yoshiaki Ishigatsubo, Massimo Gadina, Sofia A Oliveira, Ahmet Gül, Daniel L Kastner & Elaine F Remmers doi:10.1038/ng.3786Daniel Kastner, Elaine Remmers and colleagues perform an association study of Behcet's disease based on dense genotyping of immune-related loci. They identify new association signals near genes involved in host response to microbial exposure and extend evidence for shared susceptibility loci with Crohn's disease and leprosy.
Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer pp444 - 450 Luca Magnani, Gianmaria Frigè, Raffaella Maria Gadaleta, Giacomo Corleone, Sonia Fabris, Hermannus Kempe, Pernette J Verschure, Iros Barozzi, Valentina Vircillo, Sung-Pil Hong, Ylenia Perone, Massimo Saini, Andreas Trumpp, Giuseppe Viale, Antonino Neri, Simak Ali, Marco Angelo Colleoni, Giancarlo Pruneri & Saverio Minucci doi:10.1038/ng.3773Saverio Minucci, Giancarlo Pruneri, Luca Magnani and colleagues identify acquired CYP19A1 amplification as a mechanism of resistance to aromatase inhibitors in ERα metastatic breast cancer. Mechanistically, they show that CYP19A1 amplification results in increased aromatase activity and estrogen-independent ERα binding to target genes.
Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes pp451 - 456 Jasmijn D E de Rooij, Cristyn Branstetter, Jing Ma, Yongjin Li, Michael P Walsh, Jinjun Cheng, Askar Obulkasim, Jinjun Dang, John Easton, Lonneke J Verboon, Heather L Mulder, Martin Zimmermann, Cary Koss, Pankaj Gupta, Michael Edmonson, Michael Rusch, Joshua Yew Suang Lim, Katarina Reinhardt, Martina Pigazzi, Guangchun Song, Allen Eng Juh Yeoh, Lee-Yung Shih, Der-Cherng Liang, Stephanie Halene, Diane S Krause, Jinghui Zhang, James R Downing, Franco Locatelli, Dirk Reinhardt, Marry M van den Heuvel-Eibrink, C Michel Zwaan, Maarten Fornerod & Tanja A Gruber doi:10.1038/ng.3772Franco Locatelli, Dirk Reinhardt, Marry van den Heuvel-Eibrink, C Michel Zwaan, Maarten Fornerod, Tanja Gruber and colleagues report whole-exome and transcriptome sequencing of acute megakaryoblastic leukemia from pediatric and adult patients without Down syndrome (non-DS-AMKL). They find that pediatric non-DS-AMKL can be divided into seven subgroups characterized by chimeric oncogenes with cooperating mutations in epigenetic and kinase signaling genes.
Biallelic mutations in the 3′ exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing pp457 - 464 Rea M Lardelli, Ashleigh E Schaffer, Veerle R C Eggens, Maha S Zaki, Stephanie Grainger, Shashank Sathe, Eric L Van Nostrand, Zinayida Schlachetzki, Basak Rosti, Naiara Akizu, Eric Scott, Jennifer L Silhavy, Laura Dean Heckman, Rasim Ozgur Rosti, Esra Dikoglu, Anne Gregor, Alicia Guemez-Gamboa, Damir Musaev, Rohit Mande, Ari Widjaja, Tim L Shaw, Sebastian Markmiller, Isaac Marin-Valencia, Justin H Davies, Linda de Meirleir, Hulya Kayserili, Umut Altunoglu, Mary Louise Freckmann, Linda Warwick, David Chitayat, Susan Blaser, Ahmet Okay Çağlayan, Kaya Bilguvar, Huseyin Per, Christina Fagerberg, Henrik T Christesen, Maria Kibaek, Kimberly A Aldinger, David Manchester, Naomichi Matsumoto, Kazuhiro Muramatsu, Hirotomo Saitsu, Masaaki Shiina, Kazuhiro Ogata, Nicola Foulds, William B Dobyns, Neil C Chi, David Traver, Luigina Spaccini, Stefania Maria Bova, Stacey B Gabriel, Murat Gunel, Enza Maria Valente, Marie-Cecile Nassogne, Eric J Bennett, Gene W Yeo, Frank Baas, Jens Lykke-Andersen & Joseph G Gleeson doi:10.1038/ng.3762Jens Lykke-Andersen, Frank Baas, Joseph Gleeson and colleagues report that mutations in the 3′ exonuclease TOE1 cause pontocerebellar hypoplasia type 7. They further show that these mutations result in the accumulation of incompletely processed small nuclear RNAs, leading to severe, early-onset neurodegeneration.
Divergent effects of intrinsically active MEK variants on developmental Ras signaling pp465 - 469 Yogesh Goyal, Granton A Jindal, José L Pelliccia, Kei Yamaya, Eyan Yeung, Alan S Futran, Rebecca D Burdine, Trudi Schüpbach & Stanislav Y Shvartsman doi:10.1038/ng.3780Stanislav Shvartsman and colleagues quantify signaling changes caused by disease-associated mutations in MAP2K1 (encoding MEK) in fruit fly and zebrafish embryos. They find that intrinsically active MEK variants can both increase and reduce the levels of pathway activation depending on cellular context.
Whole-genome analysis of introgressive hybridization and characterization of the bovine legacy of Mongolian yaks pp470 - 475 Ivica Medugorac, Alexander Graf, Cécile Grohs, Sophie Rothammer, Yondon Zagdsuren, Elena Gladyr, Natalia Zinovieva, Johanna Barbieri, Doris Seichter, Ingolf Russ, André Eggen, Garrett Hellenthal, Gottfried Brem, Helmut Blum, Stefan Krebs & Aurélien Capitan doi:10.1038/ng.3775Ivica Medugorac, Aurélien Capitan and colleagues use high-density SNP genotyping and whole-genome sequencing to infer bovine haplotypes in the genomes of 76 Mongolian yaks. They show that these introgressed regions are enriched for genes involved in nervous system development and function, supporting the idea that introgressive hybridization contributed to the improvement of yak management and breeding.
A study of allelic diversity underlying flowering-time adaptation in maize landraces pp476 - 480 J Alberto Romero Navarro, Martha Willcox, Juan Burgueño, Cinta Romay, Kelly Swarts, Samuel Trachsel, Ernesto Preciado, Arturo Terron, Humberto Vallejo Delgado, Victor Vidal, Alejandro Ortega, Armando Espinoza Banda, Noel Orlando Gómez Montiel, Ivan Ortiz-Monasterio, Félix San Vicente, Armando Guadarrama Espinoza, Gary Atlin, Peter Wenzl, Sarah Hearne & Edward S Buckler doi:10.1038/ng.3784Edward Buckler, Sarah Hearne and colleagues integrate two approaches to characterize the genetic diversity of a large number of geographically distributed maize landraces. They examine flowering time and adaptation to altitude and find that the majority of the associated SNPs overlap both traits.
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I know - I haven't been around for EVER! And it likely won't get any better any time soon.
If you are going to the OOAK show in TO at the end of March. My hats will be making a guest appearance with some cute dresses. They won't be under my tags...but they will be mine! Meep. So excited.
Now all I have to do is finish up a bunch of orders so I can rock as many hats as possible to go to the show!
Monday, March 14, 2011
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Check out news, politics, great food, funny political humor, sassy opinion, astronomy and science, great quotes, awesome photography, poetry and spiritual thoughts.
From Denny: Sometimes, I think if I didn't do posts roundup on all these crazy blogs I would never realize just how much I've been writing or on what subjects as the writing moves so quickly. The news is running at a rapid rate these days with all the revolutions in the Middle East and destructive world weather.
Fortunately, we have the comedians and the chefs to perk up our spirits and tantalize our taste buds so we don't get overwhelmed with too much negativity in the news and our politics. It's all about balance to live in the world but not be of the world. Besides, my cartoon collection must be massive by now after two years of blogging as I publish several hundred a month.
How about that Super Moon this week? Wow! Was it outstanding in some parts of the world. I found some awesome photos that I posted over at Visual Insights, the photo blog. It was fun to write the science post over at The Soul Calendar about this infrequent visitor, the Super Moon.
But what really rang everyone's chimes was the Super Moon post over at Beautiful Illustrated Quotations where I discussed the spiritual and symbolic meaning of the Super Moon. When I started that spiritual quotes blog I really never realized just how many people would be so interested. Uh oh, blogging may be my new sport of choice. :)
Take a look around and see what interests you. And to those of you who are regular readers and subscribers, thank you so much for your continued support!
The most recent posts roundup on all the blogs:
Posts Roundup at Dennys Blogs - 28 Feb 2011
Posts Roundup at Dennys Blogs - 13 Feb 2011
Posts Roundup at Dennys Blogs - 30 Jan 2011
72 Posts Roundup at Dennys Blogs - 20 Dec 2010
Dennys: News Politics Comedy Science Arts & Food
3 Funny St. Patricks Day Posts, Lots of Quotes
The Social Poets - news and political humor
Obama: End Libya War Now and 14 Political Cartoons
56 Political Fitness Comedy American Style Cartoons
Japan: Nuclear Update, 20 Japan Political Cartoons
Newt Gingrich Cartoons: Newtie 4 President - NOT!
Japan: Plutonium Reactor Careening Out of Control, 18 Political Cartoons
Japan: Thousands Flee From Terror of Deteriorating Nuclear Situation
Japan: Nuclear Update, Earthquake, Tsunami, Nuclear Political Cartoons
Japan: Nuclear Plants in Peril 3 Days After 9.0 Earthquake, Tsunami
Japan: Lying About Nuke Plant Meltdowns, Evacuate Americans
Wisconsin: Update, The Peoples Uprising Cartoons - 11 Mar 2011
Funny But True: Exorcist Chasing Demons Out of Big Bank Chase
Wisconsin: Dark Side Karl Rove, GOP War On Working Families, Anti-Union Ad
Wisconsin Poll: Gov. Walker Gets Thumbs Down From Voters
America Is NOT Broke Wisconsin Speech: Activist Michael Moore
Peoples Revolution: Wisconsin Update and Political Cartoons
Women in Peril: Ivory Coast Protesters
Do You Know Your Governors Donor List?
Dennys Global Politics:
Libya Update: No-Fly Zone Allies Pound Gadafi Forces Over Weekend
Libya Update and 23 Political Cartoons - 5 Mar 2011
Libya News Update: Political Cartoons of Gadhafi Last Stand
Beautiful Illustrated Quotations:
Super Moon: Symbolic Spiritual Meaning
What Value Do We Place On Alone Time?
Most Popular at Beautiful Illustrated Quotations:
2012: What Will Happen to Earth and Us?
111 Insightful Life Quotes
11 Great Quotes and Sayings Photos
Restful: 16 Beautiful Creative Angel Photos
Funny Mardi Gras Quotes, Who Dat Rocking Saints Songs
Meditative Moon Photos
A Poem Of Remembrance
Mothers Day Quote From Rose Kennedy
17 Short Beautiful Love Poems
26 Funny Political Cartoons - 6 Feb 2010
Most Beautiful Quotes
Popular Posts 2010 at Beautiful Illustrated Quotations and Thank You!
Popular Posts 2009 @ Beautiful Illustrated Quotations and Thank You!
Dennys People Watching:
34 Oscars Celebs, Gowns, Hair, Gift Bags For 2011
Music Video: Britney Spears Song Spoof - Hold It Against Me
The Soul Calendar:
Super Moon Phenomenon: Gorgeous Illusion Worth Watching
Beautiful Illustrated Quotations: Super Moon: Symbolic Spiritual Meaning
The Social Poets: Updates: Wisconsin, Islamaphobia, Newsman David Broder and Political Cartoons
The Social Poets: Japan: Plutonium Reactor Careening Out of Control, 18 Political Cartoons
The Social Poets: Japan: Nuclear Update, Earthquake, Tsunami, Nuclear Political Cartoons
Memory Tricks For Your Brain: Visualizing
Music: Training Your Brain to Concentrate Better
24 Funny Witty Technology Wallpapers
National Day of Unplugging 2011 and Funny Tech Cartoons
Surprise: Formerly Bald Mice Show How To Regrow Hair?
Cosmic Bloodhound: Hubble Telescope Finds Distant Ancient Galaxy?
Funny Technology Cartoons - 20 Feb 2011
Most Popular at The Soul Calendar
Cosmic Bloodhound: Hubble Telescope Finds Distant Ancient Galaxy?
Popular Funny X-ray Pin-Ups Calendar: Stripped to the Bone
How Northern Lights Are Created By Sun Flares
Funny Political Cartoons This Week 30 Jan 2010
BP Oil Spill and WikiLeaks Spill Cartoons - 7 Aug 2010
Rare 500 Year Lunar Eclipse Gets Viewed By 1.5 Billion
51 Funny Political Cartoons - Sex Scandals, Rove, Obama, Health Care, Tea Party - 27 Mar 2010
Gulf Coast Oil Rig Disaster Slammed: Political Cartoons 1 May 2010
BP Oil Spill and Global Warming Cartoons - 14 Aug 2010
Photo by Tansan @ flickr
Dennys Funny Quotes:
2 Funny Freud Cartoons From Raymond Betancourt
Funny Cartoon: Tinker Bell, We Hardly Knew Ye
18 Funny Satire Cartoons: The Old, Really Old, Pride
Funny Cartoon: Twisted Version of Garden of Eden
Funny Video: Colbert Report Version of Mardi Gras, International Womens Day
Most popular at Dennys Funny Quotes:
Funny Video: Potty Training Your Sloth
14 Funny Charlie Sheen Cartoons
42 Monday Morning Funny Coffee Quotes, Coffee Cartoon
30 Funny Creative Animal Ads
25 Funny Quotes about Jokes and Politics
Check Out Funny Fat Tuesday Afterglow Photos and Quotes
Funny Family Quotes
42 Monday Morning Funny Coffee Quotes, Coffee Cartoon
Funny Mardi Gras Quotes, Who Dat Rocking Saints Songs
25 Ridiculously Funny Celebrity Duck Face Photos
10 Funny Work Quotes for Monday Morning
New Years: Funny Quotes, Resolutions Tips, Poems
Funny Housework Quotes
Funny Crazy Cat Quotes" & Funny Crazy Cat Quotes
Popular Posts 2010
Popular Posts 2009
Ouch Outrageous Obnoxious And Odd:
2 Outrageously Funny Vampire Cartoons From Raymond Betancourt
Most Popular
Quote About Humor in Life
Funny Facebook Cartoons
Funny Odd Couples: Cats and Their Weirdo Friends
Funny Essay on Why Santa Must Really Be A Woman
51 Funny Political Cartoons - Sex Scandals, Rove, Obama, Health Care, Tea Party - 27 Mar 2010
New Years: Funny Quotes, Resolutions Tips, Poems
5 Funny Thanksgiving Quotes, Photos
9 Funny Socially Inappropriate Store Signs
Outrageous Funny Photos: This Is So Wrong...
College Grads Chances of Finding Jobs: Political Cartoons
Popular Posts 2010 at Dennys Funny Quotes
Dennys Art Sanctuary:
38 Creative March Desktop Wallpapers
Funny Art: Reading The Directions
Funny Art: Dressing Up The Donkeys
Amusing Art Photo of The Day: Word Playing
Amazing Portrait Art Photo of The Day: Lady Gaga
Amusing Art Photo of The Day: 9 March 2011
Amusing Art Photo of The Day: 8 March 2011
Amusing Art Photo of The Day: 7 Mar 2011
Visual Insights: Dennys Funny Photo Gallery: The Nose Knows
Visual Insights:
Dennys Photo Gallery: 2011 Super Moon World Photos
Dennys Photo Gallery: Invisible Women Around The World - International Womens Day
Art Photo of The Day: Elegant Elephants At Sunset
Art Photo of The Day: Mont Saint Michel
Music Video: Bruno Mars - Grenade
Music Video: Bruno Mars - Just The Way You Are
Amazing Portrait Art Photo of The Day: Marilyn Monroe
Dennys Food and Recipes:
Grilling Steaks: Tips, Cooking Times, Great Sauces
Readers Recipes: Apple Upside-Down Caramel Cake, Louises Birthday Cake
From Chef Ina Garten, the Barefoot Contessa: Roasted Turkey Roulade, Sweet Potato Fries
Valentines Day: Romantic Meal From Chef Ina Garten
Valentines Day: Foolproof Chocolate Soufflé
Most Popular at Dennys Food and Recipes:
Cake Tuesday: Chef Bobby Flays Throwdown Competition Carrot Cake, Coconut Cake
Chef Lidia Bastianich: Easy Italian Christmas Cookie Recipes
Valentines Day Recipes: 3 Easy Creative Chocolate Cakes
Chef Emeril Cooks Holiday Menu: 7 Delicious Recipes
Cake Tuesday: Super Sweet Heavenly Hash Cake
Cake Tuesday: Buttermilk Fudge Cake With Chocolate Gloss Icing
Chocolate: Penne Pasta with Chocolate and Anchovies
Chocolate Bread Pudding in a Slow Cooker
Martha Stewart Thanksgiving Recipes: Pumpkin Bread Pudding, Pumpkin Donut Muffins
Drink: Chocolate Martini
*** THANKS for visiting, feel welcome to drop a comment or opinion, enjoy bookmarking this post on your favorite social site, a big shout out to awesome current subscribers – and if you are new to this blog, please subscribe in a reader or by email updates!
*** Come by for a visit and check out my other blogs:
*** Check out Holiday Recipes From Dennys Food and Recipes
Dennys Global Politics
The Social Poets - news, politics, political cartoon humor
The Soul Calendar - science, astronomy, psychology
Visual Insights - photos, art, music
Dennys Art Sanctuary
Beautiful Illustrated Quotations - spiritual quotes, philosophy
Best Spiritual Posts - my own best as well as links to other spiritual posts from all viewpoints
Poems From A Spiritual Heart - poetry
The Healing Waters - health news
Dennys People Watching - people in the news
Dennys Food and Recipes
Romancing The Chocolate - chocolate recipes and more food
Unusual 2 Tasty - different twists on favorite foods and international
Comfort Food From Louisiana - Cajun, seafood and more comfort food goodies
Dennys Funny Quotes - humor
Ouch Outrageous Obnoxious And Odd - more crazy humor
Dennys Blog Feeds - see what's posting at all Denny's blogs at a glance
Dennys: News Politics Comedy Science Arts Food - an online newspaper
Tired of homogenized boring journalism? Yeah, me too - which is why I started writing all these blogs. Deep thinking of the news and how it affects our lives along with lots of humor posts and much more from my 24 blogs. A free to read online newspaper from Independent journalist blogger Denny Lyon. Sit back, relax, get informed, cook a little and laugh a lot.
All Denny Lyon Blogs
- Dennys World News - updates daily on monthly posts collecting US and world news links focused upon global security
- A Truth Journal - news opinion about US and world politics
- Dennys Global Politics - US and world politics, presidential speeches, press releases
- Dennys Funny Quotes - most popular humor blog suitable for general audiences
- The Social Poets - flagship blog that spun off all the other niche blogs, Social Issue Poet (SIP)
- Poems From A Spiritual Heart - general spiritual thoughts, life philosophy paired with photography, exploring spiritual path
- A Christmas Post - where you can enjoy Christmas all year long, collection of my best Christmas posts on music, funny stories, poems and more
- Beautiful Illustrated Quotations - inspirational quotes, counsel, paired with photography
- Best Spiritual Posts - place to collect my best posts on spiritual counsel, spiritual music, connect to other sites offering food for thought
- Warriors Pearl Foundation - started up to help victims of military rape and PTSD with Denny Lyon Gifts @ Cafe Press to raise funds for charities helping vets
- Visual Insights - my photography, flickr friends' photography arranged into themed posts
- The Healing Waters - health posts, PTSD
- The Soul Calendar - witty writing on mostly astronomy, other sciences
- Comfort Food From Louisiana - featuring seafood, collection of great Louisiana food, some chef recipes too
- Romancing The Chocolate - great chocolate recipes, chef recipes, funny quotes about chocolate
- Dennys Food And Recipes - general food blog featuring chef recipes and other interesting ones I find while researching
- Unusual 2 Tasty - crazy but good recipes to expand your idea of food
- Dennys Art Sanctuary - some of my own work, collection of desktop themes by the month
- Dennys World Of Quotes - a growing place for all the quotes employed over the years
- Ouch Outrageous Obnoxious And Odd - less general audience humor
- Dennys People Watching - interesting people in the news
- Dennys Blog Feeds - before the web got easier, express links to all blogs and posts
- Dennys Guest Bloggers - links to all my blogs, when time if found: links to other good writes
Thursday, March 24, 2011
Post Roundup at Dennys Blogs - 24 March 2011
Posted by Denny Lyon at 8:43 PM
Labels: news, US, politics, funny arts, astronomy, cartoons, Charlie-Sheen, funny, humor, news, Oscars, people-news, photography, poetry, politics, posts-roundup, quotes, Recipes


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If you're into marketing and you go to the American Library Association's Annual Conference, then you probably know about the Swap & Shop event. It's a place where you can see what sorts of promotional materials are coming out of other libraries across the U.S. Any library can send in samples of its promo materials to be seen & picked up & taken home by other visitors. It's all about sharing ideas and successes.
There's also a promo-material contest that's part of the Swap & Shop. And if you want to enter this year's "Best of Show" contest, you need to send your entry by April 15.
Here are the details, from the Swap Committee:
We know your library has amazing promotional materials: Newsletters, program announcements, reading celebrations, websites, YouTube videos and more. Here's your chance to show them off! It's that time of year again—we are looking for entries for the LLAMA/PRMS Swap and Shop Best of Show competition!
How can you enter? Download the Best of Show entry form and FAQ (includes category options and submission guidelines) on the LLAMA web site at http://www.ala.org/ala/mgrps/divs/llama/awards/lamaprmsswap.cfm. Entries must be postmarked no later than April 15, 2010.
Promotional materials produced between January and December of 2009 are eligible for this year's contest. All categories will be judged on content, originality, design format and effectiveness by a team of experts in public relations and marketing.
For more information, contact Jennifer Duvernay at email@example.com, 480.727.7636
This year's Swap & Shop will be Sunday, June 27, 2010 from 11 a.m. to 1:30 p.m., during the ALA Annual Conference in Washington, D.C. The theme is "PR Xchange." The "Best of Show" winners, as well as the John Cotton Dana Library Public Relations Award winners, will be on display at the Swap.
You can read about last year's Swap & Shop here and here.


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After they dress the deer and tag it, they grab it by its hind legs and start dragging through the woods back to the car. A game warden happens on the pair and, after checking their tags and admiring the buck tells them that they are dragging the deer out all wrong. By dragging it by the rear legs, the snow, leaves and dirt are getting caught by the animals fur, and the horns are getting all tangled in the brush. The warden suggests that they drag it by the front legs. They agree to try it and much to their surprise, it is much easier dragging the deer this way.
After a half hour of this Sven turns to Ole and says, "Boy dat game warden was right, it sure is easier dragging de deer dis way, but ya know, we are getting further away from de car."


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Unfortunately, while I took many, many pictures of my yard once I moved into my house, being the incredibly well-organized person I am, I managed to lose almost all of them when I dropped my laptop and fried its hard drive. So these four pictures will have to make do.
This is one of two pictures that show the location of the pool that covered most of the back yard. When we removed it, the sand that it was constructed on was combined with compost to form the raised beds. And the "goldfish pond" along the east fence was also deconstructed and the blocks used to construct the raised beds. For the record, I'm not a huge fan of those landscape blocks, but hey, I was broke and they were free, and boy, were there a lot of them.
The east side yard:
To the left of the picture, you can see a bit of the "waterfall" perched on the corner of the goldfish pond. The water in that pond was an even scarier shade of green. But the neighborhood raccoons didn't seem to mind:
The west side yard. There's a raised bed where the old vegetable garden used to be:


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Wednesday, 1 April 2009
1 4 09
Can you spy my little helper?!
I have been thinking about what I can wear, because I obviously can't wear my usual vintage dresses. I am anticipating the weather to be nice seeing as it will be in August, but knowing British weather, this is probably just wishful thinking! So, I have been creating outfits on Polyvore. I know I am planning waaaay in advance, but that's just how I roll - super organized!
Blondie t-shirt - Forever21
Acid Wash Jeans - TopShop
Headband - Asos
Studded Bag - Asos
Leopard Print Wellies - Primark
Gingham Halterneck Top - Vivien of Holloway
Denim Shorts - Jane Norman
White Hair Flower - Flowerclip.com
Skull & Rose Wellies - Shop Mania
Playsuit - Fruition Las Vegas
Tote Bag - Shana Logic
Plimsolls - Asos
White Vest - TopShop
Red Skirt - American Apparel
Heart Print Wellies - Monsoon
Heart Sunglasses - Mod Cloth
14 comments:
- oniomania said...
i kind of like the 2nd and the 4th outfit because it has that vintage feel to it which is you.
but i love the first rock cheek outfit. plus you already have the wellies to go with it.
- 1 April 2009 at 21:05
- Twobreadsplease said...
The printed playsuit is so cute! And you have such a lovely boyfriend for buying you those wellies. Ahhh, I'm jealous that you're going to Reading, the line-up is looking pretty good. xx
- 1 April 2009 at 22:20
- Kathryn said...
Oh I hadn't noticed the halter tops from VofH! They'd look great with a 50's style skirt I have...
- 1 April 2009 at 22:50
- KB said...
These outfits look great! Be prepared for white pumps getting ruined though, I had to throw out a pair after my first Reading. Primark all the way!
- 1 April 2009 at 23:04
- janettaylor said...
Haha! I love Ur pair of rain boots! :) I have a miu miu rain boots, but I never use them. :S
- 2 April 2009 at 11:04
- Alyssa said...
I adore that second outift. Gingham is fantastic.
- 2 April 2009 at 12:51
- Staci said...
forever 21 makes me soo happy, i bought a vintage pink floyd t there the other day LOVE it!!
- 2 April 2009 at 20:07
- maçã said...
I really like the last one, but knowing festivals, I think the firts is the more indicated, because in the end, after all the energy, your legs will be very cold!
- 2 April 2009 at 20:36
- Helen said...
that last outfit is my favourite, i would love to wear that! infact i already have that skirt and heart shaped sunglasses hehe.
- 2 April 2009 at 22:45
- Wendy-May said...
i like the floral wellies! the 3 of us managed to get leeds fest tickets cannot wait! x
- 3 April 2009 at 09:36
- Pretty Little Pictures said...
Ooh, look at those boots! And look how cute your kitty is :)
- 6 April 2009 at 00:27
- Artificial Magazine said...
Your first outfit definitely rocks! Let's just hope the weather will be lovely...
- 6 April 2009 at 12:11
- Louisee x said...
just a warning haha, i wanted to wear a playsuit to V Festival last year, I went out and bought it especially, then it got to the morning of the festival, and I suddenly realised what a nightmare they are to go to the loo in! What with the state of festival loos already - doubly not a good idea!
I love all the outfits though :).
- 12 April 2009 at 17:39
- Wicked Halo said...
Love the second outfit, pretty cool, I'd just add the red heart shaped sunglasses from the last outfit for even extra neatness :)
- 24 April 2009 at 21:16


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Monday, April 17, 2006
Easter was ok. I was a little disappointed in a couple areas, but our guests were extremely happy. It was a beautiful day eventhough storms were predeicted. The ham was especialy nice. I roasted 5 whole hams on the bone which we carved in the kitchen and served with grilled peaches and peach beautiful sauce, 12 whole prime ribs, 100 pounds of mashed potatoes, 100 pounds of sweet potatoes, 80 pounds of asparagus. Vegetables and dip, cheese, and marinated olives were set at each table, along with our homemade breads-strawberry, white, and special for the hot cross buns. Service was family style, and desserts were strawberry shortcake and Easter egg nest fudge brownies. People loved the sweet potatoes-they are Mrs. Gallagher's favorite recipe. It was very much like an old farm house dinner which I think is perfect for holidays.
1 comment:
- Kevin said...
We're eating leftover pork this week also. I smoked 10lbs. of pork butt last weekend, now we have a huge bag of pulled pork. I smoked a brisket also, but I don't like doing them together due the cooking temp difference. I smoked a 10lb. brisket, along w/the butts for 9 hours at 220. Took it out and wrapped in foil, let it set for about 2 hours and it was moist and tasty. We had the neighbors over and there wasn't a morsel left. After I took the brisket out I kicked up the smoker to 275 for about 4 more hours. The bone just pulled out of the pork. I made some Coca Cola based sauce and slaw and haven't stopped smiling since. I think I'm going to do some more pork butt and chicken this weekend. I have a new smoker on order. Check it out BBQPits.com I'm getting the backyard chef. I'm adding a foot and extra shelves to it. I'm really anxious to try a whole hog..love your blog, keep adding to it!!!


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Archive for the 'ann peacock' Category
Genre: Historical Action/AdventurePremise: A forgotten king fights to take back his kingdom.About: These days it's hard to find bidding wars in Hollywood. Studios are getting cheap. But Friday was an exception as Warner Brothers battled it out with Paramount for the spec script, "Odysseus". I'm not sure how much it sold for but I assume […]
Filed under: ann peacock, Odysseus, recent spec sale, warner brothers | 12 Comments


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I can't get my head around it. It's alternately described by other readers as suspense or a thriller, but even that I can't quite figure out. Thriller? When I think of thrillers I think of chainsaw murderers. I don't like thrillers. I don't like blood and guts and extreme violence, so I don't write it.
The book is tense, yes. It faces topics of domestic abuse, stalking, etc, but there are only two violent scenes and even those are what I would consider extremely mild. I cataloged it as suspense for a reason.
I think my idea of "thriller" must be seriously out of whack.
What do you think? Is Without A Voice a thriller? Did you find it frightening?


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The public is invited to join executives from the World Series of Poker on Thursday May 19 for a Town Hall video conference hosted on the social media platform Twitch.
In attendance will be WSOP Executive Director Ty Stewart, WSOP Tournament Director Jack Effel and WSOP.com Head of Online Poker Bill Rini. The top brass will preview the 47th Annual World Series of Poker.
The group will be fielding questions from the media and the public. Those with questions are encouraged to submit them prior to the start time in the chat on Twitch. Questions submitted ahead of time via the WSOP Twitter account will also be considered.
The live stream will begin promptly at 4:00 PM EST / 1:00 PM PST.
The live Q&A session replaces the customary media conference call held in years past and further advances the WSOP initiative to move beyond a reliance on traditional poker media outlets and communicate directly with its fans and customers.
In 2015, the WSOP moved its primary media coverage in-house taking on the duties of being the "official live reporting team," for its events, a duty that had been outsourced to PokerNews and Bluff in previous years.
This year, series officials have brought in poker social media superstar Kevin Mathers (a.k.a Kevmath) to take over as the Series' "Twitter Czar." Instead of bringing in an outside company to handle its social media duties, Mathers who holds the title of Community Manager at PocketFives, is officially "on loan" to the WSOP.
In-house media is no stranger to the poker industry. PokerStars has a robust media operation including video production, photographers, podcasts and a blog which it uses to inform and entertain its customers.
The World Poker Tour also has very high production quality for its own media operations and other smaller tours such as the Heartland Poker Tour control the majority of their own media coverage as well.


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I have a request to make a portrait doll. Since I love this new pattern I've developed for the Halloween dolls, I thought I'd start with that and then improve upon it. I changed the hand slightly so that the needle sculpting looks better, and I changed the leg, and one of the arms. This little doll is a dancer! Foxy Blue asked me to make her a fairy and since I love the Cecily Mary Barker fairies, I'll be taking my inspiration from there. She never made a peony, which is Foxy's favorite flower, so, I'm on my own there for design. And Foxy's favorite color is aqua and I have some great fabrics that I'll be using for the skirt of her dress. I've drawn my conceptual design, and am wondering if I should leave her barefoot or make her some slippers.
|Left side
|Right side


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SS are given a long, thin strip of paper, and write a sentence (12 to 16 words?) describing how they feel at the moment.
Give out scissors so that they cut up the strips into individual words. SS shuffle the words and leave them in a pile on their chair. They change places and re-arrange someone else's sentence. Early finishers can change again or write the sentence in L1 to sensitise to word order.